title: TRIENNIAL LACTATION SYMPOSIUM: Nutrient partitioning during intramammary inflammation: A key to severity of mastitis and risk of subsequent diseases?
abstract: In early lactation, susceptibility to disease is greatest, impacting cow health and productivity and leading to economic losses. Mastitis is the most economically costly disease to the dairy industry and is most frequent at this time. The objective of this paper is to discuss the energetic fuels used by leukocytes in the metabolic response during mastitis that may reveal potential mechanisms linking mastitis with the development of subsequent metabolic diseases for dairy cows during lactation. Glucose and glutamine are the primary fuels used by leukocytes and are essential substrates for optimal leukocyte function. Yet because these substrates are in high demand to support milk synthesis during early lactation, their supply to leukocytes may be compromised and may partly contribute to immunosuppression observed at this time. Production-related metabolic diseases during early lactation, such as ketosis and hepatic lipidosis, can also adversely affect health and productivity. Risk of subsequent disease for cows during mastitis has not been fully elucidated. Regardless of stage of lactation and physiological state, increases in circulating NEFA and glucose and decreases in ketones during an intramammary inflammation in dairy cows have been reported. In addition, previous work indicates that hepatic metabolism may be impaired during inflammation. These results indicate a potential link between mastitis and the risk of subsequent metabolic disease for dairy cows during lactation. This paper will discuss the complex relationships between metabolism and immune function and how these immunometabolic interactions relate mastitis with increased risk of subsequent disease during early lactation.
authors.forename: K M
authors.initials: KM
authors.lastname: Moyes
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002417:Cattle; D005260:Female; D006801:Humans; D007249:Inflammation / Q000473:pathology / Q000662:veterinary*; D008321:Mammary Glands, Animal / Q000473:pathology; D008414:Mastitis, Bovine / Q000209:etiology*; D012307:Risk Factors