title: COX-2 gene variants in bipolar disorder-I.
abstract: BACKGROUND
  Bipolar disorder-I (BD-I) is a complex illness, and multiple genes and environmental factors determine its pathogenesis. Several studies have ascertained that BD-I and inflammation are linked through shared genetic polymorphisms and gene expression, as well as altered cytokine levels. COX-2 gene polymorphisms affecting COX-2 levels may be associated with BD-I by altering the inflammatory response.
  
  
  METHODS
  We investigated COX-2-765G→C and COX-2-1195A→G gene polymorphisms, which might be related for BD-I. The present analyses are based on 180 subjects with bipolar I disorder-I and 170 non-bipolar subjects. Genotyping of COX-2 gene polymorphisms (COX-2-765G→C, COX-2-1195A→G) were detected by PCR-RFLP.
  
  
  RESULTS
  We found a positive association of COX-2 gene variants for development of BD-I. There were statistically significant differences in COX-2-1195A→G genotypes and alleles between the controls and patients (p:0.000; p:0.000). The indivuals with COX-2-1195A→G AA genotype had seems to be associated for BD-I (p:0.000).
  
  
  CONCLUSIONS
  It seems that there is a protective role of COX-2-1195A→G G+ genotype against BD-I (p:0.000). In addition, there was a weak linkage disequilibrium between COX-2-765G→C and COX-2-1195A→G polymorphisms. Our findings suggest that COX-2-1195A→G AA genotype may faciliate the development of BD-I.
authors.affiliation: Department of Molecular Medicine, Institute for Experimental Medicine Research, Istanbul University, Vakif Gureba Cad. Capa 34390, Istanbul, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Ozdemircan
authors.forename: Selcuk
authors.initials: S
authors.lastname: Dasdemir
authors.forename: Cem Ismail
authors.initials: CI
authors.lastname: Kucukali
authors.forename: Elif Sinem
authors.initials: ES
authors.lastname: Bireller
authors.forename: Hamdi
authors.initials: H
authors.lastname: Ozturk
authors.forename: Bedia
authors.initials: B
authors.lastname: Cakmakoglu
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics*; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D051546:Cyclooxygenase 2