title: Staphylococcus aureus vs. Osteoblast: Relationship and Consequences in Osteomyelitis.
abstract: Bone cells, namely osteoblasts and osteoclasts work in concert and are responsible for bone extracellular matrix formation and resorption. This homeostasis is, in part, altered during infections by Staphylococcus aureus through the induction of various responses from the osteoblasts. This includes the over-production of chemokines, cytokines and growth factors, thus suggesting a role for these cells in both innate and adaptive immunity. S. aureus decreases the activity and viability of osteoblasts, by induction of apoptosis-dependent and independent mechanisms. The tight relationship between osteoclasts and osteoblasts is also modulated by S. aureus infection. The present review provides a survey of the relevant literature discussing the important aspects of S. aureus and osteoblast interaction as well as the ability for antimicrobial peptides to kill intra-osteoblastic S. aureus, hence emphasizing the necessity for new anti-infectious therapeutics.
authors.affiliation: EA 4691 Biomatériaux et inflammation en site osseux, Pôle Santé, Université de Reims Champagne-Ardenne Reims, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Josse
authors.affiliation: EA 4691 Biomatériaux et inflammation en site osseux, Pôle Santé, Université de Reims Champagne-Ardenne Reims, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Velard
authors.affiliation: EA 4691 Biomatériaux et inflammation en site osseux, Pôle Santé, Université de Reims Champagne-Ardenne Reims, France.
authors.forename: Sophie C
authors.initials: SC
authors.lastname: Gangloff
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D017209:Apoptosis; D002470:Cell Survival; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D050296:Microbial Viability / Q000187:drug effects; D010006:Osteoblasts / Q000276:immunology / Q000382:microbiology* / Q000502:physiology; D010010:Osteoclasts / Q000382:microbiology / Q000502:physiology; D010019:Osteomyelitis / Q000382:microbiology* / Q000473:pathology*; D013203:Staphylococcal Infections / Q000382:microbiology* / Q000473:pathology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000276:immunology / Q000502:physiology*
chemical_list: D023181:Antimicrobial Cationic Peptides
keywords: Staphylococcus aureus; antibiotics; antimicrobial peptide; inflammation; internalization; osteoblast; phenol soluble modulin; small colony variants