title: Atypical cartilaginous tumor/chondrosarcoma, grade 1, of the mastoid in three family members: A new entity.
abstract: We present a case series of a family with three members having cartilaginous tumors of the mastoid. All patients presented between the ages of 9 to 12 years with acute onset facial nerve paralysis. Histologic analysis of all tumors showed similar features, consistent with atypical cartilaginous tumors/chondrosarcoma, low-grade. Conventional cytogenetic analysis performed on one of the sons' tumor showed no evidence of chromosomal abnormality. High-resolution array comparative genomic hybridization performed on the same patient's blood also showed no unbalanced chromosomal abnormality. This is the first report of family members with this unusual combination of clinical, radiologic, and histologic finding. Laryngoscope, 126:E310-E313, 2016.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Frisch
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Carrie Y
authors.initials: CY
authors.lastname: Inwards
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Lalich
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Jodi M
authors.initials: JM
authors.lastname: Carter
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, U.S.A.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Neff
mesh_terms: D002648:Child; D002813:Chondrosarcoma / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008416:Mastoid; D060787:Neoplasm Grading; D012888:Skull Neoplasms / Q000235:genetics* / Q000473:pathology
keywords: Temporal bone tumor; chondrosarcoma; mastoid tumor; temporal bone cartilaginous tumor; temporal bone chondrosarcoma