title: Inherited thrombophilia profile in patients with recurrent miscarriages: Experience from a tertiary care center in north India.
abstract: The cause of recurrent miscarriage (RM) remains unexplained in approximately 30% to 50% cases. The association of inherited thrombotic factors and RM patients has not been documented from the northern part of India. A total of 40 patients had been investigated for inherited thrombophilia workup (protein C, protein S [PS], antithrombin III, and factor V Leiden [FVL] mutation) over a period of 10 years (2005 to 2014). RM patients were divided in to three groups. Group I (only 1st trimester loss), group II (only 2nd and 3rd trimester), and group III (mixed). Each group comprised of the following numbers of patients respectively: I, 24; II, 2; III, 14. Heterozygous FVL mutation was found in 10% (4/40) cases. PS deficiency was detected in 2.7% (1/37) cases. In the present study FVL and PS were seems to be associated with a subset of patients however further studies with larger numbers of patients are recommended for better evaluation.
authors.affiliation: Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Narender
authors.initials: N
authors.lastname: Kumar
authors.affiliation: Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Ahluwalia
authors.affiliation: Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Reena
authors.initials: R
authors.lastname: Das
authors.affiliation: Department of Obstetrics & Gynecology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Rohilla
authors.affiliation: Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Bose
authors.affiliation: Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Hari
authors.initials: H
authors.lastname: Kishan
authors.affiliation: Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: Neelam
authors.initials: N
authors.lastname: Varma
keywords: Abortion, habitual; Factor V Leiden; Protein S; Thrombophilia