title: Relationship between adiponectin receptor 1 gene polymorphisms and ischemic stroke.
abstract: OBJECTIVE
  Previous study suggested adiponectin receptor 2 (ADIPOR2) genetic polymorphisms were associated with the risk of ischemic stroke. However, the relation between adiponectin receptor 1 (ADIPOR1) gene polymorphism and stroke remains unclear.
  
  
  METHODS
  In the present study, we utilized the polymerase chain reaction-sequencing method to detect rs2275737 and s1342387 genotypes of ADIPOR1 gene in 300 cases of ischemic stroke patients and 300 age- and sex- matched healthy controls.
  
  
  RESULTS
  For rs2275737, we found A allele carriers have increased risk to ischemic stroke (OR=2.570, 95% CI: 1.999-3.305); also, we found rs1342387 A allele was associated with the risk for stroke (OR=1.351, 95% CI: 1.074-1.699). After adjusted for confounders such as hypertension, diabetes, and smoking, we found the association remains significant.
  
  
  CONCLUSIONS
  ADIPOR1 genetic polymorphism may increase the risk of ischemic stroke.
authors.affiliation: Department of Internal Neurology, Tianjin 4th Central Hospital Tianjin 300140, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Han
authors.affiliation: Department of Medical Affairs, Affiliated Hospital of Changchun University of Traditional Chinese Medicine Changchun 130021, China.
authors.forename: Zunhua
authors.initials: Z
authors.lastname: Shu
authors.affiliation: Department of Internal Neurology, Tianjin 4th Central Hospital Tianjin 300140, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Liang
authors.affiliation: College of Humanities, Kunming Medical University China.
authors.forename: Rui
authors.initials: R
authors.lastname: Mi
authors.affiliation: Department of Neurosurgery , Kunming Children's Hospital Kunming 650030, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.affiliation: Medical Faculty of Kunming University of Science and Technology Kunming 650000, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
keywords: Ischemic stroke; adiponectin receptor 1 gene; single nucleotide polymorphisms