title: Cerebral Glucose Metabolism Assessment in Rat Models of Alzheimer's Disease: An 18F-FDG-PET Study.
abstract: This study was designed to detect the brain glucose metabolism in rat models of Alzheimer's disease (AD) by the application of (18)F-2-fluoro-deoxy-d-glucose positron emission tomography ((18)F-FDG-PET) and to provide new insights for the early detection of AD.
  
  
  
  Forty Wistar rats were randomly divided into 2 groups. Fifteen sham-operated rats were used as a control group. The remaining rats as a premodel group were intracerebroventricularly injected with ibotenic acid and were intraperitoneally injected with d-galactose, of which 15 rats were included as the experimental group. The above-mentioned 2 groups were assigned to Y-maze test and underwent (18)F-FDG-PET scanning. Positron emission tomography images were processed with SPM 2.0.
  
  
  
  The learning and memory skills were weakened in AD rats. Besides, the glucose metabolic activity of AD rats decreased in hippolampus, hypothalamus, insular cortex, piriform cortex, striatum, cingulate gyrus, stria terminalis, and parietal lobe and increased in olfactory bulb, cerebellum, midbrain, pontine, and retrosplenial cortex compared with the control group. Dorsal thalamus had shown both enhanced and reduced glucose metabolic activity.
  
  
  
  Our data indicate that the changed glucose metabolism in cerebral regions in (18)F-FDG-PET imaging could be an important predictor for early AD.
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China Department of Traditional Chinese Medicine, Guangdong Medical College, Dongguan, China.
authors.forename: Yangjia
authors.initials: Y
authors.lastname: Lu
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Acupuncture and Massage, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China Department of Acupuncture and Moxibustion, Futian TCM Hospital, Shenzhen, China.
authors.forename: Shaoyang
authors.initials: S
authors.lastname: Cui
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China Department of Rehabilitation, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Junqi
authors.initials: J
authors.lastname: Chen
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China nanfanglihuang@163.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Traditional Chinese Medicine, Guangdong Medical College, Dongguan, China jordan64@163.com.
authors.forename: Chunzhi
authors.initials: C
authors.lastname: Tang
authors.affiliation: Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China.
authors.forename: Baoci
authors.initials: B
authors.lastname: Shan
authors.affiliation: Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China.
authors.forename: Bingbing
authors.initials: B
authors.lastname: Nie
authors.affiliation: Department of Acupuncture and Massage, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
authors.forename: Lai
authors.initials: L
authors.lastname: Xinsheng
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose
keywords: Alzheimer’s disease; PET; metabolism; rat model