title: Targeting of proangiogenic signalling pathways in chronic inflammation.
abstract: Angiogenesis is de novo capillary outgrowth from pre-existing blood vessels. This process not only is crucial for normal development, but also has an important role in supplying oxygen and nutrients to inflamed tissues, as well as in facilitating the migration of inflammatory cells to the synovium in rheumatoid arthritis, spondyloarthritis and other systemic autoimmune diseases. Neovascularization is dependent on the balance of proangiogenic and antiangiogenic mediators, including growth factors, cytokines, chemokines, cell adhesion molecules and matrix metalloproteinases. This Review describes the various intracellular signalling pathways that govern these angiogenic processes and discusses potential approaches to interfere with pathological angiogenesis, and thereby ameliorate inflammatory disease, by targeting these pathways.
authors.affiliation: Amsterdam Rheumatology &Immunology Centre, Department of Experimental Immunology, Academic Medical Centre and University of Amsterdam, EULAR &FOCIS (Federation of Clinical Immunology Societies) Centre of Excellence, Meibergdreef 9, F4-105, 1105 AZ Amsterdam, Netherlands.
authors.forename: Sander W
authors.initials: SW
authors.lastname: Tas
authors.affiliation: Amsterdam Rheumatology &Immunology Centre, Department of Experimental Immunology, Academic Medical Centre and University of Amsterdam, EULAR &FOCIS (Federation of Clinical Immunology Societies) Centre of Excellence, Meibergdreef 9, F4-105, 1105 AZ Amsterdam, Netherlands.
authors.forename: Chrissta X
authors.initials: CX
authors.lastname: Maracle
authors.affiliation: Department of Rheumatology, Institute of Medicine, University of Debrecen, Faculty of Medicine, Nagyerdei Str. 98, Debrecen 4032, Hungary.
authors.forename: Emese
authors.initials: E
authors.lastname: Balogh
authors.affiliation: Department of Rheumatology, Institute of Medicine, University of Debrecen, Faculty of Medicine, Nagyerdei Str. 98, Debrecen 4032, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szekanecz
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000276:immunology; D018925:Chemokines / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D036341:Intercellular Signaling Peptides and Proteins / Q000276:immunology; D020782:Matrix Metalloproteinases / Q000276:immunology; D009389:Neovascularization, Pathologic / Q000276:immunology*; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology; D025241:Spondylarthritis / Q000188:drug therapy* / Q000276:immunology*; D013583:Synovial Membrane / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D020533:Angiogenesis Inhibitors; D015815:Cell Adhesion Molecules; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; D020782:Matrix Metalloproteinases