title: Hepatic and Splenic Acoustic Radiation Force Impulse Shear Wave Velocity Elastography in Children with Liver Disease Associated with Cystic Fibrosis.
abstract: Liver disease associated with cystic fibrosis (CFLD) is the second cause of mortality in these patients. The diagnosis is difficult because none of the available tests are specific enough. Noninvasive elastographic techniques have been proven to be useful to diagnose hepatic fibrosis. Acoustic radiation force impulse (ARFI) imaging is an elastography imaging system. The purpose of the work was to study the utility of liver and spleen ARFI Imaging in the detection of CFLD. Method. 72 patients with cystic fibrosis (CF) were studied and received ARFI imaging in the liver and in the spleen. SWV values were compared with the values of 60 healthy controls. Results. Comparing the SWV values of CFLD with the control healthy group, values in the right lobe were higher in patients with CFLD. We found a SWV RHL cut-off value to detect CFLD of 1.27 m/s with a sensitivity of 56.5% and a specificity of 90.5%. CF patients were found to have higher SWC spleen values than the control group. Conclusions. ARFI shear wave elastography in the right hepatic lobe is a noninvasive technique useful to detect CFLD in our sample of patients. Splenic SWV values are higher in CF patients, without any clinical consequence.
authors.affiliation: Hospital Universitario Infantil Niño Jesús, 28009 Madrid, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Cañas
authors.affiliation: Universidad Nacional de Educación a Distancia (UNED), 28040 Madrid, Spain.
authors.forename: Araceli
authors.initials: A
authors.lastname: Maciá
authors.affiliation: Hospital Universitario Infantil Niño Jesús, 28009 Madrid, Spain.
authors.forename: Rosa Ana
authors.initials: RA
authors.lastname: Muñoz-Codoceo
authors.affiliation: Hospital Universitario Puerta de Hierro, 28222 Majadahonda, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Fontanilla
authors.affiliation: Hospital Universitario Infantil Niño Jesús, 28009 Madrid, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: González-Rios
authors.affiliation: Hospital Universitario Puerta de Hierro, 28222 Majadahonda, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Miralles
authors.affiliation: Hospital Universitario Infantil Niño Jesús, 28009 Madrid, Spain.
authors.forename: Gloria
authors.initials: G
authors.lastname: Gómez-Mardones
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging / Q000473:pathology*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013154:Spleen / Q000000981:diagnostic imaging / Q000473:pathology*