title: Pharmacologic Activities of 3'-Hydroxypterostilbene: Cytotoxic, Anti-Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase and Sirtuin 1 Inhibitory Activity.
abstract: OBJECTIVE
  Delineate the selected pharmacodynamics of a naturally occurring stilbene 3'-Hydroxypterostilbene.
  
  
  OBJECTIVE
  Characterize for the first time the pharmacodynamics bioactivity in several in-vitro assays with relevant roles in heart disease, inflammation, cancer, and diabetes etiology and pathophysiology.
  
  
  METHODS
  3'-Hydroxypterostilbene was studied in in-vitro assays to identify possible bioactivity.
  
  
  RESULTS
  3'-Hydroxypterostilbene demonstrated anti-oxidant, anti-inflammatory, cytotoxic, anti-adipogenic, histone deacetylase, and sirtuin-1 inhibitory activity.
  
  
  CONCLUSIONS
  The importance of understanding individual stilbene pharmacologic activities were delineated. Small changes in chemical structure of stilbene compounds result in significant pharmacodynamic differences. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.
authors.affiliation: Department of Pharmaceutical Sciences, Ben and Maytee Fisch College of Pharmacy, The University of Texas at Tyler, Tyler, Texas. Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, Washington.
authors.forename: Jody K
authors.initials: JK
authors.lastname: Takemoto
authors.forename: Connie M
authors.initials: CM
authors.lastname: Remsberg
authors.forename: Neal M
authors.initials: NM
authors.lastname: Davies
mesh_terms: D041721:3T3-L1 Cells; D050156:Adipogenesis / Q000187:drug effects; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D056564:Sirtuin 1 / Q000037:antagonists & inhibitors; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: C505072:3'-hydroxypterostilbene; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D013267:Stilbenes; D056564:Sirtuin 1; D006655:Histone Deacetylases