title: Comparison of Serum and Salivary Antioxidants in Patients with Temporomandibular Joint Disorders and Healthy Subjects.
abstract: OBJECTIVE
  Temporomandibular dysfunction (TMD) is a group of disorders in the facial region and temporomandibular joint (TMJ). Biomarkers are assumed to play a role in pain and early detection of destruction. The aim of this study was to compare the saliva and serum antioxidant levels in patients with TMD and healthy subjects.
  
  
  METHODS
  This case-control study was conducted on 28 TMD patients without pain, 28 TMD patients with pain and 28 healthy controls. The total antioxidant capacity of saliva and serum of patients was measured. Data were analyzed using ANOVA and Tamhane's test.
  
  
  RESULTS
  The mean (±SD) total antioxidant capacity of serum (plasma TAC) was 0.8900 (±0.11627) mmol/L in TMD patients with pain, 1.2717 (±0.18711) mmol/L in TMD patients without pain and 1.7500(±0.18711) mmol/L in the control group. Based on ANOVA, the difference in this regard among the three groups was statistically significant (P=0.000). The mean salivary TAC was 1.34 (±0.06721) mmol/L in TMD patients with pain, 1.42 (±0.16677) mmol/L in TMD patients without pain and 1.35 (±0.11627) mmol/L in the control group. The difference in this respect among the three groups was not significant (P>0.05).
  
  
  CONCLUSIONS
  The mean plasma TAC in TMD patients with/without pain was significantly lower than that in the control group but no significant difference was detected in salivary TAC among the three groups.
authors.affiliation: Assistant Professor, Department of Prosthodontics, Islamic Azad University, Dental Branch, Tehran, Iran.
authors.forename: Shirin
authors.initials: S
authors.lastname: Lawaf
authors.affiliation: Associate Professor, Department of Oral Medicine, Islamic Azad University, Dental Branch, Tehran, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Azizi
authors.affiliation: Oral Medicine Specialist, Tehran, Iran.
authors.forename: Tohid
authors.initials: T
authors.lastname: Tabarestani
keywords: Antioxidants; Oxidative Stress; Saliva; Serum; Temporomandibular Joint Disorders