title: Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?
abstract: The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in animal models in a wide range of tumour types. How do we move forward into the clinical setting and translate something which has such potential into meaningful clinical outcomes? Here, we review how the field of oncolytic virotherapy has developed thus far and what the future may hold.
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS2 9JT, UK. s.j.turnbull@leeds.ac.uk.
authors.forename: Samantha
authors.initials: S
authors.lastname: Turnbull
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS2 9JT, UK. e.j.west@leeds.ac.uk.
authors.forename: Emma J
authors.initials: EJ
authors.lastname: West
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS2 9JT, UK. k.j.scott@leeds.ac.uk.
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Scott
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS2 9JT, UK. elizabethappleton@doctors.org.uk.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Appleton
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS2 9JT, UK. a.a.melcher@leeds.ac.uk.
authors.forename: Alan
authors.initials: A
authors.lastname: Melcher
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS2 9JT, UK. c.ralph@leeds.ac.uk.
authors.forename: Christy
authors.initials: C
authors.lastname: Ralph
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D050130:Oncolytic Virotherapy / Q000379:methods* / Q000639:trends
keywords: HSV; clinical trials; immunotherapy; oncolytic virus; reovirus; vaccinia