title: Recurrent meningioma with malignant transformation: a case report and literature review.
abstract: Meningiomas are common and mostly benign intracranial tumors, but may show a histological progression to malignancy. The mechanisms of malignant transformation remain unclear. Malignant meningiomas usually bear a high recurrence rate and unfavorable prognosis, and multiple surgical resections are required for the treatment. We report on a case of 51-year-old woman with a histologically benign intracranial meningioma. The patient had undergone multiple tumor resections and radiotherapy treatments. After multiple resections, the tumor demonstrated malignant transformation. A rapid tumor growth resulted in extensive tumor invasion of dura, brain and nasal sinus. Impaired brain function and subsequent intracranial hypertension caused serious headache, vomiting and coma. The patient survived 5 years following initial presentation. 3 subtotal resections of meningioma were performed. Radiotherapy was shown to be relatively ineffective during the course. The treatment strategies of recurrent meningiomas are briefly reviewed.
authors.affiliation: Department of Neurosurgery, Wuhan Central Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology Wuhan 430014, Hubei, P. R. China.
authors.forename: Junwen
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Wuhan Central Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology Wuhan 430014, Hubei, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pathology, Wuhan Central Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology Wuhan 430014, Hubei, P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Luo
authors.affiliation: Department of Neurosurgery, Wuhan Central Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology Wuhan 430014, Hubei, P. R. China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Wuhan Central Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology Wuhan 430014, Hubei, P. R. China.
authors.forename: Zuojun
authors.initials: Z
authors.lastname: Xiong
authors.affiliation: Department of Neurosurgery, Wuhan Central Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology Wuhan 430014, Hubei, P. R. China.
authors.forename: Mingbo
authors.initials: M
authors.lastname: Fang
authors.affiliation: Department of Neurosurgery, Wuhan Central Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology Wuhan 430014, Hubei, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
keywords: Meningioma; malignant transformation; recurrence; surgery