title: MRI-Guided Delivery of Viral Vectors.
abstract: Gene therapy has emerged as a potential avenue of treatment for many neurological disorders. Technological advances in imaging techniques allow for the monitoring of real-time infusions into the brain of rodents, nonhuman primates, and humans. Here, we discuss the use of magnetic resonance imaging (MRI) as a tool in the delivery of adeno-associated viral (AAV) particles into brain of nonhuman primates.
authors.affiliation: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, 94103-0555, USA.|Laboratory for CNS Repair, Brain and Spinal Cord Injury Center, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, 94110, USA.
authors.forename: Ernesto A
authors.initials: EA
authors.lastname: Salegio
authors.affiliation: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, 94103-0555, USA.
authors.forename: John
authors.initials: J
authors.lastname: Bringas
authors.affiliation: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, 94103-0555, USA. krystof.bankiewicz@ucsf.edu.
authors.forename: Krystof S
authors.initials: KS
authors.lastname: Bankiewicz
mesh_terms: D000818:Animals; D001921:Brain / Q000821:virology*; D000229:Dependovirus / Q000235:genetics; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors / Q000008:administration & dosage*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods
keywords: AAV; Gene therapy; MRI; Nonhuman primates; Preclinical