title: Synthesis of Unsymmetrical α,α-Diarylacetates.
abstract: Ethyl bromofluoroacetate has been developed as a precursor for the convenient synthesis of unsymmetrical α,α-diarylacetates featuring indoles, anilines, and other electron-rich aromatics. In conjunction with a mild Lewis acid catalyzed C-N → C-C exchange, intermediate arylglycines can be synthesized and transformed into α,α-diarylacetates in a one-pot protocol, resulting in a net diarylation reaction exhibiting a wide scope. In the context of diarylacetates, the synthetic equivalence of the fluorinated reagent with α-nitro-α-diazo carbonyls was established.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kanpur , Kanpur-208016, India.
authors.forename: Santosh D
authors.initials: SD
authors.lastname: Jadhav
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kanpur , Kanpur-208016, India.
authors.forename: Anand
authors.initials: A
authors.lastname: Singh