title: Predictive value of autoantibodies from anti-CCP2, anti-MCV and anti-human citrullinated fibrinogen tests, in early rheumatoid arthritis patients with rapid radiographic progression at 1 year: results from the ESPOIR cohort.
abstract: OBJECTIVE
  We compared the ability of antibodies against cyclic citrullinated peptides (anti-CCP2), against mutated citrullinated vimentin (anti-MCV) and against citrullinated fibrinogen (AhFibA) to predict 1 year rapid radiographic progression (RRP; total Sharp score variation ≥5 points), in early rheumatoid arthritis (RA).
  
  
  METHODS
  We analysed 566 patients from the ESPOIR cohort with early RA fulfilling the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria at year 1. We assayed the 3 anticitrullinated peptide antibodies (ACPA) tests on baseline sera. We compared the performance of these 3 ACPA tests to predict first-year RRP, by comparing areas under the receiver operating characteristic curves (ROCs). We assessed the 1 year RRP risk by ACPA titres. We used a logistic multivariate regression to analyse RRP risk in terms either of ACPA positivity or titre: high (>3 times the N cut-off) and low (1 to 3N).
  
  
  RESULTS
  145 patients displayed RRP. Areas under the ROCs were similar (0.60) for the 3 tests. High ACPA titres were associated with 1 year RRP, whatever the test was, and with similar ORs. Low+ anti-MCV titres were not associated with 1-year RRP, whereas low+ anti-CCP2 titres (p=0.0226) and low+ AhFibA titres (p=0.0332) were significantly associated. In multivariate analysis, 1 year RRP was associated with anti-CCP2 positivity (p<0.0001), AhFibA positivity (p<0.0001) and high anti-MCV titres (p<0.0001).
  
  
  CONCLUSIONS
  Anti-CCP2 antibodies and AhFibA were predictive of 1 year RRP in early RA whatever their titre was, whereas only high anti-MCV antibody titres were predictive, potentially making them more discriminant to predict 1 year RRP risk.
authors.affiliation: Rheumatology Center, Purpan University Hospital , Toulouse , France ; UMR 1043, INSERM, CPTP , Toulouse , France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Degboé
authors.affiliation: Rheumatology Center, Purpan University Hospital , Toulouse , France ; UMR 1043, INSERM, CPTP , Toulouse , France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Constantin
authors.affiliation: Rheumatology Center, Purpan University Hospital , Toulouse , France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Nigon
authors.affiliation: Rheumatology Department , La Cavale Blanche Hospital , Brest , France.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Tobon
authors.affiliation: Laboratory of Epidermis Differentiation and Rheumatoid Autoimmunity , UMR CNRS 5165, INSERM 1056 , Toulouse , France ; Laboratory of Cell Biology and Cytology , Purpan University Hospital , Toulouse , France.
authors.forename: Martin
authors.initials: M
authors.lastname: Cornillet
authors.affiliation: Rheumatology Department , Pellegrin University Hospital , Bordeaux , France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Schaeverbeke
authors.affiliation: INSERM U1173, UFR des Sciences de la Santé, University Versailles Saint Quentin , Montigny-Le-Bretonneux , France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Chiocchia
authors.affiliation: UF Immunology Autoimmunity & Hypersensitivity , Bichat-Claude Bernard Hospital, APHP , Paris , France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Nicaise-Roland
authors.affiliation: Laboratory of Epidermis Differentiation and Rheumatoid Autoimmunity , UMR CNRS 5165, INSERM 1056 , Toulouse , France ; Laboratory of Cell Biology and Cytology , Purpan University Hospital , Toulouse , France.
authors.forename: Leonor
authors.initials: L
authors.lastname: Nogueira
authors.affiliation: Laboratory of Epidermis Differentiation and Rheumatoid Autoimmunity , UMR CNRS 5165, INSERM 1056 , Toulouse , France ; Laboratory of Cell Biology and Cytology , Purpan University Hospital , Toulouse , France.
authors.forename: Guy
authors.initials: G
authors.lastname: Serre
authors.affiliation: Rheumatology Center, Purpan University Hospital , Toulouse , France ; UMR 1043, INSERM, CPTP , Toulouse , France.
authors.forename: Alain
authors.initials: A
authors.lastname: Cantagrel
authors.affiliation: Rheumatology Center, Purpan University Hospital , Toulouse , France ; UMR 1027, INSERM, University Paul Sabatier Toulouse III , Toulouse , France.
authors.forename: Adeline
authors.initials: A
authors.lastname: Ruyssen-Witrand
keywords: Ant-CCP; Autoimmunity; Early Rheumatoid Arthritis