title: miR-429 mediates δ-tocotrienol-induced apoptosis in triple-negative breast cancer cells by targeting XIAP.
abstract: Vitamin E δ-tocotrienol has been reported to possess anticancer activity both in vitro and in vivo. However, the underlying molecular mechanisms of δ-tocotrienol induced apoptosis in triple-negative breast cancer are not fully understood. Here, we reported that microRNA-429 (miR-429) is up-regulated in two TNBC cell lines (MDA-MB-231 and MDA-MB-468), treated with δ-tocotrienol. Inhibition of miR-429 may partially rescue the apoptosis induced by δ-tocotrienol in MDA-MB-231 cells. We also showed that the forced expression of miR-429 was sufficient to lead to apoptosis in MDA-MB-231 cells. Furthermore, we identified X-linked inhibitor of apoptosis protein (XIAP) as one of miR-429's target genes. These results suggest that the activation of miR-429 by δ-tocotrienol may be an effective approach for the prevention and treatment of triple-negative breast cancer.
authors.affiliation: Department of Breast Oncology; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer Tianjin 300060, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Tianjin Eye Hospital Tianjin 300020, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ju
authors.affiliation: Department of Immunology, Affiliated Hospital of Chinese People's Armed Police Forces Logistics Institute Tianjin 300100, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Shen
authors.affiliation: Department of Breast Oncology; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer Tianjin 300060, China.
authors.forename: Zhongsheng
authors.initials: Z
authors.lastname: Tong
keywords: X-linked inhibitor of apoptosis protein (XIAP); apoptosis; microRNA-429 (miR-429); triple-negative breast cancer (TNBC); δ-Tocotrienol