title: A mass spectrometric insight into the origins of benign gynecological disorders.
abstract: Applications of mass spectrometry (MS) are rapidly expanding and encompass molecular and cellular biology. MS aids in the analysis of in vivo global molecular alterations, identifying potential biomarkers which may improve diagnosis and treatment of various pathologies. MS has added new dimensionality to medical research. Pioneering gynecologists now study molecular mechanisms underlying female reproductive pathology with MS-based tools. Although benign gynecologic disorders including endometriosis, adenomyosis, leiomyoma, and polycystic ovarian syndrome (PCOS) carry low mortality rates, they cause significant physical, mental, and social detriments. Additionally, some benign disorders are unfortunately associated with malignancies. MS-based technology can detect malignant changes in formerly benign proteomes and metabolomes with distinct advantages of speed, sensitivity, and specificity. We present the use of MS in proteomics and metabolomics, and summarize the current understanding of the molecular pathways concerning female reproductive anatomy. Highlight discoveries of novel protein and metabolite biomarkers via MS-based technology, we underscore the clinical application of these techniques in the diagnosis and management of benign gynecological disorders. © 2015 Wiley Periodicals, Inc. Mass Spec Rev 36:450-470, 2017.
authors.affiliation: Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.|Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
authors.forename: Huiliang
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Emergency Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, 19107.
authors.forename: Wayne Bond
authors.initials: WB
authors.lastname: Lau
authors.affiliation: Department of Surgery, Emergency Medicine, Kaiser Santa Clara Medical Center, Affiliate of Stanford University, Stanford, CA, 94305.
authors.forename: Bonnie
authors.initials: B
authors.lastname: Lau
authors.affiliation: The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xuan
authors.affiliation: Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
authors.forename: Shengtao
authors.initials: S
authors.lastname: Zhou
authors.affiliation: The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
authors.forename: Linjie
authors.initials: L
authors.lastname: Zhao
authors.affiliation: College of Biological Sciences, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
authors.forename: Zhongyue
authors.initials: Z
authors.lastname: Luo
authors.affiliation: College of Biological Sciences, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Lin
authors.affiliation: College of Biological Sciences, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Ren
authors.affiliation: Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
authors.affiliation: The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Wei
mesh_terms: D062788:Adenomyosis / Q000175:diagnosis / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D004715:Endometriosis / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D005831:Genital Diseases, Female / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis / Q000378:metabolism; D013058:Mass Spectrometry / Q000379:methods*; D055442:Metabolome; D055432:Metabolomics / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000378:metabolism; D020543:Proteome / Q000032:analysis / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000378:metabolism
chemical_list: D015415:Biomarkers; D020543:Proteome
keywords: benign gynecological disorders; mass spectrometry; metabolomics; proteomics