title: Does CD10 Expression Predict Lymph Node Metastasis in Colorectal Cancer?
abstract: BACKGROUND
  Accurate preoperative prediction of lymph node status would be a revolutionary adjunct in treating colorectal cancer. The immunohistochemical marker CD10 has been suggested recently to have a predictive capacity for lymph node involvement in colorectal cancer.
  
  
  OBJECTIVE
  The aim of our study was to evaluate the relationship between the presence of the CD10 molecular marker and lymph node metastasis in a US patient population using previously banked colorectal cancer specimens.
  
  
  METHODS
  This was a retrospective study.
  
  
  METHODS
  The study was conducted at a single academic institution.
  
  
  METHODS
  Included were specimens from 191 patients, with cancer stages ranging from T1N0 to T3N2.
  
  
  METHODS
  The relationship between CD10 and different clinicopathologic parameters was assessed, as well as the ability to predict lymph node metastasis by itself and in conjunction with lymphovascular invasion.
  
  
  RESULTS
  CD10 was significantly correlated with left-sided colon cancers (p = 0.01) and the presence of mucinous histology and had a relatively high specificity (75.7%) for lymph node metastasis. CD10 did not correlate with lymph node status (p = 0.33) or enhance the ability of lymphovascular invasion to predict lymphatic metastasis in our patient population. Sensitivity and specificity of lymphovascular invasion alone for lymph node metastasis were 62.8% and 93.6%, whereas adding CD10 status resulted in a sensitivity of 70.6% and specificity of 69.3%. Multivariate analysis revealed only lymphovascular invasion as a predictor of lymph node metastasis in our patient population.
  
  
  CONCLUSIONS
  This study was primarily limited by its small sample size and retrospective nature.
  
  
  CONCLUSIONS
  In our patient population, CD10 status was not significantly associated with lymph node metastasis, and it was no better than lymphovascular invasion alone when predicting lymph node status.
authors.affiliation: 1 Grand Rapids Medical Education Partners/Michigan State University Colorectal Surgery, Spectrum Health, Grand Rapids, Michigan 2 Division of Surgical Subspecialties, Colon and Rectal Surgery/Spectrum Health, Spectrum Health Medical Group, Grand Rapids, Michigan 3 Division of Colorectal Surgery, Spectrum Health/Ferguson Clinic, Michigan State University, Grand Rapids, Michigan.
authors.forename: Irina
authors.initials: I
authors.lastname: Bernescu
authors.forename: Ari C
authors.initials: AC
authors.lastname: Reichstein
authors.forename: Martin
authors.initials: M
authors.lastname: Luchtefeld
authors.forename: James W
authors.initials: JW
authors.lastname: Ogilvie