title: Relationship between the HLA-G 14 bp insertion/deletion polymorphism and susceptibility to autoimmune disease: a meta-analysis.
abstract: Numerous studies have investigated the potential relationship between the human leukocyte antigen (HLA)-G 14-bp insertion/deletion (INS/DEL) polymorphisms and autoimmune disease (AID). However, published results are inconclusive. Our aim was to determine whether the 14-bp INS/DEL polymorphism in the HLA-G gene contributes to the risk of AID. A systemic literature search of the PubMed and EMBASE databases was conducted to identify eligible studies investigating the association of the HLA-G 14-bp INS/DEL polymorphism with AID. Our analysis included 11 publications involving a total of 6462 individuals. Overall, no significant association between the HLA-G 14-bp INS/DEL polymorphism and AID was detected in any comparison model. Further subgroup analyses based on AID types and ethnicity also revealed no significant associations. Our results suggest that the HLA-G 14-bp INS/DEL polymorphism is unrelated to the development of AID. Further studies including larger sample sizes are warranted to confirm these results.
authors.affiliation: Kohwang Medical Research Institute and Department of Pharmacology, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: S K
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Jeong
authors.affiliation: Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: I J
authors.initials: IJ
authors.lastname: Kang
authors.affiliation: Kohwang Medical Research Institute and Department of Pharmacology, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Chung
authors.affiliation: Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: M K
authors.initials: MK
authors.lastname: Shin
authors.affiliation: Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea mhlee@khmc.or.kr.
authors.forename: M H
authors.initials: MH
authors.lastname: Lee
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D059951:HLA-G Antigens / Q000235:genetics*; D006801:Humans; D054643:INDEL Mutation; D016017:Odds Ratio; D011110:Polymorphism, Genetic
chemical_list: D059951:HLA-G Antigens