title: Inflammatory Myofibroblastic Tumor of the Lung: Two Progressing Pulmonary Nodules in a 25-Year-Old Adult With a Moraxella catharalis Infection.
abstract: Inflammatory myofibroblastic tumor of the lung is a rare pulmonary lesion of intermediate biologic potential. Approximately half of all inflammatory myofibroblastic tumors show a rearrangement of the anaplastic lymphoma kinase (ALK) gene locus with potentially aberrant kinase expression. We present a 25-year-old man with recurrent exertional hemoptysis and two progressing pulmonary nodules in the right lung shown by computed tomography. After an anterolateral thoracotomy, pathologic studies revealed an inflammatory myofibroblastic tumor with rearrangement in the ALK gene, although aberrant expression of the anaplastic lymphoma kinase was not detected. In preoperative bronchial washings Moraxella catharalis was found.
authors.affiliation: Department of General Thoracic Surgery, University Hospital of Zurich, Zurich, Switzerland. Electronic address: daniel.schweckendiek@uzh.ch.
authors.forename: Daniel
authors.initials: D
authors.lastname: Schweckendiek
authors.affiliation: Department of General Thoracic Surgery, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Inci
authors.affiliation: Department of General Thoracic Surgery, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: Didier
authors.initials: D
authors.lastname: Schneiter
authors.affiliation: Department of General Thoracic Surgery, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: Walter
authors.initials: W
authors.lastname: Weder
mesh_terms: D000328:Adult; D001999:Bronchoscopy; D003937:Diagnosis, Differential; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D008297:Male; D001936:Moraxella catarrhalis / Q000302:isolation & purification*; D045828:Moraxellaceae Infections / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology; D009379:Neoplasms, Muscle Tissue / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D011013:Pneumonectomy; D014057:Tomography, X-Ray Computed