title: The clinical efficacy of Diphoterine® in the management of cutaneous chemical burns: a 2-year evaluation study.
abstract: Diphoterine(®) is an amphoteric irrigating agent for the treatment of chemical burns and rapidly neutralises both acids and alkalis faster than water alone. Diphoterine(®) is widely used as a first aid agent in a wide range of industries globally. This is a retrospective review of the clinical use of Diphoterine(®) on chemical burns in an adult tertiary referral burn centre, often with a delay of several hours after the injury. patients admitted with chemical burns within 24 hours of the incident with an abnormal wound pH or in pain, were treated with Diphoterine(®) spray. Over a 32-month period, 1,875 burn referrals were admitted of which 131 (7%) were chemical burns. Diphoterine(®) was used in 47 patients (36%). The male to female ratio for the 131 patients was 4:1. Alkaline burns were the commonest (55%). patients who received Diphoterine(®) were significantly younger (38 vs 43 years; p=0.05) and presented earlier (0.5 vs 2.55 days; p=0.004). There was a significant change in the wound pH pre- and post-application of Diphoterine(®), compared to patients who were treated with water irrigation only, with a pH change of 1.076 vs 0.4 (p <0.05). There was no significant difference in the time to healing, the length of hospital stay, or need for surgery. in conclusion, based on our retrospective cohort, Diphoterine(®) could be a valuable tool for use in hospital settings to neutralise both alkaline and acid burns.
authors.affiliation: University hospital birmingham Foundation Trust, United kingdom.
authors.forename: S D L
authors.initials: SD
authors.lastname: Zack-Williams
authors.affiliation: The healing Foundation Centre for burns Research, United kingdom.
authors.forename: Z
authors.initials: Z
authors.lastname: Ahmad
authors.affiliation: University hospital birmingham Foundation Trust, United kingdom ; The healing Foundation Centre for burns Research, United kingdom ; University of birmingham, United kingdom.
authors.forename: N S
authors.initials: NS
authors.lastname: Moiemen
keywords: Diphoterine; amphoteric; chemical; hypertonic