title: Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa &amp; Koki Ito.
abstract: A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides--adonioside A (1) and adonioside B (6)--as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3).
authors.affiliation: Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea. jaewoo4848@naver.com.
authors.forename: Jae-Woo
authors.initials: JW
authors.lastname: Jung
authors.affiliation: Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea. nibaek@khu.ac.kr.
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.affiliation: Graduate School of Biotechnology and Department of Genetic Engineering, Kyung Hee University, Yongin 446-701, Korea. hbj3286@khu.ac.kr.
authors.forename: Jeon
authors.initials: J
authors.lastname: Hwang-Bo
authors.affiliation: Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea. ldkhhghh@khu.ac.kr.
authors.forename: Seung-Su
authors.initials: SS
authors.lastname: Lee
authors.affiliation: Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea. wlgo3411@hanmail.net.
authors.forename: Ji-Hae
authors.initials: JH
authors.lastname: Park
authors.affiliation: Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea. kyeonghwaseo@khu.ac.kr.
authors.forename: Kyeong-Hwa
authors.initials: KH
authors.lastname: Seo
authors.affiliation: Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea. life-kjh@hanmail.net.
authors.forename: Jung-Hwa
authors.initials: JH
authors.lastname: Kwon
authors.affiliation: Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea. jk3172@nate.com.
authors.forename: Eun-Ji
authors.initials: EJ
authors.lastname: Oh
authors.affiliation: Department of Herbal Crop Research, National Institute of Horicultural and Herbal Science, RDA, Eumseong 369-873, Korea. dylee0809@korea.kr.
authors.forename: Dae-Young
authors.initials: DY
authors.lastname: Lee
authors.affiliation: Graduate School of Biotechnology and Department of Genetic Engineering, Kyung Hee University, Yongin 446-701, Korea. ischung@khu.ac.kr.
authors.forename: In-Sik
authors.initials: IS
authors.lastname: Chung
authors.affiliation: Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea. bangmh68@khu.ac.kr.
authors.forename: Myun-Ho
authors.initials: MH
authors.lastname: Bang
mesh_terms: D031843:Adonis / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D002298:Cardenolides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides; D010936:Plant Extracts
keywords: Adonis multiflora; adonioside A; adonioside B; cardenolide; cytotoxic activity