title: Soluble receptor for advanced glycation end products and increased aortic stiffness in the general population.
abstract: It has been suggested that accumulation of advanced glycation end products (AGEs) is involved in several pathophysiological processes in the vessel wall. We hypothesized that low levels of the soluble receptor for AGEs (sRAGE) might be associated with increased arterial stiffness, a manifestation of vascular ageing in the general population. Using a cross-sectional design, we analyzed 1077 subjects from the Czech post-MONICA study. The aortic pulse wave velocity (aPWV) was measured using a Sphygmocor device. sRAGE concentrations were assessed in frozen samples using enzyme-linked immunosorbent assay methods (R&D Systems). aPWV significantly (P<0.0001) increased across the sRAGE quartiles. An aPWV of 1 m s(-1) was associated with a 37% increase in the risk of low sRAGE (<918 pg ml(-1), bottom quartile; P-value=0.018). In a categorized manner, subjects in the bottom sRAGE quartile had an odds ratio of an increased aPWV (⩾9.3 m s(-1)), adjusted for all potential confounders of 2.05 (95% confidence interval: 1.26-3.32; P=0.004), but this was only the case for non-diabetic hypertensive patients. In contrast, a low sRAGE was rejected as an independent predictor of an increased aPWV in normotensive or diabetic subjects using similar regression models. In conclusion, low circulating sRAGE was independently associated with increased arterial stiffness in a general population-based sample, but this was only observed in hypertensive non-diabetic patients.
authors.affiliation: Second Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic.|Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic.
authors.forename: Otto
authors.initials: O
authors.lastname: Mayer
authors.affiliation: Second Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic.|Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic.
authors.forename: Jitka
authors.initials: J
authors.lastname: Seidlerová
authors.affiliation: Second Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic.|Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Filipovský
authors.affiliation: Second Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic.|Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic.
authors.forename: Petra
authors.initials: P
authors.lastname: Vágovičová
authors.affiliation: Centre for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic.|International Clinical Research Centre, St Anne's University Hospital, Brno, Czech Republic.
authors.forename: Peter
authors.initials: P
authors.lastname: Wohlfahrt
authors.affiliation: Centre for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic.|International Clinical Research Centre, St Anne's University Hospital, Brno, Czech Republic.
authors.forename: Renata
authors.initials: R
authors.lastname: Cífková
authors.affiliation: Department of Immunodiagnostics, University Hospital, Pilsen, Czech Republic.
authors.forename: Jindra
authors.initials: J
authors.lastname: Windrichová
authors.affiliation: Department of Immunodiagnostics, University Hospital, Pilsen, Czech Republic.|Czech Republic of Clinical Biochemistry and Hematology, University Hospital, Pilsen, Czech Republic.
authors.forename: Ondřej
authors.initials: O
authors.lastname: Topolčan
mesh_terms: D000328:Adult; D000368:Aged; D001011:Aorta / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology*; D003430:Cross-Sectional Studies; D018153:Czech Republic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D000067759:Receptor for Advanced Glycation End Products / Q000097:blood*; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: D000067759:Receptor for Advanced Glycation End Products