title: Enantioseparation of Six Antihistamines with Immobilized Cellulose Chiral Stationary Phase by HPLC.
abstract: A stereoselective high performance liquid chromatography method has been developed for the chiral separation of the enantiomers of six antihistamines, doxylamine, carbinoxamine, dioxopromethazine, oxomemazine, cetirizine and hydroxyzine. The effects of mobile phase additive, column temperature and flow rate on the retention time and resolution were studied. Enantiomeric separation of cetirizine, doxylamine and hydroxyzine were achieved on cellulose tris-(3,5-dichlorophenylcarbamate) immobilized on silica gel chiral stationary phase known as Chiralpak IC (RS = 3.74, RS = 1.85 and RS = 1.74, respectively).
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan 450001, P.R. China jie_0822@163.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors.forename: Pei
authors.initials: P
authors.lastname: Luo
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors.forename: Lingchang
authors.initials: L
authors.lastname: Meng
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors.forename: Chong
authors.initials: C
authors.lastname: Sun
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors.forename: Qiuzheng
authors.initials: Q
authors.lastname: Du
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Sun
mesh_terms: D002482:Cellulose / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation*; D006633:Histamine Antagonists / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D006633:Histamine Antagonists; D002482:Cellulose