title: Association Between NAT2 Polymorphisms and Lung Cancer Susceptibility.
abstract: To further investigate the association between NAT2 polymorphisms and lung cancer susceptibility.In terms of phenotypes, we investigated the acetylator status of NAT2 polymorphisms associated with lung cancer risk. Additionally, in view of genotypes, we mainly analyzed 5 single nucleotide polymorphisms (SNPs) in NAT2 gene, namely C282T, A803G, C481T, G590A, and G857A. Twenty-six eligible studies were included in our meta-analysis by searching PubMed, Embase, and CNKI databases. We used odds ratios (ORs) with corresponding 95% confidence intervals (CIs) to evaluate the susceptibility to lung cancer associated with NAT2 polymorphisms.Overall, based on phenotypes, the pooled ORs showed no significant association between NAT2 polymorphisms and lung cancer susceptibility. In the subgroup analyses by ethnicity and source of control, there was still no significant association. In terms of genotypes, overall, no obvious relationship was observed between NAT2 polymorphisms and lung cancer risk. But increased risk of lung cancer was found in association with NAT2 C282T polymorphism (TT vs. CC + TC: OR = 1.58, 95% CI = 1.11-2.25).Our meta-analysis demonstrates that TT genotype in NAT2 C282T polymorphism may be a risk factor for lung cancer susceptibility. Additionally, the acetylator status of 5 SNPs in NAT2 gene may not be associated with lung cancer risk.
authors.affiliation: From the Department of Medical Oncology, The Military General Hospital of Beijing PLA, Beijing, China (CL, LW, XR, JJ, YL, XJ, XZ); Department of General Surgery, The Military General Hospital of Beijing PLA, Beijing, China (WC); and Department of Dermatology, The Military General Hospital of Beijing PLA, Beijing, China (LC).
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.forename: Lin
authors.initials: L
authors.lastname: Cong
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Xinjian
authors.initials: X
authors.lastname: Ruan
authors.forename: Jia
authors.initials: J
authors.lastname: Jia
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Jia
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
mesh_terms: D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment
chemical_list: D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human