title: Understanding Onychomycosis Treatment: Mechanisms of Action and Formulation.
abstract: Historically, the eradication of onychomycosis has been a frustrating and often unsuccessful endeavor. However, new understanding about the mechanisms of action of antifungal agents, the introduction of two new topical agents, and the drugs and devices now being investigated offer greatly improved options for current and future management of these infections. The mechanisms of action of systemic and topical antifungal agents and devices effective against the most common dermatophyte and nondermatophyte causes of onychomycosis are discussed. Semin Cutan Med Surg 34(supp3):S51-S53 © 2015 published by Frontline Medical Communications.
authors.affiliation: Assistant Clinical Professor, Department of Dermatology, Warren Alpert Medical School at Brown University, Adjunct Assistant Clinical Professor, Division of Dermatology, University of Massachusetts Medical School, Fellowship Director, Procedural Dermatology, Dermatology Professionals, Inc., East Greenwich, Rhode Island.
authors.forename: Nathaniel J
authors.initials: NJ
authors.lastname: Jellinek
keywords: Ciclopirox; efinaconazole; fluconazole; itraconazole; laser
  therapy; onychomycosis; photodynamic therapy; tavaborole; terbinafine