title: Circulating RNA: looking at the liver through a frosted glass.
abstract: BACKGROUND
  The evaluation of the liver condition, based on serum enzymatic activity and biopsies, is insufficient. Therefore, it is a priority to find a correlation between circulating RNAs and liver damage.
  
  
  METHODS
  Publications were retrieved by the search terms "circulating RNA AND liver".
  
  
  RESULTS
  Although differences exist between studies, a profile of RNAs that repeatedly appeared as indicators of liver damage was identified.
  
  
  CONCLUSIONS
  We highlight those circulating RNAs useful to diagnostic, and discuss the transport mechanisms.
  
  
  CONCLUSIONS
  Several studies have proven that circulating RNAs are useful to establish a diagnostic and a prognosis of liver diseases.
authors.affiliation: a Metabolomics Unit, CIC bioGUNE, CIBERehd, Technology Park of Bizkaia , Derio, Bizkaia , Spain and.|b IKERBASQUE, Basque Foundation for Science , Bilbao , Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Falcon-Perez
authors.affiliation: a Metabolomics Unit, CIC bioGUNE, CIBERehd, Technology Park of Bizkaia , Derio, Bizkaia , Spain and.
authors.forename: F
authors.initials: F
authors.lastname: Royo
mesh_terms: D015415:Biomarkers / Q000097:blood*; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis; D020869:Gene Expression Profiling; D006801:Humans; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000097:blood* / Q000175:diagnosis; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D011379:Prognosis
chemical_list: D015415:Biomarkers; C531907:MIRN122 microRNA, human; D035683:MicroRNAs
keywords: Blood; extracellular vesicles; hepatic diseases; miRNA