title: Myocardial (123)I-MIBG Uptake and Cardiovascular Autonomic Function in Parkinson's Disease.
abstract: Introduction. Patients with Parkinson's disease (PD) showed reduced myocardial (123)I-MIBG uptake, which may affect autonomic regulation. We investigated correlation between MIBC accumulation and cardiovascular autonomic function in PD. Methods. We performed myocardial MIBG scintigraphy, heart rate variability (HRV) analysis, and the head-up tilt test (HUT) in 50 PD patients (66.4 ± 7.8 years; duration 5.5 ± 5.9 years). Autonomic function tests were also performed in 50 healthy controls (66.5 ± 8.9 years). As HRV parameters, a high-frequency power (HF, 0.15-0.4 Hz), a low-frequency power (LF, 0.04-0.15 Hz), and LF/HF ratio were used. Results. Our PD patients had a significant reduction in LF and HF compared with the controls (P = 0.005 and P = 0.01). In HUT, systolic and diastolic blood pressure falls in the PD group were significantly greater than those in the controls (P = 0.02 and P = 0.02). The washout rate of MIBG was negatively correlated with blood pressure changes during HUT. Conclusion. Our PD patients showed reduced HRV, blood pressure dysregulation, and reduced MIBG accumulation, which was correlated with blood pressure dysregulation. Orthostatic hypotension in PD may be mainly caused by sympathetic postganglionic degeneration.
authors.affiliation: Department of Neurology, Chiba University School of Medicine, Chiba 260-8670, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Katagiri
authors.affiliation: Department of Neurology, Chiba University School of Medicine, Chiba 260-8670, Japan ; Department of General Medical Science, Chiba University School of Medicine, Chiba 260-8670, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Asahina
authors.affiliation: Department of Neurology, Chiba University School of Medicine, Chiba 260-8670, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Araki
authors.affiliation: Department of Neurology, Chiba University School of Medicine, Chiba 260-8670, Japan.
authors.forename: Anupama
authors.initials: A
authors.lastname: Poudel
authors.affiliation: Department of Neurology, Chiba University School of Medicine, Chiba 260-8670, Japan.
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Fujinuma
authors.affiliation: Department of Neurology, Chiba University School of Medicine, Chiba 260-8670, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Yamanaka
authors.affiliation: Department of Neurology, Chiba University School of Medicine, Chiba 260-8670, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara