title: Association Between Vitamin D Receptor rs731236 (Taq1) Polymorphism and Risk for Restless Legs Syndrome in the Spanish Caucasian Population.
abstract: Several recent works suggest a possible role of vitamin D deficiency in the etiology or restless legs syndrome (RLS). We analyzed the possible relationship of 2 common single nucleotide polymorphisms (SNPs) in the vitamin D3 receptor (VDR) gene with the risk for RLS.We studied the genotype and allelic variant frequencies of VDR rs2228570 and VDR rs731236 SNPs in 205 RLS patients and 445 healthy controls using a TaqMan essay.The frequencies of the rs731236AA genotype and the allelic variant rs731236A were significantly lower in RLS patients than in controls (P < 0.005 and < 0.01, respectively). Restless legs syndrome patients carrying the allelic variant rs731236G had an earlier age at onset, and those carrying the rs731236GG genotype had higher severity of RLS, although these data disappeared after multivariate analyses. None of the SNPs studied was related with the positivity of family history of RLS.These results suggest a modest, but significant association between VDR rs731236 SNP and the risk for RLS.
authors.affiliation: From the Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey (FJJ-J, HA-N, FN, MC, JFP-N, BP-D-LF, MA-S); Department of Pharmacology, University of Extremadura, Cáceres; Department of Medicine-Neurology, Hospital "Príncipe de Asturias", Universidad de Alcalá, Alcalá de Henares, Madrid (AR-S, LR, EG-A, FJJ-J, HA-N); Department of Pharmacology, Universidad de Extremadura, Cáceres (EG-M, JAGA); Department of Pharmacology, University of Extremadura, Badajoz (CM); Section of Neurology, Hospital Virgen del Puerto, Plasencia, Cáceres (MZ); Section of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan, Ciudad Real (LT-F, JM-P); Unit of Neurology, Clínica Recoletas, Zamora (TA-B); Section of Neurology, Hospital Universitario de Burgos, Burgos (EC); CIBERNED,Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III (SO-C, PP); Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, Universidad de Navarra, Pamplona (SO-C, PP); Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona (SO-C, PP); and Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain (PP).
authors.forename: Félix Javier
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
authors.forename: Elena
authors.initials: E
authors.lastname: García-Martín
authors.forename: Hortensia
authors.initials: H
authors.lastname: Alonso-Navarro
authors.forename: Carmen
authors.initials: C
authors.lastname: Martínez
authors.forename: Martín
authors.initials: M
authors.lastname: Zurdo
authors.forename: Laura
authors.initials: L
authors.lastname: Turpín-Fenoll
authors.forename: Jorge
authors.initials: J
authors.lastname: Millán-Pascual
authors.forename: Teresa
authors.initials: T
authors.lastname: Adeva-Bartolomé
authors.forename: Esther
authors.initials: E
authors.lastname: Cubo
authors.forename: Francisco
authors.initials: F
authors.lastname: Navacerrada
authors.forename: Ana
authors.initials: A
authors.lastname: Rojo-Sebastián
authors.forename: Lluisa
authors.initials: L
authors.lastname: Rubio
authors.forename: Sara
authors.initials: S
authors.lastname: Ortega-Cubero
authors.forename: Pau
authors.initials: P
authors.lastname: Pastor
authors.forename: Marisol
authors.initials: M
authors.lastname: Calleja
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Plaza-Nieto
authors.forename: Belén
authors.initials: B
authors.lastname: Pilo-De-La-Fuente
authors.forename: Margarita
authors.initials: M
authors.lastname: Arroyo-Solera
authors.forename: Esteban
authors.initials: E
authors.lastname: García-Albea
authors.forename: José A G
authors.initials: JAG
authors.lastname: Agúndez
mesh_terms: D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*; D012148:Restless Legs Syndrome / Q000235:genetics*; D012307:Risk Factors; D044465:White People
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human