title: Persistence of Yellow Fever vaccine-induced antibodies after cord blood stem cell transplant.
abstract: We report the case of a cord blood haematopoietic stem cell transplant recipient who was vaccinated for Yellow Fever (YF) 7 days before initiating chemotherapy and had persistent YF antibodies more than 3 years after vaccination. Since the stem cell donor was never exposed to wild YF or to the YF vaccine, and our patient was not exposed to YF or revaccinated, this finding strongly suggests the persistence of recipient immunity. We briefly discuss potential consequences of incomplete elimination of recipient's leukocytes following existing haematopoietic cancer treatments.
authors.affiliation: a Department of Infectious and Parasitic Diseases , University of Sao Paulo Medical School , Sao Paulo , Brazil.|b Hospital Sirio-Libanes , Sao Paulo , Brazil.
authors.forename: Vivian Iida
authors.initials: VI
authors.lastname: Avelino-Silva
authors.affiliation: c Fundação Oswaldo Cruz , Rio de Janeiro , Brazil.
authors.forename: Marcos da Silva
authors.initials: Mda S
authors.lastname: Freire
authors.affiliation: b Hospital Sirio-Libanes , Sao Paulo , Brazil.
authors.forename: Vanderson
authors.initials: V
authors.lastname: Rocha
authors.affiliation: b Hospital Sirio-Libanes , Sao Paulo , Brazil.
authors.forename: Celso Arrais
authors.initials: CA
authors.lastname: Rodrigues
authors.affiliation: b Hospital Sirio-Libanes , Sao Paulo , Brazil.
authors.forename: Yana Sarkis
authors.initials: YS
authors.lastname: Novis
authors.affiliation: a Department of Infectious and Parasitic Diseases , University of Sao Paulo Medical School , Sao Paulo , Brazil.|d Fundacao Pro-Sangue Hemocentro de Sao Paulo , Sao Paulo , Brazil.
authors.forename: Ester C
authors.initials: EC
authors.lastname: Sabino
authors.affiliation: a Department of Infectious and Parasitic Diseases , University of Sao Paulo Medical School , Sao Paulo , Brazil.|b Hospital Sirio-Libanes , Sao Paulo , Brazil.|e Division of Clinic Immunology and Allergy , University of Sao Paulo Medical School , Sao Paulo , Brazil.
authors.forename: Esper Georges
authors.initials: EG
authors.lastname: Kallas
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D036101:Cord Blood Stem Cell Transplantation; D006801:Humans; D007165:Immunosuppression Therapy; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000628:therapy; D008297:Male; D022341:Yellow Fever Vaccine / Q000276:immunology*; D015005:Yellow fever virus / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D022341:Yellow Fever Vaccine
keywords: cord blood stem cell transplant; immunosuppression; vaccine; yellow fever