title: Single-Component Phosphinous Acid Ruthenium(II) Catalysts for Versatile C-H Activation by Metal-Ligand Cooperation.
abstract: Well-defined ruthenium(II) phosphinous acid (PA) complexes enabled chemo-, site-, and diastereoselective C-H functionalization of arenes and alkenes with ample scope. The outstanding catalytic activity was reflected by catalyst loadings as low as 0.75 mol %, and the most step-economical access reported to date to angiotensin II receptor antagonist blockbuster drugs. Mechanistic studies indicated a kinetically relevant C-X cleavage by a single-electron transfer (SET)-type elementary process, and provided evidence for a PA-assisted C-H ruthenation step.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Göttingen, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Zell
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Göttingen, Germany.
authors.forename: Svenja
authors.initials: S
authors.lastname: Warratz
authors.affiliation: Institute of Chemistry, The Hebrew University, Edmond Safra Campus, 91904, Jerusalem, Israel.
authors.forename: Dmitri
authors.initials: D
authors.lastname: Gelman
authors.affiliation: Department of Organic Chemistry, Instituto de Química, Universidade Federal do Rio de Janeiro, Cidade Universitaria, CT Bloco A, Ilha do Fundao, RJ, 21941-909, Brazil.
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Garden
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Göttingen, Germany. Lutz.Ackermann@chemie.uni-goettingen.de.
authors.forename: Lutz
authors.initials: L
authors.lastname: Ackermann
keywords: C−H activation; arylation; kinetics; reaction mechanisms; ruthenium