title: Molecular-oxygen-promoted Cu-catalyzed oxidative direct amidation of nonactivated carboxylic acids with azoles.
abstract: A copper-catalyzed oxidative direct formation of amides from nonactivated carboxylic acids and azoles with dioxygen as an activating reagent is reported. The azole amides were produced in good to excellent yields with a broad substrate scope. The mechanistic studies reveal that oxygen plays an essential role in the success of the amidation reactions with copper peroxycarboxylate as the key intermediate. Transamidation occurs smoothly between azole amide and a variety of amines.
authors.affiliation: Institute of Next Generation Matter Transformation, College of Chemical Engineering at Huaqiao Univeristy, P. R. China.
authors.forename: Wen
authors.initials: W
authors.lastname: Ding
authors.affiliation: College of Materials Science at Huaqiao University, 668 Jimei Blvd, Xiamen, Fujian, 361021, P. R. China.
authors.forename: Shaoyu
authors.initials: S
authors.lastname: Mai
authors.affiliation: Institute of Next Generation Matter Transformation, College of Chemical Engineering at Huaqiao Univeristy, P. R. China ; Beijing National Laboratory for Molecular Sciences, Beijing, 100190, P. R. China.
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Song
keywords: Cu-catalyzed; amidation; azoles; molecular oxygen; transamidation