title: Review of Cutaneous Graft-vs-Host Disease.
abstract: Graft-vs-host disease (GVHD) is a multisystem disease that arises as a complication of allogeneic hematopoietic stem cell transplant. It is due to recognition of the recipient's tissues by immune cells from the donor. The skin and mucous membranes are the organs most commonly affected. GVHD is classified as acute or chronic depending on the pathophysiology and clinical presentation. Acute GVHD typically presents with the triad of rash, diarrhea, and hyperbilirubinemia, and treatment is based on systemic corticosteroid and immunosuppressant therapy. The cutaneous manifestations of chronic GVHD are divided into sclerodermiform and nonsclerodermiform, and the mucous membranes and skin appendages may also be affected. The diagnosis is mainly clinical, but skin biopsy can help in doubtful cases. Treatment can be topical, systemic, or physical, depending on the size, site, and depth of the lesions and the involvement of other organs.
authors.affiliation: Servicio de Dermatología, Hospital Universitario y Politécnico La Fe de Valencia, Valencia, España. Electronic address: roseta999@hotmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Ballester-Sánchez
authors.affiliation: Servicio de Dermatología, Hospital Universitario y Politécnico La Fe de Valencia, Valencia, España.
authors.forename: M
authors.initials: M
authors.lastname: Navarro-Mira
authors.affiliation: Servicio de Hematología y Hemoterapia, Hospital Universitario y Politécnico La Fe de Valencia, Valencia, España.
authors.forename: J
authors.initials: J
authors.lastname: Sanz-Caballer
authors.affiliation: Servicio de Dermatología, Hospital Universitario y Politécnico La Fe de Valencia, Valencia, España.
authors.forename: R
authors.initials: R
authors.lastname: Botella-Estrada
mesh_terms: D000208:Acute Disease; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000503:physiopathology*; D006801:Humans; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000503:physiopathology*
keywords: Cutaneous graft-versus-host disease; Dermatopatología; Dermopathology; Enfermedad injerto contra huésped cutánea; Hematopoietic stem cell transplant; Trasplante de progenitores hematopoyéticos