title: [Association between serotonin transporter and monoamine oxidase A gene polymorphisms and depression].
abstract: BACKGROUND
  Serotonin plays a central role regulating mood and on the development of depressive disorders.
  
  
  OBJECTIVE
  To study whether 5HTTLPR functional polymorphisms in the serotonin transporter gene or the Monoamine oxidase A gene (uMAOA) were risk markers for depression.
  
  
  METHODS
  The Composite International Diagnostic Interview (CIDI) was applied to 1,062 consultants in primary health care centers aged between 18 and 75 years to establish the diagnosis of depression. A sample of saliva was obtained for DNA extraction and genetic analyses.
  
  
  RESULTS
  No association between the presence of depressive disorders and 5HTTLPR (ss) or uMAOA (3/3) risk genotypes was found. Psychological abuse and the presence of two or more life events were found to be predictors of depression in the studied sample.
  
  
  CONCLUSIONS
  In this study, 5HTTLPR and uMAOA polymorphisms were not risk factors for depression. However, psychological abuse and the presence of two or more life events were risk factors for depressive disorders.
authors.forename: Romina
authors.initials: R
authors.lastname: Rojas
authors.forename: Benjamín
authors.initials: B
authors.lastname: Vicente
authors.forename: Sandra
authors.initials: S
authors.lastname: Saldivia
authors.forename: Roberto
authors.initials: R
authors.lastname: Melipillán
authors.forename: Geraldine
authors.initials: G
authors.lastname: Aedo
authors.forename: Naín
authors.initials: N
authors.lastname: Hormazabal
authors.forename: Ana
authors.initials: A
authors.lastname: Carroza
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D003863:Depression / Q000235:genetics* / Q000523:psychology; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011446:Prospective Studies; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012959:Socioeconomic Factors; D013315:Stress, Psychological / Q000150:complications; D055815:Young Adult
chemical_list: D015415:Biomarkers; D050486:Serotonin Plasma Membrane Transport Proteins; D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human