title: [Oxytocin in cesarean-sections. What's new?].
abstract: Oxytocin is the uterotonic agent of choice in the prevention and treatment of postpartum uterine atony. Nevertheless, there is no consensus on the optimal dose and rate for use in cesarean sections. The use of high bolus doses (e.g., 10 IU of oxytocin) can determine deleterious cardiovascular changes for the patient, especially in situations of hypovolemia or low cardiac reserve. Furthermore, high doses of oxytocin for prolonged periods may lead to desensitization of oxytocin receptors in myometrium, resulting in clinical inefficiency.
authors.affiliation: Hospital Universitário da Universidade de São Paulo (HU-USP), São Paulo, SP, Brasil. Electronic address: eduardo@hu.usp.br.
authors.forename: Eduardo Tsuyoshi
authors.initials: ET
authors.lastname: Yamaguchi
authors.affiliation: Hospital e Maternidade Santa Joana, São Paulo, SP, Brasil.
authors.forename: Mônica Maria
authors.initials: MM
authors.lastname: Siaulys
authors.affiliation: Departamento de Cirurgia, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brasil.
authors.forename: Marcelo Luis Abramides
authors.initials: ML
authors.lastname: Torres
keywords: Cesarean section; Cesariana; Desensitization; Dessensibilização; Dose; Ocitocina; Oxytocin