title: [Behavioral phenotypes of autism spectrum disorder patients and their parents].
abstract: OBJECTIVE
  To explore the relationship between the behavior phenotypes of patients with autism spectrum disorder (ASD) and their parents through family study.
  
  
  METHODS
  Forty-five core families with ASD and 30 control families from Chengdu area were examined using Autism Spectrum Quotient (AQ). Descriptive statistical analysis, correlation analysis, and Logistic regression analysis were used to investigate the effect of various factors, especially genetic factors that may affect the pathogenesis of ASD.
  
  
  RESULTS
  The social skills factor and communication factor of the father's AQ scale, as well as the mother's age of childbearing and AQ social skills factor are related to whether children with ASD (R were 0.46, 0.39, 0.39 and 0.36, P<0.05). The communication factor of the parents' AQ and mother's attention to detail factor are related to whether children will show developmental anomaly before the age of 36 months (R were 0.55, 0.51 and 0.54, P<0.05). The social skill problems of parents and father's communication problems are risk factors for children with autism.
  
  
  CONCLUSIONS
  ASD may be influenced by both genetic and environmental factors. The autistic behavior phenotype of parents is a risk factor for ASD and is associated with developmental anomalies of early childhood.
authors.affiliation: Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China. huangyi0412@126.com.
authors.forename: Mingjing
authors.initials: M
authors.lastname: Situ
authors.forename: Xiao
authors.initials: X
authors.lastname: Hu
authors.forename: Jia
authors.initials: J
authors.lastname: Cai
authors.forename: Kuifang
authors.initials: K
authors.lastname: Guo
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000328:Adult; D000067877:Autism Spectrum Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology*; D002648:Child; D002652:Child Behavior / Q000523:psychology*; D002675:Child, Preschool; D003142:Communication; D005260:Female; D006801:Humans; D007223:Infant; D007407:Interviews as Topic; D016015:Logistic Models; D008297:Male; D010290:Parents / Q000523:psychology*; D010641:Phenotype; D012919:Social Behavior; D011795:Surveys and Questionnaires