title: Androgen receptor CAG and GGN repeat polymorphisms influence performance in boys and girls.
abstract: BACKGROUND
  Shorter CAG and GGN androgen receptor (AR) repeat polymorphisms are associated with stronger androgen signaling, and therefore, could influence lean mass and exercise performance during growth.
  
  
  METHODS
  Physical fitness and body composition were measured by standardized procedures and the length of CAG and GGN repeats was determined by PCR and fragment analysis in 152 boys (11.5±2.6 years; Tanner ≤5) and 116 girls (10.1±3.2 years; Tanner ≤5). Individuals were grouped as CAG short (CAGS) if harboring repeat lengths of ≤21 and CAG long (CAGL) if CAG >21. Moreover, subjects were grouped as GGN short (GGNS) if harboring repeat lengths of ≤23 and GGN long (GGNL) if GGN>23.
  
  
  RESULTS
  No significant differences in anthropometrics and body composition were observed between either CAGS and CAGL groups and GGNS and GGNL groups. Boys harboring CAGS completed the 300-meter test faster than their CAGL counterparts. Moreover, girls from the GGNL group showed a significant higher VO2max than those in the GGNS group.
  
  
  CONCLUSIONS
  In summary, carrying a short allele of the androgen receptor CAG repeat polymorphism is associated to higher anaerobic performance in boys, whereas long alleles of androgen receptor GGN polymorphisms are associated to higher aerobic capacity in girls.
authors.affiliation: Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: Lorena
authors.initials: L
authors.lastname: Rodríguez-García
authors.affiliation: Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: Jesús G
authors.initials: JG
authors.lastname: Ponce-González
authors.affiliation: Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Department of Mathematics, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: González-Henríquez
authors.affiliation: Department of Biochemistry and Physiology, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Canary Islands Cancer Research Institute (ICIC), Las Palmas de Gran Canaria, Spain.
authors.forename: Francisco G
authors.initials: FG
authors.lastname: Rodríguez-González
authors.affiliation: Department of Biochemistry and Physiology, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Canary Islands Cancer Research Institute (ICIC), Las Palmas de Gran Canaria, Spain.
authors.forename: Bonifacio N
authors.initials: BN
authors.lastname: Díaz-Chico
authors.affiliation: Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Calbet
authors.affiliation: Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Dorado
authors.affiliation: Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain - amelia.guadalupe@gmail.com.
authors.forename: Amelia
authors.initials: A
authors.lastname: Guadalupe-Grau
mesh_terms: D000293:Adolescent; D001823:Body Composition / Q000235:genetics*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010455:Peptides / Q000235:genetics; D010809:Physical Fitness; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011944:Receptors, Androgen / Q000235:genetics*; D018911:Trinucleotide Repeats / Q000502:physiology*
chemical_list: C410798:AR protein, human; D010455:Peptides; D011944:Receptors, Androgen; C011080:polyglycine; C097188:polyglutamine