title: Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy.
abstract: An efficient strategy for the one-pot synthesis of polysubstituted pyridines via a cascade reaction from aldehydes, phosphorus ylides, and propargyl azide is reported. The reaction sequence involves a Wittig reaction, a Staudinger reaction, an aza-Wittig reaction, a 6π-3-azatriene electrocyclization, and a 1,3-H shift. This protocol provides quick access to the polysubstituted pyridines from readily available substrates in good to excellent yields.
authors.affiliation: The State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engeneering, Lanzhou University , Lanzhou 730000, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Wei
authors.affiliation: The State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engeneering, Lanzhou University , Lanzhou 730000, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.affiliation: The State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engeneering, Lanzhou University , Lanzhou 730000, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Xiao
authors.affiliation: The State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engeneering, Lanzhou University , Lanzhou 730000, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Cheng
authors.affiliation: Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University , Shenzhen 518055, China.
authors.forename: Huifei
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Brandeis University , Waltham, Massachusetts 02454-9110, United States.
authors.forename: Lin
authors.initials: L
authors.lastname: Hu
authors.affiliation: The State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engeneering, Lanzhou University , Lanzhou 730000, China.|Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University , Shenzhen 518055, China.|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300071, China.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zhai