title: Modification of resin modified glass ionomer cement by addition of bioactive glass nanoparticles.
abstract: In the present study, sol-gel derived nanoparticle calcium silicate bioactive glass was added to the resin-modified light cure glass-ionomer cement to assess the influence of additional bioactive glass nanoparticles on the mechanical and biological properties of resin-modified glass-ionomer cement. The fabricated bioactive glass nanoparticles added resin-modified glass-ionomer cements (GICs) were immersed in the phosphate buffer solution for 28 days to mimic real condition for the mechanical properties. Resin-modified GICs containing 3, 5 and 10 % bioactive glass nanoparticles improved the flexural strength compared to the resin-modified glass-ionomer cement and the samples containing 15 and 20 % bioactive glass nanoparticles before and after immersing in the phosphate buffer solution. Characterization of the samples successfully expressed the cause of the critical condition for mechanical properties. Cell study clarified that resin-modified glass-ionomer cement with high concentrations of bioactive glass nanoparticles has higher cell viability and better cell morphology compare to control groups. The results for mechanical properties and toxicity approved that the considering in selection of an optimum condition would have been a more satisfying conclusion for this study.
authors.affiliation: Department of Dental and Biomedical Materials Science, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 812-8582, Japan. vala@nagasaki-u.ac.jp.
authors.forename: Alireza
authors.initials: A
authors.lastname: Valanezhad
authors.affiliation: Department of Applied Prosthodontics, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 812-8582, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Odatsu
authors.affiliation: Institute for Biomedical Research and Education, Yamaguchi University Science Research Center, 1-1-1 Minamiogu shi, Ube City, Yamaguchi, 755-8505, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Udoh
authors.affiliation: Department of Dental and Biomedical Materials Science, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 812-8582, Japan.
authors.forename: Takanobu
authors.initials: T
authors.lastname: Shiraishi
authors.affiliation: Department of Applied Prosthodontics, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 812-8582, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sawase
authors.affiliation: Department of Dental and Biomedical Materials Science, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 812-8582, Japan.
authors.forename: Ikuya
authors.initials: I
authors.lastname: Watanabe
mesh_terms: D005898:Glass; D005899:Glass Ionomer Cements; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D013052:Spectrometry, X-Ray Emission
chemical_list: D005899:Glass Ionomer Cements