title: Long-term Impact of Childhood Adiposity on Adult Metabolic Syndrome Is Modified by Insulin Resistance: The Bogalusa Heart Study.
abstract: Childhood adiposity and insulin resistance are well-known risk factors for adult metabolic syndrome (MetS). This study aims to examine whether the association between childhood adiposity and adult MetS is modified by insulin resistance. The cohort consisted of 1,593 black and white subjects, aged 19-50 years at follow-up, who were examined 19 years apart on average as children and adults for MetS variables. The prevalence of adult MetS was compared between the insulin-sensitive obesity and insulin-resistant obesity groups in childhood. Adult MetS prevalence was higher in the insulin-resistant obesity group than in the insulin-sensitive obesity group (34.9% vs. 24.3%, p = 0.008). In multivariable logistic regression analyses adjusted for age, race, gender, and follow-up years, individuals with insulin-resistant obesity in childhood were 1.7 times (p = 0.011) more likely to have MetS 19 years later on average than those with insulin-sensitive obesity in childhood. Odds ratio did not differ significantly between blacks and whites (p = 0.724). ORs for the association of childhood BMI with adult MetS significantly increased with increasing tertiles of childhood HOMA (p < 0.001 for trend). These findings suggest that insulin resistance amplifies the association between childhood adiposity and adult MetS and underscore the importance of preventing both adiposity and insulin resistance in early life.
authors.affiliation: Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China.|Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, LA.
authors.forename: Huijie
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, LA.|Department of Biostatistics, School of Public Health, Shandong University, Jinan, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, LA.
authors.forename: Shengxu
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, LA.
authors.forename: Azad
authors.initials: A
authors.lastname: Hussain
authors.affiliation: Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, LA.
authors.forename: Camilo
authors.initials: C
authors.lastname: Fernandez
authors.affiliation: Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, LA.
authors.forename: Emily
authors.initials: E
authors.lastname: Harville
authors.affiliation: Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, LA.
authors.forename: Lydia A
authors.initials: LA
authors.lastname: Bazzano
authors.affiliation: Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, LA.
authors.forename: Jiang
authors.initials: J
authors.lastname: He
authors.affiliation: Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, LA.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D050154:Adiposity; D000328:Adult; D044383:Black People; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D016015:Logistic Models; D008145:Louisiana; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology*; D016017:Odds Ratio; D044465:White People; D001741:Black or African American
chemical_list: D001786:Blood Glucose; D007328:Insulin