title: Prospective cohort study to evaluate the efficacy of taxane plus platinum and CPT-11plus platinum regimes and to identify prognostic risk factors in cervical cancer patients.
abstract: OBJECTIVE
  This study was designed to evaluate the response, toxicity and survival of taxanes plus platinum (TP) and CPT-11plus platinum (CP) as neoadjuvant chemotherapies with previously untreated cervical cancer, and to identify prognostic risk factors in these patients.
  
  
  METHODS
  A cohort study was performed to evaluate the result of TP and CP regimes in the treatment of cervical cancer patients.
  
  
  RESULTS
  The study included 567 patients with locally advanced cervical cancer (LACC) staged as FIGO IB-IIB in our clinical departments. Clinical response was found in 76.1% and 78% of patients in the TP and CP arms, respectively, and no treatment-related deaths were reported. During the follow-up period, disease-free survival (DFS) and overall survival (OS) for the TP and CP arms were not different (P = 0.384 for DFS, P = 0.800 for OS). The CP regime showed higher survival rate for endophytic growth style (P = 0.013 for DFS, P = 0.027 for OS). The CP regime also showed higher DFS and OS for G2 tumor (P = 0.027 for DFS, P = 0.032 for OS). In multivariate cox's proportional hazards regression model, the average death rates were much greater in the non-responder group (HR, 2.68), in the older (> 44 years) group (HR, 2.51), and in the FIGO stage II b patients (HR, 2.84).
  
  
  CONCLUSIONS
  The CP regime showed higher survival rate for endophytic growth style or G2 tumor. Clinical response, age and FIGO stage were independent prognostic risk factors in this study for both DFS and OS.
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology PR China.
authors.forename: Kecheng
authors.initials: K
authors.lastname: Huang
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology PR China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Li
authors.affiliation: Henan Cancer Hospital PR China.
authors.forename: Ru
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynecology, Wuhan Central Hospital Wuhan, Hubei, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Obstetrics and Gynecology, Wuhan General Hospital of Guangzhou Military Command Wuhan, Hubei, PR China.
authors.forename: Zhilan
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Obstetrics and Gynecology, Xiangfan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology Xiangfan, Hubei, PR China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology PR China.
authors.forename: Shaoshuai
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology PR China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology PR China.
authors.forename: Fangxu
authors.initials: F
authors.lastname: Tang
authors.affiliation: Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing, Jiangsu, PR China.
authors.forename: Hang
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology PR China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology PR China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology PR China.
authors.forename: Lili
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology PR China.
authors.forename: Long
authors.initials: L
authors.lastname: Qiao
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology PR China.
authors.forename: Jiaqiang
authors.initials: J
authors.lastname: Xiong
authors.affiliation: The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, PR China.
authors.forename: Congyi
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology PR China.
authors.forename: Ding
authors.initials: D
authors.lastname: Ma
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology PR China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology PR China.
authors.forename: Ting
authors.initials: T
authors.lastname: Hu
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology PR China.
authors.forename: Shixuan
authors.initials: S
authors.lastname: Wang
keywords: Cervical cancer; irinotecan; neoadjuvant chemotherapy; platinum; taxane