title: The comparison of pathology in ferrets infected by H9N2 avian influenza viruses with different genomic features.
abstract: H9N2 avian influenza virus circulates widely in poultry and has been responsible for sporadic human infections in several regions. Few studies have been conducted on the pathogenicity of H9N2 AIV isolates that have different genomic features. We compared the pathology induced by a novel reassortant H9N2 virus and two currently circulating H9N2 viruses that have different genomic features in ferrets. The results showed that the three viruses can induce infections with various amounts of viral shedding in ferrets. The novel H9N2 induced respiratory infection, but no pathological lesions were observed in lung tissues. The other two viruses induced mild to intermediate pathological lesions in lung tissues, although the clinical signs presented mildly in ferrets. The pathological lesions presented a diversity consistent with viral replication in ferrets.
authors.affiliation: National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, China.
authors.forename: Rongbao
authors.initials: R
authors.lastname: Gao
authors.affiliation: National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Bai
authors.affiliation: National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Li
authors.affiliation: Jiangxi Provincial Disease Control and Prevention, Nanchang 330029, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: Hunan Provincial Disease Control and Prevention, Changsha, China.
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Sichuan Provincial Disease Control and Prevention, Chengdu 610041, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Pan
authors.affiliation: National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Bo
authors.affiliation: National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, China.
authors.forename: Shumei
authors.initials: S
authors.lastname: Zou
authors.affiliation: National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, China. Electronic address: yshu@cnic.org.cn.
authors.forename: Yuelong
authors.initials: Y
authors.lastname: Shu
mesh_terms: D000818:Animals; D001717:Birds; D004195:Disease Models, Animal; D005289:Ferrets; D014644:Genetic Variation; D006651:Histocytochemistry; D053127:Influenza A Virus, H9N2 Subtype / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity* / Q000502:physiology; D005585:Influenza in Birds; D008168:Lung / Q000473:pathology; D008297:Male; D008853:Microscopy; D009976:Orthomyxoviridae Infections / Q000473:pathology* / Q000821:virology*; D016865:Reassortant Viruses / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D014779:Virus Replication; D017201:Virus Shedding
keywords: Avian influenza virus; H9N2; Pathogenicity; Pathology