title: Mechanisms of cell death in neurodegenerative and retinal diseases: common pathway?
abstract: The review intends to draw the attention of researchers working in retinal degenerations on the fact that classical apoptosis, for example, apoptosis triggering caspase activation, may not be the main pathway of cellular demise in this tissue.Former work already showed the difficulty of proving the activation of apoptosis effectors in different models of retinal degeneration. However, these results were not really considered because of the lack of an alternative explanation for cell death. Nowadays, the description of many pathways of cellular demise is filling the gap and other forms of cell death are now described in the retina.The knowledge on the molecular mechanisms of cell death is very important for the development of new therapeutic strategies, as well as for the evaluation of cell death onset in retinal degeneration.
authors.affiliation: aINSERM U1138, Centre de Recherches des Cordeliers, Université Paris Descartes, Université Pierre et Marie Curie, Paris bEcole Nationale Vétérinaire d'Alfort, France.
authors.forename: Alicia
authors.initials: A
authors.lastname: Torriglia
authors.forename: Imene
authors.initials: I
authors.lastname: Jaadane
authors.forename: Cecile
authors.initials: C
authors.lastname: Lebon
mesh_terms: D000818:Animals; D020169:Caspases / Q000378:metabolism*; D016923:Cell Death / Q000502:physiology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism; D012160:Retina / Q000187:drug effects / Q000378:metabolism*; D012162:Retinal Degeneration / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D020169:Caspases