title: Study Design and Interim Outcomes of Guangzhou Institute of Respiratory Disease COPD Biobank.
abstract: BACKGROUND
  GIRD COPD Biobank is a multicenter observational study blood-based database with local characteristics, in order to investigate the causes, risk factors, pathogenesis, prevalence patterns and trends of COPD and promote new pathogenic insights in China.
  
  
  METHODS
  We enrolled 855 clinically COPD patients and 660 controls with normal lung function. Extensive data collection has been undertaken with questionnaires, clinical measurements, and collection and storage of blood specimens, following Standard Operating Procedures (SOP). All surveys had similar quality controls, supervisions, and training of the investigator team.
  
  
  RESULTS
  Since September 2010, a total of 1515 subjects (1116 [73.7%] males; 855 [56.4%] diagnosed with COPD) were enrolled. Analyses of the design and interim results of the GIRD COPD Biobank Study identified patients with COPD were older, lower educational level, a longer history of pack-year smoking, less in kitchen fan usage, X-ray exposure, and history of disease (P < 0.01 for all); Most of the COPD subjects belonged to moderately severe or worse, stratified according to Global Lung Function Initiative (GLI); COPD patients had relatively more co-morbidities than controls; Environmental hazard exposures might be the main contributors to the reported respiratory symptoms; Cold air, haze, and influenza acted the top three factors to induce respiratory symptoms in both COPD cases and controls.
  
  
  CONCLUSIONS
  The GIRD COPD Biobank Study has the potential to provide substantial novel insights into the genetics, biomarkers, environmental and lifestyle aspects of COPD. It is expected to provide new insights for pathogenesis and the long-term progression of COPD.
authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.|b Department of Laboratory Medicine, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: c Department of Respiratory Medicine, The First Municipal Hospital of Lufeng , Lufeng , Guangdong , China.
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authors.affiliation: d Department of Respiratory Medicine, The First Municipal Hospital of Chenzhou , Chenzhou , Hunan , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.|e The Institute for Chemical Carcinogenesis, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.|e The Institute for Chemical Carcinogenesis, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.affiliation: a State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University , Guangzhou , Guangdong , China.
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authors.lastname: Zhong
mesh_terms: D000368:Aged; D018070:Biological Specimen Banks; D015415:Biomarkers / Q000032:analysis*; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism; D012107:Research Design; D012189:Retrospective Studies; D012307:Risk Factors; D013147:Spirometry; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers
keywords: COPD; biobank; observational study; respiratory diseases/symptoms