title: Electrophysiological effects of non-invasive Radio Electric Asymmetric Conveyor (REAC) on thalamocortical neural activities and perturbed experimental conditions.
abstract: The microwave emitting Radio Electric Asymmetric Conveyor (REAC) is a technology able to interact with biological tissues at low emission intensity (2 mW at the emitter and 2.4 or 5.8 GHz) by inducing radiofrequency generated microcurrents. It shows remarkable biological effects at many scales from gene modulations up to functional global remodeling even in human subjects. Previous REAC experiments by functional Magnetic Resonance Imaging (fMRI) on healthy human subjects have shown deep modulations of cortical BOLD signals. In this paper we studied the effects of REAC application on spontaneous and evoked neuronal activities simultaneously recorded by microelectrode matrices from the somatosensory thalamo-cortical axis in control and chronic pain experimental animal models. We analyzed the spontaneous spiking activity and the Local Field Potentials (LFPs) before and after REAC applied with a different protocol. The single neuron spiking activities, the neuronal responses to peripheral light mechanical stimuli, the population discharge synchronies as well as the correlations and the network dynamic connectivity characteristics have been analyzed. Modulations of the neuronal frequency associated with changes of functional correlations and significant LFP temporal realignments have been diffusely observed. Analyses by topological methods have shown changes in functional connectivity with significant modifications of the network features.
authors.affiliation: Institute of Molecular Bioimaging and Physiology, Dept. of Bio-Medicine, National Research Council (CNR), LITA Bldg., Via Fratelli Cervi, 93, 20090 Segrate (Milan), Italy.
authors.forename: Antonio G
authors.initials: AG
authors.lastname: Zippo
authors.affiliation: Department of Regenerative Medicine, Rinaldi Fontani Institute, Viale Belfiore 43, 50144 Florence, Italy.|Department of Neuro Psycho Physical Optimization, Rinaldi Fontani Institute, Viale Belfiore 43, 50144 Florence, Italy.|Research Department, Rinaldi Fontani Foundation - NPO, Viale Belfiore 43, 50144 Florence, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Rinaldi
authors.affiliation: Institute of Molecular Bioimaging and Physiology, Dept. of Bio-Medicine, National Research Council (CNR), LITA Bldg., Via Fratelli Cervi, 93, 20090 Segrate (Milan), Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Pellegata
authors.affiliation: Institute of Biomedical Technology, National Research Council, (CNR), LITA Bldg., Via Fratelli Cervi, 93, 20090 Segrate (Milan), Italy.
authors.forename: Gian Carlo
authors.initials: GC
authors.lastname: Caramenti
authors.affiliation: Institute of Molecular Bioimaging and Physiology, Dept. of Bio-Medicine, National Research Council (CNR), LITA Bldg., Via Fratelli Cervi, 93, 20090 Segrate (Milan), Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Valente
authors.affiliation: Department of Regenerative Medicine, Rinaldi Fontani Institute, Viale Belfiore 43, 50144 Florence, Italy.|Department of Neuro Psycho Physical Optimization, Rinaldi Fontani Institute, Viale Belfiore 43, 50144 Florence, Italy.|Research Department, Rinaldi Fontani Foundation - NPO, Viale Belfiore 43, 50144 Florence, Italy.
authors.forename: Vania
authors.initials: V
authors.lastname: Fontani
authors.affiliation: Institute of Molecular Bioimaging and Physiology, Dept. of Bio-Medicine, National Research Council (CNR), LITA Bldg., Via Fratelli Cervi, 93, 20090 Segrate (Milan), Italy.
authors.forename: Gabriele E M
authors.initials: GE
authors.lastname: Biella
mesh_terms: D000200:Action Potentials; D000818:Animals; D001921:Brain / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology*; D059350:Chronic Pain / Q000628:therapy; D055724:Electrophysiological Phenomena; D008872:Microwaves; D051381:Rats; D013788:Thalamus / Q000502:physiology*