title: [Comorbidities as risk factors of chronic kidney disease in HIV-infected persons].
abstract: Significant survival prolongation in HIV-infected patients due to effective antiretroviral therapy is connected with increasing prevalence of chronic non-infective diseases in this population, among them chronic kidney disease. The pathogenesis of kidney disease in the setting of HIV includes conditions specific for HIV infection: direct effect of the virus, stage of immunodeficiency and drug toxicity. Chronic comorbidities, such as diabetes mellitus, hypertension, and hyperlipidemia, are additional significant risk factors of kidney disease. In HIV-infected individuals some distinct features of these conditions are observed, which are partly related to the virus and antiretroviral therapy. The article summarizes the effect of comorbidities on kidney function in HIV-infected persons.
authors.affiliation: Pracownia Markerów Nefrotoksyczności Środowiskowej, Katedra i Zakład Toksykologii Uniwersytetu Medycznego im. Piastów Śląskich we Wrocławiu.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Marchewka
authors.affiliation: Katedra i Klinika Chorób Zakaźnych, Chorób Wątroby i Nabytych Niedoborów Odpornościowych, Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Szymczak
authors.affiliation: Katedra i Klinika Chorób Zakaźnych, Chorób Wątroby i Nabytych Niedoborów Odpornościowych, Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu.
authors.forename: Brygida
authors.initials: B
authors.lastname: Knysz
mesh_terms: D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use; D015897:Comorbidity; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000453:epidemiology; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D011044:Poland; D051436:Renal Insufficiency, Chronic / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology*
chemical_list: D019380:Anti-HIV Agents