title: Investigation of the association between interleukin-10 polymorphisms and risk of acute pancreatitis in a Chinese population.
abstract: We conducted a case-control study to investigate the possible association between three common single nucleotide polymorphisms in interleukin-10 (IL-10) and the development of acute pancreatitis in a Chinese population. Between January 2013 and December 2014, 255 patients with acute pancreatitis and 255 control subjects were recruited for the study. Genotyping of IL-10 rs1800896, rs1800871, and rs1800872 was performed using polymerase chain reaction coupled with restriction fragment length polymorphism. Using logistic regression analysis, we found that the AA genotype of IL-10 rs1800896 was correlated with an increased risk of acute pancreatitis in a codominant model (OR = 2.44, 95%CI = 1.28-4.77). In a dominant model, we found that the GA+AA genotype of IL-10 rs1800896 was associated with an elevated risk of acute pancreatitis (OR = 1.51, 95%CI = 1.05-2.18). In a recessive model, the AA genotype of IL-10 rs1800896 was correlated with an increased risk of acute pancreatitis (OR = 1.98, 95%CI = 1.06-3.77). In conclusion, IL-10 rs1800896 was correlated with an increased risk of acute pancreatitis in codominant, dominant, and recessive models.
authors.affiliation: Department of Emergency, The Second Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou, China.
authors.forename: H L
authors.initials: HL
authors.lastname: Jia
authors.affiliation: Department of Cardiology, Henan Chest Hospital, Zhengzhou, China.
authors.forename: P L
authors.initials: PL
authors.lastname: Sun
authors.affiliation: Department of Emergency, The Second Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou, China.
authors.forename: C Q
authors.initials: CQ
authors.lastname: Lu
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D016753:Interleukin-10