title: Sesquiterpene-neolignans from Manglietia hookeri.
abstract: The comet assay-guided fractionation of the twigs of Manglietia hookeri resulted in the isolation of three sesquiterpene-neolignans, including a new one 5-allyl-2-(4-allyl-phenoxy)-3-[7-(1-hydroxy-1-methyl-ethyl)-1, 4a-dimethyl-decahydro-naphthalen-1-yloxy]-phenol (1), and eudesobovatol A (2) and eudesobovatol B (3), together with three lignans, obovatol (4), honokiol (5) and magnolol (6). Their structures were elucidated on the basis of spectral analysis and by comparison with related literature data. Compounds 1, 4-6 showed a protective effect on UV inductive DNA damage in mice lymphocyte cells, while compound 1 indicated the smallest Olive Tail Moment 7.34 ± 2.09 at 6 × 10(-6) μM.
authors.affiliation: a College of Life and Environmental Sciences , Minzu University of China , Beijing , P.R. China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Hu
authors.affiliation: a College of Life and Environmental Sciences , Minzu University of China , Beijing , P.R. China.
authors.forename: Xianjin
authors.initials: X
authors.lastname: Sui
authors.affiliation: a College of Life and Environmental Sciences , Minzu University of China , Beijing , P.R. China.
authors.forename: Yijing
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a College of Life and Environmental Sciences , Minzu University of China , Beijing , P.R. China.|b Beijing Engineering Research Center of Food Environment and Health , Minzu University of China , Beijing , P.R. China.
authors.forename: Wenshu
authors.initials: W
authors.lastname: Wang
authors.affiliation: a College of Life and Environmental Sciences , Minzu University of China , Beijing , P.R. China.|b Beijing Engineering Research Center of Food Environment and Health , Minzu University of China , Beijing , P.R. China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Wu
authors.affiliation: a College of Life and Environmental Sciences , Minzu University of China , Beijing , P.R. China.
authors.forename: Feiran
authors.initials: F
authors.lastname: Zhang
authors.affiliation: a College of Life and Environmental Sciences , Minzu University of China , Beijing , P.R. China.
authors.forename: Yuna
authors.initials: Y
authors.lastname: Tan
authors.affiliation: a College of Life and Environmental Sciences , Minzu University of China , Beijing , P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029562:Magnoliaceae / Q000737:chemistry*; D051379:Mice; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D017705:Lignans; D012717:Sesquiterpenes
keywords: Magnoliaceae; Manglietia hookeri; comet assay; sesquiterpene-neolignans