title: Gene Therapy-Based Modeling of Neurodegenerative Disorders: Huntington's Disease.
abstract: Huntington's disease is a fatal neurodegenerative disease characterized by impairments in motor control, and cognitive and psychiatric disturbances. In this chapter, viral vector-mediated approaches used in modeling the key neuropathological features of the disease including the production of abnormal intracellular protein aggregates, neuronal dysfunction and degeneration and motor impairments in rodents are described.
authors.affiliation: Department of Pharmacology & Clinical Pharmacology & Centre for Brain Research, School of Medical Sciences, University of Auckland, Auckland, New Zealand. ds.young@auckland.ac.nz.
authors.forename: Deborah
authors.initials: D
authors.lastname: Young
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009474:Neurons
chemical_list: C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins
keywords: Genetic; Huntingtin; Neurodegenerative disease; Neurons; Transgenic; Viral vector