title: Bioluminescence Probe for Detecting Hydrogen Sulfide in Vivo.
abstract: Considering that hydrogen sulfide (H2S) is an endogenous signaling molecule involved in numerous biological processes, a method for monitoring H2S as a powerful tool for investigating its complicated functions and mechanisms is urgently demanded. Herein, a bioluminescent turn-on probe was reported based on caged strategy for the detection of H2S in vitro and in vivo. This probe will help us understand the intricate contribution of H2S to a variety of physiological and pathological processes.
authors.affiliation: Laboratory of Anaesthesiology & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University , Chengdu, Sichuan 610041, China.
authors.forename: Bowen
authors.initials: B
authors.lastname: Ke
authors.affiliation: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University , Jinan, Shandong 250012, China.
authors.forename: Wenxiao
authors.initials: W
authors.lastname: Wu
authors.affiliation: Laboratory of Anaesthesiology & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University , Chengdu, Sichuan 610041, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Laboratory of Anaesthesiology & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University , Chengdu, Sichuan 610041, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liang
authors.affiliation: Laboratory of Anaesthesiology & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University , Chengdu, Sichuan 610041, China.
authors.forename: Deying
authors.initials: D
authors.lastname: Gong
authors.affiliation: Laboratory of Anaesthesiology & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University , Chengdu, Sichuan 610041, China.
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University , Jinan, Shandong 250012, China.
authors.forename: Minyong
authors.initials: M
authors.lastname: Li
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006862:Hydrogen Sulfide / Q000032:analysis* / Q000737:chemistry; D049408:Luminescent Agents / Q000032:analysis / Q000737:chemistry*; D008163:Luminescent Measurements / Q000379:methods*; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D049408:Luminescent Agents; D006862:Hydrogen Sulfide