title: Two cases of cutaneous leishmaniasis in Dutch military personnel treated with oral miltefosine.
abstract: BACKGROUND
  In the Netherlands, cutaneous leishmaniasis is most commonly seen in military personnel deployed on a mission or training abroad. The treatment of two Dutch soldiers who acquired cutaneous leishmaniasis with oral miltefosine was evaluated. Adverse effects were monitored and the improvement of skin lesions was assessed.
  
  
  METHODS
  A military nurse with a painless Chiclero's ulcer due to Leishmania (Viannia) braziliensis acquired in Belize and a military physical training instructor with itchy swelling and small ulcer of the back of his left elbow due to L. donovani/infantum complex acquired in Ibiza were treated with oral miltefosine 50 mg three times a day for 28 days.
  
  
  CONCLUSIONS
  Both patients responded well to oral miltefosine. Adverse effects were mild. Increase of creatinine levels was seen while liver transaminase levels were unremarkable.
  
  
  CONCLUSIONS
  Miltefosine proved to be a convenient, effective and well-tolerated treatment option in the treatment of cutaneous leishmaniasis in Dutch military personnel.
authors.affiliation: Department of Dermatology, Central Military Hospital, Utrecht, The Netherlands.
authors.forename: Eric Martin
authors.initials: EM
authors.lastname: van der Snoek
authors.affiliation: Department of Dermatology, Central Military Hospital, Utrecht, The Netherlands.
authors.forename: S M
authors.initials: SM
authors.lastname: Couwenberg
authors.affiliation: Center for Tropical and Travel Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Stijnis
authors.affiliation: Laboratory for Infectious Diseases and Perinatal Screening, RIVM, Bilthoven, The Netherlands.
authors.forename: L M
authors.initials: LM
authors.lastname: Kortbeek
authors.affiliation: Department of Internal Medicine, Central Military Hospital, Utrecht, The Netherlands.
authors.forename: E M
authors.initials: EM
authors.lastname: Schadd
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008889:Military Personnel; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine
keywords: TROPICAL MEDICINE