title: Clinical efficacy of deep brain stimulation for the treatment of medically refractory epilepsy.
abstract: Epilepsy affects 50 million people worldwide and about 30% of these patients will not be adequately controlled with antiepileptic drugs (AEDs) alone. For patients where resective surgery is not indicated, deep brain stimulation (DBS) may be an effective alternative. The majority of available literature targets the thalamic nuclei (anterior; centromedian), subthalamic nucleus, hippocampus, and cerebellum. Here, we review patient outcomes and adverse events related to DBS to these various targets. Data show DBS may be a safe and effective treatment option for refractory epilepsy.
authors.affiliation: Department of Neurosurgery, Wayne State University, Detroit, MI, USA; Comprehensive Epilepsy Center, Wayne State University and Harper University Hospital, Detroit, MI, USA.
authors.forename: Neil V
authors.initials: NV
authors.lastname: Klinger
authors.affiliation: Department of Neurosurgery, Wayne State University, Detroit, MI, USA; Comprehensive Epilepsy Center, Wayne State University and Harper University Hospital, Detroit, MI, USA. Electronic address: smittal@med.wayne.edu.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Mittal
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D046690:Deep Brain Stimulation; D004827:Epilepsy / Q000628:therapy*; D006624:Hippocampus / Q000187:drug effects / Q000601:surgery*; D006801:Humans; D020531:Subthalamic Nucleus / Q000187:drug effects / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants
keywords: Brain stimulation; Castatrophic epilepsy; Epilepsy surgery; Medically-refractory epilepsy; Responsive direct neurostimulation; Seizures