title: Investigation of Physicochemical Drug Properties to Prepare Fine Globular Granules Composed of Only Drug Substance in Fluidized Bed Rotor Granulation.
abstract: The effect of some drug properties (wettability and particle size distribution) on granule properties (mean particle size, particle size distribution, sphericity, and granule strength) were investigated in a high (>97%) drug-loading formulation using fluidized bed rotor granulation. Three drugs: acetaminophen (APAP); ibuprofen (IBU); and ethenzamide (ETZ) were used as model drugs based on their differences in wettability and particle size distribution. Granules with mean particle sizes of 100-200 µm and a narrow particle size distribution (PSD) could be prepared regardless of the drug used. IBU and ETZ granules showed a higher sphericity than APAP granules, while APAP and ETZ granules exhibited higher granule strength than IBU. The relationship between drug and granule properties suggested that the wettability and the PSD of the drugs were critical parameters affecting sphericity and granule strength, respectively. Furthermore, the dissolution profiles of granules prepared with poorly water-soluble drugs (IBU and ETZ) showed a rapid release (80% release in 20 min) because of the improved wettability with granulation. The present study demonstrated for the first time that fluidized bed rotor granulation can prepare high drug-loaded (>97%) globular granules with a mean particle size of less than 200 µm and the relationship between physicochemical drug properties and the properties of the granules obtained could be readily determined, indicating the potential for further application of this methodology to various drugs.
authors.affiliation: Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Mise
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Iwao
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Kimura
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Osugi
authors.forename: Shuji
authors.initials: S
authors.lastname: Noguchi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Itai
mesh_terms: D000082:Acetaminophen / Q000737:chemistry*; D002627:Chemistry, Physical; D007052:Ibuprofen / Q000737:chemistry*; D010316:Particle Size; D012457:Salicylamides / Q000737:chemistry*; D017155:Wettability
chemical_list: D012457:Salicylamides; D000082:Acetaminophen; C018935:ethenzamide; D007052:Ibuprofen