title: PEGylated Nanoparticles Obtained through Emulsion Polymerization as Paclitaxel Carriers.
abstract: Polymer nanoparticles (NPs) represent a promising way to deliver poorly water-soluble anticancer drugs without the use of unwanted excipients, whose presence can be the cause of severe side effects. In this work, a Cremophor-free formulation for paclitaxel (PTX) has been developed by employing PEGylated polymer nanoparticles (NPs) as drug delivery carriers based on modified poly(ε-caprolactone) macromonomers and synthesized through free radical emulsion polymerization. Paclitaxel was loaded in the NPs in a postsynthesis process which allowed to obtain a drug concentration suitable for in vivo use. In vivo experiments on drug biodistribution and therapeutic efficacy show comparable behavior between the NPs and the Cremophor formulation, also showing good tolerability of the new formulation proposed.
authors.affiliation: Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano , Via Mancinelli 7, 20131 Milano, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Colombo
authors.affiliation: Department of Oncology, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milano, Italy.
authors.forename: Lavinia
authors.initials: L
authors.lastname: Morosi
authors.affiliation: Department of Oncology, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milano, Italy.
authors.forename: Ezia
authors.initials: E
authors.lastname: Bello
authors.affiliation: Department of Oncology, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milano, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Ferrari
authors.affiliation: Department of Oncology, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milano, Italy.
authors.forename: Simonetta Andrea
authors.initials: SA
authors.lastname: Licandro
authors.affiliation: Department of Oncology, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milano, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Lupi
authors.affiliation: Department of Oncology, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milano, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Ubezio
authors.affiliation: Institute for Chemical and Bioengineering, ETH Zurich , Vladimir Prelog Weg, CH-8093 Zurich, Switzerland.
authors.forename: Massimo
authors.initials: M
authors.lastname: Morbidelli
authors.affiliation: Department of Oncology, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milano, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Zucchetti
authors.affiliation: Department of Oncology, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milano, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: D'Incalci
authors.affiliation: Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano , Via Mancinelli 7, 20131 Milano, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Moscatelli
authors.affiliation: Department of Oncology, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri , Via La Masa 19, 20156 Milano, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Frapolli
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*
chemical_list: D011108:Polymers; D011092:Polyethylene Glycols; D017239:Paclitaxel
keywords: Breast Cancer; Cremophor; Drug Delivery; Emulsion Polymerization; Nanoparticles; Paclitaxel