title: [Synthesis and Pharmacological Activity of N-Hetaryl-3(5)-Nitropyridines].
abstract: Reacting a number chlorosubstituted 3(5)-nitropyridine with some diazoles or 3-chloropyridazin-6-one synthesized previously undescribed various 2-, 4- or 6-substituted hetaryl-3(5)-nitropyridines. Furthermore, pyrazolyl-3-nitropyridine prepared by cyclizing hydrazinopyridine resulting from the nucleophilic substitution of chlorine in chlorosubstituted 3-nitropyridine by hydrazine. It has been shown that these compounds have moderate antibacterial activity against some pathogenic Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Escherichia coli), as well as a strong effect on protistocidal action form Colpoda steinii, surpassing clinically used reference drugs.
authors.forename: A I
authors.initials: AI
authors.lastname: Klimenko
authors.forename: L N
authors.initials: LN
authors.lastname: Divaeva
authors.forename: A A
authors.initials: AA
authors.lastname: Zubenko
authors.forename: A S
authors.initials: AS
authors.lastname: Morkovnik
authors.forename: L N
authors.initials: LN
authors.lastname: Fetisov
authors.forename: A N
authors.initials: AN
authors.lastname: Bodryakov
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000254:growth & development*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000254:growth & development*
chemical_list: D000890:Anti-Infective Agents; D011725:Pyridines