title: Aging is associated with changes to the biomechanical properties of the posterior cerebral artery and parenchymal arterioles.
abstract: Artery remodeling, described as a change in artery structure, may be responsible for the increased risk of cardiovascular disease with aging. Although the risk for stroke is known to increase with age, relatively young animals have been used in most stroke studies. Therefore, more information is needed on how aging alters the biomechanical properties of cerebral arteries. Posterior cerebral arteries (PCAs) and parenchymal arterioles (PAs) are important in controlling brain perfusion. We hypothesized that aged (22-24 mo old) C57bl/6 mice would have stiffer PCAs and PAs than young (3-5 mo old) mice. The biomechanical properties of the PCAs and PAs were assessed by pressure myography. Data are presented as means ± SE of young vs. old. In the PCA, older mice had increased outer (155.6 ± 3.2 vs. 169.9 ± 3.2 μm) and lumen (116.4 ± 3.6 vs. 137.1 ± 4.7 μm) diameters. Wall stress (375.6 ± 35.4 vs. 504.7 ± 60.0 dyn/cm(2)) and artery stiffness (β-coefficient: 5.2 ± 0.3 vs. 7.6 ± 0.9) were also increased. However, wall strain (0.8 ± 0.1 vs. 0.6 ± 0.1) was reduced with age. In the PAs from old mice, wall thickness (3.9 ± 0.3 vs. 5.1 ± 0.2 μm) and area (591.1 ± 95.4 vs. 852.8 ± 100 μm(2)) were increased while stress (758.1 ± 100.0 vs. 587.2 ± 35.1 dyn/cm(2)) was reduced. Aging also increased mean arterial and pulse pressures. We conclude that age-associated remodeling occurs in large cerebral arteries and arterioles and may increase the risk of cerebrovascular disease.
authors.affiliation: Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan diazjani@msu.edu.
authors.forename: Janice M
authors.initials: JM
authors.lastname: Diaz-Otero
authors.affiliation: Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan.
authors.forename: Hannah
authors.initials: H
authors.lastname: Garver
authors.affiliation: Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan.
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Fink
authors.affiliation: Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan.
authors.forename: William F
authors.initials: WF
authors.lastname: Jackson
authors.affiliation: Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Dorrance
mesh_terms: D000375:Aging / Q000473:pathology / Q000502:physiology*; D000818:Animals; D062186:Arterial Pressure / Q000502:physiology*; D001160:Arterioles / Q000473:pathology / Q000503:physiopathology; D001696:Biomechanical Phenomena; D001794:Blood Pressure / Q000502:physiology; D054022:Cerebrum / Q000098:blood supply*; D051379:Mice; D008810:Mice, Inbred C57BL; D009213:Myography; D009929:Organ Size; D020769:Posterior Cerebral Artery / Q000473:pathology / Q000503:physiopathology*; D013314:Stress, Mechanical; D059289:Vascular Stiffness / Q000502:physiology*
keywords: aging; cerebrovascular circulation; remodeling; vasculature