title: New treatment models for compulsive disorders.
abstract: Obsessive compulsive disorder (OCD) as well as related disorders such as body dysmorphic disorder, tic disorder, and trichotillomania are all common and often debilitating. Although treatments are available, more effective approaches to these problems are needed. Thus this review article presents what is currently known about OCD and related disorders and suggests that understanding OCD more broadly as a compulsive disorder may allow for more effective treatment options. Toward that goal, the review presents new models of psychopharmacology and psychotherapy, as well as new brain stimulation strategies. Treatment advances, grounded in the neuroscience, have promise in advancing treatment response for OCD as well as other disorders of compulsivity.
authors.affiliation: Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Pritzker School of Medicine, 5841 S. Maryland Avenue, MC 3077, Chicago, IL 60637, USA. Electronic address: jongrant@uchicago.edu.
authors.forename: Jon E
authors.initials: JE
authors.lastname: Grant
authors.affiliation: Highly Specialized OCD and BDD Services, Hertfordshire Partnership University NHS Foundation Trust and University of Hertfordshire, UK.
authors.forename: Naomi
authors.initials: N
authors.lastname: Fineberg
authors.affiliation: Department of Psychiatry and Behavioural Neurosciences, McMaster University and MacAnxiety Research Centre, Hamilton, Ontario, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: van Ameringen
authors.affiliation: Utrecht University and Altrecht Academic Anxiety Disorders Center, Utrecht, The Netherlands.
authors.forename: Danielle
authors.initials: D
authors.lastname: Cath
authors.affiliation: Innova Research Centre, Mental Health Care Institute GGZ Centraal, Ermelo, The Netherlands.
authors.forename: Henny
authors.initials: H
authors.lastname: Visser
authors.affiliation: Department of Psychology, Tel Aviv University, Tel Aviv, Israel; Department of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Lior
authors.initials: L
authors.lastname: Carmi
authors.affiliation: Department of Psychiatry and Behavioral Sciences UC Davis Health System, Albert Einstein College of Medicine and Montefiore Medical Center, Sacramento, CA, USA.
authors.forename: Stefano
authors.initials: S
authors.lastname: Pallanti
authors.affiliation: Department of Psychiatry, Albert Einstein Medical School, Montefiore Medical Center, New York City, NY, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Hollander
authors.affiliation: Department of Psychiatry and EMGO(+) Institute, VU-University Medical Centre and GGZ ingest, Amsterdam, The Netherlands.
authors.forename: Anton J L M
authors.initials: AJ
authors.lastname: van Balkom
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D035843:Biomedical Research / Q000639:trends; D057215:Body Dysmorphic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy; D000072466:Cognitive Remediation; D003131:Combined Modality Therapy / Q000639:trends; D003192:Compulsive Behavior / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D003193:Compulsive Personality Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D046690:Deep Brain Stimulation / Q000639:trends; D015507:Drugs, Investigational / Q000627:therapeutic use*; D006184:Habits; D006801:Humans; D008959:Models, Neurological; D009420:Nervous System / Q000187:drug effects / Q000503:physiopathology; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D011613:Psychotherapy / Q000639:trends; D009626:Terminology as Topic; D035703:Therapies, Investigational / Q000639:trends; D050781:Transcranial Magnetic Stimulation / Q000639:trends; D014256:Trichotillomania / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy
chemical_list: D014150:Antipsychotic Agents; D015507:Drugs, Investigational
keywords: Compulsivity; Obsession; Pharmacotherapy; Psychotherapy