title: Magnetically Controllable Polymer Nanotubes from a Cyclized Crosslinker for Site-Specific Delivery of Doxorubicin.
abstract: Externally controlled site specific drug delivery could potentially provide a means of reducing drug related side effects whilst maintaining, or perhaps increasing therapeutic efficiency. The aim of this work was to develop a nanoscale drug carrier, which could be loaded with an anti-cancer drug and be directed by an external magnetic field. Using a single, commercially available monomer and a simple one-pot reaction process, a polymer was synthesized and crosslinked within the pores of an anodized aluminum oxide template. These polymer nanotubes (PNT) could be functionalized with iron oxide nanoparticles for magnetic manipulation, without affecting the large internal pore, or inherent low toxicity. Using an external magnetic field the nanotubes could be regionally concentrated, leaving areas devoid of nanotubes. Lastly, doxorubicin could be loaded to the PNTs, causing increased toxicity towards neuroblastoma cells, rendering a platform technology now ready for adaptation with different nanoparticles, degradable pre-polymers, and various therapeutics.
authors.affiliation: Leibniz Institute of Polymer Research Dresden, Max Bergmann Centre for Biomaterials Dresden, Hohe Straße. 6, Dresden 01069, Germany.|Brain Repair Group, Schools of Biosciences, Cardiff University, Cardiff, UK.
authors.forename: Ben
authors.initials: B
authors.lastname: Newland
authors.affiliation: Institut für Chemie neuer Materialien, Universität Osnabrück, Barbarastr. 7 D-49069, Osnabrück, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Leupelt
authors.affiliation: Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Leibniz Institute of Polymer Research Dresden, Max Bergmann Centre for Biomaterials Dresden, Hohe Straße. 6, Dresden 01069, Germany.
authors.forename: Laurent S V
authors.initials: LS
authors.lastname: Thomas
authors.affiliation: Leibniz Institute of Polymer Research Dresden, Max Bergmann Centre for Biomaterials Dresden, Hohe Straße. 6, Dresden 01069, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Werner
authors.affiliation: Institut für Chemie neuer Materialien, Universität Osnabrück, Barbarastr. 7 D-49069, Osnabrück, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Steinhart
authors.affiliation: The Charles Institute of Dermatology, School of Medicine and Medical Science, University College of Dublin, Dublin, Ireland.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Wang
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism*; D002478:Cells, Cultured; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D005290:Ferric Compounds / Q000737:chemistry / Q000494:pharmacology; D060526:Magnetic Fields; D008689:Methacrylates / Q000737:chemistry / Q000494:pharmacology; D043942:Nanotubes / Q000737:chemistry*; D051381:Rats
chemical_list: D004337:Drug Carriers; D005290:Ferric Compounds; D008689:Methacrylates; C000499:ferric oxide; C004919:ethylene dimethacrylate; D004317:Doxorubicin