title: A focus on inflammation as a major risk factor for atherosclerotic cardiovascular diseases.
abstract: Atherosclerosis is a dynamic, pathogenic process in the artery wall, with potential adverse outcome for the host. Acute events such as myocardial infarction and ischemic stroke often result from rupture of unstable atherosclerotic lesions. Understanding the underlying pathology of such lesions and why and when they rupture, is therefore of great interest for the development of new diagnostics and treatment. Inflammation is one of the key drivers of atherosclerotic plaque development and the interplay between inflammation and lipids constitutes the hallmark of atherosclerotic disease. This review summarizes the role of inflammation in atherosclerosis and presents some of the latest discoveries as well as unmet needs regarding the role of inflammation as major risk factor in atherosclerotic disease.
authors.affiliation: a Research Institute of Internal Medicine , Oslo University Hospital Rikshospitalet , Oslo , Norway.|b Faculty of Medicine , University of Oslo , Oslo , Norway.
authors.forename: Ida
authors.initials: I
authors.lastname: Gregersen
authors.affiliation: a Research Institute of Internal Medicine , Oslo University Hospital Rikshospitalet , Oslo , Norway.|c Hospital for Rheumatic Diseases , Lillehammer , Norway.
authors.forename: Sverre
authors.initials: S
authors.lastname: Holm
authors.affiliation: a Research Institute of Internal Medicine , Oslo University Hospital Rikshospitalet , Oslo , Norway.|b Faculty of Medicine , University of Oslo , Oslo , Norway.
authors.forename: Tuva B
authors.initials: TB
authors.lastname: Dahl
authors.affiliation: a Research Institute of Internal Medicine , Oslo University Hospital Rikshospitalet , Oslo , Norway.|b Faculty of Medicine , University of Oslo , Oslo , Norway.|d K.G. Jebsen Inflammatory Research Center , University of Oslo , Oslo , Norway.
authors.forename: Bente
authors.initials: B
authors.lastname: Halvorsen
authors.affiliation: a Research Institute of Internal Medicine , Oslo University Hospital Rikshospitalet , Oslo , Norway.|b Faculty of Medicine , University of Oslo , Oslo , Norway.|d K.G. Jebsen Inflammatory Research Center , University of Oslo , Oslo , Norway.|e Section of Clinical Immunology and Infectious Diseases , Oslo University Hospital Rikshospitalet , Oslo , Norway.
authors.forename: Pål
authors.initials: P
authors.lastname: Aukrust
mesh_terms: D050197:Atherosclerosis / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D009203:Myocardial Infarction / Q000473:pathology; D058226:Plaque, Atherosclerotic / Q000473:pathology*; D012307:Risk Factors
keywords: Atherosclerosis; T cells; cytokines; inflammation; monocytes