title: Development of PEGylated solid lipid nanoparticles of pentoxifylline for their beneficial pharmacological potential in pathological cardiac hypertrophy.
abstract: OBJECTIVE
  The present study was designed to develop PEGylated solid lipid nanoparticles (SLNs) of pentoxifylline (with increased t½) for the management of cardiac hypertrophy.
  
  
  METHODS
  PEGylated SLNs were prepared by melt emulsification method and characterised by zeta potential, polydispersity index, entrapment efficiency, in vitro release and pharmacokinetic profile. Hypertrophy was assessed as increase in tumour necrosis factor-alpha, mean arterial blood pressure, LV protein content and left ventricular end diastolic pressure.
  
  
  RESULTS
  PEGylated SLNs (F19) with increased t½ were developed and characterised. F19 attenuates hypertrophy assessed in terms of parameters employed.
  
  
  CONCLUSIONS
  Thus, PEGylated SLNs (F19) of pentoxifylline have enhanced t½and consequently more significantly preclude cardiac hypertrophy as compared to pentoxifylline.
authors.affiliation: a Department of Pharmacology , ISF college of Pharmacy , Moga , Punjab , India.
authors.forename: Sunny
authors.initials: S
authors.lastname: Dhiman
authors.affiliation: b Department of Pharmaceutics , ISF college of Pharmacy , Moga , Punjab , India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Mishra
authors.affiliation: a Department of Pharmacology , ISF college of Pharmacy , Moga , Punjab , India.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Sharma
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D008055:Lipids / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D010431:Pentoxifylline / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008055:Lipids; D011092:Polyethylene Glycols; D010431:Pentoxifylline; C000595209:polyethylene glycol 1000
keywords: PEGylation; cardiac remodelling; circulation; left ventricle; nanoparticles; pentoxifylline