title: [The diversity of leptin].
abstract: The role of leptin in regulation of energy homeostasis is well established, yet both the diagnostic as well as the therapeutic relevance of leptin in diet-induced obesity remains unresolved. Nevertheless, in the last few years, the substantial impact of leptin substitution in selected forms of monogenic obesity has advanced our knowledge about the neuroendocrine network of body weight regulation. Moreover, leptin seems to play a crucial role in intestinal nutrient reabsorption, regulation of blood pressure, fertility, inflammation and autoimmune diseases. A better understanding of these processes could possibly provide novel diagnostic and therapeutic options in the future.
authors.affiliation: Medizinische Klinik für Endokrinologie, Diabetes und Ernährungsmedizin, Charité - Universitätsmedizin Berlin.
authors.forename: Knut
authors.initials: K
authors.lastname: Mai
mesh_terms: D001327:Autoimmune Diseases / Q000188:drug therapy / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001823:Body Composition / Q000187:drug effects / Q000502:physiology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology*; D005298:Fertility / Q000187:drug effects / Q000502:physiology; D006706:Homeostasis / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology; D020738:Leptin / Q000502:physiology* / Q000627:therapeutic use*; D009765:Obesity / Q000188:drug therapy* / Q000503:physiopathology*
chemical_list: D020738:Leptin