title: Non-coding RNAs in Mammary Gland Development and Disease.
abstract: Non-coding RNAs (ncRNAs) are untranslated RNA molecules that function to regulate the expression of numerous genes and associated biochemical pathways and cellular functions. NcRNAs include small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs). They participate in the regulation of all developmental processes and are frequently aberrantly expressed or functionally defective in disease. This Chapter will focus on the role of ncRNAs, in particular miRNAs and lncRNAs, in mammary gland development and disease.
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia.
authors.forename: Gurveen K
authors.initials: GK
authors.lastname: Sandhu
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia.
authors.forename: Michael J G
authors.initials: MJG
authors.lastname: Milevskiy
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia.
authors.forename: Wesley
authors.initials: W
authors.lastname: Wilson
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia.
authors.forename: Annette M
authors.initials: AM
authors.lastname: Shewan
authors.affiliation: School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia. melissa.brown@uq.edu.au.
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Brown
mesh_terms: D000818:Animals; D001941:Breast Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008321:Mammary Glands, Animal / Q000254:growth & development* / Q000473:pathology; D042361:Mammary Glands, Human / Q000254:growth & development* / Q000473:pathology; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism*
chemical_list: D022661:RNA, Untranslated
keywords: Breast cancer; EMT; Epithelial cell differentiation; Epithelial-stromal interactions; Hormonal regulation; Signalling pathways