title: Impact of EGFR mutations and KRAS amino acid substitution on the response to radiotherapy for brain metastasis of non-small-cell lung cancer.
abstract: BACKGROUND
  Our study aimed to evaluate response rate (RR) to brain metastasis radiotherapy (RT), depending on the genomic status of non-small-cell lung cancer.
  
  
  METHODS
  We retrospectively reviewed 1971 non-small-cell lung cancer files of patients with EGFR and KRAS testing and focused on 157 patients who had undergone RT for brain metastasis.
  
  
  RESULTS
  A total of 16 patients (10.2%) harbored EGFR mutations (mEGFR) and 45 patients (28.7%) KRAS (mKRAS). In univariate analysis, RR was significantly higher for mEGFR compared with wild-type EGFR/KRAS (odds ratio [OR]: 4.96; p = 0.05) or mKRAS (OR: 1.81; p = 0.03). In multivariate analysis, KRAS G12V or G12C status was associated with both poor RR (OR: 0.1; p < 0.0001) and overall survival (OR: 3.41; p < 0.0001).
  
  
  CONCLUSIONS
  mEGFR are associated with higher RR to brain RT than wild-type EGFR/RAS or mKRAS.
authors.affiliation: Thoracic Surgery Department, Strasbourg University Hospital, France.|Research Unit EA 3430 & Translational Medicine Federation, Strasbourg University, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Renaud
authors.affiliation: Statistical Department, Strasbourg University Hospital, France.
authors.forename: Mickaël
authors.initials: M
authors.lastname: Schaeffer
authors.affiliation: Department of Biochemistry & Molecular Biology, Oncobiology laboratory, Regional Institute of Cancer, Strasbourg University Hospital, France.
authors.forename: Anne-Claire
authors.initials: AC
authors.lastname: Voegeli
authors.affiliation: Department of Biochemistry & Molecular Biology, Oncobiology laboratory, Regional Institute of Cancer, Strasbourg University Hospital, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Legrain
authors.affiliation: Department of Biochemistry & Molecular Biology, Oncobiology laboratory, Regional Institute of Cancer, Strasbourg University Hospital, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Guérin
authors.affiliation: Statistical Department, Strasbourg University Hospital, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Meyer
authors.affiliation: Chest Department, Strasbourg University Hospital, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Mennecier
authors.affiliation: Chest Department, Strasbourg University Hospital, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Quoix
authors.affiliation: Thoracic Surgery Department, Strasbourg University Hospital, France.
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Falcoz
authors.affiliation: Research Unit EA 3430 & Translational Medicine Federation, Strasbourg University, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Guénot
authors.affiliation: Thoracic Surgery Department, Strasbourg University Hospital, France.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Massard
authors.affiliation: Department of Radiotherapy, Centre Paul Strauss, Strasbourg, France.
authors.forename: Georges
authors.initials: G
authors.lastname: Noël
authors.affiliation: Research Unit EA 3430 & Translational Medicine Federation, Strasbourg University, France.|Department of Biochemistry & Molecular Biology, Oncobiology laboratory, Regional Institute of Cancer, Strasbourg University Hospital, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Beau-Faller
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019943:Amino Acid Substitution / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy*; D018572:Disease-Free Survival; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D011836:Radiation Tolerance / Q000235:genetics
chemical_list: C117307:KRAS protein, human; C512478:EGFR protein, human; D066246:ErbB Receptors; D016283:Proto-Oncogene Proteins p21(ras)
keywords: EGFR; G12C; G12V; KRAS; brain metastases; non-small-cell lung cancer; radiotherapy