title: Micronutrients: A double-edged sword in microbial-induced gastric carcinogenesis.
abstract: Epidemiologic studies throughout the world have uniformly demonstrated significant relationships between the intake of dietary micronutrients and gastric cancer risk. An exciting concept that has gained considerable traction recently is that micronutrients modulate gene expression withinHelicobacter pylori, the strongest identified risk factor for gastric carcinogenesis. We present evidence here that essential micronutrients have a direct effect onH. pylorivirulence, which subsequently affects interactions at the host-pathogen interface, thereby facilitating the development of premalignant and malignant lesions in the stomach. Further, these fundamental concepts provide a framework for understanding mechanisms driving the development of other malignancies that arise from foci of gastrointestinal inflammation.
authors.affiliation: Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, 2215 Garland Avenue, MRB IV 1030C, Nashville, TN 37232-0252, , , jennifer.noto@vanderbilt.edu.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Noto
authors.affiliation: Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, 2215 Garland Avenue MRB IV 1030C, Nashville, TN 37232-0252, , , richard.peek@vanderbilt.edu.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Peek
keywords: Gastrointestinal cancer; Helicobacter pylori; gastric cancer; heme; iron; zinc