title: NaYF4:Yb/Er@PPy core-shell nanoplates: an imaging-guided multimodal platform for photothermal therapy of cancers.
abstract: Imaging guided photothermal agents have attracted great attention for accurate diagnosis and treatment of tumors. Herein, multifunctional NaYF4:Yb/Er@polypyrrole (PPy) core-shell nanoplates are developed by combining a thermal decomposition reaction and a chemical oxidative polymerization reaction. Within such a composite nanomaterial, the core of the NaYF4:Yb/Er nanoplate can serve as an efficient nanoprobe for upconversion luminescence (UCL)/X-ray computed tomography (CT) dual-modal imaging, the shell of the PPy shows strong near infrared (NIR) region absorption and makes it effective in photothermal ablation of cancer cells and infrared thermal imaging in vivo. Thus, this platform can be simultaneously used for cancer diagnosis and photothermal therapy, and compensates for the deficiencies of individual imaging modalities and satisfies the higher requirements on the efficiency and accuracy for diagnosis and therapy of cancer. The results further provide some insight into the exploration of multifunctional nanocomposites in the photothermal theragnosis therapy of cancers.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Huang
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Radiology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Peng
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Song
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
authors.forename: Yuxuan
authors.initials: Y
authors.lastname: Peng
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
authors.forename: Zhiyin
authors.initials: Z
authors.lastname: Xiao
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
authors.forename: Xijian
authors.initials: X
authors.lastname: Liu
authors.affiliation: Research Center for Analysis and Measurement, Donghua University, Shanghai 201620, China.
authors.forename: Jianmao
authors.initials: J
authors.lastname: Yang
authors.affiliation: Ian Wark Research Institute, University of South Australia, Mawson Lakes 5095, Australia.
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
authors.forename: Junqing
authors.initials: J
authors.lastname: Hu
mesh_terms: D000818:Animals; D004871:Erbium / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008024:Ligands; D049449:Luminescence; D051379:Mice; D008854:Microscopy, Electron; D053761:Nanocomposites / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D019301:Oleic Acid / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D019265:Spectroscopy, Near-Infrared; D014057:Tomography, X-Ray Computed
chemical_list: D008024:Ligands; D011108:Polymers; C512882:poly(isobutylene-alt-maleic acid); D019301:Oleic Acid; D011092:Polyethylene Glycols; D004871:Erbium; D010100:Oxygen