title: Antibody-targeted biodegradable nanoparticles for cancer therapy.
abstract: The use of nanotechnology has great potentials to revolutionize the future cancer diagnosis and therapy. In this context, various nanoparticles (NPs) have been developed for targeted delivery of diagnostic/therapeutic agents to the tumor sites, which thus result in greater efficacy and much less side effects. The targeting property of NPs is often achieved by functionalizing their surface with tumor-specific ligands, such as antibodies, peptides, small molecules and oligonucleotides. In this review, we will discuss recent progress in the multifunctional design of antibody-targeted NPs with a special focus on liposomal, polymeric and protein-based delivery systems.
authors.affiliation: School of Biomedical Sciences & Pharmacy, Faculty of Health & Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.
authors.forename: Vahid Heravi
authors.initials: VH
authors.lastname: Shargh
authors.affiliation: School of Biomedical Sciences & Pharmacy, Faculty of Health & Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.
authors.forename: Hubert
authors.initials: H
authors.lastname: Hondermarck
authors.affiliation: School of Biomedical Sciences & Pharmacy, Faculty of Health & Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.
authors.forename: Mingtao
authors.initials: M
authors.lastname: Liang
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D006801:Humans; D008081:Liposomes; D053758:Nanoparticles; D009369:Neoplasms / Q000628:therapy*
chemical_list: D000906:Antibodies; D008081:Liposomes
keywords: antibody conjugation; cancer therapy; multifunctional nanoparticles; nanomedicines; targeted delivery