title: Center-Related Determinants of VKA Anticoagulation Quality: A Prospective, Multicenter Evaluation.
abstract: BACKGROUND
  Center-specific TTR (c-TTR) is a measure reporting the mean patient TTR within an anticoagulation clinic describing the quality of anticoagulant monitoring offered by that clinic. c-TTR has a considerable between-center variation, but its determinants are poorly understood.
  
  
  OBJECTIVE
  We aimed at evaluating which clinical, procedural or laboratory factors could be associated with c-TTR variability in a multicenter, observational cross-sectional study over a five-year period.
  
  
  METHODS
  Data from 832,204 individual patients followed for VKA therapy in 292 Centers affiliated with the Italian Federation of Anticoagulation Clinics (FCSA) were analyzed. c-TTR was computed based on the TTR of patients followed at each Center, and a mixed linear regression model was used for a predefined set of explanatory variables.
  
  
  RESULTS
  The Center next-visit interval ratio (the mean number of days after a visit with an INR outside the therapeutic range, divided by the days after a visit with an INR within the therapeutic range), the Center mean patient INR and the Center laboratory performance at EQA proficiency testing were the only variables that were independently associated with c-TTR (β-coefficients -17.32, 9.67, and -0.11, respectively; r2 = 0.635).
  
  
  CONCLUSIONS
  These findings suggest that c-TTR associates with proactive strategies aimed at keeping patients very close to their target INR with a prompt re-evaluation of those patients with under- or over-therapeutic INR.
authors.affiliation: Department of Hematology, S. Bortolo Hospital, Vicenza, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Tosetto
authors.affiliation: Hemostasis Center, Fidenza-Vaio Hospital, Fidenza, Italy.
authors.forename: Cesare
authors.initials: C
authors.lastname: Manotti
authors.affiliation: Department of Internal Medicine, University of Cagliari, Cagliari, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Marongiu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage / Q000493:pharmacokinetics; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D011446:Prospective Studies; D011787:Quality of Health Care
chemical_list: D000925:Anticoagulants