title: Asymmetric Synthesis of 1,2-Diamines bearing Tetrasubstituted Centers from Nonstabilized Azomethine Ylides and N-Sulfinylketimines under Brønsted Acid Catalysis.
abstract: The first asymmetric cycloaddition of nonstabilized azomethine ylide and N-sulfinylimines is presented. In reactions with aryl-alkyl and heteroaryl-alkyl ketimines, excellent diastereoselectivities and good yields are obtained in all cases, regardless of the electronic character of the substituents at the aromatic rings. Moreover, the cycloadducts obtained can easily be deprotected in acid media, giving access to free 1,2-diamines which are prevalent in many natural and pharmaceutical products.
authors.affiliation: Organic Chemistry Department, Science Faculty, Universidad Autonóma de Madrid , Madrid 28049, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Izquierdo
authors.affiliation: Organic Chemistry Department, Science Faculty, Universidad Autonóma de Madrid , Madrid 28049, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Esteban
authors.affiliation: Organic Chemistry Department, Science Faculty, Universidad Autonóma de Madrid , Madrid 28049, Spain.
authors.forename: José Luis García
authors.initials: JL
authors.lastname: Ruano
authors.affiliation: Organic Chemistry Department, Science Faculty, Universidad Autonóma de Madrid , Madrid 28049, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Fraile
authors.affiliation: Organic Chemistry Department, Science Faculty, Universidad Autonóma de Madrid , Madrid 28049, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Alemán