title: Systolic aortic pressure-time area is a useful index describing arterial wave properties in rats with diabetes.
abstract: The accurate measurement of arterial wave properties in terms of arterial wave transit time (τw) and wave reflection factor (Rf) requires simultaneous records of aortic pressure and flow signals. However, in clinical practice, it will be helpful to describe the pulsatile ventricular afterload using less-invasive parameters if possible. We investigated the possibility of systolic aortic pressure-time area (PTAs), calculated from the measured aortic pressure alone, acting as systolic workload imposed on the rat diabetic heart. Arterial wave reflections were derived using the impulse response function of the filtered aortic input impedance spectra. The cardiovascular condition in the rats with either type 1 or type 2 diabetes was characterized by (1) an elevation in PTAs; and (2) an increase in Rf and decrease in τw. We found that an inverse linear correlation between PTAs and arterial τw reached significance (τw = 38.5462 - 0.0022 × PTAs; r = 0.7708, P < 0.0001). By contrast, as the PTAs increased, the reflection intensity increased: Rf = -0.5439 + 0.0002 × PTAs; r = 0.8701; P <0 .0001. All these findings suggested that as diabetes stiffened aortas, the augmented aortic PTAs might act as a useful index describing the diabetes-related deterioration in systolic ventricular workload.
authors.affiliation: Department of Physiology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan.
authors.forename: Ru-Wen
authors.initials: RW
authors.lastname: Chang
authors.affiliation: Department of Emergency Medicine, National Taiwan University Hospital, Chu-Tung Branch, Hsin-Chu, 310, Taiwan.
authors.forename: Chun-Yi
authors.initials: CY
authors.lastname: Chang
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, Taipei, 100, Taiwan.
authors.forename: Ming-Shiou
authors.initials: MS
authors.lastname: Wu
authors.affiliation: Department of Surgery, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, 300, Taiwan.
authors.forename: Hsi-Yu
authors.initials: HY
authors.lastname: Yu
authors.affiliation: Department of Surgery, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, 300, Taiwan.
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Luo
authors.affiliation: Department of Surgery, National Taiwan University Hospital, Taipei, 100, Taiwan.
authors.forename: Yih-Sharng
authors.initials: YS
authors.lastname: Chen
authors.affiliation: Department of Surgery, National Taiwan University Hospital, Taipei, 100, Taiwan.
authors.forename: Fang-Yue
authors.initials: FY
authors.lastname: Lin
authors.affiliation: Department of Physiology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan.
authors.forename: Liang-Chuan
authors.initials: LC
authors.lastname: Lai
authors.affiliation: Department of Surgery, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, 300, Taiwan.|Department of Surgery, National Taiwan University Hospital, Taipei, 100, Taiwan.
authors.forename: Chih-Hsien
authors.initials: CH
authors.lastname: Wang
authors.affiliation: Department of Physiology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan.
authors.forename: Kuo-Chu
authors.initials: KC
authors.lastname: Chang
mesh_terms: D000818:Animals; D001011:Aorta / Q000503:physiopathology*; D001794:Blood Pressure; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar