title: Comparison of the Clinical Characteristics and Outcome of Benign and Malignant Eyelid Tumors: An Analysis of 4521 Eyelid Tumors in a Tertiary Medical Center.
abstract: We retrospectively reviewed the clinical features and outcome of benign and malignant eyelid tumors from 1995 to 2015 in a tertiary medical center. Among 4,521 histologically confirmed eyelid tumors, 4,294 (95.0%) were benign tumors and 227 (5.0%) were malignant tumors. The mean age at diagnosis was significantly higher in patients with malignant lid tumors than those with benign lid tumors (72.5 and 55.4 years, resp., p < 0.001). The most common benign eyelid tumors were intradermal nevus (21.1%), followed by seborrheic keratosis (12.6%) and xanthelasma (11.2%). The most common malignant eyelid tumors were basal cell carcinomas (57.8%), followed by sebaceous gland carcinomas (21.1%) and squamous cell carcinomas (10.1%). There was a relative male predominance (63.4% and 49.2%, resp., p < 0.001) and higher recurrence rate (11.9% and 4.4%, resp., p < 0.001) in malignant lid tumors as compared with those of benign lid tumors. Twenty-two patients (9.7%) received orbital exenteration/enucleation. Eight patients (3.5%) with malignant lid tumors died of disease. Patients with eyelid melanoma were associated with a high mortality rate (25.0%). It is important to differentiate between benign and malignant eyelid tumors, because they may cause cosmetic disfigurement and severe morbidity, especially in those with malignant eyelid tumors.
authors.affiliation: Department of Ophthalmology, Taipei Veterans General Hospital, No. 201, Sec.2, Shih-Pai Road, Taipei 112, Taiwan ; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Yu-Yun
authors.initials: YY
authors.lastname: Huang
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei, Taiwan ; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taiwan.
authors.forename: Wen-Yih
authors.initials: WY
authors.lastname: Liang
authors.affiliation: Department of Ophthalmology, Taipei Veterans General Hospital, No. 201, Sec.2, Shih-Pai Road, Taipei 112, Taiwan ; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Chieh-Chih
authors.initials: CC
authors.lastname: Tsai
authors.affiliation: Department of Ophthalmology, Taipei Veterans General Hospital, No. 201, Sec.2, Shih-Pai Road, Taipei 112, Taiwan ; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Shu-Ching
authors.initials: SC
authors.lastname: Kao
authors.affiliation: Department of Ophthalmology, Taipei Veterans General Hospital, No. 201, Sec.2, Shih-Pai Road, Taipei 112, Taiwan ; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Wei-Kuang
authors.initials: WK
authors.lastname: Yu
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei, Taiwan ; Department of Ophthalmology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei 112, Taiwan.
authors.forename: Hui-Chuan
authors.initials: HC
authors.lastname: Kau
authors.affiliation: Department of Ophthalmology, Taipei Veterans General Hospital, No. 201, Sec.2, Shih-Pai Road, Taipei 112, Taiwan ; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Catherine Jui-Ling
authors.initials: CJ
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005142:Eyelid Neoplasms / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000517:prevention & control; D015995:Prevalence; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy; D015996:Survival Rate; D013624:Taiwan / Q000453:epidemiology; D062606:Tertiary Care Centers / Q000706:statistics & numerical data*; D055815:Young Adult