title: [Genotoxic and Mutagenic Properties of Synthetic Betulinic and Betulonic Acids].
abstract: Synthesis of betulinic acid was performed from the birch bark extract (Betula pendula). Betulonic acid was intermediate of the synthesis. Both acids were isolated with purity 95%. Genotoxicity and mutagenicity of obtained compounds were analyzed by Ames test and SOS chromotest, none of these properties have been detected.
authors.forename: T S
authors.initials: TS
authors.lastname: Frolova
authors.forename: T P
authors.initials: TP
authors.lastname: Kukina
authors.forename: O I
authors.initials: OI
authors.lastname: Sinitsyna
mesh_terms: D004249:DNA Damage; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D009153:Mutagens; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D053978:Pentacyclic Triterpenes; D013014:SOS Response, Genetics / Q000187:drug effects*; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000094062:Betulinic Acid
chemical_list: D009153:Mutagens; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; C118308:betulonic acid; D009828:Oleanolic Acid; D000094062:Betulinic Acid