title: Lack of Prognostic Impact of Adjuvant Radiation on Oncologic Outcomes in Elderly Women with Breast Cancer.
abstract: BACKGROUND
  Radiotherapy plays an important role as adjuvant treatment in locally advanced breast cancer and in those patients who have undergone breast-conserving surgery. This study aimed to investigate the prognostic impact of adjuvant radiation on oncologic outcomes in elderly women with breast cancer.
  
  
  METHODS
  In this retrospective study, we reviewed and analyzed the characteristics, treatment outcome and survival of elderly women (aged ≥ 60 years) with breast cancer who were treated and followed-up between 1993 and 2014. The median follow up for the surviving patients was 38 (range 3-207) months.
  
  
  RESULTS
  One hundred and seventy-eight patients with a median age of 74 (range 60-95) years were enrolled in the study. Of the total, 60 patients received postoperative adjuvant radiation (radiation group) and the remaining 118 did not (control group). Patients in the radiation group were significantly younger than those in the control group (P value=0.004). In addition, patients in radiation group had higher node stage (P value<0.001) and disease stage (P=0.003) and tended to have higher tumor grade (P=0.031) and received more frequent (P value <0.001) adjuvant and neoadjuvant chemotherapy compared to those in the control group. There was no statistically significant difference between two groups regarding the local control, disease-free survival and overall survival rates.
  
  
  CONCLUSIONS
  In this study, we did not find a prognostic impact for adjuvant radiation on oncologic outcomes in elderly women with breast cancer.
authors.affiliation: Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran E-mail : mohpanah@gmail.com.
authors.forename: Shapour
authors.initials: S
authors.lastname: Omidvari
authors.forename: Abdolrasoul
authors.initials: A
authors.lastname: Talei
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Tahmasebi
authors.forename: Leila
authors.initials: L
authors.lastname: Moaddabshoar
authors.forename: Maliheh
authors.initials: M
authors.lastname: Dayani
authors.forename: Ahmad
authors.initials: A
authors.lastname: Mosalaei
authors.forename: Niloofar
authors.initials: N
authors.lastname: Ahmadloo
authors.forename: Mansour
authors.initials: M
authors.lastname: Ansari
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mohammadianpanah
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000401:mortality* / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome