title: Hepatic steatosis depresses alpha-1-antitrypsin levels in human and rat acute pancreatitis.
abstract: Hepatic steatosis (HS) can exacerbate acute pancreatitis (AP). This study aimed to investigate the relation between α1-antitrypsin (AAT) and acute pancreatitis when patients have HS. Using proteomic profiling, we identified 18 differently expressed proteins pots in the serum of rats with or without HS after surgical establishment of AP. AAT was found to be one of the significantly down-regulated proteins. AAT levels were significantly lower in hepatic steatosis acute pancreatitis (HSAP) than in non-HSAP (NHSAP) (P < 0.001). To explore the clinical significance of these observations, we measured the levels of AAT in the serum of 240 patients with HSAP, NHSAP, fatty liver disease (FLD), or no disease. Compared with healthy controls, serum AAT levels in patients with NHSAP were significantly higher (P < 0.01), while in patients with HSAP serum AAT levels were significantly lower (P < 0.01). Further studies showed that acute physiology and chronic health evaluation (APACHE-II) scores were negatively correlated with serum AAT levels (r = -0.85, P < 0.01). In conclusion, low serum levels of AAT in patients with HSAP are correlated with disease severity and AAT may represent a potential target for therapies aiming to improve pancreatitis.
authors.affiliation: Department of Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Yu
authors.affiliation: Department of Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Bai
authors.affiliation: Department of Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Zhanwei
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Shiqi
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Quanxin
authors.initials: Q
authors.lastname: Feng
authors.affiliation: Department of Surgery, China PLA 323323 Hospital, Beijing, 100853, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Qingchuan
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of General Surgery, Huashan Hospital North, Fudan University, Shanghai, 201907, China.|Department of Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, 710032, China.
authors.forename: Chaoxu
authors.initials: C
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D005234:Fatty Liver / Q000097:blood* / Q000150:complications / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood* / Q000150:complications / Q000473:pathology; D020543:Proteome / Q000235:genetics*; D051381:Rats; D014357:Trypsin / Q000097:blood; D000515:alpha 1-Antitrypsin / Q000097:blood* / Q000235:genetics
chemical_list: D020738:Leptin; D020543:Proteome; C043392:SERPINA1 protein, human; D000515:alpha 1-Antitrypsin; D014357:Trypsin