title: Ehrlichia's molecular tricks to manipulate their host cells.
abstract: Ehrlichia is a large genus of obligate intracellular Gram-negative bacteria transmitted by ticks that cause several emerging infectious diseases in humans and are pathogenic on rodents, ruminants, and dogs. Ehrlichia spp. invade and replicate either in endothelial cells, white blood cells, or within midgut cells and salivary glands of their vector ticks. In this review, we discuss the insights that functional studies are providing on how this group of bacteria exploits their host by subverting host innate immunity and hijacking cellular processes.
authors.affiliation: CIRAD, UMR CMAEE, Site de Duclos, Prise d'eau, F-97170 Petit-Bourg, Guadeloupe, France; INRA, UMR1309 CMAEE, F-34398 Montpellier, France; Université des Antilles et de la Guyane, 97159 Pointe-à-Pitre Cedex, Guadeloupe, France.
authors.forename: Amal
authors.initials: A
authors.lastname: Moumène
authors.affiliation: CIRAD, UMR CMAEE, Site de Duclos, Prise d'eau, F-97170 Petit-Bourg, Guadeloupe, France; INRA, UMR1309 CMAEE, F-34398 Montpellier, France. Electronic address: damien.meyer@cirad.fr.
authors.forename: Damien F
authors.initials: DF
authors.lastname: Meyer
mesh_terms: D000818:Animals; D004285:Dogs; D004536:Ehrlichia / Q000472:pathogenicity*; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D012377:Rodentia; D013987:Ticks
keywords: Bacterial-host interaction; Effectors; Ehrlichia; T4SS