title: First Total Synthesis of Gliomasolide C and Formal Total Synthesis of  Sch-725674.
abstract: Syntheses of two 14-membered macrolides Sch-725674 and Gliomasolide C are described here. The first total synthesis of Gliomasolide C, the short synthesis of Sch-725674, and regioselective Wacker oxidation of internal olefin are the highlights of this disclosure. In addition, a key macrocycle with orthogonal functionalities was designed and synthesized on a gram scale for the generation of analogues.
authors.affiliation: CSIR-National Chemical Laboratory, Division of Organic Chemistry, Dr. HomiBhabha Road, Pune, 411008, India
authors.forename: B
authors.initials: B
authors.lastname: Seetharamsingh
authors.forename: Pankaj V
authors.initials: PV
authors.lastname: Khairnar
authors.forename: D Srinivasa
authors.initials: DS
authors.lastname: Reddy
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D018942:Macrolides; C506328:Sch 725674; C000607400:gliomasolide C