title: microRNA and Wound Healing.
abstract: microRNAs (miRNAs) are small noncoding RNA molecules which play pivotal roles in wound healing. The increased expression of certain genes and expression of some others represent a key component of the wound biology and are largely under the regulation of naturally occurring miRNAs. Understanding the dysregulated miRNAs in chronic wound biology will therefore enable the development of newer therapies. This chapter focuses on the miRNAs that can be potentially targeted for improving skin wound healing and the challenges in miRNA therapy, including considerations in miRNA target identification and delivery.
authors.affiliation: Extremity Trauma and Regenerative Medicine Division, US Army Institute of Surgical Research, 3698 Chambers Pass, BHT-1, Joint Base-San Antonio, Fort Sam Houston, San Antonio, TX, 78234, USA. jaideep.b@gmail.com.
authors.forename: Jaideep
authors.initials: J
authors.lastname: Banerjee
authors.affiliation: The Ohio State University Wexner Medical Center, Davis Heart & Lung Research Institute, Comprehensive Wound Center, Center for Regenerative Medicine & Cell-Based Therapies, 473 West, 12th Avenue, Columbus, OH, 43210, USA. Chandan.Sen@osumc.edu.
authors.forename: Chandan K
authors.initials: CK
authors.lastname: Sen
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D000860:Hypoxia; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics*; D008957:Models, Genetic; D018919:Neovascularization, Physiologic / Q000235:genetics; D062326:Re-Epithelialization / Q000235:genetics / Q000502:physiology; D012867:Skin / Q000098:blood supply / Q000378:metabolism* / Q000503:physiopathology; D012871:Skin Diseases / Q000235:genetics / Q000503:physiopathology; D014945:Wound Healing / Q000235:genetics*
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D035683:MicroRNAs
keywords: Angiogenesis; HypoxymiRs; Inflammation; Re-epithelialization; Wound healing