title: Asymmetric Allylic Alkylation of β-Ketoesters with Allylic Alcohols by a Nickel/Diphosphine Catalyst.
abstract: Asymmetric allylic alkylation of β-ketoesters with allylic alcohols catalyzed by [Ni(cod)2]/(S)-H8-BINAP was found to be a superior synthetic protocol for constructing quaternary chiral centers at the α-position of β-ketoesters. The reaction proceeded in high yield and with high enantioselectivity using various β-ketoesters and allylic alcohols, without any additional activators. The versatility of this methodology for accessing useful and enantioenriched products was demonstrated.
authors.affiliation: Department of Chemistry, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kita
authors.affiliation: Department of Chemistry, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan.
authors.forename: Rahul D
authors.initials: RD
authors.lastname: Kavthe
authors.affiliation: Department of Chemistry, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Oda
authors.affiliation: Department of Chemistry, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan. mashima@chem.es.osaka-u.ac.jp.
authors.forename: Kazushi
authors.initials: K
authors.lastname: Mashima
keywords: alkylation; allylic compounds; asymmetric catalysis; enantioselectivity; nickel