title: Antihyperglycemic effect of thymoquinone and oleuropein, on streptozotocin-induced diabetes mellitus in experimental animals.
abstract: BACKGROUND
  Diabetes mellitus is one of the most important diseases related with endocrines. Its main manifestation includes abnormal metabolism of carbohydrates and lipids and inappropriate hyperglycemia that is caused by absolute or relative insulin deficiency. It affects humankind worldwide.
  
  
  OBJECTIVE
  Our research was aimed to observe antihyperglycemic activity of thymoquinone and oleuropein.
  
  
  METHODS
  In this study, rats were divided into six groups, 6 rats in each. Diabetes was inducted by streptozotocin (STZ). The level of fasting blood glucose was determined for each rats during the experiment, doses of thymoquinone and oleuropein (3 mg/kg and 5 mg/kg) for both, were injected intraperitoneal. Pancreatic tissues were investigated to compare β-cells in diabetic and treated rats.
  
  
  CONCLUSIONS
  It was found that thymoquinone and oleuropein significantly decrease serum Glucose levels in STZ induced diabetic rats.
authors.affiliation: Department of Clinical Pharmacy, College of Pharmacy, Northern Borders University, Rafha, Kingdom of Saudi Arabia.
authors.forename: Sibghatullah Muhammad Ali
authors.initials: SM
authors.lastname: Sangi
authors.affiliation: Department of Clinical Pharmacy, College of Pharmacy, Northern Borders University, Rafha, Kingdom of Saudi Arabia.
authors.forename: Mansour Ibrahim
authors.initials: MI
authors.lastname: Sulaiman
authors.affiliation: Department of Clinical Pharmacy, College of Pharmacy, Northern Borders University, Rafha, Kingdom of Saudi Arabia.
authors.forename: Mohammed Fawzy Abd
authors.initials: MF
authors.lastname: El-Wahab
authors.affiliation: Department of Clinical Pharmacy, College of Pharmacy, Northern Borders University, Rafha, Kingdom of Saudi Arabia.
authors.forename: Elsamoual Ibrahim
authors.initials: EI
authors.lastname: Ahmedani
authors.affiliation: King Fahad Medical Research center, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
authors.forename: Soad Shaker
authors.initials: SS
authors.lastname: Ali
keywords: Diabetes mellitus; oleuropein; streptozotocin; thymoquinone