title: Pediatric gliomas as neurodevelopmental disorders.
abstract: Brain tumors represent the most common solid tumor of childhood, with gliomas comprising the largest fraction of these cancers. Several features distinguish them from their adult counterparts, including their natural history, causative genetic mutations, and brain locations. These unique properties suggest that the cellular and molecular etiologies that underlie their development and maintenance might be different from those that govern adult gliomagenesis and growth. In this review, we discuss the genetic basis for pediatric low-grade and high-grade glioma in the context of developmental neurobiology, and highlight the differences between histologically-similar tumors arising in children and adults.
authors.affiliation: Department of Developmental Neurobiology, St. Jude's Children's Research Hospital, Memphis, Tennessee.
authors.forename: Suzanne J
authors.initials: SJ
authors.lastname: Baker
authors.affiliation: Department of Pathology, St. Jude's Children's Research Hospital, Memphis, Tennessee.
authors.forename: David W
authors.initials: DW
authors.lastname: Ellison
authors.affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, Missouri.
authors.forename: David H
authors.initials: DH
authors.lastname: Gutmann
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D009154:Mutation / Q000235:genetics*; D065886:Neurodevelopmental Disorders / Q000235:genetics*
keywords: DIPG; diffuse astrocytoma; glioblastoma; pediatric glioma; pilocytic astrocytoma