title: Reversible Fluorescent Probes for Biological Redox States.
abstract: The redox chemistry of the cell is key to its function and health, and the development of chemical tools to study redox biology is important. While fluxes in oxidative state are essential for healthy cell function, a chronically elevated oxidative capacity is linked to disease. It is therefore essential that probes of biological redox states distinguish between these two conditions by the reversible sensing of changes over time. In this review, we discuss the current progress towards such probes, and identify key directions for future research in this nascent field of vital biological interest.
authors.affiliation: School of Chemistry, The University of Sydney, NSW, 2006, Australia.
authors.forename: Amandeep
authors.initials: A
authors.lastname: Kaur
authors.affiliation: School of Chemistry, The University of Sydney, NSW, 2006, Australia.
authors.forename: Jacek L
authors.initials: JL
authors.lastname: Kolanowski
authors.affiliation: School of Chemistry, The University of Sydney, NSW, 2006, Australia. elizabeth.new@sydney.edu.au.
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: New
mesh_terms: D000818:Animals; D002460:Cell Line; D018011:Chalcogens / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D009536:Niacinamide / Q000737:chemistry; D009589:Nitrogen Oxides / Q000737:chemistry; D010084:Oxidation-Reduction; D011809:Quinones / Q000737:chemistry
chemical_list: D018011:Chalcogens; D005456:Fluorescent Dyes; D009589:Nitrogen Oxides; D011809:Quinones; D009536:Niacinamide
keywords: biosensors; fluorescent probes; imaging agents; oxidative stress; redox chemistry