title: Prognostic role of microRNA-210 in various carcinomas: a meta-analysis.
abstract: BACKGROUND
  MicroRNA (miRNA) expressive alterations are associated with cancer and have potential diagnostic and prognostic values in various malignancies. Here, we summarize the global predictive role of miR-210 expression for survival in patients with a variety of carcinomas.
  
  
  METHODS
  Eligible studies were identified through multiple search strategies. Data were assembled from studies investigating the relationship between miR-210 expression and survival in cancer patients. Hazard ratio (HR) was used as the common measure of association across studies: relative risk (RR) was considered equivalent to HR. Combined hazard ratios (HRs) of miR-210 for outcome were analyzed.
  
  
  RESULTS
  A total of 10 studies dealing with various carcinomas were included for this global meta-analysis. For overall survival (OS), the pooled hazard ratio (HR) of higher miR-210 expression in cancerous tissue was 2.41 (95% CI: 1.31-4.44), which could significantly predict poorer survival in general carcinomas. For distant-free, relapse-free or progressive-free survival, elevated miR-210 was also a significant predictor, with a pooled HR of 2.84 (95% CI: 2.10-3.83). Importantly, subgroup analysis suggested that higher expression of miR-210 correlated with worse OS in breast cancer: HR 4.34, 95% CI: 1.63-11.55.
  
  
  CONCLUSIONS
  Our findings reveal that miR-210 detection has a prognostic value in patients with cancer, especially in breast cancer.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Guangxi Medical University Nanning, China.
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Guangxi Medical University Nanning, China.
authors.forename: Wenhong
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Guangxi Medical University Nanning, China.
authors.forename: Ludong
authors.initials: L
authors.lastname: Liang
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Guangxi Medical University Nanning, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Han
authors.affiliation: Department of Management Information System, College of Computer and Information Engineering, Guangxi Teachers Education University Nanning, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Chen
authors.affiliation: Department of Pathophysiology, Guangxi Medical University Nanning, China.
authors.forename: Shangling
authors.initials: S
authors.lastname: Pan
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Guangxi Medical University Nanning, China.
authors.forename: Meijuan
authors.initials: M
authors.lastname: Xue
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Guangxi Medical University Nanning, China.
authors.forename: Shikang
authors.initials: S
authors.lastname: Li
keywords: cancer; meta-analysis; miR-210; prognosis