title: RNF2 E3 or Not to E3: Dual Roles of RNF2 Overexpression in Melanoma.
abstract: RNF2/RING1B is amplified and overexpressed in numerous tumors and contributes to tumorigenicity; however, the biologic importance is poorly understood. Surprisingly, the role of RNF2 in tumorigenesis and invasion can be separated into catalytically independent and catalytically dependent processes.
authors.affiliation: Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Charlestown, Massachusetts.
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Black
authors.affiliation: Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Charlestown, Massachusetts. jwhetstine@hms.harvard.edu.
authors.forename: Johnathan R
authors.initials: JR
authors.lastname: Whetstine
mesh_terms: D006801:Humans; D008545:Melanoma; D063150:Polycomb Repressive Complex 1; D044767:Ubiquitin-Protein Ligases
chemical_list: D063150:Polycomb Repressive Complex 1; D044767:Ubiquitin-Protein Ligases