title: Association of COL1A1 polymorphisms with osteoporosis: a meta-analysis of clinical studies.
abstract: OBJECTIVE
  To conduct a meta-analysis of all association studies on two of the collagen 1 alpha 1 (COL1A1) gene polymorphisms, the -1997G/T (rs1107946) and the -1663indelT (rs2412298) polymorphisms and osteoporosis/BMD and fracture.
  
  
  METHODS
  PubMed/Medline and Web of Knowledge were searched for relevant association studies published in English. Pooled OR and its corresponding 95% CI or pooled MD and its corresponding 95% CI was calculated with the Cochrane Review Manager (Revman, version 5.2) using a random-effect or a fixed effect model.
  
  
  RESULTS
  No significant association between the -1997G/T polymorphism and Lumbar Spine (LS) and Femoral Neck (FN) BMD except for the Caucasian subpopulation wherein subjects with the T allele of the -1997G/T polymorphism was associated with significantly higher LS BMD. Our analysis did reveal that women, especially postmenopausal or perimenopausal women with the GG genotype, had significantly higher Total Hip (TH) BMD than those with the GT. Additionally, our meta-analysis did not show significant association between the -1997G/T polymorphism and risk of fracture, between the -1663indelT polymorphism and LS BMD in postmenopausal or perimenopausal women, or between the -1663indelT polymorphism and the risk of fracture.
  
  
  CONCLUSIONS
  Our results suggested the possibility of the COL1A1 -1997G/T and the -1663indelT polymorphisms individually playing very little role in osteoporosis and fracture, although more studies are needed especially for the analysis of association between these two polymorphisms and fracture. Haplotype studies may become one important future direction of study to further elucidate whether and how various COL1A1 polymorphisms affect bone health, osteoporosis and fracture.
authors.affiliation: Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-Sen University Shi Pai, Tian He District, No.600, Tianhe Road, Guangzhou 510630, Guangdong, People's Republic of China.
authors.forename: Peigen
authors.initials: P
authors.lastname: Xie
authors.affiliation: Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-Sen University Shi Pai, Tian He District, No.600, Tianhe Road, Guangzhou 510630, Guangdong, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-Sen University Shi Pai, Tian He District, No.600, Tianhe Road, Guangzhou 510630, Guangdong, People's Republic of China.
authors.forename: Liangming
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-Sen University Shi Pai, Tian He District, No.600, Tianhe Road, Guangzhou 510630, Guangdong, People's Republic of China.
authors.forename: Ruiqiang
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-Sen University Shi Pai, Tian He District, No.600, Tianhe Road, Guangzhou 510630, Guangdong, People's Republic of China.
authors.forename: Bu
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-Sen University Shi Pai, Tian He District, No.600, Tianhe Road, Guangzhou 510630, Guangdong, People's Republic of China.
authors.forename: Jianwen
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-Sen University Shi Pai, Tian He District, No.600, Tianhe Road, Guangzhou 510630, Guangdong, People's Republic of China.
authors.forename: Limin
authors.initials: L
authors.lastname: Rong
keywords: -1663indelT; -1997G/T; COL1A1; bone mineral density; fracture; osteoporosis; polymorphism