title: Preparation and Evaluation of Contact Lenses Embedded with Polycaprolactone-Based Nanoparticles for Ocular Drug Delivery.
abstract: To improve the efficiency of topical ocular drug administration, we focused on development of a nanoparticles loaded contact lens to deliver the hydrophobic drug over a prolonged period of time. The cross-linked nanoparticles based on PCL (poly ε-caprolactone), 2-hydroxy ethyl methacrylate (HEMA), and poly ethylene glycol diacrylate (PEG-DA) were prepared by surfactant-free miniemulsion polymerization. The lens material was prepared through photopolymerization of HEMA and N-vinylpyrrolidone (NVP) using PEG-DA as the cross-linker. Effects of nanoparticles loading on critical contact lens properties such as transparency, water content, modulus and ion and oxygen permeabilities were studied. Nanoparticles and hydrogel showed high viability, indicating the absence of cytotoxicity and stimulatory effect. Drug release studies revealed that the hydrogel embedded with nanoparticles released the drug for a period of 12 days. The results of this study provide evidence that nanoparticles loaded hydrogels could be used for extended delivery of loteprednol etabonate and perhaps other drugs.
authors.affiliation: Polymer Laboratory, Chemistry Department, School of Science, University of Tehran , P.O. Box 14155-6455, Tehran, Iran.
authors.forename: Farzaneh Hashemi
authors.initials: FH
authors.lastname: Nasr
authors.affiliation: Polymer Laboratory, Chemistry Department, School of Science, University of Tehran , P.O. Box 14155-6455, Tehran, Iran.
authors.forename: Sepideh
authors.initials: S
authors.lastname: Khoee
authors.affiliation: Institute of Biomedical Research, Faculty of Veterinary Medicine, University of Tehran , Tehran, Iran.
authors.forename: Mohammad Mehdi
authors.initials: MM
authors.lastname: Dehghan
authors.affiliation: Institute of Biomedical Research, Faculty of Veterinary Medicine, University of Tehran , Tehran, Iran.
authors.forename: Sirous Sadeghian
authors.initials: SS
authors.lastname: Chaleshtori
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences , Tehran 14176, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000818:Animals; D002470:Cell Survival; D002478:Cells, Cultured; D003261:Contact Lenses; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004847:Epithelial Cells / Q000187:drug effects / Q000502:physiology; D019573:Epithelium, Corneal; D005260:Female; D020100:Hydrogels / Q000737:chemistry / Q000633:toxicity; D000069559:Loteprednol Etabonate / Q000737:chemistry; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D010100:Oxygen / Q000737:chemistry; D010316:Particle Size; D010539:Permeability; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011817:Rabbits; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D020100:Hydrogels; D008689:Methacrylates; D011091:Polyesters; C016240:polycaprolactone; D011092:Polyethylene Glycols; C005044:hydroxyethyl methacrylate; D010100:Oxygen; D000069559:Loteprednol Etabonate