title: Hemostatic, inflammatory, and oxidative markers in pesticide user farmers.
abstract: The aim of this work was to investigate inflammatory, oxidative, and thrombotic parameters as biomarkers in farmers exposed to pesticides. Fifty farmers using chemical pesticides and 60 unexposed control men participated in this study. The Mediterranean diet compliance, the duration of pesticide use, and personal protection for pesticides handling were recorded using self-administered questionnaires. Serum biochemical parameters, oxidant/antioxidant, inflammatory, and thrombosis markers were determined. Our findings showed oxidative stress reflected by an increase in malondialdehyde, carbonyl proteins and superoxide anion levels and a decrease in vitamins C and E, glutathione, catalase, and superoxide dismutase activities in farmers. Serum C-reactive protein, prothrombin, and fibrinogen levels were enhanced in these farmers. In conclusion, inflammation, oxidative stress, and metabolic perturbations reflected the possibility of the effects of pesticides to farmers.
authors.affiliation: a Laboratory of Physiology and Biochemistry of Nutrition , Department of Biology, Faculty of Sciences, University Abou-Bekr Belkaïd , Tlemcen , Algeria .
authors.forename: Fatima Zohra
authors.initials: FZ
authors.lastname: Madani
authors.affiliation: a Laboratory of Physiology and Biochemistry of Nutrition , Department of Biology, Faculty of Sciences, University Abou-Bekr Belkaïd , Tlemcen , Algeria .
authors.forename: Merzouk
authors.initials: M
authors.lastname: Hafida
authors.affiliation: b Department of Technical Sciences , Faculty of Engineering, University Abou-Bekr Belkaïd , Tlemcen , Algeria .
authors.forename: Sid Ahmed
authors.initials: SA
authors.lastname: Merzouk
authors.affiliation: a Laboratory of Physiology and Biochemistry of Nutrition , Department of Biology, Faculty of Sciences, University Abou-Bekr Belkaïd , Tlemcen , Algeria .
authors.forename: Bouchra
authors.initials: B
authors.lastname: Loukidi
authors.affiliation: c Department of Hemobiology , Tlemcen Hospital , Tlemcen , Algeria , and.
authors.forename: Katia
authors.initials: K
authors.lastname: Taouli
authors.affiliation: d INSERM UMR 866, ''Lipids Nutrition Cancer'', University of Burgundy, Faculty of Sciences , Dijon , France.
authors.forename: Michel
authors.initials: M
authors.lastname: Narce
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D002374:Catalase / Q000097:blood; D000067565:Farmers; D005340:Fibrinogen / Q000378:metabolism; D005978:Glutathione / Q000097:blood; D006490:Hemostatics / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000209:etiology; D016015:Logistic Models; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis*; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D010575:Pesticides / Q000506:poisoning*; D050050:Protein Carbonylation; D011516:Prothrombin / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood; D013481:Superoxides / Q000097:blood; D011795:Surveys and Questionnaires; D014810:Vitamin E / Q000097:blood
chemical_list: D015415:Biomarkers; D006490:Hemostatics; D010575:Pesticides; D013481:Superoxides; D014810:Vitamin E; D008315:Malondialdehyde; D011516:Prothrombin; D005340:Fibrinogen; D002097:C-Reactive Protein; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D001205:Ascorbic Acid
keywords: Farmers; inflammation; oxidative stress; pesticide; thrombosis