title: Two New Cyclic Depsipeptides from the Endophytic Fungus Fusarium sp.
abstract: Two new cyclic depsipeptides, W493 C (1) and D (2), along with two known derivatives W493 A (3) and B (4) were obtained from the endophytic fungus Fusarium sp. isolated from the Mangrove plant Ceriops tagal. The structures of the new compounds were determined on the basis of one- and two dimensional NMR and high-resolution mass spectroscopic data. The absolute configurations of the amino acid residues of 1 and 2 were confirmed by application of Marfey's method. W493 A (3) and B (4) exhibited moderate activity against the fungus Cladosporium cladosporiodes and weak antitumor activity against the human ovarian cancer cell line A2780.
authors.forename: Fang
authors.initials: F
authors.lastname: Lv
authors.forename: Georgios
authors.initials: G
authors.lastname: Daletos
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D047630:Depsipeptides / Q000737:chemistry* / Q000378:metabolism; D060026:Endophytes / Q000737:chemistry*; D005670:Fusarium / Q000737:chemistry*; D015394:Molecular Structure; D043982:Rhizophoraceae / Q000382:microbiology
chemical_list: D047630:Depsipeptides