title: IL-8 and VEGFR-2 polymorphisms modulate long-term functional response to intravitreal ranibizumab in exudative age-related macular degeneration.
abstract: OBJECTIVE
  To investigate possible associations between VEGFR-2 and IL-8 gene SNPs and 1-year response to intravitreal ranibizumab for exudative age-related macular degeneration.
  
  
  METHODS
  Sixty-four eyes underwent a loading phase of three monthly intravitreal injections of ranibizumab 0.5 mg/0.05 ml followed by Pro Re Nata retreatment. VEGFR-2 rs2071559 (-604 A/G) and IL-8 rs4073 (-251 A/T) were analyzed.
  
  
  RESULTS
  Ranibizumab was significantly more effective as measured by visual acuity in patients harboring the IL-8 rs4073 TT genotype (p = 0.045), whereas patients carrying the VEGFR-2 rs2071559 CC genotype revealed better functional response as measured by mean retinal sensitivity (p = 0.034).
  
  
  CONCLUSIONS
  IL-8 rs4073 and VEGFR-2 rs2071559 genotypes may represent important molecular determinants to modulate final outcomes in neovascular age-related macular degeneration patients.
authors.affiliation: Ophthalmology Unit, University of Pisa, Pisa, Italy.|Fondazione G. B. Bietti, IRCCS Rome, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Lazzeri
authors.affiliation: Division of Pharmacology, Department of Clinical & Experimental Medicine, University of Pisa, Pisa, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Orlandi
authors.affiliation: Department of Endocrinology & Metabolism, University of Pisa, Pisa, Italy.|Department of Energy & Systems Engineering, University of Pisa, Pisa, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Piaggi
authors.affiliation: Ophthalmology Unit, University of Pisa, Pisa, Italy.
authors.forename: Maria Sole
authors.initials: MS
authors.lastname: Sartini
authors.affiliation: Ophthalmology Unit, University of Pisa, Pisa, Italy.
authors.forename: Giamberto
authors.initials: G
authors.lastname: Casini
authors.affiliation: Ophthalmology Unit, University of Pisa, Pisa, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Guidi
authors.affiliation: Ophthalmology Unit, University of Pisa, Pisa, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Figus
authors.affiliation: Division of Pharmacology, Department of Clinical & Experimental Medicine, University of Pisa, Pisa, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Fioravanti
authors.affiliation: Division of Pharmacology, Department of Clinical & Experimental Medicine, University of Pisa, Pisa, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Di Desidero
authors.affiliation: Fondazione G. B. Bietti, IRCCS Rome, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Ripandelli
authors.affiliation: Fondazione G. B. Bietti, IRCCS Rome, Italy.
authors.forename: Mariacristina
authors.initials: M
authors.lastname: Parravano
authors.affiliation: Fondazione G. B. Bietti, IRCCS Rome, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Varano
authors.affiliation: Ophthalmology Unit, University of Pisa, Pisa, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Nardi
authors.affiliation: Division of Pharmacology, Department of Clinical & Experimental Medicine, University of Pisa, Pisa, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Bocci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005584:Fovea Centralis / Q000187:drug effects / Q000473:pathology; D005838:Genotype; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics*; D058449:Intravitreal Injections; D008268:Macular Degeneration / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D000069579:Ranibizumab / Q000627:therapeutic use*; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000235:genetics*
chemical_list: D020533:Angiogenesis Inhibitors; D016209:Interleukin-8; D042461:Vascular Endothelial Growth Factor A; D040301:Vascular Endothelial Growth Factor Receptor-2; D000069579:Ranibizumab
keywords: IL-8; SNPs; VEGF-2; age-related macular degeneration; pharmacogenetics; ranibizumab