title: Concurrent sound segregation impairments in schizophrenia: The contribution of auditory-specific and general cognitive factors.
abstract: The present study sought to test whether perceptual segregation of concurrently played sounds is impaired in schizophrenia (SZ), whether impairment in sound segregation predicts difficulties with a real-world speech-in-noise task, and whether auditory-specific or general cognitive processing accounts for sound segregation problems. Participants with SZ and healthy controls (HCs) performed a mistuned harmonic segregation task during recording of event-related potentials (ERPs). Participants also performed a brief speech-in-noise task. Participants with SZ showed deficits in the mistuned harmonic task and the speech-in-noise task, compared to HCs. No deficit in SZ was found in the ERP component related to mistuned harmonic segregation at around 150ms (the object-related negativity or ORN), but instead showed a deficit in processing at around 400ms (the P4 response). However, regression analyses showed that indexes of education level and general cognitive function were the best predictors of sound segregation difficulties, suggesting non-auditory specific causes of concurrent sound segregation problems in SZ.
authors.affiliation: Department of Psychology, University of Nevada, Las Vegas, 4505 S. Maryland Parkway, MS 5030, Las Vegas, NV, USA.
authors.forename: Erin M
authors.initials: EM
authors.lastname: Ramage
authors.affiliation: Department of Psychology, University of Nevada, Las Vegas, 4505 S. Maryland Parkway, MS 5030, Las Vegas, NV, USA.
authors.forename: Nedka
authors.initials: N
authors.lastname: Klimas
authors.affiliation: Department of Psychology, University of Nevada, Las Vegas, 4505 S. Maryland Parkway, MS 5030, Las Vegas, NV, USA.
authors.forename: Sally J
authors.initials: SJ
authors.lastname: Vogel
authors.affiliation: Department of Psychology, University of Nevada, Las Vegas, 4505 S. Maryland Parkway, MS 5030, Las Vegas, NV, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Vertinski
authors.affiliation: Department of Psychology, University of Nevada, Las Vegas, 4505 S. Maryland Parkway, MS 5030, Las Vegas, NV, USA.
authors.forename: Breanne D
authors.initials: BD
authors.lastname: Yerkes
authors.affiliation: Department of Psychology, University of Nevada, Las Vegas, 4505 S. Maryland Parkway, MS 5030, Las Vegas, NV, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Flores
authors.affiliation: Department of Psychology, University of Nevada, Las Vegas, 4505 S. Maryland Parkway, MS 5030, Las Vegas, NV, USA.
authors.forename: Griffin P
authors.initials: GP
authors.lastname: Sutton
authors.affiliation: Department of Psychology, University of Nevada, Las Vegas, 4505 S. Maryland Parkway, MS 5030, Las Vegas, NV, USA.
authors.forename: Erik N
authors.initials: EN
authors.lastname: Ringdahl
authors.affiliation: Department of Psychology, University of Nevada, Las Vegas, 4505 S. Maryland Parkway, MS 5030, Las Vegas, NV, USA.
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Allen
authors.affiliation: Department of Psychology, University of Nevada, Las Vegas, 4505 S. Maryland Parkway, MS 5030, Las Vegas, NV, USA. Electronic address: joel.snyder@unlv.edu.
authors.forename: Joel S
authors.initials: JS
authors.lastname: Snyder
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D003071:Cognition; D004522:Educational Status; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012044:Regression Analysis; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*; D012565:Schizophrenic Psychology
keywords: Auditory scene analysis; Event-related brain potentials; Hallucinations; Mistuned harmonic segregation; Speech-in-noise