title: The anti-inflammatory and analgesic properties of prosopis chilenses in rats.
abstract: BACKGROUND
  Prosopis chilensis is used locally in Sudan for inflammatory conditions of joints; however, literature lacks scientific evidence for anti-inflammatory effect of this plant.
  
  
  OBJECTIVE
  To evaluate anti-inflammatory and analgesic effects of prosopis chilenses.
  
  
  METHODS
  Edema inhibition percent (EI %) and hot plate method were used to evaluate anti-inflammatory and analgesic effects of Prosopis chilenses in Wistar albino rats. Anti-inflammatory and analgesic effects of Prosopis chilenses were compared to indomethacin and acetylsalicylic acid respectively.
  
  
  RESULTS
  Ethanolic extract of prosopis chilensis at a dose of 200 and 100mg/kg body weight achieved peak EI% (EI% = 96.1%) and (EI% = 94.4%) three and four hours after oral dosing respectively. The maximum EI% for indomethacin was 97.0% and was recorded after 4 hours following oral administration of the drug at a dose of 5 mg/kg body weight. Prosopis chilensis extracts at doses of 100 and 200 mg/kg body weight significantly increased the rats' response time to hot plate compared to acetylsalicylic acid at a dose rate of 100mg/kg body weight (P<0.05).
  
  
  CONCLUSIONS
  The current results suggest potential anti-inflammatory and analgesic effects of prosopis chilenses. Relevance of these effects to prosopis chilenses phy-to-constituents was discussed.
authors.affiliation: Department of Pharmacology, Faculty of Medicine and Health Sciences Alneelain University, Sudan.
authors.forename: M A
authors.initials: MA
authors.lastname: Abodola
authors.affiliation: Department of Physiology, Faculty of Medicine and Health Sciences Alneelain University, Sudan and College of Medicine, Qassim University, KSA.
authors.forename: M F
authors.initials: MF
authors.lastname: Lutfi
authors.affiliation: Deanship of Scientific Research, University of Science and Technology, Sudan.
authors.forename: A O
authors.initials: AO
authors.lastname: Bakhiet
authors.affiliation: Head Department of Pharmacology, Medicinal and Aromatic Plant Research Institute, National Center of Research, Sudan.
authors.forename: A H
authors.initials: AH
authors.lastname: Mohamed
keywords: analgesic; anti-inflammatory; prosopis chilenses