title: Recent advances in anticoagulant drug delivery.
abstract: BACKGROUND
  Anticoagulants have been prescribed to patients to prevent deep vein thrombosis or pulmonary embolism. However, because of several problems in anticoagulant therapy, much attention has been directed at developing an ideal anticoagulant, and numerous attempts have been made to develop new anticoagulant delivery systems in recent years.
  
  
  METHODS
  This review discusses the challenges associated with the recent development of anticoagulants and their delivery systems. Various delivery methods have been developed to improve the use of anticoagulants. Recent advances in anticoagulant delivery and antidote development are also discussed in the context of their current progression states.
  
  
  CONCLUSIONS
  There have been many different approaches to developing the delivery system of anticoagulants. One approach has been to expand the use of new oral agents and develop their antidotes. Reducing the size of heparins to use smaller heparins for delivery, and developing oral or topical heparins are also some of the approaches used. Various physical formulations or chemical modifications are other ways that have enhanced the therapeutic potential of anticoagulant agents. On the whole, recent advances have contributed to increasing the efficacy and safety of anticoagulant clinically and have benefited the field of anticoagulant delivery.
authors.affiliation: a Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul , Republic of Korea.
authors.forename: Jooho
authors.initials: J
authors.lastname: Park
authors.affiliation: a Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul , Republic of Korea.|b Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Pharmacy , Seoul National University , Seoul , Republic of Korea.
authors.forename: Youngro
authors.initials: Y
authors.lastname: Byun
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans
chemical_list: D000925:Anticoagulants; D006493:Heparin
keywords: Anticoagulant; NOACs; drug delivery; heparin; oral delivery; thrombosis