title: First phytochemical investigation of secondary metabolites of Euphorbia davidii Subils. and antiproliferative activity of its extracts.
abstract: The present work is the first phytochemical investigation of Euphorbia davidii Subils. After multistep separation process, three flavonoid glycosides were obtained from the ethyl acetate soluble fraction of the methanol extract of the whole plant. The structures of the isolated compounds were determined as kaempferol 3-O-rhamnoside, myricetin 3-O-rhamnoside, and quercetin 3-O-rhamnoside. Aqueous and organic extracts of the plant were screened in vitro for antiproliferative activity against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma), A2780 (ovarian carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells, using the MTT assay. n-Hexane and chloroform extracts demonstrated moderately dose-dependent cell growth inhibitory activity against all four cell lines.
authors.affiliation: Department of Pharmacognosy, University of Szeged , Eötvös u. 6, H-6720 Szeged , Hungary.
authors.forename: Dóra
authors.initials: D
authors.lastname: Rédei
authors.affiliation: Department of Pharmacognosy, University of Szeged , Eötvös u. 6, H-6720 Szeged , Hungary.
authors.forename: Norbert
authors.initials: N
authors.lastname: Kúsz
authors.affiliation: Department of Pharmacognosy, University of Szeged , Eötvös u. 6, H-6720 Szeged , Hungary.
authors.forename: Máté
authors.initials: M
authors.lastname: Szabó
authors.affiliation: Department of Botany, Faculty of Agricultural and Food Sciences, University of West Hungary , Vár u. 2, H-9200 Mosonmagyaróvár , Hungary.
authors.forename: Gyula
authors.initials: G
authors.lastname: Pinke
authors.affiliation: Department of Pharmacodynamics and Biopharmacy, University of Szeged , Eötvös u. 6, H-6720 Szeged , Hungary.
authors.forename: István
authors.initials: I
authors.lastname: Zupkó
authors.affiliation: Department of Pharmacognosy, University of Szeged , Eötvös u. 6, H-6720 Szeged , Hungary.
authors.forename: Judit
authors.initials: J
authors.lastname: Hohmann
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation; D028481:Euphorbia / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D064209:Phytochemicals / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D064209:Phytochemicals; D010936:Plant Extracts
keywords: Euphorbia davidii; antiproliferative activity; flavonoid glycoside