title: A pathway map of glutamate metabolism.
abstract: Glutamate metabolism plays a vital role in biosynthesis of nucleic acids and proteins. It is also associated with a number of different stress responses. Deficiency of enzymes involved in glutamate metabolism is associated with various disorders including gyrate atrophy, hyperammonemia, hemolytic anemia, γ-hydoxybutyric aciduria and 5-oxoprolinuria. Here, we present a pathway map of glutamate metabolism representing metabolic intermediates in the pathway, 107 regulator molecules, 9 interactors and 3 types of post-translational modifications. This pathway map provides detailed information about enzyme regulation, protein-enzyme interactions, post-translational modifications of enzymes and disorders due to enzyme deficiency. The information included in the map was based on published experimental evidence reported from mammalian systems.
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India.|School of Biotechnology, KIIT University, Bhubaneswar, 751 024, India.
authors.forename: Soujanya D
authors.initials: SD
authors.lastname: Yelamanchi
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India.|Manipal University, Madhav Nagar, Manipal, 576104, India.
authors.forename: Savita
authors.initials: S
authors.lastname: Jayaram
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India.|Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, 690525, India.
authors.forename: Joji Kurian
authors.initials: JK
authors.lastname: Thomas
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India.
authors.forename: Seetaramanjaneyulu
authors.initials: S
authors.lastname: Gundimeda
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India.|School of Biotechnology, KIIT University, Bhubaneswar, 751 024, India.
authors.forename: Aafaque Ahmad
authors.initials: AA
authors.lastname: Khan
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India.|Kasturba Medical College, Manipal University, Mangalore, 576 104, India.
authors.forename: Anish
authors.initials: A
authors.lastname: Singhal
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India.|YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, 575 018, India.
authors.forename: T S
authors.initials: TS
authors.lastname: Keshava Prasad
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine, Baltimore, MD, 21205, USA.|Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.|Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.|Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
authors.forename: Akhilesh
authors.initials: A
authors.lastname: Pandey
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India. somani@ibioinformatics.org.
authors.forename: B L
authors.initials: BL
authors.lastname: Somani
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India. harsha@ibioinformatics.org.|School of Biotechnology, KIIT University, Bhubaneswar, 751 024, India. harsha@ibioinformatics.org.|YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, 575 018, India. harsha@ibioinformatics.org.
authors.forename: Harsha
authors.identifier: http://orcid.org/0000-0002-4118-6855
authors.initials: H
authors.lastname: Gowda
keywords: Activators; Feedback regulation; Glutamine and inhibitors