title: Prevalence of sinusitis and efficacy of intranasal corticosteroid treatment on asthmatic symptoms in asthmatic patients with rhinosinusitis: a pilot study.
abstract: BACKGROUND
  Prevalence of sinusitis on sinus computed tomography (CT) in asthmatic patients and efficacy of intranasal corticosteroid treatment on asthmatic symptoms in asthmatic patients with rhinosinusitis on sinus CT is unclear.
  
  
  METHODS
  Sinus CT of asthmatic patients were evaluated using the Lund-Mackay system (LMS). Intranasal corticosteroid treatment (mometasone furoate) was newly added to symptomatic asthmatic patients with rhinosinusitis treated without intranasal corticosteroids, and the findings of the Asthma Control Test (ACT), Asthma Control Questionnaire in 5 items (ACQ5), spirometry, and sinus CT were evaluated before and 3 months after additional intranasal corticosteroid treatment.
  
  
  RESULTS
  In a total of 160 asthmatic patients, rhinosinusitis and maxillary, ethmoidal, sphenoidal, and frontal sinusitis were observed in 75.0%, 70.0%, 53.1%, 33.1%, and 28.8%, respectively. Nasal symptoms and rhinophonia were observed in 81.9% and 72.5%, respectively, and patients with nasal symptoms and those with rhinophonia both showed significantly higher LMS scores in each sinus. Chronic rhinosinusitis (CRS) was observed in 66.9%, and these patients had significantly more severe asthma than the patients without CRS. In patients with CRS, patients with rhinophonia showed significantly higher LMS scores than those without rhinophonia. ACT, ACQ5, and the value of the forced expiratory volume in 1 second (FEV1) all significantly improved 3 months after the additive intranasal corticosteroid treatment in 24 patients, despite the fact that their LMS scores remained unchanged.
  
  
  CONCLUSIONS
  Additive intranasal corticosteroid treatment may be an effective treatment option for symptomatic asthmatic patients with rhinosinusitis.
authors.affiliation: Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Fukuoka, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yatera
authors.affiliation: Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Fukuoka, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Yamasaki
authors.affiliation: Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Fukuoka, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Noguchi
authors.affiliation: Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Fukuoka, Japan.
authors.forename: Chinatsu
authors.initials: C
authors.lastname: Nishida
authors.affiliation: Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Fukuoka, Japan.
authors.forename: Keishi
authors.initials: K
authors.lastname: Oda
authors.affiliation: Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Fukuoka, Japan.
authors.forename: Kentarou
authors.initials: K
authors.lastname: Akata
authors.affiliation: Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Fukuoka, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kido
authors.affiliation: Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Fukuoka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishimoto
authors.affiliation: Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Fukuoka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
mesh_terms: D000281:Administration, Intranasal; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001249:Asthma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D015995:Prevalence; D012220:Rhinitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D013147:Spirometry; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones
keywords: asthma; computed tomography; intranasal corticosteroid; rhinosinusitis; sinus