title: DOWN'S SYNDROME WITH NEONATAL ALLOIMMUNE THROMBOCYTOPENIA DUE TO HLA-A2 ANTIBODY.
abstract: Anti-HLA antibodies reportedly exist in the one third of pregnant women. But few occurrences of neonatal alloimmune thrombocytopenia (NAIT) caused by anti-HLA antibodies have been reported. Here a male baby, who was admitted for low birth weight with Down syndrome (DS), was suffered from thrombocytopenia without transient myeloproliferative disorder (TMD). Positive reactions of HLA-specific antibodies were detected in maternal serum. Cross-matching tests between maternal serum and paternal platelets and lymphocytes were strongly positive. It is most conceivable that the previous pregnancy of the mother induced the production of anti-HLA-A2 antibody, which crossed the placenta and subsequently caused an NAIT in the case presented. This is the first case of DS with NAIT due to anti-HLA antibodies.
authors.affiliation: Department of Neonatology, Japanese Red Cross Musashino Hospital.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Nakamura
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Nomura
authors.forename: Takashi
authors.initials: T
authors.lastname: Kamohara
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Takahashi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hatanaka
authors.forename: Michiko
authors.initials: M
authors.lastname: Kusakari
authors.forename: Mari
authors.initials: M
authors.lastname: Nakamura
authors.forename: Kinuyo
authors.initials: K
authors.lastname: Kawabata
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohto
mesh_terms: D004314:Down Syndrome / Q000150:complications*; D015789:HLA-A2 Antigen / Q000276:immunology*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000276:immunology
chemical_list: D015789:HLA-A2 Antigen