title: Mean steady-state plasma concentrations of labetalol in patients undergoing antihypertensive therapy.
abstract: 1 Mean steady-state plasma concentrations of labetalol (labetalol Css) in 17 hypertensive patients undergoing chronic treatment with this drug, have been examined in relation to dose, fall in BP, and beta- blockade. 2 A significant relationship (rs = 0.81, P less than 0.001) was observed between labetalol Css and daily dose. 3 No correlation was found between labetalol Css and antihypertensive response. 4 In thirteen patients, there seemed to be significant relationship between labetalol Css and beta-blockade (rs = 0.72, P less than 0.005). In three patients, the degree of beta-blockade was disproportionate to the drug concentration.
authors.forename: G L
authors.initials: GL
authors.lastname: Sanders
authors.forename: P A
authors.initials: PA
authors.lastname: Routledge
authors.forename: A
authors.initials: A
authors.lastname: Ward
authors.forename: D M
authors.initials: DM
authors.lastname: Davies
authors.forename: M D
authors.initials: MD
authors.lastname: Rawlins