title: Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64.
abstract: A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, (64)Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A).
authors.affiliation: Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University , Daegu 700-422, South Korea.
authors.forename: Nikunj
authors.initials: N
authors.lastname: Bhatt
authors.affiliation: Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University , Daegu 700-422, South Korea.
authors.forename: Nisarg
authors.initials: N
authors.lastname: Soni
authors.affiliation: Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University , Daegu 700-422, South Korea.
authors.forename: Yeong Su
authors.initials: YS
authors.lastname: Ha
authors.affiliation: Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University , Daegu 700-422, South Korea.
authors.forename: Woonghee
authors.initials: W
authors.lastname: Lee
authors.affiliation: Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University , Daegu 700-422, South Korea.
authors.forename: Darpan N
authors.initials: DN
authors.lastname: Pandya
authors.affiliation: Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University , Daegu 700-422, South Korea.
authors.forename: Swarbhanu
authors.initials: S
authors.lastname: Sarkar
authors.affiliation: Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences , Seoul 139-706, South Korea.
authors.forename: Jung Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Energy Systems Engineering, Daegu Gyeongbuk Institute of Science & Technology , Daegu 711-873, South Korea.
authors.forename: Hochun
authors.initials: H
authors.lastname: Lee
authors.affiliation: Western Seoul Center, Korea Basic Science Institute , Seoul 120-140, Korea.
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences , Seoul 139-706, South Korea.
authors.forename: Gwang Il
authors.initials: GI
authors.lastname: An
authors.affiliation: Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University , Daegu 700-422, South Korea.
authors.forename: Jeongsoo
authors.initials: J
authors.lastname: Yoo
keywords: Bifunctional chelator; phosphonate pendant arms; propylene cross bridge; radiopharmaceuticals