title: MMP-2 serum concentrations predict mortality in hemodialysis patients: a 5-year cohort study.
abstract: BACKGROUND
  We evaluated the ability of matrix metalloproteinase (MMP)-2, MMP-9, myeloperoxidase, osteopontin and stromal cell-derived factor 1 to predict mortality in hemodialysis (HD) patients.
  
  
  METHODS
  One hundred forty HD patients were enrolled and followed from December 2007 until December 2012. At the end of this 5-year period, data were compared between the patients who were alive and those who had died.
  
  
  RESULTS
  The patients who alive were younger (56 vs. 63y), with lower frequency of diabetes mellitus (34.34% vs. 58.53%), higher concentrations of albumin (4.13 vs. 3.91mg/dl) and lower concentrations of MMP-2 (430.76 vs. 521.59ng/ml). Multivariate analysis showed that age (HR=1.03, p=0.02), diabetes mellitus (HR=2.395, p=0.012), albumin (HR=0.475, p=0.047) and MMP-2 (HR=1.003, p=0.005) were independent factors predicting mortality in HD patients. Receiver operating characteristic curve analysis showed that albumin (AUC=0.628, p=0.027) and MMP-2 (AUC=0.643, p=0.004) had a similar ability (p=0.76) to predict survival of HD patients.
  
  
  CONCLUSIONS
  Compared with albumin, serum MMP-2 is a non-inferior prognostic marker for predicting the survival of HD patients.
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Division of Nephrology, Department of Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan.
authors.forename: Kuang-Chih
authors.initials: KC
authors.lastname: Hsiao
authors.affiliation: Department of Nephrology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan.
authors.forename: Jen-Pi
authors.initials: JP
authors.lastname: Tsai
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Shun-Fa
authors.initials: SF
authors.lastname: Yang
authors.affiliation: Division of Nephrology, Department of Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan.
authors.forename: Wen-Chin
authors.initials: WC
authors.lastname: Lee
authors.affiliation: Division of Nephrology, Department of Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan.
authors.forename: Jong-Yu
authors.initials: JY
authors.lastname: Huang
authors.affiliation: Division of Nephrology, Department of Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan.
authors.forename: Shun-Chi
authors.initials: SC
authors.lastname: Chang
authors.affiliation: Division of Nephrology, Department of Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan.
authors.forename: Chun-Shuo
authors.initials: CS
authors.lastname: Hso
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Division of Nephrology, Department of Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan. Electronic address: chrcsmu@gmail.com.
authors.forename: Horng-Rong
authors.initials: HR
authors.lastname: Chang
mesh_terms: D000418:Albumins / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D012372:ROC Curve; D006435:Renal Dialysis / Q000401:mortality*; D012984:Software
chemical_list: D000418:Albumins; D015415:Biomarkers; D020778:Matrix Metalloproteinase 2
keywords: Albumin; Hemodialysis; Matrix metalloproteinase; Survival