title: Clinical and Epidemiological Characterization of the First Recognized Outbreak of Dengue Virus-Type 2 in Mozambique, 2014.
abstract: Since the first reported epidemic of dengue in Pemba, the capital of Cabo Delgado province, in 1984-1985, no further cases have been reported in Mozambique. In March 2014, the Provincial Health Directorate of Cabo Delgado reported a suspected dengue outbreak in Pemba, associated with a recent increase in the frequency of patients with nonmalarial febrile illness. An investigation conducted between March and June detected a total of 193 clinically suspected dengue patients in Pemba and Nampula, the capital of neighboring Nampula Province. Dengue virus-type 2 (DENV-2) was detected by reverse transcriptase polymerase chain reaction in sera from three patients, and 97 others were classified as probable cases based on the presence of DENV nonstructural protein 1 antigen or anti-DENV immunoglobulin M antibody. Entomological investigations demonstrated the presence of Aedes aegypti mosquitos in both Pemba and Nampula cities.
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique mariliamassangaie@yahoo.com.br.
authors.forename: Marilia
authors.initials: M
authors.lastname: Massangaie
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Pinto
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Fernando
authors.initials: F
authors.lastname: Padama
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Geraldo
authors.initials: G
authors.lastname: Chambe
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Mariana
authors.initials: M
authors.lastname: da Silva
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Inocêncio
authors.initials: I
authors.lastname: Mate
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Celia
authors.initials: C
authors.lastname: Chirindza
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Sadia
authors.initials: S
authors.lastname: Ali
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Sãozinha
authors.initials: S
authors.lastname: Agostinho
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Daniel
authors.initials: D
authors.lastname: Chilaule
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Weyer
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Chantel
authors.initials: C
authors.lastname: le Roux
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Abilio
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Baltazar
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Doyle
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Julie
authors.initials: J
authors.lastname: Cliff
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Janusz
authors.initials: J
authors.lastname: Paweska
authors.affiliation: National Directorate of Public Health, Ministry of Health, Maputo, Mozambique; National Institute of Health, Ministry of Health, Maputo, Mozambique; Cabo Delgado Provincial Health Directorate, Pemba, Mozambique; Nampula Provincial Health Directorate, Nampula, Mozambique; Centre for Emerging and Zoonotic Diseases, National Institute of Communicable Disease, Johannesburg, South Africa; Center for Global Health, Centers for Disease Control and Prevention, Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
authors.forename: Eduardo Samo
authors.initials: ES
authors.lastname: Gudo
mesh_terms: D000293:Adolescent; D000328:Adult; D003715:Dengue / Q000453:epidemiology* / Q000821:virology*; D003716:Dengue Virus / Q000145:classification*; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D008297:Male; D009073:Mozambique / Q000453:epidemiology; D055815:Young Adult