title: Selenium bioaccessibility in stomach, small intestine and colon: Comparison between pure Se compounds, Se-enriched food crops and food supplements.
abstract: Selenium (Se) is an essential nutrient for humans as it plays an important role in glutathione peroxidase (GPx) activity. Moreover, it may reduce cancer risks. The objective of this work was to examine in vitro the bioaccessibility of Se in three different Se-enriched food supplements and two different Se-enriched food crops, with reference to two pure Se standards, and changes in its speciation during intestinal digestion. Selenate was found to be stable throughout the entire digestion, whereas incubation of selenomethionine resulted in the chemical and microbial production of minor metabolites. The bioaccessibility of Se in Se-enriched food supplements and food crops was found to be highest in the small intestine. Compared to SelenoPrecise and Se-ACE tablets, a yoghurt-based supplement exhibited a much lower Se bioaccessibility, possibly due to the presence of nano- or microparticles of elemental Se. Colon microbiota were found to primarily affect Se bioaccessibility in the colon environment, with the presence of inactivated microbiota resulting in a higher bioaccessibility. A higher potential of Se to reach the colon and become accessible in this phase may result in beneficial effects on the colon health.
authors.affiliation: Laboratory of Analytical Chemistry and Applied Ecochemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Gent, Belgium. Electronic address: srikanthlavu1@gmail.com.
authors.forename: Rama V Srikanth
authors.initials: RV
authors.lastname: Lavu
authors.affiliation: Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Gent, Belgium.
authors.forename: Tom
authors.initials: T
authors.lastname: Van De Wiele
authors.affiliation: Laboratory of Analytical Chemistry and Applied Ecochemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Gent, Belgium; Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Gent, Belgium.
authors.forename: Varalakshmi L
authors.initials: VL
authors.lastname: Pratti
authors.affiliation: Laboratory of Analytical Chemistry and Applied Ecochemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Gent, Belgium.
authors.forename: Filip
authors.initials: F
authors.lastname: Tack
authors.affiliation: Laboratory of Analytical Chemistry and Applied Ecochemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Gent, Belgium.
authors.forename: Gijs
authors.initials: G
authors.lastname: Du Laing
mesh_terms: D003106:Colon / Q000378:metabolism*; D018556:Crops, Agricultural / Q000737:chemistry / Q000378:metabolism; D019587:Dietary Supplements / Q000032:analysis*; D004063:Digestion; D005527:Food, Fortified / Q000032:analysis*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D007421:Intestine, Small / Q000378:metabolism*; D064586:Selenic Acid / Q000032:analysis / Q000378:metabolism; D018036:Selenium Compounds / Q000032:analysis / Q000378:metabolism*; D012645:Selenomethionine / Q000032:analysis / Q000378:metabolism
chemical_list: D018036:Selenium Compounds; D012645:Selenomethionine; D064586:Selenic Acid
keywords: Bioaccessibility; Colon; Digestion phase; Se-enriched; Selenate; Selenomethionine