title: Analysis of OXA23 and AmpCβ-Lactamase Genes in Clinically Isolated Multidrug-Resistant Acinetobacter baumannii Clonal Complex 92.
abstract: Multidrug-resistant Acinetobacter baumannii, which is resistant to carbapenems, amino glycosides, and fluoroquinolones, was isolated from the wound of an outpatient. We performed Multi Locus Sequence Typing and analyzed the structures of the AmpC β-lactamase and OXA23 carbapenemase genes. This strain was assigned as ST451, a member of clonal complex 92, by its MLST scheme. The structures of ISAba1-AmpC β-lactamase and ISAba1-OXA23 carbapenemase were revealed and the major globally prevalent clone of carbapenem-resistant A. baumannii was identified.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yasuhara
authors.forename: Yohei
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Haruka
authors.initials: H
authors.lastname: Kotake
authors.forename: Yurika
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Morishita
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Fukuchi
mesh_terms: D040981:Acinetobacter baumannii / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D001426:Bacterial Proteins / Q000032:analysis / Q000235:genetics*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D016254:Mutagenesis, Insertional; D016133:Polymerase Chain Reaction; D001618:beta-Lactamases / Q000032:analysis / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; C466679:beta-lactamase OXA-23; C048795:AmpC beta-lactamases; D001618:beta-Lactamases