title: Comparison of Failure Patterns Between Conventional and Intensity-modulated Radiotherapy for Stage III and IV Head and Neck Squamous Cell Carcinoma.
abstract: BACKGROUND
  We compared the patterns of failure between 3-dimensional radiotherapy (3D-RT) and intensity-modulated radiotherapy (IMRT) for head and neck squamous cell carcinoma (HNSCC).
  
  
  METHODS
  We reviewed the medical records of 49 patients with stage III-IV HNSCC treated with concurrent chemoradiotherapy. The treatment outcome, patterns of failure, and toxicities were compared between 3D-RT and IMRT.
  
  
  RESULTS
  There were 13 locoregional recurrences as initial failure sites. Eight recurrences were local, three were regional, and two were both local and regional. The recurrence pattern did not differ between the 3D-RT- and IMRT-treated groups, while toxicities were reduced in the IMRT-treated group. All recurrences were within the high-risk planning target volume except for one case in IMRT.
  
  
  CONCLUSIONS
  IMRT did not increase the risk of locoregional recurrence neither did it change the pattern of failure in patients with stage III-IV locally advanced HNSCC, although it did reduce toxicities.
authors.affiliation: Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Song
authors.affiliation: Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors.forename: Bae-Kwon
authors.initials: BK
authors.lastname: Jeong
authors.affiliation: Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea.
authors.forename: Hoon-Sik
authors.initials: HS
authors.lastname: Choi
authors.affiliation: Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors.forename: Hojin
authors.initials: H
authors.lastname: Jeong
authors.affiliation: Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors.forename: Myoung Hee
authors.initials: MH
authors.lastname: Kang
authors.affiliation: Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors.forename: Jung Hun
authors.initials: JH
authors.lastname: Kang
authors.affiliation: Department of Otorhinolaryngology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors.forename: Jin Pyeong
authors.initials: JP
authors.lastname: Kim
authors.affiliation: Department of Otorhinolaryngology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors.forename: Jung Je
authors.initials: JJ
authors.lastname: Park
authors.affiliation: Department of Otorhinolaryngology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea.
authors.forename: Seung Hoon
authors.initials: SH
authors.lastname: Woo
authors.affiliation: Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Hong Seok
authors.initials: HS
authors.lastname: Jang
authors.affiliation: Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Byung Ock
authors.initials: BO
authors.lastname: Choi
authors.affiliation: Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea jsk92@gnu.ac.kr.
authors.forename: Ki Mun
authors.initials: KM
authors.lastname: Kang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000627:therapeutic use; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin
keywords: Head and neck cancer; intensity-modulated radiotherapy; patterns of failure; radiotherapy