title: Polyketides from an Endophytic Aspergillus fumigatus Isolate Inhibit the Growth of Mycobacterium tuberculosis and MRSA.
abstract: The crude extract of Aspergillusfumigatus isolate AF3-093A, an endophyte of the brown alga Fucus vesiculosus, showed significant antimicrobial activity in initial bioactivity screens. Bioassay-guided fractionation of the extract led to the isolation of flavipin, chaetoglobosin A and chaetoglobosin B, all of which inhibited the growth of Staphylococcus aureus, methicillin-resistant S. aureus and Mycobacterium tuberculosis H37Ra. The antimycobacterial activity of these compounds has not been previously reported.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Flewelling
authors.forename: Amanda I
authors.initials: AI
authors.lastname: Bishop
authors.forename: John A
authors.initials: JA
authors.lastname: Johnson
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Gray
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000737:chemistry*; D005285:Fermentation; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D061065:Polyketides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D061065:Polyketides