title: Outcomes of endovascular treatment of basilar artery occlusion in the stent retriever era: a systematic review and meta-analysis.
abstract: BACKGROUND
  Stent retriever thrombectomy has recently been found to be effective for anterior circulation strokes, but its efficacy for basilar artery occlusion (BAO) is unclear.
  
  
  OBJECTIVE
  To carry out a systematic review and meta-analysis to analyze the available evidence for the use of stent retrievers for BAO.
  
  
  METHODS
  Two independent reviewers searched six databases for studies reporting outcomes following endovascular treatment for BAO.
  
  
  RESULTS
  A total of 17 articles (6 prospective and 11 retrospective) were included. The weighted mean age of patients was 67 years (range 59-82) and 59% were male. Thrombolytic drugs were administered intravenously and intra-arterially in 46% (range 0-88%) and 38% (range 0-90%) of patients, respectively. Weighted pooled estimates of successful recanalization (TICI 2b-3) and good outcome (modified Rankin Scale ≤2) were 80.0% (95% CI 70.7% to 88.0%; I2=80.28%; p<0.001) and 42.8% (95% CI 34.0% to 51.8%; I2=61.83%; p=0.002), respectively. Pooled mortality was 29.4% (95% CI 23.9% to 35.3%; I2=37.01%; p=0.087). Incidence of procedure-related complications and symptomatic hemorrhage was 10.0% (95% CI 3.7% to 18.3%; I2=61.05%; p=0.017) and 6.8% (95% CI 3.5% to 10.8%; I2=37.99%; p=0.08), respectively.
  
  
  CONCLUSIONS
  Stent retriever thrombectomy achieves a high rate of recanalization and functional independence while being relatively safe for patients with BAO. Future prospective studies with long-term follow-up are warranted.
authors.affiliation: NeuroSpine Surgery Research Group (NSURG), Sydney, New South Wales, Australia Faculty of Medicine, University of New South Wales (UNSW), Sydney, New South Wales, Australia Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Kevin
authors.initials: K
authors.lastname: Phan
authors.affiliation: NeuroSpine Surgery Research Group (NSURG), Sydney, New South Wales, Australia Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Steven
authors.initials: S
authors.lastname: Phan
authors.affiliation: Faculty of Medicine, University of New South Wales (UNSW), Sydney, New South Wales, Australia.
authors.forename: Ya Ruth
authors.initials: YR
authors.lastname: Huo
authors.affiliation: NeuroSpine Surgery Research Group (NSURG), Sydney, New South Wales, Australia Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Fangzhi
authors.initials: F
authors.lastname: Jia
authors.affiliation: Department of Neuroradiology, North Bristol NHS Trust, Bristol, UK.
authors.forename: Alex
authors.initials: A
authors.lastname: Mortimer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015607:Stents; D017131:Thrombectomy; D015912:Thrombolytic Therapy; D016896:Treatment Outcome; D014715:Vertebrobasilar Insufficiency / Q000601:surgery*
keywords: Device; Stent; Stroke; Thrombectomy; Thrombolysis