title: Modifying influence of occupational inflammatory diseases on the level of chromosome aberrations in coal miners.
abstract: Coal miners are exposed to a wide range of genotoxic agents that can induce genome damage. In addition, miners are characterised by a high risk of the initiation of different occupational inflammatory as well as non-inflammatory diseases. The aim of this investigation is to analyse the modifying influence of occupational pulmonary inflammatory diseases on the level of chromosome aberrations (CAs) in miners working in underground coal mines in Kemerovo Region (Russian Federation). The study group included 90 coal miners with the following pulmonary diseases: chronic dust-induced bronchitis (CDB) and coal-workers' pneumoconiosis (CWP) (mean age = 53.52±2.95 years; mean work experience in coal-mining conditions = 27.70±3.61 years). As a population control (control 1), we have used venous blood extracted from 124 healthy unexposed men. The mean age in this group was 50.92±4.56 years. Control 2 was the venous blood extracted from 42 healthy coal miners (mean age = 51.56±6.38 years; mean work experience in coal-mining conditions = 25.43±8.14 years). We have discovered that coal miners are characterised by an increased general level of CAs as well as an increased frequency of several types of CAs. The significant increase in the frequency of aberration per 100 cells and aberration of chromosome type was discovered in the group of pulmonary disease patients (study group). No correlations of the level of chromosome damage with age, smoking status and work experience in coal-mining conditions were discovered.
authors.affiliation: Biology Faculty, Department of Genetics, Kemerovo State University, Krasnaya St 6, 650043 Kemerovo, Russian Federation, kitsuneoni42@gmail.com.
authors.forename: Valentin P
authors.initials: VP
authors.lastname: Volobaev
authors.affiliation: Biology Faculty, Department of Genetics, Kemerovo State University, Krasnaya St 6, 650043 Kemerovo, Russian Federation, Institute of Human Ecology of SB RAS, Laboratory of Cytogenetics, Leningradsky Ave 10, 650065 Kemerovo, Russian Federation and.
authors.forename: Maxim Yu
authors.initials: MY
authors.lastname: Sinitsky
authors.affiliation: Biology Faculty, Department of Genetics, Kemerovo State University, Krasnaya St 6, 650043 Kemerovo, Russian Federation.
authors.forename: Aleksey V
authors.initials: AV
authors.lastname: Larionov
authors.affiliation: Biology Faculty, Department of Genetics, Kemerovo State University, Krasnaya St 6, 650043 Kemerovo, Russian Federation, Institute of Human Ecology of SB RAS, Laboratory of Cytogenetics, Leningradsky Ave 10, 650065 Kemerovo, Russian Federation and.
authors.forename: Vladimir G
authors.initials: VG
authors.lastname: Druzhinin
authors.affiliation: Research Institute for Complex Problems of Hygiene and Occupational Diseases, Laboratory of Population Genetics, Kutuzova St 23, 654041 Novokuznetsk, Russian Federation.
authors.forename: Nikolay I
authors.initials: NI
authors.lastname: Gafarov
authors.affiliation: Biology Faculty, Department of Genetics, Kemerovo State University, Krasnaya St 6, 650043 Kemerovo, Russian Federation, Institute of Human Ecology of SB RAS, Laboratory of Cytogenetics, Leningradsky Ave 10, 650065 Kemerovo, Russian Federation and.
authors.forename: Varvara I
authors.initials: VI
authors.lastname: Minina
authors.affiliation: Institute of Human Ecology of SB RAS, Laboratory of Cytogenetics, Leningradsky Ave 10, 650065 Kemerovo, Russian Federation and.
authors.forename: Jury E
authors.initials: JE
authors.lastname: Kulemin
mesh_terms: D002869:Chromosome Aberrations; D003032:Coal Mining; D005260:Female; D006801:Humans; D007249:Inflammation / Q000453:epidemiology / Q000235:genetics*; D008171:Lung Diseases / Q000209:etiology; D008297:Male; D008875:Middle Aged; D000067572:Miners; D009784:Occupational Diseases / Q000453:epidemiology / Q000235:genetics*; D016273:Occupational Exposure; D012307:Risk Factors