title: Analyzing the Correlation between the Level of Serum Markers and Ischemic Cerebral Vascular Disease by Multiple Parameters.
abstract: OBJECTIVE
  To explore the serum markers associated with ischemic cerebral vascular disease (ICVD) and discuss their diagnostic value.
  
  
  METHODS
  Two hundred and eighty-eight patients with ICVD and one hundred and eighty healthy persons were enrolled as the case group and the control group, respectively. This paper then carried out the univariate and multivariate logistic regression analyses of their respective levels of serum markers, made combined analysis of related factors, and detected the diagnostic value.
  
  
  RESULTS
  Meta-analysis results showed that for ICVD patients the levels of CRP, S-100, TNF-α, HCY, NSE, and IL-6 were higher than those of the healthy persons, while the level of HDL was obviously lower than that of the healthy persons. The multivariate regression analysis indicated that the association between the level of HDL and TNF-α and the occurrence of ICVD was statistically significant (P < 0.05). The area under the curves (AUC) of receiver operating characteristic (ROC) curve of HDL and TNF-α was 0.916, with sensitivity of 90.91% and specificity of 76.47%.
  
  
  CONCLUSIONS
  HDL has negative correlation with the occurrence of ICVD, while TNF-α was positively correlated with it. The combination test of HDL and TNF-α could raise the accuracy of ICVD diagnosis.
authors.affiliation: Department of Neurology, The Ninth People's Hospital of Zhengzhou, Zhengzhou 450000, China.
authors.forename: Laibin
authors.initials: L
authors.lastname: Dong
authors.affiliation: Department of Neurology, The Ninth People's Hospital of Zhengzhou, Zhengzhou 450000, China.
authors.forename: Rongzhi
authors.initials: R
authors.lastname: Hou
authors.affiliation: Department of Neurology, The Ninth People's Hospital of Zhengzhou, Zhengzhou 450000, China.
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Ultrasound Diagnosis, Hospital of Henan Military Region, Zhengzhou 450000, China.
authors.forename: Jiaying
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Department of Neurology, The Ninth People's Hospital of Zhengzhou, Zhengzhou 450000, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Neurology, The Ninth People's Hospital of Zhengzhou, Zhengzhou 450000, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Department of Neurology, The Ninth People's Hospital of Zhengzhou, Zhengzhou 450000, China.
authors.forename: Hehua
authors.initials: H
authors.lastname: Zhao
mesh_terms: D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood*; D002545:Brain Ischemia / Q000097:blood* / Q000175:diagnosis*; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D019295:Computational Biology; D006710:Homocysteine / Q000097:blood; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D010751:Phosphopyruvate Hydratase / Q000097:blood; D012372:ROC Curve; D009418:S100 Proteins / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D008075:Lipoproteins, HDL; D009418:S100 Proteins; D014409:Tumor Necrosis Factor-alpha; D006710:Homocysteine; D002097:C-Reactive Protein; D010751:Phosphopyruvate Hydratase