title: High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides.
abstract: We demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding affinity, sequence selectivity, and high cytotoxicity towards a set of cancer cell lines.
authors.affiliation: Departamento de Química Inorgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. miguel.vazquez.lopez@usc.es.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Gamba
authors.affiliation: Departamento de Química Inorgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. miguel.vazquez.lopez@usc.es.
authors.forename: Iria
authors.initials: I
authors.lastname: Salvadó
authors.affiliation: Departament de Química Inorgánica, QBI, Universitat de Barcelona, 08028 Barcelona, Spain.
authors.forename: Rosa F
authors.initials: RF
authors.lastname: Brissos
authors.affiliation: Departament de Química Inorgánica, QBI, Universitat de Barcelona, 08028 Barcelona, Spain and Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Spain.
authors.forename: Patrick
authors.initials: P
authors.lastname: Gamez
authors.affiliation: Grupo de Investigación BioFarma/Plataforma de Screening USEF, Centro de Investigación CIMUS, Universidade de Santiago de Compostela, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Brea
authors.affiliation: Grupo de Investigación BioFarma/Plataforma de Screening USEF, Centro de Investigación CIMUS, Universidade de Santiago de Compostela, Spain.
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Loza
authors.affiliation: Departamento de Química Orgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. eugenio.vazquez@usc.es.
authors.forename: M Eugenio
authors.initials: ME
authors.lastname: Vázquez
authors.affiliation: Departamento de Química Inorgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. miguel.vazquez.lopez@usc.es.
authors.forename: Miguel
authors.initials: M
authors.lastname: Vázquez López
mesh_terms: D004247:DNA / Q000378:metabolism*; D007495:Iridium / Q000378:metabolism*; D008667:Metalloproteins / Q000378:metabolism*; D018625:Microscopy, Atomic Force; D009942:Organometallic Compounds / Q000378:metabolism*
chemical_list: D008667:Metalloproteins; D009942:Organometallic Compounds; D007495:Iridium; D004247:DNA