title: Innovation in medicine: Ignaz the reviled and Egas the regaled.
abstract: In our current climate of rapid technological progress, it seems counterintuitive to think that modern science can learn anything of ethical value from the dark recesses of the nineteenth century or earlier. However, this happens to be quite true, with plenty of knowledge and wisdom to be gleaned by studying our scientific predecessors. Presently, our journals are flooded with original concepts and potential breakthroughs, a continuous stream of ideas pushing the frontiers of knowledge ever forward. Some ideas flourish while others flounder; but what sets the two apart? The distinguishing feature between success and failure within this context is the ability to discern the appropriate time to accept an innovation with open arms, versus when to take a more cautious approach. And the primary arbiters for whether an idea will catch on or not are the professional audience. I illustrate this concept by comparing the initial reception of two innovative ideas from Medicine's past: sterile technique, and prefrontal lobotomy. Sterile technique was first introduced by Dr. Ignaz Semmelweis and was initially ridiculed and rejected, with Semmelweis eventually dying in exile. Conversely, lobotomy was accepted and lauded and its inventor, Dr. Egas Moniz, won the Nobel Prize for his "discovery". This begs the question: why was a technique with the potential to save millions of lives initially rejected, whereas paradoxically, one that compromised and sometimes destroyed lives, accepted? Here I explore and analyze the potential reasons why, suggest how we can learn from these mistakes of the past and apply new insight to some current ethical dilemmas.
authors.affiliation: Epigenetics Laboratory, Department of Anatomy, Howard University, 520 W St. NW, 431 Mudd Building, Washington, DC, 20059, USA. antonei.csoka@howard.edu.
authors.forename: Antonei Benjamin
authors.initials: AB
authors.lastname: Csoka
mesh_terms: D004059:Diffusion of Innovation; D004992:Ethics, Medical / Q000266:history; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D006814:Hungary; D062069:Inventions / Q000941:ethics / Q000266:history*; D011174:Portugal; D011612:Psychosurgery / Q000941:ethics / Q000266:history; D013242:Sterilization / Q000941:ethics / Q000266:history
keywords: Clinical ethics; Drugs and drug industry; History of health ethics; Iatrogenesis; Lobotomy; Maternal mortality; Puerperal fever