title: Expression of CPEB4 in invasive ductal breast carcinoma and its prognostic significance.
abstract: OBJECTIVE
  Cytoplasmic polyadenylation element binding proteins (CPEBs) are RNA-binding proteins that regulate translation by inducing cytoplasmic polyadenylation. CPEB4 has been reported in association with tumor growth, vascularization, and invasion in several cancers. To date, the expression of CPEB4 with clinical prognosis of breast cancer was never reported before. We aim to investigate the expression of CPEB4 and its prognostic significance in invasive ductal breast carcinoma.
  
  
  METHODS
  Immunohistochemical staining of CPEB4 and estrogen receptor, progesterone receptor, and human epidermal growth factor receptor was performed in 107 invasive ductal carcinoma (IDC) samples, and prognostic significance was evaluated.
  
  
  RESULTS
  High expression of CPEB4 was observed in 48.6% of IDC samples. Elevated CPEB4 expression was possibly related to increased histological grading (P=0.037) and N stage (P<0.001). Patients with high expression of CPEB4 showed shorter overall survival (P=0.001). High CPEB4 expression was an independent prognostic factor for overall survival (P=0.022, hazard ratio =4.344, 95% confidence interval =1.235-15.283).
  
  
  CONCLUSIONS
  High CPEB4 expression is associated with increased histological grading and N stage, and it can serve as an independent prognostic factor in IDC.
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China ; Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Hao-Ting
authors.initials: HT
authors.lastname: Sun
authors.affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Canton, Guangdong Province, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wen
authors.affiliation: Key Lab of Myopia, Ministry of Health, Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, People's Republic of China.
authors.forename: Tian
authors.initials: T
authors.lastname: Han
authors.affiliation: Urology Department and Institute of Urology, Peking University First Hospital, Peking University, Beijing, People's Republic of China.
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Liu
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China.
authors.forename: Shao-Bo
authors.initials: SB
authors.lastname: Li
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China.
authors.forename: Ji-Gang
authors.initials: JG
authors.lastname: Wang
authors.affiliation: Department of Pathology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, People's Republic of China.
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Liu
keywords: cytoplasmic polyadenylation element binding protein 4; immunohistochemistry; invasive ductal carcinoma; prognosis