title: Preparation of polyhedral oligomeric silsesquioxane based imprinted monolith.
abstract: Polyhedral oligomeric silsesquioxane (POSS) was successfully applied, for the first time, to prepare imprinted monolithic column with high porosity and good permeability. The imprinted monolithic column was synthesized with a mixture of PSS-(1-Propylmethacrylate)-heptaisobutyl substituted (MA 0702), naproxon (template), 4-vinylpyridine, and ethylene glycol dimethacrylate, in ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM]BF4). The influence of synthesis parameters on the retention factor and imprinting effect, including the amount of MA 0702, the ratio of template to monomer, and the ratio of monomer to crosslinker, was investigated. The greatest imprinting factor on the imprinted monolithic column prepared with MA 0702 was 22, about 10 times higher than that prepared in absence of POSS. The comparisons between MIP monoliths synthesized with POSS and without POSS were made in terms of permeability, column efficiency, surface morphology and pore size distribution. In addition, thermodynamic and Van Deemter analysis were used to evaluate the POSS-based MIP monolith.
authors.affiliation: Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.affiliation: Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Xiu-Xiu
authors.initials: XX
authors.lastname: Chen
authors.affiliation: Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China. Electronic address: huangyp100@163.com.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Huang
authors.affiliation: Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China. Electronic address: zhaoshengliu@sohu.com.
authors.forename: Zhao-Sheng
authors.initials: ZS
authors.lastname: Liu
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods*; D007093:Imidazoles / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry; D017646:Organosilicon Compounds / Q000737:chemistry*; D016062:Porosity; D011725:Pyridines / Q000737:chemistry; D013816:Thermodynamics
chemical_list: C419324:1-butyl-3-methylimidazolium tetrafluoroborate; D007093:Imidazoles; D008689:Methacrylates; D017646:Organosilicon Compounds; D011725:Pyridines; C004919:ethylene dimethacrylate; C029351:4-vinylpyridine
keywords: Molecular recognition; Molecularly imprinted polymers; Monolith; Naproxen; Polyhedral oligomeric silsesquioxane