title: A potential oral anticancer drug candidate,Moringa oleiferaleaf extract, induces the apoptosis of human hepatocellular carcinoma cells.
abstract: It has previously been reported that cold water-extracts ofMoringa oleiferaleaf have anticancer activity against various human cancer cell lines, including non-small cell lung cancer. In the present study, the anticancer activity ofM. oleiferaleaf extracts was investigated in human hepatocellular carcinoma HepG2 cells. By the analysis of apoptotic signals, including the induction of caspase or poly(ADP-ribose) polymerase cleavage, and the Annexin V and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assays, it was demonstrated thatM. oleiferaleaf extracts induce the apoptosis of HepG2 cells. In the hollow fiber assay, oral administration of the leaf extracts significantly reduced (44-52%) the proliferation of the HepG2 cells and A549 non-small cell lung cancer cells. These results support the potential of soluble extracts ofM. oleiferaleaf as orally administered therapeutics for the treatment of human liver and lung cancers.
authors.affiliation: Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, Daejeon, Republic of Korea.
authors.forename: Il Lae
authors.initials: IL
authors.lastname: Jung
authors.affiliation: Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, Daejeon, Republic of Korea.
authors.forename: Ju Hye
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Life Science, Gachon University, Seongnam, Gyeonggi, Republic of Korea.
authors.forename: Se Chan
authors.initials: SC
authors.lastname: Kang
keywords: Moringa oleifera; anticancer drug; apoptosis; hepatocellular carcinoma cells; lung cancer