title: Cardiac contractility modulation signals improve exercise intolerance and maladaptive regulation of cardiac key proteins for systolic and diastolic function in HFpEF.
authors.affiliation: Charité-University-Medicine Berlin, Campus Rudolf Virchow, Department of Cardiology, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Germany. Electronic address: carsten.tschoepe@charite.de.
authors.forename: Carsten
authors.initials: C
authors.lastname: Tschöpe
authors.affiliation: Charité-University-Medicine Berlin, Campus Rudolf Virchow, Department of Cardiology, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Germany.
authors.forename: Sophie
authors.initials: S
authors.lastname: Van Linthout
authors.affiliation: Charité-University-Medicine Berlin, Campus Rudolf Virchow, Department of Cardiology, Berlin, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Spillmann
authors.affiliation: Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Klein
authors.affiliation: Charité-University-Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology, Berlin, German.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Biewener
authors.affiliation: Heart and Vascular Center (HGZ), Bad Bevensen, Germany.
authors.forename: Andrew
authors.initials: A
authors.lastname: Remppis
authors.affiliation: Medical College of Wisconsin, Milwaukee, USA.
authors.forename: David
authors.initials: D
authors.lastname: Gutterman
authors.affiliation: Department of Cardiovascular Physiology, Institute of Physiology, Ruhr University Bochum, Bochum, Germany.
authors.forename: Wolfgang A
authors.initials: WA
authors.lastname: Linke
authors.affiliation: Charité-University-Medicine Berlin, Campus Rudolf Virchow, Department of Cardiology, Berlin, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Germany; Department of Cardiology, Deutsches Herzzentrum Berlin (DHZB), Berlin, Germany.
authors.forename: Burkert
authors.initials: B
authors.lastname: Pieske
authors.affiliation: Department of Cardiovascular Physiology, Institute of Physiology, Ruhr University Bochum, Bochum, Germany.
authors.forename: Nazha
authors.initials: N
authors.lastname: Hamdani
authors.affiliation: Charité-University-Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology, Berlin, German.
authors.forename: Mattias
authors.initials: M
authors.lastname: Roser
mesh_terms: D002118:Calcium / Q000378:metabolism; D064211:Connectin / Q000378:metabolism; D004558:Electric Stimulation; D005080:Exercise Test; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006333:Heart Failure / Q000378:metabolism* / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism; D011446:Prospective Studies; D040901:Proteomics / Q000379:methods; D011788:Quality of Life; D013318:Stroke Volume / Q000502:physiology; D020257:Ventricular Remodeling / Q000502:physiology
chemical_list: D064211:Connectin; D002118:Calcium
keywords: Ca(2+) modulation; Cardiac contractility modulation; HFpEF; Proteomics; Reverse remodeling; Titin