title: A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies.
abstract: Previous studies have shown that sera from HIV-1-infected individuals contain antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC). These antibodies preferentially recognize envelope glycoprotein (Env) epitopes induced upon CD4 binding. Here, we show that a highly conserved tryptophan at position 69 of the gp120 inner domain is important for ADCC mediated by anti-cluster A antibodies and sera from HIV-1-infected individuals.
authors.affiliation: Centre de Recherche du CHUM, Montreal, QC, Canada Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada.
authors.forename: Shilei
authors.initials: S
authors.lastname: Ding
authors.affiliation: Centre de Recherche du CHUM, Montreal, QC, Canada Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada.
authors.forename: Maxime
authors.initials: M
authors.lastname: Veillette
authors.affiliation: Centre de Recherche du CHUM, Montreal, QC, Canada Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Coutu
authors.affiliation: Centre de Recherche du CHUM, Montreal, QC, Canada Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada.
authors.forename: Jérémie
authors.initials: J
authors.lastname: Prévost
authors.affiliation: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
authors.forename: Louise
authors.initials: L
authors.lastname: Scharf
authors.affiliation: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Bjorkman
authors.affiliation: Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Guido
authors.initials: G
authors.lastname: Ferrari
authors.affiliation: Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Robinson
authors.affiliation: Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Stürzel
authors.affiliation: Department of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: Beatrice H
authors.initials: BH
authors.lastname: Hahn
authors.affiliation: Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Sauter
authors.affiliation: Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Kirchhoff
authors.affiliation: Institute of Human Virology and Department of Biochemistry and Molecular Biology of University of Maryland School of Medicine, Baltimore, Maryland, USA.
authors.forename: George K
authors.initials: GK
authors.lastname: Lewis
authors.affiliation: Institute of Human Virology and Department of Biochemistry and Molecular Biology of University of Maryland School of Medicine, Baltimore, Maryland, USA.
authors.forename: Marzena
authors.initials: M
authors.lastname: Pazgier
authors.affiliation: Centre de Recherche du CHUM, Montreal, QC, Canada Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada andres.finzi@umontreal.ca.
authors.forename: Andrés
authors.initials: A
authors.lastname: Finzi
mesh_terms: D000920:Antibody-Dependent Cell Cytotoxicity; D017124:Conserved Sequence; D015483:HIV Antibodies / Q000276:immunology*; D015699:HIV Envelope Protein gp120 / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans
chemical_list: D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120; C514793:gp120 protein, Human immunodeficiency virus 1