title: Circulating fibroblast growth factor 23 in children on peritoneal dialysis is associated with effective dialysis.
abstract: Our purpose was to assess the relationship between serum fibroblast growth factor 23 (FGF23) and left ventricular function, carotid intima-media thickness (CIMT) and laboratory features in children on peritoneal dialysis (PD). The study population consisted of 17 patients (11 female; median age 7.83 years, range 0.66-17.75) undergoing PD for 22 months (range 2-98). Serum FGF23, serum phosphorus, calcium, intact parathyroid hormone (iPTH), 25(OH) vitamin D, 1,25(OH)2 vitamin D and Kt/V urea, left ventricular mass (LVM) and LVM index (LVMI) were assessed. Median FGF23 level was 29.92 pg/ml (22.7-74.76), phosphorus was 5.2 mg/dl (3.1-9.9), iPTH was 438 pg/ml (16-1446), 25(OH) vitamin D was 11 ng/ml (5-35), 1,25(OH)2 vitamin D was 11 pg/ml (2-106), Kt/V urea was 2.33 (1.01-3.84). FGF23 level was independently associated with Kt/V urea (p<0.001). We found that effective dialysis may be the leading determinant of FGF level, independent from the calcium-phosphorus-PTH axis, in pediatric PD patients.
authors.affiliation: Divisions of Pediatric Nephrology, Department of Pediatrics,Hacettepe University Faculty of Medicine, Ankara, Turkey. dhacihamdioglu@gata.edu.tr.
authors.forename: Duygu Övünç
authors.initials: DÖ
authors.lastname: Hacıhamdioğlu
authors.forename: Ali
authors.initials: A
authors.lastname: Düzova
authors.forename: Dursun
authors.initials: D
authors.lastname: Alehan
authors.forename: Berna
authors.initials: B
authors.lastname: Oğuz
authors.forename: Nesrin
authors.initials: N
authors.lastname: Beşbaş
mesh_terms: D000293:Adolescent; D002118:Calcium / Q000097:blood; D059168:Carotid Intima-Media Thickness; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology; D007223:Infant; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010530:Peritoneal Dialysis / Q000009:adverse effects / Q000379:methods*; D010758:Phosphorus / Q000097:blood; D016277:Ventricular Function, Left / Q000502:physiology; D014807:Vitamin D / Q000097:blood
chemical_list: C000717427:FGF23 protein, human; D010281:Parathyroid Hormone; D014807:Vitamin D; D010758:Phosphorus; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002118:Calcium