title: A motor relay on ciliary tracks.
abstract: A powerful combination of two-colour imaging in vivo, Fourier-filtered kymography and simulations provides a high-resolution view of kinesin-2 transport dynamics in cilia. This study reveals heterotrimeric kinesin-II as an 'obstacle-course runner' and homodimeric OSM-3 (KIF17) as a 'long-distance runner', and elucidates the 'baton handoff' between these two kinesin-2 motors on the microtubule track.
authors.affiliation: Rutgers University, Human Genetics Institute and Department of Genetics, 145 Bevier Road, Piscataway, New Jersey 08854, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: O'Hagan
authors.affiliation: Rutgers University, Human Genetics Institute and Department of Genetics, 145 Bevier Road, Piscataway, New Jersey 08854, USA.
authors.forename: Maureen M
authors.initials: MM
authors.lastname: Barr
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D002923:Cilia / Q000378:metabolism*; D016547:Kinesins / Q000378:metabolism*
chemical_list: D029742:Caenorhabditis elegans Proteins; D016547:Kinesins