title: Separation and identification of a novel tadalafil analogue adulterant in a dietary supplement.
abstract: A novel tadalafil analogue found in a dietary supplement by routine drug-adulteration screening was isolated by column chromatography and HPLC. On the basis of extensive 1D- and 2D-nuclear magnetic resonance (NMR), infrared (IR) and mass spectral analyses, the structure of the new compound YJ-02 was established as 6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-(1E,2E)-3-phenylallylidene)amino)pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione. Its common name is N-phenylpropenyltadalafil.
authors.affiliation: a Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei City , Taiwan (ROC).
authors.forename: Yen-Chun
authors.initials: YC
authors.lastname: Huang
authors.affiliation: a Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei City , Taiwan (ROC).
authors.forename: Hui-Chun
authors.initials: HC
authors.lastname: Lee
authors.affiliation: b Division of Chinese Medicinal Chemistry , National Research Institute of Chinese Medicine , Taipei , Taiwan (ROC).
authors.forename: Yun-Lian
authors.initials: YL
authors.lastname: Lin
authors.affiliation: c Department of Applied Chemistry , National Pingtung University , Pingtung City , Taiwan (ROC).
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Li
authors.affiliation: a Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei City , Taiwan (ROC).
authors.forename: Chia-Fen
authors.initials: CF
authors.lastname: Tsai
authors.affiliation: a Division of Research and Analysis , Taiwan Food and Drug Administration , Taipei City , Taiwan (ROC).
authors.forename: Hwei-Fang
authors.initials: HF
authors.lastname: Cheng
mesh_terms: D019587:Dietary Supplements; D005506:Food Contamination / Q000032:analysis*; D015394:Molecular Structure; D000068581:Tadalafil / Q000032:analysis* / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000068581:Tadalafil
keywords: N-phenylpropenyltadalafil; Tadalafil analogue; adulterated food supplements