title: [MALT Lymphoma of the Conjunctiva in a 13-year old Child--5-Year Relapse-free Follow-up Following Antibiotic Treatment].
abstract: METHODS
  In February 2007, a 13-year old boy presented with a livid tumour in the lower conjunctival fornix of the left eye. OPHTHALMOLOGICAL FINDINGS: The tumor was salmon-coloured, bulging and elastic and filled the whole lower conjunctival fornix of the left eye. There was no other pathological finding in the left eye. Uncorrected visual acuity was 20/20. Intraocular pressure was 12 mmHg. The eye was fully motile.
  
  
  METHODS
  Incisional biopsy was performed in February 2007. The tumor was histologically an extranodal MALT lymphoma. DNA testing for Chlamydophila trachomatis and Chlamydophila pneumonia was negative. Systemic treatment was started with doxycycline (200 mg daily). After six weeks, the tumour was slightly smaller. Azithromycin 500 mg once a week was added. 18 months after initiation of the treatment, the tumour had completely regressed. A second sample taking in the former tumor area showed tumor-free conjunctiva and subconjunctival tissue. As a precaution, the combined antibiotic therapy was continued for 10 months and the patient was followed for five more years. The lymphoma did not relapse in the conjunctiva and orbit or in the whole body.
  
  
  CONCLUSIONS
  We showed that extranodal MALT lymphomas of the conjunctiva can be successfully treated with antibiotics alone. At the start of therapy, the child was 13 years old. To our knowledge, this patient is the first child in Germany and one of the first in the world with ocular adnexal lymphoma who could be successfully treated with combined antibiotic therapy and who could be followed up for 5 years without relapse. Thus, we could avoid radiotherapy or chemotherapy in childhood and eliminate the risk of a therapy-induced secondary malignancy.
authors.affiliation: Klinik für Augenheilkunde, Dietrich-Bonhoeffer-Klinikum, Neubrandenburg.
authors.forename: H
authors.initials: H
authors.lastname: Höh
authors.affiliation: Klinik für Kinder- und Jugendmedizin, Dietrich-Bonhoeffer-Klinikum, Neubrandenburg.
authors.forename: S
authors.initials: S
authors.lastname: Armbrust
authors.affiliation: Institut für Pathologie, Dietrich-Bonhoeffer-Klinikum, Neubrandenburg.
authors.forename: T
authors.initials: T
authors.lastname: Decker
authors.affiliation: Klinik für Augenheilkunde, Dietrich-Bonhoeffer-Klinikum, Neubrandenburg.
authors.forename: U
authors.initials: U
authors.lastname: Holland
authors.affiliation: Klinik für Radiologie und Neuroradiologie, Dietrich-Bonhoeffer-Klinikum, Neubrandenburg.
authors.forename: S
authors.initials: S
authors.lastname: Balschat
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D017963:Azithromycin / Q000008:administration & dosage*; D003230:Conjunctival Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D004318:Doxycycline / Q000008:administration & dosage*; D004359:Drug Therapy, Combination / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D018442:Lymphoma, B-Cell, Marginal Zone / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin; D004318:Doxycycline