title: Association between MTHFR 677C/T and 1298A/C gene polymorphisms and breast cancer risk.
abstract: We performed a case-control study to investigate the association between single nucleotide polymorphisms in the MTHFR gene (677C/T and 1298A/C) and risk of breast cancer. This case-control study included 216 breast cancer cases and 216 controls. The MTHFR 677C/T and 1298A/C gene polymorphisms were assessed by polymerase chain reaction restriction fragment length polymorphism. We observed an increased likelihood of breast cancer patients having a higher age at menarche and first live birth, and a greater family history of breast cancer, especially among first-degree relatives. In addition, individuals with the TT genotype of MTHFR 677C/T were associated with increased risk of breast cancer by logistic regression analysis; the adjusted odds ratio (95%CI) was 3.05 (1.17-8.87). In conclusion, the results of our study indicated that the MTHFR C677T gene polymorphism could play a role in the development of breast cancer.
authors.affiliation: Department of Breast, Liao Ning Cancer Hospital and Institute, Shenyang, China.
authors.forename: X F
authors.initials: XF
authors.lastname: Zhang
authors.affiliation: Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.
authors.forename: T
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Breast, Liao Ning Cancer Hospital and Institute, Shenyang, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.
authors.forename: S
authors.initials: S
authors.lastname: Li
mesh_terms: D000328:Adult; D000483:Alleles; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)