title: GSTM1 Gene Polymorphism is Implicated in Increased Susceptibility to Prostate Cancer in Caucasians and Asians.
abstract: Published reports on the relationship between GSTM1 gene polymorphisms and prostate cancer risk are heterogeneous in their conclusions, and the significance of these polymorphisms is still debated. This meta-analysis was performed to attempt to combine comparable studies, thereby increasing sample size and statistical significance in order to obtain a better evaluation of the association between GSTM1 polymorphisms and prostate cancer risk. The association investigations were identified from PubMed, Cochrane Library, and China Biological Medicine Database on March 1, 2014. Forty-three reports were recruited into this meta-analysis that contained data from 6741 patients and 9053 controls. There was a marked association between the GSTM1 null genotype and prostate cancer risk in the overall population (odds ratio = 1.39, 95% confidence interval: 1.21-1.60, P <00001), caucasians (odds ratio = 1.48, 95% confidence interval: 1.23-1.79, P <0001) and Asians (odds ratio = 1.62, 95% confidence interval: 1.16-2.27, P = .005). However, the GSTM1 null genotype was not associated with prostate cancer risk in Africans (odds ratio = 0.77, 95% confidence interval: 0.53-1.13, P = 0.19) and African Americans (odds ratio = 1.00, 95% confidence interval: 0.69-1.45, P = 0.99). In conclusion, GSTM1 null genotype was a risk factor to predict the prostate cancer risk in the overall population, Caucasians, and Asians. Although compelling, limitations inherent to meta-analysis, study design of the individual studies, and most importantly, possible gene-gene and gene-environment interactions, as well as the potential involvement of glutathione S-transferases in multiple cellular processes make drawing definite conclusions difficult.
authors.affiliation: Department of Urology Surgery, the Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Zhong-Yang
authors.initials: ZY
authors.lastname: Wang
authors.affiliation: Department of Nephrology, Huadu District People's Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Li
authors.affiliation: Department of Nephrology, the Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Zongpei
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Nephrology, the Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China tianbiaozhou@163.com.
authors.forename: Tian-Biao
authors.initials: TB
authors.lastname: Zhou
authors.affiliation: Cellular Stress and Ageing Program, Bionanoscience and Bio-Imaging Program, Bio&Nano-Solutions, Bielefeld, Germany.
authors.forename: Gregor P C
authors.initials: GP
authors.lastname: Drummen
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics*
chemical_list: D005982:Glutathione Transferase
keywords: gene polymorphism; glutathione S-transferase M1; meta-analysis; prostate cancer