title: Interneurons in the human olfactory system in Alzheimer's disease.
abstract: The principal olfactory structures display Alzheimer's disease (AD) related pathology at early stages of the disease. Consequently, olfactory deficits are among the earliest symptoms. Reliable olfactory tests for accurate clinical diagnosis are rarely made. In addition, neuropathological analysis postmortem of olfactory structures is often not made. Therefore, the relationship between the clinical features and the underlying pathology is poorly defined. Traditionally, research into Alzheimer's disease has focused on the degeneration of cortical temporal projection neurons and cholinergic neurons. Recent evidence has demonstrated the neurodegeneration of interneuron populations in AD. This review provides an updated overview of the pathological involvement of interneuron populations in the human olfactory system in Alzheimer's disease.
authors.affiliation: Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 13005 Ciudad Real, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Saiz-Sanchez
authors.affiliation: Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 13005 Ciudad Real, Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Flores-Cuadrado
authors.affiliation: Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 13005 Ciudad Real, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Ubeda-Bañon
authors.affiliation: Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 13005 Ciudad Real, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: de la Rosa-Prieto
authors.affiliation: Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 13005 Ciudad Real, Spain. Electronic address: Alino.Martinez@uclm.es.
authors.forename: Alino
authors.initials: A
authors.lastname: Martinez-Marcos
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D059329:Cholinergic Neurons / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007395:Interneurons / Q000378:metabolism / Q000473:pathology*; D009833:Olfactory Pathways / Q000378:metabolism / Q000473:pathology*; D018034:Olfactory Receptor Neurons / Q000378:metabolism / Q000473:pathology*; D012903:Smell / Q000502:physiology
keywords: Amyloid-β; Archicortex; Calcium binding protein; Somatostatin; Tau