title: Comparative genomic hybridization analysis of invasive ductal breast carcinomas in the Chinese population.
abstract: Breast cancer is the most common malignancy in Chinese women. The aim of the present study was to investigate the genetic alterations that occur in breast cancer cells in Chinese women. Comparative genomic hybridization (CGH) analysis was performed on 34 tumors obtained from patients with primary invasive ductal breast carcinoma (IDC). Recurrent genetic alterations in breast cancer include gains on chromosomes 1q (59%), 16p (50%), 17q (44%), 8q (38%), 11q (32%), 20q (32%), 1p (24%), 20p (24%), 19q (21%) and 19p (18%). Losses are common on chromosomes 6q (15%), 8p (12%), 18 (12%), 4q (9%), X (9%) and 17p (9%). In the present study, high-level amplifications were observed on chromosomes 1q32, 8p, 11q13, 17q and 20q. Overall, the chromosomal DNA gains observed were consistent with the changes reported in Caucasian populations. However, the incidence of chromosomal DNA loss was lower in the present study compared with the incidence reported in the literature. The present results demonstrate the pattern of chromosomal imbalances in the invasive ductal breast carcinomas of Chinese females.
authors.affiliation: Department of Oncology, Beijing Army General Hospital, Beijing 100700, P.R. China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Beijing Army General Hospital, Beijing 100700, P.R. China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.affiliation: National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China.
authors.forename: Mingrong
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Oncology, Beijing Army General Hospital, Beijing 100700, P.R. China.
authors.forename: Zhonghe
authors.initials: Z
authors.lastname: Yu
keywords: comparative genomic hybridization; copy number changes; ductal breast carcinomas