title: Temporary changes in neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios, and mean platelet volume reflecting the inflammatory process after radioiodine therapy.
abstract: OBJECTIVE
  Data on the effects of radioiodine (RAI) therapy on systemic inflammation are very limited. The aim of this study is to explore alterations of subclinical systemic inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV), after RAI therapy in patients with differentiated thyroid carcinoma (DTC).
  
  
  METHODS
  We evaluated 57 DTC patients treated with RAI (RAI group), 37 DTC patients not treated with RAI (non-RAI control group), and 37 age-matched healthy individuals (healthy control group). NLR, PLR, and MPV levels were compared among the study groups; these were also examined after RAI in the RAI group.
  
  
  RESULTS
  Initially, NLR was significantly higher in the RAI group than in the healthy controls. NLR and PLR increased significantly and MPV decreased significantly 2 months after RAI therapy (P=0.021, 0.001, and 0.008, respectively). Although NLR and PLR levels decreased, they were still high compared with the preoperative values. MPV returned to normal levels at 6 months. These parameters did not change significantly in the non-RAI control group.
  
  
  CONCLUSIONS
  This is the first study to evaluate changes in NLR, PLR, and MPV after RAI therapy. Our findings suggest that NLR, PLR, and MPV changes indicate systemic inflammation that occurs after RAI therapy because of thyroid remnant tissue ablation.
authors.affiliation: Departments of aNuclear Medicine bEndocrinology and Metabolism, Internal Medicine cOtorhinolaryngology, School of Medicine, Yuzuncu Yil University, Van dDepartment of Nuclear Medicine, School of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Demir
authors.forename: Rifki
authors.initials: R
authors.lastname: Üçler
authors.forename: Erdem
authors.initials: E
authors.lastname: Sürücü
authors.forename: Mahfuz
authors.initials: M
authors.lastname: Turan
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Balli
authors.forename: Tarik
authors.initials: T
authors.lastname: Şengöz
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000473:pathology / Q000528:radiation effects*; D002452:Cell Count; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D007457:Iodine Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use*; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D008297:Male; D063847:Mean Platelet Volume; D009504:Neutrophils / Q000166:cytology / Q000528:radiation effects*; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000532:radiotherapy / Q000601:surgery; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes