title: Squamous cell carcinoma resulting from chronic osteomyelitis: a retrospective study of 8 cases.
abstract: BACKGROUND
  Squamous cell carcinoma is a severe malignant tumor but was rare in the chronic osteomyelitis. The purpose of this study was to present the results from a retrospective study the cases of squamous cell carcinoma arising from chronic osteomyelitis.
  
  
  METHODS
  Between 1974 and 2010, eight cases of squamous cell carcinoma after chronic osteomyelitis were treated. The patients had an average age of 55 years (range 45 to 66 years), with a male predominance (6 men and 2 woman). We analyzed the time up to cancerization, localization and histopathological types of the carcinoma, and types and results of the treatment.
  
  
  RESULTS
  The mean delay between the initial injury and the diagnosis of malignant transformation was 28 years (range 8 to 50 years). The carcinoma resulted from tibia osteomyelitis in six cases, femur in one case and ankle in one case. The pathological examination showed two cases of a well-differentiated squamous cell carcinoma with bone invasion and six cases of invasive squamous cell carcinoma. Curative amputation was performed in all patients but one who refused. No recurrence or metastasis occurred during follow-up time.
  
  
  CONCLUSIONS
  Amputation appears to be an effective treatment method in squamous carcinoma secondary to chronic osteomyelitis.
authors.affiliation: Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, China.
authors.forename: Qinghu
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, China.
authors.forename: Haomin
authors.initials: H
authors.lastname: Cui
authors.affiliation: Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, China.
authors.forename: Jinlei
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
mesh_terms: D000368:Aged; D000671:Amputation, Surgical; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000150:complications / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
keywords: Osteomyelitis; amputation; epithelial neoplasms; squamous cell carcinoma