title: Gold-Catalyzed C-H Annulation of Anthranils with Alkynes: A Facile, Flexible, and Atom-Economical Synthesis of Unprotected 7-Acylindoles.
abstract: The gold-catalyzed C-H annulation of anthranil derivatives with alkynes offers a facile, flexible, and atom-economical one-step route to unprotected 7-acylindoles. An intermediate α-imino gold carbene, generated by an intermolecular reaction, promotes ortho-aryl C-H functionalization to afford the target products. The transformation proceeds with a broad range of substrates under mild conditions. Moreover, the obtained functionalized indole products represent a versatile platform for the construction of diverse indolyl frameworks.
authors.affiliation: Institut für Organische Chemie, Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg (Germany).
authors.forename: Hongming
authors.initials: H
authors.lastname: Jin
authors.affiliation: Institut für Organische Chemie, Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg (Germany).
authors.forename: Long
authors.initials: L
authors.lastname: Huang
authors.affiliation: Institut für Organische Chemie, Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg (Germany).
authors.forename: Jin
authors.initials: J
authors.lastname: Xie
authors.affiliation: Institut für Organische Chemie, Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg (Germany).
authors.forename: Matthias
authors.initials: M
authors.lastname: Rudolph
authors.affiliation: Institut für Organische Chemie, Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg (Germany).
authors.forename: Frank
authors.initials: F
authors.lastname: Rominger
authors.affiliation: Institut für Organische Chemie, Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg (Germany). hashmi@hashmi.de.|Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. hashmi@hashmi.de.
authors.forename: A Stephen K
authors.initials: AS
authors.lastname: Hashmi
keywords: CH functionalization; alkynes; gold carbenoids; gold catalysis; indoles