title: Advancing Cardiovascular, Neurovascular, and Renal Magnetic Resonance Imaging in Small Rodents Using Cryogenic Radiofrequency Coil Technology.
abstract: Research in pathologies of the brain, heart and kidney have gained immensely from the plethora of studies that have helped shape new methods in magnetic resonance (MR) for characterizing preclinical disease models. Methodical probing into preclinical animal models by MR is invaluable since it allows a careful interpretation and extrapolation of data derived from these models to human disease. In this review we will focus on the applications of cryogenic radiofrequency (RF) coils in small animal MR as a means of boosting image quality (e.g., by supporting MR microscopy) and making data acquisition more efficient (e.g., by reducing measuring time); both being important constituents for thorough investigational studies on animal models of disease. This review attempts to make the (bio)medical imaging, molecular medicine, and pharmaceutical communities aware of this productive ferment and its outstanding significance for anatomical and functional MR in small rodents. The goal is to inspire a more intense interdisciplinary collaboration across the fields to further advance and progress non-invasive MR methods that ultimately support thorough (patho)physiological characterization of animal disease models. In this review, current and potential future applications for the RF coil technology in cardiovascular, neurovascular, and renal disease will be discussed.
authors.affiliation: Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association Berlin, Germany ; German Centre for Cardiovascular Research Berlin, Germany.
authors.forename: Thoralf
authors.initials: T
authors.lastname: Niendorf
authors.affiliation: Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association Berlin, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Pohlmann
authors.affiliation: Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association Berlin, Germany.
authors.forename: Henning M
authors.initials: HM
authors.lastname: Reimann
authors.affiliation: MRI.TOOLS GmbH Berlin, Germany.
authors.forename: Helmar
authors.initials: H
authors.lastname: Waiczies
authors.affiliation: Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association Berlin, Germany.
authors.forename: Eva
authors.initials: E
authors.lastname: Peper
authors.affiliation: Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association Berlin, Germany.
authors.forename: Till
authors.initials: T
authors.lastname: Huelnhagen
authors.affiliation: Center for Cardiovascular Research, Institute of Physiology, Charité-Universitätsmedizin Berlin Berlin, Germany.
authors.forename: Erdmann
authors.initials: E
authors.lastname: Seeliger
authors.affiliation: Clinic for Nephrology and Intensive Care Medicine, Charité Medical Faculty and Experimental and Clinical Research Center Berlin, Germany.
authors.forename: Adrian
authors.initials: A
authors.lastname: Schreiber
authors.affiliation: Clinic for Nephrology and Intensive Care Medicine, Charité Medical Faculty and Experimental and Clinical Research Center Berlin, Germany.
authors.forename: Ralph
authors.initials: R
authors.lastname: Kettritz
authors.affiliation: Bruker BioSpin MRI GmbH Ettlingen, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Strobel
authors.affiliation: Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association Berlin, Germany.
authors.forename: Min-Chi
authors.initials: MC
authors.lastname: Ku
authors.affiliation: Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association Berlin, Germany.
authors.forename: Sonia
authors.initials: S
authors.lastname: Waiczies
keywords: MR technology; MRI; cardiovascular imaging; cryogenic; magnetic resonance; neurovascular imaging; renal imaging; radio frequency coils