title: Adenocarcinoma arising from heterotopic gastric mucosa in the cervical esophagus and upper thoracic esophagus: two case reports and literature review.
abstract: Primary adenocarcinoma arising from heterotopic gastric mucosa (HGM) is rare and the clinicopathological characteristics are not well known. We present two cases of esophageal adenocarcinoma arising from HGM with a review of a case series. Case 1 was a 78-year-old woman who underwent a periodic medical examination without complaining of any symptoms. Preoperative evaluation suggested esophageal adenocarcinoma arising from the HGM. The patient was treated with endoscopic submucosal dissection. Definitive pathological diagnosis confirmed adenocarcinoma arising from the HGM. Case 2 was a 70-year-old man who underwent a medical examination after complaining of dysphagia. Preoperative diagnosis suggested esophageal adenocarcinoma; however, its origin was unclear. The patient was treated with surgical resection. Definitive pathological diagnosis revealed adenocarcinoma arising from the HGM. In this article, the authors report the clinicopathological features of esophageal adenocarcinoma arising from HGM that were collected from a literature review and our cases.
authors.affiliation: a Department of Gastroenterology, Endoscopy Division , National Cancer Center Hospital East , Kashiwa , Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kadota
authors.affiliation: b Pathology Division, Research Center for Innovative Oncology , National Cancer Center Hospital East , Kashiwa , Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujii
authors.affiliation: a Department of Gastroenterology, Endoscopy Division , National Cancer Center Hospital East , Kashiwa , Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Oono
authors.affiliation: a Department of Gastroenterology, Endoscopy Division , National Cancer Center Hospital East , Kashiwa , Japan.
authors.forename: Maomi
authors.initials: M
authors.lastname: Imajoh
authors.affiliation: a Department of Gastroenterology, Endoscopy Division , National Cancer Center Hospital East , Kashiwa , Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Yano
authors.affiliation: a Department of Gastroenterology, Endoscopy Division , National Cancer Center Hospital East , Kashiwa , Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kaneko
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002828:Choristoma / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal; D004938:Esophageal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016629:Esophagectomy; D005260:Female; D005753:Gastric Mucosa; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009367:Neoplasm Staging; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: CK20; CK7; Esophageal adenocarcinoma; heterotopic gastric mucosa; inlet patch