title: Nosocomial transmission of multidrug-resistant tuberculosis.
abstract: Nosocomial transmission of multidrug-resistant tuberculosis (MDR-TB) was ascertained by 24-locus mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) and spoligotyping at four hospitals in the Republic of Moldova, a high MDR-TB burden country. Overall, 5.1% of patients with pan-susceptible TB at baseline were identified with MDR-TB during in-patient treatment. In 75% of cases, the MDR-TB strain was genetically distinct from the non-MDR-TB strain at baseline, suggesting a high rate of nosocomial transmission of MDR-TB. The highest proportion (40.3%) of follow-up MDR-TB isolates was associated with the M. tuberculosis URAL 163-15 strain.
authors.affiliation: Institute of Phthisiopneumology, Chisinau, Republic of Moldova.
authors.forename: V
authors.initials: V
authors.lastname: Crudu
authors.affiliation: Division of Molecular Mycobacteriology and German Center for Infection Research (DZIF) Tuberculosis Unit, Borstel, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Merker
authors.affiliation: DZIF Tuberculosis Unit, Research Center Borstel, Borstel, Germany; Department of Medicine, University of Namibia School of Medicine, Windhoek, Namibia; Department of Medicine, Karolinska Institute, Stockholm, Sweden; Department of Pneumology & Allergology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.
authors.forename: C
authors.initials: C
authors.lastname: Lange
authors.affiliation: Institute of Phthisiopneumology, Chisinau, Republic of Moldova.
authors.forename: E
authors.initials: E
authors.lastname: Noroc
authors.affiliation: Institute of Phthisiopneumology, Chisinau, Republic of Moldova.
authors.forename: E
authors.initials: E
authors.lastname: Romancenco
authors.affiliation: Department of Pneumology & Allergology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.
authors.forename: D
authors.initials: D
authors.lastname: Chesov
authors.affiliation: DZIF Tuberculosis Unit, Research Center Borstel, Borstel, Germany; Department of Medicine, University of Namibia School of Medicine, Windhoek, Namibia.
authors.forename: G
authors.initials: G
authors.lastname: Günther
authors.affiliation: Division of Molecular Mycobacteriology and German Center for Infection Research (DZIF) Tuberculosis Unit, Borstel, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Niemann
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D016000:Cluster Analysis; D003428:Cross Infection / Q000188:drug therapy / Q000635:transmission*; D024901:Drug Resistance, Multiple, Bacterial; D005838:Genotype; D006801:Humans; D018598:Minisatellite Repeats; D008966:Moldova; D009169:Mycobacterium tuberculosis / Q000235:genetics; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000635:transmission*
chemical_list: D000995:Antitubercular Agents