title: Protective Effect of Ocimum basilicum Essential Oil Against Acetic Acid-Induced Colitis in Rats.
abstract: Ocimum basilicum L has been traditionally used for the treatment of inflammatory bowel disease in Iran. This study investigates the ameliorative effect of Ocimum basilicum essential oil on an acetic acid-induced colitis model in rats. Ocimum basilicum essential oil with 2 doses (200 and 400 μL/kg) significantly ameliorated wet weight/length ratio of colonic tissue compared to the control group. Higher doses of essential oil (200 and 400 μL/kg) significantly reduced ulcer severity, ulcer area, and ulcer index. On the other hand, histological examination revealed the diminution of total colitis index as a marker for inflammatory cell infiltration in the colonic segments of rats treated with Ocimum basilicum essential oil (200 and 400 μL/kg). The increased level of myeloperoxidase was significantly decreased after the treatment with the essential oil (200 and 400 μL/kg). These results suggest that Ocimum basilicum exhibits protective effect against acetic acid-induced colitis.
authors.affiliation: Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Rashidian
authors.affiliation: Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Parnia
authors.initials: P
authors.lastname: Roohi
authors.affiliation: Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Mehrzadi
authors.affiliation: Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Ghannadi
authors.affiliation: Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran minaiyan@pharm.mui.ac.ir.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Minaiyan
mesh_terms: D019342:Acetic Acid / Q000009:adverse effects; D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D003106:Colon / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D004195:Disease Models, Animal; D007492:Iran; D008297:Male; D018649:Ocimum basilicum / Q000737:chemistry*; D009822:Oils, Volatile / Q000494:pharmacology* / Q000627:therapeutic use; D009195:Peroxidase; D020011:Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009822:Oils, Volatile; D020011:Protective Agents; D009195:Peroxidase; D019342:Acetic Acid
keywords: Ocimum basilicum; acetic acid; colitis; myeloperoxidase; traditional medicine; volatile constituents