title: Inflammatory Mechanisms in Hidradenitis Suppurativa.
abstract: Hidradenitis suppurativa (HS) is a chronic relapsing disease of follicular occlusion that causes immense clinical and psychosocial morbidity when refractory to treatment. HS is no longer considered a disease of primary infectious etiology, although bacteria play a role. There is increasing evidence that HS is associated with immune dysregulation, based on its clinical association with other immune-mediated disorders, by its response to biologic therapy in the clinical arena, and from molecular research. This article summarizes what is known in relation to the inflammatory pathways in HS.
authors.affiliation: Department of Dermatology, St. Vincent's University Hospital, Dublin 4, Ireland. Electronic address: gkellywinter@gmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Kelly
authors.affiliation: Department of Dermatology, Erasmus University Medical Centre Rotterdam, s-Gravendijkwal 230, 3015 CE Rotterdam, Netherlands.
authors.forename: Errol P
authors.initials: EP
authors.lastname: Prens
mesh_terms: D001424:Bacterial Infections / Q000276:immunology; D002921:Cicatrix / Q000276:immunology; D016207:Cytokines / Q000276:immunology*; D017497:Hidradenitis Suppurativa / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D012907:Smoking / Q000453:epidemiology / Q000276:immunology*; D015163:Superinfection / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D016207:Cytokines; D051193:Toll-Like Receptors
keywords: Cytokines; Hidradenitis suppurativa; Immunology; Inflammation; Pathogenesis