title: Outcomes of hepatitis B surface antigenaemia in patients with incident end-stage renal disease.
abstract: OBJECTIVE
  Hepatitis B virus (HBV) infection is an important risk factor for morbidity and mortality in the general population. However, limited data are available on the progression of HBV infection in patients with end-stage renal disease (ESRD), and available data are controversial. Therefore, we investigated the association between hepatitis B surface antigen (HBsAg) seropositivity and mortality in patients with incident ESRD.
  
  
  METHODS
  All adult patients (≥18 years of age) starting dialysis for ESRD from January 2000 to December 2011 were included. A total of 1090 patients with ESRD were analyzed. HBsAg-positive patients were paired 1:6 with HBsAg-negative patients using propensity score matching.
  
  
  RESULTS
  Eighty one (7.4%) patients were HBsAg positive. No differences in the survival rates of the HBsAg-positive and HBsAg-negative patients with ESRD were detected in either the entire cohort or the propensity score matched cohort. No differences in survival were detected between the groups of HBsAg-positive patients based on the hepatitis B envelope antigen, hepatitis B envelope antibody, HBV DNA status, or use of antiviral agents. No difference in mortality was found between the haemodialysis (HD) and peritoneal dialysis (PD) subgroups among HBsAg-positive patients.
  
  
  CONCLUSIONS
  Our results suggest that hepatitis B surface antigenaemia is not related to increased mortality in patients with incident ESRD. Survival of HBsAg-positive patients undergoing PD was comparable to that of patients undergoing HD.
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center.
authors.forename: Ae Jin
authors.initials: AJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gachon University School of Medicine, Incheon, Korea.
authors.forename: Jin Hwan
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Preventive Medicine, Gachon University School of Medicine, Incheon, Korea.
authors.forename: Kwang-Pil
authors.initials: KP
authors.lastname: Ko
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center.
authors.forename: Eul Sik
authors.initials: ES
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center.
authors.forename: Byoung Ho
authors.initials: BH
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center.|Department of Internal Medicine, Gachon University School of Medicine, Incheon, Korea.
authors.forename: Han
authors.initials: H
authors.lastname: Ro
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center.|Department of Internal Medicine, Gachon University School of Medicine, Incheon, Korea.
authors.forename: Ji Yong
authors.initials: JY
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center.|Department of Internal Medicine, Gachon University School of Medicine, Incheon, Korea.
authors.forename: Hyun Hee
authors.initials: HH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center.|Department of Internal Medicine, Gachon University School of Medicine, Incheon, Korea.
authors.forename: Wookyung
authors.initials: W
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center. jhchang@gilhospital.com.|Department of Internal Medicine, Gachon University School of Medicine, Incheon, Korea. jhchang@gilhospital.com.
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Chang
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D015897:Comorbidity; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009026:Mortality; D057216:Propensity Score; D006435:Renal Dialysis / Q000379:methods / Q000706:statistics & numerical data*; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D013223:Statistics as Topic
chemical_list: D000998:Antiviral Agents; D006514:Hepatitis B Surface Antigens
keywords: end-stage renal disease; haemodialysis; hepatitis B virus; mortality; peritoneal dialysis