title: Global histone post-translational modifications and cancer: Biomarkers for diagnosis, prognosis and treatment?
abstract: Global alterations in epigenetic landscape are now recognized as a hallmark of cancer. Epigenetic mechanisms such as DNA methylation, histone modifications, nucleosome positioning and non-coding RNAs are proven to have strong association with cancer. In particular, covalent post-translational modifications of histone proteins are known to play an important role in chromatin remodeling and thereby in regulation of gene expression. Further, histone modifications have also been associated with different aspects of carcinogenesis and have been studied for their role in the better management of cancer patients. In this review, we will explore and discuss how histone modifications are involved in cancer diagnosis, prognosis and treatment.
authors.affiliation: Shafqat Ali Khan, Divya Reddy, Sanjay Gupta, Epigenetics and Chromatin Biology Group, Gupta Laboratory, Cancer Research Centre, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai 410210, India.
authors.forename: Shafqat Ali
authors.initials: SA
authors.lastname: Khan
authors.affiliation: Shafqat Ali Khan, Divya Reddy, Sanjay Gupta, Epigenetics and Chromatin Biology Group, Gupta Laboratory, Cancer Research Centre, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai 410210, India.
authors.forename: Divya
authors.initials: D
authors.lastname: Reddy
authors.affiliation: Shafqat Ali Khan, Divya Reddy, Sanjay Gupta, Epigenetics and Chromatin Biology Group, Gupta Laboratory, Cancer Research Centre, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai 410210, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Gupta
keywords: Cancer; Diagnosis; Epigenetics; Histone post-translational modifications; Prognosis; Treatment