title: [EXPERIENCE WITH E. COLI LYOPHILIZED BACTERIAL LYSATE OM-89 (URO-VAKSOM®) IN MEN WITH ASYMPTOMATIC BACTERIOSPERMIA].
abstract: Chronic prostatitis is a significant problem of modern urology because it is the most common urological disease among the male population. We consider a 3 month course of OM-89 (Uro-Vaksom®) the most rational treatment of asymptomatic bacteriospermia caused by not only E. coli, but also by coexisting bacteria. Administration of OM-89 (Uro-Vaksom®) for 3 months to patients with asymptomatic bacteriospermia resulted in greater E. coli eradication in 98% of men and no growth of microorganisms in the ejaculate in 66%. Compared to these results, after a 3-4 week course of fluoroquinolones, E. coli occurred in significant titer in 15.2%, in non-significant--in 5.7% and the absence of microbial growth was noted only in 19% of cases. The course of OM-89 (Uro- Vaksom®), compared with fluoroquinolones, resulted in significantly increased sperm concentration and occurrence of greater number of spontaneous pregnancies. Rate of THB (Take Home Baby) for OM-89 (Uro-Vaksom®) group was 21%, for fluoroquinolones treatment group--7%.
authors.forename: D G
authors.initials: DG
authors.lastname: Pochernikov
authors.forename: L V
authors.initials: LV
authors.lastname: Jakovleva
authors.forename: A L
authors.initials: AL
authors.lastname: Strel'nikov
authors.forename: E Ju
authors.initials: EJ
authors.lastname: Vinokurov
authors.forename: D I
authors.initials: DI
authors.lastname: Boldin
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000473:pathology; D024841:Fluoroquinolones / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D011472:Prostatitis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D024841:Fluoroquinolones; C050501:OM 89