title: The Effect of Infection Control Nurses on the Occurrence of Pseudomonas aeruginosa Healthcare-Acquired Infection and Multidrug-Resistant Strains in Critically-Ill Children.
abstract: BACKGROUND
  Healthcare-acquired Pseudomonas aeruginosa (P. aeruginosa) infections in the Pediatric Intensive Care Unit (PICU), which have a high incidence, increase treatment costs and mortality, and seriously threaten the safety of critically ill children. It is essential to seek convenient and effective methods to control and prevent healthcare-acquired infections (HAIs). This research was conducted to study the effect of infection control nurses on the occurrence of P. aeruginosa HAIs and multi-drug resistance (MDR) strains in PICU.
  
  
  METHODS
  The clinical data was divided into two groups, with the age ranging from 1 month to 14 years. One group of the critically ill patients(N = 3,722) was admitted to PICU from 2007 to 2010, without the management of infection control nurses. The other group of the critically ill patients (N = 3,943) was admitted to PICU from 2011 to 2013, with the management of infection control nurses. Compare the mortality, morbidity and the incidence of acquired P. aeruginosa infections to evaluate the effect of infection control nurses.
  
  
  RESULTS
  After implementation of the post of infection control nurses, the patient's overall mortality fell from 4.81% to 3.73%. Among the patients with endotracheal intubation more than 48 hours, the incidence of endotracheal intubation-related pneumonia decreased from 44.6% to 34.32%. The mortality of patients with endotracheal intubation decreased from 16.96% to 10.17%, and the morbidity of HAIs with P. aeruginosa decreased from 1.89% to 1.07%. The mutual different rate (MDR) dropped from 67.95% to 44.23%. There were remarkable differences in these rates between the two groups (p<0.05).
  
  
  CONCLUSIONS
  Implementing the post of infection control nurses is associated with effectively reducing the HAI rate, especially the incidence and morbidity of P. aeruginosa HAIs, reducing PICU mortality, improving P. aeruginosa drug resistance.
authors.affiliation: Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Linxi
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Rong
authors.affiliation: Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Yongyan
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Wenliang
authors.initials: W
authors.lastname: Song
authors.affiliation: Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D016638:Critical Illness / Q000451:nursing*; D003428:Cross Infection / Q000209:etiology / Q000451:nursing* / Q000517:prevention & control*; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D007223:Infant; D017053:Infection Control; D015278:Intensive Care Units, Pediatric; D007442:Intubation, Intratracheal / Q000009:adverse effects; D008297:Male; D024802:Nurse's Role; D011552:Pseudomonas Infections / Q000209:etiology / Q000451:nursing* / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents