title: Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases.
abstract: Matrix metalloproteinase-8 is a promising candidate biomarker for oral fluid (gingival crevicular fluid, peri-implant sulcular fluid and saliva) and mouthrinse chair-side/point-of-care diagnostics to predict, diagnose and determine the progressive phases of episodic periodontitis and peri-implantitis, as well as to monitor the treatments and medications. Matrix metalloproteinase-8 can be used alone or together with interleukin-1beta and Porphyromonas gingivalis to calculate cumulative risk score at the subject level as a successful diagnostic tool, especially in large-scale public health surveys, in which a thorough periodontal examination is not feasible.
authors.forename: Timo
authors.initials: T
authors.lastname: Sorsa
authors.forename: Ulvi K
authors.initials: UK
authors.lastname: Gursoy
authors.forename: Solomon
authors.initials: S
authors.lastname: Nwhator
authors.forename: Marcela
authors.initials: M
authors.lastname: Hernandez
authors.forename: Taina
authors.initials: T
authors.lastname: Tervahartiala
authors.forename: Jussi
authors.initials: J
authors.lastname: Leppilahti
authors.forename: Mervi
authors.initials: M
authors.lastname: Gursoy
authors.forename: Eija
authors.initials: E
authors.lastname: Könönen
authors.forename: Gulnur
authors.initials: G
authors.lastname: Emingil
authors.forename: Pirkko J
authors.initials: PJ
authors.lastname: Pussinen
authors.forename: Päivi
authors.initials: P
authors.lastname: Mäntylä
mesh_terms: D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D003945:Diagnosis, Oral / Q000379:methods; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry* / Q000201:enzymology*; D006801:Humans; D008297:Male; D020784:Matrix Metalloproteinase 8 / Q000032:analysis* / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000032:analysis* / Q000494:pharmacology; D010510:Periodontal Diseases / Q000175:diagnosis / Q000201:enzymology*; D011247:Pregnancy; D012463:Saliva / Q000737:chemistry / Q000201:enzymology*
chemical_list: D015415:Biomarkers; D020782:Matrix Metalloproteinases; C488762:MMP8 protein, human; D020784:Matrix Metalloproteinase 8