title: Expression of RKIP, E-cadherin and NF-kB p65 in esophageal squamous cell carcinoma and their correlations.
abstract: To detect the expression of RKIP, E-cadherin and NF-kB p65 in esophageal squamous cell carcinoma (ESCC) and study their correlations. Steptavidin-peroxidase (S-P) method was employed to detect the expressions of RKIP, E-cadherin and NF-kB p65 in ESCC tissues from 77 cases and paracancerous tissues from 77 cases. The correlations between their expressions and clinicopathological indices and between the expressions of these proteins themselves were analyzed. The expressions of RKIP and E-cadherin in ESCC tissues were obviously lower than those in the paracancerous tissues (P<0.01); the expressions in ESCC tissues from cases with lymph node metastasis were lower than those from cases without lymph node metastasis (P<0.01); the expression of RKIP was positively correlated with the expression of E-cadherin in ESCC tissues (P<0.01). The expression of NF-kB p65 in ESCC tissues was correlated with clinical staging, lymph node metastasis and tumor differentiation (P<0.01); the expression of RKIP was negatively correlated with the expression of NF-kB p65 in ESCC tissues (P<0.05). Downregulation or depletion of RKIP was related to the onset and progression of ESCC, and facilitated the invasion and metastasis of ESCC by downregulating E-cadherin and upregulating NF-kB p65.
authors.affiliation: The Affiliated Hospital of Hebei University of Engineering Handan 056002, Hebei Province, China.
authors.forename: Fu-Min
authors.initials: FM
authors.lastname: Ping
authors.affiliation: The Affiliated Hospital of Hebei University of Engineering Handan 056002, Hebei Province, China.
authors.forename: Gui-Jing
authors.initials: GJ
authors.lastname: Liu
authors.affiliation: The Affiliated Hospital of Hebei University of Engineering Handan 056002, Hebei Province, China.
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Liu
authors.affiliation: The Affiliated Hospital of Hebei University of Engineering Handan 056002, Hebei Province, China.
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Li
authors.affiliation: The Affiliated Hospital of Hebei University of Engineering Handan 056002, Hebei Province, China.
authors.forename: Jian-Wen
authors.initials: JW
authors.lastname: Zhai
authors.affiliation: The Affiliated Hospital of Hebei University of Engineering Handan 056002, Hebei Province, China.
authors.forename: Shu-Xia
authors.initials: SX
authors.lastname: Li
authors.affiliation: The Affiliated Hospital of Hebei University of Engineering Handan 056002, Hebei Province, China.
authors.forename: Yue-Mei
authors.initials: YM
authors.lastname: Liu
authors.affiliation: The Affiliated Hospital of Hebei University of Engineering Handan 056002, Hebei Province, China.
authors.forename: Bao-Wei
authors.initials: BW
authors.lastname: Li
authors.affiliation: The Affiliated Hospital of Hebei University of Engineering Handan 056002, Hebei Province, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wei
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D015536:Down-Regulation; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D049488:Phosphatidylethanolamine Binding Protein / Q000378:metabolism*; D051996:Transcription Factor RelA / Q000378:metabolism*
chemical_list: D015820:Cadherins; C511482:PEBP1 protein, human; D049488:Phosphatidylethanolamine Binding Protein; D051996:Transcription Factor RelA
keywords: E-cadherin; Esophageal squamous cell carcinoma (ESCC); NF-kB p65; RKIP