title: Development and Suggestion of a Cardiac CTA Scoring System for the Prediction of Revascularization Success in Chronic Total Occlusions (CTO) of the Coronary Arteries.
abstract: OBJECTIVE
  Analyzing occluded segments with computed tomography angiography (CTA) prior to percutaneous coronary intervention (PCI) increased revascularization success in chronic total occlusions (CTO). The aim of our study was to develop a scoring system for the prediction of PCI success in CTO.
  
  
  METHODS
  41 consecutive CTO patients (30 male; 63.1 years +/- 8.3 standard deviation) underwent CTA prior to PCI. All CTOs were categorized by two radiologists in consensus regarding the presence of special features and without knowledge of PCI outcome. All outcome criteria were evaluated. Afterwards one point was assigned for each unequally distributed outcome criteria per CTO and all points were added up to a single score.
  
  
  RESULTS
  Severe calcifications (failure group 68.8 % vs. success group 28.0 %; p < 0.02) and intraluminal calcifications (68.8 %; 40.0 %), tortuosity (25.0 %; 0 %; p < 0.02), linear intrathrombus enhancement (37.5 %; 60.0 %) and distal vessel disease (68.8 %; 44.0 %) were unequally distributed. By adopting a threshold of 4 points or higher (maximum 5 points), the results were: sensitivity 31.3 %, specificity 100 %, negative predictive value (NPV) 69.4 % and positive predictive value (PPV) 100 %. The PCI complication rate was 9.8 % and the mean contrast media amount was 234.4 ml.
  
  
  CONCLUSIONS
  With the suggested scoring system, based on five CTA criteria, PCI failure could be predicted with high PPV and specificity in our group of patients, but the NPV and sensitivity are low. However, 5 unsuccessful PCIs (13.2 %) could have been avoided and none would have been wrongly omitted. Regarding the complication rate during PCI and the high amounts of contrast media needed, a prediction system appears to be desirable and should be the object of large-scale trials.
  
  
  CONCLUSIONS
  Single predictors of revascularization success in CTO have been identified. Success rates are improved by analyzing CTA data sets prior to revascularization approaches. Prediction of revascularization success via a scoring system based on five CTA criteria seems promising. Patient selection for the right treatment options might be improved in the future due to application of the scoring system. Also risks, complications, contrast media amounts and radiation doses might be reduced.
authors.affiliation: Department of Radiology, Justus Liebig University Giessen, Giessen, Germany.
authors.forename: F C
authors.initials: FC
authors.lastname: Roller
authors.affiliation: Department of Radiology, Justus Liebig University Giessen, Giessen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Harth
authors.affiliation: Department of Cardiology, Justus Liebig University Giessen, Giessen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Rixe
authors.affiliation: Department of Radiology, Justus Liebig University Giessen, Giessen, Germany.
authors.forename: G A
authors.initials: GA
authors.lastname: Krombach
authors.affiliation: Department of Radiology, Justus Liebig University Giessen, Giessen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Schneider
mesh_terms: D000368:Aged; D017023:Coronary Angiography / Q000379:methods*; D054059:Coronary Occlusion / Q000000981:diagnostic imaging* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D009204:Myocardial Revascularization / Q000379:methods*; D011379:Prognosis; D016896:Treatment Outcome