title: Pathological brain detection in MRI scanning by wavelet packet Tsallis entropy and fuzzy support vector machine.
abstract: An computer-aided diagnosis system of pathological brain detection (PBD) is important for help physicians interpret and analyze medical images. We proposed a novel automatic PBD to distinguish pathological brains from healthy brains in magnetic resonance imaging scanning in this paper. The proposed method simplified the PBD problem to a binary classification task. We extracted the wavelet packet Tsallis entropy (WPTE) from each brain image. The WPTE is the Tsallis entropy of the coefficients of the discrete wavelet packet transform. The, the features were submitted to the fuzzy support vector machine (FSVM). We tested the proposed diagnosis method on 3 benchmark datasets with different sizes. A ten runs of K-fold stratified cross validation was carried out. The results demonstrated that the proposed WPTE + FSVM method excelled 17 state-of-the-art methods w.r.t. classification accuracy. The WPTE is superior to discrete wavelet transform. The Tsallis entropy performs better than Shannon entropy. The FSVM excels standard SVM. In closing, the proposed method "WPTE + FSVM" is effective in PBD.
authors.affiliation: School of Computer Science and Technology, Nanjing Normal University, Nanjing, Jiangsu 210023 China.|Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing, Jiangsu 210042 China.
authors.forename: Yu-Dong
authors.initials: YD
authors.lastname: Zhang
authors.affiliation: School of Computer Science and Technology, Nanjing Normal University, Nanjing, Jiangsu 210023 China.|Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing, Jiangsu 210042 China.
authors.forename: Shui-Hua
authors.initials: SH
authors.lastname: Wang
authors.affiliation: Department of Mathematics and Mechanics, China University of Mining and Technology, Xuzhou, Jiangsu 221008 China.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Yang
authors.affiliation: Translational Imaging Division and MRI Unit, Columbia University and New York State Psychiatric Institute, New York, NY 10032 USA.
authors.forename: Zheng-Chao
authors.initials: ZC
authors.lastname: Dong
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032 USA.
authors.forename: Ge
authors.initials: G
authors.lastname: Liu
authors.affiliation: School of Natural Sciences and Mathematics, Shepherd University, Shepherdstown, WV 25443 USA.
authors.forename: Preetha
authors.initials: P
authors.lastname: Phillips
authors.affiliation: School of Psychology, Nanjing Normal University, Nanjing, Jiangsu 210008 China.
authors.forename: Ti-Fei
authors.initials: TF
authors.lastname: Yuan
keywords: Computer-aided diagnosis; Discrete wavelet packet transform; Fuzzy support vector machine; Magnetic resonance imaging; Pathological brain detection (PBD); Pattern recognition; Tsallis entropy