title: Application of metabolomics to toxicology of drugs of abuse: A mini review of metabolomics approach to acute and chronic toxicity studies.
abstract: Metabolomics has been widely applied to toxicological fields, especially to elucidate the mechanism of action of toxicity. In this review, metabolomics application with focus on the studies of chronic and acute toxicities of drugs of abuse like stimulants, opioids and the recently-distributed designer drugs will be presented in addition to an outline of basic analytical techniques used in metabolomics. Limitation of metabolomics studies and future perspectives will be also provided.
authors.affiliation: Department of Legal Medicine & Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; Institute for Advanced Research, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan. Electronic address: kzaitsu@med.nagoya-u.ac.jp.
authors.forename: Kei
authors.initials: K
authors.lastname: Zaitsu
authors.affiliation: Institute for Advanced Research, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan; Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya 461-8673, Japan. Electronic address: yhayashi@met.nagoya-u.ac.jp.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Hayashi
authors.affiliation: Department of Legal Medicine & Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address: maiko-k@med.nagoya-u.ac.jp.
authors.forename: Maiko
authors.initials: M
authors.lastname: Kusano
authors.affiliation: Department of Legal Medicine & Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address: tsuchi@med.nagoya-u.ac.jp.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tsuchihashi
authors.affiliation: Department of Legal Medicine & Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address: akishii@med.nagoya-u.ac.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Ishii
mesh_terms: D000818:Animals; D006801:Humans; D013287:Illicit Drugs / Q000633:toxicity*; D055432:Metabolomics; D019966:Substance-Related Disorders / Q000378:metabolism*
chemical_list: D013287:Illicit Drugs
keywords: Acute toxicity; Chronic toxicity; Drugs of abuse; Metabolomics; Toxicology