title: Regulatory T lymphocytes in myocardial infarction: A promising new therapeutic target.
abstract: Myocardial infarction (MI) is one of the leading causes of death especially in developed countries. Although the advent of early myocardial reperfusion therapy contributes to decreasing the mortality of patients with MI, cardiac ischemia-reperfusion injury and adverse remodeling during the repair process still remain the major factors impairing cardiac function and resulting in unsatisfactory prognosis. Excessive inflammation and immune responses play a crucial role during the whole process of MI. Regulatory T lymphocytes, characterized by immunosuppressive capacity, are associated with many immune-related diseases. Recent studies have proven a protective role of regulatory T cells in MI, which is mainly achieved by modulating inflammation and immune responses. In this review, we will summarize current knowledge of regulatory T lymphocytes, and highlight their roles in the onset of MI, ischemia-reperfusion injury, as well as post-infarct cardiac healing and remodeling.
authors.affiliation: Department of Cardiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Cardiovascular Key Lab of Zhejiang Province, #88 Jiefang Road, Hangzhou, Zhejiang, 310009, China.
authors.forename: Ya-ping
authors.initials: YP
authors.lastname: Wang
authors.affiliation: Cardiovascular Division, King's College London BHF Center, London, United Kingdom.
authors.forename: Yao
authors.initials: Y
authors.lastname: Xie
authors.affiliation: McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Cardiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Cardiovascular Key Lab of Zhejiang Province, #88 Jiefang Road, Hangzhou, Zhejiang, 310009, China.
authors.forename: Sheng-an
authors.initials: SA
authors.lastname: Su
authors.affiliation: Department of Cardiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Cardiovascular Key Lab of Zhejiang Province, #88 Jiefang Road, Hangzhou, Zhejiang, 310009, China.
authors.forename: Yi-dong
authors.initials: YD
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Cardiovascular Key Lab of Zhejiang Province, #88 Jiefang Road, Hangzhou, Zhejiang, 310009, China.
authors.forename: Jian-an
authors.initials: JA
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Cardiovascular Key Lab of Zhejiang Province, #88 Jiefang Road, Hangzhou, Zhejiang, 310009, China. Electronic address: xiangmxhz@163.com.
authors.forename: Mei-xiang
authors.initials: MX
authors.lastname: Xiang
mesh_terms: D006801:Humans; D007111:Immunity, Cellular; D009203:Myocardial Infarction / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D015425:Myocardial Reperfusion / Q000379:methods*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D020257:Ventricular Remodeling / Q000502:physiology*
keywords: Ischemia-reperfusion injury; Myocardial infarction; Plaque instability; Regulatory T lymphocyte; Ventricular remodeling