title: The Ser326Cys polymorphism of hOGG1 is associated with intrahepatic cholangiocarcinoma susceptibility in a Chinese population.
abstract: OBJECTIVE
  Intrahepatic cholangiocarcinoma is a rare disease whose etiology is far from clear, the Ser326Cys polymorphism in human 8-hydroxyguanine glycosylase (hOGG1) has been shown associated with various cancers, however, the association of Ser326Cys (rsl052133) polymorphism and intrahepatic cholangiocarcinoma susceptibility has not been clarified. The purpose of this study is to investigate whether this polymorphism is related to the genetic susceptibility of intrahepatic cholangiocarcinoma.
  
  
  METHODS
  A total 150 patients and 150 normal people were included in this study, the Ser326Cys polymorphisms in each group were genotyped using PCR-RFLP method.
  
  
  RESULTS
  We found that individuals carrying Cys/Cys genotype were exposed to higher riskof intrahepatic cholangiocarcinoma (OR=2.924, 95% CI=1.475-5.780) compared with the individuals with wild type genotype Ser/Ser. Further analysis revealed that male individuals carrying Cys/Cys genotype also had increased risk (OR=2.762, 95% CI=1.233-6.173), whereas no significant difference was observed in female group.
  
  
  CONCLUSIONS
  Therefore, our data indicates that the Ser326Cys (rs1052133) polymorphism is associated with intrahepatic cholangiocarcinoma susceptibility, and it shows preference in male population.
authors.affiliation: Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health Nanjing 210029, China ; Department of Hepatopancreatobiliary Surgery, Subei People's Hospital Yangzhou 225000, China.
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Ding
authors.affiliation: Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health Nanjing 210029, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.affiliation: Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health Nanjing 210029, China.
authors.forename: Zhengshan
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health Nanjing 210029, China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Yao
authors.affiliation: Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health Nanjing 210029, China.
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Li
authors.affiliation: Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health Nanjing 210029, China.
authors.forename: Chengyu
authors.initials: C
authors.lastname: Jiao
authors.affiliation: Department of Hepatopancreatobiliary Surgery, Subei People's Hospital Yangzhou 225000, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Qian
authors.affiliation: Department of Hepatopancreatobiliary Surgery, Subei People's Hospital Yangzhou 225000, China.
authors.forename: Dousheng
authors.initials: D
authors.lastname: Bai
authors.affiliation: Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health Nanjing 210029, China.
authors.forename: Xiangcheng
authors.initials: X
authors.lastname: Li
keywords: hOGG1; intrahepatic cholangiocarcinoma; polymorphism