title: An Efficient and Facile Method for the Synthesis of Benzimidazoisoquinoline Derivatives via a Multicomponent Reaction.
abstract: Two series of benzimidazoisoquinoline and fused benzimidazoisoquinoline-benzimidazole derivatives have been synthesized using an efficient one-pot procedure. This process involves an intramolecular nucleophilic substitution reaction and provides facile access to two series of complexes and potentially interesting biologically active scaffolds.
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Liao
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.
authors.forename: Shi-Qiang
authors.initials: SQ
authors.lastname: Li
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.
authors.forename: Zhi-Yu
authors.initials: ZY
authors.lastname: Zhang
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Yang
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.
authors.forename: Di
authors.initials: D
authors.lastname: Xu
authors.affiliation: Key Laboratory of Tumor Immunopathology, Ministry of Education of China , Chongqing 400038, China.|Department of Oncology, Chengdu Military General Hospital , Chengdu, Sichuan 610083, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Xu
authors.affiliation: Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital , Sichuan 610072, China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Lan
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.
authors.forename: Zhong-Zhu
authors.initials: ZZ
authors.lastname: Chen
authors.affiliation: International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences , 319 Honghe Avenue, Yongchuan, Chongqing 402160, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Xu
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D054879:Halogenation; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001562:Benzimidazoles; D007546:Isoquinolines; D054852:Small Molecule Libraries
keywords: benzimidazoisoquinoline; benzimidazole; multicomponent reactions (MCRs); nucleophilic substitution reaction; one-pot