title: Different Pathways to the Lysosome: Sorting out Alternatives.
abstract: Considerable research supports a model in which hydrolytic enzymes of mammalian lysosomes are sorted to their destinations in a receptor-dependent mechanism. The ligand for the mammalian sorting receptors is mannose 6-phosphate (M6P). Two M6P receptors have been defined in mammals. Here, we review the foundational evidence supporting this mechanism and highlight the remaining gaps in our understanding of the mammalian mechanism, including evidence for M6P-independent sorting, and its relevance to lysosomal enzyme sorting in metazoa.
authors.affiliation: Edward A. Doisy Department of Biochemistry and Molecular Biology, Doisy Research Center, Saint Louis University School of Medicine, St Louis, MO, USA.
authors.forename: Medina
authors.initials: M
authors.lastname: Hasanagic
authors.affiliation: Edward A. Doisy Department of Biochemistry and Molecular Biology, Doisy Research Center, Saint Louis University School of Medicine, St Louis, MO, USA.
authors.forename: Abdul
authors.initials: A
authors.lastname: Waheed
authors.affiliation: Edward A. Doisy Department of Biochemistry and Molecular Biology, Doisy Research Center, Saint Louis University School of Medicine, St Louis, MO, USA.
authors.forename: Joel C
authors.initials: JC
authors.lastname: Eissenberg
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D008247:Lysosomes / Q000201:enzymology / Q000378:metabolism*; D008360:Mannosephosphates / Q000378:metabolism; D008969:Molecular Sequence Data; D021381:Protein Transport; D017527:Receptor, IGF Type 2 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D008360:Mannosephosphates; D017527:Receptor, IGF Type 2; C027693:mannose-6-phosphate
keywords: Enzyme receptor; Lysosome; MPR 300; MPR 46; Mannose 6-phosphate