title: Estimation of passive and active properties in the human heart using 3D tagged MRI.
abstract: Advances in medical imaging and image processing are paving the way for personalised cardiac biomechanical modelling. Models provide the capacity to relate kinematics to dynamics and-through patient-specific modelling-derived material parameters to underlying cardiac muscle pathologies. However, for clinical utility to be achieved, model-based analyses mandate robust model selection and parameterisation. In this paper, we introduce a patient-specific biomechanical model for the left ventricle aiming to balance model fidelity with parameter identifiability. Using non-invasive data and common clinical surrogates, we illustrate unique identifiability of passive and active parameters over the full cardiac cycle. Identifiability and accuracy of the estimates in the presence of controlled noise are verified with a number of in silico datasets. Unique parametrisation is then obtained for three datasets acquired in vivo. The model predictions show good agreement with the data extracted from the images providing a pipeline for personalised biomechanical analysis.
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, King's College London, 4th Floor, Lambeth Wing, London, SE1 7EH, UK. liya.asner@kcl.ac.uk.
authors.forename: Liya
authors.initials: L
authors.lastname: Asner
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, King's College London, 4th Floor, Lambeth Wing, London, SE1 7EH, UK.
authors.forename: Myrianthi
authors.initials: M
authors.lastname: Hadjicharalambous
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, King's College London, 4th Floor, Lambeth Wing, London, SE1 7EH, UK.|Inria Saclay Ile-de-France, MΞDISIM Team, Palaiseau, France.
authors.forename: Radomir
authors.initials: R
authors.lastname: Chabiniok
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, King's College London, 4th Floor, Lambeth Wing, London, SE1 7EH, UK.
authors.forename: Devis
authors.initials: D
authors.lastname: Peresutti
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, King's College London, 4th Floor, Lambeth Wing, London, SE1 7EH, UK.
authors.forename: Eva
authors.initials: E
authors.lastname: Sammut
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, King's College London, 4th Floor, Lambeth Wing, London, SE1 7EH, UK.
authors.forename: James
authors.initials: J
authors.lastname: Wong
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, King's College London, 4th Floor, Lambeth Wing, London, SE1 7EH, UK.|Department of Cardiology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
authors.forename: Gerald
authors.initials: G
authors.lastname: Carr-White
authors.affiliation: Department of Clinical Pharmacology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Chowienczyk
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, King's College London, 4th Floor, Lambeth Wing, London, SE1 7EH, UK.
authors.forename: Jack
authors.initials: J
authors.lastname: Lee
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, King's College London, 4th Floor, Lambeth Wing, London, SE1 7EH, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: King
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, King's College London, 4th Floor, Lambeth Wing, London, SE1 7EH, UK.|Faculty of Engineering, University of Auckland, Auckland, New Zealand.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Smith
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, King's College London, 4th Floor, Lambeth Wing, London, SE1 7EH, UK.
authors.forename: Reza
authors.initials: R
authors.lastname: Razavi
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, St Thomas' Hospital, King's College London, 4th Floor, Lambeth Wing, London, SE1 7EH, UK.
authors.forename: David
authors.initials: D
authors.lastname: Nordsletten
mesh_terms: D003198:Computer Simulation; D006321:Heart / Q000502:physiology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D013599:Systole / Q000502:physiology
keywords: 3D tagged MRI; Cardiac mechanics; Parameter estimation; Patient-specific modelling