title: Association between well-known histopathological criteria and overall survival in invasive ductal carcinoma.
abstract: We investigated the effect of clinical features and well-known histomorphological parameters on survival of breast cancer.
  
  
  METHODS
  44 patients with invasive ductal carcinoma were included in this study. We investigated the effect of age, breast cancer location (right/left), histological grade, largest diameter of the tumor, lymphovascular and perineural invasion on patient survival. IBM SPSS (Statistical Package for Social Sciences) 20 program was used for statistics. Cox proportional hazard regression model for survival analysis, log-log plot, life function graphs were used. Results were 95% confidence interval, significance (P < 0.05).
  
  
  RESULTS
  In univariate analysis, the left breast localization, high histological grade, large tumor size, lymphovascular invasion, perineural invasion has been shown that reduced the overall survival (P < 0.05). In multivariate analysis, only high histological grade, large tumor size and perineural invasion were identified as parameters negatively associated with patient survival (P < 0.05). On univariate and multivariate analysis, age was not associated with survival.
  
  
  CONCLUSIONS
  The above results should be considered in the follow-up and treatment planning of invasive ductal carcinoma patients.
authors.affiliation: Department of Pathology, Faculty of Medicine, Dumlupinar University Kutahya, Turkey.
authors.forename: Aysenur
authors.initials: A
authors.lastname: Deger
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Dumlupinar University Kutahya, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Ozyigit
authors.affiliation: Department of Biostatistics, Faculty of Medicine, Dumlupinar University Kutahya, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Arik
authors.affiliation: Department of General Surgery, Kutahya Evliya Celebi Training and Research Hospital Kutahya, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Ekici
authors.affiliation: Department of Radiation Oncology, Kutahya Evliya Celebi Training and Research Hospital Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Cinkaya
authors.affiliation: Department of Pathology, Faculty of Medicine, Erzincan University Erzincan, Turkey.
authors.forename: Mahir
authors.initials: M
authors.lastname: Tayfur
authors.affiliation: Department of Neurosurgery, Kutahya Evliya Celebi Training and Research Hospital Kutahya, Turkey.
authors.forename: Hakki
authors.initials: H
authors.lastname: Deger
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000401:mortality* / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: Breast cancer; histopathological criteria; invasive ductal carcinoma; overall survival