title: Increased S100B Levels in Cannabis Use Disorder.
abstract: BACKGROUND
  It has been determined that cannabis has adverse effects on brain tissue, and that increased S100 calcium binding protein B (S100B) blood levels are markers of neuronal damage. Therefore, the aim of this study was to evaluate the S100B levels in cannabis use disorder.
  
  
  METHODS
  Thirty-two patients with cannabis use disorder and 31 matched healthy controls were enrolled in this study. Appropriate blood samples were taken from the enrolled subjects, and the serum S100B protein levels were measured with an electrochemiluminescence immunoassay for the quantification of the protein.
  
  
  RESULTS
  We found significantly increased S100B protein levels in patients with cannabis use disorder. The mean serum concentration of S100B was 0.081 ± 0.018 μg/l in patients with cannabis use disorder, and 0.069 ± 0.018 μg/l in the control group (p = 0.008).
  
  
  CONCLUSIONS
  Our data suggest that elevated S100B protein levels might indicate neuronal damage in the brains of people with cannabis use disorder.
authors.affiliation: Department of Psychiatry, Siverek State Hospital, Sanliurfa, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Bayazit
authors.forename: Erdinc
authors.initials: E
authors.lastname: Cicek
authors.forename: Salih
authors.initials: S
authors.lastname: Selek
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.forename: I Fatih
authors.initials: IF
authors.lastname: Karababa
authors.forename: Hasan
authors.initials: H
authors.lastname: Kandemir
authors.forename: Sultan
authors.initials: S
authors.lastname: Basmaci Kandemir
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D064568:S100 Calcium Binding Protein beta Subunit