title: Impaired glucose metabolism treatment and carcinogenesis.
abstract: Carbohydrate metabolism disorders increase the risk of carcinogenesis. Diabetes mellitus alters numerous physiological processes that may encourage cancer growth. However, treating impaired glucose homeostasis may actually promote neoplasia; maintaining proper glucose plasma concentrations reduces metabolic stresses, however, certain medications may themselves result in oncogenic effects. A number of previous studies have demonstrated that metformin reduces the cancer risk. However, the use of sulfonylurea derivatives correlates with an increased risk of developing a malignancy. Another form of treatment, insulin therapy, involves using various forms of insulin that differ in pharmacodynamics, pharmacokinetics and efficacy. Previous studies have indicated that certain insulin variants also affect the cancer risk. The results from analyses that address the safety of long-lasting insulin types raise the most concern regarding the increased risk of malignancy. Rapid development of novel diabetic medications and their widespread use carries the risk of potentially increased rates of cancer, unnoticeable in limited, randomized, controlled trials. In the present review, the results of clinical and epidemiological studies are evaluated to assess the safety of anti-hyperglycemic medications and their effect on cancer risk and outcomes.
authors.affiliation: Department of Oncology, Military Institute of Medicine, Warsaw, Poland ; Department of Internal Medicine, Cardiology and Hypertensionr, L. Rydygier Province Hospital, Suwałki, Poland ; Department of Nephrology and Dialysis Center, L. Rydygier Province Hospital, Suwałki, Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Matyszewski
authors.affiliation: Department of Oncology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Czarnecka
authors.affiliation: Department of Oncology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Kawecki
authors.affiliation: Department of Oncology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Korzeń
authors.affiliation: Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Ilan J
authors.initials: IJ
authors.lastname: Safir
authors.affiliation: Department of Otorhinolaryngology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kukwa
authors.affiliation: Department of Oncology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Cezary
authors.initials: C
authors.lastname: Szczylik
keywords: carcinogenesis; diabetes; glargine; insulin resistance; metformin