title: Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of stay and lung injury in patients without acute lung injury.
abstract: BACKGROUND
  During the last decade, there has been a trend towards decreasing tidal volumes for positive pressure ventilation during surgery. It is not known whether this new trend is beneficial or harmful for patients.
  
  
  OBJECTIVE
  To assess the benefit of intraoperative use of low tidal volume ventilation (< 10 mL/kg of predicted body weight) to decrease postoperative complications.
  
  
  METHODS
  We searched the Cochrane Central Register of Controlled Trials (CENTRAL 2014, Issue 9), MEDLINE (OvidSP) (from 1946 to 5 September 2014) and EMBASE (OvidSP) (from 1974 to 5 September 2014).
  
  
  METHODS
  We included all parallel randomized controlled trials (RCTs) that evaluated the effect of low tidal volumes (defined as < 10 mL/kg) on any of our selected outcomes in adult participants undergoing any type of surgery. We did not retain studies with participants requiring one-lung ventilation.
  
  
  METHODS
  Two authors independently assessed the quality of the retained studies with the Cochrane 'Risk of bias' tool. We analysed data with both fixed-effect (I(2) statistic < 25%) or random-effects (I(2) statistic > 25%) models based on the degree of heterogeneity. When there was an effect, we calculated a number needed to treat for an additional beneficial outcome (NNTB) using the odds ratio. When there was no effect, we calculated the optimal size information.
  
  
  RESULTS
  We included 12 studies in the review. In total these studies detailed 1012 participants (499 participants in the low tidal volume group and 513 in the high volume group). All studies included were at risk of bias as defined by the Cochrane tool. Based on nine studies including 899 participants, we found no difference in 0- to 30-day mortality between low and high tidal volume groups (risk ratio (RR) 0.79, 95% confidence interval (CI) 0.40 to 1.54; I(2) statistic 0%; low quality evidence). Based on four studies including 601 participants undergoing abdominal or spinal surgery, we found a lower incidence of postoperative pneumonia in the lower tidal volume group (RR 0.44, 95% CI 0.20 to 0.99; I(2) statistic 19%; moderate quality evidence; NNTB 19, 95% CI 14 to 169). Based on two studies including 428 participants, low tidal volumes decreased the need for non-invasive postoperative ventilatory support (RR 0.31, 95% CI 0.15 to 0.64; moderate quality evidence; NNTB 11, 95% CI 9 to 19). Based on eight studies including 814 participants, low tidal volumes during surgery decreased the need for postoperative invasive ventilatory support (RR 0.33, 95% CI 0.14 to 0.80; I(2) statistic 0%; NNTB 36, 95% CI 27 to 202; moderate quality evidence). Based on three studies including 650 participants, we found no difference in the intensive care unit length of stay (standardized mean difference (SMD) -0.01, 95% CI -0.22 to 0.20; I(2) statistic = 42%; moderate quality evidence). Based on eight studies including 846 participants, we did not find a difference in hospital length of stay (SMD -0.16, 95% CI -0.40 to 0.07; I(2) statistic 52%; moderate quality evidence). A meta-regression showed that the effect size increased proportionally to the peak pressure measured at the end of surgery in the high volume group. We did not find a difference in the risk of pneumothorax (RR 2.01, 95% CI 0.51 to 7.95; I(2) statistic 0%; low quality evidence).
  
  
  CONCLUSIONS
  Low tidal volumes (defined as < 10 mL/kg) should be used preferentially during surgery. They decrease the need for postoperative ventilatory support (invasive and non-invasive). Further research is required to determine the maximum peak pressure of ventilation that should be allowed during surgery.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Joanne
authors.initials: J
authors.lastname: Guay
authors.forename: Edward A
authors.initials: EA
authors.lastname: Ochroch
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology* / Q000517:prevention & control; D000328:Adult; D000368:Aged; D001469:Barotrauma / Q000175:diagnosis / Q000209:etiology; D001835:Body Weight; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007327:Insufflation / Q000009:adverse effects / Q000379:methods; D007362:Intensive Care Units / Q000706:statistics & numerical data; D007430:Intraoperative Care / Q000379:methods; D007902:Length of Stay / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D063087:Noninvasive Ventilation / Q000706:statistics & numerical data; D011014:Pneumonia / Q000453:epidemiology; D011175:Positive-Pressure Respiration / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D011182:Postoperative Care / Q000706:statistics & numerical data; D001261:Pulmonary Atelectasis / Q000209:etiology / Q000628:therapy; D016032:Randomized Controlled Trials as Topic; D013990:Tidal Volume