title: Pyrrole-Imidazole Polyamides: Automated Solid-Phase Synthesis.
abstract: In this unit, the fully automated solid-phase synthetic strategy of hairpin Py-Im polyamides is described using triphosgene (BTC) as a coupling agent. This automated methodology is compatible with all the typical building blocks, enabling the facile synthesis of polyamide libraries in 9% to 20% yield in 3 days.
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, People's Republic of China.
authors.forename: Lijing
authors.initials: L
authors.lastname: Fang
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, People's Republic of China.
authors.forename: Zhengyin
authors.initials: Z
authors.lastname: Pan
authors.affiliation: Department of Chemistry, University of Leicester, Leicester, United Kingdom.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Cullis
authors.affiliation: Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, United Kingdom.
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Burley
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, People's Republic of China.
authors.forename: Wu
authors.initials: W
authors.lastname: Su
mesh_terms: D001331:Automation; D007093:Imidazoles / Q000737:chemistry*; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*
chemical_list: D007093:Imidazoles; D011073:Polyamines; D011758:Pyrroles; C029899:imidazole
keywords: DNA; Py-Im polyamide; automated synthesis; minor groove; solid-phase synthesis; triphosgene