title: Implication of lncRNAs in pathogenesis of esophageal cancer.
abstract: Long non-coding RNAs (lncRNAs), transcripts as longer than 200 nt in length with a great number of varieties in human genomics, play important roles in the regulation of genetics and epigenetics including gene transcription and post-transcription. Increasing evidence have demonstrated the upregulation of lncRNAs in tumorigenesis and metastasis of esophageal cancer (EC), a type of malignant tumors particularly in Asia. In this review, we briefly discuss the profiles and functions of lncRNAs involved in the progression of EC, which may provide a new approach to improve EC diagnosis and treatment.
authors.affiliation: Department of Surgical Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Tang
authors.affiliation: Department of Cardiothoracic Surgery, Huaian No 1 People's Hospital, Affiliated to Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Qingquan
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Surgical Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Su-Qing
authors.initials: SQ
authors.lastname: Li
authors.affiliation: Department of Surgical Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Yu-Suo
authors.initials: YS
authors.lastname: Tong
authors.affiliation: Department of Surgical Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Zi-Hao
authors.initials: ZH
authors.lastname: Liu
authors.affiliation: Department of Surgical Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Tong-Xin
authors.initials: TX
authors.lastname: Yang
authors.affiliation: Department of Surgical Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China ; Cancer Center, Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Surgical Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Xiu-Feng
authors.initials: XF
authors.lastname: Cao
keywords: biomarker; esophageal cancer; long non-coding RNAs; review