title: Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease.
abstract: The objective of our study was to investigate the association of two single nucleotide polymorphisms (SNPs) with genetic risk of dementia. In 212 patients with Parkinson's disease (PD), we investigated two polymorphisms within the G-protein coupled receptor kinase 5 (GRK5) gene (rs2420616, rs4752293) to determine a possible risk factor for dementia. We identified two alleles most significantly present in PD patients with dementia: G and T alleles. We also identified risk haplotypes: GC, and AT. We demonstrated that the SNPs and the related haplotypes could play a central role in predisposing PD patients to cognitive impairment.
authors.affiliation: Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy. Electronic address: g.nicoletti@unicz.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nicoletti
authors.affiliation: Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Luca
authors.affiliation: Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Tarantino
authors.affiliation: Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy; Institute of Neurology, University "Magna Graecia", Catanzaro, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Gagliardi
authors.affiliation: Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy; Institute of Neurology, University "Magna Graecia", Catanzaro, Italy.
authors.forename: Grazia
authors.initials: G
authors.lastname: Iannello
authors.affiliation: Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Novellino
authors.affiliation: Institute of Neurology, University "Magna Graecia", Catanzaro, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Morelli
authors.affiliation: Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy.
authors.forename: Grazia
authors.initials: G
authors.lastname: Annesi
authors.affiliation: Neuroimaging Research Unit, IBFM-CNR, Catanzaro, Italy; Institute of Neurology, University "Magna Graecia", Catanzaro, Italy.
authors.forename: Aldo
authors.initials: A
authors.lastname: Quattrone
mesh_terms: D000368:Aged; D000483:Alleles; D003072:Cognition Disorders / Q000209:etiology / Q000235:genetics*; D003704:Dementia / Q000209:etiology / Q000235:genetics*; D005260:Female; D054774:G-Protein-Coupled Receptor Kinase 5 / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D054774:G-Protein-Coupled Receptor Kinase 5; C517898:GRK5 protein, human
keywords: Dementia; GRK5; Haplotype; Polymorphism