title: A novel algorithm for analyzing drug-drug interactions from MEDLINE literature.
abstract: Drug-drug interaction (DDI) is becoming a serious clinical safety issue as the use of multiple medications becomes more common. Searching the MEDLINE database for journal articles related to DDI produces over 330,000 results. It is impossible to read and summarize these references manually. As the volume of biomedical reference in the MEDLINE database continues to expand at a rapid pace, automatic identification of DDIs from literature is becoming increasingly important. In this article, we present a random-sampling-based statistical algorithm to identify possible DDIs and the underlying mechanism from the substances field of MEDLINE records. The substances terms are essentially carriers of compound (including protein) information in a MEDLINE record. Four case studies on warfarin, ibuprofen, furosemide and sertraline implied that our method was able to rank possible DDIs with high accuracy (90.0% for warfarin, 83.3% for ibuprofen, 70.0% for furosemide and 100% for sertraline in the top 10% of a list of compounds ranked by p-value). A social network analysis of substance terms was also performed to construct networks between proteins and drug pairs to elucidate how the two drugs could interact.
authors.affiliation: Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA.
authors.forename: Yin
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Mathematics &Statistics, University of South Florida, Tampa, FL, 33612, USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Shen
authors.affiliation: Department of Computer Science and Engineering, University of South Florida, Tampa, FL, 33612, USA.
authors.forename: Maxwell
authors.initials: M
authors.lastname: Pietsch
authors.affiliation: Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA.
authors.forename: Chetan
authors.initials: C
authors.lastname: Nagar
authors.affiliation: College of Medicine, Syrian private university, Damascus, 0100, Syria.
authors.forename: Zayd
authors.initials: Z
authors.lastname: Fadli
authors.affiliation: School of Information, University of South Florida, Tampa, FL, 33612, USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Computer Science and Engineering, University of South Florida, Tampa, FL, 33612, USA.
authors.forename: Yi-Cheng
authors.initials: YC
authors.lastname: Tu
authors.affiliation: Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA.|Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa 33612, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Cheng
mesh_terms: D000465:Algorithms; D000075202:Contraindications; D004347:Drug Interactions; D004798:Enzymes / Q000378:metabolism; D005665:Furosemide / Q000627:therapeutic use*; D006801:Humans; D006868:Hydrolysis; D007052:Ibuprofen / Q000627:therapeutic use*; D016239:MEDLINE / Q000706:statistics & numerical data; D020280:Sertraline / Q000627:therapeutic use*; D014859:Warfarin / Q000627:therapeutic use*
chemical_list: D004798:Enzymes; D014859:Warfarin; D005665:Furosemide; D020280:Sertraline; D007052:Ibuprofen