title: Antimalarial and insecticidal activities of newly synthesized derivatives of Benzimidazole.
abstract: The bioactive benzimidazole and corresponding substituted phenacyl halides has been synthesized (11) new derivatives out of three compounds 8, 10 and 11 were found to inhibit the Plasmodium falciparum moderately after 72 hours of incubation hence acting as antimalarial agents. While these derivatives were exhibited negligible insecticidal activity too when analyzed by impregnated filter paper method.
authors.affiliation: Department of Pharmaceutical Chemistry, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan.
authors.forename: Arfa
authors.initials: A
authors.lastname: Kamil
authors.affiliation: Department of Pharmaceutical Chemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Shamim
authors.initials: S
authors.lastname: Akhter
authors.affiliation: Department of Pharmacognosy, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan.
authors.forename: Maryam
authors.initials: M
authors.lastname: Ahmed
authors.affiliation: Department of Pharmacognosy, University of Karachi, Karachi, Pakistan.
authors.forename: Ghazala H
authors.initials: GH
authors.lastname: Rizwani
authors.affiliation: Department of Pharmaceutical Chemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Sohail
authors.initials: S
authors.lastname: Hassan
authors.affiliation: Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Sabahat
authors.initials: S
authors.lastname: Naeem
authors.affiliation: Department of Pharmaceutical Chemistry, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan.
authors.forename: Sarwat
authors.initials: S
authors.lastname: Jahan
authors.affiliation: Department of Pharmacognosy, University of Karachi, Karachi, Pakistan.
authors.forename: Raheela
authors.initials: R
authors.lastname: Khursheed
authors.affiliation: Department of Pharmacognosy, University of Karachi, Karachi, Pakistan.
authors.forename: Hina
authors.initials: H
authors.lastname: Zahid
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D007306:Insecticides / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D000962:Antimalarials; D001562:Benzimidazoles; D007306:Insecticides