title: Validation of nuclear models in Geant4 using the dose distribution of a 177 MeV proton pencil beam.
abstract: A proton pencil beam is associated with a surrounding low-dose envelope, originating from nuclear interactions. It is important for treatment planning systems to accurately model this envelope when performing dose calculations for pencil beam scanning treatments, and Monte Carlo (MC) codes are commonly used for this purpose. This work aims to validate the nuclear models employed by the Geant4 MC code, by comparing the simulated absolute dose distribution to a recent experiment of a 177 MeV proton pencil beam stopping in water. Striking agreement is observed over five orders of magnitude, with both the shape and normalisation well modelled. The normalisations of two depth dose curves are lower than experiment, though this could be explained by an experimental positioning error. The Geant4 neutron production model is also verified in the distal region. The entrance dose is poorly modelled, suggesting an unaccounted upstream source of low-energy protons. Recommendations are given for a follow-up experiment which could resolve these issues.
authors.affiliation: Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Hall
authors.forename: Anastasia
authors.initials: A
authors.lastname: Makarova
authors.forename: Harald
authors.initials: H
authors.lastname: Paganetti
authors.forename: Bernard
authors.initials: B
authors.lastname: Gottschalk
mesh_terms: D000465:Algorithms; D008962:Models, Theoretical; D009010:Monte Carlo Method; D061766:Proton Therapy / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*