title: Expression of Cyclooxygenase-2 in naturally occurring bovine cutaneous fibropapillomas.
abstract: Bovine cutaneous fibropapillomas are benign skin tumours characterized by epithelial and dermal proliferation and induced by Bovine papillomaviruses (BPVs). Cyclooxygenase (COX) 1 and 2 are enzymes involved in pathological conditions, such as inflammation and epithelial carcinogenesis. Here we investigated biochemically and immunohistochemically COX-2 expression in bovine cutaneous fibropapillomas. Eight of twelve fibropapillomas (67%) showed COX-2 positive immunosignal mostly in the cytoplasm of the basal cell layer, while the normal skin did not stain. Biochemical analysis confirmed the expression of COX-2 in tumour samples. This study shows COX-2 expression in cutaneous fibropapillomas, suggesting a contribution in epithelial tumour development.
authors.forename: F
authors.initials: F
authors.lastname: Bocaneti
authors.forename: G
authors.initials: G
authors.lastname: Altamura
authors.forename: A
authors.initials: A
authors.lastname: Corteggio
authors.forename: C
authors.initials: C
authors.lastname: Solcan
authors.forename: E
authors.initials: E
authors.lastname: Velescu
authors.forename: G
authors.initials: G
authors.lastname: Borzacchiello
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism*; D052687:Deltapapillomavirus; D030361:Papillomavirus Infections / Q000201:enzymology / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D017193:Skin Diseases, Viral / Q000201:enzymology / Q000378:metabolism / Q000662:veterinary*
chemical_list: D051546:Cyclooxygenase 2