title: Solubility of Naproxen in Polyethylene Glycol 200 + Water Mixtures at Various Temperatures.
abstract: The solubility of naproxen in binary mixtures of polyethylene glycol 200 (PEG 200) + water at the temperature range from 298.0 K to 318.0 K were reported. The combinations of Jouyban-Acree model + van't Hoff and Jouyban-Acree model + partial solubility parameters were used to predict the solubility of naproxen in PEG 200 + water mixtures at different temperatures. Combination of Jouyban-Acree model with van't Hoff equation can be used to predict solubility in PEG 200 + water with only four solubility data in mono-solvents. The obtained solubility calculation errors vary from ~ 17 % up to 35 % depend on the number of required input data. Non-linear enthalpy-entropy compensation was found for naproxen in the investigated solvent system and the Jouyban-Acree model provides reasonably accurate mathematical descriptions of the thermodynamic data of naproxen in the investigated binary solvent systems.
authors.affiliation: Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Panahi-Azar
authors.affiliation: Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Shahla
authors.initials: S
authors.lastname: Soltanpour
authors.affiliation: Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Universidad Nacional de Colombia, Bogotá D.C., Colombia.
authors.forename: Fleming
authors.initials: F
authors.lastname: Martinez
authors.affiliation: Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. ; Pharmaceutical Engineering Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
authors.forename: Abolghasem
authors.initials: A
authors.lastname: Jouyban
keywords: Jouyban–acree model; Naproxen; Solubility; Thermodynamic analysis