title: [Mixed Episodes in Bipolar Disorders--Changes in DSM-5 and Treatment Recommendations].
abstract: Mixed episodes in the course of affective disorders are challenging for any psychiatrist, because they are often characterized by a complicated and difficult treatment course (e. g. higher suicide rates) and a worse treatment outcome. In DSM-5, one of the main changes is that the diagnosis of a mixed episode was disestablished and replaced with affective episodes with so called "mixed features". This alteration markedly reduces the diagnostic threshold. The available literature on pharmacological treatment of mixed episodes is not sufficient; however, treatment with atypical antipsychotics, especially olanzapine and aripiprazole and the mood stabilizers valproate and carmabazepine has proved to be beneficial.
authors.affiliation: Charité, Klinik für Psychiatrie und Psychotherapie, Campus Mitte.
authors.forename: S
authors.initials: S
authors.lastname: Köhler
authors.affiliation: Charité, Klinik für Psychiatrie und Psychotherapie, Campus Mitte.
authors.forename: L A
authors.initials: LA
authors.lastname: Stöver
authors.affiliation: Charité, Klinik für Psychiatrie und Psychotherapie, Campus Mitte.
authors.forename: P
authors.initials: P
authors.lastname: Sterzer
mesh_terms: D018692:Antimanic Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology* / Q000628:therapy*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D011570:Psychiatry
chemical_list: D018692:Antimanic Agents; D014150:Antipsychotic Agents