title: Lipoic acid reduces inflammation in a mouse focal cortical experimental autoimmune encephalomyelitis model.
abstract: Cortical lesions are a crucial part of MS pathology and it is critical to determine that new MS therapies have the ability to alter cortical inflammatory lesions given the differences between white and gray matter lesions. We tested lipoic acid (LA) in a mouse focal cortical EAE model. Brain sections were stained with antibodies against CD4, CD11b and galectin-3. Compared with vehicle, treatment with LA significantly decreased CD4+ and galectin-3+ immune cells in the brain. LA treated mice had fewer galectin-3+ cells with no projections indicating decrease in the number of infiltrating monocytes. LA significantly reduces inflammation in a focal cortical model of MS.
authors.affiliation: Department of Neurology, Oregon Health & Science University, L226, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States. Electronic address: chaudhar@ohsu.edu.
authors.forename: Priya
authors.initials: P
authors.lastname: Chaudhary
authors.affiliation: Department of Neurology, Oregon Health & Science University, L226, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States; Research, Department of Veteran Affairs Medical Center, 3710 SW U.S. Veterans Hospital Road, Portland, OR 97239, United States.
authors.forename: Gail
authors.initials: G
authors.lastname: Marracci
authors.affiliation: Department of Neurology, Oregon Health & Science University, L226, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States.
authors.forename: Danielle
authors.initials: D
authors.lastname: Galipeau
authors.affiliation: Department of Neurology, Oregon Health & Science University, L226, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States.
authors.forename: Edvinas
authors.initials: E
authors.lastname: Pocius
authors.affiliation: Department of Neurology, Oregon Health & Science University, L226, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States.
authors.forename: Brooke
authors.initials: B
authors.lastname: Morris
authors.affiliation: Department of Neurology, Oregon Health & Science University, L226, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States; Research, Department of Veteran Affairs Medical Center, 3710 SW U.S. Veterans Hospital Road, Portland, OR 97239, United States; Neurology Services, Department of Veteran Affairs Medical Center, Portland, OR 97239, United States.
authors.forename: Dennis
authors.initials: D
authors.lastname: Bourdette
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D039481:CD11b Antigen / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology*; D016207:Cytokines / Q000378:metabolism / Q000494:pharmacology; D004195:Disease Models, Animal; D004660:Encephalitis / Q000188:drug therapy* / Q000209:etiology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000150:complications* / Q000473:pathology*; D005260:Female; D037502:Galectin 3 / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000276:immunology; D010446:Peptide Fragments / Q000276:immunology; D018709:Statistics, Nonparametric; D008063:Thioctic Acid / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000975:Antioxidants; D039481:CD11b Antigen; D016207:Cytokines; D037502:Galectin 3; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; C445081:myelin oligodendrocyte glycoprotein (35-55); D008063:Thioctic Acid
keywords: Cortical lesions; Focal EAE; Immunofluorescence; Inflammation; Multiple sclerosis