title: Duodenal gangliocytic paraganglioma: report of two cases and review of literature.
abstract: We report two cases of Gangliocytic paraganglioma (GP), one of which was accompanied by lymph node metastasis. Histologically, the tumor was composed of three morphologically distinct cell populations: spindle cells, ganglion-like cells and epithelioid cells. The epithelioid cells were positive for cytokeratin (AE1/AE3), synaptophysin (Syn), chromogranin A (CgA), CD56 and progesterone receptor (PR). Ganglion-like cell types showed positive reactivity for Syn and CD56. In contrast, the spindle-shaped cells showed positive reactivity for S-100. The patient with lymph node metastasis has a good prognosis. Nonetheless, close surveillance is still necessary for patients with GP because a few cases of GP with regional lymph node metastasis and even distant metastasis have been published, including a malignant case of GP showing a lethal course.
authors.affiliation: Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University Zhejiang, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University Zhejiang, China.
authors.forename: Yinying
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University Zhejiang, China.
authors.forename: Han
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University Zhejiang, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University Zhejiang, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University Zhejiang, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Sun
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D004379:Duodenal Neoplasms / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010235:Paraganglioma / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: CD117; Gangliocytic paraganglioma; chromogranin A; synaptophysin