title: An unusual case of enoxaparin induced thrombocytopenia in intensive care unit.
abstract: OBJECTIVE
  To present a case of heparin induced thrombocytopenia in a patient treated with enoxaparin.
  
  
  METHODS
  A case of heparin-induced thrombocytopenia was examinated with a detailed platelet count analysis over the time and with detection of platelets antibodies.
  
  
  RESULTS
  The detection of platelet antobodies and the recovery of platelet count after cessation of enoxaparin strongly support the diagnosis of heparin-induced thrombocytopenia (HIT).
  
  
  CONCLUSIONS
  HIT is a severe side effects of heparin administration. It is more frequent in patients treated with unfractionated heparin however can also be induced by low molecular weight heparin. Guideline suggests the cessation of heparin administration and the treatment of patients with fondaparinux.
  
  
  BACKGROUND
  Enoxaparin, Heparin induced thrombocytopenia, Thrombocytopenia.
authors.forename: Enrico
authors.initials: E
authors.lastname: Giuliani
authors.forename: Gabriele
authors.initials: G
authors.lastname: Melegari
authors.forename: Alberto
authors.initials: A
authors.lastname: Farinetti
authors.forename: Alberto
authors.initials: A
authors.lastname: Barbieri
authors.forename: Anna Vittoria
authors.initials: AV
authors.lastname: Mattioli
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D057915:Drug Substitution; D004379:Duodenal Neoplasms / Q000601:surgery; D017984:Enoxaparin / Q000009:adverse effects*; D005260:Female; D000077425:Fondaparinux; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007362:Intensive Care Units; D008875:Middle Aged; D010195:Pancreatitis / Q000209:etiology / Q000628:therapy; D011134:Polysaccharides / Q000627:therapeutic use; D011183:Postoperative Complications / Q000139:chemically induced* / Q000209:etiology / Q000276:immunology / Q000628:therapy; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology
chemical_list: D000925:Anticoagulants; D001323:Autoantibodies; D017984:Enoxaparin; D007074:Immunoglobulin G; D011134:Polysaccharides; D000077425:Fondaparinux