title: Pd(II)-catalyzed intramolecular oxidative Heck dearomative reaction: approach to thiazole-fused pyrrolidinones with a C2-azaquarternary center.
abstract: A Pd(II)-catalyzed intramolecular oxidative Heck dearomative reaction for the construction of thiazole-fused pyrrolidinones with a C2-azaquarternary center and C3-exo-double bond has been achieved for the first time. The reaction exhibited good functional group tolerance and gram-scale capacity.
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China. ajlin@cpu.edu.cn hyao@cpu.edu.cn.
authors.forename: Shang
authors.initials: S
authors.lastname: Gao
authors.forename: Chi
authors.initials: C
authors.lastname: Yang
authors.forename: Yue
authors.initials: Y
authors.lastname: Huang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Wu
authors.forename: Hequan
authors.initials: H
authors.lastname: Yao
authors.forename: Aijun
authors.initials: A
authors.lastname: Lin