title: Solvent-Enabled Radical Selectivities: Controlled Syntheses of Sulfoxides and Sulfides.
abstract: Controlling selectivity is of central importance to radical chemistry. However, the highly reactive and unstable radical intermediates make this task especially challenging. Herein, a strategy for taming radical redox reactions has been developed, in which solvent-bonding can alter the reactivity of the generated radical intermediates and thereby drastically alter the reaction selectivity at room temperature. Various β-oxy sulfoxides and β-hydroxy sulfides can be facilely obtained, some of which are difficult to synthesize by existing methods. Notably, neither a metal catalyst nor any further additives are necessary in these processes.
authors.affiliation: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P.R., China.
authors.forename: Huamin
authors.initials: H
authors.lastname: Wang
authors.affiliation: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P.R., China.
authors.forename: Qingquan
authors.initials: Q
authors.lastname: Lu
authors.affiliation: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P.R., China.
authors.forename: Chaohang
authors.initials: C
authors.lastname: Qian
authors.affiliation: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P.R., China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P.R., China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P.R., China.
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.affiliation: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, P.R., China. aiwenlei@whu.edu.cn.|National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, 330022, Jiangxi, P.R., China. aiwenlei@whu.edu.cn.
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei
keywords: dioxygen activation; metal-free; oxygenation; radical coupling; switchable selectivity