title: Prognostic Role of Cell Cycle and Proliferative Markers in Clear Cell Renal Cell Carcinoma.
abstract: The cell cycle is one of the most important regulatory mechanisms of cellular growth and proliferation. Dysregulation of this pathway is thought to be the first step in carcinogenesis of renal cell carcinoma (RCC), important for tumor invasion and metastases. Multiple different parts and regulators of the cell cycle are detectable via assays like immunohistochemistry and have been studied extensively. This review aims to provide an overview of current data regarding individual cell cycle and proliferative markers and their association with clinicopathologic parameters and their impact on prognosis for patients with RCC. Furthermore, the value of marker combinations is discussed.
authors.affiliation: Department of Urology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9110, USA; Department of Urology, University of Muenster Medical Center, Albert-Schweitzer Campus 1, GB A1, Muenster D-48149, Germany.
authors.forename: Laura-Maria
authors.initials: LM
authors.lastname: Krabbe
authors.affiliation: Department of Urology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9110, USA.
authors.forename: Vitaly
authors.initials: V
authors.lastname: Margulis
authors.affiliation: Department of Urology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9110, USA. Electronic address: Yair.Lotan@UTSouthwestern.edu.
authors.forename: Yair
authors.initials: Y
authors.lastname: Lotan
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D002453:Cell Cycle; D049109:Cell Proliferation; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor
keywords: Cell cycle markers; Markers of proliferation; Prognostic marker; Renal cell carcinoma