title: Remodeling of Noncrosslinked Acellular Dermal Matrices in a Rabbit Model of Ventral Hernia Repair.
abstract: BACKGROUND
  Bioprostheses represent a significant advance in the abdominal wall reconstruction since they become degraded until their complete elimination in the recipient organism. This study examines remodeling in the host of three noncrosslinked porcine dermal collagen biomeshes: Strattice™ (St; LifeCell Corp.), XCM Biologic® Tissue Matrix (XCM; Synthes CMF) and Protexa® (Pr; Deco Med S.R.L.).
  
  
  METHODS
  Partial ventral hernia defects created in New Zealand White rabbits were repaired using the biomeshes that were placed in an inlay, preperitoneal position. At 14 and 90 days after implantation, explants were assessed in terms of their host tissue incorporation by morphological studies, collagen gene/protein expression (quantitative real-time PCR/immunofluorescence), macrophage response (immunohistochemistry) and biomechanical strength.
  
  
  RESULTS
  There were no cases of mortality or infection. Among our macroscopic findings, the mesh detachment detected in one third of the Pr implants at 90 days was of note. The host tissue response to all the biomeshes was similar at both time points, with a tendency observed for their encapsulation. There were no appreciable signs of mesh degradation. The extent of host tissue infiltration and collagenization was greater for St and Pr than for XCM. Macrophages were observed in zones of inflammation and tissue infiltration inside the mesh. XCM showed a greater macrophage response at 90 days (p < 0.05). Improved tensile strength was observed for St (p < 0.05) over Pr and unrepaired defects.
  
  
  CONCLUSIONS
  St showed the best behavior, featuring good collagenization and tensile strength while also inducing a minimal foreign body reaction.
authors.affiliation: Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcalx00E1;, Madrid, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Pascual
authors.forename: Sandra
authors.initials: S
authors.lastname: Sotomayor
authors.forename: Farah
authors.initials: F
authors.lastname: Adel
authors.forename: Bárbara
authors.initials: B
authors.lastname: Pérez-Köhler
authors.forename: Marta
authors.initials: M
authors.lastname: Rodríguez
authors.forename: Alberto
authors.initials: A
authors.lastname: Cifuentes
authors.forename: Juan M
authors.initials: JM
authors.lastname: Bellón
mesh_terms: D062088:Acellular Dermis; D000818:Animals; D001705:Bioprosthesis; D003094:Collagen / Q000235:genetics; D004195:Disease Models, Animal; D006555:Hernia, Ventral / Q000601:surgery*; D012333:RNA, Messenger / Q000032:analysis; D011817:Rabbits; D013526:Surgical Mesh; D013718:Tensile Strength
chemical_list: D012333:RNA, Messenger; D003094:Collagen