title: Diagnostic Biomarkers in Eosinophilic Renal Neoplasms.
abstract: Incidental small renal masses identified on imaging are increasingly investigated via needle core or fine needle aspiration biopsies with limited material provided for rendering a diagnosis. Lesions with a prominent eosinophilic or oncocytic cell presence showing morphologic overlap between well-known eosinophilic neoplasms are challenging to diagnose. We review the range of known benign and malignant eosinophilic renal neoplasms and their immunoprofiles to elucidate a useful panel of stains that may assist the pathologist in making an accurate diagnosis.
authors.affiliation: Department of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, Diagnostics Tower, Singapore 169856, Singapore.
authors.forename: Li Yan
authors.initials: LY
authors.lastname: Khor
authors.affiliation: Department of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, Diagnostics Tower, Singapore 169856, Singapore; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, MD10, 4 Medical Drive, Singapore 117594, Singapore; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, MD10, 4 Medical Drive, Singapore 117594, Singapore; Duke-NUS Graduate Medical School Singapore, 8 College Road, Singapore 169857, Singapore. Electronic address: tan.puay.hoon@sgh.com.sg.
authors.forename: Puay Hoon
authors.initials: PH
authors.lastname: Tan
mesh_terms: D014408:Biomarkers, Tumor / Q000276:immunology*; D044963:Biopsy, Fine-Needle; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000276:immunology; D004802:Eosinophilia / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D033162:Incidental Findings; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000276:immunology
chemical_list: D014408:Biomarkers, Tumor
keywords: Biomarkers; Biopsy; Eosinophilic; Renal cell carcinoma