title: Statins and atherosclerosis: the role of epigenetics.
abstract: Atherosclerosis is an immune-inflammatory disease, in which pathophysiological mechanisms include inflammation patterns and epigenetic changes that alter gene expression of several inflammatory and non-inflammatory mediators. Epigenetics is offering explanations on how diet, environmental factors and lifestyle can influence the onset and progression of the disease, and how these alterations can be transmitted to the following generations without any changes in DNA sequences. Statins, through their pleiotropic effects, provide a useful tool in controlling the progression of plaques and their subsequent impact.
authors.affiliation: SServicio de Medicina Interna, Hospital Dr. Miguel Pérez Carreño, IVSS, Caracas, Venezuela. Clínica Fénix Salud, Caracas, Venezuela. Address: Edificio Loma Escondida, Piso 8, Apartamento 87, Urbanización Lomas del Ávila, Palo Verde, Municipio Sucre, Estado Miranda CP 1070, Venezuela. Email: storino1974@gmail.com.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Storino Farina
authors.affiliation: Servicio de Medicina Interna, Hospital Dr. Miguel Pérez Carreño, IVSS, Caracas, Venezuela.
authors.forename: Jairo
authors.initials: J
authors.lastname: Rojano Rada
authors.affiliation: Servicio de Medicina Interna, Hospital Dr. Miguel Pérez Carreño, IVSS, Caracas, Venezuela.
authors.forename: Antony
authors.initials: A
authors.lastname: Molina Garrido
authors.affiliation: Servicio de Medicina Interna, Hospital Dr. Miguel Pérez Carreño, IVSS, Caracas, Venezuela.
authors.forename: Xiomara
authors.initials: X
authors.lastname: Martínez
authors.affiliation: Servicio de Medicina Interna, Hospital Dr. Miguel Pérez Carreño, IVSS, Caracas, Venezuela.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Pulgar
authors.affiliation: Servicio de Medicina Interna, Hospital Dr. Miguel Pérez Carreño, IVSS, Caracas, Venezuela.
authors.forename: Roxanna
authors.initials: R
authors.lastname: Paniagua
authors.affiliation: Servicio de Medicina Interna, Hospital Dr. Miguel Pérez Carreño, IVSS, Caracas, Venezuela.
authors.forename: Jorge
authors.initials: J
authors.lastname: Garrido
mesh_terms: D050197:Atherosclerosis / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D001483:Base Sequence; D018450:Disease Progression; D044127:Epigenesis, Genetic; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D058226:Plaque, Atherosclerotic / Q000188:drug therapy / Q000473:pathology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: atherosclerosis; cytokines; epigenetics; immunomodulation; statins