title: [COPD: An early disease].
abstract: This general review deals with the mechanisms which underlie the genetic factors in COPD. Many cellular and biochemical mechanisms occur in bronchial inflammation. We present the experimental models of COPD, insisting on the importance of oxydative stress, and on recent knowledge about the lung microbiome. Starting from this pathophysiology basis, we show how various genetic targets are able to interfere with the disease model. Thanks to these genetic targets, new markers in exhaled breath condensates and new drug targets are rising.
authors.affiliation: Service de pneumologie A, centre hospitalier de Lyon Sud, hospices civils de Lyon, faculté de médecine, université Claude-Bernard Lyon 1, 69310 Pierre-Bénite, France. Electronic address: vmargelidon@gmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Margelidon-Cozzolino
authors.affiliation: Service de cardiologie, CHU Mohammed VI, faculté de médecine et de pharmacie, université Cadi Ayyad, Marrakech, Maroc.
authors.forename: K
authors.initials: K
authors.lastname: Chbini
authors.affiliation: Service de pneumologie A, centre hospitalier de Lyon Sud, hospices civils de Lyon, 69310 Pierre-Bénite, France.
authors.forename: N
authors.initials: N
authors.lastname: Freymond
authors.affiliation: Service de pneumologie, hôpital de la Croix Rousse, hospices civils de Lyon, faculté de médecine Lyon Sud, université Claude-Bernard Lyon 1, 69005 Lyon, France.
authors.forename: G
authors.initials: G
authors.lastname: Devouassoux
authors.affiliation: Inserm 1111, faculté de médecine Lyon Sud, chemin du Grand-Revoyet, 69310 Pierre-Bénite, France.
authors.forename: A
authors.initials: A
authors.lastname: Belaaouaj
authors.affiliation: Service de pneumologie A, centre hospitalier de Lyon Sud, hospices civils de Lyon, faculté de médecine Lyon Sud, université Claude-Bernard Lyon 1, 69310 Pierre-Bénite, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Pacheco
mesh_terms: D018450:Disease Progression; D004198:Disease Susceptibility; D004777:Environment; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D008168:Lung / Q000473:pathology / Q000503:physiopathology; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000473:pathology*
keywords: BPCO; COPD; Genetic; Génétique; Micro-ARNs; MicroRNA; Microbiome; Oxydative stress; Stress oxydatif; Toll-like receptor