title: Concomitant gain of 1q21 and MYC translocation define a poor prognostic subgroup of hyperdiploid multiple myeloma.
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Germany Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA NWeinhold@uams.edu.
authors.forename: Niels
authors.initials: N
authors.lastname: Weinhold
authors.affiliation: Institute of Human Genetics, University of Heidelberg, Germany.
authors.forename: Desiree
authors.initials: D
authors.lastname: Kirn
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Seckinger
authors.affiliation: Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hielscher
authors.affiliation: Institute of Human Genetics, University of Heidelberg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Granzow
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Germany.
authors.forename: Uta
authors.initials: U
authors.lastname: Bertsch
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Germany.
authors.forename: Gerlinde
authors.initials: G
authors.lastname: Egerer
authors.affiliation: Department of Hematology and Oncology, Asklepios Klinik Altona, Hamburg, Germany.
authors.forename: Hans
authors.initials: H
authors.lastname: Salwender
authors.affiliation: Department of Medicine III, Charité Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Igor W
authors.initials: IW
authors.lastname: Blau
authors.affiliation: Department of Hematology, Oncology and Immunology, University of Tübingen, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Weisel
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Hillengass
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Germany.
authors.forename: Marc S
authors.initials: MS
authors.lastname: Raab
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Germany National Center for Tumor Diseases, Heidelberg, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Hose
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Germany National Center for Tumor Diseases, Heidelberg, Germany.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Goldschmidt
authors.affiliation: Institute of Human Genetics, University of Heidelberg, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Jauch
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002878:Chromosomes, Human, Pair 1 / Q000737:chemistry*; D017353:Gene Deletion; D015870:Gene Expression; D056426:Genetic Loci; D006801:Humans; D009101:Multiple Myeloma / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality; D016254:Mutagenesis, Insertional; D009367:Neoplasm Staging; D010950:Plasma Cells / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D011003:Ploidies; D011379:Prognosis; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism; D016019:Survival Analysis; D014178:Translocation, Genetic
chemical_list: D000970:Antineoplastic Agents; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc
keywords: MYC rearrangements; cytogenetics and molecular genetics; multiple myeloma; outcome