title: Squamous cell carcinoma of lung associated with osteoclast-like giant cells: report of a case.
abstract: Resently, we treated a 69-year-old patient with squamous cell carcinoma of lung with osteoclast-like giant cells which were similar with the giant cell tumor of bone. The clinical and pathological characteristics of this case were presented, and the literatures were reviewed. The tumor differed histologically from the pleomorphic carcinoma, which occurs most commonly in the lung and showed diverse pleomorphic manifestation with benign looking osteoclast-like multinucleated cells and bizarre giant cells. In addition, undifferentiated carcinoma with a sarcoma-like appearance containing small areas of papillary adenocarcinoma was evident in the tumor. Histological features and immunohistochemical staining could be helpful in differential diagnosis.
authors.affiliation: Department of Intensive Care Unit, Yishui Central Hospital Linyi 276400, China.
authors.forename: Lingchen
authors.initials: L
authors.lastname: Kong
authors.affiliation: Department of Intensive Care Unit, Yishui Central Hospital Linyi 276400, China.
authors.forename: Wenhong
authors.initials: W
authors.lastname: Peng
authors.affiliation: Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University Yantai 264000, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University Yantai 264000, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Image Center, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University Yantai 264000, China.
authors.forename: Peiyou
authors.initials: P
authors.lastname: Gong
authors.affiliation: Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University Yantai 264000, China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Yu
authors.affiliation: Department of Image Center, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University Yantai 264000, China.
authors.forename: Junxia
authors.initials: J
authors.lastname: Li
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D002454:Cell Differentiation; D059186:Chemoradiotherapy, Adjuvant; D003937:Diagnosis, Differential; D005870:Giant Cell Tumors / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D008297:Male; D010010:Osteoclasts / Q000737:chemistry / Q000473:pathology*; D011013:Pneumonectomy; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Lung; osteoclast-like giant cells; squamous cell carcinoma