title: Copper(I)-Catalyzed Interrupted Click Reaction: Synthesis of Diverse 5-Hetero-Functionalized Triazoles.
abstract: The 5-heterofunctionalized triazoles are important scaffolds in bioactive compounds, but current click reactions (CuAAC) cannot produce these core structures. A copper(I)-catalyzed interrupted click reaction to access diverse 5-functionalized triazoles is reported. Various 5-amino-, thio-, and selenotriazoles were readily assembled in one step in high yields. The reaction proceeds under mild conditions with complete regioselectivity. It also features a broad substrate scope and good functional group compatibility.
authors.affiliation: Key Lab for Colloid and Interface Chemistry of Education Ministry, Department of Chemistry, Shandong University, No. 27 South Shanda Road, Jinan, 250100 (China) http://opcl.sdu.edu.cn/Teacher.aspx?tid=4.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Wang
authors.affiliation: Key Lab for Colloid and Interface Chemistry of Education Ministry, Department of Chemistry, Shandong University, No. 27 South Shanda Road, Jinan, 250100 (China) http://opcl.sdu.edu.cn/Teacher.aspx?tid=4.
authors.forename: Xianglong
authors.initials: X
authors.lastname: Peng
authors.affiliation: Key Lab for Colloid and Interface Chemistry of Education Ministry, Department of Chemistry, Shandong University, No. 27 South Shanda Road, Jinan, 250100 (China) http://opcl.sdu.edu.cn/Teacher.aspx?tid=4.
authors.forename: Fang
authors.initials: F
authors.lastname: Wei
authors.affiliation: Key Lab for Colloid and Interface Chemistry of Education Ministry, Department of Chemistry, Shandong University, No. 27 South Shanda Road, Jinan, 250100 (China) http://opcl.sdu.edu.cn/Teacher.aspx?tid=4.
authors.forename: Chen-Ho
authors.initials: CH
authors.lastname: Tung
authors.affiliation: Key Lab for Colloid and Interface Chemistry of Education Ministry, Department of Chemistry, Shandong University, No. 27 South Shanda Road, Jinan, 250100 (China) http://opcl.sdu.edu.cn/Teacher.aspx?tid=4. xuzh@sdu.edu.cn.|State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032 (P.R. China). xuzh@sdu.edu.cn.
authors.forename: Zhenghu
authors.initials: Z
authors.lastname: Xu
keywords: aminations; click reactions; sulfenylation; triazoles