title: A new taraxastane-type triterpenoid glycoside from the roots of Clematis uncinata.
abstract: A new taraxastane-type triterpenoid glycoside, clematiunicinoside I (1), together with four known ones (2-5), was isolated from the roots of Clematis uncinata. The structure of the new compound was elucidated on the basis of spectroscopic analyses and acid hydrolysis. The cytotoxic activities of all the compounds against caski cervical cancer (Caski) cells were evaluated. This is the first report of the presence of taraxastane-type triterpenoid glycoside in the genus Clematis.
authors.affiliation: a Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , China.|b JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research , Jinan University , Guangzhou 510632 , China.
authors.forename: Shuo-Guo
authors.initials: SG
authors.lastname: Li
authors.affiliation: a Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , China.
authors.forename: Man-Mei
authors.initials: MM
authors.lastname: Li
authors.affiliation: a Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , China.|b JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research , Jinan University , Guangzhou 510632 , China.
authors.forename: Bing-Xin
authors.initials: BX
authors.lastname: Zhao
authors.affiliation: a Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , China.|b JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research , Jinan University , Guangzhou 510632 , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , China.|b JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research , Jinan University , Guangzhou 510632 , China.
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D039324:Clematis / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D006027:Glycosides; D014315:Triterpenes; C000607670:clematiunicinoside I
keywords: Clematis uncinata; Ranunculaceae; taraxastane-type triterpenoid glycoside