title: The anti-bacterial poly(caprolactone)-poly(quaternary ammonium salt) as drug delivery carriers.
abstract: Anti-bacterial materials play significant role in biomedical field. Researches and applications of new anti-bacterial materials are necessary. Novel linear and star-shaped copolymers of poly(caprolactone)-poly(quaternary ammonium salt) (PCL-PJDMA) were synthesized by a combination of ring-opening polymerization and atom transfer radical polymerization. The structures of the copolymers were confirmed by nuclear magnetic resonance ((1)H-NMR) and Fourier transform infrared spectroscopy. The copolymers self-assembled into ball-shaped micelles with low critical micelle concentration (10(-4) ∼ 10(-3) mg/ml). An anti-bacterial drug, triclosan, was chosen as a model drug to investigate the potential application of the copolymers in drug-controlled release. The anti-bacterial experiments against Escherichia coli indicated that all the copolymer micelles had anti-bacterial ability and drug-loaded star-shaped PCL-PJDMA micelles were the best. The slow release of the drug from the drug-loaded micelles prolonged anti-bacterial effect. Therefore, PCL-PJDMA themselves have not only anti-bacterial ability but also the copolymer micelles can be used as carriers for anti-bacterial drugs.
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu, 610065, China.
authors.forename: Mengtian
authors.initials: M
authors.lastname: Leng
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu, 610065, China.
authors.forename: Shaodong
authors.initials: S
authors.lastname: Hu
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu, 610065, China.
authors.forename: Aijing
authors.initials: A
authors.lastname: Lu
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu, 610065, China.
authors.forename: Mengtan
authors.initials: M
authors.lastname: Cai
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu, 610065, China. luoxl_scu@126.com.|State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China. luoxl_scu@126.com.
authors.forename: Xianglin
authors.initials: X
authors.lastname: Luo
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D008823:Micelles; D008826:Microbial Sensitivity Tests; D011091:Polyesters / Q000737:chemistry*; D058105:Polymerization; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D014260:Triclosan / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008823:Micelles; D011091:Polyesters; D000644:Quaternary Ammonium Compounds; C016240:polycaprolactone; D014260:Triclosan
keywords: Amphiphilic copolymer; Anti-bacterial polymer; Anti-bacterial property; Carriers for anti-bacterial drug