title: [Adverse drug reactions in the elderly: What dermatologists should know].
abstract: Pharmacotherapy in the elderly represents a challenge for dermatologists in regard to comorbidities, drug interactions, and compliance. Age-associated multimorbidity often results in polypharmacy and elevates the risk of adverse drug reactions. Crucial age-related alterations in pharmacokinetics must be considered when selecting drugs, particularly decreased total body water, altered proportion between muscle mass and adipose tissue, as well as decreased renal function. The purpose of this review is to help the reader identify relevant adverse drug reactions of often prescribed systemic dermatological pharmacons in geriatric patients and makes recommendations for their adequate application.
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig A.ö.R., Philipp-Rosenthal-Straße 23, 04103, Leipzig, Deutschland. dorothea.kratzsch@medizin.uni-leipzig.de.
authors.forename: D
authors.initials: D
authors.lastname: Kratzsch
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig A.ö.R., Philipp-Rosenthal-Straße 23, 04103, Leipzig, Deutschland.
authors.forename: J-C
authors.initials: JC
authors.lastname: Simon
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig A.ö.R., Philipp-Rosenthal-Straße 23, 04103, Leipzig, Deutschland.
authors.forename: R
authors.initials: R
authors.lastname: Treudler
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003875:Drug Eruptions / Q000175:diagnosis* / Q000517:prevention & control*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis* / Q000517:prevention & control*; D005260:Female; D015577:Geriatric Assessment / Q000379:methods*; D006801:Humans; D008297:Male; D008508:Medication Errors / Q000517:prevention & control*
keywords: Drug interactions; Geriatric dermatology; Pharmacokinetics; Pharmacotherapy; Polypharmacy