title: Acute macular neuroretinopathy associated with systemic lupus erythematosus.
abstract: Acute macular neuroretinopathy (AMN) is a rare disorder that presents with abrupt visual change with wedge-shaped or flower-like lesions pointing towards the fovea. Ischemic insults to the retinal capillary plexus may be important for development of this disease. While many case reports have been published on AMN, none have described AMN in association with systemic lupus erythematosus (SLE). Here, we report a case of AMN associated with newly-diagnosed SLE. We speculate that in patients with lupus flares, immune complex-mediated vascular injury and microvascular thrombosis may disrupt the deep retinal capillary network, causing ischemic damages to the outer retina and leading to the development of AMN. AMN can develop in patients with lupus flares, and must be considered as an SLE-associated ophthalmologic complication. To the best of our knowledge, this is the first case report of AMN associated with SLE.
authors.affiliation: Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: D H
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: S C
authors.initials: SC
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea minkim76@hotmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Kim
mesh_terms: D000208:Acute Disease; D000328:Adult; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D008775:Methylprednisolone / Q000008:administration & dosage; D012164:Retinal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014786:Vision Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone
keywords: Acute macular neuroretinopathy; optical coherence tomography; systemic lupus erythematosus