title: Cellular immune response in intraventricular experimental neurocysticercosis.
abstract: Neurocysticercosis (NCC) is considered a neglected parasitic infection of the human central nervous system. Its pathogenesis is due to the host immune response, stage of evolution and location of the parasite. The aim of this study was to evaluate the in situ and systemic immune response through cytokines dosage (IL-4, IL-10, IL-17 and IFN-γ) as well as the local inflammatory response of the experimental NCC with Taenia crassiceps. The in situ and systemic cellular and inflammatory immune response were evaluated through the cytokines quantification at 7, 30, 60 and 90 days after inoculation and histopathological analysis. All cysticerci were found within the cerebral ventricles. There was a discrete intensity of inflammatory cells of mixed immune profile, polymorphonuclear and mononuclear cells, at the beginning of the infection and predominance of mononuclear cells at the end. The systemic immune response showed a significant increase in all the analysed cytokines and predominance of the Th2 immune profile cytokines at the end of the infection. These results indicate that the location of the cysticerci may lead to ventriculomegaly. The acute phase of the infection showed a mixed Th1/Th17 profile accompanied by high levels of IL-10 while the late phase showed a Th2 immune profile.
authors.affiliation: Department of Microbiology,Immunology,Parasitology and Pathology,Tropical Pathology and Public Health Institute,Federal University of Goias,- Rua 235 S/N,Setor Universitário,74605-050,Goiânia,Goiás,Brazil.
authors.forename: Vania B L
authors.initials: VB
authors.lastname: Moura
authors.affiliation: Tropical Pathology and Public Health Post-graduation Programme,Tropical Pathology and Public Health Institute,Federal University of Goias,- Rua 235 S/N,Setor Universitário,74605-050,Goiânia,Goiás,Brazil.
authors.forename: Sarah B
authors.initials: SB
authors.lastname: Lima
authors.affiliation: Tropical Pathology and Public Health Post-graduation Programme,Tropical Pathology and Public Health Institute,Federal University of Goias,- Rua 235 S/N,Setor Universitário,74605-050,Goiânia,Goiás,Brazil.
authors.forename: Hidelberto
authors.initials: H
authors.lastname: Matos-Silva
authors.affiliation: Department of Microbiology,Immunology,Parasitology and Pathology,Tropical Pathology and Public Health Institute,Federal University of Goias,- Rua 235 S/N,Setor Universitário,74605-050,Goiânia,Goiás,Brazil.
authors.forename: Marina C
authors.initials: MC
authors.lastname: Vinaud
authors.affiliation: Department of Microbiology,Immunology,Parasitology and Pathology,Tropical Pathology and Public Health Institute,Federal University of Goias,- Rua 235 S/N,Setor Universitário,74605-050,Goiânia,Goiás,Brazil.
authors.forename: Patricia R A N
authors.initials: PR
authors.lastname: Loyola
authors.affiliation: Department of Microbiology,Immunology,Parasitology and Pathology,Tropical Pathology and Public Health Institute,Federal University of Goias,- Rua 235 S/N,Setor Universitário,74605-050,Goiânia,Goiás,Brazil.
authors.forename: Ruy S
authors.initials: RS
authors.lastname: Lino
mesh_terms: D000818:Animals; D001921:Brain / Q000276:immunology / Q000469:parasitology; D016207:Cytokines / Q000032:analysis; D004195:Disease Models, Animal; D005260:Female; D007111:Immunity, Cellular; D051379:Mice; D008807:Mice, Inbred BALB C; D020019:Neurocysticercosis / Q000276:immunology* / Q000473:pathology*; D013154:Spleen / Q000166:cytology / Q000276:immunology
chemical_list: D016207:Cytokines
keywords: Neurocysticercosis; Taenia crassiceps; cytokines; immune profile; inflammation