title: [Adherence to entecavir for chronic hepatitis B and correlation with effectiveness].
abstract: OBJECTIVE
  to evaluate adherence of patients with chronic hepatitis B initiated on entecavir as first-line treatment and to correlate adherence with effectiveness.
  
  
  METHODS
  observational retrospective study performed between January 2007 and June 2013. Patients treated with entecavir for at least one year were included. A patient was considered to be adherent if median adherence was ≥ 95%. Virological response (HBV DNA < 20UI/ml by Polymerase Chain Reaction), biochemical response (normalized level of alanine amino transferase [AAT]) and serological response (loss of hepatitis B surface antigen [HBsAg]) was assessed at month 12.
  
  
  RESULTS
  85 patients were included. The median adherence rate was 94.2 (SD 12.8)%. 85.7% of the adherent patients achieved a virological response in contrast with 71.4% of the nonadherent patients (OR:2,40; IC95%:0,60-9,54;p = 0,19). 87.9% of the adherent patients and 85.7% of the nonadherent patients showed normalized level of AAT (OR:1,21; IC95%:0,22- 6,60;p = 0,56). Two adherent patients showed clearance of hepatitis B surface antigen.
  
  
  CONCLUSIONS
  the median adherence is not high. Nonadherent patients have a trend towards a higher rate of virological failure so it is necessary to promote improved adherence to treatment.
authors.affiliation: Servicio de Farmacia. Hospital Universitario Ramón y Cajal, Madrid. España.. vanessa.romero@salud.madrid.org.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Romero Díaz-Maroto
authors.affiliation: Servicio de Farmacia. Hospital Universitario Ramón y Cajal, Madrid. España.. mscuervo@salud.madrid.org.
authors.forename: Marina
authors.initials: M
authors.lastname: Sánchez Cuervo
authors.affiliation: Servicio de Farmacia. Hospital Universitario Ramón y Cajal, Madrid. España.. mrsagrado@salud.madrid.org.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Rodríguez Sagrado
authors.affiliation: Servicio de Farmacia. Hospital Universitario Ramón y Cajal, Madrid. España.. tbermejo.hrc@salud.madrid.org.
authors.forename: Teresa
authors.initials: T
authors.lastname: Bermejo Vicedo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D006147:Guanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; C413685:entecavir; D006147:Guanine