title: Mosquito Defense Strategies against Viral Infection.
abstract: Mosquito-borne viral diseases are a major concern of global health and result in significant economic losses in many countries. As natural vectors, mosquitoes are very permissive to and allow systemic and persistent arbovirus infection. Intriguingly, persistent viral propagation in mosquito tissues neither results in dramatic pathological sequelae nor impairs the vectorial behavior or lifespan, indicating that mosquitoes have evolved mechanisms to tolerate persistent infection and developed efficient antiviral strategies to restrict viral replication to nonpathogenic levels. Here we provide an overview of recent progress in understanding mosquito antiviral immunity and advances in the strategies by which mosquitoes control viral infection in specific tissues.
authors.affiliation: Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Tsinghua University, Beijing 100084, PR China. Electronic address: gongcheng@mail.tsinghua.edu.cn.
authors.forename: Gong
authors.initials: G
authors.lastname: Cheng
authors.affiliation: Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Tsinghua University, Beijing 100084, PR China; School of Life Science, Tsinghua University, Beijing 100084, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Microbiology and Immunology, School of Medicine, New York Medical College, Valhalla, NY 10595, USA.
authors.forename: Penghua
authors.initials: P
authors.lastname: Wang
authors.affiliation: Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Tsinghua University, Beijing 100084, PR China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Xiao
mesh_terms: D000818:Animals; D001103:Arboviruses / Q000502:physiology*; D009033:Culicidae / Q000235:genetics / Q000276:immunology / Q000821:virology*; D006458:Hemolymph / Q000276:immunology; D009474:Neurons / Q000276:immunology / Q000821:virology; D034622:RNA Interference; D012469:Salivary Glands / Q000276:immunology / Q000821:virology; D014779:Virus Replication
keywords: antiviral immunity; arbovirus; mosquito