title: The cystic fibrosis microbiome in an ecological perspective and its impact in antibiotic therapy.
abstract: The recent focus on the cystic fibrosis (CF) complex microbiome has led to the recognition that the microbes can interact between them and with the host immune system, affecting the disease progression and treatment routes. Although the main focus remains on the interactions between traditional pathogens, growing evidence supports the contribution and the role of emergent species. Understanding the mechanisms and the biological effects involved in polymicrobial interactions may be the key to improve effective therapies and also to define new strategies for disease control. This review focuses on the interactions between microbe-microbe and host-microbe, from an ecological point of view, discussing their impact on CF disease progression. There are increasing indications that these interactions impact the success of antimicrobial therapy. Consequently, a new approach where therapy is personalized to patients by taking into account their individual CF microbiome is suggested.
authors.affiliation: CEB-Centre of Biological Engineering, LIBRO-Laboratório de Investigação em Biofilmes Rosário Oliveira, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.
authors.forename: Andreia P
authors.initials: AP
authors.lastname: Magalhães
authors.affiliation: LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Department of Chemical Engineering, Faculty of Engineering, University of Porto, 4200-465, Porto, Portugal.
authors.forename: Nuno F
authors.initials: NF
authors.lastname: Azevedo
authors.affiliation: CEB-Centre of Biological Engineering, LIBRO-Laboratório de Investigação em Biofilmes Rosário Oliveira, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.
authors.forename: Maria O
authors.initials: MO
authors.lastname: Pereira
authors.affiliation: CEB-Centre of Biological Engineering, LIBRO-Laboratório de Investigação em Biofilmes Rosário Oliveira, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal. supat@deb.uminho.pt.
authors.forename: Susana P
authors.initials: SP
authors.lastname: Lopes
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003550:Cystic Fibrosis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D006801:Humans; D064307:Microbiota / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibiotic therapy; Cystic fibrosis; Ecological perspective; Microbe–host interactions; Microbe–microbe interactions; Polymicrobial biofilms