title: How Accurate Are International Classification of Diseases-10 Diagnosis Codes in Detecting Influenza and Pertussis Hospitalizations in Children?
abstract: Influenza and pertussis are major causes of pediatric morbidity. We measured the accuracy of their International Classification of Diseases (ICD-10-AM) diagnosis codes using linked population-based laboratory and hospital data in 245,249 children. Influenza diagnosis codes had high specificity (98.6%) and modest positive predictive value (PPV; 84.1%) and sensitivity (86.1%, 95% CI: 83.4%-88.6%) for a laboratory-confirmed episode. For pertussis diagnosis codes, PPV (86.8%) and specificity (98.9%) were high, but sensitivity was poor (27.8%, 95% CI: 23.5%-32.4%). Measures varied according to age, remoteness, Aboriginality, severity, and detection method. Both laboratory and hospitalization data are needed to accurately determine the burden of pediatric influenza and pertussis.
authors.affiliation: Division of Population Sciences, Telethon Institute for Child Health Research, Centre for Child Health Research, and.
authors.forename: Hannah C
authors.initials: HC
authors.lastname: Moore
authors.affiliation: Division of Population Sciences, Telethon Institute for Child Health Research, Centre for Child Health Research, and.
authors.forename: Deborah
authors.initials: D
authors.lastname: Lehmann
authors.affiliation: Division of Population Sciences, Telethon Institute for Child Health Research, Centre for Child Health Research, and.
authors.forename: Nicholas
authors.initials: N
authors.lastname: de Klerk
authors.affiliation: School of Pathology and Laboratory Medicine, University of Western Australia Division of Microbiology and Infectious Diseases, PathWest Laboratory Medicine WA, QEII Medical Centre.
authors.forename: David W
authors.initials: DW
authors.lastname: Smith
authors.affiliation: School of Paediatrics and Child Health, University of Western Australia Department of Paediatric and Adolescent Medicine, Princess Margaret Hospital for Children.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Richmond
authors.affiliation: Department of Microbiology, PathWest Laboratory Medicine WA, Princess Margaret Hospital for Children, Perth, Australia.
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Keil
authors.affiliation: School of Paediatrics and Child Health, University of Western Australia Department of Paediatric and Adolescent Medicine, Princess Margaret Hospital for Children Department of Microbiology, PathWest Laboratory Medicine WA, Princess Margaret Hospital for Children, Perth, Australia.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Blyth
keywords: International Classification of Disease (ICD) Codes; hospitalization; influenza; laboratory confirmation; pertussis; sensitivity; specificity