title: Mitigation of Fumonisin Biomarkers by Green Tea Polyphenols in a High-Risk Population of Hepatocellular Carcinoma.
abstract: Green tea polyphenols (GTP) are highly effective in inhibiting a variety of tumorigenic effects induced by carcinogens. In this study we assessed GTP mitigation on biomarkers of fumonisin B1 (FB1), a class 2B carcinogen, in blood and urine samples collected from an intervention trial. A total of 124 exposed people were recruited and randomly assigned to low-dose (GTP 500 mg, n = 42), high-dose (GTP 1,000 mg, n = 41) or placebo (n = 41) for 3 months. After one-month of intervention, urinary FB1 was significantly decreased in high-dose group compared to that of placebo group (p = 0.045), with reduction rates of 18.95% in the low-dose group and 33.62% in the high-dose group. After three-month intervention, urinary FB1 showed significant decrease in both low-dose (p = 0.016) and the high-dose (p = 0.0005) groups compared to that of both placebo group and baseline levels, with reduction rates of 40.18% in the low-dose group and 52.6% in the high-dose group. GTP treatment also significantly reduced urinary excretion of sphinganine (Sa), sphingosine (So), and Sa/So ratio, but had no effect on serum Sa, So, and Sa/So ratio. Analysis with mixed-effect model revealed significant interactions between time and treatment effects of GTP on both urinary free FB1 levels and Sa/So ratios.
authors.affiliation: Department of Environmental Health Science, University of Georgia, Athens, GA 30602, USA.
authors.forename: Kathy S
authors.initials: KS
authors.lastname: Xue
authors.affiliation: Department of Environmental Health Science, University of Georgia, Athens, GA 30602, USA.
authors.forename: Lili
authors.initials: L
authors.lastname: Tang
authors.affiliation: Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
authors.forename: Qingsong
authors.initials: Q
authors.lastname: Cai
authors.affiliation: Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA 30602, USA.
authors.forename: Ye
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Guangxi Cancer Institute, Nanning, Guangxi, 530021, China.
authors.forename: Jianjia
authors.initials: J
authors.lastname: Su
authors.affiliation: Department of Environmental Health Science, University of Georgia, Athens, GA 30602, USA.
authors.forename: Jia-Sheng
authors.initials: JS
authors.lastname: Wang
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood / Q000652:urine; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000188:drug therapy / Q000652:urine; D005260:Female; D037341:Fumonisins / Q000097:blood / Q000652:urine; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000188:drug therapy / Q000652:urine; D008297:Male; D008875:Middle Aged; D059808:Polyphenols / Q000008:administration & dosage* / Q000737:chemistry; D013662:Tea / Q000737:chemistry*
chemical_list: D014408:Biomarkers, Tumor; D037341:Fumonisins; D059808:Polyphenols; D013662:Tea; C056933:fumonisin B1