title: Neuropsychiatric Features in Primary Mitochondrial Disease.
abstract: Mitochondrial diseases are a clinically heterogeneous group of disorders that ultimately result from dysfunction of the mitochondrial respiratory chain. There is some evidence to suggest that mitochondrial dysfunction plays a role in neuropsychiatric illness; however, the data are inconclusive. This article summarizes the available literature published in the area of neuropsychiatric manifestations in both children and adults with primary mitochondrial disease, with a focus on autism spectrum disorder in children and mood disorders and schizophrenia in adults.
authors.affiliation: Department of Neurosciences, University of California, San Diego (UCSD), 9500 Gilman Drive #0935, La Jolla, CA 92093-0935, USA.
authors.forename: Samantha E
authors.initials: SE
authors.lastname: Marin
authors.affiliation: Department of Neurology, Seattle Children's Hospital, University of Washington, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA; Department of Pediatrics, Seattle Children's Hospital, University of Washington, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA. Electronic address: russ.saneto@seattlechildrens.org.
authors.forename: Russell P
authors.initials: RP
authors.lastname: Saneto
mesh_terms: D000328:Adult; D000067877:Autism Spectrum Disorder / Q000209:etiology* / Q000523:psychology; D002648:Child; D006801:Humans; D001523:Mental Disorders / Q000209:etiology* / Q000523:psychology; D028361:Mitochondrial Diseases / Q000150:complications* / Q000523:psychology
keywords: Anxiety; Autism; Behavioral; Bipolar disorder; Depression; Mitochondrial; Neuropsychiatric; Schizophrenia