title: Anti-Hu Antibody-associated Paraneoplastic Neurological Syndrome Showing Peripheral Neuropathy and Atypical Multifocal Brain Lesions.
abstract: A 64-year-old Japanese woman presented with a three-month history of progressive numbness and weakness of the lower extremities. A neurological examination and nerve conduction study indicated sensorimotor polyneuropathy. Since the serum anti-Hu antibody titer was remarkably elevated, paraneoplastic neurological syndrome was highly suspected. A thoracoscopic biopsy of the hilar lymph nodes, in which (18)F-fluorodeoxyglucose uptake was obviously increased, revealed pathological findings for small-cell lung cancer (SCLC). Subsequently, the patient presented with generalized tonic-clonic seizures, and cerebral MRI showed reversible multifocal brain lesions, considered to reflect paraneoplastic encephalopathy. After two courses of chemotherapy for SCLC, the brain lesions totally disappeared.
authors.affiliation: Department of Neurology, Gunma University Graduate School of Medicine, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Shibata
authors.forename: Megumi
authors.initials: M
authors.lastname: Uchida
authors.forename: Setsuki
authors.initials: S
authors.lastname: Tsukagoshi
authors.forename: Koichi
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Aya
authors.initials: A
authors.lastname: Yamaguchi
authors.forename: Natsumi
authors.initials: N
authors.lastname: Furuta
authors.forename: Kouki
authors.initials: K
authors.lastname: Makioka
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Maeno
authors.forename: Yukio
authors.initials: Y
authors.lastname: Fujita
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurabayashi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ikeda
mesh_terms: D000974:Antibodies, Antinuclear; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood; D001921:Brain / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000150:complications / Q000175:diagnosis*; D051959:ELAV Proteins / Q000276:immunology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000175:diagnosis*; D020361:Paraneoplastic Syndromes, Nervous System / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000175:diagnosis*
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D051959:ELAV Proteins