title: Low baseline serum albumin as a predictor of anemia in chronic hemodialysis patients.
abstract: BACKGROUND
  Inflammatory process has a substantial contribution in the development of anemia in chronic hemodialysis patients. Low serum albumin in hemodialysis patients is considered a marker of inflammation. The present longitudinal study aimed to determine the relationship between low baseline serum albumin and future development of anemia.
  
  
  METHODS
  The population of this study consisted of all patients on standard maintenance hemodialysis for at least three months or longer. Patients were classified as high or low serum albumin level (≥ or < 3.9 gr/dl). All patients received the standard treatment of anemia. The main objective of this study was to compare the prevalence of anemia defined as hemoglobin levels < 11 gr/dl between the two study groups at the end of the study period.
  
  
  RESULTS
  A total of 82 patients (50% females) with mean±SD age of 55±16.8 years and mean dialysis duration of 5.2±4 years were followed-up for an average period of 10±1 (range, 8-11) months, however 48 patients with high serum albumin and 24 patients with low serum albumin group completed the study. At baseline, the two groups were similar regarding hemoglobin (9.8±1.2 vs 9.16±1.6 gr/dl, P=0.95) levels. At endpoint, prevalence of anemia in high albumin group was significantly lower than the low albumin group (50% versus 83.3% P=0.005).
  
  
  CONCLUSIONS
  The findings of this study indicate that low serum albumin in hemodialysis patients is a predictor of anemia indicating unresponsiveness to conventional treatment of anemia.
authors.affiliation: Department of Internal Medicine, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Heidari
authors.affiliation: Department of Internal Medicine, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Taheri
authors.affiliation: Department of Social Medicine, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Karimollah
authors.initials: K
authors.lastname: Hajian-Tilaki
authors.affiliation: Department of Internal Medicine, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Yolmeh
authors.affiliation: Department of Internal Medicine, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Roghayeh
authors.initials: R
authors.lastname: Akbari
keywords: Anemia; Hemodialysis; Serum Albumin