title: Iron, inflammation and invasion of cancer cells.
abstract: Chronic inflammation is associated with the metastasis of tumor cells evolving from a benign tumor to disseminating cancer. Such a metastatic progression is fostered by the angiogenesis propelled by various mediators interacting at the site of tumor growth. Angiogenesis causes two major changes that are assisted by altered glycosylation and neo-antigen presentation by the cancer cells. The angiogenesis-promoted pathological changes include enhanced inflammation and degradation of tissue matrices releasing tumor cells from the site of its origin. The degraded tumor cells release the neo-antigens resulting from altered glycosylation. Presentation of neo-antigens to T cells escalates metastasis and inflammation. Inflammasome activation and inflammation in several infections are regulated by iron. Based on the discrete reports, we propose a link between iron, inflammation, angiogenesis and tumor growth. Knowing the link better may help us formulate a novel strategy for cancer immunotherapy.
authors.affiliation: Research Department, Prof. Dr. I. Chiricuta Institute of Oncology, Cluj-Napoca, Romania ; Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Eva
authors.initials: E
authors.lastname: Fischer-Fodor
authors.affiliation: Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.
authors.forename: Natalia
authors.initials: N
authors.lastname: Miklasova
authors.affiliation: Research Department, Prof. Dr. I. Chiricuta Institute of Oncology, Cluj-Napoca, Romania ; Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Ioana
authors.initials: I
authors.lastname: Berindan-Neagoe
authors.affiliation: Department of Pathogenesis and Cellular Response, National Centre for Cell Science, Ganeshkhind, Pune, India.
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Saha
keywords: cancer; hepcidin; iron metabolism; targeted therapy