title: [Malakoplakia of the submandibular gland in a renal transplant patient].
abstract: BACKGROUND
  Malakoplakia (MP) is a rare granulomatous disease, usually occurring in immunocompromised patients, linked to Escherichia coli infection. The lesions are usually located in the genitourinary tract, but there is a great variability in the topography and the clinical presentation.
  
  
  METHODS
  A 70-year-old diabetic kidney transplant patient under immunosuppressive treatment presented with a voluminous submandibular chronic lesion, involving the skin, associated with a burgeoning lesion of the oral mucosa. Histological examination of biopsies concluded to MP and bacteriological samples were positive for E. coli. Antibiotic treatment allowed for the regression of the lesion before surgical removal. Histological examination of resected material confirmed the diagnosis of invasive MP of the submandibular gland.
  
  
  CONCLUSIONS
  The diagnosis of MP relies on histological examination, showing the presence of von Hansemann's cells and Michaelis- Gutmann bodies. The treatment is based on active antibiotics targeted against intracellular bacteria, possibly associated with surgery. We report the first case of MP involving the submandibular gland.
authors.affiliation: Service de chirurgie maxillo-faciale, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, 5, rue Thomas-Mann, 75013 Paris, France. Electronic address: emilie.schwob@sls.aphp.fr.
authors.forename: E
authors.initials: E
authors.lastname: Schwob
authors.affiliation: Service de dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, 5, rue Thomas-Mann, 75013 Paris, France.
authors.forename: J-D
authors.initials: JD
authors.lastname: Bouaziz
authors.affiliation: Service de chirurgie maxillo-faciale, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, 5, rue Thomas-Mann, 75013 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Saussine
authors.affiliation: Service de chirurgie maxillo-faciale, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, 5, rue Thomas-Mann, 75013 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Bagot
authors.affiliation: Service de chirurgie maxillo-faciale, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, 5, rue Thomas-Mann, 75013 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Dionyssopoulos
authors.affiliation: Service de chirurgie maxillo-faciale, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, 5, rue Thomas-Mann, 75013 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Rigolet
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000276:immunology / Q000601:surgery; D004926:Escherichia coli / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation; D008287:Malacoplakia / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D008297:Male; D013363:Submandibular Gland / Q000382:microbiology / Q000473:pathology*; D013364:Submandibular Gland Diseases / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Glande sous-mandibulaire; Malakoplakia; Malakoplakie; Submandibular gland