title: L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles.
abstract: Manganese oxide nanoparticles (MONPs) are capable of time-dependent magnetic resonance imaging contrast switching as well as releasing a surface-bound drug. MONPs give T2/T2* contrast, but dissolve and release T1-active Mn(2+) and L-3,4-dihydroxyphenylalanine. Complementary images are acquired with a single contrast agent, and applications toward Parkinson's disease are suggested.
authors.affiliation: Uglestad Laboratory, Department of Chemical Engineering, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
authors.forename: Birgitte Hjelmeland
authors.initials: BH
authors.lastname: McDonagh
authors.affiliation: Department of Materials Science and Engineering, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
authors.forename: Gurvinder
authors.initials: G
authors.lastname: Singh
authors.affiliation: Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
authors.forename: Sjoerd
authors.initials: S
authors.lastname: Hak
authors.affiliation: Uglestad Laboratory, Department of Chemical Engineering, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
authors.forename: Sulalit
authors.initials: S
authors.lastname: Bandyopadhyay
authors.affiliation: Department of Neuroscience, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
authors.forename: Ingrid Lovise
authors.initials: IL
authors.lastname: Augestad
authors.affiliation: Institute of Structure and Matter, National Research Council, 00015, Monterotondo, Scalo, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Peddis
authors.affiliation: Department of Neuroscience, Norwegian University of Science and Technology, 7491, Trondheim, Norway.|John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, CB2 OPY, Cambridge, UK.
authors.forename: Ioanna
authors.initials: I
authors.lastname: Sandvig
authors.affiliation: Department of Neuroscience, Norwegian University of Science and Technology, 7491, Trondheim, Norway.|Division of Pharmacology and Clinical Neurosciences, Department of Neurosurgery, Umeå University, 901 87, Umeå, Sweden.
authors.forename: Axel
authors.initials: A
authors.lastname: Sandvig
authors.affiliation: Uglestad Laboratory, Department of Chemical Engineering, Norwegian University of Science and Technology, 7491, Trondheim, Norway.|Sector for Biotechnology and Nanomedicine, SINTEF Materials and Chemistry, 7465, Trondheim, Norway.
authors.forename: Wilhelm Robert
authors.initials: WR
authors.lastname: Glomm
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D007980:Levodopa / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D017895:Manganese Compounds / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry*; D051381:Rats; D034421:Sus scrofa; D014867:Water / Q000737:chemistry
chemical_list: D020099:Coated Materials, Biocompatible; D003287:Contrast Media; D017895:Manganese Compounds; D010087:Oxides; D014867:Water; D007980:Levodopa; C027424:manganese oxide
keywords: MRI; contrast agents; drug delivery; l-DOPA; manganese; manganese oxide