title: microRNA and Chronic Lymphocytic Leukemia.
abstract: Expression profiling of microRNAs identified important differences in microRNA expression between CLL samples and normal CD5+ B-cells. Researchers have first discussed the dual role of miRNAs working as tumor suppressors (inhibiting malignant potential) or as oncogenes (activating malignant potential) in CLL pathogenesis. Understanding the roles of miRNAs in leukemic cells brings information on a new layer of gene regulation and also provides new markers for improved diagnosis and prognosis, as well as novel therapeutic options for CLL patients. Herein we will focus on the roles of miRNAs in CLL, highlighting what is already known about their function, proposing a novel model of CLL predisposition and progression, and describing the challenges for the near future.
authors.affiliation: Experimental Therapeutics Department, The University of Texas MD Anderson Cancer Center, Unit 1950, 1515 Holcombe Blvd, Houston, TX, 77030-4009, USA. DEGiza@mdanderson.org.|Department of Hematology, Fundeni Clinical Institute, Bucharest, Romania. DEGiza@mdanderson.org.
authors.forename: Dana Elena
authors.initials: DE
authors.lastname: Giza
authors.affiliation: Experimental Therapeutics Department, The University of Texas MD Anderson Cancer Center, Unit 1950, 1515 Holcombe Blvd, Houston, TX, 77030-4009, USA. gecalin2003@yahoo.com.|The RNA Interference and Non-coding RNA Center, MD Anderson Cancer Center, Texas State University, Houston, TX, 77030-4009, USA. gecalin2003@yahoo.com.
authors.forename: George A
authors.initials: GA
authors.lastname: Calin
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics; D018797:Cell Cycle Proteins / Q000235:genetics; D020869:Gene Expression Profiling; D015973:Gene Expression Regulation, Leukemic; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D008957:Models, Genetic
chemical_list: D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D035683:MicroRNAs
keywords: ATM mutation; CLL; IGHV; ZAP-70; miRNAs