title: Cell Receptor-Basement Membrane Interactions in Health and Disease: A Kidney-Centric View.
abstract: Cell-extracellular matrix (ECM) interactions are essential for tissue development, homeostasis, and response to injury. Basement membranes (BMs) are specialized ECMs that separate epithelial or endothelial cells from stromal components and interact with cells via cellular receptors, including integrins and discoidin domain receptors. Disruption of cell-BM interactions due to either injury or genetic defects in either the ECM components or cellular receptors often lead to irreversible tissue injury and loss of organ function. Animal models that lack specific BM components or receptors either globally or in selective tissues have been used to help with our understanding of the molecular mechanisms whereby cell-BM interactions regulate organ function in physiological and pathological conditions. We review recently published works on animal models that explore how cell-BM interactions regulate kidney homeostasis in both health and disease.
authors.affiliation: Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Corina M
authors.initials: CM
authors.lastname: Borza
authors.affiliation: Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Xiwu
authors.initials: X
authors.lastname: Chen
authors.affiliation: Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Medicine, Veterans Administration Hospital, Nashville, TN, USA.
authors.forename: Roy
authors.initials: R
authors.lastname: Zent
authors.affiliation: Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Medicine, Veterans Administration Hospital, Nashville, TN, USA.
authors.forename: Ambra
authors.initials: A
authors.lastname: Pozzi
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000166:cytology* / Q000378:metabolism / Q000473:pathology*; D007674:Kidney Diseases / Q000378:metabolism* / Q000473:pathology*; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface
keywords: Alport syndrome; Basement membrane; Discoidin domain receptors; Extracellular matrix; Integrins; Kidney; Mouse models; Peroxidasin; Pierson syndrome; Tubular cells