title: The Use of Quaternary Ammonium to Combat Dental Caries.
abstract: Resin composites and adhesives are increasingly popular in dental restorations, but secondary caries is one of the main reasons for restoration failure. Quaternary ammonium monomers (QAMs) have an anti-microbial effect and are widely used in many fields. Since the concept of the immobilized antibacterial effect was put forward, dental restorations containing QAMs have been studied to reduce secondary caries. Previous studies have been struggling to develop novel anti-caries materials which might have triple benefits: good mechanical properties, antibacterial effects and remineralization potentials. Different kinds of QAMs have been proven to be effective in inhibiting the growth and metabolism of biofilms. Combination of QAMs and other nanoparticles in resin composites and adhesives could enhance their anti-caries capability. Therefore, QAMs are promising to show significant impact on the future of restorative and preventive dentistry.
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610000, China ; Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610000, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Ge
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610000, China ; Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610000, China.
authors.forename: Suping
authors.initials: S
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610000, China ; Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610000, China.
authors.forename: Xuedong
authors.initials: X
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610000, China ; Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610000, China.
authors.forename: Haohao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Biomaterials & Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA.
authors.forename: Hockin H K
authors.initials: HH
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610000, China ; Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610000, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Cheng
keywords: anti-biofilms; dental caries; dental materials; quaternary ammonium monomer