title: Dysfunctional feedback processing in adolescent males with conduct disorder.
abstract: Abnormalities in neural feedback-processing systems may play a role in the development of dysfunctional behavior in individuals diagnosed with conduct disorder (CD). The present study investigated the relation between CD adolescents and feedback processing by measuring event-related potentials (ERPs) in a single outcome gambling task, which included reward valence (loss and gain) and reward magnitude (10 and 50cents) as outcomes. N2 and P3 components have been established as effective indicators in studies of behavioral disinhibition, reward processing, and decision-making. Eighteen adolescent males (age: 13-17years) diagnosed with CD and 19 healthy age-matched male controls were recruited. Compared to healthy controls, CD individuals exhibited reduced N2 amplitudes in response to loss condition. There was also a significant decreased P3 amplitude in all conditions. The amplitudes of P3 were negatively correlated with impulsivity scores across both groups, and the amplitudes of N2 were positively correlated with impulsivity scores across both groups. Our findings suggest that adolescents with CD may be impaired in neural sensitivity feedback and the processing of environmental cues compared to healthy controls. Moreover, N2 and P3 may be reliable indices to detect different sensitivity in reward and punishment feedback processing.
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address: edengao007@163.com.
authors.forename: Yidian
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address: chenhy1987@163.com.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address: jia.hui.qiao@hotmail.com.
authors.forename: Huiqiao
authors.initials: H
authors.lastname: Jia
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address: mingqingsen@163.com.
authors.forename: Qingsen
authors.initials: Q
authors.lastname: Ming
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address: jinyaoyi@gmail.com.
authors.forename: Jinyao
authors.initials: J
authors.lastname: Yi
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; National Province Technology Institute of Psychiatry, Central South University, Changsha, Hunan 410011, China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China. Electronic address: shuqiaoyao@163.com.
authors.forename: Shuqiao
authors.initials: S
authors.lastname: Yao
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000502:physiology* / Q000523:psychology*; D001676:Biofeedback, Psychology / Q000502:physiology*; D019955:Conduct Disorder / Q000175:diagnosis* / Q000523:psychology*; D003430:Cross-Sectional Studies; D004569:Electroencephalography / Q000379:methods; D018913:Event-Related Potentials, P300 / Q000502:physiology; D005715:Gambling / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D008297:Male
keywords: Conduct disorder; ERPs; Feedback processing