title: Reversible Fluoxetine-Induced Hyperthyroidism: A Case Report.
abstract: BACKGROUND
  Selective serotonin reuptake inhibitors (SSRIs) are typically used as antidepressants. Clinically significant SSRI-induced thyroid dysfunction is rare.
  
  
  METHODS
  We report a case of hyperthyroidism induced by fluoxetine in a female patient with major depressive disorder. Her thyroid profiles indicated hyperthyroidism after a 10-week treatment with fluoxetine and were restored after discontinuation of fluoxetine and administration with venlafaxine. In the first year of follow-up, her thyroid functions as well as her depressive symptoms remained perfectly normal.
  
  
  CONCLUSIONS
  This case highlights the necessity of monitoring thyroid profiles during SSRI treatment.
authors.affiliation: *Department of Mental Health, The First Affiliated Hospital, Zhejiang UniversitySchool of Medicine, Hangzhou, China; †MRI Unit, Epidemiology Division, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY; ‡Institute of the Developing Mind, Children's Hospital Los Angeles, Keck School of Medicine at the University of Southern California, Los Angeles, CA; §The Key Laboratory of Mental Disorder's Management in Zhejiang Province; and ∥Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Lai
authors.forename: Dongrong
authors.initials: D
authors.lastname: Xu
authors.forename: Bradley S
authors.initials: BS
authors.lastname: Peterson
authors.forename: Yi
authors.initials: Y
authors.lastname: Xu
authors.forename: Ning
authors.initials: N
authors.lastname: Wei
authors.forename: Minming
authors.initials: M
authors.lastname: Zhang
authors.forename: Shaohua
authors.initials: S
authors.lastname: Hu
mesh_terms: D000328:Adult; D055154:Dysphonia / Q000150:complications / Q000188:drug therapy; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects*; D006261:Headache / Q000150:complications / Q000188:drug therapy; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D007319:Sleep Initiation and Maintenance Disorders / Q000150:complications / Q000188:drug therapy
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors