title: The Use of Adjuvants for Enhancing Allergen Immunotherapy Efficacy.
abstract: One key approach to increase the efficacy and the safety of immunotherapy is the use of adjuvants. However, many of the adjuvants currently in use can cause adverse events, raising concerns regarding their clinical use, and are geared toward productive immune responses but not necessarily tolerogenic responses. Thus, novel adjuvants for immunotherapy are needed and are being developed. Essential is their potential to boost appropriate tolerogenic adaptive immune responses to allergens while limiting side effects. This review provides an overview of adjuvants currently in clinical use or under development and discusses their therapeutic effect in enhancing allergen-induced tolerance.
authors.affiliation: Center of Allergy & Environment (ZAUM), Technical University of Munich and Helmholtz Center, Biedersteiner Street 29, Munich 80802, Germany.
authors.forename: Julie
authors.initials: J
authors.lastname: Chesné
authors.affiliation: Center of Allergy & Environment (ZAUM), Technical University of Munich and Helmholtz Center, Biedersteiner Street 29, Munich 80802, Germany. Electronic address: csweber@tum.de.
authors.forename: Carsten B
authors.initials: CB
authors.lastname: Schmidt-Weber
authors.affiliation: Center of Allergy & Environment (ZAUM), Technical University of Munich and Helmholtz Center, Biedersteiner Street 29, Munich 80802, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Esser von-Bieren
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000485:Allergens / Q000276:immunology; D000818:Animals; D003888:Desensitization, Immunologic; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000628:therapy*; D007108:Immune Tolerance; D056747:Immunomodulation; D058408:Th1-Th2 Balance
chemical_list: D000276:Adjuvants, Immunologic; D000485:Allergens
keywords: Adjuvants; Allergen-specific immunotherapy; Immune tolerance