title: Lingual Malignant Peripheral Nerve Sheath Tumor in a Chinese Pug Dog.
abstract: A 9-year-old spayed/female Chinese Pug dog presented for evaluation of a mass located on the rostral aspect of the tongue. An incisional biopsy was acquired, submitted, and interpreted as a possible granular cell tumor based on hematoxylin and eosin, and periodic acid Schiff histopathologic staining characteristics. The diagnosis was supported by immunohistochemical evaluation that was positive for S-100, vimentin, and neuron-specific enolase. Based on the absence of mitotic figures in the incisional biopsy, a partial glossectomy was performed with gross margins of at least 1-cm. The excisional biopsy revealed significant features of malignancy, with neoplastic cells in close association with peripheral nerves, consistent with malignant peripheral nerve sheath tumor. Tumor-free margins were obtained, and the glossectomy had expected healing with no recurrence apparent 6-months following surgery.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Baratt
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rawlinson
authors.forename: Lois
authors.initials: L
authors.lastname: Roth-Johnson
authors.forename: Carroll J
authors.initials: CJ
authors.lastname: Jones
mesh_terms: D000818:Animals; D001706:Biopsy / Q000662:veterinary; D004283:Dog Diseases / Q000209:etiology / Q000473:pathology / Q000601:surgery; D004285:Dogs; D005260:Female; D018317:Nerve Sheath Neoplasms / Q000209:etiology / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D009442:Neurilemmoma / Q000209:etiology / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D016896:Treatment Outcome