title: Adaptive immune regulation in autoimmune diabetes.
abstract: Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the loss of insulin-producing pancreatic β-cells. The pathogenesis of T1D is complex and multifactorial and involves a genetic susceptibility that predisposes to abnormal immune responses in the presence of ill-defined environmental insults to the pancreatic islets. This review discusses how adaptive immunoregulatory T cells contribute to the modulation of the development and evolution of T1D, together with potential approaches that target these cells for new therapies in the disease.
authors.affiliation: Department of Medicine, University of California Los Angeles, 1000 Veteran Avenue 32-59, Los Angeles, CA 90095-1670, USA.
authors.forename: Concetta
authors.initials: C
authors.lastname: Ferretti
authors.affiliation: Department of Medicine, University of California Los Angeles, 1000 Veteran Avenue 32-59, Los Angeles, CA 90095-1670, USA. Electronic address: alacava@mednet.ucla.edu.
authors.forename: Antonio
authors.initials: A
authors.lastname: La Cava
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007515:Islets of Langerhans / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
keywords: Regulatory T-cell immunotherapy; Type 1 diabetes; β-Cells