title: Adoptive Immunotherapy For Leukemia With Ex vivo Expanded T Cells.
abstract: The development of novel T cell therapies to target leukemia has facilitated the translation of this approach for hematologic malignancies. Different methods of manufacturing leukemia-specific T cells have evolved, along with additional measures to increase the safety of this therapy. This is an overview of expanded T cell therapeutics with a focus on how the manufacturing strategies have been refined, and where the research is heading.
authors.forename: Conrad R Y
authors.initials: CR
authors.lastname: Cruz
authors.affiliation: Program for Cell Enhancement and Technologies for Immunotherapy (CETI), Children's National Health System, Washington, DC 20010, United States.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Bollard
mesh_terms: D018929:Cell Culture Techniques; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D002986:Clinical Trials as Topic; D006801:Humans; D016219:Immunotherapy, Adoptive; D007938:Leukemia / Q000276:immunology / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation*
keywords: Cell therapy; ex vivo expanded T cells.; leukemia antigens