title: Timing of antiretroviral therapy initiation after diagnosis of recent human immunodeficiency virus infection and CD4(+) T-cell recovery.
abstract: We retrospectively examined the timing of antiretroviral therapy (ART) initiation and CD4(+) T-cell recovery over 36 months among recent human immunodeficiency virus (HIV) infections using BED (HIV-1 subtypes B, E and D) immunoglobulin G capture enzyme immunoassay (BED-CEIA). Regardless of baseline CD4(+) counts, individuals (n = 393) who initiated ART >2 months after diagnosis had significantly decreased probability and rate of achieving CD4(+) counts ≥900 cells/μL or ≥600 cells/μL than those individuals (n = 135) who started ART earlier (≤2 months). But the mean CD4(+) counts in two groups converged after 30 months of treatment. Early ART initiation leads to accelerated CD4(+) recovery, but does not offer a long-term advantage in CD4(+) counts.
authors.affiliation: Department of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Dehong Prefecture Centre for Disease Control and Prevention, Mangshi, Yunnan Province, China.
authors.forename: S
authors.initials: S
authors.lastname: Duan
authors.affiliation: National Centre for AIDS/STD Control and Prevention (NCAIDS), Chinese Centre for Disease Control and Prevention (China CDC), Beijing, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Dehong Prefecture Centre for Disease Control and Prevention, Mangshi, Yunnan Province, China.
authors.forename: R
authors.initials: R
authors.lastname: Ye
authors.affiliation: Dehong Prefecture Centre for Disease Control and Prevention, Mangshi, Yunnan Province, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Dehong Prefecture Centre for Disease Control and Prevention, Mangshi, Yunnan Province, China.
authors.forename: S
authors.initials: S
authors.lastname: Yao
authors.affiliation: Dehong Prefecture Centre for Disease Control and Prevention, Mangshi, Yunnan Province, China.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: Dehong Prefecture Centre for Disease Control and Prevention, Mangshi, Yunnan Province, China.
authors.forename: L
authors.initials: L
authors.lastname: Xiang
authors.affiliation: National Centre for AIDS/STD Control and Prevention (NCAIDS), Chinese Centre for Disease Control and Prevention (China CDC), Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Yunnan Centre for Disease Control and Prevention, Kuming, Yunnan Province, China.
authors.forename: L
authors.initials: L
authors.lastname: Lu
authors.affiliation: Yunnan Centre for Disease Control and Prevention, Kuming, Yunnan Province, China.
authors.forename: M
authors.initials: M
authors.lastname: Jia
authors.affiliation: Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, USA.
authors.forename: R
authors.initials: R
authors.lastname: Detels
authors.affiliation: Department of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China. Electronic address: nhe@shmu.edu.cn.
authors.forename: N
authors.initials: N
authors.lastname: He
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D002681:China; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral; D061665:Time-to-Treatment; D016896:Treatment Outcome; D019562:Viral Load; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral
keywords: Antiretroviral therapy; CD4(+)T cells; China; human immunodeficiency virus; immune recovery; recent infection