title: The Biology of Pulmonary Metastasis.
abstract: The process of metastasis relies on a series of stochastic and sequential steps, with selective pressure exerted on a large number of genetically volatile cancer cells to produce a very small fraction of tumor cells with the ability to navigate the transition from primary tumor cell to end-organ metastasis. This process is intricately determined by cell-microenvironment interactions, the mechanistic understanding of which is steadily increasing. The continued elucidation of pathways that govern these interactions offers potential therapeutic options to patients with advanced disease.
authors.affiliation: Department of Surgery, Duke University, Duke University Medical Center, 4. DUMC Box 3627, Durham, NC 27710, USA.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Scott
authors.affiliation: Duke University, Durham, NC 27710, USA. Electronic address: david.harpole@dm.duke.edu.
authors.forename: David H
authors.initials: DH
authors.lastname: Harpole
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D002470:Cell Survival; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology / Q000556:secondary; D009362:Neoplasm Metastasis; D059016:Tumor Microenvironment
keywords: Metastasis; Pulmonary metastasis; Seed and soil hypothesis