title: Morphologic Updates in Prostate Pathology.
abstract: In the past several years, modifications have been made to the original Gleason system with resultant therapeutic and prognostic implications. Several morphologic variants of prostatic adenocarcinoma have also been described. Prostate pathology has also evolved over the years with the discovery and utility of new immunohistochemical stains. The topics discussed in this update include the Gleason grading system, prognostic grade grouping, variants of prostatic adenocarcinoma, and the application of immunohistochemistry to prostate pathology.
authors.affiliation: Department of Pathology, Yale University School of Medicine, 310 Cedar Street, LH 108, New Haven, CT 06520, USA. Electronic address: adebowale.adeniran@yale.edu.
authors.forename: Adebowale J
authors.initials: AJ
authors.lastname: Adeniran
authors.affiliation: Department of Pathology, Yale University School of Medicine, 310 Cedar Street, LH 108, New Haven, CT 06520, USA.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Humphrey
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D006801:Humans; D008134:Long-Term Care / Q000379:methods; D008297:Male; D060787:Neoplasm Grading; D011159:Population Surveillance / Q000379:methods; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000473:pathology*; D057832:Watchful Waiting / Q000379:methods
keywords: Active surveillance; Gleason system; Immunohistochemistry; Prostatic adenocarcinoma