title: Radiofrequency ablation versus magnetic resonance guided focused ultrasound surgery for minimally invasive treatment of osteoid osteoma: a propensity score matching study.
abstract: OBJECTIVE
  To compare outcomes in pain relief and motor functional recovery in patients with an osteoid osteoma treated by magnetic resonance guided focused ultrasound surgery (MRgFUS) or radiofrequency ablation (RFA) using a propensity score matching study design.
  
  
  METHODS
  Thirty patients with osteoid osteomas were included in this institutional review board (IRB)-approved study. MRgFUS was performed in 15 subjects. These subjects were matched by propensity analysis with a group of 15 subjects treated by RFA. Pain relief in terms of complete response (CR) and motor functional recovery were measured.
  
  
  RESULTS
  A similar proportion of subjects treated by MRgFUS (94 %) or RFA (100 %) experienced CR 12 weeks after treatment, with no significant difference. The improvement in pain control following MRgFUS or RFA paralleled with improved motor functional recovery. The treatment failure rate was 6.6 % in the MRgFUS group and 0 % in the RFA group. No major complications were observed following either ablative treatment.
  
  
  CONCLUSIONS
  Although this study involved a limited number of patients, MRgFUS favourably improves perceived pain and motor functional recovery, with no major complications. No difference was found in the achievement of primary and secondary outcome measures with respect to RFA.
  
  
  CONCLUSIONS
  • To demonstrate the effectiveness of a recent technique for treating osteoid osteoma • MRgFUS results compared with results of the gold standard treatment (RFA) • MRgFUS is effective both from a clinical and functional point of view • No significant side effects compared with RFA.
authors.affiliation: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, via Vetoio, Coppito, 67010, L'Aquila, AQ, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Masciocchi
authors.affiliation: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, via Vetoio, Coppito, 67010, L'Aquila, AQ, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Zugaro
authors.affiliation: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, via Vetoio, Coppito, 67010, L'Aquila, AQ, Italy. arrigoni.francesco@gmail.com.
authors.forename: Francesco
authors.initials: F
authors.lastname: Arrigoni
authors.affiliation: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, via Vetoio, Coppito, 67010, L'Aquila, AQ, Italy.
authors.forename: Giovanni Luca
authors.initials: GL
authors.lastname: Gravina
authors.affiliation: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, via Vetoio, Coppito, 67010, L'Aquila, AQ, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Mariani
authors.affiliation: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, via Vetoio, Coppito, 67010, L'Aquila, AQ, Italy.
authors.forename: Alice
authors.initials: A
authors.lastname: La Marra
authors.affiliation: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, via Vetoio, Coppito, 67010, L'Aquila, AQ, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Zoccali
authors.affiliation: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, via Vetoio, Coppito, 67010, L'Aquila, AQ, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Flamini
authors.affiliation: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, via Vetoio, Coppito, 67010, L'Aquila, AQ, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Barile
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D016015:Logistic Models; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*; D008297:Male; D010017:Osteoma, Osteoid / Q000601:surgery*; D010147:Pain Measurement; D057216:Propensity Score; D020127:Recovery of Function; D017211:Treatment Failure; D055815:Young Adult
keywords: HIFU; MRgFUS; Osteoid osteoma; RFA; Thermal ablation