title: IL-17 producing innate lymphoid cells 3 (ILC3) but not Th17 cells might be the potential danger factor for preeclampsia and other pregnancy associated diseases.
abstract: In pregnancy, the immunologic system plays an important role that ensures normal pregnancy development and can as well promote the development of complications. Pregnancy success appears to rely on a discrete balance between the Th cytokines, which are involved in fetal growth and development. Preeclampsia and gestational diabetes are known complications associated with pregnancy. However, the source of the increased IL-17 cytokine in preeclampsia and other pregnancy associated diseases still remains unclear amidst numerous inconsistencies. The recent identification of innate lymphoid cells (ILC) has raised more doubts about the sources of most of the Th associated cytokines. We investigated the source of peripheral IL-17 levels in preeclamptic, gestational diabetics and chronic diabetics compared to healthy pregnancy subjects. To evaluate the source of the increased IL-17 cytokine among preeclampsia, chronic diabetic and gestational diabetic patients we investigated the proportion of Th17 cell populations in peripheral blood mononuclear cells using flow cytometry as well as analyzing levels of IFN-γ, IL-17, IL-1β and HMGB1. This study found that the Th17 cell populations in peripheral blood of preeclamptic, gestational nor chronic diabetes during pregnancy did not correlate with the increased IL-17. We report that the increased IL-17 levels observed in patients with preeclampsia, gestational diabetes and chronic diabetes are associated with innate lymphoid cells 3 (ILC3) and may pose threats to the fetus if disregulated.
authors.affiliation: Department of Immunology, School of Medicine, Jiangsu University Zhenjiang 212013, PR China ; Department of Biomedical and Forensic Sciences, School of Biological Sciences, University of Cape Coast Ghana.
authors.forename: Prince A
authors.initials: PA
authors.lastname: Barnie
authors.affiliation: Department of Laboratory Medicine, The Fourth Affiliated Hospital of Jiangsu University Zhenjiang 212001, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Laboratory Medicine, The Fourth Affiliated Hospital of Jiangsu University Zhenjiang 212001, PR China.
authors.forename: Yueqin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Immunology, School of Medicine, Jiangsu University Zhenjiang 212013, PR China.
authors.forename: Huaxi
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Immunology, School of Medicine, Jiangsu University Zhenjiang 212013, PR China ; Department of Laboratory Medicine, The Fourth Affiliated Hospital of Jiangsu University Zhenjiang 212001, PR China.
authors.forename: Zhaoliang
authors.initials: Z
authors.lastname: Su
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D024243:HMGB1 Protein / Q000097:blood / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000097:blood / Q000276:immunology; D020381:Interleukin-17 / Q000097:blood / Q000276:immunology*; D053583:Interleukin-1beta / Q000097:blood / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D012307:Risk Factors; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015415:Biomarkers; D024243:HMGB1 Protein; C585491:HMGB1 protein, human; C573415:IFNG protein, human; C508585:IL1B protein, human; D020381:Interleukin-17; D053583:Interleukin-1beta; D007371:Interferon-gamma
keywords: Gestational diabetes; Th17 cells; innate lymphoid cells; preeclampsia