title: Effective treatment of cytomegalovirus retinitis and neuritis with retrobulbar ganciclovir after treosulfan-based autologous bone marrow transplant.
abstract: We describe the case of a 16-month-old girl with neuroblastoma and chronic lymphocytopenia due to chemotherapy and treosulfan-containing megatherapy who developed cytomegalovirus retinitis and neuritis. Intravenous ganciclovir and anti-cytomegalovirus immunoglobulin were used with a transient benefit; however, retrobulbar gancyclovir resulted in a complete remission. This report emphasizes the need for close monitoring of viral infections in patients undergoing treosulfan-containing megatherapy, highlighting the immunosuppressive effects of this agent, and indicates the potential use of retrobulbar ganciclovir as the alternative method of drug delivery.
authors.forename: Anna
authors.initials: A
authors.lastname: Raciborska
authors.forename: Marek
authors.initials: M
authors.lastname: Ussowicz
authors.forename: Marek
authors.initials: M
authors.lastname: Prost
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Bilska
authors.forename: Carlos
authors.initials: C
authors.lastname: Rodriguez-Galindo
authors.forename: Magdalena
authors.initials: M
authors.lastname: Rychlowska-Pruszynska
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects; D000998:Antiviral Agents / Q000008:administration & dosage*; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002066:Busulfan / Q000009:adverse effects / Q000031:analogs & derivatives; D003586:Cytomegalovirus Infections / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D015774:Ganciclovir / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000150:complications / Q000628:therapy; D012173:Retinitis / Q000188:drug therapy* / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D000998:Antiviral Agents; C018404:treosulfan; D002066:Busulfan; D015774:Ganciclovir