title: Two New Flavonol Glycosides from Polygala sibirica L. var megalopha Fr.
abstract: Two new flavonol glycosides, named polygalin H (1) and polygalin I (2), as well as the known compound polygalin D (3), were isolated from the whole plant of Polygala sibirica L. var megalopha Fr. Their structures were elucidated on the basis of spectroscopic data analysis. These flavonol glycosides exhibited strong inhibitory activities against xanthine oxidase in vitro. Their half-maximal inhibitory concentrations (IC50) were calculated, which were 9.48, 8.31, 16.00 μM, respectively.
authors.affiliation: College of Forestry, Southwest Forestry University, Kunming 650224, Yunnan, China. hyj0106@foxmail.com.
authors.forename: Yan-Jie
authors.initials: YJ
authors.lastname: Huang
authors.affiliation: College of Forestry, Southwest Forestry University, Kunming 650224, Yunnan, China. zly324@foxmail.com.|School of Pharmacy, Wannan Medical College, Wuhu 241002, Anhui, China. zly324@foxmail.com.
authors.forename: Ling-Yun
authors.initials: LY
authors.lastname: Zhou
authors.affiliation: College of Forestry, Southwest Forestry University, Kunming 650224, Yunnan, China. dawn723@163.com.
authors.forename: Jun-Min
authors.initials: JM
authors.lastname: Wang
authors.affiliation: College of Forestry, Southwest Forestry University, Kunming 650224, Yunnan, China. kib312270163@foxmail.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: College of Forestry, Southwest Forestry University, Kunming 650224, Yunnan, China. 18208826431@163.com.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Geng
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China. haiyangliu@mail.kib.ac.cn.
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Liu
authors.affiliation: College of Forestry, Southwest Forestry University, Kunming 650224, Yunnan, China. huayan1216@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hua
mesh_terms: D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D044948:Flavonols / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification*; D066298:In Vitro Techniques; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology*; D031801:Polygala / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D044948:Flavonols; D006027:Glycosides; D010936:Plant Extracts; C000610633:polygalin H; C000610634:polygalin I; D014969:Xanthine Oxidase
keywords: Polygala sibirica; Polygalaceae; flavonol glycosides; inhibition of xanthine oxidase