title: Multi-Toxic Endpoints of the Foodborne Mycotoxins in Nematode Caenorhabditis elegans.
abstract: Aflatoxins B₁ (AFB₁), deoxynivalenol (DON), fumonisin B₁ (FB₁), T-2 toxin (T-2), and zearalenone (ZEA) are the major foodborne mycotoxins of public health concerns. In the present study, the multiple toxic endpoints of these naturally-occurring mycotoxins were evaluated in Caenorhabditis elegans model for their lethality, toxic effects on growth and reproduction, as well as influence on lifespan. We found that the lethality endpoint was more sensitive for T-2 toxicity with the EC50 at 1.38 mg/L, the growth endpoint was relatively sensitive for AFB₁ toxic effects, and the reproduction endpoint was more sensitive for toxicities of AFB₁, FB₁, and ZEA. Moreover, the lifespan endpoint was sensitive to toxic effects of all five tested mycotoxins. Data obtained from this study may serve as an important contribution to knowledge on assessment of mycotoxin toxic effects, especially for assessing developmental and reproductive toxic effects, using the C. elegans model.
authors.affiliation: Synergetic Innovation Center of Food Safety and Nutrition, School of Food Science, Jiangnan University, Wuxi, Jiangsu 214122, China. zdyang777@163.com.|Department of Environmental Health Science, University of Georgia, Athens, GA 30602, USA. zdyang777@163.com.
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Environmental Health Science, University of Georgia, Athens, GA 30602, USA. ksxue@uga.edu.
authors.forename: Kathy S
authors.initials: KS
authors.lastname: Xue
authors.affiliation: Synergetic Innovation Center of Food Safety and Nutrition, School of Food Science, Jiangnan University, Wuxi, Jiangsu 214122, China. sxlzzz@jiangnan.edu.cn.
authors.forename: Xiulan
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Environmental Health Science, University of Georgia, Athens, GA 30602, USA. ltang@uga.edu.
authors.forename: Lili
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Environmental Health Science, University of Georgia, Athens, GA 30602, USA. jswang@uga.edu.
authors.forename: Jia-Sheng
authors.initials: JS
authors.lastname: Wang
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D005506:Food Contamination; D009183:Mycotoxins / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects
chemical_list: D009183:Mycotoxins
keywords: Caenorhabditis elegans; T-2 toxin; aflatoxin B1; deoxynivalenol; fumonisin B1; mycotoxins; zearalenone