title: Renal anomalies in patients with turner syndrome: Is scintigraphy superior to ultrasound?
abstract: Renal anomalies are present in up to 30% of patients with Turner syndrome (TS). Renal ultrasound (U/S) detects anatomical renal anomalies only while renal scintigraphy detects anomalies, detects early renal malfunction, and estimates glomerular filtration rate (GFR). Thus, we aimed to assess frequency of renal abnormalities detected by scintigraphy in comparison to renal U/S in TS patients. Ninety TS patients were subjected to auxological assessment, measurement of serum creatinine; and renal U/S and scintigraphy. Renal U/S detected renal anomalies in 22.22% of patients versus 17.78 % detected by scintigraphy (P = 0.035). Scintigraphy detected renal functional abnormalities in 44.44% of patients in the form of subnormal total GFR, abnormal renogram curve pattern, improper tracer handling and perfusion; and difference in split renal function >10% between both kidneys. Patients with a 45,X karyotype had more renal functional abnormalities (56%) than those with mosaic karyotype (33.33%), P = 0.04. In conclusion, renal scintigraphy is not superior to U/S in detection of renal anomalies but is a reliable method for early detection of renal malfunction in TS patients especially those with 45,X to ensure early management to offer a better quality of life.
authors.affiliation: Departments of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Rasha T
authors.initials: RT
authors.lastname: Hamza
authors.affiliation: Departments of Radiodiagnosis and Diagnostic Nuclear Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Mennatallah H
authors.initials: MH
authors.lastname: Shalaby
authors.affiliation: Departments of Radiodiagnosis and Diagnostic Nuclear Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Laith S
authors.initials: LS
authors.lastname: Hamed
authors.affiliation: Departments of Radiodiagnosis and Diagnostic Nuclear Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Dunya B A
authors.initials: DBA
authors.lastname: Abdulla
authors.affiliation: Departments of Radiodiagnosis and Diagnostic Nuclear Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Sahar M
authors.initials: SM
authors.lastname: Elfekky
authors.affiliation: Departments of Radiodiagnosis and Diagnostic Nuclear Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Omar M
authors.initials: OM
authors.lastname: Sultan
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007621:Karyotyping / Q000379:methods; D007674:Kidney Diseases / Q000175:diagnosis* / Q000209:etiology; D007677:Kidney Function Tests; D011379:Prognosis; D011788:Quality of Life; D011877:Radionuclide Imaging / Q000379:methods*; D014424:Turner Syndrome / Q000150:complications*; D014463:Ultrasonography / Q000379:methods*; D055815:Young Adult
keywords: anomalies; renal; scintigraphy; turner syndrome; ultrasound