title: Hepatitis B virus infection and genotype in asymptomatic people from 10 ethnic groups in Yunnan, China.
abstract: OBJECTIVE
  To evaluate the infection and genotype distribution of hepatitis B virus (HBV) in ethnic groups in Yunnan, China.
  
  
  METHODS
  Two thousand five hundred and eighty-four asymptomatic local people from 10 ethnic groups were investigated in Yunnan, China. Infection and genotype distribution were evaluated by serological and genetic methods. Genotyping was verified by sequencing. Ethnic genotype distribution was compared by proportion test.
  
  
  RESULTS
  Four types of infection model based on HBV serum markers were identified, and the average HBV infection rate was 5.7% in those asymptomatic local people. The genotype prevalence was 59.6% for B, 21.1% for C and 19.3% BC; subgenotypes Ba, Cs and Ce were identified in this study. Hepatitis B surface antigen-positive rate and the proportion of genotype B were significantly lower in ethnic groups with a northern origin compared to those with a southern origin (50% vs 73.9%, P = 0.037; 4.2% vs 10.5%, P = 0.000).
  
  
  CONCLUSIONS
  Genotype B is dominant and genotype BC has high occurrence in asymptomatic local ethnic groups in Yunnan. HBV infection status and genotype distribution may associate with ethnic origin.
authors.affiliation: Yuan-Ying Shen, Wei Hou, Zhan-Qiu Yang, Institute of Virology, Medical School of Wuhan University, Wuhan 430071, Hubei Province, China.
authors.forename: Yuan-Ying
authors.initials: YY
authors.lastname: Shen
authors.affiliation: Yuan-Ying Shen, Wei Hou, Zhan-Qiu Yang, Institute of Virology, Medical School of Wuhan University, Wuhan 430071, Hubei Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Hou
authors.affiliation: Yuan-Ying Shen, Wei Hou, Zhan-Qiu Yang, Institute of Virology, Medical School of Wuhan University, Wuhan 430071, Hubei Province, China.
authors.forename: Zhan-Qiu
authors.initials: ZQ
authors.lastname: Yang
authors.affiliation: Yuan-Ying Shen, Wei Hou, Zhan-Qiu Yang, Institute of Virology, Medical School of Wuhan University, Wuhan 430071, Hubei Province, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Xiao
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000097:blood / Q000175:diagnosis / Q000208:ethnology*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D010641:Phenotype; D055815:Young Adult
chemical_list: D015415:Biomarkers; D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens
keywords: BC genotype; China; Ethnic distribution; Hepatitis B virus; Infection and genotype; Yunnan