title: A new pyrone derivative from an endophytic Aspergillus tubingensis of Lycium ruthenicum.
abstract: A new pyrone named 6-isovaleryl-4-methoxy-pyran-2-one (1), along with three known pyrone compounds, rubrofusarin B (2), asperpyrones A (3) and campyrone A (4), was isolated from fermentation of Aspergillus tubingensis in Lycium ruthenicum. Their structures were confirmed by spectroscopic techniques, such as IR, NMR and HRESI-MS. Compound 2 indicated strong inhibitory activity against Escherichia coli, with MIC value of 1.95 μg/mL.
authors.affiliation: a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education , Shaanxi University of Science & Technology , Xi'an , P.R. China.
authors.forename: Yang-Min
authors.initials: YM
authors.lastname: Ma
authors.affiliation: a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education , Shaanxi University of Science & Technology , Xi'an , P.R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.affiliation: a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education , Shaanxi University of Science & Technology , Xi'an , P.R. China.
authors.forename: Cong-Cong
authors.initials: CC
authors.lastname: Ma
mesh_terms: D001230:Aspergillus / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects; D005285:Fermentation; D032305:Lycium / Q000382:microbiology*; D009682:Magnetic Resonance Spectroscopy; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014631:Valerates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C000617271:6-isovaleryl-4-methoxy-pyran-2-one; D011753:Pyrones; D014631:Valerates; C015497:rubrofusarin
keywords: 6-isovaleryl-4-methoxy-pyran-2-one; Aspergillus tubingensis; Lycium ruthenicum; Pyrone; endophytic fungi