title: Experimental study of vein subvolution combined with neural stem cells to repair sciatic neurologic defects in rats.
abstract: This study aims to explore the effects of vein subvolution combined with neural stem cells on nerve regeneration. Animal model of sciatic nerve defects was established with SD rats. A total of 63 SD rats were divided into control group, vein subvolution group (treatment 1 group) and vein subvolution combined with neural stem cells group (treatment 2 group). The recovery of neurological function after 12 weeks was evaluated by nerve electrophysiological technique, histological observation and other methods. The recovery degree of sciatic nerve defect in treatment 2 group was better than that of other groups; The SFI values significantly decreased in treatment 2 group after 8 weeks; the regenerative nerve fiber numbers in treatment 2 group were significant higher than that of other groups; the recovery rates of treatment 1 and 2 groups were significant higher than that of control group. The effects of vein subvolution combined with neural stem cells on repairing peripheral nerve defects were better than that of vein subvolution method.
authors.affiliation: Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University No. 1 Youyi Road, Yuanjiagang of Yuzhong District of Chongqing, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Li
authors.affiliation: School of Public Health and Management, Hubei University of Medicine China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University No. 1 Youyi Road, Yuanjiagang of Yuzhong District of Chongqing, China.
authors.forename: Dianming
authors.initials: D
authors.lastname: Jiang
mesh_terms: D000818:Animals; D015153:Blotting, Western; D004195:Disease Models, Animal; D004594:Electrophysiology; D051379:Mice; D009416:Nerve Regeneration / Q000502:physiology*; D058953:Neural Stem Cells / Q000637:transplantation*; D059348:Peripheral Nerve Injuries / Q000601:surgery*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function; D012584:Sciatic Nerve / Q000293:injuries; D033581:Stem Cell Transplantation / Q000379:methods*; D014680:Veins / Q000637:transplantation*
keywords: Vein subvolution; neural stem cells; neurologic defect; tissue engineering