title: Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy.
abstract: BACKGROUND
  Dilated cardiomyopathy (DCM) is the most common cardiomyopathy in children. MicroRNAs (miRNA) are small RNAs which have regulatory functions in many biological processes.
  
  
  OBJECTIVE
  We aimed to determine miRNA expression levels in plasma of children with DCM.
  
  
  METHODS
  Plasma expression levels of 379 miRNAs were compared between 23 DCM and 26 healthy children.
  
  
  RESULTS
  The expression levels of miR-618, miR-875-3p, miR-205, miR-194, miR-302a, miR-147, and miR-544 were found decreased. The expression levels of miR-518f and miR-454 were found increased in DCM patients.
  
  
  CONCLUSIONS
  miRNA level differences may provide the chance of using these miRNAs as new biomarkers.
authors.affiliation: a Department of Pediatrics , University of Gaziantep , Gaziantep , Turkey .
authors.forename: Mehmet
authors.initials: M
authors.lastname: Enes Coşkun
authors.affiliation: b Department of Pediatrics , Pediatric Cardiology Division, University of Gaziantep , Gaziantep , Turkey .
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kervancıoğlu
authors.affiliation: c Department of Medical Genetics , and.
authors.forename: Serdar
authors.initials: S
authors.lastname: Öztuzcu
authors.affiliation: d Department of Cardiology , University of Gaziantep , Gaziantep , Turkey , and.
authors.forename: Fatma
authors.initials: F
authors.lastname: Yılmaz Coşkun
authors.affiliation: c Department of Medical Genetics , and.
authors.forename: Sercan
authors.initials: S
authors.lastname: Ergün
authors.affiliation: b Department of Pediatrics , Pediatric Cardiology Division, University of Gaziantep , Gaziantep , Turkey .
authors.forename: Osman
authors.initials: O
authors.lastname: Başpınar
authors.affiliation: a Department of Pediatrics , University of Gaziantep , Gaziantep , Turkey .
authors.forename: Metin
authors.initials: M
authors.lastname: Kılınç
authors.affiliation: e Department of Pediatrics , Division of Pediatric Intensive Care, İstanbul University , İstanbul , Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Temel
authors.affiliation: a Department of Pediatrics , University of Gaziantep , Gaziantep , Turkey .
authors.forename: Mehmet Yavuz
authors.initials: MY
authors.lastname: Coşkun
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002311:Cardiomyopathy, Dilated / Q000097:blood* / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D020869:Gene Expression Profiling; D006801:Humans; D007223:Infant; D035683:MicroRNAs / Q000097:blood; D059467:Transcriptome
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: Children; dilated cardiomyopathy; microRNA