title: Beating Cancer with a Gut Feeling.
abstract: Blockade of immune checkpoint molecules, a group of molecules normally involved in maintaining self-tolerance and limiting T cell responses, has emerged as a breakthrough in cancer therapy. Two recent studies published in Science show that, in mice, gut commensal microbes promote antitumor immunity and may determine therapy efficacy.
authors.affiliation: Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
authors.forename: Sayeh
authors.initials: S
authors.lastname: Gorjifard
authors.affiliation: Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: rgoldszmid@mail.nih.gov.
authors.forename: Romina S
authors.initials: RS
authors.lastname: Goldszmid
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D000069196:Gastrointestinal Microbiome / Q000276:immunology*; D041981:Gastrointestinal Tract / Q000382:microbiology*; D007108:Immune Tolerance; D051379:Mice; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology