title: Efficiency and safety of surgical intervention to patients with Non-Cystic Fibrosis bronchiectasis: a meta-analysis.
abstract: No quantitative systematic review was found to report the efficiency and safety of surgical resection in the management of non-cystic fibrosis (non-CF) bronchiectasis. We therefore conducted a meta-analysis to assess the effects of operative intervention to patients with non-CF bronchiectasis. PubMed, the Cochrane library and Web of Science databases were searched up to July 8th, 2015. The pooled mortality from 34 studies recruiting 4788 patients was 1.5% (95% CI, 0.9-2.5%). The pooled morbidity from 33 studies consisting of 4583 patients was 16.7% (95% CI, 14.8-18.6%). The pooled proportion of patients from 35 studies, consisting of 4614 patients who were free of symptoms was 66.5% (95% CI, 61.3-71.7%) after surgery. The summary proportion of patients from 35 articles including 4279 participants who were improved was 27.5% (95% CI, 22.5-32.5%), and 9.1% (95% CI, 7.3-11.5%) showed no clinical improvement. In conclusion, our analysis indicated that lung resection in the management of non-CF bronchiectasis is associated with significant improvements in symptoms, low risk of mortality and acceptable morbidity.
authors.affiliation: Department of Respiratory Medicine, Shanghai pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Li-Chao
authors.initials: LC
authors.lastname: Fan
authors.affiliation: Department of Respiratory Medicine, Shanghai pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Liang
authors.affiliation: Department of Respiratory Medicine, Shanghai pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Hai-Wen
authors.initials: HW
authors.lastname: Lu
authors.affiliation: Department of Thoracic Surgery, Shanghai pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Fei
authors.affiliation: Department of Respiratory Medicine, Shanghai pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Jin-Fu
authors.initials: JF
authors.lastname: Xu
mesh_terms: D001987:Bronchiectasis / Q000401:mortality / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D039781:PubMed; D012449:Safety; D013514:Surgical Procedures, Operative / Q000009:adverse effects / Q000379:methods*; D015996:Survival Rate