title: Polymorphisms Associated with Age at Onset in Patients with Moderate-to-Severe Plaque Psoriasis.
abstract: Psoriasis is a chronic skin disease in which genetics play a major role. Although many genome-wide association studies have been performed in psoriasis, knowledge of the age at onset remains limited. Therefore, we analyzed 173 single-nucleotide polymorphisms in genes associated with psoriasis and other autoimmune diseases in patients with moderate-to-severe plaque psoriasis type I (early-onset, <40 years) or type II (late-onset, ≥40 years) and healthy controls. Moreover, we performed a comparison between patients with type I psoriasis and patients with type II psoriasis. Our comparison of a stratified population with type I psoriasis (n = 155) and healthy controls (N = 197) is the first to reveal a relationship between the CLMN, FBXL19, CCL4L, C17orf51, TYK2, IL13, SLC22A4, CDKAL1, and HLA-B/MICA genes. When we compared type I psoriasis with type II psoriasis (N = 36), we found a significant association between age at onset and the genes PSORS6, TNF-α, FCGR2A, TNFR1, CD226, HLA-C, TNFAIP3, and CCHCR1. Moreover, we replicated the association between rs12191877 (HLA-C) and type I psoriasis and between type I and type II psoriasis. Our findings highlight the role of genetics in age of onset of psoriasis.
authors.affiliation: Clinical Pharmacology Service, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP), Universidad Autónoma de Madrid (UAM), 28006 Madrid, Spain.
authors.forename: Rocío
authors.initials: R
authors.lastname: Prieto-Pérez
authors.affiliation: Dermatology Service, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa (IP), 28006 Madrid, Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Solano-López
authors.affiliation: Clinical Pharmacology Service, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP), Universidad Autónoma de Madrid (UAM), 28006 Madrid, Spain ; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Cabaleiro
authors.affiliation: Clinical Pharmacology Service, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP), Universidad Autónoma de Madrid (UAM), 28006 Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Román
authors.affiliation: Clinical Pharmacology Service, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP), Universidad Autónoma de Madrid (UAM), 28006 Madrid, Spain.
authors.forename: Dolores
authors.initials: D
authors.lastname: Ochoa
authors.affiliation: Clinical Pharmacology Service, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP), Universidad Autónoma de Madrid (UAM), 28006 Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Talegón
authors.affiliation: Dermatology Service, Hospital Universitario Gregorio Marañón, 28007 Madrid, Spain.
authors.forename: Ofelia
authors.initials: O
authors.lastname: Baniandrés
authors.affiliation: Dermatology Service, Hospital Universitario Fundación Alcorcón, 28922 Madrid, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: López-Estebaranz
authors.affiliation: Dermatology Service, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: de la Cueva
authors.affiliation: Dermatology Service, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa (IP), 28006 Madrid, Spain.
authors.forename: Esteban
authors.initials: E
authors.lastname: Daudén
authors.affiliation: Clinical Pharmacology Service, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP), Universidad Autónoma de Madrid (UAM), 28006 Madrid, Spain ; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Abad-Santos
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D015796:HLA-B27 Antigen / Q000235:genetics* / Q000276:immunology; D015236:HLA-C Antigens / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D017422:Sequence Analysis, DNA; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000276:immunology; D000096985:Calponins
chemical_list: D015796:HLA-B27 Antigen; D015236:HLA-C Antigens; D008565:Membrane Proteins; D014409:Tumor Necrosis Factor-alpha; C435688:CLMN protein, human; D000096985:Calponins; C090660:HLA-B protein, human