title: Advances in genomics, transcriptomics and proteomics of toxin-producing cyanobacteria.
abstract: A common misconception persists that the genomes of toxic and non-toxic cyanobacterial strains are largely conserved with the exception of the presence or absence of the genes responsible for toxin production. Implementation of -omics era technologies has challenged this paradigm, with comparative analyses providing increased insight into the differences between strains of the same species. The implementation of genomic, transcriptomic and proteomic approaches has revealed distinct profiles between toxin-producing and non-toxic strains. Further, metagenomics and metaproteomics highlight the genomic potential and functional state of toxic bloom events over time. In this review, we highlight how these technologies have shaped our understanding of the complex relationship between these molecules, their producers and the environment at large within which they persist.
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Biological Sciences Building D26, Sydney, NSW, 2052, Australia.
authors.forename: Paul M
authors.identifier: http://orcid.org/0000-0002-8323-5416
authors.initials: PM
authors.lastname: D'Agostino
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Biological Sciences Building D26, Sydney, NSW, 2052, Australia.
authors.forename: Jason N
authors.initials: JN
authors.lastname: Woodhouse
authors.affiliation: Department of Microbiology, Institute for Biochemistry and Biology, University of Potsdam, Potsdam-Golm, 14476, Germany.
authors.forename: A Katharina
authors.initials: AK
authors.lastname: Makower
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Biological Sciences Building D26, Sydney, NSW, 2052, Australia.
authors.forename: Anna C Y
authors.initials: AC
authors.lastname: Yeung
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Biological Sciences Building D26, Sydney, NSW, 2052, Australia.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Ongley
authors.affiliation: School of Science and Health, University of Western Sydney, Sydney, NSW, 2571, Australia.
authors.forename: Melinda L
authors.initials: ML
authors.lastname: Micallef
authors.affiliation: School of Science and Health, University of Western Sydney, Sydney, NSW, 2571, Australia.
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Moffitt
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Biological Sciences Building D26, Sydney, NSW, 2052, Australia.
authors.forename: Brett A
authors.initials: BA
authors.lastname: Neilan
mesh_terms: D001427:Bacterial Toxins / Q000378:metabolism*; D000458:Cyanobacteria / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling / Q000379:methods* / Q000639:trends; D023281:Genomics / Q000379:methods* / Q000639:trends; D040901:Proteomics / Q000379:methods* / Q000639:trends
chemical_list: D001427:Bacterial Toxins