title: One-Year Clinical and Computed Tomography Angiographic Outcomes After Bioresorbable Vascular Scaffold Implantation During Primary Percutaneous Coronary Intervention for ST-Segment-Elevation Myocardial Infarction: The PRAGUE-19 Study.
abstract: BACKGROUND
  Bioresorbable vascular scaffolds (BVS) represent promising new technology, but data on their long-term outcomes in ST-segment-elevation myocardial infarction (STEMI) setting are missing. The aim was to analyze 1-year clinical and computed tomographic angiographic outcomes after BVS implantation in STEMI.
  
  
  RESULTS
  PRAGUE-19 is a prospective multicenter single-arm study enrolling consecutive STEMI patients undergoing primary percutaneous coronary intervention (pPCI) with intention-to-implant BVS. A total of 343 STEMI patients were screened during 15 months enrollment period, and 70 patients (mean age 58.6±10.3 and 74% males) fulfilled entry criteria and BVS was successfully implanted in 96% of them. All patients were invited for clinical and computed tomographic angiographic control 1 year after BVS implantation. Restenosis was defined as ≥75% area stenosis within the scaffolded segment. Three events were potentially related to BVS: 1 in-stent restenosis (treated 7 months after pPCI with drug-eluting balloon), 1 stent thrombosis (treated 2 weeks after pPCI by balloon dilatation-this patient stopped all medications after pPCI), and 1 sudden death at home 9 months after pPCI. Four other patients had events definitely unrelated to BVS. Overall, 1-year mortality was 2.9%. Computed tomographic angiography after 1 year was performed in 59 patients. All BVS were widely patent, and binary restenosis rate was 2% (the only restenosis mentioned above). Mean in-scaffold minimal luminal area was 7.8±2.6 mm(2), area stenosis was 20.1±16.3%, minimal luminal diameter was 3.0±0.6 mm, and diameter stenosis was 12.8±11.1%.
  
  
  CONCLUSIONS
  BVS implantation in STEMI is feasible and safe and offers excellent 1-year clinical and angiographic outcomes.
authors.affiliation: From the Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); Department of Cardiology, University Hospital Kralovske Vinohrady, Prague (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); and Department of Cardiology, Central Military Hospital, Prague, Czech Republic (M.M., J.V., M.H.). petr.widimsky@fnkv.cz.
authors.forename: Petr
authors.initials: P
authors.lastname: Widimsky
authors.affiliation: From the Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); Department of Cardiology, University Hospital Kralovske Vinohrady, Prague (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); and Department of Cardiology, Central Military Hospital, Prague, Czech Republic (M.M., J.V., M.H.).
authors.forename: Robert
authors.initials: R
authors.lastname: Petr
authors.affiliation: From the Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); Department of Cardiology, University Hospital Kralovske Vinohrady, Prague (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); and Department of Cardiology, Central Military Hospital, Prague, Czech Republic (M.M., J.V., M.H.).
authors.forename: Petr
authors.initials: P
authors.lastname: Tousek
authors.affiliation: From the Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); Department of Cardiology, University Hospital Kralovske Vinohrady, Prague (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); and Department of Cardiology, Central Military Hospital, Prague, Czech Republic (M.M., J.V., M.H.).
authors.forename: Martin
authors.initials: M
authors.lastname: Maly
authors.affiliation: From the Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); Department of Cardiology, University Hospital Kralovske Vinohrady, Prague (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); and Department of Cardiology, Central Military Hospital, Prague, Czech Republic (M.M., J.V., M.H.).
authors.forename: Hana
authors.initials: H
authors.lastname: Linkova
authors.affiliation: From the Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); Department of Cardiology, University Hospital Kralovske Vinohrady, Prague (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); and Department of Cardiology, Central Military Hospital, Prague, Czech Republic (M.M., J.V., M.H.).
authors.forename: Jiri
authors.initials: J
authors.lastname: Vrana
authors.affiliation: From the Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); Department of Cardiology, University Hospital Kralovske Vinohrady, Prague (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); and Department of Cardiology, Central Military Hospital, Prague, Czech Republic (M.M., J.V., M.H.).
authors.forename: Martin
authors.initials: M
authors.lastname: Hajsl
authors.affiliation: From the Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); Department of Cardiology, University Hospital Kralovske Vinohrady, Prague (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); and Department of Cardiology, Central Military Hospital, Prague, Czech Republic (M.M., J.V., M.H.).
authors.forename: Tomas
authors.initials: T
authors.lastname: Budesinsky
authors.affiliation: From the Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); Department of Cardiology, University Hospital Kralovske Vinohrady, Prague (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); and Department of Cardiology, Central Military Hospital, Prague, Czech Republic (M.M., J.V., M.H.).
authors.forename: Libor
authors.initials: L
authors.lastname: Lisa
authors.affiliation: From the Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); Department of Cardiology, University Hospital Kralovske Vinohrady, Prague (P.W., R.P., P.T., H.L., T.B., L.L., V.K.); and Department of Cardiology, Central Military Hospital, Prague, Czech Republic (M.M., J.V., M.H.).
authors.forename: Viktor
authors.initials: V
authors.lastname: Kocka
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000628:therapy*; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies; D054457:Tissue Scaffolds; D014057:Tomography, X-Ray Computed
keywords: bioresorbable scaffold; computed tomography; myocardial infarction; restenosis; stent; stent thrombosis