title: Reduced Maternal Erythrocyte Long Chain Polyunsaturated Fatty Acids Exist in Early Pregnancy in Preeclampsia.
abstract: The present prospective study examines proportions of maternal erythrocyte fatty acids across gestation and their association with cord erythrocyte fatty acids in normotensive control (NC) and preeclamptic pregnancies. We hypothesize that maternal fatty acid status in early pregnancy influences fetal fatty acid stores in preeclampsia. 137 NC women and 58 women with preeclampsia were included in this study. Maternal blood was collected at 3 time points during pregnancy (16-20th weeks, 26-30th weeks and at delivery). Cord blood was collected at delivery. Fatty acids were analyzed using gas chromatography. The proportions of maternal erythrocyte α-linolenic acid, docosahexaenoic acid, nervonic acid, and monounsaturated fatty acids (MUFA) (p < 0.05 for all) were lower while total n-6 fatty acids were higher (p < 0.05) at 16-20th weeks of gestation in preeclampsia as compared with NC. Cord 18:3n-3, 22:6n-3, 24:1n-9, MUFA, and total n-3 fatty acids (p < 0.05 for all) were also lower in preeclampsia as compared with NC. A positive association was observed between maternal erythrocyte 22:6n-3 and 24:1n-9 at 16-20th weeks with the same fatty acids in cord erythrocytes (p < 0.05 for both) in preeclampsia. Our study for the first time indicates alteration in maternal erythrocyte fatty acids at 16th weeks of gestation which is further reflected in cord erythrocytes at delivery in preeclampsia.
authors.affiliation: Department of Nutritional Medicine, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth Deemed University, Pune Satara Road, Pune, 411043, India.
authors.forename: Nisha S
authors.initials: NS
authors.lastname: Wadhwani
authors.affiliation: Department of Nutritional Medicine, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth Deemed University, Pune Satara Road, Pune, 411043, India.
authors.forename: Ankita S
authors.initials: AS
authors.lastname: Narang
authors.affiliation: Department of Obstetrics and Gynaecology, Bharati Medical College and Hospital, Bharati Vidyapeeth Deemed University, Pune, 411043, India.
authors.forename: Savita S
authors.initials: SS
authors.lastname: Mehendale
authors.affiliation: Department of Obstetrics and Gynaecology, Bharati Medical College and Hospital, Bharati Vidyapeeth Deemed University, Pune, 411043, India.
authors.forename: Girija N
authors.initials: GN
authors.lastname: Wagh
authors.affiliation: Gupte Hospital and Research Centre, Pune, 411004, India.
authors.forename: Sanjay A
authors.initials: SA
authors.lastname: Gupte
authors.affiliation: Department of Nutritional Medicine, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth Deemed University, Pune Satara Road, Pune, 411043, India. srjoshi62@gmail.com.
authors.forename: Sadhana R
authors.initials: SR
authors.lastname: Joshi
mesh_terms: D004912:Erythrocytes / Q000737:chemistry* / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000378:metabolism*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000378:metabolism*; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D005231:Fatty Acids, Unsaturated
keywords: Docosahexaenoic acid; Fatty acid analysis; Fatty acids; n-3 Fatty acids