title: Computational study of the fluid-dynamics in carotids before and after endarterectomy.
abstract: In this work, we provide a computational study of the effects of carotid endarterectomy (CEA) on the fluid-dynamics at internal carotid bifurcations. We perform numerical simulations in real geometries of the same patients before and after CEA, using patient-specific boundary data obtained by Echo-Color Doppler measurements. We analyze four patients with a primary closure and other four where a patch was used to close arteriotomies. The results show that (i) CEA is able to restore physiological fluid-dynamic conditions; (ii) among the post-operative cases, the presence of patch leads to local hemodynamic conditions which might imply a higher risk of restenosis in comparison with the cases without patch.
authors.affiliation: MOX, Dipartimento di Matematica, Politecnico di Milano, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Guerciotti
authors.affiliation: MOX, Dipartimento di Matematica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy. Electronic address: christian.vergara@polimi.it.
authors.forename: Christian
authors.initials: C
authors.lastname: Vergara
authors.affiliation: IDSIA, USI/SUPSI, Manno, Switzerland.
authors.forename: Laura
authors.initials: L
authors.lastname: Azzimonti
authors.affiliation: Radiology Unit, Fondazione I.R.C.C.S. Ca׳ Granda, Ospedale Maggiore Policlinico di Milano, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Forzenigo
authors.affiliation: Operative Unit of Vascular Surgery, Fondazione I.R.C.C.S. Ca׳ Granda Ospedale Maggiore Policlinico di Milano, Italy; Department of Clinical Sciences and Community, Università di Milano, Italy.
authors.forename: Adelaide
authors.initials: A
authors.lastname: Buora
authors.affiliation: Radiology Unit, Fondazione I.R.C.C.S. Ca׳ Granda, Ospedale Maggiore Policlinico di Milano, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Biondetti
authors.affiliation: Operative Unit of Vascular Surgery, Fondazione I.R.C.C.S. Ca׳ Granda Ospedale Maggiore Policlinico di Milano, Italy; Department of Clinical Sciences and Community, Università di Milano, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Domanin
mesh_terms: D001807:Blood Vessel Prosthesis; D002343:Carotid Artery, Internal / Q000601:surgery*; D016893:Carotid Stenosis / Q000503:physiopathology*; D003198:Computer Simulation; D023903:Coronary Restenosis / Q000503:physiopathology*; D016894:Endarterectomy, Carotid; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery; D006439:Hemodynamics; D006801:Humans; D057446:Hydrodynamics; D008297:Male; D008962:Models, Theoretical; D011093:Polyethylene Terephthalates; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler
chemical_list: D011093:Polyethylene Terephthalates
keywords: CFD; Carotids; Endarterectomy; Restenosis