title: Decreased pretreatment serum cholesterol level is related with poor prognosis in resectable non-small cell lung cancer.
abstract: The cholesterol has been reported to be associated with cancer development. The aim of our study was to investigate the serum cholesterol level (TC) in non-small cell lung cancer (NSCLC) patients and their association with clinicopathologic parameters and the prognosis. The serum cholesterol levels were evaluated in 259 resected NSCLC patients and were correlated with clinicopathologic variables including age, gender, tumor size, regional lymph node metastasis, disease-free survival time and overall survival time. Preoperative serum TC level was significantly associated with gender (P=0.001), smoking history (P=0.016), tumor differentiation (P=0.027), pT stage (P<0.001) and pN stage (P=0.009). Multivariate analyses indicated that decreased serum TC level was an independent prognostic factor for worse outcome. The hazard ratio was 1.89 (95% confidence interval [CI] 1.09-3.26) for disease progression and 2.19 (95% CI 1.01-4.74) for death. Based on this finding, the pretreatment serum cholesterol level is a novel independent prognostic biomarker in resectable NSCLC.
authors.affiliation: Department of Medical Oncology, Jiaxing First Hospital Jiaxing 314001, Zhejiang Province, China.
authors.forename: Jin-Rui
authors.initials: JR
authors.lastname: Li
authors.affiliation: Department of Medical Oncology, Jiaxing First Hospital Jiaxing 314001, Zhejiang Province, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Medical Oncology, Jiaxing First Hospital Jiaxing 314001, Zhejiang Province, China.
authors.forename: Jia-Lian
authors.initials: JL
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000401:mortality / Q000556:secondary / Q000601:surgery; D002454:Cell Differentiation; D016009:Chi-Square Distribution; D002681:China; D002784:Cholesterol / Q000097:blood*; D018572:Disease-Free Survival; D015536:Down-Regulation; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011013:Pneumonectomy; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002784:Cholesterol
keywords: Cholesterol; non-small cell lung cancer; prognosis; surgery