title: Correlation between VEGFR2 rs2071559 polymorphism and glioma risk among Chinese population.
abstract: OBJECTIVE
  We investigated the correlation between vascular endothelial growth factor 2 (VEGFR2) polymorphism and glioma risk among Chinese population.
  
  
  METHODS
  Case-control study design was adopted, and blood samples and clinical data of 250 glioma cases and 260 control subjects were collected. Epidemiological questionnaire survey was performed, and DNA extraction, concentration normalization and packaging were carried out using Qiagen Blood Kit. TaqMan method was performed for VEGFR2 rs2071559 genotyping.
  
  
  RESULTS
  C allele of VEGFR2 rs2071559 genotype was the susceptibility allele contributing to the risk of glioma (OR=1.813, 95% CI: 1.393-2.359, P=0.014). CC genotypes of VEGFR2 rs2071559 were associated with increased risk of glioma (OR=2.068, 95% CI: 1.164-3.674, P=0.014; Adjusted OR=1.883, 95% CI: 1.430~3.013, P=0.018).
  
  
  CONCLUSIONS
  CC genotypes of VEGFR2 rs2071559 were associated with glioma risk among Chinese population. However, the role of VEGFR2 rs2071559 polymorphism in glioma susceptibility remains to be further clarified.
authors.affiliation: Department of Neurosurgery, Wuhan General Hospital of Guangzhou Command, Hubei Key Laboratory of Central Nervous System Tumor and Intervention Wuhan 430070, China.
authors.forename: Guo-Zheng
authors.initials: GZ
authors.lastname: Xu
authors.affiliation: Department of Clinical Laboratory, Wuhan General Hospital of Guangzhou Command Wuhan 430070, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Clinical Experiment, Wuhan General Hospital of Guangzhou Command Wuhan 430070, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Clinical Experiment, Wuhan General Hospital of Guangzhou Command Wuhan 430070, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, Wuhan General Hospital of Guangzhou Command, Hubei Key Laboratory of Central Nervous System Tumor and Intervention Wuhan 430070, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Diao
keywords: Glioma; gene; genetics; polymorphism; vascular endothelial growth factor 2 (VEGFR2)