title: Pentraxin 3 and Platelet Activation in Obese Patients After Gastric Banding.
abstract: BACKGROUND
  Circulating pentraxin 3 (PTX3), the main regulator of the inflammatory response, rapidly increases following cardiovascular events, and low PTX3 is associated with high body mass index.
  
  
  RESULTS
  We conducted a 12-month longitudinal study, to test the hypothesis that laparoscopic adjustable gastric banding (LAGB)-induced weight loss was associated with changes in platelet activation markers and PTX3. Twelve obese patients, scheduled to undergo LAGB, were enrolled at the University Obesity Center. Urinary 11-dehydro-thromboxane (Tx)B2excretion rate was measured on radioimmunoassay, and PTX3 and CD40L were determined on immunoassay. Plasma PTX3 increased by 178.8 and 214.9% (P<0.0001), respectively, 6 and 12 months after LAGB. High-sensitivity CRP decreased by 24 and 29.7% (P<0.0001), whereas CD40L decreased by 64.3 and 58.6% (P=0.002), respectively. Urinary 11-dehydro-TxB2decreased from 1,443 to 715 and 564 pg/mg creatinine, respectively 6 months and 12 months after LAGB (P<0.0001). PTX3 was inversely related to platelet activation markers, 11-dehydro-TxB2and CD40L. Moreover, multiple regression analysis on pooled data showed that plasma PTX3 was an independent predictor of urinary 11-dehydro-TxB2.
  
  
  CONCLUSIONS
  There is an association between inflammation, platelet activation and metabolic dysfunction in obesity, and PTX3 is a key player within these circuits.
authors.affiliation: Internal Medicine and Center of Excellence on Aging, "G. d'Annunzio" University of Chieti.
authors.forename: Francesca
authors.initials: F
authors.lastname: Santilli
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Guagnano
authors.forename: Paolo
authors.initials: P
authors.lastname: Innocenti
authors.forename: Liberato
authors.initials: L
authors.lastname: Aceto
authors.forename: Natale
authors.initials: N
authors.lastname: Vazzana
authors.forename: Stefano
authors.initials: S
authors.lastname: Lattanzio
authors.forename: Rossella
authors.initials: R
authors.lastname: Liani
authors.forename: Romina
authors.initials: R
authors.lastname: Tripaldi
authors.forename: Valeria
authors.initials: V
authors.lastname: Creato
authors.forename: Mario
authors.initials: M
authors.lastname: Romano
authors.forename: Giovanni
authors.initials: G
authors.lastname: Davì
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D023201:CD40 Ligand / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000601:surgery* / Q000652:urine; D015539:Platelet Activation; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D013929:Thromboxane B2 / Q000031:analogs & derivatives / Q000652:urine; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D023201:CD40 Ligand; D000683:Serum Amyloid P-Component; D013929:Thromboxane B2; D000099153:Pentraxins; C049235:11-dehydro-thromboxane B2