title: Changes in blood glucose level during and after light sedations using propofol-fentanyl and midazolam-fentanyl in diabetic patients who underwent cataract surgery.
abstract: BACKGROUND
  Surgeries may trigger the stress response which leads to changes in blood glucose level, and studies suggest that different sedation and anesthesia methods have different effects on blood glucose level. The aim of this study was to investigate changes of blood glucose levels in diabetic patients and compare them in two sedation methods of propofol + fentanyl and midazolam + fentanyl.
  
  
  METHODS
  Totally, 80 diabetic candidates for cataract surgery who had all the inclusion criteria, underwent cataract surgery using two methods of propofol (1 mg/kg/h) + fentanyl (2 μg/kg) (Group P) and midazolam (0.03 mg/kg) + fentanyl (2 μg/kg) (Group M) for light sedation. In the end, 70 patients (Group P n = 35 and Group M n = 35) remained in the study. Patients' blood glucose levels, vital signs, and hemodynamic data were assessed 30 min prior to the surgery, each 15 min during surgery and at the end of surgery.
  
  
  RESULTS
  Hemodynamic parameters did not have a statistically significant difference between the two groups mean blood glucose level in Group M was 149.15 mg/dl and in Group P was 149.2 mg/dl, and based on repeated measures analysis of variance test, significant differences were not observed between the two groups (P = 0.99). T-test showed no significant differences in the blood glucose level at any time of the study between the two groups.
  
  
  CONCLUSIONS
  Light sedation methods of propofol + fentanyl and midazolam + fentanyl did not have any differences in alteration of blood glucose level.
authors.affiliation: School of Medicine, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Pooyan
authors.initials: P
authors.lastname: Khalighinejad
authors.affiliation: Department of Anesthesiology, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Rahimi
authors.affiliation: Department of Anesthesiology, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Khosro
authors.initials: K
authors.lastname: Naghibi
authors.affiliation: School of Medicine, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Negar
authors.initials: N
authors.lastname: Niknam
keywords: Blood glucose; diabetes mellitus; fentanyl; midazolam; propofol