title: Neonatal Care and Management of Foals Derived by Somatic Cell Nuclear Transfer.
abstract: There are few reports on the birth of foals resulting from equine adult somatic cell nuclear transfer (NT). On evaluation of reports of 28 live-born adult somatic-cell NT (clone) foals, 3 died within 2 weeks of birth of complications. Approximately 50 % of all reported cloned foals had complications, some requiring aggressive supportive care. The most common abnormalities reported were neonatal maladjustment syndrome, enlarged umbilical remnant, and angular deformity of the forelimbs, similar to problems described in cloned cattle. In contrast, large offspring syndrome and gross abnormalities of the fetal membranes which are described in cloned cattle are not reported in cloned foals. Reports of the health of foals produced by nuclear transfer suggest that NT foals should be treated aggressively as at-risk foals until all parameters are normal.
authors.affiliation: JT Vaughn Large Animal Teaching Hospital, College of Veterinary Medicine, Auburn University, 1500 Wire Road, Auburn, AL, 36849, USA. akj0001@auburn.edu.
authors.forename: Aime K
authors.initials: AK
authors.lastname: Johnson
authors.affiliation: Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77843-4466, USA. khinrichs@cvm.tamu.edu.
authors.forename: Katrin
authors.initials: K
authors.lastname: Hinrichs
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D019976:Cloning, Organism; D019468:Disease Management; D006734:Horse Diseases; D006736:Horses; D053652:Nuclear Transfer Techniques; D011181:Postnatal Care
keywords: Angular limb deformity; Clone; Equine; Foal; Neonatal maladjustment syndrome; Nuclear transfer; Umbilical enlargement