title: Corticosteroids in Myositis and Scleroderma.
abstract: Idiopathic inflammatory myopathies (IIMs) involve inflammation of the muscles and are classified by the patterns of presentation and immunohistopathologic features on skin and muscle biopsy into 4 categories: dermatomyositis, polymyositis, inclusion body myositis, and immune-mediated necrotizing myopathy. Systemic corticosteroid (CS) treatment is the standard of care for IIM with muscle and organ involvement. The extracutaneous features of systemic sclerosis are frequently treated with CS; however, high doses have been associated with scleroderma renal crisis in high-risk patients. Although CS can be effective first-line agents, their significant side effect profile encourages concomitant treatment with other immunosuppressive medications to enable timely tapering.
authors.affiliation: Division of Rheumatology and Immunology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Postolova
authors.affiliation: Department of Dermatology, Stanford Hospital and Clinics, 450 Broadway Street, Pavilion C, Suite 242, Redwood City, CA 94063, USA.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Chen
authors.affiliation: Division of Rheumatology and Immunology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Division of Rheumatology, VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA. Electronic address: Shauwei@stanford.edu.
authors.forename: Lorinda
authors.initials: L
authors.lastname: Chung
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001706:Biopsy; D003882:Dermatomyositis / Q000175:diagnosis / Q000188:drug therapy; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D018482:Muscle, Skeletal / Q000473:pathology; D009220:Myositis / Q000175:diagnosis / Q000188:drug therapy*; D018979:Myositis, Inclusion Body / Q000175:diagnosis / Q000188:drug therapy; D017285:Polymyositis / Q000175:diagnosis / Q000188:drug therapy; D012595:Scleroderma, Systemic / Q000175:diagnosis / Q000188:drug therapy*; D012867:Skin / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones; D005938:Glucocorticoids; D007166:Immunosuppressive Agents
keywords: Corticosteroids; Glucocorticoids; Idiopathic inflammatory myopathies; Morphea; Myositis; Scleroderma; Systemic sclerosis