title: Pressure-induced isomorphic sclerodermoid graft-versus-host disease from brassiere underwire and tight-fitting watch.
abstract: Sclerodermoid chronic graft-versus-host disease (scGVHD) is a rare form of cGVHD with an estimated prevalence of 3% to 11% in patients receiving allogeneic bone marrow transplants. scGVHD is believed to be an immune-mediated response characterized by aberrant T-cell function and dysregulation of tyrosine kinase cascades. Published literature on scGVHD is still limited and the mechanisms are yet to be fully understood. Thus, successful treatment of scGVHD remains largely unknown and many current options are hindered by potential side effects. This case provides an example of scGVHD localizing to areas of trauma and friction as a potential mechanism behind scGVHD and provides several case reports that document similar findings.
authors.affiliation: University of Kansas Medical Center. cnielson@kumc.edu.
authors.forename: Colton
authors.initials: C
authors.lastname: Nielson
authors.forename: Garth R
authors.initials: GR
authors.lastname: Fraga
authors.forename: Ryan
authors.initials: R
authors.lastname: Fischer
authors.forename: Anand
authors.initials: A
authors.lastname: Rajpara
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003020:Clothing; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D055498:Jewelry; D011241:Prednisone / Q000627:therapeutic use; D011312:Pressure / Q000009:adverse effects*; D012594:Scleroderma, Localized / Q000188:drug therapy / Q000209:etiology*; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D000893:Anti-Inflammatory Agents; D011241:Prednisone