title: Hepatitis C virus: A global view.
abstract: Hepatitis C virus (HCV) is a global challenge; 130-175 million are chronically infected. Over 350000 die each year from HCV. Chronic HCV is the primary cause of cirrhosis, hepatocellular carcinoma (HCC), and end-stage liver disease. Management of chronic HCV is aimed at preventing cirrhosis, reducing the risk of HCC, and treating extra hepatic complications. New treatments for chronic HCV has been devoted based on direct-acting antivirals, as pegylated interferon (peginterferon) is responsible for many side effects and limits treatment access. Sofosbuvir is the first compound to enter the market with Peginterferon-free combination regimens.
authors.affiliation: Amal Ahmed Mohamed, Biochemistry Department, National Hepatology and Tropical Medicine Institute, Cairo 11796, Egypt.
authors.forename: Amal Ahmed
authors.initials: AA
authors.lastname: Mohamed
authors.affiliation: Amal Ahmed Mohamed, Biochemistry Department, National Hepatology and Tropical Medicine Institute, Cairo 11796, Egypt.
authors.forename: Tamer A
authors.initials: TA
authors.lastname: Elbedewy
authors.affiliation: Amal Ahmed Mohamed, Biochemistry Department, National Hepatology and Tropical Medicine Institute, Cairo 11796, Egypt.
authors.forename: Magdy
authors.initials: M
authors.lastname: El-Serafy
authors.affiliation: Amal Ahmed Mohamed, Biochemistry Department, National Hepatology and Tropical Medicine Institute, Cairo 11796, Egypt.
authors.forename: Naglaa
authors.initials: N
authors.lastname: El-Toukhy
authors.affiliation: Amal Ahmed Mohamed, Biochemistry Department, National Hepatology and Tropical Medicine Institute, Cairo 11796, Egypt.
authors.forename: Wesam
authors.initials: W
authors.lastname: Ahmed
authors.affiliation: Amal Ahmed Mohamed, Biochemistry Department, National Hepatology and Tropical Medicine Institute, Cairo 11796, Egypt.
authors.forename: Zaniab
authors.initials: Z
authors.lastname: Ali El Din
keywords: Direct-acting antivirals; Hepatitis C; Peginterferon; Sofosbuvir