title: PEGylated hyperbranched polyphosphoester based nanocarriers for redox-responsive delivery of doxorubicin.
abstract: Redox-responsive polymers exhibit great potential as drug delivery systems. Herein, a redox-responsive PEGylated hyperbranched polyphosphoester (PPE) was synthesized through (A2 + B3) type polycondensation. The obtained hyperbranched PPE can self-assemble into nanoparticles in water. The biocompatibility of the nanoparticles was evaluated. The hydrophobic chemotherapy drug doxorubicin (DOX) can be efficiently encapsulated into the obtained nanoparticles. Such DOX-loaded nanoparticles exhibited excellent stability due to the PEGylation, and showed redox-responsive drug release behavior. In addition, flow cytometric analyses demonstrated that the redox-responsive nanoparticles could be efficiently internalized into the human breast cancer cell line MDA-MB-231, and intracellular glutathione enhanced the intracellular drug release from the redox-responsive hyperbranched PPE based nanoparticles. Therefore, such nanoparticles resulted in the enhanced inhibition of tumor cell growth, suggesting the potential of redox-responsive PEGylated hyperbranched PPE in anticancer drug delivery.
authors.affiliation: School of Medical Engineering, Hefei University of Technology, Hefei, Anhui 230027, People's Republic of China. yangxz@hfut.edu.cn.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.affiliation: School of Medical Engineering, Hefei University of Technology, Hefei, Anhui 230027, People's Republic of China. yangxz@hfut.edu.cn.
authors.forename: Pan
authors.initials: P
authors.lastname: Zheng
authors.affiliation: School of Medical Engineering, Hefei University of Technology, Hefei, Anhui 230027, People's Republic of China. yangxz@hfut.edu.cn.
authors.forename: Ziyang
authors.initials: Z
authors.lastname: Cao
authors.affiliation: School of Medical Engineering, Hefei University of Technology, Hefei, Anhui 230027, People's Republic of China. yangxz@hfut.edu.cn.
authors.forename: Yinchu
authors.initials: Y
authors.lastname: Ma
authors.affiliation: School of Medical Engineering, Hefei University of Technology, Hefei, Anhui 230027, People's Republic of China. yangxz@hfut.edu.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Medical Engineering, Hefei University of Technology, Hefei, Anhui 230027, People's Republic of China. yangxz@hfut.edu.cn.
authors.forename: Haisheng
authors.initials: H
authors.lastname: Qian
authors.affiliation: School of Medical Engineering, Hefei University of Technology, Hefei, Anhui 230027, People's Republic of China. yangxz@hfut.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Tao
authors.affiliation: School of Medical Engineering, Hefei University of Technology, Hefei, Anhui 230027, People's Republic of China. yangxz@hfut.edu.cn.
authors.forename: Xianzhu
authors.initials: X
authors.lastname: Yang
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation / Q000187:drug effects*; D005978:Glutathione / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology*; D011108:Polymers / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D011108:Polymers; D011092:Polyethylene Glycols; D004317:Doxorubicin; D005978:Glutathione