title: HIGH-MOBILITY GROUP BOX 1 IN ALLERGIC AND NON ALLERGIC UPPER AIRWAY INFLAMMATION.
abstract: High mobility group box 1, an evolutionary ancient protein conserved in the eukaryotic kingdom, exerts intra- and extra- cellular functions, orchestrating a homeostatic defensive response in challenged tissues. Its action associated with various inflammatory cells is essential for the occurrence, progression, and persistence of asthma, rhinitis, and nasal polyposis. The recent discovery of High mobility group box 1, as a critical mediator of inflammation, stimulated an increasing interest in the field of inflammation research, suggesting new therapies for atopic and non-atopic inflammatory processes.
authors.affiliation: Department of Pediatric Sciences, Unit of Pediatric Genetics and Immunology, University of Messina, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Chirico
authors.affiliation: Department of Internal Medicine, University of Messina, Messina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Lacquaniti
authors.affiliation: Department of Pediatric Sciences, Unit of Pediatric Genetics and Immunology, University of Messina, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Vinci
authors.affiliation: Department of Pediatric Sciences, Unit of Pediatric Genetics and Immunology, University of Messina, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Piraino
authors.affiliation: Department of Pediatric Sciences, Unit of Pediatric Genetics and Immunology, University of Messina, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Manti
authors.affiliation: Department of Pediatric Sciences, Unit of Pediatric Genetics and Immunology, University of Messina, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Marseglia
authors.affiliation: Department of Pediatric Sciences, Unit of Pediatric Genetics and Immunology, University of Messina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Salpietro
authors.affiliation: Department of Pediatric Sciences, Unit of Pediatric Genetics and Immunology, University of Messina, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Gitto
authors.affiliation: Department of Pediatric Sciences, Unit of Pediatric Genetics and Immunology, University of Messina, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Arrigo
authors.affiliation: Department of Pediatric Sciences, Unit of Pediatric Genetics and Immunology, University of Messina, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Salpietro
authors.affiliation: Department of Pediatric Sciences, Unit of Pediatric Genetics and Immunology, University of Messina, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Cuppari