title: [DEFINITION OF INTERRELATION BETWEEN AMINOACID COMPOSITION OF URINE AND BONE TISSUE DENSITY AT CHILDREN WITH ACUTE LEUKAEMIA FOR ONCOHEMATOLOGICAL PATHOLOGY RISK GROUP FORMATION].
abstract: Age and sexual indexies of densitometry at patients with acute leukemia (AL) and healthy children are presented. 31% of children with AL during the initial period of disease had manifestations of the osteopenic syndrome. At patients with AL more often than at healthy children anomalies of development of front part of skull are defined. The partial contribution of free and peptides-connencted oxyproline in urine at AL patients differs in comparison with control group that is caused by modification or deficiency of the corresponding enzymes. 30% of patients with AL had raised concentration of free oxyproline in urine, and lowered glycine concentration that testifies to the increased disintegration of collagen and deficiency of tile plastic material necessary for collagene-forming processes. The obtained data should be considered for forming of risk group on oncohematological pathology at children.
authors.forename: V G
authors.initials: VG
authors.lastname: Bebeshko
authors.forename: E M
authors.initials: EM
authors.lastname: Bruslova
authors.forename: T T
authors.initials: TT
authors.lastname: Volodina
authors.forename: N M
authors.initials: NM
authors.lastname: Tsvietkova
authors.forename: L A
authors.initials: LA
authors.lastname: Lyashenko
authors.forename: T I
authors.initials: TI
authors.lastname: Pushkareva
authors.forename: V I
authors.initials: VI
authors.lastname: Voloshko
authors.forename: L P
authors.initials: LP
authors.lastname: Veselskaya
authors.forename: T A
authors.initials: TA
authors.lastname: Chernysh
authors.forename: I V
authors.initials: IV
authors.lastname: Trikhleb
mesh_terms: D000293:Adolescent; D000596:Amino Acids / Q000652:urine*; D015519:Bone Density; D047852:Chernobyl Nuclear Accident; D002648:Child; D003094:Collagen / Q000172:deficiency; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000473:pathology / Q000652:urine*; D008297:Male; D010024:Osteoporosis / Q000150:complications / Q000473:pathology / Q000652:urine*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000473:pathology / Q000652:urine*; D018570:Risk Assessment; D012886:Skull / Q000002:abnormalities
chemical_list: D000596:Amino Acids; D003094:Collagen