title: Pleural synovial sarcoma patient treated with combined chemotherapy and Endostar, plus sunitinib maintenance therapy: A case report and review of the literature.
abstract: Synovial sarcoma is a rare, highly malignant soft-tissue tumor that occurs primarily in the extremities. At present, there is no effective clinical treatment for this condition. The present study reports the case of a 49-year-old male who was diagnosed with pleural synovial sarcoma and treated with recombinant human endostatin (Endostar) combined with chemotherapy for a total of six cycles, followed by sunitinib maintenance therapy. To the best of our knowledge, this is the first reported use of sunitinib for maintenance therapy in pleural synovial sarcoma. The patient survived for 25 months after the recurrence of the disease following surgery. The results indicate that this combination therapy was effective in the treatment of pleural synovial sarcoma. The present study also briefly reviews the literature on pleural synovial sarcoma, and the features and treatments for this rare case are discussed.
authors.affiliation: Department of Oncology, The Second Affiliated Clinical Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
authors.forename: Chong
authors.initials: C
authors.lastname: Teng
authors.affiliation: Department of Oncology, The Second Affiliated Clinical Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
authors.forename: L I
authors.initials: LI
authors.lastname: Li
authors.affiliation: Department of Oncology, The Second Affiliated Clinical Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
authors.forename: Weixi
authors.initials: W
authors.lastname: Shen
authors.affiliation: Heilongjiang Academy of Chinese Medicine, Harbin, Heilongjiang 150001, P.R. China.
authors.forename: Jingang
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Oncology, The Second Affiliated Clinical Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Oncology, The Second Affiliated Clinical Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
authors.forename: Qiuying
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Department of Oncology, The Second Affiliated Clinical Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xin
authors.affiliation: Department of Oncology, The Second Affiliated Clinical Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
authors.forename: Dayong
authors.initials: D
authors.lastname: Huang
authors.affiliation: Department of Oncology, The Second Affiliated Clinical Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Oncology, The Second Affiliated Clinical Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
authors.forename: Yanju
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Department of Oncology, The Second Affiliated Clinical Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Jin
keywords: Endostar; chemotherapy; pleura; sunitinib; synovial sarcoma