title: Incorporating Informatics for Integrating Biology and the Bedside (i2b2) into Predoctoral Trainee Curriculum to Evaluate Student-Generated Hypotheses.
abstract: As part of the Clinical and Translational Science Institute predoctoral TL1 training program at the Pennsylvania State University, a multidisciplinary team of predoctoral trainees representing the Chemistry, Neurosurgery, Nutritional Sciences, and Public Health Sciences departments were introduced to the NIH-sponsored Informatics for Integrating Biology and the Bedside (i2b2) database to test the following student-generated hypothesis: children with iron deficiency anemia (IDA) are at increased risk of attention deficit-hyperactivity disorder (ADHD). Children aged 4-12 and 4-17 years were categorized into IDA and control groups. De-identified medical records from the Penn State Milton S. Hershey Medical Center (HMC) and the Virginia Commonwealth University Medical Center (VCUMC) were used for the analysis. Overall, ADHD prevalence at each institution was lower than 2011 state estimates. There was a significant association between IDA and ADHD in the 4-17-year-old age group for all children (OR: 1.902 [95% CI: 1.363-2.656]), Caucasian children (OR: 1.802 [95% CI: 1.133-2.864]), and African American children (OR: 1.865 [95% CI: 1.152-3.021]). Clinical and Translational Science Award (CTSA) infrastructure is particularly useful for trainees to answer de novo scientific questions with minimal additional training and technical expertise. Moreover, projects can be expanded by collaborating within the CTSA network.
authors.affiliation: TL1 Training Program, Penn State Clinical and Translational Sciences Institute, Hershey, Pennsylvania, USA.|Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Schieffer
authors.affiliation: TL1 Training Program, Penn State Clinical and Translational Sciences Institute, Hershey, Pennsylvania, USA.|Department of Neuroscience, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Peters
authors.affiliation: TL1 Training Program, Penn State Clinical and Translational Sciences Institute, Hershey, Pennsylvania, USA.|Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
authors.forename: Chesney K
authors.initials: CK
authors.lastname: Richter
authors.affiliation: TL1 Training Program, Penn State Clinical and Translational Sciences Institute, Hershey, Pennsylvania, USA.|Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania, USA.
authors.forename: Welley S
authors.initials: WS
authors.lastname: Loc
authors.affiliation: Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania, USA.
authors.forename: James A
authors.initials: JA
authors.lastname: Pawelczyk
mesh_terms: D000293:Adolescent; D018798:Anemia, Iron-Deficiency / Q000150:complications*; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D003479:Curriculum; D057286:Electronic Health Records; D005260:Female; D006801:Humans; D008297:Male; D008490:Medical Informatics / Q000379:methods; D009316:National Institutes of Health (U.S.); D010414:Pennsylvania; D015995:Prevalence; D012107:Research Design; D018426:SEER Program; D013337:Students, Medical; D057170:Translational Research, Biomedical / Q000193:education* / Q000379:methods*; D014481:United States; D014768:Virginia
keywords: anemia-nutritional; attention-deficit/hyperactivity disorder; bioinformatics; cobalamin; folate < anemia; iron; medical records; predoctoral