title: Cancer Incidence in Heart Transplant Recipients With Previous Neoplasia History.
abstract: Neoplasm history increases morbidity and mortality after solid organ transplantation and has disqualified patients from transplantation. Studies are needed to identify factors to be considered when deciding on the suitability of a patient with previous tumor for heart transplantation. A retrospective epidemiological study was conducted in heart transplant (HT) recipients (Spanish Post-Heart Transplant Tumor Registry) comparing the epidemiological data, immu-nosuppressive treatments and incidence of post-HT tumors between patients with previous malignant noncardiac tumor and with no previous tumor (NPT). The impact of previous tumor (PT) on overall survival (OS) was also assessed. A total of 4561 patients, 77 PT and 4484 NPT, were evaluated. The NPT group had a higher proportion of men than the PT group (p < 0.001). The incidence of post-HT tumors was 1.8 times greater in the PT group (95% confidence interval [CI] 1.2-2.6; p < 0.001), mainly due to the increased risk in patients with a previous hematologic tumor (rate ratio 2.3, 95% CI 1.3-4.0, p < 0.004). OS during the 10-year posttransplant period was significantly lower in the PT than the NPT group (p = 0.048) but similar when the analysis was conducted after a first post-HT tumor was diagnosed. In conclusion, a history of PT increases the incidence of post-HT tumors and should be taken into account when considering a patient for HT.
authors.affiliation: Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: J F
authors.initials: JF
authors.lastname: Delgado
authors.affiliation: Hospital Universitario Puerta de Hierro, Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Alonso-Pulpón
authors.affiliation: Hospital Santa Creu i Sant Pau, Barcelona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Mirabet
authors.affiliation: Hospital Universitari i Politècnic La Fe, Valencia, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Almenar
authors.affiliation: Hospital Clínic i Provincial, Barcelona, Spain.
authors.forename: F P
authors.initials: FP
authors.lastname: Villa
authors.affiliation: Hospital Universitario Marqués de Valdecilla, Santander, Spain.
authors.forename: F
authors.initials: F
authors.lastname: González-Vílchez
authors.affiliation: Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Palomo
authors.affiliation: Hospital Universitario Miguel Servet, Zaragoza, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Blasco
authors.affiliation: Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Dolores García-Cosio
authors.affiliation: Hospital Universitari de Bellvitge, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: González-Costello
authors.affiliation: Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: de la Fuente
authors.affiliation: Clínica Universidad de Navarra, Pamplona, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Rábago
authors.affiliation: Hospital Universitario Virgen del Rocío, Sevilla, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Lage
authors.affiliation: Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Pascual
authors.affiliation: Hospital Universitario Central de Asturias, Oviedo, Spain.
authors.forename: B D
authors.initials: BD
authors.lastname: Molina
authors.affiliation: Hospital Universitario Reina Sofía, Córdoba, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Arizón
authors.affiliation: Instituto Universitario de Ciencias de la Salud, Instituto de Investigación Biomédica de A Coruña (INIBIC), Universidade da Coruña, La Coruña, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Muñiz
authors.affiliation: Hospital Universitario A Coruña, La Coruña, Spain.
authors.forename: M G
authors.initials: MG
authors.lastname: Crespo-Leiro
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000150:complications* / Q000601:surgery; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000503:physiopathology*; D011183:Postoperative Complications / Q000453:epidemiology*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D013997:Time Factors