title: Transplantation of mesenchymal stem cells improves type 1 diabetes mellitus.
abstract: Bone-marrow-derived stem cells can regenerate pancreatic tissue in a model of type 1 diabetes mellitus. Mesenchymal stem cells (MSCs) form the main part of bone marrow. We show that the intrapancreatic transplantation of MSCs elevates serum insulin and C-peptide, while decreasing blood glucose. MSCs engrafted into the damaged rat pancreas become distributed into the blood vessels, acini, ducts, and islets. Renascent islets, islet-like clusters, and a small number of MSCs expressing insulin protein have been observed in the pancreas of diabetic rats. Intrapancreatic transplantation of MSCs triggers a series of molecular and cellular events, including differentiation towards the pancreas directly and the provision of a niche to start endogenous pancreatic regeneration, which ameliorates hypoinsulinemia and hyperglycemia caused by streptozotocin. These data establish the many roles of MSCs in the restoration of the function of an injured organ.
authors.affiliation: The Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune College of Medicine, Jilin University, Changchun, People's Republic of China. lilisha@jlu.edu.cn.
authors.forename: Lisha
authors.initials: L
authors.lastname: Li
authors.affiliation: The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Guangzhou, People's Republic of China.
authors.forename: Furong
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of General Surgery, Baoan Central Hospital of Shenzhen, Shenzhen, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.affiliation: The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Guangzhou, People's Republic of China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Yang
authors.affiliation: The Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune College of Medicine, Jilin University, Changchun, People's Republic of China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: The Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune College of Medicine, Jilin University, Changchun, People's Republic of China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Guo
authors.affiliation: The Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune College of Medicine, Jilin University, Changchun, People's Republic of China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology; D002096:C-Peptide / Q000097:blood*; D002454:Cell Differentiation; D002478:Cells, Cultured; D003921:Diabetes Mellitus, Experimental / Q000628:therapy*; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced / Q000628:therapy*; D005260:Female; D005951:Glucose Tolerance Test; D006943:Hyperglycemia / Q000139:chemically induced / Q000628:therapy*; D007328:Insulin / Q000097:blood*; D007515:Islets of Langerhans / Q000502:physiology; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D010179:Pancreas / Q000166:cytology / Q000601:surgery; D061251:Primary Cell Culture; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration / Q000502:physiology
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin
keywords: Intrapancreatic transplantation; Islet regeneration; Mesenchymal stem cells; Rat; Type 1 diabetes mellitus