title: Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity.
abstract: OBJECTIVE
  To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE).
  
  
  METHODS
  A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and maternal age. Samples were taken in gestational weeks 10+0-13+6.
  
  
  RESULTS
  There was a negative correlation between resistin and clinical severity of PE, but no correlation with IS, TNF-α, body mass index, birth weight and pregnancy length.
  
  
  CONCLUSIONS
  Resistin is reduced in first trimester of PE pregnancies, particularly in severe PE. Inflammation and IS cannot explain this phenomenon.
authors.affiliation: a Department of Clinical Biochemistry , Statens Serum Institut , Copenhagen , Denmark .
authors.forename: Michael
authors.initials: M
authors.lastname: Christiansen
authors.affiliation: a Department of Clinical Biochemistry , Statens Serum Institut , Copenhagen , Denmark .|b Department of Biomedical Sciences , Stellenbosch University , Cape Town , South Africa .
authors.forename: Paula L
authors.initials: PL
authors.lastname: Hedley
authors.affiliation: a Department of Clinical Biochemistry , Statens Serum Institut , Copenhagen , Denmark .
authors.forename: Sophie
authors.initials: S
authors.lastname: Placing
authors.affiliation: c Department of Fetal Medicine , Rigshospitalet , Copenhagen , Denmark .|d Department of Obstetrics and Gynecology , Roskilde Hospital , Roskilde , Denmark .
authors.forename: Karen R
authors.initials: KR
authors.lastname: Wøjdemann
authors.affiliation: a Department of Clinical Biochemistry , Statens Serum Institut , Copenhagen , Denmark .
authors.forename: Anting L
authors.initials: AL
authors.lastname: Carlsen
authors.affiliation: a Department of Clinical Biochemistry , Statens Serum Institut , Copenhagen , Denmark .
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Jørgensen
authors.affiliation: c Department of Fetal Medicine , Rigshospitalet , Copenhagen , Denmark .|e Department of Obstetrics and Gynecology , Hillerød Hospital , Hillerød , Denmark.
authors.forename: Anne-Cathrine
authors.initials: AC
authors.lastname: Gjerris
authors.affiliation: c Department of Fetal Medicine , Rigshospitalet , Copenhagen , Denmark .|e Department of Obstetrics and Gynecology , Hillerød Hospital , Hillerød , Denmark.
authors.forename: Anne-Cathrine
authors.initials: AC
authors.lastname: Shalmi
authors.affiliation: c Department of Fetal Medicine , Rigshospitalet , Copenhagen , Denmark .
authors.forename: Line
authors.initials: L
authors.lastname: Rode
authors.affiliation: c Department of Fetal Medicine , Rigshospitalet , Copenhagen , Denmark .
authors.forename: Karin
authors.initials: K
authors.lastname: Sundberg
authors.affiliation: c Department of Fetal Medicine , Rigshospitalet , Copenhagen , Denmark .
authors.forename: Ann
authors.initials: A
authors.lastname: Tabor
keywords: placenta; pre-eclampsia; prenatal screening