title: Characterization of omega-3 tablets.
abstract: Omega-3 nutraceuticals are extensively used as health supplements worldwide. Various administration forms for delivery of omega-3 are available. However, the niche omega-3 tablets have so far remained unexplored. In this work tablets containing 25-40% (w/w) omega-3 oil as triglycerides or ethyl esters were prepared utilizing a direct compaction grade powder with β-cyclodextrin as encapsulating agent. It was found that powders with up to 35% (w/w) triglyceride oil and 30% (w/w) ethyl ester oil, respectively, can be directly compressed into tablets of excellent quality. Physical properties of omega-3 containing powders and tablets are described. The powder X-ray diffractograms of the powders and crushed tablets show evidence of the formation of new crystalline phases not present in β-cyclodextrin. In addition, (1)H NMR data suggest that the ethyl esters form inclusion complexes with β-cyclodextrin. Compaction of other, commercially available, omega-3 powders was performed as a comparison and deemed unsuccessful.
authors.affiliation: Omegatri AS, P.O. Box 4849 Nydalen, 0422 Oslo, Norway; School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway. Electronic address: tina.lien.vestland@omegatri.no.
authors.forename: Tina Lien
authors.initials: TL
authors.lastname: Vestland
authors.affiliation: Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, 0315 Oslo, Norway.
authors.forename: Øyvind
authors.initials: Ø
authors.lastname: Jacobsen
authors.affiliation: School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway.
authors.forename: Sverre Arne
authors.initials: SA
authors.lastname: Sande
authors.affiliation: Tåsen Terrasse 4A, 0873 Oslo, Norway.
authors.forename: Astrid Hilde
authors.initials: AH
authors.lastname: Myrset
authors.affiliation: Omegatri AS, P.O. Box 4849 Nydalen, 0422 Oslo, Norway; School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway.
authors.forename: Jo
authors.initials: J
authors.lastname: Klaveness
mesh_terms: D019587:Dietary Supplements / Q000032:analysis*; D015525:Fatty Acids, Omega-3 / Q000032:analysis*; D011208:Powders / Q000737:chemistry; D013607:Tablets / Q000737:chemistry; D014280:Triglycerides / Q000032:analysis; D047392:beta-Cyclodextrins / Q000032:analysis
chemical_list: D015525:Fatty Acids, Omega-3; D011208:Powders; D013607:Tablets; D014280:Triglycerides; D047392:beta-Cyclodextrins; C031215:betadex
keywords: Cyclodextrin; DHA; EPA; Fish oil; Omega-3; Powder; Tablets