title: Zwitterionic Cellulose Carbamate with Regioselective Substitution Pattern: A Coating Material Possessing Antimicrobial Activity.
abstract: A polyzwitterion is synthesized by regioselective functionalization of cellulose possessing a uniform charge distribution. The positively charged ammonium group is present at position 6, while the negative charge of carboxylate is located at positions 2 and 3 of the repeating unit. The molecular structure of the biopolymer derivative is proved by NMR spectroscopy. This cellulose-based zwitterion is applied to several support materials by spin-coating and characterized by means of atomic force microscope, contact angle measurements, ellipsometry, and X-ray photoelectron spectroscopy. The coatings possess antimicrobial activity depending on the support materials (glass, titanium, tissue culture poly(styrene)) as revealed by confocal laser scanning microscopy and live/dead staining.
authors.affiliation: Center of Excellence for Polysaccharide Research, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, Humboldtstraße 10, 07743, Jena, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Elschner
authors.affiliation: Materials Science, Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, Löbdergraben 32, 07743, Jena, Germany.|Jena Center of Microbial Communication (JCMC), Neugasse 23, 07743, Jena, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Lüdecke
authors.affiliation: Center of Excellence for Polysaccharide Research, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, Humboldtstraße 10, 07743, Jena, Germany.
authors.forename: Diana
authors.initials: D
authors.lastname: Kalden
authors.affiliation: Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Adolf-Reichwein-Straße 23, 07745, Jena, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Roth
authors.affiliation: Institute of Medical Microbiology, Jena University Hospital, Erlanger Allee 101, 07747, Jena, Germany.
authors.forename: Bettina
authors.initials: B
authors.lastname: Löffler
authors.affiliation: Materials Science, Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, Löbdergraben 32, 07743, Jena, Germany.|Jena Center of Microbial Communication (JCMC), Neugasse 23, 07743, Jena, Germany.
authors.forename: Klaus D
authors.initials: KD
authors.lastname: Jandt
authors.affiliation: Center of Excellence for Polysaccharide Research, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, Humboldtstraße 10, 07743, Jena, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Heinze
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects*; D002482:Cellulose / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D005898:Glass / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011137:Polystyrenes / Q000737:chemistry; D055672:Static Electricity; D013237:Stereoisomerism; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D011137:Polystyrenes; D002482:Cellulose; D014025:Titanium
keywords: E. coli; antimicrobial; cellulose; coating; zwitterion