title: Low MiR-149 expression is associated with unfavorable prognosis and enhanced Akt/mTOR signaling in glioma.
abstract: MicroRNAs (miRs) play critical roles in the progression of glioma. Previous in vitro studies have described the anti-tumor role of miR-149 in cancer cells including glioma. In this study, we aimed to investigate whether miR-149 is associated with the prognosis of glioma patients. A total of 163 glioma patients who underwent tumor resection were included in our follow-up study. We found that the miR-149 expression was significantly lower in tumor tissues compared with that in normal tissues (P<0.05). Kaplan-Meier and analysis showed that the miR-149 expression status was significantly associated with the survival duration (logrank test, P<0.001), and multivariate Cox regression revealed that patients with low miR-149 expression were exposed to a 1.825 fold higher death risk (HR=1.825, 95% CI=1.031-3.229, P=0.039) compared with those with high miR-149 expression. Further study showed that Akt/mTOR signaling was hyperactive in low miR-149 expressing tissues. Our study thus demonstrates that miR-149 expression in glioma tissues is critically associated with the prognosis of patients, suggesting its potential clinical significance.
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital Tianjin 300052, P. R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Xue
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital Tianjin 300052, P. R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital Tianjin 300052, P. R. China.
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Yue
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital Tianjin 300052, P. R. China.
authors.forename: Jianning
authors.initials: J
authors.lastname: Zhang
mesh_terms: D016009:Chi-Square Distribution; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000201:enzymology* / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D015999:Multivariate Analysis; D010766:Phosphorylation; D011379:Prognosis; D016016:Proportional Hazards Models; D051057:Proto-Oncogene Proteins c-akt / Q000032:analysis*; D018570:Risk Assessment; D012307:Risk Factors; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000032:analysis*; D013997:Time Factors
chemical_list: C551557:MIRN149 microRNA, human; D035683:MicroRNAs; C546842:MTOR protein, human; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases
keywords: Akt; Glioma; mTOR; miR-149; prognosis