title: Association of epicardial adipose tissue thickness and inflammation parameters with CHA2DS2-VASASc score in patients with nonvalvular atrial fibrillation.
abstract: BACKGROUND
  Epicardial adipose tissue (EAT), mean platelet volume (MPV), platelet-to- lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) have been shown to be helpful in predicting adverse cardiovascular events. However, to date, in the literature, there have been no studies demonstrating the relationship between EAT, MPV, PLR, NLR, and thromboembolism risk in atrial fibrillation (AF). Therefore, we examined the relationship between EAT, MPV, PLR, NLR, and CHA2DS2-VASc score used for the evaluation of thromboembolism risk in patients with AF.
  
  
  METHODS
  The study included 96 consecutive patients with AF and 52 age- and sex-matched control subjects. We calculated CHA2DS2-VASc risk score for each patient and measured baseline EAT thickness, MPV, PLR, NLR, left atrial volume index, and left ventricular ejection fraction.
  
  
  RESULTS
  The group with high CHA2DS2-VASc score had higher EAT (7.2±1.5 vs 5.9±1.2 mm, P<0.001), MPV (9.1±1.1 vs 8.4±1.0 fL, P=0.004), PLR (152.3±28.4 vs 126.7±25.4, P=0.001), and NLR (4.0±1.6 vs 3.2±1.3, P<0.001) compared to group with low-intermediate CHA2DS2-VASc score. Moreover, CHA2DS2-VASc score was found to be positively correlated with EAT (r=0.623, P<0.001), MPV (r=0.350, P=0.004), PLR (r=0.398, P=0.001), and NLR (r=0.518, P<0.001).
  
  
  CONCLUSIONS
  Our study results demonstrated that EAT thickness, MPV, PLR, and NLR were associated with the thromboembolic risk exhibited by CHA2DS2-VASc score in patients with nonvalvular AF.
authors.affiliation: Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Akdag
authors.affiliation: Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Hakki
authors.initials: H
authors.lastname: Simsek
authors.affiliation: Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Musa
authors.initials: M
authors.lastname: Sahin
authors.affiliation: Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Aytac
authors.initials: A
authors.lastname: Akyol
authors.affiliation: Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Duz
authors.affiliation: Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Naci
authors.initials: N
authors.lastname: Babat
keywords: atrial fibrillation; epicardial adipose tissue; mean platelet volume; neutrophil; platelet