title: Incidence and outcomes for adults diagnosed with acute myeloid leukemia in the north of England: a real world study.
abstract: We conducted a retrospective population-based study of patients diagnosed with acute myeloid leukemia (AML) in northern England (population 3.1 million) in order to assess the impact of age and genetics on outcome. Four hundred and sixteen patients were diagnosed with AML, between 2007 and 2011. In those aged ≤60 years (n = 20) with acute promyelocytic leukemia (APL) overall survival (OS) was 100%. For non-APL patients aged ≤60 years, OS for those with favorable, intermediate and adverse cytogenetics was not reached, 17 and 9.8 months, respectively (p = 0.0001). Of particular note, intensively treated patients aged >60 years with intermediate cytogenetics and FLT3-/NPM1+ status had a five-year survival of 60% versus median OS of 11 months for other subsets (p = 0.04). Population-based studies reduce selection bias and have utility in studying rarer diseases, particularly in populations that recruit poorly to trials. The highly favorable outcome in our subgroup of intensively-treated FLT3-/NPM1+ older patients merits further study.
authors.affiliation: a Department of Hematology , The Newcastle Upon Tyne Hospitals NHS Foundation Trust , Newcastle upon Tyne , UK ;
authors.forename: Andrew Kenneth
authors.initials: AK
authors.lastname: McGregor
authors.affiliation: a Department of Hematology , The Newcastle Upon Tyne Hospitals NHS Foundation Trust , Newcastle upon Tyne , UK ;
authors.forename: Deborah
authors.initials: D
authors.lastname: Moulton
authors.affiliation: b Northern Genetics Service, The Newcastle upon Tyne Hospitals NHS Foundation Trust , Newcastle upon Tyne , UK ;
authors.forename: Nick
authors.initials: N
authors.lastname: Bown
authors.affiliation: b Northern Genetics Service, The Newcastle upon Tyne Hospitals NHS Foundation Trust , Newcastle upon Tyne , UK ;
authors.forename: Gavin
authors.initials: G
authors.lastname: Cuthbert
authors.affiliation: b Northern Genetics Service, The Newcastle upon Tyne Hospitals NHS Foundation Trust , Newcastle upon Tyne , UK ;
authors.forename: David
authors.initials: D
authors.lastname: Bourn
authors.affiliation: c Department of Hematology , City Hospitals Sunderland NHS Foundation Trust , Sunderland, UK ;
authors.forename: Susanna
authors.initials: S
authors.lastname: Mathew
authors.affiliation: d Department of Hematology , South Tees Hospitals NHS Foundation Trust , Middlesbrough , UK ;
authors.forename: Raymond
authors.initials: R
authors.lastname: Dang
authors.affiliation: e Department of Hematology , North Tees and Hartlepool NHS Foundation Trust , Stockton , UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Mounter
authors.affiliation: a Department of Hematology , The Newcastle Upon Tyne Hospitals NHS Foundation Trust , Newcastle upon Tyne , UK ;
authors.forename: Gail
authors.initials: G
authors.lastname: Jones
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D003131:Combined Modality Therapy; D004739:England / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009154:Mutation; D000090243:Nucleophosmin; D017063:Outcome Assessment, Health Care; D011159:Population Surveillance; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
keywords: Acute myeloid leukemia; FLT3; NPM1; cytogenetics; epidemiology