title: A bivalent role of TIP60 histone acetyl transferase in human cancer.
abstract: Acetylation is a major modification that is required for gene regulation, genome maintenance and metabolism. A dysfunctional acetylation plays an important role in several diseases, including cancer. A group of enzymes-lysine acetyltransferases are responsible for this modification and act in regulation of transcription as cofactors and by acetylation of histones and other proteins. Tip60, a member of MYST family, is expressed ubiquitously and is the acetyltransferase catalytic subunit of human NuA4 complex. This HAT has a well-characterized involvement in many processes, such as cellular signaling, DNA damage repair, transcriptional and cellular cycle. Aberrant lysine acetyltransferase functions promote or suppress tumorigenesis in different cancers such as colon, breast and prostate tumors. Therefore, Tip60 might be a potential and important therapeutic target in the cancer treatment; new histone acetyl transferase inhibitors were identified and are more selective inhibitors of Tip60.
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 place Henri Dunant, 63001 Clermont-Ferrand, France.|EA 4677 'ERTICA', University of Auvergne, 63011 Clermont-Ferrand, France.
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Judes
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 place Henri Dunant, 63001 Clermont-Ferrand, France.|EA 4677 'ERTICA', University of Auvergne, 63011 Clermont-Ferrand, France.
authors.forename: Khaldoun
authors.initials: K
authors.lastname: Rifaï
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 place Henri Dunant, 63001 Clermont-Ferrand, France.|EA 4677 'ERTICA', University of Auvergne, 63011 Clermont-Ferrand, France.
authors.forename: Marjolaine
authors.initials: M
authors.lastname: Ngollo
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 place Henri Dunant, 63001 Clermont-Ferrand, France.|EA 4677 'ERTICA', University of Auvergne, 63011 Clermont-Ferrand, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Daures
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 place Henri Dunant, 63001 Clermont-Ferrand, France.|EA 4677 'ERTICA', University of Auvergne, 63011 Clermont-Ferrand, France.
authors.forename: Yves-Jean
authors.initials: YJ
authors.lastname: Bignon
authors.affiliation: EA 4677 'ERTICA', University of Auvergne, 63011 Clermont-Ferrand, France.|Centre Jean Perrin, Laboratory of Biopathology, 63011 Clermont-Ferrand, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Penault-Llorca
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 place Henri Dunant, 63001 Clermont-Ferrand, France.|EA 4677 'ERTICA', University of Auvergne, 63011 Clermont-Ferrand, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Bernard-Gallon
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D051548:Histone Acetyltransferases / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D000074443:Lysine Acetyltransferase 5; D058990:Molecular Targeted Therapy; D046912:Multiprotein Complexes / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism*; D011485:Protein Binding
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D046912:Multiprotein Complexes; D051548:Histone Acetyltransferases; C098489:KAT5 protein, human; D000074443:Lysine Acetyltransferase 5
keywords: HAT inhibitor; Tip60; acetyltransferase; cancer; oncogene; suppressor of tumor