title: Incidental gastrointestinal 18F-Fluorodeoxyglucose uptake associated with lung cancer.
abstract: BACKGROUND
  F-Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is increasingly used for the initial staging and restaging of lung cancer. Incidental gastrointestinal findings are often observed on (18)F-FDG PET/CT. The objective of this study was to assess incidental 18F-FDG uptake by the gastrointestinal tract (GIT) in patients with lung cancer.
  
  
  METHODS
  Two hundred thirty consecutive 18F-FDG PET/CT examinations performed for lung cancer over a 3-year period were retrospectively reviewed for the presence of incidental FDG uptake in the GIT. The charts of patients with positive FDG uptake were then reviewed and analysed to determine the GIT uptake sites, the standardized uptake value (SUV) max and the final clinical diagnosis.
  
  
  RESULTS
  Fifty-two patients (52/230, 23%) demonstrated incidental FDG uptake in the GIT. Thirty-three patients (63.5%) had diffuse uptake (oesophagus, n = 2, colon, n = 31) and 19 patients (36.5%) had focal uptake (oesophagus, n = 1, small bowel, n = 1, ascending colon, n = 5, descending colon, n = 4, sigmoid, n = 4, rectum, n = 3, and anal margin, n = 1). Twelve of the 52 patients with GIT uptake were further investigated, revealing, a diagnosis of malignancy in 4 patients with focal FDG uptake. No significant differences in mean SUVmax were observed between patients with malignant and benign GIT diseases.
  
  
  CONCLUSIONS
  This study demonstrates a high incidence of FDG uptake in the GIT associated with lung cancer. Focal GIT uptake was frequently associated with malignant disease. These results suggest that further GIT investigations should be performed in patients with focal GIT uptake.
authors.affiliation: Service des Maladies Respiratoires, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq Jay, 51092, Reims, Cedex, France. jvellaboucaud@chu-reims.fr.
authors.forename: Juliette
authors.initials: J
authors.lastname: Vella-Boucaud
authors.affiliation: Service de Médecine Nucléaire, Institut Jean Godinot, Centre de Lutte Contre le Cancer à Reims, Reims, France. D.PAPATHANASSIOU@reims.unicancer.fr.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Papathanassiou
authors.affiliation: Service d'Hépato-Gastro-Entérologie et Cancérologie Digestive, Hôpital Robert Debré, CHU de Reims, Reims, France. obouche@chu-reims.fr.|Unité de Médecine Ambulatoire Cancérologie Hématologie, Hôpital Robert Debré, CHU Reims, Reims, France. obouche@chu-reims.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Bouche
authors.affiliation: Service d'Oncologie Médicale, Institut Jean Godinot, Centre de Lutte Contre le Cancer à Reims, Reims, France. alain.prevost@reims.fnclcc.fr.
authors.forename: Alain
authors.initials: A
authors.lastname: Prevost
authors.affiliation: Service de Médecine Nucléaire, Institut Jean Godinot, Centre de Lutte Contre le Cancer à Reims, Reims, France. tlestra@chu-reims.fr.
authors.forename: Thibault
authors.initials: T
authors.lastname: Lestra
authors.affiliation: Service des Maladies Respiratoires, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq Jay, 51092, Reims, Cedex, France. sdury@chu-reims.fr.
authors.forename: Sandra
authors.initials: S
authors.lastname: Dury
authors.affiliation: Service des Maladies Respiratoires, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq Jay, 51092, Reims, Cedex, France. hvallerand@chu-reims.fr.
authors.forename: Hervé
authors.initials: H
authors.lastname: Vallerand
authors.affiliation: Service des Maladies Respiratoires, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq Jay, 51092, Reims, Cedex, France. jmperotin-collard@chu-reims.fr.
authors.forename: Jeanne-Marie
authors.initials: JM
authors.lastname: Perotin
authors.affiliation: Service des Maladies Respiratoires, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq Jay, 51092, Reims, Cedex, France. claunois@chu-reims.fr.
authors.forename: Claire
authors.initials: C
authors.lastname: Launois
authors.affiliation: Service des Maladies Respiratoires, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq Jay, 51092, Reims, Cedex, France. lboissiere@chu-reims.fr.
authors.forename: Louis
authors.initials: L
authors.lastname: Boissiere
authors.affiliation: Service d'Hépato-Gastro-Entérologie et Cancérologie Digestive, Hôpital Robert Debré, CHU de Reims, Reims, France. mbrasseur@chu-reims.fr.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Brasseur
authors.affiliation: Service des Maladies Respiratoires, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq Jay, 51092, Reims, Cedex, France. flebargy@chu-reims.fr.
authors.forename: François
authors.initials: F
authors.lastname: Lebargy
authors.affiliation: Service des Maladies Respiratoires, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq Jay, 51092, Reims, Cedex, France. gdeslee@chu-reims.fr.
authors.forename: Gaëtan
authors.initials: G
authors.lastname: Deslee
mesh_terms: D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000378:metabolism*; D006801:Humans; D033162:Incidental Findings; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000378:metabolism*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18