title: GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo.
abstract: An effective immune system depends upon regulation of lymphocyte function and homeostasis. In recent years, members of the GTPases of the immunity associated protein (GIMAP) family were proposed to regulate T cell homeostasis. In contrast, little is known about their function and mode of action in B cells. We used a combination of transgenic mice and in vivo and in vitro techniques to conditionally and electively ablate GIMAP1 in resting and activated peripheral B cells. Our data suggest that GIMAP1 is absolutely essential for the survival of peripheral B cells, irrespective of their activation state. Together with recent data showing increased expression of GIMAP1 in B cell lymphomas, our work points to the possible potential of GIMAP1 as a target for manipulation in a variety of B cell-mediated diseases.
authors.affiliation: Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, United Kingdom; and.
authors.forename: Louise M C
authors.initials: LM
authors.lastname: Webb
authors.affiliation: Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, United Kingdom; and.
authors.forename: Preeta
authors.initials: P
authors.lastname: Datta
authors.affiliation: Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, United Kingdom; and.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Bell
authors.affiliation: Research Institute for Biomedical Sciences, Tokyo University of Science, Yamazaki 2669, Noda, Chiba 278-0022, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kitamura
authors.affiliation: Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, United Kingdom; and.
authors.forename: Martin
authors.initials: M
authors.lastname: Turner
authors.affiliation: Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, United Kingdom; and geoff.butcher@babraham.ac.uk.
authors.forename: Geoffrey W
authors.identifier: http://orcid.org/0000-0002-3423-7124
authors.initials: GW
authors.lastname: Butcher
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002470:Cell Survival / Q000235:genetics / Q000276:immunology; D002478:Cells, Cultured; D019204:GTP-Binding Proteins / Q000235:genetics / Q000276:immunology*; D018858:Germinal Center / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D016393:Lymphoma, B-Cell / Q000473:pathology; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008822:Mice, Transgenic
chemical_list: C103678:Imap38 protein, mouse; D008565:Membrane Proteins; D019204:GTP-Binding Proteins