title: Primary tumour characteristics predict the invasiveness of lymph node metastases in papillary thyroid carcinoma patients.
abstract: OBJECTIVE
  This study evaluated whether primary tumour characteristics are associated with specific features of metastatic lymph nodes in papillary thyroid carcinoma patients.
  
  
  METHODS
  A retrospective review of 411 patients with pathologically diagnosed cervical lymph node metastasis was conducted.
  
  
  RESULTS
  A metastatic lymph node focus size of at least 2 mm was independently associated with a primary tumour size of at least 1 cm (hazard ratio 1.962) and with male sex (hazard ratio 1.947). A number of at least five lymph node metastases was independently associated with a primary tumour size of at least 1 cm (hazard ratio 2.863), extrathyroidal extension (hazard ratio 1.737) and male sex (hazard ratio 1.689). Extranodal extension was independently associated with a primary tumour size of at least 1 cm (hazard ratio 2.288), extrathyroidal extension (2.201) and male sex (hazard ratio 1.733).
  
  
  CONCLUSIONS
  Primary papillary thyroid carcinoma characteristics are related to the pathological features of lymph node metastases.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Kosin University College of Medicine,Busan,Korea.
authors.forename: H S
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Kosin University College of Medicine,Busan,Korea.
authors.forename: C
authors.initials: C
authors.lastname: Park
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Kosin University College of Medicine,Busan,Korea.
authors.forename: S W
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Kosin University College of Medicine,Busan,Korea.
authors.forename: J W
authors.initials: JW
authors.lastname: Song
authors.affiliation: Department of Pathology,Kosin University College of Medicine,Busan,Korea.
authors.forename: B K
authors.initials: BK
authors.lastname: Chun
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Maryknoll Medical Center,Busan,Korea.
authors.forename: T J
authors.initials: TJ
authors.lastname: Park
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Dong-A University College of Medicine,Busan,Korea.
authors.forename: J C
authors.initials: JC
authors.lastname: Hong
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Kosin University College of Medicine,Busan,Korea.
authors.forename: K D
authors.initials: KD
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery; D002291:Carcinoma, Papillary; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy / Q000706:statistics & numerical data; D047368:Tumor Burden; D055815:Young Adult
keywords: Lymph Nodes; Lymphatic Metastasis; Pathology; Thyroid Neoplasms