title: Aptamers Against Immunologic Targets: Diagnostic and Therapeutic Prospects.
abstract: The concept of in vitro selection of nucleic acid aptamers emerged 25 years ago, and since then tremendous progress has been achieved in the development of different aptamers and their applications for various bioanalytical and therapeutic purposes. Among other protein targets of aptamers, immune system proteins are of particular interest both as diagnostic markers and therapeutic targets. The present review summarizes up-to-date articles concerning the selection and design of DNA and RNA aptamers against immunologic targets such as antibodies, cytokines, and T-cell and B-cell receptors. We also discuss the prospects of employing aptamers as recognizing modules of diagnostic aptasensors, potential therapeutic candidates for the treatment of autoimmune diseases and cancer, and specific tools for functional studies of immune system proteins.
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine , Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia .
authors.forename: Mariya
authors.initials: M
authors.lastname: Vorobyeva
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine , Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia .
authors.forename: Valentina
authors.initials: V
authors.lastname: Timoshenko
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine , Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia .
authors.forename: Pavel
authors.initials: P
authors.lastname: Vorobjev
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine , Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia .
authors.forename: Alya
authors.initials: A
authors.lastname: Venyaminova
mesh_terms: D000906:Antibodies / Q000276:immunology; D052157:Aptamers, Nucleotide; D016207:Cytokines / Q000037:antagonists & inhibitors; D006801:Humans; D011947:Receptors, Antigen, B-Cell / Q000037:antagonists & inhibitors; D011948:Receptors, Antigen, T-Cell / Q000037:antagonists & inhibitors
chemical_list: D000906:Antibodies; D052157:Aptamers, Nucleotide; D016207:Cytokines; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell