title: Cancer immunosurveillance: role of patrolling monocytes.
abstract: Classical inflammatory monocytes and their derivative macrophages promote tumor metastasis whereas CD8(+) T and NK cells restrict tumor growth. In a recent paper published in Science, Hanna and colleagues demonstrate that another monocyte population, nonclassical patrolling monocytes, is enriched in the microvasculature of tumor-challenged lung and reduces tumor metastasis by recruiting NK cells.
authors.affiliation: MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
authors.forename: Luca
authors.initials: L
authors.lastname: Cassetta
authors.affiliation: MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.|Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA.
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Pollard
mesh_terms: D000818:Animals; D016827:CD8 Antigens / Q000276:immunology; D018925:Chemokines / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology*; D008168:Lung / Q000098:blood supply / Q000276:immunology*; D008175:Lung Neoplasms / Q000098:blood supply / Q000276:immunology* / Q000556:secondary*; D009000:Monocytes / Q000276:immunology*; D009362:Neoplasm Metastasis / Q000276:immunology
chemical_list: D016827:CD8 Antigens; D018925:Chemokines