title: Plasma radiometabolite correction in dynamic PET studies: Insights on the available modeling approaches.
abstract: Full kinetic modeling of dynamic PET images requires the measurement of radioligand concentrations in the arterial plasma. The unchanged parent radioligand must, however, be separated from its radiometabolites by chromatographic methods. Thus, only few samples can usually be analyzed and the resulting measurements are often noisy. Therefore, the measurements must be fitted with a mathematical model. This work presents a comprehensive analysis of the different models proposed in the literature to describe the plasma parent fraction (PPf) and of the alternative approaches for radiometabolite correction. Finally, we used a dataset of [(11)C]PBR28 brain PET data as a case study to guide the reader through the PPf model selection process.
authors.affiliation: Department of Information Engineering, University of Padova, Padova, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Tonietto
authors.affiliation: Department of Information Engineering, University of Padova, Padova, Italy.
authors.forename: Gaia
authors.initials: G
authors.lastname: Rizzo
authors.affiliation: Department of Neuroimaging, IoPPN, King's College London, London, UK.
authors.forename: Mattia
authors.initials: M
authors.lastname: Veronese
authors.affiliation: Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Fujita
authors.affiliation: Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA.
authors.forename: Sami S
authors.initials: SS
authors.lastname: Zoghbi
authors.affiliation: Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA INCIA UMR-CNRS 5287, Université de Bordeaux, Bordeaux, France.
authors.forename: Paolo
authors.initials: P
authors.lastname: Zanotti-Fregonara
authors.affiliation: Department of Information Engineering, University of Padova, Padova, Italy bertoldo@dei.unipd.it.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bertoldo
mesh_terms: D000465:Algorithms; D001711:Biotransformation; D064368:Healthy Volunteers; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008959:Models, Neurological; D008962:Models, Theoretical; D011153:Population; D049268:Positron-Emission Tomography / Q000379:methods* / Q000706:statistics & numerical data*; D011743:Pyrimidines / Q000097:blood / Q000493:pharmacokinetics; D019275:Radiopharmaceuticals / Q000097:blood / Q000493:pharmacokinetics*; D012016:Reference Values
chemical_list: C526315:(methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine; D011743:Pyrimidines; D019275:Radiopharmaceuticals
keywords: PET; PPf modeling; plasma parent fraction; radiometabolite correction