title: [DRUGS-INDUCED URTICARIA AND ANGIOEDEMA].
abstract: Drug-induced urticaria and/or angioedema is a frequent issue encountered in family medicine. A specific collection of the anamnesis and of the general context is very important to appreciate the involved mechanism, allergic or not, and potential cofactors. If in doubt about an allergic mechanism, tests will be conducted, mostly under a hospital setting. Bradykinin-mediated angioedema, so much rare than histamine-mediated one, has to be known, because it is potentially lethal. It is often iatrogenic (ACE inhibitors especially). At the end of the allergology work-up, a course of action is proposed to the patient and his family practitioner as far as the rechallenge of the drug is concerned, In case of non-allergic urticaria, much more frequent than allergy, taking the drug is possible with a premedication with antihistamines.
authors.forename: Marion
authors.initials: M
authors.lastname: Braire-Bourrel
authors.forename: Frédéric
authors.initials: F
authors.lastname: Augey
authors.forename: Marie-Sylvie
authors.initials: MS
authors.lastname: Doutre
mesh_terms: D000799:Angioedema / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects; D001920:Bradykinin / Q000378:metabolism; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006632:Histamine / Q000378:metabolism; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D014581:Urticaria / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D006633:Histamine Antagonists; D006632:Histamine; D001920:Bradykinin