title: Intraindividual Variability of Nonmotor Fluctuations in Advanced Parkinson's Disease.
abstract: Nonmotor symptoms (NMS) fluctuate in conjunction with motor oscillations in advanced Parkinson's disease (PD), though little is known about the variability of NMS fluctuations in individual patients. We aimed to assess within-patient variability in frequency and severity of NMS during a series of five patient-perceived motor On and Off periods in 38 fluctuating PD patients from the multicenter NonMotorFluctuations in PD study using a visual analogue scale. NMS frequency and severity appeared moderately variable in both motor states within individual patients. Symptom severity ranges between motor states showed high variability and were larger in motor Off states for most NMS.
authors.affiliation: Division of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
authors.forename: Mareike
authors.initials: M
authors.lastname: Fauser
authors.affiliation: Division of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.|Department of Neurology, University of Rostock, Rostock, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Löhle
authors.affiliation: Movement Disorders Clinic, Beelitz-Heilstätten, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Ebersbach
authors.affiliation: Department of Neurology, Klinikum Bremerhaven, Bremerhaven, Germany.|Department of Neurology, University Hospital, Lund, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Odin
authors.affiliation: Parkinson Clinic Wolfach, Wolfach, Germany.
authors.forename: Gerd
authors.initials: G
authors.lastname: Fuchs
authors.affiliation: Parkinson Clinic Wolfach, Wolfach, Germany.
authors.forename: Wolfgang H
authors.initials: WH
authors.lastname: Jost
authors.affiliation: National Parkinson Foundation Centre of Excellence, Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, UK.
authors.forename: K Ray
authors.initials: KR
authors.lastname: Chaudhuri
authors.affiliation: Department of Medical Informatics and Biometry, Technische Universität Dresden, Dresden, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Koch
authors.affiliation: Division of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.|Department of Neurology, University of Rostock, Rostock, Germany.|German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Storch
mesh_terms: D000368:Aged; D018450:Disease Progression; D005260:Female; D006801:Humans; D007206:Individuality; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*; D012720:Severity of Illness Index
keywords: NMS domains; Nonmotor symptoms; Parkinson’s disease; intraindividual variability; nonmotor fluctuations