title: [ANALYSIS OF THE ASSOCIATIONS BETWEEN ANGIOTENSIN-CONVERTING ENZYME GENE POLYMORPHISM AND ARTERIAL HYPOTENSION IN PREMATURE INFANTS WITH EARLY ONSET BACTERIAL INFECTIONS].
abstract: The rate of neonatal sepsis is not reduced varying inversely proportional to the gestational age at birth, and may reach 60% in the most immature infants. The high mortality rate of this disease and adverse neurological effects are associated with the development of cardiovascular changes and shock. The main leadership role in the regulation of blood pressure and blood volume in the body plays a renin-angiotensin system. Synthesis of angiotensin-converting enzyme is regulated by the ACE gene. The aim of the study was to identify and analyze the associations between the development of arterial hypotension in premature infants and insertion-deletion (I/D) polymorphism of the ACE gene. We conducted a prospective cohort study, which included 118 prematurely born children with early onset bacterial infections (n=57 with clinical manifestations in the form of hypotension, n=61 without hypotension). Both groups were genotyped to determine the insertion-deletion polymorphism ACE gene. We compared the clinical, laboratory and instrumental parameters in premature infants with hypotension and II, ID, DD genotype of the ACE gene. Also an analysis of the associations between different genotypes of ACE gene and the development of arterial hypotension in prematurely born children was conducted. The distribution of neonates in relation to the three polymorphic variants of ACE gene with respect to I/D polymorphism was identical among the study groups. The study found that children with a variety of I/D polymorphic variants of ACE gene had no significant differences in hemodynamic parameters. The rate of hemodynamic support use did not differ in both groups. The study of the associations between the ACE gene polymorphism and major ultrasound, Doppler indices that characterized both systemic and organ hemodynamics, revealed no significant differences in mean values of all the criteria that have been studied. It can be concluded no effect of I/D polymorphism of ACE gene on the occurrence of hemodynamic disorders in premature born children with early onset bacterial infections.
authors.affiliation: Higher Educational Institution of Ukraine "Ukrainian Medical Dental Academy", Poltava, Ukraine.
authors.forename: E
authors.initials: E
authors.lastname: Kovaleva
authors.affiliation: Higher Educational Institution of Ukraine "Ukrainian Medical Dental Academy", Poltava, Ukraine.
authors.forename: V
authors.initials: V
authors.lastname: Pokhylko
authors.affiliation: Higher Educational Institution of Ukraine "Ukrainian Medical Dental Academy", Poltava, Ukraine.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chernyavskaya
authors.affiliation: Higher Educational Institution of Ukraine "Ukrainian Medical Dental Academy", Poltava, Ukraine.
authors.forename: E
authors.initials: E
authors.lastname: Kalyuzka
authors.affiliation: Higher Educational Institution of Ukraine "Ukrainian Medical Dental Academy", Poltava, Ukraine.
authors.forename: V
authors.initials: V
authors.lastname: Poltoropavlov
mesh_terms: D001424:Bacterial Infections / Q000150:complications / Q000235:genetics* / Q000401:mortality / Q000503:physiopathology; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D015870:Gene Expression; D005838:Genotype; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007022:Hypotension / Q000150:complications / Q000235:genetics* / Q000401:mortality / Q000503:physiopathology; D054643:INDEL Mutation; D007223:Infant; D007226:Infant Mortality / Q000639:trends; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D000071074:Neonatal Sepsis / Q000150:complications / Q000235:genetics* / Q000401:mortality / Q000503:physiopathology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012084:Renin-Angiotensin System / Q000502:physiology; D016019:Survival Analysis
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A