title: Misaligned feeding impairs memories.
abstract: Robust sleep/wake rhythms are important for health and cognitive function. Unfortunately, many people are living in an environment where their circadian system is challenged by inappropriate meal- or work-times. Here we scheduled food access to the sleep time and examined the impact on learning and memory in mice. Under these conditions, we demonstrate that the molecular clock in the master pacemaker, the suprachiasmatic nucleus (SCN), is unaltered while the molecular clock in the hippocampus is synchronized by the timing of food availability. This chronic circadian misalignment causes reduced hippocampal long term potentiation and total CREB expression. Importantly this mis-timed feeding resulted in dramatic deficits in hippocampal-dependent learning and memory. Our findings suggest that the timing of meals have far-reaching effects on hippocampal physiology and learned behaviour.
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.|UCLA Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, United States.
authors.forename: Dawn H
authors.identifier: http://orcid.org/0000-0001-7876-5757
authors.initials: DH
authors.lastname: Loh
authors.affiliation: UCLA Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, United States.|Molecular, Cellular, and Integrative Physiology PhD Program, University of California, Los Angeles, Los Angeles, United States.
authors.forename: Shekib A
authors.initials: SA
authors.lastname: Jami
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
authors.forename: Richard E
authors.initials: RE
authors.lastname: Flores
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
authors.forename: Danny
authors.initials: D
authors.lastname: Truong
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.|Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
authors.forename: Cristina A
authors.identifier: http://orcid.org/0000-0002-9867-6185
authors.initials: CA
authors.lastname: Ghiani
authors.affiliation: UCLA Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, United States.|Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: O'Dell
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.|UCLA Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, United States.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Colwell
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D005247:Feeding Behavior; D005248:Feeding Methods; D006624:Hippocampus / Q000502:physiology; D008568:Memory; D051379:Mice; D013493:Suprachiasmatic Nucleus / Q000502:physiology
keywords: CREB; circadian rhythms; hippocampus; learning and memory; mouse; neuroscience