title: Direct Conversion Provides Old Neurons from Aged Donor's Skin.
abstract: Modeling human neuronal aging at a cellular level remains challenging. Human neurons are accessible from iPSCs, but during reprogramming age-associated traits of somatic cells get lost. In this issue of Cell Stem Cell, Mertens et al. (2015) demonstrate that neurons obtained by direct cell conversion retain age-associated transcriptional traits and functional deficits of the donor cell population.
authors.affiliation: Institute of Reconstructive Neurobiology, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany. Electronic address: philipp.koch@uni-bonn.de.
authors.forename: Philipp
authors.initials: P
authors.lastname: Koch
mesh_terms: D000375:Aging; D002454:Cell Differentiation; D065150:Cellular Reprogramming; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D009474:Neurons; D013234:Stem Cells; D014019:Tissue Donors