title: Genetic variation in vitamin D-related genes and risk of breast cancer among women of European and East Asian descent.
abstract: Studies of vitamin D-related genetic variants and breast cancer have been inconsistent. This study aimed to investigate associations of vitamin D-related polymorphisms and breast cancer risk among European and East Asian women and potential interactions with menopausal status and breast tumour subtypes. Data from a case-control study of breast cancer (1037 cases and 1050 controls) were used to assess relationships between 21 polymorphisms in two vitamin D-related genes (GC and VDR) and breast cancer risk. Odds ratios were calculated in stratified analyses of European and East Asian women, using logistic regression in an additive genetic model. An interaction term was used to explore modification by menopausal status. Polytomous regression was used to assess heterogeneity by breast tumour subtype. False discovery rate adjustments were conducted to account for multiple testing. No association was observed between GC or VDR polymorphisms and breast cancer risk. Modification of these relationships by menopausal status was observed for select polymorphisms in both Europeans (VDR rs4328262 and rs11168292) and East Asians (GC rs7041 and VDR rs11168287). Heterogeneity by tumour subtype was seen for three VDR polymorphisms (rs1544410, rs7967152 and rs2239186) among Europeans, in which associations with ER-/PR-/HER2+ tumours, but not with other subtypes, were observed. In conclusion, associations between vitamin D-related genetic variants and breast cancer were not observed overall, although the relationships between vitamin D pathway polymorphisms and breast cancer may be modified by menopausal status and breast tumour subtype.
authors.affiliation: Department of Public Health Sciences and Cancer Research Institute, Queen's University, Kingston, ON, Canada.
authors.forename: Joy
authors.initials: J
authors.lastname: Shi
authors.affiliation: Alberta Cancer Prevention Legacy Fund, Alberta Health Services, Calgary, AB, Canada.
authors.forename: Anne
authors.initials: A
authors.lastname: Grundy
authors.affiliation: Department of Public Health Sciences and Cancer Research Institute, Queen's University, Kingston, ON, Canada.
authors.forename: Harriet
authors.initials: H
authors.lastname: Richardson
authors.affiliation: Department of Environmental and Occupational Health, Drexel University, Philadelphia, PA, USA.
authors.forename: Igor
authors.initials: I
authors.lastname: Burstyn
authors.affiliation: Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada.
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Schuetz
authors.affiliation: Department of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Lohrisch
authors.affiliation: Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.
authors.forename: Sandip K
authors.initials: SK
authors.lastname: SenGupta
authors.affiliation: Department of Cancer Control Research, British Columbia Cancer Agency, Vancouver, BC, Canada.
authors.forename: Agnes S
authors.initials: AS
authors.lastname: Lai
authors.affiliation: Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada.|Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
authors.forename: Angela
authors.initials: A
authors.lastname: Brooks-Wilson
authors.affiliation: Department of Cancer Control Research, British Columbia Cancer Agency, Vancouver, BC, Canada.|School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
authors.forename: John J
authors.initials: JJ
authors.lastname: Spinelli
authors.affiliation: Department of Public Health Sciences and Cancer Research Institute, Queen's University, Kingston, ON, Canada. aronson@queensu.ca.|Division of Cancer Care and Epidemiology, Queen's Cancer Research Institute, 10 Stuart Street, Kingston, ON, K7L 3N6, Canada. aronson@queensu.ca.
authors.forename: Kristan J
authors.initials: KJ
authors.lastname: Aronson
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors; D014807:Vitamin D / Q000235:genetics* / Q000378:metabolism; D014809:Vitamin D-Binding Protein / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human; D014809:Vitamin D-Binding Protein; D014807:Vitamin D
keywords: Breast cancer; Case–control; Polymorphisms; Tumour subtype; Vitamin D-related genes