title: Management of Prostate Cancer in the Elderly.
abstract: The impact of localized prostate cancer in the elderly depends on disease aggressiveness and life expectancy. In men with localized prostate cancer, those with low-risk disease or a shorter life expectancy should be managed expectantly, whereas those with long life expectancy or more aggressive disease may benefit from curative treatment. Comorbidity and quality-of-life concerns are key considerations during the selection of therapeutic modalities in the elderly in localized and metastatic settings. A variety of new agents have changed the therapeutic landscape in castrate-resistant prostate cancer, but their benefits need to be considered alongside their side effects and cost.
authors.affiliation: Division of Urology, Duke University Medical Center, DUMC Box 103861, Durham, NC 27710, USA.
authors.forename: Kae Jack
authors.initials: KJ
authors.lastname: Tay
authors.affiliation: Division of Urology, Duke University Medical Center, DUMC Box 103861, Durham, NC 27710, USA.
authors.forename: Judd W
authors.initials: JW
authors.lastname: Moul
authors.affiliation: Department of Medical Oncology, Duke University Medical Center, DUMC Box 103861, Durham, NC 27710, USA. Electronic address: andrew.armstrong@dm.duke.edu.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Armstrong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D019468:Disease Management; D019317:Evidence-Based Medicine; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000628:therapy*; D012307:Risk Factors; D012944:Social Support
keywords: Elderly; Geriatric; Localized; Metastatic; Oncology; Prostate cancer; Radiation; Surgery