title: Set-Shifting Ability Is Associated with Gray Matter Volume in Older People with Mild Cognitive Impairment.
abstract: OBJECTIVE
  An understanding of the association between gray matter volume and executive functioning could provide strategies to reduce dementia risk in older people with mild cognitive impairment (MCI).
  
  
  METHODS
  In a cross-sectional analysis, we assessed executive functioning in 83 older people with MCI using three standard neuropsychological tests: set shifting (difference between Trail Making Test Parts B and A), working memory (difference between Digit Span forward and backward from the Wechsler Adult Intelligence Scale-IV), and selective attention/response inhibition (difference between the second and third conditions of the color- and picture-word Stroop test). Gray matter volume was computed from brain MRIs and SIENAX from FSL software.
  
  
  RESULTS
  Gray matter volume was significantly associated with set-shifting performance after accounting for age, gender, body mass index, education, and global cognition (standardized β = -0.376, p = 0.001), but not with working memory or selective attention/response inhibition.
  
  
  CONCLUSIONS
  The executive function of set-shifting ability was correlated with gray matter volume in older people with MCI.
authors.affiliation: Department of Preventive Gerontology, Center for Gerontology and Social Science, Obu, Japan.
authors.forename: Kota
authors.initials: K
authors.lastname: Tsutsumimoto
authors.affiliation: Department of Preventive Gerontology, Center for Gerontology and Social Science, Obu, Japan.
authors.forename: Hyuma
authors.initials: H
authors.lastname: Makizako
authors.affiliation: Department of Preventive Gerontology, Center for Gerontology and Social Science, Obu, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimada
authors.affiliation: Department of Preventive Gerontology, Center for Gerontology and Social Science, Obu, Japan.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Doi
authors.affiliation: Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Suzuki
keywords: Executive functioning; Gray matter; Mild cognitive impairment