title: An analysis of cochlear response harmonics: Contribution of neural excitation.
abstract: In this report an analysis of cochlear response harmonics is developed to derive a mathematical function to estimate the gross mechanics involved in the in vivo transfer of acoustic sound into neural excitation (f(Tr)). In a simulation it is shown that the harmonic distortion from a nonlinear system can be used to estimate the nonlinearity, supporting the next phase of the experiment: Applying the harmonic analysis to physiologic measurements to derive estimates of the unknown, in vivo f(Tr). From gerbil ears, estimates of f(Tr) were derived from cochlear response measurements made with an electrode at the round window niche from 85 Hz tone bursts. Estimates of f(Tr) before and after inducing auditory neuropathy-loss of auditory nerve responses with preserved hair cell responses from neurotoxic treatment with ouabain-showed that the neural excitation from low-frequency tones contributes to the magnitude of f(Tr) but not the sigmoidal, saturating, nonlinear morphology.
authors.affiliation: Department of Hearing and Speech, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Chertoff
authors.affiliation: Department of Hearing and Speech, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Kamerer
authors.affiliation: Department of Hearing and Speech, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
authors.forename: M
authors.initials: M
authors.lastname: Peppi
authors.affiliation: Department of Otolaryngology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Lichtenhan
mesh_terms: D000162:Acoustics; D000200:Action Potentials; D000818:Animals; D001306:Auditory Pathways / Q000502:physiology; D003051:Cochlea / Q000502:physiology*; D003056:Cochlear Nerve / Q000187:drug effects / Q000502:physiology; D003198:Computer Simulation; D005260:Female; D005849:Gerbillinae / Q000502:physiology; D006198:Hair Cells, Auditory / Q000502:physiology; D040542:Mechanotransduction, Cellular; D008959:Models, Neurological; D009498:Neurotoxins / Q000633:toxicity; D017711:Nonlinear Dynamics; D010042:Ouabain / Q000633:toxicity
chemical_list: D009498:Neurotoxins; D010042:Ouabain