title: Flower-like PEGylated MoS2 nanoflakes for near-infrared photothermal cancer therapy.
abstract: Photothermal cancer therapy has attracted considerable interest for cancer treatment in recent years, but the effective photothermal agents remain to be explored before this strategy can be applied clinically. In this study, we therefore develop flower-like molybdenum disulfide (MoS2) nanoflakes and investigate their potential for photothermal ablation of cancer cells. MoS2 nanoflakes are synthesized via a facile hydrothermal method and then modified with lipoic acid-terminated polyethylene glycol (LA-PEG), endowing the obtained nanoflakes with high colloidal stability and very low cytotoxicity. Upon irradiation with near infrared (NIR) laser at 808 nm, the nanoflakes showed powerful ability of inducing higher temperature, good photothermal stability and high photothermal conversion efficiency. The in vitro photothermal effects of MoS2-PEG nanoflakes with different concentrations were also evaluated under various power densities of NIR 808-nm laser irradiation, and the results indicated that an effective photothermal killing of cancer cells could be achieved by a low concentration of nanoflakes under a low power NIR 808-nm laser irradiation. Furthermore, cancer cell in vivo could be efficiently destroyed via the photothermal effect of MoS2-PEG nanoflakes under the irradiation. These results thus suggest that the MoS2-PEG nanoflakes would be as promising photothermal agents for future photothermal cancer therapy.
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Feng
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Qin
authors.affiliation: College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhou
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
authors.forename: Yingke
authors.initials: Y
authors.lastname: Miao
authors.affiliation: College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
authors.forename: Kexin
authors.initials: K
authors.lastname: Qiu
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
authors.forename: Yanzhong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
authors.forename: Chuanglong
authors.initials: C
authors.lastname: He
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects / Q000528:radiation effects; D045744:Cell Line, Tumor; D003599:Cytoskeleton / Q000187:drug effects / Q000528:radiation effects; D004220:Disulfides / Q000737:chemistry* / Q000633:toxicity; D005260:Female; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D007834:Lasers; D008247:Lysosomes / Q000187:drug effects / Q000528:radiation effects; D008422:Materials Testing; D008807:Mice, Inbred BALB C; D008982:Molybdenum / Q000737:chemistry* / Q000633:toxicity; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D010789:Phototherapy / Q000379:methods*; D011092:Polyethylene Glycols; D023041:Xenograft Model Antitumor Assays
chemical_list: D004220:Disulfides; D011092:Polyethylene Glycols; D008982:Molybdenum; C082964:molybdenum disulfide