title: Single dose of diclofenac or meloxicam for control of pain, facial swelling, and trismus in oral surgery.
abstract: BACKGROUND
  Postoperative pain associated with removal of mandibular third molars has been documented from moderate to severe during the first 24 hours after surgery, with pain peaking between 6 and 8 hours when a conventional local anesthetic is used. Dental pain is largely inflammatory, and evidence-based medicine has shown that nonsteroidal anti-inflammatory drugs are the best analgesics for dental pain. The aim of this study was to compare the analgesic, anti-inflammatory and anti-trismus effect of a single dose of diclofenac and meloxicam after mandibular third molar extraction.
  
  
  METHODS
  A total of 36 patients were randomized into two treatment groups, each with 18 patients, using a series of random numbers: Group A, was administered 100 mg of diclofenac; and Group B, 15 mg of meloxicam. Drugs were administered orally 1 hour prior to surgery. We evaluated pain intensity, analgesic consumption, swelling, as well as trismus.
  
  
  RESULTS
  The results of this study showed that patients receiving 15 mg of meloxicam had less postoperative pain (P=0.04) and better aperture than those receiving 100 mg of diclofenac (P=0.03). The meloxicam group presented less swelling than diclofenac group; however, significant statistical differences were not observed.
  
  
  CONCLUSIONS
  Data of this double-blind, randomized, parallel-group clinical trial demonstrated that patients receiving 15 mg of preoperative meloxicam had a better postoperative analgesia and anti-trismus effect compared with who were given 100 mg of diclofenac after third molar extractions.
authors.affiliation: Facultad de Odontología, Universidad Autónoma de Baja California, Calle Zotoluca y Chinampas s/n, Fraccionamiento Calafia, C.P. 21040; Mexicali, México, isiordia81@yahoo.com.mx.
authors.forename: Mariana
authors.initials: M
authors.lastname: Orozco-Solís
authors.forename: Yazmín
authors.initials: Y
authors.lastname: García-Ávalos
authors.forename: Celeste
authors.initials: C
authors.lastname: Pichardo-Ramírez
authors.forename: Francisco
authors.initials: F
authors.lastname: Tobías-Azúa
authors.forename: Juan-Ramón
authors.initials: JR
authors.lastname: Zapata-Morales
authors.forename: Othoniel-Hugo
authors.initials: OH
authors.lastname: Aragon-Martínez
authors.forename: Mario-Alberto
authors.initials: MA
authors.lastname: Isiordia-Espinoza
mesh_terms: D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D004008:Diclofenac / Q000008:administration & dosage*; D004311:Double-Blind Method; D004487:Edema / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D000077239:Meloxicam; D008964:Molar, Third / Q000601:surgery*; D010149:Postoperative Pain / Q000209:etiology / Q000517:prevention & control*; D013843:Thiazines / Q000008:administration & dosage*; D013844:Thiazoles / Q000008:administration & dosage*; D014081:Tooth Extraction / Q000009:adverse effects; D014313:Trismus / Q000209:etiology / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D004008:Diclofenac; D000077239:Meloxicam