title: Scalable lithography from Natural DNA Patterns via polyacrylamide gel.
abstract: A facile strategy for fabricating scalable stamps has been developed using cross-linked polyacrylamide gel (PAMG) that controllably and precisely shrinks and swells with water content. Aligned patterns of natural DNA molecules were prepared by evaporative self-assembly on a PMMA substrate, and were transferred to unsaturated polyester resin (UPR) to form a negative replica. The negative was used to pattern the linear structures onto the surface of water-swollen PAMG, and the pattern sizes on the PAMG stamp were customized by adjusting the water content of the PAMG. As a result, consistent reproduction of DNA patterns could be achieved with feature sizes that can be controlled over the range of 40%-200% of the original pattern dimensions. This methodology is novel and may pave a new avenue for manufacturing stamp-based functional nanostructures in a simple and cost-effective manner on a large scale.
authors.affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.|Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, P.R. China.
authors.forename: JieHao
authors.initials: J
authors.lastname: Qu
authors.affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
authors.forename: XianLiang
authors.initials: X
authors.lastname: Hou
authors.affiliation: Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, P.R. China.
authors.forename: WanChao
authors.initials: W
authors.lastname: Fan
authors.affiliation: Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, P.R. China.
authors.forename: GuangHui
authors.initials: G
authors.lastname: Xi
authors.affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
authors.forename: HongYan
authors.initials: H
authors.lastname: Diao
authors.affiliation: Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, P.R. China.
authors.forename: XiangDon
authors.initials: X
authors.lastname: Liu
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D004247:DNA / Q000737:chemistry*; D021621:Imaging, Three-Dimensional; D018625:Microscopy, Atomic Force; D055620:Optical Phenomena; D011091:Polyesters / Q000737:chemistry; D019904:Polymethyl Methacrylate / Q000737:chemistry; D011327:Printing / Q000379:methods*; D012474:Salmon; D014867:Water / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D011091:Polyesters; C016680:polyacrylamide gels; D014867:Water; D004247:DNA; D019904:Polymethyl Methacrylate