title: Forty-five years of cell-cycle genetics.
abstract: In the early 1970s, studies in Leland Hartwell's laboratory at the University of Washington launched the genetic analysis of the eukaryotic cell cycle and set the path that has led to our modern understanding of this centrally important process. This 45th-anniversary Retrospective reviews the steps by which the project took shape, the atmosphere in which this happened, and the possible morals for modern times. It also provides an up-to-date look at the 35 original CDC genes and their human homologues.
authors.affiliation: Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109 Departments of Genome Sciences and Medicine, University of Washington, Seattle, WA 98195.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Reid
authors.affiliation: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1X5, Canada.
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Culotti
authors.affiliation: Saccharomyces Genome Database, Stanford University School of Medicine, Stanford, CA 94305 Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Nash
authors.affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 jpringle@stanford.edu.
authors.forename: John R
authors.initials: JR
authors.lastname: Pringle
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D005057:Eukaryotic Cells / Q000166:cytology / Q000502:physiology; D018816:Genes, cdc; D006801:Humans