title: Assessment of Nephroprotective Potential of Histochrome during Induced Arterial Hypertension.
abstract: Magnetic resonance tomography was employed to verify endothelial dysfunction of renal arteries in Wistar and OXYS rats under conditions of induced arterial hypertension. Angiography revealed changes in the size and form of renal arteries of hypertensive animals. In hypertensive rats, histochrome exerted a benevolent therapeutic effect in renal arteries: it decreased BP, diminished thrombus formation in fi ne capillaries and arterioles, demonstrated the anticoagulant properties, partially improved endothelial dysfunction of small renal arteries, and up-regulated the glomerular filtration.
authors.affiliation: G. B. Elyakov Pacific Ocean Institute of Bioorganic Chemistry, Far-East Division of Russian Academy of Sciences, Novosibirsk, Russia. agafonova@piboc.dvo.ru.
authors.forename: I G
authors.initials: IG
authors.lastname: Agafonova
authors.affiliation: Medical Association, Far-East Division of Russian Academy of Sciences, Vladivostok, Russia.
authors.forename: R N
authors.initials: RN
authors.lastname: Bogdanovich
authors.affiliation: Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.|Novosibirsk State University, Novosibirsk, Russia.
authors.forename: N G
authors.initials: NG
authors.lastname: Kolosova
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D009285:Naphthoquinones / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012077:Renal Artery / Q000187:drug effects
chemical_list: D000925:Anticoagulants; D009285:Naphthoquinones; C103614:histochrome
keywords: OXYS rats; angiography; arterial hypertension; endothelial vasomotor function; magnetic resonance tomography