title: MicroRNA-506 inhibits esophageal cancer cell proliferation via targeting CREB1.
abstract: MicroRNAs (miRNAs) act as key regulators of multiple cancers. MicroRNA-506 (miR-506) functions as a tumor suppressor in various types of cancers. However, its role in esophageal cancer remains unclear. In our study, we found that miR-506 was significantly down-regulated in esophageal cancer tissues and cell lines. In vitro assay, our results showed that ectopic over-expression of miR-506 inhibited esophageal cancer cells proliferation, meanwhile, cells proliferation was promoted by miR-506 inhibition. In exploring mechanisms underlying the inhibitive role, we found that miR-506 significantly decreased the expression and transcription activity of cAMP responsive element binding protein 1 (CREB1). CREB1, tumor oncogene, exhibited significantly promote effect on esophageal cancer cell proliferation. Taken together, our data identify a new role of miR-506 in esophageal cancer involving CREB1 suppression.
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, China.
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Yao
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, China.
authors.forename: Yong-Lian
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, China.
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Lu
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Qi
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, China.
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D020413:3' Untranslated Regions; D001665:Binding Sites; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D013997:Time Factors; D014158:Transcription, Genetic; D014162:Transfection
chemical_list: D020413:3' Untranslated Regions; C115163:CREB1 protein, human; D017362:Cyclic AMP Response Element-Binding Protein; C561508:MIRN506 microRNA, human; D035683:MicroRNAs
keywords: CAMP responsive element binding protein 1; esophageal cancer; miR-506; proliferation