title: The utility of 18F-FDG PET/CT in solitary fibrous tumors of the pleura.
abstract: OBJECTIVE
  To demonstrate the utility of (18)F-FDG PET/CT in the differentiation of benign and malignant solitary fibrous tumors of the pleura (SFTP).
  
  
  METHODS
  A retrospective review was performed on the (18)F-FDG PET/CT data from 17 patients with histopathologically diagnosed benign or malignant SFTP. The size, side of SFTP, presence of necrosis, calcification, pleural effusion, hilar lymphadenopathy (LAP), density on CT images (Hounsfield unit-HU), and (18)F-FDG uptake (SUVmax) were recorded and compared in order to detect malignant SFTP. Statistical significance was set as p<0.05.
  
  
  RESULTS
  The difference in size, presence of necrosis, and hilar LAP on CT images were statistically significant (p=0.004, p<0.001, p=0.015, respectively) in a comparison of benign and malignant SFTPs. The mean HU of benign SFTP was 46.16±5.52HU, and for malignant SFTP it was 35.03±4.61HU (p=0.003). The mean SUVmax was 3.02±1.02 for benign SFTP and 4.89±2.12 for malignant SFTP (p=0.021). A cut-off value of ≥7cm for size, ≤39.81HU for density, and ≥3.47 for SUVmax was obtained by ROC analysis for detecting malignant SFTP.
  
  
  CONCLUSIONS
  (18)F-FDG PET/CT may have a limited role in diagnosing malignant SFTP in suspected patients.
authors.affiliation: Department of Nuclear Medicine, Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Tazeler
authors.affiliation: Department of Nuclear Medicine, Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Tan
authors.affiliation: Department of Radiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey. Electronic address: aslahmet@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Aslan
authors.affiliation: Department of Radiology, Medical School of Kırıkkale University, Kırıkkale, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Tan
mesh_terms: D019788:Fluorodeoxyglucose F18; D006801:Humans; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D054363:Solitary Fibrous Tumor, Pleural / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: (18)F-FDG PET; (18)F-FDG PET/CT; (18)F-FDG PET/TC; Computed tomography; Maximum standardized uptake value; Máximo valor de captación estandarizado; Pleura; Solitary fibrous tumor of the pleura; Tomografía computarizada; Tumor fibroso solitario de la pleura