title: Defensive Diterpene from the Aeolidoidean Phyllodesmium longicirrum.
abstract: Phyllodesmium is a tropical marine slug genus with about 30 described species. None of them have a protective shell, and all of them feed on octocorals that are generally known to provide defensive compounds and thus help to defend the naked slugs against sympatric predators, such as fish, crabs, cephalopods, and echinoderms. Phyllodesmium longicirrum is the species that grows the biggest and that is least protected by camouflage on its respective food, usually a soft coral of the genus Sarcophyton. Investigation of the lipophilic extract of a single specimen of P. longicirrum from the Great Barrier Reef (Australia) led to the isolation of four new polycyclic diterpenes. Compound 1 showed significant deterrent activity in a fish feeding assay.
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn , Nussallee 6, 53115 Bonn, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Bogdanov
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn , Nussallee 6, 53115 Bonn, Germany.
authors.forename: Cora
authors.initials: C
authors.lastname: Hertzer
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn , Nussallee 6, 53115 Bonn, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Kehraus
authors.affiliation: Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl-von-Ossietzky University Oldenburg , Schleusenstraße 1, 26382 Wilhelmshaven, Germany.
authors.forename: Samuel
authors.initials: S
authors.lastname: Nietzer
authors.affiliation: Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl-von-Ossietzky University Oldenburg , Schleusenstraße 1, 26382 Wilhelmshaven, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Rohde
authors.affiliation: Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl-von-Ossietzky University Oldenburg , Schleusenstraße 1, 26382 Wilhelmshaven, Germany.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Schupp
authors.affiliation: Zoologisches Forschungsmuseum Alexander Koenig , Adenauerallee 160, 53113 Bonn, Germany.
authors.forename: Heike
authors.initials: H
authors.lastname: Wägele
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn , Nussallee 6, 53115 Bonn, Germany.
authors.forename: Gabriele M
authors.initials: GM
authors.lastname: König
mesh_terms: D000818:Animals; D037421:Anthozoa; D001315:Australia; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D049851:Gastropoda / Q000737:chemistry*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011235:Predatory Behavior
chemical_list: C000610217:4-oxochatancin; D004224:Diterpenes