title: A Parallelized Pumpless Artificial Placenta System Significantly Prolonged Survival Time in a Preterm Lamb Model.
abstract: An artificial placenta (AP) is an arterio-venous extracorporeal life support system that is connected to the fetal circulation via the umbilical vasculature. Previously, we published an article describing a pumpless AP system with a small priming volume. We subsequently developed a parallelized system, hypothesizing that the reduced circuit resistance conveyed by this modification would enable healthy fetal survival time to be prolonged. We conducted experiments using a premature lamb model to test this hypothesis. As a result, the fetal survival period was significantly prolonged (60.4 ± 3.8 vs. 18.2 ± 3.2 h, P < 0.01), and circuit resistance and minimal blood lactate levels were significantly lower in the parallel circuit group, compared with our previous single circuit group. Fetal physiological parameters remained stable until the conclusion of the experiments. In summary, parallelization of the AP system was associated with reduced circuit resistance and lactate levels and allowed preterm lamb fetuses to survive for a significantly longer period when compared with previous studies.
authors.affiliation: Center for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan.|School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, Australia.
authors.forename: Yuichiro
authors.identifier: http://orcid.org/0000-0002-6693-4119
authors.initials: Y
authors.lastname: Miura
authors.affiliation: Center for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsuda
authors.affiliation: Center for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan.
authors.forename: Haruo
authors.initials: H
authors.lastname: Usuda
authors.affiliation: Center for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan.
authors.forename: Shimpei
authors.initials: S
authors.lastname: Watanabe
authors.affiliation: Center for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan.
authors.forename: Ryuta
authors.initials: R
authors.lastname: Kitanishi
authors.affiliation: Center for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Saito
authors.affiliation: Center for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan.
authors.forename: Takushi
authors.initials: T
authors.lastname: Hanita
authors.affiliation: Department of Veterinary Pathology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D005260:Female; D011247:Pregnancy; D001187:Artificial Organs; D004195:Disease Models, Animal; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation; D005333:Fetus / Q000098:blood supply / Q000502:physiology; D010920:Placenta / Q000502:physiology; D012756:Sheep; D034561:Sheep, Domestic; D014470:Umbilical Cord / Q000098:blood supply; D000831:Animals, Newborn
keywords: Artificial placenta; Parallelized circuit; Preterm lamb model