title: Interstitial Mycosis Fungoides With Lichen Sclerosus-Like Clinical and Histopathological Features.
abstract: Mycosis fungoides (MF) simulates a variety of dermatologic disorders histopathologically and clinically, well deserving the designation of a great mimicker. Interstitial MF is a rare, but well-recognized histopathological variant resembling the interstitial form of granuloma annulare or the inflammatory phase of morphea. From a clinical standpoint, MF can have a wide array of manifestations, including an anecdotal presentation with lesions clinically suggestive of lichen sclerosus (LS). We herein report a 25-year-old man with a history of patch-stage MF who later developed widespread LS-like lesions histopathologically consistent with interstitial MF. In some biopsies, additional features resembling LS were discerned. We think that our case might represent a unique variant of interstitial MF presenting with LS-like lesions. The diagnostic challenge arising from this uncommon presentation is discussed together with review of the literature.
authors.affiliation: *Department of Dermatology, Marmara University School of Medicine, Istanbul, Turkey; †Kempf und Pfaltz, Histologische Diagnostik, Zürich, Switzerland; and ‡Department of Pathology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Tekin
authors.forename: Werner
authors.initials: W
authors.lastname: Kempf
authors.forename: Dilek
authors.initials: D
authors.lastname: Seckin
authors.forename: Tulin
authors.initials: T
authors.lastname: Ergun
authors.forename: Deniz
authors.initials: D
authors.lastname: Yucelten
authors.forename: Cuyan
authors.initials: C
authors.lastname: Demirkesen
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D018459:Lichen Sclerosus et Atrophicus / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009182:Mycosis Fungoides / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D011237:Predictive Value of Tests; D012867:Skin / Q000737:chemistry / Q000473:pathology*; D012878:Skin Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor