title: Meta-analysis of downregulated E-cadherin as a poor prognostic biomarker for cervical cancer.
abstract: OBJECTIVE
  This meta-analysis was conducted to evaluate the diagnostic and prognostic functions of E-cadherin expression in cervical cancer.
  
  
  METHODS
  PubMed and other databases were searched for articles associated with E-cadherin and cervical cancer. These articles were published before June 2015 and written in English or Chinese. Random-effects model was used to pool odds ratios on the heterogeneity test in the meta-analysis.
  
  
  RESULTS
  All of 20 studies were analyzed, in which 522 (42.6%) subjects exhibited reduced E-cadherin expression. Evaluation of clinicopathologic features showed that the downregulation of E-cadherin was related to the overall survival, clinicopathological parameters and age.
  
  
  CONCLUSIONS
  Downregulation of E-cadherin in cervical cancer patients showed poor overall survival. Therefore, E-cadherinmay be a metastasis-suppressor gene in cervical cancer.
authors.affiliation: Department of Pathology, Shihezi University School of Medicine & the Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.
authors.forename: Jifeng
authors.initials: J
authors.lastname: Peng
authors.affiliation: Department of Pathology, Shihezi University School of Medicine & the Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Qi
authors.affiliation: Department of Pathology, Shihezi University School of Medicine & the Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Pathology, Shihezi University School of Medicine & the Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.
authors.forename: Wanyu
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Pathology, Shihezi University School of Medicine & the Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.
authors.forename: Lingxie
authors.initials: L
authors.lastname: Song
authors.affiliation: Department of Pathology, Shihezi University School of Medicine & the Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.|Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Pathology, Shihezi University School of Medicine & the Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Chinese Ministry of Education, Shihezi, Xinjiang 832002, China.|Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
mesh_terms: D015415:Biomarkers; D015820:Cadherins / Q000235:genetics*; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009367:Neoplasm Staging; D016017:Odds Ratio; D011379:Prognosis; D017594:Publication Bias; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology
chemical_list: D015415:Biomarkers; D015820:Cadherins
keywords: E-cadherin; biomarker; cervical cancer; meta-analysis; prognosis