title: Association between alcohol dehydrogenase 1C gene *1/*2 polymorphism and pancreatitis risk: a meta-analysis.
abstract: Numerous studies have focused on the relationship be-tween alcohol dehydrogenase 1C gene (ADH1C) *1/*2 polymorphism (Ile350Val, rs698, also known as ADH1C *1/*2) and pancreatitis risk, but the results have been inconsistent. Thus, we conducted a meta-anal-ysis to more precisely estimate this association. Relevant publications were searched in several widely used databases and 9 eligible studies were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Significant associations between ADH1C *1/*2 poly-morphism and pancreatitis risk were observed in both overall meta-analysis for 12 vs 22 (OR = 1.53, 95%CI = 1.12-2.10) and 11 + 12 vs 22 (OR = 1.44, 95%CI = 1.07-1.95), and the chronic alcoholic pancre-atitis subgroup for 12 vs 22 (OR = 1.64, 95%CI = 1.17-2.29) and 11 + 12 vs 22 (OR = 1.53, 95%CI = 1.11-2.11). Significant pancreatitis risk variation was also detected in Caucasians for 11 + 12 vs 22 (OR = 1.45, 95%CI = 1.07-1.98). In conclusion, the ADH1C *1/*2 polymorphism is likely associated with pancreatitis risk, particularly chronic alcoholic pancreatitis risk, with the *1 allele functioning as a risk factor.
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
authors.forename: F
authors.initials: F
authors.lastname: Fang
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Pan
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
authors.forename: G H
authors.initials: GH
authors.lastname: Su
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
authors.forename: L X
authors.initials: LX
authors.lastname: Xu
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
authors.forename: G
authors.initials: G
authors.lastname: Li
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Li
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Wang
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000483:Alleles; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D010195:Pancreatitis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: C420272:ADH1C protein, human; D000426:Alcohol Dehydrogenase