title: Abiraterone-induced rhabdomyolysis: A case report.
abstract: Abiraterone is an inhibitor of androgen biosynthesis indicated for the treatment of metastatic castration-resistant prostate cancer. Common side effects include diarrhea, edema, hypokalemia, hypertension, and liver function test abnormalities. We report a case of rhabdomyolysis developing in association with the use of abiraterone. Following discontinuation of abiraterone, creatine kinase concentrations decreased gradually throughout the duration of the hospitalization.
authors.affiliation: Southeast Missouri Hospital, Cape Girardeau, MO, USA.
authors.forename: Donald C
authors.initials: DC
authors.lastname: Moore
authors.affiliation: Southeast Missouri Hospital, Cape Girardeau, MO, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Moore
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000736:Androstenes / Q000009:adverse effects* / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols; D003248:Constipation / Q000139:chemically induced* / Q000150:complications; D003402:Creatine Kinase / Q000097:blood; D000072478:Cytochrome P450 Family 17 / Q000037:antagonists & inhibitors; D004359:Drug Therapy, Combination; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D009325:Nausea / Q000209:etiology; D059408:Pain Management / Q000379:methods; D011241:Prednisone / Q000627:therapeutic use; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy*; D012206:Rhabdomyolysis / Q000097:blood / Q000139:chemically induced*; D014839:Vomiting / Q000209:etiology
chemical_list: D000701:Analgesics, Opioid; D000736:Androstenes; D018931:Antineoplastic Agents, Hormonal; D009020:Morphine; D000072478:Cytochrome P450 Family 17; D003402:Creatine Kinase; C089740:abiraterone; D011241:Prednisone
keywords: Abiraterone; rhabdomyolysis; toxicity