title: The MIF -173G/C gene polymorphism increase gastrointestinal cancer and hematological malignancy risk: evidence from a meta-analysis and FPRP test.
abstract: The macrophage migration inhibitory factor (MIF) -173G/C gene polymorphism has been implicated in the susceptibility to cancer, but the results are not conclusive. So the aim of study to investigate the association between MIF -173G/C gene polymorphism and cancer risk by a comprehensive meta-analysis. We searched the PubMed, Embase, Wanfang and China National Knowledge Internet (CNKI) databases, with the last updated search being performed on May 24, 2015. The odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the association. Statistical analysis was performed by STATA 11.0 software. Finally, 7,253 participants from 15 studies were included in the meta-analysis. The results of meta-analysis indicated the significant association between MIF -173G/C gene polymorphism and cancer susceptibility, especially in Asians (C vs.
  1.22, 95% CI=1.00-1.50). In addition, the significant relationship between MIF -173G/C gene polymorphism and gastrointestinal tumors (CC+CG vs.
  1.25, 95% CI=1.05-1.50), hematological malignancy (CC+CG vs.
  1.27, 95% CI=1.03-1.56), gynecolgical tumors (CC vs. CG+
  1.51, 95% CI=1.04-2.19) risk was found. However, to avoid the "false positive report", we investigated the significant associations observed in the present meta-analysis by the false positive report probabilities (FPRPs) test. Interestingly, the results of FPRP test indicated the MIF -173G/C gene polymorphism only associated with gastrointestinal cancer and hematological malignancy risk (FPRP=0.132, 0.067 respectively) at the level of a prior probability is 0.1. Therefore, the meta-analysis suggested MIF -173G/C gene polymorphism would be a risk factor for the gastrointestinal cancer and hematological malignancy.
authors.affiliation: Department of Respiratory and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan University Chengdu, Sichuan, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Tong
authors.affiliation: Department of Neurological Surgery, The First Affiliated Hospital of Kunming Medical University Kunming, Yunnan, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Zheng
authors.affiliation: The Faculty of Nursing, Luzhou Medical College Luzhou, Sichuan, China.
authors.forename: Qiaoyi
authors.initials: Q
authors.lastname: Tong
authors.affiliation: Department of Respiratory and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan University Chengdu, Sichuan, China.
authors.forename: Sitong
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Respiratory and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan University Chengdu, Sichuan, China.
authors.forename: Sifeng
authors.initials: S
authors.lastname: Peng
authors.affiliation: Department of Respiratory and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan University Chengdu, Sichuan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Respiratory and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan University Chengdu, Sichuan, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Fan
keywords: Cancer; FPRP; MIF; meta-analysis; polymorphism; susceptibility