title: Antimicrobial and antioxidant screening of N¢-substituted sulphonyl and benzoyl derivatives of 4-Pyridine carboxylic acid hydrazide.
abstract: In this research program, the antibacterial, antifungal and antioxidant activities of six N'-substituted sulfonyl and benzoyl derivatives of lead molecule PCH were reported. Out of these compounds, sulphonyl derivatives 2,3 and benzoyl derivative 5 showed moderate to good activity against different strains of gram-positive and gram-negative bacteria including B. cereus, B. subtilis, B. thruingiensis and S. pyogenes, S. fecalis and E. coli ATCC 8739. Moreover, upon antifungal screening, the compound, N¢-[(2,4,6-trimethylbenzene) sulfonyl]pyridine-4-carbohydrazide possessed good antifungal activity against Candida species, a causative agent of systemic fungal infections. Antioxidant study demonstrated more than 50% inhibition in DPPH assay for sulphonyl derivative 2 indicating its potential as antioxidant while the other derivatives expressed low level of radical scavenging property.
authors.affiliation: Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Sabahat
authors.initials: S
authors.lastname: Naeem
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Shamim
authors.initials: S
authors.lastname: Akhtar
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Nadia
authors.initials: N
authors.lastname: Asghar
authors.affiliation: Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan.
authors.forename: Sikander Khan
authors.initials: SK
authors.lastname: Sherwani
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Nousheen
authors.initials: N
authors.lastname: Mushtaq
authors.affiliation: Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan.
authors.forename: Arfa
authors.initials: A
authors.lastname: Kamil
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Shaista
authors.initials: S
authors.lastname: Zafar
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Arif
authors.affiliation: H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Zafar Saeed
authors.initials: ZS
authors.lastname: Saify
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D001713:Biphenyl Compounds / Q000737:chemistry; D002175:Candida / Q000187:drug effects / Q000254:growth & development; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D006834:Hydrazines / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D002264:Carboxylic Acids; D006834:Hydrazines; D010851:Picrates; D011725:Pyridines; C004931:1,1-diphenyl-2-picrylhydrazyl