title: Clinical implications of the global multidrug-resistant tuberculosis epidemic.
abstract: Multidrug-resistant tuberculosis (MDR TB) is a significant threat to global health estimated to account for nearly half a million new cases and over 200,000 deaths in 2013. The number of MDR TB cases in the UK has risen over the last 15 years, with ever more complex clinical cases and associated challenging public health and societal implications. In this review, we provide an overview of the epidemiology of MDR TB globally and in the UK, outline the clinical management of MDR TB and summarise recent advances in diagnostics and prospects for new treatment.
authors.affiliation: Centre for Infectious Disease Epidemiology, Research Department of Infection and Population Health, University College London, London, UK, and The Whittington Hospital NHS Trust, Whittington Health, London, UK;
authors.forename: Kartik
authors.initials: K
authors.lastname: Kumar
authors.affiliation: Centre for Infectious Disease Epidemiology, University College London, London, UK, and MRC Clinical Trials Unit, University College London, London, UK i.abubakar@ucl.ac.uk.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Abubakar
mesh_terms: D058872:Epidemics / Q000517:prevention & control / Q000706:statistics & numerical data; D014943:Global Health; D006801:Humans; D058889:Molecular Typing; D009169:Mycobacterium tuberculosis; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D006113:United Kingdom / Q000453:epidemiology
keywords: Multidrug-resistant tuberculosis; epidemiology; treatment; ­diagnostics