title: Single-item migraine screening tests, self-reported bothersome headache or stripe pattern hypersensitivity?
abstract: BACKGROUND
  A simple screening tool may potentially help the migraine diagnosis in a primary care setting. The use of single-item tests, such as stripe pattern hypersensitivity test and self-reported bothersome headache (HA) question, as migraine screening tools have not been fully explored.
  
  
  METHODS
  Two hundred and fifty-four subjects (patients and companions) were randomly enrolled from an OB/GYN clinic (men 82, women 172; age 38 ± 14). They were instructed to rate the stripe sensitivity level (0-4) and to report any bothersome HA (yes/no). A brief structured HA interview was conducted to describe the HA characteristics and for migraine diagnosis based on the ICHD-IIIβ criteria.
  
  
  RESULTS
  In a multivariate model, bothersome HA question and stripe pattern hypersensitivity test were both significantly associated with EM+PM+CM (odds ratio: 24.0, P < 0.01 vs 2.6, P = 0.01) or EM (odds ratio: 16.2, P < 0.01 vs 3.0, P < 0.01). Bothersome HA question had a greater screening power than stripe pattern hypersensitivity for screening EM+PM+CM (area under the ROC curve: 0.84 [95% CI 0.78-0.89] vs 0.62 [95% CI 0.55-0.69]) or EM (area under the ROC curve: 0.80 [95% CI 0.73-0.86] vs 0.64 [95% CI 0.56-0.72]).
  
  
  CONCLUSIONS
  When performed in an OB/GYN clinic, self-reported bothersome HA question seemed more powerful than visual stripe pattern test in screening migraine thus could potentially be used as a single-item screening test.
authors.affiliation: Jefferson Headache Center, Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: H
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Jefferson Headache Center, Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Hopkins
authors.affiliation: Department of Obstetrics and Gynecology, Einstein Medical Center, Philadelphia, PA, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Goldberg
authors.affiliation: Jefferson Headache Center, Thomas Jefferson University, Philadelphia, PA, USA. Stephen.silberstein@jefferson.edu.
authors.forename: S D
authors.initials: SD
authors.lastname: Silberstein
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D005260:Female; D006261:Headache / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D008881:Migraine Disorders / Q000175:diagnosis*; D010775:Photic Stimulation / Q000009:adverse effects*; D010787:Photosensitivity Disorders / Q000175:diagnosis*; D011247:Pregnancy; D012372:ROC Curve; D055815:Young Adult
keywords: migraine; screening; stripe sensitivity