title: [Measurement of antimicrobial consumption using DDD per 100 bed-days versus DDD per 100 discharges after the implementation of an antimicrobial stewardship program].
abstract: BACKGROUND
  Monitoring antimicrobial consumption in hospitals is a necessary measure. The indicators commonly employed do not clearly reflect the antibiotic selection pressure. The objective of this study is to evaluate two different methods that analyze antimicrobial consumption based on DDD, per stay and per discharge, before and after the implementation an antimicrobial stewardship program.
  
  
  METHODS
  Comparative pre-post study of antimicrobial consumption with the implementation of an antimicrobial stewardship program using DDD per 100 bed-days and DDD per 100 discharges as indicators.
  
  
  RESULTS
  Hospital bed days remained stable and discharges increased slightly along the period of study Antibiotic consumption in DDD per 100 bed-days decreased by 2.5% versus 3.8% when expressed as DDD per 100 discharges. Antifungal consumption decreased by more than 50%.
  
  
  CONCLUSIONS
  When average hospital stay decreases, reductions in the consumption of antimicrobials with an antimicrobial stewardship program system occur at the expense of reducing the number of patients receiving treatment, while increases occur due to longer durations of treatment.
authors.affiliation: Roberto Collado Borrell, Hospital Universitario Fundación Alcorcón, C/ Calle de Budapest 1. 28922, Alcorcón, Madrid, Spain. roberto.collado@salud.madrid.org.
authors.forename: Roberto
authors.initials: R
authors.lastname: Collado
authors.forename: Juan Emilio
authors.initials: JE
authors.lastname: Losa
authors.forename: Elena Alba
authors.initials: EA
authors.lastname: Álvaro
authors.forename: Piedad
authors.initials: P
authors.lastname: Toro
authors.forename: Leonor
authors.initials: L
authors.lastname: Moreno
authors.forename: Montserrat
authors.initials: M
authors.lastname: Pérez
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004363:Drug Utilization / Q000706:statistics & numerical data; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D057970:Inappropriate Prescribing / Q000517:prevention & control; D007902:Length of Stay; D010351:Patient Discharge; D015397:Program Evaluation; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents