title: Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma.
authors.affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
authors.forename: Thomas
authors.initials: T
authors.lastname: Colley
authors.affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mercado
authors.affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kunori
authors.affiliation: Respiratory Medicine, Glenfield Hospital, University of Leicester, Leicester, United Kingdom.
authors.forename: Christopher
authors.initials: C
authors.lastname: Brightling
authors.affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
authors.forename: Pankaj K
authors.initials: PK
authors.lastname: Bhavsar
authors.affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Barnes
authors.affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom. Electronic address: k.ito@imperial.ac.uk.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ito
mesh_terms: D000107:Acetylation; D000328:Adult; D001249:Asthma / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D050990:GATA3 Transcription Factor / Q000097:blood*; D006801:Humans; D015847:Interleukin-4 / Q000097:blood*; D008297:Male; D012720:Severity of Illness Index; D056564:Sirtuin 1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human; C508598:IL4 protein, human; D015847:Interleukin-4; C447939:SIRT1 protein, human; D056564:Sirtuin 1