title: MUM-1 expression differentiates AITL with HRS-like cells from cHL.
abstract: MUM1 is a member of the interferon regulatory factor family of transcription factors. It is normally expressed in plasma cells, late B cells, and activated T cells, and has been described in several B-cell malignancies and some T-cell neoplasms. The aim of our study was to evaluate the role of MUM-1/IRF4 protein in differentiating angioimmunoblastic T cell lymphoma (AITL) with Hodgkin/Reed-Sternberg (HRS)-like cells from cHL. We identified 12 cases of AITL with HRS-like cells and 24 cases of cHL from March 2013 to November 2014. IHC for MUM-1/IRF4 protein was performed on the tissue of these cases and some relevant positive and negative controls. MUM-1 was expressed in HRS-like cells and some neoplastic T-cells in AITL with HRS-like cells (12/12, 100%) and formed the rosettes around the HRS-like cells (12/12, 100%), expressed in HRS cells in classic Hodgkin Lymphoma (cHL) (24/24, 100%) and just one case formed rosettes around the HRS cells (1/24, 4.2%). Based on the results, MUM-1 could be a useful marker for the differential diagnosis between AITL with HRS-like cells and cHL.
authors.affiliation: Department of Pathology, Beijing Friendship Hospital of Capital Medical University Beijing 100050, China ; Department of Pathology, The First Affiliated Hospital of Jiujiang University Jiujiang, China.
authors.forename: Wenyong
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Pathology, Beijing Friendship Hospital of Capital Medical University Beijing 100050, China.
authors.forename: Jianlan
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Jiujiang University Jiujiang, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Dalin Medical University Dalin, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Pathology, Shanghai Pudong Hospital of Fudan University Shanghai, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
authors.affiliation: Department of Pathology, Beijing Friendship Hospital of Capital Medical University Beijing 100050, China.
authors.forename: Xiaoge
authors.initials: X
authors.lastname: Zhou
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D003937:Diagnosis, Differential; D004854:Herpesvirus 4, Human / Q000235:genetics; D006689:Hodgkin Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D050835:Interferon Regulatory Factors / Q000032:analysis*; D016399:Lymphoma, T-Cell / Q000737:chemistry* / Q000235:genetics / Q000473:pathology / Q000821:virology; D011237:Predictive Value of Tests; D012367:RNA, Viral / Q000235:genetics; D016539:Reed-Sternberg Cells / Q000737:chemistry* / Q000473:pathology / Q000821:virology; D012189:Retrospective Studies; D000099218:Interferon Regulatory Factor-4
chemical_list: D014408:Biomarkers, Tumor; D050835:Interferon Regulatory Factors; D012367:RNA, Viral; D000099218:Interferon Regulatory Factor-4
keywords: AITL with HRS-like cells; MUM-1; cHL; differential diagnosis; immunohistochemistry