title: Local cryosurgery and imiquimod: A successful combination for the treatment of locoregional cutaneous metastasis of melanoma: A case series.
abstract: Locoregional cutaneous metastases of melanoma (LCMM) represent a therapeutic challenge. Many treatment options are available with varying results. The combination of cryotherapy and imiquimod, two treatments with a possible synergistic effect, has not yet been described for treating this disease. In this paper, we aimed to show the response of LCMM to cryotherapy combined with topical imiquimod 5%. A retrospective review of 20 patients diagnosed with LCMM and treated with cryotherapy combined with topical imiquimod 5% between November 2000 and May 2014 at three institutions was performed. The locoregional cutaneous response was evaluated. After a mean of five sessions, 13 patients (65%) responded to treatment, eight (40%) of these completely and five (25%) partially. Systemic disease progressed in 16 (80%) patients. Cryotherapy followed by topical imiquimod 5% is simple to apply, has minimal adverse effects and provides response rates similar to other, more complex treatment options.
authors.affiliation: Department of Dermatology, Instituto Valenciano de Oncología, Valencia, Spain.
authors.forename: Nancy
authors.initials: N
authors.lastname: Rivas-Tolosa
authors.affiliation: Department of Dermatology, Hospital Universitario Arnau de Vilanova, Lleida, Spain.
authors.forename: Ariadna
authors.initials: A
authors.lastname: Ortiz-Brugués
authors.affiliation: Department of Dermatology, Hospital General de Jerez de la Frontera, Cádiz, Spain.
authors.forename: Tomás
authors.initials: T
authors.lastname: Toledo-Pastrana
authors.affiliation: Department of Dermatology, Hospital Universitario Arnau de Vilanova, Lleida, Spain.
authors.forename: Manel
authors.initials: M
authors.lastname: Baradad
authors.affiliation: Department of Pathology, Instituto Valenciano de Oncología, Valencia, Spain.
authors.forename: Víctor
authors.initials: V
authors.lastname: Traves
authors.affiliation: Department of Medical Oncology, Instituto Valenciano de Oncología, Valencia, Spain.
authors.forename: Virtudes
authors.initials: V
authors.lastname: Soriano
authors.affiliation: Department of Dermatology, Hospital Universitario Arnau de Vilanova, Lleida, Spain.
authors.forename: Verónica
authors.initials: V
authors.lastname: Sanmartín
authors.affiliation: Department of Dermatology, Instituto Valenciano de Oncología, Valencia, Spain.
authors.forename: Celia
authors.initials: C
authors.lastname: Requena
authors.affiliation: Department of Dermatology, Hospital Universitario Arnau de Vilanova, Lleida, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Martí
authors.affiliation: Department of Dermatology, Instituto Valenciano de Oncología, Valencia, Spain.
authors.forename: Eduardo
authors.identifier: http://orcid.org/0000-0003-3433-8707
authors.initials: E
authors.lastname: Nagore
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D000634:Aminoquinolines / Q000008:administration & dosage / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003452:Cryosurgery; D005260:Female; D006801:Humans; D000077271:Imiquimod; D008297:Male; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod
keywords: cryotherapy; imiquimod; locoregional cutaneous metastases; melanoma; treatment