title: Elevated sL1-CAM levels in BALF and serum of IPF patients.
abstract: OBJECTIVE
  IPF is a form of interstitial pneumonia of unknown origin that has a poor prognosis for which current treatments are limited. Recent studies have shown that EMT plays a role in IPF and tumour metastasis. L1-CAM has also been linked to EMT during tumour development and tumour metastasis. Our aim was to determine prospectively the level of L1-CAM in IPF patients.
  
  
  METHODS
  Forty consecutive Chinese patients (with IPF, 16; LC, 12; and CC, 12), but no apparent lung or other organ's diseases were enrolled. Soluble L1-CAM (sL1-CAM), TGF-β1, PDGF, γ-INF levels in BALF and serum sL1-CAM were measured using ELISA.
  
  
  RESULTS
  BALF sL1-CAM levels of IPF, LC and CC patients were 10.87 ± 0.88 ng/mL, 6.34 ± 0.67 ng/mL and 5.43 ± 0.65 ng/mL, respectively. BALF sL1-CAM concentration of IPF patients was significantly higher than that in LC and in CC patients. Besides, serum sL1-CAM levels in patients with IPF, LC and CC were 9.60 ± 1.41 ng/mL, 9.82 ± 0.72 ng/mL and 5.41 ± 1.07 ng/mL, respectively. The serum sL1-CAM levels in patients with IPF and LC were significantly higher than those in patients with CC (P < 0.001, respectively).
  
  
  CONCLUSIONS
  The concentrations of sL1-CAM both in BALF and in serum of patients with IPF are markedly increased compared with controls. This indicates that L1-CAM might be involved in the pathogenesis of IPF as well as that of LC.
authors.affiliation: Department of Respiratory Diseases, Nanjing Drum Tower Hospital affiliated to Medical School of Nanjing University, Nanjing, China.
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Oncology and Hematology, China-Japan Union Hospital Affiliated to Jilin University, Changchun, China.
authors.forename: Lintao
authors.initials: L
authors.lastname: Bi
authors.affiliation: Department of Respiratory Diseases, Nanjing Drum Tower Hospital affiliated to Medical School of Nanjing University, Nanjing, China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Department of Radiology, Nanjing Drum Tower Hospital affiliated to Medical School of Nanjing University, Nanjing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Respiratory Diseases, Nanjing Drum Tower Hospital affiliated to Medical School of Nanjing University, Nanjing, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Ding
authors.affiliation: Department of Respiratory Diseases, Nanjing Drum Tower Hospital affiliated to Medical School of Nanjing University, Nanjing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhuang
authors.affiliation: Department of Respiratory Diseases, Nanjing Drum Tower Hospital affiliated to Medical School of Nanjing University, Nanjing, China.
authors.forename: Yaqiong
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Respiratory Diseases, Nanjing Drum Tower Hospital affiliated to Medical School of Nanjing University, Nanjing, China.
authors.forename: Hourong
authors.initials: H
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology*; D002681:China; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000276:immunology / Q000473:pathology; D007371:Interferon-gamma / Q000276:immunology; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D039842:Neural Cell Adhesion Molecule L1 / Q000097:blood / Q000276:immunology; D010982:Platelet-Derived Growth Factor / Q000276:immunology; D013223:Statistics as Topic; D053773:Transforming Growth Factor beta1 / Q000276:immunology
chemical_list: D039842:Neural Cell Adhesion Molecule L1; D010982:Platelet-Derived Growth Factor; D053773:Transforming Growth Factor beta1; D007371:Interferon-gamma
keywords: L1 cell adhesion molecule; idiopathic pulmonary fibrosis; lung cancer