title: Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop.
abstract: Both biomedical research and clinical practice rely on complex datasets for the physiological and genetic characterization of human hearts in health and disease. Given the complexity and variety of approaches and recordings, there is now growing recognition of the need to embed computational methods in cardiovascular medicine and science for analysis, integration and prediction. This paper describes a Workshop on Computational Cardiovascular Science that created an international, interdisciplinary and inter-sectorial forum to define the next steps for a human-based approach to disease supported by computational methodologies. The main ideas highlighted were (i) a shift towards human-based methodologies, spurred by advances in new in silico, in vivo, in vitro, and ex vivo techniques and the increasing acknowledgement of the limitations of animal models. (ii) Computational approaches complement, expand, bridge, and integrate in vitro, in vivo, and ex vivo experimental and clinical data and methods, and as such they are an integral part of human-based methodologies in pharmacology and medicine. (iii) The effective implementation of multi- and interdisciplinary approaches, teams, and training combining and integrating computational methods with experimental and clinical approaches across academia, industry, and healthcare settings is a priority. (iv) The human-based cross-disciplinary approach requires experts in specific methodologies and domains, who also have the capacity to communicate and collaborate across disciplines and cross-sector environments. (v) This new translational domain for human-based cardiology and pharmacology requires new partnerships supported financially and institutionally across sectors. Institutional, organizational, and social barriers must be identified, understood and overcome in each specific setting.
authors.affiliation: Department of Computer Science, University of Oxford, Oxford, UK blanca.rodriguez@cs.ox.ac.uk.
authors.forename: Blanca
authors.initials: B
authors.lastname: Rodriguez
authors.affiliation: Medical Humanities, University of Sheffield, Sheffield, UK.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Carusi
authors.affiliation: AnaBios Corporation, San Diego Science Center, San Diego, CA 92109, USA.
authors.forename: Najah
authors.initials: N
authors.lastname: Abi-Gerges
authors.affiliation: Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
authors.forename: Rina
authors.initials: R
authors.lastname: Ariga
authors.affiliation: Department of Computer Science, University of Oxford, Oxford, UK.
authors.forename: Oliver
authors.initials: O
authors.lastname: Britton
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
authors.forename: Gil
authors.initials: G
authors.lastname: Bub
authors.affiliation: Department of Computer Science, University of Oxford, Oxford, UK.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Bueno-Orovio
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
authors.forename: Rebecca A B
authors.initials: RA
authors.lastname: Burton
authors.affiliation: Department of Engineering Science, University of Oxford, Oxford, UK.
authors.forename: Valentina
authors.initials: V
authors.lastname: Carapella
authors.affiliation: Department of Computer Science, University of Oxford, Oxford, UK.
authors.forename: Louie
authors.initials: L
authors.lastname: Cardone-Noott
authors.affiliation: Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Daniels
authors.affiliation: QT-Informatics Limited, Macclesfield, UK.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Davies
authors.affiliation: Department of Computer Science, University of Oxford, Oxford, UK.
authors.forename: Sara
authors.initials: S
authors.lastname: Dutta
authors.affiliation: AnaBios Corporation, San Diego Science Center, San Diego, CA 92109, USA.
authors.forename: Andre
authors.initials: A
authors.lastname: Ghetti
authors.affiliation: Department of Engineering Science, University of Oxford, Oxford, UK.
authors.forename: Vicente
authors.initials: V
authors.lastname: Grau
authors.affiliation: William Harvey Heart Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: Harmer
authors.affiliation: Discovery Sciences, Dis&Dev Research, Janssen Pharmaceutical NV, Beerse, Belgium.
authors.forename: Ivan
authors.initials: I
authors.lastname: Kopljar
authors.affiliation: Institute of Cardiovascular Science, University College London, Bars Heart Centre, London, UK.
authors.forename: Pier
authors.initials: P
authors.lastname: Lambiase
authors.affiliation: Discovery Sciences, Dis&Dev Research, Janssen Pharmaceutical NV, Beerse, Belgium.
authors.forename: Hua Rong
authors.initials: HR
authors.lastname: Lu
authors.affiliation: Department of Computer Science, University of Oxford, Oxford, UK.
authors.forename: Aurore
authors.initials: A
authors.lastname: Lyon
authors.affiliation: Department of Computer Science, University of Oxford, Oxford, UK.
authors.forename: Ana
authors.initials: A
authors.lastname: Minchole
authors.affiliation: Department of Computer Science, University of Oxford, Oxford, UK.
authors.forename: Anna
authors.initials: A
authors.lastname: Muszkiewicz
authors.affiliation: Department of Engineering Science, University of Oxford, Oxford, UK.
authors.forename: Julien
authors.initials: J
authors.lastname: Oster
authors.affiliation: Department of Electronics and Communications Engineering, Tampere University of Technology, BioMediTech, Tampere, Finland.
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Paci
authors.affiliation: Department of Computer Science, University of Oxford, Oxford, UK.
authors.forename: Elisa
authors.initials: E
authors.lastname: Passini
authors.affiliation: Department of Electrical, Electronic and Information Engineering, University of Bologna, Cesena 47521, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Severi
authors.affiliation: Institute of Cardiovascular Science, University College London, Bars Heart Centre, London, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Taggart
authors.affiliation: William Harvey Heart Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.
authors.forename: Andy
authors.initials: A
authors.lastname: Tinker
authors.affiliation: Non-Clinical Development, UCB-Biopharma, Braine L'Alleud B-1420, Belgium.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Valentin
authors.affiliation: University of Szeged, Szeged, Hungary.
authors.forename: Andras
authors.initials: A
authors.lastname: Varro
authors.affiliation: Fraunhofer-Chambers Centre, Gothenburg, Sweden.
authors.forename: Mikael
authors.initials: M
authors.lastname: Wallman
authors.affiliation: Department of Computer Science, University of Oxford, Oxford, UK.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D057791:Cardiac Imaging Techniques; D002309:Cardiology / Q000379:methods*; D066126:Cardiotoxicity; D002317:Cardiovascular Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003299:Cooperative Behavior; D004059:Diffusion of Innovation; D022062:Electrophysiologic Techniques, Cardiac; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D033183:Interdisciplinary Communication; D008955:Models, Cardiovascular; D066230:Patient-Specific Modeling; D010600:Pharmacology / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D055818:Public-Private Sector Partnerships; D057170:Translational Research, Biomedical / Q000379:methods*
chemical_list: D015415:Biomarkers; D002317:Cardiovascular Agents
keywords: Arrhythmias; Biomarkers; Computational approaches; Computer modelling and simulations; Human electrophysiology; Human-based methods; Stem-cell-derived cardiomyocytes