title: [PATIENTS WITH HAVE A LEVEL OF ENDOTHELIN-1 AN ANTIFOSFOLIPID SYNDROME: CONNECTION IS WITH MOTION OF DISEASE, DISFUNCTION OF ENDOTHELIA AND ATHEROSCLEROSIS].
abstract: In the article the concentration of endothelin-1 in patients with different variants of APS was analyzed and its relationship with disease course, dyslipidemia, levels of antiphospholipid antibodies and ath rosclerotic vascular lesions was assessed. It was established that high levels of endothelin-1 is a circulating marker of early atherosclerosis, since !it was closely associated'with subclinical manifestations of atherosclerotic vascular lesions, lipid profile. The concentration of endothelin-1 significantly increased with active inflammation and with high levels of antiphospholipid antibodies and does not depend on age, sex, smoking, obesity and physical inactivity.
authors.forename: I
authors.initials: I
authors.lastname: Kuvikova
authors.forename: S
authors.initials: S
authors.lastname: Shevchuk
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D050197:Atherosclerosis / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D018450:Disease Progression; D050171:Dyslipidemias / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D042241:Early Diagnosis; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D019332:Endothelin-1 / Q000097:blood*; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000503:physiopathology; D012907:Smoking / Q000503:physiopathology
chemical_list: D017152:Antibodies, Antiphospholipid; D015415:Biomarkers; D019332:Endothelin-1