title: [Fluorescence imaging in laryngology: Physical principles, clinical applications and study results].
abstract: BACKGROUND
  Early detection and adequate preoperative assessment of neoplastic lesions of the larynx allow for voice-preserving therapy concepts.
  
  
  OBJECTIVE
  The physical principles, clinical applications and most important study results of fluorescence imaging are presented.
  
  
  METHODS
  The entire literature on autofluorescence endoscopy of the larynx was analysed and compared to induced fluorescence endoscopy.
  
  
  RESULTS
  In detecting malignant and premalignant lesions of the larynx, autofluorescence endoscopy shows a significantly higher sensitivity, specificity and accuracy than white light endoscopy alone. Induced fluorescence endoscopy achieved an even higher sensitivity, albeit at the expense of specificity.
  
  
  CONCLUSIONS
  Autofluorescence endoscopy represents a simple screening procedure for early detection of laryngeal cancer and its precursor lesions, whereas induced fluorescence endoscopy is more suited for the identification of recurrent disease.
authors.affiliation: Klinik für Hals-, Nasen- und Ohrenheilkunde, Hals- und Gesichtschirurgie, Kantonsspital Baselland, Liestal, Schweiz. marcel.kraft@unibas.ch.|, Hübelmattweg 1, 4144, Arlesheim, Schweiz. marcel.kraft@unibas.ch.
authors.forename: M
authors.initials: M
authors.lastname: Kraft
authors.affiliation: Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Magdeburg A. ö. R., Magdeburg, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Arens
authors.affiliation: Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde, Klinikum Großhadern, Ludwig-Maximilians-Universität, München, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Betz
authors.affiliation: Klinik für Hals-, Nasen- und Ohrenheilkunde, Hals- und Gesichtschirurgie, Kantonsspital Baselland, Liestal, Schweiz.
authors.forename: K
authors.initials: K
authors.lastname: Fostiropoulos
mesh_terms: D055088:Early Detection of Cancer / Q000379:methods*; D019317:Evidence-Based Medicine; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007822:Laryngeal Neoplasms / Q000473:pathology*; D007828:Laryngoscopy / Q000379:methods*; D008856:Microscopy, Fluorescence / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: Autofluorescence imaging; Diagnostic imaging; Larynx; Otorhinolaryngologic neoplasms; Precancerous conditions