title: Oncologic results of laparoscopic liver resection for malignant liver tumors.
abstract: BACKGROUND
  There are scant data regarding oncologic outcomes of laparoscopic liver resection (LLR). The aim of this study is to analyze the oncologic outcomes of LLR for malignant liver tumors (MLT).
  
  
  METHODS
  This was a prospective IRB-approved study of 123 patients with MLT undergoing LLR. Kaplan-Meier disease-free (DFS) and overall survival (OS) was calculated.
  
  
  RESULTS
  Tumor type was colorectal in 61%, hepatocellular cancer in 21%, neuroendocrine in 5% and others in 13%. Mean tumor size was 3.2 ± 1.9 cm and number of tumors 1.6 ± 1.2. A wedge resection or segmentectomy was performed in 63.4%, bisegmentectomy in 24.4%, and hemihepatectomy in 12.2%. Procedures were totally laparoscopic in 67% and hand-assisted in 33%. Operative time was 235.2 ± 94.3 min, and conversion rate 7.3%. An R0 resection was achieved in 90% of patients and 94% of tumors. Median hospital stay was 3 days. Morbidity was 22% and mortality 0.8%. For patients with colorectal liver metastasis, DFS and OS at 2 years was 47% and 88%, respectively.
  
  
  CONCLUSIONS
  This study shows that LLR is a safe and efficacious treatment for selected patients with MLT. Complete resection and margin recurrence rate are comparable to open series in the literature.
authors.affiliation: Department of General Surgery, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Muhammet
authors.initials: M
authors.lastname: Akyuz
authors.affiliation: Department of General Surgery, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Pinar
authors.initials: P
authors.lastname: Yazici
authors.affiliation: Department of General Surgery, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Hakan
authors.initials: H
authors.lastname: Yigitbas
authors.affiliation: Department of General Surgery, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Cem
authors.initials: C
authors.lastname: Dural
authors.affiliation: Department of General Surgery, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Alexis
authors.initials: A
authors.lastname: Okoh
authors.affiliation: Department of General Surgery, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Shamil
authors.initials: S
authors.lastname: Aliyev
authors.affiliation: Department of General Surgery, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Federico
authors.initials: F
authors.lastname: Aucejo
authors.affiliation: Department of General Surgery, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Quintini
authors.affiliation: Department of General Surgery, Cleveland Clinic, Cleveland, Ohio.
authors.forename: John
authors.initials: J
authors.lastname: Fung
authors.affiliation: Department of General Surgery, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Eren
authors.initials: E
authors.lastname: Berber
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality* / Q000601:surgery*; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000473:pathology / Q000601:surgery; D005260:Female; D006498:Hepatectomy / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D053208:Kaplan-Meier Estimate; D010535:Laparoscopy; D007902:Length of Stay; D008113:Liver Neoplasms / Q000401:mortality* / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000401:mortality / Q000601:surgery; D061646:Operative Time; D011446:Prospective Studies; D016896:Treatment Outcome
keywords: colorectal cancer; hepatocellular cancer; laparoscopic liver resection; liver cancer