title: The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan.
abstract: Lifespan is a remarkably diverse trait ranging from a few days to several hundred years in nature, but the mechanisms underlying the evolution of lifespan differences remain elusive. Here we de novo assemble a reference genome for the naturally short-lived African turquoise killifish, providing a unique resource for comparative and experimental genomics. The identification of genes under positive selection in this fish reveals potential candidates to explain its compressed lifespan. Several aging genes are under positive selection in this short-lived fish and long-lived species, raising the intriguing possibility that the same gene could underlie evolution of both compressed and extended lifespans. Comparative genomics and linkage analysis identify candidate genes associated with lifespan differences between various turquoise killifish strains. Remarkably, these genes are clustered on the sex chromosome, suggesting that short lifespan might have co-evolved with sex determination. Our study provides insights into the evolutionary forces that shape lifespan in nature.
authors.affiliation: Department of Genetics, Stanford University, California 94305, USA. Electronic address: dario.valenzano@age.mpg.de.
authors.forename: Dario Riccardo
authors.initials: DR
authors.lastname: Valenzano
authors.affiliation: Department of Genetics, Stanford University, California 94305, USA.
authors.forename: Bérénice A
authors.initials: BA
authors.lastname: Benayoun
authors.affiliation: Department of Genetics, Stanford University, California 94305, USA.
authors.forename: Param Priya
authors.initials: PP
authors.lastname: Singh
authors.affiliation: Department of Genetics, Stanford University, California 94305, USA.
authors.forename: Elisa
authors.initials: E
authors.lastname: Zhang
authors.affiliation: Institute of Molecular Biology, University of Oregon, Oregon 97403, USA.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Etter
authors.affiliation: Department of Genetics, Stanford University, California 94305, USA.
authors.forename: Chi-Kuo
authors.initials: CK
authors.lastname: Hu
authors.affiliation: CMMC, University of Cologne, Cologne, 50931, Germany.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Clément-Ziza
authors.affiliation: Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Willemsen
authors.affiliation: Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.
authors.forename: Rongfeng
authors.initials: R
authors.lastname: Cui
authors.affiliation: Department of Genetics, Stanford University, California 94305, USA.
authors.forename: Itamar
authors.initials: I
authors.lastname: Harel
authors.affiliation: Department of Genetics, Stanford University, California 94305, USA.
authors.forename: Ben E
authors.initials: BE
authors.lastname: Machado
authors.affiliation: Department of Genetics, Stanford University, California 94305, USA.
authors.forename: Muh-Ching
authors.initials: MC
authors.lastname: Yee
authors.affiliation: Department of Genetics, Stanford University, California 94305, USA.
authors.forename: Sabrina C
authors.initials: SC
authors.lastname: Sharp
authors.affiliation: Department of Genetics, Stanford University, California 94305, USA.
authors.forename: Carlos D
authors.initials: CD
authors.lastname: Bustamante
authors.affiliation: Cellular Networks and Systems Biology, CECAD, University of Cologne, Cologne, 50931, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Beyer
authors.affiliation: Institute of Molecular Biology, University of Oregon, Oregon 97403, USA.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Johnson
authors.affiliation: Department of Genetics, Stanford University, California 94305, USA; Glenn Laboratories for the Biology of Aging, Stanford University, California 94305, USA. Electronic address: anne.brunet@stanford.edu.
authors.forename: Anne
authors.initials: A
authors.lastname: Brunet
mesh_terms: D000375:Aging; D000818:Animals; D005075:Biological Evolution; D004265:DNA Helicases / Q000235:genetics; D016678:Genome; D006801:Humans; D007695:Killifishes / Q000235:genetics*; D008136:Longevity; D058977:Molecular Sequence Annotation; D008969:Molecular Sequence Data; D012641:Selection, Genetic
chemical_list: D004265:DNA Helicases