title: Opinion of the Scientific Committee on Consumer safety (SCCS) - Opinion on the safety of the use of deoxyarbutin in cosmetic products.
abstract: Although on the basis of the provided scientific data the use of deoxyarbutin as such can be considered safe for consumers in cosmetic products in a concentration up to 3% in face creams, hydroquinone will be formed at levels which raise concerns with regard to the safety of such products during life-cycle of the product (e.g. storage conditions and stability under in-use conditions). Therefore, the overall conclusion of the SCCS is that the use of deoxyarbutin up to 3% in face creams is not safe.
authors.affiliation: SCCS Secretariat at the European Commission, Directorate General for Health and Food Safety, 11, rue E. Ruppert, L-2920, Luxembourg, Luxembourg. Electronic address: SANTE-C2-SCCS@ec.europa.eu.
authors.lastname: Sccs
authors.affiliation: Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany.
authors.forename: Gisela H
authors.initials: GH
authors.lastname: Degen
mesh_terms: D000818:Animals; D001104:Arbutin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000032:analysis; D003257:Consumer Product Safety; D006801:Humans; D006873:Hydroquinones / Q000009:adverse effects / Q000032:analysis; D018570:Risk Assessment; D063465:Skin Cream / Q000009:adverse effects* / Q000032:analysis
chemical_list: D006873:Hydroquinones; D001104:Arbutin; C504954:deoxyarbutin; C031927:hydroquinone
keywords: CAS 53936-56-4; Deoxyarbutin; Regulation 1223/2009; SCCS; Scientific opinion; Tetrahydropyranyloxy phenol