title: Correlation between body mass index and clinicopathological features of papillary thyroid microcarcinoma.
abstract: OBJECTIVE
  To demonstrate the relationships between body mass index (BMI) and the clinicopathological features of papillary thyroid microcarcinoma (PTMC) and papillary thyroid carcinoma (PTC).
  
  
  METHODS
  A total of 810 consecutive patients with PTC (501 patients with PTMC) who underwent total thyroidectomy in 2009-2013 were retrospectively reviewed. Height and weight were used to calculate BMI.
  
  
  RESULTS
  Increased BMI was strongly associated with i) extrathyroidal invasion (P < 0.001) and advanced TNM stage (P = 0.005) in patients with PTMC (n = 501), and ii) extrathyroidal invasion (P = 0.001), advanced TNM stage (P = 0.001), and multifocality (P = 0.002) in patients with PTC (n = 810). As compared with normal-weight patients with PTMC, obese patients with PTMC had greater risks of extrathyroidal invasion (OR = 5.214, P = 0.0270), and overweight patients with PTMC had greater risks of extrathyroidal invasion (OR = 2.165, P = 0.0013) and advanced TNM stage (OR = 2.019, P = 0.0137). As compared with normal-weight patients with PTC, obese patients with PTC had greater risks of extrathyroidal invasion (OR = 3.101, P = 0.0172), and overweight patients with PTC had greater risks of extrathyroidal invasion (OR = 1.486, P = 0.0279), advanced TNM stage (OR = 1.650, P = 0.0347), and multifocality (OR = 1.651, P = 0.0054).
  
  
  CONCLUSIONS
  Increased BMI might elevate the risks of aggressive clinicopathological features, such as extrathyroidal invasion and advanced TNM stage. Obesity control may play an important role in preventing the development of aggressive PTMCs and all PTCs.
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Zeming
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Yusufu
authors.initials: Y
authors.lastname: Maimaiti
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Yu
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Yiquan
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zeng
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Haiping
authors.initials: H
authors.lastname: Song
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Chong
authors.initials: C
authors.lastname: Lu
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Xin
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ming
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Chunping
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Xueqin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Xiu
authors.initials: X
authors.lastname: Nie
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
keywords: Body mass index; prognosis; thyroid papillary microcarcinoma