title: Follicular dendritic cell sarcoma of mediastinum: a key role of radiotherapy in a multidisciplinary approach.
abstract: Follicular dendritic cell sarcoma is a rare and aggressive tumor and its management is a major clinical challenge. Surgery is considered the mainstay of treatment and no adjuvant approach has demonstrated the ability to reduce the rate of relapses. We report on a case of a man with a 26-year clinical history of mediastinal follicular dendritic cell sarcoma, with several relapses after multiple surgical interventions. The impact of chemotherapy was very small, unlike the radiation therapy that was performed twice, with an interval time of 8 years, through an intensity-modulated technique and an altered fractionation schedule.
authors.affiliation: AOU 'Policlinico-Vittorio Emanuele' - U.O. Radiodiagnostica e Radioterapia Oncologica, Università di Catania, Via Santa Sofia n. 78, 95125 Catania, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Spatola
authors.affiliation: AOU 'Policlinico-Vittorio Emanuele' - U.O. Chirurgia Toracica, Università di Catania, Via Santa Sofia n. 78, 95125 Catania, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Migliore
authors.affiliation: AOU 'Policlinico-Vittorio Emanuele' - U.O. Radiodiagnostica e Radioterapia Oncologica, Università di Catania, Via Santa Sofia n. 78, 95125 Catania, Italy.
authors.forename: Rocco Luca
authors.initials: RL
authors.lastname: Emanuele Liardo
authors.affiliation: AOU 'Policlinico-Vittorio Emanuele' - U.O. Radiodiagnostica e Radioterapia Oncologica, Università di Catania, Via Santa Sofia n. 78, 95125 Catania, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Bevilacqua
authors.affiliation: AOU 'Policlinico-Vittorio Emanuele' - U.O. Radiodiagnostica e Radioterapia Oncologica, Università di Catania, Via Santa Sofia n. 78, 95125 Catania, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Luigi
authors.affiliation: AOU 'Policlinico-Vittorio Emanuele' - U.O. Radiodiagnostica e Radioterapia Oncologica, Università di Catania, Via Santa Sofia n. 78, 95125 Catania, Italy.
authors.forename: Salamone
authors.initials: S
authors.lastname: Vincenzo
authors.affiliation: AOU 'Policlinico-Vittorio Emanuele' - U.O. Radiodiagnostica e Radioterapia Oncologica, Università di Catania, Via Santa Sofia n. 78, 95125 Catania, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Tocco
authors.affiliation: AOU 'Policlinico-Vittorio Emanuele' - U.O. Radiodiagnostica e Radioterapia Oncologica, Università di Catania, Via Santa Sofia n. 78, 95125 Catania, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pagana
authors.affiliation: AOU 'Policlinico-Vittorio Emanuele' - U.O. Radiodiagnostica e Radioterapia Oncologica, Università di Catania, Via Santa Sofia n. 78, 95125 Catania, Italy.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Militello
authors.affiliation: AOU 'Policlinico-Vittorio Emanuele' - U.O. Chirurgia Toracica, Università di Catania, Via Santa Sofia n. 78, 95125 Catania, Italy.
authors.forename: Damiano
authors.initials: D
authors.lastname: Calvo
authors.affiliation: AOU 'Policlinico-Vittorio Emanuele' - U.O. Chirurgia Toracica, Università di Catania, Via Santa Sofia n. 78, 95125 Catania, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Criscione
authors.affiliation: AOU 'Policlinico-Vittorio Emanuele' - U.O. Radiodiagnostica e Radioterapia Oncologica, Università di Catania, Via Santa Sofia n. 78, 95125 Catania, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Privitera
mesh_terms: D000328:Adult; D054740:Dendritic Cell Sarcoma, Follicular / Q000473:pathology* / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008482:Mediastinum / Q000473:pathology* / Q000528:radiation effects*; D009364:Neoplasm Recurrence, Local / Q000473:pathology
keywords: FDCS; IMRT; low-dose fractionation; re-irradiation