title: SCFAs Take a Toll En Route to Metabolic Syndrome.
abstract: Gut dysbiosis is associated with development of metabolic syndrome in Tlr5(-/-) mice, but the underlying mechanism remains unclear. In this issue, Singh et al. (2015) report that augmented SCFA levels play a deleterious role in metabolic syndrome by promoting conversion of SFA to oleate in Tlr5(-/-) mice via increased liver SCD1expression.
authors.affiliation: Department of Medicine, Quebec Heart and Lung Institute (Laval Hospital), Laval University, Québec, G1V 0A6, Canada; Institute of Nutrition and Functional Foods, Laval University, Québec, G1V 0A6, Canada. Electronic address: andre.marette@criucpq.ulaval.ca.
authors.forename: André
authors.initials: A
authors.lastname: Marette
authors.affiliation: Department of Medicine, University of Florida, Gainesville, FL 32611, USA; Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL 32611, USA. Electronic address: christian.jobin@medicine.ufl.edu.
authors.forename: Christian
authors.initials: C
authors.lastname: Jobin
mesh_terms: D000818:Animals; D008099:Liver / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000378:metabolism*