title: Total Syntheses and Biological Evaluation of (±)-Botryosphaeridione, (±)-Pleodendione, 4-epi-Periconianone B, and Analogues.
abstract: The total syntheses of (±)-botryosphaeridione, (±)-pleodendione, (±)-hoaensieremodione, 4-epi-periconianone B, and their analogues have been accomplished for the first time. All the synthesized target compounds were screened in neural anti-inflammatory assays using LPS induced microglia cells (N9). Among them, compounds 1 and 21 were identified as potential lead compounds for further profiling.
authors.affiliation: CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune 411008, India.
authors.forename: Kishor L
authors.initials: KL
authors.lastname: Handore
authors.affiliation: CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune 411008, India.
authors.forename: Prakash D
authors.initials: PD
authors.lastname: Jadhav
authors.affiliation: National Brain Research Centre , NH-8, Manesar, Gurgaon, Haryana-122051, India.
authors.forename: Bibhabasu
authors.initials: B
authors.lastname: Hazra
authors.affiliation: National Brain Research Centre , NH-8, Manesar, Gurgaon, Haryana-122051, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Basu
authors.affiliation: CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune 411008, India.
authors.forename: D Srinivasa
authors.initials: DS
authors.lastname: Reddy
keywords: Natural product; antineuroinflammatory agents; botryosphaeridione; pleodendione; total synthesis