title: [A case of Marchiafava-Bignami disease suggesting vasogenic edema].
abstract: A 61-year-old alcoholic man was admitted to our hospital because of disturbance of consciousness. He also exhibited external ophthalmoplegia, diplopia and mild rigidity, but tendon reflex was normal. On brain MRI, diffusion weighted images (DWI) and apparent diffusion coefficient (ADC) map depicted high intensity in the splenium of the corpus callosum. DWI showed high intensity, but ADC map depicted iso-intensity in bilateral precentral gyri. Marchiafava-Bignami disease (MBD) was diagnosed. After intravenous drip of vitamin, his symptoms improved rapidly and the abnormal MRI findings in the splenium of the corpus callosum and bilateral precentral gyri disappeared gradually. MBD is pathologically characterized by demyelination and necrosis in the corpus callosum, which are generally caused by cytotoxic edema. Our case suggests that vasogenic edema may occur at the early stage of the MBD.
authors.affiliation: Department of Neurology, Saiseikai Otaru Hospital.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Manabu
authors.initials: M
authors.lastname: Matsuya
authors.forename: Kazuna
authors.initials: K
authors.lastname: Ikeda
authors.forename: Reiko
authors.initials: R
authors.lastname: Tsuda
authors.forename: Naomitsu
authors.initials: N
authors.lastname: Ariyoshi
authors.forename: Shun
authors.initials: S
authors.lastname: Shimohama
mesh_terms: D000437:Alcoholism / Q000150:complications; D001929:Brain Edema / Q000150:complications / Q000000981:diagnostic imaging*; D003337:Corpus Callosum / Q000000981:diagnostic imaging / Q000473:pathology; D003711:Demyelinating Diseases; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008297:Male; D054319:Marchiafava-Bignami Disease / Q000000981:diagnostic imaging* / Q000209:etiology; D008875:Middle Aged