title: Cardiorespiratory Fitness Suppresses Age-Related Arterial Stiffening in Healthy Adults: A 2-Year Longitudinal Observational Study.
abstract: Cardiorespiratory fitness is negatively associated with arterial stiffness, although it is unclear whether it is associated with prospective arterial stiffness changes. The authors examined cardiorespiratory fitness and arterial stiffness progression in a 2-year follow-up study of 470 healthy men and women aged 26 to 69 years. Peak oxygen uptake (V˙O2peak) was measured at baseline using a graded cycle exercise test. Arterial stiffness was assessed using brachial-ankle pulse wave velocity (baPWV) at baseline and after 2 years. Two-year changes in baPWV were significantly higher in patients in the lowest V˙O2peak tertile (28.8±7.6 cm/s) compared with those in the highest V˙O2peak tertile (-1.4±7.5 cm/s) (P=.024) and were inversely correlated with V˙O2peak (r=-.112, P=.015). Stepwise multiple regression analysis revealed that age, glucose, baPWV, V˙O2peak, and sex were independent correlates of 2-year changes in baPWV, suggesting that higher cardiorespiratory fitness is associated with age-related arterial stiffening suppression.
authors.affiliation: Department of Health Promotion and Exercise, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Gando
authors.affiliation: Department of Health Promotion and Exercise, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Murakami
authors.affiliation: Department of Health Promotion and Exercise, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.|Faculty of Sport Sciences, Waseda University, Saitama, Japan.
authors.forename: Ryoko
authors.initials: R
authors.lastname: Kawakami
authors.affiliation: Department of Health Promotion and Exercise, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.|Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Department of Health Promotion and Exercise, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.|Faculty of Letters, Kokushikan University, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawano
authors.affiliation: Department of Health Promotion and Exercise, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.|Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Tanaka
authors.affiliation: Department of Health Promotion and Exercise, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.
authors.forename: Susumu S
authors.initials: SS
authors.lastname: Sawada
authors.affiliation: Department of Hygiene, Faculty of Medicine, Kagawa University, Miki, Kagawa, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Miyatake
authors.affiliation: Department of Health Promotion and Exercise, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.
authors.forename: Motohiko
authors.initials: M
authors.lastname: Miyachi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D055109:Ankle Brachial Index; D001794:Blood Pressure / Q000502:physiology*; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D000072599:Cardiorespiratory Fitness / Q000502:physiology*; D018450:Disease Progression; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D064368:Healthy Volunteers; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D012307:Risk Factors; D013997:Time Factors; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult