title: Incidence of Autoantibodies to C1Q Complement Component in Women with Miscarriages and Autoantibodies to Phospholipids and Chorionic Gonadotropin.
abstract: Autoantibodies to C1q complement component are often detected in patients with autoimmune diseases. The complement system is involved in the pathophysiology of gestosis. The incidence of anti-C1q autoantibodies was studied in women with miscarriages and autoantibodies to phospholipids and chorionic gonadotropin. Serum C3 and C4 complement components and anti-C1Q autoantibodies (IgG) were measured by ELISA. The median levels of C3 and C4 in patients with miscarriages were lower than in healthy women. Anti-C1q autoantibodies were more often found in the patients than in controls; patients with autoantibodies to phospholipids formed a risk group. Median levels of anti-C1q autoantibodies were higher in the patients with autoantibodies to phospholipids and chorionic gonadotropin than in healthy women. Hence, activation of the complement system and hyperproduction of anti-C1q autoantibodies were unfolding in patients with miscarriages, mainly in the patients with autoantibodies to phospholipids.
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia. i_menzinskaya@oparina4.ru.
authors.forename: I V
authors.initials: IV
authors.lastname: Menzhinskaya
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Van'ko
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: M M
authors.initials: MM
authors.lastname: Kashentseva
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: P A
authors.initials: PA
authors.lastname: Kiryushchenkov
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood* / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology*; D006063:Chorionic Gonadotropin / Q000276:immunology*; D015922:Complement C1q / Q000276:immunology*; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D005260:Female; D006801:Humans; D010743:Phospholipids / Q000276:immunology*; D011247:Pregnancy
chemical_list: D001323:Autoantibodies; D006063:Chorionic Gonadotropin; D003176:Complement C3; D003181:Complement C4; D010743:Phospholipids; D015922:Complement C1q
keywords: antiphospholipid autoantibodies; autoantibodies to chorionic gonadotropin; autoantibodies to complement C1q component; miscarriage