title: The role of immune mechanisms in alcoholic and nonalcoholic steatohepatitis: a 2015 update.
abstract: So far, innate immune mechanisms have been recognized as the main responsible for the evolution of both alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH). However, increasing evidence points toward the possible role of adaptive immune responses, as an additional factor in promoting hepatic inflammation in steatohepatitis. In this article, we discuss recent data involving circulating antibodies and lymphocyte-mediated responses in sustaining the progression of ASH and NASH to fibrosis, as well as the possible mechanisms implicated in favoring the onset of adaptive immunity in the setting of steatohepatitis.
authors.affiliation: a Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune Diseases , University "Amedeo Avogadro" of East Piedmont , Novara , Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Sutti
authors.affiliation: a Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune Diseases , University "Amedeo Avogadro" of East Piedmont , Novara , Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Bruzzì
authors.affiliation: a Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune Diseases , University "Amedeo Avogadro" of East Piedmont , Novara , Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Albano
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000906:Antibodies / Q000097:blood / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007167:Immunotherapy / Q000379:methods; D018836:Inflammation Mediators / Q000097:blood / Q000276:immunology; D008099:Liver / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D008214:Lymphocytes / Q000276:immunology; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D018384:Oxidative Stress
chemical_list: D000906:Antibodies; D018836:Inflammation Mediators
keywords: Alcoholic liver disease (ALD); T-lymphocytes; lipid peroxidation; liver fibrosis; natural killer T cells; nonalcoholic fatty liver diseases (NAFLD); oxidative stress