title: DNA Methylation, Mitochondria, and Programmed Aging.
abstract: DNA methylation is a key epigenetic process involved in the regulation of nuclear gene expression. Progress in the study of genomic DNA methylation led to the precise identification of methylation sites reflecting biological age of cells and tissues. However, the functional significance of mitochondrial DNA (mtDNA) methylation remains unknown. Growing evidence suggests that mtDNA methylation is linked to aging and oxidative stress. This mini-review summarizes information about the methylation of nuclear and mtDNA in mammals, indicating the connection of these processes to programmed aging.
authors.affiliation: Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, 119991, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Zinovkina
authors.forename: R A
authors.initials: RA
authors.lastname: Zinovkin
mesh_terms: D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D019175:DNA Methylation; D004272:DNA, Mitochondrial / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D057890:Epigenomics; D006801:Humans; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism; D018384:Oxidative Stress / Q000235:genetics
chemical_list: D004272:DNA, Mitochondrial