title: Translational research in nephrology: chronic kidney disease prevention and public health.
abstract: This narrative review evaluates translational research with respect to five important risk factors for chronic kidney disease (CKD): physical inactivity, high salt intake, smoking, diabetes and hypertension. We discuss the translational research around prevention of CKD and its complications both at the level of the general population, and at the level of those at high risk, i.e. people at increased risk for CKD or CKD complications. At the population level, all three lifestyle risk factors (physical inactivity, high salt intake and smoking) have been translated into implemented measures and clear population health improvements have been observed. At the 'high-risk' level, the lifestyle studies reviewed have tended to focus on the individual impact of specific interventions, and their wider implementation and impact on CKD practice are more difficult to establish. The treatment of both diabetes and hypertension appears to have improved, however the impact on CKD and CKD complications was not always clear. Future studies need to investigate the most effective translational interventions in low and middle income countries.
authors.affiliation: ERA-EDTA Registry , Department of Medical Informatics, Academic Medical Center - University of Amsterdam , Amsterdam , The Netherlands.
authors.forename: Katharina
authors.initials: K
authors.lastname: Brück
authors.affiliation: ERA-EDTA Registry , Department of Medical Informatics, Academic Medical Center - University of Amsterdam , Amsterdam , The Netherlands.
authors.forename: Vianda S
authors.initials: VS
authors.lastname: Stel
authors.affiliation: Academic Unit of Primary Care and Population Sciences , University of Southampton , Southampton , UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Fraser
authors.affiliation: Department of Public Health , Academic Medical Center (AMC) - University of Amsterdam , Amsterdam , The Netherlands.
authors.forename: Moniek C M
authors.initials: MC
authors.lastname: De Goeij
authors.affiliation: Renal Unit , Southmead Hospital , Bristol , UK.
authors.forename: Fergus
authors.initials: F
authors.lastname: Caskey
authors.affiliation: Department of Medical Informatics , Academic Medical Center - University of Amsterdam , Amsterdam , The Netherlands.
authors.forename: Ameen
authors.initials: A
authors.lastname: Abu-Hanna
authors.affiliation: ERA-EDTA Registry , Department of Medical Informatics, Academic Medical Center - University of Amsterdam , Amsterdam , The Netherlands.
authors.forename: Kitty J
authors.initials: KJ
authors.lastname: Jager
keywords: CKD; diabetes mellitus; epidemiology; hypertension; physical activity