title: High PCA3 scores in urine correlate with poor-prognosis factors in prostate cancer patients.
abstract: BACKGROUND
  To improve the prediction of prostate cancer (PCA) risk and pathological type of PCA by non-invasive approaches before performing prostatic biopsy are the current challenges for the management of PCA. The aim of this present study was evaluate the clinical validity of prostate cancer associated 3 (PCA3) gene in the prediction of PCA and the correlations between the PCA3 level and prognostic factors.
  
  
  METHODS
  A total of 207 patients with suspected prostate cancer in Ningbo No. 2 hospital between June 2012 and July 2014 were enrolled in this study. All patients included underwent prostate biopsy under the direction of digital rectal examination (DRE) and were divided into PCA group and no evidence of malignancy (NEM) group according to the pathological diagnosis. We analyzed the association between PCA3 score and indicators of prognosis (Gleason score, percentage of positive cores and clinical stage) by multivariate analysis.
  
  
  RESULTS
  The levels of total prostate-specific antigen (t-PSA), prostate health index (PHI) and PCA3 score in patients with PCA were significantly higher than those in NEM group (P<0.05). In PCA group, PHI value and t-PSA were both factors significantly correlated with high Gleason score and clinical stage (P<0.05). A high PCA3 score in urine was significantly correlated with a high Gleason score, % positive cores and an advanced clinical stage (P<0.05).
  
  
  CONCLUSIONS
  PCA3 score might be one of useful diagnostic tools for determining suitable therapeutic programs for PCa and predicting the prognosis.
authors.affiliation: Department of Urinary Surgery, Ningbo No. 2 Hospital No. 41 Xibei Street, Ningbo 315000, Zhejiang Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: Department of Urinary Surgery, Ningbo No. 2 Hospital No. 41 Xibei Street, Ningbo 315000, Zhejiang Province, China.
authors.forename: Jiangyong
authors.initials: J
authors.lastname: Leng
authors.affiliation: Department of Urinary Surgery, Ningbo No. 2 Hospital No. 41 Xibei Street, Ningbo 315000, Zhejiang Province, China.
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Shao
authors.affiliation: Department of Urinary Surgery, Ningbo No. 2 Hospital No. 41 Xibei Street, Ningbo 315000, Zhejiang Province, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Wang
keywords: PCA3 score; Prostate cancer; prognosis