title: Prevalence of Classic and Non-Classic Antiphospholipid Antibodies in Multiple Sclerosis.
abstract: BACKGROUND
  The association between antiphospholipid antibodies (aPL) and multiple sclerosis (MS) has been suggested previously, but prior studies provided contradicting findings.
  
  
  OBJECTIVE
  To characterize the expression profile of eight classic and non-classic aPL in patients diagnosed with MS.
  
  
  METHODS
  Using the BioPlex 2200 immunoassay, we measured the levels of serum immunoglobulin (Ig)M and IgG isotypes of three classic aPL and five non-classic aPL in 98 subjects with MS and 237 healthy controls.
  
  
  RESULTS
  Three non-classic aPL were significantly more prevalent among MS patients in comparison to the control group. These antibodies included IgM and IgG against phosphatidylserine-β2GPI (PS-B2), IgG prothrombin complex (PT-PT) and IgM prothrombin (PT). The positive results according to Bonferroni correction are PS-B2 IgG and PT-PT IgG. The remaining aPL profiles did not differ significantly between the two groups.
  
  
  CONCLUSIONS
  An association between certain non-classic aPL and MS has been established. The specific role of these autoantibodies in the pathogenesis of the condition remains uncertain.
authors.forename: Dana Ben-Ami
authors.initials: DB
authors.lastname: Shor
authors.forename: Guy A
authors.initials: GA
authors.lastname: Weiss
authors.forename: Ori
authors.initials: O
authors.lastname: Barzilai
authors.forename: Maya
authors.initials: M
authors.lastname: Ram
authors.forename: Juan-Manuel
authors.initials: JM
authors.lastname: Anaya
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
authors.forename: Yaniv
authors.initials: Y
authors.lastname: Sherer
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000276:immunology*; D015995:Prevalence
chemical_list: D017152:Antibodies, Antiphospholipid; D007074:Immunoglobulin G; D007075:Immunoglobulin M