title: Ventral Subiculum Stimulation Promotes Persistent Hyperactivity of Dopamine Neurons and Facilitates Behavioral Effects of Cocaine.
abstract: The ventral subiculum (vSUB) plays a key role in addiction, and identifying the neuronal circuits and synaptic mechanisms by which vSUB alters the excitability of dopamine neurons is a necessary step to understand the motor changes induced by cocaine. Here, we report that high-frequency stimulation of the vSUB (HFSvSUB) over-activates ventral tegmental area (VTA) dopamine neurons in vivo and triggers long-lasting modifications of synaptic transmission measured ex vivo. This potentiation is caused by NMDA-dependent plastic changes occurring in the bed nucleus of the stria terminalis (BNST). Finally, we report that the modification of the BNST-VTA neural circuits induced by HFSvSUB potentiates locomotor activity induced by a sub-threshold dose of cocaine. Our findings unravel a neuronal circuit encoding behavioral effects of cocaine in rats and highlight the importance of adaptive modifications in the BNST, a structure that influences motivated behavior as well as maladaptive behaviors associated with addiction.
authors.affiliation: Université de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR5297, 33076 Bordeaux, France; Centre National de la Recherche Scientifique, Interdisciplinary Institute for Neuroscience, UMR 5297, 33076 Bordeaux, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Glangetas
authors.affiliation: Université de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR5297, 33076 Bordeaux, France; Centre National de la Recherche Scientifique, Interdisciplinary Institute for Neuroscience, UMR 5297, 33076 Bordeaux, France.
authors.forename: Giulia R
authors.initials: GR
authors.lastname: Fois
authors.affiliation: Université de la Méditerranée, UMR S901, Aix-Marseille 2, 13009 Marseille, France; INSERM-INMED, UMR 901, 13009 Marseille, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Jalabert
authors.affiliation: Institut du Fer a Moulin, 75005 Paris, France; INSERM/UPMC, UMR-S 839, 75005 Paris, France.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Lecca
authors.affiliation: Institut du Fer a Moulin, 75005 Paris, France; INSERM/UPMC, UMR-S 839, 75005 Paris, France.
authors.forename: Kristina
authors.initials: K
authors.lastname: Valentinova
authors.affiliation: Institut du Fer a Moulin, 75005 Paris, France; INSERM/UPMC, UMR-S 839, 75005 Paris, France.
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Meye
authors.affiliation: "G. Minardi" Cognitive Neuroscience Laboratory, Department of Chemistry and Pharmacy, University of Sassari, 07100 Sassari, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Diana
authors.affiliation: CNRS, UMR8246 NPS, 75005 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UM119, NPS, 75005 Paris, France; INSERM, U1130 NPS, 75005 Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Faure
authors.affiliation: Institut du Fer a Moulin, 75005 Paris, France; INSERM/UPMC, UMR-S 839, 75005 Paris, France.
authors.forename: Manuel
authors.initials: M
authors.lastname: Mameli
authors.affiliation: Université de Bordeaux, INCIA, BP31, 33076 Bordeaux, France; CNRS, UMR5287 INCIA, 33076 Bordeaux, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Caille
authors.affiliation: Université de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR5297, 33076 Bordeaux, France; Centre National de la Recherche Scientifique, Interdisciplinary Institute for Neuroscience, UMR 5297, 33076 Bordeaux, France. Electronic address: francois.georges@u-bordeaux.fr.
authors.forename: François
authors.initials: F
authors.lastname: Georges
mesh_terms: D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000503:physiopathology; D004195:Disease Models, Animal; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D059290:Dopaminergic Neurons / Q000187:drug effects* / Q000502:physiology; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007150:Immunohistochemistry; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D018408:Patch-Clamp Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
chemical_list: D018765:Dopamine Uptake Inhibitors; D003042:Cocaine