title: Comparison of the Clinical Manifestations between Acute Vogt-Koyanagi-Harada Disease and Acute Bilateral Central Serous Chorioretinopathy.
abstract: OBJECTIVE
  To compare clinical, angiographic, and optical coherence tomographic characteristics between eyes with acute Vogt-Koyanagi-Harada (VKH) disease and eyes with acute bilateral central serous chorioretinopathy (CSC), and to demonstrate distinguishing features between the two diseases in confusing cases.
  
  
  METHODS
  The medical records of 35 patients with VKH disease and 25 patients with bilateral CSC were retrospectively reviewed. Characteristics according to slit-lamp biomicroscopy, ophthalmoscopy, fundus photography, fluorescein angiography, indocyanine green angiography, and spectral-domain optical coherence tomography were compared between the two diseases.
  
  
  RESULTS
  Five of 35 patients (10 of 70 eyes, 14.3%) with VKH disease were initially misdiagnosed as CSC patients, and six of 25 patients (12 of 50 eyes, 24%) with bilateral CSC were initially misdiagnosed as patients with VKH disease. Pigment epithelial detachment in CSC and optic disc hyperemia in VKH disease show the highest positive predictive values of 100% for each disease.
  
  
  CONCLUSIONS
  Optic disc hyperemia in VKH disease and pigment epithelial detachment in bilateral CSC are the most specific clinical manifestations of each disease at initial patient presentation.
authors.affiliation: Department of Ophthalmology, Institute of Vision Research, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. ; Siloam Eye Hospital, Seoul, Korea.
authors.forename: Woo Beom
authors.initials: WB
authors.lastname: Shin
authors.affiliation: Department of Ophthalmology, Institute of Vision Research, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. ; Siloam Eye Hospital, Seoul, Korea.
authors.forename: Min Kyo
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Institute of Vision Research, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Christopher Seungkyu
authors.initials: CS
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Institute of Vision Research, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sung Chul
authors.initials: SC
authors.lastname: Lee
authors.affiliation: Siloam Eye Hospital, Seoul, Korea.
authors.forename: Hyesun
authors.initials: H
authors.lastname: Kim
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D056833:Central Serous Chorioretinopathy / Q000000981:diagnostic imaging*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D006940:Hyperemia / Q000175:diagnosis; D007208:Indocyanine Green / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000098:blood supply; D010781:Photography; D012163:Retinal Detachment / Q000175:diagnosis; D055213:Retinal Pigment Epithelium / Q000473:pathology; D012189:Retrospective Studies; D000072776:Slit Lamp Microscopy; D041623:Tomography, Optical Coherence; D014607:Uveomeningoencephalitic Syndrome / Q000000981:diagnostic imaging*; D055815:Young Adult
chemical_list: D007208:Indocyanine Green
keywords: Central serous chorioretinopathy; Fluorescein angiography; Indocyanine green angiography; Optical coherence tomography; Vogt-Koyanagi-Harada disease