title: Novel Delivery Routes for Allergy Immunotherapy: Intralymphatic, Epicutaneous, and Intradermal.
abstract: Current allergy immunotherapy protocols suffer from two main problems: long treatment duration and systemic allergic side effects of the allergen administrations. The immunologic effects of allergen administration could be enhanced and the number of allergen administrations and treatment duration reduced by choosing a tissue for administration that contains a high density of antigen-presenting cells. Local side effects could be reduced by choosing a route characterized by a low density of mast cells, and systemic side effects could be reduced by administration to nonvascularized tissues, so that inadvertent systemic distribution of the allergen and consequent systemic allergic side effects are minimized.
authors.affiliation: Clinical Trials Center, University Hospital Zurich, Moussonstrasse 2, Zurich 8044, Switzerland.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Senti
authors.affiliation: Department of Dermatology, University Hospital Zurich, Gloriatrasse 31, Zurich 8091, Switzerland. Electronic address: thomas.kuendig@usz.ch.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Kündig
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D003888:Desensitization, Immunologic; D004333:Drug Administration Routes; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000628:therapy*; D008198:Lymph Nodes / Q000098:blood supply / Q000276:immunology*; D012867:Skin / Q000098:blood supply / Q000276:immunology*
keywords: Epicutaneous allergy immunotherapy; Food allergy; Respiratory allergy; Transcutaneous allergy immunotherapy