title: Metastatic Adenocarcinoma of Unknown Primary in the Bilateral Cerebellopontine Angles: Case Report and Review of the Literature.
abstract: Metastatic adenocarcinoma in bilateral cerebellopontine angles (CPA) is rare. We report a case and review the current literature in order to enhance recognition of metastatic adenocarcinoma in the cerebellopontine angle. A 44-year-old man was referred to the hospital with rightsided diminished hearing for 7 weeks, left-sided facial palsy for 2 weeks, and left-sided sensorineural hearing loss for 1 week. On Magnetic Resonance Imaging (MRI) two tumors in bilateral CPAs were detected. The left-sided tumor was resected and histopathological examination revealed an adenocarcinoma. Many investigations could not find the primary tumor. One should be careful with middle-aged or elderly patients with sudden progressive deficits in the VIII < sup > th < /sup > or VII < sup > th < /sup > cranial nerves, particularly in bilateral CPA.
authors.affiliation: AIm: Previous studies have shown that carvedilol has a neuroprotective effect in animal models of brain ischemia and brain oxidative damage.
authors.forename: Dao-Bao
authors.initials: DB
authors.lastname: Zhang
authors.forename: Nian-Dong
authors.initials: ND
authors.lastname: Zheng
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000556:secondary*; D000328:Adult; D002528:Cerebellar Neoplasms / Q000556:secondary*; D002530:Cerebellopontine Angle / Q000473:pathology*; D005158:Facial Paralysis / Q000209:etiology; D006319:Hearing Loss, Sensorineural / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009382:Neoplasms, Unknown Primary / Q000473:pathology*