title: Effect of Diet and Exercise on the Peripheral Immune System in Young Balb/c Mice.
abstract: Although diet and exercise clearly have an influence on immune function, studies are scarce on the effect caused by exercise and the consumption of a carbohydrate-rich or fat-rich diet on the peripheral immune system. The aim of the present study was to evaluate the effect of exercise and the two aforementioned unbalanced diets on young Balb/c mice, especially in relation to BMI, the level of glucose, and the percentage of lymphocyte subpopulations in peripheral blood. The changes found were then related to the synthesis of leptin and adiponectin as well as the production of oxidative stress. The increase in BMI found with the carbohydrate-rich and fat-rich diets showed correlation with the levels of leptin and adiponectin. An increase in leptin and a decrease in adiponectin directly correlated with an increase in total lymphocytes and CD4+ cells and with a decrease in B cells. The increase in leptin also correlated with an increase in CD8+ cells. Glycemia and oxidative stress increased with the two unbalanced diets, negatively affecting the proliferation of total lymphocytes and the percentage of B cells, apparently by causing alterations in proteins through carbonylation. These alterations caused by an unbalanced diet were not modified by moderate exercise.
authors.affiliation: Sección de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340 Ciudad de Mexico, DF, Mexico ; Centro de Investigación y Estudios Avanzados en Ciencias de la Salud (CIEACS), Facultad de Medicina, Universidad Autónoma del Estado de México, Paseo Tollocan, Esquina Jesús Carranza, Colonia Moderna de la Cruz, 50180 Toluca, MEX, Mexico.
authors.forename: B E
authors.initials: BE
authors.lastname: Martínez-Carrillo
authors.affiliation: Sección de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340 Ciudad de Mexico, DF, Mexico ; Coordinación de Morfología, Departamento de Formación Básica Disciplinaria, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340 Ciudad de Mexico, DF, Mexico.
authors.forename: R A
authors.initials: RA
authors.lastname: Jarillo-Luna
authors.affiliation: Sección de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340 Ciudad de Mexico, DF, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: Campos-Rodríguez
authors.affiliation: Centro de Investigación y Estudios Avanzados en Ciencias de la Salud (CIEACS), Facultad de Medicina, Universidad Autónoma del Estado de México, Paseo Tollocan, Esquina Jesús Carranza, Colonia Moderna de la Cruz, 50180 Toluca, MEX, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: Valdés-Ramos
authors.affiliation: Departamento de Microbiología, UBIPRO, FES-Iztacala, UNAM, Avenida de los Barrios s/n, 54090 Tlalnepantla, MEX, Mexico.
authors.forename: V
authors.initials: V
authors.lastname: Rivera-Aguilar
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000276:immunology*; D015992:Body Mass Index; D016207:Cytokines / Q000276:immunology; D004032:Diet / Q000379:methods*; D004435:Eating / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000276:immunology*; D010805:Physical Conditioning, Animal / Q000379:methods
chemical_list: D001786:Blood Glucose; D016207:Cytokines