title: Significance of the disc damage likelihood scale objectively measured by a non-mydriatic fundus camera in preperimetric glaucoma.
abstract: OBJECTIVE
  To assess the correlation between the disc damage likelihood scale (DDLS) objectively measured by a non-mydriatic fundus camera, Heidelberg Retina Tomograph 3, and optic coherence tomography in preperimetric glaucoma.
  
  
  METHODS
  One-hundred-twenty-five patients with preperimetric primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (n=30) were included (mean age 58.9±15.9 years). All three devices graded the optic disc topography: Diagnosis 1 was defined as "outside normal limits", while Diagnosis 2 as "borderline or outside normal limits".
  
  
  RESULTS
  For Diagnosis 1, a significant correlation was shown between DDLS and Moorfields regression analysis (P=0.022), and for Diagnosis 2 with glaucoma probability score analysis (P=0.024), in POAG. In pseudoexfoliation glaucoma, DDLS did not correlate significantly with Heidelberg Retina Tomograph 3 and optic coherence tomography. Regarding the area under the curve the highest predictive power was demonstrated by the objective DDLS (0.513-0.824) compared to Burk (0.239-0.343) and Mikelberg (0.093-0.270) coefficients.
  
  
  CONCLUSIONS
  The DDLS showed a significant correlation to the Moorfields regression analysis in preperimetric POAG. The objective DDLS showed the highest predictive power and thus is an additive tool in diagnosing preperimetric glaucoma.
authors.affiliation: Department of Ophthalmology, University Medicine Charité, Campus Virchow Clinic, Berlin, Germany.
authors.forename: Milena
authors.initials: M
authors.lastname: Pahlitzsch
authors.affiliation: Department of Ophthalmology, University Medicine Charité, Campus Virchow Clinic, Berlin, Germany.
authors.forename: Necip
authors.initials: N
authors.lastname: Torun
authors.affiliation: Augenklinik am Wittenbergplatz, Berlin, Germany.
authors.forename: Carl
authors.initials: C
authors.lastname: Erb
authors.affiliation: Department of Ophthalmology, University Medicine Charité, Campus Virchow Clinic, Berlin, Germany.
authors.forename: Jeanette
authors.initials: J
authors.lastname: Bruenner
authors.affiliation: Department of Ophthalmology, University Medicine Charité, Campus Virchow Clinic, Berlin, Germany.
authors.forename: Anna Karina B
authors.initials: AK
authors.lastname: Maier
authors.affiliation: Department of Ophthalmology, University Medicine Charité, Campus Virchow Clinic, Berlin, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Gonnermann
authors.affiliation: Department of Ophthalmology, University Medicine Charité, Campus Virchow Clinic, Berlin, Germany.
authors.forename: Eckart
authors.initials: E
authors.lastname: Bertelmann
authors.affiliation: Department of Ophthalmology, University Medicine Charité, Campus Virchow Clinic, Berlin, Germany.
authors.forename: Matthias K J
authors.initials: MK
authors.lastname: Klamann
keywords: DDLS; Heidelberg Retina Tomograph; optic coherence tomography; preperimetric glaucoma; stereophotography