title: [Severe neutropenia as side effect of medical treatment in nontuberculous mycobacterial adenitis].
abstract: Non-tuberculous mycobacterial adenitis is getting more common in our environment. Epidemiologic studies and clinical trials published nowadays are limited. We present a 2-years-old boy diagnosed of Mycobacterium intracellulare adenitis and severe neutropenia as side effect of combined treatment with oral azythromycin and rifabutin, which recovers after suspending the second one. Liver metabolism of macrolide seems to increase other drugs toxicity, in this case, rifabutin. The patient eventually needed surgery due to persistence of the adenitis despite treatment with antibiotics.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Ruíz del Olmo
authors.forename: Beatriz
authors.initials: B
authors.lastname: Romera
authors.forename: Carmelo
authors.initials: C
authors.lastname: Guerrero
authors.forename: Pedro
authors.initials: P
authors.lastname: Burgués
authors.forename: Matilde
authors.initials: M
authors.lastname: Bustillo
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D017963:Azithromycin / Q000009:adverse effects*; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D006801:Humans; D008199:Lymphadenitis / Q000382:microbiology / Q000628:therapy; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy; D009503:Neutropenia / Q000139:chemically induced*; D017828:Rifabutin / Q000009:adverse effects*; D012720:Severity of Illness Index
chemical_list: D000900:Anti-Bacterial Agents; D017828:Rifabutin; D017963:Azithromycin