title: Replication Origin Specification Gets a Push.
abstract: During the gap between G1 and S phases when replication origins are licensed and fired, it is possible that DNA translocases could disrupt pre-replicative complexes (pre-RCs). In this issue of Molecular Cell, Gros et al. (2015) find that pre-RCs can be pushed along DNA and retain the ability to support replication.
authors.affiliation: Molecular Cell, Cell Press, 50 Hampshire Street, 5(th) Floor, Cambridge, MA 02139, USA. Electronic address: bplosky@cell.com.
authors.forename: Brian S
authors.initials: BS
authors.lastname: Plosky
mesh_terms: D064110:Minichromosome Maintenance Proteins / Q000378:metabolism*; D018741:Replication Origin; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D064110:Minichromosome Maintenance Proteins