title: Recent decline in prostate cancer incidence in the United States, by age, stage, and Gleason score.
abstract: Prostate cancer incidence is sensitive to screening practices, however the impact of recent screening recommendations from the United States Preventative Services Task Force on prostate cancer incidence by age, stage, race, and Gleason score is unknown. This study described the timing and magnitude of changes in prostate cancer incidence trends in the United States by month of diagnosis, and evaluated trends by age, Gleason score, and stage at diagnosis. We analyzed prostate cancer incidence trends using Surveillance, Epidemiology, and End Results (SEER) program data for men diagnosed with invasive prostate cancer from 2007 through 2012. JoinPoint analysis was used to detect changes in the rate of annual percent change (APC) in prostate cancer incidence for all diagnoses and by age, Gleason score, race, and stage. Prostate cancer incidence declined at an estimated -19.6% APC beginning May 2011. This decline was observed in all age groups. Low-grade tumors (Gleason score ≤6) showed a steeper decline (-29.1% APC) than high-grade tumors (Gleason score 8-10: -10.8% APC). Only stage I/II and stage III tumors saw declines (-24.2% and -16.7% APC, respectively). A sharp decline in prostate cancer incidence began before release of the United States Preventative Services Task Force October 2011 draft and May 2012 final screening recommendation. The greatest change occurred with incidence of low-grade tumors, although there is concern that some high-grade tumors may now go undetected.
authors.affiliation: Utah Cancer Registry, University of Utah, Salt Lake City, Utah.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Herget
authors.affiliation: Division of Urology, Department of Surgery, University of Utah, Salt Lake City, Utah.|Huntsman Cancer Institute, Salt Lake City, Utah.
authors.forename: Darshan P
authors.initials: DP
authors.lastname: Patel
authors.affiliation: Huntsman Cancer Institute, Salt Lake City, Utah.|Division of Public Health, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah.
authors.forename: Heidi A
authors.initials: HA
authors.lastname: Hanson
authors.affiliation: Utah Cancer Registry, University of Utah, Salt Lake City, Utah.|Huntsman Cancer Institute, Salt Lake City, Utah.|Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah.
authors.forename: Carol
authors.initials: C
authors.lastname: Sweeney
authors.affiliation: Division of Urology, Department of Surgery, University of Utah, Salt Lake City, Utah.|Huntsman Cancer Institute, Salt Lake City, Utah.
authors.forename: William T
authors.initials: WT
authors.lastname: Lowrance
mesh_terms: D017677:Age Distribution; D006801:Humans; D015994:Incidence; D008297:Male; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011159:Population Surveillance; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D018426:SEER Program; D014481:United States / Q000453:epidemiology
keywords: Early detection of cancer; SEER program; incidence; prostate specific antigen; prostatic neoplasms; trends