title: Serum Protein Thiol Levels in Patients with Hospital-Acquired Acute Kidney Injury.
abstract: OBJECTIVE
  This study aimed to examine antioxidants in patients with acute kidney injury (AKI) and determine whether serum protein thiol levels are associated with all-cause 90-day mortality in patients with hospital-acquired AKI.
  
  
  METHODS
  According to the RIFLE criteria, 160 patients with hospital-acquired AKI were enrolled in our prospective cohort study. As controls, 72 critically ill patients without AKI and 72 age and sex-matched healthy subjects were also recruited. Serum protein thiol levels were analyzed in relation to all-cause mortality of patients with AKI.
  
  
  RESULTS
  Serum protein thiol levels in AKI patients were lower than those in healthy people (p=0.010). Protein thiol levels showed a weak but significant positive correlation with serum albumin levels. The 90-day overall mortality rate was higher in AKI patients with high serum protein thiol levels than in those with low levels (p=0.032 by log rank test). In multivariate analysis (Cox regression), serum protein thiol levels (p=0.031) were independently associated with 90-day overall mortality after adjustment for age, sex, sepsis, and the Acute Physiology and Chronic Health Evaluation II score.
  
  
  CONCLUSIONS
  Patients with hospital-acquired AKI have remarkably low serum protein thiol levels. Elevated protein thiol levels are associated with 90-day overall mortality in hospital-acquired AKI.
authors.affiliation: Division of Nephrology, the Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Qian
authors.forename: Junyan
authors.initials: J
authors.lastname: Fang
authors.forename: Qiuyu
authors.initials: Q
authors.lastname: Zhu
authors.forename: Shuai
authors.initials: S
authors.lastname: Ma
authors.forename: Wenji
authors.initials: W
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zheng
authors.forename: Guihua
authors.initials: G
authors.lastname: Hao
authors.forename: Bo
authors.initials: B
authors.lastname: Deng
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Zhao
authors.forename: Feng
authors.initials: F
authors.lastname: Ding
mesh_terms: D018806:APACHE; D058186:Acute Kidney Injury / Q000097:blood* / Q000401:mortality*; D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000032:analysis*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D016638:Critical Illness / Q000401:mortality; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018570:Risk Assessment; D012709:Serum Albumin / Q000032:analysis; D013438:Sulfhydryl Compounds / Q000097:blood*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D001798:Blood Proteins; D012709:Serum Albumin; D013438:Sulfhydryl Compounds