title: Treatment of neonates with meconium aspiration syndrome by proportional assist ventilation and synchronized intermittent mandatory ventilation: a comparison study.
abstract: BACKGROUND
  This study aimed to compare the relevant clinical parameters of neonates with MAS who are supported by proportion assisted ventilation (PAV) and synchronized intermittent mandatory ventilation (SIMV).
  
  
  METHODS
  Forty neonates diagnosed as MAS who required mechanical ventilation were divided randomly into PAV group and SIMV group (N.=20). The respiratory rate (RR), heart rate (HR), peak inspiratory pressure (PIP), mean arterial blood pressure (MABP), arterial-to-alveolar oxygen tension ratio (a/APO2), fraction of inspiration oxygen (FiO2), mean airway pressure (MAP) and tidal volume (VT) were measured before the ventilation, 1,12, 24, 48 hours after the ventilation and before weaning.
  
  
  RESULTS
  We observed no significant differences in the mechanical ventilation time, oxygen supply time, hospital stay between PAV and SIMV groups. In addition, we found no significant differences in HR, MABP, a/APO2 and FiO2 at every time point between two groups (P>0.05). However, we observed significant differences in RR, MAP, PIP and VT at every time point between two groups (P<0.05).
  
  
  CONCLUSIONS
  PAV and SIMV might be a useful ventilator mode to support the neonates with MAS who require ventilation. To achieve the same effect, PAV adopts rapid shallow breathing pattern, with smaller tidal volume and lower MAP and PIP.
authors.affiliation: Neonatal Medical Center, Huaian Maternity and Child Healthcare Hospital, Yangzhou University Medical School, Huaian, China - wr618@126.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Wu
authors.forename: Zhao-Fang
authors.initials: ZF
authors.lastname: Tian
authors.forename: Guo-Fang
authors.initials: GF
authors.lastname: Zheng
authors.forename: Su-Fang
authors.initials: SF
authors.lastname: Din
authors.forename: Zi-Bo
authors.initials: ZB
authors.lastname: Gao
authors.forename: Zhi-Chun
authors.initials: ZC
authors.lastname: Feng
mesh_terms: D062186:Arterial Pressure / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D059725:Interactive Ventilatory Support / Q000379:methods*; D007385:Intermittent Positive-Pressure Ventilation / Q000379:methods*; D008297:Male; D008471:Meconium Aspiration Syndrome / Q000628:therapy*; D010100:Oxygen / Q000378:metabolism; D012121:Respiration, Artificial / Q000379:methods*; D056152:Respiratory Rate / Q000502:physiology; D013990:Tidal Volume / Q000502:physiology; D013997:Time Factors
chemical_list: D010100:Oxygen