title: A Newly Identified Frontal Path from Fornix in Septum Pellucidum with 7.0T MRI Track Density Imaging (TDI) - The Septum Pellucidum Tract (SPT).
abstract: The high anatomical contrast achieved with the newly emerging MRI tractographic technique of super-resolution track density imaging (TDI) encouraged us to search for a new fiber tract in the septum pellucidum. Although this septum pellucidum tract (SPT) has been observed previously, its connections were unclear due to ambiguity and limited resolution of conventional MRI images. It is now possible to identify detailed parts of SPT with the increased resolution of TDI, which involves diffusion MRI imaging, whole-brain tractography, and voxel subdivision using the track-count information. Four healthy male subjects were included in the study. The experiment was performed with 7.0T MRI, following the guidelines of the institute's institutional review board. Data were processed with the super-resolution TDI technique to generate a tractographic map with 0.18 mm isotropic resolution. The SPT was identified in all subjects. Based on additional seed tracking method with inter-axis correlation search, we have succeeded in identifying a new frontal lobe pathway in the SPT. We hypothesize that the tract is connected as a superior dorsal branch of the fornix that leads to the prefrontal cortex.
authors.affiliation: Neuroscience Research Institute, Gachon University of Medicine and Science Incheon, South Korea.
authors.forename: Zang-Hee
authors.initials: ZH
authors.lastname: Cho
authors.affiliation: Neuroscience Research Institute, Gachon University of Medicine and Science Incheon, South Korea ; Department of Pathology, Seoul National University College of Medicine Seoul, South Korea.
authors.forename: Je-Geun
authors.initials: JG
authors.lastname: Chi
authors.affiliation: Neuroscience Research Institute, Gachon University of Medicine and Science Incheon, South Korea.
authors.forename: Sang-Han
authors.initials: SH
authors.lastname: Choi
authors.affiliation: Neuroscience Research Institute, Gachon University of Medicine and Science Incheon, South Korea ; Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia PA, USA.
authors.forename: Se-Hong
authors.initials: SH
authors.lastname: Oh
authors.affiliation: Neuroscience Research Institute, Gachon University of Medicine and Science Incheon, South Korea.
authors.forename: Sung-Yeon
authors.initials: SY
authors.lastname: Park
authors.affiliation: Departments of Neurosurgery, Seoul National University College of Medicine Seoul, South Korea.
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Paek
authors.affiliation: Neuroscience Research Institute, Gachon University of Medicine and Science Incheon, South Korea.
authors.forename: Chan-Woong
authors.initials: CW
authors.lastname: Park
authors.affiliation: The Florey Institute of Neuroscience and Mental Health, Melbourne VIC, Australia ; Department of Medicine, Austin Health and Northern Health, University of Melbourne, Melbourne VIC, Australia.
authors.forename: Fernando
authors.initials: F
authors.lastname: Calamante
authors.affiliation: Neuroscience Research Institute, Gachon University of Medicine and Science Incheon, South Korea.
authors.forename: Young-Bo
authors.initials: YB
authors.lastname: Kim
keywords: 7.0T MRI; diffusion MRI; fiber tracking; fornix; septum pellucidum tract; track density imaging; tractography