title: Synthesis, Spectral investigation (¹H, ¹³C) and Anti-microbial Screening of benzophenone imines.
abstract: New series of benzophenone imines with general formula Ph2-C=NR; R = Benzyl, 4-Fluorobenzyl, Naphthyl, Phenyl, 4-Nitrophenyl were synthesized by condensation of dichlorodiphenylmethane and different aromatic primary amines (1:1) Those imines were characterized by different physiochemical and spectroscopic techniques like melting point, elemental analysis, FT-IR, multinuclear NMR (¹H, ¹³C). After characterization, imines were subjected to anti-microbial activities. All compounds showed promising activity against different bacterial strains like Escherichia coli, Bacillussubtilis, Pasturellam ultocida and Staphylococcus aureus as well as fungal strains like Alternata alternaria, Ganoderma lucidium, Penicillium notatum and Trichoderma harzianum using Amoxicillin and Flucanazole as a standard drugs respectively.
authors.affiliation: Departmentof Chemistry Government College University, Faisalabad, Pakistan.
authors.forename: Muhammad Kaleem
authors.initials: MK
authors.lastname: Khosa
authors.affiliation: Departmentof Chemistry Government College University, Faisalabad, Pakistan.
authors.forename: Muhammad Asghar
authors.initials: MA
authors.lastname: Jamal
authors.affiliation: Departmentof Chemistry, Quaid-e-Azam University, Islamabad, Pakistan.
authors.forename: Muhammad Jawad
authors.initials: MJ
authors.lastname: Saif
authors.affiliation: Departmentof Chemistry, Quaid-e-Azam University, Islamabad, Pakistan.
authors.forename: Majid
authors.initials: M
authors.lastname: Muneer
authors.affiliation: Departmentof Chemistry, Quaid-e-Azam University, Islamabad, Pakistan.
authors.forename: Fazalur
authors.initials: F
authors.lastname: Rehman
authors.affiliation: Departmentof Chemistry and Biochemistry University of Agricultural, Faisalabad, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Farman
authors.affiliation: Departmentof Chemistry Government College University, Faisalabad, Pakistan.
authors.forename: Hafiz Muhammad
authors.initials: HM
authors.lastname: Shoaib
authors.affiliation: -
authors.forename: Muhammad
authors.initials: M
authors.lastname: Shahid
authors.affiliation: Departmentof Chemistry Government College University, Faisalabad, Pakistan.
authors.forename: Shabnam
authors.initials: S
authors.lastname: Hameed
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D001577:Benzophenones / Q000138:chemical synthesis* / Q000494:pharmacology*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D052978:Disk Diffusion Antimicrobial Tests; D015725:Fluconazole / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D007097:Imines / Q000138:chemical synthesis* / Q000494:pharmacology*; D066244:Proton Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D044366:Transition Temperature
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D001577:Benzophenones; D007097:Imines; D000658:Amoxicillin; D015725:Fluconazole