title: Clinical characteristics and treatment outcome of Stevens-Johnson syndrome and toxic epidermal necrolysis.
abstract: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are erythematous skin lesions with blister formation accompanied by mucosal involvement. These conditions are considered to be life-threatening illnesses. Understanding the clinical presentation, risk factors, treatment options and results will be advantageous for physicians in the management of patients in the future. The aim of the present study was to review and analyze the clinical manifestations, drug implications, treatment and outcome of patients with SJS and/or TEN who had been hospitalized in a tertiary care center. All hospitalized patients with SJS and/or TEN during a 5-year period were retrospectively reviewed. The clinical severity was graded according to the score of toxic epidermal necrolysis (SCORTEN) scale. Clinical symptoms, diagnosis, possible precipitating factors, management and outcome data were collected for analysis. A total of 43 patients (mean age, 49.5 years) were hospitalized and classified into the SJS group (55.8%), SJS/TEN overlap group (20.9%) and TEN group (23.3%). The majority of the patients (90.7%) had mucocutaneous eruptions associated with oral drug administration. Allopurinol, anticonvulsants and antibiotics were the most common causative agents for the mucocutaneous eruption. Twenty-eight patients (65.1%) were treated with corticosteroids. The mortality rate was 6.9%. Comparison between the survival group and the non-survival group revealed that patient age >70 years (P=0.014) and body surface area involvement >20% (P<0.01) were the significant factors associated with mortality. The use of systemic steroids was higher in the survival group in comparison with the non-survival group (65.1 vs. 0%, respectively; P=0.014). The mucocutaneous eruptions in SJS and TEN are mostly caused by medication. With early recognition and treatment, the mortality rate in this study was lower than that in previous reports. Patient age and the area of mucocutaneous involvement were significant factors associated with mortality.
authors.affiliation: Department of Medicine, Division of Allergy and Immunology, Faculty of Medicine, Chulalongkorn University, Patumwan, Bangkok 10330, Thailand.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Chantaphakul
authors.affiliation: Department of Medicine, Division of Allergy and Immunology, Faculty of Medicine, Chulalongkorn University, Patumwan, Bangkok 10330, Thailand.
authors.forename: Thanomsak
authors.initials: T
authors.lastname: Sanon
authors.affiliation: Department of Medicine, Division of Allergy and Immunology, Faculty of Medicine, Chulalongkorn University, Patumwan, Bangkok 10330, Thailand.
authors.forename: Jettanong
authors.initials: J
authors.lastname: Klaewsongkram
keywords: Stevens-Johnson syndrome; drug reaction; toxic epidermal necrolysis