title: Langerhans cells (CD1a and CD207), dermal dendrocytes (FXIIIa) and plasmacytoid dendritic cells (CD123) in skin lesions of leprosy patients.
abstract: The clinical course of infection with Mycobacterium leprae varies widely and depends on the pattern of the host immune response. Dendritic cells play an important role in the activation of the innate and adaptive immune system and seem to be essential for the development of the disease. To analyze the presence of epidermal dendritic cells (CD1a and CD207), plasmacytoid dendritic cells (CD123) and dermal dendrocytes (factor XIIIa) in lesion fragments of leprosy patients, skin samples from 30 patients were studied. These samples were submitted to immunohistochemistry against CD1a, CD207, FXIIIa, and CD123. The results showed a larger number of Langerhans cells, detected with the CD1a or CD207 marker, dermal dendrocytes and plasmacytoid dendritic cells in patients with the tuberculoid form. A positive correlation was observed between the Langerhans cell markers CD1a and CD207 in both the tuberculoid and lepromatous forms, and between Langerhans cells and dermal dendrocytes in samples with the tuberculoid form. The present results indicate the existence of a larger number of dendritic cells in patients at the resistant pole of the disease (tuberculoid) and suggest that the different dendritic cells studied play a role, favoring an efficient immune response against infection with M. leprae.
authors.affiliation: Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil.
authors.forename: Kelly Emi
authors.initials: KE
authors.lastname: Hirai
authors.affiliation: Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil.
authors.forename: Tinara Leila de Sousa
authors.initials: TL
authors.lastname: Aarão
authors.affiliation: Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil.
authors.forename: Luciana Mota
authors.initials: LM
authors.lastname: Silva
authors.affiliation: Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Para, Brazil.
authors.forename: Jorge Rodrigues
authors.initials: JR
authors.lastname: de Sousa
authors.affiliation: Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil.
authors.forename: Juarez
authors.initials: J
authors.lastname: de Souza
authors.affiliation: Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil.
authors.forename: Leonidas Braga
authors.initials: LB
authors.lastname: Dias
authors.affiliation: Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Para, Brazil.
authors.forename: Francisca Regina Oliveira
authors.initials: FR
authors.lastname: Carneiro
authors.affiliation: Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Para, Brazil.
authors.forename: Hellen Thais
authors.initials: HT
authors.lastname: Fuzii
authors.affiliation: Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil; Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Para, Brazil. Electronic address: juarez@pesquisador.cnpq.br.
authors.forename: Juarez Antonio Simões
authors.initials: JA
authors.lastname: Quaresma
mesh_terms: D015703:Antigens, CD / Q000276:immunology*; D018949:Antigens, CD1 / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D020405:Dermis / Q000166:cytology / Q000276:immunology; D026122:Factor XIIIa / Q000276:immunology*; D006801:Humans; D053650:Interleukin-3 Receptor alpha Subunit / Q000276:immunology*; D007801:Langerhans Cells / Q000276:immunology*; D037181:Lectins, C-Type / Q000276:immunology*; D007918:Leprosy / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D037241:Mannose-Binding Lectins / Q000276:immunology*; D009166:Mycobacterium leprae / Q000502:physiology; D012867:Skin / Q000276:immunology* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D018949:Antigens, CD1; C419393:CD1a antigen; C121916:CD207 protein, human; D053650:Interleukin-3 Receptor alpha Subunit; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins; D026122:Factor XIIIa
keywords: Dendritic cells; Immunology; Immunopathology; Mycobacterium leprae