title: Esophageal Candidiasis as the Initial Manifestation of Acute Myeloid Leukemia.
abstract: A 47-year-old woman presented with persistent dysphagia. A gastroendoscopy revealed massive esophageal candidiasis, and oral miconazole was prescribed. Three weeks later, she returned to our hospital without symptomatic improvement. She was febrile, and blood tests showed leukocytosis (137,150 /μL, blast 85%), anemia and thrombocytopenia. She was diagnosed with acute myeloid leukemia (AML). She received chemotherapy and antimicrobial agents. During the recovery from the nadir, bilateral ocular candidiasis was detected, suggesting the presence of preceding candidemia. Thus, esophageal candidiasis can be an initial manifestation of AML. Thorough examination to detect systemic candidiasis is strongly recommended when neutropenic patients exhibit local candidiasis prior to chemotherapy.
authors.affiliation: Department of Hematology, Japan Community Healthcare Organization (JCHO) Tokyo Yamate Medical Center, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Komeno
authors.forename: Hideki
authors.initials: H
authors.lastname: Uryu
authors.forename: Yuko
authors.initials: Y
authors.lastname: Iwata
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Hatada
authors.forename: Jumpei
authors.initials: J
authors.lastname: Sakamoto
authors.forename: Kuniko
authors.initials: K
authors.lastname: Iihara
authors.forename: Tomiko
authors.initials: T
authors.lastname: Ryu
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000175:diagnosis* / Q000382:microbiology*; D003937:Diagnosis, Differential; D004941:Esophagitis / Q000175:diagnosis* / Q000382:microbiology*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy; D007964:Leukocytosis / Q000382:microbiology; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents