title: Emergence of OXA-162 Carbapenemase- and DHA-1 AmpC Cephalosporinase-Producing Sequence Type 11 Klebsiella pneumoniae Causing Community-Onset Infection in Greece.
abstract: OXA-48-like carbapenemases have only recently emerged in Europe. OXA-162 is a rare OXA-48 variant usually coexpressed with extended-spectrum β-lactamases. Here, we report the identification of the first OXA-162 carbapenemase-producing Klebsiella pneumoniae isolates, which coexpressed an AmpC cephalosporinase (DHA-1), retrieved from a patient in Greece. They belonged to a single sequence type (ST11) and caused the first documented community-onset urinary tract infections attributable to an OXA-48-like-producing Enterobacteriaceae strain.
authors.affiliation: Department of Microbiology, Medical School, University of Athens, Athens, Greece.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Voulgari
authors.affiliation: Department of Microbiology, Medical School, University of Athens, Athens, Greece Department of Microbiology, Serres General Hospital, Serres, Greece.
authors.forename: Aggeliki
authors.initials: A
authors.lastname: Poulou
authors.affiliation: Department of Microbiology, Medical School, University of Athens, Athens, Greece.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Dimitroulia
authors.affiliation: Department of Microbiology, Medical School, University of Athens, Athens, Greece.
authors.forename: Lida
authors.initials: L
authors.lastname: Politi
authors.affiliation: Department of Microbiology, Medical School, University of Athens, Athens, Greece.
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Ranellou
authors.affiliation: Department of Microbiology, Medical School, University of Athens, Athens, Greece.
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Gennimata
authors.affiliation: Department of Microbiology, Serres General Hospital, Serres, Greece.
authors.forename: Fani
authors.initials: F
authors.lastname: Markou
authors.affiliation: Department of Microbiology, Medical School, University of Athens, Athens, Greece.
authors.forename: Spyros
authors.initials: S
authors.lastname: Pournaras
authors.affiliation: Department of Microbiology, Medical School, University of Athens, Athens, Greece atsakris@med.uoa.gr.
authors.forename: Athanassios
authors.initials: A
authors.lastname: Tsakris
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D002510:Cephalosporinase / Q000235:genetics*; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D005260:Female; D006115:Greece; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D058885:Multilocus Sequence Typing; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002510:Cephalosporinase; C048795:AmpC beta-lactamases; D001618:beta-Lactamases; C000601045:beta-lactamase DHA-1, Klebsiella pneumoniae; C063912:carbapenemase; C108449:oxacillinase