title: Early Life Stress Effects on Glucocorticoid-BDNF Interplay in the Hippocampus.
abstract: Early life stress (ELS) is implicated in the etiology of multiple psychiatric disorders. Important biological effects of ELS are manifested in stress-susceptible regions of the hippocampus and are partially mediated by long-term effects on glucocorticoid (GC) and/or neurotrophin signaling pathways. GC-signaling mediates the regulation of stress response to maintain homeostasis, while neurotrophin signaling plays a key role in neuronal outgrowth and is crucial for axonal guidance and synaptic integrity. The neurotrophin and GC-signaling pathways co-exist throughout the central nervous system (CNS), particularly in the hippocampus, which has high expression levels of glucocorticoid-receptors (GR) and mineralocorticoid-receptors (MR) as well as brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase receptor B (TrkB). This review addresses the effects of ELS paradigms on GC- and BDNF-dependent mechanisms and their crosstalk in the hippocampus, including potential implications for the pathogenesis of common stress-related disorders.
authors.affiliation: Traumatic Stress Studies Division and Laboratory of Molecular Neuropsychiatry, Department of Psychiatry, Icahn School of Medicine at Mount Sinai New York, NY, USA ; Mental Health Patient Care Center, James J. Peters Veterans Affairs Medical Center Bronx, NY, USA.
authors.forename: Nikolaos P
authors.initials: NP
authors.lastname: Daskalakis
authors.affiliation: Department of Medical Pharmacology, Leiden Academic Centre for Drug Research Leiden, Netherlands ; Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden University Leiden, Netherlands.
authors.forename: Edo Ronald
authors.initials: ER
authors.lastname: De Kloet
authors.affiliation: Traumatic Stress Studies Division and Laboratory of Molecular Neuropsychiatry, Department of Psychiatry, Icahn School of Medicine at Mount Sinai New York, NY, USA ; Mental Health Patient Care Center, James J. Peters Veterans Affairs Medical Center Bronx, NY, USA ; Department of Neuroscience, Icahn School of Medicine at Mount Sinai New York, NY, USA.
authors.forename: Rachel
authors.initials: R
authors.lastname: Yehuda
authors.affiliation: Department of Psychiatry, New York University School of Medicine New York, NY, USA.
authors.forename: Dolores
authors.initials: D
authors.lastname: Malaspina
authors.affiliation: Departments of Cell Biology, Physiology and Neuroscience, and Psychiatry, Skirball Institute of Biomolecular Medicine, New York University New York, NY, USA.
authors.forename: Thorsten M
authors.initials: TM
authors.lastname: Kranz
keywords: BDNF; HPA-axis; TrkB; early life stress; glucocorticoid; glucocorticoid receptor; hippocampus