title: Effect of Sucrose Analgesia, for Repeated Painful Procedures, on Short-term Neurobehavioral Outcome of Preterm Neonates: A Randomized Controlled Trial.
abstract: BACKGROUND
  Safety of oral sucrose, commonly used procedural analgesic in neonates, is questioned.
  
  
  OBJECTIVE
  To evaluate the effect of sucrose analgesia, for repeated painful procedures, on short-term neurobehavioral outcome of preterm neonates.
  
  
  METHODS
  Stable preterm neonates were randomized to receive either sucrose or distilled water orally, for every potentially painful procedure during the first 7 days after enrollment. Neurodevelopmental status at 40 weeks postconceptional age (PCA) measured using the domains of Neurobehavioral Assessment of Preterm Infants scale.
  
  
  RESULTS
  A total of 93 newborns were analyzed. The baseline characteristics of the groups were comparable. No statistically significant difference was observed in the assessment at 40 weeks PCA, among the groups. Use of sucrose analgesia, for repeated painful procedures on newborns, does not lead to any significant difference in the short-term neurobehavioral outcome.
authors.affiliation: Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India 110001.
authors.forename: Shreshtha
authors.initials: S
authors.lastname: Banga
authors.affiliation: Department of Neonatology, Lady Hardinge Medical College, New Delhi, India 110001.
authors.forename: Vikram
authors.initials: V
authors.lastname: Datta
authors.affiliation: Department of Pharmacology, Lady Hardinge Medical College, New Delhi, India 110001.
authors.forename: Harmeet Singh
authors.initials: HS
authors.lastname: Rehan
authors.affiliation: Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India 110001 drbhanu04@gmail.com.
authors.forename: Bhanu Kiran
authors.initials: BK
authors.lastname: Bhakhri
mesh_terms: D000698:Analgesia / Q000009:adverse effects*; D000700:Analgesics / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D008722:Methods; D009460:Neurologic Examination; D017063:Outcome Assessment, Health Care; D010146:Pain / Q000503:physiopathology / Q000517:prevention & control*; D059408:Pain Management / Q000379:methods*; D010147:Pain Measurement; D013395:Sucrose / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000700:Analgesics; D013395:Sucrose
keywords: neurobehavior; procedural pain; sucrose analgesia