title: A DPOAE assessment of outer hair cell integrity in ears with age-related hearing loss.
abstract: Distortion product otoacoustic emissions (DPOAEs) were used to assess outer hair cell (OHC) integrity in human ears with age-related hearing loss. Sound pressure measurements were made in the ear canal over the stimulus range 40-90 dB SPL (L2), with L1 = 0.45*L2 + 44 with F2 = 2 and 3 or 4 kHz. Model-generated DPOAE I/O functions were fit to DPOAE data to quantify the contribution of loss of nonlinearity (OHC loss) to the hearing loss. Results suggest OHC loss as a contributing cause of age-related hearing, regardless of audiogram configuration. It seems likely that OHC and strial pathology co-exist in ears with AHL.
authors.affiliation: Graduate School of Systemic Neurosciences, Ludwig-Maximilians University, Munich, Germany. Electronic address: margarete.ueberfuhr@posteo.de.
authors.forename: Margarete A
authors.initials: MA
authors.lastname: Ueberfuhr
authors.affiliation: Audiology and Aural Rehabilitation, University of Minnesota Medical Center, Minneapolis, MN, 55455, USA. Electronic address: hfehlber@umail.iu.edu.
authors.forename: Hannah
authors.initials: H
authors.lastname: Fehlberg
authors.affiliation: Department of Communication Sciences and Disorders, University of Iowa, Iowa City, IA, 52242, USA. Electronic address: shawn-goodman@uiowa.edu.
authors.forename: Shawn S
authors.initials: SS
authors.lastname: Goodman
authors.affiliation: Department of Speech and Hearing Sciences, Indiana University, Bloomington, IN, 47405, USA. Electronic address: rwithnel@indiana.edu.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Withnell
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold; D016022:Case-Control Studies; D005260:Female; D018072:Hair Cells, Auditory, Outer / Q000473:pathology*; D006309:Hearing; D006801:Humans; D008297:Male; D040542:Mechanotransduction, Cellular; D008875:Middle Aged; D017711:Nonlinear Dynamics; D017084:Otoacoustic Emissions, Spontaneous; D011304:Presbycusis / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D011312:Pressure; D013016:Sound; D055815:Young Adult
keywords: Model; Otoacoustic emission; Presbycusis