title: Summary Findings of a Systematic Literature Review of the Ultrasound Assessment of Bone Erosions in Rheumatoid Arthritis.
abstract: OBJECTIVE
  Bone erosions in rheumatoid arthritis (RA) have been studied in an increasing amount of research. Both earlier and present classification criteria of RA contain erosions as a significant classification component. Ultrasound (US) can detect bone changes in accessible surfaces. Therefore, the study group performed a systematic literature review of assessment of RA bone erosions with US.
  
  
  METHODS
  A systematic search of PubMed and Embase was performed. Data on the definitions of RA bone erosions, their size, scoring, relation to synovitis, comparators, and elements of the OMERACT (Outcome Measures in Rheumatology Clinical Trials) filter were collected and analyzed.
  
  
  RESULTS
  The selection process identified 58 original research papers. The assessed joints were most frequently metacarpophalangeal (MCP; 41 papers), proximal interphalangeal (19 papers), and metatarsophalangeal joints (MTP; 18 papers). The OMERACT definition of RA bone erosion on US was used most often (17 papers). Second and fifth MCP and fifth MTP were recommended as target joints. Conventional radiography was the most frequently used comparator (27 papers), then magnetic resonance imaging (17 papers) and computed tomography (5 papers). Reliability of assessment was presented in 20 papers and sensitivity to change in 11 papers.
  
  
  CONCLUSIONS
  This paper presents results of a systematic literature review of bone erosion assessment in RA with US. The survey suggests that US can be a helpful adjunct to the existing methods of imaging bone erosions in RA. It analyzes definitions, scoring systems, used comparators, and elements of the OMERACT filter. It also presents recommendations for a future research agenda based on the results of the review.
authors.affiliation: From the Department of Rheumatology, Copenhagen University Hospital at Køge, Køge; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM) Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin, Berlin; Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology, Berlin-Buch, Germany; Third Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Ancona; Rheumatology Unit, Dipartmento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy; Rheumatology Department, Université Paris 6-Pierre et Marie Curie, Hôpital La Pitié Salpetrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris; Rheumatology Department, Université Paris Ouest-Versailles-Saint Quentin en Yvelines, Hôpital Ambroise Paré, Boulogne-Billancourt, France; Division of Rheumatology, University of Vienna, Vienna, Austria; Instituto Poal de Reumatologia-Hospital Platon, Barcelona; Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain.M. Szkudlarek, MD, PhD, Department of Rheumatology, Copenhagen University Hospital at Køge; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup; R.J. Wakefield, BM, FRCP, MD, Senior Lecturer and Honorary Consultant Rheumatologist, LIRMM Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital; M. Backhaus, Professor, Dr. Med., Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin; P.V. Balint, MD, PhD, FRCP, Third Department of Rheumatology, Nationa
authors.forename: Marcin
authors.initials: M
authors.lastname: Szkudlarek
authors.affiliation: From the Department of Rheumatology, Copenhagen University Hospital at Køge, Køge; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM) Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin, Berlin; Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology, Berlin-Buch, Germany; Third Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Ancona; Rheumatology Unit, Dipartmento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy; Rheumatology Department, Université Paris 6-Pierre et Marie Curie, Hôpital La Pitié Salpetrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris; Rheumatology Department, Université Paris Ouest-Versailles-Saint Quentin en Yvelines, Hôpital Ambroise Paré, Boulogne-Billancourt, France; Division of Rheumatology, University of Vienna, Vienna, Austria; Instituto Poal de Reumatologia-Hospital Platon, Barcelona; Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain.M. Szkudlarek, MD, PhD, Department of Rheumatology, Copenhagen University Hospital at Køge; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup; R.J. Wakefield, BM, FRCP, MD, Senior Lecturer and Honorary Consultant Rheumatologist, LIRMM Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital; M. Backhaus, Professor, Dr. Med., Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin; P.V. Balint, MD, PhD, FRCP, Third Department of Rheumatology, Nationa
authors.forename: Lene
authors.initials: L
authors.lastname: Terslev
authors.affiliation: From the Department of Rheumatology, Copenhagen University Hospital at Køge, Køge; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM) Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin, Berlin; Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology, Berlin-Buch, Germany; Third Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Ancona; Rheumatology Unit, Dipartmento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy; Rheumatology Department, Université Paris 6-Pierre et Marie Curie, Hôpital La Pitié Salpetrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris; Rheumatology Department, Université Paris Ouest-Versailles-Saint Quentin en Yvelines, Hôpital Ambroise Paré, Boulogne-Billancourt, France; Division of Rheumatology, University of Vienna, Vienna, Austria; Instituto Poal de Reumatologia-Hospital Platon, Barcelona; Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain.M. Szkudlarek, MD, PhD, Department of Rheumatology, Copenhagen University Hospital at Køge; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup; R.J. Wakefield, BM, FRCP, MD, Senior Lecturer and Honorary Consultant Rheumatologist, LIRMM Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital; M. Backhaus, Professor, Dr. Med., Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin; P.V. Balint, MD, PhD, FRCP, Third Department of Rheumatology, Nationa
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Wakefield
authors.affiliation: From the Department of Rheumatology, Copenhagen University Hospital at Køge, Køge; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM) Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin, Berlin; Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology, Berlin-Buch, Germany; Third Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Ancona; Rheumatology Unit, Dipartmento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy; Rheumatology Department, Université Paris 6-Pierre et Marie Curie, Hôpital La Pitié Salpetrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris; Rheumatology Department, Université Paris Ouest-Versailles-Saint Quentin en Yvelines, Hôpital Ambroise Paré, Boulogne-Billancourt, France; Division of Rheumatology, University of Vienna, Vienna, Austria; Instituto Poal de Reumatologia-Hospital Platon, Barcelona; Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain.M. Szkudlarek, MD, PhD, Department of Rheumatology, Copenhagen University Hospital at Køge; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup; R.J. Wakefield, BM, FRCP, MD, Senior Lecturer and Honorary Consultant Rheumatologist, LIRMM Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital; M. Backhaus, Professor, Dr. Med., Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin; P.V. Balint, MD, PhD, FRCP, Third Department of Rheumatology, Nationa
authors.forename: Marina
authors.initials: M
authors.lastname: Backhaus
authors.affiliation: From the Department of Rheumatology, Copenhagen University Hospital at Køge, Køge; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM) Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin, Berlin; Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology, Berlin-Buch, Germany; Third Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Ancona; Rheumatology Unit, Dipartmento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy; Rheumatology Department, Université Paris 6-Pierre et Marie Curie, Hôpital La Pitié Salpetrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris; Rheumatology Department, Université Paris Ouest-Versailles-Saint Quentin en Yvelines, Hôpital Ambroise Paré, Boulogne-Billancourt, France; Division of Rheumatology, University of Vienna, Vienna, Austria; Instituto Poal de Reumatologia-Hospital Platon, Barcelona; Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain.M. Szkudlarek, MD, PhD, Department of Rheumatology, Copenhagen University Hospital at Køge; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup; R.J. Wakefield, BM, FRCP, MD, Senior Lecturer and Honorary Consultant Rheumatologist, LIRMM Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital; M. Backhaus, Professor, Dr. Med., Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin; P.V. Balint, MD, PhD, FRCP, Third Department of Rheumatology, Nationa
authors.forename: Peter V
authors.initials: PV
authors.lastname: Balint
authors.affiliation: From the Department of Rheumatology, Copenhagen University Hospital at Køge, Køge; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM) Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin, Berlin; Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology, Berlin-Buch, Germany; Third Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Ancona; Rheumatology Unit, Dipartmento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy; Rheumatology Department, Université Paris 6-Pierre et Marie Curie, Hôpital La Pitié Salpetrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris; Rheumatology Department, Université Paris Ouest-Versailles-Saint Quentin en Yvelines, Hôpital Ambroise Paré, Boulogne-Billancourt, France; Division of Rheumatology, University of Vienna, Vienna, Austria; Instituto Poal de Reumatologia-Hospital Platon, Barcelona; Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain.M. Szkudlarek, MD, PhD, Department of Rheumatology, Copenhagen University Hospital at Køge; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup; R.J. Wakefield, BM, FRCP, MD, Senior Lecturer and Honorary Consultant Rheumatologist, LIRMM Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital; M. Backhaus, Professor, Dr. Med., Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin; P.V. Balint, MD, PhD, FRCP, Third Department of Rheumatology, Nationa
authors.forename: George A W
authors.initials: GA
authors.lastname: Bruyn
authors.affiliation: From the Department of Rheumatology, Copenhagen University Hospital at Køge, Køge; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM) Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin, Berlin; Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology, Berlin-Buch, Germany; Third Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Ancona; Rheumatology Unit, Dipartmento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy; Rheumatology Department, Université Paris 6-Pierre et Marie Curie, Hôpital La Pitié Salpetrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris; Rheumatology Department, Université Paris Ouest-Versailles-Saint Quentin en Yvelines, Hôpital Ambroise Paré, Boulogne-Billancourt, France; Division of Rheumatology, University of Vienna, Vienna, Austria; Instituto Poal de Reumatologia-Hospital Platon, Barcelona; Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain.M. Szkudlarek, MD, PhD, Department of Rheumatology, Copenhagen University Hospital at Køge; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup; R.J. Wakefield, BM, FRCP, MD, Senior Lecturer and Honorary Consultant Rheumatologist, LIRMM Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital; M. Backhaus, Professor, Dr. Med., Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin; P.V. Balint, MD, PhD, FRCP, Third Department of Rheumatology, Nationa
authors.forename: Emilio
authors.initials: E
authors.lastname: Filippucci
authors.affiliation: From the Department of Rheumatology, Copenhagen University Hospital at Køge, Køge; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM) Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin, Berlin; Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology, Berlin-Buch, Germany; Third Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Ancona; Rheumatology Unit, Dipartmento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy; Rheumatology Department, Université Paris 6-Pierre et Marie Curie, Hôpital La Pitié Salpetrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris; Rheumatology Department, Université Paris Ouest-Versailles-Saint Quentin en Yvelines, Hôpital Ambroise Paré, Boulogne-Billancourt, France; Division of Rheumatology, University of Vienna, Vienna, Austria; Instituto Poal de Reumatologia-Hospital Platon, Barcelona; Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain.M. Szkudlarek, MD, PhD, Department of Rheumatology, Copenhagen University Hospital at Køge; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup; R.J. Wakefield, BM, FRCP, MD, Senior Lecturer and Honorary Consultant Rheumatologist, LIRMM Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital; M. Backhaus, Professor, Dr. Med., Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin; P.V. Balint, MD, PhD, FRCP, Third Department of Rheumatology, Nationa
authors.forename: Frederique
authors.initials: F
authors.lastname: Gandjbakhch
authors.affiliation: From the Department of Rheumatology, Copenhagen University Hospital at Køge, Køge; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM) Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin, Berlin; Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology, Berlin-Buch, Germany; Third Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Ancona; Rheumatology Unit, Dipartmento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy; Rheumatology Department, Université Paris 6-Pierre et Marie Curie, Hôpital La Pitié Salpetrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris; Rheumatology Department, Université Paris Ouest-Versailles-Saint Quentin en Yvelines, Hôpital Ambroise Paré, Boulogne-Billancourt, France; Division of Rheumatology, University of Vienna, Vienna, Austria; Instituto Poal de Reumatologia-Hospital Platon, Barcelona; Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain.M. Szkudlarek, MD, PhD, Department of Rheumatology, Copenhagen University Hospital at Køge; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup; R.J. Wakefield, BM, FRCP, MD, Senior Lecturer and Honorary Consultant Rheumatologist, LIRMM Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital; M. Backhaus, Professor, Dr. Med., Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin; P.V. Balint, MD, PhD, FRCP, Third Department of Rheumatology, Nationa
authors.forename: Annamaria
authors.initials: A
authors.lastname: Iagnocco
authors.affiliation: From the Department of Rheumatology, Copenhagen University Hospital at Køge, Køge; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM) Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin, Berlin; Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology, Berlin-Buch, Germany; Third Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Ancona; Rheumatology Unit, Dipartmento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy; Rheumatology Department, Université Paris 6-Pierre et Marie Curie, Hôpital La Pitié Salpetrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris; Rheumatology Department, Université Paris Ouest-Versailles-Saint Quentin en Yvelines, Hôpital Ambroise Paré, Boulogne-Billancourt, France; Division of Rheumatology, University of Vienna, Vienna, Austria; Instituto Poal de Reumatologia-Hospital Platon, Barcelona; Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain.M. Szkudlarek, MD, PhD, Department of Rheumatology, Copenhagen University Hospital at Køge; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup; R.J. Wakefield, BM, FRCP, MD, Senior Lecturer and Honorary Consultant Rheumatologist, LIRMM Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital; M. Backhaus, Professor, Dr. Med., Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin; P.V. Balint, MD, PhD, FRCP, Third Department of Rheumatology, Nationa
authors.forename: Peter
authors.initials: P
authors.lastname: Mandl
authors.affiliation: From the Department of Rheumatology, Copenhagen University Hospital at Køge, Køge; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM) Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin, Berlin; Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology, Berlin-Buch, Germany; Third Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Ancona; Rheumatology Unit, Dipartmento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy; Rheumatology Department, Université Paris 6-Pierre et Marie Curie, Hôpital La Pitié Salpetrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris; Rheumatology Department, Université Paris Ouest-Versailles-Saint Quentin en Yvelines, Hôpital Ambroise Paré, Boulogne-Billancourt, France; Division of Rheumatology, University of Vienna, Vienna, Austria; Instituto Poal de Reumatologia-Hospital Platon, Barcelona; Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain.M. Szkudlarek, MD, PhD, Department of Rheumatology, Copenhagen University Hospital at Køge; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup; R.J. Wakefield, BM, FRCP, MD, Senior Lecturer and Honorary Consultant Rheumatologist, LIRMM Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital; M. Backhaus, Professor, Dr. Med., Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin; P.V. Balint, MD, PhD, FRCP, Third Department of Rheumatology, Nationa
authors.forename: Ingrid
authors.initials: I
authors.lastname: Möller
authors.affiliation: From the Department of Rheumatology, Copenhagen University Hospital at Køge, Køge; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM) Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin, Berlin; Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology, Berlin-Buch, Germany; Third Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Ancona; Rheumatology Unit, Dipartmento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy; Rheumatology Department, Université Paris 6-Pierre et Marie Curie, Hôpital La Pitié Salpetrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris; Rheumatology Department, Université Paris Ouest-Versailles-Saint Quentin en Yvelines, Hôpital Ambroise Paré, Boulogne-Billancourt, France; Division of Rheumatology, University of Vienna, Vienna, Austria; Instituto Poal de Reumatologia-Hospital Platon, Barcelona; Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain.M. Szkudlarek, MD, PhD, Department of Rheumatology, Copenhagen University Hospital at Køge; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup; R.J. Wakefield, BM, FRCP, MD, Senior Lecturer and Honorary Consultant Rheumatologist, LIRMM Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital; M. Backhaus, Professor, Dr. Med., Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin; P.V. Balint, MD, PhD, FRCP, Third Department of Rheumatology, Nationa
authors.forename: Esperanza
authors.initials: E
authors.lastname: Naredo
authors.affiliation: From the Department of Rheumatology, Copenhagen University Hospital at Køge, Køge; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM) Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin, Berlin; Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology, Berlin-Buch, Germany; Third Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Ancona; Rheumatology Unit, Dipartmento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy; Rheumatology Department, Université Paris 6-Pierre et Marie Curie, Hôpital La Pitié Salpetrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris; Rheumatology Department, Université Paris Ouest-Versailles-Saint Quentin en Yvelines, Hôpital Ambroise Paré, Boulogne-Billancourt, France; Division of Rheumatology, University of Vienna, Vienna, Austria; Instituto Poal de Reumatologia-Hospital Platon, Barcelona; Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain.M. Szkudlarek, MD, PhD, Department of Rheumatology, Copenhagen University Hospital at Køge; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup; R.J. Wakefield, BM, FRCP, MD, Senior Lecturer and Honorary Consultant Rheumatologist, LIRMM Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital; M. Backhaus, Professor, Dr. Med., Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin; P.V. Balint, MD, PhD, FRCP, Third Department of Rheumatology, Nationa
authors.forename: Wolfgang A
authors.initials: WA
authors.lastname: Schmidt
authors.affiliation: From the Department of Rheumatology, Copenhagen University Hospital at Køge, Køge; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark; Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM) Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Leeds, UK; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin, Berlin; Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology, Berlin-Buch, Germany; Third Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Ancona; Rheumatology Unit, Dipartmento Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy; Rheumatology Department, Université Paris 6-Pierre et Marie Curie, Hôpital La Pitié Salpetrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris; Rheumatology Department, Université Paris Ouest-Versailles-Saint Quentin en Yvelines, Hôpital Ambroise Paré, Boulogne-Billancourt, France; Division of Rheumatology, University of Vienna, Vienna, Austria; Instituto Poal de Reumatologia-Hospital Platon, Barcelona; Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain.M. Szkudlarek, MD, PhD, Department of Rheumatology, Copenhagen University Hospital at Køge; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup; R.J. Wakefield, BM, FRCP, MD, Senior Lecturer and Honorary Consultant Rheumatologist, LIRMM Section of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital; M. Backhaus, Professor, Dr. Med., Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin; P.V. Balint, MD, PhD, FRCP, Third Department of Rheumatology, Nationa
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: d'Agostino
mesh_terms: D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000473:pathology*; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000473:pathology*; D003430:Cross-Sectional Studies; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018608:Ultrasonography, Doppler / Q000379:methods*
keywords: BONE EROSIONS; RHEUMATOID ARTHRITIS; SYSTEMATIC REVIEW; ULTRASOUND