title: Adult systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease: A case report.
abstract: Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disease (EBV+T-LPD) occurs mainly in Asia and South America and is extremely rare in adults. The disease is characterized by a clonal proliferation of EBV-infected T cells with a cytotoxic immunophenotype and is associated with a poor clinical outcome and can be life-threatening. The majority of the patients have evidence of systemic disease, often with lymph node, liver and spleen involvement. The present study describes a case of adult systemic EBV+T-LPD with high fever, systemic lymphadenopathy, hepatosplenomegaly, nose-pharynx neoplasm, pancytopenia, EB virus infection and proliferative bone marrow, with the aim of improving the understanding of the condition.
authors.affiliation: Department of Oncology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China.
authors.forename: Youping
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Hematology, The Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
authors.forename: Xinyue
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Hematology, The Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
keywords: Epstein-Barr virus; infectious mononucleosis; lymphoproliferative disease; natural killer/T-cell lymphoma