title: CCL28 Cannot Replace IgE for Severity by Objective SCORAD Index in Atopic Dermatitis in Children.
abstract: BACKGROUND
  Recently, CC chemokine ligand28 (CCL28) has been reported as a severity marker in atopic dermatitis. We studied the association between objectively observed lesions and the level of CCL28 in children patients.
  
  
  METHODS
  A total of 105 children patients were grouped by the objective Scoring Atopic Dermatitis index (SCORAD). Total IgE, specific IgE, complete blood count, and serum level of CCL28 were evaluated.
  
  
  RESULTS
  The mean age of the subjects was 5.3 (range, 0 - 12 years). The median SCORAD was 21.4 and consisted of mild 70%, moderate 25%, and severe 6% disease. There were no statistical differences among severity groups for CCL28 or for total IgE. Total IgE showed positive correlation with eosinophil count (r = 0.429, p < 0.01), and SCORAD (r = 0.210, p < 0.05).
  
  
  CONCLUSIONS
  The disease severity of atopic dermatitis in children is not correlated to the level of CCL28, but rather related to that of total IgE.
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Yoon
authors.forename: Youngwon
authors.initials: Y
authors.lastname: Nam
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Song
authors.forename: Eun Youn
authors.initials: EY
authors.lastname: Roh
authors.forename: Hyun-Sun
authors.initials: HS
authors.lastname: Yoon
authors.forename: Sue
authors.initials: S
authors.lastname: Shin
mesh_terms: D019742:Chemokines, CC / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000378:metabolism*; D004485:Eczema / Q000097:blood; D004804:Eosinophils / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D007231:Infant, Newborn; D007958:Leukocyte Count; D008297:Male; D056910:Republic of Korea; D012720:Severity of Illness Index
chemical_list: C414047:CCL28 protein, human; D019742:Chemokines, CC; D007073:Immunoglobulin E