title: Correlation between CYP4F2 gene rs2108622 polymorphism and susceptibility to ischemic stroke.
abstract: OBJECTIVE
  To conduct a meta-analysis for the correlation between cytochrome P450 4F2 (CYP4F2) rs2108622 (V433M) gene polymorphism and ischemic stroke.
  
  
  METHODS
  We retrieved the case-control studies on the correlation between CYP4F2 V433M polymorphism and ischemic stroke included in domestic and international databases before January 2015 and selected the best genetic model, using RevMan 5.2 software for meta-analysis. According to the heterogeneity test results of selected literature, the effect model of consolidated data was selected, and the combined OR and 95% CI were calculated.
  
  
  RESULTS
  A total of six documents were included. Recessive model (VM + MM vs. VV) was selected as the best genetic model. The combined results showed that: compared with wild-type VV, there are significant association between ischemic stroke and CYP4F2 polymorphism (OR merge = 1.37, 95% CI: 1.21~1.54, P < 0.001).
  
  
  CONCLUSIONS
  CYP4F2 V433M may be the susceptibility gene for ischemic stroke.
authors.affiliation: Urgent Care Center, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, Shandong, China.
authors.forename: Chong
authors.initials: C
authors.lastname: Meng
authors.affiliation: Department of Respiratory Healthcare Medicine, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, Shandong Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Qingdao Eighth People's Hospital Qingdao 266100, Shandong, China.
authors.forename: Wei-Ning
authors.initials: WN
authors.lastname: Ge
authors.affiliation: Department of Rehabilitation Medicine, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, Shandong Province, China.
authors.forename: Shao-Can
authors.initials: SC
authors.lastname: Tang
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, Shandong Province, China.
authors.forename: Guang-Ming
authors.initials: GM
authors.lastname: Xu
keywords: Ischemic stroke; cytochrome P450 4F2; gene polymorphism; meta-analysis; susceptibility