title: Proliferative Glomerulonephritis With Monoclonal IgG1κ Deposits in a Hepatitis C Virus-Positive Patient.
abstract: Hepatitis C virus infection is associated with several glomerular diseases, most commonly cryoglobulinemic glomerulonephritis, which is typically secondary to type II mixed cryoglobulinemia. We present a patient with hepatitis C virus infection and cryoglobulinemic glomerulonephritis secondary to type I (monoclonal) cryoglobulinemia that is likely related to a concurrent hepatitis C virus infection-associated lymphoproliferative disorder. We list the differential diagnosis of cryoglobulinemic glomerulonephritis. Additionally, the case draws attention to the possibility that, rarely, even clinically undetectable "occult" B-cell lymphoproliferative disorders may result in significant kidney disease.
authors.affiliation: Department of Pathology, The Ohio State University, Columbus, OH.
authors.forename: Jessica
authors.initials: J
authors.lastname: Hemminger
authors.affiliation: Kidney Care Specialists, LLC, Kettering, OH.
authors.forename: Madhu
authors.initials: M
authors.lastname: Kandarpa
authors.affiliation: Kidney Care Specialists, LLC, Kettering, OH.
authors.forename: Arthur
authors.initials: A
authors.lastname: Tsai
authors.affiliation: Department of Pathology, The Ohio State University, Columbus, OH. Electronic address: tibor.nadasdy@osumc.edu.
authors.forename: Tibor
authors.initials: T
authors.lastname: Nadasdy
mesh_terms: D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D008875:Middle Aged
chemical_list: D007074:Immunoglobulin G
keywords: Proliferative glomerulonephritis; cryoglobulinemia; hepatitis C virus (HCV); kidney biopsy; monoclonal IgG deposits; occult B cell lymphoproliferative disorder