title: The risk for end-stage renal disease is increased after burn.
abstract: OBJECTIVE
  Acute kidney injury (AKI) commonly complicates burn. Recently, AKI has been suggested to be causally related to chronic end-stage renal disease (ESRD), but controversial data also exist. Our aim was to study the risk of ESRD after burn in a nationwide analysis.
  
  
  METHODS
  All burn patients undergoing hospitalization between 1998 and 2011 were identified from the National Hospital Discharge Register, and the data were linked with the Finnish Registry for Kidney Diseases, which includes all individuals receiving chronic renal replacement therapy (RRT) in Finland.
  
  
  RESULTS
  Altogether 41,179 adults were treated at hospitals for burns in Finland between 1998 and 2011. Of these, 86 had a diagnosis of AKI related to the burn. Forty-three burn survivors had ESRD and RRT initiated related to or after the burn. The overall risk for ESRD after burn was increased (standardized incidence ratio, SIR, 2.40, 95% CI 1.73-3.23) compared with the Finnish population. Standardized incidence ratio was 3.11 (95% CI 1.66-5.32) in women and 1.89 (95% CI 1.27-2.69) in men. Of these 43 patients, 38 had a specific non-burn-related diagnosis of ESRD identified in the registry, and ESRD was deemed unlikely to be directly related to the burn. In five patients, the diagnosis of ESRD was unknown cause of renal failure, and causality of the burn with ESRD was evaluated as plausible.
  
  
  CONCLUSIONS
  In conclusion, a significantly increased risk of ESRD was recorded after a severe burn. Our results do not support increased incidence of ESRD solely as a consequence of AKI due to burn, but burn may increase the risk of ESRD in patients with pre-existing chronic kidney disease.
authors.affiliation: Department of Transplant and Liver Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: Ilkka
authors.initials: I
authors.lastname: Helanterä
authors.affiliation: Department of Plastic Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address: virve.koljonen@hus.fi.
authors.forename: Virve
authors.initials: V
authors.lastname: Koljonen
authors.affiliation: Department of Medicine, Division of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Finnish Registry for Kidney Diseases, Helsinki, Finland.
authors.forename: Patrik
authors.initials: P
authors.lastname: Finne
authors.affiliation: Department of Plastic Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: Erkki
authors.initials: E
authors.lastname: Tukiainen
authors.affiliation: National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: Mika
authors.initials: M
authors.lastname: Gissler
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002056:Burns / Q000453:epidemiology*; D002648:Child; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012042:Registries; D017582:Renal Replacement Therapy; D012307:Risk Factors; D012737:Sex Factors; D017741:Survivors; D055815:Young Adult
keywords: Acute kidney injury; Complication; End-stage renal disease