title: NIR-Remote Selected Activation Gene Expression in Living Cells by Upconverting Microrods.
abstract: An NIR-controlled gene expression system based on upconverting rods (UCRs) is demonstrated. The UCRs can harvest the "biocompatible" NIR light and convert it into local UV light, resulting in cleavage of the photosensitive molecule (4-(hydroxymethyl)-3-nitrobenzoic acid, ONA) and on-demand release of gene carriers, thus realizing target gene expression at high spatial and temporal resolutions.
authors.affiliation: School of Life Sciences, Tianjin University, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 92 Weijin Road, Nankai District, Tianjin, 300072, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zheng
authors.affiliation: School of Materials Science and Engineering, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Su
authors.affiliation: School of Life Sciences, Tianjin University, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 92 Weijin Road, Nankai District, Tianjin, 300072, P.R. China.
authors.forename: Huizhuo
authors.initials: H
authors.lastname: Pan
authors.affiliation: School of Materials Science and Engineering, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, P.R. China.
authors.forename: Beibei
authors.initials: B
authors.lastname: Hou
authors.affiliation: School of Life Sciences, Tianjin University, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 92 Weijin Road, Nankai District, Tianjin, 300072, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Materials Science and Engineering, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, P.R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhou
authors.affiliation: School of Life Sciences, Tianjin University, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 92 Weijin Road, Nankai District, Tianjin, 300072, P.R. China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wu
authors.affiliation: School of Life Sciences, Tianjin University, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 92 Weijin Road, Nankai District, Tianjin, 300072, P.R. China.
authors.forename: Xiaoqun
authors.initials: X
authors.lastname: Gong
authors.affiliation: School of Life Sciences, Tianjin University, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 92 Weijin Road, Nankai District, Tianjin, 300072, P.R. China.
authors.forename: Hanjie
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Tianjin University, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 92 Weijin Road, Nankai District, Tianjin, 300072, P.R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Chang
mesh_terms: D015870:Gene Expression; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009579:Nitrobenzoates / Q000737:chemistry; D010316:Particle Size; D011094:Polyethyleneimine / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D009579:Nitrobenzoates; D012235:Rhodamines; D049452:Green Fluorescent Proteins; D012822:Silicon Dioxide; D011094:Polyethyleneimine; C040770:3-nitrobenzoic acid
keywords: NIR-remote selected activation; gene expression; light-sensitive molecules; photosensitivity; upconverting rods