title: Can Psychological, Social and Demographical Factors Predict Clinical Characteristics Symptomatology of Bipolar Affective Disorder and Schizophrenia?
abstract: Schizophrenia (SCH) is a complex, psychiatric disorder affecting 1 % of population. Its clinical phenotype is heterogeneous with delusions, hallucinations, depression, disorganized behaviour and negative symptoms. Bipolar affective disorder (BD) refers to periodic changes in mood and activity from depression to mania. It affects 0.5-1.5 % of population. Two types of disorder (type I and type II) are distinguished by severity of mania episodes. In our analysis, we aimed to check if clinical and demographical characteristics of the sample are predictors of symptom dimensions occurrence in BD and SCH cases. We included total sample of 443 bipolar and 439 schizophrenia patients. Diagnosis was based on DSM-IV criteria using Structured Clinical Interview for DSM-IV. We applied regression models to analyse associations between clinical and demographical traits from OPCRIT and symptom dimensions. We used previously computed dimensions of schizophrenia and bipolar affective disorder as quantitative traits for regression models. Male gender seemed protective factor for depression dimension in schizophrenia and bipolar disorder sample. Presence of definite psychosocial stressor prior disease seemed risk factor for depressive and suicidal domain in BD and SCH. OPCRIT items describing premorbid functioning seemed related with depression, positive and disorganised dimensions in schizophrenia and psychotic in BD. We proved clinical and demographical characteristics of the sample are predictors of symptom dimensions of schizophrenia and bipolar disorder. We also saw relation between clinical dimensions and course of disorder and impairment during disorder.
authors.affiliation: Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Rokietnicka St. 8, 60-806, Poznan, Poland.|Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.|Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Maciukiewicz
authors.affiliation: Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Rokietnicka St. 8, 60-806, Poznan, Poland. joanna.pawlak@gmail.com.
authors.forename: Joanna
authors.initials: J
authors.lastname: Pawlak
authors.affiliation: Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Rokietnicka St. 8, 60-806, Poznan, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Kapelski
authors.affiliation: Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Rokietnicka St. 8, 60-806, Poznan, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Łabędzka
authors.affiliation: Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Rokietnicka St. 8, 60-806, Poznan, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Skibinska
authors.affiliation: Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Rokietnicka St. 8, 60-806, Poznan, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Zaremba
authors.affiliation: Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Rokietnicka St. 8, 60-806, Poznan, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Leszczynska-Rodziewicz
authors.affiliation: Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Rokietnicka St. 8, 60-806, Poznan, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Dmitrzak-Weglarz
authors.affiliation: Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Rokietnicka St. 8, 60-806, Poznan, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Hauser
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001714:Bipolar Disorder / Q000523:psychology*; D002648:Child; D002675:Child, Preschool; D003863:Depression / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D012044:Regression Analysis; D012559:Schizophrenia; D012565:Schizophrenic Psychology; D012737:Sex Factors; D013315:Stress, Psychological / Q000523:psychology*; D059020:Suicidal Ideation; D055815:Young Adult
keywords: Bipolar affective disorder; Dimensions; OPCRIT; Schizophrenia