title: The CRISPR revolution and its impact on cancer research.
abstract: A revolution in cancer research is underway. Spurred by the advent of the CRISPR-Cas9 technology, new methods to probe the mammalian genomes are being developed. By providing simple, flexible, and cost-effective ways to edit and manipulate the genome of somatic cells of adult animals, these new methods present the opportunity to model cancer progression in vivo with an unprecedented degree of sophistication. Here we provide a brief overview of this exciting and fast-moving field.
authors.affiliation: Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, New York.
authors.forename: Ram
authors.initials: R
authors.lastname: Kannan
authors.affiliation: Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, New York, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ventura
mesh_terms: D000818:Animals; D064113:CRISPR-Cas Systems / Q000235:genetics*; D004195:Disease Models, Animal; D018450:Disease Progression; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics*