title: Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus.
abstract: The adult hippocampus generates functional dentate granule cells (GCs) that release glutamate onto target cells in the hilus and cornus ammonis (CA)3 region, and receive glutamatergic and γ-aminobutyric acid (GABA)ergic inputs that tightly control their spiking activity. The slow and sequential development of their excitatory and inhibitory inputs makes them particularly relevant for information processing. Although they are still immature, new neurons are recruited by afferent activity and display increased excitability, enhanced activity-dependent plasticity of their input and output connections, and a high rate of synaptogenesis. Once fully mature, new GCs show all the hallmarks of neurons generated during development. In this review, we focus on how developing neurons remodel the adult dentate gyrus and discuss key aspects that illustrate the potential of neurogenesis as a mechanism for circuit plasticity and function.
authors.affiliation: Department of Fundamental Neurosciences, University of Lausanne, CH-1005 Lausanne, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Toni
authors.affiliation: Fundación Instituto Leloir (IIBBA-CONICET), 1405 Buenos Aires, Argentina.
authors.forename: Alejandro F
authors.initials: AF
authors.lastname: Schinder
mesh_terms: D018891:Dentate Gyrus / Q000166:cytology / Q000254:growth & development*; D006624:Hippocampus / Q000166:cytology* / Q000254:growth & development; D008954:Models, Biological; D009415:Nerve Net; D055495:Neurogenesis; D009473:Neuronal Plasticity; D009474:Neurons / Q000166:cytology; D013569:Synapses / Q000502:physiology