title: rcellminer: exploring molecular profiles and drug response of the NCI-60 cell lines in R.
abstract: The rcellminer R package provides a wide range of functionality to help R users access and explore molecular profiling and drug response data for the NCI-60. The package enables flexible programmatic access to CellMiner's unparalleled breadth of NCI-60 data, including gene and protein expression, copy number, whole exome mutations, as well as activity data for ∼21K compounds, with information on their structure, mechanism of action and repeat screens. Functions are available to easily visualize compound structures, activity patterns and molecular feature profiles. Additionally, embedded R Shiny applications allow interactive data exploration.
  
  
  
  rcellminer is compatible with R 3.2 and above on Windows, Mac OS X and Linux. The package, documentation, tutorials and Shiny-based applications are available through Bioconductor (http://www.bioconductor.org/packages/rcellminer); ongoing updates will occur according to the Bioconductor release schedule with new CellMiner data. The package is free and open-source (LGPL 3).
  
  
  
  lunaa@cbio.mskcc.org or vinodh.rajapakse@nih.gov.
authors.affiliation: Computer Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: Augustin
authors.initials: A
authors.lastname: Luna
authors.affiliation: Developmental Therapeutic Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.
authors.forename: Vinodh N
authors.initials: VN
authors.lastname: Rajapakse
authors.affiliation: Centro De Estudos Em Células Tronco, Terapia Celular E Genética Toxicológica, Programa De Pós-Graduação Em Farmácia, Universidade Federal De Mato Grosso Do Sul, Campo Grande, MS 79070-900, Brazil and.
authors.forename: Fabricio G
authors.initials: FG
authors.lastname: Sousa
authors.affiliation: Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: Jianjiong
authors.initials: J
authors.lastname: Gao
authors.affiliation: Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Schultz
authors.affiliation: Developmental Therapeutic Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.
authors.forename: Sudhir
authors.initials: S
authors.lastname: Varma
authors.affiliation: Developmental Therapeutic Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.
authors.forename: William
authors.initials: W
authors.lastname: Reinhold
authors.affiliation: Computer Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Sander
authors.affiliation: Developmental Therapeutic Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.
authors.forename: Yves
authors.initials: Y
authors.lastname: Pommier
mesh_terms: D002460:Cell Line; D040901:Proteomics / Q000379:methods*; D012984:Software