title: Development of an Ointment Formulation Using Hot-Melt Extrusion Technology.
abstract: Ointments are generally prepared either by fusion or by levigation methods. The current study proposes the use of hot-melt extrusion (HME) processing for the preparation of a polyethylene glycol base ointment. Lidocaine was used as a model drug. A modified screw design was used in this process, and parameters such as feeding rate, barrel temperature, and screw speed were optimized to obtain a uniform product. The product characteristics were compared with an ointment of similar composition prepared by conventional fusion method. The rheological properties, drug release profile, and texture characteristics of the hot-melt extruded product were similar to the conventionally prepared product. This study demonstrates a novel application of the hot-melt extrusion process in the manufacturing of topical semi-solids.
authors.affiliation: Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677, USA.
authors.forename: Ajinkya M
authors.initials: AM
authors.lastname: Bhagurkar
authors.affiliation: Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677, USA.
authors.forename: Muralikrishnan
authors.initials: M
authors.lastname: Angamuthu
authors.affiliation: Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677, USA.
authors.forename: Hemlata
authors.initials: H
authors.lastname: Patil
authors.affiliation: Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677, USA.
authors.forename: Roshan V
authors.initials: RV
authors.lastname: Tiwari
authors.affiliation: Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677, USA.
authors.forename: Abhijeet
authors.initials: A
authors.lastname: Maurya
authors.affiliation: Dave C. Swalm School of Chemical Engineering, Mississippi State University, Oktibbeha County, Mississippi, 39762, USA.
authors.forename: Seyed Meysam
authors.initials: SM
authors.lastname: Hashemnejad
authors.affiliation: Dave C. Swalm School of Chemical Engineering, Mississippi State University, Oktibbeha County, Mississippi, 39762, USA.
authors.forename: Santanu
authors.initials: S
authors.lastname: Kundu
authors.affiliation: Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677, USA.
authors.forename: S Narasimha
authors.initials: SN
authors.lastname: Murthy
authors.affiliation: Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677, USA. marepka@olemiss.edu.|Pii Center for Pharmaceutical Technology, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677, USA. marepka@olemiss.edu.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Repka
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004337:Drug Carriers / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D065546:Drug Liberation; D006358:Hot Temperature; D009824:Ointments / Q000737:chemistry*; D012212:Rheology
chemical_list: D004337:Drug Carriers; D009824:Ointments
keywords: PEG; hot-melt extrusion; lidocaine; ointment; texture analyzer