title: Hydroxyflavanone inhibits gastric carcinoma MGC-803 cell proliferation.
abstract: Gastric carcinoma (GC) is the most common primary malignancy of the digestive tract, with increasing incidence in many countries. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to assess inhibition of HepG2 cell proliferation by 2'-hydroxyflavanone. The STAT3 pathway was performed. 2'-hydroxyflavanone reduced inhibitory effects on MGC-803 cell proliferation. 2'-hydroxyflavanone exhibited the highest inhibition rate. Treatment of MGC-803 cells with 400, 200, and 100 μg/ml 2'-hydroxyflavanone resulted in 88.9±0.7%, 81.2±0.5%, 68.4±0.5% decrease in cell viability, respectively, indicating an IC50 of 9.3 μg/ml. The 100 μg/ml 2'-hydroxyflavanone can significantly inhibit the STAT3 pathway activation. 2'-hydroxyflavanone inhibits MGC-803 cell proliferation by inhibiting STAT3 pathway activation. This extract is therefore a potential drug candidate for treatment of liver cancer.
authors.affiliation: Department of Gastrointestinal Surgery, China-Japan Union Hospital of Jilin University Changchun 130033, Jilin Province, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Gastrointestinal Surgery, China-Japan Union Hospital of Jilin University Changchun 130033, Jilin Province, China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Zhan
authors.affiliation: Department of Gastrointestinal Surgery, China-Japan Union Hospital of Jilin University Changchun 130033, Jilin Province, China.
authors.forename: Mingfu
authors.initials: M
authors.lastname: Cui
authors.affiliation: Department of Gastrointestinal Surgery, China-Japan Union Hospital of Jilin University Changchun 130033, Jilin Province, China.
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Gastrointestinal Surgery, China-Japan Union Hospital of Jilin University Changchun 130033, Jilin Province, China.
authors.forename: Dayu
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Gastrointestinal Surgery, China-Japan Union Hospital of Jilin University Changchun 130033, Jilin Province, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Feng
keywords: 2’-hydroxyflavanone; STAT3; gastric carcinoma