title: Endocrinologic Aspects of Hidradenitis Suppurativa.
abstract: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder of unknown etiology. The role of hormones in HS remains unclear, but the observation of premenstrual flares, female predominance, and improvement during pregnancy suggest a hormonal/metabolic background. The reported positive effects of antiandrogen therapy supports a possible role of androgens. The predominant onset of the disease years after puberty may indicate a metabolic disorder. Obesity contributes significantly to HS pathogenesis; diabetes, dyslipidemia, the metabolic syndrome, and polycystic ovarian syndrome are among the commonest comorbidities. More studies are required to clarify a potential hormonal dysregulation in HS.
authors.affiliation: Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Karagiannidis
authors.affiliation: Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany.
authors.forename: Georgios
authors.initials: G
authors.lastname: Nikolakis
authors.affiliation: Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany. Electronic address: christos.zouboulis@klinikum-dessau.de.
authors.forename: Christos C
authors.initials: CC
authors.lastname: Zouboulis
mesh_terms: D000726:Androgen Antagonists / Q000627:therapeutic use; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000378:metabolism; D050171:Dyslipidemias / Q000453:epidemiology / Q000378:metabolism; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D017497:Hidradenitis Suppurativa / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000378:metabolism; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology / Q000378:metabolism
chemical_list: D000726:Androgen Antagonists; D012739:Gonadal Steroid Hormones
keywords: Acne inversa; Androgens; Apocrine glands; Endocrinology; Hidradenitis suppurativa; Hyperandrogenism; Metabolic syndrome; Obesity