title: Cancer and Aging: General Principles, Biology, and Geriatric Assessment.
abstract: Cancer is a disease of aging as older adults are much more likely to develop cancer compared with their younger counterparts. Understanding the biology of cancer and aging remains complex, and numerous theories regarding the relationship between the two have been proposed. Cancer treatment decisions in older patients are particularly challenging, because the evidence is scarce and the risk of toxicity increases with age. Determination of biologic age is essential due to heterogeneity of functional status, comorbidity, and physiologic reserves between patients of the same chronologic age.
authors.affiliation: Department of Medical Oncology, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA.
authors.forename: Daneng
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Internal Medicine, Tergooi Hospitals, Van Riebeeckweg 212, Hilversum 1213XZ, The Netherlands.
authors.forename: Nienke A
authors.initials: NA
authors.lastname: de Glas
authors.affiliation: Department of Medical Oncology, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA. Electronic address: Ahurria@coh.org.
authors.forename: Arti
authors.initials: A
authors.lastname: Hurria
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015577:Geriatric Assessment; D006299:Health Services for the Aged; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D010346:Patient Care Management; D012307:Risk Factors
keywords: Aging; Biology; Biomarker; Cancer; Geriatric assessment