title: HLA-DRB1 gene polymorphisms and its associations with rheumatoid arthritis in Chinese Han women of Shaanxi province, northwest of China.
abstract: Rheumatoid arthritis (RA) is a common chronic autoimmune disease characterized by symmetric polyarthritis. This study was designed to investigate the associations between HLA-DRB1 gene polymorphisms and RA in the Chinese Han population of Shaanxi province, northwest of China. In total, we identified 31 high-resolution HLA-DRB1 alleles in 109 patients with RA. Compared with the controls, the AF of HLA-DRB1*04:05 (P = 0.000, Pc = 0.007, OR = 3.462, 95%CI: 1.749-6.852) was significantly higher in patients with RA. In addition, the patients with RA had higher allele frequency (AF) of the HLA-DRB1*04:03 (P = 0.030, Pc = NS, OR = 4.737, 95%CI: 1.012-22.180); DRB1*04:06 (P = 0.018, Pc = NS, OR = 5.288, 95%CI: 1.145-24.422) and the shared epitope (SE) alleles (P = 0.004, Pc = NS, OR = 2.166, 95%CI: 1.279-3.667), respectively. Moreover, positive possibilities of RF and anti-CCP were significant higher in SE-positive patients compared to SR-negative patients (OR = 4.787, 95%CI: 1.101-20.824; OR = 3.775, 95%CI: 1.106-12.876, respectively). Our results indicated that HLA-DRB1*04:05, *04:03, *04:06 and SE alleles might be susceptibility allele for RA in Chinese Han population of Shaanxi province, northwest of China.
authors.affiliation: Second Department of Rheumatology, The Fifth Hospital of Xi'an City, Xi'an, China.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Gynecology, Tumor Hospital of Shaanxi Province, Xi'an, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Gynecology, Tumor Hospital of Shaanxi Province, Xi'an, China.
authors.forename: G-Q
authors.initials: GQ
authors.lastname: Wang
authors.affiliation: Second Department of Rheumatology, The Fifth Hospital of Xi'an City, Xi'an, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Quan
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000473:pathology; D002681:China; D000939:Epitopes / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000939:Epitopes; D059811:HLA-DRB1 Chains