title: Prognostic Value of FDG-PET/CT Total Lesion Glycolysis for Patients with Resectable Distal Bile Duct Adenocarcinoma.
abstract: OBJECTIVE
  We investigated the prognostic value of clinicopathological factors in patients with a distal bile duct adenocarcinoma after curative resection.
  
  
  METHODS
  This retrospective study included 25 patients who underwent (18)F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG-PET/CT) before surgery. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured using FDG-PET/CT. FDG-PET/CT parameters and other clinicopathological factors were assessed to evaluate survival.
  
  
  RESULTS
  Univariate survival analysis showed that high TLG, high MTV, and high SUVmax were significant prognostic predictors for poor overall survival. For progression-free survival, high TLG and large tumor size were significant predictors for a poor prognosis. After multivariate survival analysis, only high TLG was an independent prognostic predictor for poor overall survival (p=0.025).
  
  
  CONCLUSIONS
  Preoperative assessment of TLG by FDG-PET/CT might be a useful prognostic predictor in patients with a distal bile duct adenocarcinoma after curative resection.
authors.affiliation: Department of Nuclear Medicine, Seoul Medical Center, Seoul, Republic of Korea.
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Lee
authors.affiliation: Department of Surgery, Digestive Disease Center, Research Institute of Biomedical Science, Konkuk University School of Medicine, Seoul, Republic of Korea.
authors.forename: Seong-Hwan
authors.initials: SH
authors.lastname: Chang
authors.affiliation: Department of Internal Medicine, Digestive Disease Center, Research Institute of Biomedical Science, Konkuk University School of Medicine, Seoul, Republic of Korea.
authors.forename: Tae Yoon
authors.initials: TY
authors.lastname: Lee
authors.affiliation: Division of Hematooncology, Department of Internal Medicine, Research Institute of Biomedical Science, Konkuk University School of Medicine, Seoul, Republic of Korea.
authors.forename: So Young
authors.initials: SY
authors.lastname: Yoon
authors.affiliation: Department of Internal Medicine, Digestive Disease Center, Research Institute of Biomedical Science, Konkuk University School of Medicine, Seoul, Republic of Korea.
authors.forename: Young Koog
authors.initials: YK
authors.lastname: Cheon
authors.affiliation: Department of Internal Medicine, Digestive Disease Center, Research Institute of Biomedical Science, Konkuk University School of Medicine, Seoul, Republic of Korea.
authors.forename: Chan Sup
authors.initials: CS
authors.lastname: Shim
authors.affiliation: Department of Nuclear Medicine, Konkuk University Medical Center, Research Institute of Biomedical Science, Konkuk University School of Medicine, Seoul, Republic of Korea.
authors.forename: Young
authors.initials: Y
authors.lastname: So
authors.affiliation: Department of Nuclear Medicine, Konkuk University Medical Center, Research Institute of Biomedical Science, Konkuk University School of Medicine, Seoul, Republic of Korea hwchung@kuh.ac.kr.
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Chung
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D005260:Female; D019788:Fluorodeoxyglucose F18; D006019:Glycolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011379:Prognosis; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: cholangiocarcinoma; distal bile duct; positron-emission tomography; prognosis; total lesion glycolysis