title: Toxins Secreted by Bacillus Isolated from Lung Adenocarcinomas Favor the Penetration of Toxic Substances.
abstract: The aim was to explore the eventual role of bacteria in the induction of lung cancer by smoking habits. Viable bacteria closely related to the genus Bacillus were detected at high frequencies in lung-cancer biopsies. Similar, if not identical, microbes were isolated from cigarettes and in smog. Bacteria present in cigarettes could be transferred to a physiological solution via a "smoker" device that mimicked their potential transfer during smoking those bacteria produce exotoxins able to open transmembrane pores. These channels can be used as a way to penetrate cells of benzopyrenes and other toxic substances present in tobacco products. We hypothesize that Bacillaceae present in tobacco play a key role in the development of lung cancer.
authors.affiliation: Molecular Microbiology and Antibiotics, Department of Pathology and Experimental Therapeutics, Medical School, University of Barcelona Barcelona, Spain.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Merlos
authors.affiliation: Department of Thoracic Surgery, Hospital Universitari de Bellvitge, University of Barcelona-IDIBELL-HUB Barcelona, Spain.
authors.forename: Pau
authors.initials: P
authors.lastname: Rodríguez
authors.affiliation: MoLife, Jacobs University Bremen, Germany.
authors.forename: Iván
authors.initials: I
authors.lastname: Bárcena-Uribarri
authors.affiliation: MoLife, Jacobs University Bremen, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Winterhalter
authors.affiliation: MoLife, Jacobs University Bremen, Germany.
authors.forename: Roland
authors.initials: R
authors.lastname: Benz
authors.affiliation: Molecular Microbiology and Antibiotics, Department of Pathology and Experimental Therapeutics, Medical School, University of Barcelona Barcelona, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Vinuesa
authors.affiliation: Department of Thoracic Surgery, Hospital Universitari de Bellvitge, University of Barcelona-IDIBELL-HUB Barcelona, Spain.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Moya
authors.affiliation: Molecular Microbiology and Antibiotics, Department of Pathology and Experimental Therapeutics, Medical School, University of Barcelona Barcelona, Spain ; Cooperativa de Ensino Superior Politécnico e Universitário, IINFACTS Gandra, Portugal.
authors.forename: Miguel
authors.initials: M
authors.lastname: Viñas
keywords: Bacillus; cigarette; lung cancer; toxin; transmembrane channels