title: Not low hanging but still sweet: Metabolic proteomes in cardiovascular disease.
abstract: The application of proteomics in biology and medicine has reached a moment of truth. The demand of biologists for transformative insights into how cells work, plus the mandate of basic science research to ultimately impact clinical medicine, crystallize as a test on the rigor and reproducibility of any 'omics measurement. Studies like that by Boylston et al. indicate that proteomics can pass that test.
authors.affiliation: Department of Anesthesiology, David Geffen School of Medicine, UCLA, United States; Department of Medicine/Cardiology, David Geffen School of Medicine, UCLA, United States.
authors.forename: Emma
authors.initials: E
authors.lastname: Monte
authors.affiliation: Department of Anesthesiology, David Geffen School of Medicine, UCLA, United States; Department of Medicine/Cardiology, David Geffen School of Medicine, UCLA, United States.
authors.forename: Rachel
authors.initials: R
authors.lastname: Lopez
authors.affiliation: Department of Anesthesiology, David Geffen School of Medicine, UCLA, United States; Department of Medicine/Cardiology, David Geffen School of Medicine, UCLA, United States. Electronic address: tvondriska@mednet.ucla.edu.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Vondriska
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D056564:Sirtuin 1 / Q000235:genetics*; D019802:Succinic Acid / Q000378:metabolism*
chemical_list: D019802:Succinic Acid; D056564:Sirtuin 1
keywords: Heart disease; Heart failure; Ischemia; Metabolism; Mitochondria; Myocardial; Proteomics; Systems biology