title: Serum Superoxide Dismutase Is Associated with Vascular Structure and Function in Hypertensive and Diabetic Patients.
abstract: Oxidative stress is associated with cardiac and vascular defects leading to hypertension and atherosclerosis, being superoxide dismutase (SOD) one of the main intracellular antioxidant defence mechanisms. Although several parameters of vascular function and structure have a predictive value for cardiovascular morbidity-mortality in hypertensive patients, there are no studies on the involvement of SOD serum levels with these vascular parameters. Thus, we assessed if SOD serum levels are correlated with parameters of vascular function and structure and with cardiovascular risk in hypertensive and type 2 diabetic patients. We enrolled 255 consecutive hypertensive and diabetic patients and 52 nondiabetic and nonhypertensive controls. SOD levels were measured with an enzyme-linked immunosorbent assay kit. Vascular function and structure were evaluated by pulse wave velocity, augmentation index, ambulatory arterial stiffness index, and carotid intima-media thickness. We detected negative correlations between SOD and pressure wave velocity, peripheral and central augmentation index and ambulatory arterial stiffness index, pulse pressure, and plasma HDL-cholesterol, as well as positive correlations between SOD and plasma uric acid and triglycerides. Our study shows that SOD is a marker of cardiovascular alterations in hypertensive and diabetic patients, since changes in its serum levels are correlated with alterations in vascular structure and function.
authors.affiliation: Research Unit, Primary Care Centre La Alamedilla, SACYL, Avenida de los Comuneros 27, 37003 Salamanca, Spain.
authors.forename: Manuel A
authors.initials: MA
authors.lastname: Gómez-Marcos
authors.affiliation: Institute of Biomedical Research of Salamanca (IBSAL), Renal and Cardiovascular Pathophysiology Unit, Department of Physiology and Pharmacology, University of Salamanca, Avenida Campo Charro s/n, 37007 Salamanca, Spain.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Blázquez-Medela
authors.affiliation: Institute of Biomedical Research of Salamanca (IBSAL), Renal and Cardiovascular Pathophysiology Unit, Department of Physiology and Pharmacology, University of Salamanca, Avenida Campo Charro s/n, 37007 Salamanca, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Gamella-Pozuelo
authors.affiliation: Research Unit, Primary Care Centre La Alamedilla, SACYL, Avenida de los Comuneros 27, 37003 Salamanca, Spain.
authors.forename: José I
authors.initials: JI
authors.lastname: Recio-Rodriguez
authors.affiliation: Research Unit, Primary Care Centre La Alamedilla, SACYL, Avenida de los Comuneros 27, 37003 Salamanca, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: García-Ortiz
authors.affiliation: Institute of Biomedical Research of Salamanca (IBSAL), Renal and Cardiovascular Pathophysiology Unit, Department of Physiology and Pharmacology, University of Salamanca, Avenida Campo Charro s/n, 37007 Salamanca, Spain ; Institute of Studies in Health Sciences of Castilla y León (IECSCYL), Research Unit, University Hospital of Salamanca, Paseo San Vicente 58-182, 37007 Salamanca, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Martínez-Salgado
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D063177:Pulse Wave Analysis; D013482:Superoxide Dismutase / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D014280:Triglycerides; D014527:Uric Acid; D013482:Superoxide Dismutase