title: Flg22-Triggered Immunity Negatively Regulates Key BR Biosynthetic Genes.
abstract: In plants, activation of growth and activation of immunity are opposing processes that define a trade-off. In the past few years, the growth-promoting hormones brassinosteroids (BR) have emerged as negative regulators of pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI), promoting growth at the expense of defense. The crosstalk between BR and PTI signaling was described as negative and unidirectional, since activation of PTI does not affect several analyzed steps in the BR signaling pathway. In this work, we describe that activation of PTI by the bacterial PAMP flg22 results in the reduced expression of BR biosynthetic genes. This effect does not require BR perception or signaling, and occurs within 15 min of flg22 treatment. Since the described PTI-induced repression of gene expression may result in a reduction in BR biosynthesis, the crosstalk between PTI and BR could actually be negative and bidirectional, a possibility that should be taken into account when considering the interaction between these two pathways.
authors.affiliation: The Sainsbury Laboratory , Norwich, UK ; Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences , Shanghai, China.
authors.forename: Tamara
authors.initials: T
authors.lastname: Jiménez-Góngora
authors.affiliation: Department of Life Science, Chung-Ang University , Seoul, South Korea.
authors.forename: Seong-Ki
authors.initials: SK
authors.lastname: Kim
authors.affiliation: The Sainsbury Laboratory , Norwich, UK ; Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences , Shanghai, China.
authors.forename: Rosa
authors.initials: R
authors.lastname: Lozano-Durán
authors.affiliation: The Sainsbury Laboratory , Norwich, UK.
authors.forename: Cyril
authors.initials: C
authors.lastname: Zipfel
keywords: brassinosteroids; crosstalk; flagellin; immunity; transcriptional regulation