title: The Increase in Animal Mortality Risk following Exposure to Sparsely Ionizing Radiation Is Not Linear Quadratic with Dose.
abstract: The US government regulates allowable radiation exposures relying, in large part, on the seventh report from the committee to estimate the Biological Effect of Ionizing Radiation (BEIR VII), which estimated that most contemporary exposures- protracted or low-dose, carry 1.5 fold less risk of carcinogenesis and mortality per Gy than acute exposures of atomic bomb survivors. This correction is known as the dose and dose rate effectiveness factor for the life span study of atomic bomb survivors (DDREFLSS). It was calculated by applying a linear-quadratic dose response model to data from Japanese atomic bomb survivors and a limited number of animal studies.
  
  
  
  We argue that the linear-quadratic model does not provide appropriate support to estimate the risk of contemporary exposures. In this work, we re-estimated DDREFLSS using 15 animal studies that were not included in BEIR VII's original analysis. Acute exposure data led to a DDREFLSS estimate from 0.9 to 3.0. By contrast, data that included both acute and protracted exposures led to a DDREFLSS estimate from 4.8 to infinity. These two estimates are significantly different, violating the assumptions of the linear-quadratic model, which predicts that DDREFLSS values calculated in either way should be the same.
  
  
  
  Therefore, we propose that future estimates of the risk of protracted exposures should be based on direct comparisons of data from acute and protracted exposures, rather than from extrapolations from a linear-quadratic model. The risk of low dose exposures may be extrapolated from these protracted estimates, though we encourage ongoing debate as to whether this is the most valid approach. We also encourage efforts to enlarge the datasets used to estimate the risk of protracted exposures by including both human and animal data, carcinogenesis outcomes, a wider range of exposures, and by making more radiobiology data publicly accessible. We believe that these steps will contribute to better estimates of the risks of contemporary radiation exposures.
authors.affiliation: Department of Radiation Oncology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America.
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Haley
authors.affiliation: Department of Radiation Oncology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Paunesku
authors.affiliation: Departments of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois, United States of America.
authors.forename: David J
authors.initials: DJ
authors.lastname: Grdina
authors.affiliation: Departments of Radiation Oncology, Radiology, and Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America.
authors.forename: Gayle E
authors.initials: GE
authors.lastname: Woloschak
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D009381:Neoplasms, Radiation-Induced; D011839:Radiation, Ionizing; D011853:Radiobiology; D018570:Risk Assessment; D012307:Risk Factors