title: The effectiveness of exercise programmes in patients with multiple myeloma: A literature review.
abstract: A limited number of clinical studies have investigated the effectiveness of participation in exercise training programmes for patients with multiple myeloma (MM), exploring the different biomedical, physical, psychological and quality of life. The aim of this literature review is to evaluate current quantitative and qualitative evidence concerning the effectiveness of participation in exercise programmes for patients with MM in improving physiological and/or psychological status. A literature search encompassing studies published between January 1998 and July 2013 was conducted through ten electronic databases. This search was further expanded through citation chaining, manual grey literature searches, and peer review consultation. In total, seven interventional studies were identified and appraised using Critical Appraisal Skill Programme (CASP) or Centre for Evidence-Based Management of Amsterdam (CEBMa). Though the majority of the studies presented encouraging data, however, three studies that implemented individualized exercise interventions for patients at different stages of MM and myeloablative treatment showed mixed results. In conclusion, the effectiveness of participation in exercise programmes remains unclear for patients with MM, as the studies reviewed were flawed by relatively weak methodological approaches.
authors.affiliation: Department of Sport and Health Science, Oxford Brookes University, Oxford, UK; Rehabilitation Department, Parkway East Hospital, Singapore. Electronic address: jiahuigan1@gmail.com.
authors.forename: J H
authors.initials: JH
authors.lastname: Gan
authors.affiliation: Rehabilitation Department, Parkway East Hospital, Singapore.
authors.forename: C Y L
authors.initials: CY
authors.lastname: Sim
authors.affiliation: Doctoral Training Center, University of Oxford, Oxford, UK.
authors.forename: L A
authors.initials: LA
authors.lastname: Santorelli
mesh_terms: D015444:Exercise; D006801:Humans; D009101:Multiple Myeloma / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D011788:Quality of Life; D012107:Research Design
keywords: Cancer rehabilitation; Exercise; Functional mobility; Multiple myeloma; Physiotherapy