title: Late malignant transformation of vestibular schwannoma in the absence of irradiation: case report.
abstract: Late malignant transformation of vestibular schwannoma (VS) following irradiation has previously been reported 29 times in the literature. Here, the authors report the first late malignant transformation of VS unrelated to neurofibromatosis or radiation exposure. After undergoing a near-total excision of a histologically benign VS, the patient developed malignant regrowth of the tumor remnant 42 months after the primary excision. This case challenges the dogmatic belief of absolute causality between radiation exposure and late malignant transformation of VS, and has important implications regarding future counseling and consent for the treatment of patients with VS.
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Asma
authors.initials: A
authors.lastname: Bashir
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Lars
authors.initials: L
authors.lastname: Poulsgaard
authors.affiliation: Pathology, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
authors.forename: Helle
authors.initials: H
authors.lastname: Broholm
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Kåre
authors.initials: K
authors.lastname: Fugleholm
mesh_terms: D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000473:pathology*
keywords: MIB-1 index; MPNST = malignant peripheral nerve sheath tumor; NF2 = neurofibromatosis Type 2; SRS = stereotactic radiosurgery; SRT = stereotactic radiotherapy; VS = vestibular schwannoma; malignant peripheral nerve sheath tumor; malignant transformation; oncology; tumor recurrence; vestibular schwannoma