title: Evaluation of magnetic nanoparticles coated by 5-fluorouracil imprinted polymer for controlled drug delivery in mouse breast cancer model.
abstract: Nanoparticles (NPs) have been extensively investigated to improve delivery efficiency of therapeutic and diagnostic agents. In this study, magnetic molecularly imprinted polymer (MIP) was synthesized by using polydopamine. Synthesized MIP was used for controlled 5-fluorouracil (5-FU) delivery in a spontaneous model of breast adenocarcinoma in Balb/c mice in the presence of an external magnetic field. Antitumor effectiveness of 5-FU imprinted polymer (5-FU-IP) was evaluated in terms of tumor-growth delay, tumor-doubling time, inhibition ratio, and histopathology. Results showed higher efficacy of 5-FU-IP in the presence of magnetic field upon suppressing tumor growth than free 5-FU and 5-FU-IP without magnetic field. The 5-FU and Fe distribution among tissues were evaluated by high-performance liquid chromatography and flame atomic absorption spectrometry, respectively. The obtained results, showed significantly deposition of 5-FU in the 5-FU-IP treated group with magnetic field. Thus, magnetic 5-FU-IP is promising for breast cancer therapy with high efficacy.
authors.affiliation: Department of Chemistry, Damghan Branch, Islamic Azad University, Damghan, Iran. Electronic address: hashemimoghaddam@yahoo.com.
authors.forename: Hamid
authors.initials: H
authors.lastname: Hashemi-Moghaddam
authors.affiliation: Department of Chemistry, Damghan Branch, Islamic Azad University, Damghan, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Kazemi-Bagsangani
authors.affiliation: Department of Biochemistry, Damghan Branch, Islamic Azad University, Damghan, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Jamili
authors.affiliation: School of Biology, Damghan University, Damghan, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Zavareh
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D007211:Indoles / Q000737:chemistry; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D016019:Survival Analysis; D014018:Tissue Distribution
chemical_list: D000964:Antimetabolites, Antineoplastic; D007211:Indoles; D058185:Magnetite Nanoparticles; D011108:Polymers; C568283:polydopamine; D005472:Fluorouracil
keywords: 5-Fluorouracil; Imprinted polymer; Magnetic nanoparticles; Polydopamine