title: [Determination of thiodiglycolic acid in urine with gas chromatography-mass spectrometer].
abstract: OBJECTIVE
  To establish a rapid determination method with gas chromatography-mass spectrometer (GC-MS) for thiodiglycolic acid (TDGA), a vinyl chloride (VCM) biomarker.
  
  
  METHODS
  A high- sensitivity determination method was established using a moderate methyl esterification instead of methyl esterification of highly toxic diazo reaction.
  
  
  RESULTS
  The standard curve regression linear equation of the method was: y=8460.5x-4758.2, the linear coefficient was 0.999 7, the minimum quantity concentration was 2.0 µg/L, the range of precision value was 0.81%-2.38%, and the average recovery of standard addition was 99.0%-102.9%.
  
  
  CONCLUSIONS
  This method reduces the risk of traditional methyl esterification, improves the determination sensitivity compared with the GC-FPD method, and meets the determination requirement of TDGA.
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Xiao
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Fu
authors.forename: Chengming
authors.initials: C
authors.lastname: Meng
authors.forename: Yuelan
authors.initials: Y
authors.lastname: Xuan
authors.forename: Wenhua
authors.initials: W
authors.lastname: Qin
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D013864:Thioglycolates / Q000652:urine*; D014752:Vinyl Chloride
chemical_list: D013864:Thioglycolates; C010518:thiodiacetic acid; D014752:Vinyl Chloride