title: DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer.
abstract: For decades, radiotherapy and chemotherapy were the two only approaches exploiting DNA repair processes to fight against cancer. Nowadays, cancer therapeutics can be a major challenge when it comes to seeking personalized targeted medicine that is both effective and selective to the malignancy. Over the last decade, the discovery of new targeted therapies against DNA damage signalling and repair has offered the possibility of therapeutic improvements in oncology. In this review, we summarize the current knowledge of DNA damage signalling and repair inhibitors, their molecular and cellular effects, and future therapeutic use.
authors.affiliation: Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Axis, 9 McMahon, Québec City, QC G1R-2J6, Canada. velic.d@gmail.com.|Department of Molecular Biology, Medical Biochemistry and Pathology, Centre de Recherche sur le Cancer, Laval University, Québec City, QC G1V-0A6, Canada. velic.d@gmail.com.|DNA repair regulation team, UFIP, CNRS UMR 6286, Université de Nantes, 2 rue de la Houssinière, Nantes 44322, France. velic.d@gmail.com.
authors.forename: Denis
authors.initials: D
authors.lastname: Velic
authors.affiliation: Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Axis, 9 McMahon, Québec City, QC G1R-2J6, Canada. anthony.couturier.1@gmail.com.|Department of Molecular Biology, Medical Biochemistry and Pathology, Centre de Recherche sur le Cancer, Laval University, Québec City, QC G1V-0A6, Canada. anthony.couturier.1@gmail.com.
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Couturier
authors.affiliation: Department of Molecular Biology, Medical Biochemistry and Pathology, Centre de Recherche sur le Cancer, Laval University, Québec City, QC G1V-0A6, Canada. maria.tedim-ferreira.1@ulaval.ca.|CHU de Québec Research Center, Oncology Axis, 2705 boul. Laurier, Quebec city, QC G1V-4G2, Canada. maria.tedim-ferreira.1@ulaval.ca.
authors.forename: Maria Tedim
authors.initials: MT
authors.lastname: Ferreira
authors.affiliation: Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Axis, 9 McMahon, Québec City, QC G1R-2J6, Canada. Amelie.Rodrigue@crchudequebec.ulaval.ca.|Department of Molecular Biology, Medical Biochemistry and Pathology, Centre de Recherche sur le Cancer, Laval University, Québec City, QC G1V-0A6, Canada. Amelie.Rodrigue@crchudequebec.ulaval.ca.
authors.forename: Amélie
authors.initials: A
authors.lastname: Rodrigue
authors.affiliation: Department of Molecular Biology, Medical Biochemistry and Pathology, Centre de Recherche sur le Cancer, Laval University, Québec City, QC G1V-0A6, Canada. guy.poirier@crchul.ulaval.ca.|CHU de Québec Research Center, Oncology Axis, 2705 boul. Laurier, Quebec city, QC G1V-4G2, Canada. guy.poirier@crchul.ulaval.ca.
authors.forename: Guy G
authors.initials: GG
authors.lastname: Poirier
authors.affiliation: DNA repair regulation team, UFIP, CNRS UMR 6286, Université de Nantes, 2 rue de la Houssinière, Nantes 44322, France. fabrice.fleury@univ-nantes.fr.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Fleury
authors.affiliation: Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Axis, 9 McMahon, Québec City, QC G1R-2J6, Canada. Yves.Masson@crchudequebec.ulaval.ca.|Department of Molecular Biology, Medical Biochemistry and Pathology, Centre de Recherche sur le Cancer, Laval University, Québec City, QC G1V-0A6, Canada. Yves.Masson@crchudequebec.ulaval.ca.|CHU de Québec Research Center, Oncology Axis, 2705 boul. Laurier, Quebec city, QC G1V-4G2, Canada. Yves.Masson@crchudequebec.ulaval.ca.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Masson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004249:DNA Damage; D045643:DNA Repair Enzymes / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D045643:DNA Repair Enzymes
keywords: ATM; ATR; CHK1; CHK2; DNA repair; MRE11; PARP; RAD51; inhibitors