title: Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix.
abstract: Disseminated intravascular coagulation (DIC) with excessive fibrinolysis (XFL) is a rare and acute life-threatening variant of DIC in patients with prostate cancer. Patients present with coagulopathy, hypofibrinogenemia, and systemic bleeding. We describe a case of DIC XFL caused by prostate cancer (PC) successfully treated with a single injection of degarelix, a gonadotropin-releasing hormone (GnRH) receptor antagonist. This led to prompt control of the patient's coagulopathy within ten days of treatment. Our case highlights features of this rare and devastating hemorrhagic complication of PC along with a fast-acting and effective therapeutic drug option.
authors.affiliation: University of Arizona College of Medicine, 1501 N. Campbell Avenue, Tucson, AZ 85724, USA.
authors.forename: Shawn Y
authors.initials: SY
authors.lastname: Ong
authors.affiliation: University of Arizona Cancer Center, 1515 N Campbell Avenue, Tucson, AZ 85724, USA.
authors.forename: Josephine
authors.initials: J
authors.lastname: Taverna
authors.affiliation: Department of Radiology, University of Arizona College of Medicine, 1501 N. Campbell Avenue, Tucson, AZ 85724, USA.
authors.forename: Clint
authors.initials: C
authors.lastname: Jokerst
authors.affiliation: Department of Medicine, University of Arizona College of Medicine, 1501 N. Campbell Avenue, RM 6336, Tucson, AZ 85724, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Enzler
authors.affiliation: Department of Medicine, University of Arizona College of Medicine, 1501 N. Campbell Avenue, RM 6336, Tucson, AZ 85724, USA.
authors.forename: Emad
authors.initials: E
authors.lastname: Hammode
authors.affiliation: Scripps Health, Department of Medicine, 10666 N Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Elisa
authors.initials: E
authors.lastname: Rogowitz
authors.affiliation: Department of Pharmacy Services, University of Arizona Medical Center, 1501 N Campbell Avenue, Tucson, AZ 85724, USA.
authors.forename: Myke R
authors.initials: MR
authors.lastname: Green
authors.affiliation: University of Arizona Cancer Center, 1515 N Campbell Avenue, Tucson, AZ 85724, USA ; Virginia G. Piper Cancer Center Clinical Trials at HonorHealth Research Institute, 10510 N 92nd Street, Suite 200, Scottsdale, AZ 85258, USA.
authors.forename: Hani M
authors.initials: HM
authors.lastname: Babiker