title: The lost correlation between heat shock protein 70 (HSPA1A) and plasminogen activator inhibitor-1 in patients with type 2 diabetes and albuminuria.
abstract: We aimed to study the relation between plasma levels of stress-induced heat shock protein 70 (HSPA1A) with plasminogen activator inhibitor-1 (PAI-1) and high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (Apo-A1), and HDL-C/Apo-A1 ratio. In a matched case-control study on patients with diabetes (40 patients with albuminuria and 40 without albuminuria matched for age, sex, and body mass index), we observed that plasma levels of HSPA1A and PAI-1 are increased in patients with albuminuria (0.55 ± 0.02 vs. 0.77 ± 0.04 ng/ml, p value <0.001 for HSPA1A; 25.9 ± 2 vs. 31.8 ± 2.4 ng/ml, p value <0.05 for PAI-1). There was a significant correlation between HSPA1A and PAI-1 in diabetic patients without albuminuria (r = 0.28; p value = 0.04), but not in those with albuminuria (r = 0.07; p value = 0.63). No association was found between HSPA1A and HDL-C, between HSPA1A and Apo-A1, or between HSPA1A and HDL-C/Apo-A1 ratio. We concluded that there is a direct correlation between plasma HSPA1A and PAI-1 levels in patients with diabetes, which is lost when they develop albuminuria.
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran. arash.aan@gmail.com.
authors.forename: Arash Aghajani
authors.initials: AA
authors.lastname: Nargesi
authors.affiliation: Department of Orthodontics, Faculty of Dentistry, Guilan University of Medical Sciences, Rasht, Guilan, Iran. majid.shalchi@yahoo.com.
authors.forename: Majid
authors.initials: M
authors.lastname: Shalchi
authors.affiliation: Department of Prosthodontics, Faculty of Dentistry, Guilan University of Medical Sciences, Rasht, Guilan, Iran. r.nargesi@yahoo.com.
authors.forename: Reihaneh Aghajani
authors.initials: RA
authors.lastname: Nargesi
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran. niloofarsadeghpour777@gmail.com.
authors.forename: Niloofar
authors.initials: N
authors.lastname: Sadeghpour
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran. m_zarifkar@yahoo.com.
authors.forename: Mitra
authors.initials: M
authors.lastname: Zarifkar
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran. dr.majid42@gmail.com.
authors.forename: Majid
authors.initials: M
authors.lastname: Mozaffari
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran. dr.m.imani@hotmail.com.
authors.forename: Mehrnaz
authors.initials: M
authors.lastname: Imani
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran. esteghamati@tums.ac.ir.
authors.forename: Alireza
authors.initials: A
authors.lastname: Esteghamati
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran. nakhjavanim@tums.ac.ir.
authors.forename: Manouchehr
authors.initials: M
authors.lastname: Nakhjavani
mesh_terms: D000419:Albuminuria / Q000097:blood* / Q000150:complications*; D016632:Apolipoprotein A-I / Q000097:blood; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications*; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*
chemical_list: C505693:APOA1 protein, human; D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D018840:HSP70 Heat-Shock Proteins; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human
keywords: Albuminuria; Diabetes; Heat shock protein 70; High-density lipoprotein; Plasminogen activator inhibitor-1