title: Solid pseudopapillary neoplasms of the pancreas: clinical analysis of 45 cases.
abstract: OBJECTIVE
  This study investigated the clinicopathological features and surgical management of solid pseudopapillary neoplasms (SPNs) at a single institution in China.
  
  
  METHODS
  We investigated 45 patients who underwent surgery for pathologically confirmed SPNs between 1996 and 2014.
  
  
  RESULTS
  The 45 cases included 44 female and 1 male patients, and the average age was 32.2 years. The tumor was located in the body and/or tail in 33 patients, the head in 9 patients and the neck in 3 patients. The median tumor size was 6.3 cm (range 1.5 to 16). All 45 patients had curative resections including 29 distal pancreatectomies, 9 pancreaticoduodenectomy, 5 central pancreatectomy and 2 enucleation. 2 patients required superior mesenteric vein resection due to local tumor invasion. Eight patients had malignant tumors. Ki-67 was detected positive in 5 patients with malignant potential. After a median follow-up of 51.7 months, one patient with malignant SPN had evidence of tumor recurrence.
  
  
  CONCLUSIONS
  SPN is an infrequent tumor, typically affect young women with low malignant potential. Surgical resection is warranted even in the presence of local invasion or metastases as patients demonstrate excellent long-term survival. Positive immunoreactivity for Ki-67 may predict the malignant potential and poor outcome of SPNs.
authors.affiliation: Department of Abdominal Surgery, Zhejiang Cancer Hospital Hangzhou 310022, China.
authors.forename: Gaiguo
authors.initials: G
authors.lastname: Dai
authors.affiliation: Department of Abdominal Surgery, Zhejiang Cancer Hospital Hangzhou 310022, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Abdominal Surgery, Zhejiang Cancer Hospital Hangzhou 310022, China.
authors.forename: Yian
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Abdominal Surgery, Zhejiang Cancer Hospital Hangzhou 310022, China.
authors.forename: Litao
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Abdominal Surgery, Zhejiang Cancer Hospital Hangzhou 310022, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002291:Carcinoma, Papillary / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000601:surgery; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen
keywords: Solid-pseudopapillary neoplasms; diagnosis; prognosis; treatment