title: Modulation of acute transient exercise-induced hypertension after oral administration of four angiotensin-converting enzyme inhibitors in normotensive horses.
abstract: Changes in blood pressure (BP) during acute hypertension in response to angiotensin-converting enzyme inhibitors (ACEIs) have not been investigated in normotensive horses. In this study, six healthy horses were subjected to five trials, consisting in a treadmill exercise workload of 8 m/s for 1 min, 2 h after oral administration (PO) of placebo (0 mg/kg), enalapril (2.0 mg/kg), quinapril (1.0 mg/kg), ramipril (0.2 mg/kg) or benazepril (0.5 mg/kg). Serum angiotensin converting enzyme (ACE) activity was measured and systolic (SBP) and diastolic (DBP) blood pressures were recorded at rest (R), 2 h after placebo or ACEI administration (pre-E) and within the first 20 s after exercise (post-E). Mean maximum serum ACE inhibition 2 h after PO administration was 4.8% (placebo), 39.4% (enalapril), 46.4% (quinapril), 55.0% (ramipril) and 71.68% (benazepril). There were no significant differences in serum ACE inhibition between enalapril and quinapril. SBP and DBP at times R and pre-E were not different in any of the five trials. In response to exercise, SBP increased by 67.6% (placebo), 52.7% (enalapril), 43.1% (quinapril), 26.6% (ramipril) and 4.2% (benazepril). In response to exercise, DBP increased by 20.6, 13.2, 11.7, 16.6 and 3.7% after placebo, enalapril, quinapril, ramipril and benazepril administration, respectively. Serum ACE activity changed during exercise, but statistical significance was not achieved. In conclusion, administration of PO benazepril at a dose of 0.5 mg/kg modulated physiological hypertension induced by exercise in horses that were otherwise normotensive.
authors.affiliation: Department of Animal Medicine and Surgery, School of Veterinary Medicine, University of Córdoba, Córdoba, Spain; Equine Sport Medicine Centre, CEMEDE, School of Veterinary Medicine, University of Córdoba, Córdoba 14004, Spain. Electronic address: pv1mujua@uco.es.
authors.forename: Ana
authors.initials: A
authors.lastname: Muñoz
authors.affiliation: Equine Sport Medicine Centre, CEMEDE, School of Veterinary Medicine, University of Córdoba, Córdoba 14004, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Esgueva
authors.affiliation: Equine Sport Medicine Centre, CEMEDE, School of Veterinary Medicine, University of Córdoba, Córdoba 14004, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Gómez-Díez
authors.affiliation: Department of Pharmacology, Toxicology, and Legal and Forensic Medicine, School of Veterinary Medicine, University of Córdoba, Córdoba, Spain.
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Serrano-Caballero
authors.affiliation: Equine Sport Medicine Centre, CEMEDE, School of Veterinary Medicine, University of Córdoba, Córdoba 14004, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Castejón-Riber
authors.affiliation: Department of Pharmacology, Toxicology, and Legal and Forensic Medicine, School of Veterinary Medicine, University of Córdoba, Córdoba, Spain.
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Serrano-Rodríguez
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood*; D000284:Administration, Oral; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy* / Q000209:etiology; D006736:Horses; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology / Q000821:virology*; D008297:Male; D010805:Physical Conditioning, Animal
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D000110:Acetylcholinesterase
keywords: Angiotensin-converting enzyme inhibitors; Blood pressure; Equine; Exercise; Hypertension