title: Multivariate optimization of photochemical vapor generation for direct determination of arsenic in seawater by inductively coupled plasma mass spectrometry.
abstract: Photochemical vapor generation (PVG) sample introduction coupled to inductively coupled plasma mass spectrometry (ICPMS) is described for the determination of As in seawater. A Plackett-Burman design (PBD) and central composite design (CCD) were employed to evaluate the significance of experimental variables relevant to the optimization of PVG-ICPMS detection. The impact of the saline matrix on the suppression of analyte signal was eliminated by use of a mixture of 20% (v/v) formic and 20% acetic acid (v/v) as the photochemical reductants. Optimized conditions yielded equivalent PVG generation efficiencies for As(III), As(V), monomethylarsonic acids (MMAs) and dimethylarsinic acids (DMAs), permitting direct and rapid determination of total arsenic in seawater without any other sample pre-treatment. Quantitation was accomplished using one point gravimetric standard addition along with a spike of (82)Se internal standard to compensate for signal drift and fluctuation during analysis. The resulting method detection limit of 3 pg g(-1) (3σ) provided a 15-fold improvement over that obtained using direct solution nebulization, and is comparable to that for conventional chemical hydride generation (HG)-ICPMS. Accuracy was demonstrated by analysis of two Certified Reference Materials (NASS-6 and CASS-5 seawater) with satisfying results characterized by precisions of 3.5% and 3.2% RSD for CASS-5 and NASS-6, respectively.
authors.affiliation: National Research Council Canada, Ottawa, Ontario K1A 0R6, Canada; College of Earth Sciences, Chengdu University of Technology Chengdu, Sichuan 610059, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.affiliation: National Research Council Canada, Ottawa, Ontario K1A 0R6, Canada.
authors.forename: Ralph E
authors.initials: RE
authors.lastname: Sturgeon
authors.affiliation: National Research Council Canada, Ottawa, Ontario K1A 0R6, Canada.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Mester
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China.
authors.forename: Xiandeng
authors.initials: X
authors.lastname: Hou
authors.affiliation: National Research Council Canada, Ottawa, Ontario K1A 0R6, Canada. Electronic address: lu.yang@nrc-cnrc.gc.ca.
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
keywords: As; Inductively coupled plasma mass spectrometry; One point gravimetric standard addition and internal standardization; UV photochemical vapor generation