title: A Rare Case of Nonsecretory Multiple Myeloma in Lagos, Nigeria: A Case Report and Literature Review.
abstract: Multiple myeloma (MM) is a plasma cell disorder associated with clonal proliferation of plasma cells. Nonsecretory multiple myeloma (NSMM) is a rare variant of MM and accounts for approximately 1% to 5% of all cases. It is defined as symptomatic myeloma without detectable monoclonal immunoglobulin on serum or urine electrophoresis. This variant usually poses a diagnostic challenge to the clinician. We present a 60-year-old Nigerian man who was investigated extensively for bone pain, weight loss, and anaemia. He was eventually diagnosed as having nonsecretory multiple myeloma based on histology and immunohistochemistry results of bone marrow trephine biopsy. He is currently being managed with bortezomib, doxorubicin, and thalidomide, as well as zoledronic acid. He is also on anticoagulation. He continues to show remarkable clinical improvement. We describe this case report and literature review for better awareness amongst medical practitioners and pathologists.
authors.affiliation: Department of Haematology and Blood Transfusion, Lagos State University College of Medicine, Ikeja, Nigeria.
authors.forename: Ebele
authors.initials: E
authors.lastname: Uche
authors.affiliation: Department of Haematology and Blood Transfusion, Lagos State University College of Medicine, Ikeja, Nigeria.
authors.forename: Akinsegun
authors.initials: A
authors.lastname: Akinbami
authors.affiliation: Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria.
authors.forename: Sarah
authors.initials: S
authors.lastname: John-Olabode
authors.affiliation: Department of Haematology and Blood Transfusion, Lagos State University College of Medicine, Ikeja, Nigeria.
authors.forename: Adedoyin
authors.initials: A
authors.lastname: Dosunmu
authors.affiliation: School of Life and Health Sciences, Aston University, Birmingham, UK.
authors.forename: Majeed
authors.initials: M
authors.lastname: Odesanya