title: Host-guest system of hesperetin and β-cyclodextrin or its derivatives: Preparation, characterization, inclusion mode, solubilization and stability.
abstract: The inclusion complexation behavior, characterization and binding ability of hesperetin with β-cyclodextrin and its derivatives were investigated in both the solution and solid state by means of XRD, DSC, SEM, (1)H and 2D NMR and UV-vis spectroscopy. The results showed that the water solubility and stability of hesperetin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high stability of the hesperetin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products.
authors.affiliation: School of Chemistry & Environment, Engineering Research Center of Biopolymer Functional Materials of Yunnan, Yunnan Minzu University, Kunming 650500, PR China. Electronic address: yangljyang@sina.com.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Yang
authors.affiliation: School of Chemistry & Environment, Engineering Research Center of Biopolymer Functional Materials of Yunnan, Yunnan Minzu University, Kunming 650500, PR China.
authors.forename: Sha
authors.initials: S
authors.lastname: Xia
authors.affiliation: School of Chemistry & Environment, Engineering Research Center of Biopolymer Functional Materials of Yunnan, Yunnan Minzu University, Kunming 650500, PR China.
authors.forename: Shui-Xian
authors.initials: SX
authors.lastname: Ma
authors.affiliation: School of Chemistry & Environment, Engineering Research Center of Biopolymer Functional Materials of Yunnan, Yunnan Minzu University, Kunming 650500, PR China.
authors.forename: Shu-Ya
authors.initials: SY
authors.lastname: Zhou
authors.affiliation: School of Chemistry & Environment, Engineering Research Center of Biopolymer Functional Materials of Yunnan, Yunnan Minzu University, Kunming 650500, PR China.
authors.forename: Xue-Qiu
authors.initials: XQ
authors.lastname: Zhao
authors.affiliation: School of Chemistry & Environment, Engineering Research Center of Biopolymer Functional Materials of Yunnan, Yunnan Minzu University, Kunming 650500, PR China.
authors.forename: Shu-Hui
authors.initials: SH
authors.lastname: Wang
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323, United States.
authors.forename: Min-Yan
authors.initials: MY
authors.lastname: Li
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China. Electronic address: xdyang@ynu.edu.cn.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Yang
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D004355:Drug Stability; D006569:Hesperidin / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D012995:Solubility
chemical_list: D003505:Cyclodextrins; D006569:Hesperidin; C013015:hesperetin
keywords: Binding behaviors; Cyclodextrin; Hesperetin; Solubilization; Stability