title: Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial.
abstract: OBJECTIVE
  Patients frequently experience pain of moderate to severe degree during gynaecologic procedures. This prospective, randomized, placebo-controlled trial was aimed to investigate the analgesic efficacy of preoperative oral dexketoprofen trometamol, intravenous paracetamol, lidocaine spray, pethidine and diclofenac sodium on fractional curettage procedure.
  
  
  METHODS
  A total of 144 multiparous women were randomly allocated to one of the six groups. The first group (control group) consisted of 22 participants and they did not receive any treatment. The second group had 26 participants receiving oral 25 mg dexketoprofen trometamol. The 23 participants of the third group received two puff lidocaine sprays on cervical mucosa. t0 he forth group consisted of 25 participants receiving 100 mg pethidine. In the fifth group, the 23 participants received 1000 mg intravenous paracetamol and the sixth group consisted of 25 participants receiving diclofenac sodium.
  
  
  RESULTS
  Pethidine was the best choice for reducing pain score during curettage procedure (t2:intra-operative). All analgesic procedures were significantly effective in reducing pain during postoperative period (t3). Significant pain reduction was achieved for both intra- and postoperative period by using analgesics.
  
  
  CONCLUSIONS
  The results of our study showed that lidocaine puffs provided the best pain relief than the other analgesics used. Therefore, lidocaine may be considered as the first choice analgesic in fractional curettage (NCT ID: 01993589).
authors.affiliation: Department of Obstetrics & Gynecology, Kayseri Education & Research Hospital, Kayseri, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Acmaz
authors.forename: Evrim
authors.initials: E
authors.lastname: Bayraktar
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Aksoy
authors.forename: Mürvet
authors.initials: M
authors.lastname: Başer
authors.forename: Mustafa Oğuz
authors.initials: MO
authors.lastname: Yilmaz
authors.forename: İptisam İpek
authors.initials: İİ
authors.lastname: Müderris
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000698:Analgesia / Q000379:methods; D003475:Curettage / Q000009:adverse effects / Q000379:methods; D004008:Diclofenac / Q000008:administration & dosage*; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008614:Meperidine / Q000008:administration & dosage*; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000473:pathology; D059408:Pain Management / Q000379:methods; D014325:Tromethamine / Q000008:administration & dosage*; D014592:Uterine Hemorrhage / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery
chemical_list: D014325:Tromethamine; D004008:Diclofenac; D000082:Acetaminophen; D007660:Ketoprofen; D008012:Lidocaine; D008614:Meperidine; C118296:dexketoprofen trometamol