title: Psychiatric and social outcome after deep brain stimulation for advanced Parkinson's disease.
abstract: The aim of this study was to assess psychiatric and social outcome 12 months after bilateral deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) and subthalamic nucleus (STN) for advanced Parkinson's disease (PD).
  
  
  
  We randomly assigned patients to receive GPi DBS (n = 65) or STN DBS (n = 63). Standardized psychiatric and social questionnaires were assessed at baseline and after 12 months.
  
  
  
  No differences were found between GPi DBS and STN DBS on psychiatric evaluation. Within-group comparisons showed small but statistically significant changes on several measures in both groups. Descriptive statistics indicated slight changes in social functioning. Marital satisfaction of patients and partners remained relatively stable after GPi and STN DBS.
  
  
  
  We found neither differences in psychiatric and social outcome between GPi DBS and STN DBS nor any relevant within-group differences. The decision for GPi DBS or STN DBS cannot be based on expected psychiatric or social effects.
authors.affiliation: Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands.|Department of Psychology, University of Amsterdam, The Netherlands.
authors.forename: Judith A
authors.initials: JA
authors.lastname: Boel
authors.affiliation: Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Vincent J J
authors.initials: VJ
authors.lastname: Odekerken
authors.affiliation: Department of Medical Psychology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Gert J
authors.initials: GJ
authors.lastname: Geurtsen
authors.affiliation: Department of Psychology, University of Amsterdam, The Netherlands.|Department of Medical Psychology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Ben A
authors.initials: BA
authors.lastname: Schmand
authors.affiliation: Altrecht Academic Anxiety Center, Utrecht, The Netherlands; Department of Clinical and Health Psychology, Utrecht University, The Netherlands.
authors.forename: Danielle C
authors.initials: DC
authors.lastname: Cath
authors.affiliation: Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Martijn
authors.initials: M
authors.lastname: Figee
authors.affiliation: Department of Neurosurgery, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Pepijn
authors.initials: P
authors.lastname: van den Munckhof
authors.affiliation: Clinical Research Unit, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Rob J
authors.initials: RJ
authors.lastname: de Haan
authors.affiliation: Department of Neurosurgery, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: P Richard
authors.initials: PR
authors.lastname: Schuurman
authors.affiliation: Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Rob M A
authors.initials: RM
authors.lastname: de Bie
mesh_terms: D000328:Adult; D000368:Aged; D046690:Deep Brain Stimulation / Q000523:psychology; D005260:Female; D005917:Globus Pallidus / Q000502:physiology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000523:psychology / Q000628:therapy*; D066107:Social Skills; D020531:Subthalamic Nucleus / Q000502:physiology* / Q000601:surgery; D016896:Treatment Outcome
keywords: Parkinson's disease; deep brain stimulation; psychiatry; randomized controlled trial