title: Carapanolides T-X from Carapa guianensis (Andiroba) Seeds.
abstract: Two new mexicanolide-type limonoids, carapanolides T-U (1-2), and three new phragmalin-type limonoids, carapanolides V-X (3-5), were isolated from the seeds of Carapa guianensis (andiroba). Their structures were determined on the basis of 1D- and 2D-NMR spectroscopy.
authors.affiliation: Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. teppei-727@ezweb.ne.jp.
authors.forename: Teppei
authors.initials: T
authors.lastname: Miyake
authors.affiliation: Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. saridon55@yahoo.co.jp.
authors.forename: Sari
authors.initials: S
authors.lastname: Ishimoto
authors.affiliation: Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. mini-mini.naoko@hotmail.co.jp.
authors.forename: Naoko
authors.initials: N
authors.lastname: Ishimatsu
authors.affiliation: Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. rikiaifuni815@yahoo.co.jp.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Higuchi
authors.affiliation: Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. minoura@gly.oups.ac.jp.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Minoura
authors.affiliation: Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. t.kikuchi@gly.oups.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kikuchi
authors.affiliation: Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. yamada@gly.oups.ac.jp.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.affiliation: Laboratory of Pharmaceutical Organic Chemistry, Faculty of Pharmacy Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan. muraoka@phar.kindai.ac.jp.
authors.forename: Osamu
authors.initials: O
authors.lastname: Muraoka
authors.affiliation: Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. tanakar@gly.oups.ac.jp.
authors.forename: Reiko
authors.initials: R
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D020128:Inhibitory Concentration 50; D036701:Limonins / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D012639:Seeds / Q000737:chemistry*
chemical_list: D036701:Limonins; D009569:Nitric Oxide
keywords: Carapa guianensis; Meliaceae; NO production; andiroba; limonoid; mexicanolide; phragmalin; seeds