title: Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson's Disease.
abstract: Gene therapy methods are increasingly used to model Parkinson's disease (PD) in animals in an effort to test experimental therapeutics within a more relevant context to disease pathophysiology and neuropathology. We have detailed several criteria that are critical or advantageous to accurately modeling PD in a murine model or in a nonhuman primate. Using these criteria, we then evaluate approaches made to model PD using viral vectors to date, including both adeno-associated viruses and lentiviruses. Lastly, we comment on the consideration of aging as a critical factor for modeling PD.
authors.affiliation: Department of Translational Science & Molecular Medicine, Michigan State University, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503-2532, USA.|MD/PhD Program, Michigan State University, Grand Rapids, MI, USA.|Neuroscience Graduate Program, Michigan State University, Grand Rapids, MI, USA.
authors.forename: D Luke
authors.initials: DL
authors.lastname: Fischer
authors.affiliation: Department of Translational Science & Molecular Medicine, Michigan State University, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503-2532, USA.|Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH, USA.
authors.forename: Sara E
authors.initials: SE
authors.lastname: Gombash
authors.affiliation: Department of Translational Science & Molecular Medicine, Michigan State University, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503-2532, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Kemp
authors.affiliation: Translational Science and Molecular Medicine, Michigan State University, College of Human Science, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503-2532, USA.
authors.forename: Fredric P
authors.initials: FP
authors.lastname: Manfredsson
authors.affiliation: Department of Translational Science & Molecular Medicine, Michigan State University, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503-2532, USA.|Neuroscience Graduate Program, Michigan State University, Grand Rapids, MI, USA.
authors.forename: Nicole K
authors.initials: NK
authors.lastname: Polinski
authors.affiliation: Department of Translational Science & Molecular Medicine, Michigan State University, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503-2532, USA.|Neuroscience Graduate Program, Michigan State University, Grand Rapids, MI, USA.
authors.forename: Megan F
authors.initials: MF
authors.lastname: Duffy
authors.affiliation: Department of Translational Science & Molecular Medicine, Michigan State University, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503-2532, USA. caryl.sortwell@hc.msu.edu.
authors.forename: Caryl E
authors.initials: CE
authors.lastname: Sortwell
mesh_terms: D000818:Animals; D000229:Dependovirus / Q000235:genetics*; D004195:Disease Models, Animal; D015316:Genetic Therapy; D005822:Genetic Vectors; D016086:Lentivirus / Q000235:genetics*; D051379:Mice; D010300:Parkinson Disease / Q000473:pathology* / Q000628:therapy
keywords: Adeno-associated virus; Dopamine; Lentivirus; Leucine-rich repeat kinase 2; Lewy body; PTEN-induced putative kinase 1; Parkin; Parkinson’s disease; Striatum; Substantia nigra; Tyrosine hydroxylase; α-synuclein