title: IκBζ: A key protein in the pathogenesis of psoriasis.
abstract: Psoriasis is an immune-mediated chronic inflammatory skin disease with a complex etiology. The proinflammatory cytokine IL-17A is known to play key role in the pathogenesis of psoriasis, and recently anti-IL-17A antibodies have been approved for psoriasis treatment. Here, we discuss our recent findings demonstrating that IκBζ, a transcriptional co-activator, plays a crucial role in the development of psoriasis by mediating IL-17A-driven effects. These findings have significant implications as they uncover a novel crucial regulatory mechanism involved in psoriasis development, and identify IκBζ as a possible future target in the treatment of psoriasis and other IL-17A-driven diseases.
authors.affiliation: Department of Dermatology, Aarhus University Hospital, 8000 Aarhus C, Denmark.
authors.forename: Claus
authors.initials: C
authors.lastname: Johansen
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D030801:Animals, Genetically Modified; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D020672:I-kappa B Proteins / Q000172:deficiency / Q000235:genetics* / Q000378:metabolism*; D007249:Inflammation; D020381:Interleukin-17 / Q000378:metabolism; D015603:Keratinocytes / Q000378:metabolism; D051379:Mice; D009687:Nuclear Proteins / Q000172:deficiency / Q000235:genetics* / Q000378:metabolism*; D011565:Psoriasis / Q000276:immunology* / Q000503:physiopathology*; D015398:Signal Transduction
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D016207:Cytokines; D020672:I-kappa B Proteins; C508717:IL17A protein, human; D020381:Interleukin-17; C417234:NFKBIZ protein, human; D009687:Nuclear Proteins
keywords: IL-17A; Inflammation; IκBζ; Keratinocytes; Psoriasis