title: Phenotypic classification of variability of non-syndromic congenital cleft lip and jaw in Vorderwald × Montbéliarde cattle.
abstract: BACKGROUND
  Non-syndromic congenital cleft lip and jaw (CLJ) is a condition reported in several cattle breeds, but a detailed classification system does not exist for cattle. The objective of the present study was to describe the phenotypic variability of this orofacial malformation in Vorderwald × Montbéliarde cattle. For this purpose, a classification system of CLJ was developed on examination of five orofacial structures: (1) lips, (2) the processus (proc.) nasalis of the os incisivum, (3) the dental plate with adjacent segments of the hard palate, (4) the facial bones (os incisivum, os maxillare, os nasale and os palatinum) and (5) the mandibles. Each structure was given a score reflecting the degree of the lesion from absent (score 0) to severe.
  
  
  RESULTS
  Nine cases were included in the study and they shared absence of the abaxial rostral part of the processus (proc.) nasalis of the os incisivum, partial loss of the rugae palatinae and the dental plate. A sigmoid curvature of the rostral lower jaw as well as a lateral deviation of the face and rostral lower jaw was highly variable in their expression. These deformations were present in eight of nine cases. In addition to the complete CLJ, three animals had an incomplete CLJ on the contralateral site with variable defects of the rostral part of the proc. nasalis of the os incisivum.
  
  
  CONCLUSIONS
  A complete CLJ is obviously accompanied by a loss of parts of the proc. nasalis of the os incisivum. Extent and localization of the missing parts of the proc. nasalis were similar in all cases. A precise classification of the various CLJ forms is necessary.
authors.affiliation: University of Veterinary Medicine Hannover, Foundation, Institute for Animal Breeding and Genetics, Bünteweg 17p, 30559, Hannover, Germany. sina.reinartz@tiho-hannover.de.
authors.forename: Sina
authors.initials: S
authors.lastname: Reinartz
authors.affiliation: University of Veterinary Medicine Hannover, Foundation, Clinic for Horses, Bünteweg 9, 30559, Hannover, Germany. maren.hellige@tiho-hannover.de.
authors.forename: Maren
authors.initials: M
authors.lastname: Hellige
authors.affiliation: University of Veterinary Medicine Hannover, Foundation, Clinic for Horses, Bünteweg 9, 30559, Hannover, Germany. karsten.feige@tiho-hannover.de.
authors.forename: Karsten
authors.initials: K
authors.lastname: Feige
authors.affiliation: University of Veterinary Medicine Hannover, Foundation, Clinic for Cattle, Bischofsholer Damm 15, 30173, Hannover, Germany. peter.wenning@tiho-hannover.de.
authors.forename: Peter
authors.initials: P
authors.lastname: Wenning
authors.affiliation: University of Veterinary Medicine Hannover, Foundation, Institute for Animal Breeding and Genetics, Bünteweg 17p, 30559, Hannover, Germany. ottmar.distl@tiho-hannover.de.
authors.forename: Ottmar
authors.initials: O
authors.lastname: Distl
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000145:classification* / Q000209:etiology / Q000473:pathology; D002971:Cleft Lip / Q000145:classification / Q000209:etiology / Q000473:pathology; D005260:Female; D007569:Jaw Abnormalities / Q000145:classification* / Q000209:etiology / Q000473:pathology; D008297:Male