title: Current standards of care and future directions for "high-risk" pediatric renal tumors: Anaplastic Wilms tumor and Rhabdoid tumor.
abstract: 'High risk' renal tumors of childhood generally includes anaplastic Wilms tumor, rhabdoid tumor, and metastatic renal sarcomas and carcinomas. In this review, the epidemiology, biology, treatment and prognosis of anaplastic Wilms tumor and rhabdoid tumor are presented. Future directions related to management of such cancers are discussed, with insights provided into possible clinical trials in development that consider integration of novel targeted therapies.
authors.affiliation: Division of Oncology, Cincinnati Children׳s Hospital Medical Center, University of Cincinnati, Cincinnati, OH. Electronic address: James.Geller@cchmc.org.
authors.forename: James I
authors.initials: JI
authors.lastname: Geller
mesh_terms: D002277:Carcinoma / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D002648:Child; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D018335:Rhabdoid Tumor / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D059039:Standard of Care; D009396:Wilms Tumor / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*
keywords: Anaplastic Wilms tumor; Pediatric renal cancer; Rhabdoid tumor; p53