title: Low expression of KLF17 is associated with tumor invasion in esophageal carcinoma.
abstract: OBJECTIVE
  KLF17 belongs to the Sp/KLF zinc-finger protein family as a regulator in tumor development. However, its expression and biologic function has remained unclear in EC.
  
  
  METHODS
  The esophageal carcinoma tissue samples and adjacent normal tissues were obtained from the Second Hospital of Hebei Medical University. Immunohistochemistry, Western blot, and transfection were applied to evaluate the expression and clinical significance of KLF17 in esophageal cancer.
  
  
  RESULTS
  In this study, we showed that KLF17 was overexpressed in esophageal normal samples compared to the cancer. Moreover, KLF17 was upregulated at lymph node non-metastatic cancer tissues when compared to metastatic cancer tissues. KLF17 overexpression decreased EC cell proliferation, migration and invasion ability. In contrast, the knockdown of KLF17 increased EC cell proliferation, migration and invasion ability.
  
  
  CONCLUSIONS
  These results suggest that KLF17 inhibits tumor development and may serve as a potential therapeutic target.
authors.affiliation: Cancer Center, The Second Hospital of Hebei Medical University Shijiazhuang, China.
authors.forename: Shujun
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Hebei Chest Hospital Shijiazhuang, China.
authors.forename: Xuebo
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of Pathology, Hebei Chest Hospital Shijiazhuang, China.
authors.forename: Airong
authors.initials: A
authors.lastname: Cui
authors.affiliation: Department of Pathology, Hebei Chest Hospital Shijiazhuang, China.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Thoracic Surgery, Handan Central Hospital Handan, China.
authors.forename: Libing
authors.initials: L
authors.lastname: Ren
authors.affiliation: Cancer Center, The Second Hospital of Hebei Medical University Shijiazhuang, China.
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002277:Carcinoma / Q000235:genetics / Q000378:metabolism* / Q000556:secondary; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D002681:China; D015536:Down-Regulation; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006785:Hospitals, University; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D034622:RNA Interference; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014162:Transfection
chemical_list: D014408:Biomarkers, Tumor; C510638:KLF17 protein, human; D014157:Transcription Factors
keywords: Esophageal cancer; KLF17; invasion; migration