title: Recent Advances in BLV Research.
abstract: Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.
authors.affiliation: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), Liège 4000, Belgium. epy.barez@doct.ulg.ac.be.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Barez
authors.affiliation: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), Liège 4000, Belgium. alix.debrogniez@ulg.ac.be.
authors.forename: Alix
authors.initials: A
authors.lastname: de Brogniez
authors.affiliation: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), Liège 4000, Belgium. a.carpentier@doct.ulg.ac.be.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Carpentier
authors.affiliation: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), Liège 4000, Belgium. helene.gazon@ulg.ac.be.
authors.forename: Hélène
authors.initials: H
authors.lastname: Gazon
authors.affiliation: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), Liège 4000, Belgium. n.gillet@ulg.ac.be.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gillet
authors.affiliation: Instituto de Virología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA, Castelar C.C. 1712, Argentina. gutierrez.geronimo@inta.gob.ar.
authors.forename: Gerónimo
authors.initials: G
authors.lastname: Gutiérrez
authors.affiliation: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), Liège 4000, Belgium. mhamaidia@ulg.ac.be.
authors.forename: Malik
authors.initials: M
authors.lastname: Hamaidia
authors.affiliation: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), Liège 4000, Belgium. jacques.jeanrock@gmail.com.
authors.forename: Jean-Rock
authors.initials: JR
authors.lastname: Jacques
authors.affiliation: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), Liège 4000, Belgium. Srikanthperike@gmail.com.
authors.forename: Srikanth
authors.initials: S
authors.lastname: Perike
authors.affiliation: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), Liège 4000, Belgium. sathy.ns@gmail.com.
authors.forename: Sathya
authors.initials: S
authors.lastname: Neelature Sriramareddy
authors.affiliation: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), Liège 4000, Belgium. nrenotte@ulg.ac.be.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Renotte
authors.affiliation: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), Liège 4000, Belgium. b.staumont@doct.ulg.ac.be.
authors.forename: Bernard
authors.initials: B
authors.lastname: Staumont
authors.affiliation: Department of Pathology, National Veterinary Research Institute, Pulawy 24-110, Poland. reichert@piwet.pulawy.pl.
authors.forename: Michal
authors.initials: M
authors.lastname: Reichert
authors.affiliation: Instituto de Virología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA, Castelar C.C. 1712, Argentina. trono.karina@inta.gob.ar.
authors.forename: Karina
authors.initials: K
authors.lastname: Trono
authors.affiliation: Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), Liège 4000, Belgium. luc.willems@ulg.ac.be.
authors.forename: Luc
authors.initials: L
authors.lastname: Willems
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends; D004195:Disease Models, Animal; D054884:Host-Pathogen Interactions; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D001909:Leukemia Virus, Bovine / Q000472:pathogenicity / Q000502:physiology*; D014773:Virology / Q000639:trends
keywords: BLV; HDAC; HTLV-1; Tax; microRNA; vaccine