title: Chronic Lymphocytic Leukemia and Other Lymphoproliferative Disorders.
abstract: Chronic lymphocytic leukemia affects less than 1% of US adults but is the most common leukemia and primarily affects older patients. Non-Hodgkin lymphomas are the seventh most common cancers in the United States and also primarily affect older patients. In general, older patients should be treated differently than their younger, fitter counterparts. Fitness level and comorbidities should be taken into account when planning treatment. First-line treatment of most of these B-cell lymphoproliferative disorders consists of chemoimmunotherapy. In relapsed and refractory disease, there is a growing role for therapies targeting the B-cell receptor signaling pathway.
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 445A Wiseman Hall, 410 West 12th Avenue, Columbus, OH 43210, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Wall
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 445A Wiseman Hall, 410 West 12th Avenue, Columbus, OH 43210, USA. Electronic address: Jennifer.Woyach@osumc.edu.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Woyach
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D019468:Disease Management; D019317:Evidence-Based Medicine; D015577:Geriatric Assessment; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000628:therapy*; D008232:Lymphoproliferative Disorders / Q000628:therapy*; D012307:Risk Factors; D012944:Social Support
keywords: Chronic lymphocytic leukemia; Elderly; Non-Hodgkin lymphoma