title: Microenviromental change after synthetic E-selectins interfere in ischemia-reperfusion in rats and its contribution to endogenetic/exogenous never stem cells.
abstract: OBJECTIVE
  To explore the special significances in advantages of using anti-inflammatory drugs, such as amelioration of growing conditions and the promotion of cell growth.
  
  
  METHODS
  Utilizing anti-adhesive effects of synthetic E-selectins, we observed the changes of inflammatory cytokines (TNF-α, IL-1β) contented in brain tissues and rat serums in rats hind cerebral ischemia-reperfusion models. Both growth and expression of endogenetic/exogenous neurological stem cells were detected after ameliorated local microenvironment.
  
  
  RESULTS
  The contents of TNF-α and IL-1β were decreased in brain tissues and rat serums after applying synthetic E-selectins. Expression of exogenous neurological stem cells was enhanced. Animal neurological functions improved.
  
  
  CONCLUSIONS
  Anti-inflammatory therapy in early stage could enhance proliferation of stem cells so that it has vital significations in treating cerebrovascular diseases.
authors.affiliation: Department of Emergency Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu Province, China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Lin
authors.affiliation: Department of Emergency Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu Province, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Emergency Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu Province, China.
authors.forename: Long
authors.initials: L
authors.lastname: Bao
authors.affiliation: Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu Province, China.
authors.forename: Shi-Ying
authors.initials: SY
authors.lastname: Zheng
authors.affiliation: Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu Province, China ; The Affiliated Wujin People's Hospital of Jiangsu University Changzhou 213000, Jiangsu Province, China.
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Shen
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002545:Brain Ischemia / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D049109:Cell Proliferation / Q000187:drug effects; D019610:Cytoprotection; D004195:Disease Models, Animal; D019040:E-Selectin / Q000494:pharmacology*; D005260:Female; D053583:Interleukin-1beta / Q000097:blood; D008297:Male; D058953:Neural Stem Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function; D015427:Reperfusion Injury / Q000097:blood / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D055153:Stem Cell Niche; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000893:Anti-Inflammatory Agents; D019040:E-Selectin; C000594089:IL1B protein, rat; D053583:Interleukin-1beta; D018696:Neuroprotective Agents; D014409:Tumor Necrosis Factor-alpha
keywords: Ischemia-reperfusion; endogenetic/exogenous never stem cells; inflammatory cytokines; synthetic e-selectins