title: Simultaneously increased expression of microRNA-155 and suppressor of cytokine signaling 1 (SOCS1) gene in the peripheral blood mononuclear cells of patients with primary Sjögren's syndrome.
abstract: OBJECTIVE
  The microRNA-155 (miR-155) is regarded as a central modulator of T-cell responses and could be a potential therapeutic target for certain inflammatory diseases. In our present study we analyzed the expression rate of miR-155 and its functionally linked gene, the suppressor gene of cytokine signaling 1 (SOCS1) in primary Sjögren's syndrome (pSS).
  
  
  METHODS
  We enrolled 23 pSS patients and 10 healthy individuals in the study. The expression of miR-155 and SOCS1 gene were measured by real-time polymerase chain reaction.
  
  
  RESULTS
  We observed the over-expression of miR-155 in the peripheral mononuclear cells of patients with pSS. Surprisingly, SOCS1 gene was also over-expressed in pSS patients.
  
  
  CONCLUSIONS
  This unanticipated phenomenon might be a laboratory characteristic of Sjögren's syndrome, and presumably a consequence of the noteworthy difference in the pSS immune system reacting with Epstein-Barr virus.
authors.affiliation: Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: Ji-Qing
authors.initials: JQ
authors.lastname: Chen
authors.affiliation: Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: Erika
authors.initials: E
authors.lastname: Zilahi
authors.affiliation: Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Papp
authors.affiliation: Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: Sándor
authors.initials: S
authors.lastname: Sipka
authors.affiliation: Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: Margit
authors.identifier: http://orcid.org/0000-0002-4698-3351
authors.initials: M
authors.lastname: Zeher
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D012859:Sjogren's Syndrome / Q000097:blood* / Q000175:diagnosis / Q000235:genetics; D000071222:Suppressor of Cytokine Signaling 1 Protein / Q000097:blood* / Q000235:genetics; D015854:Up-Regulation
chemical_list: D005819:Genetic Markers; C524942:MIRN155 microRNA, human; D035683:MicroRNAs; C108944:SOCS1 protein, human; D000071222:Suppressor of Cytokine Signaling 1 Protein
keywords: microRNA-155 (miR-155); primary Sjögren's syndrome (pSS); suppressor of cytokine signaling 1 (SOCS1)