title: Causes of treatment failure for hepatitis C in the era of direct-acting antiviral therapy.
abstract: Hepatitis C therapy in the era of the newer direct-acting antiviral agents has radically changed our treatment schemes by achieving very high rates of sustained virological response. However, treatment with direct antiviral agents fails in a subgroup of patients. This group of so-called difficult-to-treat individuals is the subject of this paper, which reviews the causes of virological failure, their clinical implications, and some final recommendations.
authors.affiliation: Aparato Digestivo/Unidad de Hepatología, Hospital Universitario Marqués de Valdecilla, España.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Cabezas
authors.affiliation: Aparato Digestivo/ Unidad de Hepatologia, Hospital Universitario Marqués de Valdecilla, España.
authors.forename: Susana
authors.initials: S
authors.lastname: Llerena
authors.affiliation: Aparato Digestivo/Unidad de Hepatología, Hospital Universitario Marqués de Valdecilla, España.
authors.forename: Ángela
authors.initials: Á
authors.lastname: Puente
authors.affiliation: Hospital Universitario Marqués de Valdecilla.
authors.forename: Emilio
authors.initials: E
authors.lastname: Fábrega
authors.affiliation: Servicio Aparato Digestivo, Hospital Universitario Marqués de Valdecilla, 39002.
authors.forename: Javier
authors.initials: J
authors.lastname: Crespo
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D024882:Drug Resistance, Viral; D004359:Drug Therapy, Combination; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D017211:Treatment Failure
chemical_list: D000998:Antiviral Agents