title: Role of E-selectin for diagnosis of myocardial injury in children of age up to 14 years.
abstract: BACKGROUND
  Effects of myocardial injury on E-selectin remain unclear. Thus, we investigated the diagnostic value of E-selectin for myocardial injury in children of no more than 14 years of age, which determined the scoring method of myocardial injury.
  
  
  METHODS
  In this prospective study, plasma E-selectin, cardiac troponin I (cTnI) and creatine kinase isoenzyme MB (CK-MB) concentrations in pediatric patients with myocardial injury (myocardial injury group, n=85) were measured. The control group comprised 80 patients without myocardial injury, and the case-control study method was selected at the same time. The definition of cardiac injury was based on cTnI and CK-MB (with or possibly without abnormal ECG evidence). Diagnostic value of E-selectin for myocardial injury was determined by analyzing receiver operating characteristic (ROC) curves.
  
  
  RESULTS
  The differences between the two groups were of statistical significance (P<0.001). For the 85 patients with myocardial injury, the area under the ROC curve (AUC) value for plasma E-selectin levels was 0.945 with a 95% CI of 0.899-0.991 and the optimal diagnostic cut-off value 29.67 ng/ml (positive likelihood ratio (positive LR=72.5); AUC value for plasma cTnI level was 0.848 with a 95% CI: 0.737-0.960 and the optimal diagnostic cut-off value was 0.155 µg/L (positive LR=12.3); AUC value for plasma CK-MB levels was 0.946 with a 95% CI: 0.903-0.989 and the optimal diagnostic cut-off value 24.26 IU/L (positive LR=72.5).
  
  
  CONCLUSIONS
  E-selectin is more effective than cTnI in diagnosing myocardial injury as an important biological marker of myocardial injury- an important index of pediatric cardiac injury score.
authors.affiliation: The Affiliated Shunde Women and Children Hospital of Jinan University Shunde 528300, Guangdong, P. R. China.
authors.forename: Shao-Hu
authors.initials: SH
authors.lastname: Jiang
authors.affiliation: The Affiliated Shunde Women and Children Hospital of Jinan University Shunde 528300, Guangdong, P. R. China.
authors.forename: Chun-Wang
authors.initials: CW
authors.lastname: Lin
authors.affiliation: The Affiliated Shunde Women and Children Hospital of Jinan University Shunde 528300, Guangdong, P. R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wen
authors.affiliation: The Affiliated Shunde Women and Children Hospital of Jinan University Shunde 528300, Guangdong, P. R. China.
authors.forename: Ming-Hong
authors.initials: MH
authors.lastname: Deng
authors.affiliation: The Affiliated Shunde Women and Children Hospital of Jinan University Shunde 528300, Guangdong, P. R. China.
authors.forename: Yan-Na
authors.initials: YN
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D000367:Age Factors; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D052279:Creatine Kinase, MB Form / Q000097:blood; D019040:E-Selectin / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006331:Heart Diseases / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D019210:Troponin I / Q000097:blood
chemical_list: D015415:Biomarkers; D019040:E-Selectin; C546936:SELE protein, human; D019210:Troponin I; D052279:Creatine Kinase, MB Form
keywords: E-selectin; children; diagnostic value; myocardial injury; score