title: Cerebral blood flow and oximetry response to blood transfusion in relation to chronological age in preterm infants.
abstract: Preterm infants frequently receive blood transfusion (BT) and the aim of this study was to measure the effect of BT on cerebral blood flow and oxygenation in preterm infants in relation to chronological age.
  
  
  
  Preterm infants undergoing intensive care recruited to three chronological age groups: 1 to 7 (Group 1; n=20), 8 to 28 (Group 2; n=21) & ≥29days of life (Group 3; n=18).
  
  
  
  Pre and post-BT anterior cerebral artery (ACA) time averaged mean velocity (TAMV) and superior vena cava (SVC) flow were measured. Cerebral Tissue Haemoglobin Index (cTHI) and Oxygenation Index (cTOI) were measured from 15-20min before to 15-20min post-BT using NIRS. Vital parameters and blood pressure were measured continuously.
  
  
  
  Mean BP increased significantly, and there was no significant change in vital parameters following BT. Pre-BT ACA TAMV was higher in Group 2 and 3 compared to Group 1 (p<0.001). Pre-BT ACA TAMV decreased significantly (p≤0.04) in all 3 groups; pre-BT SVC flow decreased significantly in Group 1 (p=0.03) and Group 3 (p<0.001) following BT. Pre-BT cTOI was significantly lower in Group 3 compared to Group 1 (p=0.02). cTHI (p<0.001) and cTOI (p<0.05) increased significantly post-BT in all three groups. PDA had no effect on these measurements.
  
  
  
  Baseline cTOI decreases and ACA TAMV increases with increasing chronological age. Blood transfusion increased cTOI and cTHI and decreased ACA TAMV in all groups. PDA had no impact on the baseline cerebral oximetry and blood flow as well as changes following blood transfusion.
authors.affiliation: Neonatal Unit, Homerton University Hospital NHS Foundation Trust, Homerton Row, London E9 6SR, UK; Centre for Genomics and Child Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK; Portland Hospital, London, UK. Electronic address: jayanta.banerjee@imperial.nhs.uk.
authors.forename: J
authors.initials: J
authors.lastname: Banerjee
authors.affiliation: Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: t.leung@ucl.ac.uk.
authors.forename: T S
authors.initials: TS
authors.lastname: Leung
authors.affiliation: Neonatal Unit, Homerton University Hospital NHS Foundation Trust, Homerton Row, London E9 6SR, UK; Centre for Genomics and Child Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK; Department of Paediatrics, SDM Medical College and Hospitals, Dharwad, India. Electronic address: Narendra.aladangady@homerton.nhs.uk.
authors.forename: N
authors.initials: N
authors.lastname: Aladangady
mesh_terms: D001803:Blood Transfusion / Q000379:methods; D002560:Cerebrovascular Circulation; D005260:Female; D005865:Gestational Age; D006801:Humans; D062071:Infant, Extremely Premature / Q000097:blood / Q000502:physiology*; D007231:Infant, Newborn; D008297:Male; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D065227:Transfusion Reaction / Q000097:blood / Q000000981:diagnostic imaging*
chemical_list: D010100:Oxygen
keywords: Blood transfusion; Cerebral blood flow; Cerebral oximetry