title: Modifying Yeast Tolerance to Inhibitory Conditions of Ethanol Production Processes.
abstract: Saccharomyces cerevisiae strains having a broad range of substrate utilization, rapid substrate consumption, and conversion to ethanol, as well as good tolerance to inhibitory conditions are ideal for cost-competitive ethanol production from lignocellulose. A major drawback to directly design S. cerevisiae tolerance to inhibitory conditions of lignocellulosic ethanol production processes is the lack of knowledge about basic aspects of its cellular signaling network in response to stress. Here, we highlight the inhibitory conditions found in ethanol production processes, the targeted cellular functions, the key contributions of integrated -omics analysis to reveal cellular stress responses according to these inhibitors, and current status on design-based engineering of tolerant and efficient S. cerevisiae strains for ethanol production from lignocellulose.
authors.affiliation: Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos , Cuernavaca , Mexico.
authors.forename: Luis
authors.initials: L
authors.lastname: Caspeta
authors.affiliation: Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos , Cuernavaca , Mexico.
authors.forename: Tania
authors.initials: T
authors.lastname: Castillo
authors.affiliation: Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology , Gothenburg , Sweden ; Department of Biology and Biological Engineering, Chalmers University of Technology , Gothenburg , Sweden ; Novo Nordisk Foundation Center for Biosustainability , Hørsholm , Denmark.
authors.forename: Jens
authors.initials: J
authors.lastname: Nielsen
keywords: cellular stress response; design-based engineering; ethanol production process; inhibitory environment; integrated -omics analysis; stress tolerance; yeast