title: Infection and the Perils of B-cell Activation.
abstract: Recent studies have linked aberrant B-cell activation in the context of aberrant immune responses to infectious pathogens to malignant transformation and development of leukemia and lymphoma. A new study in this issue demonstrates that common infections can be drivers of clonal evolution of premalignant B-cell precursors toward childhood leukemia.
authors.affiliation: Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.
authors.forename: Mel
authors.initials: M
authors.lastname: Greaves
authors.affiliation: Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California. markus.muschen@ucsf.edu.
authors.forename: Markus
authors.initials: M
authors.lastname: Müschen
mesh_terms: D001402:B-Lymphocytes; D002471:Cell Transformation, Neoplastic; D060965:Clonal Evolution; D006801:Humans; D007938:Leukemia; D008213:Lymphocyte Activation