title: Primary phospholipase C and brain disorders.
abstract: In the brain, the primary phospholipase C (PLC) proteins, PLCβ, and PLCγ, are activated primarily by neurotransmitters, neurotrophic factors, and hormones through G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). Among the primary PLC isozymes, PLCβ1, PLCβ4, and PLCγ1 are highly expressed and differentially distributed, suggesting a specific role for each PLC subtype in different regions of the brain. Primary PLCs control neuronal activity, which is important for synapse function and development. In addition, dysregulation of primary PLC signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. In this review, we included current knowledge regarding the roles of primary PLC isozymes in brain disorders.
authors.affiliation: Center for Cell to Cell Communication in Cancers (C5), School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, 689-798, Republic of Korea.
authors.forename: Yong Ryoul
authors.initials: YR
authors.lastname: Yang
authors.affiliation: Center for Cell to Cell Communication in Cancers (C5), School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, 689-798, Republic of Korea.
authors.forename: Du-Seock
authors.initials: DS
authors.lastname: Kang
authors.affiliation: Center for Cell to Cell Communication in Cancers (C5), School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, 689-798, Republic of Korea.
authors.forename: Cheol
authors.initials: C
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, Jungwon University, Goesan, Chungcheongbukdo, Republic of Korea.
authors.forename: Heon
authors.initials: H
authors.lastname: Seok
authors.affiliation: Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
authors.forename: Matilde Y
authors.initials: MY
authors.lastname: Follo
authors.affiliation: Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
authors.forename: Lucio
authors.initials: L
authors.lastname: Cocco
authors.affiliation: Center for Cell to Cell Communication in Cancers (C5), School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, 689-798, Republic of Korea. Electronic address: pgsuh@unist.ac.kr.
authors.forename: Pann-Ghill
authors.initials: PG
authors.lastname: Suh
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D001714:Bipolar Disorder / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D001921:Brain / Q000201:enzymology* / Q000473:pathology; D003863:Depression / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D004827:Epilepsy / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D006816:Huntington Disease / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D009414:Nerve Growth Factors / Q000235:genetics / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D054799:Phospholipase C beta / Q000235:genetics* / Q000378:metabolism; D051966:Phospholipase C gamma / Q000235:genetics* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D015398:Signal Transduction
chemical_list: D009414:Nerve Growth Factors; D018377:Neurotransmitter Agents; D043562:Receptors, G-Protein-Coupled; C518033:PLCB1 protein, human; C518042:PLCB4 protein, human; C522157:PLCG1 protein, human; D054799:Phospholipase C beta; D051966:Phospholipase C gamma
keywords: Brain disorder; PLCβ1; PLCβ4; PLCγ1; Phospholipase C