title: Fish Peroxiredoxins and Their Role in Immunity.
abstract: Peroxiredoxins (Prxs) are a family of antioxidant enzymes that protect cells from oxidative damage. In addition, Prxs may act as modulators of inflammation, protect against cell death and tumour progression, and facilitate tissue repair after damage. The most studied roles of Prx1 and Prx2 are immunological. Here we present a review on the effects of some immunostimulant treatments and bacterial, viral, or parasitic infections on the expression of fish Prxs at the gene and/or protein level, and point to their important role in immunity. The Prxs show antioxidant activity as well as a protective effect against infection. Some preliminary data are presented about the role of fish Prx1 and Prx2 in virus resistance although further studies are needed before the role of fish Prx in immunity can be definitively defined.
authors.affiliation: Centro Oceanográfico de Murcia, Instituto Español de Oceanografía (IEO), Carretera de la Azohía s/n, Puerto de Mazarrón, Murcia 30860, Spain. yulema.valero@mu.ieo.es.
authors.forename: Yulema
authors.initials: Y
authors.lastname: Valero
authors.affiliation: Fish Innate Immune System Group, Department of Cell Biology and Histology, Faculty of Biology, Campus Regional de Excelencia Internacional "Campus Mare Nostrum", University of Murcia, Murcia 30100, Spain. javimartinez12@hotmail.com.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Martínez-Morcillo
authors.affiliation: Fish Innate Immune System Group, Department of Cell Biology and Histology, Faculty of Biology, Campus Regional de Excelencia Internacional "Campus Mare Nostrum", University of Murcia, Murcia 30100, Spain. aesteban@um.es.
authors.forename: M Ángeles
authors.initials: MÁ
authors.lastname: Esteban
authors.affiliation: Centro Oceanográfico de Murcia, Instituto Español de Oceanografía (IEO), Carretera de la Azohía s/n, Puerto de Mazarrón, Murcia 30860, Spain. elena.chaves@mu.ieo.es.
authors.forename: Elena
authors.initials: E
authors.lastname: Chaves-Pozo
authors.affiliation: Fish Innate Immune System Group, Department of Cell Biology and Histology, Faculty of Biology, Campus Regional de Excelencia Internacional "Campus Mare Nostrum", University of Murcia, Murcia 30100, Spain. alcuesta@um.es.
authors.forename: Alberto
authors.initials: A
authors.lastname: Cuesta
keywords: antioxidant enzymes; fish; immunity; natural killer enhancement factor; peroxiredoxins; virus