title: Group A streptococcal strains isolated in Lao People's Democratic Republic from 2004 to 2013.
abstract: Epidemiological data regarding group A streptococcal (GAS) infections in South East Asia are scarce with no information from Laos. We characterized emm types, emm clusters and the antibiotic resistance profile of 124 GAS isolates recovered in Laos during 2004-2013. Most strains were recovered from skin and invasive infections (76% and 19%, respectively). Thirty-four emm types were identified as belonging to 12 emm clusters and no novel emm types were identified. No significant differences were observed in the distribution of emm types or emm clusters according to age or site of recovery (skin or invasive infections). There was moderate strain diversity in this country but considerable differences in emm-type distribution between Laos, Thailand and Cambodia. Vaccine coverage was high for the J8 vaccine candidate. The theoretical coverage for the 30-valent vaccine candidate needs further investigation. Antibiotic resistance was moderate to erythromycin and chloramphenicol (8% and 7%, respectively) and low to ofloxacin (<1%).
authors.affiliation: Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit,Microbiology Laboratory,Mahosot Hospital,Vientiane,Lao People's Democratic Republic.
authors.forename: S
authors.initials: S
authors.lastname: Rattanavong
authors.affiliation: Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit,Microbiology Laboratory,Mahosot Hospital,Vientiane,Lao People's Democratic Republic.
authors.forename: D A B
authors.initials: DA
authors.lastname: Dance
authors.affiliation: Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit,Microbiology Laboratory,Mahosot Hospital,Vientiane,Lao People's Democratic Republic.
authors.forename: V
authors.initials: V
authors.lastname: Davong
authors.affiliation: Group A Streptococcus Research Group,Murdoch Children's Research Institute,Melbourne,Australia.
authors.forename: C
authors.initials: C
authors.lastname: Baker
authors.affiliation: Group A Streptococcus Research Group,Murdoch Children's Research Institute,Melbourne,Australia.
authors.forename: H
authors.initials: H
authors.lastname: Frost
authors.affiliation: Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit,Microbiology Laboratory,Mahosot Hospital,Vientiane,Lao People's Democratic Republic.
authors.forename: R
authors.initials: R
authors.lastname: Phetsouvanh
authors.affiliation: Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit,Microbiology Laboratory,Mahosot Hospital,Vientiane,Lao People's Democratic Republic.
authors.forename: M
authors.initials: M
authors.lastname: Vongsouvath
authors.affiliation: Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit,Microbiology Laboratory,Mahosot Hospital,Vientiane,Lao People's Democratic Republic.
authors.forename: P N
authors.initials: PN
authors.lastname: Newton
authors.affiliation: Group A Streptococcus Research Group,Murdoch Children's Research Institute,Melbourne,Australia.
authors.forename: A C
authors.initials: AC
authors.lastname: Steer
authors.affiliation: Group A Streptococcus Research Group,Murdoch Children's Research Institute,Melbourne,Australia.
authors.forename: P R
authors.initials: PR
authors.lastname: Smeesters
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000942:Antigens, Bacterial / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D024881:Drug Resistance, Bacterial; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007812:Laos / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D017720:Molecular Epidemiology; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000382:microbiology* / Q000517:prevention & control; D022541:Streptococcal Vaccines / Q000008:administration & dosage; D013297:Streptococcus pyogenes / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D014611:Vaccination / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D022541:Streptococcal Vaccines; C014689:streptococcal M protein
keywords: Molecular epidemiology; Streptococcus pyogenes; vaccines