title: Claudin 1 in Breast Cancer: New Insights.
abstract: Claudin 1 is a small transmembrane protein responsible for maintaining the barrier function that exists between epithelial cells. A tight junction protein that regulates the paracellular transport of small ions across adjacent cells, claudin 1 maintains cellular polarity and plays a major role in cell-cell communication and epithelial cell homeostasis. Long considered to be a putative tumor suppressor in human breast cancer, new studies suggest a role much more complex. While most invasive breast cancers exhibit a down regulation or absence of claudin 1, some aggressive subtypes that exhibit high claudin 1 levels have now been described. Furthermore, a causal role for claudin 1 in breast cancer progression has recently been demonstrated in some breast cancer cell lines. In this review we highlight new insights into the role of claudin 1 in breast cancer, including its involvement in collective migration and epithelial mesenchymal transition (EMT).
authors.affiliation: Department of Pathology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E3P5, Canada. zhoub34@myumanitoba.ca.
authors.forename: Bowen
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Pathology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E3P5, Canada. moodie-a@webmail.uwinnipeg.ca.
authors.forename: Amanda
authors.initials: A
authors.lastname: Moodie
authors.affiliation: Department of Pathology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E3P5, Canada. anne.blanchard@umanitoba.ca.|Department of Physiology and Pathophysiology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E0J9, Canada. anne.blanchard@umanitoba.ca.
authors.forename: Anne A A
authors.initials: AA
authors.lastname: Blanchard
authors.affiliation: Department of Biochemistry and Human Genetics, University of Manitoba, Winnipeg, MB R3E0J9, Canada. Etienne.leygue@umanitoba.ca.
authors.forename: Etienne
authors.initials: E
authors.lastname: Leygue
authors.affiliation: Department of Pathology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E3P5, Canada. Yvonne.myal@umanitoba.ca.|Department of Physiology and Pathophysiology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E0J9, Canada. Yvonne.myal@umanitoba.ca.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Myal
keywords: EMT; breast cancer; claudin 1; collective migration; interacting partners; “high claudin”