title: Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa.
abstract: BACKGROUND
  Bismuth subgallate is a salt derived from heavy metal. The aim of this study was to evaluate the effect of this salt on some phases of healing.
  
  
  OBJECTIVE
  To assess the effect of subgallate on mucosa and to evaluate the association between the use of bismuth subgallate and neogenesis of vessels in oral mucosal wounds.
  
  
  METHODS
  This was a prospective and experimental study. This study used sixty rats, which were divided into control and experimental groups. The animals were submitted to a surgical procedure, which caused oral mucosal injury. A saline solution was applied on the wound of the control group, and in the experimental group, a solution of bismuth subgallate was administrated.
  
  
  RESULTS
  The experimental group showed greater inflammatory reaction with increasing monomorphic proliferation. There was increased vessel proliferation in the control group.
  
  
  CONCLUSIONS
  Bismuth subgallate had a negative influence on the healing process, delaying the rate of new vessel formation and optimal wound healing.
authors.affiliation: Department of Otorhinolaryngology, Hospital Universitário Evangélico de Curitiba (HUEC), Curitiba, PR, Brazil. Electronic address: eduardovcouto@gmail.com.
authors.forename: Eduardo Vieira
authors.initials: EV
authors.lastname: Couto
authors.affiliation: Department of Surgery, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil; Department of Surgery, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba, PR, Brazil.
authors.forename: Carlos Roberto
authors.initials: CR
authors.lastname: Ballin
authors.affiliation: Department of Surgery, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil; Department of Surgery, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba, PR, Brazil; Functional Rhinology, Irmandade Santa Casa de Misericórdia de Curitiba, Curitiba, PR, Brazil.
authors.forename: Claudia Paraguaçu Pupo
authors.initials: CP
authors.lastname: Sampaio
authors.affiliation: Functional Rhinology, Irmandade Santa Casa de Misericórdia de Curitiba, Curitiba, PR, Brazil.
authors.forename: Carlos Augusto Seije
authors.initials: CA
authors.lastname: Maeda
authors.affiliation: Department of Otorhinolaryngology, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba, PR, Brazil.
authors.forename: Carlos Henrique
authors.initials: CH
authors.lastname: Ballin
authors.affiliation: Department of Otorhinolaryngology, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba, PR, Brazil.
authors.forename: Camila Soares
authors.initials: CS
authors.lastname: Dassi
authors.affiliation: Department of Otorhinolaryngology, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba, PR, Brazil.
authors.forename: Lilian Yukari
authors.initials: LY
authors.lastname: Miura
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000098:blood supply / Q000601:surgery; D009942:Organometallic Compounds / Q000627:therapeutic use*; D011446:Prospective Studies; D051381:Rats; D014068:Tonsillectomy; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D043925:Angiogenesis Inducing Agents; D009942:Organometallic Compounds; D005707:Gallic Acid; C002170:bismuth subgallate
keywords: Angiogenesis-inducing agents; Cicatrização; Indutores da angiogênese; Tonsilectomia; Tonsillectomy; Wound healing