title: STAT1 activation in association with JAK2 exon 12 mutations.
authors.affiliation: Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, UK Department of Haematology, Addenbrooke's Hospital, UK Department of Haematology, University of Cambridge, Cambridge, UK.
authors.forename: Anna L
authors.initials: AL
authors.lastname: Godfrey
authors.affiliation: Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, UK Department of Haematology, University of Cambridge, Cambridge, UK.
authors.forename: Edwin
authors.initials: E
authors.lastname: Chen
authors.affiliation: Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, UK Department of Haematology, University of Cambridge, Cambridge, UK.
authors.forename: Charles E
authors.initials: CE
authors.lastname: Massie
authors.affiliation: Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, UK Department of Haematology, University of Cambridge, Cambridge, UK.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Silber
authors.affiliation: Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, UK Department of Haematology, University of Cambridge, Cambridge, UK.
authors.forename: Francesca
authors.initials: F
authors.lastname: Pagano
authors.affiliation: Hematology Department, Hospital del Mar-IMIM, Barcelona, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Bellosillo
authors.affiliation: Department of Experimental and Clinical Medicine, University of Florence and Azienda Ospedaliera Universitaria Careggi, Florence, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Guglielmelli
authors.affiliation: Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
authors.forename: Claire N
authors.initials: CN
authors.lastname: Harrison
authors.affiliation: Department of Haematology, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: John T
authors.initials: JT
authors.lastname: Reilly
authors.affiliation: University Hospital of Ulm, Department of Internal Medicine III, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Stegelmann
authors.affiliation: Institut Bergonie, Department of Hematology, Bordeaux, France.
authors.forename: Fontanet
authors.initials: F
authors.lastname: Bijou
authors.affiliation: Laboratoire d'Hematologie, CHU de Bordeaux and Laboratorie Hematopoiese Leucemique et Cibles Thérapeutiques, INSERM U 1035, Universite Bordeaux Segalen, Bordeaux, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Lippert
authors.affiliation: University of Bordeaux, Etablissement Français du Sang, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Boiron
authors.affiliation: University Hospital of Ulm, Department of Internal Medicine III, Germany.
authors.forename: Konstanze
authors.initials: K
authors.lastname: Döhner
authors.affiliation: Department of Experimental and Clinical Medicine, University of Florence and Azienda Ospedaliera Universitaria Careggi, Florence, Italy.
authors.forename: Alessandro M
authors.initials: AM
authors.lastname: Vannucchi
authors.affiliation: Hematology Department, Hospital del Mar-IMIM, Barcelona, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Besses
authors.affiliation: Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, UK Department of Haematology, Addenbrooke's Hospital, UK Department of Haematology, University of Cambridge, Cambridge, UK arg1000@cam.ac.uk.
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Green
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019943:Amino Acid Substitution; D005091:Exons; D005260:Female; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D050794:STAT1 Transcription Factor / Q000235:genetics / Q000378:metabolism; D013920:Thrombocythemia, Essential / Q000235:genetics / Q000378:metabolism / Q000473:pathology
chemical_list: D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; C507924:JAK2 protein, human; D053614:Janus Kinase 2
keywords: JAK2 exon 12; STAT1; activation; mutations