title: Association of Apolipoprotein A1 Gene Polymorphisms with Serum Lipid Spectrum in Adolescents in East Siberia.
abstract: We studied the incidence of genotypes of polymorphic alleles (-75)G>A and (+83)C>T of apolipoprotein A1 gene in healthy Russian adolescents, residents of East Siberia. Genotyping was carried out by PCR with subsequent restriction fragment length polymorphism analysis. The incidence of allele (-75)A was 22.5%, of allele (+83)T - 7.3%. Association of allele (-75) A with high blood cholesterol level was revealed.
authors.affiliation: Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia. tbairova@mail.ru.
authors.forename: T A
authors.initials: TA
authors.lastname: Bairova
authors.affiliation: Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Kalyuzhnaya
authors.affiliation: Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Dolgikh
authors.affiliation: Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Trukhin
authors.affiliation: Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Pervushina
authors.affiliation: Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Darenskaya
authors.affiliation: Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Kolesnikova
authors.affiliation: Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia.
authors.forename: S I
authors.initials: SI
authors.lastname: Kolesnikov
mesh_terms: D000293:Adolescent; D000483:Alleles; D016632:Apolipoprotein A-I / Q000235:genetics*; D002648:Child; D002784:Cholesterol / Q000097:blood; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D012800:Siberia
chemical_list: D016632:Apolipoprotein A-I; D008055:Lipids; D002784:Cholesterol
keywords: Russians; adolescents; apolipoprotein A1; genotype; lipids