title: Briarenolides U-Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae).
abstract: Five new 13,14-epoxybriarane diterpenoids, briarenolides U-Y (1-5), were isolated from the octocoral Briareum sp. The structures of briaranes 1-5 were elucidated by spectroscopic methods. Briarenolides U-Y (1-5) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
authors.affiliation: Department of Marine Biotechnology &amp; Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. gobetter04@yahoo.com.tw.|National Museum of Marine Biology &amp; Aquarium, Pingtung 944, Taiwan. gobetter04@yahoo.com.tw.
authors.forename: Yin-Di
authors.initials: YD
authors.lastname: Su
authors.affiliation: Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. kuma0401@gmail.com.
authors.forename: Tung-Ying
authors.initials: TY
authors.lastname: Wu
authors.affiliation: Department of Marine Biotechnology &amp; Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.|Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University &amp; Academia Sinica, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.affiliation: Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan. a081001@mail.tsmh.org.tw.|Department of Beauty Science, Meiho University, Pingtung 912, Taiwan. a081001@mail.tsmh.org.tw.
authors.forename: Ching-Chyuan
authors.initials: CC
authors.lastname: Su
authors.affiliation: National Museum of Marine Biology &amp; Aquarium, Pingtung 944, Taiwan. kb5634@yahoo.com.tw.|Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan. kb5634@yahoo.com.tw.
authors.forename: Yu-Hsin
authors.initials: YH
authors.lastname: Chen
authors.affiliation: National Museum of Marine Biology &amp; Aquarium, Pingtung 944, Taiwan. jay0404@gmail.com.|Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University &amp; Academia Sinica, Kaohsiung 804, Taiwan. jay0404@gmail.com.
authors.forename: Yu-Chia
authors.initials: YC
authors.lastname: Chang
authors.affiliation: Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@mail.cmu.edu.tw.
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.affiliation: Department of Marine Biotechnology &amp; Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.|Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University &amp; Academia Sinica, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
authors.affiliation: Department of Marine Biotechnology &amp; Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.|National Museum of Marine Biology &amp; Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.|Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. pjsung@nmmba.gov.tw.|Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. pjsung@nmmba.gov.tw.|Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000378:metabolism*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D051546:Cyclooxygenase 2 / Q000187:drug effects / Q000378:metabolism; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects / Q000378:metabolism; D013057:Spectrum Analysis
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D008070:Lipopolysaccharides; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2
keywords: Briareum; COX-2; anti-inflammatory; briarane; iNOS; octocoral