title: Salicylic acid derivatives as potential anti asthmatic agents using disease responsive drug delivery system for prophylactic therapy of allergic asthma.
abstract: Asthma is a multi-factorial and complicated lung disorder of the immune system which has expanded to a wider ambit unveiling its etiology to be omnipresent at both ends of the spectrum involving basic pharmacology and in-depth immunology. As asthma occurs through triggered activation of various immune cells due to different stimuli, it poses a great challenge to uncover specific targets for therapeutic interventions. Recent pharmacotherapeutic approaches for asthma have been focused on molecular targeting of transcription factors and their signaling pathways; mainly nucleus factor kappa B (NFκB) and its associated pathways which orchestrate the synthesis of pro-inflammatory cytokines (IL-1β, TNF-α, GM-CSF), chemokines (RANTES, MIP-1a, eotaxin), adhesion molecules (ICAM-1, VCAM-1) and inflammatory enzymes (cyclooxygenase-2 and iNOS). 5-aminosalicylic acid (5-ASA) and sodium salicylate are known to suppress NFκB activation by inhibiting inhibitor of kappa B kinase (IKκB). In order to target the transcription factor, a suitable carrier system for delivering the drug to the intracellular space is essential. 5-ASA and sodium salicylate loaded liposomes incorporated into PEG-4-acrylate and CCRGGC microgels (a polymer formed by crosslinking of trypsin sensitive peptide and PEG-4-acrylate) could probably suit the needs for developing a disease responsive drug delivery system which will serve as a prophylactic therapy for asthmatic patients.
authors.affiliation: Department of Pharmacology, JSS College of Pharmacy, Ootacamund, JSS University, Mysore, Tamilnadu 643001, India. Electronic address: ramasatyanarayanarajuk@gmail.com.
authors.forename: Kalidhindi Rama Satyanarayana
authors.initials: KR
authors.lastname: Raju
authors.affiliation: Department of Pharmacology, JSS College of Pharmacy, Ootacamund, JSS University, Mysore, Tamilnadu 643001, India.
authors.forename: Nilesh S
authors.initials: NS
authors.lastname: Ambhore
authors.affiliation: Department of Pharmacology, JSS College of Pharmacy, Ootacamund, JSS University, Mysore, Tamilnadu 643001, India.
authors.forename: Shashank
authors.initials: S
authors.lastname: Mulukutla
authors.affiliation: Department of Pharmacology, Indore Institute of Pharmacy, Indore, Madhya Pradesh, India.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
authors.forename: Vishakantha
authors.initials: V
authors.lastname: Murthy
authors.affiliation: Department of Dermatology and Allergology, Allergy-Centrum-Charité, CCM, Charité - Universitätsmedizin, Berlin, Germany.
authors.forename: M N Kiran
authors.initials: MN
authors.lastname: Kumar
authors.affiliation: Department of Biochemistry, JSS Medical College, JSS University, Mysore, Karnataka, India.
authors.forename: Subba Rao V
authors.initials: SR
authors.lastname: Madhunapantula
authors.affiliation: Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, JSS University, Mysore, Tamilnadu, India.
authors.forename: Gowthamarajan
authors.initials: G
authors.lastname: Kuppuswamy
authors.affiliation: Department of Pharmacology, JSS College of Pharmacy, Ootacamund, JSS University, Mysore, Tamilnadu 643001, India.
authors.forename: Kannan
authors.initials: K
authors.lastname: Elango
mesh_terms: D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D016503:Drug Delivery Systems; D006801:Humans; D019804:Mesalamine / Q000008:administration & dosage; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D012459:Salicylates / Q000008:administration & dosage*; D015398:Signal Transduction / Q000187:drug effects; D012980:Sodium Salicylate / Q000008:administration & dosage; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D018927:Anti-Asthmatic Agents; D016328:NF-kappa B; D012459:Salicylates; D014409:Tumor Necrosis Factor-alpha; D019804:Mesalamine; D012980:Sodium Salicylate