title: Complete response after chemotherapy and radiotherapy of a tonsillar histiocytic sarcoma with regional lymph node involvement: a case report and review of the literature.
abstract: We describe a case of tonsillar histiocytic sarcoma (HS) with regional lymph node involvement and complete response after multi-disciplinary therapy. Immunohistochemistry showed strong positive tumor staining for CD 68, and negative staining for CD20, CD45R0 and CD30 and non-cohesive proliferation of neoplastic histiocytes. Systemic chemotherapy with cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide (CHOP-E) chemotherapy followed by radiotherapy was delivered to the patient. No evidence of recurrent disease existed on regular follow up three years later. The diagnostic methods and the practical treatment solutions are discussed here. We believe that although HS has been regarded as a potentially fatal disease entity, there remain some cases that do not pursue such an aggressive clinical course.
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer Center Shanghai 200032, China ; Department of Oncology, Shanghai Medical College of Fudan University Shanghai 200032, China.
authors.forename: Xingxing
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer Center Shanghai 200032, China ; Department of Oncology, Shanghai Medical College of Fudan University Shanghai 200032, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Fudan University Shanghai Cancer Center Shanghai 200032, China ; Department of Oncology, Shanghai Medical College of Fudan University Shanghai 200032, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Imaging, Fudan University Shanghai Cancer Center Shanghai 200032, China ; Department of Oncology, Shanghai Medical College of Fudan University Shanghai 200032, China.
authors.forename: Yajia
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Department of Radiation Oncology, National Cancer Centre Singapore Singapore.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Tuan
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer Center Shanghai 200032, China ; Department of Oncology, Shanghai Medical College of Fudan University Shanghai 200032, China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Medical Oncology, Fudan University Shanghai Cancer Center Shanghai 200032, China ; Department of Oncology, Shanghai Medical College of Fudan University Shanghai 200032, China.
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Hong
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer Center Shanghai 200032, China ; Department of Oncology, Shanghai Medical College of Fudan University Shanghai 200032, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer Center Shanghai 200032, China ; Department of Oncology, Shanghai Medical College of Fudan University Shanghai 200032, China.
authors.forename: Xiaomao
authors.initials: X
authors.lastname: Guo
keywords: Histiocytic sarcoma; chemotherapy; radiotherapy; survival outcome; tonsillar