title: Juvenile idiopathic arthritis activity and function ability: deleterious effects in periodontal disease?
abstract: The impact of juvenile idiopathic arthritis (JIA) in periodontal diseases is controversial probably due to gender and age heterogeneity. We therefore evaluated a homogeneous female post-pubertal JIA population for these conditions. Thirty-five JIA patients and 35 gender/age comparable healthy controls were evaluated according to demographic data, complete periodontal evaluation, fasting lipoproteins, and anti-lipoprotein lipase antibodies. JIA scores, laboratorial tests, X-rays, and treatment were also assessed. Current age was similar in JIA patients and controls (11.90 ± 2.0 vs. 12.50 ± 3.0 years, p = 0.289). Complete periodontal assessments revealed that gingival index, dental plaque, gingival bleeding, and clinical dental attachment indices were alike in JIA patients and controls (p > 0.05), except for gingival enlargement in former group (p < 0.0001). Further analysis of patients with and without gingivitis revealed that cyclosporine use was more often observed in JIA patients with gingivitis (37 vs. 0%, p = 0.01), whereas no differences were evidenced in demographic, JIA scores, inflammatory markers, and lipid profile in both groups. Of note, two parameters of periodontal assessment were correlated with JIA scores [gingival index (GI) and Childhood Health Assessment Questionnaire (CHAQ) (r s  = +0.402, p = 0.020)] and plaque index (PI) and visual analog scale (VAS) physician (r s  = +0.430, p = 0.013). In addition, evaluation of dental assessment demonstrated that JIA activity scores had positive correlation with decayed, missing, and filled teeth (DMF-T) and junvenile athritis disease activity score (JADAS) (r s  = +0.364,p = 0.037), VAS physician (r s  = +0.401,p = 0.021) and VAS patient (r s  = +0.364,p = 0.037). We demonstrated, using rigorous criteria, that periodontal and dental condition in JIA is similar to controls. In spite of that, the finding of a correlation with disease parameters provides additional evidence that increased activity and reduced functional ability underlies the deleterious effect of JIA in oral health.
authors.affiliation: Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Eneas Carvalho Aguiar, 647 - Cerqueira César, São Paulo, SP, 05403-000, Brazil.
authors.forename: Camila
authors.initials: C
authors.lastname: Pugliese
authors.affiliation: Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Eneas Carvalho Aguiar, 647 - Cerqueira César, São Paulo, SP, 05403-000, Brazil.
authors.forename: Roberta T A
authors.initials: RT
authors.lastname: van der Vinne
authors.affiliation: Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Eneas Carvalho Aguiar, 647 - Cerqueira César, São Paulo, SP, 05403-000, Brazil.
authors.forename: Lucia M A
authors.initials: LM
authors.lastname: Campos
authors.affiliation: Division of Dentistry, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Eneas Carvalho Aguiar, 647 - Cerqueira César, São Paulo, SP, 05403-000, Brazil.
authors.forename: Priscila R
authors.initials: PR
authors.lastname: Guardieiro
authors.affiliation: Division of Dentistry, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Eneas Carvalho Aguiar, 647 - Cerqueira César, São Paulo, SP, 05403-000, Brazil.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Saviolli
authors.affiliation: Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Eneas Carvalho Aguiar, 647 - Cerqueira César, São Paulo, SP, 05403-000, Brazil.
authors.forename: Eloisa
authors.initials: E
authors.lastname: Bonfá
authors.affiliation: Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Eneas Carvalho Aguiar, 647 - Cerqueira César, São Paulo, SP, 05403-000, Brazil.
authors.forename: Rosa M R
authors.initials: RM
authors.lastname: Pereira
authors.affiliation: Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Eneas Carvalho Aguiar, 647 - Cerqueira César, São Paulo, SP, 05403-000, Brazil.
authors.forename: Vilma S
authors.initials: VS
authors.lastname: Viana
authors.affiliation: Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Eneas Carvalho Aguiar, 647 - Cerqueira César, São Paulo, SP, 05403-000, Brazil.
authors.forename: Eduardo F
authors.initials: EF
authors.lastname: Borba
authors.affiliation: Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Eneas Carvalho Aguiar, 647 - Cerqueira César, São Paulo, SP, 05403-000, Brazil. clovisaasilva@gmail.com.|Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Eneas Carvalho Aguiar, 647 - Cerqueira César, São Paulo, SP, 05403-000, Brazil. clovisaasilva@gmail.com.
authors.forename: Clovis A
authors.initials: CA
authors.lastname: Silva
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000906:Antibodies / Q000097:blood; D001171:Arthritis, Juvenile / Q000150:complications*; D001938:Brazil; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000150:complications; D005260:Female; D005891:Gingivitis / Q000150:complications*; D006801:Humans; D008055:Lipids / Q000097:blood; D009043:Motor Activity; D010147:Pain Measurement; D010510:Periodontal Diseases / Q000150:complications*; D012720:Severity of Illness Index
chemical_list: D000906:Antibodies; D008055:Lipids
keywords: Anti-lipoprotein lipase antibodies; Dyslipidemia; Gingivitis; Juvenile idiopathic arthritis; Periodontal