title: Cartilage oligomeric matrix protein and hyaluronic acid are sensitive serum biomarkers for early cartilage lesions in the knee joint.
abstract: The purpose of this study was to evaluate the relationship between five previously established serum osteoarthritis biomarkers and the severity of cartilage lesions in the knee. Cartilage damage (classified according to the Outerbridge scoring system) and serum concentrations of cartilage oligomeric matrix protein (COMP), collagen type II C-telopeptide (CTX-II), matrix metalloproteinase-3 (MMP-3), collagen type III N-propeptide, (PIIINP), and hyaluronic acid (HA) were determined in 79 patients who underwent knee arthroscopy or total knee replacement. HA and COMP concentrations were significantly higher in the Outerbridge score 1 and 2 groups, respectively. These results suggest that serum COMP and HA concentrations can be used to predict early cartilage lesions in the knee.
authors.affiliation: a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi Province , People's Republic of China and.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Jiao
authors.affiliation: a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi Province , People's Republic of China and.|b Department of Orthopedics , Rhode Island Hospital, Warren Alpert Medical School of Brown University , Providence , RI , USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Wei
authors.affiliation: a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi Province , People's Republic of China and.
authors.forename: Chongwei
authors.initials: C
authors.lastname: Chen
authors.affiliation: a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi Province , People's Republic of China and.
authors.forename: Pengcui
authors.initials: P
authors.lastname: Li
authors.affiliation: a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi Province , People's Republic of China and.
authors.forename: Xiaohu
authors.initials: X
authors.lastname: Wang
authors.affiliation: a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi Province , People's Republic of China and.
authors.forename: Yongping
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi Province , People's Republic of China and.
authors.forename: Li
authors.initials: L
authors.lastname: Guo
authors.affiliation: a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi Province , People's Republic of China and.
authors.forename: Congming
authors.initials: C
authors.lastname: Zhang
authors.affiliation: a Department of Orthopedics , Shanxi Key Lab of Bone and Soft Tissue Injury Repair, The Second Hospital of Shanxi Medical University , Taiyuan, Shanxi Province , People's Republic of China and.
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Wei
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D019645:Arthroplasty, Replacement, Knee; D001182:Arthroscopy; D015415:Biomarkers / Q000097:blood*; D064236:Cartilage Oligomeric Matrix Protein / Q000097:blood*; D024043:Collagen Type II / Q000097:blood; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000097:blood; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D010446:Peptide Fragments / Q000097:blood; D011347:Procollagen / Q000097:blood; D011379:Prognosis
chemical_list: D015415:Biomarkers; D064236:Cartilage Oligomeric Matrix Protein; D024043:Collagen Type II; D010446:Peptide Fragments; D011347:Procollagen; C543437:collagen II C-telopeptide; C041876:procollagen Type III-N-terminal peptide; D006820:Hyaluronic Acid; D019278:Matrix Metalloproteinase 3
keywords: Biomarker; early cartilage lesion; knee; osteoarthritis