title: Multilayered Graphene Nano-Film for Controlled Protein Delivery by Desired Electro-Stimuli.
abstract: Recent research has highlighted the potential use of "smart" films, such as graphene sheets, that would allow for the controlled release of a variety of therapeutic drugs. Taking full advantage of these versatile conducting sheets, we investigated the novel concept of applying graphene oxide (GO) and reduced graphene oxide (rGO) materials as both barrier and conducting layers that afford controlled entrapment and release of any molecules of interest. We fabricated multilayered nanofilm architectures using a hydrolytically degradable cationic poly(β-amino ester) (PAE), a model protein antigen, ovalbumin (OVA) as a building block along with the GO and rGO. We successfully showed that these multilayer films are capable of blocking the initial burst release of OVA, and they can be triggered to precisely control the release upon the application of electrochemical potential. This new drug delivery platform will find its usefulness in various transdermal drug delivery devices where on-demand control of drug release from the surface is necessary.
authors.affiliation: School of Chemical Engineering &Materials Science, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Moonhyun
authors.initials: M
authors.lastname: Choi
authors.affiliation: School of Mechanical Engineering, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors.forename: Kyung-Geun
authors.initials: KG
authors.lastname: Kim
authors.affiliation: School of Chemical Engineering &Materials Science, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Jiwoong
authors.initials: J
authors.lastname: Heo
authors.affiliation: School of Chemical Engineering &Materials Science, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Hyejoong
authors.initials: H
authors.lastname: Jeong
authors.affiliation: School of Mechanical Engineering, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors.forename: Sung Yeol
authors.initials: SY
authors.lastname: Kim
authors.affiliation: School of Chemical Engineering &Materials Science, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Jinkee
authors.initials: J
authors.lastname: Hong
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry; D055664:Electrochemical Techniques; D006108:Graphite / Q000737:chemistry*; D008567:Membranes, Artificial; D049329:Nanostructures / Q000737:chemistry*; D010047:Ovalbumin / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; D006108:Graphite; D010047:Ovalbumin