title: Molecular Insights into the Pathogenesis of IgA Nephropathy.
abstract: Immunoglobulin IgA nephropathy (IgAN) is the leading form of primary glomerulonephritis associated with end-stage renal failure, requiring either dialysis or renal transplantation. Microscopic hematuria and proteinuria are the most common presentations, and mesangial cell proliferation with IgA deposition are found in renal biopsies. There is growing evidence that IgAN is an immune complex (IC)-mediated disease. To date, three key molecules have been implicated in IC formation, correlating with disease progression/recurrence after transplantation: galactose-deficient IgA1 (Gd-IgA1), IgG anti-Gd-IgA1 antibodies, and soluble CD89 (an Fc receptor for IgA). This review examines recent data on the role of these molecular players in IgAN. Understanding these factors is essential because such knowledge could lead to improved strategies for the future management of patients with IgAN.
authors.affiliation: Department of Nephrology Transplantation and Emergency, Assistance Publique-Hôpitaux de Paris, Tenon Hospital, Paris, France; University Pierre et Marie Curie Paris 6, Paris, France. Electronic address: thomas.robert@tnn.aphp.fr.
authors.forename: Thomas
authors.initials: T
authors.lastname: Robert
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1149, Center for Research on Inflammation, Centre National de la Recherche Scientifique (CNRS) Equipe de Recherche Labellisée 8252, Paris, France; University Paris Diderot, Paris 7, Inflamex Laboratory of Excellence, Site Xavier Bichat, Paris, France.
authors.forename: Laureline
authors.initials: L
authors.lastname: Berthelot
authors.affiliation: Department of Nephrology Transplantation and Emergency, Assistance Publique-Hôpitaux de Paris, Tenon Hospital, Paris, France; University Pierre et Marie Curie Paris 6, Paris, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Cambier
authors.affiliation: Department of Nephrology Transplantation and Emergency, Assistance Publique-Hôpitaux de Paris, Tenon Hospital, Paris, France; University Pierre et Marie Curie Paris 6, Paris, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Rondeau
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1149, Center for Research on Inflammation, Centre National de la Recherche Scientifique (CNRS) Equipe de Recherche Labellisée 8252, Paris, France; University Paris Diderot, Paris 7, Inflamex Laboratory of Excellence, Site Xavier Bichat, Paris, France; Department of Immunology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Fire, France. Electronic address: renato.monteiro@inserm.fr.
authors.forename: Renato C
authors.initials: RC
authors.lastname: Monteiro
mesh_terms: D000936:Antigen-Antibody Complex / Q000378:metabolism; D005922:Glomerulonephritis, IGA / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007674:Kidney Diseases / Q000276:immunology / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D050527:Mesangial Cells / Q000473:pathology
chemical_list: D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A