title: [Immunocorrection in combined prevention of early postoperative complications in patients with systemic vasculitis].
abstract: The authors studied peculiarities of the immune status in angiosurgical patients with systemic vasculitis, as well as possibilities of immunodiagnosis and immunocorrection in prevention of early coagulopathic and reparative complications after angiosurgical interventions in this cohort of patients. A total of 172 angiosurgical patients presenting with systemic vasculitis were subdivided into two groups depending on the preoperative preparation methods used. In Group One (Study Group) comprising 81 patients preoperative preparation was carried out using immunosuppressive therapy with hormones and cytostatics according to the rheumatologist's indications. In Group Two (n=91) hormones and/or cytostatics were replaced by the proposed four-component immunocorrection including various combinations of correcting the lifestyle, use of antioxidative-activity immunomodulators, plasmapheresis and intravenous administration of immunoglobulins. It was determined that using this method of correction made it possible to achieve a good anti-inflammatory effect in angiosurgical patients with systemic vasculitis, thus avoiding negative aftermaths of immunosuppression. The developed method of immunocorrection makes it possible to decrease the rate of early postoperative coagulopathic and reparative complications in angiosurgical patients as compared to therapy with hormones and/or cytostatics.
authors.affiliation: Department of Hospital Surgery, South Urals State Medical University of the RF Public Health Ministry, Chelyabinsk, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Andrievskikh
authors.affiliation: Cardiovascular Surgery Unit No 1, Regional Clinical Hospital, Chelyabinsk, Russia.
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Omel'ianiuk
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007113:Immunity, Innate; D007165:Immunosuppression Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control*; D011300:Preoperative Care / Q000379:methods*; D012189:Retrospective Studies; D056647:Systemic Vasculitis / Q000276:immunology / Q000628:therapy*; D013997:Time Factors; D055815:Young Adult