title: Association between interleukin-17 gene polymorphisms and risk of coronary artery disease.
abstract: We conducted a case-control study to estimate the association between IL-17A rs2275913, rs3819025 and rs3748067 polymorphisms and development of coronary artery disease. A total of 415 patients with coronary artery disease and 448 health controls were recruited during the period of March 2013 and October 2014. Genotyping of IL-17A rs2275913, rs3819025 and rs3748067 were analyzed by polymerase chain reaction coupled with restriction fragment length polymorphism. By logistic regression analysis, we found that individuals with the AA genotype (OR, 2.18; 95% CI, 1.35-3.56) and the GA+AA genotype (OR, 1.39, 95% CI, 1.06-1.84) of rs2275913 were associated with an increased risk of coronary artery disease when compared with the GG genotype. Individuals carrying the GA+AA genotype of rs2275913 were more likely to have a higher risk of coronary artery disease in those with hypertension and smoking habit, and the adjusted ORs (95% CI) were 3.92 (2.13-6.82) and 2.74 (1.71-4.40). In conclusion, we suggest that individuals with the AA genotype and the GA+AA genotype of rs2275913 are associated with an increased risk of coronary artery disease, especially in those with hypertension and smoking habit.
authors.affiliation: Department of Cardiovascular, Zhujiang Hospital, Southern Medical University Guangzhou 510280, China ; Department of Emergency, Affiliated Hospital of Inner Mongolia Medical University Hohhot 010051, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Shuang
authors.affiliation: Department of Cardiovascular, Zhujiang Hospital, Southern Medical University Guangzhou 510280, China.
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Emergency, Affiliated Hospital of Inner Mongolia Medical University Hohhot 010051, China.
authors.forename: Fengying
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Emergency, Affiliated Hospital of Inner Mongolia Medical University Hohhot 010051, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Cui
authors.affiliation: Department of Emergency, Affiliated Hospital of Inner Mongolia Medical University Hohhot 010051, China.
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Ning
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Inner Mongolia Medical University Hohhot 010051, China.
authors.forename: Youle
authors.initials: Y
authors.lastname: Su
authors.affiliation: Department of Orthopedic Medicine, The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot 010030, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Dong
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications; D020381:Interleukin-17 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012907:Smoking / Q000009:adverse effects
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17
keywords: Interleukin-17; coronary artery disease; polymorphism