title: Paclitaxel-Loaded β-Cyclodextrin-Modified Poly(Acrylic Acid) Nanoparticles through Multivalent Inclusion for Anticancer Therapy.
abstract: A nanoassembled drug delivery system for anticancer treatment, formed by the host-guest interactions between paclitaxel (PTX) and β-cyclodextrin (β-CD) modified poly(acrylic acid) (PCDAA), is successfully prepared. After such design, the aqueous solubility of PTX is greatly increased from 0.34 to 36.02 μg mL(-1), and the obtained PCDAA-PTX nanoparticles (PCDAA-PTX NPs) exhibit a sustained PTX release behavior in vitro. In vitro cytotoxicity finds that PCDAA-PTX NPs can accumulate significantly in tumor cells and remain the pharmacological activity of PTX. The in vivo real-time biodistribution of PCDAA-PTX NPs is investigated using near-infrared fluorescence imaging, indicating that the PCDAA-PTX NPs can effectively target to the tumor site by the enhanced permeability and retention effect in H22 tumor-bearing mice. Through in vivo antitumor examination, PCDAA-PTX NPs exhibit superior efficacy in impeding the tumor growth compared to the commercially available Taxol®.
authors.affiliation: Institute of Materials Engineering, National Laboratory of Solid State Microstructure, College of Engineering and Applied Sciences, Nanjing University, Nanjing, 210093, P.R. China.
authors.forename: Shanmei
authors.initials: S
authors.lastname: Yuan
authors.affiliation: Institute of Materials Engineering, National Laboratory of Solid State Microstructure, College of Engineering and Applied Sciences, Nanjing University, Nanjing, 210093, P.R. China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Chen
authors.affiliation: School of Electronic and Information Engineering, Yili Normal University, Yining, 835000, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Sheng
authors.affiliation: Institute of Materials Engineering, National Laboratory of Solid State Microstructure, College of Engineering and Applied Sciences, Nanjing University, Nanjing, 210093, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Hu
authors.affiliation: School of Electronic and Information Engineering, Yili Normal University, Yining, 835000, P.R. China.
authors.forename: Zhongying
authors.initials: Z
authors.lastname: Jiang
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000188:drug therapy*; D017239:Paclitaxel / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D047392:beta-Cyclodextrins / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000180:Acrylic Resins; D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D047392:beta-Cyclodextrins; C006903:carbopol 940; D017239:Paclitaxel
keywords: b-cyclodextrin; nanoparticles; paclitaxel; poly(acrylic acid)