title: Oral anticoagulation therapy and laser surgery for benign prostatic hyperplasia: stop, replace, or continue?
abstract: OBJECTIVE
  To update on the available literature that assessed laser surgery for benign prostatic obstruction (BPO) in patients under antithrombotic.
  
  
  RESULTS
  All types of laser might be suitable to decrease the bleeding risk in patients under antithrombotic. However, there is no consensus on the appropriate perioperative management of antithrombotic. Most of the studies mixed patients with coumarin derivatives or platelet aggregation inhibitors and did not discriminate the results according to the type of antithrombotic. The continuation of low-dose aspirin is feasible and might not increase bleeding risk during the perioperative period. Conversely, the literature is still too sparse and the protocols reported are too heterogeneous to provide any firm recommendation regarding the continuation, withdrawn, or bridging of clopidogrel and coumarin derivatives during laser procedures for BPO. The approach with new oral anticoagulants is even more uncertain as no data are available in this setting.
  
  
  CONCLUSIONS
  The decision to stop, continue, or replace antithrombotic should rely on both thrombotic and hemorrhagic risks. Therefore, urologist, cardiologist, and anesthesiologist should discuss altogether each case. Further studies are needed to provide a high level of evidence regarding the perioperative management of antithrombotic in the era of laser BPO procedures.
authors.affiliation: aUrology department, Limoges University Hospital bUrology department, University Hospital of Rennes, Rennes, France.
authors.forename: Aurelien
authors.initials: A
authors.lastname: Descazeaud
authors.forename: Romain
authors.initials: R
authors.lastname: Mathieu
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D057915:Drug Substitution; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects / Q000592:standards; D008297:Male; D019106:Postoperative Hemorrhage / Q000139:chemically induced; D017410:Practice Guidelines as Topic; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000601:surgery*; D018570:Risk Assessment; D012307:Risk Factors; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents