title: Double filtration plasmapheresis in a dog with multiple myeloma and hyperviscosity syndrome.
abstract: A 12 year old, 38 kg, mix-breed, intact male dog presented with a 20 day history of clinical signs consistent with hyperviscosity syndrome secondary to multiple myeloma. The dog received three double filtration plasmapheresis treatments on day 0, 7 and 22 after presentation. A significant (p<0.05) reduction in serum total protein, alpha-2 and gamma globulins was found following each treatment. These reductions were accompanied by a complete resolution, although temporary, of the clinical signs of hyperviscosity syndrome. The present study reported for the first time the use of double filtration plasmapheresis to reduce clinical signs of hyperviscosity syndrome in a dog with multiple myeloma.
authors.affiliation: UC Veterinary Medical Center San Diego 10435 Sorrento Valley Rd, Suite 101, San Diego, CA 92121, USA.
authors.forename: I
authors.initials: I
authors.lastname: Lippi
authors.affiliation: Dipartimento di Scienze Veterinarie, Università di Pisa, Via Livornese lato monte, 56122 San Piero a Grado (PI), Italy.
authors.forename: F
authors.initials: F
authors.lastname: Perondi
authors.affiliation: UC Veterinary Medical Center San Diego 10435 Sorrento Valley Rd, Suite 101, San Diego, CA 92121, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Ross
authors.affiliation: Dipartimento di Scienze Veterinarie, Università di Pisa, Via Livornese lato monte, 56122 San Piero a Grado (PI), Italy.
authors.forename: V
authors.initials: V
authors.lastname: Marchetti
authors.affiliation: Dipartimento di Scienze Veterinarie, Università di Pisa, Via Livornese lato monte, 56122 San Piero a Grado (PI), Italy.
authors.forename: G
authors.initials: G
authors.lastname: Lubas
authors.affiliation: Dipartimento di Scienze Veterinarie, Università di Pisa, Via Livornese lato monte, 56122 San Piero a Grado (PI), Italy.
authors.forename: G
authors.initials: G
authors.lastname: Guidi
keywords: Apheresis; Dog; Double filtration; Hyperviscosity syndrome; Multiple myeloma