title: Sperm-associated antigen 9 overexpression correlates with poor prognosis and insensitive to Taxol treatment in breast cancer.
abstract: Sperm-associated antigen 9 (SPAG9) has been reported to express in several cancers and have clinical significance. Using immunohistochemistry, we found that there was a strong association among SPAG9 expression and tumor size, TNM stage, histological grade, lymph node metastasis, and recurrence. It suggested that SPAG9-elevated expression was an independently prognostic indicator for both OS and DFS. Furthermore, the selected treatment of chemotherapy with Taxol/non-Taxol significantly affects OS and DFS. To sum up, SPAG9-elevated expression contributes to malignant behavior and poor prognosis of breast cancer and may support a potential indicator in treatment selection.
authors.affiliation: a Department of General Surgery , The Second Affiliated Hospital of Harbin Medical University , Harbin , China and.
authors.forename: Chuang
authors.initials: C
authors.lastname: Yang
authors.affiliation: a Department of General Surgery , The Second Affiliated Hospital of Harbin Medical University , Harbin , China and.
authors.forename: Bin
authors.initials: B
authors.lastname: Shen
authors.affiliation: a Department of General Surgery , The Second Affiliated Hospital of Harbin Medical University , Harbin , China and.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Zhang
authors.affiliation: b Department of Surgical Oncology , The Fourth Affiliated Hospital of Harbin Medical University , Harbin , China.
authors.forename: Qifan
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000401:mortality; D018572:Disease-Free Survival; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015999:Multivariate Analysis; D017239:Paclitaxel / Q000494:pharmacology* / Q000627:therapeutic use; D011379:Prognosis
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000972:Antineoplastic Agents, Phytogenic; D014408:Biomarkers, Tumor; C111047:SPAG9 protein, human; D017239:Paclitaxel
keywords: Breast cancer; Taxol insensitive; prognosis; sperm-associated antigen 9