title: Biological network analysis with CentiScaPe: centralities and experimental dataset integration.
abstract: The growing dimension and complexity of the available experimental data generating biological networks have increased the need for tools that help in categorizing nodes by their topological relevance. Here we present CentiScaPe, a Cytoscape app specifically designed to calculate centrality indexes used for the identification of the most important nodes in a network. CentiScaPe is a comprehensive suite of algorithms dedicated to network nodes centrality analysis, computing several centralities for undirected, directed and weighted networks. The results of the topological analysis can be integrated with data set from lab experiments, like expression or phosphorylation levels for each protein represented in the network. Our app opens new perspectives in the analysis of biological networks, since the integration of topological analysis with lab experimental data enhance the predictive power of the bioinformatics analysis.
authors.affiliation: Center for Biomedical Computing, University of Verona, Verona, 37134, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Scardoni
authors.affiliation: Center for Biomedical Computing, University of Verona, Verona, 37134, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Tosadori
authors.affiliation: Birla Institute of Technology & Science, Goa, 403726, India.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Faizan
authors.affiliation: Department of Computer Science, University of Verona, Verona, 37134, Italy.
authors.forename: Fausto
authors.initials: F
authors.lastname: Spoto
authors.affiliation: Center for Biomedical Computing, University of Verona, Verona, 37134, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Fabbri
authors.affiliation: Center for Biomedical Computing, University of Verona, Verona, 37134, Italy ; Department of Pathology and Diagnostics, University of Verona, Verona, 37134, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Laudanna
keywords: Cytoscape; centrality indexes; networks; nodes; topological analysis