title: Plasma C1q/TNF-related protein 9: a promising biomarker for diabetic renal vascular injury.
abstract: BACKGROUND
  Adipocytokines are associated with the pathophysiology of type 2 diabetes (T2DM).
  
  
  METHODS
  We analyzed the relationship between levels of the plasma C1q/tumor necrosis factor-related protein 9 (CTRP9) and other adipocytokines or the endothelial function in patients with T2DM, and analyzed their trending manner.
  
  
  RESULTS
  CTRP9 was detected in plasma from 14 out of a total of 28 patients. The values were not normally distributed. In comparing between groups in which CTRP9 was or was not detected, there were statistically significant differences in the high molecular weight adiponectin (HAN) and the urinary albumin/creatinine ratio (ACR). This indicates that both CTRP9 and HAN reflect the pathophysiology of renal involvement in T2DM. HAN correlated with Body Mass Index, ACR, and homeostasis model assessment of insulin resistance. However, CTRP9 did not correlate with HAN or any other parameters.
  
  
  CONCLUSIONS
  CTRP9 independently trends in a different manner from HAN, and may reflect diabetic renal vascular risk in association with atherosclerosis and abnormal glucose metabolism besides of impaired vaso-relaxation in patients with T2DM.
authors.affiliation: Department of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan - tfujita@med.nihon-u.ac.jp.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Fujita
authors.affiliation: Department of Internal Medicine, Sakuboukai Tokiwadaigeka Hospital, Tokyo, Japan.
authors.forename: Hidetsuna
authors.initials: H
authors.lastname: Watanabe
authors.affiliation: Department of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Murata
authors.affiliation: Department of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Hemmi
authors.affiliation: Department of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Minako
authors.initials: M
authors.lastname: Yabuki
authors.affiliation: Department of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Fuke
authors.affiliation: Department of Laboratory Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Satomura
authors.affiliation: Department of General Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Soma
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003925:Diabetic Angiopathies / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood*; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008297:Male; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
chemical_list: D052242:Adiponectin; D015415:Biomarkers; C543615:C1QTNF9B protein, human; D006023:Glycoproteins; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins