title: Asymmetric Radical-Radical Cross-Coupling through Visible-Light-Activated Iridium Catalysis.
abstract: Combining single electron transfer between a donor substrate and a catalyst-activated acceptor substrate with a stereocontrolled radical-radical recombination enables the visible-light-driven catalytic enantio- and diastereoselective synthesis of 1,2-amino alcohols from trifluoromethyl ketones and tertiary amines. With a chiral iridium complex acting as both a Lewis acid and a photoredox catalyst, enantioselectivities of up to 99% ee were achieved. A quantum yield of <1 supports the proposed catalytic cycle in which at least one photon is needed for each asymmetric C-C bond formation mediated by single electron transfer.
authors.affiliation: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse 4, 35043 Marburg (Germany).
authors.forename: Chuanyong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse 4, 35043 Marburg (Germany).
authors.forename: Jie
authors.initials: J
authors.lastname: Qin
authors.affiliation: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse 4, 35043 Marburg (Germany).
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Shen
authors.affiliation: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse 4, 35043 Marburg (Germany).
authors.forename: Radostan
authors.initials: R
authors.lastname: Riedel
authors.affiliation: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse 4, 35043 Marburg (Germany).
authors.forename: Klaus
authors.initials: K
authors.lastname: Harms
authors.affiliation: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse 4, 35043 Marburg (Germany). meggers@chemie.uni-marburg.de.|College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (P.R. China). meggers@chemie.uni-marburg.de.
authors.forename: Eric
authors.initials: E
authors.lastname: Meggers
keywords: asymmetric catalysis; electron transfer; photoredox catalysis; radicals