title: Lack of association between the aryl hydrocarbon receptor rs2066853 polymorphism and breast cancer: A meta-analysis on Ahr polymorphism and breast cancer.
abstract: Published data regarding the association between aryl hydrocarbon receptor (Ahr) rs2066853 polymorphism and the risk of breast cancer shows conflicting results. We performed a meta-analysis on 2999 patients and 3050 controls from three related case-control studies to estimate the association between Ahr rs2066853 polymorphism and the risk of breast cancer. The protocol was approved by the Institutional Animal Care and Use Committee (IACUC) at the University of Florida (America NIH Publication No. 86-231985 Revision). According to the three eligible populations, the odds ratios (ORs), 95% confidence intervals (CIs) on the risk of breast cancer for the genotypes GA vs GG, AA vs GG, and A vs G were 1.06 (0.81-1.40), 0.96 (0.81-1.13), and 1.02 (0.85-1.22), respectively. The OR (95%CI) for GA + AA vs GG was 1.05 (0.80-1.37). Furthermore, after multi-variates adjustment, the ORs (95%CIs) were 1.05 (0.80-1.38) for GA vs GG, and 0.92 (0.76-1.10) for AA vs GG. This meta-analysis suggests that Ahr (rs2066853) polymorphism would not modify the risk of breast cancer. However, further research should be conducted to provide more evidence.
authors.affiliation: Department of Internal Medicine-Oncology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Surgical Oncology, Chinese People's Liberation Army Hospital, Beijing,China.
authors.forename: H Z
authors.initials: HZ
authors.lastname: Qin
authors.affiliation: Department of Internal Medicine-Oncology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Song
authors.affiliation: Department of Internal Medicine-Oncology, Chinese PLA General Hospital, Beijing, China.
authors.forename: X D
authors.initials: XD
authors.lastname: Wu
authors.affiliation: Department of Internal Medicine-Oncology, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing,China jianhuazhudoc@yeah.net.
authors.forename: J H
authors.initials: JH
authors.lastname: Zhu
mesh_terms: D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics*
chemical_list: D018336:Receptors, Aryl Hydrocarbon