title: A 13-Year Retrospective Study of Basal Cell Carcinoma in a Canadian Dermatology Practice: A Comparison Between Anatomical Location and Histopathologic Subtypes.
abstract: BACKGROUND
  It is unknown whether the histologic subtypes of basal cell carcinoma (BCC) arise from a common progenitor cell or whether other factors play a role in their development.
  
  
  OBJECTIVE
  To investigate the relationship between the different BCC histopathologic subtypes and anatomical distribution of BCCs in a Canadian dermatology practice.
  
  
  METHODS
  The charts of all patients diagnosed with BCC between 1993 and 2005 from a single private dermatology practice in Vancouver, Canada, were reviewed. Descriptive data analysis was undertaken to look at the distribution of histologic subtypes based on age, gender, and anatomical location.
  
  
  RESULTS
  Nodular BCCs accounted for 58% of all tumors. Sixty-six percent of these were situated on the head/neck (odds ratio [OR] = 3.0, 95% confidence interval [CI] = 2.1-4.3, P < .0001). Infiltrative (OR = 2.4, 95% CI = 1.5-4.1, P = .0003) and superficial BCCs were more common in women (OR = 3.7, 95% CI = 2.5-5.7, P < .0001), affected the trunk (OR = 3.2, 95% CI = 2.1-4.9, P < .0001), and appeared in younger individuals (OR = 1.8, 95% CI = 1.2-2.7, P = .004).
  
  
  CONCLUSIONS
  Our results show a preference of distinct BCC subtypes for certain anatomical locations.
authors.affiliation: Department of Dermatology and Skin Science, University of British Columbia and Pacific Dermaesthetics, Vancouver, BC, Canada jasonrivers@shaw.ca.
authors.forename: Jason K
authors.initials: JK
authors.lastname: Rivers
authors.affiliation: Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Bhavik D
authors.initials: BD
authors.lastname: Mistry
authors.affiliation: DynalifeDx, University of Alberta, Departments of Pathology and Dermatology, University of Alberta, Edmonton, AB, Canada.
authors.forename: Tawny
authors.initials: T
authors.lastname: Hung
authors.affiliation: Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Kateryna
authors.initials: K
authors.lastname: Vostretsova
authors.affiliation: Department of Medicine (Dermatology), University of Toronto, Toronto, ON, Canada.
authors.forename: Nisha
authors.initials: N
authors.lastname: Mistry
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002170:Canada; D002280:Basal Cell Carcinoma / Q000473:pathology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D012737:Sex Factors; D012878:Skin Neoplasms / Q000473:pathology*; D060726:Torso; D055815:Young Adult
keywords: cancer; dermatology; pathology