title: Trefoil factor 1 elevates the malignant phenotype of mucinous ovarian cancer cell through Wnt/β-catenin signaling.
abstract: Mucinous ovarian cancer accounts for almost 10% of epithelial ovarian cancer, though patients in the early stage have an excellent prognosis, patients with advanced disease have a poor outcome and the molecular mechanism remains unclear. In this study, we retrieved database and found a secretory protein TFF1, which plays a tumor suppressor role in gastric cancer, is highly expressed in mucinous ovarian cancer, not serous or any other kind of ovarian cancer. Furthermore, the highly expressed TFF1 indicates a poor clinical outcome. Further biological function analysis revealed that TFF1 not only promotes cell proliferation but also invasion and chemoresistance, and these oncogenic effects might through regulating the activity of Wnt/β-catenin signaling and the level of Twist. Taken together, we found TFF1 plays an oncogenic role in mucinous ovarian cancer, unlike its suppressive role in gastric cancer.
authors.affiliation: Department of Medical Oncology, The Second Hospital of Hebei Medical University China.
authors.forename: Shan
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Pathology, The Second Hospital of Hebei Medical University China.
authors.forename: Yumei
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University China.
authors.forename: Xianghua
authors.initials: X
authors.lastname: Huang
mesh_terms: D015153:Blotting, Western; D045744:Cell Line, Tumor; D002470:Cell Survival; D018282:Cystadenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D010641:Phenotype; D034741:RNA, Small Interfering; D060888:Real-Time Polymerase Chain Reaction; D014162:Transfection; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000502:physiology*
chemical_list: D034741:RNA, Small Interfering; C051838:TFF1 protein, human; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins
keywords: Trefoil Factor 1; Wnt/β-catenin signaling; cell invasion; cell proliferation; chemoresistance; mucinous ovarian cancer