title: Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis.
abstract: Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver disease that is closely related not only to genetic susceptibility but also to insulin resistance and highly linked with metabolic syndrome. In recent years, the prevalence of NAFLD has increased rapidly, paralleling the epidemic of type 2 diabetes mellitus and obesity leading to cardiovascular disease. It has been demonstrated that NAFLD is highly associated with atherosclerosis. With recently gained knowledge, it appears that NAFLD may induce insulin resistance, dyslipidemia, oxidative stress, inflammation, and fluctuation of adipokines associated with atherosclerosis. In this review, we aimed to summarize recent discoveries related to both NAFLD and atherosclerosis, and to identify possible mechanisms linking them.
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, China.|Digestive Disease Key Laboratory of Qingdao, Qingdao, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.affiliation: Digestive Disease Key Laboratory of Qingdao, Qingdao, China.|Central Laboratories, Qingdao Municipal Hospital, Qingdao, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, China.|Digestive Disease Key Laboratory of Qingdao, Qingdao, China.
authors.forename: Quanyong
authors.initials: Q
authors.lastname: Dong
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, China.|Digestive Disease Key Laboratory of Qingdao, Qingdao, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, China.|Digestive Disease Key Laboratory of Qingdao, Qingdao, China.
authors.forename: Nannan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, China. xinyongning@163.com.|Digestive Disease Key Laboratory of Qingdao, Qingdao, China. xinyongning@163.com.|Central Laboratories, Qingdao Municipal Hospital, Qingdao, China. xinyongning@163.com.
authors.forename: Yongning
authors.initials: Y
authors.lastname: Xin
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, China. xuansydxy@163.com.|Digestive Disease Key Laboratory of Qingdao, Qingdao, China. xuansydxy@163.com.|Central Laboratories, Qingdao Municipal Hospital, Qingdao, China. xuansydxy@163.com.
authors.forename: Shiying
authors.initials: S
authors.lastname: Xuan
mesh_terms: D054392:Adipokines / Q000502:physiology; D000818:Animals; D050197:Atherosclerosis / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000276:immunology / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D018384:Oxidative Stress; D012307:Risk Factors
chemical_list: D054392:Adipokines