title: [Value of fractional flow reserve measurement in endovascular therapy for patients with Stanford B type aortic dissection complicated with renal blood flow injury].
abstract: OBJECTIVE
  To analyze the value of fractional flow reserve (FFR) measurement on endovascular therapy for patients with renal artery stenosis.
  
  
  METHODS
  Clinical data of 12 patients with Stanford B type aortic dissection complicated with renal blood flow injury in Anzhen hospital hospitalized from May 2013 to February 2014 were retrospectively analyzed. Renal artery angiography was performed and fractional flow reserve (FFR) was measured before Thoracic endovascular aortic repair. After operation, renal artery FFR was measured again, and renal artery stenting was performed in patients with FFR ≤ 0.90 or average pressure difference between proximal and distal of renal artery > 20 mmHg (1 mmHg = 0.133 kPa) and not applied for patients with FFR > 0.90.The patients were then subsequently followed up clinically. Kidney function were measured after 1 month, and contrast-enhanced ultrasonography data were obtained at 1 and 3 months later, respectively.
  
  
  RESULTS
  The FFR of 1 patient was 0.90, while the FFR of other patients were less than 0.90 before thoracic endovascular aortic repair. After the procedure,the angiography showed that the blood flow of renal artery in 8 patients were fluency, and the FFR index was over 0.90. There were 4 patients with FFR less than 0.90. After renal artery stenting, the FFR of these 4 patients were all above 0.90. Compared with pre-procedure, blood urea nitrogen ((8.84 ± 3.99) mmol/L vs. (5.18 ± 1.69) mmol/L, P = 0.011) and uric acid ((359.3 ± 77.3) µmol/L vs. (276.9 ± 108.3) µmol/L, P = 0.008) decreased significantly after 1 month, and there was no significant difference in serum creatinine (P = 0.760). Contrast-enhanced ultrasonography results showed that blood flow of renal artery were fluency after 1 month and 3 months.
  
  
  CONCLUSIONS
  In patients with aortic dissection complicating renal blood flow injury, the FFR measurement is meaningful in evaluating the blood flow status of target organs and guide the endovascular revascularization.
authors.affiliation: Department of Interventional Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Guo
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Guangrui
authors.initials: G
authors.lastname: Liu
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Huang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yong
authors.forename: Guoqin
authors.initials: G
authors.lastname: Wang
authors.affiliation: Email: huanglianjun2008@163.com.
authors.forename: Lianjun
authors.initials: L
authors.lastname: Huang
mesh_terms: D000784:Aortic Dissection; D001014:Aortic Aneurysm; D057510:Endovascular Procedures; D006439:Hemodynamics; D006801:Humans; D007668:Kidney / Q000293:injuries*; D012079:Renal Circulation; D012189:Retrospective Studies; D015607:Stents