title: [Effect of Dermal Multipotent Cells Transplantation on Skin Elasticity in Aged Murine].
abstract: OBJECTIVE
  To investigate the elasticity changes in aged dermis after injection of dermal multipotent cells (DMCs).
  
  
  METHODS
  Dermal multipotent cells were isolated and cultured from 3-day-old BALB/c mice and then transplanted into the dermis of aged (12-week-old) BALB/c mice. Adult fibroblasts (FBs) were employed as control. At 2 and 4 weeks after the transplantation, we examined dermal elasticity by MPA580 skin test machine.
  
  
  RESULTS
  The skin elasticity were improve at 2 weeks after the transplantion in both DMCs group and FBs group (P=0. 000) but have no statistical difference between these two groups (P=0. 216). The different effect between these two groups appeared in 4 weeks after the transplantation (P=0. 031).
  
  
  CONCLUSIONS
  Dermal multipotent cells appear more effective than fibroblasts in increasing skin elasticity.
authors.forename: Si-liang
authors.initials: SL
authors.lastname: Xue
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Shan-shan
authors.initials: SS
authors.lastname: Huang
authors.forename: Cheng-xia
authors.initials: CX
authors.lastname: Zhou
mesh_terms: D000818:Animals; D020405:Dermis; D004548:Elasticity; D005347:Fibroblasts / Q000166:cytology; D051379:Mice; D008807:Mice, Inbred BALB C; D039902:Multipotent Stem Cells / Q000166:cytology / Q000637:transplantation*; D015595:Skin Aging