title: On the Possibility of Electronic DNA Nanobiochips.
abstract: We have considered as a theoretical possibility for the development of a nanobiochip the operation principle of which is based on measuring conductance in single-stranded and double-stranded DNA. Calculations have demonstrated that in the majority of cases the conductance of double-stranded nucleotides considerably exceeds that of single-stranded ones. The results obtained are in agreement with recent experiments on measuring the oligonucleotide conductance. It has been shown that an electronic biochip containing 11 nucleotide pairs will recognize ≈97% sequences. It has also been demonstrated that the percentage of identifiable sequences will grow with the sequence length.
authors.affiliation: Institute of Mathematical Problems of Biology, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.
authors.forename: V D
authors.initials: VD
authors.lastname: Lakhno
authors.affiliation: Institute of Mathematical Problems of Biology, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.
authors.forename: V B
authors.initials: VB
authors.lastname: Sultanov