title: Circulating resistin is a significant predictor of mortality independently from cardiovascular comorbidities in elderly, non-diabetic subjects with chronic kidney disease.
abstract: BACKGROUND
  Resistin is associated with inflammation, atherosclerosis and cardiovascular (CV) disease.
  
  
  OBJECTIVE
  To associate circulating resistin with all-cause and CV mortality in chronic kidney disease (CKD) patients.
  
  
  METHODS
  Serum resistin was determined in a cohort of 80 elderly, non-diabetic patients with stable CKD at different stages in a follow-up period of 5 years.
  
  
  RESULTS
  Circulating resistin was significantly elevated in deceased compared to alive patients. Resistin emerged as an independent biomarker of all-cause and CV mortality after a 5-year follow-up period.
  
  
  CONCLUSIONS
  Elevated circulating resistin was a significant independent predictor of CV and all-cause mortality in elderly, non-diabetic CKD patients.
authors.affiliation: a Department of Clinical Biochemistry .|b Renal Unit, Medical School, "Attikon" General University Hospital, National and Kapodistrian University of Athens, School of Medicine , Athens , Greece , and.
authors.forename: Anna
authors.initials: A
authors.lastname: Marouga
authors.affiliation: a Department of Clinical Biochemistry .
authors.forename: Maria
authors.initials: M
authors.lastname: Dalamaga
authors.affiliation: c Department of Informatics , Athens University of Economics and Business , Athens , Greece.
authors.forename: Anastasia N
authors.initials: AN
authors.lastname: Kastania
authors.affiliation: a Department of Clinical Biochemistry .
authors.forename: Christos
authors.initials: C
authors.lastname: Kroupis
authors.affiliation: a Department of Clinical Biochemistry .
authors.forename: Maria
authors.initials: M
authors.lastname: Lagiou
authors.affiliation: a Department of Clinical Biochemistry .
authors.forename: Koralia
authors.initials: K
authors.lastname: Saounatsou
authors.affiliation: a Department of Clinical Biochemistry .
authors.forename: Kleanthi
authors.initials: K
authors.lastname: Dimas
authors.affiliation: b Renal Unit, Medical School, "Attikon" General University Hospital, National and Kapodistrian University of Athens, School of Medicine , Athens , Greece , and.
authors.forename: Demetrios V
authors.initials: DV
authors.lastname: Vlahakos
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000401:mortality; D015897:Comorbidity; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D052243:Resistin / Q000097:blood*
chemical_list: D015415:Biomarkers; C499624:RETN protein, human; D052243:Resistin
keywords: Adipokine; adipose tissue; cytokine; morbidity; renal disease