title: New Concepts in Complex Regional Pain Syndrome.
abstract: Despite the severe pain and disability associated with complex regional pain syndrome (CRPS), the lack of understanding of the pathophysiological mechanisms supporting this enigmatic condition prevents the rational design of new therapies, a situation that is frustrating to both the physician and the patient. The review highlights some of the mechanisms thought to be involved in the pathophysiology of CRPS in preclinical models and CRPS patients, with the ultimate goal that understanding these mechanisms will lead to the design of efficacious, mechanism-based treatments available to the clinic.
authors.affiliation: Anesthesia Service, Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA; Department of Anesthesiology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
authors.forename: Maral
authors.initials: M
authors.lastname: Tajerian
authors.affiliation: Anesthesia Service, Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA; Department of Anesthesiology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA. Electronic address: djclark@stanford.edu.
authors.forename: John David
authors.initials: JD
authors.lastname: Clark
mesh_terms: D000818:Animals; D020918:Complex Regional Pain Syndromes / Q000503:physiopathology* / Q000628:therapy; D004185:Disability Evaluation; D004195:Disease Models, Animal; D006801:Humans; D059408:Pain Management; D010147:Pain Measurement
keywords: Autoimmunity; Basic mechanisms; CNS plasticity; Complex regional pain syndrome; Disease progression; Neuroinflammation; Preclinical models