title: Advances in the Treatment of Metastatic Prostate Cancer.
abstract: During the past several years, there has been substantial progress in the development of treatments for advanced prostate cancer with the approval of multiple new life-prolonging agents using different mechanisms of action. Such progress was attainable because of advances in our understanding of the biology behind mechanisms of androgen receptor pathway activation, complex tumor-microenvironment interaction of bone metastasis, antitumor immunology, and new oncogenic pathways. Continuous efforts are being made to develop new therapeutics with novel mechanisms of action, define the optimal sequences and/or combinations of current agents, and identify reliable surrogate end points to facilitate new drug development.
authors.affiliation: Genito-Urinary Oncology Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University, Baltimore, MD.
authors.forename: Jong Chul
authors.initials: JC
authors.lastname: Park
authors.affiliation: Genito-Urinary Oncology Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University, Baltimore, MD. Electronic address: eisenma@jhmi.edu.
authors.forename: Mario A
authors.initials: MA
authors.lastname: Eisenberger
mesh_terms: D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis / Q000473:pathology* / Q000628:therapy*; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000628:therapy*