title: BLCA1 expression is associated with angiogenesis of bladder cancer and is correlated with common pro-angiogenic factors.
abstract: OBJECTIVE
  To study the association between expression of BLCA1 and clinicopathological parameters of bladder cancer.
  
  
  METHODS
  Seventy-seven bladder cancer tissue samples were collected and primary antibody of BLCA1 was generated via animal inoculation. Immunohistochemical staining of BLCA1 and several pro-angiogenic factors were performed and evaluated semi-quantitatively. Statistical analyses were used to reveal the associations therein.
  
  
  RESULTS
  Expression of BLCA-1 was not associated with tumor characteristics such as occurrence, size, or onset pattern, but was associated with progression of tumor grade, stage, and with muscle invasion. BLCA1 expression was correlated with expression of VEGF, MMP9, IL1α, IL8, and microvessel density (MVD), but not with TNFα expression.
  
  
  CONCLUSIONS
  BLCA1 is associated with progression of bladder cancer and paly a role in angiogenesis in bladder cancer.
authors.affiliation: Department of Urology, Huashan Hospital, Fudan University Shanghai 200040, PR China.
authors.forename: Chenchen
authors.initials: C
authors.lastname: Feng
authors.affiliation: Department of Urology, Huashan Hospital, Fudan University Shanghai 200040, PR China.
authors.forename: Lujia
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Urology, Huashan Hospital, Fudan University Shanghai 200040, PR China.
authors.forename: Guanxiong
authors.initials: G
authors.lastname: Ding
authors.affiliation: Department of Urology, Huashan Hospital, Fudan University Shanghai 200040, PR China.
authors.forename: Haowen
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Urology, Huashan Hospital, Fudan University Shanghai 200040, PR China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ding
authors.affiliation: Department of Urology, Huashan Hospital, Fudan University Shanghai 200040, PR China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wu
keywords: BLCA1; Bladder cancer; angiogenesis