title: An Endogenous Tachykinergic NK2/NK3 Receptor Cascade System Controlling the Release of Serotonin from Colonic Mucosa.
abstract: 5-Hydroxytryptamine (5-HT) released from colonic mucosal enterochromaffin (EC) cells is a major signaling molecule, which participates in the pathophysiological regulation of colonic functions in gut disorder including irritable bowel syndrome (IBS), but the endogenous modulator system for the 5-HT release is not yet well elucidated. Our in vitro studies in guinea-pig colon have indicated that the cascade pathway of neuronal tachykinergic NK3 receptors and NK2 receptors on peptide YY (PYY)-containing endocrine L cells represents an endogenous modulator system for 5-HT release from EC cells and that melatonin, endogenous tachykinins and PYY play important roles in modulation of the release of 5-HT from EC cells via the endogenous NK2/NK3 receptor cascade system. This review aims at examining the potential role of the endogenous tachykinergic NK2/NK3 receptor cascade system controlling the release of 5-HT from EC cells, with special attention being paid to the pathophysiology of gut disorders including IBS.
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Kojima
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tohei
authors.forename: Masashi
authors.initials: M
authors.lastname: Ikeda
authors.affiliation: Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321-0293, Japan.. s-kojima@dokkyomed.ac.jp.
authors.forename: Naohiko
authors.initials: N
authors.lastname: Anzai
mesh_terms: D000818:Animals; D003106:Colon / Q000378:metabolism*; D004759:Enterochromaffin Cells / Q000378:metabolism; D005767:Gastrointestinal Diseases / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D018041:Receptors, Neurokinin-2 / Q000378:metabolism*; D018042:Receptors, Neurokinin-3 / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D018041:Receptors, Neurokinin-2; D018042:Receptors, Neurokinin-3; D012701:Serotonin