title: Associated factors of radiation pneumonitis induced by precise radiotherapy in 186 elderly patients with esophageal cancer.
abstract: BACKGROUND
  Radiation pneumonitis is one of the most severe complications of esophageal cancer.
  
  
  OBJECTIVE
  To explore the factors correlated to radiation pneumonitis induced by precise radiotherapy for elderly patients with esophageal cancer.
  
  
  METHODS
  The retrospective analysis was used to collect clinical data from 186 elderly patients with esophageal cancer. The incidence of radiation pneumonitis was observed, followed by statistical analysis through ANVON or multiple regression analysis.
  
  
  RESULTS
  27 in 186 cases of esophageal cancer suffered from radiation pneumonitis, with incidence of 14.52%. The single factor analysis showed that, Karnofsky performance status (KPS) score, chronic obstructive pulmonary disease, concurrent chemoradiotherapy, gross tumor volume (GTV) dose, lung V20, mean lung dose (MLD) and planning target volume (PTV) were associated with radiation pneumonitis. The logistic regression analysis indicated that, concurrent chemoradiotherapy, GTV dose, lung V20 and PTV were the independent factors of radiation pneumonitis.
  
  
  CONCLUSIONS
  The concurrent chemoradiotherapy, GTV dose, lung V20, MLD and PTV are the major risk factors of radiation pneumonitis for elderly patients with esophageal cancer.
authors.affiliation: Deptment of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University Suzhou 215000, China ; Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical College Bengbu 233004, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cui
authors.affiliation: Deptment of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University Suzhou 215000, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical College Bengbu 233004, China.
authors.forename: Bin
authors.initials: B
authors.lastname: He
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical College Bengbu 233004, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical College Bengbu 233004, China.
authors.forename: Duojie
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical College Bengbu 233004, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical College Bengbu 233004, China.
authors.forename: Hanfei
authors.initials: H
authors.lastname: Cai
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical College Bengbu 233004, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Lou
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical College Bengbu 233004, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical College Bengbu 233004, China.
authors.forename: Xueming
authors.initials: X
authors.lastname: Shen
authors.affiliation: Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical College Bengbu 233004, China.
authors.forename: Kaigui
authors.initials: K
authors.lastname: Peng
keywords: Elderly; esophageal tumor; factors; precise radiotherapy; radiation pneumonitis