title: Comparative Genomics and Evolutionary Modularity of Prokaryotes.
abstract: The soaring number of high-quality genomic sequences has ushered in the era of post-genomic research where our understanding of organisms has dramatically shifted towards defining the function of genes within their larger biological contexts. As a result, novel high-throughput experimental technologies are being increasingly employed to uncover physical and functional associations of genes and proteins in complex biological processes. Through the construction and analysis of physical, genetic and metabolic networks generated for the model organisms, such as Escherichia coli, organizational principles of the genome have been deduced, such as modularity, which has important implications toward understanding prokaryotic evolution and adaptation to novel lifestyles.
authors.affiliation: Department of Molecular Structure and Function, The Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, 686 Bay St. Rm 21-9830, Toronto, ON, Canada, M5G 0A4. ceda.bundalovic-torma@sickkids.ca.
authors.forename: Cedoljub
authors.initials: C
authors.lastname: Bundalovic-Torma
authors.affiliation: Department of Molecular Structure and Function, The Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, 686 Bay St. Rm 20-9709, Toronto, ON, Canada, M5G 0A4. jparkin@sickkids.ca.
authors.forename: John
authors.initials: J
authors.lastname: Parkinson
mesh_terms: D001419:Bacteria / Q000235:genetics*; D005075:Biological Evolution; D023281:Genomics; D057166:High-Throughput Screening Assays
keywords: Comparative genomics; Genomic-context; High-throughput interaction screening; Modularity; Network biology; Prokaryotic evolution