title: Cytidine 5'-Diphosphocholine (Citicoline) in Glaucoma: Rationale of Its Use, Current Evidence and Future Perspectives.
abstract: Cytidine 5'-diphosphocholine or citicoline is an endogenous compound that acts in the biosynthetic pathway of phospholipids of cell membranes, particularly phosphatidylcholine, and it is able to increase neurotrasmitters levels in the central nervous system. Citicoline has shown positive effects in Parkinson's disease and Alzheimer's disease, as well as in amblyopia. Glaucoma is a neurodegenerative disease currently considered a disease involving ocular and visual brain structures. Neuroprotection has been proposed as a valid therapeutic option for those patients progressing despite a well-controlled intraocular pressure, the main risk factor for the progression of the disease. The aim of this review is to critically summarize the current evidence about the effect of citicoline in glaucoma.
authors.affiliation: IRCCS-Fondazione GB Bietti, Via Livenza, 3, 00198 Rome, Italy. gloriaroberti82@gmail.com.
authors.forename: Gloria
authors.initials: G
authors.lastname: Roberti
authors.affiliation: IRCCS-Fondazione GB Bietti, Via Livenza, 3, 00198 Rome, Italy. lucia.tanga@gmail.com.
authors.forename: Lucia
authors.initials: L
authors.lastname: Tanga
authors.affiliation: IRCCS-Fondazione GB Bietti, Via Livenza, 3, 00198 Rome, Italy. manuele_michelessi@yahoo.it.
authors.forename: Manuele
authors.initials: M
authors.lastname: Michelessi
authors.affiliation: DSMC, Università degli studi di Brescia, USVD "Centro per lo studio del Glaucoma" P.le Spedali Civili, 1, 25123 Brescia, Italy. luciano.quaranta@unibs.it.
authors.forename: Luciano
authors.initials: L
authors.lastname: Quaranta
authors.affiliation: IRCCS-Fondazione GB Bietti, Via Livenza, 3, 00198 Rome, Italy. vmparisi@gmail.com.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Parisi
authors.affiliation: DSCMT, Università di Roma Tor Vergata, Viale Oxford 81, 00133 Rome, Italy. gianlucamanni53@gmail.com.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Manni
authors.affiliation: IRCCS-Fondazione GB Bietti, Via Livenza, 3, 00198 Rome, Italy. oddonef@gmail.com.
authors.forename: Francesco
authors.initials: F
authors.lastname: Oddone
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000209:etiology; D003566:Cytidine Diphosphate Choline / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D005123:Eye / Q000187:drug effects; D005901:Glaucoma / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D009883:Ophthalmic Solutions / Q000494:pharmacology / Q000627:therapeutic use; D012165:Retinal Ganglion Cells / Q000187:drug effects / Q000378:metabolism
chemical_list: D018696:Neuroprotective Agents; D009883:Ophthalmic Solutions; D003566:Cytidine Diphosphate Choline
keywords: citicoline; glaucoma; neuroprotection; retinal ganglion cells