title: Rosetta Stone of NLR Innate Immunity.
abstract: The formation of NLR inflammasomes is a central step in the initiation of the innate immune response. Two recent publications describe the structure of the NAIP2-NLRC4 inflammasome and derive an elegant model of NLR inflammasome formation, whereby binding of the pathogen-molecule-bound NLR NAIP2 to NLRC4 leads to the activation of NLRC4 and initiation of self-propagating NLRC4 inflammasome formation.
authors.affiliation: NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Bernhard C
authors.initials: BC
authors.lastname: Lechtenberg
authors.affiliation: NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: sriedl@SBPdiscovery.org.
authors.forename: Stefan J
authors.initials: SJ
authors.lastname: Riedl
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000737:chemistry*; D001426:Bacterial Proteins / Q000737:chemistry*; D002135:Calcium-Binding Proteins / Q000737:chemistry*; D007113:Immunity, Innate; D058847:Inflammasomes / Q000276:immunology*; D051616:Neuronal Apoptosis-Inhibitory Protein / Q000737:chemistry*
chemical_list: D051017:Apoptosis Regulatory Proteins; D001426:Bacterial Proteins; D002135:Calcium-Binding Proteins; D058847:Inflammasomes; D051616:Neuronal Apoptosis-Inhibitory Protein
keywords: cryo-EM; inflammasome; inflammation; innate immunity