title: Role of angiotensin II in stem cell therapy of cardiac disease.
abstract: BACKGROUND
  The renin angiotensin system (RAS) is closely related to the cardiovascular system, body fluid regulation and homeostasis.
  
  
  METHODS
  Despite common therapeutic methods, stem cell/progenitor cell therapy is daily increasing as a term of regenerative medicine. RAS and its pharmacological inhibitors are not only involved in physiological and pathological aspects of the cardiovascular system, but also affect the different stages of stem cell proliferation, differentiation and function, via interfering cell signaling pathways.
  
  
  RESULTS
  This study reviews the new role of RAS, in particular Ang II distinct from other common roles, by considering its regulating impact on the different signaling pathways involved in the cardiac and endothelial tissue, as well as in stem cell transplantation.
  
  
  CONCLUSIONS
  This review focuses on the impact of stem cell therapy on the cardiovascular system, the role of RAS in stem cell differentiation, and the role of RAS inhibition in cardiac stem cell growth and development.
authors.affiliation: Biotechnology Research Center, Tabriz University of Medical Science, Tabriz, Iran Department of Pharmacology and Toxicology, Tabriz University of Medical Science, Tabriz, Iran Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Ahmadian
authors.affiliation: Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran Department of Pharmaceutical Nanotechnology, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Samira
authors.initials: S
authors.lastname: Jafari
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Department of Pharmacognosy, Tabriz University of Medical Sciences, Tabriz, Iran Yarikhosroushahia@tbzmed.ac.ir.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Yari Khosroushahi
mesh_terms: D000804:Angiotensin II / Q000627:therapeutic use*; D000818:Animals; D006331:Heart Diseases / Q000628:therapy*; D006801:Humans; D008954:Models, Biological; D012084:Renin-Angiotensin System; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
chemical_list: D000804:Angiotensin II
keywords: Cardiac tissue; differentiation; endothelial tissue; renin angiotensin system; review; stem cell; transplantation