title: Experimental study of influence of direct bisphosphonate administration on bone substitute.
abstract: Articular cartilage has a low self-repair ability and natural healing cannot be expected. Treatment using various bone substitutes has been performed, but these have various disadvantages. Compared to autologous bone substitutes, the osteochondral repair ability of allogeneic bone substitutes is low, but the effective and safe utilization of these as a bone substitute may be possible by improving their osteochondral repair ability. We prepared a full-thickness osteochondral defect in the patellar fossa of rabbits, added a bisphosphonate preparation to bovine tooth-derived Demineralized Dentin Matrix (DDM), which has its own osteochondral repair ability, and investigated osteochondral repair ability in the defects. As a result, we suggest that the addition of high-dose BPs inhibits the osteochondral repair ability of DDM.
authors.affiliation: Department of Orthodontics, School of Dentistry, Aichi-Gakuin University.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yasuda
authors.forename: Ken
authors.initials: K
authors.lastname: Miyazawa
authors.forename: Takuma
authors.initials: T
authors.lastname: Sato
authors.forename: Keisuke
authors.initials: K
authors.lastname: Yagihashi
authors.forename: Shigemi
authors.initials: S
authors.lastname: Goto
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000494:pharmacology*; D002357:Cartilage Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002358:Cartilage, Articular; D003804:Dentin; D004164:Diphosphonates / Q000633:toxicity*; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D010329:Patella / Q000000981:diagnostic imaging / Q000601:surgery*; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects; D055114:X-Ray Microtomography
chemical_list: D018786:Bone Substitutes; C093073:Demineralized Dentin Matrix; D004164:Diphosphonates