title: [To study the effect of injection dexmedetomidine for prevention of pain due to propofol injection and to compare it with injection lignocaine].
abstract: BACKGROUND
  Pain due to injection propofol is a common problem. Different methods are used to decrease the pain but with limited success. The objective of this study was to assess the effect of injection dexmedetomidine 0.2mcg/kg for prevention of pain due to propofol injection and compare it with injection lignocaine 0.2mg/kg.
  
  
  METHODS
  After taking permission of the Institutional Ethical Committee, written informed consent was obtained from all patients, in a randomized prospective study. 60 American Society of Anesthesiology I and II patients of age range 20-60 years of either sex posted for elective surgeries under general anaesthesia were randomly allocated into two groups. Group I (dexmedetomidine group): Inj. dexmedetomidine 0.2mcg/kg diluted in 5mL normal saline and Group II (lignocaine group): Inj. lignocaine 0.2mg/kg diluted in 5mL normal saline. IV line was secured with 20G cannula and venous occlusion was applied to forearm using a pneumatic tourniquet and inflated to 70mm Hg for 1min. Study drug was injected, tourniquet released and then 25% of the calculated dose of propofol was given intravenously over 10s. After 10s of injection, severity of pain was evaluated using McCrirrick and Hunter scale and then remaining propofol and neuromuscular blocking agent was given. Endotracheal intubation was done and anaesthesia was maintained on O2, N2O and isoflurane on intermittent positive pressure ventilation with Bain's circuit and inj. vecuronium was used as muscle relaxant.
  
  
  RESULTS
  Demographic data showed that there was no statistically significant difference between the 2 groups. There was no statistically significant difference between 2 groups in respect to inj. propofol pain. No adverse effects like oedema, pain, wheal response at the site of injection were observed in the two groups.
authors.affiliation: Departamento de Anestesiologia, YCM Hospital, Pimpri, Pune, Índia. Electronic address: manisha.sapate@gmail.com.
authors.forename: Manisha
authors.initials: M
authors.lastname: Sapate
authors.affiliation: Departamento de Anestesiologia, YCM Hospital, Pimpri, Pune, Índia.
authors.forename: Ujjwala
authors.initials: U
authors.lastname: Andurkar
authors.affiliation: Departamento de Anestesiologia, YCM Hospital, Pimpri, Pune, Índia.
authors.forename: Mugdha
authors.initials: M
authors.lastname: Markandeya
authors.affiliation: Departamento de Anestesiologia, YCM Hospital, Pimpri, Pune, Índia.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Gore
authors.affiliation: Departamento de Anestesiologia, YCM Hospital, Pimpri, Pune, Índia.
authors.forename: Widya
authors.initials: W
authors.lastname: Thatte
keywords: Dexmedetomidina; Dexmedetomidine; Dor; Fenol; Lidocaína; Lignocaine; Pain; Phenol; Propofol