title: Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: Slow release and high solubility.
abstract: Electrospinning of polyacrylic acid (PAA) nanofibres (NF) incorporating β-cyclodextrin inclusion complex (β-CD-IC) of quercetin (QU) was performed. Here, β-CD was used as not only the crosslinking agent for PAA nanofibres but also as a host molecule for inclusion of QU. The phase solubility test showed enhanced solubility of QU due to the inclusion complexation; in addition, the stoichiometry of QU/β-CD-IC was determined to be 1:1. Computational modelling studies confirmed that 1:1 and 1:2 complex formation are desirable; 1:1 complex formation was chosen to have higher weight loading of QU. SEM images showed that PAA/QU/β-CD-IC-NF were bead-free and uniform. XRD indicated that PAA/QU/β-CD-IC-NF were amorphous in nature without the crystalline peaks of QU. Comparative results revealed that the release profile of QU from PAA/QU/β-CD-IC-NF was much slower but greater in total than from PAA/QU/β-CD-IC-film. Moreover, high antioxidant activity and photostability of QU was achieved in PAA/QU/β-CD-IC-NF.
authors.affiliation: Institute of Materials Science & Nanotechnology, Bilkent University, Ankara 06800, Turkey; UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Aytac
authors.affiliation: UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey; Department of Engineering Physics, Istanbul Medeniyet University, 34700 Göztepe-Istanbul, Turkey.
authors.forename: Semran Ipek
authors.initials: SI
authors.lastname: Kusku
authors.affiliation: Institute of Materials Science & Nanotechnology, Bilkent University, Ankara 06800, Turkey; UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Durgun
authors.affiliation: Institute of Materials Science & Nanotechnology, Bilkent University, Ankara 06800, Turkey; UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey. Electronic address: tamer@unam.bilkent.edu.tr.
authors.forename: Tamer
authors.initials: T
authors.lastname: Uyar
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D065546:Drug Liberation; D004355:Drug Stability; D008855:Microscopy, Electron, Scanning; D008958:Models, Molecular; D057139:Nanofibers / Q000737:chemistry*; D010316:Particle Size; D010851:Picrates / Q000737:chemistry; D011794:Quercetin / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D012995:Solubility; D013499:Surface Properties; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D004337:Drug Carriers; D010851:Picrates; D047392:beta-Cyclodextrins; D011794:Quercetin; C004931:1,1-diphenyl-2-picrylhydrazyl; C031215:betadex
keywords: Antioxidant activity; Electrospinning; Modelling; Nanofibres; Phase solubility; Photostability; Polyacrylic acid; Quercetin; β-Cyclodextrin