title: Use of Autometallography in Studies of Nanosilver Distribution and Toxicity.
abstract: With the increasing use of and interest in nanoparticles in medicine and technology, the tissue and cell-specific localization of the particles are important considerations when the nanomaterials find their way into biological systems. This brief communication shows the utility of autometallography in determining the location of metal deposition at the light microscopic level. Although primarily focusing on studies of the toxicity and deposition of silver nanoparticles, use of autometallography to localize zinc and other metals at the tissue and subcellular localization is also recognized.
authors.affiliation: Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Miller
authors.affiliation: Institute of Nanoproduct Safety Research, Hoseo University, Asan, Korea.
authors.forename: Il Je
authors.initials: IJ
authors.lastname: Yu
authors.affiliation: Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA marybeth.genter@uc.edu.
authors.forename: Mary Beth
authors.initials: MB
authors.lastname: Genter
mesh_terms: D000818:Animals; D008168:Lung / Q000378:metabolism; D008297:Male; D053768:Metal Nanoparticles / Q000633:toxicity; D051381:Rats; D012834:Silver / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: D012834:Silver
keywords: autometallography; silver nanoparticles