title: Curcumin nanoparticles attenuate cardiac remodeling due to pulmonary arterial hypertension.
abstract: Herein, we investigate whether curcumin nanoparticles (Cur NPs) are effective for the treatment of monocrotaline (MCT)-induced pulmonary arterial hypertension in Sprague Dawley rat. Echocardiography was performed at the start of the study and 28 days after MCT injection. Compared to MCT only animals, Cur NP administration was associated with reduced right ventricular (RV) wall thickness and a decreased right ventricle weight/body weight ratio. Cur NPs also attenuated MCT induced increase in RV mRNA expression of TNF-α and IL-1β. These changes were also associated with decreased RV expression of nitrotyrosine, fibronectin and myosin heavy chain-β.
authors.affiliation: a Center for Diagnostic Nanosystems , Marshall University , Huntington , WV , USA.|b School of Kinesiology , College of Health Professions, Marshall University , Huntington , WV , USA.|c Biotechnology Department, West Virginia State University , Institute , WV , USA.|d Department of Internal Medicine , Joan C. Edwards School of Medicine, Marshall University , Huntington , WV , USA.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Rice
authors.affiliation: a Center for Diagnostic Nanosystems , Marshall University , Huntington , WV , USA.|e Department of Public Health , College of Health Professions, Marshall University , Huntington , WV , USA.
authors.forename: Nandini D P K
authors.initials: ND
authors.lastname: Manne
authors.affiliation: a Center for Diagnostic Nanosystems , Marshall University , Huntington , WV , USA.|f Department of Pharmacology , Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University , Huntington , WV , USA.
authors.forename: Madhukar B
authors.initials: MB
authors.lastname: Kolli
authors.affiliation: g Department of Cardiology , Joan C. Edwards School of Medicine, Marshall University , Huntington , WV , USA.
authors.forename: Paulette S
authors.initials: PS
authors.lastname: Wehner
authors.affiliation: g Department of Cardiology , Joan C. Edwards School of Medicine, Marshall University , Huntington , WV , USA.
authors.forename: Lucy
authors.initials: L
authors.lastname: Dornon
authors.affiliation: a Center for Diagnostic Nanosystems , Marshall University , Huntington , WV , USA.
authors.forename: Ravikumar
authors.initials: R
authors.lastname: Arvapalli
authors.affiliation: a Center for Diagnostic Nanosystems , Marshall University , Huntington , WV , USA.
authors.forename: Vellaisamy
authors.initials: V
authors.lastname: Selvaraj
authors.affiliation: h Department of Clinical Laboratory Sciences , University of Delaware , Newark , DE , USA.
authors.forename: Arun
authors.initials: A
authors.lastname: Kumar
authors.affiliation: a Center for Diagnostic Nanosystems , Marshall University , Huntington , WV , USA.|b School of Kinesiology , College of Health Professions, Marshall University , Huntington , WV , USA.|c Biotechnology Department, West Virginia State University , Institute , WV , USA.|f Department of Pharmacology , Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University , Huntington , WV , USA.|i Department of Pharmaceutical Sciences and Research , Marshall University School of Pharmacy , Huntington , WV , USA.
authors.forename: Eric R
authors.initials: ER
authors.lastname: Blough
mesh_terms: D000818:Animals; D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology; D006352:Heart Ventricles / Q000378:metabolism / Q000503:physiopathology; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D053583:Interleukin-1beta / Q000096:biosynthesis; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D020257:Ventricular Remodeling / Q000187:drug effects*
chemical_list: C000594089:IL1B protein, rat; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D003474:Curcumin
keywords: Cardiac hypertrophy; curcumin; nanoparticles; pulmonary arterial hypertension