title: Effects of Two Different Dosages of Sildenafil on Patients With Erectile Dysfunction.
abstract: To investigate the effects of two different dosages of sildenafil on patients with erectile dysfunction (ED), a total of 3,674 patients with ED were recruited to answer questionnaires designed specifically for this study. There were 977 patients in the 50 mg group and there were 2,697 patients in the 100 mg group. Both 50 mg and 100 mg of sildenafil therapy increased the ED patients' average monthly frequency of sexual intercourse, improved erectile function state in self-assessment, and elevated sexual satisfaction and enjoyment. Despite a higher rate of concomitant diseases, patients in the higher dosage of sildenafil group had a better outcome in the average monthly frequency of sexual intercourse and sexual enjoyment compared with those in the lower dosage. Such a study might be helpful for health care providers to choose sildenafil dosage for patients with ED.
authors.affiliation: 1 Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Li
authors.affiliation: 1 Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Bai
authors.affiliation: 1 Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: 1 Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.
authors.forename: Bingbing
authors.initials: B
authors.lastname: Shi
authors.affiliation: 2 Peking University Third Hospital, Beijing, China.
authors.forename: Defeng
authors.initials: D
authors.lastname: Liu
authors.affiliation: 2 Peking University Third Hospital, Beijing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.affiliation: 1 Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Ji
authors.affiliation: 3 Des Moines University, Des Moines, IA, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Davis
authors.affiliation: 4 University of Missouri, Columbia, MO, USA.
authors.forename: Ziwen
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: 3 Des Moines University, Des Moines, IA, USA.|4 University of Missouri, Columbia, MO, USA.
authors.forename: Yujiang
authors.initials: Y
authors.lastname: Fang
mesh_terms: D000328:Adult; D017677:Age Distribution; D004305:Dose-Response Relationship, Drug; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000068677:Sildenafil Citrate / Q000008:administration & dosage*; D011795:Surveys and Questionnaires; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; D000068677:Sildenafil Citrate
keywords: dose; erectile dysfunction; sildenafil; therapeutic effect