title: Expressions of stem cell transcription factors Nanog and Oct4 in renal cell carcinoma tissues and clinical significance.
abstract: We aimed to detect the expressions of stem cell transcription factors Nanog and Oct4 in renal cell carcinoma (RCC) tissues. Nanog and Oct4 mRNA expressions in RCC tissues significantly exceeded those in paracancerous tissues (p < 0.01 and p < 0.05), being positively correlated with histological grade (p < 0.01 and p < 0.05) and TNM stage (p < 0.05). With increasing TNM stage (p < 0.01) and lymphatic metastasis (p < 0.05), the positive expression rate of Nanog protein increased. RCC patients with low Nanog and Oct4 expressions in tumor tissues had significantly higher survival rates (p < 0.05). High Nanog and Oct4 expressions may be potential therapeutic targets.
authors.affiliation: a Department of Urology , Affiliated Cancer Hospital of Jiangsu Province of Nanjing Medical University , Nanjing , China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yu
authors.affiliation: a Department of Urology , Affiliated Cancer Hospital of Jiangsu Province of Nanjing Medical University , Nanjing , China.
authors.forename: Hongzhou
authors.initials: H
authors.lastname: Cai
authors.affiliation: a Department of Urology , Affiliated Cancer Hospital of Jiangsu Province of Nanjing Medical University , Nanjing , China.
authors.forename: Zicheng
authors.initials: Z
authors.lastname: Xu
authors.affiliation: a Department of Urology , Affiliated Cancer Hospital of Jiangsu Province of Nanjing Medical University , Nanjing , China.
authors.forename: Ting
authors.initials: T
authors.lastname: Xu
authors.affiliation: a Department of Urology , Affiliated Cancer Hospital of Jiangsu Province of Nanjing Medical University , Nanjing , China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zou
authors.affiliation: b Department of Urology , First Affiliated Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Min
authors.initials: M
authors.lastname: Gu
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000071317:Nanog Homeobox Protein / Q000096:biosynthesis*; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D050814:Octamer Transcription Factor-3 / Q000096:biosynthesis*; D015996:Survival Rate
chemical_list: C486780:NANOG protein, human; D000071317:Nanog Homeobox Protein; D009363:Neoplasm Proteins; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human
keywords: Expression; gene; renal cell carcinoma; transcription