title: Two new compounds from Xanthium strumarium.
abstract: One new lignan, fructusol A (1), and one new thiazine derivative, 2-hydroxy-xanthiazone (2), along with eight known ones, were isolated from the seeds of Xanthium strumarium. The structures of new compounds were elucidated on the basis of extensive spectroscopic methods. Meanwhile, compounds 1-3 were tested for their antifungal activities against Candida albicans (ATCC 10231) in vitro. No one showed obvious inhibitions (MIC90 > 128 μg/ml).
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.|b University of Chinese Academy of Sciences , Beijing 100049 , China.
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Yin
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Xue
authors.initials: X
authors.lastname: Bai
authors.affiliation: c School of Pharmaceutical Sciences, South-Central University for Nationalities , Wuhan 430074 , China.
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Ze-Jun
authors.initials: ZJ
authors.lastname: Dong
authors.affiliation: c School of Pharmaceutical Sciences, South-Central University for Nationalities , Wuhan 430074 , China.
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry; D013843:Thiazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031210:Xanthium / Q000737:chemistry*
chemical_list: C000609835:2-hydroxyxanthiazone; D000935:Antifungal Agents; D017705:Lignans; D013843:Thiazines; C000609834:fructusol A
keywords: 2-hydroxy-xanthiazone; Xanthium strumarium; antifungal activities; fructusol A