title: Early motor development of children with a congenital cytomegalovirus infection.
abstract: BACKGROUND
  Congenital cytomegalovirus (cCMV) infection is the most important etiology of non-hereditary childhood hearing loss and an important cause of neurodevelopmental delay. The current study aimed to investigate the early motor development of symptomatic and asymptomatic cCMV infected children with and without sensorineural hearing loss (SNHL).
  
  
  METHODS
  Sixty-four children with a cCMV infection, without cerebral palsy, were compared to a control group of 107 normal hearing children. They were assessed around the ages of 6, 12, and 24 months with the Peabody Developmental Motor Scales-2 (PDMS-2), Alberta Infant Motor Scales (AIMS), and Ghent Developmental Balance Test (GDBT). The cCMV infected children were subdivided into a symptomatic (n=26) and asymptomatic cCMV group (n=38) but also into a cCMV group with SNHL (n=19) and without SNHL (n=45).
  
  
  RESULTS
  Symptomatic cCMV infected children and cCMV infected children with SNHL performed significantly weaker for all gross motor outcome measures.
  
  
  CONCLUSIONS
  A congenital CMV infection is a risk factor for a delay in the early motor development. Follow-up will be necessary to gain insight into the exact cause of this motor delay and to define the predictive value of early motor assessment of cCMV infected children.
authors.affiliation: Faculty of Medicine and Health Sciences, Department of Rehabilitation Sciences and Physiotherapy, Ghent University, Ghent, Belgium; Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium.
authors.forename: Alexandra
authors.initials: A
authors.lastname: De Kegel
authors.affiliation: Faculty of Medicine and Health Sciences, Department of Speech, Language and Hearing Sciences, Ghent University, Ghent, Belgium. Electronic address: LeenK.Maes@UGent.be.
authors.forename: Leen
authors.initials: L
authors.lastname: Maes
authors.affiliation: Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium; Faculty of Medicine and Health Sciences, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium.
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Dhooge
authors.affiliation: Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium; Faculty of Medicine and Health Sciences, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium.
authors.forename: Helen
authors.initials: H
authors.lastname: van Hoecke
authors.affiliation: Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium; Faculty of Medicine and Health Sciences, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium.
authors.forename: Els
authors.initials: E
authors.lastname: De Leenheer
authors.affiliation: Faculty of Medicine and Health Sciences, Department of Rehabilitation Sciences and Physiotherapy, Ghent University, Ghent, Belgium.
authors.forename: Hilde
authors.initials: H
authors.lastname: Van Waelvelde
mesh_terms: D058345:Asymptomatic Infections; D001530:Belgium / Q000453:epidemiology; D002657:Child Development; D003586:Cytomegalovirus Infections / Q000150:complications / Q000151:congenital / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000209:etiology; D006320:Hearing Tests / Q000379:methods; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009048:Motor Skills; D018570:Risk Assessment; D063189:Symptom Assessment / Q000379:methods / Q000706:statistics & numerical data
keywords: Asymptomatic; Congenital cytomegalovirus infection; Gross motor development; Sensorineural hearing loss; Symptomatic