title: Current Understandings of Molecular Biology of Echinococcus multilocularis, a Pathogen for Alveolar Echinococcosis in Humans- a Narrative Review Article.
abstract: BACKGROUND
  Echinococcus multilocularis is a tiny tapeworm, responsible for 0.3~0.5 million alveolar echinococcosis in humans.
  
  
  METHODS
  We searched relevant papers published between 1981 and 2013 based on the database sources such as PubMed and Google scholar, and collected and integrated the data for analysis.
  
  
  RESULTS
  The parasite is able to use host-originated molecules to modulate its development and has complex signalling pathways than expected previously. E. multilocularis utilizes many types of alternative splicing approaches to generate transcript isoforms. Recently, the genome of E. multilocularis has been deciphered.
  
  
  CONCLUSIONS
  These data will give us a profound understanding of biology of E. multilocularis, which will promote the use as a model to study helminths.
authors.affiliation: College of Chemistry and Bioengineering, Lanzhou Jiaotong University, Lanzhou, P.R. China.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Life Science and Technology, Xinjiang University, Urumqi, P.R. China.
authors.forename: Juntao
authors.initials: J
authors.lastname: Ding
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu, China.
authors.forename: Xiaola
authors.initials: X
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu, China.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Zheng
keywords: Alternative splicing; Echinococcus multilocularis; Signalling pathway