title: Prognostic role of sex steroid receptors in pancreatic adenocarcinoma.
abstract: From the available literature, it is unclear what proportion of pancreatic adenocarcinomas express estrogen receptors (ERα, ERβ), progesterone receptors (PR), and androgen receptors (AR), and if any of these markers have prognostic significance. We aimed to assess (1) the expression and (2) the correlation of the aforementioned markers with clinicopathological parameters and prognosis in patients with pancreatic adenocarcinoma. During a five-year period, 60 patients with pancreatic ductal adenocarcinoma underwent surgical resection at a single institution. Immunohistochemical stains of the studied markers were quantified by Image analysis system. ERα expression was positively associated with PR expression. Moreover, ERβ was inversely associated with the presence of metastases, whereas no significant associations implicated AR. As far as the prognostic significance of the studied receptors is concerned, higher ERα expression correlated with poorer survival at the univariate analysis, but the finding dissipated at the multivariate approach. No significant associations with overall survival were noted regarding the other receptors. The role of sex hormone receptors in the survival from pancreatic adenocarcinoma seems rather limited. Further prospective studies assessing those receptors should ideally be designed in order to confirm our results and possibly outline additional correlations between other steroid receptors and features of pancreatic adenocarcinoma.
authors.affiliation: 3rd Surgical Clinic of George Gennimatas General Hospital, Mesogeion Ave 154, 156 69 Athens, Greece. Electronic address: dcgeorgiadou@gmail.com.
authors.forename: Despoina
authors.initials: D
authors.lastname: Georgiadou
authors.affiliation: Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, M. Asias 75, Goudi, Athens, 11527, Greece.
authors.forename: Theodoros N
authors.initials: TN
authors.lastname: Sergentanis
authors.affiliation: Department of Pathology, National and Kapodistrian University of Athens, Mikras Asias 75, 11527 Athens, Greece.
authors.forename: Stratigoula
authors.initials: S
authors.lastname: Sakellariou
authors.affiliation: Department of Forensic Pathology and Toxicology, Medical School, University of Athens, Mikras Asias 75, 11527 Athens, Greece.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Vlachodimitropoulos
authors.affiliation: Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, M. Asias 75, Goudi, Athens, 11527, Greece.
authors.forename: Theodora
authors.initials: T
authors.lastname: Psaltopoulou
authors.affiliation: Department of Pathology, National and Kapodistrian University of Athens, Mikras Asias 75, 11527 Athens, Greece.
authors.forename: Andreas C
authors.initials: AC
authors.lastname: Lazaris
authors.affiliation: Research Center, Hellenic Anticancer Institute, 11 Valtetsiou St., Athens 10680, Greece Athens, Greece.
authors.forename: Antonia
authors.initials: A
authors.lastname: Gounaris
authors.affiliation: 1st Department of Propaedeutic Surgery, Hippokratio Hospital, Vassilissis Sophias Avenue 114, 115 27 Athens, Greece.
authors.forename: George C
authors.initials: GC
authors.lastname: Zografos
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000378:metabolism*; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D011379:Prognosis; D011446:Prospective Studies; D011944:Receptors, Androgen / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*
chemical_list: D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
keywords: Image analysis; Pancreatic adenocarcinoma; Sex steroid hormones