title: Difference in left renal vein pressure: an indicator for free of reconstruction after ligation in retroperitoneal tumor patients.
abstract: We hypothesized that the left renal vein pressure difference (ΔP) before and after the ligation can serve as an objective indicator for free of reconstruction after resection of a retroperitoneal tumor with renal segment of inferior vena cava and right kidney. After established a model of left renal vein compression, 45 miniature pigs were operated on experimental procedures including renal segment of inferior vena cava resection, right nephrectomy, and left renal vein ligation. The ΔPs of left renal vein before and after the ligation were measured. Safe ΔP variation without causing acute kidney injury was calculated using regression analysis. In human the safety range of ΔP before and after ligation of the left renal vein was calculated by diuretic response test. The safety range of ΔP in animals or human was 0-11.9 or 0-17.5 cm H2O, respectively. The renal function changed dramatically (p < 0.01), characterized by a significant increase in the rate of acute kidney injury when the ΔP was beyond the upper limit of the safety range. In conclusion, ΔP can predict free of reconstruction after resection of a retroperitoneal tumor with the renal segment of the inferior vena cava and the right kidney.
authors.affiliation: Department of Retroperitoneal Tumors Surgery Peking University International Hospital, Beijing, P.R. China.
authors.forename: Chengli
authors.initials: C
authors.lastname: Miao
authors.affiliation: Department of Surgical Oncology, Beijing Shijitan Hospital, Capital Medical University (The 9th affiliated hospital of Peking University), Beijing, P.R. China.
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Xiao
authors.affiliation: Department of Surgical Oncology, Beijing Shijitan Hospital, Capital Medical University (The 9th affiliated hospital of Peking University), Beijing, P.R. China.
authors.forename: Tengyan
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Surgical Oncology, Beijing Shijitan Hospital, Capital Medical University (The 9th affiliated hospital of Peking University), Beijing, P.R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Surgical Oncology, Beijing Shijitan Hospital, Capital Medical University (The 9th affiliated hospital of Peking University), Beijing, P.R. China.
authors.forename: Xing
authors.initials: X
authors.lastname: Liu
authors.affiliation: Ultrasound Department, Beijing Shijitan Hospital, Capital Medical University (The 9th affiliated hospital of Peking University), Beijing, P.R. China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Kong
authors.affiliation: Department of Retroperitoneal Tumors Surgery Peking University International Hospital, Beijing, P.R. China.
authors.forename: Chenghua
authors.initials: C
authors.lastname: Luo
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000503:physiopathology; D000818:Animals; D005260:Female; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology / Q000601:surgery*; D007677:Kidney Function Tests; D008026:Ligation / Q000379:methods; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000379:methods; D011312:Pressure; D012044:Regression Analysis; D012082:Renal Veins / Q000503:physiopathology / Q000601:surgery*; D012186:Retroperitoneal Neoplasms / Q000098:blood supply / Q000503:physiopathology / Q000601:surgery*; D013552:Swine; D013556:Swine, Miniature; D014556:Urine; D014682:Vena Cava, Inferior / Q000503:physiopathology / Q000601:surgery*