title: Thyroid antibodies in euthyroid and subclinical hypothyroidic pregnant women with autoimmune hypothyroidism: effects on hematological parameters and postpartum hemorrhage.
abstract: OBJECTIVE
  The aim of the study was to investigate the relationship between thyroid antibodies and hematological parameters in euthyroid or subclinical hypothyroidic (S H) pregnant women with autoimmune hypothyroidism and to verity whether these pregnant women are affected by a higher rate of postpartum hemorrhage.
  
  
  METHODS
  Thirty-six out hyroid and 21 S H pregnant women with autoimmune thyroid disease and 52 healthy pregnant women were evaluated. The relationship between thyroid hormones, thyroid antibodies level, the dosage of Levotroxin (LT4) and hematological parameters and the amount of postpartum bleeding was investigated.
  
  
  RESULTS
  The mean platelet volume (MPV), was significantly higher in the SH group than in the euthyroid group and in the euthyroid group than healthy group (p<0.001). Hemoglobin (Hb) was significantly lower in both the SH group and the euthyroid group than control group (p<0.001). Other hematological parameters and the amount of postpartum bleeding did not differ between the groups. The correlation between Hb and fT3, FT4 was significant and positive, whereas between Hb and T SH was significant and negative (r=0.3 p<0.01, r=0.2 p=0.01, and r = -0.18 p=0.04, respectively). There was a significant and negative correlation between the PLT count and FT4, PT and FT3 (r = -0.2 p=0.01, r = -0.3 p<0.01, and r = -0.3 p<0.01, respectively).
  
  
  CONCLUSIONS
  It has been described that being thyroid antibody-positive (TAb+) may be a risk factor for anemia and high MPV. However euthyroid and SH pregnant women with thyroid antibodies do not differ in terms of other coagulation parameters and postpartum hemorrhage from healthy controls.
authors.forename: Esra Bahar
authors.initials: EB
authors.lastname: Gur
authors.forename: Muammer
authors.initials: M
authors.lastname: Karadeniz
authors.forename: Hasbiye
authors.initials: H
authors.lastname: Inceefe
authors.forename: Sumeyra
authors.initials: S
authors.lastname: Tatar
authors.forename: Guluzar Arzu
authors.initials: GA
authors.lastname: Turan
authors.forename: Mine
authors.initials: M
authors.lastname: Genc
authors.forename: Serkan
authors.initials: S
authors.lastname: Guclu
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D050031:Hashimoto Disease / Q000097:blood* / Q000517:prevention & control; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000097:blood*; D015539:Platelet Activation; D006473:Postpartum Hemorrhage / Q000097:blood* / Q000517:prevention & control; D011225:Pre-Eclampsia / Q000097:blood; D011247:Pregnancy; D012720:Severity of Illness Index; D013960:Thyroid Function Tests; D013967:Thyroiditis, Autoimmune / Q000097:blood* / Q000517:prevention & control
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D018828:Immunoglobulins, Thyroid-Stimulating; C056626:thyroid microsomal antibodies