title: Chemical and Radiation-Associated Jaw Lesions.
abstract: Osteonecrosis of the jaw is a major public health concern throughout the world. Use of radiotherapy for head and neck cancer and bone antiresorptives and antiangiogenic agents have increased its incidence. Medication-related osteonecrosis of the jaw is more common relative to other types of osteonecrosis. Osteoradionecrosis occurs despite better treatment planning and shielding to minimize collateral damage to bone. Other related necrotic lesions are secondary to usage of recreational drugs and steroids. This article provides comprehensive information about these different types of bone necrosis; provides the readers with radiographic diagnostic criteria and updates on current theories on pathophysiology of osteonecrosis.
authors.affiliation: Department of Oral Medicine, University of Pennsylvania School of Dental Medicine, Robert Schattner Center Room 211, 240 South 40th Street, Philadelphia, PA 19104, USA.
authors.forename: Temitope T
authors.initials: TT
authors.lastname: Omolehinwa
authors.affiliation: Department of Oral Medicine, University of Pennsylvania School of Dental Medicine, Robert Schattner Center Room 211, 240 South 40th Street, Philadelphia, PA 19104, USA. Electronic address: akintoye@dental.upenn.edu.
authors.forename: Sunday O
authors.initials: SO
authors.lastname: Akintoye
mesh_terms: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D006801:Humans; D007568:Jaw; D007571:Jaw Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000628:therapy; D010020:Osteonecrosis / Q000175:diagnosis; D010025:Osteoradionecrosis / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000628:therapy
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates
keywords: Chemical; Damage; Diseases; Medication-related osteonecrosis; Necrosis; Osteoradionecrosis; Radiation; Recreational drug