title: A Rare Cause of Lower Extremity Ulcers: Prolidase Deficiency.
abstract: Prolidase deficiency is an autosomal recessive disorder, which is associated with chronic skin ulcers, a characteristic facial appearance, mental retardation, and recurrent infections. This study describes 4 patients with recurrent leg ulcerations and abnormal facies who were first clinically suspected of prolidase deficiency and then biochemically confirmed. Two siblings and 2 other patients were admitted to our clinic at different times, and they had some common features such as chronic leg and foot ulcers recalcitrant to treatment, consanguineous parents, facial dysmorphism, mental retardation, and widespread telangiectasias. Physical examination and detection of low prolidase level in blood finally led us to the diagnose of ulcers secondary to prolidase deficiency. Prolidase deficiency is a rare genodermatosis and must be considered in the differential diagnosis of recurrent leg and foot ulcers that develop at an early age.
authors.affiliation: Gazi University, Ankara, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Adışen
authors.affiliation: Gazi University, Ankara, Turkey fbapur@yahoo.com.
authors.forename: Funda Bapur
authors.initials: FB
authors.lastname: Erduran
authors.affiliation: Gazi University, Ankara, Turkey.
authors.forename: Fatih Süheyl
authors.initials: FS
authors.lastname: Ezgü
authors.affiliation: Gazi University, Ankara, Turkey.
authors.forename: Çiğdem Seher
authors.initials: ÇS
authors.lastname: Kasapkara
authors.affiliation: Pavia University, Pavia, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Besio
authors.affiliation: Pavia University, Pavia, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Forlino
authors.affiliation: Gazi University, Ankara, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Gürer
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology* / Q000473:pathology; D008297:Male; D056732:Prolidase Deficiency / Q000150:complications*; D055815:Young Adult
keywords: extremity ulcers; prolidase deficiency; recalcitrant; telangiectasias