title: Changes in Pulmonary Function After Stereotactic Body Radiotherapy and After Surgery for Stage I and II Non-small Cell Lung Cancer, a Description of Two Cohorts.
abstract: OBJECTIVE
  To evaluate changes in pulmonary function tests (PFTs) at different follow-up durations after stereotactic body radiotherapy (SBRT) and surgery in stage I and II non-small-cell lung cancer (NSCLC).
  
  
  METHODS
  Differences between pre-treatment- and follow-up PFTs were analyzed in 93 patients treated with surgery and 30 patients treated with SBRT for NSCLC. Follow-up durations were categorized into: early (0-9 months), middle (10-21 months) and late (≥22 months). Wilcoxon signed-rank test was used to analyze differences between pre-treatment and follow-up PFTs.
  
  
  RESULTS
  Forced expiratory volume in one second, forced vital capacity and diffusion capacity for carbon monoxide corrected for the actual hemoglobin level significantly diminished after surgery for all follow-up durations: 11-17% of predicted values. After SBRT, PFTs remained stable, but a declining trend of 6% (p=0.1) was observed after 22 months.
  
  
  CONCLUSIONS
  SBRT might lead to less treatment-related toxicity measured by PFTs than surgery in both the short and long term.
authors.affiliation: Department of Pulmonology, St. Antonius Hospital, Nieuwegein, the Netherlands.
authors.forename: Leonie
authors.initials: L
authors.lastname: Alberts
authors.affiliation: Department of Radiotherapy, University Medical Center, Utrecht, the Netherlands.
authors.forename: Sherif Y
authors.initials: SY
authors.lastname: El Sharouni
authors.affiliation: Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein, the Netherlands.
authors.forename: Frederik N
authors.initials: FN
authors.lastname: Hofman
authors.affiliation: Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein, the Netherlands.
authors.forename: Bart P
authors.initials: BP
authors.lastname: Van Putte
authors.affiliation: Department of Pulmonology, St. Antonius Hospital, Nieuwegein, the Netherlands.
authors.forename: Ellen
authors.initials: E
authors.lastname: Tromp
authors.affiliation: Department of Radiotherapy, University Medical Center, Utrecht, the Netherlands.
authors.forename: Marco
authors.initials: M
authors.lastname: Van Vulpen
authors.affiliation: Department of Pulmonology, St. Antonius Hospital, Nieuwegein, the Netherlands.
authors.forename: Elisabeth A
authors.initials: EA
authors.lastname: Kastelijn
authors.affiliation: Department of Pulmonology, St. Antonius Hospital, Nieuwegein, the Netherlands f.schramel@antoniusziekenhuis.nl.
authors.forename: Franz M N H
authors.initials: FM
authors.lastname: Schramel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016634:Radiosurgery / Q000379:methods*; D012129:Respiratory Function Tests / Q000379:methods*; D012189:Retrospective Studies
keywords: Stage I and II non-small-cell lung cancer; pulmonary function; stereotactic body radiation; surgery