title: Nasopharyngeal chordoma in a patient with a severe form of sleep-disordered breathing: A case report.
abstract: Nasopharyngeal chordoma is a rare type of malignant neoplasm that originates in the remnants of the notochord, a primitive tissue of embryonic origin preserved outside the axial skeleton. Approximately one-third of chordomas are located in the base of the skull, in the midline of the body. The slow growth rate of the tumor, which gradually fills the nasopharyngeal cavity, contributes to a delayed oncological diagnosis. Among its isolated and non-specific symptoms, the obstruction of the nasopharynx is dominant, thus, sleep-disordered breathing (SDB) may occur. The current study presents the case of a 32-year-old female patient who was incidentally diagnosed with a nasopharyngeal chordoma during a diagnostic examination for SDB. The diagnostic examination was performed as a part of a research program for pathologically obese patients who qualified for bariatric surgery. Following tumor resection, a significant improvement in various polysomnographic parameters occurred, including a decrease in the apnea hypopnea index from 53.5 to 6.4 and an increase in the mean saturation rate from 92.5 to 95%, confirming that an association exists between tumor obstruction of the nasopharynx and SDB. The incidental diagnosis of this rare type of neoplasm drew attention to diagnostic and therapeutic problems associated with nasopharyngeal chordomas. Furthermore, it indicated the necessity for the accurate laryngological examination of patients with SDB.
authors.affiliation: Department of Otorhinolaryngology, Medical University of Warsaw, Warsaw 00-739, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Radzikowska
authors.affiliation: Department of Otorhinolaryngology, Medical University of Warsaw, Warsaw 00-739, Poland.
authors.forename: Zuzanna
authors.initials: Z
authors.lastname: Gronkiewicz
authors.affiliation: Department of Otolaryngology and Head and Neck Disease, University of Varmia and Mazuria School of Medicine, Olsztyn 10-082, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kukwa
authors.affiliation: Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw 02-005, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Lisik
authors.affiliation: Department of Oncology, Military Institute of Medicine, Warsaw 04-141, Poland.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Czarnecka
authors.affiliation: Department of Otorhinolaryngology, Medical University of Warsaw, Warsaw 00-739, Poland.
authors.forename: Antoni
authors.initials: A
authors.lastname: Krzeski
authors.affiliation: Department of Otorhinolaryngology, Medical University of Warsaw, Warsaw 00-739, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kukwa
keywords: chordoma; nasopharyngeal tumor; sleep-disordered breathing