title: Chitosan as a starting material for wound healing applications.
abstract: Chitosan and its derivatives have attracted great attention due to their properties beneficial for application to wound healing. The main focus of the present review is to summarize studies involving chitosan and its derivatives, especially N,N,N-trimethyl-chitosan (TMC), N,O-carboxymethyl-chitosan (CMC) and O-carboxymethyl-N,N,N-trimethyl-chitosan (CMTMC), used to accelerate wound healing. Moreover, formulation strategies for chitosan and its derivatives, as well as their in vitro, in vivo and clinical applications in wound healing are described.
authors.affiliation: School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, 1211 Geneva, Switzerland; West University of Timisoara, Department of Biology-Chemistry, Pestalozzi 16, Timisoara 300115, Romania; West University of Timisoara, Advanced Environmental Research Laboratories, Oituz 4, Timisoara 300086, Romania.
authors.forename: V
authors.initials: V
authors.lastname: Patrulea
authors.affiliation: West University of Timisoara, Department of Biology-Chemistry, Pestalozzi 16, Timisoara 300115, Romania; West University of Timisoara, Advanced Environmental Research Laboratories, Oituz 4, Timisoara 300086, Romania.
authors.forename: V
authors.initials: V
authors.lastname: Ostafe
authors.affiliation: School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, 1211 Geneva, Switzerland. Electronic address: gerrit.borchard@unige.ch.
authors.forename: G
authors.initials: G
authors.lastname: Borchard
authors.affiliation: School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, 1211 Geneva, Switzerland.
authors.forename: O
authors.initials: O
authors.lastname: Jordan
mesh_terms: D000818:Animals; D001458:Bandages; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D020100:Hydrogels; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D020100:Hydrogels; D048271:Chitosan
keywords: Biopolymers; Carboxymethyl chitosan; Chitosan; Chitosan (PubChem CID: 21896651); Chitosan derivatives; Drug delivery; Polyelectrolytes; Skin regeneration; Trimethyl chitosan; Wound dressings; Wound healing