title: Prognostic value of total bilirubin in patients with angina pectoris undergoing percutaneous coronary intervention.
abstract: BACKGROUND
  Bilirubin is a potent antioxidant and previous studies have reported the relationship between low serum bilirubin concentration and atherosclerosis.
  
  
  OBJECTIVE
  To evaluate the prognostic value of serum total bilirubin (STB) in patients with angina pectoris undergoing percutaneous coronary intervention (PCI).
  
  
  METHODS
  In total of 1419 patients (931 men, mean age 60.9±10.5 years) with angina pectoris who had undergone successfully percutaneous coronary intervention (PCI) were included in this study. Patients were divided into 2 groups according to the median baseline STB (0.49 mg/dL in this cohort), which was measured before the PCI. Patients with a STB ≥0.49 mg/dL were classified into the high STB group and those with a STB <0.49 mg/dL were classified into the low STB group.
  
  
  RESULTS
  The incidence of in-hospital mortality and myocardial infraction was similar in the two groups. After a mean follow-up of 29.0±7.6 months, the incidence of death/myocardial infarction/stroke was significantly higher in low STB group compared with high STB group. Multivariate Cox regression analysis showed that low STB was an independent predictor of death/myocardial infarction/stroke (hazard ratio (HR) = 1.59, 95% confidence interval (CI) = 1.04-2.41, P = 0.031). The cumulative survival rate free from death/myocardial infarction/stroke was lower in low STB group than in high STB group (P = 0.002).
  
  
  CONCLUSIONS
  Low STB levels before PCI is an independent predictor of long-term adverse clinical outcomes in patients with angina pectoris.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.
authors.forename: Hai-Mu
authors.initials: HM
authors.lastname: Yao
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.
authors.forename: De-Liang
authors.initials: DL
authors.lastname: Shen
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Wang
authors.affiliation: Department of Integrated ICU, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.
authors.forename: Tong-Wen
authors.initials: TW
authors.lastname: Sun
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.
authors.forename: Jin-Ying
authors.initials: JY
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.
authors.forename: Luo-Sha
authors.initials: LS
authors.lastname: Zhao
keywords: Bilirubin; angina pectoris; percutaneous coronary intervention