title: Chemical Composition of Blumea lacera Essential Oil from Nepal. Biological Activities of the Essential Oil and (Z)-Lachnophyllum Ester.
abstract: The essential oil from the aerial parts of Blumea lacera collected from Biratnagar, Nepal, has been obtained by hydrodistillation and analyzed by gas chromatography - mass spectrometry. The major component from the oil, (Z)-lachnophyllum ester, was isolated by preparative silica gel chromatography. B. lacera oil was dominated by (Z)-lachnophyllum ester (25.5%), (Z)-lachnophyllic acid (17.0%), germacrene D (11.0%), (E)-β-farnesene (10.1%), bicyclogermacrene (5.2%), (E)-caryophyllene (4.8%), and (E)-nerolidol (4.2%). Also detected in the oil were (E)-lachnophyllic acid (3.3%) and (E)-lachnophyllum ester (1.7%). (Z)-Lachnophyllum ester exhibited cytotoxic activity against MDA-MD-231, MCF-7, and 5637 human tumor cells, as well as antibacterial and antifungal activity.
authors.forename: Prabodh
authors.initials: P
authors.lastname: Satyal
authors.forename: Bhuwan K
authors.initials: BK
authors.lastname: Chhetri
authors.forename: Noura S
authors.initials: NS
authors.lastname: Dosoky
authors.forename: Samon
authors.initials: S
authors.lastname: Shrestha
authors.forename: Ambika
authors.initials: A
authors.lastname: Poudel
authors.forename: William N
authors.initials: WN
authors.lastname: Setzer
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D051379:Mice; D015394:Molecular Structure; D009390:Nepal; D009822:Oils, Volatile / Q000737:chemistry*; D035261:Plant Components, Aerial; D010938:Plant Oils / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile; D010938:Plant Oils; C000604534:lachnophyllum ester