title: Similar survival benefits of a good response and stable disease to platinum-based chemotherapy in non-small cell lung cancer.
abstract: The present study aimed to evaluate the similar survival benefits of a good response [complete response or partial response (CR/PR)] and stable disease (SD) to chemotherapy in non-small cell lung cancer (NSCLC) patients in clinical practice. All 322 patients who were treated between 1999 and 2012 with first-line platinum-based chemotherapy were retrospectively analyzed. Tumor responses were classified according to the response evaluation criteria for solid tumors. A total of 67 (20.8%) patients experienced CR/PR and 165 (51.2%) achieved SD. There was no difference in progression-free survival between the patients with CR/PR and those with SD (P=0.347). There was also no difference between the two groups with regard to overall survival time (P=0.878). In multivariate analysis, disease-control (more than SD) was one of the favorable prognostic factors. In clinical practice, a survival benefit would be provided not only for the patients who have good response, but also for those with SD.
authors.affiliation: Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Tamura
authors.affiliation: Division of Respiratory Medicine, Tsukuba Medical Center Hospital, Tsukuba, Ibaraki, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Kurishima
authors.affiliation: Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Nakazawa
authors.affiliation: Division of Respiratory Medicine, Tsukuba Medical Center Hospital, Tsukuba, Ibaraki, Japan.
authors.forename: Hiroichi
authors.initials: H
authors.lastname: Ishikawa
authors.affiliation: Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Satoh
authors.affiliation: Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hizawa
keywords: disease control rate; non-small cell lung cancer; stable disease; survival