title: Association and prediction of severe 5-fluorouracil toxicity with dihydropyrimidine dehydrogenase gene polymorphisms: A meta-analysis.
abstract: The aim of the present study was to evaluate the association and prediction of dihydropyrimidine dehydrogenase gene (DPYD) polymorphisms and the risk of 5-fluorouracil (5-FU) severe toxicity in cancer patients. A meta-analysis of the published literature was conducted to summarize evidence forDPYDgene polymorphisms associated with an increased risk of severe 5-FU toxicity in patients with cancer from an Asian population. Relevant literature was identified using the PubMed and Cochrane databases on April 11, 2014. Combined risk ratios and 95% confidence intervals (CIs) were calculated in a fixed-effects model. A total of 5 clinical studies were retrieved in the meta-analysis, including 764 cancer patients withDPYDgene polymorphisms who received 5-FU-based chemotherapy. Overall,DPYDgene polymorphisms were associated with the increased risk of 5-FU severe toxicity [risk ratio=2.54 (2.15-3.00); 95% CI, 19.46-84.57; P=0.0001]. In conclusion, the present meta-analysis suggested that polymorphisms of severalDPYDgene polymorphisms are associated with an increased risk of severe toxic response to 5-FU.
authors.affiliation: Department of Radiation Therapy, China Medical University-An Nan Hospital, Tainan 709, Taiwan, R.O.C.
authors.forename: Henry W C
authors.initials: HW
authors.lastname: Leung
authors.affiliation: Department of Pharmacy, China Medical University-An Nan Hospital, Tainan 709, Taiwan, R.O.C.
authors.forename: Agnes L F
authors.initials: AL
authors.lastname: Chan
keywords: 5-fluorouracil-associated toxicity; Asian population; dihydropyrimidine dehydrogenase gene polymorphism or variant