title: Redox Modulations, Antioxidants, and Neuropsychiatric Disorders.
abstract: Although antioxidants, redox modulations, and neuropsychiatric disorders have been widely studied for many years, the field would benefit from an integrative and corroborative review. Our primary objective is to delineate the biological significance of compounds that modulate our redox status (i.e., reactive species and antioxidants) as well as outline their current role in brain health and the impact of redox modulations on the severity of illnesses. Therefore, this review will not enter into the debate regarding the perceived medical legitimacy of antioxidants but rather seek to clarify their abilities and limitations. With this in mind, antioxidants may be interpreted as natural products with significant pharmacological actions in the body. A renewed understanding of these often overlooked compounds will allow us to critically appraise the current literature and provide an informed, novel perspective on an important healthcare issue. In this review, we will introduce the complex topics of redox modulations and their role in the development of select neuropsychiatric disorders.
authors.affiliation: Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8 ; Department of Pharmacology, University of Toronto, Medical Science Building, 1 King's College Circle, Toronto, ON, Canada M5S 1A8.
authors.forename: Erik A
authors.initials: EA
authors.lastname: Fraunberger
authors.affiliation: Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8 ; Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON, Canada M5T 1R8.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Scola
authors.affiliation: Department of Pharmacology, University of Toronto, Medical Science Building, 1 King's College Circle, Toronto, ON, Canada M5S 1A8.
authors.forename: Victoria L M
authors.initials: VL
authors.lastname: Laliberté
authors.affiliation: Department of Pharmacology, University of Toronto, Medical Science Building, 1 King's College Circle, Toronto, ON, Canada M5S 1A8.
authors.forename: Angela
authors.initials: A
authors.lastname: Duong
authors.affiliation: Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8 ; Department of Pharmacology, University of Toronto, Medical Science Building, 1 King's College Circle, Toronto, ON, Canada M5S 1A8 ; Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON, Canada M5T 1R8.
authors.forename: Ana C
authors.initials: AC
authors.lastname: Andreazza
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism*; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000378:metabolism; D009422:Nervous System Diseases / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000975:Antioxidants