title: Increased Peroxiredoxin 6 Expression Predicts Biochemical Recurrence in Prostate Cancer Patients After Radical Prostatectomy.
abstract: OBJECTIVE
  Elevated levels of oxidative stress biomarkers have been shown to associate with more aggressive behavior in malignancies. The aim of the present study was to determine the relationship between the expression of peroxiredoxins (Prx) and sulfiredoxin (Srx) in localized prostate cancer (PC) with clinicopathological parameters and outcome after radical prostatectomy (RP).
  
  
  METHODS
  Samples of 240 RP patients were analyzed for Prx1, 2, 5 and 6 and Srx expression by immunohistochemistry and the results were correlated with clinicopathological data, biochemical recurrence-free survival (BFS), prostate cancer-specific survival (PCS) and overall survival (OS).
  
  
  RESULTS
  Augmented Prx2 and Prx6 expression was associated with several conventional prognostic factors. Increased Prx2 and Prx6 expression predicted for shortened BFS (p=0.027 and p=0.020) and worse OS (p=0.045 and p=0.033). In the multivariate analysis, Prx6 expression was an independent predictor of BFS (p=0.030).
  
  
  CONCLUSIONS
  Elevated Prx6 expression associates with a worse prognosis after RP for clinically localized PC.
authors.affiliation: Department of Surgery, Kuopio University Hospital, Kuopio, Finland Department of Surgery, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, Kuopio, Finland sami.raatikainen@kuh.fi.
authors.forename: Sami
authors.initials: S
authors.lastname: Raatikainen
authors.affiliation: Department of Surgery, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Sirpa
authors.initials: S
authors.lastname: Aaaltomaa
authors.affiliation: Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Vesa
authors.initials: V
authors.lastname: Kärjä
authors.affiliation: Department of Pathology and Forensic Medicine, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, Cancer Center of Eastern Finland, Kuopio, Finland.
authors.forename: Ylermi
authors.initials: Y
authors.lastname: Soini
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D054465:Peroxiredoxin VI / Q000378:metabolism*; D011379:Prognosis; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000737:chemistry* / Q000473:pathology* / Q000601:surgery; D017382:Reactive Oxygen Species
chemical_list: D017382:Reactive Oxygen Species; D054465:Peroxiredoxin VI
keywords: Peroxiredoxin; prognosis; prostate cancer; radical prostatectomy; sulfiredoxin