title: DNA repair and aging: the impact of the p53 family.
abstract: Cells are constantly exposed to endogenous and exogenous factors that threaten the integrity of their DNA. The maintenance of genome stability is of paramount importance in the prevention of both cancer and aging processes. To deal with DNA damage, cells put into operation a sophisticated and coordinated mechanism, collectively known as DNA damage response (DDR). The DDR orchestrates different cellular processes, such as DNA repair, senescence and apoptosis. Among the key factors of the DDR, the related proteins p53, p63 and p73, all belonging to the same family of transcription factors, play multiple relevant roles. Indeed, the members of this family are directly involved in the induction of cell cycle arrest that is necessary to allow the cells to repair. Alternatively, they can promote cell death in case of prolonged or irreparable DNA damage. They also take part in a more direct task by modulating the expression of core factors involved in the process of DNA repair or by directly interacting with them. In this review we will analyze the fundamental roles of the p53 family in the aging process through their multifaceted function in DDR.
authors.affiliation: Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Nicolai
authors.affiliation: Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Antonello
authors.initials: A
authors.lastname: Rossi
authors.affiliation: Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Di Daniele
authors.affiliation: Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy.|Medical Research Council, Toxicology Unit, Hodgkin Building, Leicester University, Leicester LE1 9HN, UK.
authors.forename: Gerry
authors.initials: G
authors.lastname: Melino
authors.affiliation: Biochemistry Laboratory, IDI-IRCCS, 00100 Rome, Italy.
authors.forename: Margherita
authors.initials: M
authors.lastname: Annicchiarico-Petruzzelli
authors.affiliation: ENEA Research Center Casaccia, Laboratory of Biosafety and Risk Assessment, 00123 Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Raschellà
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D004260:DNA Repair / Q000502:physiology*; D005786:Gene Expression Regulation; D008322:Mammals / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53
keywords: DNA repair; aging; homologous recombination; non homologous end joining; p53; p63; p73