title: Pregnancy associated thrombotic thrombocytopenic purpura: Practical issues for patient management.
abstract: Thrombotic thrombocytopenic purpura (TTP) is a severe, life-threatening disease that needs urgent diagnosis and prompt therapeutic intervention. In pregnant women TTP may complicate the course of gestation putting mother and child at vital risk. Differential diagnosis with other obstetric and medical disorders may be difficult due to the overlap of several clinical and laboratory findings. Our understanding of the pathophysiology of TTP has allowed ADAMTS13 testing to have a central role in confirming the clinical diagnosis but the main limitation is that an ADAMTS13 assay is not available in "real time". Here we report the clinical course and treatment outcome of two young women with clinical manifestations of pregnancy associated TTP and briefly discuss the main topics of disease diagnosis and management.
authors.affiliation: Therapeutic Apheresis Unit and Stem Cell Manipulation Laboratory, Department of Transfusion Medicine, Azienda Ospedaliero Universitaria, Udine, Italy. Electronic address: chiara.savignano@aoud.sanita.fvg.it.
authors.forename: Chiara
authors.initials: C
authors.lastname: Savignano
authors.affiliation: Therapeutic Apheresis Unit and Stem Cell Manipulation Laboratory, Department of Transfusion Medicine, Azienda Ospedaliero Universitaria, Udine, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Rinaldi
authors.affiliation: Therapeutic Apheresis Unit and Stem Cell Manipulation Laboratory, Department of Transfusion Medicine, Azienda Ospedaliero Universitaria, Udine, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Angelis
mesh_terms: D051722:ADAM Proteins / Q000097:blood*; D000071120:ADAMTS13 Protein; D005260:Female; D006801:Humans; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood / Q000175:diagnosis / Q000628:therapy
chemical_list: D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human