title: C-kit Mutations in Endometrial Cancer: Correlation with Tumor Histologic Type.
abstract: OBJECTIVE
  Endometrial cancer is the fourth most common cancer among women in developed countries. Affected patients may benefit from systemic chemotherapy, alone or in combination with targeted therapies if the disease is clinically diagnosed prior to expansion and metastasis to other organs.The aim of this study was to evaluate the prognostic role of c-kit mutations and comparision with tumor type and grade in human uterine endometrial carcinomas.
  
  
  METHODS
  Seventy five patients with endometrial carcinoma and seventy five normal controls were studied for possible mutations in exon 17 of the c-kit gene using single strand conformational polymorphisms and sequencing.
  
  
  RESULTS
  c-kit mutation in exon 17 appeared to be significantly different between endometrial carcinoma and normal endometrium. The pattern and frequency of the mutations was also shown to be different between tumors from different stages.
authors.affiliation: Women's Reproductive Health Research Center, Tabriz, Iran E-mail : dastranjt@gmail.com.
authors.forename: Taiebeh
authors.initials: T
authors.lastname: Kafshdooz
authors.forename: Seyyed Mojtaba
authors.initials: SM
authors.lastname: Mohaddes Ardabili
authors.forename: Leila
authors.initials: L
authors.lastname: Kafshdooz
authors.forename: Ali Dastranj
authors.initials: AD
authors.lastname: Tabrizi
authors.forename: Morteza
authors.initials: M
authors.lastname: Ghojazadeh
authors.forename: Jalal
authors.initials: J
authors.lastname: Gharesouran
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
mesh_terms: D001483:Base Sequence; D004273:DNA, Neoplasm / Q000235:genetics*; D016889:Endometrial Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology; D004717:Endometrium / Q000473:pathology*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational / Q000235:genetics; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D004273:DNA, Neoplasm; D019009:Proto-Oncogene Proteins c-kit