title: Intestinal inflammation and pain management.
abstract: Intestinal inflammation results in the production of inflammatory pain-inducing mediators that may directly activate colon sensory neurons. Endogenous opioids produced by mucosal effector CD4(+) T lymphocytes identified as colitogenic may paradoxically counterbalance the local pro-algesic effect of inflammatory mediators by acting on opioid receptors expressed on sensory nerve endings. The review will focus on the endogenous immune-mediated regulation of visceral inflammatory pain, current pain treatments in inflammatory bowel diseases and prospectives on new opioid therapeutic opportunities to alleviate pain but avoiding common centrally-mediated side effects.
authors.affiliation: INSERM, U1043, Toulouse F-31300, France; CNRS, U5282, Toulouse F-31300, France; Université de Toulouse, UPS, Toulouse F-31300, France.
authors.forename: Lilian
authors.initials: L
authors.lastname: Basso
authors.affiliation: INSERM, U913, Nantes F-44093, France; Université de Nantes, Institut des Maladies de l'Appareil Digestif, Nantes F-44093, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bourreille
authors.affiliation: INSERM, U1043, Toulouse F-31300, France; CNRS, U5282, Toulouse F-31300, France; Université de Toulouse, UPS, Toulouse F-31300, France. Electronic address: gilles.dietrich@inserm.fr.
authors.forename: Gilles
authors.initials: G
authors.lastname: Dietrich
mesh_terms: D000701:Analgesics, Opioid / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D018448:Models, Immunological; D018847:Opioid Peptides / Q000378:metabolism / Q000627:therapeutic use*; D059408:Pain Management / Q000379:methods*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D059265:Visceral Pain / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology
chemical_list: D000701:Analgesics, Opioid; D018847:Opioid Peptides