title: [New Pathogenetic Concepts and Pharmacological Studies on Adjuvant Therapy in Severe Pneumonia].
abstract: Acute lung injury secondary to pneumonia results from inadequate activation of the innate immune system with hyperinflammation and alveolar-capillary barrier dysfunction. To date, effective strategies for prevention or treatment of acute lung injury in pneumonia besides antibiotics are lacking. In preclinical studies, promising therapeutic targets have been identified and novel strategies demonstrated to protect against lung failure in pneumonia. This review highlights some adjuvant therapeutic strategies for modulation of inflammation and stabilization of lung barrier function in pneumonia.
authors.affiliation: Charité - Universitätsmedizin Berlin, Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie.
authors.forename: J
authors.initials: J
authors.lastname: Lienau
authors.affiliation: Charité - Universitätsmedizin Berlin, Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie.
authors.forename: H
authors.initials: H
authors.lastname: Müller-Redetzky
authors.affiliation: Charité - Universitätsmedizin Berlin, Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie.
authors.forename: N
authors.initials: N
authors.lastname: Suttorp
authors.affiliation: Charité - Universitätsmedizin Berlin, Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie.
authors.forename: M
authors.initials: M
authors.lastname: Witzenrath
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant / Q000379:methods; D019317:Evidence-Based Medicine; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D058990:Molecular Targeted Therapy / Q000379:methods; D018410:Pneumonia, Bacterial / Q000150:complications / Q000276:immunology* / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents