title: MicroRNAs in Testicular Cancer Diagnosis and Prognosis.
abstract: Testicular cancer processes a unique and clear miRNA expression signature. This differentiates testicular cancer from most other cancer types, which are usually more ambiguous when assigning miRNA patterns. As such, testicular cancer may represent a unique cancer type in which miRNAs find their use as biomarkers for cancer diagnosis and prognosis, with a potential to surpass the current available markers usually with low sensitivity. In this review, we present literature findings on miRNAs associated with testicular cancer, and discuss their potential diagnostic and prognostic values, as well as their potential as indicators of drug response in patients with testicular cancer.
authors.affiliation: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77054, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Ling
authors.affiliation: Division of Oncology, Department of Internal Medicine, Medical University of Graz (MUG), Graz, Austria.
authors.forename: Lisa
authors.initials: L
authors.lastname: Krassnig
authors.affiliation: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77054, USA.
authors.forename: Marc D
authors.initials: MD
authors.lastname: Bullock
authors.affiliation: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77054, USA; Division of Oncology, Department of Internal Medicine, Medical University of Graz (MUG), Graz, Austria. Electronic address: mart.pichler@gmx.net.
authors.forename: Martin
authors.initials: M
authors.lastname: Pichler
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000032:analysis*; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D011379:Prognosis; D012680:Sensitivity and Specificity; D013736:Testicular Neoplasms / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: Biomarkers; Detection; MicroRNA; Prognosis; Testicular cancer