title: Clinical characteristics of idiopathic normal pressure hydrocephalus with Lewy body diseases.
abstract: BACKGROUND
  Comorbidity of idiopathic normal pressure hydrocephalus and neurodegenerative diseases presents a diagnostic challenge. The aim of this study was to elucidate the clinical features of iNPH patients who are possibly comorbid with Lewy body diseases.
  
  
  METHODS
  In this study, we retrospectively analyzed the records of consecutive 127 patients with definite idiopathic normal pressure hydrocephalus. (123)I-Metaiodobenzylguanidine myocardial scintigraphy was undertaken to 21 patients with idiopathic normal pressure hydrocephalus because of suspicion for comorbid Lewy body diseases.
  
  
  RESULTS
  As a result, 7 of the 21 patients with idiopathic normal pressure hydrocephalus exhibited cardiac sympathetic abnormality. Idiopathic normal pressure hydrocephalus patients with cardiac sympathetic dysfunction had the constellation of clinical findings, such as younger onset, less severe urinary dysfunction, kinesie paradoxale, and cogwheel rigidity.
  
  
  CONCLUSIONS
  Our results suggested that comorbidity of idiopathic normal pressure hydrocephalus and Lewy body diseases are not rare condition and careful screening for potentially-curative surgery is important especially in atypical cases.
authors.affiliation: Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Diagnostic Radiology, Tohoku University Hospital, Sendai, Japan.
authors.forename: Hayato
authors.initials: H
authors.lastname: Odagiri
authors.affiliation: Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: t-baba@med.tohoku.ac.jp.
authors.forename: Toru
authors.initials: T
authors.lastname: Baba
authors.affiliation: Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Nishio
authors.affiliation: Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Iizuka
authors.affiliation: Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Narita
authors.affiliation: Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Matsuda
authors.affiliation: Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Etsuro
authors.initials: E
authors.lastname: Mori
mesh_terms: D019797:3-Iodobenzylguanidine / Q000493:pharmacokinetics; D000368:Aged; D000369:Aged, 80 and over; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000150:complications* / Q000000981:diagnostic imaging; D007456:Iodine Isotopes / Q000493:pharmacokinetics; D020961:Lewy Body Disease / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D055414:Myocardial Perfusion Imaging; D012189:Retrospective Studies
chemical_list: D004791:Enzyme Inhibitors; D007456:Iodine Isotopes; D019797:3-Iodobenzylguanidine
keywords: (123)I-MIBG myocardial scintigraphy; Comorbidity; Dementia with Lewy bodies; Idiopathic normal pressure hydrocephalus; Parkinson's disease