title: Medication and aggressiveness in real-world schizophrenia. Results from the FACE-SZ dataset.
abstract: BACKGROUND
  The primary objective of this study was to determine if second-generation antipsychotic (SGA) administration was associated with lower aggressiveness scores compared to first-generation (FGA) in schizophrenia (SZ). The secondary objective was to determine if antidepressants, mood stabilizers, and benzodiazepines administration were respectively associated with lower aggressiveness scores compared to patients who were not administered these medications.
  
  
  METHODS
  Three hundred thirty-one patients with schizophrenia (N = 255) or schizoaffective disorder (N = 76) (mean age = 32.5 years, 75.5 % male gender) were systematically included in the network of FondaMental Expert Center for Schizophrenia and assessed with the structured clinical interview for DSM-IV Axis I disorders and validated scales for psychotic symptomatology, insight, and compliance. Aggressiveness was measured by the Buss-Perry Aggression Questionnaire (BPAQ) score. Ongoing psychotropic treatment was recorded.
  
  
  RESULTS
  Patients who received SGA had lower BPAQ scores than patients who did not (p = 0.01). More specifically, these patients had lower physical and verbal aggression scores. On the contrary, patients who received benzodiazepines had higher BPAQ scores than patients who did not (p = 0.04). No significant difference was found between BPAQ scores of patients respectively being administered mood stabilizers (including valproate), antidepressant, and the patients who were not. These results were found independently of socio-demographical variables, psychotic symptomatology, insight, compliance into treatment, daily-administered antipsychotic dose, the way of antipsychotic administration (oral vs long acting), current alcohol disorder, and daily cannabis consumption.
  
  
  CONCLUSIONS
  The results of the present study are in favor of the choice of SGA in SZ patients with aggressiveness, but these results need further investigation in longitudinal studies. Given the potent side effects of benzodiazepines (especially dependency and cognitive impairment) and the results of the present study, their long-term prescription is not recommended in patients with schizophrenia and aggressive behavior.
authors.affiliation: Fondation FondaMental, Créteil, France. guillaume.fond@gmail.com.|INSERM U955, équipe de psychiatrie translationnelle, Créteil, France, Université Paris-Est Créteil, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, 40 rue de Mesly, F-94010, Créteil, France. guillaume.fond@gmail.com.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France. guillaume.fond@gmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Fond
authors.affiliation: Fondation FondaMental, Créteil, France.|Pôle Psychiatrie Universitaire, CHU Sainte-Marguerite, F-13274, Marseille cedex 09, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: L
authors.initials: L
authors.lastname: Boyer
authors.affiliation: INSERM U955, équipe de psychiatrie translationnelle, Créteil, France, Université Paris-Est Créteil, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, 40 rue de Mesly, F-94010, Créteil, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: M
authors.initials: M
authors.lastname: Favez
authors.affiliation: Fondation FondaMental, Créteil, France.|INSERM U955, équipe de psychiatrie translationnelle, Créteil, France, Université Paris-Est Créteil, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, 40 rue de Mesly, F-94010, Créteil, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: L
authors.initials: L
authors.lastname: Brunel
authors.affiliation: Fondation FondaMental, Créteil, France.|Centre Hospitalier Charles Perrens, Université de Bordeaux, F-33076, Bordeaux, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.|Inserm, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862, F-33000, Bordeaux, France.
authors.forename: B
authors.initials: B
authors.lastname: Aouizerate
authors.affiliation: Fondation FondaMental, Créteil, France.|INSERM U1114, Fédération de Médecine Translationnelle de Strasbourg, Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Berna
authors.affiliation: Fondation FondaMental, Créteil, France.|Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHRU Montpellier, Université Montpellier 1, Inserm 1061, Montpellier, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: D
authors.initials: D
authors.lastname: Capdevielle
authors.affiliation: Fondation FondaMental, Créteil, France.|CMP B, CHU, EA 7280 Faculté de Médecine, Université d'Auvergne, BP 69 63003, Clermont-Ferrand Cedex 1, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: I
authors.initials: I
authors.lastname: Chereau
authors.affiliation: Fondation FondaMental, Créteil, France.|Université Claude Bernard Lyon 1/Centre Hospitalier Le Vinatier, Pole Est BP 300 39-95 bd, Pinel - 69678, BRON Cedex, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Dorey
authors.affiliation: Fondation FondaMental, Créteil, France.|AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, Inserm U894, Université Paris Diderot, Faculté de médecine, Sorbonne, Paris Cité, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: C
authors.initials: C
authors.lastname: Dubertret
authors.affiliation: Fondation FondaMental, Créteil, France.|Centre Référent de Réhabilitation Psychosociale, CH Alpes Isère, Grenoble, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.lastname: Dubreucq
authors.affiliation: Fondation FondaMental, Créteil, France.|Assistance Publique des Hôpitaux de Marseille (AP-HM), Pôle Universitaire de Psychiatrie, Marseille, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: C
authors.initials: C
authors.lastname: Faget
authors.affiliation: Fondation FondaMental, Créteil, France.|Centre Référent de Réhabilitation Psychosociale, CH Alpes Isère, Grenoble, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Gabayet
authors.affiliation: Fondation FondaMental, Créteil, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: H
authors.initials: H
authors.lastname: Laouamri
authors.affiliation: Fondation FondaMental, Créteil, France.|Assistance Publique des Hôpitaux de Marseille (AP-HM), Pôle Universitaire de Psychiatrie, Marseille, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: C
authors.initials: C
authors.lastname: Lancon
authors.affiliation: Fondation FondaMental, Créteil, France.|AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, Inserm U894, Université Paris Diderot, Faculté de médecine, Sorbonne, Paris Cité, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Le Strat
authors.affiliation: Fondation FondaMental, Créteil, France.|Centre Hospitalier Charles Perrens, Université de Bordeaux, F-33076, Bordeaux, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.|CNRS UMR 5287-INCIA, Bordeaux, France.
authors.forename: D
authors.initials: D
authors.lastname: Misdrahi
authors.affiliation: Fondation FondaMental, Créteil, France.|Université Claude Bernard Lyon 1/Centre Hospitalier Le Vinatier, Pole Est BP 300 39-95 bd, Pinel - 69678, BRON Cedex, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: R
authors.initials: R
authors.lastname: Rey
authors.affiliation: Fondation FondaMental, Créteil, France.|Service de psychiatrie d'adulte, Centre Hospitalier de Versailles, UFR des Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin en Yvelines, Versailles, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: C
authors.initials: C
authors.lastname: Passerieux
authors.affiliation: Fondation FondaMental, Créteil, France.|Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHRU Montpellier, Université Montpellier 1, Inserm 1061, Montpellier, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: A
authors.initials: A
authors.lastname: Schandrin
authors.affiliation: Fondation FondaMental, Créteil, France.|INSERM U955, équipe de psychiatrie translationnelle, Créteil, France, Université Paris-Est Créteil, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, 40 rue de Mesly, F-94010, Créteil, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Schurhoff
authors.affiliation: Fondation FondaMental, Créteil, France.|CMP B, CHU, EA 7280 Faculté de Médecine, Université d'Auvergne, BP 69 63003, Clermont-Ferrand Cedex 1, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Tronche
authors.affiliation: Fondation FondaMental, Créteil, France.|Service de psychiatrie d'adulte, Centre Hospitalier de Versailles, UFR des Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin en Yvelines, Versailles, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: M
authors.initials: M
authors.lastname: Urbach
authors.affiliation: INSERM U1114, Fédération de Médecine Translationnelle de Strasbourg, Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: P
authors.initials: P
authors.lastname: Vidalhet
authors.affiliation: Fondation FondaMental, Créteil, France.|CMP B, CHU, EA 7280 Faculté de Médecine, Université d'Auvergne, BP 69 63003, Clermont-Ferrand Cedex 1, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: P M
authors.initials: PM
authors.lastname: Llorca
authors.affiliation: Fondation FondaMental, Créteil, France.|INSERM U955, équipe de psychiatrie translationnelle, Créteil, France, Université Paris-Est Créteil, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, 40 rue de Mesly, F-94010, Créteil, France.|Bordeaux Sleep Clinique, Pellegrin University Hospital, USR CNRS 3413 SANPSY, Research Unit, Bordeaux University, 33000, Bordeaux, France.
authors.forename: A
authors.initials: A
authors.lastname: Pelissolo
mesh_terms: D000328:Adult; D000374:Aggression / Q000187:drug effects* / Q000523:psychology; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000009:adverse effects / Q000627:therapeutic use*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D016208:Databases, Factual / Q000639:trends; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology; D012559:Schizophrenia / Q000188:drug therapy* / Q000453:epidemiology; D012565:Schizophrenic Psychology; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines
keywords: Aggressiveness; Antipsychotic; Benzodiazepine; Buss perry scale; Schizophrenia; Violence