title: Resting-State Cardiac Workload is Related to Both Increased Neocortical Aggregation of Amyloid-β and Relative Impairments in Spatial Working Memory in Pre-Clinical Alzheimer's Disease.
abstract: We sought to determine whether there is any association between a cardiac workload marker, rate pressure product (RPP), working memory, and cortical amyloid-β (Aβ) burden in 63 cognitively normal midlife adults (Mage = 62.8 years; range = 55 to 75 years) at risk for Alzheimer's disease (AD). The results show a small-to-moderate relationship between increasing cardiac workload (at rest) and neocortical amyloidosis in individuals at the preclinical stage of AD. Moreover, increasing RPP was linearly related to increasing relative impairments on a spatial working memory task (R2 = 0.30), but only for those individuals with neuroimaging evidence suggestive of preclinical AD. These results support a relationship between the aggregation of Aβ protein plaques in the neocortex, increased cognitive impairment, and more inefficient myocardial oxygen use in the absence of significant metabolic demands.
authors.affiliation: Interdisciplinary Neuroscience Program, University of Rhode Island, Kingston, RI, USA.
authors.forename: Cláudia Yang
authors.initials: CY
authors.lastname: Santos
authors.affiliation: Department of Neurology, Alpert Medical School of Brown University, Providence, RI, USA.|The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Yen Ying
authors.initials: YY
authors.lastname: Lim
authors.affiliation: Division of Cardiology, Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
authors.forename: Wen-Chih
authors.initials: WC
authors.lastname: Wu
authors.affiliation: Lifespan Biostatistics Core, Lifespan Hospital System, Providence, RI, USA.
authors.forename: Jason Timothy
authors.initials: JT
authors.lastname: Machan
authors.affiliation: Department of Neuroscience, Brown University, Providence, RI, USA.
authors.forename: Shahena
authors.initials: S
authors.lastname: Polynice
authors.affiliation: Pfizer Inc., New York, NY, USA.
authors.forename: Rachel
authors.initials: R
authors.lastname: Schindler
authors.affiliation: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia.|Cogstate Ltd., Melbourne, Victoria, Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: Maruff
authors.affiliation: Interdisciplinary Neuroscience Program, University of Rhode Island, Kingston, RI, USA.|Department of Neurology, Alpert Medical School of Brown University, Providence, RI, USA.
authors.forename: Peter Jeffrey
authors.initials: PJ
authors.lastname: Snyder
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology; D018450:Disease Progression; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D018782:Maze Learning; D008569:Memory Disorders / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D019579:Neocortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D066263:Protein Aggregation, Pathological / Q000209:etiology*; D016526:Workload
chemical_list: D016229:Amyloid beta-Peptides
keywords: Alzheimer’s disease; amyloid beta-peptides; blood pressure; cardiovascular diseases; cerebrovascular disorders; comorbidity; memory; mild cognitive impairment; risk factors; short-term; workload