title: Simultaneous detection of single-nucleotide polymorphisms in a DNA bulge structure using a fluorine-modified bisbenzimide derivative.
abstract: Using 3,5-bis(trifluoromethyl)benzene-modified bisbenzimide H33258, bulged-out nucleobases on a DNA strand can be detected by the chemical shift change in (19)F NMR. Based on this technique, single-nucleotide polymorphisms on a DNA sequence can be analyzed simultaneously.
authors.affiliation: School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahi-dai, Nomi, Ishikawa 923-1292, Japan. tsakamo@jaist.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakamoto
authors.affiliation: School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahi-dai, Nomi, Ishikawa 923-1292, Japan. tsakamo@jaist.ac.jp.
authors.forename: Daisaku
authors.initials: D
authors.lastname: Hasegawa
authors.affiliation: School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahi-dai, Nomi, Ishikawa 923-1292, Japan. tsakamo@jaist.ac.jp.
authors.forename: Kenzo
authors.initials: K
authors.lastname: Fujimoto
mesh_terms: D001483:Base Sequence; D006690:Bisbenzimidazole / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000235:genetics*; D005240:Feasibility Studies; D005461:Fluorine / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D020641:Polymorphism, Single Nucleotide; D013997:Time Factors
chemical_list: D005461:Fluorine; D004247:DNA; D006690:Bisbenzimidazole