title: The global burden of major infectious complications following prostate biopsy.
abstract: We present a systematic review providing estimates of the overall and regional burden of infectious complications following prostate biopsy. A directly standardized prevalence estimate was used because it reflects the burden of disease more explicitly. Complications included sepsis, hospitalization, bacteraemia, bacteriuria, and acute urinary retention after biopsy. There were 165 articles, comprising 162 577 patients, included in the final analysis. Our findings demonstrate that transrectal biopsy was associated with a higher burden of hospitalization (1·1% vs. 0·9%) and sepsis (0·8% vs. 0·1%) compared to transperineal biopsy, while acute urinary retention was more prevalent after transperineal than transrectal biopsy (4·2% vs. 0·9%). The differences were statistically non-significant because of large heterogeneity across countries. We also demonstrate and discuss regional variations in complication rates, with Asian studies reporting higher rates of sepsis and hospitalization.
authors.affiliation: Centre for Clinical Research,The University of Queensland,Brisbane,Australia.
authors.forename: H Y
authors.identifier: 0000-0002-1224-0613
authors.initials: HY
authors.lastname: Bennett
authors.affiliation: Centre for Clinical Research,The University of Queensland,Brisbane,Australia.
authors.forename: M J
authors.initials: MJ
authors.lastname: Roberts
authors.affiliation: Research School of Population Health,The Australian National University,Canberra,Australia.
authors.forename: S A R
authors.initials: SA
authors.lastname: Doi
authors.affiliation: Centre for Clinical Research,The University of Queensland,Brisbane,Australia.
authors.forename: R A
authors.initials: RA
authors.lastname: Gardiner
mesh_terms: D001706:Biopsy / Q000009:adverse effects*; D003141:Communicable Diseases / Q000453:epidemiology*; D017281:Cost of Illness; D014943:Global Health; D006801:Humans; D008297:Male; D015995:Prevalence; D011469:Prostatic Diseases / Q000175:diagnosis*; D016055:Urinary Retention / Q000453:epidemiology
keywords: Infection; post-operative complications; prostate biopsy; prostatic neoplasms; transperineal; transrectal