title: Potential of neuropeptide Y for preventing or treating post-traumatic stress disorder.
abstract: There is extensive evidence that NPY in the brain can modulate the responses to stress and play a critical role in resistance to, or recovery from, harmful effects of stress. Development of PTSD and comorbid depression following exposure to traumatic stress are associated with low NPY. This review discusses putative mechanisms for NPY's anti-stress actions. Recent preclinical data indicating potential for intranasal delivery of NPY to brain as a promising non-invasive strategy to prevent a variety of neuroendocrine, molecular and behavioral impairments in PTSD model are summarized.
authors.affiliation: Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, United States. Electronic address: sabban@nymc.edu.
authors.forename: Esther L
authors.initials: EL
authors.lastname: Sabban
authors.affiliation: Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, United States.
authors.forename: Lishay G
authors.initials: LG
authors.lastname: Alaluf
authors.affiliation: Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, United States.
authors.forename: Lidia I
authors.initials: LI
authors.lastname: Serova
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000378:metabolism*; D013313:Stress Disorders, Post-Traumatic / Q000378:metabolism* / Q000517:prevention & control*
chemical_list: D009478:Neuropeptide Y
keywords: Depression; Intranasal; PTSD; Resilience; Single prolonged stress