title: Current Drug Managements of Wilson's Disease: From West to East.
abstract: Wilson's disease (WD), also called hepatolenticular degeneration, is an autosomal recessive inheritance disorder of copper metabolism characterized by the multiple mutations in the ATP-ase 7B gene of chromosome 13q. About half of the WD patients have neurological or psychiatric symptoms. As WD is a kind of medicable or nearly curable neurodegenerative disease in the field of medicine, early consideration/examination and without delay/ life-long treatment usually lead to better prognoses. The drugs, also named as anticopper agents, are commonly used in clinics including D-penicillamine, trientine, sodium dimercaptosuccinate, dimercaptosuccinic acid, zinc and tetrathiomolybdate. This provides detailed reviews about these medicines.
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Li
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.forename: Zhi-Fei
authors.initials: ZF
authors.lastname: You
authors.affiliation: Institute of Neurology, Anhui College of TCM, Hefei, China, 230026. yrm724120@sina.com.
authors.forename: Ren-Min
authors.initials: RM
authors.lastname: Yang
authors.affiliation: Department of Neurology, Shanghai First People's Hospital, Shanghai Jiao-Tong University, China, 200080. wangxp@ustc.edu.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Wang
mesh_terms: D002614:Chelating Agents / Q000627:therapeutic use*; D003300:Copper / Q000378:metabolism; D006527:Hepatolenticular Degeneration / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008516:Medicine, Chinese Traditional; D008982:Molybdenum / Q000627:therapeutic use; D010396:Penicillamine / Q000627:therapeutic use; D004113:Succimer / Q000627:therapeutic use; D016896:Treatment Outcome; D014266:Trientine / Q000627:therapeutic use; D015032:Zinc / Q000627:therapeutic use
chemical_list: D002614:Chelating Agents; D003300:Copper; D008982:Molybdenum; C020809:tetrathiomolybdate; D004113:Succimer; D010396:Penicillamine; D015032:Zinc; D014266:Trientine