title: Beneficial effects of dexpanthenol on mesenteric ischemia and reperfusion injury in experimental rat model.
abstract: OBJECTIVE
  It has been reported that intestinal ischemia-reperfusion (I/R) injury results from oxidative stress caused by increased reactive oxygen species. Dexpanthenol (Dxp) is an alcohol analogue with epitelization, anti-inflammatory, antioxidant, and increasing peristalsis activities. In the present study, the aim was to investigate protective and therapeutic effects of Dxp against intestinal I/R injury.
  
  
  METHODS
  Overall, 40 rats were assigned into five groups including one control, one alone Dxp, and three I/R groups (40-min ischemia; followed by 2-h reperfusion). In two I/R groups, Dxp (500 mg/kg, i.m.) was given before or during ischemia. The histopathological findings including apoptotic changes, and also tissue and serum biochemical parameters levels, were determined. Oxidative stress and ileum damage were assessed by biochemical and histological examination. In the control (n = 8) and alone Dxp (n = 8; 500 mg/kg, i.m. of Dxp was given at least 30 min before recording), groups were incised via laparotomy, and electrical activity was recorded from their intestines. In this experiment, the effect of Dxp on the motility of the intestine was examined by analyzing electrical activity.
  
  
  RESULTS
  In ileum, oxidant levels were found to be higher, while antioxidant levels were found to be lower in I/R groups when compared with controls. Dxp approximated high levels of oxidants than those in the control group, while it increased antioxidant values compared with I/R groups. Histopathological changes caused by intestinal I/R injury and histological improvements were observed in both groups given Dxp. In the Dxp group, electrical signal activity markedly increased compared with the control group.
  
  
  CONCLUSIONS
  Here, it was seen that Dxp had protective and therapeutic effects on intestinal I/R injury and gastrointestinal system peristaltism.
authors.affiliation: a Department of Gastroenterology , Medical Faculty, Inonu University , Malatya , Turkey ;
authors.forename: Yasir Furkan
authors.initials: YF
authors.lastname: Cagin
authors.affiliation: a Department of Gastroenterology , Medical Faculty, Inonu University , Malatya , Turkey ;
authors.forename: Yahya
authors.initials: Y
authors.lastname: Atayan
authors.affiliation: b Department of Pathology , Medical Faculty , Inonu University , Malatya , Turkey ;
authors.forename: Nurhan
authors.initials: N
authors.lastname: Sahin
authors.affiliation: c Department of Pharmacology , Medical Faculty , Inonu University , Malatya , Turkey ;
authors.forename: Hakan
authors.initials: H
authors.lastname: Parlakpinar
authors.affiliation: d Department of Physiology , Medical Faculty , Inonu University , Malatya , Turkey ;
authors.forename: Alaadin
authors.initials: A
authors.lastname: Polat
authors.affiliation: e Department of Histology and Embryology , Medical Faculty , Inonu University , Malatya , Turkey ;
authors.forename: Nigar
authors.initials: N
authors.lastname: Vardi
authors.affiliation: f Department of Electrical and Electronics , Inonu University , Malatya , Turkey.
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Tagluk
authors.affiliation: d Department of Physiology , Medical Faculty , Inonu University , Malatya , Turkey ;
authors.forename: Kevser
authors.initials: K
authors.lastname: Tanbek
authors.affiliation: e Department of Histology and Embryology , Medical Faculty , Inonu University , Malatya , Turkey ;
authors.forename: Azibe
authors.initials: A
authors.lastname: Yildiz
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis; D004195:Disease Models, Animal; D005260:Female; D007082:Ileum / Q000187:drug effects / Q000473:pathology*; D065666:Mesenteric Ischemia / Q000188:drug therapy / Q000473:pathology*; D018384:Oxidative Stress; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010205:Pantothenic Acid; C007288:dexpanthenol
keywords: Dexpanthenol; intestinal tissue; ischemia–reperfusion; oxidative stress; rat