title: Longitudinal Changes in the Brain Following Third Ventriculostomy in a Child With Hydrocephalus: A Case Report.
abstract: The goal of this study was to detect the long-term effect of shunting on the integrity of white matter in young children with hydrocephalus.The authors reported the case of a 6-month-old boy with hydrocephalus who was evaluated by diffusion tensor imaging (DTI) before and after a shunt operation.When compared with normal children, the structures of the corpus callosum, internal capsule, and corona radiata in the patient showed a decrease in fractional anisotropy and an increase in radial diffusivity values before the shunt operation. Following successful cerebrospinal fluid shunting, long-term follow-up DTI demonstrated a trend toward normalization of the fractional anisotropy and radial diffusivity values.Shunt treatment can prevent further damage to the brain and grossly reconstitute the distorted anatomy. DTI could be a useful tool in detecting longitudinal changes after a shunt operation. Further studies involving larger case numbers are needed to detect the long-term effect of shunting on the brains of children with hydrocephalus.
authors.affiliation: From the Institute of Clinical Anatomy, Southern Medical University, Guangzhou (YL, YW, JW, HG, BZ, WH); Department of Pediatric Radiology, Shenzhen Children Hospital (CZ); Department of Pediatric Neurosurgery, Shenzhen Children Hospital (ZT); and Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China (HZ).
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Li
authors.forename: Cailei
authors.initials: C
authors.lastname: Zhao
authors.forename: Zhen
authors.initials: Z
authors.lastname: Tan
authors.forename: Ya
authors.initials: Y
authors.lastname: Wang
authors.forename: Heye
authors.initials: H
authors.lastname: Zhang
authors.forename: Jinyang
authors.initials: J
authors.lastname: Wang
authors.forename: Honghua
authors.initials: H
authors.lastname: Guo
authors.forename: Baozhen
authors.initials: B
authors.lastname: Zeng
authors.forename: Wenhua
authors.initials: W
authors.lastname: Huang
mesh_terms: D056324:Diffusion Tensor Imaging; D006801:Humans; D006849:Hydrocephalus / Q000628:therapy*; D007223:Infant; D008297:Male; D014696:Ventriculostomy / Q000009:adverse effects*; D066127:White Matter / Q000473:pathology*