title: [A case of ANCA-associated vasculitis with esophageal stenosis and pseudodiverticulosis].
abstract: A previously healthy 67-year-old woman visited our institution because of cough that had persisted for 3 months, fever at night, left tinnitus, and hearing loss from 1 month prior. She lost 2 kg in weight over the last 6 months, and her C-reactive protein level and leukocyte count were increased. Computed tomography revealed multiple small nodules in both lung fields. She was admitted to our hospital for further examination to determine the optimal medical treatment. Because the myeloperoxidase antineutrophil cytoplasmic antibody (ANCA) titer was 132.5 U/mL and microscopic hematuria was observed, vasculitis was considered. A percutaneous kidney biopsy was performed and revealed microscopic polyangiitis. For this reason, the case was diagnosed as ANCA-associated vasculitis. Esophageal stenosis and pseudodiverticulosis were observed on upper gastrointestinal endoscopy. Pathological changes due to inflammation were observed in the biopsy and esophagography. Pulse therapy with methylprednisolone at 1,000 mg/day was administered to the patient as the first-line treatment, followed by prednisolone at 40 mg/day as remission induction treatment. Bloody urine and lung shadows disappeared, and the steroid dose was tapered at hospital discharge. The patient's hearing ability and the esophageal pathological change that was considered to be ANCA-associated vasculitis were improved. Although a few studies have reported that esophageal stenosis and pseudodiverticulosis accompany ANCA-associated vasculitis, we think that examination for the possible presence of gastrointestinal tract lesions is important.
authors.forename: Soh
authors.initials: S
authors.lastname: Suzuki
authors.forename: Manabu
authors.initials: M
authors.lastname: Ohishi
authors.forename: Norimasa
authors.initials: N
authors.lastname: Katayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koizumi
authors.forename: Masao
authors.initials: M
authors.lastname: Namiki
mesh_terms: D000368:Aged; D000974:Antibodies, Antinuclear / Q000276:immunology*; D001706:Biopsy; D004940:Esophageal Stenosis / Q000209:etiology* / Q000473:pathology; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D014057:Tomography, X-Ray Computed; D014657:Vasculitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
chemical_list: D000974:Antibodies, Antinuclear