title: Psychosocial factors associated with adherence to non-insulin antidiabetes treatments.
abstract: OBJECTIVE
  To discern psychosocial factors of non-insulin antidiabetes drug (NIAD) adherence.
  
  
  METHODS
  A cross-sectional study based on the theory of planned behavior (TPB). Adults with type 2 diabetes (T2D) who were members of Diabète Québec, a provincial association of persons with diabetes, and were prescribed at least one NIAD were invited to complete a web-based questionnaire. We measured variables ascertaining TPB constructs and other factors potentially associated with NIAD adherence (e.g., habit, social support, and mental health). NIAD adherence was assessed using the 8-item Morisky Medication Adherence Scale. Factors were identified using a multivariate logistic regression model.
  
  
  RESULTS
  In our study, 901 participants (373 women; 515 retired; mean age: 62.7 years) with T2D for a mean of 10 years, completed the questionnaire. Participants exhibited a high intention to adhere to their NIAD treatment (mean score=5.8/6), positive attitudes toward adherence (mean score=5.5/6), and elevated perceived behavioral control in taking their medication (mean score=5.7/6). Only 405 (45%) participants reported high adherence (score=8/8). Perceived behavioral control, habit, older age, no perceived side effects, a longer period since T2D diagnosis and a lower number of NIAD daily doses were significantly associated with adherence (p<0.05).
  
  
  CONCLUSIONS
  We identified several factors that may be modified for NIAD adherence and thereby provided insight into future adherence-enhancing intervention targets.
authors.affiliation: Faculty of Pharmacy, Laval University, Quebec City, QC, Canada; Chair on Adherence to Treatments, Population Health and Optimal Health Practices Research Unit, CHU de Québec Research Center, Quebec City, QC, Canada. Electronic address: line.guenette@pha.ulaval.ca.
authors.forename: Line
authors.initials: L
authors.lastname: Guénette
authors.affiliation: Faculty of Pharmacy, Laval University, Quebec City, QC, Canada; Chair on Adherence to Treatments, Population Health and Optimal Health Practices Research Unit, CHU de Québec Research Center, Quebec City, QC, Canada.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Breton
authors.affiliation: Chair on Adherence to Treatments, Population Health and Optimal Health Practices Research Unit, CHU de Québec Research Center, Quebec City, QC, Canada; Faculty of Nursing, Laval University, Quebec City, QC, Canada.
authors.forename: Laurence
authors.initials: L
authors.lastname: Guillaumie
authors.affiliation: Faculty of Pharmacy, Laval University, Quebec City, QC, Canada; Chair on Adherence to Treatments, Population Health and Optimal Health Practices Research Unit, CHU de Québec Research Center, Quebec City, QC, Canada.
authors.forename: Sophie
authors.initials: S
authors.lastname: Lauzier
authors.affiliation: Faculty of Pharmacy, Laval University, Quebec City, QC, Canada; Chair on Adherence to Treatments, Population Health and Optimal Health Practices Research Unit, CHU de Québec Research Center, Quebec City, QC, Canada.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Grégoire
authors.affiliation: Faculty of Pharmacy, Laval University, Quebec City, QC, Canada; Chair on Adherence to Treatments, Population Health and Optimal Health Practices Research Unit, CHU de Québec Research Center, Quebec City, QC, Canada.
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Moisan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D008960:Models, Psychological; D011584:Psychology; D011792:Quebec / Q000453:epidemiology; D055815:Young Adult; D016903:Drug Monitoring
chemical_list: D007004:Hypoglycemic Agents
keywords: Association of patients; Medication adherence; Non-insulin antidiabetic; Psychosocial factors; Theory of planned behavior; Type 2 diabetes