title: CMV-associated axonal sensory-motor Guillain-Barré syndrome in a child: Case report and review of the literature.
abstract: BACKGROUND
  Guillain-Barré syndrome is the most frequent cause of flaccid paresis in Western countries. Moreover, CMV infection is the most common antecedent viral infection in adult patients and the presence of specific IGM antiganglioside antibodies is often identified. Instead, Guillain-Barré syndrome following CMV infections is rarely reported in childhood and often presents severe symptoms at onset and longer recovery times.
  
  
  METHODS
  One year of clinical, electrophysiological and serological follow-up of a 9-year old child with axonal sensory-motor Guillain-Barré syndrome following CMV infection is reported. Moreover, the literature data on paediatric sensory-motor axonal GBS and GBS secondary to CMV infection and antiganglioside antibodies are reviewed.
  
  
  RESULTS
  Our patient presented with paraesthesias and a pattern of weakness showing proximal predominance and affecting the upper limbs more than the lower limbs. At nadir, unilateral facial palsy was also present and he was unable to walk. Electroneurography showed motor-sensory axonal damage. Both anti-CMV and anti-GM2 IgM were positive. After early treatment with IVIG and IV methylprednisolone the patient recovered deambulation. Six months later, his neurological examination was normal and electroneurography showed normal data.
  
  
  CONCLUSIONS
  The sensory-motor axonal form of Guillain-Barré syndrome following CMV infection may present a good prognosis and a prompt full recovery also in children, if adequate treatment is started in time.
authors.affiliation: Child Neuropsychiatry Unit, Santa Maria Nuova Hospital, viale Risorgimento 80, 42123 Reggio Emilia, Italy. Electronic address: carlotta.spagnoli@asmn.re.it.
authors.forename: Carlotta
authors.initials: C
authors.lastname: Spagnoli
authors.affiliation: Child Neuropsychiatry Unit, Santa Maria Nuova Hospital, viale Risorgimento 80, 42123 Reggio Emilia, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Iodice
authors.affiliation: Child Neuropsychiatry Unit, Santa Maria Nuova Hospital, viale Risorgimento 80, 42123 Reggio Emilia, Italy.
authors.forename: Grazia Gabriella
authors.initials: GG
authors.lastname: Salerno
authors.affiliation: Child Neuropsychiatry Unit, Santa Maria Nuova Hospital, viale Risorgimento 80, 42123 Reggio Emilia, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Frattini
authors.affiliation: Child Neuropsychiatry Unit, Santa Maria Nuova Hospital, viale Risorgimento 80, 42123 Reggio Emilia, Italy.
authors.forename: Gianna
authors.initials: G
authors.lastname: Bertani
authors.affiliation: Child Neuropsychiatry Unit, Neuroscience Department, University of Parma, via Gramsci 14, 43126 Parma, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Pisani
authors.affiliation: Child Neuropsychiatry Unit, Santa Maria Nuova Hospital, viale Risorgimento 80, 42123 Reggio Emilia, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Fusco
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000914:Antibodies, Viral / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000097:blood; D002648:Child; D003586:Cytomegalovirus Infections / Q000150:complications*; D005678:G(M2) Ganglioside / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D000914:Antibodies, Viral; D001323:Autoantibodies; D001324:Autoantigens; D016756:Immunoglobulins, Intravenous; D005678:G(M2) Ganglioside; D008775:Methylprednisolone
keywords: Children; Cytomegalovirus; Guillain–Barré syndrome; Sensory-motor axonal