title: [Unusual masquerade of an ocular carcinoma metastasis].
abstract: BACKGROUND
  Idiopathic and therapy resistant uveitis especially of unclear origin, is a diagnostic challenge for ophthalmologists. Metastases to the anterior chamber or vitreous body can occasionally mimic the clinical picture of uveitis, a variant on the usual lymphomatous masquerade syndrome. The underlying pathological pathways leading to the metastatic spread of tumor cells within the fluid compartments of the eye remain unclear.
  
  
  METHODS
  We present an unusual case of vitreous metastases to the right eye of a patient in whom an underlying primary malignancy was unknown. After recurrent episodes of cortisone-refractive panuveitis with pseudohypopyon, a diagnostic vitreous biopsy was performed. Cytopathological examination of the vitreous sample revealed carcinoma cells with an immune profile suggestive of lung cancer metastasis. Subsequent staging investigations revealed a primary lung adenocarcinoma as well as cerebral, adrenal and osseous metastases.
  
  
  METHODS
  Due to the extent of dissemination of this non-small cell lung cancer (NSCLC), only palliative treatment including external beam irradiation and systemic chemotherapy was possible to reduce pain and to maintain vision as well as an attempt at systemic control of the disease.
authors.affiliation: Augenklinik, Universitätsaugenklinik Knappschaftskrankenhaus Bochum, Ruhr-Universität Bochum, Bochum, Deutschland. ilan.wunderlich@gmail.com.
authors.forename: M I
authors.initials: MI
authors.lastname: Wunderlich
authors.affiliation: Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, Großbritannien.|Augenklinik Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Berlin, Deutschland.
authors.forename: E J
authors.initials: EJ
authors.lastname: Nissen
authors.affiliation: Augenklinik, Universitätsaugenklinik Knappschaftskrankenhaus Bochum, Ruhr-Universität Bochum, Bochum, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Schargus
authors.affiliation: Augenklinik, Universitätsaugenklinik Knappschaftskrankenhaus Bochum, Ruhr-Universität Bochum, Bochum, Deutschland.
authors.forename: H B
authors.initials: HB
authors.lastname: Dick
authors.affiliation: Medizinische Klinik, Universitätsklinikum Knappschaftskrankenhaus, Ruhr-Universität, Bochum, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Pohl
authors.affiliation: Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, Großbritannien.
authors.forename: S E
authors.initials: SE
authors.lastname: Coupland
authors.affiliation: Augenklinik, Universitätsaugenklinik Knappschaftskrankenhaus Bochum, Ruhr-Universität Bochum, Bochum, Deutschland.
authors.forename: V
authors.initials: V
authors.lastname: Kakkassery
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000556:secondary*; D000368:Aged; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000473:pathology* / Q000556:secondary*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D014605:Uveitis / Q000175:diagnosis; D014822:Vitreous Body / Q000473:pathology*
keywords: Lung cancer; Non-small cell adenocarcinoma; Tumor spread; Uveitis; Vitreous metastasis