title: One-carbon metabolism and epigenetics: understanding the specificity.
abstract: One-carbon metabolism is a metabolic network that integrates nutrient status from the environment to yield multiple biological functions. The folate and methionine cycles generate S-adenosylmethionine (SAM), which is the universal methyl donor for methylation reactions, including histone and DNA methylation. Histone methylation is a crucial part of the epigenetic code and plays diverse roles in the establishment of chromatin states that mediate the regulation of gene expression. The activities of histone methyltransferases (HMTs) are dependent on intracellular levels of SAM, which fluctuate based on cellular nutrient availability, providing a link between cell metabolism and histone methylation. Here we discuss the biochemical properties of HMTs, their role in gene regulation, and the connection to cellular metabolism. Our emphasis is on understanding the specificity of this intriguing link.
authors.affiliation: Field of Biochemistry, Molecular, and Cell Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York.
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Mentch
authors.affiliation: Field of Biochemistry, Molecular, and Cell Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York.|Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina.|Duke Cancer Institute, Duke University Medical School, Durham, North Carolina.|Duke Molecular Physiology Institute, Duke University Medical School, Durham, North Carolina.
authors.forename: Jason W
authors.initials: JW
authors.lastname: Locasale
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D057890:Epigenomics; D005492:Folic Acid / Q000378:metabolism*; D005786:Gene Expression Regulation; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000737:chemistry / Q000378:metabolism; D006657:Histones / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D053858:Metabolic Networks and Pathways; D008715:Methionine / Q000378:metabolism*; D008745:Methylation; D012436:S-Adenosylmethionine / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D002843:Chromatin; D006657:Histones; D012436:S-Adenosylmethionine; D005492:Folic Acid; D008715:Methionine; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase
keywords: epigenetics; histone methylation; histone methyltransferase; one-carbon metabolism