title: Acute Respiratory Distress Syndrome: Role of Oleic Acid-Triggered Lung Injury and Inflammation.
abstract: Lung injury especially acute respiratory distress syndrome (ARDS) can be triggered by diverse stimuli, including fatty acids and microbes. ARDS affects thousands of people worldwide each year, presenting high mortality rate and having an economic impact. One of the hallmarks of lung injury is edema formation with alveoli flooding. Animal models are used to study lung injury. Oleic acid-induced lung injury is a widely used model resembling the human disease. The oleic acid has been linked to metabolic and inflammatory diseases; here we focus on lung injury. Firstly, we briefly discuss ARDS and secondly we address the mechanisms by which oleic acid triggers lung injury and inflammation.
authors.affiliation: Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (FIOCRUZ), 21040-900 Rio de Janeiro, RJ, Brazil.
authors.forename: Cassiano Felippe
authors.initials: CF
authors.lastname: Gonçalves-de-Albuquerque
authors.affiliation: Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (FIOCRUZ), 21040-900 Rio de Janeiro, RJ, Brazil.
authors.forename: Adriana Ribeiro
authors.initials: AR
authors.lastname: Silva
authors.affiliation: Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, 24020-15 Niterói, RJ, Brazil.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Burth
authors.affiliation: Departamento de Medicina Interna, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, 20550-900 Rio de Janeiro, RJ, Brazil.
authors.forename: Mauro Velho
authors.initials: MV
authors.lastname: Castro-Faria
authors.affiliation: Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (FIOCRUZ), 21040-900 Rio de Janeiro, RJ, Brazil.
authors.forename: Hugo Caire
authors.initials: HC
authors.lastname: Castro-Faria-Neto
mesh_terms: D000818:Animals; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000139:chemically induced* / Q000150:complications; D018836:Inflammation Mediators / Q000502:physiology; D055370:Lung Injury / Q000139:chemically induced* / Q000150:complications; D019301:Oleic Acid / Q000633:toxicity*; D011654:Pulmonary Edema / Q000503:physiopathology; D012128:Respiratory Distress Syndrome / Q000209:etiology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
chemical_list: D018836:Inflammation Mediators; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D019301:Oleic Acid; D000254:Sodium-Potassium-Exchanging ATPase