title: Reduced activity in functional networks during reward processing is modulated by abstinence in cocaine addicts.
abstract: Cocaine addiction is characterized by alterations in motivational and cognitive processes. Recent studies have shown that some alterations present in cocaine users may be related to the activity of large functional networks. The aim of this study was to investigate how these functional networks are modulated by non-drug rewarding stimuli in cocaine-dependent individuals. Twenty abstinent cocaine-dependent and 21 healthy matched male controls viewed erotic and neutral pictures while undergoing a functional magnetic resonance imaging scan. Group independent component analysis was then performed in order to investigate how functional networks were modulated by reward in cocaine addicts. The results showed that cocaine addicts, compared with healthy controls, displayed diminished modulation of the left frontoparietal network in response to erotic pictures, specifically when they were unpredicted. Additionally, a positive correlation between the length of cocaine abstinence and the modulation of the left frontoparietal network by unpredicted erotic images was found. In agreement with current addiction models, our results suggest that cocaine addiction contributes to reduce sensitivity to rewarding stimuli and that abstinence may mitigate this effect.
authors.affiliation: Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castellón, Spain.
authors.forename: Víctor
authors.initials: V
authors.lastname: Costumero
authors.affiliation: Departamento de Psicología y Sociología, Universidad de Zaragoza, Zaragoza, Spain.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Bustamante
authors.affiliation: Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castellón, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Rosell-Negre
authors.affiliation: Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castellón, Spain.
authors.forename: Paola
authors.initials: P
authors.lastname: Fuentes
authors.affiliation: Addictive Behaviors Unit San Agustín, Castellón, Spain.
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Llopis
authors.affiliation: Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castellón, Spain.
authors.forename: César
authors.initials: C
authors.lastname: Ávila
authors.affiliation: Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castellón, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Barrós-Loscertales
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology; D016022:Case-Control Studies; D019970:Cocaine-Related Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005625:Frontal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D010296:Parietal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012201:Reward
keywords: Abstinence; cocaine; frontoparietal network