title: Establishing a Fecal Microbiota Transplant Service for the Treatment of Clostridium difficile Infection.
abstract: Recurrent or refractory Clostridium difficile infection (CDI) has become an increasing problem in the past decade. Fecal microbiota transplant (FMT) is a highly efficacious treatment for recurrent CDI; however, a number of technical, logistical, and regulatory issues have hampered the development of an FMT capability at many hospitals. The development of a frozen stool bank of screened donor stool is an important step in the standardization of the procedure. This gives clinicians rapid access to thoroughly screened donor stool when needed, without the ethical and logistical problems associated with patient-selected donors. We describe the practicalities of establishing such a service using a stool bank of prescreened donor stool including detail regarding donor recruitment and screening, stool preparation, and delivery of the FMT.
authors.affiliation: Department of Gastroenterology, The Queen Elizabeth Hospital, Woodville Department of Gastroenterology & School of Medicine, University of Adelaide at Royal Adelaide Hospital.
authors.forename: Samuel P
authors.initials: SP
authors.lastname: Costello
authors.affiliation: Department of Infectious Diseases and Microbiology, Flinders Medical Centre, Bedford Park.
authors.forename: Emily C
authors.initials: EC
authors.lastname: Tucker
authors.affiliation: Department of Infectious Diseases, Royal Adelaide Hospital, South Australia.
authors.forename: Justin
authors.initials: J
authors.lastname: La Brooy
authors.affiliation: Department of Gastroenterology & School of Medicine, University of Adelaide at Royal Adelaide Hospital.
authors.forename: Mark N
authors.initials: MN
authors.lastname: Schoeman
authors.affiliation: Department of Gastroenterology & School of Medicine, University of Adelaide at Royal Adelaide Hospital.
authors.forename: Jane M
authors.initials: JM
authors.lastname: Andrews
mesh_terms: D000328:Adult; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000382:microbiology / Q000628:therapy*; D000069467:Fecal Microbiota Transplantation / Q000379:methods / Q000592:standards; D005243:Feces / Q000382:microbiology / Q000469:parasitology / Q000821:virology; D006801:Humans; D008875:Middle Aged; D014015:Tissue Banks; D014019:Tissue Donors; D055815:Young Adult
keywords: Clostridium difficile; donor; fecal microbiota transplant; screening; stool bank