title: Magnetic resonance diffusion tensor imaging of cervical spinal cord and lumbosacral enlargement in patients with cervical spondylotic myelopathy.
abstract: To identify the correlations of diffusion tensor imaging (DTI) indices between the cervical spinal cord and lumbosacral enlargement in healthy volunteers and patients with cervical spondylotic myelopathy (CSM).
  
  
  
  DTI was performed at the cervical spinal cord and lumbosacral enlargement in 10 CSM patients and 10 volunteers at 1.5T. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values of were measured and compared between CSM patients and volunteers. DTI indices of different cervical segments in volunteers were compared. DTI indices of the cervical spinal cord were correlated with those of the lumbosacral enlargement.
  
  
  
  In healthy subjects, DTI indices of different cervical cord sections showed no significant difference (ADC: F = 0.62; P = 0.65; FA: F = 1.228; P = 0.312); there was no correlation between the DTI indices of the cervical spinal cord and those of the lumbosacral enlargement (ADC: r = 0.442, P = 0.201; FA: r = -0.054, P = 0.881). In the CSM patients, the ADC value significantly increased, while the FA value significantly decreased in the cervical spinal cord (ADC: P = 0.002; FA: P < 0.001) and lumbosacral enlargement (ADC: P = 0.003; FA: P < 0.001) compared with the healthy group. Both DTI indices showed no correlation between the cervical spinal cord and those of the lumbosacral enlargement in the CSM group (ADC: r = -0.052, P = 0.887; FA: r = 0.129, P = 0.722).
  
  
  
  The ADC value of the cervical spinal cord and lumbosacral enlargement in CSM patients showed significant increase compared with healthy volunteers, while the FA value significantly decreased. Both DTI indices of the cervical spinal cord had no linear correlation with those of the lumbosacral enlargement. J. Magn. Reson. Imaging 2016;43:1484-1491.
authors.affiliation: Department of Orthopedics, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
authors.forename: Xueming
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Orthopedics, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Kong
authors.affiliation: Department of Orthopedics, Tianjing Medical University General Hospital, Tianjing, China.
authors.forename: Shiqing
authors.initials: S
authors.lastname: Feng
authors.affiliation: Department of Orthopedics, China Rehabilitation Research Center, Beijing, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Guan
authors.affiliation: Department of Orthopedics, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
authors.forename: Zhenshan
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Department of Orthopedics, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
authors.forename: Libin
authors.initials: L
authors.lastname: Cui
authors.affiliation: Department of Orthopedics, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D066193:Cervical Cord / Q000473:pathology / Q000601:surgery; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008161:Lumbosacral Region / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013117:Spinal Cord Compression / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology*; D055009:Spondylosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*
keywords: cervical spinal cord; cervical spondylotic myelopathy; diffusion tensor imaging; lumbosacral enlargement; magnetic resonance imaging