title: A Randomized, Controlled Trial of Catheter-Related Infectious Event Rates Using Antibiotic-Impregnated Catheters Versus Conventional Catheters in Pediatric Cardiovascular Surgery Patients.
abstract: : We conducted a randomized, controlled clinical trial to determine whether a difference in catheter-associated blood stream infection (CABSI) incidence existed between children who underwent cardiac surgery and had a central venous catheter impregnated with minocycline and rifampin versus those who had a conventional, nonimpregnated catheter after cardiac surgery. Due to a lower number of infections than expected, the study was terminated early. Among 288 evaluable patients, the rates of CABSI and line-related complications were similar between the 2 groups.
authors.affiliation: Section of Pediatric Infectious Disease, Indiana University School of Medicine.
authors.forename: Elaine G
authors.initials: EG
authors.lastname: Cox
authors.affiliation: Section of Pediatric Infectious Disease, Indiana University School of Medicine Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Butler University.
authors.forename: Chad A
authors.initials: CA
authors.lastname: Knoderer
authors.affiliation: Department of Nursing.
authors.forename: Aimee
authors.initials: A
authors.lastname: Jennings
authors.affiliation: Division of Cardiothoracic Surgery.
authors.forename: John W
authors.initials: JW
authors.lastname: Brown
authors.affiliation: Division of Cardiothoracic Surgery.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Rodefeld
authors.affiliation: Department of Anesthesia, Indiana University School of Medicine, Indianapolis, Indiana.
authors.forename: Scott G
authors.initials: SG
authors.lastname: Walker
authors.affiliation: Division of Cardiothoracic Surgery.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Turrentine