title: Functional role of inorganic trace elements in angiogenesis part III: (Ti, Li, Ce, As, Hg, Va, Nb and Pb).
abstract: Many essential elements exist in nature with significant influence on human health. Angiogenesis is vital in developmental, repair, and regenerative processes, and its aberrant regulation contributes to pathogenesis of many diseases including cancer. Thus, it is of great importance to explore the role of these elements in such a vital process. This is third in a series of reviews that serve as an overview of the role of inorganic elements in regulation of angiogenesis and vascular function. Here we will review the roles of titanium, lithium, cerium, arsenic, mercury, vanadium, niobium, and lead in these processes. The roles of other inorganic elements in angiogenesis were discussed in part I (N, Fe, Se, P, Au, and Ca) and part II (Cr, Si, Zn, Cu, and S) of these series. The methods of exposure, structure, mechanisms, and potential activities of these elements are briefly discussed. An electronic search was performed on the role of these elements in angiogenesis from January 2005 to April 2014. These elements can promote and/or inhibit angiogenesis through different mechanisms. The anti-angiogenic effect of titanium dioxide nanoparticles comes from the inhibition of angiogenic processes, and not from its toxicity. Lithium affects vasculogenesis but not angiogenesis. Nanoceria treatment inhibited tumor growth by inhibiting angiogenesis. Vanadium treatment inhibited cell proliferation and induced cytotoxic effects through interactions with DNA. The negative impact of mercury on endothelial cell migration and tube formation activities was dose and time dependent. Lead induced IL-8 production, which is known to promote tumor angiogenesis. Thus, understanding the impact of these elements on angiogenesis will help in development of new modalities to modulate angiogenesis under various conditions.
authors.affiliation: Departments of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Biomedical Engineering, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Angiogenesis and Regenerative Group, Dr. H. Afsar Lajevardi Research Cluster, Shiraz, Iran. Electronic address: Saghiri@wisc.edu.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Saghiri
authors.affiliation: Angiogenesis and Regenerative Group, Dr. H. Afsar Lajevardi Research Cluster, Shiraz, Iran.
authors.forename: Jafar
authors.initials: J
authors.lastname: Orangi
authors.affiliation: Angiogenesis and Regenerative Group, Dr. H. Afsar Lajevardi Research Cluster, Shiraz, Iran.
authors.forename: Armen
authors.initials: A
authors.lastname: Asatourian
authors.affiliation: Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Sorenson
authors.affiliation: Departments of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Biomedical Engineering, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Nader
authors.initials: N
authors.lastname: Sheibani
mesh_terms: D001151:Arsenic / Q000494:pharmacology; D002563:Cerium / Q000494:pharmacology; D006801:Humans; D007854:Lead / Q000494:pharmacology; D008094:Lithium / Q000494:pharmacology; D008628:Mercury / Q000494:pharmacology; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D009556:Niobium / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D014025:Titanium / Q000494:pharmacology; D014131:Trace Elements / Q000494:pharmacology*; D014639:Vanadium / Q000494:pharmacology
chemical_list: D017382:Reactive Oxygen Species; D014131:Trace Elements; D014639:Vanadium; D009556:Niobium; C009495:titanium dioxide; D007854:Lead; D002563:Cerium; D008094:Lithium; D014025:Titanium; D008628:Mercury; D001151:Arsenic
keywords: Angiogenesis; Endothelial cells; Inorganic elements