title: Interventional approaches to mitral regurgitation. What's in the pipeline?
abstract: Mitral regurgitation (MR) is the most prevalent valvular heart disease in the Western world. Surgical repair is the gold standard for the treatment of degenerative MR in low-risk patients. Given the rising number of patients with functional MR and higher operative risk due to relevant comorbidities and increasing age, interventional approaches to repair or replace diseased mitral valves are on the rise. However, the complex anatomy and physiology of the mitral valve and its adjacent valve apparatus bear major challenges. To date, only the MitraClip device has been used in a large number of patients; however, several other devices and systems specifically targeted at different underlying pathologies of MR are currently under development. In addition to valve repair, the first steps toward mitral valve replacement have been taken. The present article reviews the current state of the art of interventional approaches to mitral valve disease and its future perspectives.
authors.affiliation: Klinik für Kardiologie, Pneumologie, Angiologie und internistische Intensivmedizin, Herzzentrum Uniklinik Köln, Klinik III für Innere Medizin, Kerpener Str. 62, 50937, Cologne, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Mauri
authors.affiliation: Klinik für Kardiologie, Pneumologie, Angiologie und internistische Intensivmedizin, Herzzentrum Uniklinik Köln, Klinik III für Innere Medizin, Kerpener Str. 62, 50937, Cologne, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Baldus
authors.affiliation: Klinik für Kardiologie, Pneumologie, Angiologie und internistische Intensivmedizin, Herzzentrum Uniklinik Köln, Klinik III für Innere Medizin, Kerpener Str. 62, 50937, Cologne, Germany. volker.rudolph@uk-koeln.de.
authors.forename: V
authors.initials: V
authors.lastname: Rudolph
mesh_terms: D006350:Heart Valve Prosthesis / Q000639:trends*; D019918:Heart Valve Prosthesis Implantation / Q000639:trends*; D006801:Humans; D008943:Mitral Valve / Q000601:surgery*; D058386:Mitral Valve Annuloplasty / Q000295:instrumentation* / Q000639:trends*; D008944:Mitral Valve Insufficiency / Q000601:surgery*; D011474:Prosthesis Design / Q000639:trends
keywords: MitraClip; Mitral regurgitation; Review; Transcatheter mitral valve repair; Transcatheter mitral valve replacement