title: MR T1ρ and T2 of meniscus after acute anterior cruciate ligament injuries.
abstract: OBJECTIVE
  To evaluate differences in meniscal T1ρ and T2 quantification in patients with acute anterior cruciate ligament (ACL) injuries and to determine correlations of these differences with MR morphological grading and patient-reported outcomes.
  
  
  METHODS
  Bilateral knees of 52 patients with acute ACL injury and 20 healthy controls were scanned using 3 T magnetic resonance imaging (MRI) T1ρ and T2 mapping in this prospective study. Quantitative analysis of the meniscus was performed in anterior and posterior horns of the lateral and medial menisci. Morphological meniscal damage was assessed using modified whole-organ MRI scores (WORMS). Measurements were compared between injured, uninjured contralateral, and control knees using a mixed-effects regression model. Correlations between meniscal T1ρ/T2, WORMS and Knee Injury and Osteoarthritis Outcome Scores (KOOS) were examined using partial correlation analysis.
  
  
  RESULTS
  Mean meniscal T1ρ and T2 values were significantly higher in ACL-injured knees compared to control and contralateral knees. Menisci of ACL-injured knees without tears, including those limited to modified meniscal WORMS grade 0, also had significantly higher T1ρ and T2 values compared to menisci of uninjured knees. Within ACL-injured knees, T1ρ and T2 values showed significant positive associations with meniscal WORMS and significant negative associations with KOOS.
  
  
  CONCLUSIONS
  Acute ACL injuries are associated with significantly increased meniscal T1ρ and T2 values in both patients with and without meniscal lesions or tears, suggesting quantitative MRI provides more sensitive measures of meniscal differences compared to traditional morphological MRI sequences. Correlation between meniscal T1ρ/T2 and KOOS suggest that quantitative MRI is reflective of the extent of patients' clinical symptoms.
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, United States. Electronic address: amy.w@berkeley.edu.
authors.forename: Amy
authors.initials: A
authors.lastname: Wang
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, United States. Electronic address: Valentina.Pedoia@ucsf.edu.
authors.forename: Valentina
authors.initials: V
authors.lastname: Pedoia
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, United States. Electronic address: favian.su@pitt.edu.
authors.forename: Favian
authors.initials: F
authors.lastname: Su
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, United States. Electronic address: elijahabramson@gmail.com.
authors.forename: Elijah
authors.initials: E
authors.lastname: Abramson
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, United States. Electronic address: Martin.Kretzschmar@ucsf.edu.
authors.forename: Martin
authors.initials: M
authors.lastname: Kretzschmar
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, United States. Electronic address: Lorenzo.Nardo@ucsf.edu.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Nardo
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, United States. Electronic address: Thomas.Link@ucsf.edu.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Link
authors.affiliation: Department of Epidemiology and Biostatistics, University of California, San Francisco, United States. Electronic address: Charles.McCulloch@ucsf.edu.
authors.forename: Charles E
authors.initials: CE
authors.lastname: McCulloch
authors.affiliation: Department of Epidemiology and Biostatistics, University of California, San Francisco, United States. Electronic address: CJin@psf.ucsf.edu.
authors.forename: Chengshi
authors.initials: C
authors.lastname: Jin
authors.affiliation: Department of Orthopaedic Surgery, University of California, San Francisco, United States. Electronic address: MaBen@ucsf.edu.
authors.forename: C Benjamin
authors.initials: CB
authors.lastname: Ma
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, United States. Electronic address: Xiaojuan.Li@ucsf.edu.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Li
mesh_terms: D000203:Activities of Daily Living; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000070598:Anterior Cruciate Ligament Injuries / Q000000981:diagnostic imaging* / Q000534:rehabilitation; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008592:Menisci, Tibial / Q000000981:diagnostic imaging*; D008875:Middle Aged; D011788:Quality of Life; D000070600:Tibial Meniscus Injuries / Q000000981:diagnostic imaging; D015599:Trauma Severity Indices; D055815:Young Adult
keywords: Anterior cruciate ligament; Magnetic resonance imaging; Meniscus; Osteoarthritis; T1ρ; T2