title: Infiltration of trace metal ions in the oral mucosa of a rat analyzed using SRXRF, XAFS, and ICP-MS.
abstract: Although the accumulation and distribution of metals from metallic orthodontic appliances in the oral mucosa have been studied extensively, they remain unclear because their concentration is quite low. In this study, metal specimens (Ni, Ni-Ti, and Co-Cr) were sutured in the unilateral oral mucosa of rats, and the distribution of the eluted elements in the mucosal tissue was estimated using inductively coupled plasma mass spectrometry (ICP-MS) and synchrotron radiation X-ray fluorescence analysis (SR-XRF). While the infiltrations of Ni, Co, and Cr into the oral mucosal connective tissue were observed with SR-XRF, significant increases were only found in Ni from the pure Ni group and Cr from the Co-Cr group. Furthermore, Ni and Co were estimated as hydrated ions while Cr was estimated in oxide form through X-ray absorption fine structure (XAFS) analysis.
authors.affiliation: Department of Orthodontic Science, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU).
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Imamura
authors.forename: Zuisei
authors.initials: Z
authors.lastname: Kanno
authors.forename: Haruki
authors.initials: H
authors.lastname: Imai
authors.forename: Tomoko
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Takahiro
authors.initials: T
authors.lastname: Wada
authors.forename: Midori
authors.initials: M
authors.lastname: Yoshida
authors.forename: Minoru
authors.initials: M
authors.lastname: Sakama
authors.forename: Takashi
authors.initials: T
authors.lastname: Ono
authors.forename: Eiichi
authors.initials: E
authors.lastname: Honda
authors.forename: Motohiro
authors.initials: M
authors.lastname: Uo
mesh_terms: D000818:Animals; D002858:Chromium Alloys / Q000737:chemistry; D005260:Female; D008856:Microscopy, Fluorescence; D009061:Mouth Mucosa / Q000378:metabolism*; D009532:Nickel / Q000737:chemistry; D009967:Orthodontic Appliances; D051381:Rats; D017208:Rats, Wistar; D013052:Spectrometry, X-Ray Emission; D013054:Spectrophotometry, Atomic; D014025:Titanium / Q000737:chemistry; D014131:Trace Elements / Q000737:chemistry; D056928:X-Ray Absorption Spectroscopy
chemical_list: D002858:Chromium Alloys; D014131:Trace Elements; C040654:titanium nickelide; D009532:Nickel; D014025:Titanium