title: Chemotherapy in Children with Head and Neck Cancers: Perspectives and Review of Current Therapies.
abstract: Cancers of the head and neck in children represent a heterogeneous group of malignancies requiring a variety of treatment modalities. In many instances of childhood head and neck cancers, chemotherapy will be required for treatment, often in conjunction with surgery and/or radiation therapy. Chemotherapy in children with head and neck cancers poses unique challenges in terms of immediate as well as long-term toxicities. This article focuses on the common chemotherapeutic agents, with a particular focus on early and late effects, used in the treatment of children with head and neck cancers.
authors.affiliation: Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Illinois at Chicago College of Medicine, 840 South Wood Street, MC 856, Chicago, IL 60612, USA. Electronic address: dkchoi@uic.edu.
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Choi
authors.affiliation: Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Illinois at Chicago College of Medicine, 840 South Wood Street, MC 856, Chicago, IL 60612, USA.
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Schmidt
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000628:therapy; D006801:Humans
chemical_list: D000970:Antineoplastic Agents
keywords: Chemotherapy; Lymphoma; Neuroblastoma; Pediatric cancer; Retinoblastoma; Rhabdomyosarcoma