title: Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits.
abstract: In the development of addiction, drug seeking becomes habitual and controlled by drug-associated cues, and the neural locus of control over behaviour shifts from the ventral to the dorsolateral striatum. The neural mechanisms underlying this functional transition from recreational drug use to drug-seeking habits are unknown. Here we combined functional disconnections and electrophysiological recordings of the amygdalo-striatal networks in rats trained to seek cocaine to demonstrate that functional shifts within the striatum are driven by transitions from the basolateral (BLA) to the central (CeN) amygdala. Thus, while the recruitment of dorsolateral striatum dopamine-dependent control over cocaine seeking is triggered by the BLA, its long-term maintenance depends instead on the CeN. These data demonstrate that limbic cortical areas both tune the function of cognitive territories of the striatum and thereby underpin maladaptive cocaine-seeking habits.
authors.affiliation: Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK.|Behavioural and Clinical Neuroscience Institute of the University of Cambridge, Cambridge CB2 1QB, UK.
authors.forename: Jennifer E
authors.identifier: http://orcid.org/0000-0002-8992-7317
authors.initials: JE
authors.lastname: Murray
authors.affiliation: Behavioural and Clinical Neuroscience Institute of the University of Cambridge, Cambridge CB2 1QB, UK.|Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.
authors.forename: Aude
authors.initials: A
authors.lastname: Belin-Rauscent
authors.affiliation: Groupe de recherche en psychiatrie, Paris GDR3557, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Simon
authors.affiliation: Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK.|Behavioural and Clinical Neuroscience Institute of the University of Cambridge, Cambridge CB2 1QB, UK.
authors.forename: Chiara
authors.initials: C
authors.lastname: Giuliano
authors.affiliation: Laboratoire de Neurosciences Expérimentales et Clinique, INSERM, U1084, Poitiers F-86022, France.|Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, Poitiers F-86022, France.
authors.forename: Marianne
authors.initials: M
authors.lastname: Benoit-Marand
authors.affiliation: Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK.|Behavioural and Clinical Neuroscience Institute of the University of Cambridge, Cambridge CB2 1QB, UK.
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Everitt
authors.affiliation: Behavioural and Clinical Neuroscience Institute of the University of Cambridge, Cambridge CB2 1QB, UK.|Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.
authors.forename: David
authors.identifier: http://orcid.org/0000-0002-7383-372X
authors.initials: D
authors.lastname: Belin
mesh_terms: D000818:Animals; D066272:Basolateral Nuclear Complex / Q000187:drug effects* / Q000502:physiology; D001522:Behavior, Animal; D066274:Central Amygdaloid Nucleus / Q000187:drug effects* / Q000502:physiology; D003042:Cocaine / Q000008:administration & dosage*; D058999:Drug-Seeking Behavior / Q000187:drug effects / Q000502:physiology*; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D007555:Isoxazoles / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017470:Receptors, Glutamate; D012646:Self Administration; D013777:Tetrazoles / Q000494:pharmacology
chemical_list: D018691:Excitatory Amino Acid Antagonists; D007555:Isoxazoles; D017470:Receptors, Glutamate; D013777:Tetrazoles; D016202:N-Methylaspartate; D003042:Cocaine; C418233:2-amino-3-(3-hydrox-5(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl)propionic acid