title: Serum Cystatin C as an Inflammatory Marker in Exacerbated and Convalescent COPD Patients.
abstract: Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease with high morbidity and mortality rates. Cystatin C (Cys C) is a sensitive indicator for various chronic inflammatory diseases. In this study, we aimed to evaluate the role of Cys C in COPD patients comparing with the other well-known inflammatory markers. Ninety patients with acute exacerbated COPD were studied and were reassessed when convalescent. Ninety controls were matched for age, gender, body mass index, smoking index, and comorbidity. Serum Cys C was significantly increased in convalescent COPD patients compared with healthy controls and further increased in COPD patients with an acute exacerbation. Serum Cys C was positively correlated with hsCRP both in the exacerbation and convalescence periods of COPD and negatively correlated with FEV1% predicted and FEV1/FVC in the convalescent COPD patients. In conclusion, serum Cys C is a positive acute-phase reactant in COPD patients and might indicate systemic inflammation during the progression of COPD.
authors.affiliation: Department of Respiratory Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Fifth Road, Xi'an, Shaanxi, 710004, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Fifth Road, Xi'an, Shaanxi, 710004, China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Fifth Road, Xi'an, Shaanxi, 710004, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Respiratory Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Fifth Road, Xi'an, Shaanxi, 710004, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Shan
authors.affiliation: Department of Respiratory Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Fifth Road, Xi'an, Shaanxi, 710004, China.
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Fifth Road, Xi'an, Shaanxi, 710004, China.
authors.forename: Zongjuan
authors.initials: Z
authors.lastname: Ming
authors.affiliation: Department of Respiratory Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Fifth Road, Xi'an, Shaanxi, 710004, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Respiratory Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Fifth Road, Xi'an, Shaanxi, 710004, China.
authors.forename: Haijuan
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Respiratory Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Fifth Road, Xi'an, Shaanxi, 710004, China.
authors.forename: Yanqin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Respiratory Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Fifth Road, Xi'an, Shaanxi, 710004, China. 81276894@qq.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D055316:Cystatin C / Q000097:blood*; D018450:Disease Progression; D005260:Female; D005540:Forced Expiratory Flow Rates / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000473:pathology*
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D055316:Cystatin C
keywords: C-reactive protein; chronic obstructive pulmonary disease; cystatin C; inflammation; pulmonary function