title: Comparing the effect of intravenous dexamethasone, intravenous ondansetron, and their combination on nausea and vomiting in cesarean section with spinal anesthesia.
abstract: BACKGROUND
  Nausea and vomiting are frequently seen in patients undergoing cesarean section (CS) under regional anesthesia. We aimed to compare the antiemetic efficacy of ondansetron and dexamethasone combination with that of the use of each agent alone to decrease the incidence of postdelivery intra- and post-operative nausea and vomiting during CS under spinal anesthesia.
  
  
  METHODS
  A randomized, prospective, double-blind study was performed on 90 patients undergoing planned CS under spinal anesthesia. The patients received 4 mg ondansetron in Group O, 8 mg dexamethasone in Group D, and 4 mg ondansetron +8 mg dexamethasone in Group OD intravenously within 1-2 min after the umbilical cord was clamped. Frequency of postdelivery intra- and post-operative nausea and vomiting episodes was recorded.
  
  
  RESULTS
  A total of 90 eligible patients were included in the study. There were 30 patients in Group O, 30 patients in Group D, and 30 patients in Group OD. Intraoperative nausea in Group D was more than the other two groups. Postoperative nausea in group OD was lesser than the other two groups. Intraoperative vomiting in Group OD was lesser than the other two groups. There was no statistically significant difference among the groups in postoperative vomiting (P > 0.05).
  
  
  CONCLUSIONS
  Combined use of dexamethasone and ondansetron for the same indication seems to increase the antiemetic efficacy.
authors.affiliation: Department of Anesthesiology, Imam Khomeini Hospital, Urmia, Iran.
authors.forename: Shahryar
authors.initials: S
authors.lastname: Sane
authors.affiliation: Department of Anesthesiology, Imam Khomeini Hospital, Urmia, Iran.
authors.forename: Mohammadamin Valizadeh
authors.initials: MV
authors.lastname: Hasanlui
authors.affiliation: Department of Anesthesiology, Imam Khomeini Hospital, Urmia, Iran.
authors.forename: Rahman
authors.initials: R
authors.lastname: Abbasivash
authors.affiliation: Department of Anesthesiology, Imam Khomeini Hospital, Urmia, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Mahoori
authors.affiliation: Department of Anesthesia, Medical School, St-Alzahra Medical Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Seyed Taghi
authors.initials: ST
authors.lastname: Hashemi
authors.affiliation: School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Fahime
authors.initials: F
authors.lastname: Rafiei
keywords: 5-hydroxytryptamine 3 antagonists; dexamethasone; intraoperative; nausea and vomiting; ondansetron; postoperative