title: Synthesis of Alocasin A.
abstract: Herein is reported a synthesis of alocasin A (1), an alkaloid component of Alocasia macrorrhiza, a herbaceous plant used in folk medicine throughout southern Asia. A double Suzuki-Miyaura cross-coupling reaction between a 3-borylindole and 2,5-dibromopyrazine was used to assemble the heteroaromatic framework of the natural product. Removal of the protecting groups gave a synthetic sample of 1, the spectroscopic data of which matched those in the isolation report of this compound.
authors.affiliation: School of Chemical Sciences, University of Auckland , 23 Symonds Street, Auckland 1142, New Zealand.
authors.forename: Se Hun
authors.initials: SH
authors.lastname: Kim
authors.affiliation: School of Chemical Sciences, University of Auckland , 23 Symonds Street, Auckland 1142, New Zealand.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Sperry
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D031055:Alocasia / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D008519:Medicine, Traditional; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D001688:Biological Products; C000607260:alocasin A