title: Effect of oral administration of Kudoa septempunctata genotype ST3 in adult BALB/c mice.
abstract: Kudoa septempunctata (Myxozoa: Multivalvulida) infects the muscles of olive flounder (Paralichthys olivaceus, Paralichthyidae) in the form of spores. To investigate the effect of K. septempunctata spores in mammals, adult BALB/c mice were fed with spores of K. septempunctata genotype ST3 (1.35 × 10(5) to 1.35 × 10(8) spores/mouse). After ingestion of spores, the mice remained clinically normal during the 24-h observation period. No spores were found in any tissue examined by histopathological screening. Quantitative PCR screening of the K. septempunctata 18S rDNA gene revealed that the K. septempunctata spores were detected only in the stool samples from the spore-fed groups. Collectively, these findings suggest that K. septempunctata spores are excreted in faeces and do not affect the gastrointestinal tract of adult mice.
authors.affiliation: School of Medicine, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Meejung
authors.initials: M
authors.lastname: Ahn
authors.affiliation: College of Veterinary Medicine, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Hochoon
authors.initials: H
authors.lastname: Woo
authors.affiliation: Ocean and Fisheries Research Institute, Jeju Special Self-Governing Province, Pyoseon-myeon, Segwipo-si, Jeju 63629, Republic of Korea.
authors.forename: Bongjo
authors.initials: B
authors.lastname: Kang
authors.affiliation: Ocean and Fisheries Research Institute, Jeju Special Self-Governing Province, Pyoseon-myeon, Segwipo-si, Jeju 63629, Republic of Korea.
authors.forename: Yeounghwan
authors.initials: Y
authors.lastname: Jang
authors.affiliation: College of Veterinary Medicine, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Taekyun
authors.initials: T
authors.lastname: Shin
mesh_terms: D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics; D004275:DNA, Ribosomal / Q000235:genetics; D004198:Disease Susceptibility; D003576:Electron Transport Complex IV / Q000235:genetics; D005243:Feces / Q000469:parasitology; D005393:Fish Diseases / Q000469:parasitology; D005432:Flounder / Q000469:parasitology; D016266:Food Parasitology; D005838:Genotype; D058507:Host Specificity; D007411:Intestinal Diseases, Parasitic / Q000635:transmission*; D007413:Intestinal Mucosa / Q000469:parasitology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D018482:Muscle, Skeletal / Q000469:parasitology; D055764:Myxozoa / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D010273:Parasitic Diseases, Animal / Q000635:transmission*; D012337:RNA, Ribosomal, 18S / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D016415:Sequence Alignment
chemical_list: D004272:DNA, Mitochondrial; D004275:DNA, Ribosomal; D012337:RNA, Ribosomal, 18S; D003576:Electron Transport Complex IV