title: A case report of suspected hepatopulmonary syndrome secondary to ductal plate malformation with chronic active hepatitis in a dog.
abstract: Hepatopulmonary syndrome (HPS) is a respiratory complication of hepatic disease, that is well recognized in humans and defined by the presence of 1) liver disease, 2) hypoxemia and/or high alveolar-arterial oxygen gradient (AaDO2) and 3) intrapulmonary vasodilatation. The present report describes a similar case of HPS in a dog. A six-month-old Papillon was diagnosed with ductal plate malformation with chronic active hepatitis and showed progressive increases in AaDO2 over the course of the following six months. The presence of intrapulmonary vasodilatation was confirmed by agitated saline contrast transthoracic echocardiography. Also, the absence of congenital cardiac defect was confirmed by transthoracic echocardiography. From these results, we suspected that this dog had HPS. This is the first description of suspected canine HPS.
authors.affiliation: Veterinary Teaching Hospital, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Shidow
authors.initials: S
authors.lastname: Torisu
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Hagio
authors.forename: Ryoji
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: Shinya
authors.initials: S
authors.lastname: Mizutani
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Naganobu
mesh_terms: D000818:Animals; D001653:Bile Ducts, Intrahepatic / Q000002:abnormalities* / Q000000981:diagnostic imaging; D004285:Dogs; D017548:Echocardiography, Transesophageal / Q000662:veterinary; D005260:Female; D006521:Hepatitis, Chronic / Q000150:complications / Q000000981:diagnostic imaging / Q000662:veterinary*; D020065:Hepatopulmonary Syndrome / Q000000981:diagnostic imaging / Q000209:etiology / Q000662:veterinary*; D008099:Liver / Q000473:pathology; D014463:Ultrasonography