title: Parameterization of the Age-Dependent Whole Brain Apparent Diffusion Coefficient Histogram.
abstract: OBJECTIVE
  The distribution of apparent diffusion coefficient (ADC) values in the brain can be used to characterize age effects and pathological changes of the brain tissue. The aim of this study was the parameterization of the whole brain ADC histogram by an advanced model with influence of age considered.
  
  
  METHODS
  Whole brain ADC histograms were calculated for all data and for seven age groups between 10 and 80 years. Modeling of the histograms was performed for two parts of the histogram separately: the brain tissue part was modeled by two Gaussian curves, while the remaining part was fitted by the sum of a Gaussian curve, a biexponential decay, and a straight line.
  
  
  RESULTS
  A consistent fitting of the histograms of all age groups was possible with the proposed model.
  
  
  CONCLUSIONS
  This study confirms the strong dependence of the whole brain ADC histograms on the age of the examined subjects. The proposed model can be used to characterize changes of the whole brain ADC histogram in certain diseases under consideration of age effects.
authors.affiliation: Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Klose
authors.affiliation: Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
authors.forename: Marion
authors.initials: M
authors.lastname: Batra
authors.affiliation: Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Nägele
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D002648:Child; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult