title: Effect of granulocyte colony stimulating EPC on cardiac function and myocardial energy expenditure in patients with heart failure after myocardial infarction.
abstract: OBJECTIVE
  To study the changes of cardiac function and myocardial energy expenditure following treatment with granulocyte colony stimulating factor (G-CSF) in patients with heart failure after myocardial infarction.
  
  
  METHODS
  Thirty-eight patients with heart failure after myocardial infarction were randomized into G-CSF treatment group and control group. All the patients received conventional treatment (medication and interventional therapy), and the patients in treatment group were given additional G-CSF (600 μg/day) for 7 consecutive days. The plasma level of brain-type natriuretic peptide (BNP) and the number of endothelial progenitor cells (EPC) in the peripheral blood were detected before and at 7 days and 4 months after the treatment. The cardiac functions (LVEF, FS, LVIDs, PWTs, EDV, SV, ET) was evaluated by ultrasonic imaging before and at 2 weeks and 4 months after the treatment. The MEE and circumferential end-systolic wall stress (cESS) were calculated by correlation formula.
  
  
  RESULTS
  The number of EPC was significantly higher in the treatment group than in the control group after the treatment especially at 7 days (P<0.01). In both groups, BNP level was lowered significantly after the treatment to recover the normal level (P<0.01). The cardiac functions and myocardial energy expenditure were improved in all the patients at 2 weeks and 4 months after the treatment, and the improvement was more obvious in the treatment group (P<0.05), especially in terms of the MEE and cESS was significantly lowered in the treatment group than in the control group after the treatment at 2 weeks (P<0.01), the LVEF and FS was significantly increased in the treatment group than in the control group after the treatment at 4 months (P<0.01).
  
  
  CONCLUSIONS
  EPC mobilization by G-CSF can effectively improve the cardiac functions, lessen ventricular remodeling and reduce myocardial energy expenditure in patients with heart failure after myocardial infarction.
authors.affiliation: Department of Cardiology, PLA 303 Hospital China.
authors.forename: Zilin
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, PLA 303 Hospital China.
authors.forename: Jianchun
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Cardiology, PLA 303 Hospital China.
authors.forename: Lixian
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Cardiology, PLA 303 Hospital China.
authors.forename: Xia
authors.initials: X
authors.lastname: Luo
authors.affiliation: Department of Cardiology, PLA 303 Hospital China.
authors.forename: Liangyan
authors.initials: L
authors.lastname: Huang
keywords: Endothelial progenitor cells; cardiac function; granulocyte colony stimulating factor; heart failure; myocardial energy expenditure; myocardial infarction