title: Interleukin-18: The Bouncer at the Mucosal Bar.
abstract: The fidelity of the intestinal barrier is critical to maintaining a healthy relationship between the immune system and the microbiota. Levy et al. and Nowarski et al. reveal how microbiota-derived metabolites modulate the activation of the inflammasome to influence the expression of the cytokine IL-18, intestinal barrier function, and intestinal inflammation.
authors.affiliation: Richard King Mellon Institute for Pediatric Research, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. Electronic address: timothy.hand@chp.edu.
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Hand
mesh_terms: D000818:Animals; D003093:Colitis, Ulcerative / Q000473:pathology* / Q000503:physiopathology*; D003106:Colon / Q000276:immunology* / Q000382:microbiology*; D005260:Female; D058847:Inflammasomes / Q000276:immunology*; D020382:Interleukin-18 / Q000276:immunology*; D008297:Male; D064307:Microbiota; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D058847:Inflammasomes; D020382:Interleukin-18; D011956:Receptors, Cell Surface