title: Association between the V Leiden G1691A mutation and sudden sensorineural hearing loss in Italian population: a meta-analysis.
abstract: Epidemiological studies have reported inconsistent findings on the association between the V Leiden G1691A mutation and sudden sensorineural hearing loss (SSNHL) in Italian population. The aim of this meta-analysis was to clarify this association. PubMed, Embase, and the China National Knowledge Infrastructure (CNKI) were searched up to April 1, 2015. We used STATA12.0 to calculate summary odds ratios (ORs) with 95 % confidence intervals (CIs). Four studies including 958 patients were identified. Pooled data showed no significant association between V Leiden G1691A mutation and risk of SSNHL in Italian population: A vs. G (OR = 1.660, 95 % CI 0.428-6.446, P OR = 0.464) and AG vs. GG (OR = 1.680, 95 % CI 0.422-6.688, P OR = 0.462). The present meta-analysis suggests that V Leiden G1691A mutation is not significantly associated with increased risk of SSNHL disease in Italian population. Further large and well-designed studies are needed to confirm this association.
authors.affiliation: Department of Otolaryngology Head and Neck Tumor of Guangxi Zhuang Autonomous Region People's Hospital, Nanning, 530021, China. jingchengshu@126.com.
authors.forename: Jingcheng
authors.initials: J
authors.lastname: Shu
authors.affiliation: Department of Otolaryngology Head and Neck Tumor of Guangxi Zhuang Autonomous Region People's Hospital, Nanning, 530021, China.
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Si
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Shihua
authors.initials: S
authors.lastname: Yin
authors.affiliation: Department of Obstetrics and Gynecology of the Second People's Hospital, Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Meirong
authors.initials: M
authors.lastname: He
mesh_terms: D005165:Factor V / Q000235:genetics*; D006319:Hearing Loss, Sensorineural / Q000235:genetics*; D003639:Hearing Loss, Sudden / Q000235:genetics*; D006801:Humans; D007558:Italy; D009154:Mutation; D012306:Risk
chemical_list: C095381:factor V Leiden; D005165:Factor V
keywords: Meta-analysis; Mutation; Sudden sensorineural hearing loss; V Leiden