title: Association Between COX-2 Polymorphisms and Lung Cancer Risk.
abstract: BACKGROUND Multiple relevant risk factors for lung cancer have been reported in different populations, but results of previous studies were not consistent. Therefore, a meta-analysis is necessary to summarize these outcomes and reach a relatively comprehensive conclusion. MATERIAL AND METHODS STATA 12.0 software was used for all statistical of the relationship between COX-2 polymorphisms and lung cancer risk. Inter-study heterogeneity was examined with the Q statistic (significance level at P<0.1). The publication bias among studies in the meta-analysis was analyzed with Begg's funnel plot and Egger's test. Hardy-Weinberg equilibrium was tested in all controls of the studies. RESULTS COX-2 rs20417 polymorphism had a significant association with reduced risk of lung cancer under homozygous and recessive models, and similar results were observed in white and population-based subgroups under 2 and 3 contrasts, respectively. Additionally, rs2066826 polymorphism manifested a strong correlation with increased risk of lung cancer under 5 genetic models. CONCLUSIONS In COX-2 gene, rs20417 may have a certain relationship with reduced risk of lung cancer, while rs2066826 may increase the risk of lung cancer.
authors.affiliation: Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Yunnan Provincial Tumor Hospital, Kunming, Yunnan, China (mainland).
authors.forename: Weiwei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Orthopedic Surgery, Kunming General Hospital, Kunming, Yunnan, China (mainland).
authors.forename: Xinyun
authors.initials: X
authors.lastname: Fan
authors.affiliation: Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Yunnan Provincial Tumor Hospital, Kunming, Yunnan, China (mainland).
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Radiotherapy, The Third Affiliated Hospital of Kunming Medical University, Yunnan Provincial Tumor Hospital, Kunming, Yunnan, China (mainland).
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Institute of Clinical Medicine, Kunming Medical University, Kunming, Yunnan, China (mainland).
authors.forename: Siyuan
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Yunnan Provincial Tumor Hospital, Kunming, Yunnan, China (mainland).
authors.forename: Gaofeng
authors.initials: G
authors.lastname: Li
mesh_terms: D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012984:Software
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human