title: [Confirmation of an excess of cancer mortality in a cohort of workers of a chromium thin-layer plating].
abstract: OBJECTIVE
  to extend up to year 2013 the follow-up for mortality of a cohort of workers in a chromium and nickel plating plant, where an excess of lung cancers was already identified.
  
  
  METHODS
  10 years after the first study about cancer mortality in a cohort of workers involved in the chromium thin-layer plating, published in 2006, we updated the evaluation of themortality of a cohort ofworkers employed in the same chromiumthin-layer plating factory with at least 6 months of work between 1968 and 1994.The mortality rates are compared with those of the Italian and Veneto Region (Northern Italy) populations.The dose-response relationship between work duration and lung cancer is assessed by adjusted Poisson regression.
  
  
  METHODS
  127 unskilled or skilled workers involved in the production process.
  
  
  RESULTS
  in the updated follow-up, 35 deaths occurred among the subjects under study: 19 for cancer (of which 11 for lung cancer and 3 for pancreatic cancer). A marked excess ofmortality due to lung cancer is observed. In addition, the newfollowup shows a significant excess of pancreatic cancer mortality. Lung cancer mortality is positively associated with work duration and the risk increases by 13%(95%CI 1-26) for each additional year of work.
  
  
  CONCLUSIONS
  the extension of followup confirms that this cohort expresses an increased mortality from cancer deaths, due to a marked excess of lung and pancreatic cancers. The effect of smoking has only a secondary effect in the cancer onset expressed by this cohort. The risk of lung cancer increased with work duration and thus with occupational exposure to chromium and nickel.
authors.forename: Paolo
authors.initials: P
authors.lastname: Girardi
authors.forename: Vittoria
authors.initials: V
authors.lastname: Bressan
authors.forename: Tommy
authors.initials: T
authors.lastname: Mabilia
authors.forename: Enzo
authors.initials: E
authors.lastname: Merler
mesh_terms: D002273:Carcinogens; D002857:Chromium / Q000009:adverse effects*; D015331:Cohort Studies; D004595:Electroplating; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008175:Lung Neoplasms / Q000139:chemically induced / Q000401:mortality*; D008669:Metallurgy; D009669:Nose Neoplasms / Q000139:chemically induced / Q000401:mortality*; D009784:Occupational Diseases / Q000139:chemically induced / Q000401:mortality*; D016273:Occupational Exposure / Q000009:adverse effects*; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014001:Tin / Q000009:adverse effects*
chemical_list: D002273:Carcinogens; D002857:Chromium; D014001:Tin