title: Clinical efficacy and safety of laparoscopic nerve-sparing radical hysterectomy for locally advanced cervical cancer.
abstract: OBJECTIVE
  To evaluate the feasibility and safety of laparoscopic nerve-sparing radical hysterectomy (LNRH) for locally advanced cervical cancer (LACC) after neoadjuvant chemotherapy (NACT).
  
  
  METHODS
  120 patients with stage Ib2 and IIa2 cervical cancer were treated with surgery combined with preoperative NACT in the Department of Obstetrics and Gynecology, PLA General Hospital. Eligible patients were divided into two groups according to surgery type: patients who underwent LNRH were assigned to one group, while the second group included patients who underwent laparoscopic radical hysterectomy (LRH) after administration of NACT. We compared these patients' general clinical information and surgical characteristics, and we assessed their bladder function and intestinal function recovery by questionnaire.
  
  
  RESULTS
  No significant differences were found between the groups in patients' age or surgical characteristics. The mean duration of postoperative catheterization in the LNRH group was shorter than in the LRH group (P < 0.001). The intestinal and bladder function of patients in the LNRH group also recovered better than that of patients in the LRH group.
  
  
  CONCLUSIONS
  LNRH is a feasible and safe procedure for LACC after NACT and reduces surgical complications.
authors.affiliation: Department of Obstetrics and Gynecology, PLA General Hospital, Beijing, PR China; Department of Obstetrics, The General Hospital of Jinan Military Command, Jinan, PR China.
authors.forename: Zhongyu
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, PLA General Hospital, Beijing, PR China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, PLA General Hospital, Beijing, PR China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Department of Obstetrics and Gynecology, PLA General Hospital, Beijing, PR China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, PLA General Hospital, Beijing, PR China.
authors.forename: Yizhuo
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynecology, PLA General Hospital, Beijing, PR China. Electronic address: yqyao301hp@163.com.
authors.forename: Yuanqing
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Department of Obstetrics, The General Hospital of Jinan Military Command, Jinan, PR China. Electronic address: ZTY6812@163.com.
authors.forename: Tongyu
authors.initials: T
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000367:Age Factors; D001341:Autonomic Nervous System; D016063:Blood Loss, Surgical / Q000706:statistics & numerical data; D002277:Carcinoma / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D007422:Intestines; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods*; D007902:Length of Stay; D008875:Middle Aged; D061646:Operative Time; D059351:Organ Sparing Treatments / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control; D020127:Recovery of Function; D001743:Urinary Bladder; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*
keywords: Laparoscopic; Locally advanced cervical cancer; Neoadjuvant chemotherapy; Nerve-sparing; Radical hysterectomy