title: The Interleaved Genome.
abstract: Eukaryotic genomes are pervasively transcribed but until recently this noncoding transcription was considered to be simply noise. Noncoding transcription units overlap with genes and genes overlap other genes, meaning genomes are extensively interleaved. Experimental interventions reveal high degrees of interdependency between these transcription units, which have been co-opted as gene regulatory mechanisms. The precise outcome depends on the relative orientation of the transcription units and whether two overlapping transcription events are contemporaneous or not, but generally involves chromatin-based changes. Thus transcription itself regulates transcription initiation or repression at many regions of the genome.
authors.affiliation: Department of Biochemistry, South Parks Road, Oxford, OX1 3QU, UK. Electronic address: jane.mellor@bioch.ox.ac.uk.
authors.forename: Jane
authors.initials: J
authors.lastname: Mellor
authors.affiliation: Department of Biochemistry, South Parks Road, Oxford, OX1 3QU, UK.
authors.forename: Ronja
authors.initials: R
authors.lastname: Woloszczuk
authors.affiliation: Department of Biochemistry, South Parks Road, Oxford, OX1 3QU, UK.
authors.forename: Françoise S
authors.initials: FS
authors.lastname: Howe
mesh_terms: D005057:Eukaryotic Cells / Q000502:physiology*; D016678:Genome; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors