title: Magnetic Resonance Image Sequence Influences the Relationship between Bone Marrow Lesions Volume and Pain: Data from the Osteoarthritis Initiative.
abstract: Subchondral bone marrow lesions (BMLs) are related to structural and symptomatic osteoarthritis progression. However, it is unclear how sequence selection influences a quantitative BML measurement and its construct validity. We compared quantitative assessment of BMLs on intermediate-weighted fat suppressed (IW FS) turbo spin echo and 3-dimensional dual echo steady state (3D DESS) sequences. We used a customized software to measure 30 knees' (24- and 48-month MR images) BMLs on both sequences. The results showed that the IW FS sequences have much larger BML volumes (median: IW FS = 1840 mm(3); DESS = 191 mm(3)) and BML volume change (between 24 and 48 months) than DESS sequence and demonstrate more BML volume change. The 24-month BML volume on IW FS is correlated with BML volume on DESS (r s = 0.83). BML volume change on IW FS is not significantly correlated with change on DESS. The 24-month WOMAC pain is correlated with the 24-month BMLs on IW FS (r s = 0.39) but not DESS. The change in WOMAC pain is correlated with BML volume change on IW FS (r s = 0.37) but not DESS. Overall, BML quantification on IW FS offers better validity and statistical power than BML quantification on a 3D DESS sequence.
authors.affiliation: Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box No. 406, Boston, MA 02111, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box No. 406, Boston, MA 02111, USA.
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Driban
authors.affiliation: The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts Clinical and Translational Science Institute, Tufts University, 800 Washington Street, Box No. 63, Boston, MA 02111, USA.
authors.forename: Lori Lyn
authors.initials: LL
authors.lastname: Price
authors.affiliation: Medical Care Line and Research Care Line, Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey VAMC, Houston, TX 77030, USA ; Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, 1 Baylor Plaza, BCM-285, Houston, TX 77030, USA.
authors.forename: Grace H
authors.initials: GH
authors.lastname: Lo
authors.affiliation: Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box No. 406, Boston, MA 02111, USA.
authors.forename: Timothy E
authors.initials: TE
authors.lastname: McAlindon
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000473:pathology*; D010146:Pain / Q000473:pathology*