title: Chlorpyrifos chronic toxicity in broilers and effect of vitamin C.
abstract: An experiment was conducted to study chlorpyrifos chronic toxicity in broilers and the protective effect of vitamin C. Oral administration of 0.8 mg/kg body weight (bw) (1/50 LD50) chlorpyrifos (Radar(®)), produced mild diarrhea and gross lesions comprised of paleness, flaccid consistency and slightly enlargement of liver. Histopathologically, chlorpyrifos produced degenerative changes in various organs. Oral administration of 100 mg/kg bw vitamin C partially ameliorated the degenerative changes in kidney and heart. There was insignificant alteration in biochemical and haematological profiles. It is concluded that supplementation of vitamin C reduced the severity of lesions induced by chronic chlorpyrifos toxicity in broilers.
authors.affiliation: Department of Poultry and Fish Diseases, Faculty of Veterinary Medicine, Al-Fateh University, Tripoli, Libya.
authors.forename: A M
authors.initials: AM
authors.lastname: Kammon
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana, India.
authors.forename: R S
authors.initials: RS
authors.lastname: Brar
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana, India.
authors.forename: S
authors.initials: S
authors.lastname: Sodhi
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana, India.
authors.forename: H S
authors.initials: HS
authors.lastname: Banga
authors.affiliation: Department of Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Singh
authors.affiliation: Department of Livestock Production and Management, College of Veterinary Science, GADVASU, Ludhiana, India.
authors.forename: N S
authors.initials: NS
authors.lastname: Nagra
keywords: broilers; chlorpyrifos; chronic toxicity; clinicopathology; vitamin C