title: Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes.
abstract: Steroidal compounds exhibit particular physiological activities. In this paper, some steroidal thiosemicarbazones platinum (Pt(II)) complexes were synthesized by the condensation of steroidal ketones with thiosemicarbazide using estrone, chenodeoxycholic acid, and 7-deoxycholic acid as starting materials and complexation of steroidal thiosesemicarbazones with Pt(II). The complexes were characterized by IR, NMR, and MS, and their antiproliferative activities were evaluated. The results showed that some steroidal thiosemicarbazones platinum (Pt(II)) complexes displayed moderate cytotoxicity to HeLa and Bel-7404 cells. Thereinto, complex 6 showed an excellent inhibited selectivity to HeLa cells with an IC50 value of 9.2 μM and SI value of 21.7. At the same time, all compounds were almost inactive to HEK293T (normal kidney epithelial cells). The information obtained from the studies may be useful for the design of novel chemotherapeutic drugs.
authors.affiliation: College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China.
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Huang
authors.affiliation: College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China.
authors.forename: Erbin
authors.initials: E
authors.lastname: Kong
authors.affiliation: College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Gan
authors.affiliation: College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Guangxi Colleges and University Key Laboratory of Beibu Gulf Oil and Natural Gas Resource Effective Utilization, Qizhou University, Qizhou 535000, China.
authors.forename: Qifu
authors.initials: Q
authors.lastname: Lin
authors.affiliation: College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China ; Guangxi Colleges and University Key Laboratory of Beibu Gulf Oil and Natural Gas Resource Effective Utilization, Qizhou University, Qizhou 535000, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Cui