title: Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China.
abstract: Hepatitis B virus (HBV) infection is a critical global health issue and moderately epidemic in Western China, but HBV molecular epidemiology characteristics are still limited. We conducted this study to investigate HBV genotypes and antiviral resistant mutations in this multi-ethnic area. A total of 1316 HBV patients were recruited from four ethnic groups from 2011 to 2013. Genotypes and resistant mutations were determined by Sanger sequencing. Four genotypes (B, C, D and C/D) were identified. Genotype B and C were common in Han population, while genotype D was predominant in Uygurs. Genotype C was the major genotype in both Tibetans and Yis, and recombinant C/D was found in Tibetans only. Lamivudine resistance was common in all populations, especially in Hans with prevalence of 42.8%. Entecavir resistance was barely observed regardless of ethnicity. Genotype C isolates had higher rates of rtA181T/V than genotype B (13.5% vs. 5.1%, P < 0.001), in accordance with higher prevalence of resistance to adefovir (20.0% vs. 9.5%, P < 0.001). While incidence of resistant mutations to other drugs and clinical factors showed no difference among different genotypes. HBV genotypes and resistance-conferring mutations had different geographic and demographic distributions in Western China, which provided molecular epidemiology data for clinical management.
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou district, Chengdu 610041, People's Republic of China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou district, Chengdu 610041, People's Republic of China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Liao
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou district, Chengdu 610041, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou district, Chengdu 610041, People's Republic of China.
authors.forename: Bei
authors.initials: B
authors.lastname: Cai
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou district, Chengdu 610041, People's Republic of China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Su
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou district, Chengdu 610041, People's Republic of China.
authors.forename: Binwu
authors.initials: B
authors.lastname: Ying
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou district, Chengdu 610041, People's Republic of China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou district, Chengdu 610041, People's Republic of China.
authors.forename: Chuanmin
authors.initials: C
authors.lastname: Tao
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou district, Chengdu 610041, People's Republic of China.
authors.forename: Lanlan
authors.initials: L
authors.lastname: Wang
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000235:genetics*; D024882:Drug Resistance, Viral / Q000235:genetics*; D005006:Ethnicity; D005260:Female; D005838:Genotype; D006147:Guanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006515:Hepatitis B virus / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000188:drug therapy / Q000453:epidemiology* / Q000208:ethnology / Q000821:virology; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D009154:Mutation; D063065:Organophosphonates / Q000627:therapeutic use; D015995:Prevalence
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D063065:Organophosphonates; D019259:Lamivudine; C413685:entecavir; D006147:Guanine; C053001:adefovir; D000225:Adenine