title: The Acute to Chronic Pain Transition: Can Chronic Pain Be Prevented?
abstract: Chronic postsurgical pain (CPSP) is a distressing disease process that can lead to long-term disability, reduced quality of life, and increased health care spending. Although the exact mechanism of development of CPSP is unknown, nerve injury and inflammation may lead to peripheral and central sensitization. Given the complexity of the disease process, no novel treatment has been identified. The preoperative use of multimodal analgesia has been shown to decrease acute postoperative pain, but it has no proven efficacy in preventing development of CPSP.
authors.affiliation: Department of Anesthesiology, Thomas Jefferson University, Gibbon Building, Suite 8280, 111 South 11th Street, Philadelphia, PA 19107, USA. Electronic address: John-Paul.Pozek@jefferson.edu.
authors.forename: John-Paul J
authors.initials: JP
authors.lastname: Pozek
authors.affiliation: Department of Anesthesiology, Thomas Jefferson University, Gibbon Building, Suite 8490, 111 South 11th Street, Philadelphia, PA 19107, USA.
authors.forename: David
authors.initials: D
authors.lastname: Beausang
authors.affiliation: Department of Anesthesiology, Thomas Jefferson University, Gibbon Building, Suite 8280, 111 South 11th Street, Philadelphia, PA 19107, USA.
authors.forename: Jaime L
authors.initials: JL
authors.lastname: Baratta
authors.affiliation: Department of Anesthesiology, Thomas Jefferson University, Gibbon Building, Suite 8490, 111 South 11th Street, Philadelphia, PA 19107, USA.
authors.forename: Eugene R
authors.initials: ER
authors.lastname: Viscusi
mesh_terms: D059787:Acute Pain / Q000209:etiology / Q000628:therapy*; D059350:Chronic Pain / Q000209:etiology / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods*; D006801:Humans; D059408:Pain Management / Q000379:methods*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000209:etiology / Q000628:therapy*; D011788:Quality of Life
keywords: Central sensitization; Chronic postsurgical pain; Gabapentinoids; Ketamine; Neuropathic pain; Peripheral sensitization; Quantitative sensory testing