title: Evaluating the clinical significances of serum HE4 with CA125 in peritoneal tuberculosis and epithelial ovarian cancer.
abstract: This study aimed to evaluate the clinical significances of human epididymis protein 4 (HE4) with cancer antigen 125 (CA125) in differential diagnosis between epithelial ovarian cancer (EOC) and peritoneal tuberculosis (PTB). We retrospectively reviewed data of 31 patients suspected preoperatively as having EOC but whose pathological results revealed PTB. The concentrations of serum HE4 and CA125 in PTB were significantly lower than that in EOC. The optimal cutoffs to differentiate EOC from PTB were HE4 > 151.4 pmol/l and CA125 > 563.5 U/ml, which means EOC may be considered if HE4 or CA125 was greater than the cutoff, otherwise, PTB should not be neglected. Furthermore, the specificity and accuracy for differentiating PTB form EOC could be improved when combination HE4 and CA125. Conclusively, the combination of HE4 and CA125 may be recommended as potential biomarkers in the preliminary differential diagnosis of PTB from EOC before the "golden standard" of pathologic diagnosis finally obtained.
authors.affiliation: a Department of Gynecologic Oncology , Tianjin Medical University Cancer Institute and Hospital , Tianjin , China .|b Key Laboratory of Cancer Prevention and Therapy , Tianjin , China , and.|c National Clinical Research Centre of Cancer , Tianjin , China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: a Department of Gynecologic Oncology , Tianjin Medical University Cancer Institute and Hospital , Tianjin , China .|b Key Laboratory of Cancer Prevention and Therapy , Tianjin , China , and.|c National Clinical Research Centre of Cancer , Tianjin , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: a Department of Gynecologic Oncology , Tianjin Medical University Cancer Institute and Hospital , Tianjin , China .
authors.forename: Wenxin
authors.initials: W
authors.lastname: Liu
authors.affiliation: a Department of Gynecologic Oncology , Tianjin Medical University Cancer Institute and Hospital , Tianjin , China .
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D000077216:Carcinoma, Ovarian Epithelial; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood* / Q000175:diagnosis; D010051:Ovarian Neoplasms / Q000097:blood* / Q000175:diagnosis; D014395:Peritonitis, Tuberculous / Q000097:blood* / Q000175:diagnosis; D011506:Proteins / Q000032:analysis*; D012372:ROC Curve; D012189:Retrospective Studies; D000081102:WAP Four-Disulfide Core Domain Protein 2; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen; D011506:Proteins; D000081102:WAP Four-Disulfide Core Domain Protein 2; C569698:WFDC2 protein, human
keywords: Cancer antigen 125; human epididymis protein 4; ovarian cancer; peritoneal tuberculosis