title: Transcatheter closure of the left atrial appendage: initial experience with the WATCHMAN device.
abstract: BACKGROUND
  Atrial fibrillation (AF) is the most commonly encountered clinical arrhythmia, accounting for approximately one third of hospitalizations for cardiac rhythm disturbance. In patients with non-valvular AF, approximately 90% of thrombi are thought to arise from the left atrial appendage (LAA). Anticoagulation with warfarin has been the mainstay of therapy to reduce stroke risk in these patients; however, it is not without its complications including bleeding and drug interactions. Percutaneous left atrial appendage closure can be an alternative to warfarin treatment in patients with AF at high risk for thromboembolic events and/or bleeding complications.
  
  
  METHODS
  Patients with atrial fibrillation and CHADSVASc score ≥ 2, not eligible for anticoagulation, were submitted to left atrial appendage closure using the WATCHMAN device. The procedure was performed under general anaesthesia, and was guided by fluoroscopy and transoesophageal echocardiography.
  
  
  RESULTS
  Percutaneous LAA closure with the WATCHMAN device was performed in all patients. At 45-day follow-up no recurrent major adverse events and especially no thromboembolic events occurred.
  
  
  CONCLUSIONS
  Transcatheter closure of the LAA with the WATCHMAN device is generally safe and feasible. Long-term follow-up will further reveal the risk and benefits of this therapy.
authors.affiliation: Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China.
authors.forename: Jiandong
authors.initials: J
authors.lastname: Ding
authors.affiliation: Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China.
authors.forename: Xiuxia
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China.
authors.forename: Mingqiang
authors.initials: M
authors.lastname: Ao
authors.affiliation: Department of Cardiology, Zhongda Hospital & School of Clinical Medicine Southeast University Nanjing, China.
authors.forename: Genshan
authors.initials: G
authors.lastname: Ma
keywords: Atrial fibrillation; WATCHMAN device; left atrial appendage