title: Serum Glutathione in Patients with Schizophrenia in Dynamics of Antipsychotic Therapy.
abstract: Serum concentrations of oxidized and reduced glutathione were measured in 73 patients with schizophrenia at admission and in dynamics of therapy with traditional and atypical antipsychotic drugs. The level of reduced glutathione in patients with schizophrenia with manifest clinical symptoms was lower than in normal subjects. Atypical neuroleptics produced virtually no effects on the glutathione system, while therapy with typical antipsychotics led to further decrease in the levels of reduced glutathione, thus aggravating the imbalance of metabolic processes typical of schizophrenia.
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia. svetlana@mail.omsknet.ru.|National Research Tomsk Polytechnological University, Tomsk, Russia. svetlana@mail.omsknet.ru.
authors.forename: S A
authors.initials: SA
authors.lastname: Ivanova
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.
authors.forename: L P
authors.initials: LP
authors.lastname: Smirnova
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.
authors.forename: Yu G
authors.initials: YG
authors.lastname: Shchigoreva
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Semke
authors.affiliation: Research Institute of Mental Health, Tomsk, Russia.|National Research Tomsk University, Tomsk, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Bokhan
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005260:Female; D005978:Glutathione / Q000097:blood*; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D005978:Glutathione
keywords: antipsychotic drugs; reduced glutathione; schizophrenia