title: Foldameric probes for membrane interactions by induced β-sheet folding.
abstract: Design strategies were devised for α/β-peptide foldameric analogues of the antiangiogenic anginex with the goal of mimicking the diverse structural features from the unordered conformation to a folded β-sheet in response to membrane interactions. Structure-activity relationships were investigated in the light of different β-sheet folding levels.
authors.affiliation: Institute of Pharmaceutical Analysis, SZTE-MTA Lendület Foldamer Research Group, University of Szeged, H-6720 Szeged, Hungary. martinek@pharm.u-szeged.hu.
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Hegedüs
authors.affiliation: Lymphocyte Signal Transduction Laboratory, Institute of Genetics, Biological Research Centre of the Hungarian Academy of Sciences, H-6726 Szeged, Hungary.
authors.forename: Ildikó
authors.initials: I
authors.lastname: Makra
authors.affiliation: Institute of Pharmaceutical Analysis, SZTE-MTA Lendület Foldamer Research Group, University of Szeged, H-6720 Szeged, Hungary. martinek@pharm.u-szeged.hu.
authors.forename: Norbert
authors.initials: N
authors.lastname: Imre
authors.affiliation: Department of Medical Chemistry, University of Szeged, H-6720 Szeged, Hungary.
authors.forename: Anasztázia
authors.initials: A
authors.lastname: Hetényi
authors.affiliation: Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Hungary.
authors.forename: István M
authors.initials: IM
authors.lastname: Mándity
authors.affiliation: Lymphocyte Signal Transduction Laboratory, Institute of Genetics, Biological Research Centre of the Hungarian Academy of Sciences, H-6726 Szeged, Hungary.
authors.forename: Éva
authors.initials: É
authors.lastname: Monostori
authors.affiliation: Institute of Pharmaceutical Analysis, SZTE-MTA Lendület Foldamer Research Group, University of Szeged, H-6720 Szeged, Hungary. martinek@pharm.u-szeged.hu.
authors.forename: Tamás A
authors.initials: TA
authors.lastname: Martinek
mesh_terms: D002942:Circular Dichroism; D008567:Membranes, Artificial; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D017510:Protein Folding; D066244:Proton Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship
chemical_list: D008567:Membranes, Artificial; D010455:Peptides