title: Thoracoscopic Lung Suffusion.
abstract: The lung is a common site of metastatic disease, which may be the only measurable malignancy in some patients. Unfortunately, because of the invasiveness of previous techniques and the fragility of these target organs, many attempts at regional lung therapies have not become that popular. Accordingly, a method for thoracoscopic vascular control to enable permeation of the lung with agents was developed and termed suffusion to distinguish it from earlier methods. This article describes the preclinical work supporting lung suffusion and our early human experience.
authors.affiliation: Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA. Electronic address: todd.demmy@cinj.rutgers.edu.
authors.forename: Todd L
authors.initials: TL
authors.lastname: Demmy
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D007432:Intraoperative Period; D008175:Lung Neoplasms / Q000628:therapy*; D011013:Pneumonectomy / Q000379:methods*; D013906:Thoracoscopy / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents
keywords: Isolated lung perfusion; Lung cancer; Minimally invasive surgery; Pulmonary suffusion; Regional chemotherapy