title: A signal-on split aptasensor for highly sensitive and specific detection of tumor cells based on FRET.
abstract: We present here a signal-on fluorescence biosensor for highly sensitive and specific detection of tumor cells with a split aptamer based on fluorescence resonance energy transfer (FRET). This sensor holds considerable potential for simple, rapid, sensitive and specific tumor cell detection in early clinical diagnosis.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Changsha, 410082, China. kmwang@hnu.edu.cn guoqping@126.com.
authors.forename: Baoyin
authors.initials: B
authors.lastname: Yuan
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.forename: Qiuping
authors.initials: Q
authors.lastname: Guo
authors.forename: Kemin
authors.initials: K
authors.lastname: Wang
authors.forename: Xiaohai
authors.initials: X
authors.lastname: Yang
authors.forename: Xiangxian
authors.initials: X
authors.lastname: Meng
authors.forename: Jun
authors.initials: J
authors.lastname: Wan
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Tan
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Huang
authors.forename: Qin
authors.initials: Q
authors.lastname: Xie
authors.forename: Xiayu
authors.initials: X
authors.lastname: Zhao
mesh_terms: D031541:Fluorescence Resonance Energy Transfer; D006801:Humans; D057230:Limit of Detection; D009369:Neoplasms / Q000175:diagnosis* / Q000473:pathology