title: Survey of Her2-neu Expression and its Correlation with Histology of Gastric Carcinoma and Gastroesophageal Junction Adenocarcinoma.
abstract: BACKGROUND
  There is increasing evidence that HER2-neu is an important biomarker in gastric carcinomas (GC) and gastroesophageal junction (GEJ) adenocarcinomas. The aim of this study was to evaluate HER2-neu expression and also some clinicopathological features of these neoplasms.
  
  
  METHODS
  We selected 211 paraffin-embedded blocks, 193 GC and 18 GEJ. Then 4 micron sections were prepared for staining with hematoxylin and eosin and also for IHC (Her2-neu). The Chi-square test was used for significance between expression of HER2-neu and clinicopathological parameters.
  
  
  RESULTS
  In patients with advanced cancer of GC and GEJ, HER2-neu overexpression was more associated with the intestinal cancer subtype.
  
  
  CONCLUSIONS
  This could be a guide to new complementary therapy for affected patients.
authors.affiliation: Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran E-mail : amirifard.n@gmail.com.
authors.forename: Seyed-Hamid
authors.initials: SH
authors.lastname: Madani
authors.forename: Ali
authors.initials: A
authors.lastname: Rahmati
authors.forename: Edris
authors.initials: E
authors.lastname: Sadeghi
authors.forename: Sedighe
authors.initials: S
authors.lastname: Khazaei
authors.forename: Masoud
authors.initials: M
authors.lastname: Sadeghi
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Payandeh
authors.forename: Nasrin
authors.initials: N
authors.lastname: Amirifard
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000628:therapy; D004943:Esophagogastric Junction / Q000473:pathology*; D005260:Female; D005784:Gene Amplification / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007414:Intestinal Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis* / Q000235:genetics; D013274:Stomach Neoplasms / Q000473:pathology* / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human