title: Antioxidant Effect of Polyoxidonium and Metaprot during Bronchopulmonary Inflammation in Rats.
abstract: The antioxidant effects of individual or combined application of polyoxidonium and metaprot were examined in rats with acute bronchopulmonary inflammation. By degree of antioxidant potency, polyoxidonium was inferior to metaprot, but their combined application produced more potent antioxidant effect. Polyoxidonium and metaprot in low concentrations increased and in high concentrations suppressed spontaneous biochemiluminescence in the model system of alveolar macrophages.
authors.affiliation: Department of Pharmacology, Military Medical Academy, Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Zarubina
authors.affiliation: Department of Pharmacology, Military Medical Academy, Ministry of Defense of the Russian Federation, St. Petersburg, Russia. pdshabanov@mail.ru.
authors.forename: P D
authors.initials: PD
authors.lastname: Shabanov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D008171:Lung Diseases / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D010879:Piperazines / Q000627:therapeutic use*; D011108:Polymers / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D001562:Benzimidazoles; D010879:Piperazines; D011108:Polymers; C049825:bemethyl; C540909:azoximer bromide
keywords: bronchopulmonary inflammation; lipid peroxidation; metaprot; polyoxidonium