title: The Potential of Intralesional Rose Bengal to Stimulate T-Cell Mediated Anti-Tumor Responses.
abstract: Rose Bengal (RB) is a red synthetic dye that was initially used in the garment industry and has been used safely for decades as a corneal stain by ophthalmologists. Antineoplastic properties of RB have also been observed, though the mechanism of action remained to be elucidated. Recently, interest in RB as a therapeutic cancer treatment has increased due to significant anti-tumor responses with direct tumor injection in human clinical trials for metastatic melanoma. In these patients, there has been the implication that RB may mount a T-cell mediated anti-tumor response and impart antigen-specific responses in distant bystander lesions. This article serves to evaluate the potential of intralesional rose bengal to stimulate T-cell mediated anti-tumor responses in in-vitro, pre-clinical, and clinical studies.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Illinois at Chicago, Chicago Illinois, USA ; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago Illinois, USA.
authors.forename: Ajay V
authors.initials: AV
authors.lastname: Maker
authors.affiliation: Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago Illinois, USA.
authors.forename: Bellur
authors.initials: B
authors.lastname: Prabhakar
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Illinois at Chicago, Chicago Illinois, USA.
authors.forename: Krunal
authors.initials: K
authors.lastname: Pardiwala
keywords: PV10; Rose bengal; T-cell mediated anti-tumor responses; metastatic melanoma