title: Renal angiomyolipoma with epithelial cysts: a rare entity and review of literature.
abstract: Renal angiomyolipoma (AML) with epithelial cysts (AMLEC) is a comparatively rare benign renal tumor that is recently recognized as a distinct entity and there are relatively few reported cases in the English-language literature. To date 19 cases of AMLEC have been reported in 2 case series and a few case reports. AMLEC has been described as a cystic variant of AML. Herein we reported an AMLEC in a 25-year-old female patient, and to the best of our knowledge this is the first case report of AMLEC in Chinese. She was incidentally found to have a kidney-occupying lesion during a routine medical examination for 1 month. CT examination demonstrated a multilocular cystic lesions arising from right-kidney lower pole. The patient underwent the partial nephrectomy. Histological examination of the tumor was composed of epithelial cysts, compact subepithelial mullerian-like stroma and muscle-predominant AML. Immunohistochemically, epithelial cysts were positive for CK but negative for ER, PR, CD10 and HMB-45; the subepithelial stroma and muscle-predominant AML were positive for ER, PR and HMB-45; the subepithelial stroma was negative for SMA, but muscle-predominant AML was positive for SMA. The final histopathological diagnosis was AMLEC.
authors.affiliation: Department of Pathology, Shaoxing People's Hospital Shaoxing, Zhejiang Province, P. R. China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wei
authors.affiliation: Department of Pathology, Affiliated Hospital of Jining Medical University Jining, Shandong Province, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Pathology, Zhoushan Hospital Zhoushan, Zhejiang Province, P. R. China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Wen
authors.affiliation: Department of Pathology, Affiliated Hospital of Jining Medical University Jining, Shandong Province, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Pathology, Affiliated Hospital of Jining Medical University Jining, Shandong Province, P. R. China.
authors.forename: Renya
authors.initials: R
authors.lastname: Zhang
mesh_terms: D000328:Adult; D018207:Angiomyolipoma / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D003560:Cysts / Q000473:pathology*; D004848:Epithelium / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Kidney; angiomyolipoma with epithelial cysts; mixed epithelial and stromal tumor