title: Transcriptome profiling in Parkinson's leukocytes: from early diagnostics to neuroimmune therapeutic prospects.
abstract: Parkinson's disease (PD) involves motor symptoms reflecting the progressive degeneration of dopaminergic neurons in the substantia nigra. However, diagnosis is only enabled late in the disease, limiting treatment to palliative assistance. Here, we review recently generated transcriptional profiling datasets from blood and brain RNA of human PD cohorts and animal models that may offer unprecedented progress in PD research. Specifically, advanced analysis techniques demonstrated functionally inter-related underlying impairments of RNA metabolism and neuroimmune signalling processes. Identifying novel biomarkers in serum and nucleated blood cells, including protein networks and non-coding RNAs can drive discovery of the molecular mechanisms involved and reveal new targets for therapeutic intervention, posing a dual diagnosis/treatment opportunity for limiting the exacerbation of neuroinflammatory events in PD.
authors.affiliation: Department of Biological Chemistry and The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
authors.forename: Alon
authors.initials: A
authors.lastname: Simchovitz
authors.affiliation: Department of Molecular Neuroscience, UCL Institute of Neurology (ION), Queen Square, London WC1N 3BG, UK.
authors.forename: Lilach
authors.initials: L
authors.lastname: Soreq
authors.affiliation: Department of Biological Chemistry and The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. Electronic address: hermona.soreq@mail.huji.ac.il.
authors.forename: Hermona
authors.initials: H
authors.lastname: Soreq
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D017423:Sequence Analysis, RNA