title: Metabolic vulnerability of KRAS-driven cancer cells.
abstract: Interfering with anaplerotic utilization of glutamine (Gln) was recently reported to sensitize KRAS-driven cancer cells to the cytotoxic effects of capecitabine and paclitaxel. This effect was due to bypass of a Gln-dependent G1cell cycle checkpoint in these cells. This study highlights therapeutic opportunities created by metabolic reprogramming in cancer cells.
authors.affiliation: Department of Biological Sciences; Hunter College of the City University of New York; New York, NY USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Foster
keywords: Glutamine; KRAS; TCA cycle; anaplerosis; cell cycle