title: A molecular switch for selective autophagosome formation.
abstract: Selective macroautophagy (hereafter autophagy) can eliminate large cytotoxic structures that are designated for degradation by autophagy receptors. In our recent paper, we showed that a key function of target-bound autophagy receptors is to activate the autophagy kinase, Atg1, via interactions with the scaffold protein Atg11. Our work thus reveals a mechanism by which target recognition coordinates the earliest steps in autophagosome biogenesis.
authors.affiliation: a Northwest Labs ; Department of Molecular and Cellular Biology ; Harvard University ; Cambridge , MA USA.
authors.forename: Roarke A
authors.initials: RA
authors.lastname: Kamber
authors.affiliation: a Northwest Labs ; Department of Molecular and Cellular Biology ; Harvard University ; Cambridge , MA USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Shoemaker
authors.affiliation: a Northwest Labs ; Department of Molecular and Cellular Biology ; Harvard University ; Cambridge , MA USA.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Denic
keywords: Ape1; Atg1; Atg11; Atg19; Atg36; autophagosome formation; pexophagy; phagophore; selective autophagy