title: GILZ as a Mediator of the Anti-Inflammatory Effects of Glucocorticoids.
abstract: Glucocorticoid-induced leucine zipper (GILZ) is a dexamethasone-inducible gene that mediates glucocorticoid (GC) actions in a variety of cell types, including many cells of immune system. In particular, GILZ can control T cell activities, such as activation and differentiation, mainly through its ability to homo- and hetero-dimerize with partner proteins, such as NF-κB, Ras, and C/EBP. These protein-protein interactions control the regulation of pro-inflammatory target genes. A number of in vitro and in vivo studies using mouse models of inflammatory diseases demonstrate an anti-inflammatory role for GILZ. Here, authors summarize the studies that make GILZ eligible as an anti-inflammatory protein through which GCs can act. These findings permit the future development of pharmacological tools that mimic the therapeutic effects of GCs while avoiding the detrimental ones.
authors.affiliation: Section of Pharmacology, Department of Medicine, University of Perugia , Perugia , Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Ronchetti
authors.affiliation: Section of Pharmacology, Department of Medicine, University of Perugia , Perugia , Italy.
authors.forename: Graziella
authors.initials: G
authors.lastname: Migliorati
authors.affiliation: Section of Pharmacology, Department of Medicine, University of Perugia , Perugia , Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Riccardi
keywords: GILZ; glucocorticoids; immune cells; inflammation; transcription factor