title: The Role of Topiramate in the Management of Cocaine Addiction: a Possible Therapeutic Option.
abstract: Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors). Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.
authors.forename: Antonio
authors.initials: A
authors.lastname: Siniscalchi
authors.forename: Antonello
authors.initials: A
authors.lastname: Bonci
authors.forename: Nicola
authors.initials: N
authors.lastname: Biagio Mercuri
authors.forename: Domenico
authors.initials: D
authors.lastname: Pirritano
authors.forename: Aida
authors.initials: A
authors.lastname: Squillace
authors.forename: Giovambattista
authors.initials: G
authors.lastname: De Sarro
authors.affiliation: Clinical Specialist (Neurologist), Department of Neurology, Annunziata Hospital, Via F. Migliori, 1 - 87100 Cosenza, Italy. anto.siniscalchi@libero.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Gallelli
mesh_terms: D000818:Animals; D002491:Central Nervous System Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000378:metabolism; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D000077236:Topiramate
chemical_list: D002491:Central Nervous System Agents; D000077236:Topiramate; D005632:Fructose