title: The Potential of High Resolution Magnetic Resonance Microscopy in the Pathologic Analysis of Resected Breast and Lymph Tissue.
abstract: Pathologic evaluation of breast specimens requires a fixation and staining procedure of at least 12 hours duration, delaying diagnosis and post-operative planning. Here we introduce an MRI technique with a custom-designed radiofrequency resonator for imaging breast and lymph tissue with sufficient spatial resolution and speed to guide pathologic interpretation and offer value in clinical decision making. In this study, we demonstrate the ability to image breast and lymphatic tissue using 7.0 Tesla MRI, achieving a spatial resolution of 59 × 59 × 94 μm(3) with a signal-to-noise ratio of 15-20, in an imaging time of 56 to 70 minutes. These are the first MR images to reveal characteristic pathologic features of both benign and malignant breast and lymph tissue, some of which were discernible by blinded pathologists who had no prior training in high resolution MRI interpretation.
authors.affiliation: Department of Radiology, Weill Cornell Medical College, Cornell University, New York, NY.
authors.forename: Brittany Z
authors.initials: BZ
authors.lastname: Dashevsky
authors.affiliation: Department of Pathology, Weill Cornell Medical College, Cornell University, New York, NY.
authors.forename: Timothy
authors.initials: T
authors.lastname: D'Alfonso
authors.affiliation: Department of Radiology, Memorial Sloan, Kettering Cancer Center, New York, NY.
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Sutton
authors.affiliation: Department of Healthcare Policy, Weill Cornell Medical College, Cornell University, New York, NY.
authors.forename: Ashley
authors.initials: A
authors.lastname: Giambrone
authors.affiliation: Department of Radiology, Weill Cornell Medical College, Cornell University, New York, NY.
authors.forename: Eric
authors.initials: E
authors.lastname: Aronowitz
authors.affiliation: Department of Pathology, Weill Cornell Medical College, Cornell University, New York, NY.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Morris
authors.affiliation: Department of Radiology, Weill Cornell Medical College, Cornell University, New York, NY.|Department of Radiology, Memorial Sloan, Kettering Cancer Center, New York, NY.
authors.forename: Krishna
authors.initials: K
authors.lastname: Juluru
authors.affiliation: Department of Physics, Weill Cornell Medical College, Cornell University, New York, NY.
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Ballon
mesh_terms: D001940:Breast / Q000473:pathology* / Q000601:surgery*; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008853:Microscopy / Q000379:methods*; D011795:Surveys and Questionnaires