title: Macrocerebellum: Volumetric and Diffusion Tensor Imaging Analysis.
abstract: Macrocerebellum is a rare entity characterized by an enlarged cerebellum. We describe a case of a 48-month-old child with macrocerebellum. We performed serial volumetric analysis [total brain volume (TBV) and cerebellar volume] over a period of 4 years. We analyzed the white matter microstructure in the cerebellum using diffusion tensor imaging (DTI). In our patient, we found higher fractional anisotropy (FA) and lower mean diffusivity (MD) in the cerebellar white matter compared to age-matched controls. Our results may represent accelerated myelination secondary to the abnormal cerebellar development.
authors.affiliation: The Johns Hopkins Hospital, School of Medicine, The Russell H. Morgan Department of Radiology and Radiological Science, Division of Neuroradiology, Section of Pediatric Neuroradiology, Baltimore, USA.
authors.forename: Izlem
authors.initials: I
authors.lastname: Izbudak
authors.forename: Niyazi
authors.initials: N
authors.lastname: Acer
authors.forename: Andrea
authors.initials: A
authors.lastname: Poretti
authors.forename: Kazim
authors.initials: K
authors.lastname: Gumus
authors.forename: Gokmen
authors.initials: G
authors.lastname: Zararsiz
mesh_terms: D016880:Anisotropy; D002531:Cerebellum / Q000254:growth & development* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D056324:Diffusion Tensor Imaging; D006801:Humans; D008137:Longitudinal Studies; D008297:Male