title: Beneficial effects of aminoguanidine on radiotherapy-induced kidney and testis injury.
abstract: This experimental study was designed to investigate both protective and therapeutic effects of aminoguanidine (AG), on radiotherapy (RT)-induced oxidative stress in kidney and testis. Forty rats were divided into five groups equally as follows: (i) control, (ii) RT, (iii) AG, (iv) AG+RT and (v) RT+AG group. Histopathological findings and biochemical evaluations, including tissue malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione (GSH), total oxidant status (TOS), total antioxidant capacity, oxidative stress index (OSI), blood urea nitrogen (BUN), serum creatinine (Cr) and testosterone levels, were determined. MDA, TOS and OSI were significantly higher in RT-treated groups, whereas SOD, CAT, GPX and GSH were significantly lower in these groups when compared with the control rats in the kidney and testis tissue. AG treatment significantly decreased MDA, TOS and OSI levels and increased SOD, CAT, GPX and GSH levels, when compared to the RT-treated groups in both kidney and testis tissue. BUN and Cr levels did not change among the groups, whereas testosterone levels were found as reduced in the RT-treated rats. AG treatment significantly augmented these hazardous effects of RT on testis tissue. According to our results, AG has beneficial effects against RT-induced kidney and testis injury.
authors.affiliation: Department of Radiation Oncology, Medical Faculty, Inonu University, Malatya, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Ekici
authors.affiliation: Department of Radiation Oncology, Medical Faculty, Inonu University, Malatya, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Temelli
authors.affiliation: Department of Pharmacology, Medical Faculty, Inonu University, Malatya, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Parlakpinar
authors.affiliation: Department of Pathology, Medical Faculty, Inonu University, Malatya, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Samdanci
authors.affiliation: Department of Physiology, Medical Faculty, Inonu University, Malatya, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Polat
authors.affiliation: Department of Urology, Medical Faculty, Inonu University, Malatya, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Beytur
authors.affiliation: Department of Physiology, Medical Faculty, Inonu University, Malatya, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Tanbek
authors.affiliation: Department of Medical Biology and Genetics, Medical Faculty, Inonu University, Malatya, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Ekici
authors.affiliation: Department of Medical Oncology, Medical Faculty, Inonu University, Malatya, Turkey.
authors.forename: I H
authors.initials: IH
authors.lastname: Dursun
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013737:Testis / Q000187:drug effects* / Q000378:metabolism
chemical_list: D006146:Guanidines; D020011:Protective Agents; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; C004479:pimagedine
keywords: aminoguanidine; kidney; oxidative stress; radiotherapy; testis