title: Etanercept treatment-related c-ANCA-associated large vessel vasculitis.
abstract: Anti-tumor necrosis factor (TNF) agents have become central players in the management of autoimmune and rheumatic disease. With the wide use of anti-TNF agents today, we have become aware of rare autoimmune complications as systemic lupus erythematosus and psoriasis, yet rarely has large vessels vasculitis been described. We herein describe a case of cytoplasmic anti-neutrophil cytoplasmic antibody (c-ANCA) (with myeloperoxidase (MPO) antibodies)-associated large vessel vasculitis (aortitis) that developed during anti-TNF treatment for ankylosing spondylitis. Awareness of this rare, but serious, adverse event of these commonly used agents in rheumatic diseases is of importance.
authors.affiliation: Department of Rheumatology, Bnai Zion Medical Center, Ruth and Bruce Rappaport Faculty of Medicine, Technion, 47 Golomb St., 31048, Haifa, Israel. shiragins@gmail.com.
authors.forename: Shira
authors.initials: S
authors.lastname: Ginsberg
authors.affiliation: Department of Rheumatology, Bnai Zion Medical Center, Ruth and Bruce Rappaport Faculty of Medicine, Technion, 47 Golomb St., 31048, Haifa, Israel.
authors.forename: Itzhak
authors.initials: I
authors.lastname: Rosner
authors.affiliation: Department of Rheumatology, Bnai Zion Medical Center, Ruth and Bruce Rappaport Faculty of Medicine, Technion, 47 Golomb St., 31048, Haifa, Israel.
authors.forename: Gleb
authors.initials: G
authors.lastname: Slobodin
authors.affiliation: Department of Rheumatology, Bnai Zion Medical Center, Ruth and Bruce Rappaport Faculty of Medicine, Technion, 47 Golomb St., 31048, Haifa, Israel.
authors.forename: Nina
authors.initials: N
authors.lastname: Boulman
authors.affiliation: Department of Rheumatology, Bnai Zion Medical Center, Ruth and Bruce Rappaport Faculty of Medicine, Technion, 47 Golomb St., 31048, Haifa, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Rozenbaum
authors.affiliation: Department of Rheumatology, Bnai Zion Medical Center, Ruth and Bruce Rappaport Faculty of Medicine, Technion, 47 Golomb St., 31048, Haifa, Israel.
authors.forename: Lisa
authors.initials: L
authors.lastname: Kaly
authors.affiliation: Department of Rheumatology, Bnai Zion Medical Center, Ruth and Bruce Rappaport Faculty of Medicine, Technion, 47 Golomb St., 31048, Haifa, Israel.
authors.forename: Ofrat Katz
authors.initials: OK
authors.lastname: Beyar
authors.affiliation: Department of Rheumatology, Bnai Zion Medical Center, Ruth and Bruce Rappaport Faculty of Medicine, Technion, 47 Golomb St., 31048, Haifa, Israel.
authors.forename: Doron
authors.initials: D
authors.lastname: Rimar
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D001025:Aortitis / Q000139:chemically induced* / Q000188:drug therapy; D000068800:Etanercept / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011241:Prednisone / Q000008:administration & dosage; D011860:Radiography, Abdominal; D012216:Rheumatic Diseases; D000069283:Rituximab / Q000008:administration & dosage; D013167:Spondylitis, Ankylosing / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed; D014409:Tumor Necrosis Factor-alpha / Q000009:adverse effects* / Q000037:antagonists & inhibitors
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D014409:Tumor Necrosis Factor-alpha; D000069283:Rituximab; D000068800:Etanercept; D011241:Prednisone
keywords: ANCA; Ankylosing spondylitis; Anti-TNF treatment; Associated vasculitis; Rheumatic diseases