title: Diagnosis and therapies for gastric non-invasive neoplasia.
abstract: There has been a great discrepancy of pathological diagnosis for gastric non-invasive neoplasia/dysplasia between Japanese and western pathologists. In Japan, lesions that most western pathologists diagnose as dysplasia are often considered adenocarcinoma based on nuclear and structural atypia regardless of the presence of invasion. In the Vienna classification, gastric non-invasive intraepithelial neoplasia (NIN) were divided into low grade and high grade (including intra-mucosal cancer of Japanese criteria). The diagnosis by both endoscopy and pathology of biopsy specimen is difficult. Recent advances of diagnostic modality such as magnified endoscopy and imaged enhanced endoscopy is expected to improve the diagnostic yield for NIN. There are two treatment strategies for NIN, observation and diagnostic therapy by endoscopic resection (ER). ER is acceptable because of its less invasiveness and high local control rate, on the other hand, cancer-developing rate of low-grade NIN is reported to be low. Therefore there is controversy for the treatment of gastric NIN. Prospective study based on unified pathological definition is required in the future.
authors.affiliation: Motohiko Kato, Department of Gastroenterology, National Hospital Organization Tokyo Medical Center, Tokyo 152-8902, Japan.
authors.forename: Motohiko
authors.initials: M
authors.lastname: Kato
mesh_terms: D000236:Adenoma / Q000473:pathology* / Q000601:surgery*; D001706:Biopsy; D002278:Carcinoma in Situ / Q000473:pathology* / Q000601:surgery*; D005743:Gastrectomy / Q000379:methods*; D005773:Gastroscopy; D006801:Humans; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D011237:Predictive Value of Tests; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome; D057832:Watchful Waiting
keywords: Adenocarcinoma; Adenoma; Diagnosis; Gastric; Non invasive intraepithelial neoplasia