title: Microgranular variant of acute promyelocytic leukemia with der(17) ins(17;15): A case report and review of the literature.
abstract: Acute promyelocytic leukemia (APL) with variant translocations is rare. The patient of the present case report, a 2-year-old male with a microgranular variant of APL carrying der(17) ins(17;15) translocation, exhibited fever and epistaxis. The complete blood count showed marked leukocytosis with 72% atypical promyelocytes, anemia and thrombocytopenia. Conventional cytogenetic analysis of the bone marrow cells revealed a karyotype of 47, XY, add(3)(q29), -7, ins(17;15)(q12;q14q22),+21,+mar. The promyelocytic leukemia/retinoic acid receptor α (PML/RARα) rearrangement and insertion were confirmed by fluorescencein situhybridization. The PML/RARα transcripts were not detected by the reverse transcription polymerase chain reaction, and the patient was diagnosed with microgranular variant M3 APL. The patient achieved remission after a 30-day treatment and was still in remission during a recent follow-up. The present findings suggest that the ins(17;15) variant in APL may not be associated with an unfavorable prognosis. In summary, we reported an extremely rare case of APL with der(17) ins(17;15) abnormality in a pediatric patient and reviewed the literature.
authors.affiliation: Department of Clinical Hematology, Medical College of Qingdao University, Qingdao, Shandong 266071, P.R. China.
authors.forename: Hongzai
authors.initials: H
authors.lastname: Guan
authors.affiliation: Clinical Laboratory of the Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Clinical Hematology, Medical College of Qingdao University, Qingdao, Shandong 266071, P.R. China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Clinical Hematology, Medical College of Qingdao University, Qingdao, Shandong 266071, P.R. China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Wu
authors.affiliation: Clinical Laboratory of No. 401 Hospital, PLA, Qingdao, Shandong 266071, P.R. China.
authors.forename: Huawei
authors.initials: H
authors.lastname: Yu
keywords: acute promyelocytic leukemia; chromosomal aberrations; fluorescence in situ hybridization; ins(17;15)(q12;q14q22); microgranular acute promyelocytic leukemia; prognosis