title: [Association of lymphoma and granulomatosis: A case series].
abstract: OBJECTIVE
  The sarcoidosis-lymphoma syndrome is a recognised entity. However, the presence of granulomas in patients with a haematological disease should not lead too easily to a diagnosis of sarcoidosis. The presence of granulomatous lesions during the follow-up of these patients raises diagnostic and therapeutic issues.
  
  
  METHODS
  We included 25 patients followed by the department of haematology in a French hospital (Centre Léon-Bérard). These patients presented with granulomatous lesions. Patients with a history of sarcoidosis were excluded. We report the type of haematological disease, the time of onset of the granulomatous disease compared to that of lymphoma, associated symptoms, aetiology and outcome. Patients were divided into three groups according to the time of onset of the granulomatous lesions.
  
  
  RESULTS
  Granulomatous lesions appeared before the haematological disease in 4 cases, was concomitant in 8 cases and appeared later in 13 remaining cases. The two main subtypes of lymphoma encountered were: diffuse large cell lymphoma (36%) and Hodgkin's lymphoma (28%). Granulomatous lesions were related to the progression of the hematological disease in 11 cases, to sarcoidosis in 4 cases, to infection in 3 cases, to drug allergy in one case, to inflammatory bowel disease in one case, to granuloma annulare in one case and was isolated in 4 cases (no identified etiology). In the group where granulomas appeared after the haematological disease, mean SUV was 11 for the haematological disease versus 6.4 for granulomas.
  
  
  CONCLUSIONS
  Granulomatous diseases in lymphomas can be due to various aetiologies: infection, reaction to the haematological disease, or systemic sarcoidosis. It is an important challenge for clinicians, who can miss the diagnosis of lymphoma and or conclude to a treatment failure or a relapse. Computed tomography scan (CT-scan) or (18)F-deoxyglucose-positron emission tomography scan can help establish a diagnosis but do not replace biopsy.
authors.affiliation: Service de médecine interne, hôpital Édouard-Herriot, 5, place d'Arsonval, 69003 Lyon, France; Service d'hématologie, centre Léon-Bérard, 28, rue Laënnec, 69003 Lyon, France; Service de médecine interne, hôpital d'Instruction des Armées Desgenettes, 108, boulevard Pinel, 69003 Lyon, France. Electronic address: f.decharry@gmail.com.
authors.forename: F
authors.initials: F
authors.lastname: de Charry
authors.affiliation: Service de médecine nucléaire, centre Léon-Bérard, 28, rue Laënnec, 69003 Lyon, France.
authors.forename: K
authors.initials: K
authors.lastname: Sadoune
authors.affiliation: Service d'hématologie, centre Léon-Bérard, 28, rue Laënnec, 69003 Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Sebban
authors.affiliation: Service d'hématologie, centre Léon-Bérard, 28, rue Laënnec, 69003 Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Rey
authors.affiliation: Service d'hématologie, centre Léon-Bérard, 28, rue Laënnec, 69003 Lyon, France.
authors.forename: A
authors.initials: A
authors.lastname: de Parisot
authors.affiliation: Service d'hématologie, centre Léon-Bérard, 28, rue Laënnec, 69003 Lyon, France.
authors.forename: E
authors.initials: E
authors.lastname: Nicolas-Virelizier
authors.affiliation: Service d'hématologie, centre Léon-Bérard, 28, rue Laënnec, 69003 Lyon, France.
authors.forename: A
authors.initials: A
authors.lastname: Belhabri
authors.affiliation: Service d'hématologie, centre Léon-Bérard, 28, rue Laënnec, 69003 Lyon, France.
authors.forename: H
authors.initials: H
authors.lastname: Ghesquières
authors.affiliation: Service de médecine interne, hôpital Édouard-Herriot, 5, place d'Arsonval, 69003 Lyon, France.
authors.forename: J
authors.initials: J
authors.lastname: Ninet
authors.affiliation: Service de médecine interne, hôpital Édouard-Herriot, 5, place d'Arsonval, 69003 Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Faurie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18; D005602:France; D006099:Granuloma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: (18)FDG-PET-scanner; Granulomatose; Granulomatosis; Haematological malignancy; Hémopathie; TEP-scanner; Tuberculose; Tuberculosis