title: Response to pomalidomide plus fixed low-dose dexamethasone in a case of secondary plasma cell leukaemia.
abstract: This is, to our knowledge, the first reported case of secondary Plasma Cell Leukemia that was successfully by pomalidomide plus fixed low-dose dexamethasone. Pomalidomide at a dosage of 4 mg orally on days 1-21 of repeated 28-day cycles associated with fixed low-dose dexamethasone (40 mg on days 1, 8, 15 and 22 of each 28-day cycle), outside of the clinical trials, was started as a final attempt. After the fourth course, the patient achieved an interesting response that included a significant reduction of circulating plasma cells from the peripheral blood, a very important decrease of the M-component, and normalization of haematological value. The toxicities were acceptable. The time to best response was 4 months.
authors.affiliation: Haematology and BMT Unit-"Antonio Perrino" Hospital, 72100 Brindisi, Italy. Electronic address: giuseppemele2007@gmail.com.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mele
authors.affiliation: Haematology and BMT Unit-"Antonio Perrino" Hospital, 72100 Brindisi, Italy.
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Coppi
authors.affiliation: Haematology and BMT Unit-"Antonio Perrino" Hospital, 72100 Brindisi, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Guaragna
authors.affiliation: Haematology and BMT Unit-"Antonio Perrino" Hospital, 72100 Brindisi, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Spina
authors.affiliation: Haematology and BMT Unit-"Antonio Perrino" Hospital, 72100 Brindisi, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Melpignano
mesh_terms: D000368:Aged; D003907:Dexamethasone / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007952:Leukemia, Plasma Cell / Q000188:drug therapy*; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D013792:Thalidomide; D003907:Dexamethasone; C467566:pomalidomide
keywords: Dexamethasone; Pomalidomide; Secondary plasma cell leukemia