title: Role of annexin A6 in cancer.
abstract: Annexin A6 (AnxA6) is a member of a conserved superfamily of Ca2+-dependent membrane-binding annexin proteins. It participates in membrane and cytoskeleton organization, cholesterol homeostasis, membrane trafficking, cell adhesion and signal transduction. The expression levels of AnxA6 are closely associated with melanoma, cervical cancer, epithelial carcinoma, breast cancer, gastric cancer, prostate cancer, acute lymphoblastic leukemia, chronic myeloid leukemia, large-cell lymphoma and myeloma. AnxA6 exhibits dual functions in cancer, acting either as a tumor suppressor or promoter, depending on the type of cancer and the degree of malignancy. In several types of cancer, AnxA6 acts via Ras, Ras/MAPK and/or FAK/PI3K signaling pathways by mainly mediating PKCα, p120GAP, Bcr-Abl and YY1. In the present review, the roles of AnxA6 in different types of cancer are summarized.
authors.affiliation: Department of Biotechnology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
authors.forename: Houbao
authors.initials: H
authors.lastname: Qi
authors.affiliation: Department of Biochemistry, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
authors.forename: Shuqing
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Biotechnology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Guo
authors.affiliation: Department of Biotechnology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
authors.forename: Jiasheng
authors.initials: J
authors.lastname: Wang
authors.affiliation: Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
authors.forename: Frederick T
authors.initials: FT
authors.lastname: Greenaway
authors.affiliation: Department of Biotechnology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
authors.forename: Ming-Zhong
authors.initials: MZ
authors.lastname: Sun
keywords: annexin A6; biomarker; cancer; malignancy; tumor promoter; tumor suppressor