title: The influence of gender on 'tissue at risk' in acute stroke: A diffusion-weighted magnetic resonance imaging study in a rat model of focal cerebral ischaemia.
abstract: This is the first study to assess the influence of sex on the evolution of ischaemic injury and penumbra. Permanent middle cerebral artery occlusion was induced in male (n = 9) and female (n = 10) Sprague-Dawley rats. Diffusion-weighted imaging was acquired over 4 h and infarct determined from T2 images at 24 h post-permanent middle cerebral artery occlusion. Penumbra was determined retrospectively from serial apparent diffusion coefficient lesions and T2-defined infarct. Apparent diffusion coefficient lesion volume was significantly smaller in females from 0.5 to 4 h post permanent middle cerebral artery occlusion as was infarct volume. Penumbral volume, and its loss over time, was not significantly different despite the sex difference in acute and final lesion volumes.
authors.affiliation: Glasgow Experimental MRI Centre (GEMRIC), Institute of Neuroscience & Psychology, College of Medical, Veterinary & Life Sciences (MVLS), University of Glasgow, Glasgow, UK.
authors.forename: Tracey A
authors.initials: TA
authors.lastname: Baskerville
authors.affiliation: Glasgow Experimental MRI Centre (GEMRIC), Institute of Neuroscience & Psychology, College of Medical, Veterinary & Life Sciences (MVLS), University of Glasgow, Glasgow, UK Mhairi.Macrae@glasgow.ac.uk.
authors.forename: I Mhairi
authors.initials: IM
authors.lastname: Macrae
authors.affiliation: Glasgow Experimental MRI Centre (GEMRIC), Institute of Neuroscience & Psychology, College of Medical, Veterinary & Life Sciences (MVLS), University of Glasgow, Glasgow, UK.
authors.forename: William M
authors.initials: WM
authors.lastname: Holmes
authors.affiliation: Glasgow Experimental MRI Centre (GEMRIC), Institute of Neuroscience & Psychology, College of Medical, Veterinary & Life Sciences (MVLS), University of Glasgow, Glasgow, UK.
authors.forename: Christopher
authors.initials: C
authors.lastname: McCabe
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000401:mortality / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D005260:Female; D007091:Image Processing, Computer-Assisted; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics; D020521:Stroke / Q000401:mortality / Q000473:pathology*
keywords: Acute stroke; MCAO; diffusion-weighted MRI; gender