title: Lactococcus lactis subsp. lactis JCM 5805 activates natural killer cells via dendritic cells.
abstract: Lactococcus lactis subsp. lactis JCM 5805 (JCM5805) has been shown to stimulate plasmacytoid dendritic cells (pDC). Here, we investigated the effect of JCM5805 on NK cells. In vitro studies suggested that JCM5805 activated natural killer (NK) cells via dendritic cells including pDC. Furthermore, the oral administration of JCM5805 enhanced the cytotoxic activity of NK cells.
authors.affiliation: a Central Laboratories for Key Technologies , Kirin Co., Ltd. , Yokohama , Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: a Central Laboratories for Key Technologies , Kirin Co., Ltd. , Yokohama , Japan.
authors.forename: Konomi
authors.initials: K
authors.lastname: Ohshio
authors.affiliation: a Central Laboratories for Key Technologies , Kirin Co., Ltd. , Yokohama , Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Fujiwara
mesh_terms: D000818:Animals; D018920:Coculture Techniques; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D007694:Killer Cells, Natural / Q000276:immunology*; D013294:Lactococcus lactis / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL
keywords: Lactococcus lactis; dendritic cells; natural killer cells