title: Natural Products as Tools for Defining How Cellular Metabolism Influences Cellular Immune and Inflammatory Function during Chronic Infection.
abstract: Chronic viral infections like those caused by hepatitis C virus (HCV) and human immunodeficiency virus (HIV) cause disease that establishes an ongoing state of chronic inflammation. While there have been tremendous improvements towards curing HCV with directly acting antiviral agents (DAA) and keeping HIV viral loads below detection with antiretroviral therapy (ART), there is still a need to control inflammation in these diseases. Recent studies indicate that many natural products like curcumin, resveratrol and silymarin alter cellular metabolism and signal transduction pathways via enzymes such as adenosine monophosphate kinase (AMPK) and mechanistic target of rapamycin (mTOR), and these pathways directly influence cellular inflammatory status (such as NF-κB) and immune function. Natural products represent a vast toolkit to dissect and define how cellular metabolism controls cellular immune and inflammatory function.
authors.affiliation: Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA. elove@uw.edu.
authors.forename: Erica S
authors.initials: ES
authors.lastname: Lovelace
authors.affiliation: Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA. polyak@uw.edu.|Department of Microbiology, University of Washington, Seattle, WA 98195, USA. polyak@uw.edu.|Department of Global Health, University of Washington, Seattle, WA 98195, USA. polyak@uw.edu.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Polyak
mesh_terms: D001688:Biological Products / Q000494:pharmacology*; D002908:Chronic Disease; D003474:Curcumin / Q000494:pharmacology; D015658:HIV Infections / Q000473:pathology; D006526:Hepatitis C / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007155:Immunologic Factors / Q000494:pharmacology*; D007249:Inflammation / Q000473:pathology*; D000077185:Resveratrol; D012838:Silymarin / Q000494:pharmacology; D013267:Stilbenes / Q000494:pharmacology
chemical_list: D001688:Biological Products; D007155:Immunologic Factors; D012838:Silymarin; D013267:Stilbenes; D003474:Curcumin; D000077185:Resveratrol
keywords: AMPK; HCV; HIV; NF-κB; inflammation; mTOR; natural product