title: New 2-Benzoxazolinone Derivatives with Cytotoxic Activities from the Roots of Acanthus ilicifolius.
abstract: Four new 2-benzoxazolinone-type alkaloids (acanthosides A-D) along with three known ones were isolated from the roots of Acanthus ilicifolius. Their structures were established by detailed interpretation of one dimensional (1D)- and two dimensional (2D)-NMR as well as high-resolution electrospray ionization (ESI)-MS data. The antiproliferative activities of these compounds were evaluated in vitro against three cultured cancer cell lines. The new compounds exhibited different levels of cytotoxicity against the HepG2, HeLa, and A-549 cancer cell lines with IC50 range 7.8-26.6 µM. In comparison with known compounds, the new isolates displayed better cytotoxic activities, which was attributable to the presence of substituted benzoyl moiety in their structures.
authors.affiliation: School of Pharmaceutical Science, Hainan Medical University.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhao
authors.forename: Lijun
authors.initials: L
authors.lastname: Xie
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.forename: Ni
authors.initials: N
authors.lastname: An
authors.forename: Wei
authors.initials: W
authors.lastname: Na
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Youbin
authors.initials: Y
authors.lastname: Li
authors.forename: Yinfeng
authors.initials: Y
authors.lastname: Tan
authors.forename: Xiaopo
authors.initials: X
authors.lastname: Zhang
mesh_terms: D027901:Acanthaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001583:Benzoxazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001583:Benzoxazoles; C017057:benzoxazolone