title: Constant mortality and fertility over age in Hydra.
abstract: Senescence, the increase in mortality and decline in fertility with age after maturity, was thought to be inevitable for all multicellular species capable of repeated breeding. Recent theoretical advances and compilations of data suggest that mortality and fertility trajectories can go up or down, or remain constant with age, but the data are scanty and problematic. Here, we present compelling evidence for constant age-specific death and reproduction rates in Hydra, a basal metazoan, in a set of experiments comprising more than 3.9 million days of observations of individual Hydra. Our data show that 2,256 Hydra from two closely related species in two laboratories in 12 cohorts, with cohort age ranging from 0 to more than 41 y, have extremely low, constant rates of mortality. Fertility rates for Hydra did not systematically decline with advancing age. This falsifies the universality of the theories of the evolution of aging that posit that all species deteriorate with age after maturity. The nonsenescent life history of Hydra implies levels of maintenance and repair that are sufficient to prevent the accumulation of damage for at least decades after maturity, far longer than the short life expectancy of Hydra in the wild. A high proportion of stem cells, constant and rapid cell turnover, few cell types, a simple body plan, and the fact that the germ line is not segregated from the soma are characteristics of Hydra that may make nonsenescence feasible. Nonsenescence may be optimal because lifetime reproduction may be enhanced more by extending adult life spans than by increasing daily fertility.
authors.affiliation: Max Planck Institute for Demographic Research, 18057 Rostock, Germany;
authors.forename: Ralf
authors.initials: R
authors.lastname: Schaible
authors.affiliation: Max Planck Institute for Demographic Research, 18057 Rostock, Germany;
authors.forename: Alexander
authors.initials: A
authors.lastname: Scheuerlein
authors.affiliation: Max Planck Institute for Demographic Research, 18057 Rostock, Germany;
authors.forename: Maciej J
authors.initials: MJ
authors.lastname: Dańko
authors.affiliation: Max Planck Institute for Demographic Research, 18057 Rostock, Germany;
authors.forename: Jutta
authors.initials: J
authors.lastname: Gampe
authors.affiliation: Department of Biology, Pomona College, Claremont, CA 91711; jwv@demogr.mpg.de dem04747@pomona.edu.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Martínez
authors.affiliation: Max Planck Institute for Demographic Research, 18057 Rostock, Germany; Max-Planck Odense Center on the Biodemography of Aging, DK-5000 Odense, Denmark; Duke Population Research Institute, Duke University, Durham, NC 27708 jwv@demogr.mpg.de dem04747@pomona.edu.
authors.forename: James W
authors.initials: JW
authors.lastname: Vaupel
mesh_terms: D000818:Animals; D005075:Biological Evolution; D005298:Fertility; D006829:Hydra / Q000502:physiology*; D008017:Life Expectancy
keywords: aging; biodemography; clonal reproduction; invertebrates; nonsenescence