title: Increased humoral antibody response of foot-and-mouth disease virus vaccine in growing pigs pre-treated with poly-γ-glutamic acid.
abstract: This study was conducted to determine if humoral antibody response of foot-and-mouth disease (FMD) vaccine improved in 8-week-old growing pigs born to well-vaccinated sows pre-treated with 60 mg of poly-γ-glutamic acid (γ-PGA) three days before vaccination. Antibody against FMD virus serotype O was measured 0, 2, 4 and 6 weeks post-vaccination, using a PrioCHECK FMDV type O ELISA kit. The results showed that positive antibody reactions against FMDV serotype O antigen among a component of the vaccine significantly increased in response to pre-injection with γ-PGA.
authors.affiliation: Department of Veterinary Medicine Virology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Koreaiversity, Seoul 08826, Korea.
authors.forename: Jee-Hoon
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Veterinary Medicine Virology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Koreaiversity, Seoul 08826, Korea.
authors.forename: Ik-Jae
authors.initials: IJ
authors.lastname: Kang
authors.affiliation: Department of Veterinary Medicine Virology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Koreaiversity, Seoul 08826, Korea.
authors.forename: A-Reum
authors.initials: AR
authors.lastname: Kim
authors.affiliation: Department of Veterinary Medicine Virology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Koreaiversity, Seoul 08826, Korea.
authors.forename: You-Sun
authors.initials: YS
authors.lastname: Noh
authors.affiliation: Department of Veterinary Medicine Virology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Koreaiversity, Seoul 08826, Korea.
authors.forename: Hee-Chun
authors.initials: HC
authors.lastname: Chung
authors.affiliation: Department of Veterinary Medicine Virology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Koreaiversity, Seoul 08826, Korea.
authors.forename: Bong-Kyun
authors.initials: BK
authors.lastname: Park
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D005536:Foot-and-Mouth Disease / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D029544:Foot-and-Mouth Disease Virus / Q000276:immunology*; D056724:Immunity, Humoral / Q000187:drug effects; D007155:Immunologic Factors / Q000008:administration & dosage / Q000494:pharmacology; D011099:Polyglutamic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D014611:Vaccination / Q000662:veterinary*; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007155:Immunologic Factors; D014765:Viral Vaccines; C511775:poly(gamma-glutamic acid); D011099:Polyglutamic Acid
keywords: foot-and-mouth disease virus vaccine; humoral immune response; poly-γ-glutamic acid