title: Ccr4-Not is at the core of the eukaryotic gene expression circuitry.
abstract: In this mini-review, we summarize our current knowledge about the cross-talk between the different levels of gene expression. We introduce the Ccr4 (carbon catabolite repressed 4)-Not (negative on TATA-less) complex as a candidate to be a master regulator that orchestrates between the different levels of gene expression. An integrated view of the findings about the Ccr4-Not complex suggests that it is involved in gene expression co-ordination. Since the discovery of the Not proteins in a selection for transcription regulators in yeast [Collart and Struhl (1994) Genes Dev. 8: , 525-537], the Ccr4-Not complex has been connected to every step of the mRNA lifecycle. Moreover, it has been found to be relevant for appropriate protein folding and quaternary protein structure by being involved in co-translational protein complex assembly.
authors.affiliation: Department of Microbiology and Molecular Medicine, University of Geneva, Faculty of Medicine, 1 Rue Michel-Servet, 1206 Geneva, Switzerland.
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Villanyi
authors.affiliation: Department of Microbiology and Molecular Medicine, University of Geneva, Faculty of Medicine, 1 Rue Michel-Servet, 1206 Geneva, Switzerland Martine.Collart@unige.ch.
authors.forename: Martine A
authors.initials: MA
authors.lastname: Collart
mesh_terms: D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism; D005786:Gene Expression Regulation; D008957:Models, Genetic; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D012260:Ribonucleases / Q000235:genetics* / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: C089931:CDC36 protein, S cerevisiae; C079592:CDC39 protein, S cerevisiae; D018797:Cell Cycle Proteins; D046912:Multiprotein Complexes; D012333:RNA, Messenger; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; C078657:CCR4 protein, S cerevisiae; D012260:Ribonucleases
keywords: Ccr4–Not; co-translational complex assembly; gene expression buffering; gene expression circuitry; messenger ribonucleic acid (mRNA) imprinting; protein homoeostasis