title: SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME IMIDAZO[2,1-b][1,3,4]THIADIAZOLE DERIVATIVES.
abstract: A number of imidazo[2,1-b][1,3,4]thiadiazole derivatives having alkyl and aryl moieties attached to positions 2 and 6 of imidazo[2,1-b][1,3,4]thiadiazole nucleus, respectively, were prepared and characterized by IR, NMR and mass spectroscopy. Antiinflammatory activity was evaluated by carrageenan-induced rat paw edema assay. By 5th hours, all compounds demonstrated anti-inflammatory activity similar or higher than that of standard NSAID, ibuprofen.
authors.forename: Subhas S
authors.initials: SS
authors.lastname: Karki
authors.forename: Vivek
authors.initials: V
authors.lastname: Rana
authors.forename: Ramjith U
authors.initials: RU
authors.lastname: Sivan
authors.forename: Sujeet
authors.initials: S
authors.lastname: Kumar
authors.forename: Vinayakumar
authors.initials: V
authors.lastname: Renuka
authors.forename: Sureshbabu A
authors.initials: SA
authors.lastname: Ramareddy
authors.forename: Prasanna G
authors.initials: PG
authors.lastname: Subbarao
authors.forename: Sudam C
authors.initials: SC
authors.lastname: Si
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D007093:Imidazoles; D013830:Thiadiazoles