title: Insulin sensitivity affects corticolimbic brain responses to visual food cues in polycystic ovary syndrome patients.
abstract: BACKGROUND
  This study examined the effect of insulin sensitivity on the responsiveness of appetite regulatory brain regions to visual food cues.
  
  
  METHODS
  Nineteen participants diagnosed with polycystic ovary syndrome (PCOS) were divided into insulin-sensitive (n=8) and insulin-resistant (n=11) groups based on the homeostatic model assessment of insulin resistance (HOMA2-IR). Subjects underwent functional magnetic resonance imaging (fMRI) while viewing food pictures following water or dextrose consumption. The corticolimbic blood oxygen level dependent (BOLD) responses to high-calorie (HC) or low-calorie (LC) food pictures were compared within and between groups.
  
  
  RESULTS
  BOLD responses to food pictures were reduced during a glucose challenge in numerous corticolimbic brain regions in insulin-sensitive but not insulin-resistant subjects. Furthermore, the degree of insulin resistance positively correlated with the corticolimbic BOLD response in the medial prefrontal cortex (mPFC), orbitofrontal cortex (OFC), anterior cingulate and ventral tegmental area (VTA) in response to HC pictures, and in the dorsolateral prefrontal cortex (DLPFC), mPFC, anterior cingulate, and insula in response to LC pictures following a glucose challenge. BOLD signal in the OFC, midbrain, hippocampus, and amygdala following a glucose challenge correlated with HOMA2-IR in response to HC-LC pictures.
  
  
  CONCLUSIONS
  We conclude that the normal inhibition of corticolimbic brain responses to food pictures during a glucose challenge is compromised in insulin-resistant subjects. The increase in brain responsiveness to food pictures during postprandial hyperinsulinemia may lead to greater non-homeostatic eating and perpetuate obesity in insulin-resistant subjects.
authors.forename: Hanin M
authors.initials: HM
authors.lastname: Alsaadi
authors.forename: Dean A
authors.initials: DA
authors.lastname: Van Vugt
mesh_terms: D000293:Adolescent; D000328:Adult; D001069:Appetite Regulation; D015992:Body Mass Index; D003463:Cues; D015536:Down-Regulation; D005260:Female; D005502:Food; D059907:Functional Neuroimaging; D006801:Humans; D007333:Insulin Resistance; D065726:Limbic Lobe / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D009474:Neurons / Q000378:metabolism*; D009765:Obesity / Q000150:complications; D050177:Overweight / Q000150:complications; D010775:Photic Stimulation; D010781:Photography; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000378:metabolism*; D055815:Young Adult