title: Association of polymorphisms in translesion synthesis genes with prognosis of advanced non-small-cell lung cancer patients treated with platinum-based chemotherapy.
abstract: OBJECTIVE
  Translesion synthesis (TLS) polymerases enable cells to bypass or overcome DNA damage during DNA replication and contributes to genomic instability and cancer. Inhibition of the expression of TLS genes enhances the sensitivity of cancer cells to cisplatin. This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) in the TLS genes and clinical outcome of advanced non-small-cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy.
  
  
  METHODS
  A total of 16 SNPs were genotyped and analyzed in 302 advanced NSCLC patients (discovery set), and the results were further validated in additional 428 NSCLC patients (validation set).
  
  
  RESULTS
  Analyses revealed significant associations of two SNPs, rs3213801 and rs3792136, with overall survival, with the lowest combined P values of 0.003 and 0.016, respectively. These effects also remained in stratification analyses by clinical variables. Furthermore, the number of risk genotypes of the two SNPs showed a cumulative effect on overall survival (P = 0.03).
  
  
  CONCLUSIONS
  Genetic polymorphisms in the TLS genes might serve as potential predictive biomarkers of prognosis of advanced NSCLC patients treated with platinum-based chemotherapy.
authors.affiliation: Department of Thoracic Surgery, Taizhou Central Hospital, Taizhou, Zhejiang, China.
authors.forename: Xuelin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Fuzhou Pulmonary Hospital, Fujian Medical University, Fuzhou, Fujian, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Chen
authors.affiliation: School of Medical Laboratory Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Surgical Oncology, Taizhou Central Hospital, Taizhou, Zhejiang, China.
authors.forename: Chunya
authors.initials: C
authors.lastname: He
authors.affiliation: Department of Thoracic Surgery, Taizhou Central Hospital, Taizhou, Zhejiang, China.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Mao
authors.affiliation: Department of Surgical Oncology, Taizhou Central Hospital, Taizhou, Zhejiang, China.
authors.forename: Yuechu
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Respiratory Medicine, Taizhou Central Hospital, Taizhou, Zhejiang, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Respiratory Medicine, Taizhou Central Hospital, Taizhou, Zhejiang, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Hu
authors.affiliation: Department of Radiotherapy, Taizhou Central Hospital, Taizhou, Zhejiang, China.
authors.forename: Chengchu
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Department of Radiotherapy, Taizhou Central Hospital, Taizhou, Zhejiang, China.|Department of Thoracic Surgery, Taizhou Hospital, Taizhou, Zhejiang, China.
authors.forename: Baofu
authors.initials: B
authors.lastname: Chen
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000235:genetics; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000235:genetics; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D034702:RNA-Binding Protein FUS / Q000235:genetics*
chemical_list: D034702:RNA-Binding Protein FUS; D002945:Cisplatin
keywords: chemotherapy; lung cancer; platinum; single nucleotide polymorphism; translesion DNA synthesis