title: Advances in Breast Cancer - Looking Back over the Year.
abstract: Treatment options as well as the characteristics for therapeutic decisions in patients with primary and advanced breast cancer are increasing in number and variety. New targeted therapies in combination with established chemotherapy schemes are broadening the spectrum, yet not every new, promising combination achieves a better result. New data from the field of pharmacogenomics point to prognostic and predictive factors that take not only the properties of the tumour but also the genetic disposition of the patient into consideration. Current therapeutic decision-making is thus based on a combination of classical clinical and modern molecular biomarkers. Health-economic concerns are also being taken into consideration more frequently, meaning political decisions may also become a factor. This review presents the trends over the past year.
authors.affiliation: Medizinische Klinik und Poliklinik II, Campus Charité Mitte, Berlin.
authors.forename: D
authors.initials: D
authors.lastname: Lüftner
authors.affiliation: Frauenklinik, Universitätsklinikum Erlangen, Erlangen.
authors.forename: M P
authors.initials: MP
authors.lastname: Lux
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Aachen.
authors.forename: N
authors.initials: N
authors.lastname: Maass
authors.affiliation: Frauenklinik, Universitätsklinikum Heidelberg, Heidelberg.
authors.forename: F
authors.initials: F
authors.lastname: Schütz
authors.affiliation: Klinik für Senologie/Brustzentrum, Klinikum Essen-Mitte, Essen.
authors.forename: I
authors.initials: I
authors.lastname: Schwidde
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen.
authors.forename: P A
authors.initials: PA
authors.lastname: Fasching
authors.affiliation: Department of Obstetrics and Gynecology, University Tübingen, Tübingen.
authors.forename: T
authors.initials: T
authors.lastname: Fehm
authors.affiliation: Frauenklinik, Klinikum der Universität Ulm, Ulm.
authors.forename: W
authors.initials: W
authors.lastname: Janni
authors.affiliation: Klinik für Senologie/Brustzentrum, Klinikum Essen-Mitte, Essen.
authors.forename: S
authors.initials: S
authors.lastname: Kümmel
authors.affiliation: Klinik für Gynäkologie und Geburtshilfe, Marienhospital Bottrop, Bottrop.
authors.forename: H-C
authors.initials: HC
authors.lastname: Kolberg
keywords: T-DM1; breast cancer therapy; everolimus; molecular biomarkers; targeted therapy; trastuzumab