title: Comparison of a Point-Of-Care Test for High-Sensitivity C-Reactive Protein with an Established Immuno-Nephelometric Method.
abstract: BACKGROUND
  High-sensitivity C-reactive protein (hsCRP) is an established marker of cardiovascular risk particularly in primary prevention. For years, it was exclusively measured using automated methods in clinical laboratories, but point-of-care tests (POCT) are urgently needed to simplify and hasten the determination of hsCRP.
  
  
  METHODS
  This study compared a novel hsCRP POCT with an established nephelometric method in 104 patients showing a broad spectrum of cardiovascular risk.
  
  
  RESULTS
  The results indicated a moderate agreement of the POCT with the standard method, with a sensitivity of 87% and a specificity of 80% to detect elevated hsCRP (> 1 mg/L).
  
  
  CONCLUSIONS
  The minimization of sample volume appears to be the most promising strategy for future test improvement.
authors.forename: Sinisa
authors.initials: S
authors.lastname: Markovic
authors.forename: Franz Paul
authors.initials: FP
authors.lastname: Armbruster
authors.forename: Thomas Bernd
authors.initials: TB
authors.lastname: Dschietzig
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Koenig
mesh_terms: D002097:C-Reactive Protein / Q000737:chemistry*; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis*; D002624:Chemistry, Clinical; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009391:Nephelometry and Turbidimetry; D000067716:Point-of-Care Testing; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D002097:C-Reactive Protein