title: Gold-catalyzed cyclization and cycloisomerization of yne-tethered ynamide: the significance of a masked enol-equivalent of an amide.
abstract: This perspective briefly describes the conceptual manifestation of a Brønsted acid promoted Au-catalyzed cyclization of yne-tethered ynamides for the construction of novel N-heterocycles. A hetero-atom assisted intramolecular 6-endo-dig cyclization of a transient ketene N,O-acetal (a masked enol-ether of an amide), generated from an ambivalent ynamide through the attack of p-TsOH, with a Au-activated yne-motif creates dihydropyridinones and benzo[f]dihydroisoquinolones. The Au(I)-catalyzed cycloisomerization of an alkyne-tethered ketene N,N-acetal to manufacture unusual cyclobutene-fused azepine scaffolds is also highlighted.
authors.affiliation: School of Chemistry, University of Hyderabad, Prof. C R Rao Road. Gachibowli, Hyderabad, Telangana-500046, India. akhilchemistry12@gmail.com.
authors.forename: Sanatan
authors.initials: S
authors.lastname: Nayak
authors.forename: B
authors.initials: B
authors.lastname: Prabagar
authors.forename: Akhila K
authors.initials: AK
authors.lastname: Sahoo