title: The Role of Neuropeptides in Mouse Models of Colitis.
abstract: Inflammatory bowel disease (IBD) constitutes an important clinically significant condition that results in morbidity and mortality. IBD can be generally classified into either ulcerative colitis (UC) or Crohn's disease (CD) that differs in the clinical and histopathology. The role of neuropeptides in the pathogenesis of these conditions is becoming increasingly recognized for their importance in modulating the inflammatory state. Animal models provide the greatest insight to better understand the pathophysiology of both disorders which will hopefully allow for improved treatment strategies. This review will provide a better understanding of the role of murine models for studying colitis.
authors.affiliation: Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.
authors.forename: David
authors.initials: D
authors.lastname: Padua
authors.affiliation: Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.|Divisions of Pulmonary and Critical Care, Department of Veterans Affairs, VA Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Vu
authors.affiliation: Divisions of Pulmonary and Critical Care, Department of Veterans Affairs, VA Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, USA.
authors.forename: Patrizia M
authors.initials: PM
authors.lastname: Germano
authors.affiliation: Division of Gastroenterology, Hepatology and Parenteral Nutrition, Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA. jpisegna@ucla.edu.|David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. jpisegna@ucla.edu.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Pisegna
mesh_terms: D000818:Animals; D003093:Colitis, Ulcerative / Q000209:etiology / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016264:Dextran Sulfate / Q000633:toxicity; D004195:Disease Models, Animal; D017353:Gene Deletion; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism*; D014302:Trinitrobenzenesulfonic Acid / Q000633:toxicity
chemical_list: D009479:Neuropeptides; D014302:Trinitrobenzenesulfonic Acid; D016264:Dextran Sulfate
keywords: Gastric acid secretion; Gastrin; Gastrointestinal hormones; Pituitary adenylate cyclase-activating polypeptide (PACAP); Vasoactive intestinal polypeptide (VIP)