title: Estimation of high sensitivity C-reactive protein in patients with periodontal disease and without coronary artery disease.
abstract: BACKGROUND
  HsCRP (Highly sensitive C reactive protein) is a global indicator for future vascular events in adults detected in blood stream 48 hours before the cardiovascular event. Periodontal disease may increase blood levels of inflammatory markers like IL-6, CRP and HsCRP. Hence the aim of the present study is to evaluate the presence of elevated HsCRP levels in chronic periodontitis patients.
  
  
  METHODS
  100 patients who reported for cardiac master health check up were enrolled in the study. The periodontal status was assessed using periodontal probing pocket depth and clinical attachment level. The decayed, missing and filled tooth was recorded using DMFT index. The venous samples of these patients were obtained for recording HsCRP levels.
  
  
  RESULTS
  Pearson correlation was used to analyze the relationship between HsCRP level and probing pocket depth, clinical attachment loss and DMFT. The correlation value was 0.051, 0.025 and 0.101 respectively, the correlation is statistically significant for probing pocket depth and clinical attachment level (P>0.05). Chi-square test was performed to study the association between gender and HsCRP, Diabetes Mellitus and HsCRP and Hypertension and HsCRP; the results showed that there is no significant association between any of the above mentioned factors and HsCRP level in blood.
  
  
  CONCLUSIONS
  We found an increased level of HsCRP in patients with chronic periodontitis which revealed the susceptibility of these patients to cardiac diseases like myocardial infarction and stroke. Hence present day focus in the line of management of cardiac patient has changed from the periodontal perspective.
authors.affiliation: Department of Periodontics, Chettinad Dental College and Research Institute, Kanchipuram, Tamil Nadu, India.
authors.forename: V
authors.initials: V
authors.lastname: Anitha
authors.forename: Sushma
authors.initials: S
authors.lastname: Nair
authors.forename: V
authors.initials: V
authors.lastname: Shivakumar
authors.forename: M
authors.initials: M
authors.lastname: Shanmugam
authors.forename: B Meena
authors.initials: BM
authors.lastname: Priya
authors.forename: P
authors.initials: P
authors.lastname: Rajesh
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D010510:Periodontal Diseases / Q000097:blood* / Q000150:complications; D012680:Sensitivity and Specificity
chemical_list: D002097:C-Reactive Protein