title: Family History of Cancer and Head and Neck Cancer Risk in a Chinese Population.
abstract: BACKGROUND
  The aim of this study was to investigate whether family history of cancer is associated with head and neck cancer risk in a Chinese population.
  
  
  METHODS
  This case-control study included 921 cases and 806 controls. Recruitment was from December 2010 to January 2015 in eight centers in East Asia. Controls were matched to cases with reference to sex, 5-year age group, ethnicity, and residence area at each of the centers.
  
  
  RESULTS
  We observed an increased risk of head and neck cancer due to first degree family history of head and neck cancer, but after adjustment for tobacco smoking, alcohol drinking and betel quid chewing the association was no longer apparent. The adjusted OR were 1.10 (95% CI=0.80-1.50) for family history of tobacco-related cancer and 0.96 (95%CI=0.75-1.24) for family history of any cancer with adjustment for tobacco, betel quid and alcohol habits. The ORs for having a first-degree relative with HNC were higher in all tobacco/ alcohol subgroups.
  
  
  CONCLUSIONS
  We did not observe a strong association between family history of head and neck cancer and head and neck cancer risk after taking into account lifestyle factors. Our study suggests that an increased risk due to family history of head and neck cancer may be due to shared risk factors. Further studies may be needed to assess the lifestyle factors of the relatives.
authors.affiliation: Division of Public Health, Department of Family and Preventive Medicine, and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, U.S.A. E-mail : mia.hashibe@utah.edu.
authors.forename: Yu-Hui Jenny
authors.initials: YH
authors.lastname: Huang
authors.forename: Yuan-Chin Amy
authors.initials: YC
authors.lastname: Lee
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Chien-Jen
authors.initials: CJ
authors.lastname: Chen
authors.forename: Wan-Lun
authors.initials: WL
authors.lastname: Hsu
authors.forename: Pen-Jen
authors.initials: PJ
authors.lastname: Lou
authors.forename: Cairong
authors.initials: C
authors.lastname: Zhu
authors.forename: Jian
authors.initials: J
authors.lastname: Pan
authors.forename: Hongbing
authors.initials: H
authors.lastname: Shen
authors.forename: Hongxia
authors.initials: H
authors.lastname: Ma
authors.forename: Lin
authors.initials: L
authors.lastname: Cai
authors.forename: Baochang
authors.initials: B
authors.lastname: He
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhou
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Ji
authors.forename: Baosen
authors.initials: B
authors.lastname: Zhou
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Zuo-Feng
authors.initials: ZF
authors.lastname: Zhang
authors.forename: Min
authors.initials: M
authors.lastname: Dai
authors.forename: Mia
authors.initials: M
authors.lastname: Hashibe
mesh_terms: D000428:Alcohol Drinking / Q000453:epidemiology*; D001114:Areca; D044466:Asian People; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005190:Family; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology*; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology*