title: Cerasomes: Soft Interface for Redox Enzyme Electrochemical Signal Transmission.
abstract: Anionic cerasomes, which consist of a liposomal lipid bilayer and a ceramic surface, were used as a soft interface for the construction of an integrated modified electrode to achieve the transmission of chemical information from a redox enzyme through electrical signals. The morphological properties of the cerasomes were systematically compared with those of two structural analogues, namely, liposomes and silica nanoparticles. The results indicated that the cerasomes combined the advantages of liposomes and silica nanoparticles. The lipid bilayer gave excellent biocompatibility, as in the case of liposomes, and high structural stability, similar to that of silica nanoparticles, was derived from the silicate framework on the cerasome surface. The performance at the electrochemical interface created by means of a combination of cerasomes and horseradish peroxidase on a glassy carbon electrode was much better than those achieved with liposomes or silica nanoparticles instead of cerasomes. The potential use of cerasomes in the construction of supramolecular devices for mediator-free biosensing was evaluated.
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.|Beijing Academy of Printing & Packaging Industrial Technology, Beijing Institute of Graphic Communication, Beijing, 102600, PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.
authors.forename: Keishiro
authors.initials: K
authors.lastname: Tahara
authors.affiliation: College of Chemistry, Liaoning University, Shenyang, 110036, P.R. China. zhangq@lnu.edu.cn.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Liaoning University, Shenyang, 110036, P.R. China. songlab@lnu.edu.cn.|Liaoning Key Laboratory for Green Synthesis, and Preparative Chemistry of Advanced Materials, Liaoning University, Shenyang, 110036, P.R. China. songlab@lnu.edu.cn.
authors.forename: Xi-Ming
authors.initials: XM
authors.lastname: Song
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan. jkikuchi@ms.naist.jp.
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kikuchi
mesh_terms: D004355:Drug Stability; D004563:Electrochemistry; D008081:Liposomes / Q000737:chemistry*; D053758:Nanoparticles; D010084:Oxidation-Reduction; D015398:Signal Transduction; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D008081:Liposomes; D012822:Silicon Dioxide
keywords: cerasomes; electrochemistry; enzymes; organic-inorganic hybrid composites; redox chemistry