title: Carcinoembryonic antigen-related cell adhesion molecule 1 is expressed and as a function histotype in ovarian tumors.
abstract: Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a cell-cell adhesion receptor and is implicated in several cellular functions. It is rarely reported in ovarian tumors. The aim of this study is to determine the expression of CEACAM1 in ovarian tumors, trying to see whether CEACAM1 has different expression patterns as a function of histotype. Antigen expression was examined by immunohistochemistry with mouse anti-human antibody for CEACAM1. Immunohistochemistry was performed using avidin-biotin-diaminobenzide staining. The results were expressed as average score ± SD (0, negative; 8, highest) for each histotype. In ovarian tumors, the benign serous and mucinous cystadenoma negatively or weakly expressed CEACAM1, the malignant epithelial tumors strongly expressed CEACAM1, and there was significant difference between benign epithelial tumor and adenocarcinoma (P < .05). The well-differentiated serous adenocarcinoma expressed CEACAM1 mainly with membrane pattern, and the intermediately and poorly differentiated serous adenocarcinomas expressed CEACAM1 mainly with cytoplasmic pattern (P < .05). In addition, CEACAM1 expression is elevated in solid tumors of ovary but variable as a function of histotype. Compared with membranous expression, the cytoplasmic expression was observed almost in metastatic carcinoma that might decrease the adhesive interactions of the carcinoma cells with the surrounding cells, especially with tumor cells, and this could facilitate the tumor cells to metastasize to distant regions. So, we thought that cytoplasmic CEACAM1 might play an important role in tumor progression, especially in tumor metastasis.
authors.affiliation: Department of Anatomy, College of Basic Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355 Shandong, PR China. Electronic address: mary9li@163.com.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Pathology, The Second Hospital, Shandong University, Jinan, Shandong 250033, PR China. Electronic address: jingyanyang0216@163.com.
authors.forename: Jing-Yan
authors.initials: JY
authors.lastname: Yang
authors.affiliation: Department of Pathology, The Second Hospital, Shandong University, Jinan, Shandong 250033, PR China. Electronic address: xiaoyingwang@126.com.
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Wang
authors.affiliation: Department of Pathology, The Second Hospital, Shandong University, Jinan, Shandong 250033, PR China. Electronic address: haitaowang@163.com.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Wang
authors.affiliation: Department of Pathology, The Second Hospital, Shandong University, Jinan, Shandong 250033, PR China. Electronic address: gbx1986@163.com.
authors.forename: Bing-Xin
authors.initials: BX
authors.lastname: Guan
authors.affiliation: Department of Pathology, The Second Hospital, Shandong University, Jinan, Shandong 250033, PR China. Electronic address: chengjunzhou@sdu.edu.cn.
authors.forename: Cheng-Jun
authors.initials: CJ
authors.lastname: Zhou
mesh_terms: D015703:Antigens, CD / Q000032:analysis / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000473:pathology*
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C069847:CD66 antigens; D015815:Cell Adhesion Molecules
keywords: CEACAM1; IHC; Ovarian tumor