title: New α-glucosidase inhibiting anthracenone from the barks of Harungana madagascariensis Lam.
abstract: Two new 10-hydroxy-9(10H)-anthracenone, madagascenone A (1) and B (2), were isolated from the barks of Harungana madagascariensis Lam. The structures of the compounds were determined using 1D- and 2D-NMR and mass spectroscopic techniques. Both of the compounds showed an in vitro α-glucosidase inhibition with IC50= 69.9 ± 4.21 and 122.3 ± 1.13 μM, respectively, more potent than the standard acarbose (IC50= 840 ± 1.23 μM).
authors.affiliation: a Department of Microbiology , Olabisi Onabanjo University , Ago-Iwoye , Nigeria.|b H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences , University of Karachi , Karachi , Pakistan.
authors.forename: Ismail B
authors.initials: IB
authors.lastname: Onajobi
authors.affiliation: b H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences , University of Karachi , Karachi , Pakistan.
authors.forename: Achyut
authors.initials: A
authors.lastname: Adhikari
authors.affiliation: b H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences , University of Karachi , Karachi , Pakistan.
authors.forename: Shabbir
authors.initials: S
authors.lastname: Hussain
authors.affiliation: b H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences , University of Karachi , Karachi , Pakistan.
authors.forename: Kulsoom
authors.initials: K
authors.lastname: Javaid
authors.affiliation: c Environmental and Biotechnology Unit, Department of Microbiology , University of Ibadan , Ibadan , Nigeria.
authors.forename: Obasola E
authors.initials: OE
authors.lastname: Fagade
authors.affiliation: d Department of Chemistry , University of Ibadan , Ibadan , Nigeria.
authors.forename: I A
authors.initials: IA
authors.lastname: Oladosu
keywords: Harungana madagascariensis;  madagascenone A and B; α-glucosidase inhibition