title: Antiulcer properties of Glycyrrhiza glabra L. extract on experimental models of gastric ulcer in mice.
abstract: Glycyrrhiza glabra L. is used in folk medicine for treatment of stomach disorders including peptic ulcers. The hydroalcoholic extract of Glycyrrhiza glabra L. (HEGG) was evaluated for antiulcerogenic activity and acute toxicity profile in mice. Various doses of HEGG (50-200 mg/kg) were administered orally to animals of different groups. Omeprazole and cimetidine at doses of 30 and 100 mg/kg were used as positive controls, respectively. Stomach was opened along the greater curvature then ulceration index was determined examining the inner lining of stomach. Oral administration of the extract at 1600 mg/kg did not produce toxic symptoms and mortality in mice. 2950 mg/kg was determined as the oral LD50. The HEGG (50-200 mg/kg) showed a significant reduction in ulcer index in HCl/Ethanol-induced ulcer. G. glabra extract (50-150 mg/kg) showed antiulcer activity against indomethacin-induced gastric lesions dose dependently. The extract effectively inhibited formation of gastric lesions induced by ethanol. The extract (200 mg/kg) was more potent than omeprazole (30 mg/kg). HEGG reduced the ulcer index in hypothermic stress induced gastric ulcers in mice and the antiulcer effect was comparable to that of cimetidine. The results indicated that G. glabra hydroalcoholic extract exerted an antiulcergenic effect that could be associated with increase in gastric mucosal defensive factors.
authors.affiliation: Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
authors.forename: Ghader
authors.initials: G
authors.lastname: Jalilzadeh-Amin
authors.affiliation: Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Najarnezhad
authors.affiliation: Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Anassori
authors.affiliation: Graduated, School of Veterinary Medicine, Urmia University, Urmia, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Mostafavi
authors.affiliation: DVM student, School of Veterinary Medicine, Urmia University, Urmia, Iran.
authors.forename: Hadi
authors.initials: H
authors.lastname: Keshipour
keywords: Ethanol; Glycyrrhiza glabra L; Indomethacin; Peptic Ulcer; Stress