title: Hollow Mesoporous Silica Nanocarriers with Multifunctional Capping Agents for In Vivo Cancer Imaging and Therapy.
abstract: Efficient drug loading and selectivity in drug delivery are two key features of a good drug-carrier design. Here we report on such a drug carrier formed by using hollow mesoporous silica nanoparticles (HMS NPs) as the core and specifically designed multifunctional amphiphilic agents as the encapsulating shell. These nanocarriers combine the advantages of the HMS NP core (favorable physical and structural properties) and the versatility of an organic-based shell (e.g., specificity in chemical properties and modifiability). Moreover, both the properties of the core and the shell can be independently varied. The varied core and shell could then be integrated into a single device (drug carrier) to provide efficient and specific drug delivery. In vitro and in vivo data suggests that these drug nanocarriers are biocompatible and are able to deliver hydrophobic drugs selectively to target tumor cells. After the break of the pH-labile linkages in the shell, the drug payload can be released and the tumor cells are killed.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.
authors.forename: Shun
authors.initials: S
authors.lastname: Yang
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.
authors.forename: Dongyun
authors.initials: D
authors.lastname: Chen
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.
authors.forename: Najun
authors.initials: N
authors.lastname: Li
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Xu
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, Ontario, N2L 3G1, Canada.
authors.forename: Frank
authors.initials: F
authors.lastname: Gu
authors.affiliation: Department of Chemical & Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 117576, Singapore.
authors.forename: Jianping
authors.initials: J
authors.lastname: Xie
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.
authors.forename: Jianmei
authors.initials: J
authors.lastname: Lu
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003952:Diagnostic Imaging / Q000379:methods*; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005260:Female; D005453:Fluorescence; D006367:HeLa Cells; D006801:Humans; D007275:Injections, Intravenous; D007624:KB Cells; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D009928:Organ Specificity / Q000187:drug effects; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D004337:Drug Carriers; D012822:Silicon Dioxide; D004317:Doxorubicin
keywords: biocompatible materials; core-shell materials; drug delivery; hollow spheres; mesoporous materials