title: Emergency Room Treatment of Hypertensive Crises.
abstract: OBJECTIVE
  The aim of the study was to evaluate efficiency of hypertensive urgency treatment using inhibitors of α1-adrenergic receptors and angiotensin converting enzyme inhibitors-ACE inhibitors in the Emergency Room of Outpatient Hospital and Polyclinic "dr Mustafa Šehovic" Tuzla in relation to age, duration and severity of hypertension.
  
  
  METHODS
  The study was conducted from June 2011 to May 2012 and included 120 patients of both sexes diagnosed with arterial hypertension, aged 40 to 80 with verified hypertensive urgency. The patients were divided into two groups: the control group treated with sublingual captopril and the experimental group treated intravenously with urapidil.
  
  
  RESULTS
  The results show that the largest number of patients belonged to age group from 60 to 69 years (34,16%), and the average age was 58 (11). The largest number of patients (38,0%) had verified hypertension for 11 to 20 years. The average systolic/diastolic artery blood pressure at reception was 213 (19) / 130 (4) mmHg. The average systolic/diastolic artery blood pressure after the first dose of 12,5 mg captopril in the control group was 177,42 (10,91) / 112,33 (3,50) mmHg, while after the first dose of 12,5 mg urapidil it was 179,25 (16,62) / 110,33 (8,78) mmHg. The average systolic/diastolic artery blood pressure after the second dose of 12,5 mg of captopril in the control group was 152,00 (6,32) / 95,50 (3,76) mmHg, while after the second dose of 12,5 mg of urapidil it was 152,55 (7,17) / 95,29 (5,04) mmHg.
  
  
  CONCLUSIONS
  Urapidil is more efficient in hypertensive urgency treatment, since the decrease of middle artery pressure (MAP) in the group treated with urapidil was statistically significant (p<0,001). No statistical significance was found between the efficiency of urapidil and the patient's age, while captopril was more efficient in older patients (p=0,02). Also, no statistically significant difference was found between the efficiency of captopril and urapidil in relation to duration of hypertension.
authors.affiliation: Emergency Medical Service Department, Community Health Care Center Tuzla.
authors.forename: Sabina
authors.initials: S
authors.lastname: Salkic
authors.affiliation: Department of Pathophysiology, Faculty of Medicine, University of Tuzla.
authors.forename: Selmira
authors.initials: S
authors.lastname: Brkic
authors.affiliation: Family Medicine Education Centre, Community Health Care Center Tuzla.
authors.forename: Olivera
authors.initials: O
authors.lastname: Batic-Mujanovic
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Tuzla.
authors.forename: Farid
authors.initials: F
authors.lastname: Ljuca
authors.affiliation: Public Health Institution Gradske apoteke Tuzla.
authors.forename: Almedina
authors.initials: A
authors.lastname: Karabasic
authors.affiliation: Biochemistry Institute, University Clinical Centre Tuzla.
authors.forename: Sehveta
authors.initials: S
authors.lastname: Mustafic
mesh_terms: D000208:Acute Disease; D061605:Administration, Intravenous; D000286:Administration, Sublingual; D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D017522:Bosnia and Herzegovina; D002216:Captopril / Q000008:administration & dosage / Q000627:therapeutic use*; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D010879:Piperazines; D002216:Captopril; C015568:urapidil
keywords: captopril; hypertensive crisis; urapidil