title: Clinical significance of IL-2 and IL-10 gene polymorphisms and serum levels in patients with basal-cell carcinoma.
abstract: METHODS
  Polymorphic variants of IL-2 gene (-330 T/G and +166 G/T), IL-10 gene (-1082 G/A and -819 C/T) and serum cytokines concentrations in the group of 179 patients with BCC and 173 controls were analyzed.
  
  
  RESULTS
  The presence of the IL-2 -330 GG genotype or IL-10 -1082 GA increased the risk of BCC (OR 3.68) (OR 3.07). IL-10 -1082 AA or GA and IL-2 -330 GG genotype increased the risk of BCC (OR 9.63). IL-2 serum levels were significantly lower (p < 0.0004) in BCC patients while IL-10 concentration was significantly higher (p < 0.00001).
  
  
  CONCLUSIONS
  The polymorphisms in IL-2 and IL-10 genes may contribute to BCC susceptibility and influence the clinical course of BCC in polish population.
authors.affiliation: Department of Dermatology, Venereology & Allergology, Medical University of Gdansk, 7 Debinki Street, 80-952 Gdansk, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Sobjanek
authors.affiliation: Department of Dermatology, Venereology & Allergology, Medical University of Gdansk, 7 Debinki Street, 80-952 Gdansk, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Zabłotna
authors.affiliation: Department of Pediatrics, Hematology & Oncology, Medical University of Gdansk, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Bień
authors.affiliation: Department of Dermatology, Venereology & Allergology, Medical University of Gdansk, 7 Debinki Street, 80-952 Gdansk, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Gleń
authors.affiliation: Department of Dermatology, Venereology & Allergology, Medical University of Gdansk, 7 Debinki Street, 80-952 Gdansk, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Sokołowska-Wojdyło
authors.affiliation: Department of Pathology & Experimental Rheumatology, Medical University of Gdansk, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Ruckemann-Dziurdzińska
authors.affiliation: Department of Dermatology, Venereology & Allergology, Medical University of Gdansk, 7 Debinki Street, 80-952 Gdansk, Poland.
authors.forename: Roman
authors.initials: R
authors.lastname: Nowicki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000097:blood* / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000097:blood* / Q000235:genetics*; D007376:Interleukin-2 / Q000097:blood* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012878:Skin Neoplasms / Q000097:blood* / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C508609:IL10 protein, human; C508594:IL2 protein, human; D007376:Interleukin-2; D016753:Interleukin-10
keywords: BC; IL-10; IL-2; basal-cell carcinoma; gene polymorphism; interleukin serum concentrations