title: Kaposi sarcoma in HIV-seronegative children presenting to the paediatric oncology ward in The Queen Elizabeth Central Hospital, Blantyre, Malawi during 2002-2014.
abstract: One of the most common malignancies in HIV-endemic, resource-poor countries is Kaposi sarcoma (KS). It is an AIDS-defining disease and as Malawi's incidence and prevalence of HIV is high, KS is now the most common cancer in adult male Malawians and the second most common in women and children. Most attention has focused on HIV-seropositive adults as their number far outweighs those of children. This audit concerns the presentation and outcome of HIV-seronegative children with KS who presented in a 12-year period (2002-2014) to The Queen Elizabeth Central Hospital. Twenty (10.5%) of the 191 children with KS presenting to the paediatric oncology ward during 2002-2014 were HIV-seronegative. They were usually younger than seropositive children and 62% had severe anaemia. The main presenting complaints in the HIV-seronegative group were woody oedema, commonly of a limb, and lymphadenopathy. Woody oedema was common in children with or without HIV infection. Seronegative children with KS were less likely to have oral KS than HIV infected children. Of 11 children who completed courses of chemotherapy, seven (63%) had complete cure sustained over a 1-year follow-up period. KS is potentially curable in this group of children. Chemotherapy regimens are equally effective in HIV-seropositive and HIV-seronegative children. The presentation of HIV-seronegative children with KS differs from adults and HIV-seropositive children. Further research is necessary to determine possible triggers for developing KS in HIV-seronegative children.
authors.affiliation: Medical Director, Queen Elizabeth Central Hospital, Blantyre, Malawi German Red Cross, Amrum, Germany kirstinmittermayer@gmail.com.
authors.forename: Kirstin
authors.initials: K
authors.lastname: Mittermayer-Vassallo
authors.affiliation: Clinical Officer, Queen Elizabeth Central Hospital, Blantyre, Malawi.
authors.forename: Kondwani
authors.initials: K
authors.lastname: Banda
authors.affiliation: Consultant Paediatrician, College of Medicine, Blantyre, Malawi.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Molyneux
mesh_terms: D000740:Anemia / Q000453:epidemiology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004487:Edema / Q000453:epidemiology; D005260:Female; D018023:HIV Seronegativity; D006801:Humans; D015994:Incidence; D000072281:Lymphadenopathy / Q000453:epidemiology; D008295:Malawi / Q000453:epidemiology; D008297:Male; D009752:Nutritional Status; D015995:Prevalence; D012189:Retrospective Studies; D012514:Sarcoma, Kaposi / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D016896:Treatment Outcome
keywords: HIV-seronegative; Kaposi sarcoma (KS); Malawi; children