title: Role of pressure-sensitive adhesives in transdermal drug delivery systems.
abstract: Transdermal drug delivery systems (TDDS) are employed for the delivery of drugs across skin into the systemic circulation. Pressure-sensitive adhesive (PSA) is one of the most critical components used in a TDDS. The primary function of PSA is to help in adhesion of patch to skin, but more importantly it acts as a matrix for the drug and other excipients. Hence, apart from adhesion of the patch, PSA also affects other critical quality attributes of the TDDS such as drug delivery, flux through skin and physical and chemical stability of the finished product. This review article provides a summary of the adhesives used in various types of TDDS. In particular, this review will cover the design types of TDDS, categories of PSAs and their evaluation and regulatory aspects.
authors.affiliation: Amneal Pharmaceuticals, 1 New England Ave, Piscataway, NJ, 08854 USA.
authors.forename: Shabbir
authors.initials: S
authors.lastname: Lobo
authors.affiliation: Amneal Pharmaceuticals, 1 New England Ave, Piscataway, NJ, 08854 USA.
authors.forename: Sameer
authors.initials: S
authors.lastname: Sachdeva
authors.affiliation: Amneal Pharmaceuticals, 1 New England Ave, Piscataway, NJ, 08854 USA.
authors.forename: Tarun
authors.initials: T
authors.lastname: Goswami
mesh_terms: D000269:Adhesives / Q000737:chemistry*; D000279:Administration, Cutaneous; D016503:Drug Delivery Systems; D015195:Drug Design; D005079:Excipients / Q000737:chemistry; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism; D011312:Pressure; D012869:Skin Absorption; D057968:Transdermal Patch
chemical_list: D000269:Adhesives; D005079:Excipients; D004364:Pharmaceutical Preparations