title: A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats.
abstract: Simiaowan (SMW) is a famous Chinese prescription widely used in clinical treatment of rheumatoid arthritis (RA). The aim of the present study is to determine novel biomarkers to increase the current understanding of RA mechanisms, as well as the underlying therapeutic mechanism of SMW, in RA-model rats. Plasma extracts from control, RA model, and SMW-treated rats were analyzed by gas chromatography coupled with mass spectrometry (GC-MS). An orthogonal partial least-square discriminant analysis (OPLS-DA) model was created to detect metabolites that were expressed in significantly different amounts between the RA model and the control rats and investigate the therapeutic effect of SMW. Metabonomics may prove to be a valuable tool for determining the efficacy of complex traditional prescriptions.
authors.affiliation: School of Traditional Chinese Materia Medica, Tianjin University of TCM, 312 Anshan West Road, Nankai District, Tianjin 300193, China. wangyuming226@163.com.|Tianjin State Key Laboratory of Modern Chinese Medicine, No. 88, Yuquan Road, Nankai District, Tianjin 300193, China. wangyuming226@163.com.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Traditional Chinese Materia Medica, Tianjin University of TCM, 312 Anshan West Road, Nankai District, Tianjin 300193, China. guoxuejung666@126.com.|Tianjin State Key Laboratory of Modern Chinese Medicine, No. 88, Yuquan Road, Nankai District, Tianjin 300193, China. guoxuejung666@126.com.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Guo
authors.affiliation: School of Traditional Chinese Materia Medica, Tianjin University of TCM, 312 Anshan West Road, Nankai District, Tianjin 300193, China. 18600893359@163.com.|Tianjin State Key Laboratory of Modern Chinese Medicine, No. 88, Yuquan Road, Nankai District, Tianjin 300193, China. 18600893359@163.com.
authors.forename: Jiabin
authors.initials: J
authors.lastname: Xie
authors.affiliation: School of Traditional Chinese Materia Medica, Tianjin University of TCM, 312 Anshan West Road, Nankai District, Tianjin 300193, China. hzgssh@163.com.|Tianjin State Key Laboratory of Modern Chinese Medicine, No. 88, Yuquan Road, Nankai District, Tianjin 300193, China. hzgssh@163.com.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Hou
authors.affiliation: School of Traditional Chinese Materia Medica, Tianjin University of TCM, 312 Anshan West Road, Nankai District, Tianjin 300193, China. yaowufenxi001@sina.com.|Tianjin State Key Laboratory of Modern Chinese Medicine, No. 88, Yuquan Road, Nankai District, Tianjin 300193, China. yaowufenxi001@sina.com.
authors.forename: Yubo
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D016002:Discriminant Analysis; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D016018:Least-Squares Analysis; D008297:Male; D055432:Metabolomics; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015415:Biomarkers; D004365:Drugs, Chinese Herbal; C000590843:simiaowan
keywords: GC-MS; Simiaowan; metabonomics; rheumatoid arthritis