title: D14 repeat polymorphism of the asporin gene is associated with primary osteoarthritis of the knee in a Mexican Mestizo population.
abstract: BACKGROUND
  Asporin is a novel extracellular matrix protein (ECM) with an important role in the development of osteoarthritis (OA), because it has been reported that functional polymorphisms in the aspartic acid repeat (D) of the asporin gene (ASPN) are associated with susceptibility to OA.
  
  
  OBJECTIVE
  This study was planned to investigate the association of the ASPN polymorphism with primary OA of the knee in a Mexican population, including several countryside regions.
  
  
  METHODS
  We conducted a case-control study in which 93 cases with primary OA of the knee and 118 controls were included. Cases included patients > 40 years of age, with a body mass index (BMI) ≤ 27 and a radiologic score for OA of the knee of ≥ 2. Controls were subjects > 40 years of age with a radiologic score of < 2. The D repeat polymorphism was genotyped and logistic regression was developed to evaluate risk magnitude.
  
  
  RESULTS
  The D14 allele was more common in our cases and was associated with an increased risk for developing OA, while the frequencies of the remaining alleles did not exhibit differences.
  
  
  CONCLUSIONS
  Our data suggest that the D14 allele of the ASPN polymorphism could exert an influence on primary OA of the knee etiology in a Mexican Mestizo population.
authors.affiliation: Department of Genetics, Instituto Nacional de Rehabilitación (INR), México City, México.
authors.forename: Norma Celia
authors.initials: NC
authors.lastname: González-Huerta
authors.affiliation: Department of Genetics, Instituto Nacional de Rehabilitación (INR), México City, México.
authors.forename: Verónica Marusa
authors.initials: VM
authors.lastname: Borgonio-Cuadra
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autónoma de México (UNAM), México City, México.|Department of Genetics, Instituto de Oftalmología "Conde de Valenciana", México City, México.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Zenteno
authors.affiliation: Department of Magnetic Resonance, Instituto Nacional de Rehabilitación (INR), México City, México.
authors.forename: Socorro
authors.initials: S
authors.lastname: Cortés-González
authors.affiliation: Department of Rheumatology, Instituto Nacional de Rehabilitación (INR), México City, México.
authors.forename: Carolina
authors.initials: C
authors.lastname: Duarte-Salazar
authors.affiliation: Department of Genetics, Instituto Nacional de Rehabilitación (INR), México City, México.
authors.forename: Antonio
authors.initials: A
authors.lastname: Miranda-Duarte
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000208:ethnology / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D020449:Repetitive Sequences, Amino Acid; D012307:Risk Factors
chemical_list: C439889:ASPN protein, human; D016326:Extracellular Matrix Proteins
keywords: Mexican Mestizo population; asporin gene; association study; osteoarthritis of the knee