title: Role of serum polyunsaturated fatty acids in the development of colorectal cancer.
abstract: We aimed to investigate the role of serum levels of polyunsaturated fatty acid (PUFA) in the development of colorectal cancer (CRC). Serum levels of n-3 and n-6 PUFA in 69 healthy control (Ctrl), 62 benign colorectal polys (CRP) and 100 CRC patients were detected by gas chromatograph. The adjusted odds ratio (OR) by quartiles of n-3 and n-6 PUFA were analyzed. During the process of Ctrl to CRP, total n-3 PUFA (OR=0.159, P<0.001), total n-6 PUFA (OR=0.190, P<0.001), C20:5 n-3 (OR=0.263, P=0.030), C22:6 n-3 (OR=0.125, P<0.001), and C18:2 n-6 (OR=0.299, P=0.025) were inversely associated with CRP risk. The ratio of total n-6 PUFA and total n-3 PUFA (OR=4.667, P=0.002), and the ratio of C20:4 n-6 and (C20:5 n-3+C22:6 n-3) (OR=6.000, P<0.001) were positively associated with CRP risk. During the process of CRP to CRC, total n-3 PUFA (OR=4.059, P=0.007), total n-6 PUFA (OR=8.146, P<0.001), C22:6 n-3 (OR=3.789, P=0.048), and C18:2 n-6 (OR=3.667, P=0.045) were positively associated with CRC risk. The ratio of C20:4 n-6 and (C20:5 n-3+C22:6 n-3) (OR=0.588, P=0.001) was inversely associated with CRC. In conclusion, our results found that the total n-3 PUFA, C22:6 n-3, the total n-6 PUFA, C18:2 n-6, and the ratio of C20:4 n-6 and (C20:5 n-3 +C22:6 n-3) played controversy role in the process of CRP and the process of CRC, and may provide nutritional intervention suggestions for the clinical practice.
authors.affiliation: Core Laboratory of Translational Medicine, Chinese PLA General Hospital Beijing, China ; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Interventional Therapy Department, Peking University Cancer Hospital&Institute Beijing, China.
authors.forename: Pengjun
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Clinical Biochemistry, State Key Laboratory of Kidney Disease, Chinese PLA General Hospital Beijing, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Wen
authors.affiliation: Department of Clinical Biochemistry, State Key Laboratory of Kidney Disease, Chinese PLA General Hospital Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gu
authors.affiliation: Department of Nutrition, Chinese PLA General Hospital Beijing, China.
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Clinical Biochemistry, State Key Laboratory of Kidney Disease, Chinese PLA General Hospital Beijing, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Clinical Biochemistry, State Key Laboratory of Kidney Disease, Chinese PLA General Hospital Beijing, China.
authors.forename: Yulan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Clinical Biochemistry, State Key Laboratory of Kidney Disease, Chinese PLA General Hospital Beijing, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Clinical Biochemistry, State Key Laboratory of Kidney Disease, Chinese PLA General Hospital Beijing, China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Deng
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Interventional Therapy Department, Peking University Cancer Hospital&Institute Beijing, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Core Laboratory of Translational Medicine, Chinese PLA General Hospital Beijing, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Tian
keywords: Polyunsaturated fatty acids; colorectal cancer; colorectal polys; odds ratio