title: Don't Go Chasing Waterfalls: Excessive Fluid Resuscitation in Severe Sepsis and Septic Shock.
abstract: Aggressive fluid resuscitation is the mainstay therapy in modern sepsis management. Its efficacy was demonstrated in the landmark study by Emmanuel Rivers in 2001. However, more recent evidence largely shows that a positive fluid balance increases mortality in critically ill patients with sepsis. This article examines the theoretical benefits of fluid resuscitation and physiological responses to it that may negatively affect patients' outcome.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; and Adjunct Clinical Faculty, Graduate and Undergraduate Program, New York University College of Nursing, New York.
authors.forename: Leon
authors.initials: L
authors.lastname: Chen
mesh_terms: D064648:Critical Care Nursing; D016638:Critical Illness; D005440:Fluid Therapy / Q000009:adverse effects*; D006801:Humans; D018805:Sepsis / Q000628:therapy*; D012772:Shock, Septic / Q000628:therapy