title: Kennedy Disease Misdiagnosed as Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes (POEMS) Syndrome: A Case Report.
abstract: OBJECTIVE
  The aim of this paper was to report the first case of Kennedy disease misdiagnosed as polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome.
  
  
  METHODS
  A 58-year-old Chinese man presented with limb numbness, progressive limb proximal weakness, lymph node and thyroid enlargement, edema, pigmentation in the lower limb, and obvious gynecomastia, which was initially diagnosed as POEMS syndrome and was treated with dexamethasone and small doses of cyclophosphamide without any improvement after 6 months. Finally, the patient diagnosis was confirmed as Kennedy disease (KD) by gene analysis.
  
  
  CONCLUSIONS
  This case suggests that clinicians should pay more attention to the differential diagnosis between KD and POEMS syndrome. Gene analysis was helpful in detecting this rare confusing disease in this patient.
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yuan
authors.forename: Weiping
authors.initials: W
authors.lastname: Chen
authors.forename: Huangyan
authors.initials: H
authors.lastname: Zhou
authors.forename: Zhilong
authors.initials: Z
authors.lastname: Xiao
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Weidong
authors.initials: W
authors.lastname: Wang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Yin
authors.forename: Lijun
authors.initials: L
authors.lastname: Xu
mesh_terms: D044466:Asian People; D055534:Bulbo-Spinal Atrophy, X-Linked / Q000175:diagnosis*; D002681:China; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D016878:POEMS Syndrome / Q000175:diagnosis*