title: A Population-based Study of Intensive Care Unit Admissions in Rheumatoid Arthritis.
abstract: OBJECTIVE
  We aimed to determine the incidence of and mortality after critical illness in rheumatoid arthritis (RA) compared with the general population, and to describe the risks for and characteristics of critical illness in patients with RA.
  
  
  METHODS
  We used population-based administrative data from the Data Repository at the Manitoba Centre for Health Policy from 1984 to 2010, and linked clinical data from an intensive care unit (ICU) database to identify all persons with RA in the province requiring ICU admission. We identified a population-based control group, matched by age, sex, socioeconomic status, and region of residence. The incidence of ICU admission, reasons for, and mortality after ICU admission were compared between populations using age- and sex-standardized rates, rate ratios, Cox proportional hazards models, and logistic regression models.
  
  
  RESULTS
  We identified 10,078 prevalent and 5560 incident cases of RA. After adjustment, the risk for ICU admission was higher for RA (HR 1.65, 95% CI 1.50-1.83) versus the matched general population. From 2000-2010, the annual incidence of ICU admission among prevalent patients was about 1% in RA, with a crude 10-year incidence of 8%. Compared with the general population admitted to ICU, 1 year after ICU admission, mortality was increased by 40% in RA. Cardiovascular disorders were the most common reason for ICU admission in RA.
  
  
  CONCLUSIONS
  Patients with RA have a higher risk for admission to the ICU than the general population and increased mortality 1 year after admission. Even with advances in management, RA remains a serious disease with significant morbidity.
authors.affiliation: From the Department of Internal Medicine, and Department of Community Health Sciences, and Manitoba Centre for Health Policy, and the IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.C.A. Peschken, MD, MSc, FRCPC, Associate Professor, Department of Internal Medicine, and Department of Community Health Sciences, University of Manitoba; C.A. Hitchon, MD, MSc, Department of Internal Medicine, University of Manitoba; A. Garland, MD, MA, Department of Internal Medicine, and Department of Community Health Sciences, and Manitoba Centre for Health Policy, University of Manitoba;C.N. Bernstein, MD, Department of Internal Medicine, and IBD Clinical and Research Centre, University of Manitoba; H. Chen, MSc, Manitoba Centre for Health Policy, University of Manitoba; R. Fransoo, PhD, Department of Community Health Sciences, and Manitoba Centre for Health Policy, University of Manitoba; R.A. Marrie, MD, PhD, Department of Internal Medicine, and Department of Community Health Sciences, University of Manitoba. christine.peschken@umanitoba.ca.
authors.forename: Christine A
authors.initials: CA
authors.lastname: Peschken
authors.affiliation: From the Department of Internal Medicine, and Department of Community Health Sciences, and Manitoba Centre for Health Policy, and the IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.C.A. Peschken, MD, MSc, FRCPC, Associate Professor, Department of Internal Medicine, and Department of Community Health Sciences, University of Manitoba; C.A. Hitchon, MD, MSc, Department of Internal Medicine, University of Manitoba; A. Garland, MD, MA, Department of Internal Medicine, and Department of Community Health Sciences, and Manitoba Centre for Health Policy, University of Manitoba;C.N. Bernstein, MD, Department of Internal Medicine, and IBD Clinical and Research Centre, University of Manitoba; H. Chen, MSc, Manitoba Centre for Health Policy, University of Manitoba; R. Fransoo, PhD, Department of Community Health Sciences, and Manitoba Centre for Health Policy, University of Manitoba; R.A. Marrie, MD, PhD, Department of Internal Medicine, and Department of Community Health Sciences, University of Manitoba.
authors.forename: Carol A
authors.initials: CA
authors.lastname: Hitchon
authors.affiliation: From the Department of Internal Medicine, and Department of Community Health Sciences, and Manitoba Centre for Health Policy, and the IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.C.A. Peschken, MD, MSc, FRCPC, Associate Professor, Department of Internal Medicine, and Department of Community Health Sciences, University of Manitoba; C.A. Hitchon, MD, MSc, Department of Internal Medicine, University of Manitoba; A. Garland, MD, MA, Department of Internal Medicine, and Department of Community Health Sciences, and Manitoba Centre for Health Policy, University of Manitoba;C.N. Bernstein, MD, Department of Internal Medicine, and IBD Clinical and Research Centre, University of Manitoba; H. Chen, MSc, Manitoba Centre for Health Policy, University of Manitoba; R. Fransoo, PhD, Department of Community Health Sciences, and Manitoba Centre for Health Policy, University of Manitoba; R.A. Marrie, MD, PhD, Department of Internal Medicine, and Department of Community Health Sciences, University of Manitoba.
authors.forename: Allan
authors.initials: A
authors.lastname: Garland
authors.affiliation: From the Department of Internal Medicine, and Department of Community Health Sciences, and Manitoba Centre for Health Policy, and the IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.C.A. Peschken, MD, MSc, FRCPC, Associate Professor, Department of Internal Medicine, and Department of Community Health Sciences, University of Manitoba; C.A. Hitchon, MD, MSc, Department of Internal Medicine, University of Manitoba; A. Garland, MD, MA, Department of Internal Medicine, and Department of Community Health Sciences, and Manitoba Centre for Health Policy, University of Manitoba;C.N. Bernstein, MD, Department of Internal Medicine, and IBD Clinical and Research Centre, University of Manitoba; H. Chen, MSc, Manitoba Centre for Health Policy, University of Manitoba; R. Fransoo, PhD, Department of Community Health Sciences, and Manitoba Centre for Health Policy, University of Manitoba; R.A. Marrie, MD, PhD, Department of Internal Medicine, and Department of Community Health Sciences, University of Manitoba.
authors.forename: Charles N
authors.initials: CN
authors.lastname: Bernstein
authors.affiliation: From the Department of Internal Medicine, and Department of Community Health Sciences, and Manitoba Centre for Health Policy, and the IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.C.A. Peschken, MD, MSc, FRCPC, Associate Professor, Department of Internal Medicine, and Department of Community Health Sciences, University of Manitoba; C.A. Hitchon, MD, MSc, Department of Internal Medicine, University of Manitoba; A. Garland, MD, MA, Department of Internal Medicine, and Department of Community Health Sciences, and Manitoba Centre for Health Policy, University of Manitoba;C.N. Bernstein, MD, Department of Internal Medicine, and IBD Clinical and Research Centre, University of Manitoba; H. Chen, MSc, Manitoba Centre for Health Policy, University of Manitoba; R. Fransoo, PhD, Department of Community Health Sciences, and Manitoba Centre for Health Policy, University of Manitoba; R.A. Marrie, MD, PhD, Department of Internal Medicine, and Department of Community Health Sciences, University of Manitoba.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: From the Department of Internal Medicine, and Department of Community Health Sciences, and Manitoba Centre for Health Policy, and the IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.C.A. Peschken, MD, MSc, FRCPC, Associate Professor, Department of Internal Medicine, and Department of Community Health Sciences, University of Manitoba; C.A. Hitchon, MD, MSc, Department of Internal Medicine, University of Manitoba; A. Garland, MD, MA, Department of Internal Medicine, and Department of Community Health Sciences, and Manitoba Centre for Health Policy, University of Manitoba;C.N. Bernstein, MD, Department of Internal Medicine, and IBD Clinical and Research Centre, University of Manitoba; H. Chen, MSc, Manitoba Centre for Health Policy, University of Manitoba; R. Fransoo, PhD, Department of Community Health Sciences, and Manitoba Centre for Health Policy, University of Manitoba; R.A. Marrie, MD, PhD, Department of Internal Medicine, and Department of Community Health Sciences, University of Manitoba.
authors.forename: Randy
authors.initials: R
authors.lastname: Fransoo
authors.affiliation: From the Department of Internal Medicine, and Department of Community Health Sciences, and Manitoba Centre for Health Policy, and the IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.C.A. Peschken, MD, MSc, FRCPC, Associate Professor, Department of Internal Medicine, and Department of Community Health Sciences, University of Manitoba; C.A. Hitchon, MD, MSc, Department of Internal Medicine, University of Manitoba; A. Garland, MD, MA, Department of Internal Medicine, and Department of Community Health Sciences, and Manitoba Centre for Health Policy, University of Manitoba;C.N. Bernstein, MD, Department of Internal Medicine, and IBD Clinical and Research Centre, University of Manitoba; H. Chen, MSc, Manitoba Centre for Health Policy, University of Manitoba; R. Fransoo, PhD, Department of Community Health Sciences, and Manitoba Centre for Health Policy, University of Manitoba; R.A. Marrie, MD, PhD, Department of Internal Medicine, and Department of Community Health Sciences, University of Manitoba.
authors.forename: Ruth Ann
authors.initials: RA
authors.lastname: Marrie
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D016022:Case-Control Studies; D002423:Cause of Death; D016638:Critical Illness / Q000453:epidemiology*; D016208:Databases, Factual; D005260:Female; D017052:Hospital Mortality / Q000639:trends*; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D053208:Kaplan-Meier Estimate; D008297:Male; D008350:Manitoba; D008875:Middle Aged; D015999:Multivariate Analysis; D010343:Patient Admission / Q000706:statistics & numerical data*; D016016:Proportional Hazards Models; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis
keywords: ADMINISTRATIVE DATA; CRITICAL ILLNESS; INCIDENCE; RHEUMATOID ARTHRITIS