title: More Frequent than Desired: Midgut Stem Cell Somatic Mutations.
abstract: The accumulation of somatic mutations in adult stem cells contributes to the decline of tissue functions and cancer initiation. In this issue of Cell Stem Cell, Siudeja et al. (2015) investigate the rate and mechanism of naturally occurring mutations in Drosophila midgut intestinal stem cells during aging and find high-frequency mutations arising from multiple mechanisms.
authors.affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: tony.ip@umassmed.edu.
authors.forename: Y Tony
authors.initials: YT
authors.lastname: Ip
mesh_terms: D053687:Adult Stem Cells / Q000378:metabolism*; D000818:Animals; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D009154:Mutation; D015398:Signal Transduction / Q000235:genetics; D013234:Stem Cells / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins