title: The Key Proteins of Dopaminergic Neurotransmission of Human Peripheral Blood Lymphocytes: Changed mRNA Level in Alcohol Dependence Syndrome.
abstract: The expression of dopamine receptor (DRD), Nurr1 transcription factor (NR4A2), and α-sinucleine (SNCA) genes in peripheral blood lymphocytes is evaluated. The results indicate that alcohol dependence is associated with high expression of SNCA and DRD4 (signifi cantly higher than in the control group) and is not associated with changes in the work of NR4A2 and DRD3 genes. The levels of DRD3 and DRD4 mRNA form a positive linear correlation (p≤0.05). The expression of SNCA and DRD4 genes can serve as an important peripheral marker of alcohol dependence development, which is essential for antipsychotic therapy.
authors.affiliation: B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia. ataraskina@mail.ru.|I. P. Pavlov St. Petersburg First State Medical University, the Ministry of Health of Russia, St. Petersburg, Russia. ataraskina@mail.ru.|V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia. ataraskina@mail.ru.
authors.forename: A E
authors.initials: AE
authors.lastname: Taraskina
authors.affiliation: B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia.
authors.forename: M N
authors.initials: MN
authors.lastname: Grunina
authors.affiliation: B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Zabotina
authors.affiliation: V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia.
authors.forename: R F
authors.initials: RF
authors.lastname: Nasyrova
authors.affiliation: V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Ivanov
authors.affiliation: V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia.
authors.forename: E M
authors.initials: EM
authors.lastname: Krupitsky
authors.affiliation: B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Schwartzman
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D011954:Receptors, Dopamine / Q000235:genetics / Q000378:metabolism; D050637:Receptors, Dopamine D3 / Q000235:genetics / Q000378:metabolism; D009435:Synaptic Transmission / Q000235:genetics / Q000502:physiology
chemical_list: D012333:RNA, Messenger; D011954:Receptors, Dopamine; D050637:Receptors, Dopamine D3
keywords: alcohol dependence syndrome; dopaminergic neurotransmission proteins; gene expression; peripheral blood lymphocytes; real time quantitative polymerase chain reaction