title: [Efficacy of polyprenyl phosphates in the experimental genital herpes model].
abstract: An experimental model of the primary genital herpes (herpes simplex type 2, HSV-2) in the female guinea pigs was suggested to study the infectious process activity of polyprenyl phosphates (PPP) and PPP+acyclovir (AC) complex treatment. The morphofunctional features of the guinea pig ovaries were studied in the control and experimental groups (the latter were inoculated with PPP and/or AC as a primary infection treatment) at the stage of the recurrent genital herpes aggravation. It was shown that in the case of combined PPP +AC use significant changes in the disease symptoms were observed, as well as a decrease in the infectious process activity and duration, and positive remote effect on the ovarian morphophysiology.
authors.forename: A N
authors.initials: AN
authors.lastname: Narovlyansky
authors.forename: A M
authors.initials: AM
authors.lastname: Ivanova
authors.forename: N V
authors.initials: NV
authors.lastname: Shevlyagina
authors.forename: L V
authors.initials: LV
authors.lastname: Didenko
authors.forename: T G
authors.initials: TG
authors.lastname: Borovaya
authors.forename: A V
authors.initials: AV
authors.lastname: Izmest'eva
authors.forename: A V
authors.initials: AV
authors.lastname: Sanin
authors.forename: A V
authors.initials: AV
authors.lastname: Pronin
authors.forename: F I
authors.initials: FI
authors.lastname: Ershov
mesh_terms: D000212:Acyclovir / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000378:metabolism; D018258:Herpesvirus 2, Human / Q000378:metabolism*; D006801:Humans; D011106:Polyisoprenyl Phosphates / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D011106:Polyisoprenyl Phosphates; D000212:Acyclovir