title: Tuning innate immunity by translation.
abstract: In multicellular organisms, the epithelia is a contact surface with the surrounding environment and is exposed to a variety of adverse biotic (pathogenic) and abiotic (chemical) factors. Multi-layered pathways that operate on different time scales have evolved to preserve cellular integrity and elicit stress-specific response. Several stress-response programs are activated until a complete elimination of the stress is achieved. The innate immune response, which is triggered by pathogenic invasion, is rather harmful when active over a prolonged time, thus the response follows characteristic oscillatory trajectories. Here, we review different translation programs that function to precisely fine-tune the time at which various components of the innate immune response dwell between active and inactive. We discuss how different pro-inflammatory pathways are co-ordinated to temporally offset single reactions and to achieve an optimal balance between fighting pathogens and being less harmful for healthy cells.
authors.affiliation: Biochemistry and Molecular Biology, Dept. of Chemistry and Biochemistry, University of Hamburg, Hamburg 20146, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Rauscher
authors.affiliation: Biochemistry and Molecular Biology, Dept. of Chemistry and Biochemistry, University of Hamburg, Hamburg 20146, Germany zoya.ignatova@chemie.uni-hamburg.de.
authors.forename: Zoya
authors.initials: Z
authors.lastname: Ignatova
mesh_terms: D056704:Adaptive Immunity / Q000235:genetics / Q000276:immunology*; D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology*; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D008957:Models, Genetic; D018448:Models, Immunological; D014176:Protein Biosynthesis / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*
chemical_list: D018836:Inflammation Mediators; D007371:Interferon-gamma
keywords: infection; inflammation; interferons; interleukins; translation; translation initiation