title: Neurodevelopmental Status of Children Aged 6-30 Months With Congenital Heart Disease.
abstract: BACKGROUND
  Children with congenital heart diseases (CHD) are considered to be at high-risk for neurodevelopmental delay, but scant Indian data are available.
  
  
  OBJECTIVE
  To evaluate the neurodevelopmental status of children with CHD.
  
  
  METHODS
  We enrolled consecutive children aged 6-30 months with echocardiographically-confirmed CHD between June 2013 and January 2014. Children with clinically recognizable genetic syndromes or disorders; visual and/or hearing deficits, and microcephaly; and post-cardiac surgery children were excluded. Development was assessed by Developmental Assessment Scale for Indian Infants (DASII) and Developmental delay defined as Development Quotient (DQ) <70 in either the mental or motor scale.
  
  
  RESULTS
  75 children (53 males) with CHD were enrolled. Acyanotic CHD was seen in 51 children (VSD in 47%), and Tetralogy of Fallot was the commonest cyanotic CHD (25%). Developmental delay was seen in 25% of these children, more in the motor domain (48%) than in mental (12%). Mean motor and mental DQ in acyanotic CHD was 77 and 84, respectively; and 65 and 85, respectively in cyanotic CHD. Mean motor DQ was significantly less than mental DQ in both acyanotic and cyanotic CHD children (P=0.048).
  
  
  CONCLUSIONS
  Children with CHD are at an increased risk for developmental delay. Periodic surveillance, screening and evaluation should be instituted in them for early identification and appropriate interventions to enhance later academic, behavioral, psycho-social and adaptive function.
authors.affiliation: Department of Pediatrics, Lok Nayak Hospital; and *Department of Cardiology, GB Pant Hospital; Maulana Azad Medical College, New Delhi, India. Correspondence to: Dr Devendra Mishra, Departments of Pediatrics, Maulana Azad Medical College, New Delhi, India. drdmishra@gmail.com.
authors.forename: Kusum
authors.initials: K
authors.lastname: Lata
authors.forename: Devendra
authors.initials: D
authors.lastname: Mishra
authors.forename: Vimal
authors.initials: V
authors.lastname: Mehta
authors.forename: Monica
authors.initials: M
authors.lastname: Juneja
mesh_terms: D002675:Child, Preschool; D015331:Cohort Studies; D003490:Cyanosis; D002658:Developmental Disabilities / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications* / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D008297:Male