title: The manufacture of blood plasma products in Scotland: a brief history.
abstract: A number of essential clinical products are derived from human blood plasma, including immunoglobulin products for the treatment of infections and disorders of immunity; albumin for protein and fluid replacement and coagulation factors for the treatment of haemophilia and other disorders of haemostasis. For many years, these protein pharmaceuticals were manufactured by the Scottish National Blood Transfusion Service (SNBTS) at its Scottish Protein Fractionation Centre (PFC) in Edinburgh, a contribution which ended with the closure of the PFC in 2008. The origins and development of plasma fractionation in Scotland are summarised in this article, as well as issues which contributed to the closure of the PFC.
authors.affiliation: Formerly Development Manager, SNBTS Protein Fractionation Centre, UK peterrfoster@btinternet.com.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Foster
mesh_terms: D002458:Cell Fractionation / Q000266:history* / Q000379:methods; D003132:Commerce / Q000266:history / Q000379:methods; D005169:Factor VIII / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007136:Immunoglobulins / Q000266:history*; D010949:Plasma; D012606:Scotland
chemical_list: D007136:Immunoglobulins; D005169:Factor VIII
keywords: Plasma fractionation; Protein Fractionation Centre; blood products; protein pharmaceuticals; transfusion medicine