title: Preventing pediatric cardiomyopathy: a 2015 outlook.
abstract: Cardiomyopathies in children encompass a broad range of diseases, both genetic and acquired, which manifest as a primary cardiac disorder or as a cardiomyopathy secondary to systemic disease. The burden of this group of disorders is substantial, and growing on a global scale. The availability of disease altering treatments is limited, and therefore a focused review on the prevention of cardiomyopathies is justified. In this review, we address the prevention of cardiomyopathy in children by dealing with the root causes of disease at a molecular, clinical and population level. Recent years have yielded promising returns in basic research related to gene-targeted therapy, specific anti-viral therapies and modification of the effects of cardiotoxic drugs. Much work remains to be done in the fields of vaccine development, public health and adoption of available treatments. Effective research in this field will require that diagnostic methods are both refined, and made available more broadly, from imaging to gene testing. Much of our knowledge today is derived from the use of registries, which have successfully catalogued the detailed phenotype of affected patients, and provided long-term longitudinal follow up of affected individuals.
authors.affiliation: a Pediatric Cardiology , Stollery Children's Hospital , Edmonton , Alberta , Canada.
authors.forename: Paul F
authors.initials: PF
authors.lastname: Kantor
authors.affiliation: b Pediatric Cardiology , Children's Hospital Colorado , Denver , CO , USA.
authors.forename: Jake A
authors.initials: JA
authors.lastname: Kleinman
authors.affiliation: c Pediatric Cardiology , Cincinnati Children's Hospital Medical Center , Cincinnati , OH , USA.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Ryan
authors.affiliation: c Pediatric Cardiology , Cincinnati Children's Hospital Medical Center , Cincinnati , OH , USA.
authors.forename: Ivan
authors.initials: I
authors.lastname: Wilmot
authors.affiliation: d Pediatric Cardiology , Morgan Stanley Children's Hospital , New York , NY , USA.
authors.forename: Warren A
authors.initials: WA
authors.lastname: Zuckerman
authors.affiliation: d Pediatric Cardiology , Morgan Stanley Children's Hospital , New York , NY , USA.
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Addonizio
authors.affiliation: b Pediatric Cardiology , Children's Hospital Colorado , Denver , CO , USA.
authors.forename: Melanie D
authors.initials: MD
authors.lastname: Everitt
authors.affiliation: c Pediatric Cardiology , Cincinnati Children's Hospital Medical Center , Cincinnati , OH , USA.
authors.forename: John L
authors.initials: JL
authors.lastname: Jefferies
authors.affiliation: d Pediatric Cardiology , Morgan Stanley Children's Hospital , New York , NY , USA.
authors.forename: Teresa M
authors.initials: TM
authors.lastname: Lee
authors.affiliation: e Pediatric Cardiology , St. Jude Children's Research Hospital and Le Bonheur Children's Hospital , Memphis , TN , USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Towbin
authors.affiliation: f Department of Pediatrics , Division of Pediatric Cardiology, Wayne State University School of Medicine and Children's Hospital of Michigan , Detroit , MI , USA.
authors.forename: James D
authors.initials: JD
authors.lastname: Wilkinson
authors.affiliation: f Department of Pediatrics , Division of Pediatric Cardiology, Wayne State University School of Medicine and Children's Hospital of Michigan , Detroit , MI , USA.
authors.forename: Steven E
authors.initials: SE
authors.lastname: Lipshultz
mesh_terms: D009202:Cardiomyopathies / Q000517:prevention & control*; D002648:Child; D006331:Heart Diseases / Q000517:prevention & control*; D006801:Humans; D010372:Pediatrics; D012042:Registries
keywords: Cardiomyopathy; Cardiotoxicity; Genetics; Myocarditis; Pediatric