title: Sperm Motility Requires Wnt/GSK3 Stabilization of Proteins.
abstract: Inhibition of GSK3 by Wnt signaling stabilizes many cellular proteins, but proof that this effect is independent of β-catenin-mediated transcription is lacking. Koch, Acebron, and colleagues (2015) now demonstrate that transcriptionally silent mammalian sperm require Wnt signaling via exosomes to prevent protein degradation during their lengthy travels through the epididymis.
authors.affiliation: Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095-1737, USA. Electronic address: ederobertis@mednet.ucla.edu.
authors.forename: Edward M
authors.initials: EM
authors.lastname: De Robertis
authors.affiliation: Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095-1737, USA.
authors.forename: Diego
authors.initials: D
authors.lastname: Ploper
mesh_terms: D000818:Animals; D004822:Epididymis / Q000378:metabolism*; D005786:Gene Expression Regulation; D008297:Male; D013079:Sperm Maturation; D060449:Wnt Signaling Pathway