title: Genetic polymorphisms of Trim5a are associated with disease progression in acutely and chronically HIV-infected patients.
abstract: BACKGROUND
  The tripartite interaction motif 5a (Trim5a) plays critical roles in restricting various kinds of retroviruses in different species. It has been shown that Trim5a could inhibit HIV-1 inhibition in vitro.
  
  
  METHODS
  In this study, 16 SNPs of Trim5a gene were screened in 236 acutely HIV-infected patients (169 common type (CT) patients and 67 patients with rapid disease progression). In addition, they were screened in 162 chronically HIV-infected patients (147 common type patients and 15 long-term non-progressors (LTNP)). The potential effects of polymorphisms at Trim5a genes on HIV-infection disease progression were analyzed.
  
  
  RESULTS
  Among all tested SNP sites, 3 SNPs (rs3824949, rs2291841 and rs11038628) were identified to be associated with rapid disease progression in acutely HIV-infected patients. Carriage of rs3824949 allele G, rs2291841 allele C or rs11038628 allele T associated with rapid disease progression. In chronically HIV-infected patients, Patients carrying rs3802981 allele C or rs3802980 allele A had increased opportunity to be LTNP. We also found that greater age was associated with disease deterioration.
  
  
  CONCLUSIONS
  Different genetic polymorphisms of Trim5a may have an impact on the clinical course of both acute and chronic stages of HIV-infection.
authors.affiliation: Minimally Invasive Therapy Center of Liver Cancer, Beijing You'an Hospital, Capital Medical University 8 Xitoutiao Youwai St, Fengtai District, Beijing 100069, P. R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Sun
authors.affiliation: Minimally Invasive Therapy Center of Liver Cancer, Beijing You'an Hospital, Capital Medical University 8 Xitoutiao Youwai St, Fengtai District, Beijing 100069, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Comprehensive Medicine, Baoding Hospital for Infectious Diseases Baoding, Hebei Province, China.
authors.forename: Wenzhen
authors.initials: W
authors.lastname: Liu
authors.affiliation: Minimally Invasive Therapy Center of Liver Cancer, Beijing You'an Hospital, Capital Medical University 8 Xitoutiao Youwai St, Fengtai District, Beijing 100069, P. R. China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: Minimally Invasive Therapy Center of Liver Cancer, Beijing You'an Hospital, Capital Medical University 8 Xitoutiao Youwai St, Fengtai District, Beijing 100069, P. R. China.
authors.forename: Qunhui
authors.initials: Q
authors.lastname: Li
authors.affiliation: Minimally Invasive Therapy Center of Liver Cancer, Beijing You'an Hospital, Capital Medical University 8 Xitoutiao Youwai St, Fengtai District, Beijing 100069, P. R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
keywords: HIV-1; Trim5a; disease progression; genetic polymorphisms