title: Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) - short version.
abstract: In 2010, under the guidance of the DGAI (German Society of Anaesthesiology and Intensive Care Medicine) and DIVI (German Interdisciplinary Association for Intensive Care and Emergency Medicine), twelve German medical societies published the "Evidence- and Consensus-based Guidelines on the Management of Analgesia, Sedation and Delirium in Intensive Care". Since then, several new studies and publications have considerably increased the body of evidence, including the new recommendations from the American College of Critical Care Medicine (ACCM) in conjunction with Society of Critical Care Medicine (SCCM) and American Society of Health-System Pharmacists (ASHP) from 2013. For this update, a major restructuring and extension of the guidelines were needed in order to cover new aspects of treatment, such as sleep and anxiety management. The literature was systematically searched and evaluated using the criteria of the Oxford Center of Evidence Based Medicine. The body of evidence used to formulate these recommendations was reviewed and approved by representatives of 17 national societies. Three grades of recommendation were used as follows: Grade "A" (strong recommendation), Grade "B" (recommendation) and Grade "0" (open recommendation). The result is a comprehensive, interdisciplinary, evidence and consensus-based set of level 3 guidelines. This publication was designed for all ICU professionals, and takes into account all critically ill patient populations. It represents a guide to symptom-oriented prevention, diagnosis, and treatment of delirium, anxiety, stress, and protocol-based analgesia, sedation, and sleep-management in intensive care medicine.
authors.affiliation: German Society of Neurology (DGN).
authors.forename: Ralf
authors.initials: R
authors.lastname: Baron
authors.affiliation: German Society of Neurology (DGN).
authors.forename: Andreas
authors.initials: A
authors.lastname: Binder
authors.affiliation: German Society of Neurology (DGN).
authors.forename: Rolf
authors.initials: R
authors.lastname: Biniek
authors.affiliation: German Society of Internal Medicine Intensive Care (DGIIN).
authors.forename: Stephan
authors.initials: S
authors.lastname: Braune
authors.affiliation: German Society of Anaesthesiology and Intensive Care Medicine (DGAI).
authors.forename: Hartmut
authors.initials: H
authors.lastname: Buerkle
authors.affiliation: German Society of Gynecology & Obstetrics (DGGG).
authors.forename: Peter
authors.initials: P
authors.lastname: Dall
authors.affiliation: German Society of Neonatology and Pediatric Intensive Care (GNPI).
authors.forename: Sueha
authors.initials: S
authors.lastname: Demirakca
authors.affiliation: German Society of Geriatrics (DGG).
authors.forename: Rahel
authors.initials: R
authors.lastname: Eckardt
authors.affiliation: German Society of Anaesthesiology and Intensive Care Medicine (DGAI).
authors.forename: Verena
authors.initials: V
authors.lastname: Eggers
authors.affiliation: German Society for Thoracic and Cardiovascular Surgery (DGTHG).
authors.forename: Ingolf
authors.initials: I
authors.lastname: Eichler
authors.affiliation: German Sleep Society (DGSM).
authors.forename: Ingo
authors.initials: I
authors.lastname: Fietze
authors.affiliation: German Society of Surgery (DGCH).
authors.forename: Stephan
authors.initials: S
authors.lastname: Freys
authors.affiliation: German Association for Physiotherapy (ZVK).
authors.forename: Andreas
authors.initials: A
authors.lastname: Fründ
authors.affiliation: German Society of Neonatology and Pediatric Intensive Care (GNPI).
authors.forename: Lars
authors.initials: L
authors.lastname: Garten
authors.affiliation: German Society for Thoracic and Cardiovascular Surgery (DGTHG).
authors.forename: Bernhard
authors.initials: B
authors.lastname: Gohrbandt
authors.affiliation: German Society of Neonatology and Pediatric Intensive Care (GNPI).
authors.forename: Irene
authors.initials: I
authors.lastname: Harth
authors.affiliation: German Society of Surgery (DGCH).
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hartl
authors.affiliation: German Society of Geriatrics (DGG).
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Heppner
authors.affiliation: German Society of Anaesthesiology and Intensive Care Medicine (DGAI).
authors.forename: Johannes
authors.initials: J
authors.lastname: Horter
authors.affiliation: German Society of Neonatology and Pediatric Intensive Care (GNPI).
authors.forename: Ralf
authors.initials: R
authors.lastname: Huth
authors.affiliation: German Society of Internal Medicine Intensive Care (DGIIN).
authors.forename: Uwe
authors.initials: U
authors.lastname: Janssens
authors.affiliation: German Society of Neurosurgery (DGNC).
authors.forename: Christine
authors.initials: C
authors.lastname: Jungk
authors.affiliation: German Society of Midwifery Science (DGHWi).
authors.forename: Kristin Maria
authors.initials: KM
authors.lastname: Kaeuper
authors.affiliation: German Society of Anaesthesiology and Intensive Care Medicine (DGAI).
authors.forename: Paul
authors.initials: P
authors.lastname: Kessler
authors.affiliation: German Society of Anaesthesiology and Intensive Care Medicine (DGAI).
authors.forename: Stefan
authors.initials: S
authors.lastname: Kleinschmidt
authors.affiliation: German Society of Haematology and Oncology (DGHO).
authors.forename: Matthias
authors.initials: M
authors.lastname: Kochanek
authors.affiliation: German Society of Neonatology and Pediatric Intensive Care (GNPI).
authors.forename: Matthias
authors.initials: M
authors.lastname: Kumpf
authors.affiliation: German Society of Anaesthesiology and Intensive Care Medicine (DGAI).
authors.forename: Andreas
authors.initials: A
authors.lastname: Meiser
authors.affiliation: German Society of Anaesthesiology and Intensive Care Medicine (DGAI).
authors.forename: Anika
authors.initials: A
authors.lastname: Mueller
authors.affiliation: German Sleep Society (DGSM).
authors.forename: Maritta
authors.initials: M
authors.lastname: Orth
authors.affiliation: German Society of Anaesthesiology and Intensive Care Medicine (DGAI).
authors.forename: Christian
authors.initials: C
authors.lastname: Putensen
authors.affiliation: German Society of Neonatology and Pediatric Intensive Care (GNPI).
authors.forename: Bernd
authors.initials: B
authors.lastname: Roth
authors.affiliation: German Pain Society (DGSS).
authors.forename: Michael
authors.initials: M
authors.lastname: Schaefer
authors.affiliation: German Society of Midwifery Science (DGHWi).
authors.forename: Rainhild
authors.initials: R
authors.lastname: Schaefers
authors.affiliation: German Society of Haematology and Oncology (DGHO).
authors.forename: Peter
authors.initials: P
authors.lastname: Schellongowski
authors.affiliation: German Society of Neonatology and Pediatric Intensive Care (GNPI).
authors.forename: Monika
authors.initials: M
authors.lastname: Schindler
authors.affiliation: German Society for Specialised Nursing and Allied Health Professions (DGF).
authors.forename: Reinhard
authors.initials: R
authors.lastname: Schmitt
authors.affiliation: German Society of Anaesthesiology and Intensive Care Medicine (DGAI).
authors.forename: Jens
authors.initials: J
authors.lastname: Scholz
authors.affiliation: German Association for Psychiatry, Psychotherapy and Psychosomatics (DGPPN).
authors.forename: Stefan
authors.initials: S
authors.lastname: Schroeder
authors.affiliation: German Society for Specialised Nursing and Allied Health Professions (DGF).
authors.forename: Gerhard
authors.initials: G
authors.lastname: Schwarzmann
authors.affiliation: German Society of Anaesthesiology and Intensive Care Medicine (DGAI).
authors.forename: Claudia
authors.initials: C
authors.lastname: Spies
authors.affiliation: German Society of Neurology (DGN).
authors.forename: Robert
authors.initials: R
authors.lastname: Stingele
authors.affiliation: German Society of Anaesthesiology and Intensive Care Medicine (DGAI).
authors.forename: Peter
authors.initials: P
authors.lastname: Tonner
authors.affiliation: German Society of Anaesthesiology and Intensive Care Medicine (DGAI).
authors.forename: Uwe
authors.initials: U
authors.lastname: Trieschmann
authors.affiliation: German Society of Anaesthesiology and Intensive Care Medicine (DGAI).
authors.forename: Michael
authors.initials: M
authors.lastname: Tryba
authors.affiliation: German Society of Anaesthesiology and Intensive Care Medicine (DGAI).
authors.forename: Frank
authors.initials: F
authors.lastname: Wappler
authors.affiliation: German Interdisciplinary Association for Intensive Care and Emergency Medicine (DIVI).
authors.forename: Christian
authors.initials: C
authors.lastname: Waydhas
authors.affiliation: German Society of Anaesthesiology and Intensive Care Medicine (DGAI).
authors.forename: Bjoern
authors.initials: B
authors.lastname: Weiss
authors.affiliation: German Society of Neonatology and Pediatric Intensive Care (GNPI).
authors.forename: Guido
authors.initials: G
authors.lastname: Weisshaar
mesh_terms: D000698:Analgesia / Q000592:standards*; D001007:Anxiety / Q000175:diagnosis / Q000188:drug therapy; D016292:Procedural Sedation / Q000592:standards*; D032921:Consensus; D003422:Critical Care / Q000592:standards*; D054810:Deep Sedation / Q000592:standards*; D003693:Delirium / Q000175:diagnosis / Q000188:drug therapy* / Q000628:therapy; D019317:Evidence-Based Medicine; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D012890:Sleep; D013315:Stress, Psychological / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D006993:Hypnotics and Sedatives
keywords: Germany; analgesia; anxiety; critical care; delirium; evidence; guideline; intensive care; monitoring; sedation; sleep; stress; treatment