title: Reconstruction of Skull Base Defects.
abstract: "Endoscopic endonasal skull base surgery has dramatically changed and expanded over recent years due to significant advancements in instrumentation, techniques, and anatomic understanding. With these advances, the need for more robust skull base reconstructive techniques was vital. In this article, reconstructive options ranging from acellular grafts to vascular flaps are described, including the strengths, weaknesses, and common uses."
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, 170 Manning Drive, CB# 7070, Chapel Hill, NC 27599-7070, USA.
authors.forename: Cristine N
authors.initials: CN
authors.lastname: Klatt-Cromwell
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, 170 Manning Drive, CB# 7070, Chapel Hill, NC 27599-7070, USA. Electronic address: brian_thorp@med.unc.edu.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Thorp
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, 170 Manning Drive, CB# 7070, Chapel Hill, NC 27599-7070, USA.
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Del Signore
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, 170 Manning Drive, CB# 7070, Chapel Hill, NC 27599-7070, USA.
authors.forename: Charles S
authors.initials: CS
authors.lastname: Ebert
authors.affiliation: Department of Neurosurgery, University of North Carolina at Chapel Hill, 170 Manning Drive, CB# 7060, Chapel Hill, NC 27599, USA.
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Ewend
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, 170 Manning Drive, CB# 7070, Chapel Hill, NC 27599-7070, USA; Department of Neurosurgery, University of North Carolina at Chapel Hill, 170 Manning Drive, CB# 7060, Chapel Hill, NC 27599, USA. Electronic address: adam_zanation@med.unc.edu.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Zanation
mesh_terms: D019468:Disease Management; D004724:Endoscopy / Q000379:methods*; D006801:Humans; D009666:Nose / Q000601:surgery; D019651:Plastic Surgery Procedures / Q000379:methods*; D019291:Skull Base / Q000601:surgery*; D019292:Skull Base Neoplasms / Q000601:surgery*; D013524:Surgical Flaps / Q000098:blood supply*; D016896:Treatment Outcome
keywords: CSF leak; Endoscopic skull base surgery; Nasoseptal flap; Pericranial flap; Skull base reconstruction; Temporoparietal flap