title: Progress in digestive endoscopy: Flexible Spectral Imaging Colour Enhancement (FICE)-technical review.
abstract: Background. A substantial advance in digestive endoscopy that has been made during the last decade is represented by digital chromoendoscopy, which was developed as a quicker and sometimes better alternative to the gold standard of dye spraying. Fujifilm developed a virtual coloration technique called Flexible spectral Imaging Color Enhancement (FICE). FICE provides a better detection of lesions of "minimal" esophagitis, of dysplasia in Barrett's esophagus and of squamous cell esophageal cancer. The use of FICE resulted in an improvement in the visualization of the early gastric cancer, being less invasive, and time consuming than the classic dye methods. Current evidence does not support FICE for screening purposes in colon cancer but it definitely improves characterization of colonic lesions. Its use in inflammatory bowel disease is still controversial and in video capsule endoscopy is considered a substantial progress. Conclusions. The use of FICE endoscopy in routine clinical practice can increase the diagnostic yield and can provide a better characterization of lesions. Future studies to validate its use, the good choice of channels, and the "perfect indications" and to provide common definitions and classifications are necessary.
authors.affiliation: Internal Medicine II-Gastroenterology, University Emergency Hospital; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: L
authors.initials: L
authors.lastname: Negreanu
authors.affiliation: Gastroenterology Department, Fundeni Clinical Institute; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: C M
authors.initials: CM
authors.lastname: Preda
authors.affiliation: Internal Medicine Department, Monza Hospital; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: D
authors.initials: D
authors.lastname: Ionescu
authors.affiliation: Physiology Department; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: D
authors.initials: D
authors.lastname: Ferechide
mesh_terms: D053704:Capsule Endoscopy; D003116:Color; D055088:Early Detection of Cancer; D016099:Endoscopy, Gastrointestinal / Q000379:methods* / Q000639:trends*; D005767:Gastrointestinal Diseases / Q000601:surgery; D006801:Humans; D007089:Image Enhancement; D012984:Software
keywords: Barrett’s esophagus; FICE; adenoma detection; chromoendoscopy; minimal esophagitis