title: Wnt/β-catenin signaling plays a key role in the development of spondyloarthritis.
abstract: Spondyloarthritis (SpA) is a group of diseases consisting of psoriatic arthritis (PsA), reactive arthritis, arthritis related to inflammatory bowel disease (a subgroup of juvenile idiopathic arthritis), and ankylosing spondylitis (the prototype of SpA). Axial bone formation and the combination of concurrent erosion and new bone formation are specific characteristics of SpA disease. The use of antiproinflammatory cytokines, such as inhibitors of tumor necrosis factor α (TNF-α), appears to be the greatest advance in the treatment of SpA over the past 20 years. However, TNF-α blockers do not halt new bone formation. Recent clinical observations and animal studies demonstrate that Wnt signaling proteins and natural Wnt inhibitors, such as DKK1 and sclerostin, are likely to play important roles in the process of ankylosis in SpA, and could potentially serve as therapeutic targets for the treatment of SpA.
authors.affiliation: Department of Biochemistry, Rush University Medical Center, Chicago, Illinois.|Liaoning University of Traditional Chinese Medicine, Shenyang, China.
authors.forename: Wanqing
authors.initials: W
authors.lastname: Xie
authors.affiliation: Department of Biochemistry, Rush University Medical Center, Chicago, Illinois.|Liaoning University of Traditional Chinese Medicine, Shenyang, China.
authors.forename: Lijiang
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Biochemistry, Rush University Medical Center, Chicago, Illinois.
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Biochemistry, Rush University Medical Center, Chicago, Illinois.
authors.forename: Tianqian
authors.initials: T
authors.lastname: Hui
authors.affiliation: Department of Biochemistry, Rush University Medical Center, Chicago, Illinois.
authors.forename: Di
authors.initials: D
authors.lastname: Chen
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D019485:Bone Morphogenetic Proteins / Q000378:metabolism / Q000627:therapeutic use; D016723:Bone Remodeling / Q000187:drug effects; D002358:Cartilage, Articular / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D005819:Genetic Markers; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000209:etiology / Q000517:prevention & control; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism / Q000627:therapeutic use; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D025241:Spondylarthritis / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D025242:Spondylarthropathies / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D060449:Wnt Signaling Pathway / Q000187:drug effects; D051176:beta Catenin / Q000819:agonists* / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000894:Anti-Inflammatory Agents, Non-Steroidal; D019485:Bone Morphogenetic Proteins; C495270:CTNNB1 protein, human; C501126:DKK1 protein, human; D005819:Genetic Markers; D036341:Intercellular Signaling Peptides and Proteins; C422903:SOST protein, human; D051176:beta Catenin
keywords: DKK1; Wnt signaling pathway; Xie, W., L. Zhou, S. Li, et al. 2015. Wnt/β-catenin signaling plays a key role in the development of spondyloarthritis. In “MARROW,” ed. by M. Zaidi. Ann. N.Y. Acad. Sci. 1364: 25-31.; bone formation; sclerostin; spondyloarthritis