title: The mechanism for microsporidian parasite suppression of the hindgut bacteria of the migratory locust Locusta migratoria manilensis.
abstract: Locusts aggregate into bands of nymphs and swarms of adults that can pose a major threat to crop. Previous studies have shown that infection by the microsporidian parasite Paranosema locustae prevents locust aggregation behavior and we show that gut bacteria, which produce components of locust aggregation pheromones, are substantially reduced in locusts infected with P. locustae. We found that P. locustae could reduce the diversity, abundance and community composition of Locusta migratoria's gut bacteria. The parasite infection was also shown to interrupt the peroxidase activity of locust hindgut. Genome-wide expression analysis showed that the parasite infection suppressed peroxidase mRNA relative expression of locust hindgut, but had no effects on attacin expression and superoxide dismutase at 16 d post-inoculation with 20,000 P. locustae spores. Our findings reveal the mechanisms by which P. locustae impairs bacterial diversity and community structure of Locusta migratoria's gut bacteria.
authors.affiliation: Department of Entomology, China Agricultural University, Beijing, China.|Department of Entomology, China Agricultural University, Beijing, China.
authors.forename: Shu-Qian
authors.initials: SQ
authors.lastname: Tan
authors.affiliation: Department of Entomology, China Agricultural University, Beijing, China.|Department of Entomology, China Agricultural University, Beijing, China.
authors.forename: Kai-Qi
authors.initials: KQ
authors.lastname: Zhang
authors.affiliation: Department of Entomology, China Agricultural University, Beijing, China.|Department of Entomology, China Agricultural University, Beijing, China.
authors.forename: Hong-Xing
authors.initials: HX
authors.lastname: Chen
authors.affiliation: Department of Entomology, China Agricultural University, Beijing, China.|Department of Entomology, China Agricultural University, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Ge
authors.affiliation: College of Life Science, Xinjiang Normal University, Urumchi, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Ji
authors.affiliation: Department of Entomology, China Agricultural University, Beijing, China.|Department of Entomology, China Agricultural University, Beijing, China.
authors.forename: Wang-Peng
authors.initials: WP
authors.lastname: Shi
mesh_terms: D000818:Animals; D000898:Antibiosis; D001419:Bacteria / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D001522:Behavior, Animal; D044822:Biodiversity; D061046:Biological Control Agents / Q000494:pharmacology; D000069196:Gastrointestinal Microbiome / Q000187:drug effects* / Q000502:physiology; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions; D019476:Insect Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D048188:Locusta migratoria / Q000235:genetics / Q000378:metabolism / Q000382:microbiology*; D016814:Microsporidia / Q000472:pathogenicity* / Q000502:physiology; D009758:Nymph / Q000235:genetics / Q000378:metabolism / Q000382:microbiology; D009195:Peroxidase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D010675:Pheromones / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D010802:Phylogeny; D013172:Spores, Fungal / Q000472:pathogenicity* / Q000502:physiology
chemical_list: D061046:Biological Control Agents; D019476:Insect Proteins; D010675:Pheromones; C039711:attacin antibacterial protein, insect; D009195:Peroxidase