title: Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis.
abstract: Over the past two decades, the domains of both frontline synthetic organic chemistry and process chemistry and have seen an increase in crosstalk between asymmetric organic/organometallic approaches and enzymatic approaches to stereocontrolled synthesis. This review highlights the particularly auspicious role for dehydrogenase enzymes in this endeavor, with a focus on dynamic reductive kinetic resolutions (DYRKR) to "deracemize" building blocks, often setting two stereocenters in so doing. The scope and limitations of such dehydrogenase-mediated processes are overviewed, as are future possibilities for the evolution of enzymatic DYRKR.
authors.affiliation: Department of Chemistry, University of Nebraska, Lincoln, NE 68588-0304 USA.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Applegate
authors.affiliation: Department of Chemistry, University of Nebraska, Lincoln, NE 68588-0304 USA.
authors.forename: David B
authors.initials: DB
authors.lastname: Berkowitz
keywords: Asymmetric synthesis; biocatalysis; dehydrogenase enzymes; deracemization; dynamic kinetic resolution