title: Synthetic approaches towards alkaloids bearing α-tertiary amines.
abstract: Alkaloids account for some of the most beautiful and biologically active natural products. Although they are usually classified along biosynthetic criteria, they can also be categorized according to certain structural motifs. Amongst these, the α-tertiary amine (ATA), i.e. a tetrasubstituted carbon atom surrounded by three carbons and one nitrogen, is particularly interesting. A limited number of methods have been described to access this functional group and fewer still are commonly used in synthesis. Herein, we review some approaches to asymmetrically access ATAs and provide an overview of alkaloid total syntheses where those have been employed.
authors.affiliation: Fakultät für Chemie und Pharmazie, Ludwig-Maximilians-Universität München, and Munich Center for Integrated Protein Science, Butenandtstr. 5 - 13, 81377 München, Germany. Dirk.Trauner@lmu.de.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Hager
authors.forename: Nina
authors.initials: N
authors.lastname: Vrielink
authors.forename: Dominik
authors.initials: D
authors.lastname: Hager
authors.forename: Julien
authors.initials: J
authors.lastname: Lefranc
authors.forename: Dirk
authors.initials: D
authors.lastname: Trauner
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D000588:Amines