title: Androgen receptor gene polymorphism influence fat accumulation: A longitudinal study from adolescence to adult age.
abstract: To determine the influence of androgen receptor CAG and GGN repeat polymorphisms on fat mass and maximal fat oxidation (MFO), CAG and GGN repeat lengths were measured in 128 young boys, from which longitudinal data were obtained in 45 of them [mean ± SD: 12.8 ± 3.6 years old at recruitment, and 27.0 ± 4.8 years old at adult age]. Subjects were grouped as CAG short (CAGS) if harboring repeat lengths ≤  21, the rest as CAG long (CAGL); and GGN short (GGNS) if GGN repeat lengths ≤  23, or long if >  23 (GGNL). CAGSand GGNSwere associated with lower adiposity than CAGLor GGNL(P < 0.05). There was an association between the logarithm of CAG repeats polymorphism and the changes of body mass (r = 0.34, P = 0.03). At adult age, CAGSmen showed lower accumulation of total body and trunk fat mass, and lower resting metabolic rate (RMR) and MFO per kg of total lean mass compared with CAGL(P < 0.05). GGNSmen also showed lower percentage of body fat (P < 0.05). In summary, androgen receptor CAG and GGN repeat polymorphisms are associated with RMR, MFO, fat mass, and its regional distribution in healthy male adolescents, influencing fat accumulation from adolescence to adult age.
authors.affiliation: Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: J G
authors.initials: JG
authors.lastname: Ponce-González
authors.affiliation: Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Rodríguez-Garcia
authors.affiliation: Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Losa-Reyna
authors.affiliation: Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Guadalupe-Grau
authors.affiliation: Department of Biochemistry and Physiology, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Canary Islands Cancer Research Institute (ICIC), University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: F G
authors.initials: FG
authors.lastname: Rodriguez-Gonzalez
authors.affiliation: Department of Biochemistry and Physiology, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Canary Islands Cancer Research Institute (ICIC), University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: B N
authors.initials: BN
authors.lastname: Díaz-Chico
authors.affiliation: Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Dorado
authors.affiliation: Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Serrano-Sanchez
authors.affiliation: Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. lopezcalbet@gmail.com.|Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. lopezcalbet@gmail.com.
authors.forename: J A L
authors.initials: JA
authors.lastname: Calbet
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D001481:Basal Metabolism / Q000235:genetics*; D001823:Body Composition / Q000235:genetics; D050218:Body Fat Distribution; D002153:Calorimetry, Indirect; D002648:Child; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010084:Oxidation-Reduction; D010809:Physical Fitness; D011110:Polymorphism, Genetic; D011944:Receptors, Androgen / Q000235:genetics*; D055815:Young Adult
chemical_list: C410798:AR protein, human; D011944:Receptors, Androgen
keywords: AR CAG polymorphisms; AR GGN polymorphisms; adolescent; fat mass