title: Evaluation of galectin-3 levels in acute coronary syndrome.
abstract: Galectin-3 is a new biomarker that is assumed to reflect fibrogenesis and inflammation. In this study, we aimed to evaluate the levels of galectin-3 in patients with acute coronary syndrome (ACS) and the relation of galectin-3 to the burden of atherosclerosis. Nineteen patients with ACS who underwent coronary angiography and 17 age-matched healthy controls were enrolled. The burden of atherosclerosis was assessed with Gensini score and with the number of involved vessels. Galectin-3 levels were measured on admission by using ELISA. The mean age of the cohort was 62.8±10.6 and 56% of the patients were male. Compared to control group, median galectin-3 levels were significantly higher in ACS patients (0.77ng/mL [0.50-1.19] vs. 0.51ng/mL [0.41-0.78], P=0.01). Patients were classified into three groups according to the number of involved vessels. Median galectin-3 levels did not differ significantly among groups (one vessel: 0.68ng/mL [0.55-0.74], two vessels: 0.67ng/mL [0.46-1.84], three vessels 0.90ng/mL [0.53-1.38], P=0.62). There was a strong correlation between galectin-3 levels and Gensini score (r=0.625, P=0.004). In conclusion, galectin-3 levels were elevated in patients with ACS and there was a strong correlation between galectin-3 levels and Gensini score.
authors.affiliation: Department of Cardiology, Polatli Hospital, Ankara, Turkey. Electronic address: esragucuk@hotmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Gucuk Ipek
authors.affiliation: Faculty of Sports Sciences, Hacettepe University, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Akin Suljevic
authors.affiliation: Department of Cardiology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Kafes
authors.affiliation: Department of Cardiology, Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Basyigit
authors.affiliation: Department of Biochemistry, Polatli Hospital, Ankara, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Karalok
authors.affiliation: Department of Cardiology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Guray
authors.affiliation: Department of Cardiology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: L
authors.initials: L
authors.lastname: Dinc Asarcikli
authors.affiliation: Department of Cardiology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Acar
authors.affiliation: Faculty of Sports Sciences, Hacettepe University, Ankara, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Demirel
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging; D050197:Atherosclerosis / Q000000981:diagnostic imaging; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D017023:Coronary Angiography; D005260:Female; D037502:Galectin 3 / Q000097:blood*; D005919:Glomerular Filtration Rate; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013318:Stroke Volume
chemical_list: D015415:Biomarkers; D037502:Galectin 3
keywords: Acute coronary syndrome; Atherosclerosis; Athérosclérose; Biomarker; Biomarqueur; Galectin-3; Galectine-3; Gensini; Syndrome coronarien aigu