title: MEDITERRANEAN DIET IS ASSOCIATED WITH LIVER HISTOLOGY IN PATIENTS WITH NON ALCOHOLIC FATTY LIVER DISEASE.
abstract: BACKGROUND
  clinical data on impact of the Mediterranean diet on the the stage of non alcoholic fatty liver disease are limited and these studies have heterogeneous designs.
  
  
  OBJECTIVE
  we decide to explore any potential associations between adherence to the Mediterranean diet and histological characteristics of patients with NAFLD.
  
  
  METHODS
  a sample of 82 patients was analyzed in a cross sectional study. To evaluate the level of adherence to the Mediterranean dietary pattern the 14-Item Mediterranean Diet Assessment Tool was used.
  
  
  RESULTS
  thirty five patients (42.7%) had a low grade of steatosis (grade 1 of classification) and 47 patients (57.3%) had a high grade of steatosis (grade 2 and 3). Fifty-six patients (68.3%) had liver steatohepatitis and forty-two patients (51.2%) had liver fibrosis. In the logistic regresion analysis, one unit of the 14-Item Mediterranean Diet Assessment Tool was associated with a lower likehood of having steatohepatitis odds ratio 0.43 (CI:95%: 0.29-0.64) and steatosis 0.42 (CI:95%: 0.26- 0.70). Secondly, one unit of HOMA-IR was associated with higher likehood of having steatosis odds ratio 2.01 (CI:95%: 1.08-3.71) and liver fibrosis 1.38 (CI:95%: 1.10-1.80) .
  
  
  CONCLUSIONS
  greater adherence to the Mediterranean diet was associated with lower likelihood of high grade of steatosis and presence of steatohepatitis.
authors.affiliation: Center of Investigation of Endocrinology and Nutrition, Medicine School. Dept Gastroenterology and Hepatology.. dadluis@yahoo.es.
authors.forename: Rocio
authors.initials: R
authors.lastname: Aller
authors.affiliation: Center of Investigation of Endocrinology and Nutrition, Medicine School. Dept of Endocrinology and Nutrition. Hospital Clínico Universitario. University of Valladolid, Valladolid, Spain.. dadluis@yahoo.es.
authors.forename: Olatz
authors.initials: O
authors.lastname: Izaola
authors.affiliation: Center of Investigation of Endocrinology and Nutrition, Medicine School.. dadluis@yahoo.es.
authors.forename: Beatriz
authors.initials: B
authors.lastname: de la Fuente
authors.affiliation: Center of Investigation of Endocrinology and Nutrition, Medicine School. Dept of Endocrinology and Nutrition. Hospital Clínico Universitario. University of Valladolid, Valladolid, Spain.. dadluis@yahoo.es.
authors.forename: Daniel Antonio
authors.initials: DA
authors.lastname: De Luis Román
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D038441:Diet, Mediterranean; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000473:pathology*; D010349:Patient Compliance