title: Ligand-Promoted Borylation of C(sp(3))-H Bonds with Palladium(II) Catalysts.
abstract: A quinoline-based ligand effectively promotes the palladium-catalyzed borylation of C(sp(3))-H bonds. Primary β-C(sp(3))-H bonds in carboxylic acid derivatives as well as secondary C(sp(3))-H bonds in a variety of carbocyclic rings, including cyclopropanes, cyclobutanes, cyclopentanes, cyclohexanes, and cycloheptanes, can thus be borylated. This directed borylation method complements existing iridium(I)- and rhodium(I)-catalyzed C-H borylation reactions in terms of scope and operational conditions.
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
authors.forename: Jian
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
authors.forename: Heng
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Takise
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
authors.forename: Ru-Yi
authors.initials: RY
authors.lastname: Zhu
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
authors.forename: Hui-Xiong
authors.initials: HX
authors.lastname: Dai
authors.affiliation: Discovery Chemistry, Bristol-Myers Squibb Company, Route 206 and Provinceline Road, Princeton, NJ 08543 (USA).
authors.forename: T G Murali
authors.initials: TG
authors.lastname: Dhar
authors.affiliation: Discovery Chemistry, Bristol-Myers Squibb Company, 311 Pennington Rocky Hill Road, Pennington, NJ 08534 (USA).
authors.forename: Jun
authors.initials: J
authors.lastname: Shi
authors.affiliation: Discovery Chemistry, Bristol-Myers Squibb Company, 311 Pennington Rocky Hill Road, Pennington, NJ 08534 (USA).
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Discovery Chemistry, Bristol-Myers Squibb Company, 311 Pennington Rocky Hill Road, Pennington, NJ 08534 (USA).
authors.forename: Peter T W
authors.initials: PT
authors.lastname: Cheng
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA). yu200@scripps.edu.
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
mesh_terms: D001896:Boron Compounds / Q000737:chemistry*; D002384:Catalysis; D006860:Hydrogen Bonding; D008024:Ligands; D010165:Palladium / Q000737:chemistry*
chemical_list: D001896:Boron Compounds; D008024:Ligands; D010165:Palladium
keywords: CH activation; amino acids; borylation; palladium; synthetic methods