title: Improvements in the management of neutropenic sepsis: lessons learned from a district general hospital.
abstract: Neutropenic sepsis is a life-threatening condition with mortality rates reported to range between 2 and 21% in adults. It can occur following chemotherapy treatment, due to disease (such as haematological conditions affecting the bone marrow) and in patients on disease-modifying agents (such as patients receiving methotrexate for rheumatoid arthritis). Appropriate emergency treatment is essential and achieving intravenous antibiotic door-to-needle time of less than 1 hour is a key target. Shortfalls in the management of patients presenting to teams with limited expertise in this area were identified in the National Confidential Enquiry into Patient Outcome and Death report in 2008, leading to recommendations including the need for an acute oncology service (AOS) at all hospitals with either an emergency department or medical admissions unit. Practice at Weston General Hospital has been audited at three time points since 2008 (in 2008, 2011 and 2013-14) during which there have been several service developments relevant to the management of neutropenic sepsis, including the introduction of an AOS in June 2013. The percentage of patients in which intravenous antibiotic 1-hour door-to-needle time was achieved has improved from 14% (2008) to 31% (2011) to 79% (2013-14) and neutropenic sepsis mortality has decreased from 39% (2008) to 14% (2011) to 0% (2013-14).
authors.affiliation: Weston General Hospital, Weston-super-Mare, UK thomas.wells@nhs.net.
authors.forename: Tom
authors.initials: T
authors.lastname: Wells
authors.affiliation: Weston General Hospital, Weston-super-Mare, UK.
authors.forename: Corrine
authors.initials: C
authors.lastname: Thomas
authors.affiliation: Weston General Hospital, Weston-super-Mare, UK.
authors.forename: Dawn
authors.initials: D
authors.lastname: Watt
authors.affiliation: Weston General Hospital, Weston-super-Mare, UK.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Fountain
authors.affiliation: Weston General Hospital, Weston-super-Mare, UK.
authors.forename: Marjorie
authors.initials: M
authors.lastname: Tomlinson
authors.affiliation: Weston General Hospital, Weston-super-Mare, UK.
authors.forename: Serena
authors.initials: S
authors.lastname: Hilman
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D003695:Delivery of Health Care / Q000592:standards; D006767:Hospitals, District / Q000592:standards / Q000706:statistics & numerical data; D006769:Hospitals, General / Q000592:standards / Q000706:statistics & numerical data; D006801:Humans; D008485:Medical Audit; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy* / Q000401:mortality; D012189:Retrospective Studies; D018805:Sepsis / Q000188:drug therapy* / Q000401:mortality; D061665:Time-to-Treatment / Q000592:standards / Q000706:statistics & numerical data
chemical_list: D000900:Anti-Bacterial Agents
keywords: Neutropenic; antibiotics; door-to-needle time; sepsis