title: Leukemogenic Activity of Cohesin Rings True.
abstract: Cohesin complex components are frequently mutated in human myeloid cancers. Three new studies now show that cohesin mutations disrupt the differentiation of normal hematopoietic stem and progenitor cells and enhance self-renewal, shedding light on how these alterations may contribute to leukemic transformation.
authors.affiliation: Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Williams
authors.affiliation: Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK. Electronic address: tim.somervaille@cruk.manchester.ac.uk.
authors.forename: Tim C P
authors.initials: TCP
authors.lastname: Somervaille
mesh_terms: D002454:Cell Differentiation; D019337:Hematologic Neoplasms; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D009154:Mutation; D009196:Myeloproliferative Disorders