title: Fine-Needle Aspiration Biopsy of Salivary Gland Lesions.
abstract: BACKGROUND
  Fine-needle aspiration (FNA) is a well-established diagnostic approach for salivary gland lesions; however, lack of a standard system of terminology for classification of salivary gland neoplasms collected by FNA and the relatively high frequency of uncertainty of diagnosis are likely partly responsible for current confusion in the interpretation of these FNA samples.
  
  
  OBJECTIVE
  To propose a novel classification system for reporting salivary gland FNA samples and summarize recent progress in application of molecular and immunohistochemical markers in selected salivary gland neoplasms.
  
  
  METHODS
  Literature review and authors' personal practice experience.
  
  
  CONCLUSIONS
  The new classification system provides a more succinct, standardized interpretation of results and will ultimately assist in communication between clinicians, clinical decision making, and preoperative patient counseling. Impressive advances have been made in recent years in the understanding of molecular pathogenesis of salivary gland tumors. With the newly acquired diagnostic tools, significant improvement in diagnostic accuracy of salivary gland FNA can certainly be expected.
authors.affiliation: From the Departments of Pathology (Drs Wang, Khurana, and Jhala) and Otolargyngology (Dr Fundakowski), Temple University Hospital, Temple University School of Medicine, Philadelphia, Pennsylvania.
authors.forename: He
authors.initials: H
authors.lastname: Wang
authors.forename: Christopher
authors.initials: C
authors.lastname: Fundakowski
authors.forename: Jasvir S
authors.initials: JS
authors.lastname: Khurana
authors.forename: Nirag
authors.initials: N
authors.lastname: Jhala
mesh_terms: D008949:Adenoma, Pleomorphic / Q000145:classification* / Q000378:metabolism / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism*; D044963:Biopsy, Fine-Needle; D002277:Carcinoma / Q000145:classification* / Q000378:metabolism / Q000473:pathology; D000066491:Clinical Decision-Making; D006801:Humans; D012468:Salivary Gland Neoplasms / Q000145:classification* / Q000378:metabolism / Q000473:pathology; D012469:Salivary Glands / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor