title: Probing the molecular mechanism of cerium oxide nanoparticles in protecting against the neuronal cytotoxicity of Aβ1-42 with copper ions.
abstract: The molecular mechanism of CeONP in protecting against neuronal cytotoxicity from amyloid peptides and copper ions was investigated systematically by photoluminescence of [Ru(phen)2dppz](2+), morphology of TEM, mass spectroscopy, cell viability assay, ROS fluorescence assay, and EPR. The results revealed that CeONPs reduced Aβ1-42 aggregation, protected from neurotoxicity of ROS induced by Cu(2+) + Aβ1-42via blocking the production of free radicals and scavenging the radicals with Ce(3+)/Ce(4+) catalytic cycles, which provides a valuable insight into CeONPs as a therapeutic intervention in oxidative damage in Alzheimer's disease.
authors.affiliation: Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China. xstan@fudan.edu.cn.
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China. xstan@fudan.edu.cn.
authors.forename: Qiming
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China. xstan@fudan.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Medical Neurobiology, Shanghai Medical College of Fudan University, Shanghai, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Chemistry & College Station High School, Texas A&M University, Texas 77845, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Tan
authors.affiliation: State Key Laboratory of Medical Neurobiology, Shanghai Medical College of Fudan University, Shanghai, China.
authors.forename: Cuiqing
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China. xstan@fudan.edu.cn.
authors.forename: Xiangshi
authors.initials: X
authors.lastname: Tan
mesh_terms: D016229:Amyloid beta-Peptides; D002470:Cell Survival; D002563:Cerium / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology*; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009447:Neuroblastoma / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D010084:Oxidation-Reduction; D010446:Peptide Fragments; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D020011:Protective Agents; C075222:amyloid beta-protein (1-42); D002563:Cerium; C030583:ceric oxide; D003300:Copper