title: Studies on lipase-catalyzed asymmetric synthesis of (S)-(hydroxymethyl)glutamic acid (HMG).
abstract: (S)-(Hydroxymethyl)glutamic acid was successfully synthesized in total 12 % yield over eight steps from tris(hydroxymethyl)aminomethane hydrochloride (Tris·HCl), employing lipase TL-induced enantioselective acetylation of a prochiral 1,3-diol as the key step.
authors.affiliation: Yokohama City University, Seto 22-2, Kanazawa-ku, Yokohama, 236-0027 Japan.
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Yoshioka
authors.affiliation: Yokohama City University, Seto 22-2, Kanazawa-ku, Yokohama, 236-0027 Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Oikawa
keywords: (Hydroxymethyl)glutamic acid; Asymmetric synthesis; Glutamate analogs; Lipase-catalyzed acetylation