title: [Molecular, preclinical, and clinical comparative data regarding different strains of bacillus Calmette-Guérin (BCG): Review by the French Urological Association Oncology Committee (CCAFU)].
abstract: OBJECTIVE
  To review the differences between the BCG strains used for the treatment of non-muscle invasive bladder cancer (NMIBC) at the molecular level, regarding cytotoxicity, immunogenicity, clinical efficiency, and safety.
  
  
  METHODS
  A systematic review of the literature search was performed from the database MedLine, focused on the following keywords: BCG; bladder; strain; genome; cytotoxicity; immune response; efficiency; safety.
  
  
  RESULTS
  Genetic differences between BCG strains have been identified and correlated to their time to differentiation from their initial cultures start, assuming a lower resistance to the host immune defenses of Tice and Danish strains compared to the Connaught strain. Preclinical comparative data showed superior cytotoxic effect and immunogenicity of the Connaught strain compared to Tice and Danish strains. The phase III trials have shown superior efficiency of BCG Connaught compared to BCG Tice and BCG Danish compared to BCG Tice regarding recurrence-free survival.
  
  
  CONCLUSIONS
  Among BCG strains used in France in NMIBC treatment, preclinical and clinical efficiency of Connaught strain was higher than that of the Tice strain. The limits of the currently available studies lie primarily in the lack of use of maintenance therapy.
authors.affiliation: Service d'urologie, hôpital Foch, université Versailles - Saint-Quentin-en-Yvelines, 40, rue Worth, 92150 Suresnes, France. Electronic address: y.neuzillet@hopital-foch.org.
authors.forename: Y
authors.initials: Y
authors.lastname: Neuzillet
authors.affiliation: Service d'urologie, clinique de Meudon, 92360 Meudon, France; Clinique de l'Alma, 75007 Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Dubosq
authors.affiliation: Service d'urologie, hôpital Cochin, université Paris Descartes, 75679 Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Xylinas
authors.affiliation: Service d'urologie, hôpital privé de la Louvière, générale de santé, 59000 Lille, France.
authors.forename: P
authors.initials: P
authors.lastname: Colin
authors.affiliation: Service d'anatomopathologie, groupe hospitalier de la Pitié-Salpêtrière, université Pierre-et-Marie-Curie, 75013 Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Comperat
authors.affiliation: Service d'oncologie médicale, CHU de Nîmes, 30000 Nîmes, France.
authors.forename: N
authors.initials: N
authors.lastname: Houede
authors.affiliation: Service d'urologie, CHU de Reims, 51000 Reims, France.
authors.forename: S
authors.initials: S
authors.lastname: Larre
authors.affiliation: Service d'urologie, hôpital Henri-Mondor, université Paris-Est, 94010 Créteil, France.
authors.forename: A
authors.initials: A
authors.lastname: Masson-Lecomte
authors.affiliation: Service d'urologie, hôpital Bicêtre, université Paris-Sud, 94270 Le Kremlin-Bicêtre, France.
authors.forename: G
authors.initials: G
authors.lastname: Pignot
authors.affiliation: Service de radiologie, CHRU de Lille, 59037 Lille, France.
authors.forename: P
authors.initials: P
authors.lastname: Puech
authors.affiliation: Service d'urologie, CHU Rangueil, 31400 Toulouse, France.
authors.forename: M
authors.initials: M
authors.lastname: Roumiguie
authors.affiliation: Service d'urologie, hôpital européen Georges-Pompidou, université Paris Descartes, 75015 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Mejean
authors.affiliation: Service d'urologie, groupe hospitalier de la Pitié-Salpêtrière, université Pierre-et-Marie-Curie, 75013 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Roupret
mesh_terms: D006801:Humans; D009163:Mycobacterium bovis / Q000145:classification* / Q000235:genetics / Q000276:immunology
keywords: BCG; Bladder; Cytotoxicity; Cytotoxicité; Efficacité; Efficiency; Genome; Génome; Immune response; Réaction immunitaire; Safety; Souche; Strain; Tolérance; Vessie