title: Topical Anti-Inflammatory Activity of Oil from Tropidurus hispidus (Spix, 1825).
abstract: Tropidurus hispidus has been used in traditional medicine in several regions of Northeastern Region of Brazil. Its medicinal use involves the treatment of diseases such as warts, sore throat, tonsillitis, chicken pox, varicella, measles, asthma, alcoholism, and dermatomycosis. The present study evaluated the topical anti-inflammatory activity of Tropidurus hispidus fat in treating ear edema in an animal model. Oil from T. hispidus (OTH) was evaluated on its effect against experimental inflammation in mice. OTH was extracted from body fat located in the ventral region of Tropidurus hispidus using hexane as a solvent. We used the model of mouse ear edema induced by phlogistic agents, croton oil (single and multiple applications), arachidonic acid, phenol, capsaicin, and histamine, applied into the right ears of animals pretreated with acetone (control), dexamethasone, or OTH. OTH inhibited the dermatitis induced by all noxious agents, except capsaicin. This effect may be related to the fatty acids present in OTH.
authors.affiliation: Laboratory of Zoology, Regional University of Cariri (URCA), Pimenta, 63105-000 Crato, CE, Brazil.
authors.forename: Israel J M
authors.initials: IJ
authors.lastname: Santos
authors.affiliation: Program of Post-Graduation in Pharmacology, Federal University of Santa Maria, Campus Camobi, 97105-900 Santa Maria, RS, Brazil.
authors.forename: Gerlânia O
authors.initials: GO
authors.lastname: Leite
authors.affiliation: Laboratory of Natural Products Research, Regional University of Cariri (URCA), Pimenta, 63105-000 Crato, CE, Brazil.
authors.forename: José Galberto M
authors.initials: JG
authors.lastname: Costa
authors.affiliation: Department of Biology, Paraiba State University (UEPB), 58429-500 João Pessoa, PB, Brazil ; Programa de Pós Graduação em Etnobiologia e Conservação da Natureza, Departamento de Ciências Biológicas, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros s/n, Dois Irmãos, 52171-900 Recife, PE, Brazil.
authors.forename: Romulo R N
authors.initials: RR
authors.lastname: Alves
authors.affiliation: Universidade de Fortaleza, Avenida Washington Soares 1321, 60811-905 Fortaleza, CE, Brazil.
authors.forename: Adriana R
authors.initials: AR
authors.lastname: Campos
authors.affiliation: Laboratory of Pharmacology and Medicinal Chemistry, Regional University of Cariri (URCA), Pimenta, 63105-000 Crato, CE, Brazil.
authors.forename: Irwin R A
authors.initials: IR
authors.lastname: Menezes
authors.affiliation: Laboratory of Carcinology, Regional University of Cariri (URCA), Pimenta, 63105-000 Crato, CE, Brazil.
authors.forename: Francisco Ronaldo V
authors.initials: FR
authors.lastname: Freita
authors.affiliation: Department of Nursing, Regional University of Cariri, 63105-000 Crato, CE, Brazil.
authors.forename: Maria Janeth H
authors.initials: MJ
authors.lastname: Nunes
authors.affiliation: Laboratory of Zoology, Regional University of Cariri (URCA), Pimenta, 63105-000 Crato, CE, Brazil.
authors.forename: Waltécio O
authors.initials: WO
authors.lastname: Almeida