title: Dry eye findings worsen with anticholinergic therapy in patients with urge incontinence.
abstract: OBJECTIVE
  To evaluate the effects of oral anticholinergic (OAC) drugs on tear secretion in women with overactive bladder over a 3-month follow-up period.
  
  
  METHODS
  In this prospective study, 108 women with a diagnosis of overactive bladder were evaluated. All patients were examined ophthalmologically at baseline (day 0), and after 1 month (day 30) and 3 months (day 90) of OAC treatment. Tear film break-up time (BUT) and Schirmer 1 test results were recorded. The subjective complaints of the patients including dry mouth, and burning, dryness and foreign body sensation in the eyes, were also recorded. The chi-squared test or the paired sample t test as appropriate, was used for statistical analysis.
  
  
  RESULTS
  The mean age of the patients was 51.8 ± 9.2 years (30 - 69 years). The most frequent subjective complaints were dry mouth and dry eyes and both complaints were significant on both day 30 and day 90. Both tear film BUT and Schirmer 1 test results were significantly lower on day 30 and day 90. Dry eye measurement values worsened with prolongation of OAC treatment (p = 0.037 and p = 0.012 for BUT, and p = 0.046 and p = 0.035 for Schirmer 1 test, on day 30 and day 90, respectively).
  
  
  CONCLUSIONS
  OAC treatment in women with overactive bladder significantly and progressively affects tear secretion.
authors.affiliation: Ophthalmology Department, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. zuhaltunay@gmail.com.|Göz Hastalıkları Polikliniği, Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi, Talatpaşa Bulvarı, Altındağ, 06200, Ankara, Turkey. zuhaltunay@gmail.com.
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Ozen Tunay
authors.affiliation: Ophthalmology Department, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Ozdemir
authors.initials: O
authors.lastname: Ozdemir
authors.affiliation: Ophthalmology Department, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Damla
authors.initials: D
authors.lastname: Ergintürk Acar
authors.affiliation: Urogynecology Department, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Sabri
authors.initials: S
authors.lastname: Cavkaytar
authors.affiliation: Urogynecology Department, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Ersoy
mesh_terms: D000328:Adult; D000368:Aged; D018680:Cholinergic Antagonists / Q000009:adverse effects*; D015352:Dry Eye Syndromes / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D053202:Urinary Incontinence, Urge / Q000188:drug therapy*; D014987:Xerostomia / Q000139:chemically induced
chemical_list: D018680:Cholinergic Antagonists
keywords: Anticholinergic therapy; Dry eye; Overactive bladder