title: Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma.
abstract: This study aims to investigate the expression of macrophage inflammatory protein-3 alpha (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) and their association with clinical characteristics and prognosis. Primary tumor specimens from 114 NPC patients and associated clinical follow-up data were collected, and the expression of MIP-3α and cystatin A proteins was investigated by immunohistochemistry. Expression of MIP-3α was significantly associated with TNM stage in patients with NPC (P < 0.05). NPC patients with positive expression of MIP-3α exhibited shorter median overall survival (OS) and distant metastasis-free survival (DMFS), compared with patients with negative expression (OS: 50.5 months versus 59.0 months, P = 0.013; DMFS: 50.1 months versus 60.2 months, P = 0.003). NPC patients with positive expression of cystatin A exhibited shorter median OS, local recurrence-free survival (LRFS), and DMFS, compared with patients with negative expression (OS: 51.1 months versus 60.0 months, P = 0.004; LRFS: 54.5 months versus 59.5 months, P = 0.036; DMFS: 52.3 months versus 58.8 months, P = 0.036). Both MIP-3α and cystatin A overexpressions in NPC tumor tissues were strong independent factors of poor prognosis in NPC patients. MIP-3α and cystatin A expressions may be valuable prognostic markers in NPC patients.
authors.affiliation: Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, Guangxi 543002, China ; Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
authors.forename: Minzhong
authors.initials: M
authors.lastname: Tang
authors.affiliation: Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
authors.forename: Ningjiang
authors.initials: N
authors.lastname: Ou
authors.affiliation: Department of Pathology, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Li
authors.affiliation: Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, Guangxi 543002, China ; Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
authors.forename: Aiying
authors.initials: A
authors.lastname: Lu
authors.affiliation: Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, Guangxi 543002, China ; Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pathology, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Radiation Oncology, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhong
authors.affiliation: Department of Radiation Oncology, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
authors.forename: Jianquan
authors.initials: J
authors.lastname: Gao
authors.affiliation: Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, Guangxi 543002, China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, Guangxi 543002, China ; Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
authors.forename: Yonglin
authors.initials: Y
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002277:Carcinoma; D054418:Chemokine CCL20 / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D055312:Cystatin A / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000532:radiotherapy; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; C108355:CCL20 protein, human; D054418:Chemokine CCL20; D055312:Cystatin A; C026407:CSTA protein, human