title: T Cells Target Pancreatic Tumors.
abstract: Researchers have generated engineered T cells that home in on mesothelin, a protein produced in large amounts by pancreatic tumors. In mice, the T cells entered pancreatic tumors and destroyed cancer cells. Repeated infusions of the T cells nearly doubled survival times in the animals.
authors.forename: Mitch
authors.initials: M
authors.lastname: Leslie
mesh_terms: D000818:Animals; D060846:Cell Engineering; D058851:GPI-Linked Proteins / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy; D000090204:Mesothelin; D051379:Mice; D010190:Pancreatic Neoplasms / Q000276:immunology / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation*; D016896:Treatment Outcome; D023041:Xenograft Model Antitumor Assays
chemical_list: D058851:GPI-Linked Proteins; C000715528:Msln protein, mouse; D000090204:Mesothelin