title: Notch in T Cell Differentiation: All Things Considered.
abstract: Differentiation of naïve T cells into effector cells is required for optimal protection against different classes of microbial pathogen and for the development of immune memory. Recent findings have revealed important roles for the Notch signaling pathway in T cell differentiation into all known effector subsets, raising the question of how this pathway controls such diverse differentiation programs. Studies in preclinical models support the therapeutic potential of manipulating the Notch pathway to alleviate immune pathology, highlighting the importance of understanding the mechanisms through which Notch regulates T cell differentiation and function. We review these findings here, and outline both unifying principles involved in Notch-mediated T cell fate decisions and cell type- and context-specific differences that may present the most suitable points for therapeutic intervention.
authors.affiliation: Department of Hematopoiesis, Sanquin and Landsteiner Laboratory at the CLB, Plesmanlaan125, 1066CX, Amsterdam, the Netherlands. Electronic address: d.amsen@Sanquin.nl.
authors.forename: Derk
authors.initials: D
authors.lastname: Amsen
authors.affiliation: Department of Hematopoiesis, Sanquin and Landsteiner Laboratory at the CLB, Plesmanlaan125, 1066CX, Amsterdam, the Netherlands.
authors.forename: Christina
authors.initials: C
authors.lastname: Helbig
authors.affiliation: Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Backer
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D051880:Receptors, Notch / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D051880:Receptors, Notch