title: Original footage of the Chilean miners with manganism published in Neurology in 1967.
abstract: Manganism has captured the imagination of neurologists for more than a century because of its similarities to Parkinson disease and its indirect but seminal role in the "l-dopa miracle." We present unpublished footage of the original case series reported in Neurology® in 1967 by Mena and Cotzias depicting the typical neurologic signs of manganism in 4 Chilean miners and their response to high doses of l-dopa.
authors.affiliation: From the Departments of Neurology (M.M.) and Radiology (F.M.), Clinica Las Condes; the Program of Human Genetics, Biomedical Sciences Institute, and Department of Psychiatry and Mental Health, North Division, Faculty of Medicine (M.L.B.), and Biomedical Neurosciences Institute, Faculty of Medicine (M.L.B.), Universidad de Chile, Santiago; and Reta Lila Weston Institute of Neurological Sciences (A.L.), Institute of Neurology, University College London, UK. marcelomirandac@gmail.com.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Miranda
authors.affiliation: From the Departments of Neurology (M.M.) and Radiology (F.M.), Clinica Las Condes; the Program of Human Genetics, Biomedical Sciences Institute, and Department of Psychiatry and Mental Health, North Division, Faculty of Medicine (M.L.B.), and Biomedical Neurosciences Institute, Faculty of Medicine (M.L.B.), Universidad de Chile, Santiago; and Reta Lila Weston Institute of Neurological Sciences (A.L.), Institute of Neurology, University College London, UK.
authors.forename: M Leonor
authors.initials: ML
authors.lastname: Bustamante
authors.affiliation: From the Departments of Neurology (M.M.) and Radiology (F.M.), Clinica Las Condes; the Program of Human Genetics, Biomedical Sciences Institute, and Department of Psychiatry and Mental Health, North Division, Faculty of Medicine (M.L.B.), and Biomedical Neurosciences Institute, Faculty of Medicine (M.L.B.), Universidad de Chile, Santiago; and Reta Lila Weston Institute of Neurological Sciences (A.L.), Institute of Neurology, University College London, UK.
authors.forename: Francisco
authors.initials: F
authors.lastname: Mena
authors.affiliation: From the Departments of Neurology (M.M.) and Radiology (F.M.), Clinica Las Condes; the Program of Human Genetics, Biomedical Sciences Institute, and Department of Psychiatry and Mental Health, North Division, Faculty of Medicine (M.L.B.), and Biomedical Neurosciences Institute, Faculty of Medicine (M.L.B.), Universidad de Chile, Santiago; and Reta Lila Weston Institute of Neurological Sciences (A.L.), Institute of Neurology, University College London, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Lees
mesh_terms: D002677:Chile; D049673:History, 20th Century; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D020149:Manganese Poisoning / Q000175:diagnosis / Q000188:drug therapy / Q000266:history*; D000067572:Miners / Q000266:history*; D009462:Neurology / Q000266:history*; D016273:Occupational Exposure / Q000266:history*
chemical_list: D007980:Levodopa