title: Effect of rs1344706 in the ZNF804A gene on the connectivity between the hippocampal formation and posterior cingulate cortex.
abstract: ZNF804A is one of the most promising candidate genes for schizophrenia. Previous fMRI studies have repeatedly shown an association between SNP rs1344706 in this gene and the functional connectivity from the right dorsolateral prefrontal cortex (rDLPFC) to the left hippocampal formation (lHF) during the N-back task. However, the rDLPFC-lHF functional connectivity included several subconnections and it is not known whether rs1344706 plays the same role in these subconnections. This study addressed that question using both fMRI and DTI data of 87 subjects. First, we replicated the association between rs1344706 and the rDLPFC-lHF functional connectivity using our fMRI data from the N-back task. Second, we reconstructed fiber connections between rDLPFC and lHF using our DTI data, which included three subconnections: from lHF to posterior cingulate cortex (PCC), from PCC to anterior cingulated cortex (ACC), and from ACC to rDLPFC. We found that only the lHF-PCC tract showed significantly lower fractional anisotropy (FA) in risk allele homozygotes. Finally, we analyzed the fMRI data (from the N-back task and the resting state). Both consistently showed relatively lower lHF-PCC functional connectivity in risk allele homozygotes. Taken together, the disconnectivity of the lHF-PCC tract seems to be a plausible intermediate phenotype that links rs1344706 and schizophrenia.
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, PR China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, PR China.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, PR China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, PR China.
authors.forename: Xiongying
authors.initials: X
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, PR China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yu
authors.affiliation: School of Mental Health, Jining Medical University, 45# Jianshe South Road, Jining 272013, Shandong Province, PR China.
authors.forename: Qiumei
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, PR China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, PR China.
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, PR China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, PR China.
authors.forename: Huang
authors.initials: H
authors.lastname: Gu
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, PR China; Key Laboratory of Opto-electronics Information Technology, Ministry of Education, Tianjin 300072, PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: School of Mental Health, Jining Medical University, 45# Jianshe South Road, Jining 272013, Shandong Province, PR China.
authors.forename: Jinguo
authors.initials: J
authors.lastname: Zhai
authors.affiliation: School of Mental Health, Jining Medical University, 45# Jianshe South Road, Jining 272013, Shandong Province, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, PR China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, PR China.
authors.forename: Boqi
authors.initials: B
authors.lastname: Du
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, PR China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, PR China.
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Deng
authors.affiliation: School of Mental Health, Jining Medical University, 45# Jianshe South Road, Jining 272013, Shandong Province, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Ji
authors.affiliation: Beijing Anding Hospital, Beijing 100088, PR China.
authors.forename: Chuanyue
authors.initials: C
authors.lastname: Wang
authors.affiliation: Beijing Anding Hospital, Beijing 100088, PR China; Faculty of Health Sciences, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau.
authors.forename: Yutao
authors.initials: Y
authors.lastname: Xiang
authors.affiliation: Center for Cognitive Neuroscience, Duke University, Durham, NC, USA.
authors.forename: Dawei
authors.initials: D
authors.lastname: Li
authors.affiliation: Shengli Hospital of Shengli Petroleum Administration Bureau, Dongying 257022, Shandong Province, PR China.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, PR China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, PR China. Electronic address: lijundp@bnu.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, PR China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, PR China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Dong
authors.affiliation: Department of Psychology and Social Behavior, University of California, Irvine, CA 92697, USA.
authors.forename: Chuansheng
authors.initials: C
authors.lastname: Chen
mesh_terms: D000328:Adult; D001931:Brain Mapping; D056324:Diffusion Tensor Imaging; D005260:Female; D007839:Functional Laterality; D060005:Genotyping Techniques; D006179:Gyrus Cinguli / Q000033:anatomy & histology* / Q000502:physiology*; D006624:Hippocampus / Q000033:anatomy & histology* / Q000502:physiology*; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide; D011930:Reaction Time; D012146:Rest
chemical_list: D051741:Kruppel-Like Transcription Factors; C540527:ZNF804A protein, human
keywords: Dorsolateral prefrontal cortex; Functional connectivity; Hippocampal formation; Posterior cingulate cortex; ZNF804A