title: [Vitamin E and Alzheimer's Disease].
abstract: It has been suggested that oxidative stress may contribute to the pathogenesis of Alzheimer's disease. Vitamin E is a potent antioxidant, and the results of some epidemiological studies have suggested that high intake of vitamin E through food is inversely associated with the incidence of Alzheimer's disease. Randomized controlled studies have shown that treatment with vitamin E could delay functional decline in patients with mild to moderate Alzheimer's disease. However, vitamin E had no cognitive benefits in patients with mild cognitive impairment or in generally healthy older women. Well-designed clinical trials or preventive interventions with vitamin E are necessary to establish its efficacy as therapeutic or preventive agents for Alzheimer's disease.
authors.affiliation: Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science.
authors.forename: Moeko
authors.initials: M
authors.lastname: Shinohara
authors.forename: Masahito
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000975:Antioxidants / Q000494:pharmacology*; D060825:Cognitive Dysfunction / Q000188:drug therapy*; D018450:Disease Progression; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology; D014810:Vitamin E / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D014810:Vitamin E