title: NEURODEM: assessment of the iatrogenic alert indicator for nursing home patients with Alzheimer's or Alzheimer-like disease.
abstract: BACKGROUND
  Neuroleptics are known to induce Parkinsonism, tardive dyskinesia and their long-term use was associated with increased risk of hip fractures and impaired cognitive function and even death.
  
  
  METHODS
  The primary objective of Neurodem study was to determine the IAI of patients with Alzheimer's disease in French NH.
  
  
  RESULTS
  1022 patients were enrolled. The IAI was 24.8 %. Multivariate logistic analysis showed that having a severe form of dementia, resident without MMS evaluation the last 12 months and having a prescription for an anxiolytic drug were associated with a higher risk of having a prescription for an antipsychotic drug.
  
  
  CONCLUSIONS
  The results from our study show that the percentage of patients receiving an antipsychotic drug (24.8 %) was higher than the national average (18 %). Effective educational activities about appropriate use of antipsychotic drugs in patients with Alzheimer's disease are needed.
authors.affiliation: University Hospital Center of Angers, 4 Rue Larrey, 49100, Angers, France. Samir.henni@gmail.com.|AGREE, 8 Brairon, 44690, Château Thebaud, France. Samir.henni@gmail.com.
authors.forename: Samir
authors.initials: S
authors.lastname: Henni
authors.affiliation: AGREE, 8 Brairon, 44690, Château Thebaud, France.
authors.forename: Florence Delamarre
authors.initials: FD
authors.lastname: Damier
authors.affiliation: AGREE, 8 Brairon, 44690, Château Thebaud, France.|Pôle de Gérontologie Clinique, CHU Nantes, Hôpital Bellier, 41 Rue Curie, 44046, Nantes Cedex 1, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Sonnic
authors.affiliation: AGREE, 8 Brairon, 44690, Château Thebaud, France.|Pharmacie Hôpital Sèvre ET Loire, 44120, Vertou, France.
authors.forename: Gwennaelle
authors.initials: G
authors.lastname: Feinard
authors.affiliation: AGREE, 8 Brairon, 44690, Château Thebaud, France.|Pôle de Gérontologie Clinique, CHU Nantes, Hôpital Bellier, 41 Rue Curie, 44046, Nantes Cedex 1, France.|Clinical Pharmacology Department, Institute of Biology, University Hospital, Nantes, France.
authors.forename: Gwennäelle
authors.initials: G
authors.lastname: Veyrac
authors.affiliation: AGREE, 8 Brairon, 44690, Château Thebaud, France.|, 27 Les Essarts Nursing Home, Rue Des Hirondelles, 85140, Les Essarts, France.
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Pujol
authors.affiliation: AGREE, 8 Brairon, 44690, Château Thebaud, France.|Pôle de Gérontologie Clinique, CHU Nantes, Hôpital Bellier, 41 Rue Curie, 44046, Nantes Cedex 1, France.
authors.forename: Laure
authors.initials: L
authors.lastname: de Decker
authors.affiliation: AGREE, 8 Brairon, 44690, Château Thebaud, France.|Pôle de Gérontologie Clinique, CHU Nantes, Hôpital Bellier, 41 Rue Curie, 44046, Nantes Cedex 1, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Berrut
authors.affiliation: AGREE, 8 Brairon, 44690, Château Thebaud, France.|Pharmacie Hôpital Sèvre ET Loire, 44120, Vertou, France.|Faculté de Pharmacie, Université de Nantes, 9, Rue Bias BP53508, 44035, Nantes Cedex 1, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Piessard
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003704:Dementia / Q000188:drug therapy; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D009735:Nursing Homes
chemical_list: D014150:Antipsychotic Agents
keywords: Alzheimer’s disease; Neuroleptic drug prescription; Neuropsychiatric symptoms; Nursing home