title: GLUCOMANNAN AND GLUCOMANNAN PLUS SPIRULINA-ENRICHED SQUID-SURIMI ADDED TO HIGH SATURATED DIET AFFECT GLYCEMIA, PLASMA AND ADIPOSE LEPTIN AND ADIPONECTIN LEVELS IN GROWING FA/FA RATS.
abstract: Type 2 diabetes is a very prevalent chronic disease. Among dietary factors for its prevention and treatment, interest has grown in satiating fibre (konjac glucomannan) and spirulina. Our previous studies suggest that glucomannan itself and/or in conjunction to spirulina displayed hypolipemic and antioxidant effects when incorporated to squid surimi as functional ingredients. The present study aims to determine whether glucomannan- enriched or glucomannan plus spirulina-enriched squid-surimi improve plasma glucose and insulin levels in Zucker fa/fa rats fed a high saturated fat diet. Twenty four growing rats, divided into three groups, were given modified AIN-93M diets for seven weeks: 30% squid-surimi control diet (C), 30% glucomannan-enriched squid-surimi diet (G) and 30% glucomannan plus spirulina-enriched squid-surimi diet (GS). All rats became hyperglycemics and hyperinsulinemics, but G and GS diets induced significantly lower glucose levels (20%; p < 0.05) but did not modify insulinemia with respect to C diet. GS animals showed higher HOMA-D (p < 0.05) than C ones suggesting increased insulin availability. Plasma leptin and adiponectin decreased in G and GS vs. C group (p < 0.05). Adipose adiponectin increased significantly in G and GS vs. C rats (16-20 times, p < 0.01). Leptin in adipose tissue was higher in GS vs. G group (p < 0.05). In conclusion, both glucomannan-diets were able to reduce hyperglycemia and increase adipose tissue adiponectin levels in fa/fa rats, suggesting an anti-hypertrophic and insulin-sensitizing adipokine effect in this tissue. Spirulina inclusion increased insulin availability. Although results are promising, the utility of consuming glucomannan surimis as part of usual diets demands future studies.
authors.affiliation: Departamento de Nutrición y Bromatología I (Nutrición), Facultad de Farmacia, Universidad Complutense de Madrid, Madrid.. frasan@ucm.es.
authors.forename: Miguel
authors.initials: M
authors.lastname: Vázquez-Velasco
authors.affiliation: Departamento de Nutrición y Bromatología I (Nutrición), Facultad de Farmacia, Universidad Complutense de Madrid, Madrid.. frasan@ucm.es.
authors.forename: Laura
authors.initials: L
authors.lastname: González-Torres
authors.affiliation: Centro de Análisis Sanitarios, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid.. frasan@ucm.es.
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Méndez
authors.affiliation: Departamento de Nutrición y Bromatología I (Nutrición), Facultad de Farmacia, Universidad Complutense de Madrid, Madrid.. frasan@ucm.es.
authors.forename: Sara
authors.initials: S
authors.lastname: Bastida
authors.affiliation: Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid.. frasan@ucm.es.
authors.forename: Juana
authors.initials: J
authors.lastname: Benedí
authors.affiliation: Departamento de Nutrición, Bromatología y Toxicología, Facultad de Farmacia, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.. frasan@ucm.es.
authors.forename: M José
authors.initials: MJ
authors.lastname: González-Muñoz
authors.affiliation: Departamento de Nutrición y Bromatología I (Nutrición), Facultad de Farmacia, Universidad Complutense de Madrid, Madrid.. frasan@ucm.es.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Sánchez-Muniz
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis*; D049832:Decapodiformes / Q000737:chemistry*; D004032:Diet; D055951:Functional Food; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000378:metabolism*; D008297:Male; D008351:Mannans / Q000494:pharmacology*; D051381:Rats; D011924:Rats, Zucker; D017747:Seafood; D053545:Spirulina / Q000737:chemistry*
chemical_list: D052242:Adiponectin; C499920:Adipoq protein, rat; D001067:Appetite Depressants; D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D008351:Mannans; C022901:(1-6)-alpha-glucomannan