title: Zinc Deficiency Increases Serum Concentrations of Parathyroid Hormone through a Decrease in Serum Calcium and Induces Bone Fragility in Rats.
abstract: We hypothesized that a zinc-deficient diet alters the mineral (calcium, magnesium, and phosphorus) components of bones, as well as hormones related to bone remodeling, and negatively affects bone metabolism. Four-week-old male Wistar rats were randomly assigned to one of three groups for 4 wk: a zinc-adequate group (C, 30 ppm); a zinc-deficient group (ZD, 1 ppm); and a pair-fed group (PF, 30 ppm), which was pair-fed to the ZD group. Bone mineral density and bone mechanical properties were reduced in the ZD group compared to the C and PF groups. Compared with the C and PF groups, serum osteocalcin, a bone formation marker, was reduced in the ZD group. Conversely, urine deoxypyridinoline, a bone resorption marker, was increased in the ZD group compared to the C and PF groups. Calcium and phosphorus concentrations in bone were not different among all groups. The bone magnesium concentration was significantly higher in the ZD group than in the PF and C groups. Interestingly, compared with the C and PF groups, the ZD group showed a reduction in serum calcium concentration along with an increase in serum parathyroid hormone (PTH) concentration. Although serum 1,25-dihydroxycholecalciferol concentration was significantly higher in the ZD and PF groups than in the C group, the rate of apparent calcium absorption was significantly lower in the ZD group than in the C and PF groups. Therefore, zinc deficiency is suspected to cause an increase in serum PTH concentration owing to an inability to maintain calcium homeostasis, resulting in bone fragility.
authors.affiliation: Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture.
authors.forename: Takako
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Kajita
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Katsumata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuzaki
authors.forename: Kazuharu
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D015519:Bone Density; D001862:Bone Resorption / Q000097:blood*; D001842:Bone and Bones / Q000378:metabolism*; D002117:Calcitriol / Q000378:metabolism; D002118:Calcium / Q000097:blood* / Q000378:metabolism; D004032:Diet; D008274:Magnesium / Q000378:metabolism; D008297:Male; D015675:Osteocalcin / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood*; D010758:Phosphorus / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000097:blood* / Q000172:deficiency*
chemical_list: D010281:Parathyroid Hormone; D015675:Osteocalcin; D010758:Phosphorus; D002117:Calcitriol; D008274:Magnesium; D015032:Zinc; D002118:Calcium