title: MicroRNAs and Endothelial (Dys) Function.
abstract: Accumulating evidence indicates that microRNAs (miRs)-non-coding RNAs that can regulate gene expression via translational repression and/or post-transcriptional degradation-are becoming one of the most fascinating areas of physiology, given their fundamental roles in countless pathophysiological processes. The relative roles of different miRs in vascular biology as direct or indirect post-transcriptional regulators of fundamental genes implied in vascular remodeling designate miRs as potential biomarkers and/or promising drug targets. The mechanistic importance of miRs in modulating endothelial cell (EC) function in physiology and in disease is addressed here. Drawbacks of currently available therapeutic options are also discussed, pointing at the challenges and clinical opportunities provided by miR-based treatments. J. Cell. Physiol. 231: 1638-1644, 2016. © 2015 Wiley Periodicals, Inc.
authors.affiliation: Columbia University Medical Center, New York Presbyterian Hospital-Manhattan, New York, New York.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Santulli
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000503:physiopathology; D005786:Gene Expression Regulation; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use; D018919:Neovascularization, Physiologic; D015398:Signal Transduction
chemical_list: C527111:MIRN126 microRNA, human; D035683:MicroRNAs