title: Calix[8]arene Sulfonic Acid Catalyzed Three-Component Reaction for Convenient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/thiones under Ultrasonic Irradiation.
abstract: In this work, the catalytic activity of calix[8]arene sulfonic acid was successfully investigated for the famous Biginelli reaction. Under ultrasonic irradiation, calix[8]arene sulfonic acid could efficiently catalyzed the three-component reaction of aldehydes with ethyl acetoacetate and urea or thiourea in ethanol to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones/thiones in 46-93%. The advantages of this method are the easy isolated procedure, short reaction time and low cost of the catalyst.
authors.affiliation: Department of Pharmacy, Xuzhou Medical College.
authors.forename: Lin
authors.initials: L
authors.lastname: An
authors.forename: Li-li
authors.initials: LL
authors.lastname: Han
authors.forename: Zu-jian
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Tong-hui
authors.initials: TH
authors.lastname: Huang
authors.forename: Hui-dong
authors.initials: HD
authors.lastname: Zhu
mesh_terms: D047250:Calixarenes / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D013871:Thiones / Q000138:chemical synthesis* / Q000737:chemistry; D014465:Ultrasonics
chemical_list: D013871:Thiones; C500106:calix(8)arenesulfonate; D047250:Calixarenes