title: Comparative evaluation of oral gabapentin versus clonidine as premedication on preoperative sedation and laryngoscopic stress response attenuation for the patients undergoing general anesthesia.
abstract: BACKGROUND
  Laryngoscopy and endotracheal intubation (L and I) is associated with rise in blood pressure (BP), heart rate (HR), leading to adverse cardiological outcome especially in susceptible individuals. To compare the BP, HR during L and I as well as to evaluate the preoperative sedation status between oral clonidine (Group C) and oral gabapentine (Group G) as premedication for the patients undergoing major surgery under general anesthesia (GA).
  
  
  METHODS
  From April 2008 to December 2009; in a prospective, double-blinded, and randomized controlled study; 100 adult patients of either sex, aged 20-45, of American Society of Anesthesiologists status I and II scheduled to undergo major surgery of >1 hour duration, randomly allocated into groups C and G were pre treated with oral clonidine (200 µg) and gabapentin (800 mg) respectively 2 h prior to induction. Preoperative sedation was assessed 2 h after premedication administration. Hemodynamic parameters were noted just before induction, during L and I 1,3,5,7, and10 min after intubation. The results obtained were then analyzed with statistical unpaired "t" test and Chi-square test and compared.
  
  
  RESULTS
  Preoperative sedation between two groups were similar but group C attenuated HR, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP) more significantly before induction, during L and I, 1, 3, and 5 min, following L and I, while comparing with group G. Again gabapentin-reduced HR, BP, (SBP, DBP, MBP) significantly more at 7 and 10 min after L and I on comparison clonidine.
  
  
  CONCLUSIONS
  Oral clonidine is equally effective in producing preoperative sedation in comparison to oral gabapentin, while on the contrary oral clonidine is more efficacious in reducing laryngoscopic stress response than oral gabapentin.
authors.affiliation: Department of Anaesthesiology, Nil Ratan Sarkar Medical College, Kolkata, West Bengal, India.
authors.forename: Saikat
authors.initials: S
authors.lastname: Majumdar
authors.affiliation: Department of Anaesthesiology, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India.
authors.forename: Anjan
authors.initials: A
authors.lastname: Das
authors.affiliation: Department of Anaesthesiology, Nil Ratan Sarkar Medical College, Kolkata, West Bengal, India.
authors.forename: Haripada
authors.initials: H
authors.lastname: Das
authors.affiliation: Department of Gynecology and Obstetrics, Institute of Post-Graduate Medical Education and Research, Kolkata, West Bengal, India.
authors.forename: Sambhunath
authors.initials: S
authors.lastname: Bandyopadhyay
authors.affiliation: Department of Anaesthesiology, Nil Ratan Sarkar Medical College, Kolkata, West Bengal, India.
authors.forename: Bimal Kumar
authors.initials: BK
authors.lastname: Hajra
authors.affiliation: Department of Anaesthesiology, Nil Ratan Sarkar Medical College, Kolkata, West Bengal, India.
authors.forename: Dipankar
authors.initials: D
authors.lastname: Mukherjee
keywords: Clonidine; gabapentin; general anaesthesia; laryngoscopy and endotracheal intubation; sedation