title: SYNJ2 variant rs9365723 is associated with colorectal cancer risk in Chinese Han population.
abstract: OBJECTIVE
  Colorectal cancer (CRC) is the third most common cancer and fourth leading cause of cancer mortality, and twin studies have shown that approximately 35% of the variation in susceptibility to CRC involves inherited genetic differences. We sought to investigate potential genetic associations between some single nucleotide polymorphisms (SNPs) and the risk of CRC in the Chinese Han population.
  
  
  METHODS
  We conducted a case-control study including 269 cases and 309 controls. Sixteen SNPs associated with CRC risk were selected from previous genome-wide association studies and genotyped using Sequenom MassARRAY technology. Odds ratios and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusting for age and gender.
  
  
  RESULTS
  Using the chi-squared test we found that rs9365723 was associated with CRC risk (p = 0.012). With genetic model analysis, the genotype A/G-G/G (OR = 1.50; 95% CI 1.02-2.21; p = 0.038) of rs9365723 showed an increased risk of CRC in the dominant model. Furthermore, we found that rs9365723 was associated with an increased risk only for colon cancer but not rectal cancer (p = 0.009 and p = 0.414, respectively).
  
  
  CONCLUSIONS
  Our results, combined with previous studies, suggest that rs9365723, located on SYNJ2, is associated with the risk of CRC in a Chinese population. Thus, SYNJ2 may play a role in the development of CRC, especially colon cancer.
authors.affiliation: Second Department of General Surgery, Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an - China.
authors.forename: Qingguo
authors.initials: Q
authors.lastname: Du
authors.affiliation: Department of Internal Medicine, Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an - China.
authors.forename: Xueyan
authors.initials: X
authors.lastname: Guo
authors.affiliation: School of Life Sciences, Northwest University, Xi'an - China.
authors.forename: Xiyang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Northwest University, Xi'an - China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Xidian Group Hospital, Xi'an - China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Second Department of General Surgery, Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an - China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Wang
authors.affiliation: Second Department of General Surgery, Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an - China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Second Department of General Surgery, Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an - China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Mao
authors.affiliation: The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an - China.
authors.forename: Jun
authors.initials: J
authors.lastname: Luo
authors.affiliation: School of Life Sciences, Northwest University, Xi'an - China.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an - China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an - China.
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D000099182:Phosphoinositide 5-Phosphatases
chemical_list: D010744:Phosphoric Monoester Hydrolases; D000099182:Phosphoinositide 5-Phosphatases