title: Lexical and sub-lexical reading skills and their correlation to clinical symptoms in young Chinese patients with schizophrenia.
abstract: Patients with schizophrenia often experience severe reading deficits such as oral reading and reading comprehension deficits. However, it is not known whether different types of lexical or sub-lexical components in reading are also impaired. In order to address this issue, the present study had 22 young Chinese patients with schizophrenia and 22 young Chinese normal controls undergo a battery of reading tests, which specifically measures lexical and sub-lexical components of reading in Chinese. The schizophrenic group further underwent Brief Psychiatric Rating Scale (BPRS) in order to ascertain the severity of patients' clinical symptoms. The results showed that compared to the controls, (1) the schizophrenic patients performed significantly poorly in orthographic processing, orthography-phonology mapping, and orthography-semantic mapping tests and further that (2) their performances in orthographic processing, and orthography-semantic mapping skill tests negatively correlated with the BPRS score. Note however that their ability to access their mental lexicon was intact. There is thus a clear need for studies with a larger sample-size and neurobiological measures which would lead to our better understanding of the behavioral as well as the neural relationships between schizophrenic patients, and their reading processing impairments, thus developing effective reading intervention programs for the schizophrenic patients.
authors.affiliation: Peking University Sixth Hospital, Beijing 100191, China; Peking University Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China.
authors.forename: Jiuju
authors.initials: J
authors.lastname: Wang
authors.affiliation: Peking University Sixth Hospital, Beijing 100191, China; Peking University Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Xia
authors.affiliation: Peking University Sixth Hospital, Beijing 100191, China; Peking University Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.affiliation: Peking University Sixth Hospital, Beijing 100191, China; Peking University Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China.
authors.forename: Wenxiang
authors.initials: W
authors.lastname: Quan
authors.affiliation: Peking University Sixth Hospital, Beijing 100191, China; Peking University Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China.
authors.forename: Ju
authors.initials: J
authors.lastname: Tian
authors.affiliation: Centre for Cognition and Neuroimaging, Brunel University London, Uxbridge, UK.
authors.forename: Taeko N
authors.initials: TN
authors.lastname: Wydell
authors.affiliation: Peking University Sixth Hospital, Beijing 100191, China; Peking University Institute of Mental Health, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China. Electronic address: dongwentian@bjmu.edu.cn.
authors.forename: Wentian
authors.initials: W
authors.lastname: Dong
mesh_terms: D000328:Adult; D002681:China; D004410:Dyslexia / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D011932:Reading; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis*; D063189:Symptom Assessment; D055815:Young Adult
keywords: Clinical symptoms; Mental lexicon; Schizophrenia; Sub-lexical & lexical reading skills