title: Extracellular matrix for repair of type IV laryngotracheo-esophageal cleft.
abstract: Type IV laryngotracheo-esophageal cleft (LTEC) extending to the level of the carina presents unique challenges to operative repair, particularly with respect to soft tissue durability. This is the first report of CorMatrix(®) extra-cellular matrix (ECM) material use as an interposition graft in a four-layered LTEC repair. At day seven post-operatively, there was epithelialization along the surface of the trachea. At 3 months, she was stable for tracheotomy. At 6 months, the posterior wall resembled completely native tissue. CorMatrix(®) ECM(®) use intra-operatively and post-operative outcome were both highly satisfactory. No adverse reaction was seen in this case through 12-month follow up.
authors.affiliation: Pediatric Otolaryngology - Head & Neck Surgery, Wake Forest(®) School of Medicine, WFUBMC-OHNS, Medical Center Blvd., Winston-Salem, NC 27157, United States. Electronic address: akevans@wakehealth.edu.
authors.forename: Adele K
authors.initials: AK
authors.lastname: Evans
authors.affiliation: Cardiothoracic Surgery, Wake Forest(®) School of Medicine, WFUBMC-CT, Medical Center Blvd., Winston-Salem, NC 27157, United States. Electronic address: nkon@wakehealth.edu.
authors.forename: Neal D
authors.initials: ND
authors.lastname: Kon
mesh_terms: D000015:Abnormalities, Multiple / Q000601:surgery*; D000013:Congenital Abnormalities / Q000601:surgery*; D004947:Esophagus / Q000002:abnormalities / Q000601:surgery*; D005109:Extracellular Matrix; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007830:Larynx / Q000002:abnormalities* / Q000601:surgery; D014132:Trachea / Q000002:abnormalities / Q000601:surgery*; D014140:Tracheotomy
keywords: Airway reconstruction; Extra-cellular matrix; Laryngotracheo-esophageal cleft; Tracheo-esophageal septum