title: Microfluidics Integrated Biosensors: A Leading Technology towards Lab-on-a-Chip and Sensing Applications.
abstract: A biosensor can be defined as a compact analytical device or unit incorporating a biological or biologically derived sensitive recognition element immobilized on a physicochemical transducer to measure one or more analytes. Microfluidic systems, on the other hand, provide throughput processing, enhance transport for controlling the flow conditions, increase the mixing rate of different reagents, reduce sample and reagents volume (down to nanoliter), increase sensitivity of detection, and utilize the same platform for both sample preparation and detection. In view of these advantages, the integration of microfluidic and biosensor technologies provides the ability to merge chemical and biological components into a single platform and offers new opportunities for future biosensing applications including portability, disposability, real-time detection, unprecedented accuracies, and simultaneous analysis of different analytes in a single device. This review aims at representing advances and achievements in the field of microfluidic-based biosensing. The review also presents examples extracted from the literature to demonstrate the advantages of merging microfluidic and biosensing technologies and illustrate the versatility that such integration promises in the future biosensing for emerging areas of biological engineering, biomedical studies, point-of-care diagnostics, environmental monitoring, and precision agriculture.
authors.affiliation: School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada. george.luka@ubc.ca.
authors.forename: George
authors.initials: G
authors.lastname: Luka
authors.affiliation: School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada. ali.ahmadi@ubc.ca.
authors.forename: Ali
authors.initials: A
authors.lastname: Ahmadi
authors.affiliation: School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada. homayoun.najjaran@ubc.ca.
authors.forename: Homayoun
authors.initials: H
authors.lastname: Najjaran
authors.affiliation: Nano-Biosensors Laboratory, Department of Biosystems and Agricultural Engineering, Michigan State University, 524 S. Shaw Lane, Room 115, East Lansing, MI 48224, USA. alocilja@msu.edu.
authors.forename: Evangelyn
authors.initials: E
authors.lastname: Alocilja
authors.affiliation: Carleton University, Department of Chemistry and Institute of Biochemistry, 225 Steacie Building 1125 Colonel By Drive Ottawa, ON K1S 5B6, Canada. maria_derosa@carleton.ca.
authors.forename: Maria
authors.initials: M
authors.lastname: DeRosa
authors.affiliation: School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada. kirsten.wolthers@ubc.ca.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Wolthers
authors.affiliation: Department of Health Sciences, College of Arts and Sciences, Qatar University, 2713 Doha, Qatar. ahmed.malki@qu.edu.qa.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Malki
authors.affiliation: Department of Health Sciences, College of Arts and Sciences, Qatar University, 2713 Doha, Qatar. hassan.aziz@qu.edu.qa.
authors.forename: Hassan
authors.initials: H
authors.lastname: Aziz
authors.affiliation: Department of Health Sciences, College of Arts and Sciences, Qatar University, 2713 Doha, Qatar. aaja@qu.edu.qa.|Biomedical Research Center, Qatar University, 2713 Doha, Qatar. aaja@qu.edu.qa.
authors.forename: Asmaa
authors.initials: A
authors.lastname: Althani
authors.affiliation: School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada. mina.hoorfar@ubc.ca.
authors.forename: Mina
authors.initials: M
authors.lastname: Hoorfar
mesh_terms: D015374:Biosensing Techniques; D056656:Lab-On-A-Chip Devices; D046210:Microfluidic Analytical Techniques
keywords: biosensor; lab-on-a-chip; micro total analysis systems (μTAS); microfluidic; microfluidic-based biosensor