title: How Do Scores on the ADAS-Cog, MMSE, and CDR-SOB Correspond?
abstract: OBJECTIVE
  Clinicians and researchers who measure cognitive dysfunction often use the Alzheimer's Disease Assessment Scale--Cognitive Subscale (ADAS-Cog), the Mini-Mental State Examination (MMSE), or the Clinical Dementia Rating scale (CDR-SOB). But, the use of different measures can make it difficult to compare data across patients or studies. What is needed is a simple chart that shows how scores on these three important measures correspond to each other.
  
  
  METHODS
  Using data from 1709 participants from the Alzheimer's Disease Neuroimaging Initiative and item response theory-based statistics, we analyzed how scores on each measure, the ADAS-Cog, the MMSE, and the CDR-SOB, correspond.
  
  
  RESULTS
  Results indicated multiple inflections in CDR-SOB and ADAS-Cog scores within a given MMSE score, suggesting that the CDR-SOB and ADAS-Cog are more precise in measuring the severity of cognitive dysfunction than the MMSE.
  
  
  CONCLUSIONS
  This study shows how scores on these three popular measures of cognitive dysfunction correspond to each other, which is very useful information for both researchers and clinicians.
authors.affiliation: a Department of Psychology , Texas A & M University , College Station , TX , USA.
authors.forename: Steve
authors.initials: S
authors.lastname: Balsis
authors.affiliation: b Department of Neurology , Baylor Scott & White Health , Temple , TX , USA.
authors.forename: Jared F
authors.initials: JF
authors.lastname: Benge
authors.affiliation: a Department of Psychology , Texas A & M University , College Station , TX , USA.
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Lowe
authors.affiliation: a Department of Psychology , Texas A & M University , College Station , TX , USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Geraci
authors.affiliation: c Department of Neurology, Alzheimer's Disease and Memory Disorders Center , Baylor College of Medicine , Houston , TX , USA.
authors.forename: Rachelle S
authors.initials: RS
authors.lastname: Doody
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology*; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales
keywords: ADAS; Alzheimer’s disease; CDR; Dementia; IRT; MCI; MMSE; Neuropsychological assessment.; Psychometric