title: Monitoring patients on chronic treatment with antidepressants between 2003 and 2011: analysis of factors associated with compliance.
abstract: BACKGROUND
  Clinical practice guidelines consider the use of antidepressants as one of the standard treatments for anxiety disorders, due to the significant improvements obtained in quality of life and functional disability. In addition, in patients who have not achieved a favorable response after 3 months of psychotherapy, antidepressants are recommended as part of a combined treatment approach. This combination with psychotropic drugs and psychotherapy appears to be indicated from baseline in patients with moderate, severe or recurrent depression. In the last decade, antidepressant prescription rates in general practice have increased between 4 and 10 times. Depression presents high rates of relapse and recurrence. Treatment is often interrupted prematurely, leading to increases in both relapse rates and health care costs. Few studies have analysed the chronic use of antidepressant drugs and long-term adherence.
  
  
  OBJECTIVE
  To evaluate compliance with antidepressant treatment between 2003 and 2011 and to explore the associated factors.
  
  
  METHODS
  Retrospective cohort study of antidepressant dispensing.
  
  
  METHODS
  Health Region of Lleida between 2003 and 2011.
  
  
  METHODS
  Patients with chronic prescription of antidepressants (ATC code NO6A) during 2003 were followed up until December 2011. The sample comprised 3684 subjects.
  
  
  METHODS
  The compliance rate was calculated on the basis of the number of units withdrawn from the pharmacy and the theoretical number of units required according to the scheduled duration of treatment: compliance was defined in cases with scores greater than or equal to 80%.
  
  
  RESULTS
  12.5% of patients received chronic antidepressant treatment for at least 4 years. Mean age was 54 years, and 73.2% of patients were female. Almost a third (32.4%) presented anxiety disorders and 26.5% mood disorders. The overall compliance rate was 22% (28% in patients with depression, and 21% in patients with anxiety). According to gender, compliance rates were 21.4% for males and 22.4% for females. Compliance was more likely in patients with polypharmacy.
  
  
  CONCLUSIONS
  One in 4 patients complied with treatment. Factors associated with better compliance were polypharmacy and diagnosis of depressive or mixed anxiety-depressive disorder.
authors.affiliation: Universidad de Lleida- IRB-Lleida, Lleida, Spain. cserna.lleida.ics@gencat.cat.|Centre d'Atenció Primària Eixample, Institut Català de la Salut, Lleida, Spain. cserna.lleida.ics@gencat.cat.
authors.forename: M Catalina
authors.initials: MC
authors.lastname: Serna
authors.affiliation: Unitat de Suport a la Recerca Lleida-Pirineus, Àmbit Atenció Primària Lleida, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Rambla Ferran, 44, 3ª planta, 25007, Lleida, Spain. jreal.lleida.ics@gencat.cat.|Facultat de Medicina i Ciències de la Salut, Universitat Intenacional de Catalunya, Sant Cugat, Barcelona, Spain. jreal.lleida.ics@gencat.cat.
authors.forename: Jordi
authors.initials: J
authors.lastname: Real
authors.affiliation: Unitat de Suport a la Recerca Lleida-Pirineus, Àmbit Atenció Primària Lleida, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Rambla Ferran, 44, 3ª planta, 25007, Lleida, Spain. icruz.lleida.ics@gencat.cat.|Centre d'Atenció Primària Primer de Maig, Institut Català de la Salut, Lleida, Spain. icruz.lleida.ics@gencat.cat.
authors.forename: Inés
authors.initials: I
authors.lastname: Cruz
authors.affiliation: Servei Català de la Salud, Lleida, Spain. lgalvan@catsalut.cat.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Galván
authors.affiliation: Centre d'Atenció Primària Consell de Cent, Institut Català de la Salut, Barcelona, Spain. emartingr.bcn.ics@gencat.cat.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Martin
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy*; D002908:Chronic Disease; D015331:Cohort Studies; D003863:Depression / Q000188:drug therapy*; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D017048:Health Care Costs; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D019338:Polypharmacy; D055553:Prescription Drugs; D011788:Quality of Life; D012189:Retrospective Studies; D012737:Sex Factors
chemical_list: D000928:Antidepressive Agents; D055553:Prescription Drugs