title: Freezing of Gait in Parkinsonism and its Potential Drug Treatment.
abstract: Freezing of gait (FOG) is a heterogeneous symptom. Studies of treatment for FOG are scarce. Levodopa and monoamine oxidase inhibitors (rasagiline and selegiline) have shown effective improvement for FOG. Other drugs, such as L-threo-3, 4-dihydroxyphenylserine, amantadine, and botulinum toxin have exhibited some beneficial effects. The present review summarizes the potential drug treatment for FOG in Parkinsonism.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Zhang
authors.forename: S Duff
authors.initials: SD
authors.lastname: Canning
authors.affiliation: Department of Neurology, Shanghai First People's Hospital, Shanghai Jiao-Tong University, China. 200080. x_p_wang@sjtu.edu.cn.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000547:Amantadine / Q000627:therapeutic use; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D001905:Botulinum Toxins / Q000627:therapeutic use; D015103:Droxidopa / Q000627:therapeutic use; D020233:Gait Disorders, Neurologic / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007189:Indans / Q000627:therapeutic use; D007980:Levodopa / Q000627:therapeutic use*; D008774:Methylphenidate / Q000627:therapeutic use; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use*; D020734:Parkinsonian Disorders / Q000150:complications*; D012642:Selegiline / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000978:Antiparkinson Agents; D007189:Indans; D008996:Monoamine Oxidase Inhibitors; C031967:rasagiline; D008774:Methylphenidate; D012642:Selegiline; D007980:Levodopa; D000547:Amantadine; D001905:Botulinum Toxins; D015103:Droxidopa