title: Pleurectomy/decortication and hyperthermic intrapleural chemotherapy for malignant pleural mesothelioma: initial experience.
abstract: Cytoreductive surgery and hyperthermic intraoperative intrapleural chemotherapy (HITHOC) are a known option for malignant pleural mesothelioma (MPM). This prospective study was started to prove that pleurectomy/decortication and HITHOC could be successfully performed in a low volume center. Criteria of inclusion were a proven diagnosis of MPM, early-stage disease and good performance status. Six consecutive patients were enrolled. After pleurectomy/decortication, intrapleural cisplatin was administered for 60 min at 42.5 °C. Wedge resections and diaphragmatic reconstruction were added in two and one patient, respectively. Morbidity was 16.6%. Mortality was nil. Hospital stay was 7.8 days. Mean survival was 21.5 months (range: 6-30). This small experience confirms that pleurectomy/decortication and HITHOC are a good therapeutic option in the multimodality treatment of MPM. A randomized controlled trial is necessary.
authors.affiliation: Section of Thoracic Surgery, Department of General Surgery & Medical Specialities, University of Catania, Policlinico Hospital, Catania, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Migliore
authors.affiliation: Section of Thoracic Surgery, Department of General Surgery & Medical Specialities, University of Catania, Policlinico Hospital, Catania, Italy.
authors.forename: Damiano
authors.initials: D
authors.lastname: Calvo
authors.affiliation: Section of Thoracic Surgery, Department of General Surgery & Medical Specialities, University of Catania, Policlinico Hospital, Catania, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Criscione
authors.affiliation: Radiodiagnostic & Radiotherapy Unit, Policlinico Hospital, Catania, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Palmucci
authors.affiliation: Radiodiagnostic & Radiotherapy Unit, Policlinico Hospital, Catania, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fuccio Sanzà
authors.affiliation: Pathology Unit, Policlinico Hospital, Catania, Italy.
authors.forename: Rosario
authors.initials: R
authors.lastname: Caltabiano
authors.affiliation: Radiodiagnostic & Radiotherapy Unit, Policlinico Hospital, Catania, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Spatola
authors.affiliation: Radiodiagnostic & Radiotherapy Unit, Policlinico Hospital, Catania, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Privitera
authors.affiliation: Oncology Unit, Policlinico Hospital, Catania, Italy.
authors.forename: Marco Maria
authors.initials: MM
authors.lastname: Aiello
authors.affiliation: Oncology Unit, Policlinico Hospital, Catania, Italy.
authors.forename: Hector Soto
authors.initials: HS
authors.lastname: Parra
authors.affiliation: Pneumology Unit, Policlinico Hospital, Catania, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Ciancio
authors.affiliation: Pneumology Unit, Policlinico Hospital, Catania, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Maria
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D011446:Prospective Studies; D019616:Thoracic Surgical Procedures / Q000379:methods
chemical_list: D002945:Cisplatin
keywords: HITHOC; VATS; chemotherapy; cisplatin; cytoreductive surgery; hyperthermic perfusion; mesothelioma; multimodality treatment