title: A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines.
abstract: An efficient one-pot synthesis of pyrazolo[3,4-d]pyrimidine derivatives by the four-component condensation of hydrazines, methylenemalononitriles, aldehydes and alcohols has been developed via two different reaction pathways. The structures of target products were characterized by IR spectroscopy, NMR ((1)H and (13)C) spectroscopy and HRMS (ESI) spectrometry. The crystal structure of 4-ethoxy-6-(2-nitrophenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine was determined by single crystal X-ray diffraction.
authors.affiliation: School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing, 100081, China.
authors.forename: Mingxing
authors.initials: M
authors.lastname: Liu
authors.affiliation: School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing, 100081, China.
authors.forename: Jiarong
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing, 100081, China.
authors.forename: Hongxin
authors.initials: H
authors.lastname: Chai
authors.affiliation: School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing, 100081, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.affiliation: School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing, 100081, China.
authors.forename: Deli
authors.initials: D
authors.lastname: Yang
authors.affiliation: School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing, 100081, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing, 100081, China.
authors.forename: Daxin
authors.initials: D
authors.lastname: Shi
keywords: four-component; one-pot; pyrazolo[3,4-d]pyrimidine; sodium alkoxide