title: Volumizing Hyaluronic Acid Filler for Midface Volume Deficit: Results After Repeat Treatment.
abstract: BACKGROUND
  Juvéderm Voluma XC (VYC-20L; hyaluronic acid gel) is approved in the United States for correction of age-related midface volume deficit (MVD).
  
  
  OBJECTIVE
  Assess safety and effectiveness of VYC-20L after repeat treatment.
  
  
  METHODS
  Subjects with MVD underwent optional repeat treatment 12 to 24 months after initial treatment if correction was lost or at 24 months regardless of loss of correction (n = 167). Investigators rated outcomes on the Mid-Face Volume Deficit Scale (MFVDS) and the Global Aesthetic Improvement Scale (GAIS). Subject-rated outcomes were the GAIS, overall satisfaction with facial appearance, achievement of treatment goal, and Self-Perception of Age questionnaire. Subjects recorded treatment-site responses in 30-day diaries.
  
  
  RESULTS
  Mean injection volume for repeat treatment (3.13 mL) was approximately half the mean total injection volume for initial/touch-up treatment (6.8 mL). After repeat treatment, effectiveness was demonstrated on all investigator-rated and subject-rated measures, consistent with results observed after initial treatment. The percentage of subjects improving by ≥1 point on the MFVDS was 82.8% and 91.1% at 6 and 12 months after repeat treatment, respectively. The incidence, severity, and duration of common treatment-site responses were lower after repeat versus initial treatment.
  
  
  CONCLUSIONS
  Repeat treatment with VYC-20L was well tolerated and resulted in high levels of effectiveness and subject satisfaction.
authors.affiliation: *Baumann Cosmetic and Research Institute, Miami, Florida; †Dermatology Surgery and Laser Center, New York, New York; ‡Beer Cosmetic, Surgical and General Dermatology, West Palm Beach and Jupiter, Florida; §The Westmount Institute of Plastic Surgery, Montreal, QC, Canada; ‖Cosmetic Laser Dermatology, San Diego, California; ¶Clinical Professor of Surgery, Division of Plastic Surgery, University of Chicago Pritzker School of Medicine, The Few Institute for Aesthetic Plastic Surgery, Chicago, Illinois; #Suffield, Connecticut; **Allergan plc, Irvine, California.
authors.forename: Leslie
authors.initials: L
authors.lastname: Baumann
authors.forename: Rhoda S
authors.initials: RS
authors.lastname: Narins
authors.forename: Kenneth
authors.initials: K
authors.lastname: Beer
authors.forename: Arthur
authors.initials: A
authors.lastname: Swift
authors.forename: Kimberly J
authors.initials: KJ
authors.lastname: Butterwick
authors.forename: Julius
authors.initials: J
authors.lastname: Few
authors.forename: Adrienne
authors.initials: A
authors.lastname: Drinkwater
authors.forename: Diane K
authors.initials: DK
authors.lastname: Murphy
mesh_terms: D000328:Adult; D000368:Aged; D005145:Face; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007267:Injections; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D012060:Rejuvenation; D016037:Single-Blind Method; D011795:Surveys and Questionnaires; D013997:Time Factors; D055675:Viscosupplements / Q000008:administration & dosage
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid