title: Genetic association of the ApoB and ApoA1 gene polymorphisms with the risk for alcohol-induced osteonecrosis of femoral head.
abstract: Polymorphisms of apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1) gene and ApoB/ApoA1 Ratio were associated with lipid metabolism disorders in previous reports. The aim of this study assess whether variation of ApoB, ApoA1 gene are associated or not with alcohol-induced osteonecrosis of femoral head (ONFH). In a case-control study, we genotyped 4 single-nucleotide polymorphisms (SNPs) in ApoB and ApoA1 genes in 209 alcohol-induced ONFH patients and 300 healthy control subjects in Han Chinese population using χ(2) test and genetic model analysis. The analysis revealed that the frequencies of ApoB and ApoA1 genotypes were significantly different in alcohol-induced ONFH patients than in controls. We identified rs1042034, rs676210 and rs673548 in ApoB gene were associated with decreased risk of alcohol-induced ONFH using recessive model analysis (odds ratio [OR], 0.44; 95% confidence interval [CI], 0.19-0.99; P = 0.042), the OR, CI, P value of three SNPs were the same after adjusted for gender + age. We also identified rs632153 in ApoA1 gene was associated with increased risk of alcohol-induced ONFH using allele model (OR, 1.83; 95% CI, 1.16-2.88; P = 0.008) and log-additive model (adjusted OR, 1.77; 95% CI, 1.00-3.14; P = 0.046), analysis respectively. Haplotype analysis demonstrated no difference between ApoB and alcohol-induced ONFH. Polymorphisms of the ApoB and ApoA1 gene are associated with alcohol-induced ONFH in the Han Chinese population.
authors.affiliation: Inner Mongolia Medical University Hohhot 010010, Inner Mongolia, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Zhengzhou Traditional Chinese Medicine Traumatology Hospital Zhengzhou 450016, Henan, China.
authors.forename: Yuju
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Inner Mongolia Medical University Hohhot 010010, Inner Mongolia, China.
authors.forename: Yizhou
authors.initials: Y
authors.lastname: Li
authors.affiliation: Zhengzhou Traditional Chinese Medicine Traumatology Hospital Zhengzhou 450016, Henan, China.
authors.forename: Yongchang
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Zhengzhou Traditional Chinese Medicine Traumatology Hospital Zhengzhou 450016, Henan, China.
authors.forename: Quanjian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, Shaanxi, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, Shaanxi, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, Shaanxi, China ; School of Life Sciences, Northwest University Xi'an 710069, Shaanxi, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: Department of Orthopaedic Surgery, The Second Affiliated Hospital, Inner Mongolia Medical University Hohhot 010030, Inner Mongolia, China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Wang
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects* / Q000208:ethnology; D016632:Apolipoprotein A-I / Q000235:genetics*; D053299:Apolipoprotein B-100 / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D005271:Femur Head Necrosis / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D016015:Logistic Models; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: C505693:APOA1 protein, human; C569471:APOB protein, human; D016632:Apolipoprotein A-I; D053299:Apolipoprotein B-100; D005819:Genetic Markers
keywords: ApoA1; ApoB; alcohol; case-control study; gene polymorphisms; osteonecrosis of femoral head