title: Supine sleep and obstructive sleep apnea syndrome in Parkinson's disease.
abstract: OBJECTIVE
  Supine sleep is associated with increased obstructive sleep apnea. People with Parkinson's disease (PD) complain about difficulties turning around in bed. The relationship between supine sleep and sleep-disordered breathing has never been explored in people with Parkinson's disease.
  
  
  METHODS
  Fifteen consecutive people with PD with severe Obstructive Sleep Apnea Syndrome (OSAS) were compared to: (1) 15 age-matched, gender-matched, body mass index-matched and Unified Parkinson's Disease Rating Scale-III score-matched people with PD without sleep-disordered breathing; (2) 11 age-matched and gender-matched people with severe obstructive sleep apnea syndrome (OSAS) alone; and (3) 11 age-matched and gender-matched healthy controls. Outcomes were: number of position changes during the night and per hour of sleep, and the percentage of sleep time spent in supine.
  
  
  RESULTS
  People with PD and severe OSAS spent most of their sleep time in the supine position (93 ± 11%); while people with PD without OSAS (61 ± 24%, p <0.001), people with isolated, severe OSAS (50 ± 28%, p <0.001), and the controls (40 ± 21, p <0.001) spent significantly less time on their back. People with PD and severe OSAS changed their position in bed per hour of sleep (0.4 ± 0.5) less frequently than those with PD without OSAS (1.1 ± 0.8, p = 0.002), those with isolated OSAS (1.2 ± 1.0, p = 0.006) and the controls (1.5 ± 0.5, p <0.001).
  
  
  CONCLUSIONS
  PD and severe OSAS are associated with a major reduction in the number of position changes and an increased supine sleep position during the night. For people with PD, alleviating the difficulties of turning around in bed might reduce the supine sleep position and improve sleep-disordered breathing.
authors.affiliation: Pôle Sommeil, Clinique Beau Soleil, Montpellier, France; EuroMov, Laboratoire Movement to Health (M2H), University of Montpellier-1, France; Centre d'Investigation Clinique, Hôpital Saint Eloi, Montpellier, France. Electronic address: valerie.cochen@gmail.com.
authors.forename: Valérie
authors.initials: V
authors.lastname: Cochen De Cock
authors.affiliation: Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Benard-Serre
authors.affiliation: Centre d'Investigation Clinique, Hôpital Saint Eloi, Montpellier, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Driss
authors.affiliation: Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France.
authors.forename: Manon
authors.initials: M
authors.lastname: Granier
authors.affiliation: Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Charif
authors.affiliation: Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Carlander
authors.affiliation: Pôle Sommeil, Clinique Beau Soleil, Montpellier, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Desplan
authors.affiliation: Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France.
authors.forename: Muriel
authors.initials: M
authors.lastname: Croisier Langenier
authors.affiliation: Clinique du Sommeil, CHU Pellegrin, Bordeaux, France; Unité Hypnologie et Chronobiologie Clinique, Pavillon de la Mutualité, Pessac, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Cugy
authors.affiliation: Pôle Sommeil, Clinique Beau Soleil, Montpellier, France; EuroMov, Laboratoire Movement to Health (M2H), University of Montpellier-1, France; Centre d'Investigation Clinique, Hôpital Saint Eloi, Montpellier, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Bayard
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000209:etiology / Q000503:physiopathology*; D016683:Supine Position / Q000502:physiology*
keywords: Akinesia; Obstructive sleep apnea syndrome; Parkinson's disease; Position changes; Supine sleep position