title: SEOM clinical guidelines for diagnosis and treatment of metastatic colorectal cancer 2015.
abstract: Colorectal cancer (CRC) is the second leading cause of cancer dead in Spain. About half the patients will eventually develop distant metastases. However, as treatment options are expanding, prognosis has steadily improved over the last decades. Management of advanced CRC should be discussed within an experienced multidisciplinary team to select the most appropriate systemic treatment (chemotherapy and targeted agents) and to integrate surgical or ablative procedures when indicated. Disease site and extent, resectability, tumor biology and gene mutations, clinical presentation, patient preferences, and comorbidities are key factors to design a customized treatment plan. The aim of these guidelines is to provide synthetic recommendations for managing advanced CRC patients.
authors.affiliation: Servicio de Oncología Médica. Instituto Maimónides de Investigación Biomédica (IMIBIC), Hospital Reina Sofía, Universidad de Córdoba, Córdoba, Spain. earandaa@seom.org.|Red Tematica de Investigación Cooperativa en Cancer (RTICC), ISCiii, Ministerio de Economía y Competitividad, Madrid, Spain. earandaa@seom.org.
authors.forename: E
authors.initials: E
authors.lastname: Aranda
authors.affiliation: Hospital Universitario y Politécnico La Fe, Valencia, Spain. japariciou@seom.org.
authors.forename: J
authors.initials: J
authors.lastname: Aparicio
authors.affiliation: Red Tematica de Investigación Cooperativa en Cancer (RTICC), ISCiii, Ministerio de Economía y Competitividad, Madrid, Spain.|Hospital Universitario Miguel Servet, Zaragoza, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Alonso
authors.affiliation: Harvard T.H. Chan School of Public Health, Boston, USA.
authors.forename: X
authors.initials: X
authors.lastname: Garcia-Albeniz
authors.affiliation: Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Garcia-Alfonso
authors.affiliation: Institut Català d'Oncologia (L'Hospitalet, Barcelona), Barcelona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Salazar
authors.affiliation: Complexo Hospitalario Universitario, A Coruña, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Valladares
authors.affiliation: Complejo Hospitalario de Navarra, Pamplona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Vera
authors.affiliation: Red Tematica de Investigación Cooperativa en Cancer (RTICC), ISCiii, Ministerio de Economía y Competitividad, Madrid, Spain.|Hospital Universitario Central de Asturias, Oviedo, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Vieitez
authors.affiliation: Red Tematica de Investigación Cooperativa en Cancer (RTICC), ISCiii, Ministerio de Economía y Competitividad, Madrid, Spain.|Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Garcia-Carbonero
mesh_terms: D002986:Clinical Trials as Topic; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D003131:Combined Modality Therapy; D019468:Disease Management; D055088:Early Detection of Cancer; D006801:Humans; D008495:Medical Oncology; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D017410:Practice Guidelines as Topic / Q000592:standards*; D011379:Prognosis; D012955:Societies, Medical
keywords: Chemotherapy; Colorectal cancer; Guidelines; Metastases; Surgery; Targeted agents