title: The Hypoglycemic and Synergistic Effect of Loganin, Morroniside, and Ursolic Acid Isolated from the Fruits of Cornus officinalis.
abstract: Hypoglycemic activity-guided separation of ethanol extracts from the fruits of Cornus officinalis Sieb. et Zucc (CO) led to the isolation of loganin, morroniside, and ursolic acid. The antidiabetic capacity of CO extracts and related compounds was further investigated in diabetes mellitus mice. The results suggested that both CO extracts and pure compounds could ameliorate diabetes-associated damages and complications. Oral administration of loganin and morroniside decreased fasting blood glucose levels in diabetes mellitus mice. Ursolic acid exhibited the highest reactive oxygen species scavenging activity and α-glucosidase inhibitory activity. Notably, we noticed an interesting synergistic effect between loganin and ursolic acid. Given these favorable hypoglycemic properties, C. officinalis, a food and medicinal plant in China, may be used as a valuable food supplement for the treatment of diabetes mellitus.
authors.affiliation: School of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.|Department of Clinical Laboratory, Hunan University of Medicine, Hunan, 418000, China.|Engineer Research Center of Chongqing Pharmaceutical Process and Quality Control, Chongqing, 400715, China.
authors.forename: Kai
authors.initials: K
authors.lastname: He
authors.affiliation: School of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.|Engineer Research Center of Chongqing Pharmaceutical Process and Quality Control, Chongqing, 400715, China.
authors.forename: Shanghua
authors.initials: S
authors.lastname: Song
authors.affiliation: School of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.|Engineer Research Center of Chongqing Pharmaceutical Process and Quality Control, Chongqing, 400715, China.
authors.forename: Zongyao
authors.initials: Z
authors.lastname: Zou
authors.affiliation: School of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.|College of Environmental and Biological Engineering, Chongqing Technology and Business University, Chongqing, 400067, China.
authors.forename: Min
authors.initials: M
authors.lastname: Feng
authors.affiliation: School of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.|Engineer Research Center of Chongqing Pharmaceutical Process and Quality Control, Chongqing, 400715, China.
authors.forename: Dezhen
authors.initials: D
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.|Engineer Research Center of Chongqing Pharmaceutical Process and Quality Control, Chongqing, 400715, China.
authors.forename: Yanzhi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.|Engineer Research Center of Chongqing Pharmaceutical Process and Quality Control, Chongqing, 400715, China.
authors.forename: Xuegang
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Life Sciences, Southwest University, Chongqing, 400715, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Ye
mesh_terms: D000818:Animals; D002681:China; D029768:Cornus / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D016166:Free Radical Scavengers / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D006027:Glycosides / Q000494:pharmacology*; D056945:Hep G2 Cells; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D039823:Iridoids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000378:metabolism; D014315:Triterpenes / Q000494:pharmacology*; D000520:alpha-Glucosidases / Q000378:metabolism; D000097245:Ursolic Acid
chemical_list: D016166:Free Radical Scavengers; D006027:Glycosides; D007004:Hypoglycemic Agents; D039823:Iridoids; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D014315:Triterpenes; D000520:alpha-Glucosidases; D000097245:Ursolic Acid; C488401:morroniside; C059516:loganin
keywords: Cornus officinalis; hypoglycemic; loganin; morroniside; ursolic acid