title: Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma.
abstract: Feline mammary carcinomas are characterized by rapid progression and metastases. Vascular endothelial growth factor (VEGF) is a key regulator of tumor angiogenesis, proliferation and metastasis. The present study aimed to investigate the effects of a single drug therapy of bevacizumab on a xenograft model of feline mammary carcinoma expressing VEGF protein. Bevacizumab treatment suppressed tumor growth by inhibiting angiogenesis and enhancing apoptosis; however, it did not affect the tumor proliferation index. Thus, bevacizumab had anti-tumor effects on a xenograft model, and this may be useful for the treatment of feline mammary carcinoma.
authors.affiliation: Department of Veterinary Pathology, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Michishita
authors.forename: Aya
authors.initials: A
authors.lastname: Ohtsuka
authors.forename: Rei
authors.initials: R
authors.lastname: Nakahira
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tajima
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Nobuo
authors.initials: N
authors.lastname: Sasaki
authors.forename: Toshiro
authors.initials: T
authors.lastname: Arai
authors.forename: Kimimasa
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000818:Animals; D000068258:Bevacizumab / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy* / Q000378:metabolism; D002415:Cats; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D008297:Male; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D016688:Mice, Inbred NOD; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays
chemical_list: D020533:Angiogenesis Inhibitors; D042442:Vascular Endothelial Growth Factors; D000068258:Bevacizumab; D040262:Receptors, Vascular Endothelial Growth Factor