title: Parathyroid Hormone-related Peptide-producing Multiple Myeloma and Renal Impairment.
abstract: A 68-year-old man was hospitalized and examined for renal impairment. A laboratory analysis showed hypercalcemia. Although the serum parathyroid hormone and serum 1-25(OH)2 vitamin D3 levels were not elevated, the serum parathyroid hormone-related peptide (PTHrP) level was increased. Immunoelectrophoresis of the urine and bone marrow aspiration indicated multiple myeloma (MM). He was diagnosed with the coexistence of cast nephropathy and light chain deposition disease by a renal biopsy. Notably, PTHrP expression was detected in the myeloma cells based on immunohistochemistry and in situ hybridization. It is therefore important to examine the PTHrP concentration in MM patients with hypercalcemia.
authors.affiliation: Department of Nephrology, Kurashiki Central Hospital, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Kinomura
authors.forename: Noriaki
authors.initials: N
authors.lastname: Shimada
authors.forename: Mana
authors.initials: M
authors.lastname: Nishikawa
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Omori
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Jo
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Ueda
authors.forename: Kenji
authors.initials: K
authors.lastname: Notohara
authors.forename: Riko
authors.initials: R
authors.lastname: Kitazawa
authors.forename: Sohei
authors.initials: S
authors.lastname: Kitazawa
authors.forename: Masaki
authors.initials: M
authors.lastname: Fukushima
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Asano
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D009101:Multiple Myeloma / Q000378:metabolism* / Q000473:pathology; D010281:Parathyroid Hormone / Q000097:blood; D044162:Parathyroid Hormone-Related Protein / Q000378:metabolism*; D051437:Renal Insufficiency / Q000378:metabolism* / Q000473:pathology
chemical_list: C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein