title: High-dose chemotherapy combined with autologous peripheral blood stem cell transplantation in children with advanced malignant solid tumors: A retrospective analysis of 38 cases.
abstract: The aim of the present study was to assess the toxicity and efficacy of autologous peripheral blood stem cell (APBSC) transplantation in children with advanced malignant solid tumors. The outcomes of 38 children with advanced malignant solid tumor, who were treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation in Beijing Tongren Hospital (Capital Medical University, Beijing, China) between September 2005 and November 2011, were retrospectively analyzed. The effects of treatment were evaluated according to the standard Bearman's criteria. The mean count of collected mononuclear cells and the cluster of differentiation 34+cell count from 38 patients was 5.6±2.2×108/kg and 3.8±2.6×106/kg, respectively. From these 38 patients, the number of stem cells collected from 31 cases (81.6%) accorded with the transplantation standards. Three and 14 days after pretreatment in these 38 cases, there were 19 cases of grade I, 11 cases of grade II, five cases of grade III and three cases of grade IV (one case succumbed) adverse reaction. Following the treatment (23-40 days after pretreatment, during organ injury recovery), 37 cases obtained bone marrow reconstitution with a mean time of 12.3±3.1 days after APBSC reinfusion. The median survival time of the 37 patients was 49 months, and the survival rate at one, three and five years post-treatment was 91.9, 68.2 and 36.6%, respectively.
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China.
authors.forename: Wei-Ling
authors.initials: WL
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Y I
authors.initials: YI
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China.
authors.forename: Tian
authors.initials: T
authors.lastname: Zhi
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China.
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Huang
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China.
authors.forename: Yi-Zhuo
authors.initials: YZ
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Hong
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China.
authors.forename: Ai-Ping
authors.initials: AP
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China.
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Hu
keywords: autologous; children; peripheral blood stem cell; solid tumor; transplantation