title: Pleomorphic hyalinizing angiectatic tumor revisited: all tumors manifest typical morphologic features of myxoinflammatory fibroblastic sarcoma, further suggesting 2 morphologic variants of a single entity.
abstract: We describe 9 cases of pleomorphic hyalinizing angiectatic tumor (PHAT). Recently described TGFBR3 and MGEA5 gene rearrangements in these tumors have confirmed the long-hypothesized link between PHAT and another soft tissue entity, the myxoinflammatory fibroblastic sarcoma (MIFS). Myxoinflammatory fibroblastic sarcoma and PHAT share the same translocation and in addition have a very similar clinical presentation. However, to our best knowledge, no study has ever addressed the striking morphologic similarities between MIFS and PHAT. Our findings based on histological criteria suggest that most, if not all, tumors diagnosed as PHAT might, in fact, represent examples of MIFS that, in addition to a conventional MIFS morphology, manifest aberrant angiectatic hyalinized vessels.
authors.affiliation: Department of Pathology, Charles University, Biomedical Center, Faculty of Medicine in Plzen and Charles University Hospital Plzen, Czech Republic. Electronic address: michael.michal@medima.cz.
authors.forename: Michael
authors.initials: M
authors.lastname: Michal
authors.affiliation: Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Kazakov
authors.affiliation: Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
authors.forename: Ladislav
authors.initials: L
authors.lastname: Hadravský
authors.affiliation: Institute of Pathology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
authors.forename: Abbas
authors.initials: A
authors.lastname: Agaimy
authors.affiliation: Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic; Department of Pathology, Louis Pasteur University Hospital, Kosice, Slovakia.
authors.forename: Marián
authors.initials: M
authors.lastname: Švajdler
authors.affiliation: Red Cross Hospital Kochi, Kochi, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Kuroda
authors.affiliation: Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Michal
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Myxoinflammatory fibroblastic sarcoma; Pleomorphic hyalinizing angiectatic tumor; Soft tissues