title: The importance of surgical margins in melanoma.
abstract: Optimization of margins to minimize morbidity and maximize local control is critical to the success of surgical management of primary melanomas. This article synthesizes the historical perspectives and key clinical trials that have contributed to the evolution of resection margins for melanoma, focusing on the importance of surgical margins in the context of an era of improvements in systemic therapy and greater use of minimally invasive techniques.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, Georgia.
authors.forename: Cecilia G
authors.initials: CG
authors.lastname: Ethun
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, Georgia.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Delman
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005629:Frozen Sections; D006801:Humans; D008545:Melanoma / Q000473:pathology* / Q000601:surgery*; D015580:Mohs Surgery; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D017410:Practice Guidelines as Topic; D018714:Radiotherapy, Adjuvant; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery*; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents
keywords: Mohs micrographic surgery; guidelines; immunotherapy; prospective trial; wide local excision