title: Large doses of uterotonic drugs caused type II second degree sinoatrial block during cesarean section.
abstract: In China, it is a routine procedure to inject 250 μg of hemabate (sterile solution, an oxytocic, contains the tromethamine salt of the (I5S)-15 methyl analogue of naturally occurring prostaglandin F2α in a solution suitable for intramuscular injection) into the myometrium of patients experiencing uterine inertia after delivery, with an additional dose given in the event that the efficacy is not obvious. Although hemabate is prohibited from being used in patients with active liver disease, there are no restrictions regarding the application of hemabate in positive hepatitis B surface antigen (HbsAg)-positive subjects with normal liver function. Here we report adverse effects of hemabate in 1 HbsAg-positive subject with normal liver function. This subject experienced increased blood pressure, chest tightness, and type II second degree sinoatrial block 25 minutes after an additional injection of hemabate. Thus, special attention should be paid when applying hemabate in HbsAgpositive subjects with normal liver function.
authors.forename: Zhe-Feng
authors.initials: ZF
authors.lastname: Quan
authors.forename: Ming
authors.initials: M
authors.lastname: Tian
authors.forename: Ping
authors.initials: P
authors.lastname: Chi
mesh_terms: D000328:Adult; D002260:Carboprost / Q000009:adverse effects*; D002585:Cesarean Section; D004338:Drug Combinations; D005260:Female; D006801:Humans; D010120:Oxytocics / Q000009:adverse effects*; D011247:Pregnancy; D012848:Sinoatrial Block / Q000139:chemically induced*; D014325:Tromethamine / Q000009:adverse effects*
chemical_list: D004338:Drug Combinations; D010120:Oxytocics; D014325:Tromethamine; D002260:Carboprost; C062843:carboprost tromethamine