title: Synthesis of Novel Cellulose Carbamates Possessing Terminal Amino Groups and Their Bioactivity.
abstract: Cellulose phenyl carbonates are an excellent platform to synthesize a broad variety of soluble and functional cellulose carbamates. In this study, the synthesis of cellulose carbamates with terminal amino groups, namely ω-aminoethylcellulose- and ω-aminoethyl-p-aminobenzyl-cellulose carbamate, is discussed. The products are well soluble and their structures can be clearly described by NMR spectroscopy. The cellulose carbamates exhibit a bactericide and fungicide activity in vitro. The ω-aminoethylcellulose carbamate possesses a strong activity against Candida albicans and Staphylococcus aureus (IC50 of 0.02 mg mL(-1) and 0.05 mg mL(-1)). The antimicrobial activity and cytotoxicity can be improved by p-amino-benzylamine (ABA) as an additional substituent. The mixed cellulose carbamate exhibits a high biocompatibility (LC50 of 3.18 mg mL(-1)) and forms films on cotton and PES, which exhibit a strong activity against S. aureus and Klebsiella pneumoniae.
authors.affiliation: Center of Excellence for Polysaccharide Research, Institute of Organic, Chemistry and Macromolecular Chemistry, Friedrich Schiller University of Jena, Humboldtstraße 10, 07743, Jena, Germany.
authors.forename: Kristin
authors.initials: K
authors.lastname: Ganske
authors.affiliation: Department of Dermatology, University Hospital Center Jena, Erfurter Str. 35, 07743, Jena, Germany.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Wiegand
authors.affiliation: Department of Dermatology, University Hospital Center Jena, Erfurter Str. 35, 07743, Jena, Germany.
authors.forename: Uta-Christina
authors.initials: UC
authors.lastname: Hipler
authors.affiliation: Center of Excellence for Polysaccharide Research, Institute of Organic, Chemistry and Macromolecular Chemistry, Friedrich Schiller University of Jena, Humboldtstraße 10, 07743, Jena, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Heinze
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002176:Candida albicans / Q000502:physiology*; D002219:Carbamates / Q000737:chemistry / Q000494:pharmacology; D002482:Cellulose / Q000737:chemistry / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000502:physiology*; D013211:Staphylococcus aureus / Q000502:physiology*
chemical_list: D000890:Anti-Infective Agents; D002219:Carbamates; D002482:Cellulose