title: Premature Progesterone Elevation Does Not Affect Pregnancy Outcome in High-Responder Patients Undergoing Short-Interval Coasting in IVF Cycles.
abstract: BACKGROUND We aimed to present the relationship between premature progesterone elevation (PPE) and clinical outcomes in high-responder patients who had a coasting period of <4 days in length due to their high risk of developing ovarian hyperstimulation syndrome (OHSS) and who were treated with a long-acting gonadotropin-releasing hormone agonist (GnRH-agonist) protocol in in vitro fertilization-embryo transfer (IVF-ET) cycles. MATERIAL AND METHODS This retrospective study was conducted at the University Hospital Assisted Reproductive Technology Center. The outcomes of 101 patients undergoing IVF- intracytoplasmic sperm injection (ICSI) cycles who showed a high response to COH (estradiol >4000 pg/ml and/or >20 follicles each ≥10 mm in diameter and at least 20% ≥15 mm) and who were coasted for <4 days were evaluated. Number of oocytes, 2 pronuclei (PN) embryos, implantation rate, and live birth rate were measured. RESULTS The incidence of PPE was 32.6%. Compared with those without PPE, patients with PPE had a higher number of oocytes retrieved. Total mature and fertilized oocytes and the mean number of embryos transferred were not significantly different between groups. Live birth rates (41.9% vs. 38.7%) and implantation rates (26.5% vs. 23%) were also not significantly divergent in the PPE and non-PPE groups, respectively. CONCLUSIONS P concentrations ≥1.3 ng/ml on the day of human chorionic gonadotropin (hCG) administration, designated in this study as PPE, does not appear to be related to adverse effects in terms of clinical outcomes in high-responder patients undergoing coasting <4 days due to their high risk of developing OHSS treated with a long-acting GnRH-a protocol in IVF-embryo transfer cycles.
authors.affiliation: Department of Obstetrics and Gynecology, Medipol University, School of Medicine, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Acet
authors.affiliation: Department of Obstetrics and Gynecology, Medipol University, School of Medicine, Istanbul, Turkey.
authors.forename: Lebriz Hale
authors.initials: LH
authors.lastname: Aktün
authors.affiliation: Department of Obstetrics and Gynecology, Fatih University, School of Medicine, Istanbul, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Başaranoğlu
authors.affiliation: Department of Obstetrics and Gynecology, Medipol University, School of Medicine, Istanbul, Turkey.
authors.forename: Betül
authors.initials: B
authors.lastname: Yorgunlar
authors.affiliation: Department of Obstetrics and Gynecology, Medicine Hospital, Istanbul, Turkey.
authors.forename: Tuba
authors.initials: T
authors.lastname: Acet
authors.affiliation: Department of Obstetrics and Gynecology, Bahçelievler State Hospital, Istanbul, Turkey.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Deregözü
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004624:Embryo Transfer / Q000379:methods; D004958:Estradiol / Q000097:blood; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood* / Q000517:prevention & control; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000097:blood*; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*
chemical_list: D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol