title: Primary cerebellopontine angle ependymoma with spinal metastasis in an adult patient: A case report.
abstract: Subtentorial ependymoma is a common central nervous system tumor in young children, but is uncommon in adults. Ependymoma often arises from the cells lining the fourth ventricle. The present study reports a rare case of primary ependymoma that originated from the cerebellopontine angle, with local extension to the two internal auditory canals and remote spinal metastasis, in an adult male. A 50-year-old male presented with headache, tinnitus and bilateral hearing loss that had persisted for 4 months. Magnetic resonance imaging (MRI) revealed a mass in each of the cerebellopontine angles, which had spread to each internal auditory canal and wrapped the VII/VIII cranial nerve complex. A gross total resection was performed to remove the mass in the right side. Histological examination confirmed that the tumor was a World Health Organization grade II papillary ependymoma. Notably, the patient complained of urine retention post-surgery and massive occupational lesions in T3-T4 and L5-S2 were found on full spinal cord MRI. The patient then received combination therapy consisting of temozolomide, and whole-brain and spinal cord radiation. In the final follow-up examination, performed 13 months after treatment, slight shrinkage of the T3 lesion was observed, and no progression of the left cerebellopontine angle and S5-L2 lesions were identified on MRI. In summary, although this clinical entity is rare, the diagnosis of ependymoma and the possibility of spinal cord metastasis should be considered in subtentorial tumors.
authors.affiliation: Guangzhou Medical University, Guangzhou, Guangdong 510182, P.R. China ; Department of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, P.R. China.
authors.forename: Chengcheng
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, P.R. China ; Shantou Medical University, Shantou, Guangdong 515043, P.R. China.
authors.forename: Chuanfang
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, P.R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, P.R. China.
authors.forename: Taipeng
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Central Laboratory, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, P.R. China.
authors.forename: Wenlan
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, P.R. China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Li
keywords: cerebellopontine angle; ependymoma; spinal metastasis