title: Octacalcium phosphate collagen composite facilitates bone regeneration of large mandibular bone defect in humans.
abstract: Recently it was reported that the implantation of octacalcium phosphate (OCP) and collagen composite (OCP-collagen) was effective at promoting bone healing in small bone defects after cystectomy in humans. In addition, OCP-collagen promoted bone regeneration in a critical-sized bone defect of a rodent or canine model. In this study, OCP-collagen was implanted into a human mandibular bone defect with a longer axis of approximately 40 mm, which was diagnosed as a residual cyst with apical periodontitis. The amount of OCP-collagen implanted was about five times greater than the amounts implanted in previous clinical cases. Postoperative wound healing was satisfactory and no infection or allergic reactions occurred. The OCP-collagen-treated lesion was gradually filled with radio-opaque figures, and the alveolar region occupied the whole of the bone defect 12 months after implantation. This study suggests that OCP-collagen could be a useful bone substitute material for repairing large bone defects in humans that might not heal spontaneously. Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, Sendai, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kawai
authors.affiliation: Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Suzuki
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, Sendai, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Matsui
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, Sendai, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tanuma
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, Sendai, Japan.
authors.forename: Tetsu
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Bone Regenerative Engineering Laboratory, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Kamakura
mesh_terms: D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000008:administration & dosage*; D002130:Calcium Phosphates / Q000008:administration & dosage*; D003094:Collagen / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008338:Mandibular Injuries / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism; D013997:Time Factors
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C022045:octacalcium phosphate; D003094:Collagen
keywords: bone defect; bone regeneration; bone substitute material; octacalcium phosphate collagen composite (OCP-collagen)