title: Hipersensitivity Reactions to Corticosteroids.
abstract: Corticosteroids are widely used drugs in the clinical practice, especially by topic application in dermatology. These substances may act as allergens and produce immediate and delayed hypersensitivity reactions. Allergic contact dermatitis is the most frequent presentation of corticosteroid allergy and it should be studied by patch testing in specific units. The corticosteroids included in the Spanish standard battery are good markers but not ideal. Therefore, if those makers are positive, it is useful to apply a specific battery of corticosteroids and the drugs provided by patients. Immediate reactions are relatively rare but potentially severe, and it is important to confirm the sensitization profile and to guide the use of alternative corticosteroids, because they are often necessary in several diseases. In this article we review the main concepts regarding these two types of hypersensitivity reactions in corticosteroid allergy, as well as their approach in the clinical practice.
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, España. Electronic address: lauraberbegal@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Berbegal
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, España.
authors.forename: F J
authors.initials: FJ
authors.lastname: DeLeon
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, España.
authors.forename: J F
authors.initials: JF
authors.lastname: Silvestre
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000485:Allergens / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D010328:Patch Tests
chemical_list: D000305:Adrenal Cortex Hormones; D000485:Allergens
keywords: Allergic contact dermatitis; Batería estándar; Corticoides; Corticosteroids; Dermatitis de contacto alérgica; Hypersensitivity reactions; Patch test; Pruebas epicutáneas; Reacciones de hipersensibilidad; Standard battery