title: Synthesis of Chiral β-Amino Nitroalkanes via Rhodium-Catalyzed Asymmetric Hydrogenation.
abstract: The asymmetric hydrogenation of β-amino nitroolefins has been successfully achieved by rhodium/bis(phosphine)-thiourea L1 with excellent enantioselectivities and yields (up to 96% ee, 96% yield, >99% conversion, TON up to 1000) under mild conditions. Chiral β-amino nitroalkane products and their derivatives are versatile intermediates in organic synthesis.
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou, Zhejiang 310014, P. R. China.
authors.forename: Pan
authors.initials: P
authors.lastname: Li
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
authors.affiliation: College of Chemistry & Materials Science, Northwest University , Xuefu Road, Xi'an 710127, P. R. China.
authors.forename: Qingyang
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Weilong
authors.initials: W
authors.lastname: Wu
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology , Hangzhou, Zhejiang 310014, P. R. China.
authors.forename: Xinquan
authors.initials: X
authors.lastname: Hu
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Xiu-Qin
authors.initials: XQ
authors.lastname: Dong
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D015394:Molecular Structure; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010720:Phosphines / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry
chemical_list: D000473:Alkanes; D009574:Nitro Compounds; D010720:Phosphines; D012238:Rhodium; C044646:phosphine; D013890:Thiourea