title: Experimental study on the toxicity of povidone-iodine solution in brain tissues of rabbits.
abstract: OBJECTIVE
  To determine whether Povidone-iodine was toxic to brain tissues by rinsing the cerebral cortex of New Zealand rabbits with Povidone-iodine Solution of different concentrations.
  
  
  METHODS
  12 New Zealand rabbits were randomly divided into 4 groups (Group A, B, C and D, 3 rabbits each group). In each group, the left cerebral cortex of rabbits was rinsed with physiological saline after the craniotomy; in Group A and B, the right cerebral cortex of rabbits was also locally rinsed with Povidone-iodine Solution (0.01%), in Group C and D, the right cerebral cortex of rabbits was also locally rinsed with Povidone-iodine Solution (0.05%). In Group A and C, the rabbits were sacrificed at D3 after the operation, and the brain was taken out; and in Group B and D, the rabbits were sacrificed at D7 after the operation, and the brain was taken out. Under the optical and electron microscope, the change in micro-structure of brain tissues was observed in each group.
  
  
  RESULTS
  In each group, there was no epilepsy or paralysis during and after the operation. At the treatment side of physiological saline, there was no significant cell damage in the local brain tissues. At the treatment side of Povidone-iodine Solution, there was no cell apoptosis or degeneration in the local brain tissues.
  
  
  CONCLUSIONS
  The Povidone-iodine Solution (0.05% and 0.01%) was toxic to brain tissues, with a more obvious damage of brain tissues for the former concentration. The histological sign was more serious at D7 than that at D3.
authors.affiliation: College of Rehabilitation, Capital Medical University China.
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Beijing Boai Hospital, China Rehabilitation Research Center China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Beijing Boai Hospital, China Rehabilitation Research Center China ; Institute of Nerve Injury and Repair, Beijing Institute for Brain Disorders China.
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Gao
authors.affiliation: College of Rehabilitation, Capital Medical University China.
authors.forename: Kun
authors.initials: K
authors.lastname: Zhao
authors.affiliation: College of Rehabilitation, Capital Medical University China.
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Hou
authors.affiliation: Department of Neurosurgery, Beijing Boai Hospital, China Rehabilitation Research Center China ; Institute of Nerve Injury and Repair, Beijing Institute for Brain Disorders China.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
keywords: Povidone-iodine; brain tissues; rabbits; toxicity