title: Adverse health effects and histological changes in white sturgeon (Acipenser transmontanus) exposed to dietary selenomethionine.
abstract: It has been shown that selenium (Se) released to the aquatic environment can have devastating effects on local wildlife. White sturgeon (Acipenser transmontanus) have a life history particularly susceptible to contaminants, and their protection is of interest as they are culturally and economically important, and many populations are classified as endangered. During the present 72-d dietary study, multiple signs of decreased health and Se lethality were observed. Juvenile white sturgeon were given diets containing 1.4 μg, 5.6 μg, 22.4 μg, or 104.4 μg selenomethionine/g food (dry mass). Selenium accumulated in muscle and liver tissue in a dose-dependent manner. Edema causing exophthalmos developed within 15 d and 23 d, and lethal effects occurred in 54% and 22% of fish in the high- and medium-dose groups, respectively. Growth and hepatosomatic index were significantly lower in the high-dose group, which also had a high incidence of food avoidance. Histology of the liver revealed a dose-dependent increase in melanomacrophage aggregates and decrease of energy stores, which indicated toxicity. These results indicate that white sturgeon are susceptible to the effects of Se accumulation over relatively short time periods. This stresses the need for continued sturgeon research and studies looking into the environmental fate and regulation of released Se. Environ Toxicol Chem 2016;35:1741-1750. © 2015 SETAC.
authors.affiliation: School of Environment and Sustainability, University of Saskatchewan, Saskatchewan, Canada.
authors.forename: Jenna
authors.initials: J
authors.lastname: Zee
authors.affiliation: Toxicology Centre, University of Saskatchewan, Saskatchewan, Canada.
authors.forename: Sarah
authors.initials: S
authors.lastname: Patterson
authors.affiliation: Toxicology Program, University of Saskatchewan, Saskatchewan, Canada.
authors.forename: Danielle
authors.initials: D
authors.lastname: Gagnon
authors.affiliation: School of Environment and Sustainability, University of Saskatchewan, Saskatchewan, Canada.|Toxicology Centre, University of Saskatchewan, Saskatchewan, Canada.
authors.forename: Markus
authors.initials: M
authors.lastname: Hecker
mesh_terms: D000818:Animals; D004032:Diet; D004305:Dose-Response Relationship, Drug; D054750:Ecotoxicology / Q000379:methods*; D005094:Exophthalmos / Q000139:chemically induced; D005399:Fishes / Q000254:growth & development* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008962:Models, Theoretical; D009132:Muscles / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D012645:Selenomethionine / Q000378:metabolism / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical; D012645:Selenomethionine
keywords: Aquatic toxicology; Histology; Histopathology; Metal accumulation; Selenium