title: Cutaneous Pseudallescheria boydii/Scedosporium apiospermum Complex (Molecular type: Scedosporium apiospermum [Clade 4]) Infection: A Case Report and Literature Review of Cases from Japan.
abstract: We report a case of subcutaneous Pseudallescheria boydii/Scedosporium apiospermum complex infection occurring in a 77-year-old Japanese female farmer suffering from interstitial pneumonia. Seven months prior to the current presentation, she noticed nodes on her right forearm after pulling up weeds, and the nodes grew larger. Two soft dome-shaped, protruded nodes ( 15 mm and 30 mm in size ) had fused together on the extensor surface of the right forearm. Yellowish-white, rice-grain-sized pustules clustered on the surface. Histopathological examination of the skin specimen showed large and small abscesses surrounded by epithelioid granuloma; separate branching hyphae within the granulation tissue were stained with PAS. No grains were observed. Fungal culture yielded fast-growing, grayish-white, fluffy colonies which were identified as Scedosporium apiospermum (Clade 4) using sequence analysis of the β-tubulin gene. We also reviewed 28 previously reported Japanese cases of P. boydii or S. apiospermum infection presenting with skin manifestations.
authors.affiliation: Department of Dermatology, Juntendo University, Shizuoka Hospital.
authors.forename: Satoko
authors.initials: S
authors.lastname: Ishii
authors.forename: Midori
authors.initials: M
authors.lastname: Hiruma
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugita
authors.forename: Koichi
authors.initials: K
authors.lastname: Makimura
authors.forename: Masataro
authors.initials: M
authors.lastname: Hiruma
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiike
mesh_terms: D000284:Administration, Oral; D000368:Aged; D044466:Asian People; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects; D003881:Dermatomycoses / Q000175:diagnosis / Q000209:etiology / Q000382:microbiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000150:complications / Q000188:drug therapy; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D011541:Pseudallescheria / Q000302:isolation & purification*; D021681:Scedosporium / Q000302:isolation & purification*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine