title: Antiviral Drug-Resistance Typing Reveals Compartmentalization and Dynamics of Acyclovir-Resistant Herpes Simplex Virus Type-2 (HSV-2) in a Case of Neonatal Herpes.
abstract: A neonate suffering from herpes simplex virus type 2 disease with central nervous system involvement developed an early recurrence under acyclovir therapy. Isolates from the cerebrospinal fluid and skin lesions were acyclovir resistant, while viruses from blood and trachea were not. Acyclovir combined with foscavir followed by long-term suppressive acyclovir therapy supported normal neurological development.
authors.affiliation: Neonatal Intensive Care Unit, Centre Hospitalier de Luxembourg.
authors.forename: Manon
authors.initials: M
authors.lastname: Bache
authors.affiliation: Laboratory of Virology and Chemotherapy.
authors.forename: Graciela
authors.initials: G
authors.lastname: Andrei
authors.affiliation: Neonatal Intensive Care Unit, Centre Hospitalier de Luxembourg.
authors.forename: Lutz
authors.initials: L
authors.lastname: Bindl
authors.affiliation: Neonatal Intensive Care Unit, Centre Hospitalier de Luxembourg.
authors.forename: Léon
authors.initials: L
authors.lastname: Bofferding
authors.affiliation: Neonatal Intensive Care Unit, Centre Hospitalier de Luxembourg.
authors.forename: Jean
authors.initials: J
authors.lastname: Bottu
authors.affiliation: Neonatal Intensive Care Unit, Centre Hospitalier de Luxembourg.
authors.forename: Christine
authors.initials: C
authors.lastname: Géron
authors.affiliation: Neonatal Intensive Care Unit, Centre Hospitalier de Luxembourg.
authors.forename: Christoph
authors.initials: C
authors.lastname: Neuhäuser
authors.affiliation: Laboratory of Virology and Chemotherapy.
authors.forename: Sarah
authors.initials: S
authors.lastname: Gillemot
authors.affiliation: Laboratory of Immunobiology, Rega Institute for Medical Research, Leuven, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Fiten
authors.affiliation: Laboratory of Immunobiology, Rega Institute for Medical Research, Leuven, Belgium.
authors.forename: Ghislain
authors.initials: G
authors.lastname: Opdenakker
authors.affiliation: Laboratory of Virology and Chemotherapy.
authors.forename: Robert
authors.initials: R
authors.lastname: Snoeck
keywords: acyclovir resistance; neonatal HSV; virus compartmentalization