title: Subjective Memory Complaints in APOEɛ4 Carriers are Associated with High Amyloid-β Burden.
abstract: BACKGROUND
  APOEɛ4 genotype and aging have been identified as risk factors for Alzheimer's disease (AD). In addition, subjective memory complaints (SMC) might be a first clinical expression of the effect of AD pathology on cognitive functioning.
  
  
  OBJECTIVE
  To assess whether APOEɛ4 genotype, age, SMC, and episodic memory are risk factors for high amyloid-β (Aβ) burden in cognitively normal elderly.
  
  
  METHODS
  307 cognitively normal participants (72.7 ± 6.8 years, 53% female, 55% SMC) from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study underwent amyloid PET and APOE genotyping. Logistic regression analyses were performed to determine the association of APOEɛ4 genotype, age, SMC, and episodic memory with Aβ pathology.
  
  
  RESULTS
  Odds of high Aβ burden were greater at an older age (OR = 3.21; 95% CI = 1.68-6.14), when SMC were present (OR = 1.90; 95% CI = 1.03-3.48), and for APOEɛ4 carriers (OR = 7.49; 95% CI = 3.96-14.15), while episodic memory was not associated with odds of high Aβ burden. Stratified analyses showed that odds of SMC for high Aβ burden were increased in specifically APOEɛ4 carriers (OR = 4.58, 95% CI = 1.83-11.49) and younger participants (OR = 3.73, 95% CI = 1.39-10.01).
  
  
  CONCLUSIONS
  Aging, APOEɛ4 genotype, and SMC were associated with high Aβ burden. SMC were especially indicative of high Aβ burden in younger participants and in APOEɛ4 carriers. These findings suggest that selection based on the presence of SMC, APOEɛ4 genotype and age may help identify healthy elderly participants with high Aβ burden eligible for secondary prevention trials.
authors.affiliation: Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.|Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia.
authors.forename: Marissa D
authors.initials: MD
authors.lastname: Zwan
authors.affiliation: Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia.|The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.
authors.forename: Victor L
authors.initials: VL
authors.lastname: Villemagne
authors.affiliation: CSIRO Digital Productivity Flagship, The Australian e-Health Research Centre - BioMedIA, Herston, Queensland, Australia.
authors.forename: Vincent
authors.initials: V
authors.lastname: Doré
authors.affiliation: The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.|Melbourne School of Psychological Sciences, The University of Melbourne, Victoria, Australia.
authors.forename: Rachel
authors.initials: R
authors.lastname: Buckley
authors.affiliation: CSIRO Digital Productivity Flagship, The Australian e-Health Research Centre - BioMedIA, Herston, Queensland, Australia.
authors.forename: Pierrick
authors.initials: P
authors.lastname: Bourgeat
authors.affiliation: Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia.
authors.forename: Robyn
authors.initials: R
authors.lastname: Veljanoski
authors.affiliation: CSIRO Digital Productivity Flagship, The Australian e-Health Research Centre - BioMedIA, Herston, Queensland, Australia.
authors.forename: Olivier
authors.initials: O
authors.lastname: Salvado
authors.affiliation: The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.
authors.forename: Rob
authors.initials: R
authors.lastname: Williams
authors.affiliation: Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia.
authors.forename: Laura
authors.initials: L
authors.lastname: Margison
authors.affiliation: The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.
authors.forename: Alan
authors.initials: A
authors.lastname: Rembach
authors.affiliation: CSIRO Food and Nutrion Flagship, Parkville, Victoria, Australia.
authors.forename: S Lance
authors.initials: SL
authors.lastname: Macaulay
authors.affiliation: Centre of Excellence for Alzheimer's Disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
authors.forename: Ralph
authors.initials: R
authors.lastname: Martins
authors.affiliation: National Ageing Research Institute, Parkville, Victoria, Australia.|Department of Psychiatry, The University of Melbourne, Victoria, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Ames
authors.affiliation: Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.|Department of Epidemiology and Biostatistics, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Wiesje M
authors.initials: WM
authors.lastname: van der Flier
authors.affiliation: The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.|Department of Psychiatry, The University of Melbourne, Victoria, Australia.
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Ellis
authors.affiliation: Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.affiliation: The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.
authors.forename: Colin L
authors.initials: CL
authors.lastname: Masters
authors.affiliation: Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Rowe
mesh_terms: D000368:Aged; D000375:Aging / Q000235:genetics / Q000378:metabolism / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds; D053327:Apolipoprotein E4 / Q000235:genetics*; D052160:Benzothiazoles; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000235:genetics* / Q000378:metabolism* / Q000523:psychology; D005260:Female; D060005:Genotyping Techniques; D006579:Heterozygote; D006801:Humans; D016015:Logistic Models; D008297:Male; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D053327:Apolipoprotein E4; D052160:Benzothiazoles; D019275:Radiopharmaceuticals; D013844:Thiazoles; C581552:flutemetamol
keywords: Aging; [11C]-PiB; [18F]flutemetamol; amyloid-β; apolipoprotein E; episodic memory; positron emission tomography