title: Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells: a rare case report and review of the literature.
abstract: Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UCPOGC) is an extremely rare non-endocrine pancreatic tumor. To date, some cases have been reported, however, histogenesis and biologic behavior of UCPOGC remain controversial. We report a case of an UCPOGC in a 54-year-old female, who presented with a three-month history of recurrent abdominal pain without any incentive. Abdominal computed tomography (CT) revealed a large cystic mass of 10.5 × 9.3 cm in the body and tail of the pancreas compressing the adjacent bowel loop and stomach. The preliminary diagnosis was considered as a malignant tumor of body and tail of the pancreas. The patient had open distal pancreatic mass resection with splenectomy and according to the results of histopathological and immunohistochemical studies, the diagnosis of an UCPOGC was established.
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Chongqing Medical University Chongqing 400016, China.
authors.forename: Shambhu K
authors.initials: SK
authors.lastname: Sah
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Chongqing Medical University Chongqing 400016, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Chongqing Medical University Chongqing 400016, China.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D005260:Female; D005870:Giant Cell Tumors / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010010:Osteoclasts / Q000737:chemistry / Q000473:pathology*; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013156:Splenectomy; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor
keywords: Osteoclast-like giant cells; pancreas; undifferentiated carcinoma