title: Monocyte chemoattractant protein-1 and the kidney.
abstract: OBJECTIVE
  Recently, initial studies have been carried out in patients using monocyte chemoattractant protein-1 (MCP-1) inhibitors. This review summarizes the known function of MCP-1 in regulating monocytes during inflammation and its role in inflammatory disease of the kidney.
  
  
  RESULTS
  MCP-1 is one of the first chemokines described and plays an important role in renal inflammatory disease. The function of MCP-1 has been investigated and analyzed in both animal models of renal disease and renal patients. MCP-1 mediates firstly the release of monocytes from the bone marrow, and then generates a gradient in the endothelial glycocalyx to direct monocytes to sites of inflammation, thereby alleviating the migration of blood leukocytes into the inflamed tissue. In addition, MCP-1 has direct signaling effects in monocytes and influences migration, proliferation, and differentiation of leukocytes. Blockade of MCP-1 in several models of renal disease has ameliorated the disease, suggesting that inhibition of MCP-1 is a promising and valid strategy to treat patients with renal inflammatory disease.
  
  
  CONCLUSIONS
  Understanding the role of MCP-1 in monocyte homeostasis and the implications of MCP-1 inhibition in renal disease will help in designing better diagnostic and therapeutic strategies in patients with inflammatory renal disease.
authors.affiliation: Department of Nephrology and Hypertension, Medizinische Hochschule Hannover, Hannover, Germany.
authors.forename: Hermann
authors.initials: H
authors.lastname: Haller
authors.forename: Anna
authors.initials: A
authors.lastname: Bertram
authors.forename: Felix
authors.initials: F
authors.lastname: Nadrowitz
authors.forename: Jan
authors.initials: J
authors.lastname: Menne
mesh_terms: D000818:Animals; D002465:Cell Movement; D018932:Chemokine CCL2 / Q000037:antagonists & inhibitors / Q000502:physiology*; D003928:Diabetic Nephropathies / Q000209:etiology; D006801:Humans; D007668:Kidney / Q000502:physiology; D007674:Kidney Diseases / Q000209:etiology*; D009000:Monocytes / Q000502:physiology; D009393:Nephritis / Q000209:etiology; D014657:Vasculitis / Q000209:etiology
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2