title: Current Research on Antiepileptic Compounds.
abstract: Epilepsy affects about 1% of the world's population. Due to the fact all antiepileptic drugs (AEDs) have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for the development of more effective and safer AEDs. Based on our research work on antiepileptic compounds and other references in recent years, this review covers the reported work on antiepileptic compounds which are classified according to their structures. This review summarized 244 significant anticonvulsant compounds which are classified by functional groups according to the animal model data, although there are some limitations in the data. This review highlights the properties of new compounds endowed with promising antiepileptic properties, which may be proven to be more effective and selective, and possibly free of unwanted side effects. The reviewed compounds represent an interesting possibility to overcome refractory seizures and to reduce the percentage of patients with a poor response to drug therapy.
authors.affiliation: Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao 028000, China. weichengxi1224@163.com.
authors.forename: Cheng-Xi
authors.initials: CX
authors.lastname: Wei
authors.affiliation: Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao 028000, China. xiaopang1224@126.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Bian
authors.affiliation: Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao 028000, China. gongguohua0211@163.com.|Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia, China. gongguohua0211@163.com.
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Gong
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D055808:Drug Discovery; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D012106:Research; D013329:Structure-Activity Relationship
chemical_list: D000927:Anticonvulsants
keywords: antiepileptic compounds; epilepsy; structure activity relationship