title: Nocturnal Oxygen Desaturation Index is Inversely Correlated with Airflow Limitation in Patients with Chronic Obstructive Pulmonary Disease.
abstract: The concurrent diagnosis of chronic obstructive pulmonary disease (COPD) and sleep apnoea-hypopnoea syndrome (SAHS) (overlap syndrome), can contribute to worsening respiratory symptoms, but whether the severity of COPD is associated with co-morbid SAHS is unknown. We investigated whether the severity of COPD is associated with the complication of SAHS by examination of nocturnal oximetry as an alternative to polysomnography. Patients with COPD concurrently completed nocturnal oximetry, pulmonary function tests, a COPD assessment test, an Epworth sleepiness scale and a hospital anxiety and depression scale to evaluate the severity of COPD and possible concurrent presence of SAHS. We retrospectively analysed the data to assess correlation between the oxygen desaturation index (ODI) and each clinical variables and evaluated the predictors of ODI ≥ 15. This study included 103 patients (91 males, 88%) with a mean age of 72 ± 8 years and body mass index of 22 ± 3 kg/m(2). ODI was positively correlated with FEV1, FEV1/FVC and FEV1% predicted, which meant that ODI was inversely correlated with airflow limitation. Univariate logistic regression analysis revealed that FEV1% predicted and FEV1/FVC were predictors of ODI ≥ 15. ODI is inversely correlated with airflow limitation and milder COPD patients may have co-morbid SAHS.
authors.affiliation: a Department of Respiratory Medicine , Shinko Hospital, Kobe , Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Tamai
authors.affiliation: a Department of Respiratory Medicine , Shinko Hospital, Kobe , Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Matsuoka
authors.affiliation: a Department of Respiratory Medicine , Shinko Hospital, Kobe , Japan.
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: a Department of Respiratory Medicine , Shinko Hospital, Kobe , Japan.
authors.forename: Harukazu
authors.initials: H
authors.lastname: Yoshimatsu
authors.affiliation: a Department of Respiratory Medicine , Shinko Hospital, Kobe , Japan.
authors.forename: Daiki
authors.initials: D
authors.lastname: Masuya
authors.affiliation: a Department of Respiratory Medicine , Shinko Hospital, Kobe , Japan.
authors.forename: Nariyasu
authors.initials: N
authors.lastname: Nakashima
authors.affiliation: a Department of Respiratory Medicine , Shinko Hospital, Kobe , Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Okada
authors.affiliation: a Department of Respiratory Medicine , Shinko Hospital, Kobe , Japan.
authors.forename: Nao
authors.initials: N
authors.lastname: Oda
authors.affiliation: a Department of Respiratory Medicine , Shinko Hospital, Kobe , Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Inoue
authors.affiliation: a Department of Respiratory Medicine , Shinko Hospital, Kobe , Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Koma
authors.affiliation: a Department of Respiratory Medicine , Shinko Hospital, Kobe , Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Otsuka
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D010092:Oximetry; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*; D017286:Polysomnography; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D012119:Respiration; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D020181:Sleep Apnea, Obstructive / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D010100:Oxygen
keywords: airflow limitation; chronic obstructive pulmonary disease; oximetry; oxygen desaturation index; sleep apnea–hypopnea syndrome