title: Lowering urinary oxalate excretion to decrease calcium oxalate stone disease.
abstract: Dietary modifications should be considered as a first line approach in the treatment of idiopathic calcium oxalate nephrolithiasis. The amounts of oxalate and calcium consumed in the diet are significant factors in the development of the disease due to their impact on urinary oxalate excretion. There are a number of strategies that can be employed to reduce oxalate excretion. The consumption of oxalate-rich foods should be avoided and calcium intake adjusted to 1000-1200 mg/day. To encourage compliance it should be emphasized to patients that they be vigilant with this diet as a deviation in any meal or snack could potentially result in significant stone growth. The evidence underlying these two modifications is outlined and other strategies to reduce urinary oxalate excretion are reviewed.
authors.affiliation: Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USA. rholmes@uab.edu.
authors.forename: Ross P
authors.initials: RP
authors.lastname: Holmes
authors.affiliation: Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: John
authors.initials: J
authors.lastname: Knight
authors.affiliation: Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Dean G
authors.initials: DG
authors.lastname: Assimos
mesh_terms: D002129:Calcium Oxalate / Q000378:metabolism*; D002136:Calcium, Dietary / Q000008:administration & dosage; D006801:Humans; D007408:Intestinal Absorption; D007669:Kidney Calculi / Q000517:prevention & control*; D010070:Oxalates / Q000008:administration & dosage / Q000652:urine*; D020624:Oxalobacter formigenes / Q000502:physiology
chemical_list: D002136:Calcium, Dietary; D010070:Oxalates; D002129:Calcium Oxalate