title: The microcirculatory failure could not weaken the increase of systematic oxygen extraction rate in septic shock: An observational study in canine models.
abstract: OBJECTIVE
  This study aimed at exploring what level of the microcirculation alteration could weaken the decrease of ScvO2 (or the increase of O2ER) and further result in an abnormally elevated ScvO2.
  
  
  METHODS
  Beagles were randomly assigned into control (n = 5) and shock group (n = 5). The canines in shock group were intravenously injected with live E. coli (3.5×108 cfu/kg), and the ones in control group were injected with sterile saline. The experiment continued to the animals' death or for a maximum of 24 hours. Hemodynamic parameters, blood gas and inflammatory cytokines level were collected. Microcirculatory parameters were assessed with Sidestream Dark Field (SDF) imaging. The correlation between the microcirculation and oxygen metabolism or inflammatory cytokine, meanwhile the correlation between the oxygen metabolism and inflammatory cytokine was assessed.
  
  
  RESULTS
  E. coli infusion induced hypodynamic shock. The correlation between microcirculation and oxygen metabolism or inflammatory cytokine, and The correlation between the oxygen metabolism and inflammatory cytokine (O2ER vs. MFI: r = -0.700, P < 0.01; O2ER vs. PVD: r = -0.677, P < 0.01; O2ER vs. PPV: r = -0.538, P < 0.01; MFI vs. IL-6: r = -0.780, P < 0.01; PPV vs. IL-6: r = -0.621, P < 0.01; MFI vs. TNF-α: r = -0.636, P < 0.01; PPV vs. TNF-α: r = -0.561, P < 0.01) were observed.
  
  
  CONCLUSIONS
  The increase of O2ER cannot be weakened by the microcirculatory failure.
authors.forename: Xin
authors.initials: X
authors.lastname: An
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
authors.forename: Yini
authors.initials: Y
authors.lastname: Sun
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Ma
mesh_terms: D000818:Animals; D004285:Dogs; D006439:Hemodynamics; D008833:Microcirculation; D023421:Models, Animal; D010101:Oxygen Consumption / Q000502:physiology*; D012772:Shock, Septic / Q000097:blood*
keywords: Oxygen consumption rate; canine; inflammatory cytokines; microcirculation; septic shock