title: Pretreatment serum xanthophyll concentrations as predictors of head and neck cancer recurrence and survival.
abstract: The purpose of this study was to examine associations of pretreatment serum carotenoids, tocopherols, and quercetin with prognosis in 154 patients newly diagnosed with head and neck cancer.
  
  
  
  Pretreatment blood and health surveys were collected. Serum micronutrients were measured by high performance liquid chromatography. Data on recurrence and death were collected annually. Cox proportional hazards models measured associations of serum nutrient concentrations with recurrence and overall survival.
  
  
  
  During a median follow-up time of 37 months, there were 32 recurrences and 27 deaths. After controlling for covariates, subjects with high versus low serum xanthophyll and total carotenoid concentrations had significantly longer recurrence-free time (p = .002 and p = .02, respectively). Overall survival time was significantly longer in patients with high versus low serum xanthophyll concentrations (p = .02).
  
  
  
  Future research should evaluate the possible benefits of interventions to increase intakes of rich food sources of xanthophylls in this patient population. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1591-E1597, 2016.
authors.affiliation: Department of Nutrition Sciences, University of Alabama-Birmingham, Birmingham, Alabama.|Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan.
authors.forename: Anna E
authors.initials: AE
authors.lastname: Arthur
authors.affiliation: Department of Biostatistics, University of Michigan, Ann Arbor, Michigan.|Center for Cancer Biostatistics, University of Michigan, Ann Arbor, Michigan.
authors.forename: Emily L
authors.initials: EL
authors.lastname: Bellile
authors.affiliation: Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan.|Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Laura S
authors.initials: LS
authors.lastname: Rozek
authors.affiliation: Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan.|Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts.
authors.forename: Karen E
authors.initials: KE
authors.lastname: Peterson
authors.affiliation: Department of Family Medicine, University of Michigan, Ann Arbor, Michigan.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Family Medicine, University of Michigan, Ann Arbor, Michigan.
authors.forename: Ethan
authors.initials: E
authors.lastname: Harris
authors.affiliation: Department of Family Medicine, University of Michigan, Ann Arbor, Michigan.
authors.forename: Christie
authors.initials: C
authors.lastname: Mueller
authors.affiliation: Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Shruti
authors.initials: S
authors.lastname: Jolly
authors.affiliation: Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Peterson
authors.affiliation: Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan.
authors.forename: Gregory T
authors.initials: GT
authors.lastname: Wolf
authors.affiliation: Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan.|Department of Family Medicine, University of Michigan, Ann Arbor, Michigan.
authors.forename: Zora
authors.initials: Z
authors.lastname: Djuric
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002338:Carotenoids / Q000097:blood; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood*; D011446:Prospective Studies; D011794:Quercetin / Q000097:blood; D015996:Survival Rate; D024505:Tocopherols / Q000097:blood; D024341:Xanthophylls / Q000097:blood*
chemical_list: D024341:Xanthophylls; D002338:Carotenoids; D011794:Quercetin; D024505:Tocopherols
keywords: head and neck cancer; quercetin; recurrence; serum micronutrients; survival; xanthophylls