title: The History of Incidentally Discovered Penetrating Aortic Ulcers of the Abdominal Aorta.
abstract: BACKGROUND
  The management of incidentally discovered penetrating ulcers of the abdominal aorta (PUAA) is not well described.
  
  
  METHODS
  A search of computed tomography (CT) angiography imaging reports for the words "penetrating ulcer" was performed from October 2010 to August 2011. Patients with a PUAA were identified, and their clinical course was followed through December 2014 (n = 53). No specific intervention for the ulcers was sought unless additional aortic pathology necessitated intervention. Prospective and retrospective review of imaging was performed by dedicated vascular radiologists. Aortic diameters and ulcer dimensions were measured for patients with repeat imaging. Mann-Whitney U, Fisher's exact, and Pearson correlation coefficient tests were performed for statistical analysis.
  
  
  RESULTS
  The calculated incidence of PUAA for patients undergoing CT imaging was 0.48%. Age at diagnosis was 71.6 ± 10.5 years in a population that included 35 (66.0%) males. Repeat imaging was performed for 29 (54.7%) patients. Median clinical and imaging follow-up was 36 (1-127) months and 34 (1-89) months. A history of hypertension (92.5%), hyperlipidemia (77.4%), and tobacco use (81.8%) was common. Twenty-seven (50.9%) had concomitant aneurysms not necessarily associated with PUAA. No aortic aneurysm or PUAA rupture occurred, but the population was sick with 19 patients (35.8%) deceased at the end of the study. Median aortic diameter growth rate through the PUAA was 0.5 (0-11.4) mm/year. No difference in mortality or aortic pathology was detected in patients with aortic growth rates >1 mm/year compared with <1 mm/year (P = 0.21 and P = 0.71, respectively).
  
  
  CONCLUSIONS
  Patients with PUAA in general are elderly with multiple comorbidities. A large percentage of patients have concurrent, separate, aortic pathology, most frequently aortic aneurysms. Small changes in the appearance of the PUAA were frequent but did not equate with abdominal aortic catastrophe. Long-term mortality for this population was high, but the ulcer growth during follow-up did not suggest PUAA treatment would improve survival.
authors.affiliation: Division of Vascular Surgery, University of Maryland Medical Center, Baltimore, MD. Electronic address: tanya.flohr@gmail.com.
authors.forename: Tanya R
authors.initials: TR
authors.lastname: Flohr
authors.affiliation: Department of Radiology, University of Virginia Health System, Charlottesville, VA.
authors.forename: Klaus D
authors.initials: KD
authors.lastname: Hagspiel
authors.affiliation: Division of Vascular Surgery, University of Cincinnati, Cincinnati, OH.
authors.forename: Amit
authors.initials: A
authors.lastname: Jain
authors.affiliation: Division of Vascular Surgery, University of Virginia Health System, Charlottesville, VA.
authors.forename: Margaret C
authors.initials: MC
authors.lastname: Tracci
authors.affiliation: Division of Vascular Surgery, University of Virginia Health System, Charlottesville, VA.
authors.forename: John A
authors.initials: JA
authors.lastname: Kern
authors.affiliation: Division of Vascular Surgery, University of Virginia Health System, Charlottesville, VA.
authors.forename: Irving L
authors.initials: IL
authors.lastname: Kron
authors.affiliation: Division of Vascular Surgery, University of Virginia Health System, Charlottesville, VA.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Cherry
authors.affiliation: Division of Vascular Surgery, University of Virginia Health System, Charlottesville, VA.
authors.forename: Gilbert R
authors.initials: GR
authors.lastname: Upchurch
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging; D001018:Aortic Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000628:therapy; D001027:Aortography / Q000379:methods; D015897:Comorbidity; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D014456:Ulcer / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000628:therapy; D014768:Virginia / Q000453:epidemiology