title: Various neurocognitive deficits and conversion risk in individuals at clinical high risk for psychosis.
abstract: Individuals at clinical high risk for psychosis (CHR) exhibit neurocognitive deficits in multiple domains. The aim of this study is to investigate whether several components of neurocognition are predictive of conversion to psychosis.
  
  
  
  Fifty-two CHR individuals were assessed with the Structured Interview for Psychosis Risk Syndromes and completed a battery of neurocognitive tests at baseline including measures of executive functioning, attention, working memory, processing speed and reaction time. Neurocognitive functioning at baseline was scored based on an external normative control group. Most subjects were followed for 2.5 years to determine conversion status.
  
  
  
  Significant differences in neurocognitive functioning between CHR individuals and the control group were present in all domains. Twenty-six per cent of the participants converted to psychosis within 9.8 (standard deviation = 8.0) months on average (median 9 months), but there were no significant differences in neurocognition converters and non-converters.
  
  
  
  Individuals at CHR have deficits in neurocognitive functioning, but such deficits do not appear to be related to conversion risk.
authors.affiliation: Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, New York, USA.
authors.forename: Kees
authors.initials: K
authors.lastname: Mourik
authors.affiliation: Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, New York, USA.
authors.forename: Paula
authors.initials: P
authors.lastname: Decrescenzo
authors.affiliation: Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, New York, USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Brucato
authors.affiliation: Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, New York, USA.
authors.forename: Kelly E
authors.identifier: 0000-0002-9247-5980
authors.initials: KE
authors.lastname: Gill
authors.affiliation: Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, New York, USA.
authors.forename: Leigh
authors.initials: L
authors.lastname: Arndt
authors.affiliation: Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, New York, USA.
authors.forename: David
authors.initials: D
authors.lastname: Kimhy
authors.affiliation: Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, New York, USA.
authors.forename: John G
authors.initials: JG
authors.lastname: Keilp
authors.affiliation: Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, New York, USA.
authors.forename: Ragy R
authors.initials: RR
authors.lastname: Girgis
mesh_terms: D003072:Cognition Disorders / Q000150:complications / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D062706:Prodromal Symptoms; D011618:Psychotic Disorders / Q000150:complications / Q000175:diagnosis*; D055815:Young Adult
keywords: cognition; conversion; neurocognition; prodromal; psychosis