title: The roles of exercise in bone remodeling and in prevention and treatment of osteoporosis.
abstract: With a rapid increase in the aging population, osteoporosis has become a global health problem. Although anti-resorption and anabolic drugs are available, osteoporosis cannot be completely cured. Exercise is an economical, efficacious, and safe way to prevent the development of osteoporosis. Recent studies have investigated the mechanisms by which exercise affects bone remodeling. Here we update the progress made on the effects of exercise on bone cells, including bone marrow mesenchymal stem cells, osteoblasts, osteocytes, and osteoclasts, as well as on bone mass, bone strength, and geometry, hoping to provide a theoretical basis to improve osteoporosis prevention and treatment with exercise.
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, China.
authors.forename: Juanni
authors.initials: J
authors.lastname: Wu
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Guo
authors.affiliation: Shanghai Foreign Language School, Shanghai, China.
authors.forename: Dongchen
authors.initials: D
authors.lastname: Zou
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, China.
authors.forename: Binglin
authors.initials: B
authors.lastname: Chen
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, China.
authors.forename: Zhongguang
authors.initials: Z
authors.lastname: Sun
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Shen
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai, China. Electronic address: zoujun777@126.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Zou
mesh_terms: D000818:Animals; D016723:Bone Remodeling; D001842:Bone and Bones / Q000473:pathology / Q000503:physiopathology; D015444:Exercise; D006801:Humans; D010024:Osteoporosis / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy*
keywords: Exercise; Mechanical loading; Mesenchymal stem cells; Osteoblasts; Osteoclasts; Osteocytes; Osteoporosis