title: Release behavior of tetracycline hydrochloride loaded chitosan/poly(lactic acid) antimicrobial nanofibrous membranes.
abstract: The present work aimed to evaluate the release behavior of tetracycline hydrochloride loaded chitosan/poly(lactic acid) (Tet-CS/PLA) antimicrobial nanofibrous membranes fabricated via electrospinning technique. The electrospinning solution was a blend of Tet, CS formic acid solution and PLA chloroform/ethanol solution. The interaction between CS and PLA in CS/PLA nanofibers was confirmed to be hydrogen bond. The incorporation of Tet caused a slight decrease in the diameter of nanofibers with Tet content below 30%. Tet-CS/PLA nanofibrous membrane showed a slight initial burst within the first 4h before a gradual increase in cumulative release, and the release percentage increased with increasing Tet contents. Tet release (Mt/M∞<0.6) from the medicated nanofibers could be described by Fickian diffusion model and the release profiles showed two sequential stages. Tet-CS/PLA nanofibrous membranes exhibited an effective and sustainable inhabitance on the growth of Staphylococcus aureus, and the antimicrobial activity increased rapidly with increasing Tet contents below 20%. Furthermore, the incorporation of Tet promoted the degradation of nanofibrous membranes.
authors.affiliation: School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China.
authors.forename: Suwei
authors.initials: S
authors.lastname: Jiang
authors.affiliation: School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Lv
authors.affiliation: School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China.
authors.forename: Man
authors.initials: M
authors.lastname: Ding
authors.affiliation: School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China; Anhui Institute of Agro-Products Intensive Processing Technology, Hefei, Anhui 230009, People's Republic of China. Electronic address: hlwang@hfut.edu.cn.
authors.forename: Hualin
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China; Anhui Institute of Agro-Products Intensive Processing Technology, Hefei, Anhui 230009, People's Republic of China.
authors.forename: Shaotong
authors.initials: S
authors.lastname: Jiang
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D019344:Lactic Acid / Q000737:chemistry*; D008567:Membranes, Artificial; D057139:Nanofibers / Q000737:chemistry*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000254:growth & development*; D013752:Tetracycline / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D048271:Chitosan; D013752:Tetracycline
keywords: Chitosan/poly(lactic acid); Electrospinning technique; Nanofibrous membrane; Release; Tetracycline hydrochloride