title: Antioxidant Effect of Erythropoietin during Experimental Chronic Renal Failure.
abstract: The effects of erythropoietin (Epokrin, 900 U/kg) on the parameters of free radical oxidation in the plasma and lymphocytes of peripheral blood were studied in rats with chronic renal failure. We observed accumulation of primary (diene conjugates) and secondary (ketodienes, and conjugated trienes) LPO products in the heptane and isopropanol fractions of blood plasma and a decrease in superoxide dismutase and catalase activities in blood plasma. In lymphocytes, the concentration of primary, secondary and end-products (Schiff bases) of LPO increased in the isopropanol fraction of lipid extract. Treatment with erythropoietin was followed by a decrease in the level of primary and end-products of LPO in the isopropanol fraction of lipid extract of the plasma and lymphocytes and an increase in of superoxide dismutase and catalase activities in the plasma. The content of primary LPO products in the isopropanol fraction of the plasma progressively decreased with increasing superoxide dismutase and catalase activities in the plasma.
authors.affiliation: South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia. mvo2003@list.ru.
authors.forename: M V
authors.initials: MV
authors.lastname: Osikov
authors.affiliation: South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia.
authors.forename: L F
authors.initials: LF
authors.lastname: Telesheva
authors.affiliation: South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Ageev
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use*; D004921:Erythropoietin / Q000494:pharmacology* / Q000627:therapeutic use*; D005609:Free Radicals / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D004921:Erythropoietin; D013482:Superoxide Dismutase
keywords: LPO products; catalase; erythropoietin; superoxide dismutase: chronic renal Failure