title: Seizures after intracerebral hemorrhage; risk factor, recurrence, efficacy of antiepileptic drug.
abstract: OBJECTIVE
  This study aimed to determine the risk factors for recurrent post stroke seizure (PSS) and the efficacy of anti-epileptic drugs (AED) in patients having intracerebral hemorrhage (ICH) with initial seizure.
  
  
  METHODS
  A total of 1920 consecutive patients with ICH from 2004 to 2012 were investigated retrospectively. The relationships among the baseline clinical and radiological data, administration of AED, and incidence of initial and recurrent PSS were evaluated using multiple logistic regression analysis.
  
  
  RESULTS
  Seizures occurred in 127 (6.6%) of the 1920 patients, displaying statistically significant relationships with cortical involvement of a cerebral lesion (P<0.001), non-hypertensive ICH (P<0.001), younger age (P<0.001), and severe neurological deficits (P<0.001). Early (4.3%) and late seizure (2.3%) had no significant relationship with the development of recurrent PSS. Larger volume of hematoma was the only independent factor associated with recurrence of PSS (OR 1.03; 95% CI 1.00-1.05; P=0.027). A Kaplan Meier survival analysis revealed that AED treatment had a poor association with recurrence of PSS (P=0.750).
  
  
  CONCLUSIONS
  Larger volume of hematoma was predictive of recurrence of PSS. AED therapy had poor association with preventing the recurrence of PSS.
authors.affiliation: Department of Neurology, Brain Attack Center Ota, Memorial Hospital, 3-6-28 Okinogami, Fukuyama, Hiroshima 720-0825, Japan. Electronic address: neshige@shouwa.or.jp.
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Neshige
authors.affiliation: Department of Neurology, Brain Attack Center Ota, Memorial Hospital, 3-6-28 Okinogami, Fukuyama, Hiroshima 720-0825, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Kuriyama
authors.affiliation: Department of Neurology, Brain Attack Center Ota, Memorial Hospital, 3-6-28 Okinogami, Fukuyama, Hiroshima 720-0825, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshimoto
authors.affiliation: Department of Neurology, Brain Attack Center Ota, Memorial Hospital, 3-6-28 Okinogami, Fukuyama, Hiroshima 720-0825, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takeshima
authors.affiliation: Department of Neurology, Brain Attack Center Ota, Memorial Hospital, 3-6-28 Okinogami, Fukuyama, Hiroshima 720-0825, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Himeno
authors.affiliation: Department of Neurology, Brain Attack Center Ota, Memorial Hospital, 3-6-28 Okinogami, Fukuyama, Hiroshima 720-0825, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takamatsu
authors.affiliation: Department of Neurosurgery, Brain Attack Center Ota, Memorial Hospital, 3-6-28 Okinogami, Fukuyama, Hiroshima 720-0825, Japan.
authors.forename: Michiyoshi
authors.initials: M
authors.lastname: Sato
authors.affiliation: Department of Neurosurgery, Brain Attack Center Ota, Memorial Hospital, 3-6-28 Okinogami, Fukuyama, Hiroshima 720-0825, Japan.
authors.forename: Shinzo
authors.initials: S
authors.lastname: Ota
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000627:therapeutic use*; D002543:Cerebral Hemorrhage / Q000150:complications*; D015331:Cohort Studies; D004827:Epilepsy / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors
chemical_list: D000927:Anticonvulsants
keywords: Early seizure; Hemorrhage; Intracerebral; Late seizure; Post stroke epilepsy; Recurrent seizure; Volume of hematoma