title: Stress Flips a Chromatin Switch to Wake Up Latent Virus.
abstract: Stress-induced reactivation of latent herpesviruses requires disabling of repression, but the mechanism for converting silenced chromatin into an active state is unknown. In this issue of Cell Host & Microbe, Cliffe et al. (2015) suggest a methyl/phospho switch on histone H3 overcomes repression to facilitate reactivation of latent herpes simplex virus type 1 (HSV-1).
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors.forename: Daphne C
authors.initials: DC
authors.lastname: Avgousti
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address: weitzmanm@email.chop.edu.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Weitzman
mesh_terms: D002843:Chromatin; D006561:Herpes Simplex / Q000821:virology; D018259:Herpesvirus 1, Human / Q000235:genetics; D006657:Histones; D006801:Humans; D014775:Virus Activation; D017735:Virus Latency
chemical_list: D002843:Chromatin; D006657:Histones