title: Eosinophils in Colorectal Neoplasms Associated with Expression of CCL11 and CCL24.
abstract: BACKGROUND
  A decrease in the number of tissue eosinophils is known to reflect the malignancy potential of neoplastic lesions and even prognosis. Increased levels of the chemokines CCL11 and CCL24 in serum and tissue are also known to have diagnostic value as serum tumor markers or prognostic factors. The aim of this study was to evaluate the correlation between the degree of tissue eosinophilia and the expression of these chemokines in the glandular and stromal cells of colorectal neoplastic lesions ranging from benign to malignant tumors.
  
  
  METHODS
  We counted the number of infiltrating eosinophils in neoplastic lesion tissue and we evaluated the expression of CCL11 and CCL24 in glandular cells and stromal cells by immunohistochemical staining.
  
  
  RESULTS
  The results showed that the number of eosinophils decreased significantly and the expression of CCL11 and CCL24 in glandular cells decreased with tumor progression, whereas the stromal expression of CCL11 and CCL24 appeared to increase.
  
  
  CONCLUSIONS
  The discrepancy in CCL11 and CCL24 expression between glandular cells and stromal cells might shed light on how colorectal cancer evades the immune system, which would enable further development of immunotherapies that target these chemokines. Further research on eosinophil biology and the expression pattern of chemokines in tumor cells is needed.
authors.affiliation: Department of Pathology, Kyung Hee University Medical Center, Graduate School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Hyuck
authors.initials: H
authors.lastname: Cho
authors.affiliation: Department of Pathology, Kyung Hee University Hospital of Gangdong, Seoul, Korea.
authors.forename: Sung-Jig
authors.initials: SJ
authors.lastname: Lim
authors.affiliation: Department of Pathology, Kyung Hee University Hospital of Gangdong, Seoul, Korea.
authors.forename: Kyu Yeoun
authors.initials: KY
authors.lastname: Won
authors.affiliation: Department of Pathogy, Kyung Hee University Hospital of Gangdong, Graduate School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Go Eun
authors.initials: GE
authors.lastname: Bae
authors.affiliation: Department of Pathology, Kyung Hee University Hospital of Gangdong, Seoul, Korea.
authors.forename: Gou Young
authors.initials: GY
authors.lastname: Kim
authors.affiliation: Department of Pathology, Kyung Hee University Medical Center, Graduate School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Min
authors.affiliation: Department of Pathology, Kyung Hee University Medical Center, Seoul, Korea.
authors.forename: Byeong-Joo
authors.initials: BJ
authors.lastname: Noh
keywords: CCL11; CCL24; Colorectal neoplasms; Eosinophils