title: Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents.
abstract: Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juvenile delinquents from Northern Russia (n = 180), the polymorphism at -1021 was associated neither with early-onset CD nor with psychopathic traits. Association was found between psychopathic traits and early-onset CD, ADHD and mania.
authors.affiliation: Department of Neuroscience, Uppsala University, Uppsala, Sweden. johan.isaksson@neuro.uu.se.
authors.forename: Johan
authors.initials: J
authors.lastname: Isaksson
authors.affiliation: Child Study Center, Yale University, New Haven, CT, USA.|Moscow State University, Moscow, Russia.
authors.forename: Elena L
authors.initials: EL
authors.lastname: Grigorenko
authors.affiliation: Department of Neuroscience, Uppsala University, Uppsala, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Oreland
authors.affiliation: Stockholm University, Stockholm, Sweden.|Karolinska Institutet, Stockholm, Sweden.
authors.forename: Britt
authors.initials: B
authors.lastname: Af Klinteberg
authors.affiliation: University of Tromsø, Tromsø, Norway.
authors.forename: Roman A
authors.initials: RA
authors.lastname: Koposov
authors.affiliation: Department of Neuroscience, Uppsala University, Uppsala, Sweden.|Child Study Center, Yale University, New Haven, CT, USA.|Säter Forensic Psychiatric Clinic, Säter, Sweden.
authors.forename: Vladislav
authors.initials: V
authors.lastname: Ruchkin
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D000987:Antisocial Personality Disorder / Q000235:genetics*; D019955:Conduct Disorder / Q000235:genetics*; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007604:Juvenile Delinquency / Q000523:psychology*; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012426:Russia
chemical_list: D004299:Dopamine beta-Hydroxylase
keywords: Conduct disorder; DβH; Genetic; Psychopathy