title: Therapy Monitoring with Functional and Molecular MR Imaging.
abstract: Cancer therapy is mainly based on different combinations of surgery, radiotherapy, and chemotherapy. Additionally, targeted therapies (designed to disrupt specific tumor hallmarks, such as angiogenesis, metabolism, proliferation, invasiveness, and immune evasion), hormonotherapy, immunotherapy, and interventional techniques have emerged as alternative oncologic treatments. Conventional imaging techniques and current response criteria do not always provide the necessary information regarding therapy success particularly to targeted therapies. In this setting, MR imaging offers an attractive combination of anatomic, physiologic, and molecular information, which may surpass these limitations, and is being increasingly used for therapy response assessment.
authors.affiliation: Department of Radiology, Complexo Hospitalario de Santiago de Compostela (CHUS), Choupana s/n, Santiago de Compostela 15706, Spain. Electronic address: roberto.garcia.figueiras@sergas.es.
authors.forename: Roberto
authors.initials: R
authors.lastname: García-Figueiras
authors.affiliation: Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Northwood, Middlesex HA6 2RN, UK.
authors.forename: Anwar R
authors.initials: AR
authors.lastname: Padhani
authors.affiliation: Department of Radiology, Complexo Hospitalario de Santiago de Compostela (CHUS), Choupana s/n, Santiago de Compostela 15706, Spain.
authors.forename: Sandra
authors.initials: S
authors.lastname: Baleato-González
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D003287:Contrast Media / Q000493:pharmacokinetics; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000639:trends*; D057054:Molecular Imaging / Q000639:trends*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000639:trends*
chemical_list: D014408:Biomarkers, Tumor; D003287:Contrast Media
keywords: Anticancer treatments; Diffusion MR imaging; Functional imaging; MR imaging; Multiparametric imaging; Oncology; Perfusion imaging/methods; Tumor response