title: Management of bile acid malabsorption using low-fat dietary interventions: a useful strategy applicable to some patients with diarrhoea-predominant irritable bowel syndrome?
abstract: This study evaluates the efficacy of low-fat dietary interventions in the management of gastrointestinal (GI) symptoms due to bile acid malabsorption. In total, 40 patients with GI symptoms and a 7-day (75)selenium homocholic acid taurine (SeHCAT) scan result of <20%, were prospectively recruited and then advised regarding a low-fat dietary intervention. Before and after dietary intervention, patients rated their GI symptoms using a 10-point numerical scale, and recorded their intake in 7-day dietary diaries. After dietary intervention, the median scores for all GI symptoms decreased, with a significant reduction for urgency, bloating, lack of control, bowel frequency (p ≥: 0.01). Mean dietary fat intake reduced to 42 g fat after intervention (p ≥: 0.01). Low-fat dietary interventions in patients with a SeHCAT scan result of <20% leads to clinically important improvement in GI symptoms and should be widely used.
authors.affiliation: Department of Nutrition and Dietetics, The Royal Marsden NHS Foundation Trust, London, UK.
authors.forename: Lorraine
authors.initials: L
authors.lastname: Watson
authors.affiliation: GI Unit, Department of Medicine, The Royal Marsden NHS Foundation Trust, London, UK.
authors.forename: Amyn
authors.initials: A
authors.lastname: Lalji
authors.affiliation: Department of Statistics, The Royal Marsden NHS Foundation Trust, Sutton, UK.
authors.forename: Shankar
authors.initials: S
authors.lastname: Bodla
authors.affiliation: GI Unit, Department of Medicine, The Royal Marsden NHS Foundation Trust, London, UK.
authors.forename: Ann
authors.initials: A
authors.lastname: Muls
authors.affiliation: GI Unit, Department of Medicine, The Royal Marsden NHS Foundation Trust, London, UK.
authors.forename: H Jervoise N
authors.initials: HJ
authors.lastname: Andreyev
authors.affiliation: Department of Nutrition and Dietetics, The Royal Marsden NHS Foundation Trust, Fulham Road, London, UK clare.shaw@rmh.nhs.uk.
authors.forename: Clare
authors.initials: C
authors.lastname: Shaw
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001647:Bile Acids and Salts / Q000378:metabolism*; D003967:Diarrhea / Q000150:complications / Q000178:diet therapy*; D018752:Diet, Fat-Restricted; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D045602:Steatorrhea / Q000150:complications / Q000178:diet therapy*; D013656:Taurocholic Acid / Q000031:analogs & derivatives; D055815:Young Adult
chemical_list: D001647:Bile Acids and Salts; D013656:Taurocholic Acid; C033638:23-seleno-25-homotaurocholic acid
keywords: Bile acid malabsorption; SeHCAT; low-fat diet