title: Vancomycin Dosing Practices, Trough Concentrations, and Predicted Area Under the Curve in Children With Suspected Invasive Staphylococcal Infections.
abstract: Recent guidelines recommend empiric vancomycin dosing of 60 mg/kg per day and consideration of higher trough concentrations (15-20 mcg/mL) in children with invasive infections. In this study, we report a retrospective review evaluating the dose/trough relationship and predicted area under the curve in pediatric patients receiving vancomycin for invasive staphylococcal infections.
authors.affiliation: Department of Clinical Pharmacy Department of Le Bonheur Children's Hospital, Memphis, Tennessee rchhim@uthsc.edu.
authors.forename: Rebecca F
authors.initials: RF
authors.lastname: Chhim
authors.affiliation: Department of Pediatrics, The University of Tennessee Health Science Center Department of Le Bonheur Children's Hospital, Memphis, Tennessee.
authors.forename: Sandra R
authors.initials: SR
authors.lastname: Arnold
authors.affiliation: Department of Clinical Pharmacy Department of Le Bonheur Children's Hospital, Memphis, Tennessee.
authors.forename: Kelley R
authors.initials: KR
authors.lastname: Lee
keywords: Area Under the Curve; Children; Methicillin-Resistant Staphylococcus aureus; Trough Concentration; Vancomycin