title: Uncoupling of Vascular Endothelial Growth Factor (VEGF) and Inducible Nitric Oxide Synthase (iNOS) in Gingival Tissue of Type 2 Diabetic Patients.
abstract: In this study, we investigate the relation between vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS) in periodontal disease of diabetic and non-diabetic individuals. We evaluated immunohistochemical VEGF and iNOS expressions in gingival biopsies from healthy individuals (no chronic periodontitis (CP)), patients with periodontitis alone (CP), patients with diabetes alone (DM) and diabetic patients with chronic periodontitis (DM + CP). We found a significant positive correlation between VEGF and iNOS expression in non-diabetic groups, but not in diabetic ones. Periodontal clinical parameters were not found to be significantly correlated with the inflammatory markers in no-CP, CP, and DM groups, whereas in DM + CP, positive and significant correlations were found between all the considered periodontal parameters and epithelial VEGF and endothelial iNOS. The uncoupling of VEGF and iNOS expression in diabetic individuals could allow a greater involvement of the markers in the inflammatory process of periodontitis.
authors.affiliation: Department of Clinic and Molecular Sciences-Histology, Polytechnic University of Marche, Via Tronto 10/a-60126 Torrette, Ancona, Italy. guendalina.lucarini@univpm.it.
authors.forename: Guendalina
authors.initials: G
authors.lastname: Lucarini
authors.affiliation: Department of Clinical and Molecular Sciences, Division of Endocrinology, School of Medicine, Polytechnic University of Marche, Ancona, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Tirabassi
authors.affiliation: Department of Biomedical Sciences and Public Health, Section of Pathologic Anatomy and Histopathology, Polytechnic University of Marche, Torrette, Ancona, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Zizzi
authors.affiliation: Department of Clinical and Molecular Sciences, Division of Endocrinology, School of Medicine, Polytechnic University of Marche, Ancona, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Balercia
authors.affiliation: Italian National Research Center on Aging (I.N.R.C.A), Ancona, Italy.
authors.forename: Alexia
authors.initials: A
authors.lastname: Quaranta
authors.affiliation: Department of Biomedical Sciences and Public Health, Section of Pathologic Anatomy and Histopathology, Polytechnic University of Marche, Torrette, Ancona, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Rubini
authors.affiliation: Department of Clinical Special and Dental Science, Periodontology, Polytechnic University of Marche, Ancona, Italy.
authors.forename: Simone Domenico
authors.initials: SD
authors.lastname: Aspriello
mesh_terms: D000368:Aged; D015415:Biomarkers; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005881:Gingiva / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009569:Nitric Oxide / Q000096:biosynthesis; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism*; D010510:Periodontal Diseases / Q000473:pathology*; D011446:Prospective Studies; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D009569:Nitric Oxide; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II
keywords: diabetes mellitus; inflammation; nitric oxide synthase; periodontitis; vascular endothelial growth factor a/analysis; wound healing