title: Liver Function Assessment Using Parenchyma-Specific Contrast-Enhanced Ultrasonography.
abstract: The aim of this study was to assess hepatic functional reserve by analyzing the hepatic parenchyma enhancement curve of parenchyma-specific contrast-enhanced ultrasonography (CEUS). Fifty-two patients with cirrhosis who underwent CEUS and indocyanine green tests (ICG) because of a focal liver lesion were enrolled. We evaluated the hemodynamic-related parameters of the time-intensity curve and compared these findings with the ICG retention rate at 15 min (ICG R15). The correlation between the time from peak to one half (s) and ICG R15 was statistically significant and was relatively proportional to the ICG R15. A cut-off value of 149 s was determined for the time from peak to one half for abnormal ICG R15 (>14). The sensitivity and specificity were 85.7% and 92.3%, respectively, for the detection of abnormal ICG R15. In conclusion, the time from peak to one half of the time-intensity curve of parenchyma-specific CEUS of the liver can be a useful parameter to predict the hepatic reserve in liver cirrhosis.
authors.affiliation: Department of Radiology, Dong-A University College of Medicine, Busan, Republic of Korea.
authors.forename: Jaehyung
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Radiology, Dong-A University College of Medicine, Busan, Republic of Korea. Electronic address: jojini@dau.ac.kr.
authors.forename: Jinhan
authors.initials: J
authors.lastname: Cho
authors.affiliation: Department of Radiology, Dong-A University College of Medicine, Busan, Republic of Korea.
authors.forename: Heejin
authors.initials: H
authors.lastname: Kwon
authors.affiliation: Department of Radiology, Dong-A University College of Medicine, Busan, Republic of Korea.
authors.forename: Myongjin
authors.initials: M
authors.lastname: Kang
authors.affiliation: Department of Radiology, Dong-A University College of Medicine, Busan, Republic of Korea.
authors.forename: Sangyun
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Surgery, Dong-A University College of Medicine, Busan, Republic of Korea.
authors.forename: Young-hoon
authors.initials: YH
authors.lastname: Roh
authors.affiliation: Department of Surgery, Dong-A University College of Medicine, Busan, Republic of Korea.
authors.forename: Kwan Woo
authors.initials: KW
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Dong-A University College of Medicine, Busan, Republic of Korea.
authors.forename: Sung Wook
authors.initials: SW
authors.lastname: Lee
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003198:Computer Simulation; D003287:Contrast Media / Q000493:pharmacokinetics; D005260:Female; D005290:Ferric Compounds / Q000493:pharmacokinetics; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007501:Iron / Q000493:pharmacokinetics; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008111:Liver Function Tests / Q000379:methods*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D008954:Models, Biological; D010087:Oxides / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography / Q000379:methods*
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D010087:Oxides; C069727:Sonazoid; D007501:Iron
keywords: Contrast-enhanced ultrasonography; Indocyanine green; Liver cirrhosis; Liver function; Microbubble contrast agent; Sonazoid