title: Nanoscale optomechanical actuators for controlling mechanotransduction in living cells.
abstract: To control receptor tension optically at the cell surface, we developed an approach involving optomechanical actuator nanoparticles that are controlled with near-infrared light. Illumination leads to particle collapse, delivering piconewton forces to specific cell surface receptors with high spatial and temporal resolution. We demonstrate optomechanical actuation by controlling integrin-based focal adhesion formation, cell protrusion and migration, and T cell receptor activation.
authors.affiliation: Department of Chemistry, Emory University, Atlanta, Georgia, USA.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Emory University, Atlanta, Georgia, USA.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Emory University, Atlanta, Georgia, USA.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Chang
authors.affiliation: Georgia Institute of Technology, George W. Woodruff School of Mechanical Engineering, Atlanta, Georgia, USA.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Seyf
authors.affiliation: Georgia Institute of Technology, George W. Woodruff School of Mechanical Engineering, Atlanta, Georgia, USA.|Georgia Institute of Technology, School of Materials Science and Engineering, Atlanta, Georgia, USA.
authors.forename: Asegun
authors.initials: A
authors.lastname: Henry
authors.affiliation: Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Alexa L
authors.initials: AL
authors.lastname: Mattheyses
authors.affiliation: Department of Chemistry, Emory University, Atlanta, Georgia, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Yehl
authors.affiliation: Department of Chemistry, Emory University, Atlanta, Georgia, USA.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: AFM Business Unit, Bruker Nano Surfaces, Santa Barbara, California, USA.
authors.forename: Zhuangqun
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Chemistry, Emory University, Atlanta, Georgia, USA.
authors.forename: Khalid
authors.initials: K
authors.lastname: Salaita
mesh_terms: D000818:Animals; D004735:Energy Transfer; D004867:Equipment Design; D008027:Light; D040542:Mechanotransduction, Cellular; D051379:Mice; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D041681:NIH 3T3 Cells; D053758:Nanoparticles; D036103:Nanotechnology / Q000295:instrumentation*; D055096:Optical Devices; D011956:Receptors, Cell Surface / Q000502:physiology*; D013314:Stress, Mechanical
chemical_list: D011956:Receptors, Cell Surface