title: Modulation effect of the SORL1 gene on functional connectivity density in healthy young adults.
abstract: The sortilin-related receptor 1 (SORL1) gene has been associated with late-onset Alzheimer's disease (LOAD) and structural impairments in several ethnic populations. However, how this gene affects brain function properties remains unclear. We investigated associations of SORL1 rs2070045 with functional connectivity density (FCD) in healthy young adults. This single-nucleotide polymorphism was selected because it is the SORL1 variant that has been frequently associated with LOAD in several populations, including the Chinese Han population. A total of 275 healthy young Chinese Han subjects with successful genotyping and MRI examinations were included. The effect of SORL1 rs2070045 was explored using a voxel-wise FCD analysis. A significant effect of SORL1 rs2070045 on the FCD was found in the right inferior temporal gyrus. The risk G allele carriers of the rs2070045 exhibited a lower FCD than the protective TT carriers. This effect was independent of the status of apolipoprotein E. This study provides the first evidence that the SORL1 gene is associated with brain FCD differences in healthy young adults. In the genetic risk subjects, connectivity impairment already starts during young adulthood, which may predispose the risk allele carriers to be susceptible to LOAD after several decades.
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China.
authors.forename: Junlin
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China.
authors.forename: Huaigui
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China.
authors.forename: Lixue
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China.
authors.forename: Jiayuan
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Qin
authors.affiliation: Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.affiliation: Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China. chunshuiyu@tijmu.edu.cn.
authors.forename: Chunshui
authors.initials: C
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D005838:Genotype; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000235:genetics* / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000502:physiology*; D008568:Memory / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D026502:LDL-Receptor Related Proteins; D026901:Membrane Transport Proteins; C102582:SORL1 protein, human
keywords: Linkage disequilibrium; Neuroimaging; SNPs; SORL1; fMRI