title: Illuminating the Properties of Prostate Luminal Progenitors.
abstract: The identification of tumor-initiating cells represents a significant challenge for studies of prostate cancer. In a recent issue of Cell Reports, Agarwal and colleagues use organoid culture to ascertain two distinct luminal progenitors in a mouse model of prostate cancer, shedding new light on lineage relationships in the prostate epithelium.
authors.affiliation: Departments of Medicine, Genetics and Development, Urology, and Systems Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: mshen@columbia.edu.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Shen
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004847:Epithelial Cells / Q000166:cytology; D004848:Epithelium; D006801:Humans; D008297:Male; D014411:Neoplastic Stem Cells; D009940:Organoids; D011467:Prostate / Q000166:cytology*; D011471:Prostatic Neoplasms