title: Treatment of Nonalcoholic Fatty Liver Disease: The Role of Medical, Surgical, and Endoscopic Weight Loss.
abstract: Nonalcoholic fatty liver disease (NAFLD) represents a rapidly growing cause of chronic liver disease in the United States and is associated with significant morbidity and mortality, including progression to liver cirrhosis and hepatocellular carcinoma. NAFLD comprises a spectrum of liver conditions, ranging from simple steatosis to steatosis with inflammation (steatohepatitis) and progressive fibrosis. Weight loss represents a first line therapeutic modality for the management of NAFLD. Herein, we review the evidence base for medical, surgical, and endoscopic approaches to weight loss and their potential impact on the natural history of NAFLD.
authors.affiliation: Division of Gastroenterology, New York University School of Medicine, New York, NY, USA.
authors.forename: Violeta B
authors.initials: VB
authors.lastname: Popov
authors.affiliation: Yale Liver Center, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Joseph K
authors.initials: JK
authors.lastname: Lim
keywords: Bariatric surgery; Endoscopic therapy; Exercise; Fatty liver; Nonalcoholic steatohepatitis; Pharmacotherapy; Weight loss