title: Fabrication and Characterization of Poly(ε-caprolactone)/α-Cyclodextrin Pseudorotaxane Nanofibers.
abstract: Multifunctional scaffolds comprising neat poly(ε-caprolactone) (PCL) and α-cyclodextrin pseudorotaxanated in α-cyclodextrin form have been fabricated using a conventional electrospinning process. Thorough in-depth characterizations were performed on the pseudorotaxane nanofibers prepared from chloroform (CFM) and CFM/dimethylformamide (DMF) utilizing scanning electron microscopy (SEM), transmission electron microscopy (TEM), rheology, differential scanning calorimetry (DSC), thermogravimetric analyses (TGA), wide-angle X-ray diffraction (WAXD), and Instron tensile testing. The results indicate the nanofibers obtained from chloroform retain the rotaxanated structure; while those obtained from CFM/DMF had significantly dethreaded during electrospinning. As a consequence, the nanowebs obtained from CFM showed higher moduli and lower elongations at break compared to neat PCL nanowebs and PCL/α-CD nanowebs electrospun from CFM/DMF.
authors.affiliation: Fiber and Polymer Science Program, ‡Department of Forest Biomaterials, §Department of Biomedical Engineering, and ∥Department of Materials Science and Engineering, North Carolina State University , Raleigh, North Carolina 27695, United States.
authors.forename: Ganesh
authors.initials: G
authors.lastname: Narayanan
authors.affiliation: Fiber and Polymer Science Program, ‡Department of Forest Biomaterials, §Department of Biomedical Engineering, and ∥Department of Materials Science and Engineering, North Carolina State University , Raleigh, North Carolina 27695, United States.
authors.forename: Remil
authors.initials: R
authors.lastname: Aguda
authors.affiliation: Fiber and Polymer Science Program, ‡Department of Forest Biomaterials, §Department of Biomedical Engineering, and ∥Department of Materials Science and Engineering, North Carolina State University , Raleigh, North Carolina 27695, United States.
authors.forename: Matthew
authors.initials: M
authors.lastname: Hartman
authors.affiliation: Fiber and Polymer Science Program, ‡Department of Forest Biomaterials, §Department of Biomedical Engineering, and ∥Department of Materials Science and Engineering, North Carolina State University , Raleigh, North Carolina 27695, United States.
authors.forename: Ching-Chang
authors.initials: CC
authors.lastname: Chung
authors.affiliation: Fiber and Polymer Science Program, ‡Department of Forest Biomaterials, §Department of Biomedical Engineering, and ∥Department of Materials Science and Engineering, North Carolina State University , Raleigh, North Carolina 27695, United States.
authors.forename: Ramiz
authors.initials: R
authors.lastname: Boy
authors.affiliation: Fiber and Polymer Science Program, ‡Department of Forest Biomaterials, §Department of Biomedical Engineering, and ∥Department of Materials Science and Engineering, North Carolina State University , Raleigh, North Carolina 27695, United States.
authors.forename: Bhupender S
authors.initials: BS
authors.lastname: Gupta
authors.affiliation: Fiber and Polymer Science Program, ‡Department of Forest Biomaterials, §Department of Biomedical Engineering, and ∥Department of Materials Science and Engineering, North Carolina State University , Raleigh, North Carolina 27695, United States.
authors.forename: Alan E
authors.initials: AE
authors.lastname: Tonelli
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry*; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry; D043862:Rotaxanes / Q000138:chemical synthesis* / Q000737:chemistry; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction; D047391:alpha-Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D043862:Rotaxanes; D047391:alpha-Cyclodextrins; C016240:polycaprolactone; C032613:alpha-cyclodextrin