title: CardioGenBase: A Literature Based Multi-Omics Database for Major Cardiovascular Diseases.
abstract: Cardiovascular diseases (CVDs) account for high morbidity and mortality worldwide. Both, genetic and epigenetic factors are involved in the enumeration of various cardiovascular diseases. In recent years, a vast amount of multi-omics data are accumulated in the field of cardiovascular research, yet the understanding of key mechanistic aspects of CVDs remain uncovered. Hence, a comprehensive online resource tool is required to comprehend previous research findings and to draw novel methodology for understanding disease pathophysiology. Here, we have developed a literature-based database, CardioGenBase, collecting gene-disease association from Pubmed and MEDLINE. The database covers major cardiovascular diseases such as cerebrovascular disease, coronary artery disease (CAD), hypertensive heart disease, inflammatory heart disease, ischemic heart disease and rheumatic heart disease. It contains ~1,500 cardiovascular disease genes from ~2,4000 research articles. For each gene, literature evidence, ontology, pathways, single nucleotide polymorphism, protein-protein interaction network, normal gene expression, protein expressions in various body fluids and tissues are provided. In addition, tools like gene-disease association finder and gene expression finder are made available for the users with figures, tables, maps and venn diagram to fit their needs. To our knowledge, CardioGenBase is the only database to provide gene-disease association for above mentioned major cardiovascular diseases in a single portal. CardioGenBase is a vital online resource to support genome-wide analysis, genetic, epigenetic and pharmacological studies.
authors.affiliation: Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603 103, Tamil Nadu, India.
authors.forename: Alexandar
authors.initials: A
authors.lastname: V
authors.affiliation: Department of Cardiology, Chettinad Super Specialty Hospital, Chettinad Academy of Research and Education, Kelambakkam 603 103, Tamil Nadu, India.
authors.forename: Pradeep G
authors.initials: PG
authors.lastname: Nayar
authors.affiliation: Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603 103, Tamil Nadu, India.
authors.forename: R
authors.initials: R
authors.lastname: Murugesan
authors.affiliation: Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603 103, Tamil Nadu, India.
authors.forename: Beaulah
authors.initials: B
authors.lastname: Mary
authors.affiliation: Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603 103, Tamil Nadu, India.
authors.forename: Darshana
authors.initials: D
authors.lastname: P
authors.affiliation: Department of Computational Biology, Drug discovery Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, 603 103, Tamil Nadu, India.
authors.forename: Shiek S S J
authors.initials: SS
authors.lastname: Ahmed
mesh_terms: D001682:Biological Availability; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000235:genetics*; D002877:Chromosomes, Human / Q000235:genetics; D030541:Databases, Genetic; D063990:Gene Ontology; D006801:Humans; D016239:MEDLINE; D020641:Polymorphism, Single Nucleotide; D060066:Protein Interaction Maps; D059467:Transcriptome