title: Matrices for combined delivery of proteins and synthetic molecules.
abstract: With the increasing advancement of synergistic, multimodal approaches to influence the treatment of infectious and non-infectious diseases, we witness the development of enabling techniques merging necessary complexity with leaner designs and effectiveness. Systems- and polypharmacology ask for multi-potent drug combinations with many targets to engage with the biological system. These demand drug delivery designs for one single drug, dual drug release systems and multiple release matrices in which the macromolecular structure allows for higher solubilization, protection and sequential or combined release profiles. As a result, nano- and micromaterials have been evolved from mono- to dual drug carriers but are also an essential part to establish multimodality in polymeric matrices. Surface dynamics of particles creating interfaces between polymer chains and hydrogels inspired the development not only of biomedical adhesives but also of injectable hydrogels in which the nanoscale material is both, adhesive and delivery tool. These complex delivery systems are segmented into two delivery subunits, a polymer matrix and nanocarrier, to allow for an even higher tolerance of the incorporated drugs without adding further synthetic demands to the nanocarrier alone. The opportunities in these quite novel approaches for the delivery of small and biological therapeutics are remarkable and selected examples for applications in cancer and bone treatments are discussed.
authors.affiliation: Department of Chemistry, Vanderbilt University, 7665 Stevenson Center, Nashville, TN 37235, USA.
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Gilmore
authors.affiliation: Department of Chemistry, Vanderbilt University, 7665 Stevenson Center, Nashville, TN 37235, USA.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Lampley
authors.affiliation: Australian Centre for Nanomedicine (ACN), School of Chemical Sciences and Engineering, University of NSW, Australia. Electronic address: cboyer@unsw.edu.au.
authors.forename: Cyrille
authors.initials: C
authors.lastname: Boyer
authors.affiliation: Department of Chemistry, Vanderbilt University, 7665 Stevenson Center, Nashville, TN 37235, USA. Electronic address: eva.harth@vanderbilt.edu.
authors.forename: Eva
authors.initials: E
authors.lastname: Harth
mesh_terms: D000818:Animals; D004338:Drug Combinations; D016503:Drug Delivery Systems; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry; D011506:Proteins / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D004338:Drug Combinations; D020100:Hydrogels; D004364:Pharmaceutical Preparations; D011108:Polymers; D011506:Proteins
keywords: Combined delivery; Hydrogels; Nanoassemblies; Nanogels; Polymer matrices