title: Impact of adiposity on cellular adhesion: The Multi-Ethnic Study of atherosclerosis (MESA).
abstract: OBJECTIVE
  At the cellular level, how excess adiposity promotes atherogenesis is not fully understood. One pathway involves secretion of adipokines that stimulate endothelial dysfunction through increased expression of adhesion molecules. However, the relationship of adiposity to adhesion molecules that promote atherosclerosis is largely unknown.
  
  
  METHODS
  Linear regression models were used to assess the sex-specific associations of soluble cellular adhesion molecules (sP- and sL-selectin, sICAM-1, sVCAM-1, and sHGF) and adiposity in 5,974 adults examined as part of the Multi-Ethnic Study of Atherosclerosis (MESA). Adiposity measures included body mass index (BMI), waist-to-hip-ratio (WHR), and computed tomography measures of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT).
  
  
  RESULTS
  The mean age was 64 years and 52% were female. In multivariable models adjusting for traditional cardiovascular risk factors, sHGF was positively associated with BMI, WHR, and VAT in both males and females, and sP-selectin with WHR and VAT in males. sVCAM-1 was inversely associated with VAT in females only.
  
  
  CONCLUSIONS
  Our results showed the relation of adiposity to soluble cellular adhesion proteins was similar across adiposity measures and for both sexes. However, the relationship between adiposity and sVCAM-1 and P-selectin may be modified by sex and the measure used to assess adiposity.
authors.affiliation: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Christoph
authors.affiliation: Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California, USA.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Allison
authors.affiliation: Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: James S
authors.initials: JS
authors.lastname: Pankow
authors.affiliation: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Decker
authors.affiliation: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Phillip S
authors.initials: PS
authors.lastname: Kirsch
authors.affiliation: Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Tsai
authors.affiliation: Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
authors.forename: Michele M
authors.initials: MM
authors.lastname: Sale
authors.affiliation: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Mariza
authors.initials: M
authors.lastname: de Andrade
authors.affiliation: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Hugues
authors.initials: H
authors.lastname: Sicotte
authors.affiliation: Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Weihong
authors.initials: W
authors.lastname: Tang
authors.affiliation: Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Naomi Q
authors.initials: NQ
authors.lastname: Hanson
authors.affiliation: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.|Montefiore Medical Center, Bronx, New York, USA.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Berardi
authors.affiliation: Department of Epidemiology, University of Pittsburgh, Pennsylvania, USA.
authors.forename: Christina L
authors.initials: CL
authors.lastname: Wassel
authors.affiliation: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Nicholas B
authors.initials: NB
authors.lastname: Larson
authors.affiliation: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Suzette J
authors.initials: SJ
authors.lastname: Bielinski
mesh_terms: D050154:Adiposity; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000503:physiopathology*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000208:ethnology* / Q000503:physiopathology*; D015815:Cell Adhesion Molecules / Q000502:physiology*; D003431:Cross-Cultural Comparison; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000208:ethnology* / Q000503:physiopathology*; D012307:Risk Factors; D050151:Subcutaneous Fat / Q000503:physiopathology; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D015815:Cell Adhesion Molecules