title: Oxidative stress in multiple sclerosis: Central and peripheral mode of action.
abstract: Accumulating evidence suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis (MS). Reactive oxygen species (ROS), which if produced in excess lead to oxidative stress, have been implicated as mediators of demyelination and axonal damage in both MS and its animal models. One of the most studied cell populations in the context of ROS-mediated tissue damage in MS are macrophages and their CNS companion, microglia cells. However, and this aspect is less well appreciated, the extracellular and intracellular redox milieu is integral to many processes underlying T cell activation, proliferation and apoptosis. In this review article we discuss how oxidative stress affects central as well as peripheral aspects of MS and how manipulation of ROS pathways can potentially affect the course of the disease. It is our strong belief that the well-directed shaping of ROS pathways has the potential to ameliorate disease progression in MS.
authors.affiliation: Dept. of Pediatrics, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany. Electronic address: kohl@ukaachen.de.
authors.forename: Kim
authors.initials: K
authors.lastname: Ohl
authors.affiliation: Dept. of Pediatrics, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Tenbrock
authors.affiliation: Department of Anatomy II, Ludwig-Maximilians-University of Munich, 80336 Munich, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Kipp
mesh_terms: D006801:Humans; D009103:Multiple Sclerosis / Q000473:pathology* / Q000503:physiopathology; D009420:Nervous System / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology*
keywords: DMF; Neurodegeneration; Neuroprotection; Nrf2