title: Necrotizing crescentic glomerulonephritis related to sarcoidosis: a case report.
abstract: BACKGROUND
  Renal injury due to sarcoidosis develops in less than a quarter of patients with this systemic disease. In most cases, granulomatous tissue alters the production of vitamin D, which leads to hypercalciuria, nephrocalcinosis, and nephrolithiasis. Granulomatous interstitial nephritis is another well-recognized pathological process associated with sarcoidosis. However, a glomerular pathology is very rarely noted, and only a few cases are reported to have cellular crescentic glomerulonephritis.
  
  
  METHODS
  We describe the case of a 26-year-old African American woman with systemic sarcoidosis, with a unique constellation of renal lesions, including noncaseating epithelioid granulomatous necrotizing interstitial nephritis, cellular crescent formation, and necrotizing vasculitis. Immunosuppressive therapy was helpful for alleviating her nephrotic syndrome and maintaining the stability of her renal function over a 30-month period.
  
  
  CONCLUSIONS
  Glomerular involvement of sarcoidosis needs to be considered in the differential diagnosis in cases of rapidly progressive glomerular nephritis.
authors.affiliation: Renal Physicians Inc., One Elizabeth Place, Suite 190, Dayton, OH, 45418, USA. natallia.maroz@wright.edu.|Department of Medicine, Wright State University, Boonshoft School of Medicine, 128 E. Apple St., 2nd Floor, Dayton, OH, 45409, USA. natallia.maroz@wright.edu.|Department of Medicine, Kettering Medical Center, 3535 Southern Blvd Kettering, Dayton, OH, 45429, USA. natallia.maroz@wright.edu.
authors.forename: Natallia
authors.initials: N
authors.lastname: Maroz
authors.affiliation: Department of Medicine, Kettering Medical Center, 3535 Southern Blvd Kettering, Dayton, OH, 45429, USA. halle.field@gmail.com.
authors.forename: Halle
authors.initials: H
authors.lastname: Field
mesh_terms: D000328:Adult; D001741:Black or African American; D001379:Azathioprine / Q000008:administration & dosage*; D003404:Creatinine / Q000097:blood; D005260:Female; D005534:Foot Diseases / Q000209:etiology*; D005921:Glomerulonephritis / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D033162:Incidental Findings; D010146:Pain / Q000209:etiology*; D011241:Prednisone / Q000008:administration & dosage*; D011507:Proteinuria / Q000209:etiology; D012507:Sarcoidosis / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003404:Creatinine; D001379:Azathioprine; D011241:Prednisone