title: Recovery Potential After Acute Stroke.
abstract: In acute stroke, the major factor for recovery is the early use of thrombolysis aimed at arterial recanalization and reperfusion of ischemic brain tissue. Subsequently, neurorehabilitative training critically improves clinical recovery due to augmention of postlesional plasticity. Neuroimaging and electrophysiology studies have revealed that the location and volume of the stroke lesion, the affection of nerve fiber tracts, as well as functional and structural changes in the perilesional tissue and in large-scale bihemispheric networks are relevant biomarkers of post-stroke recovery. However, associated disorders, such as mood disorders, epilepsy, and neurodegenerative diseases, may induce secondary cerebral changes or aggravate the functional deficits and, thereby, compromise the potential for recovery.
authors.affiliation: Department of Neurology, Centre of Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Heinrich-Heine-University Düsseldorf , Düsseldorf , Germany ; Biomedical Research Centre, Heinrich-Heine-University Düsseldorf , Düsseldorf , Germany ; Florey Institute of Neuroscience and Mental Health, University of Melbourne , Parkville, VIC , Australia.
authors.forename: Rüdiger J
authors.initials: RJ
authors.lastname: Seitz
authors.affiliation: Florey Institute of Neuroscience and Mental Health, University of Melbourne , Parkville, VIC , Australia.
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Donnan
keywords: cerebral ischemia; infarct location; network reorganization; neurorehabilitative training; perilesional plasticity; recovery; stroke associated disturbances; thrombolysis