title: Chorangiocarcinoma: a case report and clinical review.
abstract: OBJECTIVE
  We describe a case of chorangiocarcinoma, a chorangioma covered by an abnormal trophoblastic proliferation, presenting in a term placenta and in an asymptomatic pregnancy. Evidence of metastasis was found on follow-up of the mother.
  
  
  METHODS
  The lesion Was diagnosed by pathologic examination after cesarian section at term for fetal macrosomia, performed because of the abnormal gross findings in the placenta. After uncomplicated delivery, a thealthy child was born and the placent was expelled completely. There was follow-up in the mother and the child, up to 19 months after delivery.
  
  
  RESULTS
  Gross examination of the placenta showed a well-demarcated and grayish yellow-white mass, bulging paracentrally from the fetal surface. Histology revealed a trophoblastic proliferation inside a chorangioma, consisting of extensive central necrosis and high mitotic activity. Immunohistochemical staining showed strong intensity for hCG, PLAP, CK, CD31 (+) and CD34 (+); Ki67 showed a high proliferation index. Follow-up revealed metastasis in the mother and chemotherapy were performed at 3 months postpartum.
  
  
  CONCLUSIONS
  This is only the sixth reported case of chorangiocarcinoma of the placenta in the literature. However, no metastasis were discovered in the reported case, which was not identical to ours. Follow-up revealed metastasis at lung in the mother. Chorangiocarcinoma should be carefully examined and followed-up.
authors.affiliation: Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital Shenzhen 518036, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Huang
authors.affiliation: Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital Shenzhen 518036, China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital Shenzhen 518036, China.
authors.forename: Dan-Fang
authors.initials: DF
authors.lastname: Yuan
authors.affiliation: Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital Shenzhen 518036, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital Shenzhen 518036, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital Shenzhen 518036, China.
authors.forename: Rui-Fang
authors.initials: RF
authors.lastname: Wu
keywords: Chorangiocarcinoma; chorangioma; choriocarcinoma; placenta; trophoblastic disease