title: Antidepressive-like effects and antioxidant activity of green tea and GABA green tea in a mouse model of post-stroke depression.
abstract: METHODS
  Growing evidence suggests that oxidative stress plays a role in the development of chronic diseases such as cardiovascular disease and some psychiatric disorders. Tea consumption exerts beneficial effects against damage induced by cerebral ischemia-reperfusion in ischemic stroke and depressive symptoms in depression. The aim of this study was to evaluate, in vivo, the protective activity of green tea (GT) and GABA green tea (GGT) against post-stroke depression (PSD), a common consequence of stroke.
  
  
  RESULTS
  The antidepressive-like effects of GT and GGT were determined by behavioral tests in a mouse model of post-stroke depression. The antioxidant activity was evaluated by GSH, SOD, and TBARS measurements on mouse brain. The chemical composition of tea extracts was characterized through chromatographic methods. GGT and GT resulted active in the modulation of depressive symptoms and the reduction of oxidative stress, restoring normal behavior, and at least in part, antioxidant endogenous defenses. The higher polyphenol, theanine, glutamine, and caffeine content may justify the higher activity found in GGT.
  
  
  CONCLUSIONS
  This work represents the first attempt to demonstrate the positive effect of tea, and especially GGT, on post-stroke depression and to correlate this effect with the antioxidant activity and phytochemical composition of tea.
authors.affiliation: Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Viale Taramelli 12, Pavia, Italy.
authors.forename: Arianna
authors.initials: A
authors.lastname: Di Lorenzo
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Fazel
authors.initials: SF
authors.lastname: Nabavi
authors.affiliation: Grup de Nutrició Comunitària i Estrès Oxidatiu (IUNICS) and CIBEROBN (Physiopathology of Obesity and Nutrition) Universitat de les Illes Balears, Palma de Mallorca, Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Sureda
authors.affiliation: Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Iran.
authors.forename: Akbar Hajizadeh
authors.initials: AH
authors.lastname: Moghaddam
authors.affiliation: Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Iran.
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Khanjani
authors.affiliation: Centro Grandi Strumenti, University of Pavia, Pavia, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Arcidiaco
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Nabavi
authors.affiliation: Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Viale Taramelli 12, Pavia, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Daglia
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D028241:Camellia sinensis / Q000737:chemistry; D003863:Depression / Q000178:diet therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D008297:Male; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D020521:Stroke / Q000150:complications / Q000523:psychology*; D013662:Tea / Q000737:chemistry; D005680:gamma-Aminobutyric Acid / Q000032:analysis / Q000494:pharmacology*
chemical_list: D000928:Antidepressive Agents; D000975:Antioxidants; D010936:Plant Extracts; D013662:Tea; D005680:gamma-Aminobutyric Acid
keywords: Antidepressive-like effects; GABA green tea; Green tea; In vivo antioxidant activity; Post-stroke depression