title: Endoscopic Endonasal Management of Skull Base Chordomas: Surgical Technique, Nuances, and Pitfalls.
abstract: Chordoma is a rare primary bone tumor derived from transformed notochord remnants. It has a local aggressive behavior and high recurrence rates. Treatment of skull base chordomas is complex and challenging. Control of the disease relies mainly on surgical excision of the tumor, sometimes followed by high-dose radiation therapy. The main surgical goal is to achieve maximal tumor removal with minimal morbidity. Development of the expanded endoscopic endonasal approach has improved surgical and prognostic results of skull base chordomas. This article highlights important aspects of approach selection, technique, and nuances of surgical management of this tumor.
authors.affiliation: São Paulo Skull Base Center, Rua Afonso Brás, 525, cj. 13, São Paulo 04511-011, Brazil; São Paulo ENT Center, Edmundo Vasconcelos Hospital, Rua Afonso Brás, 525, cj. 13, São Paulo 04511-011, Brazil.
authors.forename: João
authors.initials: J
authors.lastname: Mangussi-Gomes
authors.affiliation: São Paulo Skull Base Center, Rua Afonso Brás, 525, cj. 13, São Paulo 04511-011, Brazil; DFVneuro Neurosurgical Group, Rua Dona Adma Jafet, 74, cj.121, São Paulo 01308-050, Brazil.
authors.forename: André
authors.initials: A
authors.lastname: Beer-Furlan
authors.affiliation: São Paulo Skull Base Center, Rua Afonso Brás, 525, cj. 13, São Paulo 04511-011, Brazil; São Paulo ENT Center, Edmundo Vasconcelos Hospital, Rua Afonso Brás, 525, cj. 13, São Paulo 04511-011, Brazil.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Balsalobre
authors.affiliation: São Paulo Skull Base Center, Rua Afonso Brás, 525, cj. 13, São Paulo 04511-011, Brazil; DFVneuro Neurosurgical Group, Rua Dona Adma Jafet, 74, cj.121, São Paulo 01308-050, Brazil.
authors.forename: Eduardo A S
authors.initials: EA
authors.lastname: Vellutini
authors.affiliation: São Paulo Skull Base Center, Rua Afonso Brás, 525, cj. 13, São Paulo 04511-011, Brazil; São Paulo ENT Center, Edmundo Vasconcelos Hospital, Rua Afonso Brás, 525, cj. 13, São Paulo 04511-011, Brazil. Electronic address: astamm@terra.com.br.
authors.forename: Aldo C
authors.initials: AC
authors.lastname: Stamm
mesh_terms: D002817:Chordoma / Q000473:pathology* / Q000601:surgery*; D004724:Endoscopy / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009666:Nose / Q000601:surgery; D011183:Postoperative Complications; D011379:Prognosis; D019651:Plastic Surgery Procedures / Q000379:methods*; D019292:Skull Base Neoplasms / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Chordoma; Clival chordoma; Endoscopic endonasal approach; Endoscopy; Skull base chordoma