title: Molecularly imprinted polymer doped with Hectorite for selective recognition of sinomenine hydrochloride.
abstract: In this work, a new and facile method was introduced to prepare molecularly imprinted polymers (MIPs) based on nano clay hectorite (Hec) for sinomenine hydrochloride (SM) analysis. Hec was firstly dissolved in distilled water in order to swell adequately, followed by a common precipitation polymerization with SM as the template, methacrylic acid as monomer, ethylene glycol dimethacrylate as a crosslinker and 2,2-azobisisobutyronitrile as an initiator. Hec@SM-MIPs were characterized by Fourier transform infrared spectrometer, transmission electron microscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy and X-ray diffraction. The maximum binding capacity of Hec@SM-MIPs, SM-MIPs and non-imprinted polymers (NIPs) (Hec@NIPs) was 57.4, 16.8 and 11.6 mg/g, respectively. The reason for this result may be that Hec@SM-MIPs have more binding sites and imprinted cavities for template molecule. Equilibrium data were described by the Langmuir and Freundlich isotherm models. The results showed that the Hec@SM-MIPs adsorption data correlated better with the Langmuir equation than the Freundlich equation under the studied concentration range. In vitro drug release experiment, Hec@SM-MIPs have a better ability to control SM release than SM-MIPs. Therefore, Hec@SM-MIPs were successfully applied to extraction of SM and used as the materials for drug delivery system.
authors.affiliation: a Tianjin Municipal Key Lab of Modification and Functional Fibers, School of Materials Science and Engineering , Tianjin Polytechnic University , Tianjin , China.
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.affiliation: a Tianjin Municipal Key Lab of Modification and Functional Fibers, School of Materials Science and Engineering , Tianjin Polytechnic University , Tianjin , China.
authors.forename: H L
authors.initials: HL
authors.lastname: Fu
authors.affiliation: a Tianjin Municipal Key Lab of Modification and Functional Fibers, School of Materials Science and Engineering , Tianjin Polytechnic University , Tianjin , China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Li
authors.affiliation: a Tianjin Municipal Key Lab of Modification and Functional Fibers, School of Materials Science and Engineering , Tianjin Polytechnic University , Tianjin , China.
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.affiliation: a Tianjin Municipal Key Lab of Modification and Functional Fibers, School of Materials Science and Engineering , Tianjin Polytechnic University , Tianjin , China.
authors.forename: N
authors.initials: N
authors.lastname: Wang
authors.affiliation: a Tianjin Municipal Key Lab of Modification and Functional Fibers, School of Materials Science and Engineering , Tianjin Polytechnic University , Tianjin , China.
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.affiliation: a Tianjin Municipal Key Lab of Modification and Functional Fibers, School of Materials Science and Engineering , Tianjin Polytechnic University , Tianjin , China.
authors.forename: X X
authors.initials: XX
authors.lastname: Zhang
mesh_terms: D000327:Adsorption; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D065546:Drug Liberation; D007700:Kinetics; D054802:Molecular Imprinting; D009019:Morphinans / Q000737:chemistry*; D058105:Polymerization; D011109:Polymethacrylic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D017640:Silicates / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D009019:Morphinans; D011109:Polymethacrylic Acids; D017640:Silicates; C013547:hectorite; C030613:polymethacrylic acid; C009271:sinomenine
keywords: Molecularly imprinted polymers; controlled release; drug delivery system; hectorite; sinomenine hydrochloride