title: Replacing and safeguarding pancreatic β cells for diabetes.
abstract: Pluripotent stem cells are a scalable source of pancreatic cells for transplantation into patients with diabetes. Here, we describe how the field is gaining momentum toward a β cell replacement therapy.
authors.affiliation: Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Bruin
authors.affiliation: BetaLogics Venture, Janssen R & D, Raritan, NJ 08869, USA.
authors.forename: Alireza
authors.initials: A
authors.lastname: Rezania
authors.affiliation: Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. tim.kieffer@ubc.ca.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Kieffer
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D017690:Cell Transplantation; D003920:Diabetes Mellitus / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007107:Immune System; D050417:Insulin-Secreting Cells / Q000166:cytology*; D016381:Islets of Langerhans Transplantation; D051379:Mice; D039904:Pluripotent Stem Cells / Q000166:cytology*
chemical_list: D001786:Blood Glucose