title: Safety and Efficacy of Rice Bran Supercritical CO2 Extract for Hair Growth in Androgenic Alopecia: A 16-Week Double-Blind Randomized Controlled Trial.
abstract: We conducted a 16-week double-blind randomized controlled single-center trial to evaluate the safety and efficacy of dermal rice bran supercritical CO2 extract (RB-SCE) in the treatment of androgenic alopecia. Fifty alopecia patients were randomly assigned to the experimental and placebo groups. The experimental group received a dermal application of 0.5% RB-SCE (8 mL/d) to the head skin for 16 weeks while the control group received a dermal application of placebo. Changes in hair count, diameter, and density were evaluated with a Folliscope(®). Patient satisfaction was evaluated via questionnaire and clinical photographs were rated by dermatologists. The results showed that RB-SCE significantly increased hair density and hair diameter in male subjects. Patient satisfaction and the evaluation of photographs by dermatologists also confirmed the effectiveness of RB-SCE in the treatment of alopecia. No adverse reactions related to RB-SCE were reported. Therefore, RB-SCE shows promise for use in functional cosmetics and pharmaceuticals.
authors.affiliation: Major in Food Biotechnology, Division of Bioindustry, College of Medical and Life Sciences, Silla University.
authors.forename: Jae-Suk
authors.initials: JS
authors.lastname: Choi
authors.forename: Jae Beom
authors.initials: JB
authors.lastname: Park
authors.forename: Woi-Sook
authors.initials: WS
authors.lastname: Moon
authors.forename: Jin-Nam
authors.initials: JN
authors.lastname: Moon
authors.forename: Sang Wook
authors.initials: SW
authors.lastname: Son
authors.forename: Mi-Ryung
authors.initials: MR
authors.lastname: Kim
mesh_terms: D000328:Adult; D000505:Alopecia / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006197:Hair / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D008297:Male; D008875:Middle Aged; D012275:Oryza; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D012639:Seeds / Q000737:chemistry*
chemical_list: D010936:Plant Extracts