title: Distinguishing between stochasticity and determinism: Examples from cell cycle duration variability.
abstract: We describe a recent approach for distinguishing between stochastic and deterministic sources of variability, focusing on the mammalian cell cycle. Variability between cells is often attributed to stochastic noise, although it may be generated by deterministic components. Interestingly, lineage information can be used to distinguish between variability and determinism. Analysis of correlations within a lineage of the mammalian cell cycle duration revealed its deterministic nature. Here, we discuss the sources of such variability and the possibility that the underlying deterministic process is due to the circadian clock. Finally, we discuss the "kicked cell cycle" model and its implication on the study of the cell cycle in healthy and cancerous tissues.
authors.affiliation: Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University, Jerusalem, Israel.|Department of Microbiology and Molecular Genetics, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem, Israel.
authors.forename: Sivan
authors.initials: S
authors.lastname: Pearl Mizrahi
authors.affiliation: Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Oded
authors.initials: O
authors.lastname: Sandler
authors.affiliation: Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Lande-Diner
authors.affiliation: Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University, Jerusalem, Israel.
authors.forename: Nathalie Q
authors.initials: NQ
authors.lastname: Balaban
authors.affiliation: Department of Microbiology and Molecular Genetics, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem, Israel.
authors.forename: Itamar
authors.initials: I
authors.lastname: Simon
mesh_terms: D002453:Cell Cycle / Q000235:genetics*; D002455:Cell Division / Q000235:genetics*; D019070:Cell Lineage; D006801:Humans; D008962:Models, Theoretical; D009369:Neoplasms / Q000235:genetics*; D013269:Stochastic Processes
keywords: cell cycle; determinism; inheritance; lineage; single cell; stochasticity; variability