title: Risk factors for carbapenemase-producing Enterobacteriaceae colonization of asymptomatic carriers on admission to an Italian rehabilitation hospital.
abstract: The spread of carbapenemase-producing Enterobacteriaceae (CPE) has become a worldwide problem. Early identification and isolation of asymptomatic carriers are important for infection prevention and control measures. All inpatients (N=1427) admitted to 'Fondazione Santa Lucia' Rehabilitation Hospital in 2014 were screened by rectal swab; 10.2% of them were CPE-colonized. The multivariate analysis on anamnestic data showed that both previous admission to an intensive care unit (odds ratio: 4.04; 95% confidence interval: 2.20-7.44; P<0.001) or post-acute care hospitals (2.88; 1.74-4.77; P<0.001) and presence of a central venous catheter (2.19; 1.34-3.59; P<0.001) were significant risk factors.
authors.affiliation: Fondazione Santa Lucia I.R.C.C.S, Rome, Italy. Electronic address: a.rossini@hsantalucia.it.
authors.forename: A
authors.initials: A
authors.lastname: Rossini
authors.affiliation: Fondazione Santa Lucia I.R.C.C.S, Rome, Italy.
authors.forename: S G
authors.initials: SG
authors.lastname: Di Santo
authors.affiliation: Fondazione Santa Lucia I.R.C.C.S, Rome, Italy.
authors.forename: M F
authors.initials: MF
authors.lastname: Libori
authors.affiliation: Fondazione Santa Lucia I.R.C.C.S, Rome, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Tiracchia
authors.affiliation: Fondazione Santa Lucia I.R.C.C.S, Rome, Italy.
authors.forename: M P
authors.initials: MP
authors.lastname: Balice
authors.affiliation: Fondazione Santa Lucia I.R.C.C.S, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Salvia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006761:Hospitals; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D012007:Rectum / Q000382:microbiology; D012047:Rehabilitation Centers; D012307:Risk Factors; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase
keywords: Carbapenemase; Carriage; Rehabilitation; Resistance epidemiology; Surveillance