title: Synapsin Isoforms and Synaptic Vesicle Trafficking.
abstract: Synapsins were the first presynaptic proteins identified and have served as the flagship of the presynaptic protein field. Here we review recent studies demonstrating that different members of the synapsin family play different roles at presynaptic terminals employing different types of synaptic vesicles. The structural underpinnings for these functions are just beginning to be understood and should provide a focus for future efforts.
authors.affiliation: Lee Kong Chian School of Medicine, Singapore 637553, Singapore.|Institute of Molecular and Cell Biology, Singapore 138673, Singapore.
authors.forename: Sang-Ho
authors.initials: SH
authors.lastname: Song
authors.affiliation: Lee Kong Chian School of Medicine, Singapore 637553, Singapore.|Institute of Molecular and Cell Biology, Singapore 138673, Singapore.
authors.forename: George J
authors.initials: GJ
authors.lastname: Augustine
mesh_terms: D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism; D010766:Phosphorylation / Q000502:physiology; D017729:Presynaptic Terminals / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology; D016704:Synapsins / Q000378:metabolism*; D013572:Synaptic Vesicles / Q000378:metabolism*
chemical_list: D018377:Neurotransmitter Agents; D020033:Protein Isoforms; D016704:Synapsins
keywords: neurotransmitter release; presynaptic terminals; synapsins; synaptic vesicles; vesicle trafficking