title: Gene Therapy for the Treatment of Neurological Disorders: Central Nervous System Neoplasms.
abstract: Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults with a median survival of 16.2-21.2 months post diagnosis (Stupp et al., N Engl J Med 352(10): 987-996, 2005). Because of its location, complete surgical resection is impossible; additionally because GBM is also resistant to chemotherapeutic and radiotherapy approaches, development of novel therapies is urgently needed. In this chapter we describe the development of preclinical animal models and a conditionally cytotoxic and immune-stimulatory gene therapy strategy that successfully causes tumor regression in several rodent GBM models.
authors.affiliation: Department of Neurosurgery, The University of Michigan School of Medicine, MSRB II, RM 4570C, 1150 West Medical Center Drive, Ann Arbor, MI, 48109-5689, USA.|Department of Cell and Developmental Biology, The University of Michigan School of Medicine, MSRB II, RM 4570C, 1150 West Medical Center Drive, Ann Arbor, MI, 48109-5689, USA.
authors.forename: Neha
authors.initials: N
authors.lastname: Kamran
authors.affiliation: Instituto de Investigaciones Biomédicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 10, C1121ABG, Buenos Aires, Argentina.
authors.forename: Marianela
authors.initials: M
authors.lastname: Candolfi
authors.affiliation: Department of Neurosurgery, The University of Michigan School of Medicine, MSRB II, RM 4570C, 1150 West Medical Center Drive, Ann Arbor, MI, 48109-5689, USA.|Department of Cell and Developmental Biology, The University of Michigan School of Medicine, MSRB II, RM 4570C, 1150 West Medical Center Drive, Ann Arbor, MI, 48109-5689, USA.
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Baker
authors.affiliation: Instituto de Investigaciones Biomédicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 10, C1121ABG, Buenos Aires, Argentina.
authors.forename: Mariela Moreno
authors.initials: MM
authors.lastname: Ayala
authors.affiliation: Department of Neurosurgery, The University of Michigan School of Medicine, MSRB II, RM 4570C, 1150 West Medical Center Drive, Ann Arbor, MI, 48109-5689, USA.|Department of Cell and Developmental Biology, The University of Michigan School of Medicine, MSRB II, RM 4570C, 1150 West Medical Center Drive, Ann Arbor, MI, 48109-5689, USA.
authors.forename: Marta
authors.initials: M
authors.lastname: Dzaman
authors.affiliation: Department of Neurosurgery, The University of Michigan School of Medicine, MSRB II, RM 4570C, 1150 West Medical Center Drive, Ann Arbor, MI, 48109-5689, USA.|Department of Cell and Developmental Biology, The University of Michigan School of Medicine, MSRB II, RM 4570C, 1150 West Medical Center Drive, Ann Arbor, MI, 48109-5689, USA.
authors.forename: Pedro R
authors.initials: PR
authors.lastname: Lowenstein
authors.affiliation: Department of Neurosurgery, The University of Michigan School of Medicine, MSRB II, RM 4570C, 1150 West Medical Center Drive, Ann Arbor, MI, 48109-5689, USA. mariacas@umich.edu.|Department of Cell and Developmental Biology, The University of Michigan School of Medicine, MSRB II, RM 4570C, 1150 West Medical Center Drive, Ann Arbor, MI, 48109-5689, USA. mariacas@umich.edu.
authors.forename: Maria G
authors.initials: MG
authors.lastname: Castro
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000628:therapy*; D045744:Cell Line, Tumor; D015316:Genetic Therapy; D005909:Glioblastoma / Q000628:therapy*; D006801:Humans; D051379:Mice; D009374:Neoplasms, Experimental; D051381:Rats
keywords: Adenoviral gene therapy; GBM models; Immunotherapy; T cell activation assays