title: Prognostic Value of Ezrin in Various Cancers: A Systematic Review and Updated Meta-analysis.
abstract: More and more studies have investigated the effects of Ezrin expression level on the prognostic role in various tumors. However, the results remain controversial rather than conclusive. Here, we performed a systematic review and meta-analysis to evaluate the correlation of Ezrin expression with the prognosis in various tumors. the pooled hazard ratios (HR) with the corresponding 95% confidence intervals (95% CI) were calculated to evaluate the degree of the association. The overall results of fifty-five studies with 6675 patients showed that elevated Ezrin expression was associated with a worse prognosis in patients with cancers, with the pooled HRs of 1.86 (95% CI: 1.51-2.31, P < 0.001) for over survival (OS), 2.55 (95% CI: 2.14-3.05, P < 0.001) for disease-specific survival (DFS) and 2.02 (95% CI: 1.13-3.63, P = 0.018) for disease-specific survival (DSS)/metastasis-free survival (MFS) by the random, fixed and random effect model respectively. Similar results were also observed in the stratified analyses by tumor types, ethnicity background and sample source. This meta-analysis suggests that Ezrin may be a potential prognostic marker in cancer patients. High Ezrin is associated with a poor prognosis in a variety of solid tumors.
authors.affiliation: Department of Traumatology and Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Traumatology and Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Kuanhai
authors.initials: K
authors.lastname: Wei
authors.affiliation: Institute of Genetic Engineering, Southern Medical University, Guangzhou 510515, China.
authors.forename: Hailang
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Traumatology and Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Jin
authors.affiliation: Department of Traumatology and Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Traumatology and Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yu
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D018572:Disease-Free Survival; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000401:mortality; D011379:Prognosis; D000099149:Ezrin
chemical_list: D014408:Biomarkers, Tumor; D003598:Cytoskeletal Proteins; D000099149:Ezrin