title: Targeted Delivery of Bleomycin: A Comprehensive Anticancer Review.
abstract: Despite being one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers, the clinical applications of bleomycins (BLMs) have been limited due to their poor drug delivery abilities, and the side effect of causing lung fibrosis. With the increased therapeutics and the reduction of side effects, research and development of targeted drug delivery systems (TDDS) with BLMs have become essential for the expansive clinical usage of BLM-based therapeutics. This review summarizes the recent developments of various TDDS for BLMs, including techniques such as photochemical internalization, ultrasound, and micelle, liposome, and nanoparticle formation. The advantages and disadvantages for each delivery approach are outlined, along with the specific challenges associated with each delivery system.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Yu
authors.forename: Bo
authors.initials: B
authors.lastname: Yan
authors.forename: Liqian
authors.initials: L
authors.lastname: Gao
authors.forename: Chenbo
authors.initials: C
authors.lastname: Dong
authors.forename: Jian
authors.initials: J
authors.lastname: Zhong
authors.forename: Mathew
authors.initials: M
authors.lastname: D Ortenzio
authors.forename: Brandon
authors.initials: B
authors.lastname: Nguyen
authors.forename: Su
authors.initials: S
authors.lastname: Seong Lee
authors.affiliation: Ministry of Education Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China. xlhu@scnu.edu.cn.
authors.forename: Xianglong
authors.initials: X
authors.lastname: Hu
authors.affiliation: The State Key Laboratory of Refractories and Metallurgy, Wuhan University of Science and Technology, Wuhan 430081, China. feng_liang@whu.edu.cn.
authors.forename: Feng
authors.initials: F
authors.lastname: Liang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry; D008823:Micelles; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes; D008823:Micelles; D001761:Bleomycin