title: Poorly Differentiated Neuroendocrine Tumors.
abstract: Poorly differentiated neuroendocrine carcinomas of the gastrointestinal tract are rare and limited data are available to guide treatment. These tumors have been treated akin to small cell lung cancer given the histologic similarities. Their pathology is complex. Over the last decade, these tumors are shown as likely a distinct disease entity that is more heterogeneous than accounted for by the current classification system. This article discusses the epidemiology, prognosis, clinical presentation and pathologic nuances and provides a review of the existing clinical data in poorly differentiated neuroendocrine carcinomas and small cell lung cancers.
authors.affiliation: Division of Hematology and Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Case Comprehensive Cancer, 11100 Euclid Avenue, Lakeside 1200, Cleveland, OH 44106, USA. Electronic address: jennifer.eads@uhhospitals.org.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Eads
mesh_terms: D004358:Drug Therapy / Q000379:methods; D005770:Gastrointestinal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D011379:Prognosis; D011878:Radiotherapy / Q000379:methods; D013514:Surgical Procedures, Operative / Q000379:methods; D016019:Survival Analysis
chemical_list: D019394:Ki-67 Antigen
keywords: G3; High-grade; Neuroendocrine carcinoma; Neuroendocrine tumor; Poorly differentiated