title: Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population.
abstract: The aim of this study was to investigate whether XRCC3 Thr241Met polymorphism could affect the development of osteosarcoma in a Chinese population. A total of 152 osteosarcoma patients and 304 health control subjects were included in our study. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was applied to assess the XRCC3 Thr241Met gene polymorphism. By conditional logistic regression analysis, we found that TT genotype of XRCC3 Thr241Met was associated with increased risk of osteosarcoma in codominant model (OR = 2.53, 95% CI = 1.28-5.39). Moreover, XRCC3 Thr241Met gene polymorphism was correlated with an elevated increased risk of osteosarcoma in dominant (OR = 1.55, 95% CI = 1.03-2.34) and recessive models (OR = 2.30, 95% CI = 1.16-4.56). In conclusion, we found that XRCC3 Thr241Met gene polymorphism was associated with increased risk of osteosarcoma in codominant, dominant and recessive models.
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University Weihui, China.
authors.forename: Libin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University Weihui, China.
authors.forename: Yongbo
authors.initials: Y
authors.lastname: An
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University Weihui, China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University Weihui, China.
authors.forename: Tan
authors.initials: T
authors.lastname: Lu
authors.affiliation: Department of Health and Social Behavior, West China School of Public Health, Sichuan University Chengdu, China.
authors.forename: Shujuan
authors.initials: S
authors.lastname: Yang
mesh_terms: D044466:Asian People / Q000235:genetics*; D001859:Bone Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055815:Young Adult
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3
keywords: Chinese population; XRCC3 Thr241Met; osteosarcoma; polymorphism