title: Allergen Immunotherapy Outcomes and Unmet Needs: A Critical Review.
abstract: Allergen immunotherapy (AIT) has been evaluated throughout several studies over the last years. A position paper from the European Academy of Allergy and Clinical Immunology highlighted the total combined symptoms score as the method to record the primary end point in AIT studies for allergic rhinitis, but this score still needs to be formally validated and more work done for other allergic diseases. These aspects still seem to be the main unmet need in the evaluation of AIT clinical outcomes in clinical trials.
authors.affiliation: Division of Allergy, Department of Pulmonology, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, 371, av. du Doyen Gaston Giraud - 34295, Montpellier cedex 5, France; MACVIA-LR, European Innovation Partnership on Active and Healthy Ageing Reference Site, University Hospital of Montpellier, 371, av. du Doyen Gaston Giraud - 34295, Montpellier cedex 5, France.
authors.forename: Davide
authors.initials: D
authors.lastname: Caimmi
authors.affiliation: Section of Allergy and Clinical Immunology, Imperial College London, National Heart & Lung Institute, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.
authors.forename: Moises A
authors.initials: MA
authors.lastname: Calderon
authors.affiliation: MACVIA-LR, European Innovation Partnership on Active and Healthy Ageing Reference Site, University Hospital of Montpellier, 371, av. du Doyen Gaston Giraud - 34295, Montpellier cedex 5, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Bousquet
authors.affiliation: Division of Allergy, Department of Pulmonology, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, 371, av. du Doyen Gaston Giraud - 34295, Montpellier cedex 5, France; Sorbonne Universités, UPMC Paris 06, UMR-S 1136, IPLESP, Equipe EPAR, F-75013, 4, Place Jussieu - 75005 Paris, France. Electronic address: pascal.demoly@inserm.fr.
authors.forename: Pascal
authors.initials: P
authors.lastname: Demoly
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D003888:Desensitization, Immunologic; D006297:Health Services Accessibility; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000276:immunology / Q000628:therapy*; D017063:Outcome Assessment, Health Care; D012107:Research Design; D016896:Treatment Outcome
keywords: Allergen immunotherapy (AIT); Allergic rhinitis; Clinical outcomes; Primary end point; Unmet needs