title: Response to low dose indomethacin in two children with nephrogenic diabetes insipidus.
abstract: Two children with nephrogenic diabetes insipidus (NDI) were treated with oral indomethacin (0.75-1.2 mg/kg/day) three times a day for a mean duration of 3 yrs. Remission occurred in both patients in terms of achieving a normal fluid balance and body growth and the drug was withdrawn in one patient after 2 yrs. The treatment was well tolerated and no side effects were noted. The mean duration of follow-up was 6.5 yrs. These long-term observations of a favourable response to low dose indomethacin in 2 children with NDI need to be tested on larger number of patients.
authors.affiliation: Additional Professor, Pediatric Endocrinology & Diabetes Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh.
authors.forename: Devi
authors.initials: D
authors.lastname: Dayal
authors.affiliation: Additional Professor, Pediatric Biochemistry, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh.
authors.forename: Savita
authors.initials: S
authors.lastname: Verma Attri
authors.affiliation: Additional Professor, Child Growth and Anthropology Unit, Department of Pediatrics, Postgraduate Insti- tute of Medical Education and Research, Chandigarh.
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar Bhalla
authors.affiliation: Associate Professor, Pediatric Endocrinology & Diabetes Unit, Department of Pediatrics, Postgraduate Insti- tute of Medical Education and Research, Chandigarh.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Kumar
mesh_terms: D002648:Child; D002675:Child, Preschool; D018500:Diabetes Insipidus, Nephrogenic / Q000175:diagnosis* / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D011044:Poland; D016896:Treatment Outcome
chemical_list: D007213:Indomethacin
keywords: children; cyclooxygenase inhibitors; indomethacin; nephrogenic diabetes insipidus