title: High burden of RSV hospitalization in very young children: a data linkage study.
abstract: Linked administrative population data were used to estimate the burden of childhood respiratory syncytial virus (RSV) hospitalization in an Australian cohort aged <5 years. RSV-coded hospitalizations data were extracted for all children aged <5 years born in New South Wales (NSW), Australia between 2001 and 2010. Incidence was calculated as the total number of new episodes of RSV hospitalization divided by the child-years at risk. Mean cost per episode of RSV hospitalization was estimated using public hospital cost weights. The cohort comprised of 870 314 children. The population-based incidence/1000 child-years of RSV hospitalization for children aged <5 years was 4·9 with a rate of 25·6 in children aged <3 months. The incidence of RSV hospitalization (per 1000 child-years) was 11·0 for Indigenous children, 81·5 for children with bronchopulmonary dysplasia (BPD), 10·2 for preterm children with gestational age (GA) 32-36 weeks, 27·0 for children with GA 28-31 weeks, 39·0 for children with GA <28 weeks and 6·7 for term children with low birthweight. RSV hospitalization was associated with an average annual cost of more than AUD 9 million in NSW. RSV was associated with a substantial burden of childhood hospitalization specifically in children aged <3 months and in Indigenous children and children born preterm or with BPD.
authors.affiliation: Discipline of Paediatrics,School of Women's and Children's Health,Faculty of Medicine,UNSWAustralia.
authors.forename: N
authors.initials: N
authors.lastname: Homaira
authors.affiliation: Discipline of Paediatrics,School of Women's and Children's Health,Faculty of Medicine,UNSWAustralia.
authors.forename: J-L
authors.initials: JL
authors.lastname: Oei
authors.affiliation: Discipline of Paediatrics,School of Women's and Children's Health,Faculty of Medicine,UNSWAustralia.
authors.forename: K-A
authors.initials: KA
authors.lastname: Mallitt
authors.affiliation: Department of Neonatology,Centenary Hospital,Australian National University.
authors.forename: M E
authors.initials: ME
authors.lastname: Abdel-Latif
authors.affiliation: National Perinatal Epidemiology & Statistics Unit,Centre for Big Data Research in Health and School of Women's and Children's Health,UNSWAustralia.
authors.forename: L
authors.initials: L
authors.lastname: Hilder
authors.affiliation: NSW Pregnancy and Newborn Services Network,Sydney Children's Hospitals Network,Westmead,NSW,Australia.
authors.forename: B
authors.initials: B
authors.lastname: Bajuk
authors.affiliation: Discipline of Paediatrics,School of Women's and Children's Health,Faculty of Medicine,UNSWAustralia.
authors.forename: K
authors.initials: K
authors.lastname: Lui
authors.affiliation: Public Health Unit,South Eastern Sydney Local Health District,NSW,Australia.
authors.forename: M
authors.initials: M
authors.lastname: Ferson
authors.affiliation: Public Health Unit,South Eastern Sydney Local Health District,NSW,Australia.
authors.forename: A
authors.initials: A
authors.lastname: Nurkic
authors.affiliation: National Perinatal Epidemiology & Statistics Unit,Centre for Big Data Research in Health and School of Women's and Children's Health,UNSWAustralia.
authors.forename: G M
authors.initials: GM
authors.lastname: Chambers
authors.affiliation: Serology and Virology Division,SEALS Microbiology,Prince of Wales Hospital,Randwick,NSW,Australia.
authors.forename: W
authors.initials: W
authors.lastname: Rawlinson
authors.affiliation: Princess Margaret Hospital,Perth,Western Australia.
authors.forename: T
authors.initials: T
authors.lastname: Snelling
authors.affiliation: Discipline of Paediatrics,School of Women's and Children's Health,Faculty of Medicine,UNSWAustralia.
authors.forename: A
authors.initials: A
authors.lastname: Jaffe
mesh_terms: D002675:Child, Preschool; D005260:Female; D017048:Health Care Costs; D006760:Hospitalization / Q000191:economics*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D016247:Information Storage and Retrieval; D008297:Male; D009517:New South Wales / Q000453:epidemiology; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000473:pathology*; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification*; D012189:Retrospective Studies
keywords: Epidemiology; estimating disease prevalence; global vaccine issues; infectious disease epidemiology; paediatrics