title: Association between ErbB3 genetic polymorphisms and coronary artery disease in the Han and Uyghur populations of China.
abstract: BACKGROUND
  ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. Recent research has shown that amplification of this gene is related to prostate, bladder and breast cancers, as well as low-density lipoprotein cholesterol (LDL-C) metabolism. LDL-C plays a considerable role in the development of cardiovascular disease. Thus, the present study assessed the association between human ErbB3 gene polymorphisms and coronary artery disease (CAD) in Han and Uygur populationsin China.
  
  
  METHODS
  We performed two independent case-control studies with a Han population (339 CAD patients and 395 control subjects) and a Uygur population (306 CAD patients and 325 control subjects). All of the CAD patients and controls were genotyped for the same three single nucleotide polymorphisms (rs877636, rs705708, and rs10783779) in the ErbB3 gene by real-time PCR.
  
  
  RESULTS
  In the Han population, rs877636 polymorphisms were associated with CAD on the basis of the genotypes, dominant model, additive model, and allele frequency (for genotypes: P = 0.008; for dominant model: P = 0.003; for additive model: P = 0.004; for allele: P = 0.008), and these significant difference was retained (all P < 0.05) after adjusting for the major confounding factors.
  
  
  CONCLUSIONS
  The CT genotype and C allele of rs877636 in the ErbB3 gene could be a genetic marker of CAD risk for the Han population in China.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, People's Republic of China.
authors.forename: Buamina
authors.initials: B
authors.lastname: Maitusong
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, People's Republic of China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, People's Republic of China ; Xinjiang Key Laboratory of Cardiovascular Disease Research Urumqi 830054, People's Republic of China.
authors.forename: Yi-Tong
authors.initials: YT
authors.lastname: Ma
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, People's Republic of China ; Xinjiang Key Laboratory of Cardiovascular Disease Research Urumqi 830054, People's Republic of China.
authors.forename: Zhen-Yan
authors.initials: ZY
authors.lastname: Fu
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, People's Republic of China ; Xinjiang Key Laboratory of Cardiovascular Disease Research Urumqi 830054, People's Republic of China.
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Yang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, People's Republic of China ; Xinjiang Key Laboratory of Cardiovascular Disease Research Urumqi 830054, People's Republic of China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: Xinjiang Key Laboratory of Cardiovascular Disease Research Urumqi 830054, People's Republic of China.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.affiliation: Xinjiang Key Laboratory of Cardiovascular Disease Research Urumqi 830054, People's Republic of China.
authors.forename: Bang-Dang
authors.initials: BD
authors.lastname: Chen
authors.affiliation: Xinjiang Key Laboratory of Cardiovascular Disease Research Urumqi 830054, People's Republic of China.
authors.forename: Min-Tao
authors.initials: MT
authors.lastname: Gai
keywords: ErbB3; SREBF2; case-control study; coronary artery disease; single nucleotide polymorphism