title: Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease.
abstract: Aging is the strongest known risk factor for Alzheimer's disease (AD). With the discovery of the mechanistic target of rapamycin (mTOR) as a critical pathway controlling the rate of aging in mice, molecules at the interface between the regulation of aging and the mechanisms of specific age-associated diseases can be identified. We will review emerging evidence that mTOR-dependent brain vascular dysfunction, a universal feature of aging, may be one of the mechanisms linking the regulation of the rate of aging to the pathogenesis of Alzheimer's disease. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.
authors.affiliation: Department of Physiology and the Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio. Electronic address: galvanv@uthscsa.edu.
authors.forename: Veronica
authors.initials: V
authors.lastname: Galvan
authors.affiliation: Department of Biochemistry, University of Texas Health Science Center at San Antonio.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Hart
mesh_terms: D000375:Aging; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D006801:Humans; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D058570:TOR Serine-Threonine Kinases
keywords: Aging; Alzheimer's; Geroscience; MTOR; Neurovascular aging; Target of rapamycin