title: Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma.
abstract: A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of this study was to identify specific miRNAs that are deregulated in tumor vs. normal kidney tissues and that could impact on the biology of ccRCC. To this end we selected four miRNAs (miR-21-5p, miR-210-3p, miR-185-5p and miR-221-3p) and their expression has been evaluated in a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) tissues from 20 ccRCC patients who underwent surgical nephrectomy resection. miR-21-5p and miR-210-3p resulted the most significantly up-regulated miRNAs in this patient cohort, highlighting these onco-miRNAs as possible relevant players involved in ccRCC tumorigenesis. Thus, this study reports the identification of specific oncogenic miRNAs that are altered in ccRCC tissues and suggests that they might be useful biomarkers in ccRCC management.
authors.affiliation: Pathology Unit, ICOT, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, Italy. vincenzo.petrozza@uniroma1.it.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Petrozza
authors.affiliation: Urology Unit, ICOT, Department of Medico Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, Italy. antonio.carbone@uniroma1.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Carbone
authors.affiliation: Department of Anatomical, Histological, Forensic &amp; Orthopaedic Sciences, Section of Histology &amp; Medical Embryology, Sapienza University of Rome, Rome 00161, Italy. teresa.bellissimo@uniroma1.it.
authors.forename: Teresa
authors.initials: T
authors.lastname: Bellissimo
authors.affiliation: Pathology Unit, ICOT, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, Italy. natale.porta@alice.it.
authors.forename: Natale
authors.initials: N
authors.lastname: Porta
authors.affiliation: Urology Unit, ICOT, Department of Medico Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, Italy. giovanni.palleschi@uniroma1.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Palleschi
authors.affiliation: Urology Unit, ICOT, Department of Medico Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, Italy. antonioluigi.pastore@uniroma1.it.
authors.forename: Antonio Luigi
authors.initials: AL
authors.lastname: Pastore
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, Italy. angelina.dicarlo@uniroma1.it.
authors.forename: Angelina
authors.initials: A
authors.lastname: Di Carlo
authors.affiliation: Pathology Unit, ICOT, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, Italy. carlo.dellarocca@uniroma1.it.
authors.forename: Carlo
authors.initials: C
authors.lastname: Della Rocca
authors.affiliation: Department of Anatomical, Histological, Forensic &amp; Orthopaedic Sciences, Section of Histology &amp; Medical Embryology, Sapienza University of Rome, Rome 00161, Italy. francesco.fazi@uniroma1.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Fazi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D016022:Case-Control Studies; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: clear cell renal cell carcinoma; miR-21-5p and miR-210-3p; microRNAs