title: Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses.
abstract: Combination antiretroviral therapy during primary human immunodeficiency virus-1 infection may enable long-term drug-free virological control in rare individuals. We describe a female who maintained aviremia and a normal CD4(+)/CD8(+) T cell ratio for 10 years after stopping therapy, despite a persistent viral reservoir. Cellular immune responses may have contributed to this outcome.
authors.affiliation: Division of Infection and Immunity , Royal Free Campus, University College London ; Royal Free Hospital , London ; Department of Immunology , University College London Medical School , Royal Free Campus.
authors.forename: Sabine
authors.initials: S
authors.lastname: Kinloch-de Loes
authors.affiliation: Nuffield Department of Medicine ; Oxford National Institute of Health Research Biomedical Research Centre , University of Oxford.
authors.forename: Lucy
authors.initials: L
authors.lastname: Dorrell
authors.affiliation: Nuffield Department of Medicine ; Oxford National Institute of Health Research Biomedical Research Centre , University of Oxford.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Yang
authors.affiliation: Centre for Immunology and Virology , Imperial College London ; Chelsea and Westminster Hospital , London , United Kingdom.
authors.forename: Gareth A D
authors.initials: GA
authors.lastname: Hardy
authors.affiliation: Laboratory of Virology , Geneva University Hospital.
authors.forename: Sabine
authors.initials: S
authors.lastname: Yerly
authors.affiliation: Division of Infection and Immunity , Royal Free Campus, University College London ; Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors.forename: Cristina
authors.initials: C
authors.lastname: Cellerai
authors.affiliation: HIV Translational Research Unit , Ghent University ; University Hospital Ghent , Belgium.
authors.forename: Linos
authors.initials: L
authors.lastname: Vandekerckhove
authors.affiliation: HIV Translational Research Unit , Ghent University ; University Hospital Ghent , Belgium.
authors.forename: Ward
authors.initials: W
authors.lastname: De Spielgelaere
authors.affiliation: HIV Translational Research Unit , Ghent University ; University Hospital Ghent , Belgium.
authors.forename: Eva
authors.initials: E
authors.lastname: Malatinkova
authors.affiliation: Department of Immunology and Molecular Pathology , University College London Medical School , University College London Campus , United Kingdom.
authors.forename: Willie
authors.initials: W
authors.lastname: Wee Lee Koh
authors.affiliation: Division of Infection and Immunity , Royal Free Campus, University College London ; Royal Free Hospital , London.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Johnson
keywords: CD8 T cell; HIV-1 reservoir; antiretroviral therapy; primary HIV-1 infection; viral inhibition assay