title: Microsporols A-C from the Plant Endophytic Fungus Pestalotiopsis microspore.
abstract: Three new ambuic acid derivatives, microsporols A-C (1-3) and the known compound ambuic acid (4), were isolated from the solid-substrate fermentation cultures of the plant endophytic fungus Pestalotiopsis microspora. Their structures were elucidated primarily by NMR experiments. The absolute configurations of the 6,7-diol moiety in 1 and 2 were assigned using the Snatzke's method, whereas that of 3 was deduced by circular dichroism (CD) exciton chirality method. Compounds 1, 3, and 4 showed moderate 5-lipoxygenase (5-LOX) inhibitory effects.
authors.forename: Xianfu
authors.initials: X
authors.lastname: Wu
authors.forename: Yadan
authors.initials: Y
authors.lastname: Wang
authors.forename: Shuchun
authors.initials: S
authors.lastname: Liu
authors.forename: Xinzhong
authors.initials: X
authors.lastname: Liu
authors.forename: Liangdong
authors.initials: L
authors.lastname: Guo
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D003512:Cyclohexanones / Q000737:chemistry / Q000302:isolation & purification*; D060026:Endophytes / Q000737:chemistry*; D015394:Molecular Structure; D013172:Spores, Fungal / Q000737:chemistry*
chemical_list: D003512:Cyclohexanones; C000604493:microsporol A; C000604494:microsporol B; C000604460:microsporol C