title: Small Cell Lung Cancer Expressing Glutamate Decarboxylase with Latent Autoimmune Diabetes in Adults.
abstract: Small cell lung cancer (SCLC) causes paraneoplastic syndromes, such as diabetes mellitus, by eliciting the expression of various antibodies including anti-glutamate decarboxylase (GAD) antibody. A 62-year-old woman presented to our hospital with a 1-week history of progressive dyspnea and difficulty in walking. Computed tomography showed a tumor obstructing the left bronchus and obstructive lung abscesses with pleural effusions. A biopsy during bronchoscopy revealed SCLC, and the clinical stage was ultimately determined to be IIIB. SCLC was complicated by diabetes mellitus with high titers of serum anti-GAD antibody. An immunohistochemical analysis showed GAD expression in the cancer cells, which is a novel finding.
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Tokyo Medical Center, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Asakura
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yoshida
authors.forename: Arafumi
authors.initials: A
authors.lastname: Maeshima
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Rie
authors.initials: R
authors.lastname: Jo
authors.forename: Kyoko
authors.initials: K
authors.lastname: Iwase
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Oyamada
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D005260:Female; D018149:Glucose Intolerance; D005968:Glutamate Decarboxylase / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D055752:Small Cell Lung Carcinoma / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D005968:Glutamate Decarboxylase