title: Evaluation of the retinal ganglion cell and choroidal thickness in young Turkish adults with hyperopic anisometropic amblyopia.
abstract: The purpose of this study is to compare the choroidal thickness (CT) and ganglion cell complex (GCC) thickness of the normal fellow eyes and the amblyopic eyes using enhanced depth imaging optical coherence tomography (EDI-OCT) in young Turkish adults with hyperopic anisometropic amblyopia. Patients with unilateral hyperopic anisometropic amblyopia were enrolled and underwent a full ophthalmological assessment, including best-corrected visual acuity, cycloplegic refraction, and axial length (AL) measurements. Cirrus EDI-OCT was used to obtain subfoveal CT, GCC thickness, retinal nerve fiber layer (RNFL), and central macular thickness (CMT) measurements. Comparison was performed between the amblyopic eyes and the normal fellow eyes. Forty-three hyperopic anisometropic amblyopic patients were enrolled in this study. Mean age of 23 female and 20 male patients was 24.8 ± 7.4 years. Mean AL was 21.9 ± 1.3 and 22.4 ± 0.9 mm in amblyopic and fellow eyes, respectively (P < 0.05). Mean subfoveal CT measurements were 325.4 ± 44.2 and 317.9 ± 42.7 µ in amblyopic and fellow eyes, respectively. There was no statistically significant difference between the groups (P > 0.05). Mean GCC thickness was 83.8 ± 3.6 µ in amblyopic eyes and 83.5 ± 3.9 µ in the fellow eyes. Statistically significant difference was not seen between the groups (P > 0.05). Mean RNFL and mean CMT measurements were also similar in two groups (P > 0.05). Subfoveal CT, CMT, RNFL, and GCC thickness measurements were not statistically significant between hyperopic anisometropic amblyopic eyes and normal fellow eyes.
authors.affiliation: Sakarya University Medical Education and Research Hospital, Sakarya, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Celik
authors.affiliation: Sakarya University Medical Education and Research Hospital, Sakarya, Turkey.
authors.forename: Burçin
authors.initials: B
authors.lastname: Çakır
authors.affiliation: Akdeniz University Hospital, Antalya, Turkey. drelifbetul@yahoo.com.
authors.forename: Elif Betul
authors.initials: EB
authors.lastname: Turkoglu
authors.affiliation: Sakarya University Medical Education and Research Hospital, Sakarya, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Doğan
authors.affiliation: Sakarya University Medical Education and Research Hospital, Sakarya, Turkey.
authors.forename: Gursoy
authors.initials: G
authors.lastname: Alagoz
mesh_terms: D000328:Adult; D000550:Amblyopia / Q000473:pathology*; D015858:Anisometropia / Q000473:pathology*; D002829:Choroid / Q000473:pathology*; D005260:Female; D006801:Humans; D006956:Hyperopia / Q000473:pathology*; D008297:Male; D009929:Organ Size; D012029:Refraction, Ocular / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014421:Turkey; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
keywords: Amblyopia; Choroidal thickness; Ganglion cell complex