title: AGT M235t polymorphism and heart failure in a cohort of Tunisian population: diagnostic and prognostic value.
abstract: Activity of the renin-angiotensin Aldosterone system is increased in patients with heart failure (HF). The Angiotensinogen gene and specifically M235T polymorphism has been linked to susceptibility to hypertension, coronary heart disease and atrial fibrillation. Its role in heart failure is not yet sufficiently demonstrated. The aim of the present study was to assess the association between rs699 (M235T) polymorphism and heart failure in terms of diagnosis and prognosis. We included all patients over 20 years old consulting in the Emergency Department for acute dyspnea. According to the results of the B-type natriuretic peptide (BNP level), patients were divided into two groups: HF and non-HF group. DNA study was performed for all subjects and their genotypes were identified as TT, CT or CC. Mortality was followed for one year. We included 234 patients. We found the diagnosis of HF in 73 patients out of 160 (45%). Our results showed that the frequency of the T allele was higher in HF group patients than in non-HF group (69% vs. 33%, P<0.01). Patients carrying the TT and CT genotypes had a higher proportion of HF than those carrying the CC genotype (respectively 53% and 31% vs. 15%, P<0.01). According to multivariate analysis, TT genotype presented the highest risk of HF (OR=4.9 95% CI: 2.12-9.1) and the highest risk of death (OR=6.45 95% CI: 3.6-16.4) compared to the other two genotypes. The current study suggests that M235T polymorphism might be associated with increased risk of both HF and death.
authors.affiliation: Research Laboratory (LR12SP18) University of Monastir Tunisia Tunisia ; Research Unit: UR 12ES09 Dyslipidemia and Atherogenesis, Faculty of Medicine Monastir 5019, Tunisia.
authors.forename: Trabelsi
authors.initials: T
authors.lastname: Imen
authors.affiliation: Research Laboratory (LR12SP18) University of Monastir Tunisia Tunisia ; Department of Emergency, Fattouma Bourguiba University Hospital Monastir Tunisia.
authors.forename: Mohamed Habib
authors.initials: MH
authors.lastname: Grissa
authors.affiliation: Research Laboratory (LR12SP18) University of Monastir Tunisia Tunisia ; Department of Emergency, Fattouma Bourguiba University Hospital Monastir Tunisia.
authors.forename: Hamdi
authors.initials: H
authors.lastname: Boubaker
authors.affiliation: Research Laboratory (LR12SP18) University of Monastir Tunisia Tunisia ; Department of Emergency, Fattouma Bourguiba University Hospital Monastir Tunisia.
authors.forename: Kaouther
authors.initials: K
authors.lastname: Beltaief
authors.affiliation: Research Laboratory (LR12SP18) University of Monastir Tunisia Tunisia.
authors.forename: Salma
authors.initials: S
authors.lastname: Messous
authors.affiliation: Research Laboratory (LR12SP18) University of Monastir Tunisia Tunisia.
authors.forename: Nejia
authors.initials: N
authors.lastname: Tounsi
authors.affiliation: Research Unit: UR 12ES09 Dyslipidemia and Atherogenesis, Faculty of Medicine Monastir 5019, Tunisia.
authors.forename: Afef
authors.initials: A
authors.lastname: Slimani
authors.affiliation: Research Unit: UR 12ES09 Dyslipidemia and Atherogenesis, Faculty of Medicine Monastir 5019, Tunisia.
authors.forename: Chehaibi
authors.initials: C
authors.lastname: Khouloud
authors.affiliation: Research Laboratory (LR12SP18) University of Monastir Tunisia Tunisia ; Department of Emergency, Fattouma Bourguiba University Hospital Monastir Tunisia.
authors.forename: Wahid
authors.initials: W
authors.lastname: Bouida
authors.affiliation: Research Laboratory (LR12SP18) University of Monastir Tunisia Tunisia ; Department of Emergency, Sahloul University Hospital Sousse, Tunisia.
authors.forename: Riadh
authors.initials: R
authors.lastname: Boukef
authors.affiliation: Research Unit: UR 12ES09 Dyslipidemia and Atherogenesis, Faculty of Medicine Monastir 5019, Tunisia.
authors.forename: Mohammed Naceur
authors.initials: MN
authors.lastname: Slimene
authors.affiliation: Research Laboratory (LR12SP18) University of Monastir Tunisia Tunisia ; Department of Emergency, Fattouma Bourguiba University Hospital Monastir Tunisia.
authors.forename: Semir
authors.initials: S
authors.lastname: Nouira
keywords: Angiotensinogen; M235T; heart failure; mortality; polymorphism