title: An absolute calibration method of an ethyl alcohol biosensor based on wavelength-modulated differential photothermal radiometry.
abstract: In this work, laser-based wavelength-modulated differential photothermal radiometry (WM-DPTR) is applied to develop a non-invasive in-vehicle alcohol biosensor. WM-DPTR features unprecedented ethanol-specificity and sensitivity by suppressing baseline variations through a differential measurement near the peak and baseline of the mid-infrared ethanol absorption spectrum. Biosensor signal calibration curves are obtained from WM-DPTR theory and from measurements in human blood serum and ethanol solutions diffused from skin. The results demonstrate that the WM-DPTR-based calibrated alcohol biosensor can achieve high precision and accuracy for the ethanol concentration range of 0-100 mg/dl. The high-performance alcohol biosensor can be incorporated into ignition interlocks that could be fitted as a universal accessory in vehicles in an effort to reduce incidents of drinking and driving.
authors.affiliation: Department of Mechanical and Industrial Engineering, Center for Advanced Diffusion-Wave Technologies (CADIFT), University of Toronto, Toronto, Ontario M5S 3G8, Canada.
authors.forename: Yi Jun
authors.initials: YJ
authors.lastname: Liu
authors.affiliation: Department of Mechanical and Industrial Engineering, Center for Advanced Diffusion-Wave Technologies (CADIFT), University of Toronto, Toronto, Ontario M5S 3G8, Canada.
authors.forename: Andreas
authors.initials: A
authors.lastname: Mandelis
authors.affiliation: Department of Mechanical and Industrial Engineering, Center for Advanced Diffusion-Wave Technologies (CADIFT), University of Toronto, Toronto, Ontario M5S 3G8, Canada.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Guo
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods* / Q000592:standards; D002138:Calibration; D000431:Ethanol / Q000032:analysis*; D008956:Models, Chemical; D011874:Radiometry / Q000295:instrumentation / Q000379:methods / Q000592:standards
chemical_list: D000431:Ethanol