title: Towards More Personalized Surgical Indications for Thoracic Aortic Dilatation: Are We There Yet?
abstract: Thoracic aortic aneurysms remain an important cause of death in the general population. The key to improving patient prognosis with thoracic aortic dilatation lies in early identification and tailored management strategies. Advances in the understanding of the molecular mechanisms of aneurysm formation, the natural history of disease, and clinical risk factors have led to significant improvements in patient management and overall outcomes. In the past decade, identification of the genetic basis of disease, together with wider availability of molecular testing, ushered in a new era for a tailored approach to the management of patients with thoracic aortic aneurysms. In this viewpoint, we explore these various iterative steps and future challenges.
authors.affiliation: Division of Cardiac Surgery, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. Electronic address: i.elhamamsy@icm-mhi.org.
authors.forename: Ismail
authors.initials: I
authors.lastname: El-Hamamsy
authors.affiliation: Harefield Heart Science Center, Harefield Hospital, Imperial College London, London, United Kingdom.
authors.forename: Magdi H
authors.initials: MH
authors.lastname: Yacoub
mesh_terms: D000784:Aortic Dissection / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery*; D006801:Humans; D057285:Precision Medicine / Q000379:methods*; D011379:Prognosis; D012307:Risk Factors; D014656:Vascular Surgical Procedures / Q000379:methods*