title: A Comparison of Five Different Treatment Regimens as the First-Line Treatment of Helicobacter pylori in Turkey.
abstract: BACKGROUND
  The H. pylori eradication success is low in countries with high antibiotic resistance to H. pylori.
  
  
  OBJECTIVE
  We retrospectively assessed the eradication rates achieved by five different regimens and aimed to compare the efficiency of bismuth enhanced sequential therapy and other treatments in a gastroenterology outpatient clinic a university-affiliated hospital.
  
  
  METHODS
  Our study was carried out with a retrospective cohort design.
  
  
  METHODS
  This study assessed the gastroscopy examinations of patients.
  
  
  METHODS
  A total of 621 patients were included in the study. There were 122 patients in the quadruple treatment group, 168 patients in the classical sequential treatment group, 130 patients in the bismuth enhanced sequential therapy, 113 patients in the sequential treatment with levofloxacin, and 88 patients in the hybrid treatment.
  
  
  METHODS
  Eradication rates of different regimens was analyzed by performing Chi-square and Tukey's honest significant difference test.
  
  
  RESULTS
  Eradication rates by ITT and PP analysis achieved by treatment groups were 74.6 and 75.6% in the quadruple treatment; 70.2 and 70.4% in the sequential treatment with clarithromycin, 88.5 and 90.3% in the bismuth enhanced sequential therapy, 77.9 and 78.5% in the sequential treatment with levofloxacin, and 76.1 and 76.2% in the hybrid treatment.
  
  
  CONCLUSIONS
  The main limitation of our study was its retrospective nature. Different proton pump inhibitors were used in the treatment arms.
  
  
  CONCLUSIONS
  Bismuth-enhanced sequential therapy can be recommended to overcome resistance.
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Baskent University, Konya, Turkey.
authors.forename: Gulhan Kanat
authors.initials: GK
authors.lastname: Unler
authors.affiliation: Department of Family Medicine, Faculty of Medicine, Baskent University, Konya, Turkey.
authors.forename: Gulsum
authors.initials: G
authors.lastname: Teke Ozgur
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Baskent University, Konya, Turkey.
authors.forename: Huseyin Savas
authors.initials: HS
authors.lastname: Gokturk
authors.affiliation: Department of Statistics, Faculty of Science, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Aydın
authors.initials: A
authors.lastname: Karakoca
authors.affiliation: Department of Pathology, Faculty of Medicine, Baskent University, Konya, Turkey.
authors.forename: Ozgur Hilal
authors.initials: OH
authors.lastname: Erinanc
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors
keywords: Eradication therapy; Helicobacter pylori; bismuth