title: Application of Tranexamic Acid in Trauma and Orthopedic Surgery.
abstract: Tranexamic acid has gained recent interest in orthopedics and trauma surgery because of its demonstrated benefit in several clinical trials. It is inexpensive and effective at reducing blood loss and blood transfusion requirements without a significant increase in morbidity or mortality. The optimal timing, dosing, and route of administration in orthopedics are yet to be elucidated. Significant investigation of tranexamic acid use in joint replacement and spine surgery has promoted its incorporation into the everyday practice of many of these surgeons. The paucity of studies regarding its use in orthopedic trauma has limited its integration into a field that may stand to benefit most from the drug.
authors.affiliation: Department of Orthopaedics and Sports Medicine, Temple University Hospital, 3401 North Broad Street, Zone B 5th Floor, Philadelphia, PA 19140, USA. Electronic address: john.jennings2@tuhs.temple.edu.
authors.forename: John D
authors.initials: JD
authors.lastname: Jennings
authors.affiliation: Department of Orthopaedics and Sports Medicine, Temple University Hospital, 3401 North Broad Street, Zone B 5th Floor, Philadelphia, PA 19140, USA.
authors.forename: Mark K
authors.initials: MK
authors.lastname: Solarz
authors.affiliation: Department of Orthopaedics and Sports Medicine, Temple University Hospital, 3401 North Broad Street, Zone B 5th Floor, Philadelphia, PA 19140, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Haydel
mesh_terms: D000933:Antifibrinolytic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D006801:Humans; D019637:Orthopedic Procedures; D014148:Tranexamic Acid / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014947:Wounds and Injuries / Q000601:surgery*
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid
keywords: Antifibrinolytics; Hemorrhage; Orthopedics; Tranexamic acid; Transfusion; Trauma