title: [Chromosomal microarray analysis for lateral ventriculomegaly in fetus].
abstract: OBJECTIVE
  To investigate the relationship between fetal lateral ventriculomegaly and chromosomal microarray analysis (CMA) abnormalities.
  
  
  METHODS
  Fifty fetuses with lateral ventriculomegaly detected by ultrasound and a normal karyotype were included. Forty four fetuses were classified as mild ventriculomegaly (MVM), in which the lateral ventricular atrium was 10-15 mm. Six had severe ventriculomegaly (SVM), with the lateral ventricularatrium being ≥ 15 mm. The fetuses were also divided into isolated (n= 21) and non-isolated groups (n= 29) based on whether they are associated with other anomalies.
  
  
  RESULTS
  Thirteen (26%) of the fetuses were found to be abnormal by CMA. For the 44 cases with MVM, 9 (20.9% ) were found to be abnormal, while for the 6 cases with SMV, 4 (66.7%) were found to be abnormal (P>0.05). CMA abnormalities were found in 2 (9.5%) of the 21 fetuses with isolated ventriculomegaly group and 11 (37.9%) of the 29 fetuses with non-isolated ventriculomegaly group (P<0.05).
  
  
  CONCLUSIONS
  Chromosome microdeletions and microduplications are the most common abnormalities found in fetal lateral ventriculomegaly. When ventriculomegaly is associated with other anomalies, the incidence of CMA abnormally is much higher. Prenatal diagnosis is necessary for fetuses with lateral ventriculomegaly.
authors.affiliation: Fetal Medicine Center, Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China. chenbaojiang@126.com.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Xie
authors.forename: Jianzhu
authors.initials: J
authors.lastname: Wu
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Chen
authors.forename: Shaobin
authors.initials: S
authors.lastname: Lin
authors.forename: Yuanjun
authors.initials: Y
authors.lastname: Ji
authors.forename: Weiying
authors.initials: W
authors.lastname: Jiang
authors.forename: Qun
authors.initials: Q
authors.lastname: Fang
authors.forename: Baojiang
authors.initials: B
authors.lastname: Chen
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D058674:Chromosome Duplication; D005260:Female; D005865:Gestational Age; D006801:Humans; D006849:Hydrocephalus / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000235:genetics; D020547:Lateral Ventricles / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000378:metabolism; D046228:Microarray Analysis / Q000379:methods*; D011247:Pregnancy; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal / Q000379:methods*; D055815:Young Adult