title: Activity of Heme Synthesis Enzymes in the Bone Marrow and Liver of August and Wistar Rats During the Neonatal Period and After Acute Postnatal Hypoxia.
abstract: Activity of heme synthesis enzymes in newborn August and Wistar rats was studied after acute hypoxic hypoxia. Daily production of erythrocytes and activities of aminolevulinate synthase, aminolevulinate dehydratase, and heme synthetase were measured in the bone marrow (15-30 min after birth and on days 1 and 3 of life) and liver (day 3 after birth). Hypoxia was followed by a decrease in activity of heme synthesis enzymes in the liver (especially in August rats) and reduction of the daily erythrocyte production (especially in Wistar rats). Our results suggest that the response of heme synthesis enzymes to hypoxic exposure in newborn rats is genetically determined. The observed changes are more pronounced in Wistar rats.
authors.affiliation: Research Center for Problems of Family Health and Human Reproduction, Irkutsk, Russia. sikolesnikov2012@gmail.com.|M. V. Lomonosov Moscow State University, Moscow, Russia. sikolesnikov2012@gmail.com.
authors.forename: S I
authors.initials: SI
authors.lastname: Kolesnikov
authors.affiliation: Municipal Clinical Hospital No. 6, Moscow, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Popova
authors.affiliation: South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Krupitskaya
authors.affiliation: South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Sinitskii
authors.affiliation: Research Center for Problems of Family Health and Human Reproduction, Irkutsk, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Kolesnikova
mesh_terms: D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001853:Bone Marrow / Q000201:enzymology*; D005294:Ferrochelatase / Q000378:metabolism; D000860:Hypoxia / Q000201:enzymology; D008099:Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar
chemical_list: D006899:Mixed Function Oxygenases; D000624:5-Aminolevulinate Synthetase; D005294:Ferrochelatase
keywords: August and Wistar rats; acute hypoxia; heme synthesis enzymes; neonatal period