title: Telomerase activity as a marker for differential diagnosis of pancreatic adenocarcinoma: a systematic review and meta-analysis.
abstract: BACKGROUND
  Studies evaluating the role of telomerase activity in pancreatic adenocarcinoma are inconsistent and a systemic review of the available literature may shed new light on this issue.
  
  
  OBJECTIVE
  To systematically review the usefulness of telomerase activity in distinguishing pancreatic cancer from other pancreatic diseases.
  
  
  METHODS
  A comprehensive search of the PubMed and Embase databases was conducted to identify eligible studies. Only studies evaluating telomerase activity in patients with suspected or previously diagnosed pancreatic adenocarcinomas versus nonpancreatic adenocarcinomas and published in English with a sufficient number of cases were included. The hierarchical summary receiver operating characteristic (HSROC) model was used to establish the potential value of telomerase activity in the diagnosis of pancreatic adenocarcinoma.
  
  
  RESULTS
  A total of 19 studies qualified for this meta-analysis. In distinguishing pancreatic adenocarcinoma from benign diseases, the pooled sensitivity and specificity of telomerase activity were 0.81 (95% CI, 0.68-0.90) and 0.97 (95% CI, 0.93-0.98), respectively; the diagnostic odds ratio (DOR) was 126.62 (95% CI, 49.94-320.99); beta was -1.16 (95% CI, -3.62-1.29), Z was -0.93, p was 0.35&gt;0.1, and lambda was 6.86 (95% CI, 1.01-12.70). In distinguishing pancreatic adenocarcinoma from chronic pancreatitis, the pooled sensitivity and specificity of telomerase activity were 0.77 (95% CI, 0.61-0.88) and 0.97 (95% CI, 0.91-0.99), respectively; DOR was 117.28 (95% CI, 32.25-426.53); beta was -0.38 (95% CI, -1.89-1.13), Z was -0.49, p was 0.62&gt;0.1, and lambda was 5.30 (95% CI, 3.37-7.24).
  
  
  CONCLUSIONS
  The present meta-analysis demonstrates that telomerase activity could be a useful biomarker for the differential diagnosis of pancreatic adenocarcinoma and benign pancreatic diseases.
authors.affiliation: Department of General Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang - PR China.
authors.forename: Huajian
authors.initials: H
authors.lastname: Gu
authors.affiliation: Department of Gynecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan - PR China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Xin
authors.affiliation: Department of General Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang - PR China.
authors.forename: Yaozhen
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Department of General Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang - PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang - PR China.
authors.forename: She
authors.initials: S
authors.lastname: Tian
authors.affiliation: Department of General Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang - PR China.
authors.forename: Chengyi
authors.initials: C
authors.lastname: Sun
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000201:enzymology* / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000473:pathology; D019098:Telomerase / Q000378:metabolism*
chemical_list: D019098:Telomerase