title: The role of lysosome in cell death regulation.
abstract: Lysosome is a highly membrane-bound organelle which possesses a sequence of biological functions including protein degradation, cell signal transduction, plasma membrane repairment, homoeostasis, and autophagy. The lysosome contains more than 50 soluble acid hydrolases, and the acidification of lysosome is the most important biological characteristic. The integrity of lysosome is of vital importance. During the past few years, it was reported that the destabilization of lysosomal membrane can result in the release of lysosomal contents into cytosol and trigger cell death in a caspase-dependent or caspase-independent pathway. Lysosome functions at the late stage of autophagy and degrades cellular components delivered by autophagosome, which is a complicated process. The present article will summarize the current knowledge on the role of lysosome in cell death regulation and the underlying mechanisms.
authors.affiliation: Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, Jilin University, Changchun, 130021, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Yu
authors.affiliation: Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, Jilin University, Changchun, 130021, China.
authors.forename: Zongyan
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, Jilin University, Changchun, 130021, China.
authors.forename: Benli
authors.initials: B
authors.lastname: Wang
authors.affiliation: Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, Jilin University, Changchun, 130021, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, Jilin University, Changchun, 130021, China.
authors.forename: Yufei
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, Jilin University, Changchun, 130021, China. shmm2001@126.com.|Department Cancer Care, University of Manitoba, Winnipeg, MB, R3T 3T2, Canada. shmm2001@126.com.
authors.forename: Shumei
authors.initials: S
authors.lastname: Ma
authors.affiliation: Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, Jilin University, Changchun, 130021, China. liuxd2014@126.com.|Center for Radiological Research, Columbia University, New York, NY, 10032, USA. liuxd2014@126.com.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D016923:Cell Death / Q000502:physiology*; D006801:Humans; D008247:Lysosomes / Q000502:physiology*; D009369:Neoplasms / Q000503:physiopathology
keywords: Apoptosis; Autophagy; Cancer therapy; Lysosome; Mitochondria