title: Hairy cell leukemia: Past, present and future.
abstract: This brief review highlights the sequence of therapeutic milestones and advances in our understanding of the biology of hairy cell leukemia (HCL) with a focus on recent molecular findings and how these may be applied to improve disease outcomes in the future. Targeted therapy is discussed in the context of the recently identified BRAF mutation and other genetic findings.
authors.affiliation: Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10065, USA. Electronic address: gettab@mskcc.org.
authors.forename: Bartlomiej M
authors.initials: BM
authors.lastname: Getta
authors.affiliation: Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10065, USA; Weill Cornell Medical College, 1305 York Avenue, New York 10021, USA. Electronic address: parkj6@mskcc.org.
authors.forename: Jae H
authors.initials: JH
authors.lastname: Park
authors.affiliation: Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10065, USA; Weill Cornell Medical College, 1305 York Avenue, New York 10021, USA. Electronic address: TallmanM@mskcc.org.
authors.forename: Martin S
authors.initials: MS
authors.lastname: Tallman
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001402:B-Lymphocytes / Q000187:drug effects* / Q000473:pathology; D017338:Cladribine / Q000627:therapeutic use; D019468:Disease Management; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D000922:Immunotoxins / Q000627:therapeutic use; D007211:Indoles / Q000627:therapeutic use*; D007943:Leukemia, Hairy Cell / Q000188:drug therapy* / Q000266:history* / Q000401:mortality / Q000601:surgery; D009154:Mutation; D015649:Pentostatin / Q000627:therapeutic use; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000276:immunology; D012074:Remission Induction; D000069283:Rituximab / Q000627:therapeutic use; D013156:Splenectomy; D013449:Sulfonamides / Q000627:therapeutic use*; D016019:Survival Analysis; D000077484:Vemurafenib
chemical_list: D000970:Antineoplastic Agents; D000922:Immunotoxins; D007211:Indoles; D013449:Sulfonamides; D000077484:Vemurafenib; D015649:Pentostatin; D017338:Cladribine; D000069283:Rituximab; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
keywords: BRAF; Hairy cell leukemia; Vemurafenib