title: Therapeutic Effect of Adipose Derived Stem Cells versus Atorvastatin on Amiodarone Induced Lung Injury in Male Rat.
abstract: OBJECTIVE
  Amiodarone (AM), a class 3 antiarrhythmic drug, has been associated with variety of adverse effects, the most serious of which is pulmonary toxicity. Ator (A) is a statin, known for their immunomodulatory and anti-inflammatory activities. Recent studies provide evidence of potential therapeutic effect of statins on lung injury. Adipose derived stem cells (ADSCs) have shown great promise in the repair of various tissues. The present study aimed at investigating and comparing the possible therapeutic effect of A and ADSCs on AM induced lung injury in albino rats.
  
  
  RESULTS
  34 adult male albino rats were divided into 5 groups: control group (Gp I), A group (Gp II) received 10 mg/kg of A orally 6 days (d)/week (w) for 4 weeks (ws), AM group (Gp III) received 30 mg/kg of AM orally 6 d/w for 4 ws, AM&A group (Gp IV) received AM for 4ws then A for other 4 ws and AM&SCs group (Gp V) received AM for 4 ws then injected with 0.5 ml ADSCs on 2 successive days intravenously (IV). Histological, histochemical, immunohistochemical and morphometric studies were performed. Group III displayed bronchiolitis obliterans, thickened interalveolar septa (IAS) and thickened vascular wall which were proven morphometrically. Increased area% of collagen fibers and apoptotic changes were recorded. All findings regressed on A administration and ADSCs therapy.
  
  
  CONCLUSIONS
  Ator proved a definite ameliorating effect on the degenerative, inflammatory, apoptotic and fibrotic changes induced by AM. ADSCs administration denoted more remarkable therapeutic effect compared to A.
authors.affiliation: Department of Histology, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Gihan Ibrahim
authors.initials: GI
authors.lastname: Aboul-Fotouh
authors.affiliation: Department of Histology, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Maha Baligh
authors.initials: MB
authors.lastname: Zickri
authors.affiliation: Department of Clinical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Hala Gabr
authors.initials: HG
authors.lastname: Metwally
authors.affiliation: Department of Histology, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Ihab Refaat
authors.initials: IR
authors.lastname: Ibrahim
authors.affiliation: Department of Histology, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Samaa Samir
authors.initials: SS
authors.lastname: Kamar
authors.affiliation: Department of Plastic Surgery, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
authors.forename: Wael
authors.initials: W
authors.lastname: Sakr
keywords: ADSCs; Amiodarone; Ator; Lung