title: Left Cardiac Sympathetic Denervation in Patients with CASQ2-Associated Catecholaminergic Polymorphic Ventricular Tachycardia.
abstract: BACKGROUND
  Left cardiac sympathetic denervation (LCSD) was reported to be effective in patients with intractable ryanodine receptor mutation-associated catecholaminergic polymorphic ventricular tachycardia (CPVT).
  
  
  OBJECTIVE
  To report our experience with LCSD in calsequestrin (CASQ2) mutation-associated CPVT.
  
  
  METHODS
  LCSD was performed in three patients with CASQ2 mutation-associated CPVT with symptoms and exercise-induced ventricular arrhythmia despite high dose beta-blocker
  
  
  RESULTS
  None of them experienced symptoms or exercise-induced ventricular arrhythmia after LCSD. However, all had recurrence of symptoms and/or exercise-induced ventricular arrhythmia after 6 months (6-18 months).
  
  
  CONCLUSIONS
  LCSD conferred short-term suppression but less than optimal long-term suppression of exercise-induced ventricular arrhythmia among CASQ2-associated CPVT patients.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Marai
authors.forename: Monther
authors.initials: M
authors.lastname: Boulos
authors.forename: Asaad
authors.initials: A
authors.lastname: Khoury
mesh_terms: D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D002155:Calsequestrin / Q000235:genetics*; D015444:Exercise; D006801:Humans; D008297:Male; D009154:Mutation; D012008:Recurrence; D013562:Sympathectomy / Q000379:methods*; D017180:Tachycardia, Ventricular / Q000235:genetics / Q000601:surgery*; D000098850:Polymorphic Catecholaminergic Ventricular Tachycardia
chemical_list: D000319:Adrenergic beta-Antagonists; D002155:Calsequestrin