title: Soy Protein Alleviates Hypertension and Fish Oil Improves Diastolic Heart Function in the Han:SPRD-Cy Rat Model of Cystic Kidney Disease.
abstract: Abnormalities in cardiac structure and function are very common among people with chronic kidney disease, in whom cardiovascular disease is the major cause of death. Dietary soy protein and fish oil reduce kidney disease progression in the Han:SPRD-Cy model of cystic renal disease. However, the effects of these dietary interventions in preventing alterations in cardiac structure and function due to kidney disease (reno-cardiac syndrome) in a cystic kidney disease model are not known. Therefore, weanling Han:SPRD-Cy diseased (Cy/+) and normal (+/+) rats were given diets containing either casein or soy protein, and either soy or fish oil in a three-way design for 8 weeks. Diseased rats had larger hearts, augmented left ventricular mass, and higher systolic and mean arterial blood pressure compared to the normal rats. Assessment of cardiac function using two-dimensional guided M-mode and pulse-wave Doppler echocardiography revealed that isovolumic relaxation time was prolonged in the diseased compared to normal rats, reflecting a diastolic heart dysfunction, and fish oil prevented this elevation. Soy protein resulted in a small improvement in systolic and mean arterial pressure but did not improve diastolic heart function, while fish oil prevented diastolic heart dysfunction in this model of cystic kidney disease.
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, W573 Duff Roblin Building, Winnipeg, MB, R3T 2N2, Canada.|Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB, Canada.|Richardson Centre for Functional Foods and Nutraceuticals, Winnipeg, MB, Canada.
authors.forename: Naser H M
authors.initials: NH
authors.lastname: Ibrahim
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, W573 Duff Roblin Building, Winnipeg, MB, R3T 2N2, Canada.|Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB, Canada.|Richardson Centre for Functional Foods and Nutraceuticals, Winnipeg, MB, Canada.|Heart Failure Research Laboratory, Department of Physiology, Canadian Centre for Agri-Food Research in Health and Medicine, St Boniface Hospital Research Centre, University of Manitoba, 351 Tache Avenue, Winnipeg, MB, R2H 2A6, Canada.|Agriculture and Agri-Food Canada, Winnipeg, MB, Canada.
authors.forename: Sijo J
authors.initials: SJ
authors.lastname: Thandapilly
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, W573 Duff Roblin Building, Winnipeg, MB, R3T 2N2, Canada.
authors.forename: Yong
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB, Canada. tnetticadan@sbrc.ca.|Heart Failure Research Laboratory, Department of Physiology, Canadian Centre for Agri-Food Research in Health and Medicine, St Boniface Hospital Research Centre, University of Manitoba, 351 Tache Avenue, Winnipeg, MB, R2H 2A6, Canada. tnetticadan@sbrc.ca.|Agriculture and Agri-Food Canada, Winnipeg, MB, Canada. tnetticadan@sbrc.ca.
authors.forename: Thomas
authors.initials: T
authors.lastname: Netticadan
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, W573 Duff Roblin Building, Winnipeg, MB, R3T 2N2, Canada. harold.aukema@umanitoba.ca.|Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB, Canada. harold.aukema@umanitoba.ca.|Richardson Centre for Functional Foods and Nutraceuticals, Winnipeg, MB, Canada. harold.aukema@umanitoba.ca.
authors.forename: Harold
authors.initials: H
authors.lastname: Aukema
mesh_terms: D000818:Animals; D001794:Blood Pressure; D019587:Dietary Supplements / Q000032:analysis; D005395:Fish Oils / Q000627:therapeutic use*; D006321:Heart / Q000503:physiopathology*; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D007668:Kidney / Q000503:physiopathology*; D052177:Kidney Diseases, Cystic / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D051381:Rats; D030262:Soybean Proteins / Q000627:therapeutic use*
chemical_list: D005395:Fish Oils; D030262:Soybean Proteins
keywords: Blood pressure; Cardiovascular disease; Cystic kidney disease; Echocardiography; Fish oil; Isovolumic relaxation time; Reno-cardiac syndrome; Soy protein