title: Prophylaxis of Venous Thrombosis in Neurocritical Care Patients: An Evidence-Based Guideline: A Statement for Healthcare Professionals from the Neurocritical Care Society.
abstract: The risk of death from venous thromboembolism (VTE) is high in intensive care unit patients with neurological diagnoses. This is due to an increased risk of venous stasis secondary to paralysis as well as an increased prevalence of underlying pathologies that cause endothelial activation and create an increased risk of embolus formation. In many of these diseases, there is an associated risk from bleeding because of standard VTE prophylaxis. There is a paucity of prospective studies examining different VTE prophylaxis strategies in the neurologically ill. The lack of a solid evidentiary base has posed challenges for the establishment of consistent and evidence-based clinical practice standards. In response to this need for guidance, the Neurocritical Care Society set out to develop and evidence-based guideline using GRADE to safely reduce VTE and its associated complications.
authors.affiliation: Departments of Neurology, Anesthesia/Critical Care Medicine, Neurosurgery, and General Internal Medicine, John Hopkins School of Medicine, 733 N Broadway, Baltimore, MD, 21205, USA. pnyquis1@jhmi.edu.
authors.forename: Paul
authors.initials: P
authors.lastname: Nyquist
authors.affiliation: Department of Nursing, Neuroscience CNS, Yale-New Haven Hospital, New Haven, CT, 06510, USA. cynthia.bautista@ynhh.org.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Bautista
authors.affiliation: Department of Neurology and Critical Care, McMaster University, 1280 Main Street W, Hamilton, ON, L8S 4L8, Canada. draga.jichici@mcmaster.ca.
authors.forename: Draga
authors.initials: D
authors.lastname: Jichici
authors.affiliation: Department of Neurology, Lahey Hospital and Medical Center, 41 Mall Road, Burlington, MA, 01805, USA. joseph.burns@lahey.org.
authors.forename: Joseph
authors.initials: J
authors.lastname: Burns
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, 55 Fruit Street, Boston, MA, 02114-2696, USA. schhangani@mgh.harvard.edu.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Chhangani
authors.affiliation: Department of Nursing, Morristown Medical Center, 100 Madison Ave, Morristown, NJ, 07960, USA. michele.defilippis@atlantichealth.org.
authors.forename: Michele
authors.initials: M
authors.lastname: DeFilippis
authors.affiliation: Department of Neurology, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL, 60637, USA. fgoldenb@neurology.bsd.uchicago.edu.
authors.forename: Fernando D
authors.initials: FD
authors.lastname: Goldenberg
authors.affiliation: Department of Neurosurgery, University of Illinois Hospital & Health Sciences System, 833 South Wood Street, RM164 MC886, Chicago, IL, 60612, USA. skim42@uic.edu.
authors.forename: Keri
authors.initials: K
authors.lastname: Kim
authors.affiliation: Division of Surgical Critical Care, Orlando Regional Medical Center, 1414 Kuhl Ave, MP180, Orlando, FL, 32806, USA. xiliu713@icloud.com.
authors.forename: Xi
authors.initials: X
authors.lastname: Liu-DeRyke
authors.affiliation: Department of Neurosurgery, Los Angeles County University Southern California Medical Center, 1520 San Pablo St, Los Angeles, CA, 90033, USA. wjmack@gmial.com.
authors.forename: William
authors.initials: W
authors.lastname: Mack
authors.affiliation: Department of Neurosurgery, University of Louisville Physicians, 401 E Chestnut St, Louisville, KY, 40202, USA. ksmeyer21@gmail.com.
authors.forename: Kim
authors.initials: K
authors.lastname: Meyer
mesh_terms: D003422:Critical Care / Q000592:standards*; D019317:Evidence-Based Medicine / Q000592:standards*; D006801:Humans; D009462:Neurology / Q000592:standards*; D017410:Practice Guidelines as Topic / Q000592:standards*; D012955:Societies, Medical / Q000592:standards*; D054556:Venous Thromboembolism / Q000517:prevention & control*
keywords: Intracranial hemorrhage; Pulmonary embolus; Stroke; Subarachnoid hemorrhage; Traumatic brain injury; Venous thrombus