title: A multi-scale, multi-disciplinary approach for assessing the technological, economic and environmental performance of bio-based chemicals.
abstract: In recent years, bio-based chemicals have gained interest as a renewable alternative to petrochemicals. However, there is a significant need to assess the technological, biological, economic and environmental feasibility of bio-based chemicals, particularly during the early research phase. Recently, the Multi-scale framework for Sustainable Industrial Chemicals (MuSIC) was introduced to address this issue by integrating modelling approaches at different scales ranging from cellular to ecological scales. This framework can be further extended by incorporating modelling of the petrochemical value chain and the de novo prediction of metabolic pathways connecting existing host metabolism to desirable chemical products. This multi-scale, multi-disciplinary framework for quantitative assessment of bio-based chemicals will play a vital role in supporting engineering, strategy and policy decisions as we progress towards a sustainable chemical industry.
authors.affiliation: Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK-2930 Hørsholm, Denmark.
authors.forename: Markus
authors.initials: M
authors.lastname: Herrgård
authors.affiliation: Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK-2930 Hørsholm, Denmark.
authors.forename: Sumesh
authors.initials: S
authors.lastname: Sukumara
authors.affiliation: Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK-2930 Hørsholm, Denmark.
authors.forename: Miguel
authors.initials: M
authors.lastname: Campodonico
authors.affiliation: Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK-2930 Hørsholm, Denmark kazh@biosustain.dtu.dk.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhuang
mesh_terms: D000818:Animals; D002617:Chemical Industry / Q000191:economics / Q000379:methods*; D003198:Computer Simulation; D003247:Conservation of Natural Resources / Q000191:economics / Q000379:methods*; D017753:Ecosystem; D004736:Energy-Generating Resources / Q000191:economics / Q000706:statistics & numerical data; D006801:Humans; D008962:Models, Theoretical; D011634:Public Health / Q000191:economics / Q000706:statistics & numerical data; D013672:Technology / Q000191:economics / Q000379:methods*
keywords: bio-based chemicals; industrial biotechnology; modelling; multi-disciplinary; multi-scale; sustainability