title: Maniwamycins: new quorum-sensing inhibitors against Chromobacterium violaceum CV026 were isolated from Streptomyces sp. TOHO-M025.
abstract: Quorum sensing is an important microbial signaling system that controls the expression of many virulence genes. Maniwamycins C-F, new compounds and quorum-sensing inhibitors, were isolated from the culture broth of Streptomyces sp. TOHO-M025 using a silica gel column and preparative HPLC. The structures of maniwamycins were elucidated by spectroscopic analyses, including NMR. The compounds each have an azoxy moiety. All maniwamycins inhibited violacein synthesis, which is controlled by quorum sensing, in Chromobacterium violaceum CV026.
authors.affiliation: Department of Microbiology, Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Fukumoto
authors.affiliation: Department of Microbiology, Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan.
authors.forename: Chikana
authors.initials: C
authors.lastname: Murakami
authors.affiliation: Department of Microbiology, Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan.
authors.forename: Yojiro
authors.initials: Y
authors.lastname: Anzai
authors.affiliation: Department of Microbiology, Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Kato
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001391:Azo Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D002861:Chromobacterium / Q000187:drug effects*; D007211:Indoles / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D053038:Quorum Sensing / Q000187:drug effects*; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001391:Azo Compounds; D007211:Indoles; C000614293:maniwamycin C; C000614294:maniwamycin D; C000614295:maniwamycin E; C000614296:maniwamycin F; C063155:violacein