title: Effect of Long-Term Treatment with Antioxidant SkQ1 Added to Drinking Water on Cytochromes P450 Level in Rat Liver.
abstract: Mitochondria-targeted cationic antioxidant plastoquinonyl decyltriphenylphosphonium (SkQ1) added to drinking water in therapeutic doses (250 nmol/kg per day) for a long time (up to 24 months) does not induce cytochromes P450 in rat liver.
authors.affiliation: Lomonosov Moscow State University, Faculty of Fundamental Medicine, Moscow, 119991, Russia. skulach@genebee.msu.ru.
authors.forename: K N
authors.initials: KN
authors.lastname: Myasoedova
authors.forename: D N
authors.initials: DN
authors.lastname: Silachev
mesh_terms: D000367:Age Factors; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism*; D060766:Drinking Water; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D010971:Plastoquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: C532038:10-(6'-plastoquinonyl)decyltriphenylphosphonium; D000975:Antioxidants; D060766:Drinking Water; D017382:Reactive Oxygen Species; D003577:Cytochrome P-450 Enzyme System; D010971:Plastoquinone