title: Urinary tract infections in women with urogynaecological symptoms.
abstract: OBJECTIVE
  Urinary tract infections are common in the field of urogynaecology. Women with persistent urinary symptoms seem more likely to have bacteriuria despite negative cultures. In this review, we will give an overview of the recent insights on the relationship between urinary tract infection and persistent urinary symptoms and possible new therapeutic options.
  
  
  RESULTS
  Recently published articles evaluated the prevalence of low-count bacteriuria (≥10 CFU/ml) or intracellular bacterial communities in women with overactive bladder symptoms (OAB). Differences in urinary microbioma observed in women with and without OAB symptoms were evaluated. In the light of these findings, current screening strategies were discussed and alternative screening methods for bacteriuria developed.
  
  
  CONCLUSIONS
  Low-count bacteriuria (≥10 CFU/ml) seems to be more prevalent in women with OAB. Also intracellular bacterial communities are more commonly detected in these women. The microbioma found in women with urinary symptoms appeared to differ from healthy controls. The current screening methods might be insufficient as they are targeted at detecting uropathogenic Escherichia coli, mostly using a detection threshold of at least 10 CFU/ml and failing to detect intracellular bacterial communities. Studies evaluating the efficacy of treating women with low-count bacteriuria are limited but promising.
authors.affiliation: Department of Obstetrics and Gynaecology, Academic Medical Centre, Amsterdam, the Netherlands.
authors.forename: Marielle M E
authors.initials: MM
authors.lastname: Lakeman
authors.forename: Jan-Paul W R
authors.initials: JP
authors.lastname: Roovers
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D058491:Bacterial Load / Q000187:drug effects*; D001437:Bacteriuria; D005260:Female; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000209:etiology / Q000382:microbiology* / Q000503:physiopathology; D008403:Mass Screening; D012307:Risk Factors; D053201:Urinary Bladder, Overactive / Q000150:complications / Q000382:microbiology* / Q000503:physiopathology; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents