title: Potential protective effect of a G>A SNP in the 3'UTR of HLA-A for Chlamydia trachomatis symptomatology and severity of infection.
abstract: The interindividual differences in response to Chlamydia trachomatis (CT) infections are for an important part based on the differences in our host genetic make-up. In the past, several genes and pathways have been identified and linked to protection against or risk for CT infection (i.e. susceptibility), and/or the severity of infection, with a major emphasis on the development of tubal pathology, one of the main causes of female infertility. In the current study, we analyzed in Dutch Caucasian women whether the carriage of HLA-A G>A SNP (rs1655900) was related to the susceptibility of CT infection in a STD cohort (n = 329) and to the severity of infection in a subfertility cohort (n = 482). We also investigated if this A-allele was linked to increase in severity of symptoms, from mild symptoms (lower genital infection) to lower abdominal pain (upper genital tract infection) to the most severe late complication of tubal pathology, including double-sided tubal pathology. We showed that the carriage of HLA-A SNP rs1655900 studied is not associated with the susceptibility to CT infection based on the data from the STD cohort, but might be protective to the development of late complications (p = 0.0349), especially tubal pathology could be relevant.
authors.affiliation: Institute for Public Health Genomics, Department of Genetics and Cell Biology, School for Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD, Maastricht, the Netherlands.
authors.forename: Marleen E
authors.initials: ME
authors.lastname: Jansen
authors.affiliation: Institute for Public Health Genomics, Department of Genetics and Cell Biology, School for Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD, Maastricht, the Netherlands Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, 1081 HV, Amsterdam, the Netherlands.
authors.forename: Ivan
authors.initials: I
authors.lastname: Branković
authors.affiliation: Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, 1081 HV, Amsterdam, the Netherlands.
authors.forename: Joke
authors.initials: J
authors.lastname: Spaargaren
authors.affiliation: Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, 1081 HV, Amsterdam, the Netherlands.
authors.forename: Sander
authors.initials: S
authors.lastname: Ouburg
authors.affiliation: Institute for Public Health Genomics, Department of Genetics and Cell Biology, School for Oncology and Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD, Maastricht, the Netherlands Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, 1081 HV, Amsterdam, the Netherlands samorretravel@yahoo.co.uk.
authors.forename: Servaas A
authors.initials: SA
authors.lastname: Morré
mesh_terms: D020413:3' Untranslated Regions; D000483:Alleles; D002690:Chlamydia Infections / Q000175:diagnosis* / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000276:immunology; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics* / Q000276:immunology; D054884:Host-Pathogen Interactions / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D020641:Polymorphism, Single Nucleotide; D012720:Severity of Illness Index
chemical_list: D020413:3' Untranslated Regions; D015234:HLA-A Antigens
keywords: Chlamydia trachomatis; HLA; SNP; host genetic factors; susceptibility; tubal pathology