title: The Cytochrome bd Oxidase of Porphyromonas gingivalis Contributes to Oxidative Stress Resistance and Dioxygen Tolerance.
abstract: Porphyromonas gingivalis is an etiologic agent of periodontal disease in humans. The disease is associated with the formation of a mixed oral biofilm which is exposed to oxygen and environmental stress, such as oxidative stress. To investigate possible roles for cytochrome bd oxidase in the growth and persistence of this anaerobic bacterium inside the oral biofilm, mutant strains deficient in cytochrome bd oxidase activity were characterized. This study demonstrated that the cytochrome bd oxidase of Porphyromonas gingivalis, encoded by cydAB, was able to catalyse O2 consumption and was involved in peroxide and superoxide resistance, and dioxygen tolerance.
authors.affiliation: EA1254 Microbiologie-Risques Infectieux, University of Rennes1, Rennes, France.
authors.forename: Julia
authors.initials: J
authors.lastname: Leclerc
authors.affiliation: UMR CNRS 7266 LIENSs, University of La Rochelle, La Rochelle, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Rosenfeld
authors.affiliation: EA1254 Microbiologie-Risques Infectieux, University of Rennes1, Rennes, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Trainini
authors.affiliation: EA1254 Microbiologie-Risques Infectieux, University of Rennes1, Rennes, France.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Martin
authors.affiliation: EA1254 Microbiologie-Risques Infectieux, University of Rennes1, CHU Rennes,  Rennes, France.|UMR CNRS 7266 LIENSs, University of La Rochelle, La Rochelle, France.|CHU Rennes, Rennes, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Meuric
authors.affiliation: EA1254 Microbiologie-Risques Infectieux, University of Rennes1, CHU Rennes, Rennes, France.|UMR CNRS 7266 LIENSs, University of La Rochelle, La Rochelle, France.|CHU Rennes, Rennes, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Bonnaure-Mallet
authors.affiliation: EA1254 Microbiologie-Risques Infectieux, University of Rennes1, Rennes, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Baysse
mesh_terms: D001422:Bacterial Adhesion; D002460:Cell Line; D003576:Electron Transport Complex IV / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism*; D010545:Peroxides / Q000378:metabolism; D016966:Porphyromonas gingivalis / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D010545:Peroxides; D012333:RNA, Messenger; D013481:Superoxides; D003576:Electron Transport Complex IV; D010100:Oxygen