title: Effect of Repeated Recruitment Manoeuvres on Patients with Severe Acute Respiratory Distress Syndrome.
abstract: OBJECTIVE
  The study aimed to evaluate the influence of repeated recruitment manoeuvres (RRMs) on lung injury in patients with acute respiratory distress syndrome (ARDS).
  
  
  METHODS
  Forty-one ventilated patients with severe ARDS were selected for this study. Recruitment manoeuvres (RMs) were conducted with continuous positive airway pressure (CPAP; 30 cm H2O for 40 seconds). Recruitment manoeuvres were repeated every two hours for all three groups. Changes in haemodynamics, pulmonary compliance, gas exchange and extravascular lung water index (EVLWI) were monitored before RM (pre-RM), 10 minutes after each RM, and four hours after RM3 (4 hours post-RRM). Pulmonary inflammatory factors (tumour necrosis factor-alpha [TNF-α] and interleukin [IL]-6 and -10) were also analysed.
  
  
  RESULTS
  Compared with those in pre-RM, pulmonary compliance, oxygenation index (ratio of partial pressure of arterial oxygen to fraction of inspired oxygen [PaO2/FiO2]) and EVLWI remarkably improved in RM1, RM2, RM3 and 4 hours post-RRM (p < 0.05). The PaO2/FiO2 ratio increased significantly in RM1 and RM3 (p < 0.05). Extravascular lung water index decreased significantly in RM1 compared with that in RM3 and 4 hours post-RRM (p < 0.05). There was no significant difference in cytokines.
  
  
  CONCLUSIONS
  Repeated recruitment manoeuvres during lung-protected ventilation can improve pulmonary compliance and oxygenation and significantly decrease extravascular lung water in ARDS patients. Lung injury was not worsened by RRMs in patients with severe ARDS.
authors.affiliation: Department of Critical Care Medicine, XuZhou Central Hospital, The Affiliated XuZhou Hospital of Medical College of Southeast University, Xuzhou Clinical Medical College of Nanjing University of Chinese Medicine, 199 Jiefang Road, Xuzhou 221009, Jiangsu Province, China. mqjqcn@163.com.
authors.forename: M-Q
authors.initials: MQ
authors.lastname: Li
authors.affiliation: Department of Critical Care Medicine, XuZhou Central Hospital, The Affiliated XuZhou Hospital of Medical College of Southeast University, Xuzhou Clinical Medical College of Nanjing University of Chinese Medicine, Xuzhou 221009, Jiangsu Province, China.
authors.forename: G-J
authors.initials: GJ
authors.lastname: Han
authors.affiliation: Department of Critical Care Medicine, XuZhou Central Hospital, The Affiliated XuZhou Hospital of Medical College of Southeast University, Xuzhou Clinical Medical College of Nanjing University of Chinese Medicine, Xuzhou 221009, Jiangsu Province, China.
authors.forename: J-Q
authors.initials: JQ
authors.lastname: Li
authors.affiliation: Department of Critical Care Medicine, XuZhou Central Hospital, The Affiliated XuZhou Hospital of Medical College of Southeast University, Xuzhou Clinical Medical College of Nanjing University of Chinese Medicine, Xuzhou 221009, Jiangsu Province, China.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Xu
authors.affiliation: Department of Critical Care Medicine, XuZhou Central Hospital, The Affiliated XuZhou Hospital of Medical College of Southeast University, Xuzhou Clinical Medical College of Nanjing University of Chinese Medicine, Xuzhou 221009, Jiangsu Province, China.
authors.forename: Z-X
authors.initials: ZX
authors.lastname: Shi
authors.affiliation: Department of Critical Care Medicine, XuZhou Central Hospital, The Affiliated XuZhou Hospital of Medical College of Southeast University, Xuzhou Clinical Medical College of Nanjing University of Chinese Medicine, Xuzhou 221009, Jiangsu Province, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Critical Care Medicine, XuZhou Central Hospital, The Affiliated XuZhou Hospital of Medical College of Southeast University, Xuzhou Clinical Medical College of Nanjing University of Chinese Medicine, Xuzhou 221009, Jiangsu Province, China.
authors.forename: F
authors.initials: F
authors.lastname: Lu
authors.affiliation: Department of Critical Care Medicine, XuZhou Central Hospital, The Affiliated XuZhou Hospital of Medical College of Southeast University, Xuzhou Clinical Medical College of Nanjing University of Chinese Medicine, Xuzhou 221009, Jiangsu Province, China.
authors.forename: X-M
authors.initials: XM
authors.lastname: Wang
authors.affiliation: Department of Critical Care Medicine, XuZhou Central Hospital, The Affiliated XuZhou Hospital of Medical College of Southeast University, Xuzhou Clinical Medical College of Nanjing University of Chinese Medicine, Xuzhou 221009, Jiangsu Province, China.
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Xu
authors.affiliation: Department of Critical Care Medicine, XuZhou Central Hospital, The Affiliated XuZhou Hospital of Medical College of Southeast University, Xuzhou Clinical Medical College of Nanjing University of Chinese Medicine, Xuzhou 221009, Jiangsu Province, China.
authors.forename: X
authors.initials: X
authors.lastname: Mo