title: Proliferative Constituents from the Leaves of Micromelum integerrimum.
abstract: Two new compounds, 5-O-methyl-4-desmethyl-myricanol (1) and 6-formyl-5-isopropyl-3-hydroxymethyl-7-methyl-1H-indene (2), were isolated from the leaves of Micromelum integerrimum. Their structures were determined by spectroscopic methods. Additionally, compound 1 could stimulate the growth of NIH3T3 cells and promote cell migration. Compound 1 might exert its effects through increasing the protein expression of connective tissue growth factor.
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Hu
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Sun
authors.forename: Tang-Yun
authors.initials: TY
authors.lastname: Yu
authors.forename: Jing-Cheng
authors.initials: JC
authors.lastname: Wang
authors.forename: Jin-Shan
authors.initials: JS
authors.lastname: He
authors.forename: Yue-Lai
authors.initials: YL
authors.lastname: Zhou
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Li
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D036381:Diarylheptanoids / Q000737:chemistry*; D007192:Indenes / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D018515:Plant Leaves / Q000737:chemistry*; D027821:Rutaceae / Q000737:chemistry*
chemical_list: C000604463:5-O-methyl-4-desmethyl-myricanol; C000604529:6-formyl-5-isopropyl-3-hydroxymethyl-7-methyl-1H-indene; D036381:Diarylheptanoids; D007192:Indenes