title: Manganese Oxide-Coated Carbon Nanotubes As Dual-Modality Lymph Mapping Agents for Photothermal Therapy of Tumor Metastasis.
abstract: Lymph node (LN) status is a major indicator of stage and survival of lung cancer patients. LN dissection is a primary option for lung cancer LN metastasis; however, this strategy elicits adverse effects and great trauma. Therefore, developing a minimally invasive technique to cure LN metastasis of lung cancer is desired. In this study, multiwalled carbon nanotubes (MWNTs) coated with manganese oxide (MnO) and polyethylene glycol (PEG) (namely MWNTs-MnO-PEG) was employed as a lymphatic theranostic agent to diagnose and treat metastatic LNs. After single local injection and lymph drainage were performed, regional LNs were clearly mapped by T1-weighted magnetic resonance (MR) of MnO and dark dye imaging of MWNTs. Meanwhile, metastatic LNs could be simultaneously ablated by near-infrared (NIR) irradiation under the guidance of dual-modality mapping. The excellent result was obtained in mice bearing LNs metastasis models, showing that MWNTs-MnO-PEG as a multifunctional theranostic agent was competent for dual-modality mapping guided photothermal therapy of metastatic LNs.
authors.affiliation: Department of Colorectal Surgery, Fudan University Shanghai Cancer Center , Shanghai 200032, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University , Shanghai 200030, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Yang
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Colorectal Surgery, Fudan University Shanghai Cancer Center , Shanghai 200032, China.
authors.forename: Li-Yong
authors.initials: LY
authors.lastname: Huang
authors.forename: Shun
authors.initials: S
authors.lastname: Shen
authors.affiliation: Department of Colorectal Surgery, Fudan University Shanghai Cancer Center , Shanghai 200032, China.
authors.forename: Sanjun
authors.initials: S
authors.lastname: Cai
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007036:Hypothermia, Induced; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D008207:Lymphatic Metastasis; D008297:Male; D017895:Manganese Compounds / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008819:Mice, Nude; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D010087:Oxides / Q000737:chemistry / Q000494:pharmacology; D010789:Phototherapy
chemical_list: D020099:Coated Materials, Biocompatible; D017895:Manganese Compounds; D037742:Nanotubes, Carbon; D010087:Oxides; C027424:manganese oxide
keywords: dual-modality mapping; lymph nodes metastasis; manganese oxide; multiwalled carbon nanotubes; photothermal therapy; theranostics