title: Factors associated with diabetes mellitus among adults with tuberculosis in a large European city, 2000-2013.
abstract: BACKGROUND
  Diabetes mellitus (DM) can contribute to the development of tuberculosis (TB).
  
  
  OBJECTIVE
  To analyse the prevalence of DM and its associated factors among adults with TB in a large city in an industrialised country.
  
  
  METHODS
  This is a population-based study in adults diagnosed with TB between 2000 and 2013 in Barcelona. We studied potentially associated sociodemographic and clinical/epidemiological factors. Logistic regression was used to calculate odds ratios (ORs) and their 95% confidence intervals (CIs).
  
  
  RESULTS
  Of 5849 TB patients, 349 (5.9%) had DM. The annual prevalence of DM ranged from 4.0% to 7.2%. Factors associated with DM were being Spanish-born (OR 1.46, 95%CI 1.11-1.96), age ⩾40 years (OR 6.08, 95%CI 4.36-8.66), cavitary patterns on chest X-ray (OR 1.42, 95%CI 1.08-1.86), experiencing more side effects due to anti-tuberculosis treatment (OR 1.86, 95%CI 1.28-2.64) and hospitalisation at the time of diagnosis (OR 1.8, 95%CI 1.40-2.31). Human immunodeficiency virus infection was associated with a lower probability of DM in both subjects with a history of injection drug use (OR 0.27, 95%CI 0.10-0.57) and those without (OR 0.04, 95%CI 0.002-0.19).
  
  
  CONCLUSIONS
  DM prevalence among adults with TB in Barcelona is low and remained stable over the 14-year study period. However, TB patients with DM were potentially more infectious and their clinical management was more complicated.
authors.affiliation: Epidemiology Service, Agència de Salut Pública de Barcelona, Barcelona, Spain; Biomedical Research Consortium of the Epidemiology and Public Health Network (CIBERESP), Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Moreno-Martínez
authors.affiliation: Epidemiology Service, Agència de Salut Pública de Barcelona, Barcelona, Spain; Biomedical Research Consortium of the Epidemiology and Public Health Network (CIBERESP), Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Casals
authors.affiliation: Epidemiology Service, Agència de Salut Pública de Barcelona, Barcelona, Spain; Biomedical Research Consortium of the Epidemiology and Public Health Network (CIBERESP), Barcelona, Spain.
authors.forename: À
authors.initials: À
authors.lastname: Orcau
authors.affiliation: Epidemiology Service, Agència de Salut Pública de Barcelona, Barcelona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Gorrindo
authors.affiliation: Epidemiology Service, Agència de Salut Pública de Barcelona, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Masdeu
authors.affiliation: Epidemiology Service, Agència de Salut Pública de Barcelona, Barcelona, Spain; Biomedical Research Consortium of the Epidemiology and Public Health Network (CIBERESP), Barcelona, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Caylà
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D014376:Tuberculosis / Q000150:complications / Q000453:epidemiology*; D055815:Young Adult