title: The Role of Stereotactic Laser Amygdalohippocampotomy in Mesial Temporal Lobe Epilepsy.
abstract: Stereotactic laser amygdalohippocampotomy (SLAH) uses laser interstitial thermal therapy guided by magnetic resonance thermography. This novel intervention can achieve seizure freedom while minimizing collateral damage compared to traditional open surgery, in patients with mesial temporal lobe epilepsy. An algorithm is presented to guide treatment decisions for initial and repeat procedures in patients with and without mesial temporal sclerosis. SLAH may improve access by medication-refractory patients to effective surgical treatments and thereby decrease medical complications, increase productivity, and minimize socioeconomic consequences in patients with chronic epilepsy.
authors.affiliation: Department of Neurosurgery, Emory University School of Medicine, 1365 Clifton Road N.E., Atlanta, GA 30322, USA; Department of Neurology, Emory University School of Medicine, 101 Woodruff Circle, Suite 6111, Atlanta, GA 30322, USA; Interventional MRI Program, Emory University Hospital, 1364 Clifton Road, N.E., Atlanta, GA 30322, USA; Coulter Department of Biomedical Engineering, Emory University, 1760 Haygood Dr, Ste W 200, Atlanta, GA 30322, USA. Electronic address: rgross@emory.edu.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Gross
authors.affiliation: Department of Neurosurgery, Emory University School of Medicine, 1365 Clifton Road N.E., Atlanta, GA 30322, USA; Department of Neurology, Emory University School of Medicine, 101 Woodruff Circle, Suite 6111, Atlanta, GA 30322, USA; Interventional MRI Program, Emory University Hospital, 1364 Clifton Road, N.E., Atlanta, GA 30322, USA.
authors.forename: Jon T
authors.initials: JT
authors.lastname: Willie
authors.affiliation: Department of Neurology, Emory University School of Medicine, 101 Woodruff Circle, Suite 6111, Atlanta, GA 30322, USA; Department of Neurology, University of Washington School of Medicine, Harborview Medical Center, 325 9th Avenue, Seattle, WA 98104, USA.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Drane
mesh_terms: D000465:Algorithms; D000679:Amygdala / Q000601:surgery*; D000066491:Clinical Decision-Making; D004833:Epilepsy, Temporal Lobe / Q000601:surgery*; D006624:Hippocampus / Q000601:surgery*; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D013238:Stereotaxic Techniques; D016896:Treatment Outcome
keywords: Ablation; Anterior temporal lobectomy; Laser; Memory; Mesial temporal lobe epilepsy; Mesial temporal sclerosis; Neuropsychology; Selective amygdalohippocampectomy