title: Omentin serum concentration and hepatic expression in chronic hepatitis C patients - together or apart?
abstract: Chronic hepatitis C (CHC) is accompanied by numerous metabolic disorders, partially associated with altered adipokine system regulation. Omentin (intelectin-1) is a novel adipokine known to play a pivotal role in metabolic regulation in CHC. In a group of 63 CHC patients (29 men/34 women) infected with genotype 1b, aged 6.6 ± 14.6 years, serum omentin levels and its gene expression in liver tissue were examined and their association with metabolic and histopathological features was assessed. Serum omentin levels were significantly higher in CHC patients compared to controls (p < 0.001), regardless of sex, body mass index (BMI), insulin sensitivity and lipid concentrations. There was no correlation between serum omentin and omentin hepatic expression. Neither parameter was associated with any histological features. Serum omentin in non-obese CHC patients seems not to be related to metabolic disorders or liver pathology. Omentin hepatic expression shows no relationship with either serum omentin levels or histopathological features. This suggests different mechanisms regulating circulating omentin concentration and omentin hepatic expression in CHC.
authors.affiliation: Michał Kukla, Medical University of Silesia, Department of Gastroenterology and Hepatology, Medyków 14, 40-752 Katowice, tel. +48 32 789 44 01, e-mail: kuklamich@poczta.onet.pl.
authors.forename: Michał
authors.initials: M
authors.lastname: Kukla
authors.forename: Marek
authors.initials: M
authors.lastname: Waluga
authors.forename: Brygida
authors.initials: B
authors.lastname: Adamek
authors.forename: Marzena
authors.initials: M
authors.lastname: Zalewska-Ziob
authors.forename: Janusz
authors.initials: J
authors.lastname: Kasperczyk
authors.forename: Aandrzej
authors.initials: A
authors.lastname: Gabriel
authors.forename: Rafał J
authors.initials: RJ
authors.lastname: Bułdak
authors.forename: Barbara
authors.initials: B
authors.lastname: Sobala-Szczygieł
authors.forename: Lucjan
authors.initials: L
authors.lastname: Kępa
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Ziora
authors.forename: Krystyna
authors.initials: K
authors.lastname: Żwirska-Korczala
authors.forename: Edward
authors.initials: E
authors.lastname: Surma
authors.forename: Tomasz
authors.initials: T
authors.lastname: Sawczyn
authors.forename: Marek
authors.initials: M
authors.lastname: Hartleb
mesh_terms: D000328:Adult; D000368:Aged; D016207:Cytokines / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D058851:GPI-Linked Proteins / Q000032:analysis / Q000096:biosynthesis; D019698:Hepatitis C, Chronic / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D037102:Lectins / Q000032:analysis / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D055815:Young Adult
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins