title: Age-Related Sleep Disruption and Reduction in the Circadian Rhythm of Urine Output: Contribution to Nocturia?
abstract: Aging is associated with a marked increase in sleep complaints, and one factor causing sleep disruption is waking to void (nocturia). Urological surveys have found that few young adults report nocturia symptoms, but about half of those in their 60's and nearly 80% of older age groups are affected. Sleep surveys have found nocturia is a major cause of sleep disruption, with a majority of older adults with sleep disruption citing the need to void as the cause of their awakening. While much of the urological literature implies that nocturia causes sleep disruption, age-related changes in sleep depth and continuity may make it more likely that an older adult will wake in response to a filling bladder, or that an older adult will wake for another reason and then decide to void. There is also evidence that age-related changes in the amplitude of circadian rhythms contribute to nocturia. There is a well-described circadian rhythm in urine output, and evidence of circadian rhythmicity in some diuretic and anti-diuretic hormones. In this article, we describe how age-related changes in sleep depth and continuity and age-related changes in circadian rhythm amplitude may contribute to nocturia, and how nocturia in turn leads to sleep disruption. Better understanding of how changes in sleep and circadian rhythmicity impact nocturia may lead to improved treatments and better quality of life for older adults.
authors.affiliation: The Division of Sleep and Circadian Disorders, 221 Longwood Avenue BLI438, Boston, MA 02115 USA. jduffy@research.bwh.harvard.edu.
authors.forename: Jeanne F
authors.initials: JF
authors.lastname: Duffy
authors.forename: Karine
authors.initials: K
authors.lastname: Scheuermaier
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Loughlin
mesh_terms: D000375:Aging; D000818:Animals; D002940:Circadian Rhythm; D006801:Humans; D053158:Nocturia; D011788:Quality of Life; D012890:Sleep; D020181:Sleep Apnea, Obstructive