title: Probabilistic models and numerical calculation of system matrix and sensitivity in list-mode MLEM 3D reconstruction of Compton camera images.
abstract: This paper addresses the problem of evaluating the system matrix and the sensitivity for iterative reconstruction in Compton camera imaging. Proposed models and numerical calculation strategies are compared through the influence they have on the three-dimensional reconstructed images. The study attempts to address four questions. First, it proposes an analytic model for the system matrix. Second, it suggests a method for its numerical validation with Monte Carlo simulated data. Third, it compares analytical models of the sensitivity factors with Monte Carlo simulated values. Finally, it shows how the system matrix and the sensitivity calculation strategies influence the quality of the reconstructed images.
authors.affiliation: Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1044, INSA-Lyon, Université Lyon 1, France.
authors.forename: Voichita
authors.initials: V
authors.lastname: Maxim
authors.forename: Xavier
authors.initials: X
authors.lastname: Lojacono
authors.forename: Estelle
authors.initials: E
authors.lastname: Hilaire
authors.forename: Jochen
authors.initials: J
authors.lastname: Krimmer
authors.forename: Etienne
authors.initials: E
authors.lastname: Testa
authors.forename: Denis
authors.initials: D
authors.lastname: Dauvergne
authors.forename: Isabelle
authors.initials: I
authors.lastname: Magnin
authors.forename: Rémy
authors.initials: R
authors.lastname: Prost
mesh_terms: D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D015233:Models, Statistical; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*