title: [Pathophysiology of type 2 diabetes mellitus].
abstract: The development of type 2 diabetes is usually associated with a combination of pancreatic β-cell dysfunction and insulin resistance in various insulin target tissues such as the liver, muscle and adipocytes. Normal β-cells can compensate for insulin resistance by increasing insulin secretion or β-cell mass, but insufficient compensation leads to the onset of glucose intolerance. Once hyperglycemia becomes apparent, β-cell function gradually deteriorates and insulin resistance aggravates. This process is called "glucose toxicity".
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneto
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D018149:Glucose Intolerance / Q000150:complications; D006801:Humans; D050356:Lipid Metabolism