title: RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease.
authors.affiliation: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom. Electronic address: dewitjelle@gmail.com.
authors.forename: Jelle
authors.initials: J
authors.lastname: de Wit
authors.affiliation: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
authors.forename: M Hussein
authors.initials: MH
authors.lastname: Al-Mossawi
authors.affiliation: Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Hühn
authors.affiliation: Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
authors.forename: Carolina V
authors.initials: CV
authors.lastname: Arancibia-Cárcamo
authors.affiliation: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
authors.forename: Karen
authors.initials: K
authors.lastname: Doig
authors.affiliation: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Kendrick
authors.affiliation: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
authors.forename: Roger
authors.initials: R
authors.lastname: Gundle
authors.affiliation: National Institute for Health Research, Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, University of Oxford, Oxford, United Kingdom.
authors.forename: Peter
authors.initials: P
authors.lastname: Taylor
authors.affiliation: Merck Research Laboratories, Palo Alto, Calif.
authors.forename: Terri
authors.initials: T
authors.lastname: Mcclanahan
authors.affiliation: Merck Research Laboratories, Palo Alto, Calif.
authors.forename: Erin
authors.initials: E
authors.lastname: Murphy
authors.affiliation: Merck Research Laboratories, Boston, Mass.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Merck Research Laboratories, Boston, Mass.
authors.forename: Ken
authors.initials: K
authors.lastname: Barr
authors.affiliation: Merck Research Laboratories, Boston, Mass.
authors.forename: J Richard
authors.initials: JR
authors.lastname: Miller
authors.affiliation: Merck Research Laboratories, Boston, Mass.
authors.forename: Xiao
authors.initials: X
authors.lastname: Hu
authors.affiliation: Lycera Corp, Ann Arbor, Mich.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Aicher
authors.affiliation: Lycera Corp, Ann Arbor, Mich.
authors.forename: Rodney W
authors.initials: RW
authors.lastname: Morgan
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, Mich.
authors.forename: Gary D
authors.initials: GD
authors.lastname: Glick
authors.affiliation: Merck Research Laboratories, Boston, Mass.
authors.forename: Dennis
authors.initials: D
authors.lastname: Zaller
authors.affiliation: Merck Research Laboratories, Boston, Mass.
authors.forename: Craig
authors.initials: C
authors.lastname: Correll
authors.affiliation: Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
authors.forename: Fiona
authors.initials: F
authors.lastname: Powrie
authors.affiliation: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom; National Institute for Health Research, Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, University of Oxford, Oxford, United Kingdom.
authors.forename: Paul
authors.initials: P
authors.lastname: Bowness
mesh_terms: D001168:Arthritis / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007191:Indazoles / Q000737:chemistry / Q000494:pharmacology*; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D020381:Interleukin-17 / Q000096:biosynthesis; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000037:antagonists & inhibitors*; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D058504:Th17 Cells / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism
chemical_list: D007191:Indazoles; D020381:Interleukin-17; C000609599:MRL-248; C000609600:MRL-367; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3