title: Echocardiographic Evaluation of Biventricular Function in Patients with Euthyroid Hashimoto's Thyroiditis.
abstract: OBJECTIVE
  The aim of this study was to evaluate the left (LV) and right (RV) ventricular function in euthyroid Hashimoto's thyroiditis (eHT) patients.
  
  
  METHODS
  Forty-five patients diagnosed with eHT and 45 age- and gender-matched control subjects were enrolled in this study. Echocardiographic parameters reflecting RV and LV functions such as chamber dimensions, ejection fraction, fractional shortening, conventional and tissue Doppler-derived early and late filling velocities (E, A, E', A'), isovolumic relaxation (IVRT) and contraction (IVCT) times, ejection time (ET), deceleration time (DT), Tei index, pulmonary acceleration time (PAcT) and tricuspid annular plane systolic excursion (TAPSE) of patients with eHT were compared to those of control subjects using the paired-samples t test or Wilcoxon signed-rank test.
  
  
  RESULTS
  Regarding the LV function, compared to the controls patients with eHT had a higher LV-Tei index (0.6 ± 0.2 vs. 0.4 ± 0.1, p < 0.001), higher DT (p < 0.001) and IVRT (p < 0.001) values, and higher E/E' ratios (p = 0.04). In contrast, the peak E wave velocity (p = 0.02), E/A ratio (p = 0.01) and ET (p = 0.02) were significantly lower in the eHT group than amongst the controls. The RV, Tei index (0.40 ± 0.11 vs. 0.28 ± 0.07, p < 0.001), TAPSE (2.0 ± 0.3 vs. 2.2 ± 0.2 mm, p < 0.001), PAcT (124.3 ± 22.6 vs. 149.4 ± 18.3 ms, p < 0.001), A' (p = 0.007) and IVCT (p = 0.001) were significantly higher in patients with eHT than the controls. However, the tricuspid E/A ratio (p = 0.01), E' (p = 0.03) and E'/A' ratio (p = 0.001) were significantly lower in the eHT patients than the control group.
  
  
  CONCLUSIONS
  This study demonstrated that both RV and LV functions were impaired in patients with eHT.
authors.affiliation: Department of Cardiology, Sakarya University Training and Research Hospital, Sakarya, Turkey.
authors.forename: Mehmet Bülent
authors.initials: MB
authors.lastname: Vatan
authors.forename: Ceyhun
authors.initials: C
authors.lastname: Varım
authors.forename: Mustafa Tarık
authors.initials: MT
authors.lastname: Ağaç
authors.forename: Perihan
authors.initials: P
authors.lastname: Varım
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Çakar
authors.forename: Murat
authors.initials: M
authors.lastname: Aksoy
authors.forename: Hakan
authors.initials: H
authors.lastname: Erkan
authors.forename: Sabiye
authors.initials: S
authors.lastname: Yılmaz
authors.forename: Harun
authors.initials: H
authors.lastname: Kilic
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Gündüz
authors.forename: Ramazan
authors.initials: R
authors.lastname: Akdemir
mesh_terms: D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D050031:Hashimoto Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014261:Tricuspid Valve / Q000000981:diagnostic imaging* / Q000473:pathology; D018754:Ventricular Dysfunction / Q000000981:diagnostic imaging*; D016277:Ventricular Function, Left