title: Update on Survival in Osteosarcoma.
abstract: Osteosarcoma is the most common primary bone malignancy in children. Treatment has evolved to include systemic chemotherapy and local control surgery. Although survival improved initially in a drastic fashion with this approach, recent decades have seen little to no further gains in this area. Limb salvage surgery evolved with effective chemotherapy and advances in imaging, and continues to improve in the recent era. This article serves as a review of survival in high-grade osteosarcoma: prognostic factors, advances in chemotherapy and surgery, late effects of chemotherapy and surgery in survivors, and future directions.
authors.affiliation: Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA; Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA. Electronic address: manders6@bidmc.harvard.edu.
authors.forename: Megan E
authors.initials: ME
authors.lastname: Anderson
mesh_terms: D001859:Bone Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000556:secondary / Q000601:surgery; D006801:Humans; D023821:Limb Salvage; D009364:Neoplasm Recurrence, Local; D012516:Osteosarcoma / Q000188:drug therapy / Q000401:mortality* / Q000556:secondary / Q000601:surgery; D011379:Prognosis; D019651:Plastic Surgery Procedures; D016019:Survival Analysis
keywords: Late effects; Limb salvage surgery; Osteosarcoma; Prognosis; Survival; Systemic chemotherapy