title: Modulation of Immune Response Using Engineered Nanoparticle Surfaces.
abstract: Nanoparticles (NPs) coated with a monolayer of ligands can be recognized by different components of the immune system, opening new doors for the modulation of immunological responses. By the use of different physical or chemical properties at the NP surface (such as charge, functional groups, and ligand density), NPs can be designed to have distinct cellular uptake, cytokine secretion, and immunogenicity, factors that influence the distribution and clearance of these particles. Understanding these immunological responses is critical for the development of new NP-based carriers for the delivery of therapeutic molecules, and as such several studies have been performed to understand the relationships between immune responses and NP surface functionality. In this review, we will discuss recent reports of these structure-activity relationships, and explore how these motifs can be controlled to elicit therapeutically useful immune responses.
authors.affiliation: Department of Chemistry University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA, 01003, USA.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Moyano
authors.affiliation: Department of Chemistry University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA, 01003, USA.
authors.forename: Yuanchang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Laboratory of Nanomedicine, Department of Cell Research and Immunology, Department of Materials Science and Engineering, Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, 69978, Israel.
authors.forename: Dan
authors.initials: D
authors.lastname: Peer
authors.affiliation: Department of Chemistry University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA, 01003, USA.
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D057927:Hydrophobic and Hydrophilic Interactions; D007109:Immunity; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D013499:Surface Properties
keywords: functional surfaces; immune response; nanoparticles; protein coronas