title: [Anaplastic large-cell lymphoma CD30(+) ALK(+)].
abstract: We present a case of primary systemic anaplastic large-cell lymphoma, which manifested itself through skin involvement in a 32-year-old man. Only the third histological investigation with immunophenotyping resulted in the correct diagnosis of CD30(+) ALK(+) anaplastic large cell lymphoma. After combined chemotherapy and adjuvant radiotherapy, complete remission of the disease was achieved and one year after completion of therapy no relapse occurred. The diagnostic pitfalls and therapeutic options are discussed.
authors.affiliation: Klinik für Dermatologie und Venerologie der Medizinischen Fakultät, Comenius Universität, Mickiewiczova 13, 813 69, Bratislava, Slowakei. luciaslov@yahoo.com.
authors.forename: L
authors.initials: L
authors.lastname: Kollarikova
authors.affiliation: Klinik für Dermatologie und Venerologie der Medizinischen Fakultät, Comenius Universität, Mickiewiczova 13, 813 69, Bratislava, Slowakei.
authors.forename: M
authors.initials: M
authors.lastname: Heizerova
authors.affiliation: Klinik für Dermatologie und Venerologie der Medizinischen Fakultät, Comenius Universität, Mickiewiczova 13, 813 69, Bratislava, Slowakei.
authors.forename: M
authors.initials: M
authors.lastname: Simaljakova
mesh_terms: D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D053285:CD30 Ligand / Q000378:metabolism*; D059248:Chemoradiotherapy / Q000379:methods; D003937:Diagnosis, Differential; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D008297:Male; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D053285:CD30 Ligand; C505774:TNFSF8 protein, human; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
keywords: Chemotherapy; Histology; Immunophenotyping; Primary systemic lymphoma; Radiotherapy