title: A standardized diagnostic approach and ongoing feedback improves outcome in psychogenic nonepileptic seizures.
abstract: BACKGROUND
  Psychogenic nonepileptic seizures (PNES) are episodic alterations in behavior presumed to reflect a physical manifestation of underlying psychological distress. Standardized treatment approaches for PNES care are lacking. We evaluated common approaches to PNES management that do not require significant commitment of time and resources.
  
  
  METHODS
  Patients with PNES established with video-EEG monitoring were randomized to one of the following three groups: 1) PNES diagnosis delivered per the discretion of the attending physician with advice to seek mental health assistance in the community (n=12), 2) scripted PNES diagnosis provided and inpatient psychiatry consult obtained (n=10), and 3) weekly follow-up phone calls made in addition to scripted diagnosis and inpatient psychiatry consultation (n=15). Reduction in event frequency measured at 8weeks following hospital discharge represented the primary outcome variable. Secondary variables analyzed included exploration of change in self-reported mood, quality of life, and healthcare utilization.
  
  
  RESULTS
  No significant improvements were noted in patients simply given a PNES diagnosis and advised to seek outside care on any measure. In contrast, patients receiving a scripted diagnosis and psychiatric consultation demonstrated decreased PNES frequency accompanied by improved quality of life (QOL). Patients also receiving weekly phone calls not only demonstrated decreased PNES frequency and improvements in QOL but also exhibited improved mood.
  
  
  CONCLUSIONS
  These findings demonstrate that providing diagnostic information regarding PNES is insufficient by itself to meaningfully affect patient outcome. Structured feedback and psychiatric consultation appeared adequate to significantly reduce PNES frequency and improve aspects of quality of life, while the addition of a weekly phone contact also led to improved mood.
authors.affiliation: Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: ddrane@emory.edu.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Drane
authors.affiliation: Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Suzette M
authors.initials: SM
authors.lastname: LaRoche
authors.affiliation: Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA; Department of Neurology, Atlanta Veterans Administration Medical Center, Decatur, GA, USA.
authors.forename: Geeta A
authors.initials: GA
authors.lastname: Ganesh
authors.affiliation: Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Diane
authors.initials: D
authors.lastname: Teagarden
authors.affiliation: Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Loring
mesh_terms: D000328:Adult; D000339:Affect; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011602:Psychophysiologic Disorders / Q000175:diagnosis* / Q000523:psychology; D011788:Quality of Life; D012640:Seizures / Q000175:diagnosis* / Q000523:psychology; D055815:Young Adult
keywords: Mental health; Outcome; Psychogenic nonepileptic seizures; Treatment intervention