title: Cell Competition During Growth and Regeneration.
abstract: Tissue growth and regeneration are autonomous, stem-cell-mediated processes in which stem cells within the organ self-renew and differentiate to create new cells, leading to new tissue. The processes of growth and regeneration require communication and interplay between neighboring cells. In particular, cell competition, which is a process in which viable cells are actively eliminated by more competitive cells, has been increasingly implicated to play an important role. Here, we discuss the existing literature regarding the current landscape of cell competition, including classical pathways and models, fitness fingerprint mechanisms, and immune system mechanisms of cell competition. We further discuss the clinical relevance of cell competition in the physiological processes of tissue growth and regeneration, highlighting studies in clinically important disease models, including oncological, neurological, and cardiovascular diseases.
authors.affiliation: Institut für Zellbiologie, University of Bern, CH-3012 Bern, Switzerland; email: emoreno@izb.unibe.ch.|Department of Radiology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire 03766.
authors.forename: Rajan
authors.initials: R
authors.lastname: Gogna
authors.affiliation: Department of Radiology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire 03766.
authors.forename: Kevin
authors.initials: K
authors.lastname: Shee
authors.affiliation: Institut für Zellbiologie, University of Bern, CH-3012 Bern, Switzerland; email: emoreno@izb.unibe.ch.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Moreno
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000378:metabolism; D002450:Cell Communication; D002468:Cell Physiological Phenomena / Q000502:physiology*; D004330:Drosophila / Q000166:cytology; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D016259:Genes, myc; D006321:Heart / Q000196:embryology; D006801:Humans; D008322:Mammals; D009154:Mutation; D009203:Myocardial Infarction / Q000473:pathology*; D009206:Myocardium / Q000166:cytology; D009369:Neoplasms / Q000473:pathology; D012038:Regeneration / Q000502:physiology*
chemical_list: C000597193:Azot protein, Drosophila; D015220:Calcium Channels; D002135:Calcium-Binding Proteins; D029721:Drosophila Proteins; C577694:Flower protein, mouse; C543900:fwe protein, Drosophila
keywords: azot; cancer; cell competition; fitness fingerprints; flower; regeneration