title: Giant Centrifugal and Necrotizing Cutaneous Metastases of Melanoma: A Brief Review of the Literature and a Case Report.
abstract: BACKGROUND
  Melanoma is a neoplasm derived from melanocytes of the skin and other sites. In the natural history of melanoma, cutaneous metastases occur relatively frequently and can arise in early or late stages of the disease.
  
  
  OBJECTIVE
  Melanoma skin metastases have a variable appearance. Several clinical appearances are described in the literature.
  
  
  CONCLUSIONS
  We describe an unusual clinical pattern of cutaneous melanoma metastasis, defined as giant, centrifugal, and necrotizing, and we provide a brief review of the literature.
authors.affiliation: Dermatology and Venereology Department, University of Trieste, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: di Meo
authors.affiliation: Dermatology and Venereology Department, University of Trieste, Italy katiuscia.nan@gmail.com.
authors.forename: Katiuscia
authors.initials: K
authors.lastname: Nan
authors.affiliation: Dermatology and Venereology Department, University of Trieste, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Vichi
authors.affiliation: Dermatology and Venereology Department, University of Trieste, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Gatti
authors.affiliation: Dermatology and Venereology Department, University of Trieste, Italy.
authors.forename: Giusto
authors.initials: G
authors.lastname: Trevisan
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000556:secondary*; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary*; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D008545:Melanoma / Q000150:complications / Q000556:secondary*; D009336:Necrosis / Q000209:etiology; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology* / Q000556:secondary*
keywords: cancer; dermatology; melanoma