title: Clinical evaluation of the Heart Check system, a new quantitative measurement of fresh capillary BNP.
abstract: OBJECTIVE
  We have evaluated here the clinical and analytical performance of the Alere™ Heart Check (AHC) test, a rapid point-of-care immunoassay designed for the measurement of BNP from fresh capillary whole blood.
  
  
  METHODS
  One-hundred-and-sixty-three patients with stable chronic heart failure followed at the cardiac rehabilitation were submitted to simultaneous capillary (AHC) and plasma (Abbott architect system) BNP measurements.
  
  
  RESULTS
  Both methods showed a good correlation, although the values diverged when BNP was higher than 2000 pg/ml. Despite a relatively poor precision of AHC, however, both methods showed the same performances to assess patients' dyspnea and equivalent sensitivity, specificity, negative and positive predicting values.
  
  
  CONCLUSIONS
  AHC BNP test is a good POC for the management of heart failure despite a relatively poor precision.
authors.affiliation: Inserm UMR-S 942, Paris, France.|Department of Cardiology, Lariboisière Hospital, Paris, France.
authors.forename: Astrid
authors.initials: A
authors.lastname: Monfort
authors.affiliation: Biossip Analytical Platform, Center for Biological Resources BB-0033-00064, Lariboisière Hospital, Paris, France.
authors.forename: Kelly
authors.initials: K
authors.lastname: Da Silva
authors.affiliation: Inserm UMR-S 942, Paris, France.|DHU FIRE, Paris-Diderot University, Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Vodovar
authors.affiliation: Inserm UMR-S 942, Paris, France.|Department of Anesthesiology & Intensive Care, Lariboisière Hospital, Paris, France.|DHU Neurovasc, Paris-Diderot University, Paris, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Gayat
authors.affiliation: Inserm UMR-S 942, Paris, France.|Department of Cardiology, Lariboisière Hospital, Paris, France.|DHU FIRE, Paris-Diderot University, Paris, France.|Paris Diderot University, Sorbonne Paris Cité, Paris, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Cohen-Solal
authors.affiliation: Inserm UMR-S 942, Paris, France.|Biossip Analytical Platform, Center for Biological Resources BB-0033-00064, Lariboisière Hospital, Paris, France.|DHU Neurovasc, Paris-Diderot University, Paris, France.|Department of Biochemistry, Lariboisière Hospital, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Manivet
mesh_terms: D000368:Aged; D002196:Capillaries / Q000378:metabolism*; D005240:Feasibility Studies; D005260:Female; D006333:Heart Failure / Q000097:blood; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D019095:Point-of-Care Systems; D012372:ROC Curve; D011933:Reagent Kits, Diagnostic; D012015:Reference Standards
chemical_list: D011933:Reagent Kits, Diagnostic; D020097:Natriuretic Peptide, Brain
keywords: BNP; capillary whole blood; chronic heart failure; correlation; evaluation; immunoassay; patient dyspnea assessment; point of care; reference method; sensitivity; specificity