title: Differentiating brain metastases from different pathological types of lung cancers using texture analysis of T1 postcontrast MR.
abstract: The goal of this study was to investigate the feasibility of differentiating brain metastases from different types of lung cancers using texture analysis (TA) of T1 postcontrast MR images.
  
  
  
  TA was performed, and four subset textures were extracted and calculated separately. The capability of each texture to classify the different types of lung carcinoma was investigated using the Kruskal-Wallis test and receiver operating characteristic analysis. K-nearest neighbor (KNN) classifier model and back-propagation artificial neural network (BP-ANN) classifier model were used to build models and improve the predictive ability of TA.
  
  
  
  Texture-based lesion classification was highly specific in differentiating brain metastases originated from different types of lung cancers, with misclassification rates of 3.1%, 4.3%, 5.8%, and 8.1%, respectively, for small cell lung carcinoma, squamous cell carcinoma, adenocarcinoma, and large cell lung carcinoma. The BP-ANN model had a better predictive ability than the KNN model. No texture feature could distinguish between all four types of lung cancer.
  
  
  
  TA may predict the differences among various pathological types of lung cancer with brain metastases. The texture parameters, which reflect the tumor histopathology structure, may serve as an adjunct tool for clinically accurate diagnoses and deserves further investigation. Magn Reson Med 76:1410-1419, 2016. © 2015 International Society for Magnetic Resonance in Medicine.
authors.affiliation: Laboratory of Image Science and Technology, Southeast University, Nanjing, PR China.|Department of Radiation Oncology (Chest Section), Key Laboratory of Radiation Oncology of Shandong Province, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, PR China.
authors.forename: Zhenjiang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology (Chest Section), Key Laboratory of Radiation Oncology of Shandong Province, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, PR China.|Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Mao
authors.affiliation: Department of Radiation Oncology (Chest Section), Key Laboratory of Radiation Oncology of Shandong Province, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, PR China.
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Li
authors.affiliation: Laboratory of Image Science and Technology, Southeast University, Nanjing, PR China.
authors.forename: Gang
authors.initials: G
authors.lastname: Yu
authors.affiliation: College of Physics and Electronics, Shandong Normal University, Jinan, PR China.
authors.forename: Honglin
authors.initials: H
authors.lastname: Wan
authors.affiliation: Laboratory of Image Science and Technology, Southeast University, Nanjing, PR China. baoshli1963@163.com.|Department of Radiation Oncology (Chest Section), Key Laboratory of Radiation Oncology of Shandong Province, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, PR China. baoshli1963@163.com.
authors.forename: Baosheng
authors.initials: B
authors.lastname: Li
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary*; D003287:Contrast Media; D003937:Diagnosis, Differential; D016002:Discriminant Analysis; D005240:Feasibility Studies; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media
keywords: brain metastases; lung cancer; magnetic resonance imaging; texture analysis