title: Invasive pleural malignant mesothelioma with rib destruction and concurrent osteosarcoma in a dog.
abstract: A 7-year-old Dachshund was clinically examined because of a 10-day history of lameness in the left hind limb. On the basis of radiological and cytological findings, an osteosarcoma of the left acetabular region was suspected. The dog underwent a hemipelvectomy and osteosarcoma was diagnosed by subsequent histopathological examination. An immovable subcutaneous mass was noted on the left chest wall during the physical examination and non-septic neutrophilic inflammation was diagnosed by cytology. Forty days later, the dog showed signs of respiratory distress with an in-diameter increase of the subcutaneous mass up to 4 cm. Thoracic radiography and ultrasonography revealed pleural effusion and a lytic process in the fourth left rib. Furthermore, ultrasound examination revealed a mixed echogenic mobile structure with a diameter of around 2 cm floating within the pleural fluid of the left hemithorax close to the pericardium. The dog underwent surgery for an en bloc resection of the subcutaneous mass together with the fourth rib and the parietal pleura. Moreover, the left altered lung lobe, corresponding to the mobile structure detected by ultrasound, was removed. Based on cytological, histopathological, and immunohistochemical examinations, an invasive epithelioid pleural malignant mesothelioma was diagnosed.
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Località Piano D'Accio, 64100, Teramo, Italy. mditommaso@unite.it.
authors.forename: Morena
authors.initials: M
authors.lastname: Di Tommaso
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Località Piano D'Accio, 64100, Teramo, Italy. frocconi@unite.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Rocconi
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Località Piano D'Accio, 64100, Teramo, Italy. gmarruchella@unite.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Marruchella
authors.affiliation: Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise "G. Caporale", Via Campo Boario, 64100, Teramo, Italy. a.dangelo@izs.it.
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: D'Angelo
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Località Piano D'Accio, 64100, Teramo, Italy. stefanomasci@hotmail.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Masci
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Località Piano D'Accio, 64100, Teramo, Italy. santoridomenico@hotmail.com.
authors.forename: Domenico
authors.initials: D
authors.lastname: Santori
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Località Piano D'Accio, 64100, Teramo, Italy. civitellacarla@gmail.com.
authors.forename: Carla
authors.initials: C
authors.lastname: Civitella
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Località Piano D'Accio, 64100, Teramo, Italy. aluciani@unite.it.
authors.forename: Alessia
authors.initials: A
authors.lastname: Luciani
authors.affiliation: Faculty of Veterinary Medicine, University of Teramo, Località Piano D'Accio, 64100, Teramo, Italy. aboari@unite.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Boari
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004285:Dogs; D008168:Lung / Q000473:pathology / Q000601:surgery; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary*; D008297:Male; D008654:Mesothelioma / Q000150:complications / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary*; D000086002:Mesothelioma, Malignant; D012516:Osteosarcoma / Q000150:complications / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D012272:Ribs / Q000473:pathology* / Q000601:surgery