title: First detection of autochthonous Zika virus transmission in a HIV-infected patient in Rio de Janeiro, Brazil.
abstract: Since May 2015, Brazil's Ministry of Health has reported autochthonous transmission of Zika virus (ZIKV) in some states of the country. Simultaneous circulation of Dengue, Chikungunya and ZIKV in the country hinder both the diagnosis and the therapeutic approach of patients seeking care with acute febrile illnesses especially in patients with comorbidities. The association between HIV infection and endemic diseases has been described especially in tropical regions with varying levels of complications, although there has been no report of ZIKV in HIV-infected patients. We report the first autochthonous case of laboratory confirmed ZIKV infection in a HIV-infected patient in Rio de Janeiro, Brazil. He evolved with only mild symptoms and recovered well without major laboratory abnormalities. Phylogenetic analysis of the ZIKV detected in the patient sera clustered within the Asian clade. To the best of our knowledge, this is the first time that Zika virus co-infection is reported in a HIV-infected patient.
authors.affiliation: Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: guilherme.calvet@ini.fiocruz.br.
authors.forename: Guilherme A
authors.initials: GA
authors.lastname: Calvet
authors.affiliation: Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: abispo@ioc.fiocruz.br.
authors.forename: Ana Maria B
authors.initials: AM
authors.lastname: Filippis
authors.affiliation: Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: marcosclm@ioc.fiocruz.br.
authors.forename: Marcos Cesar L
authors.initials: MC
authors.lastname: Mendonça
authors.affiliation: Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: patricia@ioc.fiocruz.br.
authors.forename: Patricia C
authors.initials: PC
authors.lastname: Sequeira
authors.affiliation: Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: andre.siqueira@ini.fiocruz.br.
authors.forename: Andre M
authors.initials: AM
authors.lastname: Siqueira
authors.affiliation: STD/AIDS Clinical Research Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: valdilea.veloso@gmail.com.
authors.forename: Valdilea G
authors.initials: VG
authors.lastname: Veloso
authors.affiliation: Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: rita@ioc.fiocruz.br.
authors.forename: Rita M
authors.initials: RM
authors.lastname: Nogueira
authors.affiliation: Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Av Brasil 4365, Manguinhos, Rio de Janeiro, Rio de Janeiro 21045-360, Brazil. Electronic address: patricia.brasil@ini.fiocruz.br.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Brasil
mesh_terms: D000328:Adult; D001938:Brazil; D016000:Cluster Analysis; D005838:Genotype; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D010802:Phylogeny; D000071244:Zika Virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D000071243:Zika Virus Infection / Q000175:diagnosis* / Q000821:virology
keywords: Arbovirus; Brazil; HIV; ZIKV; Zika