title: Radical-mediated ring contraction in the biosynthesis of 7-deazapurines.
abstract: Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.
authors.affiliation: Department of Chemistry, University of Utah, Salt Lake City, UT 84112, United States. Electronic address: vahe@chem.utah.edu.
authors.forename: Vahe
authors.initials: V
authors.lastname: Bandarian
authors.affiliation: Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Chemistry, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Drennan
mesh_terms: D055162:Biocatalysis; D005609:Free Radicals / Q000737:chemistry; D008025:Ligases / Q000378:metabolism; D011687:Purines / Q000096:biosynthesis* / Q000737:chemistry*
chemical_list: C512929:7-deazapurine; D005609:Free Radicals; D011687:Purines; D008025:Ligases