title: Overcoming Antigen Escape with CAR T-cell Therapy.
abstract: Sotillo and colleagues describe the molecular events associated with apparent loss of target antigen expression following CAR T-cell therapy. We propose that broader immune activation is required to prevent outgrowth of tumor antigen escape variants following targeted therapies.
authors.affiliation: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Hollie J
authors.initials: HJ
authors.lastname: Jackson
authors.affiliation: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, New York. Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York. brentjer@mskcc.org.
authors.forename: Renier J
authors.initials: RJ
authors.lastname: Brentjens
mesh_terms: D000951:Antigens, Neoplasm / Q000378:metabolism; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D016219:Immunotherapy, Adoptive; D009369:Neoplasms / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm; D011948:Receptors, Antigen, T-Cell