title: Cylindroxanthones A-C, three new xanthones and their cytotoxicity from the stem bark of Garcinia cylindrocarpa.
abstract: Three new xanthones, cylindroxanthones A-C (1-3), were isolated from the stem bark of Garcinia cylindrocarpa. The structures were established on the basis of spectroscopic analysis. The molecular structure of 1 was unequivocally confirmed by single-crystal X-ray diffraction analysis. These three xanthones were evaluated regarding their cytotoxicity against KB, HeLa S-3, HT-29, MCF-7, and Hep G2 cancer cell lines. Compound 1 exhibited good cytotoxicity against KB cell with IC50 value of 2.36 μM.
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand; Natural Products and Synthesis Chemistry Research Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Sepuluh Nopember, Kampus ITS-Sukolilo, Surabaya 60111, Indonesia.
authors.forename: Edwin Risky
authors.initials: ER
authors.lastname: Sukandar
authors.affiliation: Natural Products and Synthesis Chemistry Research Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Sepuluh Nopember, Kampus ITS-Sukolilo, Surabaya 60111, Indonesia. Electronic address: taslimersam@its.ac.id.
authors.forename: Taslim
authors.initials: T
authors.lastname: Ersam
authors.affiliation: Natural Products and Synthesis Chemistry Research Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Sepuluh Nopember, Kampus ITS-Sukolilo, Surabaya 60111, Indonesia.
authors.forename: Sri
authors.initials: S
authors.lastname: Fatmawati
authors.affiliation: Natural Products Research Section, Research Division, National Cancer Institute, Bangkok 10400, Thailand.
authors.forename: Pongpun
authors.initials: P
authors.lastname: Siripong
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Thammarat
authors.initials: T
authors.lastname: Aree
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: Santi.Ti@chula.ac.th.
authors.forename: Santi
authors.initials: S
authors.lastname: Tip-pyang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D044004:Xanthones / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones
keywords: Cylindroxanthones A–C; Cytotoxicity; Garcinia cylindrocarpa; Xanthone