title: Bifunctional Furfuryl Cations Strategy: Three-Component Synthesis of Enamidyl Triazoles.
abstract: A new multicomponent synthesis of functionalized enamidyl triazoles starting from simple and readily available starting materials is described. A simple treatment of a dichloromethane solution of an azide, amine, and 5-bromo-2-furylcarbinol with a Lewis acid provides the enamidyl triazole in good to high yield. A triple domino sequence, formal [3+2] cycloaddition/ring-opening/amidation, is involved in this new skeleton-generating reaction.
authors.affiliation: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry, Chemical Engineering, Shaanxi Normal University, Xi'an 710062 (P.R. China).
authors.forename: Hengtuo
authors.initials: H
authors.lastname: Yang
authors.affiliation: School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062 (P.R. China).
authors.forename: Jing
authors.initials: J
authors.lastname: Gou
authors.affiliation: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry, Chemical Engineering, Shaanxi Normal University, Xi'an 710062 (P.R. China).
authors.forename: Jiawei
authors.initials: J
authors.lastname: Guo
authors.affiliation: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry, Chemical Engineering, Shaanxi Normal University, Xi'an 710062 (P.R. China).
authors.forename: Dongyu
authors.initials: D
authors.lastname: Duan
authors.affiliation: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry, Chemical Engineering, Shaanxi Normal University, Xi'an 710062 (P.R. China).
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry, Chemical Engineering, Shaanxi Normal University, Xi'an 710062 (P.R. China). yubx@snnu.edu.cn.
authors.forename: Binxun
authors.initials: B
authors.lastname: Yu
authors.affiliation: Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry, Chemical Engineering, Shaanxi Normal University, Xi'an 710062 (P.R. China).
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Gao
keywords: azides; cyclization; cycloaddition; heterocycles; ring opening; synthetic methods