title: Application of albumin-based nanoparticles in the management of cancer.
abstract: Over the past three decades, tremendous progress has been made in cancer prevention and treatment. Despite these advances, a substantial number of cancer cases experience early recurrence and metastases. Thus, the better management of cancer, especially developing more effective drugs for combating cancer cells, is an arduous task. Albumin-based nanoparticles are emerging as a promising approach to replace the traditional way of carrying therapeutic drugs to a tumor site. In this review, we describe the basic knowledge on albumin-based nanoparticles, recent progress of using albumin-based nanoparticles in the diagnosis and treatment of cancer, and the application of nanoparticle albumin bound (Nab) paclitaxel for the treatment of lung, breast and pancreatic cancer. Last but not least, we try to discuss future goals and perspectives in the field of drug delivery research, thereby facilitating the antitumor activity.
authors.affiliation: Department of Pancreatic Surgery, Huashan Hospital, Fudan University, Middle Urumqi Road 12#, Shanghai, 200040, China. yuxinzhe1@me.com.
authors.forename: Xinzhe
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Pancreatic Surgery, Huashan Hospital, Fudan University, Middle Urumqi Road 12#, Shanghai, 200040, China. galleyking@hotmail.com.
authors.forename: Chen
authors.initials: C
authors.lastname: Jin
mesh_terms: D000418:Albumins / Q000627:therapeutic use*; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000418:Albumins