title: Significant Association Between Adiponutrin and Hepatocellular Carcinoma Risk.
abstract: ADPN I148M polymorphism has been consistently reported to play a role in liver-associated diseases, such as alcoholic liver disease, chronic hepatitis C, and liver fat and fibrosis in nonalcoholic fatty liver disease. This significant association was also indicated in a series of hepatocellular carcinoma (HCC) studies, where the significance may be affected due to the small sample sizes. The aim of this study was to reexamine the ADPN-HCC association by use of meta-analysis. Biweekly computer-based literature searches plus manual screening were undertaken in an effort to identify all studies that met the predefined inclusion criteria. The Mantel-Haenszel method was selected to estimate risk effects (odds ratio [OR] and 95% confidence interval [CI]). To examine reliability of the pooled risk effects, we additionally performed sensitivity analysis and publication bias tests. Ten studies (1335 HCC patients and 2927 HCC-free controls) were identified for the meta-analysis. We found significantly increased risk of HCC attributable to presence of ADPN I148M polymorphism, with the highest risk associated with the M/M genotype under the recessive model of inheritance (OR = 2.23, 95% CI = 1.87-2.67, between-study heterogeneity: P = 0.468). The significant increase persisted in Caucasian and African when data were stratified by ethnicity. Subgroup analysis according to source of controls revealed similar risk effects. Our meta-analysis indicates that I148M polymorphism in the ADPN gene may independently contribute to the progression of HCC irrespective of the etiologies.
authors.affiliation: From the Department of Hepatobiliary Surgery (H-GL, F-FL, H-QZ, XZ, JL, HC) and Department of Gastroenterology Surgery (J-HH), Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
authors.forename: Hong-Guang
authors.initials: HG
authors.lastname: Li
authors.forename: Fang-Feng
authors.initials: FF
authors.lastname: Liu
authors.forename: Hua-Qiang
authors.initials: HQ
authors.lastname: Zhu
authors.forename: Xu
authors.initials: X
authors.lastname: Zhou
authors.forename: Jun
authors.initials: J
authors.lastname: Lu
authors.forename: Hong
authors.initials: H
authors.lastname: Chang
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Hu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D008049:Lipase / Q000235:genetics*; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology; D008565:Membrane Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent
chemical_list: D008049:Lipase; D008565:Membrane Proteins; C533682:PNPLA3 protein, human; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent