title: Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine.
abstract: A bone imaging toolkit of 21 fluorescent probes with variable spectroscopic properties, bone mineral binding affinities, and antiprenylation activities has been created, including a novel linking strategy. The linking chemistry allows attachment of a diverse selection of dyes fluorescent in the visible to near-infrared range to any of the three clinically important heterocyclic bisphosphonate bone drugs (risedronate, zoledronate, and minodronate or their analogues). The resultant suite of conjugates offers multiple options to "mix and match" parent drug structure, fluorescence emission wavelength, relative bone affinity, and presence or absence of antiprenylation activity, for bone-related imaging applications.
authors.affiliation: Department of Chemistry, University of Southern California , Los Angeles, California 90089, United States.|BioVinc LLC , 6162 Bristol Parkway, Culver City, California 90230, United States.
authors.forename: Shuting
authors.initials: S
authors.lastname: Sun
authors.affiliation: Department of Chemistry, University of Southern California , Los Angeles, California 90089, United States.|Faculty of Chemistry, Lodz University of Technology , Zeromskiego 116, 90-924 Lodz, Poland.
authors.forename: Katarzyna M
authors.initials: KM
authors.lastname: Błażewska
authors.affiliation: Department of Chemistry, University of Southern California , Los Angeles, California 90089, United States.
authors.forename: Anastasia P
authors.initials: AP
authors.lastname: Kadina
authors.affiliation: Department of Chemistry, University of Southern California , Los Angeles, California 90089, United States.
authors.forename: Boris A
authors.initials: BA
authors.lastname: Kashemirov
authors.affiliation: Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford , Nuffield Orthopaedic Centre, Oxford, OX3 7LD, United Kingdom.
authors.forename: Xuchen
authors.initials: X
authors.lastname: Duan
authors.affiliation: Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford , Nuffield Orthopaedic Centre, Oxford, OX3 7LD, United Kingdom.
authors.forename: James T
authors.initials: JT
authors.lastname: Triffitt
authors.affiliation: Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford , Nuffield Orthopaedic Centre, Oxford, OX3 7LD, United Kingdom.
authors.forename: James E
authors.initials: JE
authors.lastname: Dunford
authors.affiliation: Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford , Nuffield Orthopaedic Centre, Oxford, OX3 7LD, United Kingdom.
authors.forename: R Graham G
authors.initials: RG
authors.lastname: Russell
authors.affiliation: BioVinc LLC , 6162 Bristol Parkway, Culver City, California 90230, United States.
authors.forename: Frank H
authors.initials: FH
authors.lastname: Ebetino
authors.affiliation: Musculoskeletal Research Programme, Institute of Medical Sciences, University of Aberdeen , Aberdeen, AB25 2ZD, United Kingdom.
authors.forename: Anke J
authors.initials: AJ
authors.lastname: Roelofs
authors.affiliation: Musculoskeletal Research Programme, Institute of Medical Sciences, University of Aberdeen , Aberdeen, AB25 2ZD, United Kingdom.
authors.forename: Fraser P
authors.initials: FP
authors.lastname: Coxon
authors.affiliation: BioVinc LLC , 6162 Bristol Parkway, Culver City, California 90230, United States.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Lundy
authors.affiliation: Department of Chemistry, University of Southern California , Los Angeles, California 90089, United States.
authors.forename: Charles E
authors.initials: CE
authors.lastname: McKenna
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000175:diagnosis*; D001842:Bone and Bones / Q000473:pathology*; D002460:Cell Line; D004164:Diphosphonates / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D008297:Male; D061848:Optical Imaging / Q000379:methods*; D017207:Rats, Sprague-Dawley
chemical_list: D004164:Diphosphonates; D005456:Fluorescent Dyes