title: Melatonin Has An Ergogenic Effect But Does Not Prevent Inflammation and Damage In Exhaustive Exercise.
abstract: It is well documented that exhaustive physical exercise leads to inflammation and skeletal muscle tissue damage. With this in mind, melatonin has been acutely administered before physical exercise; nevertheless, the use of melatonin as an ergogenic agent to prevent tissue inflammation and damage remains uncertain. We evaluated the effects of melatonin on swimming performance, muscle inflammation and damage and several physiological parameters after exhaustive exercise at anaerobic threshold intensity (iLAn) performed during light or dark circadian periods. The iLAn was individually determined and two days later, the animals performed an exhaustive exercise bout at iLAn 30 minutes after melatonin administration. The exercise promoted muscle inflammation and damage, mainly during the dark period, and the exogenous melatonin promoted a high ergogenic effect. The expressive ergogenic effect of melatonin leads to longer periods of muscle contraction, which superimposes a possible melatonin protective effect on the tissue damage and inflammation.
authors.affiliation: Laboratory of Applied Sport Physiology, School of Applied Sciences, Department of Sport Sciences, University of Campinas, Pedro Zaccaria Street, 1.300, Jardim Santa Luíza-Postal Code 13484-350-Limeira-São Paulo.
authors.forename: Wladimir Rafael
authors.initials: WR
authors.lastname: Beck
authors.affiliation: Laboratory of Molecular Biology of Exercise, School of Applied Sciences, Department of Sport Sciences, University of Campinas, Pedro Zaccaria Street, 1.300, Jardim Santa Luíza-Postal Code 13484-350-Limeira-São Paulo.
authors.forename: José Diego
authors.initials: JD
authors.lastname: Botezelli
authors.affiliation: Laboratory of Molecular Biology of Exercise, School of Applied Sciences, Department of Sport Sciences, University of Campinas, Pedro Zaccaria Street, 1.300, Jardim Santa Luíza-Postal Code 13484-350-Limeira-São Paulo.
authors.forename: José Rodrigo
authors.initials: JR
authors.lastname: Pauli
authors.affiliation: Laboratory of Molecular Biology of Exercise, School of Applied Sciences, Department of Sport Sciences, University of Campinas, Pedro Zaccaria Street, 1.300, Jardim Santa Luíza-Postal Code 13484-350-Limeira-São Paulo.
authors.forename: Eduardo Rochete
authors.initials: ER
authors.lastname: Ropelle
authors.affiliation: Laboratory of Applied Sport Physiology, School of Applied Sciences, Department of Sport Sciences, University of Campinas, Pedro Zaccaria Street, 1.300, Jardim Santa Luíza-Postal Code 13484-350-Limeira-São Paulo.
authors.forename: Claudio Alexandre
authors.initials: CA
authors.lastname: Gobatto
mesh_terms: D000818:Animals; D015415:Biomarkers; D004195:Disease Models, Animal; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism*; D008550:Melatonin / Q000378:metabolism* / Q000494:pharmacology; D051379:Mice; D018482:Muscle, Skeletal / Q000187:drug effects / Q000293:injuries* / Q000378:metabolism*; D058573:Performance-Enhancing Substances / Q000378:metabolism* / Q000494:pharmacology; D010805:Physical Conditioning, Animal; D051381:Rats; D017695:Soft Tissue Injuries / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D058573:Performance-Enhancing Substances; D008550:Melatonin