title: Unprecedented copper-mediated oxidative demethylation of propionamides via bidentate-chelation assistance.
abstract: A copper-mediated directed demethylation of propionamides has been developed. This reaction proceeds predominantly at the α-methyl groups of aliphatic amides with high efficiency and provides a unique tool for the direct cleavage of unactivated C(sp(3))-C(sp(3)) bonds. The directing groups can be smoothly removed to afford the corresponding alkyl carboxylic acids.
authors.affiliation: iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, Department of Chemistry, University of Science and Technology of China, Hefei 230026, China. binxiao@ustc.edu.cn fuyao@ustc.edu.cn.
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Liu
authors.affiliation: iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, Department of Chemistry, University of Science and Technology of China, Hefei 230026, China. binxiao@ustc.edu.cn fuyao@ustc.edu.cn.
authors.forename: Mian
authors.initials: M
authors.lastname: Cui
authors.affiliation: iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, Department of Chemistry, University of Science and Technology of China, Hefei 230026, China. binxiao@ustc.edu.cn fuyao@ustc.edu.cn.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Lu
authors.affiliation: iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, Department of Chemistry, University of Science and Technology of China, Hefei 230026, China. binxiao@ustc.edu.cn fuyao@ustc.edu.cn.
authors.forename: Zhen-Qi
authors.initials: ZQ
authors.lastname: Zhang
authors.affiliation: iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, Department of Chemistry, University of Science and Technology of China, Hefei 230026, China. binxiao@ustc.edu.cn fuyao@ustc.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Xiao
authors.affiliation: iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, Department of Chemistry, University of Science and Technology of China, Hefei 230026, China. binxiao@ustc.edu.cn fuyao@ustc.edu.cn.
authors.forename: Yao
authors.initials: Y
authors.lastname: Fu