title: Risk Assessment of Deoxynivalenol by Revisiting Its Bioavailability in Pig and Rat Models to Establish Which Is More Suitable.
abstract: Due to its toxic properties, high stability, and prevalence, the presence of deoxynivalenol (DON) in the food chain is a major threat to food safety and therefore a health risk for both humans and animals. In this study, experiments were carried out with sows and female rats to examine the kinetics of DON after intravenous and oral administration at 100 µg/kg of body weight. After intravenous administration of DON in pigs, a two-compartment model with rapid initial distribution (0.030 ± 0.019 h) followed by a slower terminal elimination phase (1.53 ± 0.54 h) was fitted to the concentration profile of DON in pig plasma. In rats, a short elimination half-life (0.46 h) and a clearance of 2.59 L/h/kg were estimated by sparse sampling non-compartmental analysis. Following oral exposure, DON was rapidly absorbed and reached maximal plasma concentrations (Cmax) of 42.07 ± 8.48 and 10.44 ± 5.87 µg/L plasma after (t(max)) 1.44 ± 0.52 and 0.17 h in pigs and rats, respectively. The mean bioavailability of DON was 70.5% ± 25.6% for pigs and 47.3% for rats. In the framework of DON risk assessment, these two animal models could be useful in an exposure scenario in two different ways because of their different bioavailability.
authors.affiliation: ANSES, Fougères Laboratory, Antibiotics, Biocides, Residues and Resistance Unit, 10B rue Claude Bourgelat, Javené, CS 40608, Fougères 35306, France. manuel.saint-cyr@anses.fr.
authors.forename: Manuel Jimmy
authors.initials: MJ
authors.lastname: Saint-Cyr
authors.affiliation: ANSES, Fougères Laboratory, Antibiotics, Biocides, Residues and Resistance Unit, 10B rue Claude Bourgelat, Javené, CS 40608, Fougères 35306, France. agnes.perrin-guyomard@anses.fr.
authors.forename: Agnès
authors.initials: A
authors.lastname: Perrin-Guyomard
authors.affiliation: ANSES, Fougères Laboratory, Scientific Support Unit, 10B rue Claude Bourgelat, Javené, CS 40608, Fougères 35306, France. jacqueline.manceau@anses.fr.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Manceau
authors.affiliation: ANSES, Fougères Laboratory, Antibiotics, Biocides, Residues and Resistance Unit, 10B rue Claude Bourgelat, Javené, CS 40608, Fougères 35306, France. pamela.houee@anses.fr.
authors.forename: Paméla
authors.initials: P
authors.lastname: Houée
authors.affiliation: ANSES, Fougères Laboratory, Analysis of Residues and Contaminants Unit, 10B rue Claude Bourgelat, Javené, CS 40608, Fougères 35306, France. jean-michel.delmas@anses.fr.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Delmas
authors.affiliation: ANSES, Fougères Laboratory, Scientific Support Unit, 10B rue Claude Bourgelat, Javené, CS 40608, Fougères 35306, France. jean-guy.rolland@anses.fr.
authors.forename: Jean-Guy
authors.initials: JG
authors.lastname: Rolland
authors.affiliation: ANSES, Fougères Laboratory, Scientific Support Unit, 10B rue Claude Bourgelat, Javené, CS 40608, Fougères 35306, France. michel.laurentie@anses.fr.
authors.forename: Michel
authors.initials: M
authors.lastname: Laurentie
mesh_terms: D061605:Administration, Intravenous; D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D005260:Female; D023421:Models, Animal; D008954:Models, Biological; D019055:No-Observed-Adverse-Effect Level; D017207:Rats, Sprague-Dawley; D018570:Risk Assessment; D013552:Swine; D014255:Trichothecenes / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity*
chemical_list: D014255:Trichothecenes; C007262:deoxynivalenol
keywords: bioavailability; deoxynivalenol; risk assessment; toxicokinetic