title: Morning blood pressure surge and target organ damage in newly diagnosed type 2 diabetic patients: a cross sectional study.
abstract: BACKGROUND
  Type 2 diabetic patients display significantly higher incidence of cardiovascular (CV) events including stroke compared to non-diabetics. Morning blood pressure surge (MBPS) and blunted systolic night-day (SND) ratio have been associated with CV events in hypertensive patients. No studies have evaluated MBPS in newly diagnosed diabetic patients or studied the association with vascular target organ damage at this early time point of the diabetes disease.
  
  
  METHODS
  Ambulatory blood pressure monitoring was performed in 100 patients with newly diagnosed type 2 diabetes and 100 age and sex matched controls. MBPS and SND-ratio were calculated. Markers of early vascular target organ damage included pulse wave velocity (PWV), white matter lesions (WML) on brain MRI, and urine albumin/creatinine ratio (UAE).
  
  
  RESULTS
  No significant differences in MBPS were found between diabetic patients and controls. Neither MBPS or SND-ratio were associated with PWV, UAE or WML in the diabetic group independently of age, gender and 24-h systolic blood pressure. 40.2 % of diabetic patients and 25.8 % of controls were classified as non-dippers (p = 0.03).
  
  
  CONCLUSIONS
  MBPS and SND-ratio are not associated with subclinical markers of vascular target organ damage in our study sample of newly diagnosed type 2 diabetic patients.
authors.affiliation: Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Nørrebrogade 44, DK-8000, Aarhus C, Denmark. JohanneLyhne@gmail.com.
authors.forename: Johanne M
authors.initials: JM
authors.lastname: Lyhne
authors.affiliation: Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Nørrebrogade 44, DK-8000, Aarhus C, Denmark. esben.laugesen@clin.au.dk.|Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. esben.laugesen@clin.au.dk.|The Danish Diabetes Academy, Odense University Hospital, Odense, Denmark. esben.laugesen@clin.au.dk.
authors.forename: Esben
authors.initials: E
authors.lastname: Laugesen
authors.affiliation: Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Nørrebrogade 44, DK-8000, Aarhus C, Denmark. pernillehoeyem@hotmail.com.
authors.forename: Pernille
authors.initials: P
authors.lastname: Høyem
authors.affiliation: Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Nørrebrogade 44, DK-8000, Aarhus C, Denmark. simon.cichosz@clin.au.dk.
authors.forename: Simon
authors.initials: S
authors.lastname: Cichosz
authors.affiliation: Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Nørrebrogade 44, DK-8000, Aarhus C, Denmark. jsc@clin.au.dk.
authors.forename: Jens S
authors.initials: JS
authors.lastname: Christiansen
authors.affiliation: Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Nørrebrogade 44, DK-8000, Aarhus C, Denmark. stk@dadlnet.dk.
authors.forename: Søren T
authors.initials: ST
authors.lastname: Knudsen
authors.affiliation: Medical department, Diagnostic Center, Regional Hospital Silkeborg, Silkeborg, Denmark. klavhans@rm.dk.
authors.forename: Klavs W
authors.initials: KW
authors.lastname: Hansen
authors.affiliation: Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Nørrebrogade 44, DK-8000, Aarhus C, Denmark. troels.krarup.hansen@clin.au.dk.
authors.forename: Troels K
authors.initials: TK
authors.lastname: Hansen
authors.affiliation: Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Nørrebrogade 44, DK-8000, Aarhus C, Denmark. d243205@dadlnet.dk.
authors.forename: Per L
authors.initials: PL
authors.lastname: Poulsen
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002318:Cardiovascular Diseases / Q000209:etiology*; D016022:Case-Control Studies; D002940:Circadian Rhythm / Q000502:physiology*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis; D003925:Diabetic Angiopathies / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors