title: Sinonasal Malignancies of Anterior Skull Base: Histology-driven Treatment Strategies.
abstract: The advances in endoscopy have revolutionized the management of sinonasal and skull base lesions. Many complex cancers that traditionally required open approaches are now amenable to purely endoscopic endonasal resection, providing less invasive surgery with lower morbidity but with comparable oncologic outcomes in terms of survival rates. This article discusses the current evidence for the multimodal management of sinonasal and anterior skull base cancers focusing on the different treatment protocols driven by histologic subtypes.
authors.affiliation: Unit of Otorhinolaryngology, Department of Biotechnology and Life Sciences (DBSV), Ospedale di Circolo e Fondazione Macchi, University of Insubria, via Guicciardini 9, Varese 21100, Italy; Department of Biotechnology and Life Sciences (DBSV), Head and Neck Surgery & Forensic Dissection Research Center (HNS&FDRc), University of Insubria, via Guicciardini 9, Varese 21100, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Castelnuovo
authors.affiliation: Unit of Otorhinolaryngology, Department of Biotechnology and Life Sciences (DBSV), Ospedale di Circolo e Fondazione Macchi, University of Insubria, via Guicciardini 9, Varese 21100, Italy; Department of Biotechnology and Life Sciences (DBSV), Head and Neck Surgery & Forensic Dissection Research Center (HNS&FDRc), University of Insubria, via Guicciardini 9, Varese 21100, Italy. Electronic address: tzmario@inwind.it.
authors.forename: Mario
authors.initials: M
authors.lastname: Turri-Zanoni
authors.affiliation: Unit of Otorhinolaryngology, Department of Biotechnology and Life Sciences (DBSV), Ospedale di Circolo e Fondazione Macchi, University of Insubria, via Guicciardini 9, Varese 21100, Italy; Department of Biotechnology and Life Sciences (DBSV), Head and Neck Surgery & Forensic Dissection Research Center (HNS&FDRc), University of Insubria, via Guicciardini 9, Varese 21100, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Battaglia
authors.affiliation: Division of Radiation Oncology, University of Insubria, viale Borri 57, Varese 21100, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Antognoni
authors.affiliation: Head and Neck Cancer Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, Milano 20133, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bossi
authors.affiliation: Department of Biotechnology and Life Sciences (DBSV), Head and Neck Surgery & Forensic Dissection Research Center (HNS&FDRc), University of Insubria, via Guicciardini 9, Varese 21100, Italy; Unit of Neurosurgery, University of Insubria, via Guicciardini 9, Varese 21100, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Locatelli
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery; D002277:Carcinoma / Q000601:surgery; D003528:Carcinoma, Adenoid Cystic / Q000601:surgery; D018278:Carcinoma, Neuroendocrine / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D019468:Disease Management; D004724:Endoscopy / Q000379:methods*; D018304:Esthesioneuroblastoma, Olfactory / Q000601:surgery; D006393:Hemangiopericytoma / Q000601:surgery; D006801:Humans; D008444:Maxillary Sinus Neoplasms / Q000601:surgery; D009666:Nose / Q000601:surgery*; D011362:Professional Corporations; D019291:Skull Base / Q000601:surgery*; D019292:Skull Base Neoplasms / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate
keywords: Adenocarcinoma; Chemotherapy; Endoscopic endonasal; Mucosal melanoma; Olfactory neuroblastoma; Paranasal sinuses; Radiotherapy; Skull base cancer