title: S-100 Negative Granular Cell Tumor of the Oral Cavity.
abstract: Classic granular cell tumor is a mesenchymal neoplasm that commonly occurs on the skin, but is not infrequently found in the oral cavity, primarily on the dorsal tongue. Diagnosis is usually straightforward with hematoxylin and eosin stained slides. Immunohistochemical studies on classic granular cell tumor shows positive immunostaining for S-100 and vimentin, while CD68 is variably positive. We report a case of otherwise unremarkable oral granular cell tumor that was immunohistochemically negative for S-100, and positive for vimentin and CD68, and discuss the differential diagnosis. The results of the immunohistochemical studies in our case are compared with those of classic S-100 positive oral granular cell tumors, as well as cutaneous and oral S-100 negative granular cell tumors. Classic S-100 positive granular cell tumors and S-100 negative granular cell tumors of the oral cavity can only be distinguished by immunohistochemical studies; however, the necessity of this distinction is unclear, as both are benign lesions in which recurrence is unlikely.
authors.affiliation: Department of Diagnostic Sciences, College of Dental Medicine, #7377, Nova Southeastern University, 3200 S. University Drive, Fort Lauderdale, FL, 33328-2018, USA. lynn.solomon@gmail.com.
authors.forename: Lynn W
authors.identifier: http://orcid.org/0000-0002-1670-6214
authors.initials: LW
authors.lastname: Solomon
authors.affiliation: Department of Diagnostic Sciences, College of Dental Medicine, #7377, Nova Southeastern University, 3200 S. University Drive, Fort Lauderdale, FL, 33328-2018, USA.
authors.forename: Ines
authors.initials: I
authors.lastname: Velez
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D002648:Child; D016586:Granular Cell Tumor / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009062:Mouth Neoplasms / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; D009418:S100 Proteins
keywords: Granular cell tumor; Immunohistochemistry; Neoplasm; Oral cavity; Primitive nonneural granular cell tumor; S-100 negative