title: [Cohort study of effects on lung function of coke oven workers exposured to coke oven emissions].
abstract: OBJECTIVE
  Through comparative study on pulmonary function damage of coke oven workers exposed to coke oven emissions with the same group before and after five years, and further explore the relationship between the coke oven emissions and injury in pulmonary function of coke oven worker.
  
  
  METHODS
  Select a coking plant in Shanxi 165 coke oven workers (exposed group) and 52 auxiliary workers (control group) for the study, using a uniform questionnaire to collect workers' personal information. Fixed workplace air samples collected periodically. Air samples of benzo (a) pyrene concentrations was measured by high pressure liquid chromatograph. Pulmonary function of research object was measured by portable spirometer respectively in 2009 and 2013, and comparative analysis on it.
  
  
  RESULTS
  The concentration of B(a)P was no significant difference in the same area between 5 years in 2009-2013. Compared with 2009, 2013 control workers lung function index and the abnormal rate had no significant difference (P > 0.05). But FVC%, FEV1.0%, MVV%, VC% and FEF25% of exposed workers in 2013 was significantly lower than in 2009, FVC%, FEV1.0%, VC% and FEF25% pulmonary dysfunction rate in 2013 was also significantly higher than in 2009, difference was statistically significant (P < 0.05). Workers emerging pulmonary function abnormalities mainly distributed in furnace roof and side. furnace roof group FVC%, FEV1.0%, VC% additional abnormal number (rate) was significantly higher than furnace floor and the control group (P < 0.05), and furnace side groop was significantly higher than the control group, the difference was statistically significant (P < 0.05). Multivariate Logistic regression analysis showed that after 5 years FVC%, FEV1% and VC% of abnormal lung function emerging adjusted OR of furnace roof workers were 7.939, 5.966 and 4.956. For abnormal of FVC%, FEV1%, VC% and MVV%, the contacting coke seniority is a risk factor. There is a positive interaction between contacting coke seniority and furnace roof (P < 0.05).
  
  
  CONCLUSIONS
  Coke oven workers lung function damage associated with exposureing to coke oven emissions, coke oven emissions exposure level and exposure time are the main factors of coke oven workers in lung function damage, there is a positive interaction between the two factors.
authors.affiliation: Department of Toxicology, Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Yongfen
authors.initials: Y
authors.lastname: Zhi
authors.forename: Hongming
authors.initials: H
authors.lastname: Zhang
authors.forename: Weixing
authors.initials: W
authors.lastname: Li
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Hu
authors.forename: Weihua
authors.initials: W
authors.lastname: Liu
authors.forename: Yangfan
authors.initials: Y
authors.lastname: Li
authors.affiliation: E-mail: sytoxi6322@126.com.
authors.forename: Jinpin
authors.initials: J
authors.lastname: Zheng
mesh_terms: D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000032:analysis; D001564:Benzo(a)pyrene / Q000009:adverse effects* / Q000032:analysis; D015331:Cohort Studies; D003077:Coke; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000503:physiopathology*; D016273:Occupational Exposure / Q000009:adverse effects*; D012129:Respiratory Function Tests; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D000395:Air Pollutants, Occupational; D003077:Coke; D001564:Benzo(a)pyrene