title: Percutaneous Closure of Intracardiac Defects in Adults: State of the Art.
abstract: The number of adults with congenital heart disease is expected to increase over the next decade. Although acquired defects are being increasingly recognized in adults, congenital heart disease remains the most common etiology. With advances in cardiac imaging, device technology, and transcatheter techniques, percutaneous closure is now feasible and safe for most intracardiac defects. Device closure is considered the first-line therapy for a variety of congenital intracardiac defects, including ostium secundum atrial septal defects and muscular ventricular septal defects. Percutaneous closure may prevent recurrent cerebrovascular events after a cryptogenic stroke in high-risk patients with patent foramen ovale. It is also an alternative therapeutic option for patients with acquired defects such as posttraumatic or postinfarction ventricular septal defects and paravalvular regurgitation associated with prosthetic valves. Complications after device closure are uncommon, and may be avoided with appropriate patient and device selection. This is a comprehensive review of the current transcatheter management of the most common intracardiac defects encountered in the adult population.
authors.forename: Andrés M
authors.initials: AM
authors.lastname: Pineda
authors.forename: Christos G
authors.initials: CG
authors.lastname: Mihos
authors.forename: Sandeep
authors.initials: S
authors.lastname: Singla
authors.forename: Orlando
authors.initials: O
authors.lastname: Santana
authors.forename: John
authors.initials: J
authors.lastname: Rhodes
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Sommer
authors.forename: Charanjit S
authors.initials: CS
authors.lastname: Rihal
authors.affiliation: Columbia University, Division of Cardiology Mount Sinai Heart Institute, 4300 Alton Road, Miami Beach, FL 33140 USA. Nirat.Beohar@msmc.com.
authors.forename: Nirat
authors.initials: N
authors.lastname: Beohar
mesh_terms: D000328:Adult; D006328:Cardiac Catheterization / Q000379:methods*; D017548:Echocardiography, Transesophageal; D054092:Foramen Ovale, Patent / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D055989:Septal Occluder Device; D020521:Stroke / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome