title: Cancer Incidence in Patients with Atypical Endometrial Hyperplasia Managed by Primary Hysterectomy or Fertility-sparing Treatment.
abstract: OBJECTIVE
  To compare the risk of developing endometrial carcinoma (EC) in young women with atypical endometrial hyperplasia (AEH) undergoing fertility-sparing management compared to women treated by primary hysterectomy.
  
  
  METHODS
  In this multicentric retrospective study, 111 patients with a diagnosis of AEH by endometrial biopsy were included. EC incidence was compared in two groups: 32 patients treated with fertility-sparing management and 79 older patients treated with primary hysterectomy.
  
  
  RESULTS
  The rates of EC diagnosed by pathology of hysterectomy specimens were comparable between the groups. The probability of developing EC at 12, 24 and 36 months were 14%, 21% and 26%, respectively, in patients managed conservatively, and 29%, 37% and 37%, respectively, in patients treated with primary hysterectomy.
  
  
  CONCLUSIONS
  Fertility-sparing management of AEH does not increase the risk of diagnosing EC from the hysterectomy specimen.
authors.affiliation: Department of Obstetrics and Gynecology, Bichat University Hospital, Paris, France.
authors.forename: Clémentine
authors.initials: C
authors.lastname: Gonthier
authors.affiliation: Department of Obstetrics and Gynecology, Tenon University Hospital, Paris, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Piel
authors.affiliation: Department of Obstetrics and Gynecology, Tenon University Hospital, Paris, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Touboul
authors.affiliation: Department of Pathology, Bichat University Hospital, Paris, France.
authors.forename: Francine
authors.initials: F
authors.lastname: Walker
authors.affiliation: Department of Pathology, Tenon University Hospital, Paris, France.
authors.forename: Annie
authors.initials: A
authors.lastname: Cortez
authors.affiliation: Department of Obstetrics and Gynecology, Bichat University Hospital, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Luton
authors.affiliation: Department of Obstetrics and Gynecology, Tenon University Hospital, Paris, France Research Unit S938, Pierre and Marie Curie University, Paris, France.
authors.forename: Emile
authors.initials: E
authors.lastname: Daraï
authors.affiliation: Department of Obstetrics and Gynecology, Bichat University Hospital, Paris, France.
authors.forename: Martin
authors.initials: M
authors.lastname: Koskas
mesh_terms: D000328:Adult; D018450:Disease Progression; D004714:Endometrial Hyperplasia / Q000175:diagnosis / Q000628:therapy*; D016889:Endometrial Neoplasms / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D015994:Incidence; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: Fertility-sparing management; atypical endometrial hyperplasia; endometrial cancer; progression risk