title: A meta-analysis of the relationship between vitamin D deficiency and obesity.
abstract: Previous epidemiologic studies suggested that vitamin D deficiency may be a risk factor of obesity. However, the result is still controversial. This meta-analysis aims to provide a comprehensive summary on the association between vitamin D deficiency and obesity. We systematically searched Pubmed database, Chinese Wanfang Data Knowledge Service Platform, and Chinese National Knowledge Infrastructure (CNKI), for the literatures on the relationship between vitamin D deficiency and obesity published from 2010 to 2015. The effect sizes of overall odds ratio (OR) and 95% confidence interval (CI) were estimated using Stata 11.0. Heterogeneity was evaluated using random-effects model and forest plots. Fifteen studies were eligible for inclusion in the meta-analysis, which included 3867 subjects with obesity and 9342 health subjects. Meta-analysis results showed that the prevalence of vitamin D deficiency was difference between obesity group and control group, and the pooled OR (95% CI) was 3.43 (2.33-5.06). The prevalence of vitamin D deficiency was associated with obesity in Asians and European-American, OR (95% CI) were 3.70 (1.98-6.90) and 3.09 (1.89-5.04), respectively. No publication bias was found in our study. vitamin D deficiency may be associated with obesity, irrespective of areas.
authors.affiliation: School of Public Health, Wannan Medical College Wuhu 241002, Anhui, China.
authors.forename: Yingshui
authors.initials: Y
authors.lastname: Yao
authors.affiliation: School of Public Health, Wannan Medical College Wuhu 241002, Anhui, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhu
authors.affiliation: School of Public Health, Wannan Medical College Wuhu 241002, Anhui, China.
authors.forename: Lianping
authors.initials: L
authors.lastname: He
authors.affiliation: School of Public Health, Wannan Medical College Wuhu 241002, Anhui, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Duan
authors.affiliation: School of Public Health, Wannan Medical College Wuhu 241002, Anhui, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liang
authors.affiliation: School of Public Health, Wannan Medical College Wuhu 241002, Anhui, China.
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Nie
authors.affiliation: School of Public Health, Wannan Medical College Wuhu 241002, Anhui, China.
authors.forename: Yuelong
authors.initials: Y
authors.lastname: Jin
authors.affiliation: School of Public Health, Wannan Medical College Wuhu 241002, Anhui, China.
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Wu
authors.affiliation: School of Public Health, Wannan Medical College Wuhu 241002, Anhui, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Fang
keywords: Vitamin D; meta-analysis; obesity