title: Different co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients.
abstract: BACKGROUND
  In Italy, the nsLTP (Pru p 3) has been identified as the most frequent cause of food allergy and anaphylaxis. In order to estimate the risk assessment in peach allergy, we investigated the presence of correlations between the levels of sIgE to Pru p 3 with the severity of the clinical symptoms in two Pru p 3 positive populations from two different areas of Italy.
  
  
  METHODS
  133 consecutively Pru p 3 positive patients were recruited from South Italy, where the prevalence of PR-10 and profilin sensitization is low, and from North-East Italy, where the sensitization to pathogenesis related protein -10 (PR-10) and profilin is higher. Skin prick test (SPT) to peach extract and sIgE to peach panallergens were performed.
  
  
  RESULTS
  All 133 patients were positive to SPT to peach extract and to sIgE to Pru p 3. The North-East population was simultaneously positive to Pru p 1 (42.8 %) and Pru p 4 (12.7 %), while no Southern patients were positive to PR-10 or to profilin. A significant difference in the levels of sIgE to Pru p 3 was found only in South Italy Pru p 3 + patients vs. asymptomatic patients (p = 0.01) and in mild reactions vs. severe reactions (p = 0.0008). In South Italy patients, it was also found a significant correlation between the severity of the clinical reaction and the levels of sIgE to Pru p 3 (p = 0.001).
  
  
  CONCLUSIONS
  Level of sIgE to Pru p 3 indicates the possibility of development a severe food allergic reaction. Pru p 3 positive patients from different geographical areas and with different co-sensitizations to Pru p 1 and/or Pru p 4 could have a different risk assessment in peach allergy.
authors.affiliation: Allergy Diseases Center "Prof. G. Bonsignore", Institute of Biomedicine and Molecular Immunology "A. Monroy"(IBIM)-National Research Council (CNR), Palermo, Italy.
authors.forename: Carina Gabriela
authors.initials: CG
authors.lastname: Uasuf
authors.affiliation: Allergy and Clinical Immunology Unit, A.O "S. Maria degli Angeli di Pordenone", Pordenone, Italy.
authors.forename: Danilo
authors.initials: D
authors.lastname: Villalta
authors.affiliation: Allergy and Clinical Immunology Unit, A.O "S. Maria degli Angeli di Pordenone", Pordenone, Italy.
authors.forename: Maria Elisabetta
authors.initials: ME
authors.lastname: Conte
authors.affiliation: Allergy Diseases Center "Prof. G. Bonsignore", Institute of Biomedicine and Molecular Immunology "A. Monroy"(IBIM)-National Research Council (CNR), Palermo, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Di Sano
authors.affiliation: Clinical Pathology, Allergy Unit, Buccheri La Ferla Hospital, Palermo, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Barrale
authors.affiliation: Clinical Pathology, Allergy Unit, Buccheri La Ferla Hospital, Palermo, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cantisano
authors.affiliation: Allergy Diseases Center "Prof. G. Bonsignore", Institute of Biomedicine and Molecular Immunology "A. Monroy"(IBIM)-National Research Council (CNR), Palermo, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Pace
authors.affiliation: Allergy Diseases Center "Prof. G. Bonsignore", Institute of Biomedicine and Molecular Immunology "A. Monroy"(IBIM)-National Research Council (CNR), Palermo, Italy.
authors.forename: Mark
authors.initials: M
authors.lastname: Gjomarkaj
authors.affiliation: School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Gangemi
authors.affiliation: Clinical Pathology, Allergy Unit, Buccheri La Ferla Hospital, Palermo, Italy.
authors.forename: Ignazio
authors.initials: I
authors.lastname: Brusca
keywords: Anaphylactic biomarker; Co-sensitization; Molecular allergy based diagnosis; Peach allergy; Risk assessment; nsLTP; sIgE to Pru p 3