title: T Lymphocyte Migration: An Action Movie Starring the Actin and Associated Actors.
abstract: The actin cytoskeleton is composed of a dynamic filament meshwork that builds the architecture of the cell to sustain its fundamental properties. This physical structure is characterized by a continuous remodeling, which allows cells to accomplish complex motility steps such as directed migration, crossing of biological barriers, and interaction with other cells. T lymphocytes excel in these motility steps to ensure their immune surveillance duties. In particular, actin cytoskeleton remodeling is a key to facilitate the journey of T lymphocytes through distinct tissue environments and to tune their stop and go behavior during the scanning of antigen-presenting cells. The molecular mechanisms controlling actin cytoskeleton remodeling during T lymphocyte motility have been only partially unraveled, since the function of many actin regulators has not yet been assessed in these cells. Our review aims to integrate the current knowledge into a comprehensive picture of how the actin cytoskeleton drives T lymphocyte migration. We will present the molecular actors that control actin cytoskeleton remodeling, as well as their role in the different T lymphocyte motile steps. We will also highlight which challenges remain to be addressed experimentally and which approaches appear promising to tackle them.
authors.affiliation: INSERM, UMR 1043, Centre de Physiopathologie de Toulouse Purpan , Toulouse , France ; Université Toulouse III Paul-Sabatier , Toulouse , France ; CNRS, UMR 5282 , Toulouse , France.
authors.forename: Loïc
authors.initials: L
authors.lastname: Dupré
authors.affiliation: INSERM, UMR 1043, Centre de Physiopathologie de Toulouse Purpan , Toulouse , France ; Université Toulouse III Paul-Sabatier , Toulouse , France ; CNRS, UMR 5282 , Toulouse , France.
authors.forename: Raïssa
authors.initials: R
authors.lastname: Houmadi
authors.affiliation: INSERM, UMR 1043, Centre de Physiopathologie de Toulouse Purpan , Toulouse , France ; Université Toulouse III Paul-Sabatier , Toulouse , France ; CNRS, UMR 5282 , Toulouse , France ; Master BIOTIN, Université Montpellier I , Montpellier , France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Tang
authors.affiliation: INSERM, UMR 1043, Centre de Physiopathologie de Toulouse Purpan , Toulouse , France ; Université Toulouse III Paul-Sabatier , Toulouse , France ; CNRS, UMR 5282 , Toulouse , France.
authors.forename: Javier
authors.initials: J
authors.lastname: Rey-Barroso
keywords: T lymphocytes; actin cytoskeleton; migration