title: Long-term neural and physiological phenotyping of a single human.
abstract: Psychiatric disorders are characterized by major fluctuations in psychological function over the course of weeks and months, but the dynamic characteristics of brain function over this timescale in healthy individuals are unknown. Here, as a proof of concept to address this question, we present the MyConnectome project. An intensive phenome-wide assessment of a single human was performed over a period of 18 months, including functional and structural brain connectivity using magnetic resonance imaging, psychological function and physical health, gene expression and metabolomics. A reproducible analysis workflow is provided, along with open access to the data and an online browser for results. We demonstrate dynamic changes in brain connectivity over the timescales of days to months, and relations between brain connectivity, gene expression and metabolites. This resource can serve as a testbed to study the joint dynamics of human brain and metabolic function over time, an approach that is critical for the development of precision medicine strategies for brain disorders.
authors.affiliation: Department of Psychology, University of Texas, Austin, Texas 78712, USA.|Department of Neuroscience, University of Texas, Austin, Texas 78712, USA.|Imaging Research Center, University of Texas, Austin, Texas 78712, USA.|Department of Psychology, Stanford University, Stanford, California 94305, USA.
authors.forename: Russell A
authors.identifier: http://orcid.org/0000-0001-6755-0259
authors.initials: RA
authors.lastname: Poldrack
authors.affiliation: Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
authors.forename: Timothy O
authors.initials: TO
authors.lastname: Laumann
authors.affiliation: Department of Psychology, Stanford University, Stanford, California 94305, USA.
authors.forename: Oluwasanmi
authors.initials: O
authors.lastname: Koyejo
authors.affiliation: Imaging Research Center, University of Texas, Austin, Texas 78712, USA.
authors.forename: Brenda
authors.initials: B
authors.lastname: Gregory
authors.affiliation: Imaging Research Center, University of Texas, Austin, Texas 78712, USA.
authors.forename: Ashleigh
authors.initials: A
authors.lastname: Hover
authors.affiliation: Department of Psychology, University of Texas, Austin, Texas 78712, USA.
authors.forename: Mei-Yen
authors.initials: MY
authors.lastname: Chen
authors.affiliation: Department of Psychology, Stanford University, Stanford, California 94305, USA.
authors.forename: Krzysztof J
authors.identifier: http://orcid.org/0000-0003-3321-7583
authors.initials: KJ
authors.lastname: Gorgolewski
authors.affiliation: Department of Neuroscience, University of Texas, Austin, Texas 78712, USA.|Imaging Research Center, University of Texas, Austin, Texas 78712, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Luci
authors.affiliation: Department of Psychology, University of Texas, Austin, Texas 78712, USA.
authors.forename: Sung Jun
authors.initials: SJ
authors.lastname: Joo
authors.affiliation: Department of Psychology, University of Texas, Austin, Texas 78712, USA.
authors.forename: Ryan L
authors.initials: RL
authors.lastname: Boyd
authors.affiliation: Genome Sequencing and Analysis Facility, University of Texas, Austin, Texas 78712, USA.
authors.forename: Scott
authors.identifier: http://orcid.org/0000-0002-3501-8388
authors.initials: S
authors.lastname: Hunicke-Smith
authors.affiliation: Center for Systems and Synthetic Biology, University of Texas, Austin, Texas 78712, USA.
authors.forename: Zack Booth
authors.initials: ZB
authors.lastname: Simpson
authors.affiliation: University Medical Center Brackenridge, Austin, Texas 78701, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Caven
authors.affiliation: Biomedical Informatics Program, Stanford University, Stanford, California 94305, USA.
authors.forename: Vanessa
authors.identifier: http://orcid.org/0000-0002-4387-3819
authors.initials: V
authors.lastname: Sochat
authors.affiliation: Department of Psychology, Stanford University, Stanford, California 94305, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Shine
authors.affiliation: Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
authors.forename: Evan
authors.initials: E
authors.lastname: Gordon
authors.affiliation: Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
authors.forename: Abraham Z
authors.initials: AZ
authors.lastname: Snyder
authors.affiliation: Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
authors.forename: Babatunde
authors.initials: B
authors.lastname: Adeyemo
authors.affiliation: Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
authors.forename: Steven E
authors.initials: SE
authors.lastname: Petersen
authors.affiliation: Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut 06114, USA.|Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Glahn
authors.affiliation: Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut 06114, USA.|Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA.
authors.forename: D
authors.initials: D
authors.lastname: Reese Mckay
authors.affiliation: South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, Texas 78520, USA.
authors.forename: Joanne E
authors.initials: JE
authors.lastname: Curran
authors.affiliation: Texas Biomedical Research Institute, San Antonio, Texas 78227, USA.
authors.forename: Harald H H
authors.initials: HH
authors.lastname: Göring
authors.affiliation: Texas Biomedical Research Institute, San Antonio, Texas 78227, USA.
authors.forename: Melanie A
authors.initials: MA
authors.lastname: Carless
authors.affiliation: South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, Texas 78520, USA.
authors.forename: John
authors.initials: J
authors.lastname: Blangero
authors.affiliation: Center for Neurobiological Imaging, Stanford University, Stanford, California 94305, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Dougherty
authors.affiliation: Image Sciences Institute, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.
authors.forename: Alexander
authors.initials: A
authors.lastname: Leemans
authors.affiliation: National Institute of Mental Health (NIMH), Bethesda, Maryland 20892, USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Handwerker
authors.affiliation: Imaging Research Center, University of Texas, Austin, Texas 78712, USA.
authors.forename: Laurie
authors.initials: L
authors.lastname: Frick
authors.affiliation: Center for Systems and Synthetic Biology, University of Texas, Austin, Texas 78712, USA.|Department of Molecular Biosciences, University of Texas, Austin, Texas 78712, USA.
authors.forename: Edward M
authors.initials: EM
authors.lastname: Marcotte
authors.affiliation: Department of Psychology, University of Texas, Austin, Texas 78712, USA.
authors.forename: Jeanette A
authors.initials: JA
authors.lastname: Mumford
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D005500:Follow-Up Studies; D015870:Gene Expression; D053263:Gene Regulatory Networks; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways; D010641:Phenotype; D011859:Radiography