title: Photocleavable Hydrogels for Light-Triggered siRNA Release.
abstract: A photocleavable hydrogel system for on-demand delivery of genetic material is reported. The release of short interfering RNAs can be triggered by the application of UV light without any loss in bioactivity. This approach provides a promising external stimulus-based nucleic acid delivery platform for applications in disease therapeutics and tissue regeneration.
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
authors.forename: Cong Truc
authors.initials: CT
authors.lastname: Huynh
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
authors.forename: Minh Khanh
authors.initials: MK
authors.lastname: Nguyen
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
authors.forename: Gulen Yesilbag
authors.initials: GY
authors.lastname: Tonga
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
authors.forename: Lionel
authors.initials: L
authors.lastname: Longé
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
authors.forename: Eben
authors.initials: E
authors.lastname: Alsberg
mesh_terms: D018014:Gene Transfer Techniques; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008027:Light; D009696:Nucleic Acids / Q000737:chemistry; D034741:RNA, Small Interfering / Q000737:chemistry*; D012038:Regeneration / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods
chemical_list: D020100:Hydrogels; D009696:Nucleic Acids; D034741:RNA, Small Interfering
keywords: UV-controllable release; controlled release; on-demand release; photolabile hydrogels; siRNA