title: Association of the CYP4F2 rs2108622 genetic polymorphism with hypertension: a meta-analysis.
abstract: Previous case-control studies on the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension have produced contrasting results. In this study, we aimed to further evaluate the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension. We selected four case-control studies related to the CYP4F2 gene rs2108622 polymorphism and hypertension by searching PubMed, EMBase, the Chinese Biomedical Literature Database, and the Wanfang database. We utilized the Cochran Q-test and the I2 index to measure the heterogeneity across studies. To merge the odds ratio (OR) and the 95% confidence interval (95%CI), we utilized the fixed and random-effect models during the analyses. The present study included 1878 patients with hypertension and 1512 healthy control subjects. By meta-analysis, we did not find any association of the CYP4F2 gene rs2108622 polymorphism with hypertension in either genotype or allele distribution [AA+AG vs GG: OR = 1.18, 95%CI (0.91-1.54), P = 0.21; GG+AG vs AA: OR = 0.91, 95%CI (0.80-1.05), P = 0.20; A allele vs G allele: OR = 1.04, 95%CI (0.93-1.16), P = 0.53]. We concluded that the CYP4F2 gene rs2108622 polymorphism was not associated with hypertension.
authors.affiliation: Department of Geriatrics, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: X-H
authors.initials: XH
authors.lastname: Luo
authors.affiliation: Railway Vocational and Technical College of Zhengzhou, Zhengzhou, China.
authors.forename: G-R
authors.initials: GR
authors.lastname: Li
authors.affiliation: Department of Geriatrics, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: H-Y
authors.initials: HY
authors.lastname: Li
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D000072470:Cytochrome P450 Family 4; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D003577:Cytochrome P-450 Enzyme System; D000072470:Cytochrome P450 Family 4; C117480:CYP4F2 protein, human