title: The Janus soul of centrosomes: a paradoxical role in disease?
abstract: The centrosome is the main microtubule organizing center of animal cells. It contributes to spindle assembly and orientation during mitosis and to ciliogenesis in interphase. Numerical and structural defects in this organelle are known to be associated with developmental disorders such as dwarfism and microcephaly, but only recently, the molecular mechanisms linking centrosome aberrations to altered physiology are being elucidated. Defects in centrosome number or structure have also been described in cancer. These opposite clinical outcomes--arising from reduced proliferation and overproliferation respectively--can be explained in light of the tissue- and developmental-specific requirements for centrosome functions. The pathological outcomes of centrosome deficiencies have become clearer when considering its consequences. Among them, there are genetic instability (mainly aneuploidy, a defect in chromosome number), defects in the symmetry of cell division (important for cell fate specification and tissue architecture) and impaired ciliogenesis. In this review, we discuss the origins and the consequences of centrosome flaws, with particular attention on how they contribute to developmental diseases.
authors.affiliation: Institut Curie, PSL Research University, CNRS UMR144, 12 rue Lhomond, 75005, Paris, France.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Nano
authors.affiliation: Institut Curie, PSL Research University, CNRS UMR144, 12 rue Lhomond, 75005, Paris, France. renata.basto@curie.fr.
authors.forename: Renata
authors.initials: R
authors.lastname: Basto
mesh_terms: D000782:Aneuploidy; D000818:Animals; D018385:Centrosome / Q000378:metabolism* / Q000473:pathology; D043171:Chromosomal Instability; D002877:Chromosomes, Human / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
keywords: Aneuploidy; Cancer; Centrosome; Centrosome amplification; Centrosome loss; Microcephaly