title: Diffuse mesangial and endocapillary cell proliferative glomerulonephritis with persistent hypocomplementemia in a child.
abstract: A 15-year-old boy was admitted to People's Hospital of Dong E with anasarca. The laboratory findings revealed proteinuria, hematuria, hypocomplementemia. Renal biopsy specimen revealed diffuse mesangial and endocapillary cell proliferative glomerulonephritis on light microscopic (LM) examination. On immunofluorescence (IF) examination, deposition of IgG, IgA, C3, C1q and F to capillary wall and subendothelial were observed. By means of electron microscopy (EM), subendothelial electron-dense deposits and segmental fusion of epithelial cell foot process were recognized. He was treated by only some supportive drugs, no ACEI/ARB, without glucocorticoids and immunosuppressive agents. About one month later, complete remission of proteinuria occurred. During next 62-weeks follow up, urinary analysis always showed microscopic hematuria. However, it is interesting to note that the serum complement C3 and C4 levels remained persistently low.
authors.affiliation: Shandong University Jinan 250100, P. R. China ; Department of Nephrology, People's Hospital of Dong E county Liaocheng 252200, People's P. R. China.
authors.forename: Jun-Mei
authors.initials: JM
authors.lastname: Xu
authors.affiliation: Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, P. R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
keywords: Acute glomerulonephritis; hypocomplementemia; mesangial and endocapillary proliferative glomerulonephritis