title: Incidental diffuse low-grade gliomas: from early detection to preventive neuro-oncological surgery.
abstract: Although a large amount of data supports early surgical resection for symptomatic diffuse low-grade glioma, the therapeutic strategy is still a matter of debate regarding incidentally discovered diffuse low-grade glioma. Indeed, early and "preventive" surgery has recently been proposed in asymptomatic patients with silent diffuse low-grade glioma with better outcomes. The present review discusses the importance of an early diagnosis and of a preventive surgical treatment to improve the outcomes of incidental diffuse low-grade glioma and suggests the possible relevance of a tailored screening policy.
authors.affiliation: Department of Neurosurgery, Onofre Lopes University Hospital, Rio Grande do Norte Federal University, Natal, RN, Brazil.|Department of Neurosurgery, Sainte-Anne Hospital, Paris, France.|University Paris Descartes, Paris, France.
authors.forename: Guilherme Lucas de Oliveira
authors.initials: GL
authors.lastname: Lima
authors.affiliation: Department of Neurosurgery, Sainte-Anne Hospital, Paris, France.|University Paris Descartes, Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Zanello
authors.affiliation: Réseau d'Etude des Gliomes (REG), Groland, France.|Department of Neurosurgery, Lariboisiere Hospital, Paris, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Mandonnet
authors.affiliation: Réseau d'Etude des Gliomes (REG), Groland, France.|Department of Neuro-Oncology, Nancy Neurological Hospital, Nancy, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Taillandier
authors.affiliation: Department of Neurosurgery, Sainte-Anne Hospital, Paris, France. johanpallud@hotmail.com.|University Paris Descartes, Paris, France. johanpallud@hotmail.com.|Réseau d'Etude des Gliomes (REG), Groland, France. johanpallud@hotmail.com.|Histopathology and Animal Models, Institut Pasteur, Paris, France. johanpallud@hotmail.com.|Department of Neurosurgery, Hôpital Sainte-Anne, 1 Rue Cabanis, Cedex 14, 75674, Paris, France. johanpallud@hotmail.com.
authors.forename: Johan
authors.initials: J
authors.lastname: Pallud
authors.affiliation: Réseau d'Etude des Gliomes (REG), Groland, France.|Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34295, Montpellier, France.|Institute for Neuroscience of Montpellier, INSERM U1051, Team "Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors," Saint Eloi Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34091, Montpellier, France.
authors.forename: Hugues
authors.initials: H
authors.lastname: Duffau
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D042241:Early Diagnosis; D005910:Glioma / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D060787:Neoplasm Grading; D019635:Neurosurgical Procedures / Q000379:methods; D016896:Treatment Outcome
keywords: Diffuse low-grade glioma; Incidental discovery; Outcomes; Preventive surgery