title: Single Nucleotide Polymorphisms as Genomic Markers for High-Throughput Pharmacogenomic Studies.
abstract: Genetic variations in patients have strong impact on their drug therapies and responses because the variations may contribute to the efficacy and/or produce undesirable side effects for any given drug. The Drug Metabolizing Enzymes and Transporters (DMET) assay is a high-throughput technology by Affymetrix that is able to simultaneously genotype variants in multiple genes involved in absorption, distribution, metabolism, and excretion of drugs for subsequent clinical applications, i.e., the assay allows for a precise genetic map that can guide therapeutic interventions and avoid side effects.
authors.affiliation: Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Lonetti
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Via Massarenti, 9, Bologna, 40138, Italy.
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Fontana
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Via Massarenti, 9, Bologna, 40138, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinelli
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Via Massarenti, 9, Bologna, 40138, Italy. ilaria.iacobucci2@unibo.it.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Iacobucci
mesh_terms: D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005819:Genetic Markers / Q000235:genetics; D021141:Nucleic Acid Amplification Techniques; D010597:Pharmacogenetics / Q000379:methods*; D020641:Polymorphism, Single Nucleotide; D012984:Software; D013194:Staining and Labeling; D013223:Statistics as Topic
chemical_list: D005819:Genetic Markers; D004247:DNA
keywords: Drug metabolizing enzymes and transporters; Single nucleotide polymorphisms