title: Energy Adaptations Persist 2 Years After Sleeve Gastrectomy and Gastric Bypass.
abstract: Non-surgical weight loss induces a greater than expected decrease in energy expenditure, a phenomenon known as 'metabolic adaptation'. The effects of different bariatric surgery procedures on metabolic adaptation are not yet known and may partially contribute to weight loss success. We compared resting energy expenditure (REE) in 35 subjects (nine males; age = 46 ± 11 years; BMI = 42.1 ± 6.5 kg/m(2)) undergoing gastric band, sleeve gastrectomy or Roux-en-Y gastric bypass (RYGB) up to 2 years after surgery. We found a greater than expected reduction of 130-300 kcal/day at 6 weeks after sleeve and bypass surgery which was not explained by changes in body composition; this change was not seen in the band group. The suppression in REE after sleeve and RYGB remained up to 2 years, even after weight loss had plateaued. Our findings suggest that energy adaptation is not a contributing mechanism to medium-term weight maintenance after sleeve and RYGB bariatric surgeries.
authors.affiliation: The Charles Perkins Centre and School of Biological Sciences, University of Sydney, Sydney, Australia. charmaine.tam@sydney.edu.au.
authors.forename: Charmaine S
authors.initials: CS
authors.lastname: Tam
authors.affiliation: Upper Gastrointestinal Unit, Department of Surgery, St George Private Hospital, Suite 3, Level 5, 1 South St, Kogarah, Australia. georgiarigas@hotmail.com.
authors.forename: Georgia
authors.initials: G
authors.lastname: Rigas
authors.affiliation: Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia. leonie.heilbronn@adelaide.edu.au.
authors.forename: Leonie K
authors.initials: LK
authors.lastname: Heilbronn
authors.affiliation: Upper Gastrointestinal Unit, Department of Surgery, St George Private Hospital, Suite 3, Level 5, 1 South St, Kogarah, Australia. taniam@uppergisurgery.com.au.
authors.forename: Tania
authors.initials: T
authors.lastname: Matisan
authors.affiliation: Smart Foods Centre, School of Medicine, University of Wollongong, Wollongong, NSW, Australia. yasmine@uow.edu.au.
authors.forename: Yasmine
authors.initials: Y
authors.lastname: Probst
authors.affiliation: Upper Gastrointestinal Unit, Department of Surgery, St George Private Hospital, Suite 3, Level 5, 1 South St, Kogarah, Australia. michaelt@upperisugery.com.au.
authors.forename: Michael
authors.initials: M
authors.lastname: Talbot
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D050110:Bariatric Surgery / Q000379:methods*; D001481:Basal Metabolism / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005743:Gastrectomy; D015390:Gastric Bypass; D015391:Gastroplasty; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology* / Q000601:surgery*; D015431:Weight Loss / Q000502:physiology
keywords: Energy expenditure; Metabolic adaptation; Resting metabolic rate