title: microRNA-506 regulates proliferation, migration and invasion in hepatocellular carcinoma by targeting F-spondin 1 (SPON1).
abstract: Our previous study indicates microRNA-506 (miR-506) is downregulated in hepatocellular carcinoma (HCC). In the current study, we investigate the effects of miR-506 on proliferation, migration and invasion in HCC. We report that enforced expression of miR-506 inhibits proliferation, migration and invasion in vitro, and suppresses tumor growth in vivo. Conversely, suppression of miR-506 exhibits promoting effects on proliferation, migration and invasion in vitro, and on tumor growth in vivo. In addition, miR-506 binds to the 3'UTR of F-spondin 1(SPON1), and enforced expression of miR-506 decreases accumulation of SPON1. Moreover, enforced expression of SPON1 and suppression of SPON1 alleviates effects of miR-506 mimics and inhibitors on proliferation, migration and invasion in vitro, respectively. In conclusion, microRNA-506 regulates proliferation, migration and invasion in HCC by targeting SPON1.
authors.affiliation: Department of Hepatobiliary Surgery, The Affiliated Hospital of Guangdong Medical College 524001 Zhanjiang, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Dai
authors.affiliation: Clinical Research Center, The Affiliated Hospital of Guangdong Medical College 524001 Zhanjiang, China.
authors.forename: Hai-Li
authors.initials: HL
authors.lastname: Huang
authors.affiliation: Department of Hepatobiliary Surgery, The Affiliated Hospital of Guangdong Medical College 524001 Zhanjiang, China.
authors.forename: Min
authors.initials: M
authors.lastname: Hu
authors.affiliation: Clinical Research Center, The Affiliated Hospital of Guangdong Medical College 524001 Zhanjiang, China.
authors.forename: Si-Jie
authors.initials: SJ
authors.lastname: Wang
authors.affiliation: Clinical Research Center, The Affiliated Hospital of Guangdong Medical College 524001 Zhanjiang, China.
authors.forename: Hui-Juan
authors.initials: HJ
authors.lastname: He
authors.affiliation: Department of Hepatobiliary Surgery, The Affiliated Hospital of Guangdong Medical College 524001 Zhanjiang, China.
authors.forename: Nian-Pin
authors.initials: NP
authors.lastname: Chen
authors.affiliation: Department of Hepatobiliary Surgery, The Affiliated Hospital of Guangdong Medical College 524001 Zhanjiang, China.
authors.forename: Ming-Yi
authors.initials: MY
authors.lastname: Li
keywords: SPON1; hepatocellular carcinoma; microRNA-506; migration and invasion; proliferation