title: The rs5743708 gene polymorphism in the TLR2 gene contributes to the risk of tuberculosis disease.
abstract: BACKGROUND
  It has been reported that one single nucleotide polymorphisms (SNPs) rs5743708 in TLR2 gene might be associated with the susceptibility to tuberculosis disease. Owing to mixed and inconclusive results, we conducted a meta-analysis to systematically summarize and clarify the association between the rs5743708 gene polymorphism in the TLR2 gene and the risk of tuberculosis disease.
  
  
  METHODS
  A systematic search of studies on the association of the rs5743708 gene polymorphism in the TLR2 gene with susceptibility to tuberculosis disease was conducted in PubMed. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to pool the effect size.
  
  
  RESULTS
  A total of nineteen case-control studies from 13 articles on rs2910164 and 3 studies on the rs5743708 gene polymorphism in the TLR2 gene and the risk of tuberculosis disease were included. A significant relationship between the rs5743708 gene polymorphism in the TLR2 gene and tuberculosis disease was discovered in an allelic genetic model (OR: 2.801, 95% CI: 2.130-3.683, P=0.000), a homozygote model (OR: 5.795, 95% CI: 1.982-16.941, P=0.001), a heterozygote model (OR: 2.628, 95% CI: 1.888-3.569, P=0.000), a dominant genetic model (OR: 2.786, 95% CI: 2.003-3.877, P=0.000) and a recessive genetic model OR: (5.568, 95% CI: 1.907-16.255, P=0.002). In sub-group analysis base on ethnicity, significance was observed between the Caucasian group and the Asian group.
  
  
  CONCLUSIONS
  The rs5743708 gene polymorphism in the TLR2 gene contributes to the risk of tuberculosis disease. Individuals with the rs5743708 gene polymorphism in the TLR2 gene are under a higher risk for tuberculosis disease.
authors.affiliation: Department of Clinical Laboratory Medicine, The Third affiliated Hospital of Guangzhou Medical University Guangzhou 510150, Guangdong, People's Republic of China ; Department of Internal Medicine, The Third Clinical College of Guangzhou Medical University Guangzhou 510150, Guangdong, People's Republic of China ; Department of Clinical Laboratory Medicine, Nanfang Hospital of Southern Medical University Guangzhou 510515, Guangdong, People's Republic of China.
authors.forename: Xu-Guang
authors.initials: XG
authors.lastname: Guo
authors.affiliation: Department of Clinical Laboratory Medicine, The Third affiliated Hospital of Guangzhou Medical University Guangzhou 510150, Guangdong, People's Republic of China ; Department of Internal Medicine, The Third Clinical College of Guangzhou Medical University Guangzhou 510150, Guangdong, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xia
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008957:Models, Genetic; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D044469:Racial Groups / Q000235:genetics; D018570:Risk Assessment; D012307:Risk Factors; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D014376:Tuberculosis / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000382:microbiology
chemical_list: C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2
keywords: TLR2; gene polymorphism; rs5743708; tuberculosis disease