title: Proteus endocarditis in an intravenous drug user.
abstract: Infective endocarditis (IE) is a life-threatening condition with adverse consequences and increased mortality, despite improvements in treatment options. Diagnosed patients usually require a prolonged course of antibiotics, with up to 40-50% requiring surgery during initial hospital admission. We report a case of a 42-year-old intravenous drug user who presented feeling generally unwell, with lethargy, rigours, confusion and a painful swollen right leg. He was subsequently diagnosed with Proteus mirabilis endocarditis (fulfilling modified Duke criteria for possible IE) and deep vein thrombosis (DVT). He was successfully treated with single antibiotic therapy without needing surgical intervention or requiring anticoagulation for his DVT. Proteus endocarditis is extremely uncommon, with a limited number of case reports available in the literature. This case illustrates how blood cultures are invaluable in the diagnosis of IE, especially that due to unusual microorganisms. Our case also highlights how single antibiotic therapy can be effective in treating Proteus endocarditis.
authors.affiliation: Cardiff University, Cardiff, UK Ysbyty Gwynedd, Bangor, UK.
authors.forename: Rohan
authors.initials: R
authors.lastname: Goel
authors.affiliation: Ysbyty Gwynedd, Bangor, UK.
authors.forename: Baskar
authors.initials: B
authors.lastname: Sekar
authors.affiliation: Ysbyty Gwynedd, Bangor, UK.
authors.forename: Mark N
authors.initials: MN
authors.lastname: Payne
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004697:Endocarditis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis / Q000382:microbiology; D006801:Humans; D008297:Male; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000188:drug therapy; D011512:Proteus Infections / Q000175:diagnosis* / Q000188:drug therapy; D011513:Proteus mirabilis; D015819:Substance Abuse, Intravenous / Q000150:complications*; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000175:diagnosis
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin