title: Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis.
abstract: Although a number of studies have reported that human leukocyte antigen (HLA)-DRB1 alleles may be correlated with tuberculosis (TB), most were based on small samples or inconsistent and unclear results. Here, we present a meta-analysis to investigate the relationship between HLA-DRB1 alleles and TB susceptibility. We gathered relevant information from published studies on the association between HLA‑DRB1 alleles and TB susceptibility through a systematic research. Data from eligible fifteen studies were included in the meta-analyses. Each dataset was statistically analyzed to evaluate the HLA‑DRB1 alleles by calculating the respective odds ratios (ORs) and 95% confidence intervals (CIs). The results revealed that frequencies of two DRB1 alleles were significantly decreased in TB: DRB1*03 (P = 0.016, OR = 0.78, 95%CI = 0.67‑0.95) and DRB1*07 (P = 0.017, OR = 0.81, 95%CI = 0.68‑0.96). Thus, our data indicate that DRB1*03 and DRB1*07 may provide protective effects against TB susceptibility. However, well‑designed studies with large sample sizes are required for better understanding of this association.
authors.affiliation: School of Public Health, Wannan Medical College, Wuhu, China.
authors.forename: B F
authors.initials: BF
authors.lastname: Chen
authors.affiliation: Department of Health Inspection and Supervision, Wuhu Health Bureau, Wuhu, China.
authors.forename: R
authors.initials: R
authors.lastname: Wang
authors.affiliation: School of Public Health, Wannan Medical College, Wuhu, China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Chen
authors.affiliation: School of Public Health, Wannan Medical College, Wuhu, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: School of Public Health, Wannan Medical College, Wuhu, China.
authors.forename: L
authors.initials: L
authors.lastname: Ding
authors.affiliation: School of Public Health, Wannan Medical College, Wuhu, China wyf@wnmc.edu.cn.
authors.forename: Y F
authors.initials: YF
authors.lastname: Wen
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017594:Publication Bias; D014376:Tuberculosis / Q000235:genetics* / Q000382:microbiology
chemical_list: D059811:HLA-DRB1 Chains