title: [Tissue-specific membrane effects of estrogen receptor alpha].
abstract: Estrogen receptors (ER) are used as therapeutic targets, either for contraception or for the hormonal replacement therapy in menopausal women, but also in physiopathology for breast cancer treatment. It is therefore important to understand the tissue-specificity of the actions of ERα to optimize the benefits/risks ratio in each tissue. Besides the conventional nuclear ERα acting as a transcription factor, many studies have demonstrated that ERα is also able to mediate extra nuclear signaling, enabling rapid actions of estrogen. Recently, new transgenic mouse models were used to study these effects, and allowed to genetically segregate membrane versus nuclear actions of a steroid hormone receptor, demonstrating their in vivo tissue-specific roles.
authors.affiliation: Inserm U1048-Université Paul Sabatier, I2MC, CHU Rangueil, 1, avenue Jean Poulhès, 31432 Toulouse, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Adlanmerini
authors.affiliation: Inserm U1048-Université Paul Sabatier, I2MC, CHU Rangueil, 1, avenue Jean Poulhès, 31432 Toulouse, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Fabre
authors.affiliation: Inserm U1048-Université Paul Sabatier, I2MC, CHU Rangueil, 1, avenue Jean Poulhès, 31432 Toulouse, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Boudou
authors.affiliation: Inserm U1048-Université Paul Sabatier, I2MC, CHU Rangueil, 1, avenue Jean Poulhès, 31432 Toulouse, France.
authors.forename: Élodie
authors.initials: É
authors.lastname: Riant
authors.affiliation: Inserm U1048-Université Paul Sabatier, I2MC, CHU Rangueil, 1, avenue Jean Poulhès, 31432 Toulouse, France.
authors.forename: Coralie
authors.initials: C
authors.lastname: Fontaine
authors.affiliation: Inserm U1048-Université Paul Sabatier, I2MC, CHU Rangueil, 1, avenue Jean Poulhès, 31432 Toulouse, France.
authors.forename: Henrik
authors.initials: H
authors.lastname: Laurell
authors.affiliation: Inserm U1048-Université Paul Sabatier, I2MC, CHU Rangueil, 1, avenue Jean Poulhès, 31432 Toulouse, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Gourdy
authors.affiliation: Inserm U1048-Université Paul Sabatier, I2MC, CHU Rangueil, 1, avenue Jean Poulhès, 31432 Toulouse, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Lenfant
authors.affiliation: Inserm U1048-Université Paul Sabatier, I2MC, CHU Rangueil, 1, avenue Jean Poulhès, 31432 Toulouse, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Arnal
mesh_terms: D000818:Animals; D047628:Estrogen Receptor alpha / Q000502:physiology*; D006801:Humans; D009928:Organ Specificity / Q000502:physiology
chemical_list: D047628:Estrogen Receptor alpha