title: Intake of Meals Containing High Levels of Carbohydrates or High Levels of Unsaturated Fatty Acids Induces Postprandial Dysmetabolism in Young Overweight/Obese Men.
abstract: Postprandial metabolic response depends on the meals' components and can be different in normal weight and obese people. However, there are some discrepancies between various reports. The aim of this study was to determine the metabolic response after intake of standardised meals with various fat and carbohydrate contents and to determine the differences among normal weight and overweight/obese individuals. The study group comprised 46 healthy men. The participants were divided into two groups and study was carried out using a crossover method. Group I received high- and normal-carbohydrate meals, whereas group II received high-carbohydrate and high-fat meals. Glucose, insulin, triglyceride, and free fatty acids levels were measured at fasting state and at 30, 60, 120, 180, and 240 minutes after meal intake. Despite the lack of differences in glucose levels, insulin levels were higher among overweight/obese individuals after each meal. TG and FFA levels were higher after normal-carbohydrate and high-fat meals. Moreover, in overweight/obese young men after high-fat meal intake postprandial hypertriglyceridemia was observed, even if meals contained predominantly unsaturated fatty acids, and fasting triglycerides levels were in normal range. The conducted study showed that postprandial metabolic response depends not only on the meal macronutrient content but also on the current body mass index (BMI).
authors.affiliation: Clinical Research Centre, Medical University of Bialystok, M.C. Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland.
authors.forename: Edyta
authors.initials: E
authors.lastname: Adamska
authors.affiliation: Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, Mieszka I-go 4B, 15-054 Bialystok, Poland.
authors.forename: Lucyna
authors.initials: L
authors.lastname: Ostrowska
authors.affiliation: Centre for Experimental Medicine, Medical University of Bialystok, M.C. Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Gościk
authors.affiliation: Clinical Research Centre, Medical University of Bialystok, M.C. Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland ; Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, Mieszka I-go 4B, 15-054 Bialystok, Poland ; Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M.C. Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Waszczeniuk
authors.affiliation: Clinical Research Centre, Medical University of Bialystok, M.C. Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland ; Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M.C. Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Krętowski
authors.affiliation: Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M.C. Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Górska
mesh_terms: D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D004040:Dietary Carbohydrates / Q000009:adverse effects*; D004041:Dietary Fats / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology; D005231:Fatty Acids, Unsaturated / Q000009:adverse effects*; D006801:Humans; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism / Q000502:physiology; D008297:Male; D062407:Meals / Q000502:physiology*; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D050177:Overweight / Q000378:metabolism*; D019518:Postprandial Period / Q000502:physiology*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D007328:Insulin; D014280:Triglycerides