title: Telomerase Therapy to Reverse Cardiovascular Senescence.
abstract: Cellular senescence of endothelial cells plays an important role in the development of vascular lesions that ultimately lead to an atherosclerotic plaque. This review focuses on the age-related changes of endothelial and vascular smooth muscle cells that contribute to vascular disease and discusses potential new targets that could rejuvenate the vascular system and thereby prevent or delay atherosclerosis.
authors.affiliation: Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas.
authors.forename: Timo Z
authors.initials: TZ
authors.lastname: Nazari-Shafti
authors.affiliation: Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas.
authors.forename: John P
authors.initials: JP
authors.lastname: Cooke
mesh_terms: D000367:Age Factors; D000818:Animals; D050197:Atherosclerosis / Q000201:enzymology / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D016922:Cellular Senescence; D042783:Endothelial Cells / Q000201:enzymology* / Q000473:pathology; D004730:Endothelium, Vascular / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D004790:Enzyme Induction; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D058226:Plaque, Atherosclerotic; D012038:Regeneration; D015398:Signal Transduction; D019098:Telomerase / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*
chemical_list: D019098:Telomerase
keywords: aging; atherosclerosis; cellular senescence; endothelium; modified MRNA; prevention; telomerase