title: Forced expiratory volume in one second can predict SYNTAX score in patients with chronic obstructive pulmonary disease.
abstract: BACKGROUND
  The SYNTAX score is an angiographic score that predicts coronary artery disease (CAD) complexity. It has been shown to be useful for decision making about percutaneous coronary intervention or coronary artery bypass grafting among patients with CAD. Higher SYNTAX scores are indicative of more complex disease. Chronic obstructive pulmonary disease (COPD) is characterised by limitation of airflow. Measurement of forced expiratory volume in one second (FEV1) in spirometry is used for diagnosis and to determine the severity of the disease.
  
  
  OBJECTIVE
  To evaluate the relationship between FEV1 and SYNTAX score in patients with COPD.
  
  
  METHODS
  Seventy-eight patients with a previous diagnosis of COPD and 48 patients without COPD were enrolled. Spirometry and coronary angiography were performed in all patients. SYNTAX score was calculated and compared between the two groups. The correlation between FEV1 and SYNTAX score was analysed.
  
  
  RESULTS
  SYNTAX score was higher in patients with COPD than in patients without COPD (23.22 ± 12.10 vs. 17.92 ± 11.21, respectively; p = 0.013). Multivariate analysis demonstrated that COPD was independently predictive for intermediate and high SYNTAX score (odds ratio 4.833; 95% confidence interval 2.228-10.485; p < 0.001). Mean FEV1 (% predicted) was 64.7 ± 11.4 and negatively correlated with SYNTAX score in COPD group (r = -0.266 and p = 0.018). The receiver operating characteristic analysis yielded a cutoff value of 65.5 for the FEV1 to predict SYNTAX score ≥ 23, with sensitivity and specificity being 78.6% and 70%, respectively.
  
  
  CONCLUSIONS
  COPD is a predictor of higher SYNTAX scores. FEV1 is associated with more severe and complex CAD.
authors.affiliation: Deparment of Cardiology, Ankara Training and Research Hospital, Ankara, Turkey. drcemalkoseoglu@hotmail.com.
authors.forename: Cemal
authors.initials: C
authors.lastname: Koseoglu
authors.forename: Ozge
authors.initials: O
authors.lastname: Kurmus
authors.forename: Ahmet Goktug
authors.initials: AG
authors.lastname: Ertem
authors.forename: Busra
authors.initials: B
authors.lastname: Colak
authors.forename: Ozgur
authors.initials: O
authors.lastname: Kırbas
authors.forename: Emine
authors.initials: E
authors.lastname: Bilen
authors.forename: Tahir
authors.initials: T
authors.lastname: Durmaz
authors.forename: Telat
authors.initials: T
authors.lastname: Keles
authors.forename: Engin
authors.initials: E
authors.lastname: Bozkurt
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications*; D012372:ROC Curve
keywords: SYNTAX score; chronic obstructive pulmonary disease; forced expiratory volume in one second