title: Primary thyroid paraganglioma mimicking medullary thyroid carcinoma: A case report.
abstract: Primary thyroid paraganglioma (TP) is an uncommon tumor, and in rare cases, this disease tends to mimic medullary thyroid carcinoma (MTC). The present study reports a rare case of primary TP mimicking thyroid carcinoma, accompanied by hyperthyroidism. A 30-year-old female presented with an anterior cervical mass. Pre-operative radiological studies and operative frozen section analysis indicated an atypical MTC. Primary TP was finally diagnosed by pathology and immunohistochemical staining. Laboratory examinations (thyroid hormones tests) and Tc99m emission computed tomography revealed hyperthyroidism. Gene analysis of TP-associated gene mutations was negative. Surgical resection was performed as a curative approach and there is currently no metastasis after 36 months of follow-up. Surgeons must be aware of this disease in order to ensure a correct diagnosis and to prevent them from performing unnecessary procedures. The current study presents a case of primary TP mimicking MTC, discusses the radiographic results and histological characteristics, and provides a review of the associated literature.
authors.affiliation: Department of Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China.
authors.forename: Xing
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.affiliation: College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
authors.forename: Cai-Hong
authors.initials: CH
authors.lastname: Ji
authors.affiliation: College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
authors.forename: Chun-DI
authors.initials: CD
authors.lastname: Miao
authors.affiliation: Department of Oncology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China.
authors.forename: Shu
authors.initials: S
authors.lastname: Zheng
keywords: histological characteristics; hyperthyroidism status; medullary thyroid carcinoma; radiographic results; thyroid paraganglioma