title: Pd(OAc)2-Catalyzed, AgOAc-Promoted Z Selective Directed β-Arylation of Acrylamide Systems and Stereoselective Construction of Z-Cinnamamide Scaffolds.
abstract: A Pd(OAc)2-catalyzed, AgOAc-promoted and bidentate ligand-directed Z selective C-H activation, followed by the β-arylation of the C(sp(2))-H bond of N-(quinolin-8-yl)acrylamide systems with aryl- and heteroaryl iodides, and a contemporary method for the construction of various Z-cinnamamides and β,β-diarylated acrylamides are reported. A plausible reaction mechanism comprising the bidentate ligand-aided, chelation-based C-H functionalization was proposed for the observed Z selective β-arylation of N-(quinolin-8-yl)acrylamide systems.
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali , Manauli P.O., Sector 81, SAS Nagar, Mohali, Knowledge City, Punjab 140306, India.
authors.forename: Ramarao
authors.initials: R
authors.lastname: Parella
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali , Manauli P.O., Sector 81, SAS Nagar, Mohali, Knowledge City, Punjab 140306, India.
authors.forename: Srinivasarao Arulananda
authors.initials: SA
authors.lastname: Babu