title: High-Intensity Focused Ultrasound: Current Status for Image-Guided Therapy.
abstract: Image-guided high-intensity focused ultrasound (HIFU) is an innovative therapeutic technology, permitting extracorporeal or endocavitary delivery of targeted thermal ablation while minimizing injury to the surrounding structures. While ultrasound-guided HIFU was the original image-guided system, MR-guided HIFU has many inherent advantages, including superior depiction of anatomic detail and superb real-time thermometry during thermoablation sessions, and it has recently demonstrated promising results in the treatment of both benign and malignant tumors. HIFU has been employed in the management of prostate cancer, hepatocellular carcinoma, uterine leiomyomas, and breast tumors, and has been associated with success in limited studies for palliative pain management in pancreatic cancer and bone tumors. Nonthermal HIFU bioeffects, including immune system modulation and targeted drug/gene therapy, are currently being explored in the preclinical realm, with an emphasis on leveraging these therapeutic effects in the care of the oncology patient. Although still in its early stages, the wide spectrum of therapeutic capabilities of HIFU offers great potential in the field of image-guided oncologic therapy.
authors.affiliation: Department of Diagnostic Radiology, William Beaumont Hospital, Royal Oak, Michigan.
authors.forename: Alexander
authors.initials: A
authors.lastname: Copelan
authors.affiliation: Case Western Reserve University School of Medicine, Cleveland, Ohio.
authors.forename: Jason
authors.initials: J
authors.lastname: Hartman
authors.affiliation: Department of Diagnostic Radiology, William Beaumont Hospital, Royal Oak, Michigan.
authors.forename: Monzer
authors.initials: M
authors.lastname: Chehab
authors.affiliation: Section of Abdominal Imaging, Department of Diagnostic Radiology, MD Anderson Cancer Center, Houston, Texas.
authors.forename: Aradhana M
authors.initials: AM
authors.lastname: Venkatesan
keywords: HIFU; ablation; focused ultrasound surgery; image guided; interventional oncology; interventional radiology