title: HSC Aging and Senescent Immune Remodeling.
abstract: Aging-associated changes in the function of the immune system are referred to as senescent immune remodeling (SIR). Here we review the current understanding on the cellular and molecular mechanisms underlying SIR. We focus on aging-associated changes in T and B cells, and discuss recent evidence supporting the notion that aging of the hematopoietic stem cell (HSC) compartment directly contributes to SIR due to aging-associated alterations in stem cell differentiation. We conclude by outlining strategies to attenuate SIR, including approaches to rejuvenate HSCs, which may open new avenues for targeting SIR in the clinic.
authors.affiliation: Institute for Molecular Medicine, Stem Cells and Aging, Ulm University, Ulm, Germany; aging research center, Ulm University, Ulm, Germany; AGAPLESION Bethesda Clinic, Geriatric Medicine, Ulm University, Ulm, Germany; Geriatric Center Ulm/Alb-Donau, Ulm, Germany.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Denkinger
authors.affiliation: AGAPLESION Bethesda Clinic, Geriatric Medicine, Ulm University, Ulm, Germany; Department of Internal Medicine I, University Hospital of Ulm, Ulm, Germany.
authors.forename: Hanna
authors.initials: H
authors.lastname: Leins
authors.affiliation: Department of Internal Medicine I, University Hospital of Ulm, Ulm, Germany.
authors.forename: Reinhold
authors.initials: R
authors.lastname: Schirmbeck
authors.affiliation: Institute for Molecular Medicine, Stem Cells and Aging, Ulm University, Ulm, Germany; aging research center, Ulm University, Ulm, Germany.
authors.forename: Maria Carolina
authors.initials: MC
authors.lastname: Florian
authors.affiliation: Institute for Molecular Medicine, Stem Cells and Aging, Ulm University, Ulm, Germany; aging research center, Ulm University, Ulm, Germany; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA. Electronic address: hartmut.geiger@uni-ulm.de.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Geiger
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D016922:Cellular Senescence / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology