title: Infracentimetric HER-2 positive breast tumours-review of the literature.
abstract: Breast cancer is the most common malignant neoplasm in the world among women. As a result of the dissemination of population screening programmes, about half of non-metastatic breast cancers are now diagnosed at stage I. 10-15% of T1abN0 tumours over-express human epidermal growth factor (HER-2). These tumours have a globally excellent prognosis, however, treatment with chemotherapy and/or targeted therapy may further improve outcomes in selected cases. In this article, we will review studies with information on prognosis and benefit of adjuvant therapy for T1abN0 HER-2+ breast cancer.
authors.affiliation: Instituto do Câncer do Estado de São Paulo - ICESP - Faculdade de Medicina da Universidade de São Paulo, Av. Doutor Arnaldo, 251 - Cerqueira César, São Paulo - SP 01246-000, Brazil.
authors.forename: Danilo
authors.initials: D
authors.lastname: da Fonseca Reis Silva
authors.affiliation: Breast Unit, Champalimaud Clinical Centre, Av. de Brasília, s/n, Lisbon 1400-038, Portugal.
authors.forename: Joana M
authors.initials: JM
authors.lastname: Ribeiro
keywords: HER-2 positive breast cancer; breast cancer; infracentimetric