title: Dietary regulation of adiponectin by direct and indirect lipid activators of nuclear hormone receptors.
abstract: Adiponectin is an adipokine mainly secreted by adipocytes that presents antidiabetic, anti-inflammatory, and antiatherogenic functions. Therefore, modulation of adiponectin expression represents a promising target for prevention or treatment of several diseases including insulin resistance and type II diabetes. Pharmacological agents such as the nuclear hormone receptor synthetic agonists like peroxisome proliferator activated receptor γ agonists are of particular interest in therapeutic strategies due to their ability to increase the plasma adiponectin concentration. Nutritional approaches are also of particular interest, especially in primary prevention, since some active compounds of our diet (notably vitamins, carotenoids, or other essential nutrients) are direct or indirect lipid-activators of nuclear hormone receptors and are modifiers of adiponectin expression and secretion. The aim of the present review is to summarize current knowledge about the nutritional regulation of adiponectin by derivatives of active compounds naturally present in the diet acting as indirect or direct activators of nuclear hormone receptors.
authors.affiliation: Paprika Bioanalytics BT, Debrecen, Hungary.|MTA-DE Public Health Research Group of the Hungarian Academy of Sciences, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.
authors.forename: R
authors.initials: R
authors.lastname: Rühl
authors.affiliation: INRA, Marseille, France.|INSERM, Nutrition, Obésité et Risque Thrombotique, Marseille, France.|Faculté de Médecine, Aix-Marseille Université, Marseille, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Landrier
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000378:metabolism; D000818:Animals; D003924:Diabetes Mellitus, Type 2; D004032:Diet; D004195:Disease Models, Animal; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D005399:Fishes; D005638:Fruit; D006801:Humans; D007333:Insulin Resistance; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism*; D047488:Retinoid X Receptors / Q000235:genetics / Q000378:metabolism; D017747:Seafood; D015398:Signal Transduction; D014675:Vegetables; D014801:Vitamin A / Q000008:administration & dosage; D014807:Vitamin D / Q000008:administration & dosage; D014810:Vitamin E / Q000008:administration & dosage; D014812:Vitamin K / Q000008:administration & dosage
chemical_list: D052242:Adiponectin; D005231:Fatty Acids, Unsaturated; D047495:PPAR gamma; D018160:Receptors, Cytoplasmic and Nuclear; D047488:Retinoid X Receptors; D014801:Vitamin A; D014812:Vitamin K; D014807:Vitamin D; D014810:Vitamin E
keywords: Adiponectin; Adipose tissue; Ligand; Nuclear hormone receptor; Vitamins