title: LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals.
abstract: Neuroinflammation is an important feature in the pathogenesis and progression of neurodegenerative diseases such as Alzheimer´s disease (AD), Parkinson´s disease (PD), frontotemporal dementia and amyotrophic lateral sclerosis. Based on current knowledge in the field, suggesting that targeting peripheral inflammation could be a promising additional treatment/prevention approach for neurodegenerative diseases, drugs and natural products with anti-inflammatory properties have been evaluated in animal models of neuroinflammation and neurodegeneration. In this review, we provide an extensive analysis of one of the most important and widely-used animal models of peripherally induced neuroinflammation and neurodegeneration - lipopolysaccharide (LPS)-treated mice, and address the data reproducibility in published research. We also summarize briefly basic features of various natural products, nutraceuticals, with known anti-inflammatory effects and present an overview of data on their therapeutic potential for reducing neuroinflammation in LPS-treated mice.
authors.forename: Miryam Nava
authors.initials: MN
authors.lastname: Catorce
authors.affiliation: Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico (UNAM), Apartado Postal 70228, Cuidad Universitaria, Mexico DF, CP 04510, Mexico. gokar@unam.mx.
authors.forename: Goar
authors.initials: G
authors.lastname: Gevorkian
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001253:Astrocytes / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004660:Encephalitis / Q000139:chemically induced / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control*; D008070:Lipopolysaccharides / Q000008:administration & dosage*; D051379:Mice; D017628:Microglia / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000150:complications*; D015203:Reproducibility of Results
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides