title: Association between interleukin 8 -251 A/T and +781 C/T polymorphisms and osteosarcoma risk in Chinese population: a case-control study.
abstract: Interleukin-8 (IL-8) is an angiogenic chemokine that plays a potent role in both development and progression of many human malignancies. However, there are no data about the role of IL-8 polymorphism in development of osteosarcoma. A hospital-based case-control study was conducted among 190 patients with osteosarcoma and 190 healthy controls to investigate the possible association between the IL-8 -251 A/T and +781 C/T polymorphisms, respectively, and the risk of osteosarcoma. Significant differences of genotype distribution were observed between osteosarcoma cases and controls at the IL-8 -251T/A genotypes. Compared with the IL-8 -251T/A homozygote TT, the heterozygous TA genotype was associated with significantly increased risk for osteosarcoma (odds ratio (OR) = 2.16, 95 % confidence interval (CI) = (1.38-4.52), P = 0.021); the AA genotype was associated with increased risk for osteosarcoma (OR = 1.94, 95 % CI = 1.31-3.83, P = 0.018). TA and AA combined variants were associated with increased risk for osteosarcoma compared with the TT genotype (OR = 1.72, 95 % CI = 1.45-4.41, P = 0.023). Moreover, the genotype AA of IL-8 -251T/A carried a higher risk of osteosarcoma metastasis and later Enneking stages, compared with the TT genotype. However, the genotype and allele frequencies of IL-8 +781 C/T polymorphisms in osteosarcoma patients were not significantly different from controls. Our results showed that the IL-8 -251 A/T genotype was associated with increased risk for development and metastasis of osteosarcoma in Chinese Han population.
authors.affiliation: Department of Orthopaedics Institute, Tianjin Hospital, No. 406 Jiefangnan Street, Tianjin, 300211, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Orthopaedics Institute, Tianjin Hospital, No. 406 Jiefangnan Street, Tianjin, 300211, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Orthopaedics, The Third Affiliated Hospital of Hebei Medical University, No. 139 Ziqiang Road, Shijiazhuang, 050051, China.
authors.forename: Song
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Orthopaedics Institute, Tianjin Hospital, No. 406 Jiefangnan Street, Tianjin, 300211, China.
authors.forename: Shaowen
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Department of Orthopaedics Institute, Tianjin Hospital, No. 406 Jiefangnan Street, Tianjin, 300211, China. dongjingming_tj@sina.com.
authors.forename: Hongfeng
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Oncology, Peking University Cancer Hospital, No. 52, Fucheng Road, Beijing, 100142, China. guoqian_tj@sina.com.
authors.forename: Jinmin
authors.initials: J
authors.lastname: Ding
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics*; D008297:Male; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D016017:Odds Ratio; D012516:Osteosarcoma / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011159:Population Surveillance; D012306:Risk; D055815:Young Adult
chemical_list: D016209:Interleukin-8
keywords: IL-8; Osteosarcoma; Single-nucleotide polymorphism; Susceptibility