title: Work ability in prostate cancer survivors after radical prostatectomy.
abstract: OBJECTIVE
  The aim of this study was to evaluate work ability (WA) after radical prostatectomy (RP) in prostate cancer survivors, in relation to post-RP urinary leakage (UL) and adjuvant or salvage pelvic radiation therapy (RT) and/or hormone therapy (HT).
  
  
  METHODS
  Patients for this cross-sectional study were selected from two surveys on post-RP adverse effects and WA. All participated in the workforce. Using EPIC-50/26, UL was defined as daily use of at least one pad. Data on RT were obtained from the Cancer Registry of Norway. WA, measured by the Work Ability Score (WAS), was categorized into "excellent", "good" or "moderate/poor". Multinomial logistic regression analyses assessed associations between WA and selected variables. p values below 0.05 were considered statistically significant.
  
  
  RESULTS
  Of 563 patients, 18% had received post-RP RT and/or HT. Compared to the "excellent" WAS category, such treatment was significantly associated with belonging to the "good" or "moderate/poor" category. Patients with UL (30%) were more than twice as likely to report a "moderate/poor" WAS than those without UL. Age above 65 years, less than 3 years since RP and co-morbidity were additional factors associated with increased risk of reporting a lower WAS. Half of the patients rated their current WA as "very good" with respect to the physical or mental demands of their work.
  
  
  CONCLUSIONS
  Increasing age, UL, co-morbidity and time since RP are associated with decreasing post-RP WA. Without specifying the individual therapy, post-RP oncological treatment seems to have an additional negative effect, warranting consideration of patients' work plans when considering post-RP oncological treatment.
authors.affiliation: a National Resource Center for Late Effects After Cancer Treatment, Oslo University Hospital, The Norwegian Radium Hospital , Oslo , Norway.
authors.forename: Sigrun
authors.initials: S
authors.lastname: Dahl
authors.affiliation: a National Resource Center for Late Effects After Cancer Treatment, Oslo University Hospital, The Norwegian Radium Hospital , Oslo , Norway.|b Faculty of Medicine , University of Oslo , Oslo , Norway.
authors.forename: Milada
authors.initials: M
authors.lastname: Cvancarova
authors.affiliation: a National Resource Center for Late Effects After Cancer Treatment, Oslo University Hospital, The Norwegian Radium Hospital , Oslo , Norway.|b Faculty of Medicine , University of Oslo , Oslo , Norway.
authors.forename: Alv A
authors.initials: AA
authors.lastname: Dahl
authors.affiliation: a National Resource Center for Late Effects After Cancer Treatment, Oslo University Hospital, The Norwegian Radium Hospital , Oslo , Norway.|b Faculty of Medicine , University of Oslo , Oslo , Norway.
authors.forename: Sophie D
authors.initials: SD
authors.lastname: Fosså
mesh_terms: D000367:Age Factors; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D015897:Comorbidity; D003430:Cross-Sectional Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009664:Norway; D011183:Postoperative Complications / Q000453:epidemiology*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000628:therapy*; D018714:Radiotherapy, Adjuvant; D062707:Return to Work; D016879:Salvage Therapy; D011795:Surveys and Questionnaires; D013997:Time Factors; D014549:Urinary Incontinence / Q000453:epidemiology*; D014938:Work Capacity Evaluation
chemical_list: D018931:Antineoplastic Agents, Hormonal
keywords: Adjuvant/salvage treatment; adverse effects; prostate cancer; radical prostatectomy; work ability