title: Trace Analysis of Sinomenine Hydrochloride Using CdTe/CdS Quantum Dots-enhanced Chemiluminescence.
abstract: A novel flow-injection chemiluminescence (FI-CL) method was described for the determination of sinomenine hydrochloride (SIN). The method was based on the inhibitory effect of SIN on the CL reaction of luminol and K3Fe(CN)6 in an alkaline solution, which was sensitized by CdTe/CdS quantum dots (QDs). Under the optimized conditions, the linear range for the determination of SIN was 1.0 × 10(-8) to 1.4 × 10(-6) mol/L. The detection limit was 7.5 × 10(-9) mol/L, and the relative standard deviation was 2.47% (n = 11). The current CL method was applied to determine SIN in pharmaceutical formulations and biological fluids with satisfactory results. The possible CL reaction mechanism was discussed briefly.
authors.affiliation: School of Chemistry and Material Science, Shanxi Normal University.
authors.forename: Kegang
authors.initials: K
authors.lastname: Wu
authors.forename: Suqin
authors.initials: S
authors.lastname: Han
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry*; D005292:Ferricyanides / Q000737:chemistry; D017022:Flow Injection Analysis / Q000295:instrumentation / Q000379:methods*; D007700:Kinetics; D057230:Limit of Detection; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods*; D008165:Luminol / Q000737:chemistry; D009019:Morphinans / Q000032:analysis*; D045663:Quantum Dots / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry*; D013691:Tellurium / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D005292:Ferricyanides; D009019:Morphinans; D013440:Sulfides; C034939:cadmium sulfide; D008165:Luminol; C009271:sinomenine; D013691:Tellurium; C028337:cadmium telluride; C028033:potassium ferricyanide