title: Effect of combined oral contraceptive use on serum 25-hydroxy vitamin D levels and ultrasound parameters in patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate if there is an effect of combined oral contraceptive (COC) use on serum 25-hydroxy vitamin D [25(OH)D] levels in patients with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  PCOS was defined by the 2003 Rotterdam criteria. All patients with PCOS were treated with a COC containing 0.035 mg ethinylestradiol and 2 mg cyproterone acetate for 6 months. Serum 25(OH)D levels, HOMA-IR, ovarian volume and antral follicule count were measured before and after the treatment.
  
  
  RESULTS
  The median 25(OH)D levels were 9.40 (range 4.40-24.50) μg/l and 7.00 (5.00-13.50) μg/l before and after COC use, respectively. Serum 25(OH)D levels decreased after the treatment; however, the difference was not statistically significant (p = 0.055).
  
  
  CONCLUSIONS
  This study seems to be the first prospective trial revealing the effect of COC use on serum 25(OH)D levels in women with PCOS. Although the decrease in serum 25(OH)D levels in patients with PCOS with the use of COC alone, did not reach to statistically significance level after 6 months treatment with COC.
authors.affiliation: a Department of Obstetrics & Gynecology , Turgut Ozal University School of Medicine , Ankara , Turkey .
authors.forename: Müberra
authors.initials: M
authors.lastname: Namli Kalem
authors.affiliation: a Department of Obstetrics & Gynecology , Turgut Ozal University School of Medicine , Ankara , Turkey .
authors.forename: Deniz
authors.initials: D
authors.lastname: Hizli
authors.affiliation: b Department of Obstetrics and Gynecology , Erzurum Nene Hatun Hospital , Erzurum , Turkey .
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Kamalak
authors.affiliation: a Department of Obstetrics & Gynecology , Turgut Ozal University School of Medicine , Ankara , Turkey .
authors.forename: Aydin
authors.initials: A
authors.lastname: Kösüs
authors.affiliation: a Department of Obstetrics & Gynecology , Turgut Ozal University School of Medicine , Ankara , Turkey .
authors.forename: Nermin
authors.initials: N
authors.lastname: Kösüs
authors.affiliation: c Department of Obstetrics & Gynecology , Mugla University School of Medicine , Mugla , Turkey , and.
authors.forename: Nilgün
authors.initials: N
authors.lastname: Turhan
authors.affiliation: d Department of Obstetrics and Gynecology , Gazi University School of Medicine , Ankara , Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kafali
mesh_terms: D000293:Adolescent; D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D010053:Ovary / Q000187:drug effects; D011085:Polycystic Ovary Syndrome / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011446:Prospective Studies; D014463:Ultrasonography; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D003277:Contraceptives, Oral, Combined; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Contraception; hormonal; insulin resistance; polycystic ovary syndrome