title: Digit-Sparing Mohs Surgery for Melanoma.
abstract: BACKGROUND
  Digital melanoma is commonly treated with amputation or wide local excision. Mohs micrographic surgery (MMS) may offer an alternative treatment modality.
  
  
  OBJECTIVE
  To describe outcomes of digital melanomas treated with MMS over a 35-year period.
  
  
  METHODS
  A retrospective series of digital melanomas treated with MMS was studied. Tumor and treatment characteristics were described and follow-up was assessed.
  
  
  RESULTS
  Sixty-two digital (1.2%) tumors were identified from 4995 melanomas, of which 57 (91.9%) were primary and 5 (8.1%) were recurrent on enrollment. Melanocytic antigen recognized by cytotoxic T lymphocytes from melanoma patients (MART)-1 and HMB-45 immunostains were used in 34 (54.8%) and 14 (22.6%) cases, respectively. Five (8.2%) tumors recurred locally during the course of the study, none of which occurred with MART-1 use. Three (60.0%) local recurrences were salvaged with additional MMS. Local recurrence-free survival rates for primary melanomas at 5 and 10 years were 91.8% and 82.6%, respectively. Overall, 55 (96.5%) patients with primary digital melanomas avoided amputation. Five and 10-year melanoma-specific survival rates for all patients were 95.0% and 81.2%, respectively.
  
  
  CONCLUSIONS
  A formal comparison group was not studied.
  
  
  CONCLUSIONS
  In the management of digital melanoma, MMS conserves function by avoiding amputation and offers a low local recurrence rate. Outcomes are improved with the use of MART-1.
authors.affiliation: *Zitelli and Brodland Skin Cancer Center, Pittsburgh, Pennsylvania; †Adolos Strategic, San Antonio, Texas.
authors.forename: Vitaly
authors.initials: V
authors.lastname: Terushkin
authors.forename: David G
authors.initials: DG
authors.lastname: Brodland
authors.forename: Danny J
authors.initials: DJ
authors.lastname: Sharon
authors.forename: John A
authors.initials: JA
authors.lastname: Zitelli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D005385:Fingers / Q000601:surgery*; D006801:Humans; D058965:MART-1 Antigen / Q000032:analysis; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D015580:Mohs Surgery; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000601:surgery; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D058965:MART-1 Antigen