title: Uterine sarcoma vs adenocarcinoma: can MRI distinguish between them?
abstract: OBJECTIVE
  To analyze the MRI characteristics of uterine sarcomas (mainly carcinosarcomas) and to compare them with those of adenocarcinomas to define the findings that would be useful for the differential diagnosis.
  
  
  METHODS
  We retrospectively reviewed the MRI studies of 13 patients with histologically diagnosed uterine sarcoma. We analyzed tumor size, signal in T2-weighted, unenhanced and gadolinium-enhanced T1-weighted, and diffusion-weighted sequences. We compared the data obtained with those of another series of 30 consecutive cases of adenocarcinomas studied with MRI.
  
  
  RESULTS
  The sarcomas (> 9cm in 77% of cases) were considerably larger than the adenocarcinomas (p<0.001). There were no differences in FIGO staging by MRI or surgery: both tumor types were diagnosed in early stages. The signal intensity in T2-weighted images differed significantly between the two tumor types: all the sarcomas were heterogeneous and predominantly hyperintense with respect to the myometrium in T2-weighted sequences (p<0.001). In postcontrast studies, all the sarcomas showed enhancement greater than or equal to the myometrium; this finding was significantly different from the adenocarcinomas (p<0.001). In diffusion-weighted sequences, we found no significant differences in ADC values in the areas with greatest restriction, but the ADC map was more heterogeneous in the sarcomas.
  
  
  CONCLUSIONS
  Uterine sarcomas do not have specific characteristics on MRI, but some findings can indicate the diagnosis. In our study, we found significant differences between sarcomas and adenocarcinomas. Sarcomas were larger, had more hyperintense and heterogeneous signal intensity in T2-weighted sequences, and enhanced more than or at least as much as the myometrium.
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Clínico San Carlos, Madrid, España. Electronic address: phmaula@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Hernández Mateo
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Clínico San Carlos, Madrid, España.
authors.forename: R
authors.initials: R
authors.lastname: Méndez Fernández
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Clínico San Carlos, Madrid, España.
authors.forename: E
authors.initials: E
authors.lastname: Serrano Tamayo
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012189:Retrospective Studies; D012509:Sarcoma / Q000000981:diagnostic imaging*; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging*
keywords: Adenocarcinoma; Carcinosarcoma; Magnetic resonance imaging; Resonancia magnética; Sarcoma; Uterus; Útero