title: Effect of Age and Refractive Error on the Melanopsin Mediated Post-Illumination Pupil Response (PIPR).
abstract: Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR). Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function. Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors. We show that there is no effect of age or refractive error on ipRGC inputs to the human pupil control pathway. The stability of the ipRGC mediated pupil response across the human lifespan provides a functional correlate of their robustness observed during ageing in rodent models.
authors.affiliation: Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Brisbane QLD 4059, Australia.
authors.forename: Prakash
authors.initials: P
authors.lastname: Adhikari
authors.affiliation: Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Brisbane QLD 4059, Australia.
authors.forename: Candice A
authors.initials: CA
authors.lastname: Pearson
authors.affiliation: Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Brisbane QLD 4059, Australia.
authors.forename: Alexandra M
authors.initials: AM
authors.lastname: Anderson
authors.affiliation: Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Brisbane QLD 4059, Australia.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Zele
authors.affiliation: Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Brisbane QLD 4059, Australia.|Queensland Eye Institute, South Brisbane QLD, Australia.
authors.forename: Beatrix
authors.initials: B
authors.lastname: Feigl
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012025:Reflex, Pupillary; D012030:Refractive Errors / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000378:metabolism* / Q000473:pathology; D017299:Rod Opsins / Q000378:metabolism*; D000099210:Melanopsin
chemical_list: D017299:Rod Opsins; D000099210:Melanopsin