title: Myoepithelial cells in canine mammary tumours.
abstract: Mammary tumours are the most common neoplasms of female dogs. Compared to mammary tumours of humans and cats, myoepithelial (ME) cell involvement is common in canine mammary tumours (CMT) of any subtype. Since ME cell involvement in CMT influences both histogenetic tumour classification and prognosis, correct identification of ME cells is important. This review describes immunohistochemical methods for identification of canine mammary ME cells used in vivo. In addition, phenotypic and genotypic methods to isolate ME cells for in vitro studies to analyse tumour-suppressor protein production and gene expression are discussed. The contribution of ME cells to both histogenetic classifications and the prognosis of CMT is compared with other species and the potential use of ME cells as a method to identify carcinoma in situ is discussed.
authors.affiliation: Department of Comparative Pathology, University of Córdoba, 14014 Córdoba, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Sánchez-Céspedes
authors.affiliation: Department of Comparative Pathology, University of Córdoba, 14014 Córdoba, Spain.
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Millán
authors.affiliation: Department of Comparative Pathology, University of Córdoba, 14014 Córdoba, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Guil-Luna
authors.affiliation: Department of Pathology, University of Córdoba, 14071 Córdoba, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Reymundo
authors.affiliation: Unit of Histology and Animal Pathology, Institute for Animal Health, Veterinary School, University of Las Palmas de Gran Canaria, 35413 Las Palmas, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Espinosa de Los Monteros
authors.affiliation: Department of Comparative Pathology, University of Córdoba, 14014 Córdoba, Spain. Electronic address: an1magoj@uco.es.
authors.forename: Juana
authors.initials: J
authors.lastname: Martín de Las Mulas
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004847:Epithelial Cells; D005260:Female; D006801:Humans; D008321:Mammary Glands, Animal / Q000473:pathology; D015674:Mammary Neoplasms, Animal / Q000473:pathology*
keywords: Canine; Identification; Mammary gland; Myoepithelial cells; Prognosis; Tumour