title: Oral Immunotherapy for Food Allergy.
abstract: Food allergy is a potentially life-threatening condition with no approved therapies, apart from avoidance and injectable epinephrine for acute allergic reactions. Oral immunotherapy (OIT) is an experimental treatment in which food-allergic patients consume gradually increasing quantities of the food to increase their threshold for allergic reaction. This therapy carries significant risk of allergic reactions. The ability of OIT to desensitize patients to particular foods is well-documented, although the ability to induce tolerance has not been established. This review focuses on recent studies for the treatment of food allergies such as cow's milk, hen's egg, and peanut.
authors.affiliation: Department of Rheumatology, Allergy, and Immunology, University of North Carolina, CB #7231, Chapel Hill, NC 27599, USA.
authors.forename: Allison J
authors.initials: AJ
authors.lastname: Burbank
authors.affiliation: Department of Pediatrics, University of Maryland Children's Hospital, Baltimore, MD 21201, USA.
authors.forename: Puja
authors.initials: P
authors.lastname: Sood
authors.affiliation: Department of Rheumatology, Allergy, and Immunology, University of North Carolina, CB #7231, Chapel Hill, NC 27599, USA. Electronic address: bvickery@email.unc.edu.
authors.forename: Brian P
authors.initials: BP
authors.lastname: Vickery
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Wood
mesh_terms: D000284:Administration, Oral; D000485:Allergens / Q000276:immunology*; D000818:Animals; D010367:Arachis / Q000276:immunology; D002417:Cattle; D003888:Desensitization, Immunologic; D004527:Egg Proteins / Q000276:immunology; D005512:Food Hypersensitivity / Q000276:immunology / Q000628:therapy*; D006801:Humans; D008894:Milk Proteins / Q000276:immunology
chemical_list: D000485:Allergens; D004527:Egg Proteins; D008894:Milk Proteins
keywords: Desensitization; Food allergy; Immunoglobulin E (IgE); Omalizumab; Oral immunotherapy (OIT); Skin prick test (SPT); Sustained unresponsiveness; Tolerance