title: Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression.
abstract: OBJECTIVE
  Laser-assisted drug delivery is an emerging technology to achieve greater penetration by existing topical medications to reach desired targets in the tissue. The objective of this research was to study whether laser-assisted delivery of Vitamin C, E, and Ferulic immediately postoperatively of fractional ablative laser could improve wound healing. Secondary objectives were to evaluate the potential molecular markers involved in this wound-healing process.
  
  
  METHODS
  A double blinded, prospective, single center, randomized split face trial of Vitamin C, E, and Ferulic topical formula #740019 to decrease postoperative recovery time in fractional ablative laser resurfacing for photo damage. Fifteen healthy men and women of ages 30-55 years were treated with the Vitamin C, E, and Ferulic acid serum to one side of face and vehicle to the other side of face, within 2 minutes immediately after fractional ablative CO2 laser surgery and daily during the healing process. Patients were evaluated daily on days 1-7 using photographs, patient questionnaires, and molecular evaluation.
  
  
  RESULTS
  Clinically, postoperative Vitamin C, E, and Ferulic delivery resulted in decreased edema versus vehicle on postoperative day 7 and decreased erythema versus vehicle on postoperative days 3 and 5. Molecularly, the expression of basic fibroblast growth factor (bFGF) was significantly increased at day 5 on the lesion treated with Vitamin C, E, and Ferulic acid serum compared to vehicle control on the other side.
  
  
  CONCLUSIONS
  This is first study to show that Vitamin C, E, and Ferulic acid correlate with more rapid wound healing post-fractional ablative laser. Elevated bFGF could be involved in the Vitamin C, E, and Ferulic acid-induced rapid wound healing.
authors.affiliation: Miami Dermatology and Laser Institute, 7800 SW 87th Avenue, Suite B200, Miami, Florida, 33173.
authors.forename: Jill S
authors.initials: JS
authors.lastname: Waibel
authors.affiliation: Henry Ford Immunology Program, Departments of Dermatology and Internal Medicine, Henry Ford Hospital, 1 Ford Place, Detroit, Michigan, 48202.
authors.forename: Qing-Sheng
authors.initials: QS
authors.lastname: Mi
authors.affiliation: Henry Ford Immunology Program, Henry Ford Hospital, 3031 W Grand Blvd., Detroit, Michigan, 48202.
authors.forename: David
authors.initials: D
authors.lastname: Ozog
authors.affiliation: Henry Ford Immunology Program, Department of Dermatology, Henry Ford Hospital, 1 Ford Place, Detroit, Michigan, 48202.
authors.forename: Le
authors.initials: L
authors.lastname: Qu
authors.affiliation: Henry Ford Immunology Program, Departments of Dermatology and Internal Medicine, Henry Ford Hospital, 1 Ford Place, Detroit, Michigan, 48202.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Miami Dermatology and Laser Institute, 7800 SW 87th Avenue, Suite B200, Miami, Florida, 33173.
authors.forename: Ashley
authors.initials: A
authors.lastname: Rudnick
authors.affiliation: Sk:n Clinic, 144 Harley Street, London, UK.
authors.forename: Firas
authors.initials: F
authors.lastname: Al-Niaimi
authors.affiliation: Duke University, 2351 Erwin Rd., Suite 3802, Durham, North Carolina, 27705.
authors.forename: Julie
authors.initials: J
authors.lastname: Woodward
authors.affiliation: Clínica Valéria Campos, Jundiaí, São Paulo, Brazil.
authors.forename: Valerie
authors.initials: V
authors.lastname: Campos
authors.affiliation: INSERM U1189, INSERM, 1 Avenue Oscar Lambret, Lille, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Mordon
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000494:pharmacology; D015415:Biomarkers / Q000378:metabolism; D003357:Cosmetic Techniques; D003373:Coumaric Acids / Q000008:administration & dosage* / Q000494:pharmacology; D062109:Dermatologic Surgical Procedures; D004311:Double-Blind Method; D004338:Drug Combinations; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D005346:Fibroblast Growth Factors / Q000378:metabolism; D006801:Humans; D054020:Lasers, Gas / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D015595:Skin Aging; D016896:Treatment Outcome; D014810:Vitamin E / Q000008:administration & dosage* / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D003373:Coumaric Acids; D004338:Drug Combinations; D014810:Vitamin E; D005346:Fibroblast Growth Factors; C004999:ferulic acid; D001205:Ascorbic Acid
keywords: drug delivery systems; wound healing