title: Recent prospective of nanofiber scaffolds fabrication approaches for skin regeneration.
abstract: The largest organ of human body is skin, which acting as a barrier with immunologic, sensorial and protective functions. It is always in exposure to the external environment, which can result many different types of damage and injury with loss of variable volumes of extracellular matrix (ECM). For the treatment of skin lesions and damages, several approaches are now accessible, such as the application of allografts, autografts, and tissue-engineered substitutes, wound dressings and nanofiber scaffolds approaches. Even though proven clinically effective, these methods are still characterized by main drawbacks such as patient inadequate vascularization, morbidity, the inability to reproduce skin appendages, low adherence to the wound bed and high manufacturing costs. Advanced approaches based on nanofiber scaffolds approaches offer a permanent, viable and effective substitute to explain the drawbacks of skin regeneration and repair by combining growth factors, cells, and biomaterials and advanced biomanufacturing methods. This review details recent advances of nanofiber scaffolds in skin regeneration and repair strategies, and describes a synthesis method of nanofiber scaffolds.
authors.affiliation: a Department of Medical Biotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.|b Iran National Science Foundations: INSF , Tehran , Iran.|c Student Research Committee, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Fateme
authors.initials: F
authors.lastname: Ahmadi-Aghkand
authors.affiliation: b Iran National Science Foundations: INSF , Tehran , Iran.|c Student Research Committee, Tabriz University of Medical Sciences , Tabriz , Iran.|d Department of Molecular Medicine , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.|e Drugs Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|f Iran Nanotechnology Initiative Council (INIC) , Tehran , Iran.
authors.forename: Shiva
authors.initials: S
authors.lastname: Gholizadeh-Ghaleh Aziz
authors.affiliation: g Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences , Tehran , Iran.
authors.forename: Yunes
authors.initials: Y
authors.lastname: Panahi
authors.affiliation: a Department of Medical Biotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.|b Iran National Science Foundations: INSF , Tehran , Iran.|c Student Research Committee, Tabriz University of Medical Sciences , Tabriz , Iran.|f Iran Nanotechnology Initiative Council (INIC) , Tehran , Iran.
authors.forename: Hadis
authors.initials: H
authors.lastname: Daraee
authors.affiliation: e Drugs Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|h Biotechnology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Fateme
authors.initials: F
authors.lastname: Gorjikhah
authors.affiliation: f Iran Nanotechnology Initiative Council (INIC) , Tehran , Iran.|j Laboratory of Biochemistry , Department of Biology, Faculty of Natural Sciences, University of Tabriz , Tabriz , Iran.|k Department of Food Science and Technology , Islamic Azad University of Tabriz , Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Gholizadeh-Ghaleh Aziz
authors.affiliation: j Laboratory of Biochemistry , Department of Biology, Faculty of Natural Sciences, University of Tabriz , Tabriz , Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Hsanzadeh
authors.affiliation: b Iran National Science Foundations: INSF , Tehran , Iran.|c Student Research Committee, Tabriz University of Medical Sciences , Tabriz , Iran.|g Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences , Tehran , Iran.|h Biotechnology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|i Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D057139:Nanofibers / Q000737:chemistry*; D012038:Regeneration; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D012879:Skin Physiological Phenomena; D054457:Tissue Scaffolds / Q000737:chemistry*
keywords: Nanofiber; scaffolds; skin regeneration; tissue engineering; wound healing