title: Rethinking glutamine addiction.
abstract: Tumours reprogram their metabolism to maximize macromolecule biosynthesis for growth. However, which of the common tumour-associated metabolic activities are critical for proliferation remains unclear. Glutamate-derived glutamine is now shown to satisfy the glutamine needs of glioblastoma, indicating that glutamine anaplerosis is dispensable for growth.
authors.affiliation: UCLA, Molecular and Medical Pharmacology, 34-115 Center for Health Sciences, 650 Charles E. Young Drive South, Los Angeles, California 90095, USA.
authors.forename: Abigail S
authors.initials: AS
authors.lastname: Krall
authors.affiliation: UCLA, Molecular and Medical Pharmacology, 34-115 Center for Health Sciences, 650 Charles E. Young Drive South, Los Angeles, California 90095, USA.
authors.forename: Heather R
authors.initials: HR
authors.lastname: Christofk
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism*; D049109:Cell Proliferation; D005260:Female; D005909:Glioblastoma / Q000378:metabolism*; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism*; D006801:Humans; D008297:Male; D009711:Nucleotides / Q000096:biosynthesis*
chemical_list: D009711:Nucleotides; D005973:Glutamine; D005974:Glutamate-Ammonia Ligase