title: Fabrication of a Flexible Amperometric Glucose Sensor Using Additive Processes.
abstract: This study details the use of printing and other additive processes to fabricate a novel amperometric glucose sensor. The sensor was fabricated using a Au coated 12.7 μm thick polyimide substrate as a starting material, where micro-contact printing, electrochemical plating, chloridization, electrohydrodynamic jet (e-jet) printing, and spin coating were used to pattern, deposit, chloridize, print, and coat functional materials, respectively. We have found that e-jet printing was effective for the deposition and patterning of glucose oxidase inks with lateral feature sizes between ~5 to 1000 μm in width, and that the glucose oxidase was still active after printing. The thickness of the permselective layer was optimized to obtain a linear response for glucose concentrations up to 32 mM and no response to acetaminophen, a common interfering compound, was observed. The use of such thin polyimide substrates allow wrapping of the sensors around catheters with high radius of curvature ~250 μm, where additive and microfabrication methods may allow significant cost reductions.
authors.affiliation: School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, Oregon 97331, USA.
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Du
authors.affiliation: School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, Oregon 97331, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Durgan
authors.affiliation: School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, Oregon 97331, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Matthews
authors.affiliation: School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, Oregon 97331, USA.
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Motley
authors.affiliation: School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, Oregon 97331, USA.
authors.forename: Xuebin
authors.initials: X
authors.lastname: Tan
authors.affiliation: School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, Oregon 97331, USA.
authors.forename: Kovit
authors.initials: K
authors.lastname: Pholsena
authors.affiliation: School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, Oregon 97331, USA.
authors.forename: Líney
authors.initials: L
authors.lastname: Árnadóttir
authors.affiliation: Pacific Diabetes Technologies, Portland, Oregon 97201, USA.
authors.forename: Jessica R
authors.initials: JR
authors.lastname: Castle
authors.affiliation: Pacific Diabetes Technologies, Portland, Oregon 97201, USA ; Oregon Health & Science University, Portland, Oregon 97239, USA.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Jacobs
authors.affiliation: Pacific Diabetes Technologies, Portland, Oregon 97201, USA.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Cargill
authors.affiliation: Pacific Diabetes Technologies, Portland, Oregon 97201, USA.
authors.forename: W Kenneth
authors.initials: WK
authors.lastname: Ward
authors.affiliation: School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, Oregon 97331, USA.
authors.forename: John F
authors.initials: JF
authors.lastname: Conley
authors.affiliation: School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, Oregon 97331, USA.
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Herman