title: PERSISTENT ORGANOCHLORINE POLLUTANTS IN OBESE WOMEN AFTER DIET INDUCED WEIGHT LOSS: FIVE YEARS FOLLOW UP STUDY.
abstract: OBJECTIVE
  Persistent organochlorine pollutants (POPs) from the environment are still bioaccumulating in human tissues. The aim of our study was to analyze the development of plasma POPs levels in obese women in relationship with their weight loss success in five year follow-up study.
  
  
  METHODS
  20 obese women aged 25-73 years were studied just before and after having completed a 3 month controlled low calorie diet (LCD) intervention (5 MJ daily), and again after 6 and 60 months since the beginning of the study. Body weight and plasma levels of 7 POPs were measured: polychlorinated biphenyls (PCB) 153, 138, 180; 2,2-bis(4-chlorophenyl)-1,1,1-trichloroethylene (p,p'-DDE); 2,2-bis(4-chlorophenyl)-1,1,1-trichloroethane (p,p'-DDT), hexachlorocyclobenzene (HCB), hexachlorocyclohexane β (HCH β).
  
  
  RESULTS
  Data shows that after 3 months of a completely controlled restrictive diet regimen, the weight loss was associated with an increase in POP plasma levels. However, after a five year follow-up, there were no differences in POPs plasma levels between those who kept losing weight or maintained the initial weight (WL/M) and the group of weight gainers (WG), except for HCB where the WG had a significantly higher level (p < 0.05).
  
  
  CONCLUSIONS
  These results suggest that contrary to the long-term weight gain, the long-term weight loss or weight maintenance caused by diet restriction is associated with lower plasma levels of HCB.
authors.forename: Dana
authors.initials: D
authors.lastname: Müllerová
authors.forename: Dagmar
authors.initials: D
authors.lastname: Matějková
authors.forename: Jana
authors.initials: J
authors.lastname: Dvořáková
authors.forename: Luděk
authors.initials: L
authors.lastname: Müller
authors.forename: Jan
authors.initials: J
authors.lastname: Rosmus
authors.forename: Kateřina
authors.initials: K
authors.lastname: Kovářová
mesh_terms: D000328:Adult; D000368:Aged; D004781:Environmental Exposure / Q000032:analysis*; D004785:Environmental Pollutants / Q000097:blood* / Q000493:pharmacokinetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood* / Q000493:pharmacokinetics; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D015431:Weight Loss / Q000502:physiology*
chemical_list: D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated