title: Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi.
abstract: Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).
authors.affiliation: Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China. wanfeier@live.cn.
authors.forename: Wan-Fei
authors.initials: WF
authors.lastname: Li
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, China. juan_wang2012@163.com.|School of Public Health, Jilin University, Changchun 130021, China. juan_wang2012@163.com.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China. zjj523@126.com.
authors.forename: Jing-Jie
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, China. kobe24song@126.com.
authors.forename: Xun
authors.initials: X
authors.lastname: Song
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, China. faiku2010@hkbu.edu.hk.
authors.forename: Chuen-Fai
authors.initials: CF
authors.lastname: Ku
authors.affiliation: Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China. zoujuan-729@163.com.
authors.forename: Juan
authors.initials: J
authors.lastname: Zou
authors.affiliation: Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China. lijixinmylove@yeah.net.
authors.forename: Ji-Xin
authors.initials: JX
authors.lastname: Li
authors.affiliation: Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. lijun@uic.edu.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Rong
authors.affiliation: Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China. ltpan@sina.cn.
authors.forename: Lu-Tai
authors.initials: LT
authors.lastname: Pan
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, China. zhanghj@hkbu.edu.hk.
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Zhang
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000506:poisoning; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D045786:Diterpenes, Kaurane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D032495:Pteris / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D045786:Diterpenes, Kaurane; D010936:Plant Extracts
keywords: Pteris henryi; anti-HIV activity; bioactivity evaluation; ent-kaurane diterpene; henrin A