title: 4-Kallikrein Test and Kallikrein Markers in Prostate Cancer Screening.
abstract: A preponderance of clinical evidence supports a significant public health benefit for prostate-specific antigen (PSA)-based screening and early detection of prostate cancer in appropriately counseled and selected men. Population-based screening with PSA decreases prostate cancer mortality; however, because of relatively poor specificity, PSA-based screening may also increase the detection of clinically insignificant cancers that would otherwise never require treatment. Use of newer biomarkers that increase the specificity for prostate cancer detection may aid in risk stratification and the appropriate identification of men for prostate biopsy. The authors review the 4-kallikrein panel and 4K probability score.
authors.affiliation: Department of Urology, UC San Diego Health, 200 West Arbor Drive #8897, San Diego, CA 92103-8897, USA.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: McDonald
authors.affiliation: Department of Urology, UC San Diego Health, 200 West Arbor Drive #8897, San Diego, CA 92103-8897, USA. Electronic address: jkparsons@ucsd.edu.
authors.forename: J Kellogg
authors.initials: JK
authors.lastname: Parsons
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D001706:Biopsy; D006801:Humans; D007610:Kallikreins / Q000097:blood*; D008297:Male; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D018570:Risk Assessment; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D007610:Kallikreins; C120801:kallikrein 4; D017430:Prostate-Specific Antigen
keywords: Biomarker; Detection; Kallikrein panel (4K panel); Kallikrein score (4Kscore); Prostate cancer; Screening