title: Adipsin Is Associated with Multiple Sclerosis: A Follow-Up Study of Adipokines.
abstract: Background and Objective. The role of adipokines in regulation of immune responses has been recognized, but very little is known about their impact on multiple sclerosis (MS). In this study, we analysed whether the major adipokines are differentially expressed in plasma of patients with different MS subtypes and clinically isolated syndrome (CIS) and explored their association with major disease characteristics. Methods. The levels of adiponectin, adipsin, leptin, and resistin in the plasma of 80 patients with different subtypes of MS and CIS were followed up annually over the two years. The data obtained were correlated with disease activity, EDSS and volumes of T1-weighted lesions (T1-LV), and fluid attenuation inversion recovery lesions (FLAIR-LV) on MRI. Results. In MS group, a correlation was found between the level of adipsin and EDSS score at baseline (r = 0.506, p < 0.001). In RRMS, the levels of adipsin correlated with EDSS scores (r = 0.542, p = 0.002), T1-LV (r = 0.410, p = 0.034), and FLAIR-LV (r = 0.601, p = 0.0001) at baseline and an increase in the T1-LV over the follow-up (r = 0.582, p = 0.003). Associations with other adipokines were not detected. Conclusion. Our exploratory study provides novel insights on the impact of adipokines in MS and suggests that adipsin exerts predictive potential as a biomarker of neurodegeneration.
authors.affiliation: Neuroimmunology Unit, Medical School, University of Tampere, Tampere University Hospital, Biokatu 10, 33520 Tampere, Finland.
authors.forename: Renuka
authors.initials: R
authors.lastname: Natarajan
authors.affiliation: Neuroimmunology Unit, Medical School, University of Tampere, Tampere University Hospital, Biokatu 10, 33520 Tampere, Finland.
authors.forename: Sanna
authors.initials: S
authors.lastname: Hagman
authors.affiliation: The Immunopharmacology Research Group, University of Tampere, School of Medicine and Tampere University Hospital, Medisiinarinkatu 3, 33520 Tampere, Finland.
authors.forename: Mari
authors.initials: M
authors.lastname: Hämälainen
authors.affiliation: The Immunopharmacology Research Group, University of Tampere, School of Medicine and Tampere University Hospital, Medisiinarinkatu 3, 33520 Tampere, Finland.
authors.forename: Tiina
authors.initials: T
authors.lastname: Leppänen
authors.affiliation: Department of Radiology, Medical Imaging Centre, Tampere University Hospital, Teiskontie 35, 33520 Tampere, Finland.
authors.forename: Prasun
authors.initials: P
authors.lastname: Dastidar
authors.affiliation: The Immunopharmacology Research Group, University of Tampere, School of Medicine and Tampere University Hospital, Medisiinarinkatu 3, 33520 Tampere, Finland.
authors.forename: Eeva
authors.initials: E
authors.lastname: Moilanen
authors.affiliation: Neuroimmunology Unit, Medical School, University of Tampere, Tampere University Hospital, Biokatu 10, 33520 Tampere, Finland ; Department of Neurology, Tampere University Hospital, Teiskontie 35, 33520 Tampere, Finland.
authors.forename: Irina
authors.initials: I
authors.lastname: Elovaara