title: Vaccine strategies against cystic fibrosis pathogens.
abstract: A great number of cystic fibrosis (CF) pathogens such as Pseudomonas aeruginosa, the Burkholderia cepacia and the Mycobacterium abscessus complex raised difficult therapeutic problems due to their intrinsic multi-resistance to numerous antibiotics. Vaccine strategies represent one of the key weapons against these multi-resistant bacteria in a number of clinical settings like CF. Different strategies are considered in order to develop such vaccines, linked either to priming the host response, or by exploiting genomic data derived from the bacterium. Interestingly, virulence factors synthesized by various pathogens might serve as targets for vaccine development and have been, for example, evaluated in the context of CF.
authors.affiliation: a INSERM U1173, UFR Des Sciences de la Santé Simone Veil, Université de Versailles-Saint-Quentin , Saint-Quentin en Yvelines , France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Le Moigne
authors.affiliation: a INSERM U1173, UFR Des Sciences de la Santé Simone Veil, Université de Versailles-Saint-Quentin , Saint-Quentin en Yvelines , France.|b Service de Microbiologie, Groupe Hospitalier et Universitaire Paris Île-de-France Ouest, Assitance Publique Hôpitaux de Paris, (92) Boulogne-Billancourt and Garches , France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Gaillard
authors.affiliation: a INSERM U1173, UFR Des Sciences de la Santé Simone Veil, Université de Versailles-Saint-Quentin , Saint-Quentin en Yvelines , France.|b Service de Microbiologie, Groupe Hospitalier et Universitaire Paris Île-de-France Ouest, Assitance Publique Hôpitaux de Paris, (92) Boulogne-Billancourt and Garches , France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Herrmann
mesh_terms: D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D016956:Burkholderia cepacia / Q000276:immunology; D003550:Cystic Fibrosis / Q000150:complications*; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D006801:Humans; D009161:Mycobacterium / Q000276:immunology; D018410:Pneumonia, Bacterial / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines
keywords: Burkholderia spp.; Mycobacterium abscessus; Pseudomonas aeruginosa; cystic fibrosis; vaccine