title: Age-Specific Peculiarities of Modulation of Blood Aldo-Keto Reductase Isoenzyme Spectrum.
abstract: The aldo-keto reductase spectrum of the blood was studied at different stages of ontogeny to elucidate the role of reduction pathway in utilization of the carbonyl products of free radical oxidation in modulation of organism sensitivity to the damaging effect of stress during ontogeny. The studies revealed the age-specific changes in aldo-keto reductase spectrum in the blood. An analogy of the aldo-keto reductase spectrum structure in animals of early maturity and in old rats was found. The appearance of age specificity of the aldo-keto reductase spectrum in the blood creates metabolic prerequisites for changes in the efficiency of utilization of carbonyl products of free radical oxidation via their reductive transformation.
authors.affiliation: I. P. Pavlov Ryazan' State Medical University, Ministry of Health of the Russian Federation, Ryazan', Russia. vaddavydov@mail.ru.
authors.forename: V V
authors.initials: VV
authors.lastname: Davydov
mesh_terms: D000367:Age Factors; D000449:Aldehyde Reductase / Q000097:blood* / Q000378:metabolism; D000074408:Aldo-Keto Reductases; D000818:Animals; D007527:Isoenzymes / Q000097:blood* / Q000378:metabolism; D007700:Kinetics; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013379:Substrate Specificity
chemical_list: D007527:Isoenzymes; D000074408:Aldo-Keto Reductases; D000449:Aldehyde Reductase
keywords: aldo-keto reductases; carbonyl stress; ontogeny