title: [IgG4-Related Retroperitoneal fibrosis].
abstract: OBJECTIVE
  To report two new cases of IgG4-related retroperitoneal fibrosis, a recently described pathology.
  
  
  METHODS
  We analyze two cases diagnosed in our center and performed a literature review.
  
  
  RESULTS
  IgG4 related disease is a recently described entity that includes previously not related pathologies. The clinical manifestations are highly variable and its presentation is usually subacute. The treatment of choice is glucocorticoids. In our first case the outcome was favorable with corticosteroids and azathioprine. However, the second case required surgery on 2 occasions with radical nephrectomy. The diagnosis of the latter was made nine years after the onset of symptoms when the biopsy was reviewed; at that moment immunosuppressive therapy was not started.
  
  
  CONCLUSIONS
  It is very important to know and diagnose this disease because of the good response to treatment that prevents complications.
authors.affiliation: Service of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias, Spain.
authors.forename: Rebeca
authors.initials: R
authors.lastname: Fernández Regueiro
authors.affiliation: Service of Urology, Hospital de Cabueñes, Gijón, Asturias, Spain.
authors.forename: Corina
authors.initials: C
authors.lastname: Pérez García
authors.affiliation: Service of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias, Spain.
authors.forename: Eva María
authors.initials: EM
authors.lastname: Fonseca Aizpuru
authors.affiliation: Service of Pathological Anatomy, Hospital de Cabueñes, Gijón, Asturias, Spain.
authors.forename: Carmen Luz
authors.initials: CL
authors.lastname: Menéndez Fernández
authors.affiliation: Service of Urology, Hospital de Cabueñes, Gijón, Asturias, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Fernández Pello
authors.affiliation: Service of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias, Spain. Chief Service of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias, Spain.
authors.forename: Joaqín
authors.initials: J
authors.lastname: Morís de la Tassa
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D008297:Male; D012185:Retroperitoneal Fibrosis / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy
chemical_list: D007074:Immunoglobulin G