title: Injectability, microstructure and release properties of sodium fusidate-loaded apatitic cement as a local drug-delivery system.
abstract: The introduction of an antibiotic, sodium fusidate (SF), into the liquid phase of calcium carbonate-calcium phosphate (CaCO3-CaP) bone cement was evaluated, considering the effect of the liquid to powder ratio (L/P) on the composition and microstructure of the set cement and the injectability of the paste. In all cases, we obtained set cements composed mainly of biomimetic carbonated apatite analogous to bone mineral. With this study, we evi-denced a synergistic effect of the L/P ratio and SF presence on the injectability (i.e., the filter-pressing pheno-menon was suppressed) and the setting time of the SF-loaded cement paste compared to reference cement (without SF). In addition, the in vitro study of SF release, according to the European Pharmacopoeia recommendations, showed that, regardless of the L/P ratio, the cement allowed a sustained release of the antibiotic over 1month in sodium chloride isotonic solution at 37°C and pH7.4; this release is discussed considering the microstructure characteristics of SF-loaded cements (i.e., porosity, pore-size distribution) before and after the release test. Finally, modelling antibiotic release kinetics with several models indicated that the SF release was controlled by a diffusion mechanism.
authors.affiliation: CIRIMAT, UPS-INPT-CNRS, ENSIACET, University of Toulouse, 4 allée Emile Monso, CS 44362, 31030 Toulouse Cedex 4, France; LPCME-CNRST-URAC 20, Department of Chemistry, Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco.
authors.forename: Hassan
authors.initials: H
authors.lastname: Noukrati
authors.affiliation: CIRIMAT, UPS-INPT-CNRS, Faculté des Sciences Pharmaceutiques, University of Toulouse, 118 Route de Narbonne, 31062 Toulouse Cedex 4, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Cazalbou
authors.affiliation: CIRIMAT, UPS-INPT-CNRS, ENSIACET, University of Toulouse, 4 allée Emile Monso, CS 44362, 31030 Toulouse Cedex 4, France.
authors.forename: Imane
authors.initials: I
authors.lastname: Demnati
authors.affiliation: CIRIMAT, UPS-INPT-CNRS, ENSIACET, University of Toulouse, 4 allée Emile Monso, CS 44362, 31030 Toulouse Cedex 4, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Rey
authors.affiliation: LPCME-CNRST-URAC 20, Department of Chemistry, Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco.
authors.forename: Allal
authors.initials: A
authors.lastname: Barroug
authors.affiliation: CIRIMAT, UPS-INPT-CNRS, ENSIACET, University of Toulouse, 4 allée Emile Monso, CS 44362, 31030 Toulouse Cedex 4, France. Electronic address: christele.combes@ensiacet.fr.
authors.forename: Christèle
authors.initials: C
authors.lastname: Combes
mesh_terms: D001031:Apatites / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D001843:Bone Cements / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D005672:Fusidic Acid / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D001031:Apatites; D001843:Bone Cements; D005672:Fusidic Acid
keywords: Antibiotic; Apatite cements; Delivery system; Drug release; Injectability