title: Diagnosis of Periprosthetic Infection: Novel Developments.
abstract: The diagnosis of periprosthetic joint infection (PJI) has been performed by obtaining a history and physical examination, blood tests, and analysis of the synovial fluid and tissue samples. The measurement of serum biomarkers are routinely used to diagnose PJI. These markers may be elevated in other inflammatory conditions, necessitating the need for more specific biomarkers to diagnose PJI. Serum biomarkers may be more specific to PJI. Synovial CRP, α-defensin, human β-defensin-2 and -3, leukocyte esterase, and cathelicidin LL-37 biomarkers hold promise for the diagnosis of PJI.
authors.affiliation: Rothman Institute, Thomas Jefferson University, 4703 33rd Avenue Northeast, Seattle, WA 98105, USA. Electronic address: lauramatsenko@gmail.com.
authors.forename: Laura
authors.initials: L
authors.lastname: Matsen Ko
authors.affiliation: Sidney Kimmel School of Medicine, Rothman Institute, Thomas Jefferson University, Sheridan Building, Suite 1000, 125 South 9th Street, Philadelphia, PA 19107, USA.
authors.forename: Javad
authors.initials: J
authors.lastname: Parvizi
mesh_terms: D000465:Algorithms; D015415:Biomarkers / Q000097:blood*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D002116:Calcitonin / Q000097:blood; D016207:Cytokines / Q000378:metabolism*; D005629:Frozen Sections; D006801:Humans; D016459:Prosthesis-Related Infections / Q000175:diagnosis* / Q000473:pathology; D011498:Protein Precursors / Q000097:blood; D013582:Synovial Fluid / Q000737:chemistry*; D023084:alpha-Defensins / Q000378:metabolism
chemical_list: D015415:Biomarkers; D016207:Cytokines; D011498:Protein Precursors; D023084:alpha-Defensins; D002116:Calcitonin; D002097:C-Reactive Protein
keywords: Diagnosis; Periprosthetic joint infection; Serum markers; Synovial fluid markers; Total joint arthroplasty