title: Determination of Solubility Parameters of Ibuprofen and Ibuprofen Lysinate.
abstract: In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable problem by these dispersions is drug-carrier (in)solubility. Here we focus on solubility parameters as a tool for predicting the solubility of a drug in certain carriers. Solubility parameters were determined in two different ways: solely by using calculation methods, and by experimental approaches. Six different calculation methods were applied in order to calculate the solubility parameters of the drug ibuprofen and several excipients. However, we were not able to do so in the case of ibuprofen lysinate, as calculation models for salts are still not defined. Therefore, the extended Hansen's approach and inverse gas chromatography (IGC) were used for evaluating of solubility parameters for ibuprofen lysinate. The obtained values of the total solubility parameter did not differ much between the two methods: by the extended Hansen's approach it was δt = 31.15 MPa(0.5) and with IGC it was δt = 35.17 MPa(0.5). However, the values of partial solubility parameters, i.e., δd, δp and δh, did differ from each other, what might be due to the complex behaviour of a salt in the presence of various solvents.
authors.affiliation: Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia. teja.kitak@gmail.com.
authors.forename: Teja
authors.initials: T
authors.lastname: Kitak
authors.affiliation: Zenitva k.s., U Kabelovny 130, 102 37 Prague 10, Czech Republic. aleksandra.dumicic@zentiva.cz.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Dumičić
authors.affiliation: Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia. odon.planinsek@ffa.uni-lj.si.
authors.forename: Odon
authors.initials: O
authors.lastname: Planinšek
authors.affiliation: Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia. rok.sibanc@ffa.uni-lj.si.
authors.forename: Rok
authors.initials: R
authors.lastname: Šibanc
authors.affiliation: Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia. srcics@ffa.uni-lj.si.
authors.forename: Stanko
authors.initials: S
authors.lastname: Srčič
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002849:Chromatography, Gas; D004337:Drug Carriers; D005079:Excipients / Q000737:chemistry*; D007052:Ibuprofen / Q000031:analogs & derivatives* / Q000737:chemistry*; D008239:Lysine / Q000031:analogs & derivatives* / Q000737:chemistry; D012997:Solvents / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D005079:Excipients; D012997:Solvents; D008239:Lysine; C016106:solufenum; D007052:Ibuprofen
keywords: Hansen’s solubility parameters; extended Hansen’s approach; ibuprofen; ibuprofen lysinate; inverse gas chromatography