title: Knee pain, knee injury, knee osteoarthritis & work.
abstract: Symptomatic knee osteoarthritis (OA) can be viewed as the end result of a molecular cascade which ensues after certain triggers occur and ultimately results in irreversible damage to the articular cartilage. The clinical phenotype that knee OA can produce is variable and often difficult to accurately predict. This is further complicated by the often poor relationship between radiographic OA and knee pain. As a consequence, it can be difficult to compare studies that use different definitions of OA. However, the literature suggests that while there are multiple causes of knee OA, two have attracted particular attention over recent years; occupation related knee OA and OA subsequent to previous knee injury. The evidence of a relationship, and the strength of this association, is discussed in this chapter.
authors.affiliation: University Hospitals Trust, Southampton, UK. Electronic address: gurdeepdulay@hotmail.com.
authors.forename: Gurdeep S
authors.initials: GS
authors.lastname: Dulay
authors.affiliation: MRC Lifecourse Epidemiology Unit, University of Southampton, UK; NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK. Electronic address: cc@mrc.soton.ac.uk.
authors.forename: C
authors.initials: C
authors.lastname: Cooper
authors.affiliation: MRC Lifecourse Epidemiology Unit, University of Southampton, UK; Victoria University, Wellington, New Zealand. Electronic address: emd@mrc.soton.ac.uk.
authors.forename: E M
authors.initials: EM
authors.lastname: Dennison
mesh_terms: D005260:Female; D006801:Humans; D007718:Knee Injuries / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008297:Male; D059352:Musculoskeletal Pain / Q000175:diagnosis / Q000209:etiology*; D009784:Occupational Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D016273:Occupational Exposure / Q000009:adverse effects; D020370:Osteoarthritis, Knee / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D059408:Pain Management; D012737:Sex Factors
keywords: Activity; Biomarkers; Injury; Knee; Occupation; Osteoarthritis