title: Elevated plasma inflammatory mediators in post-polio syndrome: No association with long-term functional decline.
abstract: A key feature of post-polio syndrome (PPS) is progressive loss of muscle strength. In other chronic diseases systemic inflammation has been linked to muscle wasting. In this study plasma TNF-α, IL-6, IL-8, and leptin levels were significantly increased in PPS-patients compared to healthy controls. There was however no association between these raised systemic levels of inflammatory mediators and long-term decline in quadriceps strength or other clinical parameters. In conclusion, there is evidence for systemic inflammation in PPS, yet the relationship with clinical deterioration remains tenuous.
authors.affiliation: Department of Rehabilitation, AMC, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands. Electronic address: alicebick@yahoo.co.uk.
authors.forename: A
authors.initials: A
authors.lastname: Bickerstaffe
authors.affiliation: Department of Rehabilitation, AMC, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands. Electronic address: j.a.beelen@amc.nl.
authors.forename: A
authors.initials: A
authors.lastname: Beelen
authors.affiliation: Department of Immunology, AMC, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands. Electronic address: r.lutter@amc.nl.
authors.forename: R
authors.initials: R
authors.lastname: Lutter
authors.affiliation: Department of Rehabilitation, AMC, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands. Electronic address: f.nollet@amc.nl.
authors.forename: F
authors.initials: F
authors.lastname: Nollet
mesh_terms: D000328:Adult; D015331:Cohort Studies; D016207:Cytokines / Q000097:blood*; D004576:Electromyography; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology; D016262:Postpoliomyelitis Syndrome / Q000097:blood / Q000150:complications / Q000276:immunology; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology*; D016138:Walking / Q000502:physiology
chemical_list: D016207:Cytokines; D020738:Leptin
keywords: Cytokines; Motor neurons/pathology; Muscle strength; Postpoliomyelitis syndrome