title: HIV infection and arterial stiffness among older-adults taking antiretroviral therapy in rural Uganda.
abstract: HIV infection is associated with arterial stiffness, but no studies have assessed this relationship in sub-Saharan Africa. We enrolled 205 participants over 40 years old in Uganda: 105 on antiretroviral therapy for a median of 7 years, and a random sample of 100 age and sex-matched HIV-uninfected controls from the clinic catchment area. The prevalence of arterial stiffness (ankle brachial index  > 1.2) was 33%, 18%, 19% and 2% in HIV+ men, HIV- men, HIV+ women, and HIV- women. In multivariable models adjusted for cardiovascular risk factors, HIV+ individuals had over double the prevalence of arterial stiffness (adjusted prevalence ratio 2.86, 95% confidence interval 1.41-5.79, P = 0.003).
authors.affiliation: aDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital bMassachusetts General Hospital Center for Global Health cHarvard Medical School dDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, USA eFaculty of Internal Medicine, Mbarara University of Science and Technology, Mbarara, Uganda fDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA gUniversity of California, San Francisco, CA, USA hEpicentre Research Base, Mbarara, Uganda iRagon Institute of MGH, MIT and Harvard, Boston, MA, USA jDepartment of Microbiology, Mbarara University of Science and Technology, Mbarara, Uganda.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Siedner
authors.forename: June-Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Ruth Sentongo
authors.initials: RS
authors.lastname: Nakku
authors.forename: Linda
authors.initials: L
authors.lastname: Hemphill
authors.forename: Virginia A
authors.initials: VA
authors.lastname: Triant
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Haberer
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Martin
authors.forename: Yap
authors.initials: Y
authors.lastname: Boum
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Kwon
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Tsai
authors.forename: Peter W
authors.initials: PW
authors.lastname: Hunt
authors.forename: Samson
authors.initials: S
authors.lastname: Okello
authors.forename: David R
authors.initials: DR
authors.lastname: Bangsberg
mesh_terms: D044966:Anti-Retroviral Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active; D050197:Atherosclerosis / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012424:Rural Population; D014454:Uganda / Q000453:epidemiology; D059289:Vascular Stiffness
chemical_list: D044966:Anti-Retroviral Agents