title: Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [¹¹C]ABP688.
abstract: The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in the pathophysiology of mood and anxiety disorders and is a potential treatment target in major depressive disorder (MDD). This study compared brain mGluR5 binding in elderly patients suffering from MDD with that in elderly healthy volunteers using positron emission tomography (PET) and [(11)C]ABP688. Twenty elderly (mean age: 63.0 ± 6.3) subjects with MDD and twenty-two healthy volunteers in the same age range (mean age: 66.4 ± 7.3) were examined with PET after a single bolus injection of [(11)C]ABP688, with many receiving arterial sampling. PET images were analyzed on a region of interest and a voxel level to compare mGluR5 binding in the brain between the two groups. Differences in [(11)C]ABP688 binding between patients with early- and late-onset depression were also assessed. In contrast to a previously published report in a younger cohort, no significant difference in [(11)C]ABP688 binding was observed between elderly subjects with MDD and healthy volunteers. [(11)C]ABP688 binding was also similar between subgroups with early- or late-onset depression. We believe this is the first study to examine mGluR5 expression in depression in the elderly. Although future work is required, results suggest potential differences in the pathophysiology of elderly depression versus depression earlier in life.
authors.affiliation: Department of Psychiatry, Columbia University, New York, NY, USA.|Department of Psychiatry, Stony Brook University, Stony Brook, NY, USA.
authors.forename: C
authors.initials: C
authors.lastname: DeLorenzo
authors.affiliation: Novartis Institute for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Sovago
authors.affiliation: Department of Psychiatry, Stony Brook University, Stony Brook, NY, USA.
authors.forename: J
authors.initials: J
authors.lastname: Gardus
authors.affiliation: Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA.
authors.forename: J
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Preventive Medicine, Stony Brook University, Stony Brook, NY, USA.
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.affiliation: Novartis Pharmaceuticals Corporations, East Hanover, NJ, USA.
authors.forename: R
authors.initials: R
authors.lastname: Behrje
authors.affiliation: Department of Psychiatry, Columbia University, New York, NY, USA.
authors.forename: J S D
authors.initials: JS
authors.lastname: Kumar
authors.affiliation: Department of Psychiatry, Columbia University, New York, NY, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Devanand
authors.affiliation: Department of Psychiatry, Columbia University, New York, NY, USA.
authors.forename: G H
authors.initials: GH
authors.lastname: Pelton
authors.affiliation: Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Mathis
authors.affiliation: Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: N S
authors.initials: NS
authors.lastname: Mason
authors.affiliation: Novartis Institute for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Gomez-Mancilla
authors.affiliation: Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: H
authors.initials: H
authors.lastname: Aizenstein
authors.affiliation: Department of Psychiatry, Columbia University, New York, NY, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Mann
authors.affiliation: Department of Psychiatry, Stony Brook University, Stony Brook, NY, USA.
authors.forename: R V
authors.initials: RV
authors.lastname: Parsey
mesh_terms: D000368:Aged; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D003865:Major Depressive Disorder / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010091:Oximes; D010865:Pilot Projects; D049268:Positron-Emission Tomography; D011725:Pyridines; D064529:Receptor, Metabotropic Glutamate 5 / Q000378:metabolism*
chemical_list: C510950:3-(6-methylpyridin-2-ylethynyl)cyclohex-2-enone-O-methyloxime; D002250:Carbon Radioisotopes; D010091:Oximes; D011725:Pyridines; D064529:Receptor, Metabotropic Glutamate 5