title: pH and Glutathione Dual-Responsive Dynamic Cross-Linked Supramolecular Network on Mesoporous Silica Nanoparticles for Controlled Anticancer Drug Release.
abstract: A dynamic cross-linked supramolecular network of poly(glycidyl methacrylate)s derivative chains was constructed on mesoporous silica nanoparticles via disulfide bond and ion-dipole interactions between cucurbit[7]urils and protonated diamines in the polymer chains. This kind of multifunctional organic-inorganic hybrid material with pH- and glutathione- (GSH-) stimuli responsiveness can be applied to anticancer drug delivery and controlled release. Good release performance toward doxorubicin hydrochloride (DOX) was achieved under the simulative tumor intracellular environment (pH = 5.0, CGSH = 2-10 mM). Significantly, the release amount of DOX increased upon lowering the solution pH value and increasing the concentration of GSH, as demonstrated by a series of controlled release experiments. Furthermore, the DOX-loaded hybrid nanomaterials displayed apparent cell-growth inhibition effects to cancer cell lines, as evidenced by MTT assay and confocal laser scanning microscopy.
authors.forename: Qing-Lan
authors.initials: QL
authors.lastname: Li
authors.forename: Shi-Han
authors.initials: SH
authors.lastname: Xu
authors.forename: Hang
authors.initials: H
authors.lastname: Zhou
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Biao
authors.initials: B
authors.lastname: Dong
authors.affiliation: School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Material Science and Engineering, Tianjin University of Technology , Tianjin 300384, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
authors.forename: Jun
authors.initials: J
authors.lastname: Tang
authors.forename: Ying-Wei
authors.initials: YW
authors.lastname: Yang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000494:pharmacology; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D005978:Glutathione / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D012822:Silicon Dioxide; D004317:Doxorubicin; D005978:Glutathione
keywords: controlled release; cucurbit[7]uril; doxorubicin hydrochloride; glutathione; mesoporous silica nanoparticles; pH; poly(glycidyl methacrylate)s