title: Chemo-enzymatic Baeyer-Villiger oxidation of 4-methylcyclohexanone via kinetic resolution of racemic carboxylic acids: direct access to enantioenriched lactone.
abstract: A new method for the asymmetric chemo-enzymatic Baeyer-Villiger oxidation of prochiral 4-methylcyclohexanone to (R)-4-methylcaprolactone in the presence of (±)-4-methyloctanoic acid, Candida Antarctica lipase B and 30% aq. H2O2 has been developed. A mechanism for the asymmetric induction based on kinetic resolution of racemic carboxylic acids is proposed.
authors.affiliation: Silesian University of Technology, Department of Chemical Organic Technology and Petrochemistry, Krzywoustego 4, 44-100 Gliwice, Poland. anna.chrobok@polsl.pl.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Drożdż
authors.affiliation: Silesian University of Technology, Department of Chemical Organic Technology and Petrochemistry, Krzywoustego 4, 44-100 Gliwice, Poland. anna.chrobok@polsl.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Chrobok
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D003512:Cyclohexanones / Q000737:chemistry*; D007700:Kinetics; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D002264:Carboxylic Acids; D003512:Cyclohexanones