title: A novel combination of triple metachronous malignancies of the kidney, oropharynx and prostate: A case report.
abstract: Synchronous or metachronous malignancies are a rare event, with an incidence rate that increases with age. The present study reports the case of a 70-year-old Caucasian male who was referred to the outpatient office of the Urology Unit, Sapienza University of Rome (Latina, Italy) due to lower urinary tract symptoms. An abdominal ultrasound investigation was performed that demonstrated the presence of a right renal mass. The patient underwent right radical nephrectomy, which resulted in the definitive diagnosis of clear cell type renal cell carcinoma. The patient was eventually diagnosed with triple primary metachronous cancer consisting of renal clear cell carcinoma, prostate adenocarcinoma and squamous cell carcinoma of the oropharynx (palatine tonsil). To the best of our knowledge, this combination of primary neoplasms has not previously been documented.
authors.affiliation: Urology Unit, ICOT, Department of Medico‑Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Latina 04100, Italy.
authors.forename: Antonio Luigi
authors.initials: AL
authors.lastname: Pastore
authors.affiliation: Urology Unit, ICOT, Department of Medico‑Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Latina 04100, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Palleschi
authors.affiliation: Urology Unit, ICOT, Department of Medico‑Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Latina 04100, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Leto
authors.affiliation: Urology Unit, ICOT, Department of Medico‑Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Latina 04100, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Silvestri
authors.affiliation: Histopathology Unit, ICOT, Department of Medico‑Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Latina 04100, Italy.
authors.forename: Natale
authors.initials: N
authors.lastname: Porta
authors.affiliation: Histopathology Unit, ICOT, Department of Medico‑Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Latina 04100, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Petrozza
authors.affiliation: Urology Unit, ICOT, Department of Medico‑Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Latina 04100, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Carbone
keywords: palatine tonsil cancer; prostate cancer; renal cancer