title: Adjuvant hypofractionated partial-brain radiation therapy for pediatric Ewing sarcoma brain metastases: case report.
abstract: This case report demonstrates that hypofractionated partial-brain radiation therapy with limited margins is a reasonable approach following gross tumor resection of Ewing sarcoma metastases to the brain. The patient presented with 2 intracranial metastases treated with gross-total resection followed by radiation therapy to 30 Gy in 5 fractions. The patient experienced symptomatic treatment-related inflammatory changes with resolution after receiving dexamethasone. He remains alive at 21 months of follow-up with no evidence of disease.
authors.affiliation: Departments of 1 Therapeutic Radiology.
authors.forename: Ritchell
authors.initials: R
authors.lastname: van Dams
authors.affiliation: Departments of 1 Therapeutic Radiology.
authors.forename: Henry S
authors.initials: HS
authors.lastname: Park
authors.affiliation: Pathology.
authors.forename: Ahmed K
authors.initials: AK
authors.lastname: Alomari
authors.affiliation: Neurosurgery, Section of Pediatric Neurosurgery, and.
authors.forename: Adele S
authors.initials: AS
authors.lastname: Ricciardi
authors.affiliation: Pediatrics, Section of Pediatric Hematology and Oncology, Yale School of Medicine, New Haven, Connecticut.
authors.forename: Harini
authors.initials: H
authors.lastname: Rao
authors.affiliation: Pediatrics, Section of Pediatric Hematology and Oncology, Yale School of Medicine, New Haven, Connecticut.
authors.forename: Joseph
authors.initials: J
authors.lastname: McNamara
authors.affiliation: Neurosurgery, Section of Pediatric Neurosurgery, and.|Pediatrics, Section of Pediatric Hematology and Oncology, Yale School of Medicine, New Haven, Connecticut.
authors.forename: Michael L
authors.initials: ML
authors.lastname: DiLuna
authors.affiliation: Departments of 1 Therapeutic Radiology.|Pathology.
authors.forename: Ranjit S
authors.initials: RS
authors.lastname: Bindra
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D002648:Child; D006801:Humans; D008297:Male; D000069473:Radiation Dose Hypofractionation; D018714:Radiotherapy, Adjuvant / Q000379:methods*; D012512:Sarcoma, Ewing / Q000473:pathology*
keywords: Ewing sarcoma; GTR = gross-total resection; WBRT = whole-brain radiation therapy; brain metastases; oncology; radiation necrosis; radiation therapy