title: Copper-Catalyzed Borylative Cross-Coupling of Allenes and Imines: Selective Three-Component Assembly of Branched Homoallyl Amines.
abstract: A copper-catalyzed three-component coupling of allenes, bis(pinacolato)diboron, and imines allows regio-, chemo-, and diastereoselective assembly of branched α,β-substituted-γ-boryl homoallylic amines, that is, products bearing versatile amino, alkenyl, and borane functionality. Alternatively, convenient oxidative workup allows access to α-substituted-β-amino ketones. A computational study has been used to probe the stereochemical course of the cross-coupling.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Rd, Manchester, M13 9PL, UK.
authors.forename: James
authors.initials: J
authors.lastname: Rae
authors.affiliation: School of Chemistry, University of Manchester, Oxford Rd, Manchester, M13 9PL, UK.
authors.forename: Kay
authors.initials: K
authors.lastname: Yeung
authors.affiliation: School of Chemistry, University of Manchester, Oxford Rd, Manchester, M13 9PL, UK.
authors.forename: Joseph J W
authors.initials: JJ
authors.lastname: McDouall
authors.affiliation: School of Chemistry, University of Manchester, Oxford Rd, Manchester, M13 9PL, UK. david.j.procter@manchester.ac.uk.
authors.forename: David J
authors.initials: DJ
authors.lastname: Procter
keywords: allenes; boron; copper; cross-coupling; imines