title: [Use of direct oral anticoagulants in the elderly].
abstract: Equal safety and efficacy of direct oral anticoagulants as compared to vitamin K antagonists have been shown in elderly and very old patients. The use of these seem to have certain advantages in this special patient cohort: higher drug safety, no need for lab monitoring, less drug-drug interactions and a lower rate of intracranial hemorrhages. However, more data is needed to quantify the exact bleeding risk for geriatric patients. Elderly patients suffer quite frequently from significant comorbidities, such as renal failure, dementia, vision loss etc., which might put them at higher risk to suffer from medication side effects, especially bleeding complications. Routine clinical examinations combined with monitoring of renal function are therefore of paramount importance. Regarding these precautions the use of the new oral anticoagulants in the elderly is hence quite justified and rising.
authors.affiliation: Klinik für Akutgeriatrie, Klinikum St. Georg gGmbH, Leipzig.
authors.forename: Frank
authors.initials: F
authors.lastname: Mickley
authors.affiliation: Klinik für Akutgeriatrie, Klinikum St. Georg gGmbH, Leipzig.
authors.forename: Grit
authors.initials: G
authors.lastname: Geigenmüller
authors.affiliation: Klinik für Akutgeriatrie, Klinikum St. Georg gGmbH, Leipzig.
authors.forename: Claudia
authors.initials: C
authors.lastname: Schinköthe
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects*; D015331:Cohort Studies; D015897:Comorbidity; D004347:Drug Interactions; D005858:Germany; D006470:Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D018570:Risk Assessment; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D000925:Anticoagulants; D014812:Vitamin K