title: Overweight Is a Major Contributor to Atherosclerosis in Systemic Lupus Erythematosus Patients at Apparent Low Risk for Cardiovascular Disease: A Cross-Sectional Controlled Study.
abstract: Cardiovascular disease (CVD) is the main cause of death in systemic lupus erythematosus (SLE) patients. We aimed to determine whether overweight (defined as a body mass index [BMI] > 25 kg/m(2)) contributed to subclinical atherosclerosis in SLE patients at low risk for CVD according to traditional factors. Wall thickness of the internal carotid artery (ICWT) measured at the carotid bulb and carotid plaques were assessed in 49 SLE patients asymptomatic for CVD and 49 controls matched on Framingham score. Factors associated to ICWT were identified and multivariate analysis was performed.SLE patients and controls displayed a low 10-year risk for CVD according to Framingham score (mean 1.9 ± 3.5 in SLE vs 1.8 ± 3.2% in controls, P = 0.37). ICWT (P < 0.001) and number of patients with carotid plaques (P = 0.015) were, however, higher in SLE patients as compared to controls. In multivariable analysis, SLE was an independent risk for a carotid atherosclerosis (OR [95% confidence interval, CI]: 3.53 [1.36-9.14]; P = 0.009). Older age, higher BMI, and higher Framingham score were associated with atherosclerosis in SLE patients in univariate analysis. In multivariate analysis, only the association with overweight remained significant (OR [95% CI]: 4.13 [1.02-16.75]; P = 0.047). Overweight is a major contributor to atherosclerosis in SLE patients at apparent low risk for CVD.
authors.affiliation: From the Département de Médecine Interne, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, Paris, France (KS, M-PC, TP); INSERM U1149, Paris, France (KS, TP); Département Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodelling in Renal and Respiratory Diseases), Paris, France (KS, TP); Département de Physiologie, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, INSERM U1138, Paris, France (BE); INSERM UMRS970, Paris Cardiovascular Research Center, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Département de Génétique, Paris, France (M-CZ); and Département d'Anesthésie-Réanimation, Hôpitaux Universitaires Saint Louis-Lariboisière, 2 UMR-S 942, INSERM, 3 Université Paris Diderot, Paris, France (EG).
authors.forename: Karim
authors.initials: K
authors.lastname: Sacre
authors.forename: Brigitte
authors.initials: B
authors.lastname: Escoubet
authors.forename: Maria-Christina
authors.initials: MC
authors.lastname: Zennaro
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Chauveheid
authors.forename: Etienne
authors.initials: E
authors.lastname: Gayat
authors.forename: Thomas
authors.initials: T
authors.lastname: Papo
mesh_terms: D000328:Adult; D000367:Age Factors; D050197:Atherosclerosis / Q000453:epidemiology*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002340:Carotid Artery Diseases / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000453:epidemiology*; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D017539:Tunica Intima
chemical_list: D008055:Lipids