title: The role of microRNAs in the development and progression of chemical-associated cancers.
abstract: Human exposure to certain natural and man-made chemical carcinogens is one of the major risk factors for cancer development. The effect of chemical carcinogens on genetic and epigenetic alterations and their significance in the development of cancer has been well-established. In contrast, the role of microRNAs (miRNAs) in the etiology of chemical-associated cancers remains relatively unexplored despite extensive reports on changes in miRNA expression upon carcinogen exposure. This review summarizes the current knowledge for the role of miRNAs as drivers of chemical-induced carcinogenesis by bridging the gap between carcinogen exposure and cancer development through functional studies. It also emphasizes the potential for miRNA changes as early indicators of the carcinogenic process, markers for carcinogen exposure, and identification of chemical carcinogenic hazards.
authors.affiliation: Division of Biochemical Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: igor.pogribny@fda.hhs.gov.
authors.forename: Igor P
authors.initials: IP
authors.lastname: Pogribny
authors.affiliation: Division of Biochemical Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA.
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Beland
authors.affiliation: Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA.
authors.forename: Ivan
authors.initials: I
authors.lastname: Rusyn
mesh_terms: D002273:Carcinogens / Q000633:toxicity*; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D009369:Neoplasms / Q000139:chemically induced* / Q000235:genetics / Q000473:pathology*
chemical_list: D002273:Carcinogens; D035683:MicroRNAs
keywords: Cancer; Chemical carcinogens; Exposure; microRNAs