title: An endoscope with integrated transparent bioelectronics and theranostic nanoparticles for colon cancer treatment.
abstract: The gastrointestinal tract is a challenging anatomical target for diagnostic and therapeutic procedures for bleeding, polyps and cancerous growths. Advanced endoscopes that combine imaging and therapies within the gastrointestinal tract provide an advantage over stand-alone diagnostic or therapeutic devices. However, current multimodal endoscopes lack the spatial resolution necessary to detect and treat small cancers and other abnormalities. Here we present a multifunctional endoscope-based interventional system that integrates transparent bioelectronics with theranostic nanoparticles, which are photoactivated within highly localized space near tumours or benign growths. These advanced electronics and nanoparticles collectively enable optical fluorescence-based mapping, electrical impedance and pH sensing, contact/temperature monitoring, radio frequency ablation and localized photo/chemotherapy, as the basis of a closed-loop solution for colon cancer treatment. In vitro, ex vivo and in vivo experiments highlight the utility of this technology for accurate detection, delineation and rapid targeted therapy of colon cancer or precancerous lesions.
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Hyunjae
authors.initials: H
authors.lastname: Lee
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Youngsik
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Changyeong
authors.initials: C
authors.lastname: Song
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|Department of Radiology, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.
authors.forename: Hye Rim
authors.initials: HR
authors.lastname: Cho
authors.affiliation: MC10 Inc., 9 Camp Street, Cambridge, Massachusetts 02140, USA.
authors.forename: Roozbeh
authors.initials: R
authors.lastname: Ghaffari
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Tae Kyu
authors.initials: TK
authors.lastname: Choi
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Kyung Hoon
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Young Bum
authors.initials: YB
authors.lastname: Lee
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.|Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China.
authors.forename: Daishun
authors.initials: D
authors.lastname: Ling
authors.affiliation: Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Republic of Korea.
authors.forename: Hyuk
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.
authors.forename: Su Jong
authors.initials: SJ
authors.lastname: Yu
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|Department of Radiology, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.
authors.forename: Seung Hong
authors.initials: SH
authors.lastname: Choi
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Taeghwan
authors.initials: T
authors.lastname: Hyeon
authors.affiliation: Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Dae-Hyeong
authors.initials: DH
authors.lastname: Kim
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D019723:Endoscopes; D004724:Endoscopy / Q000295:instrumentation; D006801:Humans; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D000068936:Theranostic Nanomedicine / Q000295:instrumentation* / Q000379:methods
chemical_list: D000970:Antineoplastic Agents