title: High-density lipoprotein mimetics: promises and challenges.
abstract: The concept of lipoprotein mimetics was developed and extensively tested in the last three decades. Most lipoprotein mimetics were designed to recreate one or several functions of high-density lipoprotein (HDL) in the context of cardiovascular disease; however, the application of this approach is much broader. Lipoprotein mimetics should not just be seen as a set of compounds aimed at replenishing a deficiency or dysfunctionality of individual elements of lipoprotein metabolism but rather as a designer concept with remarkable flexibility and numerous applications in medicine and biology. In the present review, we discuss the fundamental design principles used to create lipoprotein mimetics, mechanisms of their action, medical indications and efficacy in animal models and human studies.
authors.affiliation: Laboratory of Lipoproteins and Atherosclerosis, Baker IDI Heart and Diabetes Institute, Melbourne, VIC 3004, Australia Dmitri.Sviridov@bakeridi.edu.au.
authors.forename: Dmitri
authors.initials: D
authors.lastname: Sviridov
authors.affiliation: Lipoprotein Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, U.S.A.
authors.forename: Alan T
authors.initials: AT
authors.lastname: Remaley
mesh_terms: D000818:Animals; D015195:Drug Design; D006801:Humans; D008075:Lipoproteins, HDL; D057786:Peptidomimetics
chemical_list: D008075:Lipoproteins, HDL; D057786:Peptidomimetics
keywords: apolipoproteins; atherosclerosis; cholesterol metabolism; lipoprotein metabolism; peptides