title: Effectiveness and Safety of Manufactured Chinese Herbal Formula for Knee Osteoarthritis: Insights from a Systematic Review.
abstract: Objective. To assess the current clinical evidence of manufactured Chinese herbal formulae (MCHF) for knee osteoarthritis (KOA). Methods. Seven databases were searched from inception to May 2015. Eligible randomized controlled trials investigating the effectiveness of MCHF for KOA were included. Data extraction, methodological assessment, and meta-analyses were conducted according to the Cochrane standards. Results. A total of 17 kinds of MCHF were identified from the twenty-six included trials. Meta-analyses showed that MCHF significantly relieved the global pain of knee joints, either used alone or combined with routine treatments. Additionally, MCHF plus routine treatments significantly decreased the scores of WOMAC and Lequesne index. However, there were no statistical differences between MCHF group and routine treatment group in walk-related pain and WOMAC scores. No significant differences were found in Lysholm scores. There were twenty-one trials that mentioned adverse events. A pooled analysis showed that adverse events occurred more frequently in control group compared with MCHF group. Conclusions. Our results indicated that MCHF showed some potential benefits for KOA. However, we still cannot draw firm conclusions due to the poor methodological quality of included trials. More high-quality RCTs would help to confirm the evidence.
authors.affiliation: Department of Spine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Huajiadi Street, Chaoyang District, Beijing 100102, China.
authors.forename: Liguo
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Spine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Huajiadi Street, Chaoyang District, Beijing 100102, China ; Department of Spine, The First Hospital of Hunan University of Chinese Medicine, No. 95 Middle Shaoshan Street, Yuhua District, Changsha 410007, China.
authors.forename: Shaofeng
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of General Orthopedics, Wangjing Hospital, China Academy of Chinese Medical Sciences, Huajiadi Street, Chaoyang District, Beijing 100102, China.
authors.forename: Shangquan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Orthopaedics, Changping Hospital of Integrated Chinese and Western Medicine, No. 219 Huangping Street, Changping District, Beijing 102208, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Gong
authors.affiliation: Department of Spine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Huajiadi Street, Chaoyang District, Beijing 100102, China.
authors.forename: Linghui
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Scientific Research, Wangjing Hospital, China Academy of Chinese Medical Sciences, Huajiadi Street, Chaoyang District, Beijing 100102, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wei