title: Aurora Kinases Throughout Plant Development.
abstract: Aurora kinases are evolutionarily conserved key mitotic determinants in all eukaryotes. Yeasts contain a single Aurora kinase, whereas multicellular eukaryotes have at least two functionally diverged members. The involvement of Aurora kinases in human cancers has provided an in-depth mechanistic understanding of their roles throughout cell division in animal and yeast models. By contrast, understanding Aurora kinase function in plants is only starting to emerge. Nevertheless, genetic, cell biological, and biochemical approaches have revealed functional diversification between the plant Aurora kinases and suggest a role in formative (asymmetric) divisions, chromatin modification, and genome stability. This review provides an overview of the accumulated knowledge on the function of plant Aurora kinases as well as some major challenges for the future.
authors.affiliation: Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), 9052 Ghent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.
authors.forename: Annika K
authors.initials: AK
authors.lastname: Weimer
authors.affiliation: Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Stadt Seeland, 06466 Germany.
authors.forename: Dmitri
authors.initials: D
authors.lastname: Demidov
authors.affiliation: Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Stadt Seeland, 06466 Germany.
authors.forename: Inna
authors.initials: I
authors.lastname: Lermontova
authors.affiliation: Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), 9052 Ghent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.
authors.forename: Tom
authors.initials: T
authors.lastname: Beeckman
authors.affiliation: Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), 9052 Ghent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium. Electronic address: daniel.vandamme@psb-vib.ugent.be.
authors.forename: Daniël
authors.initials: D
authors.lastname: Van Damme
mesh_terms: D064127:Aurora Kinases / Q000378:metabolism*; D063245:Plant Development; D010944:Plants / Q000201:enzymology; D011485:Protein Binding; D021381:Protein Transport; D013379:Substrate Specificity
chemical_list: D064127:Aurora Kinases
keywords: Aurora kinases; asymmetry; cell division; mitosis; plant development; spindle bipolarity