title: Effect of Chaenomeles sinensis Extract on Choline Acetyltransferase Activity and Trimethyltin-Induced Learning and Memory Impairment in Mice.
abstract: The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenomeles sinensis Koehne showed the highest ChAT-activating effect in vitro in an assay that used human neuroblastoma cells and [(14)C]acetyl-CoA. The active compound was speculated to be stearic acid methyl ester (SAME). In an in vivo experiment, C. sinensis extract and SAME improved trimethyltin (TMT)-induced deficits in learning and memory in mice as assessed by a Y-maze behavioral test and a passive avoidance test. The C. sinensis extract might attenuate the TMT-induced brain disorder. This study suggests that SAME from C. sinensis might be useful in the treatment of Alzheimer's disease.
authors.affiliation: Department of Food and Biotechnology, Korea University.
authors.forename: Yoon Kyung
authors.initials: YK
authors.lastname: Kwon
authors.forename: Soo Jung
authors.initials: SJ
authors.lastname: Choi
authors.forename: Cho Rong
authors.initials: CR
authors.lastname: Kim
authors.forename: Jae Kyeom
authors.initials: JK
authors.lastname: Kim
authors.forename: Hye Kyung
authors.initials: HK
authors.lastname: Kim
authors.forename: Jong Hun
authors.initials: JH
authors.lastname: Choi
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Song
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Kim
authors.forename: Gwi Gun
authors.initials: GG
authors.lastname: Park
authors.forename: Cheung-Seog
authors.initials: CS
authors.lastname: Park
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Shin
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D008813:Mice, Inbred ICR; D009447:Neuroblastoma / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D027824:Rosaceae / Q000737:chemistry*; D014298:Trimethyltin Compounds / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D014298:Trimethyltin Compounds; C046488:trimethyltin; D002795:Choline O-Acetyltransferase