title: Glutathione-triggered activation of the model of pro-oligonucleotide with benzyl protecting groups at the internucleotide linkage.
abstract: We have examined substituted benzyl protecting groups for the phosphodiester in oligodeoxyribonucleotides. Stability of the protecting groups in buffer and rates of deprotection by glutathione (GSH) were strongly influenced by benzyl ring substituents.
authors.affiliation: Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan. Electronic address: saneyoshih@kanagawa-u.ac.jp.
authors.forename: Hisao
authors.initials: H
authors.lastname: Saneyoshi
authors.affiliation: Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kondo
authors.affiliation: Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Sagawa
authors.affiliation: Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan. Electronic address: akiraono@kanagawa-u.ac.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Ono
mesh_terms: D001593:Benzyl Compounds / Q000737:chemistry / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry / Q000378:metabolism*; D011355:Prodrugs / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001593:Benzyl Compounds; D009838:Oligodeoxyribonucleotides; D011355:Prodrugs; D005978:Glutathione
keywords: Glutathione; Nucleic acid-based therapeutics; Prodrug; Protecting group