title: Influence of genetic polymorphisms of cytokine genes in the outcome of HLA-matched allogeneic stem cell transplantation in a South East Asian population.
abstract: Non-HLA gene polymorphisms have been shown to be associated with the risk of graft-versus-host disease (GVHD) and outcome of allogeneic haematopoietic stem cell transplantation (AHSCT). This study aims to investigate the role of IL6, TNFα, IL10, IL2 and IL12 gene polymorphisms in the outcome of AHSCT in a South East Asian population. A total of 67 patients and 59 donors who underwent HLA-identical matched sibling AHSCT were available for analysis. There was no significant association between the different cytokine genotypes of patients with the incidence and severity of acute GVHD. Patients with IL2 166∗T allele and patients who received donor stem cells who had IL2 166∗G allele appeared to have reduced incidence of cGVHD. Patients who received donor stem cells with IL12 1188∗C allele are found to be associated with better disease free survival. These results suggest a possible role of IL2 and IL12 gene polymorphisms in the outcome of AHSCT in a South East Asian population.
authors.affiliation: Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia. Electronic address: gangg@ummc.edu.my.
authors.forename: G G
authors.initials: GG
authors.lastname: Gan
authors.affiliation: Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: Y C
authors.initials: YC
authors.lastname: Leong
authors.affiliation: Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: P C
authors.initials: PC
authors.lastname: Bee
authors.affiliation: Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: E F M
authors.initials: EF
authors.lastname: Chin
authors.affiliation: Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: H
authors.initials: H
authors.lastname: Abdul Halim
authors.affiliation: Department of Pathology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
authors.forename: V S
authors.initials: VS
authors.lastname: Nadarajan
authors.affiliation: Subang Jaya Medical Centre, Subang Jaya, Selangor, Malaysia.
authors.forename: A K H
authors.initials: AK
authors.lastname: Teh
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000235:genetics* / Q000502:physiology; D005260:Female; D005838:Genotype; D006086:Graft vs Host Disease / Q000235:genetics*; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics; D007376:Interleukin-2 / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014019:Tissue Donors; D014184:Transplantation, Homologous; D055815:Young Adult
chemical_list: D016207:Cytokines; C508594:IL2 protein, human; D007376:Interleukin-2; D018664:Interleukin-12
keywords: Allogeneic stem cell transplantation; Cytokine gene polymorphism; Graft versus host disease; Interleukin