title: Preoperative NT-proBNP values in patients with atrioventricular septal defect and its role as a predictor of early postoperative course.
abstract: OBJECTIVE
  Atrioventricular septal (AVSDC) defect presents by excessive pulmonary blood flow and congestive heart failure in children. This study was designed to identify and compare N-terminal pro-brain natriuretic peptide (NT-proBNP) values in complete and incomplete form at the time of surgery, and evaluation of postoperative course.
  
  
  METHODS
  The prospective study included thirty-one patients with complete and fifteen with intermediate forms, undergoing surgery in the period from May 2009 to January 2014. Pre- and post-operative variables were statistically analyzed.
  
  
  RESULTS
  The median value of NT-proBNP was 1420.0 pg/mL, with elevated levels in complete form (1656.0 vs 488.0 pg/mL, p < 0.001); age and weight with negative correlation. Other preoperative variables (genetic disorder, atrioventricular valve regurgitation, borderline ventricle) were not significant. Higher incidence of postoperative variables was present in complete form, namely mechanical ventilation (p < 0.03), dose and length of vasopressors (p < 0.002), ICU stay (p < 0.04), and complications (p < 0.05). NT-proBNP analysis as a predictor of postoperative course showed an association with longer ventilatory (> 48 hours) and inotropic forms of support, ICU stay, and presence of infection.
  
  
  CONCLUSIONS
  NT-proBNP value might be helpful in the decision-making process of early surgical treatment of complete form of AVSDC, and useful as a predictor of early post-operative course (Tab. 4, Fig. 3, Ref. 14).
authors.forename: L
authors.initials: L
authors.lastname: Bobik
authors.forename: L
authors.initials: L
authors.lastname: Kovacikova
authors.forename: M
authors.initials: M
authors.lastname: Zahorec
authors.forename: K
authors.initials: K
authors.lastname: Danova
mesh_terms: D015415:Biomarkers / Q000097:blood; D002675:Child, Preschool; D005260:Female; D006343:Heart Septal Defects / Q000097:blood* / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011184:Postoperative Period; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: NT-proBNP; atrioventricular septal defect; congestive heart failure; postoperative course.