title: Serotonin 7 Receptor Variants Are Not Associated with Response to Second-Generation Antipsychotics in Japanese Schizophrenia Patients.
abstract: BACKGROUND
  Individual differences in serotonin 7 receptor (5-HT7R) may result in variable response to antipsychotics with 5-HT7R antagonism. This study investigated the relationship between single nucleotide polymorphisms (SNPs) in the 5-HT7R gene (HTR7) and the efficacy of second-generation antipsychotic drugs with a high affinity for this receptor in Japanese schizophrenia.
  
  
  METHODS
  Perospirone or aripiprazole was administered to 100 patients with schizophrenia in a randomized controlled study. All patients were genotyped for three candidate SNPs (rs12412496, rs7916403, and rs1935349). Patient improvement on the Positive and Negative Syndrome Scale (PANSS) total score at 12 weeks was assessed as the primary outcome. PANSS 5-factor scores were investigated as the secondary outcome.
  
  
  RESULTS
  Improvement on the PANSS total score and genetic polymorphisms showed no correlation. The rs12412496-rs7916403-rs1935349 A-T-A haplotype was correlated with worse improvement in the cognition score (haplotype frequency: 0.285, p = 0.046, permuted p = 0.043).
  
  
  CONCLUSIONS
  Our results show that HTR7 variants are not related to the overall improvement in schizophrenia symptoms.
authors.affiliation: Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Takekita
authors.forename: Chiara
authors.initials: C
authors.lastname: Fabbri
authors.forename: Masaki
authors.initials: M
authors.lastname: Kato
authors.forename: Shinpei
authors.initials: S
authors.lastname: Nonen
authors.forename: Shiho
authors.initials: S
authors.lastname: Sakai
authors.forename: Naotaka
authors.initials: N
authors.lastname: Sunada
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Koshikawa
authors.forename: Masataka
authors.initials: M
authors.lastname: Wakeno
authors.forename: Gaku
authors.initials: G
authors.lastname: Okugawa
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D000068180:Aripiprazole / Q000627:therapeutic use*; D044466:Asian People; D005260:Female; D006801:Humans; D054833:Isoindoles / Q000627:therapeutic use*; D007564:Japan; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D057285:Precision Medicine; D011569:Psychiatric Status Rating Scales; D011985:Receptors, Serotonin / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics*; D013844:Thiazoles / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D054833:Isoindoles; D011985:Receptors, Serotonin; D013844:Thiazoles; C104425:serotonin 7 receptor; D000068180:Aripiprazole; C065533:perospirone