title: Predictors of health-related quality of life and participation after brain injury rehabilitation: The role of neuropsychological factors.
abstract: The aims of this longitudinal study were: (1) to assess associations between neuropsychological factors and health-related quality of life (HRQoL) and participation three months after discharge from inpatient acquired brain injury (ABI) rehabilitation; and (2) to determine the best neuropsychological predictor of HRQoL and participation after controlling for demographic and injury-related factors. Patients with ABI (n = 100) were assessed within approximately two weeks of enrolment in inpatient rehabilitation. Predictor variables included demographic and injury-related characteristics and the following neuropsychological factors: active and passive coping, attention, executive functioning, verbal memory, learning potential, depressive symptoms, motivation, extraversion, neuroticism and self-awareness. Bivariate analyses revealed that passive coping, executive functioning, depressive symptoms, extraversion, and neuroticism were significantly associated with HRQoL and/or participation. Neuropsychological factors significantly explained additional variance in HRQoL (18.1-21.6%) and participation (6.9-20.3%) after controlling for demographic and injury-related factors. However, a higher tendency towards passive coping was the only significant neuropsychological predictor (β = -0.305 to -0.464) of lower HRQoL and participation. This study shows that neuropsychological functioning, and in particular passive coping, plays a role in predicting HRQoL and participation after inpatient ABI rehabilitation and emphasises the importance of addressing patients' coping styles in an early phase of ABI rehabilitation.
authors.affiliation: a Brain Center Rudolf Magnus and Center of Excellence for Rehabilitation Medicine , University Medical Center Utrecht and De Hoogstraat Rehabilitation , Utrecht , The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Boosman
authors.affiliation: b Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience , Maastricht University , Maastricht , The Netherlands.
authors.forename: I
authors.initials: I
authors.lastname: Winkens
authors.affiliation: b Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience , Maastricht University , Maastricht , The Netherlands.|c Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience , Maastricht University , Maastricht , The Netherlands.
authors.forename: C M
authors.initials: CM
authors.lastname: van Heugten
authors.affiliation: d Adelante Centre of Expertise in Rehabilitation and Audiology , Hoensbroek , The Netherlands.|e Department of Rehabilitation Medicine, Research School CAPHRI , Maastricht University , Maastricht , The Netherlands.
authors.forename: S M C
authors.initials: SM
authors.lastname: Rasquin
authors.affiliation: f Department of Psychology , De Hoogstraat Rehabilitation , Utrecht , The Netherlands.
authors.forename: V A
authors.initials: VA
authors.lastname: Heijnen
authors.affiliation: a Brain Center Rudolf Magnus and Center of Excellence for Rehabilitation Medicine , University Medical Center Utrecht and De Hoogstraat Rehabilitation , Utrecht , The Netherlands.
authors.forename: J M A
authors.initials: JM
authors.lastname: Visser-Meily
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000175:diagnosis / Q000523:psychology* / Q000534:rehabilitation*; D003863:Depression; D056344:Executive Function; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D009483:Neuropsychological Tests; D010551:Personality; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D012047:Rehabilitation Centers; D012919:Social Behavior; D016896:Treatment Outcome; D055815:Young Adult
keywords: Adult; Neuropsychology; Prognosis; Stroke; Treatment outcome