title: Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum.
abstract: One new eremophilane-type sesquiterpene (1, citreopenin) was isolated from Penicillium citreonigrum (HQ738282), and the structure was elucidated by a combination of spectroscopic data interpretation and single-crystal X-ray diffraction analysis using Cu Kα radiation (CCDC 1030588). Compound 1 showed weak activity against KB-VIN (IC50 = 11.0 ± 0.156 μM), while the known compound 3 exhibited selective cytotoxicity against MDA-MB-231 triple-negative breast cancer (TNBC) (IC50 = 5.42 ± 0.167 μM).
authors.affiliation: a Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province , Jiangsu Normal University , Xuzhou 221116 , China.|b Natural Product Research Laboratories, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , NC 27599-7568 , USA.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Yuan
authors.affiliation: b Natural Product Research Laboratories, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , NC 27599-7568 , USA.
authors.forename: Masuo
authors.initials: M
authors.lastname: Goto
authors.affiliation: b Natural Product Research Laboratories, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , NC 27599-7568 , USA.|c Natural Products Research Institute, Kaohsiung Medical University , Kaohsiung , Taiwan.
authors.forename: Kan-Yen
authors.initials: KY
authors.lastname: Hsieh
authors.affiliation: a Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province , Jiangsu Normal University , Xuzhou 221116 , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yuan
authors.affiliation: b Natural Product Research Laboratories, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , NC 27599-7568 , USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: b Natural Product Research Laboratories, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , NC 27599-7568 , USA.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Morris-Natschke
authors.affiliation: b Natural Product Research Laboratories, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , NC 27599-7568 , USA.|d Chinese Medicine Research and Development Center , China Medical University and Hospital , Taichung , Taiwan.
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C000607480:citreopenin
keywords: Metabolites; Penicillium citreonigrum; cytotoxic; eremophilane-type sesquiterpene