title: Anticancer Potencies of Pt(II) - and Pd(II)-linked M2L4 Coordination Capsules with Improved Selectivity.
abstract: Pt(II) - and Pd(II)-linked M2 L4 coordination capsules, providing a confined cavity encircled by polyaromatic frameworks, exhibit anticancer activities superior to cisplatin against two types of leukemic cells (HL-60 and SKW-3) and pronounced toxicity against cisplatin-resistant cells (HL-60/CDDP). Notably, the cytotoxic selectivities of the Pt(II) and Pd(II) capsules toward cancerous cells are up to 5.3-fold higher than that of cisplatin, as estimated through the non-malignant/malignant-cells toxicity ratio employing normal kidney cells (HEK-293). In addition, the anticancer activity of the coordination capsules can be easily altered upon encapsulation of organic guest molecules.
authors.affiliation: Faculty of Chemistry and Pharmacy, Sofia University, 1, J. Bourchier blvd., Sofia, 1164, Bulgaria. Ahmedova@chem.uni-sofia.bg.
authors.forename: Anife
authors.initials: A
authors.lastname: Ahmedova
authors.affiliation: Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, Sofia, 1000, Bulgaria.
authors.forename: Denitsa
authors.initials: D
authors.lastname: Momekova
authors.affiliation: Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama, 226-8503, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamashina
authors.affiliation: NMR Laboratory, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 9, Sofia, 1113, Bulgaria.
authors.forename: Pavletta
authors.initials: P
authors.lastname: Shestakova
authors.affiliation: Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, Sofia, 1000, Bulgaria.
authors.forename: Georgi
authors.initials: G
authors.lastname: Momekov
authors.affiliation: Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama, 226-8503, Japan.
authors.forename: Munetaka
authors.initials: M
authors.lastname: Akita
authors.affiliation: Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama, 226-8503, Japan. yoshizawa.m.ac@m.titech.ac.jp.
authors.forename: Michito
authors.initials: M
authors.lastname: Yoshizawa
mesh_terms: D000873:Anthracenes / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics*; D002214:Capsules; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D057809:HEK293 Cells; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008958:Models, Molecular; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000873:Anthracenes; D000970:Antineoplastic Agents; D002214:Capsules; D056831:Coordination Complexes; D009944:Organoplatinum Compounds; D010165:Palladium; C034020:anthracene; D002945:Cisplatin
keywords: anticancer activity; cancer; cisplatin; coordination capsules; encapsulation; platinum ion