title: Influence of paternal age on ongoing pregnancy rate at eight weeks' gestation in assisted reproduction.
abstract: A retrospective cohort study was performed with the followings aims: to evaluate the influence of paternal age on best embryo quality available for embryo transfer on the third day; biochemical pregnancy rate; miscarriage rate and ongoing pregnancy rate at 8 weeks' gestational age, after IVF or intracytoplasmic sperm injection (ICSI) treatment, respectively, including treatment with non-ejaculated spermatozoa. In total, 7051 first IVF/ICSI cycles in Radboud university medical center, between 1 January 2001 and 1 June 2013 were included in this study. A statistical model was used to analyse the effect of paternal age and maternal age. No statistically significant differences between the paternal age groups were found with respect to the probability of an ongoing pregnancy after the first cycle (35-44 years: odds ratio [OR] = 0.97 [95% confidence interval [CI]: 0.86 to 1.10] and ≥45 years: OR = 1.01 [95% CI: 0.82 to 1.26]), respectively, compared with <35 years of age (control). Similar results were found with respect to paternal age and the availability of a top quality embryo for transfer, biochemical pregnancy and miscarriage. However, live birth was not taken into account. In conclusion, paternal age did not affect ongoing pregnancy rates in first IVF/ICSI cycles.
authors.affiliation: Department of Obstetrics and Gynaecology, Division of Reproductive Medicine, Radboud university medical center, P.O. Box 9101, 6500 HB Nijmegen, Netherlands. Electronic address: aukje.meijerink@radboudumc.nl.
authors.forename: Aukje Marieke
authors.initials: AM
authors.lastname: Meijerink
authors.affiliation: Department of Obstetrics and Gynaecology, Division of Reproductive Medicine, Radboud university medical center, P.O. Box 9101, 6500 HB Nijmegen, Netherlands.
authors.forename: Liliana
authors.initials: L
authors.lastname: Ramos
authors.affiliation: Department of Obstetrics and Gynaecology, Division of Reproductive Medicine, Radboud university medical center, P.O. Box 9101, 6500 HB Nijmegen, Netherlands.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Fleischer
authors.affiliation: Department of Human Genetics, Radboud university medical center, P.O. Box 9101, 6500 HB Nijmegen, Netherlands.
authors.forename: Joris A
authors.initials: JA
authors.lastname: Veltman
authors.affiliation: Radboud Institute for Health Science, Radboud university medical center, P.O. Box 9101, 6500 HB Nijmegen, Netherlands.
authors.forename: Jan C
authors.initials: JC
authors.lastname: Hendriks
authors.affiliation: Department of Obstetrics and Gynaecology, Division of Reproductive Medicine, Radboud university medical center, P.O. Box 9101, 6500 HB Nijmegen, Netherlands.
authors.forename: Didi D
authors.initials: DD
authors.lastname: Braat
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000453:epidemiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010331:Paternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D018873:Pregnancy Rate; D011261:Pregnancy Trimester, First; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D055815:Young Adult
keywords: assisted reproductive techniques; male infertility; paternal age; pregnancy rate; semen; spermatozoa