title: Modulation of brain network parameters associated with subclinical psychotic symptoms.
abstract: OBJECTIVE
  Static deficits in small-world properties of brain networks have been described in clinical psychosis, but task-related modulation of network properties has been scarcely studied. Our aim was to assess the modulation of those properties and its association with subclinical psychosis and cognition in the general population.
  
  
  METHODS
  Closeness centrality and small-worldness were compared between pre-stimulus baseline and response windows of an odd-ball task in 200 healthy individuals. The correlation between modulation of network parameters and clinical (scores in the Community Assessment of Psychological Experiences) and cognitive measures (performance in the dimensions included in the Brief Assessment of Cognition in Schizophrenia battery) was analyzed, as well as between these measures and the corresponding network parameters during baseline and response windows during task performance.
  
  
  RESULTS
  In the theta band, closeness centrality decreased and small-worldness increased in the response window. Centrality and small-worldness modulation were, respectively, directly and inversely associated with subclinical symptoms.
  
  
  CONCLUSIONS
  A widespread modulation of network properties in theta band was observed, with a transient increase of small-worldness during the response window, compatible with a transiently more integrated cortical activity associated to cognition. This supports the relevance of electroencephalography to study of normal and altered cognition and its substrates. A relative deficit in the ability to reorganize brain networks may contribute to subclinical psychotic symptoms.
authors.affiliation: Psychiatry Service, University Hospital of Palencia, Palencia, Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: Martin-Santiago
authors.affiliation: Biomedical Engineering Group, University of Valladolid, Valladolid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Gomez-Pilar
authors.affiliation: Psychiatry Department, School of Medicine, University of Valladolid, Valladolid, Spain.
authors.forename: Alba
authors.initials: A
authors.lastname: Lubeiro
authors.affiliation: Neurophysiology Service, University Hospital of Valladolid, Valladolid, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Ayuso
authors.affiliation: Biomedical Engineering Group, University of Valladolid, Valladolid, Spain; Mathematics Research Institute (IMUVA), University of Valladolid, Valladolid, Spain; Neuroscience Institute of Castilla y León (INCYL), University of Salamanca, Salamanca, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Poza
authors.affiliation: Biomedical Engineering Group, University of Valladolid, Valladolid, Spain; Mathematics Research Institute (IMUVA), University of Valladolid, Valladolid, Spain; Neuroscience Institute of Castilla y León (INCYL), University of Salamanca, Salamanca, Spain.
authors.forename: Roberto
authors.initials: R
authors.lastname: Hornero
authors.affiliation: Neuroscience Department, University of the Basque Country, Leioa, Spain; Psychiatry Service, University Hospital of Alava, Vitoria, Spain.
authors.forename: Myriam
authors.initials: M
authors.lastname: Fernandez
authors.affiliation: Neuroscience Department, University of the Basque Country, Leioa, Spain; Psychiatry Service, University Hospital of Alava, Vitoria, Spain.
authors.forename: Sonia Ruiz
authors.initials: SR
authors.lastname: de Azua
authors.affiliation: Neuroscience Department, University of the Basque Country, Leioa, Spain; Psychiatry Service, University Hospital of Alava, Vitoria, Spain.
authors.forename: Cesar
authors.initials: C
authors.lastname: Valcarcel
authors.affiliation: Psychiatry Department, School of Medicine, University of Valladolid, Valladolid, Spain; Neuroscience Institute of Castilla y León (INCYL), University of Salamanca, Salamanca, Spain; Psychiatry Service, University Hospital of Valladolid, Valladolid, Spain. Electronic address: vicente.molina@uva.es.
authors.forename: Vicente
authors.initials: V
authors.lastname: Molina
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D003071:Cognition / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D011618:Psychotic Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D012720:Severity of Illness Index; D055815:Young Adult
keywords: Electroencephalography (EEG); Graph theory; Healthy volunteers; Psychotic disorders; Small-world network