title: IGFBP3 polymorphisms and risk of esophageal cancer in a Chinese population.
abstract: Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide. It is very aggressive with a poor prognosis. Besides environmental risk factors, genetic factors might contribute to the esophageal cancer carcinogenesis. To evaluate the association between the risk of esophageal squamous cell carcinoma (ESCC) and genetic variants in IGFBP3, we conducted a hospital-based case-control study to assess the genetic effects of these SNPs. A total of 380 esophageal squamous cell carcinoma (ESCC) cases and 380 controls were recruited for this study. The genotypes were determined using a matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The IGFBP3 single nucleotide polymorphisms (SNPs) rs2270628 C>T, rs10282088 C>A, and rs3110697 G>A were associated with a significantly decreased risk of ESCC. However, our results were obtained with a limited sample size. To confirm the current findings, larger studies with other ethnic populations are required.
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu Province, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu Province, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Thoracic Surgery, The Union Clinical Medical College of Fujian Medical University Fuzhou, Fujian Province, China.
authors.forename: Shuchen
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Cardiology, The People's Hospital of Xishuangbanna Dai Autonomous Prefecture Jinghong, Yunnan Province, China.
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Microbiology and Immunology, Medical School of Southeast University Nanjing, Jiangsu Province, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Qiu
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu Province, China.
authors.forename: Haiyong
authors.initials: H
authors.lastname: Gu
keywords: Esophageal squamous cell carcinoma; IGFBP3; SNPs; molecular epidemiology