title: Vasopressin regulates renal calcium excretion in humans.
abstract: Antidiuretic hormone or arginine vasopressin (AVP) increases water reabsorption in the collecting ducts of the kidney. Three decades ago, experimental models have shown that AVP may increase calcium reabsorption in rat kidney. The objective of this study was to assess whether AVP modulates renal calcium excretion in humans. We analyzed calcium, potassium, and sodium fractional excretion in eight patients affected by insipidus diabetes (nephrogenic or central) under acute vasopressin receptor agonist action and in 10 patients undergoing oral water load test affected or not by inappropriate antidiuretic hormone secretion (SIADH). Synthetic V2 receptor agonist (dDAVP) reduced significantly calcium fractional excretion from 1.71% to 0.58% (P < 0.05) in patients with central diabetes insipidus. In patients with nephrogenic diabetes insipidus (resistant to AVP), calcium fractional excretion did not change significantly after injection (0.48-0.68%, P = NS). In normal subjects undergoing oral water load test, calcium fractional excretion increased significantly from 1.02% to 2.54% (P < 0.05). Patients affected by SIADH had a high calcium fractional excretion at baseline that remained stable during test from 3.30% to 3.33% (P = NS), possibly resulting from a reduced calcium absorption in renal proximal tubule. In both groups, there was a significant correlation between urine output and calcium renal excretion. In humans, dDAVP decreases calcium fractional excretion in the short term. Conversely, water intake, which lowers AVP concentration, increases calcium fractional excretion. The correlation between urine output and calcium excretion suggests that AVP-related antidiuresis increases calcium reabsorption in collecting ducts.
authors.affiliation: UMR S 1155, Sorbonne Universités UPMC Univ Paris 06, Paris, France UMR S 1155, INSERM, Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Hanouna
authors.affiliation: UMR S 1155, Sorbonne Universités UPMC Univ Paris 06, Paris, France UMR S 1155, INSERM, Paris, France Explorations Fonctionnelles Multidisciplinaires, AP-HP, Paris, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Haymann
authors.affiliation: UMR S 1155, Sorbonne Universités UPMC Univ Paris 06, Paris, France UMR S 1155, INSERM, Paris, France Explorations Fonctionnelles Multidisciplinaires, AP-HP, Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Baud
authors.affiliation: UMR S 1155, Sorbonne Universités UPMC Univ Paris 06, Paris, France UMR S 1155, INSERM, Paris, France Explorations Fonctionnelles Multidisciplinaires, AP-HP, Paris, France emmanuel.letavernier@tnn.aphp.fr.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Letavernier
keywords: SIADH; Vasopressin; calcium; kidney