title: Radiosurgery Using Tomotherapy for Patients with Brain Oligo-metastasis: A Retrospective Analysis on Feasibility and Tolerance.
abstract: OBJECTIVE
  Aim of the study was to evaluate feasibility and toxicities of exclusive radiosurgery using tomotherapy in patients with brain oligo-metastases.
  
  
  METHODS
  Between 2008 and 2013 68 patients underwent stereotactic radiosurgery (SRS). Mean patient age was 63 years. Brain was the only site involved in 32 patients, while 36 had extracranial disease. Pre-SRS MRI 56 patients had sovratentorial lesions, 10 subtentorial and 2 patients had both. Fifty-two patients had 1 brain lesion, 11 had 2, and 5 patients had three. All patients underwent SRS using Tomotherapy. The median delivered dose was 18 Gy.
  
  
  RESULTS
  After a mean follow-up of 13 months, 14 patients were alive, while 54 patients had died. Two patients had complete response, 32 had partial response, 21 stable disease and 13 disease progression. Overall response rate was 80.9%. One- and two-year overall survival were 41,2% and 24,7%, while local control 61.5% and 37.7%. Toxicity was acceptable.
  
  
  CONCLUSIONS
  SRS using tomotherapy has been proven feasible as non-invasive exclusive treatment for oligometastatic patients with good prognostic score.
authors.affiliation: Radiation Oncology Department, Azienda Ospedaliero Universitaria "Policlinico" di Modena, Modena, Italy brunialessio@virgilio.it.
authors.forename: Alessio
authors.initials: A
authors.lastname: Bruni
authors.affiliation: Radiation Oncology Department, Azienda Ospedaliero Universitaria "Policlinico" di Modena, Modena, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Gaito
authors.affiliation: Medical Physics Department, Azienda Ospedaliero Universitaria "Policlinico" di Modena, Modena, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Ciarmatori
authors.affiliation: Radiation Oncology Department, Azienda Ospedaliero Universitaria "Policlinico" di Modena, Modena, Italy.
authors.forename: Biancaluisa
authors.initials: B
authors.lastname: Lanfranchi
authors.affiliation: Radiation Oncology Department, Azienda Ospedaliero Universitaria "Policlinico" di Modena, Modena, Italy.
authors.forename: Ercole
authors.initials: E
authors.lastname: Mazzeo
authors.affiliation: Medical Physics Department, Azienda Ospedaliero Universitaria "Policlinico" di Modena, Modena, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Maffei
authors.affiliation: Radiation Oncology Department, Azienda Ospedaliero Universitaria "Policlinico" di Modena, Modena, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Giacobazzi
authors.affiliation: Radiation Oncology Department, Azienda Ospedaliero Universitaria "Policlinico" di Modena, Modena, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Turco
authors.affiliation: Medical Physics Department, Azienda Ospedaliero Universitaria "Policlinico" di Modena, Modena, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Guidi
authors.affiliation: Radiation Oncology Department, Azienda Ospedaliero Universitaria "Policlinico" di Modena, Modena, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Bertoni
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000532:radiotherapy*; D018450:Disease Progression; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D016634:Radiosurgery / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D012189:Retrospective Studies
keywords: Stereotactic radiosurgery; brain metastasis; tomotherapy