title: Primary hepatic solitary fibrous tumor with histologically benign and malignant areas.
abstract: Extrapleural solitary fibrous tumor (SFT) is an uncommon mesenchymal neoplasm, presenting most commonly in the intrathoracic sites but which has been reported at numerous extrathoracic locations. The majority of intra-thoracic SFTs are benign, but 10%-15% behave aggressively. We report a case of primary hepatic SFT with histologically benign and malignant areas. A 65-year-old man underwent an abdominal CT scan following a cerebrovascular accident, which demonstrated a sharply demarcated large liver mass with a heterogenous enhancing area and occupying most of the left lobe of the liver. Histological examination following a hemihepatectomy showed an SFT with morphological patterns ranging from benign to malignant areas, including pleomorphism, increased cellularity, herringbone pattern, necrosis and a raised mitotic count. On review of the literature, only an occasional case report with malignant areas in a hepatic SFT was identified. This case highlights that SFT should be included in the differential diagnosis of a hepatic spindle cell lesion, and that on rare occasions, malignant areas can occur in this already uncommon neoplasm.
authors.affiliation: Departments of Histopathology, Royal Surrey County Hospital, Guildford, UK. izhar.bagwan@nhs.net.
authors.forename: Anna
authors.initials: A
authors.lastname: Silvanto
authors.forename: Nariman D
authors.initials: ND
authors.lastname: Karanjia
authors.forename: Izhar N
authors.initials: IN
authors.lastname: Bagwan
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D033162:Incidental Findings; D008113:Liver Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008297:Male; D008938:Mitosis; D009336:Necrosis; D018193:Neoplasms, Complex and Mixed / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D054364:Solitary Fibrous Tumors / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor