title: H. pylori positivity and various pathological, endoscopic and clinical features correlated with each other.
abstract: OBJECTIVE
  To investigate the relationship between dyspepsia symptom scores and endoscopic appearances, and histopathological findings and helicobacter pylori positivity in patients having dyspepsia symptom.
  
  
  METHODS
  The study was conducted at the gastroenterology outpatient clinic of Adnan Menderes University, School of Medicine, Aydin, Turkey from April 2012 to July 2012 and comprised patients between 18-65 years of age who were admitted with dyspepsia. Glasgow dyspepsia severity scoring was done with questions posed orally to the patients. In histopathological evaluation of biopsy specimens according to Sydney criteria, chronic inflammation, activity, atrophy, intestinal metaplasia and helicobacter pylori parameters were used. Total number of eosinophils and number of mast cells were recorded.
  
  
  RESULTS
  Of the 60 patients with dyspepsia, 38(63.3%) were female and 22(36.7%) were male. The degree of activation and severity of inflammation increased significantly with increasing helicobacter pylori positivity(r=0.459'p<0.0001; r=0.475'p<0.0001). A significant relationship was found between inflammation, activation and the number of mast cells (p<0.05).There was no relationship between helicobacter pylori intensity and the eosinophil count (r=0.171; p=0.093). There was also a statistically significant correlation between severity of inflammation and activation and the number of eosinophils (r=0.313;p=0.002;r=0.245;p=0.016).
  
  
  CONCLUSIONS
  Mast cell density was seen to have a role in the inflammatory processes of helicobacter pylori infection.
authors.affiliation: Department of Gastroenterology, Adnan Menderes University, School of Medicine, Aydin, Turkey.
authors.forename: Adil
authors.initials: A
authors.lastname: Coskun
authors.affiliation: Department of Gastroenterology, Adnan Menderes University, School of Medicine, Aydin, Turkey.
authors.forename: Vahit
authors.initials: V
authors.lastname: Yukselen
authors.affiliation: Department of Pathology, Adnan Menderes University, School of Medicine, Aydin, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Meteoglu
authors.affiliation: Department of Public Health, Adnan Menderes University, School of Medicine, Aydin, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Ergin
authors.affiliation: Deparment of Hematology, Adnan Menderes University, School of Medicine, Aydin, Turkey.
authors.forename: Gurhan
authors.initials: G
authors.lastname: Kadikoylu
authors.affiliation: Department of Gastroenterology, Adnan Menderes University, School of Medicine, Aydin, Turkey.
authors.forename: Mehmet Hadi
authors.initials: MH
authors.lastname: Yasa
authors.affiliation: Department of Gastroenterology, Adnan Menderes University, School of Medicine, Aydin, Turkey.
authors.forename: Ali Onder
authors.initials: AO
authors.lastname: Karaoglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D004415:Dyspepsia / Q000382:microbiology* / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D014421:Turkey; D055815:Young Adult
keywords: Helicobacter pylori, Dyspepsia, Mast cells, Eosinophils.