title: Effects of rate (0.3-40/s) on simultaneously recorded auditory brainstem, middle and late responses using deconvolution.
abstract: OBJECTIVE
  Auditory evoked potentials (AEPs) are typically acquired in either transient (low-rate) or steady state (high-rate) conditions. This study utilizes deconvolution to obtain transient responses over a range of rates from 0.3 to 40/s, to establish a rate profile of transient responses employing uniform recording conditions.
  
  
  METHODS
  Deconvolution is used to obtain transient responses from quasi steady state recordings for rates 3.5-40/s, and components are scored and waveform morphologies are compared across rates.
  
  
  RESULTS
  All component latencies remain stable across all rates other than P2, which decreases for rates up to 3.5/s. Amplitudes for brainstem (V, Na), middle latency (Pa, Nb), and late (Pb/P1, N1 and P2) responses increased for rates below 1, 2 and 3.5/s, respectively. Rates between 3.5 and 25/s undergo a gradual morphology transition, above which oscillations begin to occur after 100 ms.
  
  
  CONCLUSIONS
  Auditory brainstem, middle and late latency components other than P2 show stable latencies across 0.3-40/s with varying amplitude rate dependencies.
  
  
  CONCLUSIONS
  Obtaining a transient response rate profile utilizing uniform acquisition parameters is useful for an improved understanding of how individual AEP components interact with stimulation rate, and can provide a more comprehensive assessment of the ascending auditory pathway and primary auditory cortices.
authors.affiliation: Department of Biomedical Engineering, University of Miami, P.O. Box 248294, Coral Gables, FL 33124, USA.
authors.forename: Fred
authors.initials: F
authors.lastname: Holt
authors.affiliation: Department of Biomedical Engineering, University of Miami, P.O. Box 248294, Coral Gables, FL 33124, USA; Departments of Otolaryngology, Pediatrics and Neuroscience, School of Medicine, University of Miami, Miami, FL, USA. Electronic address: oozdamar@miami.edu.
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Özdamar
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods*; D000328:Adult; D001303:Auditory Cortex / Q000502:physiology*; D001306:Auditory Pathways / Q000502:physiology; D004569:Electroencephalography / Q000379:methods*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000502:physiology*; D013997:Time Factors; D055815:Young Adult
keywords: Adaptation; Auditory evoked potentials; Chirp; Deconvolution; Rate effects; Transient response