title: Study of Commonest Variety of Sinonasal Malignancy and Its Sex Wise Distribution.
abstract: This study was done to find the commonest variety of sinonasal malignancy and its association with sex.This cross-sectional study was conducted in the Department of Otolaryngology - Head & Neck Surgery Department, Dhaka Medical College & Hospital and in the Department of Otolaryngology - Head & Neck Surgery Department, Bangabandhu Sheikh Mujib Medical University between January 2009 and December 2009. A total of 146 cases of sinonasal malignancy were consecutively included in the study. The diagnosis was confirmed by histopathology. The mean age was 47.8 years (range: 22-75 years). Over three-quarters (77%) of the patients were male with male to female ratio being 3:1. Nearly one-third (30.8%) of the patients was farmer and over one-third (36.3%) was illiterate. The right sinonasal region was involved in 48.6% cases, left sinonasal region in 39% and both sinonasal region in 12.4% cases. Histopathological diagnosis of sinonasal malignancy revealed that squamous cell carcinoma accounted for 82.9% of sinonasal malignancies, 9.6% adenocarcinoma and the rest were olfactory neuroblastoma, adenoid cystic carcinoma and mucoepidermoid carcinoma. About 96.6% of the tumours involved nasal cavity, 97.9% maxillary sinuses, 17.8% frontal sinuses, 48.6% ethmoidal sinuses and 13% sphenoid sinuses. Over 80% of patients were smoker. Exposure to wood dust was found in 26% of cases. Lather tanning in 4.8% of cases and welding in 4.1% of cases. T staging shows that nearly half (48.6%) of the patients lesion was T2, 29.5% T3, 19.9% T4 and 2.1% T1. None of the patients exhibited lymph node involvement or distant metastasis. Males tend to develop squamous cell carcinoma significantly more than the females with risk of acquiring squamous cell carcinoma being nearly 3(1.1-7.1) times higher in male than that in female (p=0.022). The study concludes that the most common histopathological variety of sinonasal malignancy is squamous cell carcinoma and males are prone to develop this malignancy more frequently than the females.
authors.affiliation: Dr Masroor Rahman, Research Assistant, Department of Otolaryngology-Head & Neck Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
authors.forename: M
authors.initials: M
authors.lastname: Rahman
authors.forename: M A
authors.initials: MA
authors.lastname: Siddique
authors.forename: M I
authors.initials: MI
authors.lastname: Ali
authors.forename: T
authors.initials: T
authors.lastname: Rahman
authors.forename: A A
authors.initials: AA
authors.lastname: Choudhury
authors.forename: J A
authors.initials: JA
authors.lastname: Khan
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology; D000328:Adult; D000368:Aged; D001459:Bangladesh / Q000453:epidemiology; D018277:Carcinoma, Mucoepidermoid / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000453:epidemiology* / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000453:epidemiology; D017678:Sex Distribution