title: Isolated Lung Perfusion for Pulmonary Metastases.
abstract: Isolated lung perfusion (ILP) is a surgical technique developed to treat pulmonary metastases. During ILP, high-dose chemotherapy is delivered into the pulmonary vasculature, minimizing systemic exposure and delivering the chemotherapeutic agent directly to the lung. ILP has been studied extensively in a variety of animal models and in humans in phase I trials. The most frequently studied chemotherapeutic agents used in ILP are doxorubicin, 5-flurodeoxyuridine, tumor necrosis factor-α, paclitaxel, melphalan, gemcitabine, and cisplatin. Phase I clinical trials with ILP have shown that ILP can be safely performed in humans but with mixed clinical results and poor long-term survival.
authors.affiliation: Department of Cardiothoracic Surgery, NYU Langone Medical Center, 530 First Avenue, New York, NY 10016, USA.
authors.forename: Alison
authors.initials: A
authors.lastname: Ward
authors.affiliation: Department of Cardiothoracic Surgery, NYU Langone Medical Center, 530 First Avenue, New York, NY 10016, USA.
authors.forename: Kirill
authors.initials: K
authors.lastname: Prokrym
authors.affiliation: Department of Cardiothoracic Surgery, NYU Langone Medical Center, 530 First Avenue, New York, NY 10016, USA. Electronic address: harvey.pass@nyumc.org.
authors.forename: Harvey
authors.initials: H
authors.lastname: Pass
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D009362:Neoplasm Metastasis; D014409:Tumor Necrosis Factor-alpha
chemical_list: D000970:Antineoplastic Agents; D014409:Tumor Necrosis Factor-alpha
keywords: Chemotherapy; Isolated lung perfusion; Pulmonary artery perfusion; Pulmonary metastasis