title: The Use of Contact Lenses as Biosensors.
abstract: : The tear film is a complex multilayer film consisting of various proteins, enzymes, and lipids and can express a number of biomarkers in cases of disease. The development of a contact lens sensor presents a noninvasive alternative for the detection and management of various diseases. Recent work has resulted in the commercialization of a device to monitor intraocular pressure for up to 24 h, and there are extensive efforts underway to develop a contact lens sensor capable of continuous glucose tear film monitoring to manage diabetes. This clinical perspective will highlight the major developments within this field and list some of the major challenges that still need to be addressed.
authors.affiliation: *MSc †PhD, BSOptom, MSc, FAAO ‡PhD, FCOptom, FAAO Centre for Contact Lens Research, School of Optometry and Vision Science, Waterloo, Ontario, Canada (all authors).
authors.forename: Chau-Minh
authors.initials: CM
authors.lastname: Phan
authors.forename: Lakshman
authors.initials: L
authors.lastname: Subbaraman
authors.forename: Lyndon W
authors.initials: LW
authors.lastname: Jones
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D003261:Contact Lenses; D048909:Diabetes Complications / Q000175:diagnosis; D005901:Glaucoma / Q000175:diagnosis; D005947:Glucose / Q000032:analysis; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008991:Monitoring, Physiologic; D013666:Tears / Q000737:chemistry
chemical_list: D005947:Glucose