title: Pericolactines A-C, a New Class of Diterpenoid Alkaloids with Unusual Tetracyclic Skeleton.
abstract: Fusicoccane diterpenoids usually possess a fused 5-8-5 tricyclic ring system, which are biogenetically generated from geranylgeranyl diphosphate (GGDP). In our report, three novel diterpenoid alkaloids with fusicoccane skeleton, pericolactines A-C (1-3), were isolated from Periconia sp.. Their structures with absolute configurations were determined by spectroscopic analyses and quantum chemical ECD calculation. Pericolactines A-C (1-3) are a new class of diterpenoid alkaloids with an unusual fused 5-5-8-5 tetracyclic ring system, which derive from a geranylgeranyl diphosphate (GGDP) and serine conjugated biosynthesis. They belong to the atypical diterpenoid alkaloids.
authors.affiliation: Institute of Traditional Chinese Medicine &Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Yue-Hua
authors.initials: YH
authors.lastname: Wu
authors.affiliation: Institute of Traditional Chinese Medicine &Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Chen
authors.affiliation: Institute of Traditional Chinese Medicine &Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Rong-Rong
authors.initials: RR
authors.lastname: He
authors.affiliation: Institute of Traditional Chinese Medicine &Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Chuan-Xi
authors.initials: CX
authors.lastname: Wang
authors.affiliation: Institute of Traditional Chinese Medicine &Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Hu
authors.affiliation: Institute of Traditional Chinese Medicine &Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Gao-Qian
authors.initials: GQ
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Liang-Dong
authors.initials: LD
authors.lastname: Guo
authors.affiliation: Institute of Traditional Chinese Medicine &Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
authors.affiliation: Institute of Traditional Chinese Medicine &Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
mesh_terms: D000470:Alkaloids / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D008011:Lichens / Q000502:physiology; D011106:Polyisoprenyl Phosphates / Q000378:metabolism; D004718:Saccharomycetales / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D012694:Serine / Q000378:metabolism
chemical_list: D000470:Alkaloids; D004224:Diterpenes; D011106:Polyisoprenyl Phosphates; D012694:Serine; C002963:geranylgeranyl pyrophosphate