title: Prognostic effect of high-flux hemodialysis in patients with chronic kidney disease.
abstract: We investigated the prognostic effects of high-flux hemodialysis (HFHD) and low-flux hemodialysis (LFHD) in patients with chronic kidney disease (CKD). Both an electronic and a manual search were performed based on our rigorous inclusion and exclusion criteria to retrieve high-quality, relevant clinical studies from various scientific literature databases. Comprehensive meta-analysis 2.0 (CMA 2.0) was used for the quantitative analysis. We initially retrieved 227 studies from the database search. Following a multi-step screening process, eight high-quality studies were selected for our meta-analysis. These eight studies included 4967 patients with CKD (2416 patients in the HFHD group, 2551 patients in the LFHD group). The results of our meta-analysis showed that the all-cause death rate in the HFHD group was significantly lower than that in the LFHD group (OR=0.704, 95%CI=0.533-0.929, P=0.013). Additionally, the cardiovascular death rate in the HFHD group was significantly lower than that in the LFHD group (OR=0.731, 95%CI=0.616-0.866, P<0.001). The results of this meta-analysis clearly showed that HFHD decreases all-cause death and cardiovascular death rates in patients with CKD and that HFHD can therefore be implemented as one of the first therapy choices for CKD.
authors.affiliation: The Hemodialysis Room, Xiangya Hospital of Central South University, Changsha, P.R., China.
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.affiliation: The Hemodialysis Room, Xiangya Hospital of Central South University, Changsha, P.R., China.
authors.forename: H
authors.initials: H
authors.lastname: Xu
authors.affiliation: The Hemodialysis Room, Xiangya Hospital of Central South University, Changsha, P.R., China.
authors.forename: X C
authors.initials: XC
authors.lastname: Xiao
authors.affiliation: Department of Educational Administration, Xiangya Hospital of Central South University, Changsha, P.R., China.
authors.forename: S L
authors.initials: SL
authors.lastname: Deng
authors.affiliation: The Hemodialysis Room, Xiangya Hospital of Central South University, Changsha, P.R., China.
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.affiliation: The Hemodialysis Room, Xiangya Hospital of Central South University, Changsha, P.R., China.
authors.forename: R
authors.initials: R
authors.lastname: Tang
mesh_terms: D015982:Bias; D002318:Cardiovascular Diseases / Q000401:mortality; D016022:Case-Control Studies; D002423:Cause of Death; D018450:Disease Progression; D006801:Humans; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000628:therapy*; D011379:Prognosis; D017594:Publication Bias / Q000706:statistics & numerical data; D012044:Regression Analysis; D006435:Renal Dialysis / Q000379:methods*; D051436:Renal Insufficiency, Chronic / Q000401:mortality; D012680:Sensitivity and Specificity