title: Study of Common Illnesses Before and After Vaccination: A Risk interval Approach.
abstract: OBJECTIVE
  To compare the proportion of children who developed a specified illness in the 7 day post-vaccination window, with the background rate of the same event in the 7 day pre-vaccination window.
  
  
  METHODS
  Risk interval approach (Self-controlled case-series).
  
  
  METHODS
  Well Baby Clinic of Christian Medical College, Vellore.
  
  
  METHODS
  1602 healthy infants and under-six children presenting for routine vaccination.
  
  
  METHODS
  Episode of any illness.
  
  
  METHODS
  The interviewer enquired about any adverse event or illness experienced by the child for each day of the week preceding the administration of age-appropriate vaccines. A second interview (telephonic) was conducted by the same interviewer one week following vaccine administration to enquire about adverse event(s) experienced by the child for each day of the subsequent week using a similar protocol.
  
  
  RESULTS
  With multiple vaccines delivered at appropriate ages, common childhood illnesses that could be reported as adverse events following immunization, except fever (RR=5.7, 95% CI=4.50-7.35), occurred at higher rates pre-vaccination. Risk Ratios of fever following whole cell (RR=9.3, 95% CI=6.43-13.52) and acellular (RR=8.5, 95% CI=3.82-18.91) vaccines were similar, with both showing a decreasing trend with increasing age. The gastrointestinal adverse event profile [diarrhea (RR=0.6, 95% CI=0.14-2.51) and vomiting (RR=1.0, 95% CI=0.14-7.10)] for rotavirus vaccine was similar pre- and post-immunization.
  
  
  CONCLUSIONS
  Since most adverse events to vaccines are also common childhood illnesses, estimating the background rates of common illnesses is important to accurately ascertain a causal relationship.
authors.affiliation: Departments of Child Health and *Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India. Correspondence to: Dr Rajeev Z Kompithra, Department of Child Health, Christian Medical College and Hospital, Vellore, Tamil Nadu, India. rajeev.k_zachariah@yahoo.in.
authors.forename: Rajeev Z
authors.initials: RZ
authors.lastname: Kompithra
authors.forename: Rajiv
authors.initials: R
authors.lastname: Sarkar
authors.forename: Leni G
authors.initials: LG
authors.lastname: Mathew
authors.forename: Jayaprakash
authors.initials: J
authors.lastname: Muliyil
authors.forename: Gagandeep
authors.initials: G
authors.lastname: Kang
mesh_terms: D002675:Child, Preschool; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D018570:Risk Assessment; D014611:Vaccination / Q000009:adverse effects* / Q000706:statistics & numerical data*; D014612:Vaccines / Q000009:adverse effects*
chemical_list: D014612:Vaccines