title: External magnetic fields affect the biological impacts of superparamagnetic iron nanoparticles.
abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) are recognized as one of the promising nanomaterials for applications in various field of nanomedicine such as targeted imaging/drug delivery, tissue engineering, hyperthermia, and gene therapy. Besides their suitable biocompatibility, SPIONs' unique magnetic properties make them an outstanding candidate for theranostic nanomedicine. Very recent progress in the field revealed that the presence of external magnetic fields may cause considerable amount of SPIONs' agglomeration in their colloidal suspension. As variation of physicochemical properties of colloidal nanoparticles has strong effect on their biological outcomes, one can expect that the SPIONs' agglomeration in the presence of external magnetic fields could change their well-recognized biological impacts. In this case, here, we probed the cellular uptake and toxicity of the SPIONs before and after exposure to external magnetic fields. We found that the external magnetic fields can affect the biological outcome of magnetic nanoparticles.
authors.affiliation: Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran. Electronic address: shanehsazzadeh@razi.tums.ac.ir.
authors.forename: Saeed
authors.initials: S
authors.lastname: Shanehsazzadeh
authors.affiliation: Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Iran.
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Lahooti
authors.affiliation: The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Hajipour
authors.affiliation: Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen N, Denmark.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Ghavami
authors.affiliation: Nanotechnology Research Center and Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Azhdarzadeh
mesh_terms: D002852:Chromatography, Ion Exchange; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007501:Iron / Q000737:chemistry*; D061986:MCF-7 Cells; D008280:Magnetics; D053768:Metal Nanoparticles; D046529:Microscopy, Electron, Transmission; D000068936:Theranostic Nanomedicine
chemical_list: D007501:Iron
keywords: Aggregation; External magnetic fields; Magnetic nanoparticles; Toxicity