title: A metabolomic study on the biological effects of metal pollutions in oysters Crassostrea sikamea.
abstract: Metal pollution has become a great threat to organisms in the estuaries in South China. In the present study, the oysters Crassostrea sikamea were collected from one clean (Jiuzhen) and five metal polluted sites (Baijiao, Fugong, Gongqian, Jinshan and Songyu). The tissue metal concentrations in oysters indicated that the five metal sites were polluted by several metals, including Cr, Ni, Co, Cu, Zn, Ag, Cd and Pb with different patterns. Especially, Cu and Zn were the major contaminants in Baijiao, Fugong and Jinshan sites. The metabolic responses in oysters C. sikamea indicated that the metal pollutions in BJ, FG, JS and SY sites induced disturbances in osmotic regulation and energy metabolism via different metabolic pathways. However, the metal pollution in GQ site mainly influenced the osmotic regulation in the oysters C. sikamea. This study demonstrates that NMR-based metabolomics is useful to characterize metabolic responses induced by metal pollution.
authors.affiliation: Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS), Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes, YICCAS, Yantai 264003, PR China.
authors.forename: Chenglong
authors.initials: C
authors.lastname: Ji
authors.affiliation: Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS), Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes, YICCAS, Yantai 264003, PR China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS), Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes, YICCAS, Yantai 264003, PR China. Electronic address: hfwu@yic.ac.cn.
authors.forename: Huifeng
authors.initials: H
authors.lastname: Wu
authors.affiliation: Key Laboratory of the Coastal and Wetland Ecosystems, Ministry of Education, College of Environment and Ecology, Xiamen University, Xiamen 361102, PR China.
authors.forename: Qiaoguo
authors.initials: Q
authors.lastname: Tan
authors.affiliation: Division of Life Science, The Hong Kong University of Science and Technology (HKUST), Clearwater Bay, Kowloon, Hong Kong.
authors.forename: Wen-Xiong
authors.initials: WX
authors.lastname: Wang
mesh_terms: D000818:Animals; D002681:China; D049896:Crassostrea / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects; D004784:Environmental Monitoring; D063366:Estuaries; D053858:Metabolic Networks and Pathways / Q000187:drug effects; D055432:Metabolomics; D019216:Metals, Heavy / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity; D009995:Osmosis / Q000187:drug effects; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity
chemical_list: D019216:Metals, Heavy; D014874:Water Pollutants, Chemical
keywords: (1)H NMR; Crassostrea sikamea; Metabolomics; Metal pollution