title: The regulatory function of microRNA-1 in arrhythmias.
abstract: Arrhythmia, the basis of which is cardiomyocyte ion channel abnormalities, poses a serious threat to human health. A large number of studies have demonstrated that miRNA-1(miR-1) is involved in the occurrence of arrhythmia in many myocardial pathological conditions by post-transcriptionally regulating a variety of ion channels and proteins related to cardiac electrical activity. We aim at emphasizing the relationship between miR-1 and ion channels and proteins involved in the process of arrhythmia. In addition, we will pay attention to its future therapeutic prospects.
authors.affiliation: Department of Cardiology, Internal Medicine, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha 410011, Hunan, China. Liaocxhu@126.com guiyajun716@sina.com guoyuan0815@163.com xudanyan02@sina.com.
authors.forename: Caixiu
authors.initials: C
authors.lastname: Liao
authors.affiliation: Department of Cardiology, Internal Medicine, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha 410011, Hunan, China. Liaocxhu@126.com guiyajun716@sina.com guoyuan0815@163.com xudanyan02@sina.com.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Gui
authors.affiliation: Department of Cardiology, Internal Medicine, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha 410011, Hunan, China. Liaocxhu@126.com guiyajun716@sina.com guoyuan0815@163.com xudanyan02@sina.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Cardiology, Internal Medicine, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha 410011, Hunan, China. Liaocxhu@126.com guiyajun716@sina.com guoyuan0815@163.com xudanyan02@sina.com.
authors.forename: Danyan
authors.initials: D
authors.lastname: Xu
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000378:metabolism*; D001483:Base Sequence; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism; D020013:Calcium Signaling; D006329:Heart Conduction System; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism; D009200:Myocardial Contraction; D034622:RNA Interference
chemical_list: D015220:Calcium Channels; C544547:MIRN1 microRNA, human; D035683:MicroRNAs; D009124:Muscle Proteins