title: Adiponectin gene polymorphisms are associated with increased susceptibility to diabetic peripheral neuropathy.
abstract: BACKGROUND
  Adiponectin (ADP) polymorphisms associated with diabetes mellitus in several populations. However, no previous studies have investigated its association with diabetic peripheral neuropathy (DPN). Our study examined the association between ADP-linked SNPs and DPN susceptibility.
  
  
  METHODS
  We randomly recruited 160 diabetes mellitus (DM) patients and 80 healthy individuals.
  
  
  RESULTS
  The C allele of rs3821799 increased DPN susceptibility. In normal individuals, GG of rs3774261 carriers had 7.1 times higher DPN susceptibility than AA carriers. The haplotype analyzes indicated CGG might increase DPN susceptibility.
  
  
  CONCLUSIONS
  Our study demonstrated that ADP gene polymorphisms are associated with the susceptibility to DPN.
authors.affiliation: a Department of Endocrinology , Fujian Medical University Union Hospital, Endocrinology Institute of Fujian , Fuzhou , P.R. China .
authors.forename: Yao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: a Department of Endocrinology , Fujian Medical University Union Hospital, Endocrinology Institute of Fujian , Fuzhou , P.R. China .
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: a Department of Endocrinology , Fujian Medical University Union Hospital, Endocrinology Institute of Fujian , Fuzhou , P.R. China .
authors.forename: Lijing
authors.initials: L
authors.lastname: Wang
authors.affiliation: a Department of Endocrinology , Fujian Medical University Union Hospital, Endocrinology Institute of Fujian , Fuzhou , P.R. China .
authors.forename: Peiji
authors.initials: P
authors.lastname: Huang
authors.affiliation: b Department of Intervention , Handan Central Hospital , Handan , P.R. China , and.
authors.forename: Zeng-Xian
authors.initials: ZX
authors.lastname: Tan
authors.affiliation: c Department of Medical Imaging , The Second Hospital of Hebei Medical University , Shijiazhuang , P.R. China.
authors.forename: Huai-Jun
authors.initials: HJ
authors.lastname: Liu
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000483:Alleles; D001483:Base Sequence; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003929:Diabetic Neuropathies / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006442:Glycated Hemoglobin / Q000378:metabolism; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA / Q000379:methods; D013954:Thyroglobulin / Q000097:blood
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D002784:Cholesterol; D006442:Glycated Hemoglobin; D008077:Lipoproteins, LDL; D013954:Thyroglobulin; C499918:ADIPOQ protein, human
keywords: Adiponectin; diabetic peripheral neuropathy; haplotype analysis; single nucleotide polymorphisms; susceptibility