title: Thymus catharinae Camarda essential oil: β-cyclodextrin inclusion complexes, evaluation of antimicrobial activity.
abstract: An efficient antimicrobial activity was evidenced in a complex β-cyclodextrin-essential oil of Thymus catharinae Camarda (carvacrol chemotype). The release of carvacrol with respect to the antimicrobial activity was calculated as function of time. The βCD-complex of the bioactive agent was obtained by a simple, efficient and non-expensive method without purification of the carvacrol chemotype essential oil. According to the starting stoichiometry of β-cyclodextrin with respect to carvacrol, two inclusion complexes were produced, 1:1 and 2:1, respectively. The results demonstrate that, although the antimicrobial activity of the essential oil of T. catharinae Camarda is remarkable but acts too quickly in some types of application, its inclusion in a bio-matrix allows a slower release and improves its effectiveness.
authors.affiliation: a Consiglio Nazionale delle Ricerche (C.N.R.) Istituto di Chimica Biomolecolare, Traversa la Crucca , Li Punti- Sassari , Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Delogu
authors.affiliation: b Dipartimento di Chimica e Farmacia , Università degli Studi di Sassari , Sassari , Italy.
authors.forename: Claudia Clelia Assunta
authors.initials: CC
authors.lastname: Juliano
authors.affiliation: c Dipartimento di Scienze della Natura e del Territorio , Università degli Studi di Sassari , Sassari , Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Usai
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D000081007:Cymenes; D004926:Escherichia coli / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D046930:Thymus Plant / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000081007:Cymenes; D039821:Monoterpenes; D009822:Oils, Volatile; D047392:beta-Cyclodextrins; C073316:carvacrol
keywords: C. albicans; E. coli; Thymus catharinae Camarda; antimicrobial; carvacrol; cyclodextrin inclusion complex; essential oil