title: Metabolic Serum Profiles for Patients Receiving Allogeneic Stem Cell Transplantation: The Pretransplant Profile Differs for Patients with and without Posttransplant Capillary Leak Syndrome.
abstract: Allogeneic stem cell transplantation is commonly used in the treatment of younger patients with severe hematological diseases, and endothelial cells seem to be important for the development of several posttransplant complications. Capillary leak syndrome is a common early posttransplant complication where endothelial cell dysfunction probably contributes to the pathogenesis. In the present study we investigated whether the pretreatment serum metabolic profile reflects a risk of posttransplant capillary leak syndrome. We investigated the pretransplant serum levels of 766 metabolites for 80 consecutive allotransplant recipients. Patients with later capillary leak syndrome showed increased pretherapy levels of metabolites associated with endothelial dysfunction (homocitrulline, adenosine) altered renal regulation of fluid and/or electrolyte balance (betaine, methoxytyramine, and taurine) and altered vascular function (cytidine, adenosine, and methoxytyramine). Additional bioinformatical analyses showed that capillary leak syndrome was also associated with altered purine/pyrimidine metabolism (i.e., metabolites involved in vascular regulation and endothelial functions), aminoglycosylation (possibly important for endothelial cell functions), and eicosanoid metabolism (also involved in vascular regulation). Our observations are consistent with the hypothesis that the pretransplant metabolic status can be a marker for posttransplant abnormal fluid and/or electrolyte balance.
authors.affiliation: Section Hematology, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway ; Section Hematology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway.
authors.forename: Håkon
authors.initials: H
authors.lastname: Reikvam
authors.affiliation: Section Hematology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway.
authors.forename: Ida-Sofie
authors.initials: IS
authors.lastname: Grønningsæter
authors.affiliation: Section Hematology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway.
authors.forename: Aymen Bushra
authors.initials: AB
authors.lastname: Ahmed
authors.affiliation: Section Hematology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway.
authors.forename: Kimberley
authors.initials: K
authors.lastname: Hatfield
authors.affiliation: Section Hematology, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway ; Section Hematology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway.
authors.forename: Øystein
authors.initials: Ø
authors.lastname: Bruserud
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D019559:Capillary Leak Syndrome / Q000097:blood* / Q000209:etiology; D015777:Eicosanoids / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011687:Purines / Q000378:metabolism; D011743:Pyrimidines / Q000378:metabolism; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous / Q000009:adverse effects; D014882:Water-Electrolyte Balance
chemical_list: D015415:Biomarkers; D015777:Eicosanoids; D011687:Purines; D011743:Pyrimidines