title: In Vivo Mapping of Cortical Columnar Networks in the Monkey with Focal Electrical and Optical Stimulation.
abstract: There are currently largescale efforts to understand the brain as a connection machine. However, there has been little emphasis on understanding connection patterns between functionally specific cortical columns. Here, we review development and application of focal electrical and optical stimulation methods combined with optical imaging and fMRI mapping in the non-human primate. These new approaches, when applied systematically on a large scale, will elucidate functionally specific intra-areal and inter-areal network connection patterns. Such functionally specific network data can provide accurate views of brain network topology.
authors.affiliation: Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University Hangzhou, China.
authors.forename: Anna Wang
authors.initials: AW
authors.lastname: Roe
authors.affiliation: Department of Psychology, Vanderbilt University, Nashville TN, USA.
authors.forename: Mykyta M
authors.initials: MM
authors.lastname: Chernov
authors.affiliation: Department of Psychology, Vanderbilt University, Nashville TN, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Friedman
authors.affiliation: Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University Hangzhou, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
keywords: cortical column; fMRI; infrared neural stimulation; microstimulation; monkey; optical imaging; optical stimulation; optogenetics