title: StreptomeDB 2.0--an extended resource of natural products produced by streptomycetes.
abstract: Over the last decades, the genus Streptomyces has stirred huge interest in the scientific community as a source of bioactive compounds. The majority of all known antibiotics is isolated from these bacterial strains, as well as a variety of other drugs such as antitumor agents, immunosuppressants and antifungals. To the best of our knowledge, StreptomeDB was the first database focusing on compounds produced by streptomycetes. The new version presented herein represents a major step forward: its content has been increased to over 4000 compounds and more than 2500 host organisms. In addition, we have extended the background information and included hundreds of new manually curated references to literature. The latest update features a unique scaffold-based navigation system, which enables the exploration of the chemical diversity of StreptomeDB on a structural basis. We have included a phylogenetic tree, based on 16S rRNA sequences, which comprises more than two-thirds of the included host organisms. It enables visualizing the frequency, appearance, and persistence of compounds and scaffolds in an evolutionary context. Additionally, we have included predicted MS- and NMR-spectra of thousands of compounds for assignment of experimental data. The database is freely accessible via http://www.pharmaceutical-bioinformatics.org/streptomedb.
authors.affiliation: Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences, Albert-Ludwigs-University, Hermann-Herder-Strasse 9, Freiburg 79104, Germany.
authors.forename: Dennis
authors.initials: D
authors.lastname: Klementz
authors.affiliation: Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences, Albert-Ludwigs-University, Hermann-Herder-Strasse 9, Freiburg 79104, Germany.
authors.forename: Kersten
authors.initials: K
authors.lastname: Döring
authors.affiliation: Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences, Albert-Ludwigs-University, Hermann-Herder-Strasse 9, Freiburg 79104, Germany School of Life Sciences, Division of Biological Chemistry and Drug Discovery, University of Dundee, James Black Centre, Dow Street, Dundee DD1 5EH, UK.
authors.forename: Xavier
authors.initials: X
authors.lastname: Lucas
authors.affiliation: Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences, Albert-Ludwigs-University, Hermann-Herder-Strasse 9, Freiburg 79104, Germany.
authors.forename: Kiran K
authors.initials: KK
authors.lastname: Telukunta
authors.affiliation: Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences, Albert-Ludwigs-University, Hermann-Herder-Strasse 9, Freiburg 79104, Germany Chair for Bioinformatics, Department of Computer Science, University of Freiburg, Georges-Koehler-Allee 106, Freiburg 79110, Germany.
authors.forename: Anika
authors.initials: A
authors.lastname: Erxleben
authors.affiliation: Pharmaceutical Biology, Institute of Pharmaceutical Sciences, Albert-Ludwigs-University, 79104 Freiburg, Germany.
authors.forename: Denise
authors.initials: D
authors.lastname: Deubel
authors.affiliation: Pharmaceutical Biology, Institute of Pharmaceutical Sciences, Albert-Ludwigs-University, 79104 Freiburg, Germany.
authors.forename: Astrid
authors.initials: A
authors.lastname: Erber
authors.affiliation: Pharmaceutical Biology, Institute of Pharmaceutical Sciences, Albert-Ludwigs-University, 79104 Freiburg, Germany.
authors.forename: Irene
authors.initials: I
authors.lastname: Santillana
authors.affiliation: Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences, Albert-Ludwigs-University, Hermann-Herder-Strasse 9, Freiburg 79104, Germany.
authors.forename: Oliver S
authors.initials: OS
authors.lastname: Thomas
authors.affiliation: Pharmaceutical Biology, Institute of Pharmaceutical Sciences, Albert-Ludwigs-University, 79104 Freiburg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Bechthold
authors.affiliation: Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences, Albert-Ludwigs-University, Hermann-Herder-Strasse 9, Freiburg 79104, Germany stefan.guenther@pharmazie.uni-freiburg.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Günther
mesh_terms: D001688:Biological Products / Q000737:chemistry* / Q000378:metabolism; D062126:Databases, Chemical; D010802:Phylogeny; D013302:Streptomyces / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000378:metabolism
chemical_list: D001688:Biological Products