title: On-Going Frontal Alpha Rhythms Are Dominant in Passive State and Desynchronize in Active State in Adult Gray Mouse Lemurs.
abstract: The gray mouse lemur (Microcebus murinus) is considered a useful primate model for translational research. In the framework of IMI PharmaCog project (Grant Agreement n°115009, www.pharmacog.org), we tested the hypothesis that spectral electroencephalographic (EEG) markers of motor and locomotor activity in gray mouse lemurs reflect typical movement-related desynchronization of alpha rhythms (about 8-12 Hz) in humans. To this aim, EEG (bipolar electrodes in frontal cortex) and electromyographic (EMG; bipolar electrodes sutured in neck muscles) data were recorded in 13 male adult (about 3 years) lemurs. Artifact-free EEG segments during active state (gross movements, exploratory movements or locomotor activity) and awake passive state (no sleep) were selected on the basis of instrumental measures of animal behavior, and were used as an input for EEG power density analysis. Results showed a clear peak of EEG power density at alpha range (7-9 Hz) during passive state. During active state, there was a reduction in alpha power density (8-12 Hz) and an increase of power density at slow frequencies (1-4 Hz). Relative EMG activity was related to EEG power density at 2-4 Hz (positive correlation) and at 8-12 Hz (negative correlation). These results suggest for the first time that the primate gray mouse lemurs and humans may share basic neurophysiologic mechanisms of synchronization of frontal alpha rhythms in awake passive state and their desynchronization during motor and locomotor activity. These EEG markers may be an ideal experimental model for translational basic (motor science) and applied (pharmacological and non-pharmacological interventions) research in Neurophysiology.
authors.affiliation: IRCCS San Raffaele Pisana, Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Infarinato
authors.affiliation: UMR 7179 Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, Brunoy, France.
authors.forename: Anisur
authors.initials: A
authors.lastname: Rahman
authors.affiliation: IRCCS SDN, Naples, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Del Percio
authors.affiliation: UCB Pharma s.a., Neuroscience Therapeutic Area, Braine l'Alleud, Belgium.
authors.forename: Yves
authors.initials: Y
authors.lastname: Lamberty
authors.affiliation: L'Université Lille 2 Droit et Santé, Lille, France.
authors.forename: Regis
authors.initials: R
authors.lastname: Bordet
authors.affiliation: Neurosciences Therapeutic Area Unit, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, United Kingdom.
authors.forename: Jill C
authors.initials: JC
authors.lastname: Richardson
authors.affiliation: Department of Neurodegeneration, Mario Negri Institute, Milan, Italy.
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Forloni
authors.affiliation: Janssen Research & Development, Turnhoutsewe, Beerse, Belgium.
authors.forename: Wilhelmus
authors.initials: W
authors.lastname: Drinkenburg
authors.affiliation: Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Lopez
authors.affiliation: UMR 7179 Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, Brunoy, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Aujard
authors.affiliation: IRCCS San Raffaele Pisana, Rome, Italy.|Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Babiloni
authors.affiliation: UMR 7179 Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, Brunoy, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Pifferi
mesh_terms: D000513:Alpha Rhythm; D000818:Animals; D016565:Cheirogaleidae; D003344:Cortical Synchronization; D019054:Evoked Potentials, Motor; D005625:Frontal Lobe / Q000254:growth & development / Q000502:physiology*; D009043:Motor Activity