title: EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques.
abstract: Alzheimer's disease (AD) is characterized by the transition of amyloid-β (Aβ) monomers into toxic oligomers and plaques. Given that Aβ abnormality typically precedes the development of clinical symptoms, an agent capable of disaggregating existing Aβ aggregates may be advantageous. Here we report that a small molecule, 4-(2-hydroxyethyl)-1-piperazinepropanesulphonic acid (EPPS), binds to Aβ aggregates and converts them into monomers. The oral administration of EPPS substantially reduces hippocampus-dependent behavioural deficits, brain Aβ oligomer and plaque deposits, glial γ-aminobutyric acid (GABA) release and brain inflammation in an Aβ-overexpressing, APP/PS1 transgenic mouse model when initiated after the development of severe AD-like phenotypes. The ability of EPPS to rescue Aβ aggregation and behavioural deficits provides strong support for the view that the accumulation of Aβ is an important mechanism underlying AD.
authors.affiliation: Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.|Biological Chemistry Program, Korea University of Science and Technology (UST), 217 Gajungro Yuseong-gu, Daegeon 305-806, Republic of Korea.|Research Institute, GoshenBiotech Inc., 78, Sure-ro 640beon-gil, Wabu-eup, Namyangju-si, Gyeonggi-do 472-905, Republic of Korea.
authors.forename: Hye Yun
authors.initials: HY
authors.lastname: Kim
authors.affiliation: Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.|Biological Chemistry Program, Korea University of Science and Technology (UST), 217 Gajungro Yuseong-gu, Daegeon 305-806, Republic of Korea.
authors.forename: Hyunjin Vincent
authors.initials: HV
authors.lastname: Kim
authors.affiliation: Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
authors.forename: Seonmi
authors.identifier: http://orcid.org/0000-0002-0305-3250
authors.initials: S
authors.lastname: Jo
authors.affiliation: Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
authors.forename: C Justin
authors.initials: CJ
authors.lastname: Lee
authors.affiliation: Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
authors.forename: Seon Young
authors.initials: SY
authors.lastname: Choi
authors.affiliation: Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
authors.forename: Dong Jin
authors.initials: DJ
authors.lastname: Kim
authors.affiliation: Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.|Biological Chemistry Program, Korea University of Science and Technology (UST), 217 Gajungro Yuseong-gu, Daegeon 305-806, Republic of Korea.
authors.forename: YoungSoo
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000523:psychology; D016564:Amyloid beta-Protein Precursor / Q000172:deficiency* / Q000235:genetics; D000818:Animals; D003071:Cognition / Q000187:drug effects; D004195:Disease Models, Animal; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008822:Mice, Transgenic; D010879:Piperazines / Q000008:administration & dosage*; D058225:Plaque, Amyloid / Q000378:metabolism*; D053764:Presenilin-1 / Q000172:deficiency* / Q000235:genetics
chemical_list: D016564:Amyloid beta-Protein Precursor; C000607446:N(2-hydroxythyl)piperazine-N'-(3-propanesulfonic acid); D010879:Piperazines; D053764:Presenilin-1