title: Ectopic hamartomatous thymoma: report of a case and review of literature.
abstract: Ectopic hamartomatous thymoma (EHT) is an exceedingly rare lesion that usually arises in the lower neck and mainly affects adult men. We present the clinicopathological features of a case of EHT in a 28-year-old Chinese male, together with a literature review. Ultrasound imaging and a computed tomography (CT) scan of the neck demonstrated a 3.0-cm well-defined nodule of heterogeneous density located within the left sternocleidomastoid muscle. The patient underwent a gross total resection of the tumor. Grossly, the well-demarcated, encapsulated mass had a predominantly solid and gray-white appearance admixed with microcystic foci filled with serous content and yellowish regions. The lesion consisted of an irregular admixture of spindle cells, epithelium, and mature adipose tissue. Immunohistochemistry showed that both the spindle cell and epithelial components were diffuse and had intense nuclear positivity for p63 and cytoplasmic reactivity for pan-cytokeratin, CK7, and CK19. The patient was followed for 18 months without any evidence of metastasis or recurrence.
authors.affiliation: Department of Pathology, The General Hospital, Jinan Military Command Jinan 250031, Shandong Province, China.
authors.forename: Hongbiao
authors.initials: H
authors.lastname: Jing
authors.affiliation: Department of Pathology, The Fourth People Hospital of Jinan City Jinan 250031, Shandong Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: The Sixth People Hospital of Jinan City Zhangqiu 250200, Shandong Province, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wei
authors.affiliation: The Sixth People Hospital of Jinan City Zhangqiu 250200, Shandong Province, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Liu
authors.affiliation: The Sixth People Hospital of Jinan City Zhangqiu 250200, Shandong Province, China.
authors.forename: Fangshu
authors.initials: F
authors.lastname: Chen
authors.affiliation: The Sixth People Hospital of Jinan City Zhangqiu 250200, Shandong Province, China.
authors.forename: Qingda
authors.initials: Q
authors.lastname: Meng
authors.affiliation: Department of Pathology, The General Hospital, Jinan Military Command Jinan 250031, Shandong Province, China ; Department of Pathology, 307 Hospital of PLA Beijing, China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Tai
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002828:Choristoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006222:Hamartoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006258:Head and Neck Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D013945:Thymoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013961:Thyroid Gland; D013964:Thyroid Neoplasms; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor
keywords: Ectopic hamartomatous thymoma; neck; thymoma; tumor