title: New mannose derivatives: The tetrazole analogue of mannose-6-phosphate as angiogenesis inhibitor.
abstract: Two novel compounds with mannose-derived structure, bearing a tetrazole (compound 3) and a sulfone group (compound 4) in terminal position, have been prepared from methyl α-d-mannopyranoside in reduced number of steps. The angiogenic activity of 3 and 4 has been screened using the chick chorioallantoic membrane (CAM) method. Tetrazole 3 has been identified to possess a promising bioactivity, being identified as angiogenesis inhibitor, with 68% of neovascular vessels when compared to control (PBS).
authors.affiliation: Université de Montpellier, Place Eugène Bataillon, 34095 Montpellier, France. Electronic address: catalinagurgui@yahoo.co.uk.
authors.forename: Cătălina
authors.initials: C
authors.lastname: Ionescu
authors.affiliation: Université de Montpellier, Place Eugène Bataillon, 34095 Montpellier, France.
authors.forename: Simona
authors.initials: S
authors.lastname: Sippelli
authors.affiliation: GMCM UMR 6626, Campus de Beaulieu, 35042 Rennes Cedex, France.
authors.forename: Loïc
authors.initials: L
authors.lastname: Toupet
authors.affiliation: Université de Montpellier, Place Eugène Bataillon, 34095 Montpellier, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Barragan-Montero
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D002645:Chickens; D049033:Chorioallantoic Membrane / Q000098:blood supply / Q000187:drug effects; D054879:Halogenation; D008360:Mannosephosphates / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000737:chemistry / Q000494:pharmacology; D013777:Tetrazoles / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D020533:Angiogenesis Inhibitors; D008360:Mannosephosphates; D013450:Sulfones; D013777:Tetrazoles; C045574:1H-tetrazole; C027693:mannose-6-phosphate
keywords: Carboxylic acid; Iodination; Mannose-6-phosphate analogues; Sulfone; Tetrazole