title: Tumors of the Testis: Morphologic Features and Molecular Alterations.
abstract: This article reviews the most frequently encountered tumor of the testis; pure and mixed malignant testicular germ cell tumors (TGCT), with emphasis on adult (postpubertal) TGCTs and their differential diagnoses. We additionally review TGCT in the postchemotherapy setting, and findings to be integrated into the surgical pathology report, including staging of testicular tumors and other problematic issues. The clinical features, gross pathologic findings, key histologic features, common differential diagnoses, the use of immunohistochemistry, and molecular alterations in TGCTs are discussed.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Brooke E
authors.initials: BE
authors.lastname: Howitt
authors.affiliation: Orchid Tissue Laboratory, St. Bartholomew's Hospital, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1A 7BE, UK. Electronic address: D.Berney@bartsandthelondon.nhs.uk.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Berney
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D003937:Diagnosis, Differential; D006801:Humans; D059785:Karyotype; D008297:Male; D009154:Mutation; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000473:pathology; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D018239:Seminoma / Q000235:genetics / Q000473:pathology; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Embryonal; Germ cell tumor; Seminoma; Teratoma; Testis; Yolk-sac tumor; i12p