title: SFINX: Straightforward Filtering Index for Affinity Purification-Mass Spectrometry Data Analysis.
abstract: Affinity purification-mass spectrometry is one of the most common techniques for the analysis of protein-protein interactions, but inferring bona fide interactions from the resulting data sets remains notoriously difficult. We introduce SFINX, a Straightforward Filtering INdeX that identifies true-positive protein interactions in a fast, user-friendly, and highly accurate way. SFINX outperforms alternative techniques on two benchmark data sets and is available via the Web interface at http://sfinx.ugent.be/.
authors.affiliation: VIB Medical Biotechnology Center , A. Baertsoenkaai 3, B-9000 Ghent, Belgium.|Department of Biochemistry, Ghent University , B-9000 Ghent, Belgium.
authors.forename: Kevin
authors.initials: K
authors.lastname: Titeca
authors.affiliation: Advanced Database Research and Modelling (ADReM), Department of Mathematics and Computer Science, University of Antwerp , B-2020 Antwerp, Belgium.|Biomedical Informatics Research Center Antwerp (biomina), University of Antwerp/Antwerp University Hospital , B-2650 Edegem, Belgium.
authors.forename: Pieter
authors.initials: P
authors.lastname: Meysman
authors.affiliation: VIB Medical Biotechnology Center , A. Baertsoenkaai 3, B-9000 Ghent, Belgium.|Department of Biochemistry, Ghent University , B-9000 Ghent, Belgium.
authors.forename: Kris
authors.initials: K
authors.lastname: Gevaert
authors.affiliation: VIB Medical Biotechnology Center , A. Baertsoenkaai 3, B-9000 Ghent, Belgium.|Department of Biochemistry, Ghent University , B-9000 Ghent, Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: Tavernier
authors.affiliation: Advanced Database Research and Modelling (ADReM), Department of Mathematics and Computer Science, University of Antwerp , B-2020 Antwerp, Belgium.|Biomedical Informatics Research Center Antwerp (biomina), University of Antwerp/Antwerp University Hospital , B-2650 Edegem, Belgium.
authors.forename: Kris
authors.initials: K
authors.lastname: Laukens
authors.affiliation: VIB Medical Biotechnology Center , A. Baertsoenkaai 3, B-9000 Ghent, Belgium.|Department of Biochemistry, Ghent University , B-9000 Ghent, Belgium.|Bioinformatics Institute Ghent, Ghent University , B-9000 Ghent, Belgium.
authors.forename: Lennart
authors.initials: L
authors.lastname: Martens
authors.affiliation: VIB Medical Biotechnology Center , A. Baertsoenkaai 3, B-9000 Ghent, Belgium.|Department of Biochemistry, Ghent University , B-9000 Ghent, Belgium.
authors.forename: Sven
authors.initials: S
authors.lastname: Eyckerman
mesh_terms: D000465:Algorithms; D002846:Chromatography, Affinity; D006801:Humans; D013058:Mass Spectrometry; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D020543:Proteome / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D020543:Proteome
keywords: affinity purification−mass spectrometry; interaction detection; interaction filtering; interactomics; protein−protein interactions