title: Affinity-based release of polymer-binding peptides from hydrogels with the target segments of peptides.
abstract: Peptides with affinities for the target segments of polymer hydrogels were identified by biological screening using phage-displayed peptide libraries, and these peptides exhibited an affinity-based release capability from hydrogels. The results from cell culture assays demonstrated the sustained anticancer effects of the drug-conjugated peptides that were released from the hydrogels.
authors.affiliation: Department of Organic and Polymeric Materials, Tokyo Institute of Technology, 2-12-1-H121 Ookayama, Meguro-ku, Tokyo 152-8550, Japan. serizawa@polymer.titech.ac.jp.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Serizawa
authors.affiliation: Department of Organic and Polymeric Materials, Tokyo Institute of Technology, 2-12-1-H121 Ookayama, Meguro-ku, Tokyo 152-8550, Japan. serizawa@polymer.titech.ac.jp.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Fukuta
authors.affiliation: Department of Organic and Polymeric Materials, Tokyo Institute of Technology, 2-12-1-H121 Ookayama, Meguro-ku, Tokyo 152-8550, Japan. serizawa@polymer.titech.ac.jp.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Date
authors.affiliation: Department of Organic and Polymeric Materials, Tokyo Institute of Technology, 2-12-1-H121 Ookayama, Meguro-ku, Tokyo 152-8550, Japan. serizawa@polymer.titech.ac.jp.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Sawada
mesh_terms: D020100:Hydrogels / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D020100:Hydrogels; D010455:Peptides; D011108:Polymers