title: [Relationship between primary lung cancer and tobacco consumption. Results of the KBP-2010-CPHG study by the French College of General Hospital Respiratory Physicians].
abstract: BACKGROUND
  The Collège des Pneumologues des Hôpitaux Généraux has performed a prospective multicentre epidemiological study which aims to describe the baseline characteristics of all new cases of primary lung cancer histologically or cytologically diagnosed in 2010 and followed-up in the respiratory department of general hospitals. The present publication compares the characteristics of these presentations according to their smoking history.
  
  
  METHODS
  Seven thousand and fifty-one adult patients were included from 104 respiratory departments. A standardized form was completed at diagnosis and a steering committee checked the completeness of inclusion.
  
  
  RESULTS
  Only 10.9% of patients were never-smokers and 89.1% ever-smokers (i.e., current or former smokers). Respectively, 3.7%, 10.7% and 85.6% of ever-smokers consumed/had consumed 1-10, 11-20, and >20 pack-years. Mean smoking duration was 37.5 years. Former smokers had stopped smoking on average 14.8 years previously. Only 20.7% of never-smokers reported that they had been exposed to tobacco smoke passively. At diagnosis, statistically significant differences were found between never- and ever-smokers (P<0.0001) for sex (women: 60.8% vs 18.8%), age (mean: 70.7 years vs 64.9 years), stage (IV: 70.8% vs 58.7%), histology (adenocarcinoma: 68.5% vs 42.6%), EGFR mutation exploration (51.4% vs 28.0%) and positivity (37.0% vs 4.6%). Differences between never- and ever-smokers rose with increasing tobacco consumption.
  
  
  CONCLUSIONS
  This study confirms that differences exist between never- and ever-smoker patients presenting with primary lung cancer and shows the impact of the level of tobacco consumption, in particular on histology.
authors.affiliation: Service de pneumologie et d'oncologie thoracique, hôpital Yves-Le-Foll, 10, rue Marcel-Proust, 22027 Saint-Brieuc cedex 1, France. Electronic address: daniel.coetmeur@ch-stbrieuc.fr.
authors.forename: D
authors.initials: D
authors.lastname: Coëtmeur
authors.affiliation: Service de pneumologie et d'oncologie thoracique, hôpital Yves-Le-Foll, 10, rue Marcel-Proust, 22027 Saint-Brieuc cedex 1, France.
authors.forename: G
authors.initials: G
authors.lastname: Leveiller
authors.affiliation: Service de pneumologie, centre hospitalier Métropole Savoie, 73000 Chambéry, France.
authors.forename: V
authors.initials: V
authors.lastname: Frappat
authors.affiliation: Service de pneumologie, centre hospitalier d'Angoulême, 16959 Angoulême, France.
authors.forename: M
authors.initials: M
authors.lastname: Martin
authors.affiliation: Service de pneumologie, hôpital Jacques-Monod, centre hospitalier Le Havre, 76290 Montivilliers, France.
authors.forename: M
authors.initials: M
authors.lastname: Peureux
authors.affiliation: Service de pneumologie, centre hospitalier Compiègne-Noyon, 60200 Compiègne, France.
authors.forename: S
authors.initials: S
authors.lastname: Dehette
authors.affiliation: Service de pneumologie, centre hospitalier Auban-Moët, 51205 Epernay, France.
authors.forename: M
authors.initials: M
authors.lastname: Carbonnelle
authors.affiliation: Service de pneumologie, centre hospitalier de Saint-Quentin, 02321 Saint-Quentin cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Dayen
authors.affiliation: Service de pneumologie, hôpital Émile-Muller, 68070 Mulhouse, France.
authors.forename: D
authors.initials: D
authors.lastname: Debieuvre
authors.affiliation: Service de pneumologie, centre hospitalier de Meaux, 77104 Meaux cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Grivaux
mesh_terms: D000328:Adult; D005260:Female; D005602:France / Q000453:epidemiology; D006769:Hospitals, General; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D015272:Pulmonary Medicine; D012907:Smoking / Q000453:epidemiology*; D014028:Tobacco Smoke Pollution / Q000706:statistics & numerical data; D064424:Tobacco Use / Q000453:epidemiology*
chemical_list: D014028:Tobacco Smoke Pollution
keywords: Cancer bronchique primitif; Consommation de tabac; Epidemiologic study; France; Primary lung cancer; Smoking; Tabagisme; Tobacco consumption; Étude épidémiologique