title: On signaling pathways: hematopoietic stem cell specification from hemogenic endothelium.
abstract: Hematopoietic stem cells (HSCs) are specified and generated during the embryonic development and have remarkable potential to replenish the full set of blood cell lineages. Researchers have long been interested in clarifying the molecular events involved in HSC specification. Many studies have reported the development of methods for generating functional hematopoietic cells from pluripotent stem cells (PSCs-embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)) for decades. However, the generation of HSCs with robust long-term repopulation potential remains a swingeing challenge, of which a major factor contributing to this failure is the difficulty to define the intraembryonic signals related to the specification of HSCs. Since HSCs directly derive from hemogenic endothelium, in this review, we summarize both in vivo and in vitro studies on conserved signaling pathways that control the specification of HSCs from hemogenic endothelial cells.
authors.affiliation: Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Long
authors.affiliation: Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China. huanghe@zju.edu.cn.
authors.forename: He
authors.initials: H
authors.lastname: Huang
mesh_terms: D000818:Animals; D055415:Bone Morphogenetic Protein 4 / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D055018:Hemangioblasts / Q000166:cytology / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D051880:Receptors, Notch / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D060449:Wnt Signaling Pathway / Q000502:physiology
chemical_list: D055415:Bone Morphogenetic Protein 4; D051880:Receptors, Notch
keywords: HSCs; hemogenic endothelium; signaling pathways