title: Angiotensin II type 1 receptor gene A1166C polymorphism and breast cancer susceptibility.
abstract: Numerous studies have evaluated the association between the angiotensin II type-1 receptor (AGTR1) gene A1166C polymorphism and breast cancer risk. However, the specific association is controversial. The aim of the present study was to derive a more precise estimation of the relationship. A comprehensive research was conducted of the PubMed and the Google Scholar databases through February 2015. Data were assessed using STATA version 12.0. Pooled odds ratios with 95%CIs were derived from the fixed-effect or random-effect models. A total of 911 patients with breast cancer and 1284 controls from 5 case-control studies were included in this meta-analysis. The meta-analysis results showed no significant association between the AGTR1 gene A1166C polymorphism and breast cancer risk. Similarly, in the subgroup analysis regarding ethnicity, no associations were observed. Heterogeneity and publication bias were not observed in this meta-analysis. The A1166C polymorphism in the AGTR1 gene may not be a risk factor for breast cancer. Further, large, and well-designed studies are needed to confirm this conclusion.
authors.affiliation: Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: P W
authors.initials: PW
authors.lastname: Lv
authors.affiliation: Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: M Z
authors.initials: MZ
authors.lastname: Zhu
authors.affiliation: Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: J J
authors.initials: JJ
authors.lastname: He
authors.affiliation: Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: G C
authors.initials: GC
authors.lastname: Guo
authors.affiliation: Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Y T
authors.initials: YT
authors.lastname: Gu
authors.affiliation: Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: M L
authors.initials: ML
authors.lastname: Han
mesh_terms: D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008957:Models, Genetic; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D012307:Risk Factors
chemical_list: C544065:AGTR1 protein, human; D044140:Receptor, Angiotensin, Type 1