title: Fat mass- and obesity-associated genotype, dietary intakes and anthropometric measures in European adults: the Food4Me study.
abstract: The interplay between the fat mass- and obesity-associated (FTO) gene variants and diet has been implicated in the development of obesity. The aim of the present analysis was to investigate associations between FTO genotype, dietary intakes and anthropometrics among European adults. Participants in the Food4Me randomised controlled trial were genotyped for FTO genotype (rs9939609) and their dietary intakes, and diet quality scores (Healthy Eating Index and PREDIMED-based Mediterranean diet score) were estimated from FFQ. Relationships between FTO genotype, diet and anthropometrics (weight, waist circumference (WC) and BMI) were evaluated at baseline. European adults with the FTO risk genotype had greater WC (AA v. TT: +1·4 cm; P=0·003) and BMI (+0·9 kg/m2; P=0·001) than individuals with no risk alleles. Subjects with the lowest fried food consumption and two copies of the FTO risk variant had on average 1·4 kg/m2 greater BMI (Ptrend=0·028) and 3·1 cm greater WC (Ptrend=0·045) compared with individuals with no copies of the risk allele and with the lowest fried food consumption. However, there was no evidence of interactions between FTO genotype and dietary intakes on BMI and WC, and thus further research is required to confirm or refute these findings.
authors.affiliation: 1Human Nutrition Research Centre,Institute of Cellular Medicine,Newcastle University,Newcastle Upon Tyne NE1 7RU,UK.
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Livingstone
authors.affiliation: 1Human Nutrition Research Centre,Institute of Cellular Medicine,Newcastle University,Newcastle Upon Tyne NE1 7RU,UK.
authors.forename: Carlos
authors.initials: C
authors.lastname: Celis-Morales
authors.affiliation: 2Center for Nutrition Research,University of Navarra,31008 Pamplona,Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Navas-Carretero
authors.affiliation: 2Center for Nutrition Research,University of Navarra,31008 Pamplona,Spain.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: San-Cristobal
authors.affiliation: 4UCD Institute of Food and Health,University College Dublin,Belfield,Dublin 4,Republic of Ireland.
authors.forename: Hannah
authors.initials: H
authors.lastname: Forster
authors.affiliation: 4UCD Institute of Food and Health,University College Dublin,Belfield,Dublin 4,Republic of Ireland.
authors.forename: Clare B
authors.initials: CB
authors.lastname: O'Donovan
authors.affiliation: 4UCD Institute of Food and Health,University College Dublin,Belfield,Dublin 4,Republic of Ireland.
authors.forename: Clara
authors.initials: C
authors.lastname: Woolhead
authors.affiliation: 5Department of Human Biology,NUTRIM School of Nutrition and Translational Research in Metabolism,Maastricht University Medical Centre,Maastricht 6229 HX,The Netherlands.
authors.forename: Cyril F M
authors.initials: CF
authors.lastname: Marsaux
authors.affiliation: 6Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research,University of Reading,Reading RG6 6AP,UK.
authors.forename: Anna L
authors.initials: AL
authors.lastname: Macready
authors.affiliation: 6Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research,University of Reading,Reading RG6 6AP,UK.
authors.forename: Rosalind
authors.initials: R
authors.lastname: Fallaize
authors.affiliation: 7ZIEL Research Center of Nutrition and Food Sciences,Biochemistry Unit,Technische Universität München,85435 Freising,Germany.
authors.forename: Silvia
authors.initials: S
authors.lastname: Kolossa
authors.affiliation: 8Department of Nutrition and Dietetics,Harokopio University,Kallithea 17671,Greece.
authors.forename: Lydia
authors.initials: L
authors.lastname: Tsirigoti
authors.affiliation: 8Department of Nutrition and Dietetics,Harokopio University,Kallithea 17671,Greece.
authors.forename: Christina P
authors.initials: CP
authors.lastname: Lambrinou
authors.affiliation: 8Department of Nutrition and Dietetics,Harokopio University,Kallithea 17671,Greece.
authors.forename: George
authors.initials: G
authors.lastname: Moschonis
authors.affiliation: 9National Food & Nutrition Institute (IZZ),Warsaw 02903,Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Godlewska
authors.affiliation: 9National Food & Nutrition Institute (IZZ),Warsaw 02903,Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Surwiłło
authors.affiliation: 10Department of Nutrition,Institute of Basic Medical Sciences, Faculty of Medicine,University of Oslo,0372 Oslo,Norway.
authors.forename: Christian A
authors.initials: CA
authors.lastname: Drevon
authors.affiliation: 8Department of Nutrition and Dietetics,Harokopio University,Kallithea 17671,Greece.
authors.forename: Yannis
authors.initials: Y
authors.lastname: Manios
authors.affiliation: 9National Food & Nutrition Institute (IZZ),Warsaw 02903,Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Traczyk
authors.affiliation: 4UCD Institute of Food and Health,University College Dublin,Belfield,Dublin 4,Republic of Ireland.
authors.forename: Eileen R
authors.initials: ER
authors.lastname: Gibney
authors.affiliation: 4UCD Institute of Food and Health,University College Dublin,Belfield,Dublin 4,Republic of Ireland.
authors.forename: Lorraine
authors.initials: L
authors.lastname: Brennan
authors.affiliation: 4UCD Institute of Food and Health,University College Dublin,Belfield,Dublin 4,Republic of Ireland.
authors.forename: Marianne C
authors.initials: MC
authors.lastname: Walsh
authors.affiliation: 6Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research,University of Reading,Reading RG6 6AP,UK.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Lovegrove
authors.affiliation: 2Center for Nutrition Research,University of Navarra,31008 Pamplona,Spain.
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Martinez
authors.affiliation: 5Department of Human Biology,NUTRIM School of Nutrition and Translational Research in Metabolism,Maastricht University Medical Centre,Maastricht 6229 HX,The Netherlands.
authors.forename: Wim H M
authors.initials: WH
authors.lastname: Saris
authors.affiliation: 7ZIEL Research Center of Nutrition and Food Sciences,Biochemistry Unit,Technische Universität München,85435 Freising,Germany.
authors.forename: Hannelore
authors.initials: H
authors.lastname: Daniel
authors.affiliation: 4UCD Institute of Food and Health,University College Dublin,Belfield,Dublin 4,Republic of Ireland.
authors.forename: Mike
authors.initials: M
authors.lastname: Gibney
authors.affiliation: 1Human Nutrition Research Centre,Institute of Cellular Medicine,Newcastle University,Newcastle Upon Tyne NE1 7RU,UK.
authors.forename: John C
authors.initials: JC
authors.lastname: Mathers
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D050154:Adiposity / Q000235:genetics; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D015992:Body Mass Index; D002149:Energy Intake; D005247:Feeding Behavior; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D011795:Surveys and Questionnaires; D055105:Waist Circumference; D044465:White People / Q000235:genetics*
keywords: BMI; Dietary intakes; EI total energy intake; FTO fat mass- and obesity-associated gene; Fat mass- and obesity-associated gene; Fried foods; MD PREDIMED-based Mediterranean diet score; PA physical activity; RCT randomised controlled trial; WC waist circumference