title: Assembly of Viral Membrane Proteins.
abstract: The generation of computational models is an alternative route to obtain reliable structures for the oligomeric state of membrane proteins. A strategy has been developed to search the conformational space of all possible assemblies in a reasonable time, taking symmetry considerations into account. The methodology tested on M2 from influenza A, shows an excellent agreement with established structures. For Vpu from HIV-1 a series of conformational distinct structures are proposed. For the first time a structural model for a fully assembled transmembrane part of 3a from SARS-CoV is proposed.
authors.affiliation: Institute of Biophotonics, School of Medical Science and Engineering, National Yang-Ming University, 155, Section 2, Li-Nong Street, Taipei 112, Taiwan.
authors.forename: J
authors.initials: J
authors.lastname: Krüger
authors.affiliation: Institute of Biophotonics, School of Medical Science and Engineering, National Yang-Ming University, 155, Section 2, Li-Nong Street, Taipei 112, Taiwan.
authors.forename: W B
authors.initials: WB
authors.lastname: Fischer