title: orthoFind Facilitates the Discovery of Homologous and Orthologous Proteins.
abstract: Finding homologous and orthologous protein sequences is often the first step in evolutionary studies, annotation projects, and experiments of functional complementation. Despite all currently available computational tools, there is a requirement for easy-to-use tools that provide functional information. Here, a new web application called orthoFind is presented, which allows a quick search for homologous and orthologous proteins given one or more query sequences, allowing a recurrent and exhaustive search against reference proteomes, and being able to include user databases. It addresses the protein multidomain problem, searching for homologs with the same domain architecture, and gives a simple functional analysis of the results to help in the annotation process. orthoFind is easy to use and has been proven to provide accurate results with different datasets. Availability: http://www.bioinfocabd.upo.es/orthofind/.
authors.affiliation: Centro Andaluz de Biología del Desarrollo (CABD), CSIC-UPO-JA. Facultad de Ciencias Experimentales (Área de Genética), Universidad Pablo de Olavide, ES-41013, Sevilla, Spain.|Institute of Molecular Biology, Mainz, Germany.
authors.forename: Pablo
authors.initials: P
authors.lastname: Mier
authors.affiliation: Faculty of Biology, Johannes Gutenberg University Mainz, Mainz, Germany.|Institute of Molecular Biology, Mainz, Germany.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Andrade-Navarro
authors.affiliation: Centro Andaluz de Biología del Desarrollo (CABD), CSIC-UPO-JA. Facultad de Ciencias Experimentales (Área de Genética), Universidad Pablo de Olavide, ES-41013, Sevilla, Spain.
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Pérez-Pulido
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030541:Databases, Genetic; D006801:Humans; D020407:Internet; D011506:Proteins / Q000235:genetics*; D016415:Sequence Alignment / Q000379:methods; D017386:Sequence Homology, Amino Acid; D012984:Software
chemical_list: D011506:Proteins