title: Formulation and in-vitro evaluation of floating bilayer tablet of lisinopril maleate and metoprolol tartrate.
abstract: The purpose of this study was to introduce the technology for the development of rate-controlled oral drug delivery system to overcome various physiological problems. Several approaches are being used for the purpose of increasing the gastric retentive time, including floating drug delivery system. Gastric floating lisinopril maleate and metoprolol tartrate bilayer tablets were formulated by direct compression method using the sodium starch glycolate, crosscarmellose sodium for IR layer. Eudragit L100, pectin, acacia as sustained release polymers in different ratios for SR metoprolol tartrate layer and sodium bicarbonate, citric acid as gas generating agents for the floating extended release layer. The floating bilayer tablets of lisinopril maleate and metoprolol tartrate were designed to overcome the various problems associated with conventional oral dosage form. Floating tablets were evaluated for floating lag time, drug contents and in-vitro dissolution profile and different kinetic release models were applied. It was clear that the different ratios of polymers affected the drug release and floating time. L2 and M4 showed good drug release profile and floating behavior. The linear regression and model fitting showed that all formulation followed Higuchi model of drug release model except M4 that followed zero order kinetic. From the study it is evident that a promising controlled release by floating bilyer tablets of lisinopril maleate and metoprolol tartrate can be developed successfully.
authors.affiliation: College of Pharmacy, Govt. College University Faisalabad, Pakistan.
authors.forename: Hira
authors.initials: H
authors.lastname: Ijaz
authors.affiliation: College of Pharmacy, Govt. College University Faisalabad, Pakistan.
authors.forename: Junaid
authors.initials: J
authors.lastname: Qureshi
authors.affiliation: University College of Pharmacy, University of the Punjab, Lahore, Pakistan.
authors.forename: Zeeshan
authors.initials: Z
authors.lastname: Danish
authors.affiliation: Faculty of Pharmacy, The University of Lahore, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zaman
authors.affiliation: Pharmacology Department, Faculty of Veterinary Medicine,Suez Canal University, Ismailia, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abdel-Daim
authors.affiliation: Department of Pharmacy, BZU Multan, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Hanif
authors.affiliation: Akhtar Saeed college of Pharmaceutical Sciences, Lahore, Pakistan.
authors.forename: Imran
authors.initials: I
authors.lastname: Waheed
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
authors.forename: Imran Shair
authors.initials: IS
authors.lastname: Mohammad
mesh_terms: D000284:Administration, Oral; D058671:Adrenergic beta-1 Receptor Antagonists / Q000008:administration & dosage / Q000737:chemistry*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D007700:Kinetics; D017706:Lisinopril / Q000008:administration & dosage / Q000737:chemistry*; D008790:Metoprolol / Q000008:administration & dosage / Q000737:chemistry*; D008956:Models, Chemical; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D003692:Delayed-Action Preparations; D005079:Excipients; D013607:Tablets; D017706:Lisinopril; D008790:Metoprolol