title: Fentanyl-Induced Neurotoxicity in Children.
abstract: Fentanyl-induced neurotoxicity is an uncommon adverse effect of fentanyl and is seldom seen in pediatric palliative care practice. It presents as myriad of nonspecific symptoms such as severe pain, allodynia, insomnia, agitation, hallucinations, behavioral changes, and headache. In children, it is often missed and misdiagnosed. This is a case report of an 11-year-old girl; a case of locally advanced neuroblastoma, progressed on disease-modifying treatment, and referred to pediatric palliative care for best supportive care. She developed features of fentanyl-induced neurotoxicity during upward titration of transdermal fentanyl that was promptly identified and managed in a pediatric palliative care setting.
authors.forename: Shrenik
authors.initials: S
authors.lastname: Ostwal
authors.forename: Naveen
authors.initials: N
authors.lastname: Salins
authors.forename: Jayita
authors.initials: J
authors.lastname: Deodhar
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Muckaden
mesh_terms: D017109:Akathisia, Drug-Induced; D000701:Analgesics, Opioid / Q000009:adverse effects; D002648:Child; D005260:Female; D005283:Fentanyl / Q000009:adverse effects*; D006212:Hallucinations / Q000139:chemically induced*; D006261:Headache / Q000139:chemically induced*; D006801:Humans; D006930:Hyperalgesia / Q000139:chemically induced*; D010146:Pain / Q000139:chemically induced*; D010166:Palliative Care
chemical_list: D000701:Analgesics, Opioid; D005283:Fentanyl
keywords: children; fentanyl; neurotoxicity; pain; pediatrics