title: Scutellaria radix Extract as a Natural UV Protectant for Human Skin.
abstract: Ultraviolet (UV) radiation induces oxidative injury and inflammation in human skin. Scutellaria radix (SR, the root of Scutellaria baicalensis Georgi) contains flavonoids with high UV absorptivity and antioxidant properties. The purpose of this study was to examine the potential use of SR extract as an additive in cosmetic products for UV protection. SR extract and its butanol (BuOH) fraction strongly absorbed UV radiation and displayed free radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl radials and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radicals. They also attenuated the UV-induced death of HaCaT cells. Sunscreen creams, with or without supplementation of SR extract BuOH fraction, were tested in vivo in human trials to evaluate potential skin irritation and determine the sun protection factor (SPF). Both sunscreen creams induced no skin irritation. A sunscreen cream containing 24% ZnO showed an SPF value of 17.8, and it increased to 22.7 when supplemented with 5% SR extract BuOH fraction. This study suggests that SR-derived materials are useful as safe cosmetic additives that provide UV protection.
authors.affiliation: Department of Molecular Medicine, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, 680, Gukchaebosang-ro, Jung-gu, Daegu, 41944, Korea.
authors.forename: Jin Kyung
authors.initials: JK
authors.lastname: Seok
authors.affiliation: Department of Molecular Medicine, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, 680, Gukchaebosang-ro, Jung-gu, Daegu, 41944, Korea.
authors.forename: Jun Yup
authors.initials: JY
authors.lastname: Kwak
authors.affiliation: Dermapro Skin Research Center, Dermapro Ltd., 30, Bangbaejungang-ro, Seocho-gu, Seoul, 06684, Korea.
authors.forename: Go Woon
authors.initials: GW
authors.lastname: Choi
authors.affiliation: Dermapro Skin Research Center, Dermapro Ltd., 30, Bangbaejungang-ro, Seocho-gu, Seoul, 06684, Korea.
authors.forename: Sang Mi
authors.initials: SM
authors.lastname: An
authors.affiliation: Department of Cosmeceutical Science, Daegu Hanny University, Gyeongsan, 38578, Korea.
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Kwak
authors.affiliation: Ruby Crown Co., Ltd., Kyungpook National University Business Incubation Center, 80, Daehak-ro, Buk-gu, Daegu, 41566, Korea.
authors.forename: Hyeong-Ho
authors.initials: HH
authors.lastname: Seo
authors.affiliation: Gyeongbuk Natural Color Industry Institute, 181, Cheonmun-ro, Yeongcheon-si, Gyeongsangbuk-do,, 38896, Korea.
authors.forename: Hwa-Jin
authors.initials: HJ
authors.lastname: Suh
authors.affiliation: Department of Molecular Medicine, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, 680, Gukchaebosang-ro, Jung-gu, Daegu, 41944, Korea.|Ruby Crown Co., Ltd., Kyungpook National University Business Incubation Center, 80, Daehak-ro, Buk-gu, Daegu, 41566, Korea.
authors.forename: Yong Chool
authors.initials: YC
authors.lastname: Boo
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D003358:Cosmetics; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D010851:Picrates / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D031364:Scutellaria baicalensis / Q000737:chemistry*; D012867:Skin / Q000187:drug effects*; D059405:Sun Protection Factor; D013473:Sunscreening Agents / Q000494:pharmacology*; D014466:Ultraviolet Rays
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D003358:Cosmetics; D005419:Flavonoids; D010851:Picrates; D010936:Plant Extracts; C499814:Scutellaria baicalensis extract; D013473:Sunscreening Agents; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Scutellaria baicalensis Georgi; human skin; oxidative stress; sun protection factor; ultraviolet