title: Aripiprazole Can Improve Apraxia of Eyelid Opening in Parkinson's Disease.
abstract: We herein report three cases of Parkinson's disease associated with difficulty in eyelid opening, referred to as apraxia of eyelid opening (AEO), which improved after aripiprazole treatment. In case 1, aripiprazole was administered as a psychiatric treatment. It proved to be effective in AEO with blepharospasm. In case 2 and case 3, the patients experienced AEO without blepharospasm, and a significant improvement was observed after aripiprazole treatment. In this study, the aripiprazole dosage ranged between 3 and 9 mg/day. This is the first report of aripiprazole as a potentially effective treatment for AEO in Parkinson's disease.
authors.affiliation: The Department of Neurology, Kumamoto Kinoh Hospital, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Tokisato
authors.forename: Kimiko
authors.initials: K
authors.lastname: Fukunaga
authors.forename: Makoto
authors.initials: M
authors.lastname: Tokunaga
authors.forename: Susumu
authors.initials: S
authors.lastname: Watanabe
authors.forename: Ryoji
authors.initials: R
authors.lastname: Nakanishi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yamanaga
mesh_terms: D001072:Apraxias / Q000188:drug therapy* / Q000209:etiology; D000068180:Aripiprazole / Q000008:administration & dosage*; D001764:Blepharospasm / Q000188:drug therapy* / Q000209:etiology; D005143:Eyelids / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000068180:Aripiprazole