title: The potential role of tissue-engineered urethral substitution: clinical and preclinical studies.
abstract: Urethral strictures and anomalies remain among the difficult problems in urology, with urethroplasty procedures being the most effective treatment options. The two major types of urethroplasty are anastomotic urethroplasty and widening the urethral lumen using flaps or grafts (i.e. substitution urethroplasty). However, no ideal material for the latter has been found so far. Designing and selecting such a material is a necessary and challenging endeavour, driving the need for further bioengineered urethral tissue research. This article reviews currently available studies on the potentialities of tissue engineering in urethral reconstruction, in particular those describing the use of both acellular and recellularized tissue-engineered constructs in animal and human models. Possible future developments in this field are also discussed. Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: Wake Forest School of Medicine, Winston-Salem, NC, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Atala
authors.affiliation: Research Institute of Uronephrology and Reproductive Health, I. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Danilevskiy
authors.affiliation: Research Institute of Molecular Medicine, I. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
authors.forename: Alexey
authors.initials: A
authors.lastname: Lyundup
authors.affiliation: I. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
authors.forename: Petr
authors.initials: P
authors.lastname: Glybochko
authors.affiliation: Research Institute of Uronephrology and Reproductive Health, I. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
authors.forename: Denis
authors.identifier: 0000-0003-2173-0566
authors.initials: D
authors.lastname: Butnaru
authors.affiliation: Research Institute of Uronephrology and Reproductive Health, I. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
authors.forename: Andrey
authors.initials: A
authors.lastname: Vinarov
authors.affiliation: Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston-Salem, NC, USA.
authors.forename: James J
authors.initials: JJ
authors.lastname: Yoo
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001698:Biomedical Engineering; D006801:Humans; D011108:Polymers / Q000737:chemistry; D019651:Plastic Surgery Procedures / Q000379:methods; D044968:Regenerative Medicine / Q000379:methods; D013524:Surgical Flaps; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D019737:Transplants; D016896:Treatment Outcome; D014521:Urethra / Q000502:physiology* / Q000601:surgery*; D014525:Urethral Stricture / Q000601:surgery*; D013520:Urologic Surgical Procedures / Q000379:methods*
chemical_list: D011108:Polymers
keywords: matrices; regenerative medicine; scaffolds; tissue engineering; tissue-engineered constructs; urethral strictures; urethroplasty