title: The current landscape of the mesenchymal stromal cell secretome: A new paradigm for cell-free regeneration.
abstract: The unique properties of mesenchymal stromal/stem cells (MSCs) to self-renew and their multipotentiality have rendered them attractive to researchers and clinicians. In addition to the differentiation potential, the broad repertoire of secreted trophic factors (cytokines) exhibiting diverse functions such as immunomodulation, anti-inflammatory activity, angiogenesis and anti-apoptotic, commonly referred to as the MSC secretome, has gained immense attention in the past few years. There is enough evidence to show that the one important pathway by which MSCs participate in tissue repair and regeneration is through its secretome. Concurrently, a large body of MSC research has focused on characterization of the MSC secretome; this includes both soluble factors and factors released in extracellular vesicles, for example, exosomes and microvesicles. This review provides an overview of our current understanding of the MSC secretome with respect to their potential clinical applications.
authors.affiliation: Department of Marine Biotechnology, AMET University, Kanathur, Chennai, India; Genes & Life Health Care Pvt. Ltd, Punjagutta, Hyderabad, India.
authors.forename: Vijay Bhaskar Reddy
authors.initials: VB
authors.lastname: Konala
authors.affiliation: School of Regenerative Medicine, Manipal University, Bangalore, India.
authors.forename: Murali Krishna
authors.initials: MK
authors.lastname: Mamidi
authors.affiliation: School of Regenerative Medicine, Manipal University, Bangalore, India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Bhonde
authors.affiliation: Department of Surgery, Taylor's University School of Medicine, Sungai Buloh Hospital, Selangor, Malaysia.
authors.forename: Anjan Kumar
authors.initials: AK
authors.lastname: Das
authors.affiliation: Department of Biochemistry, Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi, USA.
authors.forename: Radhika
authors.initials: R
authors.lastname: Pochampally
authors.affiliation: School of Regenerative Medicine, Manipal University, Bangalore, India. Electronic address: rajarshi.pal@manipal.edu.
authors.forename: Rajarshi
authors.initials: R
authors.lastname: Pal
mesh_terms: D002465:Cell Movement; D055354:Exosomes / Q000378:metabolism; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D012038:Regeneration; D055153:Stem Cell Niche; D057170:Translational Research, Biomedical
keywords: cell therapy; exosomes; mesenchymal stromal cells; regeneration; secretome