title: A meta-analysis of interaction between Epstein-Barr virus and HLA-DRB1*1501 on risk of multiple sclerosis.
abstract: Infection with Epstein-Barr virus (EBV) and HLA-DRB1*1501-positivity is a risk factor for multiple sclerosis (MS), but whether an interaction between these two factors causes MS is unclear. We therefore conducted a meta-analysis on the effect of the interaction between HLA-DRB1*1501 and EBV infection on MS. Searches of PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and the Wanfan databases through February 2015 yielded 5 studies that met the criteria for inclusion in the meta-analysis. EBV infection and HLA-DRB1*1501-positivity were dichotomized. The additive (S) and multiplicative interaction indexes (OR) between EBV infection and HLA-DRB1*1501 and their 95% confidence intervals (95%CI) were calculated for each study and then combined in a meta-analysis. EBV infection was significantly associated with MS (OR = 2.60; 95%CI, 1.48-4.59). HLA-DRB1*1501 was associated with a significantly increased risk of MS (OR, 3.06; 95%CI, 2.30-4.08). An interaction effect between EBV infection and HLA-DRB1*1501 on MS was observed on the additive scale (S, 1.43; 95%CI, 1.05-1.95, P = 0.023), but no interaction effect was observed on the multiplicative scale (OR, 0.86, 95%CI, 0.59-1.26). This meta-analysis provides strong evidence that EBV alone, HLA-DRB1*1501 alone or their interaction is associated with an elevated risks of MS.
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
authors.forename: Di
authors.initials: D
authors.lastname: Xiao
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
authors.forename: Xingguang
authors.initials: X
authors.lastname: Ye
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
authors.forename: Meiling
authors.initials: M
authors.lastname: Ou
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
authors.forename: Congcong
authors.initials: C
authors.lastname: Guo
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
authors.forename: Baohuan
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.
authors.forename: Man
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Parasitology, School of Medicine, Jinan University, No.601, Huangpu Avenue West, Guangzhou, Guangdong, China.|Key Laboratory of environmental exposure and health in Guangzhou, Jinan University, Guangzhou, Guangdong, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, China.|Key Laboratory of environmental exposure and health in Guangzhou, Jinan University, Guangzhou, Guangdong, China.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Jing
mesh_terms: D020031:Epstein-Barr Virus Infections / Q000235:genetics / Q000276:immunology* / Q000821:virology; D059811:HLA-DRB1 Chains / Q000235:genetics / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000276:immunology* / Q000502:physiology; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology* / Q000821:virology; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
chemical_list: D059811:HLA-DRB1 Chains; C489631:HLA-DRB1*15:01 antigen