title: Exploration of Functional Connectivity During Preferred Music Stimulation in Patients with Disorders of Consciousness.
abstract: Preferred music is a highly emotional and salient stimulus, which has previously been shown to increase the probability of auditory cognitive event-related responses in patients with disorders of consciousness (DOC). To further investigate whether and how music modifies the functional connectivity of the brain in DOC, five patients were assessed with both a classical functional connectivity scan (control condition), and a scan while they were exposed to their preferred music (music condition). Seed-based functional connectivity (left or right primary auditory cortex), and mean network connectivity of three networks linked to conscious sound perception were assessed. The auditory network showed stronger functional connectivity with the left precentral gyrus and the left dorsolateral prefrontal cortex during music as compared to the control condition. Furthermore, functional connectivity of the external network was enhanced during the music condition in the temporo-parietal junction. Although caution should be taken due to small sample size, these results suggest that preferred music exposure might have effects on patients auditory network (implied in rhythm and music perception) and on cerebral regions linked to autobiographical memory.
authors.affiliation: Coma Science Group, GIGA & Cyclotron Research Center and Neurology Department, University and University Hospital of Liège Liège, Belgium ; Auditory Cognition and Psychoacoustics Team - Lyon Neuroscience Research Center (UCBL, CNRS, UMR 5292, INSERM U1028) Lyon, France.
authors.forename: Lizette
authors.initials: L
authors.lastname: Heine
authors.affiliation: Auditory Cognition and Psychoacoustics Team - Lyon Neuroscience Research Center (UCBL, CNRS, UMR 5292, INSERM U1028) Lyon, France.
authors.forename: Maïté
authors.initials: M
authors.lastname: Castro
authors.affiliation: Coma Science Group, GIGA & Cyclotron Research Center and Neurology Department, University and University Hospital of Liège Liège, Belgium.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Martial
authors.affiliation: Auditory Cognition and Psychoacoustics Team - Lyon Neuroscience Research Center (UCBL, CNRS, UMR 5292, INSERM U1028) Lyon, France.
authors.forename: Barbara
authors.initials: B
authors.lastname: Tillmann
authors.affiliation: Coma Science Group, GIGA & Cyclotron Research Center and Neurology Department, University and University Hospital of Liège Liège, Belgium.
authors.forename: Steven
authors.initials: S
authors.lastname: Laureys
authors.affiliation: Auditory Cognition and Psychoacoustics Team - Lyon Neuroscience Research Center (UCBL, CNRS, UMR 5292, INSERM U1028) Lyon, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Perrin
keywords: auditory network; disorders of consciousness; external network; fMRI; functional connectivity; music