title: Epidemiology and genotype distribution of high risk human papillomavirus in population of hospital opportunistic screening.
abstract: This study aimed to determine the prevalence of high-risk human papillomavirus (HR-HPV) in population of hospital opportunistic screening and to identify the correlation of prevalent genotypes and cervical cytological abnormalities. A cross-sectional study was employed between July 2013 and July 2014 in the Chaoyang hospital, in Beijing. Cervical samples were collected for the Type-specific HPV and the cervical cytological analyses in the population of hospital opportunistic screening. Total of 8975 samples from female patients aged 17-86 years were tested. Of these, 10.4% were infected by HR-HPV, the highest prevalence of HR-HPV in the youngest group and decreasing with aging (X(2)=19.68, P=0.02). Of these, 78.73% were single infections and 21.27% were multiple infections. Age-specific prevalence of multiple HPV exhibited a "U" shaped curve (X(2)=19.98, P=0.018). The most prevalent genotype is HPV 52, then descending order of frequency were HPV-58, 16, 39, 51, 56, 59, 18, 31, 33, 35, 68 and 45. 15.9% had an abnormal cytology in HR-HPV positive women, vs 4.13% in HR-HPV negative women. The prevalence of HR-HPV were 9.2%, 26.8%, 32%, 35.3% and 36.4% in normal cell, ASCUS, LSIL, ASC-H and HSIL, respectively (X(2)=234.67, P=0.000). Women with HPV 52, 16, 18, 58, 39, 51, 59, 56, 33, 31 infections related to the abnormal cytology, while the HPV68, 45, 35 didn't. The prevalent characteristic in population of the hospital opportunistic screening is similar to the population of cervical screen, But the most five prevalent genotype in rank are different .Women with HR-HPV infections were more likely to have the cervical abnormal cytology.
authors.affiliation: Department of Obstetrics and Gynecology, Luohe Teaching Hospital Affiliated to Capital Medical University Beijing 101100, China.
authors.forename: Ying-Qiao
authors.initials: YQ
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020, China.
authors.forename: Xin
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Obstetrics and Gynecology, Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020, China.
authors.forename: Sha-Sha
authors.initials: SS
authors.lastname: Xu
authors.affiliation: Department of Clinical Laboratory, Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020, China.
authors.forename: Jiu-Xin
authors.initials: JX
authors.lastname: Qu
authors.affiliation: Department of Pathology, Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Pathology, Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Diao
authors.affiliation: Department of Obstetrics and Gynecology, Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020, China.
authors.forename: Shu-Zhen
authors.initials: SZ
authors.lastname: Wang
keywords: High risk human papillomavirus; cervical cytology; epidemiology; population of hospital opportunistic screening