title: The poor recovery of neuromyelitis optica spectrum disorder is associated with a lower level of CXCL12 in the human brain.
abstract: Neuromyelitis optica spectrum disorders (NMOSDs) are blindness-causing neuritis. In NMOSD patients, NMO-IgG evokes astrocytopathy that in turn causes demyelination. While measurement of NMO-IgG titer will help neurologists make the diagnosis of NMOSDs, it is not sufficient to evaluate the severity of astrocytopathy. In this study, we compared the different levels of an astrocyte biomarker in cerebrospinal fluid of NMOSD patients with good or poor recovery, and then linked their differences to the changes in remyelinating promoter (CXCL12) levels. Our results indicate that NMO-IgG down-regulated CXCL12 and impaired the remyelinating process, this may be a mechanism contributing to the poor recovery of NMOSDs.
authors.affiliation: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Kang
authors.affiliation: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Cao
authors.affiliation: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Tingjun
authors.initials: T
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China; Department of Ophthalmology, Longfu Hospital, Beijing, China.
authors.forename: Zhaocai
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China; Department of Ophthalmology, Dongzhimen Hospital, Beijing, China.
authors.forename: Zihao
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Li
authors.affiliation: Bioori Translational Medicine Center, Beijing, China.
authors.forename: Yangang
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Bioori Translational Medicine Center, Beijing, China.
authors.forename: Nanping
authors.initials: N
authors.lastname: Ai
authors.affiliation: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Quangang
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Psychology, College of Science, University of Texas at Arlington, Arlington, TX, USA. Electronic address: qilin@uta.edu.
authors.forename: Qing
authors.initials: Q
authors.lastname: Lin
authors.affiliation: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China. Electronic address: weishihui706@hotmail.com.
authors.forename: Shihui
authors.initials: S
authors.lastname: Wei
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D051401:Aquaporin 4 / Q000276:immunology; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D054377:Chemokine CXCL12 / Q000378:metabolism*; D004569:Electroencephalography; D004596:Electroretinography; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D010775:Photic Stimulation; D020127:Recovery of Function; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014792:Visual Acuity / Q000502:physiology
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D005904:Glial Fibrillary Acidic Protein; D007074:Immunoglobulin G; D014409:Tumor Necrosis Factor-alpha
keywords: Aquaporin 4 (AQP4); CXC-motif ligand 12 (CXCL12); Glial fibrillary acidic protein (GFAP); Neuromyelitis optica spectrum disorders (NMOSDs); Tumor necrosis factor α (TNFα)