title: SP-D, KL-6, and HTI-56 levels in children with mycoplasma pneumoniae pneumonia.
abstract: The study was aimed to evaluate the potential biomarkers from pulmonary surfactant protein D (SP-D), Krebs von den Lungen-6 (KL-6), and 56-kD a human type I protein (HTI-56) in serum and bronchoalveolar lavage fluid samples of children with Mycoplasma pneumoniae pneumonia. This retrospective study, self-controlled study enrolled 34 Chinese children with M. pneumoniae pneumonia. The levels of SP-D, KL-6, and HTI-56 in bronchoalveolar lavage fluid samples were assessed and compared between patients with unilateral lung infection and contralateral lungs without any abnormal findings. Significant differences in the levels of SP-D, KL-6, and HTI-56 were observed in infected bronchoalveolar lavage fluid samples compared with uninfected samples (all P<0.05); however, there was no correlation between the serum level of SP-D, KL-6, and HTI-56 and their levels in infected and uninfected bronchoalveolar lavage fluid samples (P>0.05).
  
  
  CONCLUSIONS
  The high levels of SP-D, KL-6, and HTI-56 in infected bronchoalveolar lavage fluid samples may reflect the injury of alveolar epithelium caused by M. pneumoniae. Instead of SP-D in uninfected bronchoalveolar lavage fluid samples obtained by invasive bronchoscopy, serum SP-D may serve as a convenient medium to distinguish lung infection caused by M. pneumoniae.
authors.affiliation: Department of Pediatric Pulmonology, Shanghai Children's Hospital, Shanghai Jiao Tong University Shanghai 200062, China.
authors.forename: Lin-Hua
authors.initials: LH
authors.lastname: Shu
authors.affiliation: Department of Pediatric Pulmonology, Shanghai Children's Hospital, Shanghai Jiao Tong University Shanghai 200062, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Lu
authors.affiliation: Department of Pediatrics, Shengjing Hospital of China Medical University Shenyang 110004, China.
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Han
authors.affiliation: Department of Biostatistics and Epidemiology, School of Public Health, China Medical University Shenyang 110001, China.
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Dong
mesh_terms: D000293:Adolescent; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D001999:Bronchoscopy; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D018396:Mucin-1 / Q000097:blood*; D009177:Mycoplasma pneumoniae / Q000472:pathogenicity*; D011019:Pneumonia, Mycoplasma / Q000097:blood* / Q000175:diagnosis / Q000382:microbiology; D011237:Predictive Value of Tests; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; C117055:HTI56 protein, human; C060192:MUC1 protein, human; D008565:Membrane Proteins; D018396:Mucin-1; D037663:Pulmonary Surfactant-Associated Protein D
keywords: Krebs von den Lungen-6; Mycoplasma pneumoniae pneumonia; bronchoalveolar lavage fluid; pulmonary surfactant protein D