title: Salivary markers of kidney function - Potentials and limitations.
abstract: Saliva can be collected non-invasively, repeatedly and without trained personnel. It is a promising diagnostic body fluid with clinical use in endocrinology and dentistry. For decades, it is known that saliva contains also urea, creatinine and other markers of renal function. Clinical studies have shown that the salivary concentrations of these markers could be useful for the assessment of kidney function without the need of blood collection. This article summarizes the clinical and experimental data on the use of saliva as a diagnostic fluid in nephrology and points out the advantages, pitfalls, technical requirements and future perspective for the use of saliva as a novel potential diagnostic biofluid.
authors.affiliation: Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; Center for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovakia; Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia; Department of Molecular Biology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia. Electronic address: petercelec@gmail.com.
authors.forename: Peter
authors.initials: P
authors.lastname: Celec
authors.affiliation: Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; Center for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovakia.
authors.forename: Ľubomíra
authors.initials: Ľ
authors.lastname: Tóthová
authors.affiliation: Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors.forename: Katarína
authors.initials: K
authors.lastname: Šebeková
authors.affiliation: 1st Department of Pediatrics, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors.forename: Ľudmila
authors.initials: Ľ
authors.lastname: Podracká
authors.affiliation: Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; Institute of Pathology & Department of Nephrology, RWTH Aachen University, Aachen, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Boor
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D007677:Kidney Function Tests / Q000379:methods*; D010518:Periodontitis / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D012463:Saliva / Q000378:metabolism*; D014987:Xerostomia / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology
chemical_list: D015415:Biomarkers
keywords: Biomarkers; Nephropathy; Renal failure; Saliva; Urea