title: Possible mechanisms of Pseudomonas aeruginosa-associated lung disease.
abstract: Pseudomonas aeruginosa is an opportunistic bacterium causing lung injury in immunocompromised patients correlated with high morbidity and mortality. Many bacteria, including P. aeruginosa, use extracellular signals to synchronize group behaviors, a process known as quorum sensing (QS). In the P. aeruginosa complex QS system controls expression of over 300 genes, including many involved in host colonization and disease. P. aeruginosa infection elicits a complex immune response due to a large number of immunogenic factors present in the bacteria or released during infection. Here, we focused on the mechanisms by which P. aeruginosa triggers lung injury and inflammation, debating the possible ways that P. aeruginosa evades the host immune system, which leads to immune suppression and resistance.
authors.affiliation: Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil. Electronic address: cassianofg@gmail.com.
authors.forename: Cassiano Felippe
authors.initials: CF
authors.lastname: Gonçalves-de-Albuquerque
authors.affiliation: Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil.
authors.forename: Adriana Ribeiro
authors.initials: AR
authors.lastname: Silva
authors.affiliation: Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, Brazil.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Burth
authors.affiliation: Laboratório de Investigação Pulmonar, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Patricia Rieken Macêdo
authors.initials: PR
authors.lastname: Rocco
authors.affiliation: Laboratório Integrado de Nefrologia, Departamento de Medicina Interna, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Mauro Velho
authors.initials: MV
authors.lastname: Castro-Faria
authors.affiliation: Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil.
authors.forename: Hugo Caire
authors.initials: HC
authors.lastname: Castro-Faria-Neto
mesh_terms: D015964:Gene Expression Regulation, Bacterial; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D007249:Inflammation / Q000473:pathology; D055370:Lung Injury / Q000473:pathology*; D018410:Pneumonia, Bacterial / Q000473:pathology*; D011550:Pseudomonas aeruginosa / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D053038:Quorum Sensing
keywords: Inflammation; Lung injury; Pseudomonas aeruginosa