title: New Glabretal Triterpenes from the Immature Fruits of Poncirus trifoliata and Their Selective Cytotoxicity.
abstract: Two new glabretal triterpenes, pancastatins A (1) and B (2), were isolated from the immature fruits of Poncirus trifoliata. Their chemical structures were elucidated by spectroscopic analyses including one- and two-dimensional NMR and high-resolution electrospray ionization mass spectrometry. Compounds 1 and 2 exhibited selective cytotoxicity against PANC-1 pancreatic cancer cells under low-glucose stress conditions.
authors.affiliation: Department of Food Science and Biotechnology, Kyungnam University.
authors.forename: Ae-Ran
authors.initials: AR
authors.lastname: Choi
authors.forename: In-Kyoung
authors.initials: IK
authors.lastname: Lee
authors.forename: E-Eum
authors.initials: EE
authors.lastname: Woo
authors.forename: Jin-Won
authors.initials: JW
authors.lastname: Kwon
authors.forename: Bong-Sik
authors.initials: BS
authors.lastname: Yun
authors.forename: Hae-Ryong
authors.initials: HR
authors.lastname: Park
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008968:Molecular Conformation; D018384:Oxidative Stress; D032104:Poncirus / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C000608936:pancastatin A; C000608937:pancastatin B; D005947:Glucose