title: Work and leisure time sitting and inactivity: Effects on cardiorespiratory and metabolic health.
abstract: Prospective relationships between sedentary behaviour and cardiorespiratory and metabolic markers need to be better delineated in adults with different physical activity levels. We examined the separate and combined relationships of work and leisure time sitting and moderate to vigorous physical activity (MVPA) with cardiorespiratory fitness and cardiometabolic risk factors.
  
  
  
  A total of 2308 adults from the Health2006 cohort were followed for five years. Work sitting, leisure time sitting and MVPA were self-reported and cardiorespiratory fitness (Vo2max) was estimated by a submaximal step test. Cardiometabolic risk factors included body mass index, waist circumference, systolic and diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol and insulin levels. Prospective associations with each sitting domain alone and in combination with MVPA level were investigated by multiple linear regression analyses, as were the reverse associations with weight status (body mass index and waist circumference).
  
  
  
  Baseline leisure time sitting predicted increased insulin (p < 0.05) and decreased estimated Vo2max (p < 0.05), whereas work sitting predicted decreased waist circumference (p < 0.05) and increased estimated Vo2max (p < 0.01) over the five-year study. Low baseline leisure time sitting, but not work sitting, predicted increased estimated Vo2max regardless of the MVPA level. Weight status predicted increased leisure time sitting (p < 0.01), but leisure time sitting did not predict weight.
  
  
  
  These findings emphasize sedentary behaviour during leisure time, rather than at work, as a risk behaviour in relation to cardiorespiratory and metabolic health. For cardiorespiratory fitness, it may be important not only to promote MVPA, but also to discourage sedentary behaviour during leisure time.
authors.affiliation: Research Centre for Prevention and Health, Glostrup - Rigshospitalet, Denmark madina.saidj@regionh.dk.
authors.forename: Madina
authors.initials: M
authors.lastname: Saidj
authors.affiliation: Research Centre for Prevention and Health, Glostrup - Rigshospitalet, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Faculty of Medicine, University of Aalborg, Denmark.
authors.forename: Torben
authors.initials: T
authors.lastname: Jørgensen
authors.affiliation: Research Centre for Prevention and Health, Glostrup - Rigshospitalet, Denmark.
authors.forename: Rikke Kart
authors.initials: RK
authors.lastname: Jacobsen
authors.affiliation: Research Centre for Prevention and Health, Glostrup - Rigshospitalet, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Department of Clinical Experimental Research, Glostrup - Rigshospitalet, Denmark.
authors.forename: Allan
authors.initials: A
authors.lastname: Linneberg
authors.affiliation: Université Pierre et Marie Curie-Paris 6, Department of Nutrition Pitié-Salpêtrière Hospital, Centre for Research on Human Nutrition Ile-de-France, Institute of Cardiometabolism and Nutrition, Paris, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Oppert
authors.affiliation: Research Centre for Prevention and Health, Glostrup - Rigshospitalet, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
authors.forename: Mette
authors.initials: M
authors.lastname: Aadahl
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D004734:Energy Metabolism; D005080:Exercise Test; D005260:Female; D006801:Humans; D007899:Leisure Activities; D008055:Lipids; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D057185:Sedentary Behavior; D057566:Self Report; D055815:Young Adult
chemical_list: D008055:Lipids
keywords: Sedentary behaviour; adults; physical activity; prospective study