title: A new sesquiterpenoid from Polyalthia petelotii.
abstract: A new sesquiterpenoid (‒)-ethyl dihydrophaseate (1) was isolated from the stems and leaves of Polyalthia petelotii, together with two clerodane diterpenoids, 16α-hydroxycleroda-3,13(14)Z-dien-15,16-olide (2), 15-hydroxy-cis-ent-cleroda-3,13(E)-diene (3), a eudesmane sesquiterpenoid, eudesm-4(15)-ene-7α,11-diol (4), an aromatic aldehyde, vanillin (5), a bisisoquinolines alkaloid, spinosine (6) and an aporphine alkaloid, (‒)-oliveroline-β-N-oxide (7). Their structures were established by extensive spectroscopic analysis, including 2D-NMR techniques. Compounds 3, 4 and 6 were isolated from the genus Polyalthia for the first time and the others obtained originally from P. petelotii. The isolates were assessed for their cytotoxicity against five human tumour lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that only 2 displayed weak inhibitory activity.
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Kunming , China.
authors.forename: Caiqiong
authors.initials: C
authors.lastname: Yang
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Kunming , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Peng
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Kunming , China.
authors.forename: Bijuan
authors.initials: B
authors.lastname: Yang
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Kunming , China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Kunming , China.
authors.forename: Yegao
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002681:China; D045785:Diterpenes, Clerodane / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D031044:Polyalthia / Q000737:chemistry*; D012717:Sesquiterpenes; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane; D012717:Sesquiterpenes; C000617275:ethyl dihydrophaseate
keywords: Annonaceae; Polyalthia petelotii; sesquiterpenoid