title: Melanoma of the sinonasal mucosa: A report on the two cases and a review of the literature.
abstract: BACKGROUND
  Primary mucosal melanoma of the sinonasal tract is a rare neoplasm, accounting for less than 1% of all melanomas. It has an aggressive and unpredictable biologic behavior characterized by frequent incidence of local recurrence, local and distant metastasis of the disease.
  
  
  METHODS
  This report summarizes the results of the previous research concerning sinonasal mucosal melanoma, and by the example of the two patients suffering from mucosal melanoma, we described clinical and histopathological features of this rare neoplasm and our experience in its diagnosis and treatment.
  
  
  CONCLUSIONS
  Only histopathological analysis complemented by immunobistochemical analysis contributes to early and accurate diagnosis of the disease.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Aleksić
authors.forename: Radoslav
authors.initials: R
authors.lastname: Gajanin
authors.forename: Dejan
authors.initials: D
authors.lastname: Djurdjević
authors.forename: Zorica
authors.initials: Z
authors.lastname: Novaković
authors.forename: Dalibor
authors.initials: D
authors.lastname: Vranjes
authors.forename: Slobodan
authors.initials: S
authors.lastname: Spremo
authors.forename: Dmitar
authors.initials: D
authors.lastname: Travar
authors.forename: Natasa
authors.initials: N
authors.lastname: Guzina-Golac
authors.forename: Vesna
authors.initials: V
authors.lastname: Tomić-Spirić
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D009297:Nasal Mucosa / Q000737:chemistry / Q000187:drug effects / Q000473:pathology* / Q000601:surgery; D010166:Palliative Care; D010255:Paranasal Sinus Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D010256:Paranasal Sinuses / Q000737:chemistry / Q000187:drug effects / Q000473:pathology* / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor