title: Matrine promotes the efficacy and safety of platinum-based doublet chemotherapy for advanced non-small cell lung cancer.
abstract: OBJECTIVE
  Many studies have investigated the efficacy of matrine combined with platinum-based doublet chemotherapy (PBDC) versus PBDC alone for treating advanced non-small cell lung cancer (NSCLC). This study is an analytic value of available evidence.
  
  
  METHODS
  twenty-two studies reporting matrine combined with PBDC versus PBDC alone for treating advanced NSCLC were reviewed. Pooled odds ratios and hazard ratio with 95% confidence intervals were calculated using either the fixed effects model or random effects model.
  
  
  RESULTS
  The overall response rate (ORR) and disease control rate (DCR) of matrine combined with PBDC for treating NSCLC were significantly higher than those of PBDC alone, with 15.1% and 19.7% improvement, respectively (P < 0.00001). In addition, the mean survival time (MST) and quality of life (QOL) were improved after the treatment of matrine combined with PBDC (P < 0.00001). The main adverse effects found in this review were hematological reactions, nausea and vomiting. Matrine combined with PBDC had a lower incidence of adverse reactions compared with PBDC alone (P < 0.05).
  
  
  CONCLUSIONS
  Matrine combined with PBDC was associated with higher RR, DCR, and MST as well as superior QOL profiles compared with PBDC alone. Matrine combined with PBDC decrease the incidence of adverse reactions compared with PBDC alone.
authors.affiliation: Department of Oncology, The First Affiiated Hospital of Xi'an Medical University Xi'an, China.
authors.forename: Biaoxue
authors.initials: B
authors.lastname: Rong
authors.affiliation: Department of Neurology, Lanzhou University Second Hospital Lanzhou, China.
authors.forename: Chongchong
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Statistics and Epidemiology, Medical College, Lanzhou University Lanzhou, China.
authors.forename: Wenlong
authors.initials: W
authors.lastname: Gao
authors.affiliation: Department of Oncology, The First Affiiated Hospital of Xi'an Medical University Xi'an, China.
authors.forename: Shuanying
authors.initials: S
authors.lastname: Yang
keywords: Matrine; first-line chemotherapy; lung cancer; meta-analysis