title: Depression and anxiety in ovarian cancer: a systematic review and meta-analysis of prevalence rates.
abstract: OBJECTIVE
  To systematically review the literature pertaining to the prevalence of depression and anxiety in patients with ovarian cancer as a function of treatment stage.
  
  
  METHODS
  Systematic review and meta-analysis.
  
  
  METHODS
  3623 patients with ovarian cancer from primary research investigations.
  
  
  METHODS
  The prevalence of depression and anxiety in patients with ovarian cancer as a function of treatment stage.
  
  
  RESULTS
  We identified 24 full journal articles that met the inclusion criteria for entry into the meta-analysis resulting in a pooled sample size of 3623 patients. The meta-analysis of prevalence rates identified pretreatment, on-treatment and post-treatment depression prevalences of 25.34% (CI 22.79% to 28.07%), 22.99% (CI 19.85% to 26.46%) and 12.71% (CI 10.14% to 15.79%), respectively. Pretreatment, on-treatment and post-treatment anxiety prevalences were 19.12% (CI 17.11% to 21.30%), 26.23% (CI 22.30% to 30.56%) and 27.09% (CI 23.10% to 31.49%).
  
  
  CONCLUSIONS
  Our findings suggest that the prevalence of depression and anxiety in women with ovarian cancer, across the treatment spectrum, is significantly greater than in the healthy female population. With the growing emphasis on improving the management of survivorship and quality of life, we conclude that further research is warranted to ensure psychological distress in ovarian cancer is not underdiagnosed and undertreated.
authors.affiliation: Faculty of Medicine, Department of Primary Care and Population Sciences, University of Southampton, Southampton, UK.
authors.forename: Sam
authors.initials: S
authors.lastname: Watts
authors.affiliation: Department of Mathematics, University of Southampton, Southampton, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Prescott
authors.affiliation: Department of Urology, Royal Shrewsbury Hospitals NHS Trust, Shrewsbury, UK.
authors.forename: Jessica
authors.initials: J
authors.lastname: Mason
authors.affiliation: Faculty of Medicine, University of Southampton, Southampton, UK.
authors.forename: Natalie
authors.initials: N
authors.lastname: McLeod
authors.affiliation: Faculty of Medicine, Department of Primary Care and Population Sciences, University of Southampton, Southampton, UK.
authors.forename: George
authors.initials: G
authors.lastname: Lewith
mesh_terms: D001007:Anxiety / Q000453:epidemiology*; D003863:Depression / Q000453:epidemiology*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000523:psychology* / Q000628:therapy; D015995:Prevalence; D011795:Surveys and Questionnaires
keywords: MENTAL HEALTH