title: A feedforward loop of NLRC5 (de)ubiquitination keeps IKK-NF-κB in check.
abstract: Many receptors signal via adaptors to the IKK-NF-κB axis, transducing extracellular cues to transcriptional regulation. In this issue, Meng et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201505091) reveal that the IKK regulator NLRC5 shapes NF-κB activity through a feedforward loop of NLRC5 ubiquitination and deubiquitination, highlighting a new pathway modulating IKK-NF-κB activity.
authors.affiliation: Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21701 huy2@mail.nih.gov.
authors.forename: Yinling
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000818:Animals; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry*; D052002:NF-kappa B p50 Subunit / Q000378:metabolism*; D025801:Ubiquitin / Q000737:chemistry*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D052002:NF-kappa B p50 Subunit; D025801:Ubiquitin