title: In vitro comparison of antimicrobial effectiveness of QMix and other final irrigants in human root canals.
abstract: Final root canal irrigation stands as an effective strategy for eliminating the dentin infection. This study aimed to investigate and compare the antibacterial efficacy of QMix and other four final irrigation regimens in reducing Enterococcus faecalis within human root canals. Single-canal human teeth contaminated with E. faecalis for 4 weeks were prepared chemomechanically with sodium hypochlorite (NaOCl). Then, the teeth were randomly assigned into six groups according to the final irrigation protocols: (1) EDTA/NaOCl, 17% EDTA followed by 5.25% NaOCl; (2) EDTA/chlorhexidine (CHX), 17% EDTA followed by 2% CHX; (3) EDTA/cetrimide (CTR), 17% EDTA followed by 2% CTR; (4) MTAD; (5) QMix; and (6) control, 0.9% saline. Bacterial samples collected before instrumentation and after final irrigation were cultured and the colony-forming units (CFUs) were counted. The CFUs in the QMix, EDTA/CHX, and EDTA/CTR groups were significantly lower than those in the EDTA/NaOCl group. No significant differences were observed between the QMix, EDTA/CHX, and EDTA/CTR groups. MTAD showed weaker ability than QMix and EDTA/CHX to eliminate E. faecalis, but it caused a greater reduction in CFU than EDTA/NaOCl. Hence, the antimicrobial activity of QMix was comparable to that of EDTA/CHX and EDTA/CTR and more effective than that of EDTA/NaOCl against intracanal E. faecalis.
authors.affiliation: Department of Endodontics, School of Stomatology, Tianjin Medical University, Tianjin, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Stomatology, The First Affiliated Hospital of Henan University of TCM, Henan, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Stomatology, Affiliated Hospital of Guiyang Medical College, Guizhou, China.
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Endodontics, School of Stomatology, Tianjin Medical University, Tianjin, China.
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Endodontics, School of Stomatology, Tianjin Medical University, Tianjin, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Endodontics, School of Stomatology, Tianjin Medical University, Tianjin, China.
authors.forename: Ligeng
authors.initials: L
authors.lastname: Wu
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001645:Biguanides / Q000494:pharmacology; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000494:pharmacology; D002710:Chlorhexidine / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004492:Edetic Acid / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects; D006801:Humans; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000494:pharmacology; D012388:Root Canal Irrigants / Q000494:pharmacology*; D014092:Tooth Root / Q000187:drug effects / Q000382:microbiology*
chemical_list: D000890:Anti-Infective Agents; D001645:Biguanides; D002593:Cetrimonium Compounds; D011108:Polymers; C557698:QMix root canal irrigant; D012388:Root Canal Irrigants; D004492:Edetic Acid; D002710:Chlorhexidine; D000077286:Cetrimonium