title: Terezine derivatives from the fungus Phoma herbarum PSU-H256.
abstract: Investigation of the fungus Phoma herbarum PSU-H256 isolated from a leaf of Hevea brasiliensis resulted in the isolation of eight terezine derivatives (E-L) together with four known compounds. Their structures were established by analysis of spectroscopic evidence. For terezines E and H, their structures were confirmed by single-crystal X-ray diffraction crystallography. In addition, the absolute configuration at C-7 in terezine E was established by Mosher's method. Terezines K and L were tested for antibacterial, antimalarial, antimycobacterial and cytotoxic activities, but were inactive.
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
authors.forename: Athip
authors.initials: A
authors.lastname: Maha
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand. Electronic address: vatcharin.r@psu.ac.th.
authors.forename: Vatcharin
authors.initials: V
authors.lastname: Rukachaisirikul
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
authors.forename: Saowanit
authors.initials: S
authors.lastname: Saithong
authors.affiliation: Natural Products Research Center of Excellence and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
authors.forename: Souwalak
authors.initials: S
authors.lastname: Phongpaichit
authors.affiliation: Natural Products Research Center of Excellence and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
authors.forename: Wimarak
authors.initials: W
authors.lastname: Poonsuwan
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand.
authors.forename: Jariya
authors.initials: J
authors.lastname: Sakayaroj
authors.affiliation: Department of Chemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
authors.forename: Patchreenart
authors.initials: P
authors.lastname: Saparpakorn
authors.affiliation: Department of Chemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
authors.forename: Supa
authors.initials: S
authors.lastname: Hannongbua
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D018360:Crystallography, X-Ray; D015394:Molecular Structure; D009842:Oligopeptides; D011719:Pyrazines / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D009842:Oligopeptides; D011719:Pyrazines; C093757:terezine A; C000610887:terezine E; C000610885:terezine K; C000610886:terezine L; C054285:H 256
keywords: Euphorbiaceae; Hevea brasiliensis; Phoma herbarum; Pyrazine; Pyrazinone