title: Shared Genetic Etiology between Type 2 Diabetes and Alzheimer's Disease Identified by Bioinformatics Analysis.
abstract: Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two major health issues, and increasing evidence in recent years supports the close connection between these two diseases. The present study aimed to explore the shared genetic etiology underlying T2D and AD based on the available genome wide association studies (GWAS) data collected through August 2014. We performed bioinformatics analyses based on GWAS data of T2D and AD on single nucleotide polymorphisms (SNPs), gene, and pathway levels, respectively. Six SNPs (rs111789331, rs12721046, rs12721051, rs4420638, rs56131196, and rs66626994) were identified for the first time to be shared genetic factors between T2D and AD. Further functional enrichment analysis found lipid metabolism related pathways to be common between these two disorders. The findings may have important implications for future mechanistic and interventional studies for T2D and AD.
authors.forename: Lei
authors.initials: L
authors.lastname: Gao
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cui
authors.forename: Liang
authors.initials: L
authors.lastname: Shen
authors.forename: Hong-Fang
authors.initials: HF
authors.lastname: Ji
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D053302:Apolipoprotein C-I / Q000235:genetics*; D019295:Computational Biology / Q000379:methods* / Q000706:statistics & numerical data; D016208:Databases, Factual / Q000706:statistics & numerical data; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C505803:APOC1 protein, human; D053302:Apolipoprotein C-I
keywords: Alzheimer’s disease; SNPs; bioinformatics; genetic basis; genome wide association studies; type 2 diabetes