title: Biotransformation of swertiamarin by Aspergillus niger.
abstract: The biotransforamtion of swertiamarin has been carried out using Aspergillus niger. The results showed that 60% swertiamarin were metabolized into two metabolites during the 5 days of biotransformation. The metabolites were identified as erythrocentaurin and 5-ethylidene-8-hydroxy-3,4,5,6,7,8-hexahydro-1Hpyrano[3,4-c]-pyridine-1-one, a novel alkaloid, with NMR and MS. The hydrolysis of glucosidic bond catalyzed by β-D-glucosidase was found to be the rate-limiting reaction in pathway of biotransformation of swertiamarin.
authors.affiliation: School of Science Life, Jiangxi Science & Technology Normal University, Nangchang, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chang
authors.affiliation: School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
mesh_terms: D001234:Aspergillus niger / Q000378:metabolism*; D001711:Biotransformation; D004365:Drugs, Chinese Herbal / Q000378:metabolism*; D006868:Hydrolysis; D057888:Iridoid Glucosides / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011753:Pyrones / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization; D013997:Time Factors
chemical_list: D004365:Drugs, Chinese Herbal; D057888:Iridoid Glucosides; D011753:Pyrones; C013270:swertiamarin