title: Pulled Polymer Loops as a Model for the Alignment of Meiotic Chromosomes.
abstract: During recombination, the DNA of parents exchange their genetic information to give rise to a genetically unique offspring. For recombination to occur, homologous chromosomes need to find each other and align with high precision. Fission yeast solves this problem by folding chromosomes in loops and pulling them through the viscous nucleoplasm. We propose a theory of pulled polymer loops to quantify the effect of drag forces on the alignment of chromosomes. We introduce an external force field to the concept of a Brownian bridge and thus solve for the statistics of loop configurations in space.
authors.affiliation: Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, D-01187 Dresden, Germany.
authors.forename: Yen Ting
authors.initials: YT
authors.lastname: Lin
authors.affiliation: Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, D-01187 Dresden, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Frömberg
authors.affiliation: Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, D-01187 Dresden, Germany.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Huang
authors.affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D-01307 Dresden, Germany.
authors.forename: Petrina
authors.initials: P
authors.lastname: Delivani
authors.affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D-01307 Dresden, Germany.
authors.forename: Mariola
authors.initials: M
authors.lastname: Chacón
authors.affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D-01307 Dresden, Germany.|Division of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia.
authors.forename: Iva M
authors.initials: IM
authors.lastname: Tolić
authors.affiliation: Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, D-01187 Dresden, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Jülicher
authors.affiliation: Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, D-01187 Dresden, Germany.
authors.forename: Vasily
authors.initials: V
authors.lastname: Zaburdaev
mesh_terms: D015825:Chromosomes, Fungal; D008540:Meiosis / Q000235:genetics*; D008957:Models, Genetic; D012568:Schizosaccharomyces / Q000166:cytology* / Q000235:genetics* / Q000648:ultrastructure