title: Polydioxanone-based bio-materials for tissue engineering and drug/gene delivery applications.
abstract: Since the commercialization of polydioxanone (PDX) as a biodegradable monofilament suture by Ethicon in 1981, the polymer has received only limited interest until recently. The limitations of polylactide-co-glycolide (PLGA) coupled with the growing need for materials with enhanced features and the advent of new fabrication techniques such as electrospinning have revived interest for PDX in medical devices, tissue engineering and drug delivery applications. Electrospun PDX mats show comparable mechanical properties as the major structural components of native vascular extracellular matrix (ECM) i.e. collagen and elastin. In addition, PDX's unique shape memory property provides rebound and kink resistance when fabricated into vascular conduits. The synthesis of methyl dioxanone (MeDX) monomer and copolymers of dioxanone (DX) and MeDX have opened up new perspectives for poly(ester-ether)s, enabling the design of the next generation of tissue engineering scaffolds for application in regenerating such tissues as arteries, peripheral nerve and bone. Tailoring of polymer properties and their formulation as nanoparticles, nanomicelles or nanofibers have brought along important developments in the area of controlled drug or gene delivery. This paper reviews the synthesis of PDX and its copolymers and provides for the first time an exhaustive account of its applications in the (bio)medical field with focus on tissue engineering and drug/gene delivery.
authors.affiliation: ANDI Centre of Excellence for Biomedical and Biomaterials Research, MSIRI Building, University of Mauritius, Réduit, Mauritius.
authors.forename: Nowsheen
authors.initials: N
authors.lastname: Goonoo
authors.affiliation: ANDI Centre of Excellence for Biomedical and Biomaterials Research, MSIRI Building, University of Mauritius, Réduit, Mauritius.
authors.forename: Roubeena
authors.initials: R
authors.lastname: Jeetah
authors.affiliation: ANDI Centre of Excellence for Biomedical and Biomaterials Research, MSIRI Building, University of Mauritius, Réduit, Mauritius.
authors.forename: Archana
authors.initials: A
authors.lastname: Bhaw-Luximon
authors.affiliation: ANDI Centre of Excellence for Biomedical and Biomaterials Research, MSIRI Building, University of Mauritius, Réduit, Mauritius. Electronic address: djhurry@uom.ac.mu.
authors.forename: Dhanjay
authors.initials: D
authors.lastname: Jhurry
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D008823:Micelles; D057139:Nanofibers / Q000737:chemistry; D016687:Polydioxanone / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D008823:Micelles; D016687:Polydioxanone
keywords: Biodegradable scaffolds; Biomaterials; Drug delivery systems; Poly(ester-ether)s; Polydioxanone; Tissue engineering