title: Zinc Chloride and Zinc Acetate Injected into the Neostriatum Produce Opposite Effect on Locomotor Behavior of Rats.
abstract: Zinc chloride and zinc acetate solutions injected in a dose of 1 μg into the rostral neostriatum produced opposite effect on locomotor behavior of rats. Zink chloride disturbed conditioned avoidance and reduced spontaneous motor activity. Zink acetate virtually did not modify avoidance behavior and stimulated motor activity with elements of motor stereotypy. It was hypothesized that important factors here were the relationship between the effect and the level of metal released after salt dissociation and different reactivity of the synaptic substrate of the neostriatum to the presence of zinc ions.
authors.affiliation: Laboratory of Motor Behavior Physiology and Pathology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia. jakim2010@gmail.com.|Laboratory of Higher Nervous Activity Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. jakim2010@gmail.com.
authors.forename: A F
authors.initials: AF
authors.lastname: Yakimovskii
authors.affiliation: Laboratory of Motor Behavior Physiology and Pathology, I. P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia.
authors.forename: S Yu
authors.initials: SY
authors.lastname: Kryzhanovskaya
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D017072:Neostriatum / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D019345:Zinc Acetate / Q000494:pharmacology*; D017967:Zinc Compounds / Q000494:pharmacology*
chemical_list: D002712:Chlorides; D017967:Zinc Compounds; C016837:zinc chloride; D019345:Zinc Acetate
keywords: avoidance behavior; neostriatum; spontaneous motor activity; zinc