title: High Serum Level of β2-Microglobulin in Late Posttransplant Period Predicts Subsequent Decline in Kidney Allograft Function: A Preliminary Study.
abstract: BACKGROUND
  Identification of patients at risk for kidney allograft (KAG) failure beyond the first posttransplant year is an unmet need. We aimed to determine whether serum beta-2-microglobulin (β2MG) in the late posttransplant period could predict a decline in KAG function.
  
  
  METHODS
  We assessed a value of single measurement of serum β2MG at one to seventeen years after transplantation in predicting the estimated glomerular filtration rate (eGFR) and the decline in eGFR over a period of two years in 79 recipients of KAG.
  
  
  RESULTS
  At baseline serum β2MG concentration was higher (P = 0.011) in patients with allograft dysfunction: 8.67 ± 2.48 µg/mL versus those with satisfactory graft function: 6.67 ± 2.13 µg/mL. Higher β2MG independently predicted the lower eGFR, the drop in eGFR by ≥25% after one and two years, and the value of negative eGFR slope. When combined with proteinuria and acute rejection, serum β2MG had excellent power in predicting certain drop in eGFR after one year (AUC = 0.910). In conjunction with posttransplant time serum β2MG had good accuracy in predicting certain eGFR drop after two years (AUC = 0.821).
  
  
  CONCLUSIONS
  Elevated serum β2MG in the late posttransplant period is useful in identifying patients at risk for rapid loss of graft function.
authors.affiliation: Department of Laboratory Diagnostics and General Pathology, State Institution "Zaporizhzhia Medical Academy of Postgraduate Education Ministry of Health of Ukraine", 20 Winter Boulevard, Zaporizhzhia 69096, Ukraine.
authors.forename: Andriy V
authors.initials: AV
authors.lastname: Trailin
authors.affiliation: Department of Laboratory Diagnostics and General Pathology, State Institution "Zaporizhzhia Medical Academy of Postgraduate Education Ministry of Health of Ukraine", 20 Winter Boulevard, Zaporizhzhia 69096, Ukraine.
authors.forename: Marina V
authors.initials: MV
authors.lastname: Pleten
authors.affiliation: Department of Transplantology, Endocrine Surgery and Cardiovascular Surgery, State Institution "Zaporizhzhia Medical Academy of Postgraduate Education Ministry of Health of Ukraine", Zaporizhzhia Regional Hospital, 10 Orikhiv Highway, Zaporizhzhia 69050, Ukraine.
authors.forename: Tatiana I
authors.initials: TI
authors.lastname: Ostapenko
authors.affiliation: Department of Laboratory Diagnostics and General Pathology, State Institution "Zaporizhzhia Medical Academy of Postgraduate Education Ministry of Health of Ukraine", 20 Winter Boulevard, Zaporizhzhia 69096, Ukraine.
authors.forename: Nadiia F
authors.initials: NF
authors.lastname: Iefimenko
authors.affiliation: Department of Transplantology, Endocrine Surgery and Cardiovascular Surgery, State Institution "Zaporizhzhia Medical Academy of Postgraduate Education Ministry of Health of Ukraine", Zaporizhzhia Regional Hospital, 10 Orikhiv Highway, Zaporizhzhia 69050, Ukraine.
authors.forename: Olexander S
authors.initials: OS
authors.lastname: Nikonenko
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D051799:Delayed Graft Function / Q000097:blood*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D014184:Transplantation, Homologous / Q000009:adverse effects; D001613:beta 2-Microglobulin / Q000097:blood*
chemical_list: D015415:Biomarkers; D001613:beta 2-Microglobulin