title: Understanding the Roles of the NF-κB Pathway in Regulatory T Cell Development, Differentiation and Function.
abstract: The nuclear factor of kappaB (NF-κB) pathway has emerged as an important regulator of gene expression in CD4(+) regulatory T cells. Here, we review various aspects of the roles NF-κB signaling plays in the development and function of Tregs.
authors.affiliation: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Fulford
authors.affiliation: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
authors.forename: Darcy
authors.initials: D
authors.lastname: Ellis
authors.affiliation: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia. Electronic address: steven.gerondakis@monash.edu.
authors.forename: Steve
authors.initials: S
authors.lastname: Gerondakis
mesh_terms: D002454:Cell Differentiation; D006801:Humans; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism*; D015398:Signal Transduction; D050378:T-Lymphocytes, Regulatory / Q000166:cytology* / Q000378:metabolism*
chemical_list: D016328:NF-kappa B
keywords: Immune homeostasis; Nuclear factor kappaB; Treg development; Treg function; c-Rel