title: [Pulmonary hypoplasia: An analysis of cases over a 20-year period].
abstract: BACKGROUND
  Pulmonary hypoplasia is the most frequent congenital anomaly associated with perinatal mortality.
  
  
  METHODS
  A retrospective and descriptive review was conducted on cases of patients diagnosed with pulmonary hypoplasia between 1995 and 2014 in a tertiary university hospital. An analysis was made of the prenatal imaging, clinical manifestations, post-natal diagnostic tests, treatment and management, long-term follow up, and survival data.
  
  
  RESULTS
  A total of 60 cases were identified, all of them with prenatal imaging. Sixteen patients required foetal surgery. Congenital diaphragmatic hernia was the most frequent diagnosis. Main clinical presentation was respiratory distress with severe hypoxemia and high requirements of mechanical ventilation. Mortality rate was 47% within first 60 days of life, and 75% for the first day of life. Pneumonia and recurrent bronchitis episodes were observed during follow-up. They had a lung function obstructive pattern, and their quality of life and exercise tolerance was good.
  
  
  CONCLUSIONS
  High neonatal mortality and significant long-term morbidity associated with pulmonary hypoplasia requires an early diagnosis and a specialised multidisciplinary team management.
authors.affiliation: Hospital Universitario Vall d́Hebron, Barcelona, España. Electronic address: yannypaola@yahoo.es.
authors.forename: Yanny Paola
authors.initials: YP
authors.lastname: Delgado-Peña
authors.affiliation: Hospital Universitario Vall d́Hebron, Barcelona, España.
authors.forename: Alba
authors.initials: A
authors.lastname: Torrent-Vernetta
authors.affiliation: Hospital Universitario Vall d́Hebron, Barcelona, España.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Sacoto
authors.affiliation: Hospital Universitario Vall d́Hebron, Barcelona, España.
authors.forename: Inés
authors.initials: I
authors.lastname: de Mir-Messa
authors.affiliation: Hospital Universitario Vall d́Hebron, Barcelona, España.
authors.forename: Sandra
authors.initials: S
authors.lastname: Rovira-Amigo
authors.affiliation: Hospital Universitario Vall d́Hebron, Barcelona, España.
authors.forename: Silvia
authors.initials: S
authors.lastname: Gartner
authors.affiliation: Hospital Universitario Vall d́Hebron, Barcelona, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Moreno-Galdó
authors.affiliation: Hospital Universitario Vall d́Hebron, Barcelona, España.
authors.forename: José Andrés
authors.initials: JA
authors.lastname: Molino-Gahete
authors.affiliation: Hospital Universitario Vall d́Hebron, Barcelona, España.
authors.forename: Felíx
authors.initials: F
authors.lastname: Castillo-Salinas
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000002:abnormalities*; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008297:Male; D012189:Retrospective Studies; D013997:Time Factors
keywords: Agenesia pulmonar; Congenital diaphragmatic hernia; Hernia diafragmática congénita; Hipoplasia pulmonar; Lung hypoplasia; Pulmonary agenesis; Pulmonary hypoplasia