title: Examination of the Fractalkine and Fractalkine Receptor Expression in Fallopian Adenocarcinoma Reveals Differences When Compared to Ovarian Carcinoma.
abstract: Fallopian adenocarcinoma is a rare malignancy arising in the epithelium of the fallopian tube. Fallopian tube epithelium has been proposed as a tissue origin for high-grade serous ovarian carcinoma, the deadliest gynecologic malignancy. Given the commonalities in dissemination and treatment of these malignancies, we contemplated the possibility of similar patterns of gene expression underlying their progression. To reveal potential similarities or differences in the gene expression of fallopian adenocarcinoma and high-grade serous ovarian carcinoma, we tested expression of the fractalkine receptor (CX3CR1) and its ligand, fractalkine (CX3CL1), in the specimens of normal and pathologic fallopian tube using immunohistochemistry. Our data show that CX3CR1 is expressed in the normal, cancer adjacent normal, inflammatory, and malignant fallopian epithelium. CX3CL1 was expressed only by the normal and cancer adjacent normal fallopian tube epithelium; its expression was largely lost in the inflammatory and malignant fallopian epithelium. In opposite, both CX3CR1 and CX3CL1 are expressed in high-grade serous ovarian carcinoma. These findings are consistent with an idea that fallopian adenocarcinoma and high-grade serous ovarian carcinoma, although currently thought to arise from the same organ, may not share similar molecular characteristics.
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. hgurler@uic.edu.
authors.forename: Hilal
authors.initials: H
authors.lastname: Gurler
authors.affiliation: Department of Pathology, University of Illinois at Chicago, 840 South Wood Street, Chicago, IL 60612, USA. vmacias@uic.edu.
authors.forename: Virgilia
authors.initials: V
authors.lastname: Macias
authors.affiliation: Department of Pathology, University of Illinois at Chicago, 840 South Wood Street, Chicago, IL 60612, USA. aballa@uic.edu.
authors.forename: Andre A
authors.initials: AA
authors.lastname: Kajdacsy-Balla
authors.affiliation: Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. mvb@uic.edu.
authors.forename: Maria V
authors.initials: MV
authors.lastname: Barbolina
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism*; D000073883:CX3C Chemokine Receptor 1; D054428:Chemokine CX3CL1 / Q000235:genetics / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D005185:Fallopian Tube Neoplasms / Q000235:genetics / Q000378:metabolism*; D005187:Fallopian Tubes / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism*; D019707:Receptors, Chemokine / Q000235:genetics / Q000378:metabolism*
chemical_list: D000073883:CX3C Chemokine Receptor 1; C515538:CX3CL1 protein, human; C095235:CX3CR1 protein, human; D054428:Chemokine CX3CL1; D019707:Receptors, Chemokine
keywords: fallopian carcinoma; fractalkine; fractalkine receptor; ovarian carcinoma