title: Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects.
abstract: Ubiquinone (coenzyme Q10, Q10) represents an endogenously synthesized lipid-soluble antioxidant which is crucial for cellular energy production but is diminished with age and under the influence of external stress factors in human skin. Here, it is shown that topical Q10 treatment is beneficial with regard to effective Q10 replenishment, augmentation of cellular energy metabolism, and antioxidant effects. Application of Q10-containing formulas significantly increased the levels of this quinone on the skin surface. In the deeper layers of the epidermis the ubiquinone level was significantly augmented indicating effective supplementation. Concurrent elevation of ubiquinol levels suggested metabolic transformation of ubiquinone resulting from increased energy metabolism. Incubation of cultured human keratinocytes with Q10 concentrations equivalent to treated skin showed a significant augmentation of energy metabolism. Moreover, the results demonstrated that stressed skin benefits from the topical Q10 treatment by reduction of free radicals and an increase in antioxidant capacity.
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Knott
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: Achterberg
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Smuda
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Heiko
authors.initials: H
authors.lastname: Mielke
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Gabi
authors.initials: G
authors.lastname: Sperling
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Dunckelmann
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Vogelsang
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Krüger
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Helge
authors.initials: H
authors.lastname: Schwengler
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Behtash
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Sonja
authors.initials: S
authors.lastname: Kristof
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Heike
authors.initials: H
authors.lastname: Diekmann
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Tanya
authors.initials: T
authors.lastname: Eisenberg
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Berroth
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Janosch
authors.initials: J
authors.lastname: Hildebrand
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Siegner
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Marc
authors.initials: M
authors.lastname: Winnefeld
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Teuber
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Fey
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Janne
authors.initials: J
authors.lastname: Möbius
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Dana
authors.initials: D
authors.lastname: Retzer
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Burkhardt
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Juliane
authors.initials: J
authors.lastname: Lüttke
authors.affiliation: Beiersdorf AG, Research & Development, Hamburg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Blatt
mesh_terms: D000287:Administration, Topical; D000975:Antioxidants / Q000008:administration & dosage* / Q000378:metabolism; D002460:Cell Line; D019587:Dietary Supplements; D004734:Energy Metabolism / Q000187:drug effects*; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000378:metabolism; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D000975:Antioxidants; D014451:Ubiquinone; C024989:coenzyme Q10
keywords: antioxidant; coenzyme Q10; energy metabolism; mitochondrial activity; skin; skin aging; topical Q10 treatment