title: A Metabolic Switch for Th17 Pathogenicity.
abstract: T helper 17 (Th17) cells are critical for host defense but can also drive autoimmunity. This divergent behavior is explored by Gaublomme et al. and Wang et al., who identify inflammation-associated genes by measuring gene expression in nearly 1,000 individual Th17 cells and show that CD5L affects the expression of pro-inflammatory genes by altering lipid synthesis.
authors.affiliation: Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: fred.davis@nih.gov.
authors.forename: Fred P
authors.initials: FP
authors.lastname: Davis
authors.affiliation: Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kanno
authors.affiliation: Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: john.oshea@nih.gov.
authors.forename: John J
authors.initials: JJ
authors.lastname: O'Shea
mesh_terms: D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000473:pathology*; D006801:Humans; D017423:Sequence Analysis, RNA; D059010:Single-Cell Analysis; D058504:Th17 Cells / Q000378:metabolism* / Q000473:pathology*