title: The Role of Dialysis Membranes on Intradialytic Selenium Removal and on Selenium Status in Patients Receiving Renal Replacement Therapy.
abstract: OBJECTIVE
  Dialysis membrane has been implicated in selenium (Se) deficiency in hemodialysis (HD). Intradialytic Se removal into dialysate through different membranes was investigated.
  
  
  METHODS
  We studied 19 patients on standard HD with low-flux polysulfone membrane (group A), 10 patients on standard HD with ethylene vinyl alcohol membrane (group B), 12 patients on hemodiafiltration (HDF; group C) and 16 healthy subjects (control group D). Se was measured in blood before and after dialysis session and in effluent dialysate every hour during session.
  
  
  RESULTS
  In all patients together, pre-dialysis serum Se levels were lower than those in control group, but, in a separate analysis, only in standard HD. In all patient groups, there was a net Se removal into dialysate but it was greater in HDF patients who, however, had similar pre-dialysis serum Se levels to those in healthy controls.
  
  
  CONCLUSIONS
  An intradialytic Se loss was found with all 3 membrane types, but it is not the principal factor for Se depletion in HD.
authors.affiliation: Nephrology Department, Konstantopoulion General Hospital, Athens, Greece.
authors.forename: Macroui
authors.initials: M
authors.lastname: Sonikian
authors.forename: Artemisia
authors.initials: A
authors.lastname: Dona
authors.forename: Jacob
authors.initials: J
authors.lastname: Skarakis
authors.forename: Sophia
authors.initials: S
authors.lastname: Trompouki
authors.forename: Theodora
authors.initials: T
authors.lastname: Miha
authors.forename: Ioannis
authors.initials: I
authors.lastname: Karatzas
authors.forename: Chara
authors.initials: C
authors.lastname: Spiliopoulou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001002:Anuria / Q000097:blood / Q000473:pathology / Q000628:therapy*; D016022:Case-Control Studies; D015314:Dialysis Solutions / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011108:Polymers / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry; D006435:Renal Dialysis / Q000295:instrumentation*; D012643:Selenium / Q000172:deficiency* / Q000302:isolation & purification; D013450:Sulfones / Q000737:chemistry
chemical_list: D015314:Dialysis Solutions; D008567:Membranes, Artificial; D011108:Polymers; D011145:Polyvinyls; D013450:Sulfones; C020320:ethylene-vinyl alcohol copolymer; C017662:polysulfone P 1700; D012643:Selenium