title: Successful treatment of cytomegalovirus enteritis after unrelated allogeneic stem cell transplantation by the infusion of ex vivo-expanded CD4+ lymphocytes derived from the recipient's peripheral blood donor cells.
abstract: Adoptive immunotherapies have been developed for antiviral agent-refractory cytomegalovirus (CMV) disease after stem cell transplantation (SCT). However, the application of such strategies is limited, particularly in terms of need for donor cooperation regarding blood sampling and inaccessibility in the setting of cord blood transplantation. Herein, we describe the first successful treatment of antiviral agent-refractory CMV enteritis after allogeneic SCT by the infusion of ex vivo-expanded donor-derived CD4(+) lymphocytes obtained from the recipient's peripheral blood.
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Muto
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takeda
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tsukamoto
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.|Department of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Chiba, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sakai
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.|Department of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Chiba, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Mimura
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Ohwada
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takeuchi
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Sakaida
authors.affiliation: Department of Pathology, Chiba University Hospital, Chiba, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ota
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.|Department of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Chiba, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Iseki
authors.affiliation: Department of Virology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Shimizu
authors.affiliation: Department of Pediatrics and Developmental Biology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Morio
authors.affiliation: Department of Hematology, Chiba University Hospital, Chiba, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Nakaseko
mesh_terms: D001782:Blood Donors; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D003587:Cytomegalovirus / Q000302:isolation & purification* / Q000502:physiology; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000473:pathology / Q000821:virology*; D004751:Enteritis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous / Q000009:adverse effects; D014775:Virus Activation
keywords: CD4+ lymphocyte; allogeneic stem cell transplantation; cytomegalovirus enteritis; donor lymphocyte infusion