title: Differential Functional Connectivity Correlates of Cerebrospinal Fluid Biomarkers in Dementia of the Alzheimer's Type.
abstract: BACKGROUND
  Alzheimer's disease (AD) is characterized by two cardinal pathologies, which have different topological distributions. The differential anatomical distributions of these pathologies raise the possibility that they exert differential effects on brain networks.
  
  
  OBJECTIVE
  To investigate whether cerebrospinal fluid (CSF) biomarkers of the cardinal pathologies have differential relationships with functional connectivity networks in patients with dementia of the Alzheimer's type (DAT).
  
  
  METHODS
  Thirty-nine participants underwent CSF sampling and resting-state functional magnetic resonance imaging. Functional connectivity networks were computed for each participant. CSF biomarker levels of p-tau and amyloid-β (Aβ) were regressed onto these networks to identify subnetworks associated with each biomarker.
  
  
  RESULTS
  A subnetwork associated with tau-related pathology was identified with its hub in the right anterior entorhinal cortex. A separate subnetwork associated with Aβ with its hub in the right dorsal anterior cingulate cortex was identified.
  
  
  CONCLUSIONS
  These results demonstrate the differential effects of AD biomarkers on functional connectivity networks, supporting a possible division of labour between the cardinal pathologies.
authors.affiliation: Melbourne Brain Centre, Department of Medicine, The University of Melbourne, Melbourne, Vic., Australia.
authors.forename: Charles B
authors.initials: CB
authors.lastname: Malpas
authors.forename: Michael M
authors.initials: MM
authors.lastname: Saling
authors.forename: Dennis
authors.initials: D
authors.lastname: Velakoulis
authors.forename: Patricia
authors.initials: P
authors.lastname: Desmond
authors.forename: Terence J
authors.initials: TJ
authors.lastname: O'Brien
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D010766:Phosphorylation; D012044:Regression Analysis; D012146:Rest; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; C054369:MAPT protein, human; D016875:tau Proteins