title: Histone deacetylase-mediated morphological transition in Candida albicans.
abstract: Candida albicans is the most common opportunistic fungal pathogen, which switches its morphology from single-cell yeast to filament through the various signaling pathways responding to diverse environmental cues. Various transcriptional factors such as Nrg1, Efg1, Brg1, Ssn6, and Tup1 are the key components of these signaling pathways. Since C. albicans can regulate its transcriptional gene expressions using common eukaryotic regulatory systems, its morphological transition by these signaling pathways could be linked to the epigenetic regulation by chromatin structure modifiers. Histone proteins, which are critical components of eukaryotic chromatin structure, can regulate the eukaryotic chromatin structure through their own modifications such as acetylation, methylation, phosphorylation and ubiquitylation. Recent studies revealed that various histone modifications, especially histone acetylation and deacetylation, participate in morphological transition of C. albicans collaborating with well-known transcription factors in the signaling pathways. Here, we review recent studies about chromatin-mediated morphological transition of C. albicans focusing on the interaction between transcription factors in the signaling pathways and histone deacetylases.
authors.affiliation: Department of Molecular Bioscience, College of Biomedical Science, Institute of Bioscience & Biotechnology, Kangwon National University, Chuncheon, 24341, Republic of Korea.
authors.forename: Jueun
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Molecular Bioscience, College of Biomedical Science, Institute of Bioscience & Biotechnology, Kangwon National University, Chuncheon, 24341, Republic of Korea.
authors.forename: Ji-Eun
authors.initials: JE
authors.lastname: Lee
authors.affiliation: Department of Molecular Bioscience, College of Biomedical Science, Institute of Bioscience & Biotechnology, Kangwon National University, Chuncheon, 24341, Republic of Korea. jungshinlee@kangwon.ac.kr.
authors.forename: Jung-Shin
authors.initials: JS
authors.lastname: Lee
mesh_terms: D002176:Candida albicans / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D044127:Epigenesis, Genetic; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D015966:Gene Expression Regulation, Fungal; D042421:Histone Code; D006655:Histone Deacetylases / Q000378:metabolism*; D025301:Hyphae / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D009024:Morphogenesis / Q000235:genetics*; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014774:Virulence / Q000235:genetics
chemical_list: D002843:Chromatin; D005656:Fungal Proteins; D014157:Transcription Factors; D006655:Histone Deacetylases
keywords: Candida albicans; chromatin structure; histone deacetylases (HDACs); morphological transition; transcription factor