title: Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis.
abstract: The diagnostic value of SHOX2 DNA methylation in patients with lung cancer remains controversial. Thus, we performed a systematic review and meta-analysis to assess diagnostic accuracy of SHOX2 DNA methylation in the lymph node, bronchial aspirates, pleural effusion, plasma, and tumor tissue for lung cancer. We conducted a comprehensive literature search in PubMed, Ovid, the Cochrane library, and Web of Science databases in May 2015. The diagnostic sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve were pooled using STATA 12.0 software. A total of 2,296 subjects included 1,129 lung cancer patients in eight studies were recruited in this meta-analysis. The summary estimates for SHOX2 DNA methylation in the diagnosis of lung cancer in these studies were pooled SEN =0.70 (95% confidence interval [CI]: 0.46-0.87), SPE =0.96 (95% CI: 0.91-0.99), PLR 20.01 (95% CI: 6.96-57.52), NLR 0.31 (95% CI: 0.15-0.64), and DOR 65.11 (95% CI: 13.10-323.61), and the area under the curve (AUC) was 0.96 (95% CI: 0.94-0.97). SHOX2 DNA methylation has greater diagnostic value in detecting lung cancer. In addition, considering the potential publication bias and high heterogeneity, further research studies with more well-designed and large sample sizes are needed in the future.
authors.affiliation: Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
authors.forename: Qing-Tao
authors.initials: QT
authors.lastname: Zhao
authors.affiliation: Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Guo
authors.affiliation: Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
authors.forename: Hui-En
authors.initials: HE
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
authors.forename: Xiao-Peng
authors.initials: XP
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
authors.forename: Zhi-Kang
authors.initials: ZK
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: Department of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
authors.forename: Guo-Chen
authors.initials: GC
authors.lastname: Duan
keywords: SHOX2; diagnostic test; lung cancer; meta-analysis