title: A Controlled, Randomized Clinical Study on the Impact of Treatment on Antral Mucociliary Clearance: Uncinectomy Versus Balloon Sinuplasty.
abstract: OBJECTIVE
  To find out the effect of minimal invasive sinus surgery and balloon sinuplasty on mucociliary clearance and compare different methods of measuring mucociliary clearance.
  
  
  METHODS
  Twenty-nine patients with chronic rhinosinusitis were randomized in 2 operative groups (uncinectomy or balloon sinuplasty). Before and 6 months after the treatment, patients filled out a quality of life questionnaire (Sino Nasal Outcome Test-22 [SNOT-22]), and mucociliary clearance was measured with endoscope and gamma camera after 0.03 ml of saccharine, methylene-blue dye, and human albumin labeled with Tc99m was introduced to the bottom of maxillary sinuses.
  
  
  RESULTS
  In uncinectomy group, SNOT-22 score decreased, but treatment had no effect on mucociliary clearance. Based on saccharine test, smoking was associated with worse mucociliary clearance (r = 0.618, P < .05). Methylene blue test results associated with saccharine test (r = 0.434, P < .05) and Tc99m-labeled tracer technique (r = 0.261, P = .039) separately.
  
  
  CONCLUSIONS
  Treatment positively affects patients' quality of life; however, it has no effect on mucociliary clearance. There was a statistically significant correlation between the Tc99m-labeled tracer technique and the methylene blue technique. The saccharine technique was even less accurate, but it can be useful in clinical practice because it is a quick, easy, and safe technique.
authors.affiliation: Department of Otorhinolaryngology, Tampere University and Tampere University Hospital, Tampere, Finland arbizaki@gmail.com.
authors.forename: Argyro J
authors.initials: AJ
authors.lastname: Bizaki
authors.affiliation: Department of Otorhinolaryngology, Tampere University and Tampere University Hospital, Tampere, Finland.
authors.forename: Jura
authors.initials: J
authors.lastname: Numminen
authors.affiliation: Department of Otorhinolaryngology, Tampere University and Tampere University Hospital, Tampere, Finland.
authors.forename: Rami
authors.initials: R
authors.lastname: Taulu
authors.affiliation: Department of Otorhinolaryngology, Tampere University and Tampere University Hospital, Tampere, Finland.
authors.forename: Markus
authors.initials: M
authors.lastname: Rautiainen
mesh_terms: D000328:Adult; D002908:Chronic Disease; D004724:Endoscopy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009079:Mucociliary Clearance / Q000502:physiology*; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D010256:Paranasal Sinuses / Q000601:surgery*; D011788:Quality of Life; D019651:Plastic Surgery Procedures / Q000379:methods*; D012220:Rhinitis / Q000378:metabolism / Q000601:surgery*; D012852:Sinusitis / Q000378:metabolism / Q000601:surgery*; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome
keywords: Mucociliary clearance; endoscopic sinus surgery; endoscopic surgery; pansinusitis; sinusitis