title: Anti-diabetic Effect of Friedelan Triterpenoids in Streptozotocin Induced Diabetic Rat.
abstract: We herein report the anti-diabetic effect of the natural friedelan tritepenoid, 4-oxa-3, 4-secofriedelan (cerin), isolated from cork tissue of Quercus suber L. and its oxygenated derivative, 4-oxa-3, 4-secofriedelan-3-oic acid (cerin(ox)) in streptozotocin (STZ)-induced diabetic rat. Male Sprague Dawley rats were randomized into four groups: non-diabetic control (Group I), STZ-induced diabetic rats (Group II), STZ-induced diabetic rats treated with cerin (Group III), and STZ-induced diabetic rats treated with cerin(ox), (Group IV). Administration of cerin (3 mg/kg) and cerin(ox), (3 mg/kg) orally to STZ-diabetic rats for three weeks improved the body weight, reduced serum glucose level and activities of alkaline phosphatase, acid phosphatase, glutamate-oxaloacetate transaminase and glutamate-pyruvate transaminase, and restored liver antioxidant status.
authors.forename: Amitava
authors.initials: A
authors.lastname: Mandal
authors.forename: Vaskar
authors.initials: V
authors.lastname: Das
authors.forename: Pranab
authors.initials: P
authors.lastname: Ghosh
authors.forename: Shilpi
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D029963:Quercus / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D014315:Triterpenes / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: C439990:2-hydroxyfriedelan-3-one; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D014315:Triterpenes