title: Utility of Bifunctional N-Heterocyclic Phosphine (NHP)-Thioureas for Metal-Free Carbon-Phosphorus Bond Construction toward Regio- and Stereoselective Formation of Vinylphosphonates.
abstract: An efficient and practical protocol for completely regioselective and highly stereoselective synthesis of vinyldiazaphosphonates from N-heterocyclic phosphine (NHP) and allenes via phospha-Michael/intramolecular nucleophilic substitution reaction has been developed. This transformation enabled the synthesis of valuable densely functionalized vinyldiazaphosphonates with a β-, γ-unsaturated ester moiety under mild reaction conditions. Synthetic utility of vinyldiazaphosphonates was demonstrated by a series of synthetic manipulations.
authors.affiliation: Department of Chemistry and Biochemistry, University of Nevada Las Vegas , 4505 S. Maryland Parkway, Las Vegas, Nevada 89154-4003, United States.
authors.forename: Karimulla
authors.initials: K
authors.lastname: Mulla
authors.affiliation: Department of Chemistry and Biochemistry, University of Nevada Las Vegas , 4505 S. Maryland Parkway, Las Vegas, Nevada 89154-4003, United States.
authors.forename: Kyle L
authors.initials: KL
authors.lastname: Aleshire
authors.affiliation: Department of Chemistry and Biochemistry, University of Nevada Las Vegas , 4505 S. Maryland Parkway, Las Vegas, Nevada 89154-4003, United States.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Forster
authors.affiliation: Department of Chemistry and Biochemistry, University of Nevada Las Vegas , 4505 S. Maryland Parkway, Las Vegas, Nevada 89154-4003, United States.
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Kang