title: CCR 20th Anniversary Commentary: Molecular Pathology of ALK-Rearranged Lung Tumors.
abstract: The article by Rodig and colleagues, which was published in the August 15, 2009, issue of Clinical Cancer Research, helped detail the clinicopathologic profile of ALK-positive tumors and initiated the development of ALK diagnostics. Subsequent clinical trials utilized these findings, resulting in the approval of effective targeted therapies. The ALK story is a model for the development of therapies in the genomic era.
authors.affiliation: Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts. aiafrate@partners.org.
authors.forename: A John
authors.initials: AJ
authors.lastname: Iafrate
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology*; D008297:Male; D011505:Protein-Tyrosine Kinases / Q000235:genetics*
chemical_list: D011505:Protein-Tyrosine Kinases