title: The safety and efficacy of the preoperative neoadjuvant chemotherapy for patients with cervical cancer: a systematic review and meta analysis.
abstract: OBJECTIVE
  To evaluate the safety and efficacy of the preoperative neoadjuvant chemotherapy for patients with cervical cancer.
  
  
  METHODS
  A systematic literature search was conducted using the PubMed, EMBASE and Cochrane databases. Studies comparing combined neoadjuvant chemotherapy treatment (NACT)/radical surgery treatment (RST) with RST alone in patients with cervical cancer were eligible for inclusion.
  
  
  RESULTS
  Eight studies were finally included in this meta analysis, involving a total of 1302 patients. Meta analysis shows that NACT might have lower lymph node metastasis than RST [OR=0.57, 95% CI (0.41, 0.79), P=0.0008]. However, there are no differentiation between two groups in operation time [SMD=0.16, 95% CI (-0.08, 0.48), P=0.19], intraoperative estimated blood loss [SMD=0.20, 95% CI (-0.19, 0.58), P=0.48], intraoperative and postoperative complication rates [OR=1.33, 95% CI (0.45, 3.92), P=0.60], overall survival rate [OR=1.07, 95% CI (0.48, 2.41), P=0.86] and recurrence rate [OR=1.06, 95% CI (0.56, 2.03), P=0.85].
  
  
  CONCLUSIONS
  The safety and efficacy of two treatments are similarly. However, NACT can reduce the rate of lymph node metastasis, which is an independent risk factor for cervical cancer prognosis and may improve the prognosis of cervical cancer.
authors.affiliation: Department of Oncology, The Central Hospital of Enshi Autonomous Prefecture Enshi, Hubei Province, China.
authors.forename: Du
authors.initials: D
authors.lastname: He
authors.affiliation: Department of Oncology, The Central Hospital of Enshi Autonomous Prefecture Enshi, Hubei Province, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Duan
authors.affiliation: Department of Oncology, The Central Hospital of Enshi Autonomous Prefecture Enshi, Hubei Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Oncology, The Central Hospital of Enshi Autonomous Prefecture Enshi, Hubei Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lai
authors.affiliation: Department of Oncology, The Central Hospital of Enshi Autonomous Prefecture Enshi, Hubei Province, China.
authors.forename: Jiaquan
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Oncology, The Central Hospital of Enshi Autonomous Prefecture Enshi, Hubei Province, China.
authors.forename: Dian
authors.initials: D
authors.lastname: Chen
keywords: Cervical cancer; NACT; RST; meta analysis; preoperative neoadjuvant chemotherapy; radical surgery treatment