title: Dysbiotic gut microbiome: A key element of Crohn's disease.
abstract: Since the first publication on "regional ileitis", the relevance of this chronic inflammatory disease condition termed finally as Crohn's disease is continuously increasing. Although we are beginning to comprehend certain aspects of its pathogenesis, many facets remain unexplored. Host's gut microbiota is involved in a wide range of physiological and pathological processes including immune system development, and pathogen regulation. Further, the microbiome is thought to play a key role in Crohn's disease. The presence of Crohn's-associated variants of NOD2 and ATG16L genes appears to be associated not only with alterations of mucosal barrier functions, and bacterial killing, but the gut microbiota, as well, reflecting a potential relationship between the host's genotype and intestinal dysbiosis, involved in disease etiology. This review aims to characterize some exciting new aspect of Crohn's disease pathology, focusing mainly on the role of intestinal microbes, and their interplay with the immune system of the host.
authors.affiliation: Faculty of Medicine, Semmelweis University, Szentkirályi Street 46, 1088 Budapest, Hungary. Electronic address: styrkoyri@gmail.com.
authors.forename: Styrk Furnes
authors.initials: SF
authors.lastname: Øyri
authors.affiliation: 2nd Department of Internal Medicine, Semmelweis University, Szentkirályi Street 46, 1088 Budapest, Hungary. Electronic address: muzes.gyorgyi@med.semmelweis-univ.hu.
authors.forename: Györgyi
authors.initials: G
authors.lastname: Műzes
authors.affiliation: 2nd Department of Internal Medicine, Semmelweis University, Szentkirályi Street 46, 1088 Budapest, Hungary. Electronic address: dr.siposf@gmail.com.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Sipos
mesh_terms: D000818:Animals; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins / Q000235:genetics; D003424:Crohn Disease / Q000235:genetics / Q000276:immunology* / Q000382:microbiology*; D004032:Diet; D064806:Dysbiosis / Q000382:microbiology*; D000069196:Gastrointestinal Microbiome / Q000276:immunology* / Q000502:physiology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D007422:Intestines / Q000276:immunology; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics; D019936:Probiotics
chemical_list: C518959:ATG16L1 protein, human; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein
keywords: Crohn's disease; Dysbiosis; Gut microbiome; Immune system; Pathogenesis; Therapeutic aspects