title: Cancer immunotherapy targeting neoantigens.
abstract: Neoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunotherapy. Here we review the discoveries of neoantigens in the past two decades and the current advances in neoantigen identification. We also discuss the potential benefits and obstacles to the development of effective cancer immunotherapies targeting neoantigens.
authors.affiliation: Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10-CRC, Rm 3W-3864, 10 Center Dr, MSC 1201, Bethesda, MD 20892, United States. Electronic address: Yong-Chen.Lu@nih.gov.
authors.forename: Yong-Chen
authors.initials: YC
authors.lastname: Lu
authors.affiliation: Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10-CRC, Rm 3W-3864, 10 Center Dr, MSC 1201, Bethesda, MD 20892, United States. Electronic address: Paul_Robbins@nih.gov.
authors.forename: Paul F
authors.initials: PF
authors.lastname: Robbins
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics / Q000378:metabolism*; D001324:Autoantigens / Q000235:genetics; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009154:Mutation / Q000235:genetics; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D057285:Precision Medicine
chemical_list: D000951:Antigens, Neoplasm; D001324:Autoantigens
keywords: Cancer immunotherapy; Mutation; Neoantigen; Tumor immunology