title: Population genetic study of 34 X-Chromosome markers in 5 main ethnic groups of China.
abstract: As a multi-ethnic country, China has some indigenous population groups which vary in culture and social customs, perhaps as a result of geographic isolation and different traditions. However, upon close interactions and intermarriage, admixture of different gene pools among these ethnic groups may occur. In order to gain more insight on the genetic background of X-Chromosome from these ethnic groups, a set of X-markers (18 X-STRs and 16 X-Indels) was genotyped in 5 main ethnic groups of China (HAN, HUI, Uygur, Mongolian, Tibetan). Twenty-three private alleles were detected in HAN, Uygur, Tibetan and Mongolian. Significant differences (p < 0.0001) were all observed for the 3 parameters of heterozygosity (Ho, He and UHe) among the 5 ethnic groups. Highest values of Nei genetic distance were always observed at HUI-Uygur pairwise when analyzed with X-STRs or X-Indels separately and combined. Phylogenetic tree and PCA analyses revealed a clear pattern of population differentiation of HUI and Uygur. However, the HAN, Tibetan and Mongolian ethnic groups were closely clustered. Eighteen X-Indels exhibited in general congruent phylogenetic signal and similar cluster among the 5 ethnic groups compared with 16 X-STRs. Aforementioned results proved the genetic polymorphism and potential of the 34 X-markers in the 5 ethnic groups.
authors.affiliation: Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063, P.R. China.|State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China.
authors.forename: Suhua
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063, P.R. China.
authors.forename: Yingnan
authors.initials: Y
authors.lastname: Bian
authors.affiliation: Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Institute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, P.R.China.
authors.forename: Kuan
authors.initials: K
authors.lastname: Sun
authors.affiliation: Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063, P.R. China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063, P.R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha 410013, P.R. China.
authors.forename: Lagabaiyila
authors.initials: L
authors.lastname: Zha
authors.affiliation: Department of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha 410013, P.R. China.
authors.forename: Jifeng
authors.initials: J
authors.lastname: Cai
authors.affiliation: Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, P.R. China.
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China.
authors.forename: Chaoneng
authors.initials: C
authors.lastname: Ji
authors.affiliation: Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063, P.R. China.
authors.forename: Chengtao
authors.initials: C
authors.lastname: Li
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D041321:Chromosomes, Human, X / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005819:Genetic Markers; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D054643:INDEL Mutation; D010802:Phylogeny; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers