title: Zeolite Nanoparticles for Selective Sorption of Plasma Proteins.
abstract: The affinity of zeolite nanoparticles (diameter of 8-12 nm) possessing high surface area and high pore volume towards human plasma proteins has been investigated. The protein composition (corona) of zeolite nanoparticles has been shown to be more dependent on the plasma protein concentrations and the type of zeolites than zeolite nanoparticles concentration. The number of proteins present in the corona of zeolite nanoparticles at 100% plasma (in vivo state) is less than with 10% plasma exposure. This could be due to a competition between the proteins to occupy the corona of the zeolite nanoparticles. Moreover, a high selective adsorption for apolipoprotein C-III (APOC-III) and fibrinogen on the zeolite nanoparticles at high plasma concentration (100%) was observed. While the zeolite nanoparticles exposed to low plasma concentration (10%) exhibited a high selective adsorption for immunoglobulin gamma (i.e. IGHG1, IGHG2 and IGHG4) proteins. The zeolite nanoparticles can potentially be used for selectively capture of APOC-III in order to reduce the activation of lipoprotein lipase inhibition during hypertriglyceridemia treatment. The zeolite nanoparticles can be adapted to hemophilic patients (hemophilia A (F-VIII deficient) and hemophilia B (F-IX deficient)) with a risk of bleeding, and thus might be potentially used in combination with the existing therapy.
authors.affiliation: Faculty of Science, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Rahimi
authors.affiliation: School of Chemical Sciences, University Sains Malaysia, 11800 USM, Malaysia.
authors.forename: E-P
authors.initials: EP
authors.lastname: Ng
authors.affiliation: Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands.|Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.
authors.forename: K
authors.initials: K
authors.lastname: Bakhtiari
authors.affiliation: Institute for Liver and Digestive Health, Division of Medicine, University College London (UCL), London, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Vinciguerra
authors.affiliation: Laboratory of Catalysis and Spectroscopy, ENSICAEN, University of Caen, CNRS, 6 Boulevard du Maréchal Juin, 14050 Caen, France.
authors.forename: H
authors.initials: H
authors.lastname: Ali Ahmad
authors.affiliation: Laboratory of Catalysis and Spectroscopy, ENSICAEN, University of Caen, CNRS, 6 Boulevard du Maréchal Juin, 14050 Caen, France.
authors.forename: H
authors.initials: H
authors.lastname: Awala
authors.affiliation: Laboratory of Catalysis and Spectroscopy, ENSICAEN, University of Caen, CNRS, 6 Boulevard du Maréchal Juin, 14050 Caen, France.
authors.forename: S
authors.initials: S
authors.lastname: Mintova
authors.affiliation: University of Groningen, University Medical Center Groningen, Department Bioengineering, Groningen, the Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Daghighi
authors.affiliation: Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Iran.
authors.forename: F
authors.initials: F
authors.lastname: Bakhshandeh Rostami
authors.affiliation: University of Groningen, University Medical Center Groningen, Department Cell Biology, Department medical proteomics, Groningen, the Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: de Vries
authors.affiliation: Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands.
authors.forename: M M
authors.initials: MM
authors.lastname: Motazacker
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands.
authors.forename: M P
authors.initials: MP
authors.lastname: Peppelenbosch
authors.affiliation: Division of Cardiovascular Medicine, School of Medicine, Stanford University, Stanford, California, USA.|Cardiovascular Institute, School of Medicine, Stanford University, Stanford, California, USA.
authors.forename: M
authors.initials: M
authors.lastname: Mahmoudi
authors.affiliation: University of Groningen, University Medical Center Groningen, Department Cell Biology, Department medical proteomics, Groningen, the Netherlands.|Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Rezaee
mesh_terms: D000327:Adsorption; D053305:Apolipoprotein C-III / Q000737:chemistry; D001777:Blood Coagulation; D001798:Blood Proteins / Q000737:chemistry; D002853:Chromatography, Liquid; D005340:Fibrinogen / Q000737:chemistry; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D009584:Nitrogen / Q000737:chemistry; D000066970:Protein Corona; D053719:Tandem Mass Spectrometry; D017641:Zeolites / Q000737:chemistry
chemical_list: D053305:Apolipoprotein C-III; D001798:Blood Proteins; D000066970:Protein Corona; D017641:Zeolites; D005340:Fibrinogen; D009584:Nitrogen