title: An Optimized Combination of Ginger and Peony Root Effectively Inhibits Amyloid-β Accumulation and Amyloid-β-Mediated Pathology in AβPP/PS1 Double-Transgenic Mice.
abstract: The progressive aggregation of amyloid-β protein (Aβ) into senile plaques is a major pathological factor of Alzheimer's disease (AD) and is believed to result in memory impairment. We aimed to investigate the effect of an optimized combination of ginger and peony root (OCGP), a standardized herbal mixture of ginger and peony root, on Aβ accumulation and memory impairment in amyloid-β protein precursor (AβPP)/presenilin 1 (PS1) double-transgenic mice. In an in vitro thioflavin T fluorescence assay, 100 μg/ml OCGP inhibited Aβ accumulation to the same extent as did 10 μM curcumin. Furthermore, AβPP/PS1 double-transgenic mice treated with OCGP (50 or 100 mg/kg/day given orally for 14 weeks) exhibited reduced Aβ plaque accumulation in the hippocampus and lower levels of glial fibrillary acid protein and cyclooxygease-2 expression compared with vehicle-treated controls. These results suggest that OCGP may prevent memory impairment in AD by inhibiting Aβ accumulation and inflammation in the brain.
authors.affiliation: Department of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.
authors.forename: Soonmin
authors.initials: S
authors.lastname: Lim
authors.affiliation: Department of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.
authors.forename: Jin Gyu
authors.initials: JG
authors.lastname: Choi
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University, Daejeon, Republic of Korea.
authors.forename: Minho
authors.initials: M
authors.lastname: Moon
authors.affiliation: Department of Oriental Pharmaceutical Science, College of Pharmacy and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.
authors.forename: Hyo Geun
authors.initials: HG
authors.lastname: Kim
authors.affiliation: Department of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.
authors.forename: Wonil
authors.initials: W
authors.lastname: Lee
authors.affiliation: CJ Healthcare R&D center, Majang-myeon, Icheon, Gyeonggi, Republic of Korea.
authors.forename: Hyoung-Rok
authors.initials: HR
authors.lastname: Bak
authors.affiliation: CJ Healthcare R&D center, Majang-myeon, Icheon, Gyeonggi, Republic of Korea.
authors.forename: Hachang
authors.initials: H
authors.lastname: Sung
authors.affiliation: CJ Healthcare R&D center, Majang-myeon, Icheon, Gyeonggi, Republic of Korea.
authors.forename: Chi Hye
authors.initials: CH
authors.lastname: Park
authors.affiliation: Gachon Institute of Pharmaceutical Science, Gachon University, Yeonsu-gu, Incheon, Republic of Korea.
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Department of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.|Department of Oriental Pharmaceutical Science, College of Pharmacy and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.
authors.forename: Myung Sook
authors.initials: MS
authors.lastname: Oh
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000704:Analysis of Variance; D000818:Animals; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D020939:Zingiber officinale / Q000737:chemistry; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D029596:Paeonia / Q000737:chemistry; D008517:Phytotherapy / Q000379:methods*; D028321:Plant Preparations / Q000627:therapeutic use; D058225:Plaque, Amyloid / Q000188:drug therapy / Q000473:pathology*; D053764:Presenilin-1 / Q000235:genetics
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D005904:Glial Fibrillary Acidic Protein; D028321:Plant Preparations; D053764:Presenilin-1; C077623:Ptgs2 protein, mouse; D051546:Cyclooxygenase 2
keywords: Aβ accumulation; AβPP/PS1 double-transgenic mice; neuroinflammation; optimized combination of ginger and peony root