title: Retroperitoneal and mediastinal follicular dendritic cell sarcoma: report of 3 cases with review of literature.
abstract: Follicular dendritic cell sarcoma (FDCS) is a rare malignant histiocytic proliferation of antigen presenting follicular dendritic cell. It is an uncommon primary malignancy first described by Monda et al. in 1986. Most commonly reported cases are lymph nodal. Occasional cases occur in extra nodal sites. Here, we describe the clinicopathological features, histomorphology and outcome of three patients with extranodal FDCS along with a concise review of literature on the topic. All three patients were adult females. Two patients were in third decade, and one had age of 50 years. Among the three cases, two cases are presented as retroperitoneal mass and one as mediastinal mass. CT scans revealed heterogeneously enhancing masses. All the cases showed ovoid to spindle neoplastic cells arranged predominantly in whorling, fascicular and storiform patterns with inflammatory infiltrate. Immunohistochemically, the tumor cells are positive for CD21, CD23, CD35 and Clustrin. In view of rarity and variable clinical presentation in FDCS, accurate diagnosis is necessary. Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: Departments of Pathology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Suvendu
authors.initials: S
authors.lastname: Purkait
authors.affiliation: Departments of Pathology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Saumyaranjan
authors.initials: S
authors.lastname: Mallick
authors.affiliation: Departments of Pathology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Prashant P
authors.initials: PP
authors.lastname: Joshi
authors.affiliation: Department of Radiation, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Supriyo
authors.initials: S
authors.lastname: Mallick
authors.affiliation: Department of Surgery, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: N Vijaya
authors.initials: NV
authors.lastname: Murugan
authors.affiliation: Departments of Pathology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Meher C
authors.initials: MC
authors.lastname: Sharma
authors.affiliation: Departments of Pathology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Vaishali
authors.initials: V
authors.lastname: Suri
authors.affiliation: Oncology and Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Biplab
authors.initials: B
authors.lastname: Mishra
authors.affiliation: Departments of Pathology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Sandeep R
authors.initials: SR
authors.lastname: Mathur
mesh_terms: D000328:Adult; D001706:Biopsy; D003131:Combined Modality Therapy; D054740:Dendritic Cell Sarcoma, Follicular / Q000175:diagnosis* / Q000628:therapy; D003952:Diagnostic Imaging; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000628:therapy; D008875:Middle Aged; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis* / Q000628:therapy; D016896:Treatment Outcome; D055815:Young Adult
keywords: follicular dendritic cell sarcoma; mediastinum; retroperitoneum