title: A mild hydration of nitriles catalysed by copper(ii) acetate.
abstract: A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.
authors.affiliation: Department of Chemistry, University of Bath, Claverton Down, BA2 7AY, Bath, England. J.M.J.Williams@bath.ac.uk.
authors.forename: Patricia
authors.initials: P
authors.lastname: Marcé
authors.affiliation: Department of Chemistry, University of Bath, Claverton Down, BA2 7AY, Bath, England. J.M.J.Williams@bath.ac.uk.
authors.forename: James
authors.initials: J
authors.lastname: Lynch
authors.affiliation: Institute of Process Research & Development, School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK.
authors.forename: A John
authors.initials: AJ
authors.lastname: Blacker
authors.affiliation: Department of Chemistry, University of Bath, Claverton Down, BA2 7AY, Bath, England. J.M.J.Williams@bath.ac.uk.
authors.forename: Jonathan M J
authors.initials: JM
authors.lastname: Williams