title: Association of Adiponectin gene polymorphisms and nonalcoholic fatty liver disease.
abstract: OBJECTIVE
  To investigate the correlation between Adiponectin gene polymorphisms and the genetic susceptibility of nonalcoholic fatty liver disease (NAFLD).
  
  
  METHODS
  357 NAFLD patients from January 2005 to December 2013 and 357 cases of healthy controls among the Han population were collected; polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect three tagSNPs (Rs2241767, rsl501299 and rs3774261) of Adiponectin. Risk factors were analyzed by multivariate logistic regression and haplotype analysis was performed using SHEsis software.
  
  
  RESULTS
  Rs2241767, rsl501299 and rs3774261 polymorphisms were associated with the risk of NAFLD. Haplotype analysis showed that, A-T-A haplotype was a protective factor of NAFLD (OR: 0.154, 95% CI: 0.011-0.576, P = 0.004) and G-G-A (OR: 4.012, 95% CI: 2.118-10.324, P < 0.001) and G-T-G (OR: 5.219, 95% CI: 2.751-12.651, P < 0.001) haplotype was risk factors of NAFLD.
  
  
  CONCLUSIONS
  There was an association between Adiponectin gene polymorphisms and the genetic susceptibility of NAFLD.
authors.affiliation: Grade 2015, Graduate School of Medical College, Shanghai Jiaotong University Shanghai 20025, China.
authors.forename: Hong-Jue
authors.initials: HJ
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Affiliated Hospital, Luzhou Medical College Sichuan Province, 646000, China.
authors.forename: Chang-Ping
authors.initials: CP
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Affiliated Hospital, Luzhou Medical College Sichuan Province, 646000, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Affiliated Hospital, Luzhou Medical College Sichuan Province, 646000, China.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Zhong
authors.affiliation: Department of Gastroenterology, Affiliated Hospital, Luzhou Medical College Sichuan Province, 646000, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
keywords: Adiponectin; NAFLD; gene polymorphism