title: Medulloblastoma with soft-tissue and skeletal metastases in an adult: A case report.
abstract: Medulloblastoma (MB) is a highly malignant primary brain tumor, which occurs in the cerebellum or posterior cranial fossa. MB is most commonly identified in children <10 years of age. The disease is rare in adults, affecting patients aged between 30 and 50 years of age, with an incidence of 0.5 cases per 1,000,000 individuals. Extraneural metastases are reported in 7-10% of cases, most commonly involving the bones and more rarely involving the lymph nodes, visceral organs and bone marrow. The current study presents the case of a 36-year-old male who underwent a gross total resection followed by radiation therapy to the craniospinal axis for the treatment of MB. The patient subsequently developed widespread metastasis, which involved the soft tissue of the occipital bone. Subsequently, the patient was administered palliative radiotherapy and initially exhibited a good clinical response. However, the patient succumbed at 18 months post-diagnosis due to dissemination of the disease. The literature on the extraneural metastasis of MB is also reviewed in the current study.
authors.affiliation: Department of Oncology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.
authors.forename: Dianzhong
authors.initials: D
authors.lastname: Geng
authors.affiliation: Department of Obstetrics and Gynecology, Binzhou People's Hospital, Binzhou, Shandong 256610, P.R. China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Regular Physical Examination Centre, Binzhou People's Hospital, Binzhou, Shandong 256610, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Oncology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.
authors.forename: Zeshun
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Department of Oncology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.
authors.forename: Fangling
authors.initials: F
authors.lastname: Ning
keywords: adult; extraneural; medulloblastoma; skeletal metastases