title: Novel Ultrasound Joint Selection Methods Using a Reduced Joint Number Demonstrate Inflammatory Improvement when Compared to Existing Methods and Disease Activity Score at 28 Joints.
abstract: OBJECTIVE
  A pilot study testing novel ultrasound (US) joint-selection methods in rheumatoid arthritis.
  
  
  METHODS
  Responsiveness of novel [individualized US (IUS) and individualized composite US (ICUS)] methods were compared with existing US methods and the Disease Activity Score at 28 joints (DAS28) for 12 patients followed for 3 months. IUS selected up to 7 and 12 most ultrasonographically inflamed joints, while ICUS additionally incorporated clinically symptomatic joints.
  
  
  RESULTS
  The existing, IUS, and ICUS methods' standardized response means were -0.39, -1.08, and -1.11, respectively, for 7 joints; -0.49, -1.00, and -1.16, respectively, for 12 joints; and -0.94 for DAS28.
  
  
  CONCLUSIONS
  Novel methods effectively demonstrate inflammatory improvement when compared with existing methods and DAS28.
authors.affiliation: From the Department of Rheumatology and Immunology, Singapore General Hospital; Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Assistance Publique - Hôpitaux de Paris (APHP), Hôpital Ambroise Paré, Boulogne-Billancourt; Institut national de la santé et de la recherche médicale (INSERM) U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.Y.K. Tan, MBBS, MMED, MRCP, Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J.C. Allen Jr, PhD, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; W.K. Lye, MSc, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Musculoskeletal Biomedical Research Unit; M.A. D'Agostino, MD, PhD, Professor of Rheumatology, APHP, Department of Rheumatology, Hôpital Ambroise Paré, and INSERM U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines; L.C. Chew, BMED, SCI, BMBS, MRCP, FAMS, Senior Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J. Thumboo, MBBS, MMED, MRCP, FAMS, FRCP, Vice Chair for Research
authors.forename: York Kiat
authors.initials: YK
authors.lastname: Tan
authors.affiliation: From the Department of Rheumatology and Immunology, Singapore General Hospital; Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Assistance Publique - Hôpitaux de Paris (APHP), Hôpital Ambroise Paré, Boulogne-Billancourt; Institut national de la santé et de la recherche médicale (INSERM) U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.Y.K. Tan, MBBS, MMED, MRCP, Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J.C. Allen Jr, PhD, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; W.K. Lye, MSc, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Musculoskeletal Biomedical Research Unit; M.A. D'Agostino, MD, PhD, Professor of Rheumatology, APHP, Department of Rheumatology, Hôpital Ambroise Paré, and INSERM U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines; L.C. Chew, BMED, SCI, BMBS, MRCP, FAMS, Senior Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J. Thumboo, MBBS, MMED, MRCP, FAMS, FRCP, Vice Chair for Research
authors.forename: John C
authors.initials: JC
authors.lastname: Allen
authors.affiliation: From the Department of Rheumatology and Immunology, Singapore General Hospital; Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Assistance Publique - Hôpitaux de Paris (APHP), Hôpital Ambroise Paré, Boulogne-Billancourt; Institut national de la santé et de la recherche médicale (INSERM) U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.Y.K. Tan, MBBS, MMED, MRCP, Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J.C. Allen Jr, PhD, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; W.K. Lye, MSc, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Musculoskeletal Biomedical Research Unit; M.A. D'Agostino, MD, PhD, Professor of Rheumatology, APHP, Department of Rheumatology, Hôpital Ambroise Paré, and INSERM U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines; L.C. Chew, BMED, SCI, BMBS, MRCP, FAMS, Senior Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J. Thumboo, MBBS, MMED, MRCP, FAMS, FRCP, Vice Chair for Research
authors.forename: Weng Kit
authors.initials: WK
authors.lastname: Lye
authors.affiliation: From the Department of Rheumatology and Immunology, Singapore General Hospital; Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Assistance Publique - Hôpitaux de Paris (APHP), Hôpital Ambroise Paré, Boulogne-Billancourt; Institut national de la santé et de la recherche médicale (INSERM) U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.Y.K. Tan, MBBS, MMED, MRCP, Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J.C. Allen Jr, PhD, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; W.K. Lye, MSc, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Musculoskeletal Biomedical Research Unit; M.A. D'Agostino, MD, PhD, Professor of Rheumatology, APHP, Department of Rheumatology, Hôpital Ambroise Paré, and INSERM U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines; L.C. Chew, BMED, SCI, BMBS, MRCP, FAMS, Senior Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J. Thumboo, MBBS, MMED, MRCP, FAMS, FRCP, Vice Chair for Research
authors.forename: Philip G
authors.initials: PG
authors.lastname: Conaghan
authors.affiliation: From the Department of Rheumatology and Immunology, Singapore General Hospital; Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Assistance Publique - Hôpitaux de Paris (APHP), Hôpital Ambroise Paré, Boulogne-Billancourt; Institut national de la santé et de la recherche médicale (INSERM) U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.Y.K. Tan, MBBS, MMED, MRCP, Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J.C. Allen Jr, PhD, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; W.K. Lye, MSc, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Musculoskeletal Biomedical Research Unit; M.A. D'Agostino, MD, PhD, Professor of Rheumatology, APHP, Department of Rheumatology, Hôpital Ambroise Paré, and INSERM U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines; L.C. Chew, BMED, SCI, BMBS, MRCP, FAMS, Senior Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J. Thumboo, MBBS, MMED, MRCP, FAMS, FRCP, Vice Chair for Research
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: D'Agostino
authors.affiliation: From the Department of Rheumatology and Immunology, Singapore General Hospital; Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Assistance Publique - Hôpitaux de Paris (APHP), Hôpital Ambroise Paré, Boulogne-Billancourt; Institut national de la santé et de la recherche médicale (INSERM) U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.Y.K. Tan, MBBS, MMED, MRCP, Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J.C. Allen Jr, PhD, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; W.K. Lye, MSc, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Musculoskeletal Biomedical Research Unit; M.A. D'Agostino, MD, PhD, Professor of Rheumatology, APHP, Department of Rheumatology, Hôpital Ambroise Paré, and INSERM U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines; L.C. Chew, BMED, SCI, BMBS, MRCP, FAMS, Senior Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J. Thumboo, MBBS, MMED, MRCP, FAMS, FRCP, Vice Chair for Research
authors.forename: Li-Ching
authors.initials: LC
authors.lastname: Chew
authors.affiliation: From the Department of Rheumatology and Immunology, Singapore General Hospital; Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Assistance Publique - Hôpitaux de Paris (APHP), Hôpital Ambroise Paré, Boulogne-Billancourt; Institut national de la santé et de la recherche médicale (INSERM) U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.Y.K. Tan, MBBS, MMED, MRCP, Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J.C. Allen Jr, PhD, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; W.K. Lye, MSc, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Musculoskeletal Biomedical Research Unit; M.A. D'Agostino, MD, PhD, Professor of Rheumatology, APHP, Department of Rheumatology, Hôpital Ambroise Paré, and INSERM U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines; L.C. Chew, BMED, SCI, BMBS, MRCP, FAMS, Senior Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J. Thumboo, MBBS, MMED, MRCP, FAMS, FRCP, Vice Chair for Research
authors.forename: Julian
authors.initials: J
authors.lastname: Thumboo
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000008:administration & dosage; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology*; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006769:Hospitals, General; D006801:Humans; D007596:Joints / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D018579:Patient Selection; D010865:Pilot Projects; D016059:Range of Motion, Articular / Q000502:physiology; D018570:Risk Assessment; D012720:Severity of Illness Index; D012846:Singapore; D013585:Synovitis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D018608:Ultrasonography, Doppler / Q000379:methods*
chemical_list: D018501:Antirheumatic Agents
keywords: RHEUMATOID ARTHRITIS; SYNOVITIS; ULTRASOUND