title: Is urine intercellular adhesion molecule-1 a marker of renal disorder in children with ureteropelvic junction obstruction?
abstract: OBJECTIVE
  We aimed to investigate whether urine intercellular adhesion molecule-1 (ICAM-1) might serve as a marker of renal disorder in children with ureteropelvic junction obstruction.
  
  
  METHODS
  Twenty-nine children with severe hydronephrosis (HN) were compared with 23 participants with mild HN and with 19 healthy peers.
  
  
  RESULTS
  Urine ICAM-1/uCre levels were significantly higher in HN children than healthy controls (P<0.01), and in severe HN when compared with mild HN (p<0.05).
  
  
  CONCLUSIONS
  It seemed to us that uICAM-1 is a biomarker of renal disorder, and might have the potential to predict which patients will require surgery.
authors.affiliation: a Department of Pediatrics and Nephrology , Medical University of Białystok , Białystok , Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Taranta-Janusz
authors.affiliation: a Department of Pediatrics and Nephrology , Medical University of Białystok , Białystok , Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Wasilewska
authors.affiliation: a Department of Pediatrics and Nephrology , Medical University of Białystok , Białystok , Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Roszkowska
authors.affiliation: a Department of Pediatrics and Nephrology , Medical University of Białystok , Białystok , Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Michaluk-Skutnik
mesh_terms: D000704:Analysis of Variance; D015415:Biomarkers / Q000652:urine*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000175:diagnosis / Q000652:urine; D007223:Infant; D018799:Intercellular Adhesion Molecule-1 / Q000652:urine*; D007674:Kidney Diseases / Q000175:diagnosis / Q000652:urine*; D008297:Male; D011379:Prognosis; D012372:ROC Curve; D012720:Severity of Illness Index; D014517:Ureteral Obstruction / Q000175:diagnosis / Q000652:urine*
chemical_list: D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1
keywords: Hydronephrosis; marker; renal disorder