title: Infliximab eye drops treatment in corneal neovascularization.
abstract: Corneal neovascularization is a serious condition that may arise secondary to chemical burns, ischemia, infection, trauma, and inflammation and represents a major cause of blindness. This study investigated the efficacy of topical application of infliximab [tumor necrosis factor-a (TNF-a) monoclonal antibody] in the treatment of corneal neovascularization in the rabbit model.
authors.affiliation: Department of Cellular and Molecular Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: O B
authors.initials: OB
authors.lastname: Voiculescu
authors.affiliation: Department of Ophthalmology, University Emergency Hospital Bucharest, Romania.
authors.forename: L M
authors.initials: LM
authors.lastname: Voinea
mesh_terms: D000468:Alkalies / Q000737:chemistry; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D016510:Corneal Neovascularization / Q000188:drug therapy* / Q000473:pathology; D000069285:Infliximab / Q000627:therapeutic use*; D009883:Ophthalmic Solutions / Q000627:therapeutic use*; D011817:Rabbits
chemical_list: D000468:Alkalies; D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D009883:Ophthalmic Solutions; D000069285:Infliximab
keywords: antiVEGF agents; neovascularization