title: Effects on lipid profile of supplementation with vitamin D in type 2 diabetic patients with vitamin D deficiency.
abstract: BACKGROUND
  Epidemiological studies suggest that vitamin D status may have an influence on lipid profile.
  
  
  METHODS
  We studied consecutive type 2 diabetic patients with vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D) lower than 20 ng/ml). They were treated with 16,000 IU of calcifediol orally once a week for a minimum of 8 weeks.
  
  
  RESULTS
  A total of 28 patients were treated for a mean time of 84.1 days (range 56-120 days). All patients achieved serum levels of 25(OH)D higher than 20 ng/ml. There was significant reduction in total cholesterol (172.1 ± 32.4 versus 164.4 ± 27.3 mg/dl, p = 0.04). There were nonsignificant reductions in low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (non-HDL) cholesterol and triglycerides. There was no change in HDL cholesterol.
  
  
  CONCLUSIONS
  Correction of vitamin D deficiency in type 2 diabetic patients decreases total cholesterol. Our results do not rule out reductions in LDL cholesterol, non-HDL cholesterol and triglycerides.
authors.affiliation: Internal Medicine Service, Hospital Ciudad de Coria, Coria (Cáceres), Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Ramiro-Lozano
authors.affiliation: Internal Medicine Service, Hospital Ciudad de Coria, C/ Cervantes 75, 10800 Coria (Cáceres), Spain.
authors.forename: José María
authors.initials: JM
authors.lastname: Calvo-Romero
keywords: cholesterol; lipids; triglycerides; type 2 diabetes mellitus; vitamin D