title: Atypical presentation of multicentric Castleman disease in a pediatric patient: pleural and pericardial effusion.
abstract: Castleman disease (CD) is a rare poorly understood lymphoproliferative disorder. Pediatric onset CD has been reported before. However, most of them have benign unicentric pattern. Multicentric CD (MCD) is quite rare in children. Herein, we report a 13-year-old adolescent boy with MCD of the hyaline vascular variant presenting with pleural and pericardial effusion, which is an uncommon presentation.
  
  
  CONCLUSIONS
  MCD should be considered in the differential diagnosis of pleural and/or pericardial effusion with unexplained lymph nodes in children. What is Known •Pediatric Castleman disease (CD) most commonly occurs in the unicentric form, which typically is asymptomatic and cured by lymph node excision. •The diagnosis of MCD can be difficult owing to the heterogeneity of presentation and potential for nonspecific multisystem involvement. What is New •A 13-year-old adolescent boy was diagnosed with MCD of the hyaline vascular variant presenting with pleural and pericardial effusion, which is an uncommon presentation. •In a pediatric patient with fever, pleural-pericardial effusion and multiple lymph nodes, MCD should be considered in differantial diagnosis.
authors.affiliation: Department of General Pediatrics, Ankara Children's Hematology and Oncology Training Hospital, Ankara, Turkey. alkimakman@gmail.com.|Ankara Çocuk Sağlığı ve Hastalıkları Hematoloji Onkoloji Eğitim Araştırma Hastanesi, İrfan Baştuğ Caddesi Ziraat Mahallesi Altındağ, Ankara, Turkey. alkimakman@gmail.com.
authors.forename: Alkim Oden
authors.initials: AO
authors.lastname: Akman
authors.affiliation: Department of Pediatric Rheumatology, Ankara Children's Hematology and Oncology Training Hospital, Ankara, Turkey.
authors.forename: Ozge
authors.initials: O
authors.lastname: Basaran
authors.affiliation: Department of Pediatric Oncology, Ankara Children's Hematology and Oncology Training Hospital, Ankara, Turkey.
authors.forename: Derya
authors.initials: D
authors.lastname: Ozyoruk
authors.affiliation: Department of Pathology & Cytology, Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
authors.forename: Unsal
authors.initials: U
authors.lastname: Han
authors.affiliation: Department of Pediatric Hematology, Ankara Children's Hematology and Oncology Training Hospital, Ankara, Turkey.
authors.forename: Tulin
authors.initials: T
authors.lastname: Sayli
authors.affiliation: Department of Pediatric Rheumatology, Ankara Children's Hematology and Oncology Training Hospital, Ankara, Turkey.
authors.forename: Nilgun
authors.initials: N
authors.lastname: Cakar
mesh_terms: D000293:Adolescent; D005871:Castleman Disease / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D004452:Echocardiography; D006801:Humans; D008297:Male; D010490:Pericardial Effusion / Q000209:etiology*; D010996:Pleural Effusion / Q000209:etiology*; D011859:Radiography
keywords: Castleman disease; Children; Pericardial effusion; Pleural effusion