title: Genome of Rhodnius prolixus, an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection.
abstract: Rhodnius prolixus not only has served as a model organism for the study of insect physiology, but also is a major vector of Chagas disease, an illness that affects approximately seven million people worldwide. We sequenced the genome of R. prolixus, generated assembled sequences covering 95% of the genome (∼ 702 Mb), including 15,456 putative protein-coding genes, and completed comprehensive genomic analyses of this obligate blood-feeding insect. Although immune-deficiency (IMD)-mediated immune responses were observed, R. prolixus putatively lacks key components of the IMD pathway, suggesting a reorganization of the canonical immune signaling network. Although both Toll and IMD effectors controlled intestinal microbiota, neither affected Trypanosoma cruzi, the causal agent of Chagas disease, implying the existence of evasion or tolerance mechanisms. R. prolixus has experienced an extensive loss of selenoprotein genes, with its repertoire reduced to only two proteins, one of which is a selenocysteine-based glutathione peroxidase, the first found in insects. The genome contained actively transcribed, horizontally transferred genes from Wolbachia sp., which showed evidence of codon use evolution toward the insect use pattern. Comparative protein analyses revealed many lineage-specific expansions and putative gene absences in R. prolixus, including tandem expansions of genes related to chemoreception, feeding, and digestion that possibly contributed to the evolution of a blood-feeding lifestyle. The genome assembly and these associated analyses provide critical information on the physiology and evolution of this important vector species and should be instrumental for the development of innovative disease control methods.
authors.affiliation: Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, Brazil; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; rdmesquita@iq.ufrj.br edotson@cdc.gov pedro@bioqmed.ufrj.br.
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authors.initials: RD
authors.lastname: Mesquita
authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
authors.forename: Raquel J
authors.initials: RJ
authors.lastname: Vionette-Amaral
authors.affiliation: Biological Sciences, Simon Fraser University, Burnaby, BC, Canada V5A 1S6;
authors.forename: Carl
authors.initials: C
authors.lastname: Lowenberger
authors.affiliation: Centro Regional de Estudios Genomicos, Universidad Nacional de La Plata, La Plata 1900, Argentina; Centro de Bioinvestigaciones, Universidad Nacional del Noroeste de Buenos Aires, 2700 Pergamino, Argentina;
authors.forename: Rolando
authors.initials: R
authors.lastname: Rivera-Pomar
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil;
authors.forename: Fernando A
authors.initials: FA
authors.lastname: Monteiro
authors.affiliation: McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108;
authors.forename: Patrick
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authors.lastname: Minx
authors.affiliation: McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108;
authors.forename: John
authors.initials: J
authors.lastname: Spieth
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil;
authors.forename: A Bernardo
authors.initials: AB
authors.lastname: Carvalho
authors.affiliation: Sección Genética Evolutiva, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay;
authors.forename: Francisco
authors.initials: F
authors.lastname: Panzera
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom;
authors.forename: Daniel
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authors.lastname: Lawson
authors.affiliation: Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, Brazil; Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil;
authors.forename: André Q
authors.initials: AQ
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authors.affiliation: Section of Vector Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;
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authors.initials: JM
authors.lastname: Ribeiro
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
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authors.initials: MH
authors.lastname: Sorgine
authors.affiliation: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva 1211, Switzerland; Swiss Institute of Bioinformatics, Geneva 1211, Switzerland; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139; The Broad Institute of MIT and Harvard, Cambridge, MA 02142;
authors.forename: Robert M
authors.initials: RM
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authors.affiliation: McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108;
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authors.identifier: http://orcid.org/0000-0003-0253-4404
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authors.affiliation: Grupo de Pesquisa em Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fundação Oswaldo Cruz, Amazonas 69057-070, Brazil;
authors.forename: Fernando
authors.initials: F
authors.lastname: Abad-Franch
authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
authors.forename: Michele
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authors.affiliation: Laboratório de Bioinformática e Análises Moleculares, Instituto de Genética e Bioquímica, Faculdade de Computação, Universidade Federal de Uberlândia, Minas Gerais 38700-002, Brazil;
authors.forename: Laurence R
authors.initials: LR
authors.lastname: Amaral
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
authors.forename: Helena M
authors.initials: HM
authors.lastname: Araujo
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Minas Gerais 31270-901, Brazil;
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authors.identifier: http://orcid.org/0000-0002-1272-4386
authors.initials: RN
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authors.affiliation: National Library of Medicine, National Center for Biotechnology Information, National Institutes of Health, Rockville, MD 20894;
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authors.lastname: Aravind
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
authors.forename: Georgia C
authors.initials: GC
authors.lastname: Atella
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil;
authors.forename: Patricia
authors.initials: P
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authors.affiliation: Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
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authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
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authors.initials: PR
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authors.affiliation: Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, Brazil; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil;
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authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
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authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
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authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
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authors.initials: IF
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authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
authors.forename: Felipe A
authors.initials: FA
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authors.affiliation: Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205-2179;
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authors.affiliation: Department of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN 46556;
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authors.affiliation: Centro Regional de Estudios Genomicos, Universidad Nacional de La Plata, La Plata 1900, Argentina;
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authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Núcleo de Pesquisas Ecológicas de Macaé, Universidade Federal do Rio de Janeiro, Rio de Janeiro 27910-970, Brazil;
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authors.initials: RN
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authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
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authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
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authors.initials: AC
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authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil;
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authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil;
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authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil;
authors.forename: Bruno
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authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
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authors.affiliation: Departamento de Biologia, Universidade Estadual Paulista, São José do Rio Preto, São Paulo 15054-000, Brazil;
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authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Minas Gerais 30190-002, Brazil;
authors.forename: Alessandra A
authors.initials: AA
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authors.affiliation: Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona 08003, Catalonia, Spain; Universitat Pompeu Fabra, Barcelona 08003, Catalonia, Spain;
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authors.affiliation: Laboratoire d'Evolution, Génome et Spéciation, Centre National de la Recherche Scientifique UPR9034/UR 072, Institut de Recherche pour le Développement, 91198 Gif sur Yvette, France; Université Paris-Sud, 91400 Orsay, France;
authors.forename: Myriam
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authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
authors.forename: Willy
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authors.affiliation: Instituto de Investigaciones Bioquímicas de La Plata, Facultad de Ciencias Médicas, Universidad Nacional de La Plata-CONICET, La Plata 1900, Argentina;
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authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil;
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authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Minas Gerais 30190-002, Brazil;
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authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil;
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authors.initials: CR
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authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
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authors.initials: RR
authors.lastname: Lopes
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Minas Gerais 30190-002, Brazil;
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authors.affiliation: Laboratório de Química e Função de Proteínas e Peptídeos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Rio de Janeiro 28013-602, Brazil;
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authors.initials: MD
authors.lastname: Lugon
authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil; Departamento de Biotecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil;
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authors.identifier: http://orcid.org/0000-0001-7916-5315
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authors.affiliation: Division of Parasitic Diseases and Malaria, Entomology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329;
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authors.affiliation: Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona 08003, Catalonia, Spain; Universitat Pompeu Fabra, Barcelona 08003, Catalonia, Spain;
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authors.lastname: Mariotti
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
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authors.initials: H
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authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom;
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authors.affiliation: Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, Brazil; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil;
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authors.identifier: http://orcid.org/0000-0003-0686-7089
authors.initials: AC
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authors.affiliation: Department of Physiology, Biophysics and Neuroscience, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Zacatenco, Mexico City 03760, Mexico;
authors.forename: Fanis
authors.initials: F
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authors.affiliation: Department of Biological Sciences, Florida International University, Miami, FL 11200;
authors.forename: Marcela
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authors.lastname: Nouzova
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
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authors.initials: RL
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authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
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authors.forename: Sheila
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authors.lastname: Ons
authors.affiliation: Department of Biology, University of Toronto, Mississauga, ON L5L 1C6.
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authors.affiliation: Centro Regional de Estudios Genomicos, Universidad Nacional de La Plata, La Plata 1900, Argentina;
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authors.lastname: Pagola
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
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authors.initials: GO
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authors.affiliation: Centro Regional de Estudios Genomicos, Universidad Nacional de La Plata, La Plata 1900, Argentina;
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authors.affiliation: Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil;
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authors.affiliation: Instituto de Investigaciones Bioquímicas de La Plata, Facultad de Ciencias Médicas, Universidad Nacional de La Plata-CONICET, La Plata 1900, Argentina;
authors.forename: Nicolás
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authors.lastname: Pedrini
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil;
authors.forename: Alexandre A
authors.initials: AA
authors.lastname: Peixoto
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Minas Gerais 31270-901, Brazil;
authors.forename: Marcos H
authors.initials: MH
authors.lastname: Pereira
authors.affiliation: Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205-2179;
authors.forename: Andrew
authors.initials: A
authors.lastname: Pike
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
authors.forename: Carla
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authors.lastname: Polycarpo
authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
authors.forename: Francisco
authors.initials: F
authors.lastname: Prosdocimi
authors.affiliation: Núcleo de Doenças Infecciosas, Universidade Federal do Espirito Santo, Espirito Santo 29043-900, Brazil;
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Ribeiro-Rodrigues
authors.affiliation: Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, IL 61801;
authors.forename: Hugh M
authors.initials: HM
authors.lastname: Robertson
authors.affiliation: Instituto Federal de Educação Ciência e Tecnologia do Rio de Janeiro, Rio de Janeiro 20270-021, Brazil;
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Salerno
authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
authors.forename: Didier
authors.initials: D
authors.lastname: Salmon
authors.affiliation: Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona 08003, Catalonia, Spain; Universitat Pompeu Fabra, Barcelona 08003, Catalonia, Spain;
authors.forename: Didac
authors.initials: D
authors.lastname: Santesmasses
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil;
authors.forename: Renata
authors.initials: R
authors.lastname: Schama
authors.affiliation: Instituto Federal de Educação Ciência e Tecnologia do Rio de Janeiro, Rio de Janeiro 20270-021, Brazil;
authors.forename: Eloy S
authors.initials: ES
authors.lastname: Seabra-Junior
authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
authors.forename: Livia
authors.initials: L
authors.lastname: Silva-Cardoso
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
authors.forename: Mario A C
authors.initials: MA
authors.lastname: Silva-Neto
authors.affiliation: Laboratório de Bioinformática e Análises Moleculares, Instituto de Genética e Bioquímica, Faculdade de Computação, Universidade Federal de Uberlândia, Minas Gerais 38700-002, Brazil;
authors.forename: Matheus
authors.initials: M
authors.lastname: Souza-Gomes
authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
authors.forename: Marcos
authors.initials: M
authors.lastname: Sterkel
authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
authors.forename: Mabel L
authors.initials: ML
authors.lastname: Taracena
authors.affiliation: Department of Physiology, School of Medicine-Center for Resesarch in Molecular Medicine and Chronic Diseases, Instituto de Investigaciones Sanitarias, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain;
authors.forename: Marta
authors.initials: M
authors.lastname: Tojo
authors.affiliation: Department of Biochemistry, Virginia Polytechnic Institute, Blacksburg, VA 24061;
authors.forename: Zhijian Jake
authors.initials: ZJ
authors.lastname: Tu
authors.affiliation: Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom; and.
authors.forename: Jose M C
authors.initials: JM
authors.lastname: Tubio
authors.affiliation: Biological Sciences, Simon Fraser University, Burnaby, BC, Canada V5A 1S6;
authors.forename: Raul
authors.initials: R
authors.lastname: Ursic-Bedoya
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Laboratório de Química e Função de Proteínas e Peptídeos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Rio de Janeiro 28013-602, Brazil;
authors.forename: Thiago M
authors.initials: TM
authors.lastname: Venancio
authors.affiliation: Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil;
authors.forename: Ana Beatriz
authors.initials: AB
authors.lastname: Walter-Nuno
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute, Welcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom;
authors.forename: Derek
authors.initials: D
authors.lastname: Wilson
authors.affiliation: McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108;
authors.forename: Wesley C
authors.initials: WC
authors.lastname: Warren
authors.affiliation: McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108;
authors.forename: Richard K
authors.initials: RK
authors.lastname: Wilson
authors.affiliation: Department of Biological Sciences, University of Manitoba, Winnipeg, MB, Canada R3T 2N2.
authors.forename: Erwin
authors.initials: E
authors.lastname: Huebner
authors.affiliation: Division of Parasitic Diseases and Malaria, Entomology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329; rdmesquita@iq.ufrj.br edotson@cdc.gov pedro@bioqmed.ufrj.br.
authors.forename: Ellen M
authors.initials: EM
authors.lastname: Dotson
authors.affiliation: Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro 21941-591, Brazil; Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-591, Brazil; rdmesquita@iq.ufrj.br edotson@cdc.gov pedro@bioqmed.ufrj.br.
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Oliveira
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D014355:Chagas Disease; D022761:Gene Transfer, Horizontal; D006790:Host-Parasite Interactions / Q000235:genetics*; D006801:Humans; D007303:Insect Vectors / Q000235:genetics / Q000469:parasitology; D008969:Molecular Sequence Data; D012239:Rhodnius / Q000235:genetics / Q000469:parasitology; D014349:Trypanosoma cruzi / Q000502:physiology*; D020577:Wolbachia / Q000235:genetics
keywords: Chagas disease; Rhodnius prolixus; genome; hematophagy; immunity