title: Tetranectin as a Potential Biomarker for Stable Coronary Artery Disease.
abstract: This cross-sectional study tested the hypothesis that decreased serum levels of tetranectin (TN), a regulator of the fibrinolysis and proteolytic system, is associated with the presence and severity of CAD. We conducted a systematic serological and immunohistochemical (IHC) analysis to respectively compare the TN levels in serum and artery samples in CAD patients and healthy controls. Our results showed that serum levels of TN were significantly lower in patients with CAD than in healthy controls. Further analysis via trend tests revealed that serum TN levels correlated with the number of diseased arteries. Besides, the multivariate logistic regression model revealed TN as an independent factor associated with the presence of CAD. Additionally, IHC analysis showed that TN expression was significantly higher in atherosclerotic arteries as compared to healthy control tissues. In conclusion, our study suggests that increased serum TN level is associated with the presence and severity of diseased coronary arteries in patients with stable CAD.
authors.affiliation: Department of Cardiology, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Yanjia
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Han
authors.affiliation: Department of Cardiology, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Cardiology, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Fenghua
authors.initials: F
authors.lastname: Ding
authors.affiliation: Department of Cardiology, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Xiuxiu
authors.initials: X
authors.lastname: Su
authors.affiliation: Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Wang
authors.affiliation: Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Qiujing
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Cardiology, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Ruiyan
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China.|Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jin
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood*; D003331:Coronary Vessels / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D037181:Lectins, C-Type / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D037181:Lectins, C-Type; C048648:tetranectin