title: Herbal medicine Davaie Loban in mild to moderate Alzheimer's disease: A 12-week randomized double-blind placebo-controlled clinical trial.
abstract: OBJECTIVE
  In traditional texts on herbal medicines, various medicinal plants have been noted to have beneficial effects on dementia and Alzheimer's disease. According to the traditional books Herbal medicine Davaie Loban (DL) has beneficial effects in Alzheimer's disease. The study aim was to determine the clinical efficacy of DL in patients with mild-to-moderate Alzheimer's disease.
  
  
  METHODS
  Double blind randomized clinical trial.
  
  
  METHODS
  Shahid Beheshti University of Medical Sciences.
  
  
  METHODS
  This included patients older than 50 years with mild to moderate Alzheimer's disease according to ADAS-cog (Alzheimer's Disease Assessment Scale-cognitive subscale; ADAS≥12) and the Clinical Dementia Rating Scale Sum of Boxes (CDR-SOB; CDR≤2). Twenty-four patients completed the study in DL group and 20 in placebo group.
  
  
  METHODS
  ADAS-cog and CDR-SOB were filled out for patients to define the improvement in memory over the study period.
  
  
  RESULTS
  At 4 weeks and 12 weeks there was significant difference in mean (SEM) ADAS-cog scores between DL and placebo groups and it was lower in DL group (p<0.001). At baseline, no significant difference was seen regarding mean (SEM) scores of CDR-SOB between DL and placebo groups (p=0.096). However, at 4 and 12 weeks there was significant difference in mean (SE) CDR-SOB scores between DL and placebo groups and it was lower in DL group (p<0.001).
  
  
  CONCLUSIONS
  Our findings suggest that DL may be effective in improvement of memory in patients with mild-to-moderate Alzheimer's disease.
authors.affiliation: Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Traditional Medicine, School of Traditional Medicine, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Haleh
authors.initials: H
authors.lastname: Tajadini
authors.affiliation: Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Rostam
authors.initials: R
authors.lastname: Saifadini
authors.affiliation: Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: rchoopani@sbmu.ac.ir.
authors.forename: Rasool
authors.initials: R
authors.lastname: Choopani
authors.affiliation: Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Mitra
authors.initials: M
authors.lastname: Mehrabani
authors.affiliation: School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kamalinejad
authors.affiliation: Research Center for Modeling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Haghdoost
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D029001:Herbal Medicine / Q000379:methods*; D006801:Humans; D008297:Male; D008519:Medicine, Traditional; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*
chemical_list: D010936:Plant Extracts
keywords: Alzheimer’s disease; Clinical trial; Davaie Loban