title: Significance of Fas and FasL protein expression in cardiac carcinoma and local lymph node tissues.
abstract: OBJECTIVE
  To investigate the relation of Fas and Fas ligand (FasL) protein expression with carcinogenesis and metastasis of cardiac carcinoma.
  
  
  METHODS
  Immunohistochemistry was used to detect Fas and FasL protein expression in 64 cardiac carcinoma tissue samples and 20 normal gastric tissue samples. Relation between FasL and Fas expression, age and gender of gastric cancer patients, and pathological subtype and lymph node metastasis of gastric cancer was analyzed.
  
  
  RESULTS
  The Fas expression level was significantly higher in normal gastric tissue samples than in cardiac carcinoma tissue samples (85.0% vs. 25.0%, P<0.001), while the FasL expression level was significantly lower in normal gastric tissue samples than in cardiac carcinoma tissue samples (30.0% vs. 81.3%, P<0.001). The Fas expression level was significantly higher in invasive lymph nodes than in non-invasive lymph nodes (82.9% vs. 56.5%, P<0.003) and in well-differentiated gastric carcinoma tissue samples than in poorly-differentiated cardiac carcinoma tissue samples (50.0% vs. 18.0%, P=0.015). The FasL expression level was significantly lower in well-differentiated cardiac carcinoma tissue samples than in poorly- differentiated cardiac carcinoma tissue samples (42.9% vs. 84.0%, P=0.021). The Fas and FasL expression levels (25.0% and 81.3%) were significantly different in cardiac carcinoma tissue samples (P<0.001), but had a non-linear correlation (P=0.575).
  
  
  CONCLUSIONS
  Abnormal Fas and FasL expressions in cardiac carcinoma and lymph node tissues are involved in carcinogenesis and metastasis of gastric cancer.
authors.affiliation: Department of Thoracic Surgery, The Tumor Hospital of Henan Zhengzhou 450008, Henan Province, P. R. China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu Province, China ; Huai'an First People's Hospital, Nanjing Madical University Huaian 223300, Jiangsu Province, China.
authors.forename: Da-Fu
authors.initials: DF
authors.lastname: Xu
authors.affiliation: Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu Province, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Jiang
authors.affiliation: Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu Province, China.
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Ge
authors.affiliation: Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu Province, China.
authors.forename: Shi-Ying
authors.initials: SY
authors.lastname: Zheng
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000556:secondary; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D002299:Cardia / Q000737:chemistry* / Q000473:pathology; D016022:Case-Control Studies; D002454:Cell Differentiation; D016009:Chi-Square Distribution; D053222:Fas Ligand Protein / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000737:chemistry* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000473:pathology; D055815:Young Adult; D019014:fas Receptor / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; C491901:FAS protein, human; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D019014:fas Receptor
keywords: Cardiac carcinoma; Fas; Fas ligand FasL; lymph nodes