title: No association between glucose at age 30 and aortic diameter at age 65 in men: a population-based study.
abstract: OBJECTIVE
  Impaired glucose metabolism and diabetes mellitus has been linked to a decreased risk for abdominal aortic aneurysm development in men. We evaluated potential relationships between blood glucose levels in 1722 men with mean age 34 years and their aortic diameter measured by ultrasound at age 65 years.
  
  
  METHODS
  Prospective cohort study.
  
  
  RESULTS
  Mean follow-up between baseline glucose investigation and aortic ultrasound was 32.8 ± 1.8 years. There was no correlation between baseline blood glucose and later aortic diameter (r = 0.035, p = 0.146), whereas a weak correlation between body mass index (BMI) and aortic diameter was observed (r = 0.097 p < 0.001). In a partial correlation between aortic diameter and glucose levels adjusted for BMI, the correlation did not change (r = 0.011, p = 0.66). Neither were there any significant differences in mean aortic diameter between men belonging to different quartiles of baseline blood glucose levels (19.5, 19.1, 19.6 and 19.7 mm, p = 0.18).
  
  
  CONCLUSIONS
  Fasting blood glucose in 33-year-old men was not associated with their aortic diameter at age 65 years. Potential pathophysiological processes linking disturbed glucose metabolism to a decreased risk for development of abdominal aortic aneurysm in men are therefore probably not relevant until later in life.
authors.affiliation: a Clinical Research Unit, Department of Internal Medicine , Skåne University Hospital , Malmö , Sweden ;
authors.forename: Margaretha
authors.initials: M
authors.lastname: Persson
authors.affiliation: b Department of Vascular Diseases , Skåne University Hospital , Malmö , Sweden.
authors.forename: Moncef
authors.initials: M
authors.lastname: Zarrouk
authors.affiliation: b Department of Vascular Diseases , Skåne University Hospital , Malmö , Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Holst
authors.affiliation: a Clinical Research Unit, Department of Internal Medicine , Skåne University Hospital , Malmö , Sweden ;
authors.forename: Peter M
authors.initials: PM
authors.lastname: Nilsson
authors.affiliation: b Department of Vascular Diseases , Skåne University Hospital , Malmö , Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Gottsäter
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging*; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging* / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis*; D004108:Dilatation, Pathologic; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011159:Population Surveillance; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D013548:Sweden / Q000453:epidemiology; D013997:Time Factors; D018084:Ultrasonography, Interventional
chemical_list: D015415:Biomarkers; D001786:Blood Glucose
keywords: Abdominal aortic aneurysm; aortic diameter; blood glucose