title: Assessment of Tumor Angiogenesis: Dynamic Contrast-enhanced MR Imaging and Beyond.
abstract: Dynamic contrast-enhanced (DCE) MR imaging is used increasingly often to evaluate tumor angiogenesis and the efficacy of antiangiogenic drugs. In clinical practice DCE-MR imaging applications are largely centered on lesion detection, characterization, and localization. In research, DCE-MR imaging helps inform decision making in early-phase clinical trials by showing efficacy and by selecting dose and schedule. However, the role of these techniques in patient selection is uncertain. Future research is required to optimize existing DCE-MR imaging methods and to fully validate these biomarkers for wider use in patient care and in drug development.
authors.affiliation: Cancer Research UK and EPSRC Cancer Imaging Centre, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Salem
authors.affiliation: Cancer Research UK and EPSRC Cancer Imaging Centre, University of Manchester, Oxford Road, Manchester M13 9PT, UK. Electronic address: james.o'connor@manchester.ac.uk.
authors.forename: James P B
authors.initials: JPB
authors.lastname: O'Connor
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D003287:Contrast Media / Q000493:pharmacokinetics*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000639:trends*; D057054:Molecular Imaging / Q000639:trends; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000378:metabolism* / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D003287:Contrast Media
keywords: Angiogenesis; Biomarker; Clinical trials; DCE-MR imaging; Diagnosis; Quantitative imaging