title: Relationships between the duration of illness and the current status of diabetes in elderly patients with type 2 diabetes mellitus.
abstract: OBJECTIVE
  The aim of the present study was to clarify the relationships between the duration of diabetes and the current statuses of diabetes in elderly (aged ≥65 years) patients with type 2 diabetes.
  
  
  METHODS
  Clinical characteristics were cross-sectionally examined in 1436 patients (684 elderly and 752 non-elderly) with type 2 diabetes.
  
  
  RESULTS
  As the duration of diabetes increased, the patients' age, frequency of receiving insulin therapy and glycated hemoglobin value increased in both the elderly and non-elderly groups, whereas the urinary C-peptide immunoreactivity and glomerular filtration rate decreased. The duration of diabetes (years) was significantly associated with the prevalence of diabetic retinopathy (OR 1.05, 95% CI 1.03-1.07, P < 0.01), nephropathy (OR 1.03, 95% CI 1.01-1.05, P < 0.01) and neuropathy (OR 1.08, 95% CI 1.05-1.12, P < 0.01), but not with cerebrovascular disease (OR 1.01, 95% CI 0.99-1.03, P = 0.38), coronary heart disease (OR 1.02, 95% CI 1.00-1.04, P = 0.09) or peripheral artery disease (OR 1.02, 95%CI 0.99-1.05, P = 0.12) in the elderly patients after adjusting for the traditional risk factors of diabetic angiopathies. In contrast, the duration of diabetes showed a significant association with the prevalence of both diabetic micro- and macroangiopathies in the non-elderly patients.
  
  
  CONCLUSIONS
  It should be noted that atherosclerotic diseases are present in the clinical setting for the management of elderly diabetic patients independent of the duration of diabetes. Geriatr Gerontol Int 2017; 17: 24-30.
authors.affiliation: Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ito
authors.affiliation: Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Omoto
authors.affiliation: Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Abe
authors.affiliation: Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan.
authors.forename: Suzuko
authors.initials: S
authors.lastname: Matsumoto
authors.affiliation: Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shinozaki
authors.affiliation: Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Nishio
authors.affiliation: Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Antoku
authors.affiliation: Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan.
authors.forename: Mizuo
authors.initials: M
authors.lastname: Mifune
authors.affiliation: Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Togane
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000628:therapy; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D005260:Female; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D013997:Time Factors
chemical_list: D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin
keywords: atherosclerosis; diabetic macroangiopathy; diabetic microangiopathy; elderly; type 2 diabetes mellitus