title: The impact of Anastrazole and Letrozole on the metabolic profile in an experimental animal model.
abstract: Anastrazole and Letrozole are used as endocrine therapy for breast cancer patients. Previous studies suggested a possible association with metabolic and liver adverse effects. Their results are conflicting. Fifty-five 4-week-old female Wistar rats were allocated in 4 groups 1) ovariectomy control (OC), 2) ovariectomy-Anastrazole (OA) 3) ovariectomy -Letrozole (OL), 4) control. Serum glucose, cholesterol, triglycerides, HDL-c and LDL-c were measured at baseline, 2 and 4 months. At the end, the animals' liver were dissected for pathology. At 4 months, total cholesterol differed among the OC and OL groups (p = 0.15) and the control and OL groups (p = 0.12). LDL-C differed between the control and OC groups (p = 0.015) as well as between the control and OA (p =0 .015) and OL groups (p = 0.002). OC group triglycerides, differed from those of the OL group (p =0 .002) and the control group (p = 0.007). The OA also significantly differed from the OL (p = 0.50). Liver pathology analysis revealed differences among groups with favored mild steatosis and ballooning. Anastrazole and Letrozole seem to negatively influence the lipid profile in our experimental model. This information should be taken in caution by medical oncologists when addressing patients with altered lipid metabolism.
authors.affiliation: Second Department of Obstetrics and Gynecology, University of Athens, Vas. Sofias 76, Athens, 11528, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Boutas
authors.affiliation: Laboratory of Experimental Surgery and Surgical Research "N.S. Christeas", Athens Medical School, Agiou Thoma 15B, Athens, 11527, Greece.
authors.forename: Vasilios
authors.initials: V
authors.lastname: Pergialiotis
authors.affiliation: Second Department of Obstetrics and Gynecology, University of Athens, Vas. Sofias 76, Athens, 11528, Greece.
authors.forename: Nicolaos
authors.initials: N
authors.lastname: Salakos
authors.affiliation: First Department of Pathology, School of Medicine, National University of Athens, Mikras Asias 75str, Athens, 11527, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Agrogiannis
authors.affiliation: Laboratory of Experimental Surgery and Surgical Research "N.S. Christeas", Athens Medical School, Agiou Thoma 15B, Athens, 11527, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Konstantopoulos
authors.affiliation: Laboratory of Experimental Surgery and Surgical Research "N.S. Christeas", Athens Medical School, Agiou Thoma 15B, Athens, 11527, Greece.
authors.forename: Laskarina-Maria
authors.initials: LM
authors.lastname: Korou
authors.affiliation: Second Department of Obstetrics and Gynecology, University of Athens, Vas. Sofias 76, Athens, 11528, Greece.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Kalampokas
authors.affiliation: Second Department of Obstetrics and Gynecology, University of Athens, Vas. Sofias 76, Athens, 11528, Greece.
authors.forename: Odysseas
authors.initials: O
authors.lastname: Gregoriou
authors.affiliation: Second Department of Obstetrics and Gynecology, University of Athens, Vas. Sofias 76, Athens, 11528, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Creatsas
authors.affiliation: Laboratory of Experimental Surgery and Surgical Research "N.S. Christeas", Athens Medical School, Agiou Thoma 15B, Athens, 11527, Greece.
authors.forename: Despina
authors.initials: D
authors.lastname: Perrea
mesh_terms: D000077384:Anastrozole; D000818:Animals; D005260:Female; D000077289:Letrozole; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D009570:Nitriles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014230:Triazoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole; D000077289:Letrozole