title: New Insights on the Maternal Diet Induced-Hypertension: Potential Role of the Phenotypic Plasticity and Sympathetic-Respiratory Overactivity.
abstract: Systemic arterial hypertension (SAH) is an important risk factor for cardiovascular disease and affects worldwide population. Current environment including life style coupled with genetic programming have been attributed to the rising incidence of hypertension. Besides, environmental conditions during perinatal development such as maternal malnutrition can program changes in the integration among renal, neural, and endocrine system leading to hypertension. This phenomenon is termed phenotypic plasticity and refers to the adjustment of a phenotype in response to environmental stimuli without genetic change, following a novel or unusual input during development. Human and animal studies indicate that fetal exposure to an adverse maternal environment may alter the renal morphology and physiology that contribute to the development of hypertension. Recently, it has been shown that the maternal protein restriction alter the central control of SAH by a mechanism that include respiratory dysfunction and enhanced sympathetic-respiratory coupling at early life, which may contribute to adult hypertension. This review will address the new insights on the maternal diet induced-hypertension that include the potential role of the phenotypic plasticity, specifically the perinatal protein malnutrition, and sympathetic-respiratory overactivity.
authors.affiliation: Department of Physical Education and Sport Science, Academic Center of Vitoria, Federal University of Pernambuco Vitória de Santo Antão, Brazil.
authors.forename: João H
authors.initials: JH
authors.lastname: Costa-Silva
authors.affiliation: Department of Physical Education and Sport Science, Academic Center of Vitoria, Federal University of Pernambuco Vitória de Santo Antão, Brazil.
authors.forename: José L
authors.initials: JL
authors.lastname: de Brito-Alves
authors.affiliation: Department of Physical Education and Sport Science, Academic Center of Vitoria, Federal University of Pernambuco Vitória de Santo Antão, Brazil.
authors.forename: Monique Assis de V
authors.initials: MA
authors.lastname: Barros
authors.affiliation: Department of Physical Education and Sport Science, Academic Center of Vitoria, Federal University of Pernambuco Vitória de Santo Antão, Brazil.
authors.forename: Viviane Oliveira
authors.initials: VO
authors.lastname: Nogueira
authors.affiliation: Department of Physical Education and Sport Science, Academic Center of Vitoria, Federal University of Pernambuco Vitória de Santo Antão, Brazil.
authors.forename: Kássya M
authors.initials: KM
authors.lastname: Paulino-Silva
authors.affiliation: Department of Physical Education and Sport Science, Academic Center of Vitoria, Federal University of Pernambuco Vitória de Santo Antão, Brazil.
authors.forename: Allan
authors.initials: A
authors.lastname: de Oliveira-Lira
authors.affiliation: Department of Physical Education and Sport Science, Academic Center of Vitoria, Federal University of Pernambuco Vitória de Santo Antão, Brazil.
authors.forename: Isabele G
authors.initials: IG
authors.lastname: Nobre
authors.affiliation: Department of Physical Education and Sport Science, Academic Center of Vitoria, Federal University of Pernambuco Vitória de Santo Antão, Brazil.
authors.forename: Jéssica
authors.initials: J
authors.lastname: Fragoso
authors.affiliation: Department of Physical Education and Sport Science, Academic Center of Vitoria, Federal University of Pernambuco Vitória de Santo Antão, Brazil.
authors.forename: Carol G
authors.initials: CG
authors.lastname: Leandro
keywords: developmental plasticity; hypertension; perinatal nutrition; protein restriction; respiratory control