title: Microwave Heating of Poly(N-isopropylacrylamide)-Conjugated Gold Nanoparticles for Temperature-Controlled Display of Concanavalin A.
abstract: We demonstrate microwave-induced heating of gold nanoparticles and nanorods. An appreciably higher and concentration-dependent microwave-induced heating rate was observed with aqueous dispersions of the nanomaterials as opposed to pure water and other controls. Grafted with the thermoresponsive polymer poly(N-isopropylacrylamide), these gold nanomaterials react to microwave-induced heating with a conformational change in the polymer shell, leading to particle aggregation. We subsequently covalently immobilize concanavalin A (Con A) on the thermoresponsive gold nanoparticles. Con A is a bioreceptor commonly used in bacterial sensors because of its affinity for carbohydrates on bacterial cell surfaces. The microwave-induced thermal transitions of the polymer reversibly switch on and off the display of Con A on the particle surface and hence the interactions of the nanomaterials with carbohydrate-functionalized surfaces. This effect was determined using linear sweep voltammetry on a methyl-α-d-mannopyranoside-functionalized electrode.
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia , Mawson Lakes, South Australia 5095, Australia.
authors.forename: Roshan B
authors.initials: RB
authors.lastname: Vasani
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia , Mawson Lakes, South Australia 5095, Australia.
authors.forename: Nayana
authors.initials: N
authors.lastname: Janardanan
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia , Mawson Lakes, South Australia 5095, Australia.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Prieto-Simón
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia , Mawson Lakes, South Australia 5095, Australia.
authors.forename: Anna
authors.initials: A
authors.lastname: Cifuentes-Rius
authors.affiliation: Future Industries Institute, University of South Australia , Mawson Lakes, South Australia 5095, Australia.
authors.forename: Siobhan J
authors.initials: SJ
authors.lastname: Bradley
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia , Mawson Lakes, South Australia 5095, Australia.
authors.forename: Eli
authors.initials: E
authors.lastname: Moore
authors.affiliation: INM-Leibniz Institute for New Materials , Campus D2 2, Saarbruecken, Saarland 66123, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Kraus
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia , Mawson Lakes, South Australia 5095, Australia.
authors.forename: Nicolas H
authors.initials: NH
authors.lastname: Voelcker
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry*; D003208:Concanavalin A / Q000138:chemical synthesis / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D008872:Microwaves; D010316:Particle Size; D013499:Surface Properties; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D003208:Concanavalin A; C052970:poly-N-isopropylacrylamide; D006046:Gold
keywords: concanavalin A; controlled display; gold nanoparticles; microwave heating; poly(N-isopropylacrylamide)