title: Colchicine for cardiovascular medicine.
abstract: Colchicine is an ancient drug with anti-inflammatory effects especially on neutrophils. These cells are critically involved in pericardial and atherosclerotic plaques inflammation, thus representing a new potential target for new therapies to treat and especially prevent cardiovascular events such as pericarditis, atrial fibrillation triggered by inflammation and ischemic vascular events. The aim of the present review is to briefly review the essential pharmacology and explore potential efficacy and safety of colchicine for new emerging cardiovascular indications.
authors.affiliation: Cardiology Department, Maria Vittoria Hospital & Department of Public Health & Pediatrics, University of Torino, Torino, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Imazio
authors.affiliation: University Division of Cardiology, Department of Medical Sciences, Città della Salute e della Scienza, University of Torino, Torino, Italy.
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Gaita
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003078:Colchicine / Q000494:pharmacology*; D000075202:Contraindications; D006801:Humans; D056687:Off-Label Use
chemical_list: D000893:Anti-Inflammatory Agents; D003078:Colchicine
keywords: acute coronary syndrome; atrial fibrillation; colchicine; pericarditis; restenosis; stable angina