title: Behavioral Microbiomics: A Multi-Dimensional Approach to Microbial Influence on Behavior.
abstract: The role of microbes as a part of animal systems has historically been an under-appreciated aspect of animal life histories. Recently, evidence has emerged that microbes have wide-ranging influences on animal behavior. Elucidating the complex relationships between host-microbe interactions and behavior requires an expanded ecological perspective, involving the host, the microbiome and the environment; which, in combination, is termed the holobiont. We begin by seeking insights from the literature on host-parasite interactions, then expand to consider networks of interactions between members of the microbial community. A central aspect of the environment is host nutrition. We describe how interactions between the nutrient environment, the metabolic and behavioral responses of the host and the microbiome can be studied using an integrative framework called nutritional geometry, which integrates and maps multiple aspects of the host and microbial response in multidimensional nutrient intake spaces.
authors.affiliation: Charles Perkins Centre, The University of Sydney , Sydney, NSW, Australia ; School of Biological Sciences, The University of Sydney , Sydney, NSW, Australia ; Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School , Boston, MA, USA.
authors.forename: Adam C-N
authors.initials: AC
authors.lastname: Wong
authors.affiliation: Charles Perkins Centre, The University of Sydney , Sydney, NSW, Australia ; School of Biological Sciences, The University of Sydney , Sydney, NSW, Australia ; School of Molecular Bioscience, The University of Sydney , Sydney, NSW, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Holmes
authors.affiliation: Charles Perkins Centre, The University of Sydney , Sydney, NSW, Australia ; School of Biological Sciences, The University of Sydney , Sydney, NSW, Australia ; Department of Biological Sciences, Macquarie University , Sydney, NSW, Australia.
authors.forename: Fleur
authors.initials: F
authors.lastname: Ponton
authors.affiliation: Centre National de la Recherche Scientifique, Centre de Recherches sur la Cognition Animale , Toulouse, France ; Université Paul Sabatier, Centre de Recherches sur la Cognition Animale , Toulouse, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Lihoreau
authors.affiliation: Lancaster Environment Centre, Lancaster University , Lancaster, UK.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Wilson
authors.affiliation: Charles Perkins Centre, The University of Sydney , Sydney, NSW, Australia ; School of Biological Sciences, The University of Sydney , Sydney, NSW, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Raubenheimer
authors.affiliation: Charles Perkins Centre, The University of Sydney , Sydney, NSW, Australia ; School of Biological Sciences, The University of Sydney , Sydney, NSW, Australia.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Simpson
keywords: behavior; holobiont; microbiome; nutrition; symbiosis