title: Lipid Profile in Post-Acute Coronary Syndrome Setting: Lipidic Risk Assessment in Young People beyond LDL-C.
abstract: This case-control study was carried out in Department of Cardiology, Mymensingh Medical College Hospital, Bangladesh, within the period from June 2009 to May 2010. A total 50 case of 18-45 years of age with first attack of acute coronary syndrome admitted in coronary care unit and 50 healthy controls of same age and sex distribution were studied. Among the lipid parameters, TC, HDL-C, LDL-C and non-HDL-C were significantly lower in cases than in controls. Apo B was significantly higher in the cases (98.7±25.1 mg/dl vs. 77.5±35.2 mg/dl in control). Importantly, among the cases with hyper Apo B condition, 25 (50.0%) had LDL-C level within normal limit, thus conventional lipid profile underestimated the ACS risk. In multivariate analysis Apo B was an independent determinant of ACS. Among the controls 23(46.0%) with high LDL-C had hyper Apo condition. Hyper-Apo B in these controls may cause acute coronary syndrome in future. The present study shows estimation of Apo B can predict basal or residual risk of acute coronary syndrome in young people, what from calculated LDL-C level cannot be inferred.
authors.affiliation: Dr Gana Pati Aditya, Assistant Professor, Department of Cardiology, Mymensingh Medical College, Mymensingh, Bangladesh; E-mail: ganapati.aditya@yahoo.com.
authors.forename: G P
authors.initials: GP
authors.lastname: Aditya
authors.forename: M A
authors.initials: MA
authors.lastname: Bari
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D000328:Adult; D001055:Apolipoproteins B / Q000097:blood; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D018570:Risk Assessment
chemical_list: D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D008055:Lipids