title: Deciphering Genomic Underpinnings of Quantitative MRI-based Radiomic Phenotypes of Invasive Breast Carcinoma.
abstract: Magnetic Resonance Imaging (MRI) has been routinely used for the diagnosis and treatment of breast cancer. However, the relationship between the MRI tumor phenotypes and the underlying genetic mechanisms remains under-explored. We integrated multi-omics molecular data from The Cancer Genome Atlas (TCGA) with MRI data from The Cancer Imaging Archive (TCIA) for 91 breast invasive carcinomas. Quantitative MRI phenotypes of tumors (such as tumor size, shape, margin, and blood flow kinetics) were associated with their corresponding molecular profiles (including DNA mutation, miRNA expression, protein expression, pathway gene expression and copy number variation). We found that transcriptional activities of various genetic pathways were positively associated with tumor size, blurred tumor margin, and irregular tumor shape and that miRNA expressions were associated with the tumor size and enhancement texture, but not with other types of radiomic phenotypes. We provide all the association findings as a resource for the research community (available at http://compgenome.org/Radiogenomics/). These findings pave potential paths for the discovery of genetic mechanisms regulating specific tumor phenotypes and for improving MRI techniques as potential non-invasive approaches to probe the cancer molecular status.
authors.affiliation: Program of Computational Genomics &Medicine, NorthShore University HealthSystem, Evanston, Illinois, USA.
authors.forename: Yitan
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Radiology, The University of Chicago, Chicago, Illinois, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: School of Public Health, Fudan University, Shanghai, P.R. China.
authors.forename: Wentian
authors.initials: W
authors.lastname: Guo
authors.affiliation: Department of Radiology, The University of Chicago, Chicago, Illinois, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Drukker
authors.affiliation: Department of Radiology, The University of Chicago, Chicago, Illinois, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Lan
authors.affiliation: Department of Radiology, The University of Chicago, Chicago, Illinois, USA.
authors.forename: Maryellen L
authors.initials: ML
authors.lastname: Giger
authors.affiliation: Program of Computational Genomics &Medicine, NorthShore University HealthSystem, Evanston, Illinois, USA.|Department of Public Health Sciences, The University of Chicago, Chicago, Illinois, USA.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ji
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D015894:Genome, Human; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009154:Mutation / Q000235:genetics; D009361:Neoplasm Invasiveness; D010641:Phenotype; D011859:Radiography; D014158:Transcription, Genetic
chemical_list: D035683:MicroRNAs