title: Polymeric behavior evaluation of PVP K30-poloxamer binary carrier for solid dispersed nisoldipine by experimental design.
abstract: BACKGROUND
  High melting point polymeric carrier without plasticizer is unacceptable for solid dispersion (SD) by melting method. Combined polymer-plasticizer carrier significantly affects drug solubility and tableting property of SD.
  
  
  OBJECTIVE
  To evaluate and optimize the combined effect of a binary carrier consisting PVP K30 and poloxamer 188, on nisoldipine solubility and tensile strength of amorphous SD compact (SDcompact) by experimental design.
  
  
  METHODS
  SD of nisoldpine (SDnisol) was prepared by melt mixing with different PVP K30 and poloxamer amount. A 32factorial design was employed using nisoldipine solubility and tensile strength of SDcompactas response variables. Statistical optimization by design expert software, and SDnisolcharacterization using ATR FTIR, DSC and microscopy were done.
  
  
  RESULTS
  PVP K30:poloxamer, at a ratio of 3.73:6.63, was selected as the optimized combination of binary polymeric carrier resulting nisoldipine solubility of 115 μg/mL and tensile strength of 1.19 N/m2.
  
  
  CONCLUSIONS
  PVP K30 had significant positive effect on both responses. Increase in poloxamer concentration after a certain level decreased nisoldipine solubility and tensile strength of SDcompact.
  
  
  CONCLUSIONS
  An optimized PVP K30-poloxamer binary composition for SD carrier was developed. Tensile strength of SDcompactcan be considered as a response for experimental design to optimize SD.
authors.affiliation: a Department of Pharmaceutical Technology , Kulliyyah of Pharmacy, International Islamic University Malaysia , Kuantan , Malaysia.
authors.forename: May
authors.initials: M
authors.lastname: Kyaw Oo
authors.affiliation: a Department of Pharmaceutical Technology , Kulliyyah of Pharmacy, International Islamic University Malaysia , Kuantan , Malaysia.
authors.forename: Uttam K
authors.initials: UK
authors.lastname: Mandal
authors.affiliation: a Department of Pharmaceutical Technology , Kulliyyah of Pharmacy, International Islamic University Malaysia , Kuantan , Malaysia.
authors.forename: Bappaditya
authors.initials: B
authors.lastname: Chatterjee
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry; D015737:Nisoldipine / Q000008:administration & dosage* / Q000737:chemistry; D010968:Plasticizers / Q000737:chemistry; D020442:Poloxamer / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets; D013718:Tensile Strength
chemical_list: D000959:Antihypertensive Agents; D004337:Drug Carriers; D005079:Excipients; D010968:Plasticizers; D013607:Tablets; D020442:Poloxamer; D015737:Nisoldipine; D011205:Povidone
keywords: Factorial design; nisoldipine; solid dispersion; solubility