title: Chronic Myelogenous Leukemia Relapse Presenting With Central Nervous System Blast Crisis and Bilateral Optic Nerve Infiltration.
abstract: Bilateral, simultaneous optic nerve sheath infiltration as a manifestation of leukemia relapse is very rare. A 45-year-old woman with chronic myelogenous leukemia was successfully treated to cytogenetic bone marrow remission 1 year previously and maintained on imatinib. She developed total bilateral blindness with marked, bilateral optic disc edema and evidence of bilateral optic nerve infiltration on magnetic resonance imaging. Cerebrospinal fluid cytology confirmed central nervous system (CNS) blast crisis. She recovered visual acuity of 20/20 in the right eye, and 20/25 in the left eye with salvage systemic and intrathecal chemotherapy before radiation therapy. Our report underscores the importance of timely and aggressive intervention of blast crisis of the CNS and the need for CNS penetrating induction and maintenance therapy.
authors.affiliation: Department of Surgery (JNM), North Bronx Health Network, Bronx, New York; Department of Ophthalmology & Visual Sciences (JNM), Albert Einstein College of Medicine of Yeshiva University, New York; Department of Ophthalmology (MAF), King Faisal Specialist Hospital & Research Center, Riyadh; Department of Ophthalmology (MAF), Cairo University Medical School, Cairo, Egypt; Department of Hematologic Pathology (RMAN), King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia; Department of Hematology-Oncology (WC), King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia; and Department of Neuro-Radiology (MAD), King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
authors.forename: Joyce N
authors.initials: JN
authors.lastname: Mbekeani
authors.forename: Maaly
authors.initials: M
authors.lastname: Abdel Fattah
authors.forename: Randa M
authors.initials: RM
authors.lastname: Al Nounou
authors.forename: Wahiba
authors.initials: W
authors.lastname: Chebbo
authors.forename: Mohammed Asif
authors.initials: MA
authors.lastname: Dogar
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001752:Blast Crisis / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D005260:Female; D016313:Genes, abl / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D017254:Leukemic Infiltration / Q000188:drug therapy / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D019574:Optic Nerve Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D060888:Real-Time Polymerase Chain Reaction; D016879:Salvage Therapy; D041623:Tomography, Optical Coherence