title: Isomaltodextrin, a highly branched α-glucan, increases rat colonic H₂ production as well as indigestible dextrin.
abstract: Colonic hydrogen (H2) protects against inflammation-induced oxidative stress. We examined the effect of a new highly branched α-glucan, isomaltodextrin (IMD), on colonic H2 production in rats. Rats were fed a 16.7% IMD, 8.8% indigestible dextrin (ID), or 10.4% high amylose cornstarch diet (Expt. 1), were fed diets containing 3.3-16.7% IMD (Expt. 2), or were fed diets containing 16.7% IMD or 5.2% fructooligosaccharide (FOS) (Expt. 3), for 14 days. Compared with the control group, feeding IMD or other α-glucans dose dependently and significantly increased H2 excretion and portal H2 concentration. The ability of IMD to increase H2 production was not inferior to that of FOS. The cecal Firmicutes/Bacteroidetes ratio in the IMD group was 5-14% of that in the control group. The cecal abundance of bifidobacteria was significantly greater in the IMD group than in the control group. Taken together, IMD, as well as other α-glucans, significantly increased colonic H2 production in a dose-dependent manner.
authors.affiliation: a Faculty of Health and Welfare Science, Department of Nutritional Sciences , Nayoro City University , Nayoro , Japan.|b College of Agriculture, Academic Institute, Shizuoka University , Shizuoka , Japan.
authors.forename: Naomichi
authors.initials: N
authors.lastname: Nishimura
authors.affiliation: a Faculty of Health and Welfare Science, Department of Nutritional Sciences , Nayoro City University , Nayoro , Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tanabe
authors.affiliation: a Faculty of Health and Welfare Science, Department of Nutritional Sciences , Nayoro City University , Nayoro , Japan.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D003106:Colon / Q000187:drug effects* / Q000378:metabolism; D003912:Dextrins / Q000378:metabolism*; D006859:Hydrogen; D008297:Male; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003912:Dextrins; D011134:Polysaccharides; C008315:maltodextrin; D006859:Hydrogen
keywords: colonic fermentation; hydrogen gas; isomaltodextrin; large intestine; rats