title: Fatty acids, eicosanoids and PPAR gamma.
abstract: Peroxisome proliferator-activated receptor γ (PPARγ) belongs to the family of nuclear nuclear receptors and is mainly expressed in adipose tissue, hematopoietic cells and the large intestine. Contrary to other nuclear receptors that mainly bind a single specific ligand, there are numerous natural PPARγ ligands, in particular fatty acids or their derivatives called eicosanoids. PPARγ have pleiotropic functions: (i) glucose and lipid metabolism regulation, (ii) anti-inflammatory properties, (iii) oxidative stress inhibition, (iv) improvement of endothelial function. Its role has been mainly studied by the use synthetic agonists. In this review, we will focus on the effects of PPARγ mediated through fatty acids and how these have beneficial health properties.
authors.affiliation: INSERM Unit UMR1073, Rouen University and Rouen University hospital, 22, boulevard Gambetta, 76183 Rouen cedex, France. Electronic address: marion_rachel@hotmail.com.
authors.forename: Rachel
authors.initials: R
authors.lastname: Marion-Letellier
authors.affiliation: INSERM Unit UMR1073, Rouen University and Rouen University hospital, 22, boulevard Gambetta, 76183 Rouen cedex, France; Department of Gastroenterology, Rouen University Hospital, 1 rue de Germont, 76031 Rouen cedex, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Savoye
authors.affiliation: Division of Gastroenterology, University of Calgary, Alberta, Canada.
authors.forename: Subrata
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D015777:Eicosanoids / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D047495:PPAR gamma / Q000737:chemistry / Q000378:metabolism*
chemical_list: D015777:Eicosanoids; D005227:Fatty Acids; D047495:PPAR gamma
keywords: Eicosanoids; Leukotrienes; PPAR gamma; Polyunsaturated fatty acids; Prostaglandins