title: Pazopanib monotherapy in a patient with a malignant granular cell tumor originating from the right orbit: A case report.
abstract: Granular cell tumors are uncommon, usually benign tumors of Schwann cell origin. The malignant variant is extremely rare, representing <2% of all granular cell tumors. Therefore, standard systemic chemotherapy for this disease does not exist. The present study reports the case of a 40-year-old female with a malignant granular cell tumor that originally arose in the right orbit and subsequently relapsed. The patient was started on pazopanib monotherapy following treatment with two investigational drugs, a smoothened inhibitor and then a phosphatidylinositol 3-kinase inhibitor, as part of a clinical trial. Although additional radiotherapy for local control was necessary, the lung metastases remained stable during the pazopanib monotherapy, which lasted for 7 months, following which a clinically stable disease state was determined. This case suggests that pazopanib can be a treatment option for the stabilization of disease progression in metastatic malignant granular cell tumor.
authors.affiliation: Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan.
authors.forename: Sachi
authors.initials: S
authors.lastname: Morita
authors.affiliation: Department of Otorhinolaryngology, Nagoya Graduate School of Medicine, Nagoya, Aichi 466-0027, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Hiramatsu
authors.affiliation: Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan.
authors.forename: Mihoko
authors.initials: M
authors.lastname: Sugishita
authors.affiliation: Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan.
authors.forename: Bishal
authors.initials: B
authors.lastname: Gyawali
authors.affiliation: Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Shibata
authors.affiliation: Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Shimokata
authors.affiliation: Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Urakawa
authors.affiliation: Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Mitsuma
authors.affiliation: Department of Pathology, National Hospital Organization Nagoya Medical Center, Nagoya, Aichi 460-0008, Japan.
authors.forename: Suzuko
authors.initials: S
authors.lastname: Moritani
authors.affiliation: Department of Ophthalmology, National Hospital Organization Nagoya Medical Center, Nagoya, Aichi 460-0008, Japan.
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Kubota
authors.affiliation: Department of Pathology, National Hospital Organization Nagoya Medical Center, Nagoya, Aichi 460-0008, Japan.
authors.forename: Shu
authors.initials: S
authors.lastname: Ichihara
authors.affiliation: Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ando
keywords: malignant granular cell tumor; orbit; pazopanib