title: Colorectal Cancer Screening in Inflammatory Bowel Disease.
abstract: Patients with long-standing ulcerative colitis (UC) or Crohn's colitis are at increased risk of developing colorectal cancer (CRC). Given that most cases of CRC are thought to arise from dysplasia, previous guidelines have recommended endoscopic surveillance with random biopsies obtained from all segments of the colon involved by endoscopic or microscopic inflammation. However, recent evidence has suggested that the majority of dysplastic lesions in patients with inflammatory disease (IBD) are visible, and data have been supportive of chromoendoscopy with targeted biopsies of visible lesions versus traditional random biopsies. This review article will discuss the risk of colon cancer in patients with IBD, as well as current recommendations for CRC screening and surveillance in patients with UC or Crohn's colitis.
authors.affiliation: Division of Gastroenterology, Beth Israel Deaconess Medical Center, 110 Francis St 8E Gastroenterology, Boston, MA, 02215, USA.
authors.forename: Neil
authors.initials: N
authors.lastname: Sengupta
authors.affiliation: Division of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Yee
authors.affiliation: Division of Gastroenterology, Beth Israel Deaconess Medical Center, 110 Francis St 8E Gastroenterology, Boston, MA, 02215, USA. jfeuerst@bidmc.harvard.edu.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Feuerstein
mesh_terms: D003111:Colonic Polyps / Q000175:diagnosis; D039021:Colonic Pouches; D003113:Colonoscopy / Q000379:methods; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008403:Mass Screening; D011159:Population Surveillance; D012307:Risk Factors
keywords: Colon cancer screening; Crohn’s disease; Inflammatory bowel disease; Ulcerative colitis