title: Lifestyle and Sporadic Colorectal Cancer in India.
abstract: BACKGROUND
  The study evaluated the patient, lifestyle and tumor profile in patients undergoing upfront surgery for sporadic colorectal cancer (CRC) in Indian population.
  
  
  METHODS
  One hundred consecutive patients were included. Details related to their demographic profile, habits, signs and symptoms, tumor profile, further treatment and follow up were recorded.
  
  
  RESULTS
  The majority of the patients had colonic cancer (68%), advanced tumor stage 3 and 4 (46%), moderately differentiated tumors (70%) with absence of lymphatic invasion (60%) and metastasis (90%). Correlations between tumor location and abdominal pain (p-value 0.002), bleeding per rectum (p-value <0.001), difficulty in micturition (p-value 0.012) and constipation (p-value 0.007) were found to be statistically significant. Abdominal pain was more frequently reported in patients with metastasis (p-value 0.031). Loss of weight statistically correlated with absence of lymphatic invasion (p-value 0.047). Associations between tumor stage and alcohol intake (p-value 0.050) and non vegetarian diet (p-value 0.006); lymphatic invasion and intake of spicy food (p-value 0.040) and non vegetarian diet (p-value 0.001) and metastasis and alcohol intake (p-value 0.041) were also observed. Age and tumor grade were also correlated (p-value 0.020).
  
  
  CONCLUSIONS
  Minimizing the adverse lifestyle factors can help in reducing the overall incidence of CRC in the Indian population.
authors.affiliation: Department of Research, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India E-mail : mausumi02@yahoo.com; bharadwajm@icmr.org.in; dcdoval@gmail.com.
authors.forename: Rupal
authors.initials: R
authors.lastname: Sinha
authors.forename: Dinesh Chandra
authors.initials: DC
authors.lastname: Doval
authors.forename: Showket
authors.initials: S
authors.lastname: Hussain
authors.forename: Kapil
authors.initials: K
authors.lastname: Kumar
authors.forename: Shivendra
authors.initials: S
authors.lastname: Singh
authors.forename: Seemi Farhat
authors.initials: SF
authors.lastname: Basir
authors.forename: Mausumi
authors.initials: M
authors.lastname: Bharadwaj
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000473:pathology* / Q000601:surgery; D000367:Age Factors; D000428:Alcohol Drinking; D014408:Biomarkers, Tumor; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000601:surgery; D014676:Diet, Vegetarian; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008019:Life Style; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor