title: Proinflammatory Cytokines Induce XFG Development.
abstract: OBJECTIVE
  To reveal the roles of proinflammatory cytokines within the process of pseudoexfoliation (PEX) production.
  
  
  METHODS
  Our study included 120 patients referred to cataract surgery (early and late stage of pseudoexfoliation syndrome (XFS), pseudoexfoliation glaucoma (XFG), and control group). Serum and humor levels of cytokines were measured in a sample with high sensitivity enzyme-linked immunosorbent assay (ELISA) kit.
  
  
  RESULTS
  Our findings revealed that TNF-α and IL-17, overlooked by IL-6 action in the early stage and in the phase of glaucoma, played the main role in the inflammation activation in the tissue in the early and late stage of XFS and in XFG.
  
  
  CONCLUSIONS
  Local conditions cause chronic inflammation in the eye, subsequently activating fibrotic process with fibrotic tissue deposits in the eye.
authors.affiliation: a Clinic of Ophthalmology , Clinical Center Kragujevac , Kragujevac , Serbia.
authors.forename: Tatjana S
authors.initials: TS
authors.lastname: Sarenac Vulovic
authors.affiliation: b Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences , University of Kragujevac , Kragujevac , Serbia.
authors.forename: Sladjana M
authors.initials: SM
authors.lastname: Pavlovic
authors.affiliation: b Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences , University of Kragujevac , Kragujevac , Serbia.
authors.forename: Nemanja S
authors.initials: NS
authors.lastname: Zdravkovic
mesh_terms: D002387:Cataract Extraction; D016207:Cytokines / Q000097:blood* / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D017889:Exfoliation Syndrome / Q000503:physiopathology*; D005901:Glaucoma / Q000503:physiopathology*; D006801:Humans
chemical_list: D016207:Cytokines
keywords: Cytokines; XFG; XFS; inflammation; pseudoexfoliation