title: Postoperative Serum CEA Level is a More Significant Prognostic Factor than Post/Preoperative Serum CEA Ratio in Non-small Cell Cancer Patients.
abstract: BACKGROUND
  In non-small cell lung cancer (NSCLC) patients with preoperative high serum carcinoembryonic antigen (CEA) level, patients with a persistently high serum CEA level after surgery have been reported to have a poor prognosis. In addition, in other cancers, the post/preoperative serum CEA ratio has been reported as a useful parameter.
  
  
  METHODS
  We enrolled 123 NSCLC patients with preoperative high CEA levels (≥ 5 ng/mL) who underwent curative surgery between 2004 and 2011. Prognostic significance of postoperative serum CEA level and the CEA ratio was examined.
  
  
  RESULTS
  The 5-year survival of patients with persistently high serum CEA level after surgery was poor. On the other hand, patients with normal postoperative serum CEA levels had significant favorable prognosis. The patients with CEA ratio>1 had poor prognosis, however the number was only 7 (5.7%). The 5-year survival rates of patients with other subgroup based on the CEA ratio (0.5 ≥ CEA ratio and 0.5 ≤ CEA ratio ≤ 1) was similar. Multivariate analysis revealed prognostic significance for the postoperative serum CEA level but not the CEA ratio.
  
  
  CONCLUSIONS
  For NSCLC patients with preoperative high serum CEA level, their postoperative serum CEA levels is a more significant prognostic factor than the post/preoperative serum CEA ratio.
authors.affiliation: Department of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan E-mail : mtomita@med.miyazaki-u.ac.jp.
authors.forename: Masaki
authors.initials: M
authors.lastname: Tomita
authors.forename: Takanori
authors.initials: T
authors.lastname: Ayabe
authors.forename: Eiichi
authors.initials: E
authors.lastname: Chosa
authors.forename: Kunihide
authors.initials: K
authors.lastname: Nakamura
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000401:mortality* / Q000601:surgery; D000077192:Adenocarcinoma of Lung; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000401:mortality* / Q000601:surgery; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000401:mortality* / Q000601:surgery; D008297:Male; D011184:Postoperative Period; D057234:Preoperative Period; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D002272:Carcinoembryonic Antigen