title: Role of Endoscopy in Diagnosis and Management of Pediatric Eosinophilic Esophagitis.
abstract: Eosinophilic esophagitis (EoE) is a chronic allergic (immune-mediated) disease that leads to esophageal dysfunction and feeding disorders in children. Foods, and possibly environmental triggers, cause an inflammatory response in the esophagus, leading to esophageal inflammation, eosinophilic infiltration, and esophageal dysmotility, which may progress to dysphagia, food impaction, and esophageal stricture. Endoscopy with biopsy and histologic evaluation is currently the only method to diagnose EoE. Once diagnosed with EoE, children undergo follow-up endoscopy after therapy initiation and adjustments to ensure remission. Furthermore, children with food impactions or strictures may require endoscopic intervention such as foreign body removal and/or esophageal dilation.
authors.affiliation: Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Amanda B
authors.initials: AB
authors.lastname: Muir
authors.affiliation: Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Jamie
authors.initials: J
authors.lastname: Merves
authors.affiliation: Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: Liacouras@email.chop.edu.
authors.forename: Chris A
authors.initials: CA
authors.lastname: Liacouras
mesh_terms: D001706:Biopsy; D002648:Child; D003680:Deglutition Disorders / Q000209:etiology / Q000601:surgery; D004106:Dilatation; D016145:Endoscopy, Digestive System / Q000379:methods*; D057765:Eosinophilic Esophagitis / Q000150:complications / Q000175:diagnosis* / Q000601:surgery*; D004940:Esophageal Stenosis / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D004947:Esophagus / Q000473:pathology / Q000601:surgery; D006801:Humans
keywords: Dilation; Dysphagia; Eosinophilic esophagitis; Food allergy; Food impaction