title: Copper-catalyzed, hypervalent iodine mediated C=C bond activation of enaminones for the synthesis of α-keto amides.
abstract: An unprecedented C=C bond cleavage of enaminones has been realized by means of copper catalysis in the presence of hypervalent iodine (PhI(OAc)2). The cascade transformation based on this bond cleavage leads to the synthesis of various α-keto amides. Isotope labeling experiments suggest that water has acted as a source of oxygen atoms during the generation of the new carbonyl group.
authors.affiliation: College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China. wanjieping@jxnu.edu.cn.
authors.forename: Jie-Ping
authors.initials: JP
authors.lastname: Wan
authors.affiliation: College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China. wanjieping@jxnu.edu.cn.
authors.forename: Yunfang
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Research Centre of Analysis and Measurement, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou, Zhejiang 310014, P. R. China.
authors.forename: Xiaoji
authors.initials: X
authors.lastname: Cao
authors.affiliation: College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China. wanjieping@jxnu.edu.cn.
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China. wanjieping@jxnu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Wei