title: Influence of Dietary Copper on Serum Growth-Related Hormone Levels and Growth Performance of Weanling Pigs.
abstract: To investigate the effect of dietary copper on serum growth-related hormones levels and growth performance, a total of 60 weanling pigs were randomly assigned to six groups each containing 10 pigs, fed on basal diets supplemented with 0 (control), 100, 150, 200, 250, and 300 mg/kg copper sulfate for 80 days, respectively. The average daily gain (ADG), feed to gain ratio (F/G), feed intake and serum growth hormone (GH), insulin (INS), insulin-like growth factor 1 (IGF-1), and insulin-like growth factor-binding protein 3 (IGFBP-3) levels were detected at interval of 20 days. The results revealed that ADG, and serum GH, INS, IGF-1, and IGFBP-3 concentrations were increased significantly in the pigs fed on diets added with 100, 150, 200, 250, and 300 mg/kg copper sulfate. Meanwhile, in the pigs supplemented with 250 mg/kg copper sulfate, ADG was increased significantly from the 40th to the 60th day of the experiment (P < 0.01), and the levels of GH, INS, IGF-1, and IGFBP-3 in serum were elevated significantly from the 20th to the 40th day of the experiment (P < 0.01). It is concluded that effects of copper supplemented in the diet on the growth of pigs were related to the increasing levels of GH, INS, IGF-1, and IGFBP-3 in serum which were induced by copper. High dietary copper increase the concentrations of growth-related hormones in serum, resulting in improving the growth performance of weanling pigs.
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wang
authors.affiliation: UMR 1195 Inserm and University Paris-Saclay, Saclay, Kremlin-Bicêtre, France.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhu
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi, China.
authors.forename: Yazhou
authors.initials: Y
authors.lastname: Guo
authors.affiliation: College of Veterinary Medicine, Jilin University, Changchun, 130062, Jilin, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wang
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi, China. zhaobaoyu12005@163.com.
authors.forename: Baoyu
authors.initials: B
authors.lastname: Zhao
authors.affiliation: Guizhou Minzu University, Guiyang, 550025, China. yunhouyin@sina.com.
authors.forename: Yunhou
authors.initials: Y
authors.lastname: Yin
authors.affiliation: College of Veterinary Medicine, Jilin University, Changchun, 130062, Jilin, China. liuguowen2008@163.com.
authors.forename: Guowen
authors.initials: G
authors.lastname: Liu
mesh_terms: D000818:Animals; D003300:Copper / Q000008:administration & dosage / Q000494:pharmacology*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D013006:Growth Hormone / Q000097:blood*; D013552:Swine / Q000254:growth & development*; D014886:Weaning; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D003300:Copper; D013006:Growth Hormone
keywords: Dietary copper; Growth hormone; Growth performance; Insulin-like growth factor; Pigs