title: Intrapartum fetal heart rate patterns of trisomy 21 fetuses: A case-control study.
abstract: OBJECTIVE
  To determine whether there are specific characteristic intrapartum heart rate patterns for fetuses with trisomy 21(T21).
  Intrapartum fetal heart rate (FHR) tracings of T21 fetuses were compared to those of euploid fetuses in a retrospective, observational, matched, case-control study. The study group consisted of 42 fetuses with T21 and 42 matched euploid controls. Matching was designed to accommodate possible confounders. The sign test and McNemar's test were used for categorical variables. The paired t test was used for comparison between quantitative variables.
  
  
  RESULTS
  Intrapartum baseline FHR of fetuses with T21 was found to be slightly decreased compared to controls (122.5 vs 129.05 beats per minute, p=0.028). No differences were detected in the presence of periodic changes, or FHR variability between the groups.
  
  
  CONCLUSIONS
  When evaluating intrapartum FHR of fetuses with T21, decreased baseline FHR can be expected.
authors.affiliation: Department of Pediatric Medicine, Shaare Zedek Medical Center, Jerusalem 91031, Israel.
authors.forename: Inbal
authors.initials: I
authors.lastname: Koren
authors.affiliation: Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Post Box 3125, Jerusalem 91031, Israel.
authors.forename: Rachel
authors.initials: R
authors.lastname: Michaelson-Cohen
authors.affiliation: Tel Aviv University, Sackler School of Medicine, Israel.
authors.forename: Daniela
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Post Box 3125, Jerusalem 91031, Israel.
authors.forename: Jennia
authors.initials: J
authors.lastname: Michaeli
authors.affiliation: Department of Pediatric Medicine, Shaare Zedek Medical Center, Jerusalem 91031, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Schimmel
authors.affiliation: Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Post Box 3125, Jerusalem 91031, Israel.
authors.forename: Avi
authors.initials: A
authors.lastname: Tsafrir
authors.affiliation: Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Post Box 3125, Jerusalem 91031, Israel. Electronic address: orishen@netvision.net.il.
authors.forename: Ori
authors.initials: O
authors.lastname: Shen
mesh_terms: D016022:Case-Control Studies; D004314:Down Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005318:Fetal Heart / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy
keywords: Down syndrome; Fetal bradycardia; Fetal heart rate; Intrapartum monitoring; Reactivity; Trisomy 21; Variability