title: SET8 expression is associated with overall survival in gastric cancer.
abstract: SET8, a member of the SET domain-containing methyl-transferase, has been implicated in various biological processes. In this study, SET8 was immunostained in 100 samples of gastric cancer tissues and semi-quantified using the HSCORE method to determine the predictive value of SET8 expression levels for gastric cancer outcome. The relationship between SET8 expression and the 5-year survival rate of gastric cancer patients was assessed. High expression of SET8 was associated with a shorter survival time in gastric cancer patients, and the level of SET8 expression was found to be an independent predictor of gastric cancer outcome (relative risk = 1.939; 95% confidence interval = 1.025-3.668; P = 0.042). Analysis of SET8 levels may help in the identification of patient subgroups that are at high risk for poor disease outcomes.
authors.affiliation: Department of Pain Medicine and Rehabilitation, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Shi
authors.affiliation: Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Guo
authors.affiliation: Department of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Wang
authors.affiliation: Department of Pain Medicine and Rehabilitation, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Liu
authors.affiliation: Department of Radiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: G F
authors.initials: GF
authors.lastname: Shi
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D015870:Gene Expression; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D047368:Tumor Burden
chemical_list: D011495:Histone-Lysine N-Methyltransferase; C470730:KMT5A protein, human