title: A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study.
abstract: Astroblastoma is a rare neuroepithelial neoplasm of unknown origin, usually occurring in children and young adults. Here we report a case of astroblastoma with uncommon features in an 18-year-old female. The tumor was a well-circumscribed cystic and solid mass with marked gadolinium enhancement in the right frontal lobe. Cytological examination showed polarized monopolar cells with diminished cohesiveness. Tumor cells possessed eccentric round to oval nuclei with abundant eosinophilic cytoplasm, sometimes having cytoplasmic processes. Histopathologically, the tumor showed perivascular pseudorosettes with prominent vascular sclerosis. Foam cells were frequently infiltrated around blood vessels and among tumor cells. In some areas, a solid growth pattern of plump tumor cells with abundant inclusion-like eosinophilic cytoplasm showing rhabdoid appearance was observed. The immunohistochemical study revealed strong and diffuse positivity for vimentin and epithelial membrane antigen. Tumor cells were focally positive for glial fibrillary acidic protein and cytokeratin AE1/AE3. Nuclear immunoreactivity for INI1 protein was evident. The Ki-67 labeling index was 10.8%. This tumor was finally diagnosed as low-grade astroblastoma and the patient had no evidence of recurrence without postoperative radiotherapy or chemotherapy during the last 6 months of follow-up. This report describes novel cytological, histopathological, and immunohistochemical features of the rare tumor.
authors.affiliation: Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo, 060-8638, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Yuzawa
authors.affiliation: Department of Translational Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.|Translational Research Laboratory, Hokkaido University Hospital, Clinical Research and Medical Innovation Center, Sapporo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishihara
authors.affiliation: Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo, 060-8638, Japan.
authors.forename: Mishie
authors.initials: M
authors.lastname: Tanino
authors.affiliation: Department of Translational Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.|Translational Research Laboratory, Hokkaido University Hospital, Clinical Research and Medical Innovation Center, Sapporo, Japan.
authors.forename: Taichi
authors.initials: T
authors.lastname: Kimura
authors.affiliation: Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo, 060-8638, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Moriya
authors.affiliation: Sapporo Azabu Neurosurgical Hospital, Sapporo, Japan.|Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Yuuta
authors.initials: Y
authors.lastname: Kamoshima
authors.affiliation: Higashi Tokushukai Hospital, Sapporo, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nagashima
authors.affiliation: Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo, 060-8638, Japan. tanaka@med.hokudai.ac.jp.|Department of Translational Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. tanaka@med.hokudai.ac.jp.
authors.forename: Shinya
authors.initials: S
authors.lastname: Tanaka
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D005260:Female; D005500:Follow-Up Studies; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007633:Keratins / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D018396:Mucin-1 / Q000032:analysis; D060787:Neoplasm Grading; D018302:Neoplasms, Neuroepithelial / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D018335:Rhabdoid Tumor; D016896:Treatment Outcome; D014746:Vimentin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen; D018396:Mucin-1; D014746:Vimentin; D007633:Keratins
keywords: Astroblastoma; Cytology; Foam cell; Rhabdoid