title: A 3 tesla magnetic resonance imaging volumetric analysis of the hippocampal formation: dependence on handedness and age.
abstract: BACKGROUND
  The hippocampal formation (HF) is one of the most important parts of the brain in the magnetic resonance imaging (MRI) volumetric analysis in various domains, but not completely from all aspects, including the handedness. The aim of our study was to evaluate the possible differences in the volume of the right and left HF among the healthy right-handed and left-handed subjects, and to determine whether the volume differences are age related.
  
  
  METHODS
  The MRI of this prospective study was performed using T1 fast field echo (FFE) sequence. The 124 subsequent coronal slices (thickness 1.5 mm) were performed in each participant. The obtained HF volumes were normalised and statistically compared. Volunteers comprised 30 persons aged 22.0 years, 12 of whom were the left-handed, and 30 persons aged 75.2 years on average, 9 of whom were the left-handed.
  
  
  RESULTS
  The right and left HF volumes averaged 2.986 cm3 and 2.858 cm3 in the right-handed, and 2.879 cm³ and 3.020 cm³ in the left-handed young volunteers, as well as 2.728 cm³ and 2.650 cm³ in the right-handed, and 2.617 cm³ and 2.780 cm³ in the left-handed elderly persons. The HF volume ratios in the young left-handed participants showed a significant left-greater-than-right asymmetry. A significant difference was also noticed within the right-to-left volume ratios of the right- and left-handed young and elderly participants. The latter reduction in the HF volume within the aged group can be interpreted as a slight atrophy of the HF.
  
  
  CONCLUSIONS
  There is a significant difference in the volumes of the left and right HF of the left-handed young participants. The age related HF volume differences were proven between the groups of the young and elderly volunteers. The obtained data should be included into the future MRI studies of the HF volumes in various clinical domains.
authors.affiliation: dijana_lazic@dr.com.
authors.forename: D
authors.initials: D
authors.lastname: Lazić
authors.forename: T
authors.initials: T
authors.lastname: Stošić-Opinćal
authors.forename: N
authors.initials: N
authors.lastname: Petronijević
authors.forename: L
authors.initials: L
authors.lastname: Puškaš
authors.forename: V
authors.initials: V
authors.lastname: Djulejić
authors.forename: I
authors.initials: I
authors.lastname: Milić
authors.forename: S
authors.initials: S
authors.lastname: Marinković
keywords: aging; dentate gyrus; gender; handedness; hippocampus; magnetic resonance; volumetric analysis