title: Structural Aspects of Bacterial Outer Membrane Protein Assembly.
abstract: The outer membrane of Gram-negative bacteria is predominantly populated by β-Barrel proteins and lipid anchored proteins that serve a variety of biological functions. The proper folding and assembly of these proteins is essential for bacterial viability and often plays a critical role in virulence and pathogenesis. The β-barrel assembly machinery (Bam) complex is responsible for the proper assembly of β-barrels into the outer membrane of Gram-negative bacteria, whereas the localization of lipoproteins (Lol) system is required for proper targeting of lipoproteins to the outer membrane.
authors.affiliation: Department of Biochemistry, University of Toronto, Medical Science Building, Rm. 5366, 1 King's College Circle, Toronto, ON, Canada, M5S 1A8. charles.calmettes@utoronto.ca.
authors.forename: Charles
authors.initials: C
authors.lastname: Calmettes
authors.affiliation: Department of Biochemistry, University of Toronto, Medical Science Building, Rm. 5366, 1 King's College Circle, Toronto, ON, Canada, M5S 1A8. andrew.judd@mail.utoronto.ca.
authors.forename: Andrew
authors.initials: A
authors.lastname: Judd
authors.affiliation: Department of Biochemistry, University of Toronto, Medical Science Building, Rm. 5366, 1 King's College Circle, Toronto, ON, Canada, M5S 1A8. trevor.moraes@utoronto.ca.
authors.forename: Trevor F
authors.initials: TF
authors.lastname: Moraes
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry*; D008074:Lipoproteins / Q000378:metabolism; D017510:Protein Folding; D021381:Protein Transport
chemical_list: D001425:Bacterial Outer Membrane Proteins; D008074:Lipoproteins
keywords: Bam machinery; Lol pathway; Omp85 family; Outer membrane biogenesis; Protein trafficking