title: [Association between ABO blood groups and coronary heart disease in Chinese Guangxi Zhuang population].
abstract: OBJECTIVE
  To investigate this association between ABO blood groups and coronary heart disease (CHD) in the Chinese Guangxi Zhuang population.
  
  
  METHODS
  From August 2010 to April 2013, we performed a case-control study in a Chinese Zhuang population, which included 1 024 CHD cases and 1 024 age and gender-matched non-CHD controls. The ABO blood groups and biological variables were measured by standard laboratory procedures. The Gensini score was used to evaluate the severity of coronary artery stenosis.
  
  
  RESULTS
  Compared to non-CHD control group, CHD group had higher levels of fasting blood glucose ((6.71 ± 6.72) mmol/L vs. (4.98 ± 1.55) mmol/L, P < 0.001), LDL-C ((2.89 ± 1.18) mmol/L vs. (2.60 ± 1.05) mmol/L, P = 0.002) and CRP ((7.74 ± 7.32) mg/L vs. (2.93 ± 2.19)mg/L, P < 0.001) as well as higher proportion of history of hypertension (57.0% vs. 27.5%, P < 0.001), history of diabetes (29.6% vs. 9.6%, P < 0.001), family history of CHD (35.3% vs. 10.6%, P < 0.001) and smoking (51.0% vs. 38.2%, P < 0.001). Logistic analysis indicated that ABO blood groups were associated with CHD risk in the Chinese Zhuang population. Compared with group O, the group B individuals had a higher risk of CHD (OR = 2.33, 95% CI 1.88-2.90, P < 0.001), this result remained after adjustment for the conventional CHD risk factors (OR = 1.55, 95% CI 1.05-2.52, P = 0.047). In addition, there were significant differences of Gensini score between non-O subjects and group O subjects in the CHD group, and MACE at 1-year follow-up was similar between ABO blood groups of CHD individuals.
  
  
  CONCLUSIONS
  ABO blood groups are associated with CHD risk in the Chinese Zhuang population.
authors.affiliation: Department of Cardiology, People's Hospital of Guangxi Autonomous Region, Nanning 530021, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shi
authors.forename: Yingzhong
authors.initials: Y
authors.lastname: Lin
authors.forename: Hairun
authors.initials: H
authors.lastname: Liu
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Ji
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Lu
authors.forename: Zhengde
authors.initials: Z
authors.lastname: Lu
authors.forename: Nengwen
authors.initials: N
authors.lastname: Xu
authors.forename: Jun
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Email: sy99403373@hotmail.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
mesh_terms: D000017:ABO Blood-Group System; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease; D023921:Coronary Stenosis; D003920:Diabetes Mellitus; D006801:Humans; D006973:Hypertension; D012907:Smoking
chemical_list: D000017:ABO Blood-Group System