title: Durable response using regorafenib in an elderly patient with metastatic colorectal cancer: case report.
abstract: Regorafenib, an oral multikinase inhibitor, was approved in September 2012 by the US Food and Drug Administration for the treatment of patients with metastatic colorectal cancer. Since this time, however, few case reports outlining real-world usage have been published in the literature. Here, we detail the clinical history of an elderly woman with KRAS wild-type colon cancer who received regorafenib after prior treatment with other agents. We show that by employing dose modification strategies to address adverse events, this patient was able to remain on therapy for 11 months and achieve stable disease.
authors.affiliation: Division of Hematology-Oncology, University of California, Irvine, Orange, CA, USA.
authors.forename: Ronald
authors.initials: R
authors.lastname: Tang
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, University of California, Irvine, Orange, CA, USA.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Kain
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, University of California, Irvine, Orange, CA, USA.
authors.forename: June
authors.initials: J
authors.lastname: Herman
authors.affiliation: Division of Hematology-Oncology, University of California, Irvine, Orange, CA, USA.
authors.forename: Tara
authors.initials: T
authors.lastname: Seery
keywords: metastatic colorectal cancer; oral multikinase inhibitor; regorafenib