title: The association between the CC chemokine ligand 5 -28C>G gene polymorphism and tuberculosis susceptibility.
abstract: OBJECTIVE
  To assess the association between chemotactic chemokine (C-C motif) ligand 5 (CCL5) -28C&gt;G polymorphism and tuberculosis (TB) risk.
  
  
  METHODS
  PubMed, Web of Science, and WanFang were searched up to April 2015 for eligible studies on CCL5 -28C&gt;G  polymorphism. Data was extracted, and pooled odd ratios (ORs) as well as 95% confidence intervals (95% CI) were calculated.
  
  
  RESULTS
  Eight case-control studies were extracted from 8 articles on the polymorphism involving 1852 TB cases and 2068 controls. The results of meta-analysis showed that significant reduced risks were found for the polymorphism with the risk of TB in Asians and Arabs as follows: OR=0.12, 95% CI=0.06-0.26, p=0.000 for mutant  homozygous (GG) versus wild-type homozygous (CC) for Asian descent, OR=0.14, 95% CI=0.07-0.28, p=0.000 for GG versus CC in the Arab descent.
  
  
  CONCLUSIONS
  Our findings demonstrated that CCL5 gene -28C&gt;G   polymorphism might be a protective factor for the development of TB.
authors.affiliation: Institute of Respiratory Diseases,Three Gorges University, Yichang, China. E-mail. 296280621@qq.com.
authors.forename: Hongfang
authors.initials: H
authors.lastname: Lu
authors.forename: Jingang
authors.initials: J
authors.lastname: Wang
authors.forename: Baoan
authors.initials: B
authors.lastname: Gao
authors.forename: Shixiong
authors.initials: S
authors.lastname: Chen
authors.forename: Guangming
authors.initials: G
authors.lastname: Xiang
authors.forename: Shaojuan
authors.initials: S
authors.lastname: Yang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gong
authors.forename: Li
authors.initials: L
authors.lastname: Guan
mesh_terms: D018946:Chemokine CCL5 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D014376:Tuberculosis / Q000235:genetics*
chemical_list: D018946:Chemokine CCL5