title: Two new benzolactones from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activities.
abstract: Two new benzolactones, 5-methyl-6-prenyl-isobenzofuran-1(3H)-one (1), 5-hydroxymethyl-6-prenyl-isobenzofuran-1(3H)-one (2), together with four known phenolic compounds (3-6), were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-6 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compounds 1-6 exhibited high anti-TMV activities with inhibition rates in the range of 16.9-26.2%, respectively.
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors.forename: Qinpeng
authors.initials: Q
authors.lastname: Shen
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.|b School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Nature Products , Kunming Medical University , Kunming , P.R. China.
authors.forename: Xingmeng
authors.initials: X
authors.lastname: Xu
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors.forename: Fengmei
authors.initials: F
authors.lastname: Zhang
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors.forename: Nengjun
authors.initials: N
authors.lastname: Xiang
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors.forename: Pei
authors.initials: P
authors.lastname: He
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors.forename: Xiaoxi
authors.initials: X
authors.lastname: Si
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors.forename: Ruizhi
authors.initials: R
authors.lastname: Zhu
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors.forename: Kunmiao
authors.initials: K
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Liu
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors.forename: Chunbo
authors.initials: C
authors.lastname: Liu
authors.affiliation: a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Miao
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D014026:Nicotiana / Q000737:chemistry*; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D001572:Benzofurans; D007783:Lactones
keywords: Nicotiana tabacum; anti-tobacco mosaic virus activities; benzolactones