title: Piracy on the molecular level: human herpesviruses manipulate cellular chemotaxis.
abstract: Cellular chemotaxis is important to tissue homeostasis and proper development. Human herpesvirus species influence cellular chemotaxis by regulating cellular chemokines and chemokine receptors. Herpesviruses also express various viral chemokines and chemokine receptors during infection. These changes to chemokine concentrations and receptor availability assist in the pathogenesis of herpesviruses and contribute to a variety of diseases and malignancies. By interfering with the positioning of host cells during herpesvirus infection, viral spread is assisted, latency can be established and the immune system is prevented from eradicating viral infection.
authors.affiliation: Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA.
authors.forename: Caleb
authors.initials: C
authors.lastname: Cornaby
authors.affiliation: Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Tanner
authors.affiliation: Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA.
authors.forename: Eric W
authors.initials: EW
authors.lastname: Stutz
authors.affiliation: Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Poole
authors.affiliation: Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA.
authors.forename: Bradford K
authors.initials: BK
authors.lastname: Berges
mesh_terms: D000818:Animals; D018925:Chemokines / Q000235:genetics / Q000276:immunology; D002633:Chemotaxis; D006564:Herpesviridae / Q000235:genetics / Q000502:physiology*; D006566:Herpesviridae Infections / Q000235:genetics / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D019707:Receptors, Chemokine / Q000235:genetics / Q000276:immunology
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine