title: Night-time blood pressure: a role in the prediction and prevention of diabetes?
abstract: This commentary discusses and reviews the implications of two studies published in this issue of Diabetologia by Hermida et al (DOIs: 10.1007/s00125-015-3748-8 and 10.1007/s00125-015-3749-7 ) suggesting that high nocturnal blood pressure could have a role in the prediction of diabetes and act as a therapeutic target to prevent diabetes. This overview addresses the clinical implications of this work and new research that is likely to advance this field. It also provides a framework for interpreting claims of causality from observational studies and clinical trials.
authors.affiliation: Endocrinology and Diabetes Research Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK. Martin.Rutter@manchester.ac.uk.|Manchester Diabetes Centre, 193 Hathersage Road, Manchester, UK. Martin.Rutter@manchester.ac.uk.|Manchester Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, M13 0JE, UK. Martin.Rutter@manchester.ac.uk.
authors.forename: Martin K
authors.initials: MK
authors.lastname: Rutter
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D006801:Humans; D006973:Hypertension
chemical_list: D000959:Antihypertensive Agents
keywords: Antihypertensive therapy; Chronobiology; Hypertension; Prediction; Prevention; Type 2 diabetes