title: Diabetes in the post-GWAS era.
abstract: Large sample sizes, high-resolution arrays and comprehensive imputation are pushing genetic fine-mapping of complex trait loci to its limits without, in most cases, pinpointing a unique variant-gene combination. Superimposing these results on sophisticated maps of functional chromatin elements promises to break this logjam, as a new study of type 2 diabetes compellingly demonstrates.
authors.affiliation: The Endocrine Genetics Laboratory, Child Health and Human Development Program and Department of Pediatrics, McGill University Health Centre Research Institute, Montreal, Quebec, Canada.
authors.forename: Constantin
authors.initials: C
authors.lastname: Polychronakos
authors.affiliation: The Endocrine Genetics Laboratory, Child Health and Human Development Program and Department of Pediatrics, McGill University Health Centre Research Institute, Montreal, Quebec, Canada.
authors.forename: Maha
authors.initials: M
authors.lastname: Alriyami
mesh_terms: D002874:Chromosome Mapping; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D051542:Hepatocyte Nuclear Factor 3-beta / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044123:Receptor, Melatonin, MT2 / Q000235:genetics*
chemical_list: D044123:Receptor, Melatonin, MT2; D051542:Hepatocyte Nuclear Factor 3-beta