title: Supplemental fermented plant product ('Manda Koso') reduces succinate and deoxycholate, as well as elevates IgA and mucin levels, in rats fed a high-fat diet.
abstract: 'Manda Koso' is a commercial fermented plant product (FPP) made from 53 types of fruits and vegetables that have been fermented for >3 years and 3 months. We hypothesized that FPP intake improves the luminal environment of rats fed a high-fat diet. Thus, the present study examined the effects of consumption of 5% FPP diet for 3 weeks on colonic luminal parameters in rats fed a 30% beef tallow diet. Food intake and body weight gain were unaffected. Consumption of the FPP diet did not influence the proportions ofBifidobacterium,Lactobacillus,Bacteroides,PrevotellaorClostridiumin cecal contents. However, the FPP diet caused a significant reduction (-88%) in the level of cecal succinate, a putative inflammatory signal (P<0.01), but did not affect the levels ofn-butyrate, propionate, acetate and lactate. The fecal levels of deoxycholate and hyodeoxycholate, which are toxic bile acids, were also significantly reduced by the FPP diet (P<0.05). The FPP diet significantly increased fecal immunoglobulin A and mucins responsible for intestinal immune and barrier functions (P<0.05). The results suggest that the consumption of FPP is beneficial for the colonic luminal environment in rats fed a high-fat diet.
authors.affiliation: Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8528, Japan.
authors.forename: Yongshou
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8528, Japan.
authors.forename: Novita Vivi
authors.initials: NV
authors.lastname: Sitanggang
authors.affiliation: Faculty of Human Life Sciences, Fuji Women's University, Ishikari 061-3204, Japan.
authors.forename: Yukako
authors.initials: Y
authors.lastname: Okazaki
authors.affiliation: Iida Women's Junior College, Iida 395-0812, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tomotake
authors.affiliation: Manda Fermentation Co., Ltd., Onomichi, Hiroshima 722-2192, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Arita
authors.affiliation: Manda Fermentation Co., Ltd., Onomichi, Hiroshima 722-2192, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ashida
authors.affiliation: Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8528, Japan.
authors.forename: Norihisa
authors.initials: N
authors.lastname: Kato
keywords: deoxycholate; fermented plant product; immunoglobulin A; mucins; succinate