title: A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1.
abstract: PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protein S100A4 (Mts1), providing a number of novel cellular functions. Here we show that Tag7-Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. Cells of either innate immunity (neutrophils and monocytes) or acquired immunity (CD4(+) and CD8(+) lymphocytes) can produce this complex, which confirms the close connection between components of the 2 branches of immune response.
authors.affiliation: a Institute of Gene Biology; Russian Academy of Sciences (RAS) ; Moscow , Russia.|b Engelhardt Institute of Molecular Biology; RAS ; Moscow , Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Dukhanina
authors.affiliation: a Institute of Gene Biology; Russian Academy of Sciences (RAS) ; Moscow , Russia.|c M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry; RAS ; Moscow , Russia.
authors.forename: T I
authors.initials: TI
authors.lastname: Lukyanova
authors.affiliation: a Institute of Gene Biology; Russian Academy of Sciences (RAS) ; Moscow , Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Romanova
authors.affiliation: d School of Animal and Comparative Biomedical Sciences; University of Arizona ; Tucson , AZ USA.
authors.forename: V
authors.initials: V
authors.lastname: Guerriero
authors.affiliation: a Institute of Gene Biology; Russian Academy of Sciences (RAS) ; Moscow , Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Gnuchev
authors.affiliation: a Institute of Gene Biology; Russian Academy of Sciences (RAS) ; Moscow , Russia.
authors.forename: G P
authors.initials: GP
authors.lastname: Georgiev
authors.affiliation: a Institute of Gene Biology; Russian Academy of Sciences (RAS) ; Moscow , Russia.
authors.forename: D V
authors.initials: DV
authors.lastname: Yashin
authors.affiliation: a Institute of Gene Biology; Russian Academy of Sciences (RAS) ; Moscow , Russia.
authors.forename: L P
authors.initials: LP
authors.lastname: Sashchenko
mesh_terms: D056704:Adaptive Immunity; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D002469:Cell Separation; D002634:Chemotaxis, Leukocyte / Q000235:genetics / Q000276:immunology*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D016207:Cytokines / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D004926:Escherichia coli; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D009000:Monocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D061251:Primary Cell Culture; D011485:Protein Binding; D011994:Recombinant Proteins; D015398:Signal Transduction
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16; D016207:Cytokines; C491878:PGLYRP1 protein, human; D011994:Recombinant Proteins
keywords: Mts1; NK cells; Tag7; Tag7-Mts1 complex; chemotaxis; human lymphocytes