title: Association of common variants in TOMM40/APOE/APOC1 region with human longevity in a Chinese population.
abstract: Apolipoprotein E (APOE), translocase of outer mitochondrial membrane 40 homolog (TOMM40) and apolipoprotein C-I (APOC1) may extend lifespan by marked delay or escape from age-related diseases. This study aimed to elucidate the association of human longevity with genetic variations in TOMM40/APOE/APOC1 region in a Chinese population. Ten tag single-nucleotide polymorphisms (SNPs) in the TOMM40/APOE/APOC1 region were successfully genotyped in 616 unrelated long-lived individuals and 846 younger controls. Of the 10 SNPs, rs7254892 in 5' upstream of TOMM40 showed significant association with human longevity (G/A-A/A vs G/G: odds ratio (OR)=1.59, 95% confidence interval (CI)=1.20-2.09, P=0.0011, Bonferroni corrected P (Pc)=0.033). The haplotype analysis suggested that individuals carrying the haplotype A-A-A-A-T-A-T-G-C-A (rs7254892-rs157580-rs2075649-rs2075650-rs157582-rs8106922-rs1160985-rs405697-rs439401-rs445925) tended to have longer lifespan than those carrying the most common haplotype G-G-A-A-C-A-C-A-T-G (OR=1.59, 95% CI=1.19-2.12, P=0.0018, Pc=0.0216). These findings indicated that variants in TOMM40/APOE/APOC1 region might be associated with human longevity. Further studies are needed to identify the causal genetic variants influencing human longevity.
authors.affiliation: Department of Biology, Hainan Medical College, Haikou, Hainan, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Lin
authors.affiliation: Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, Hainan, China.
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, Hainan, China.
authors.forename: Dongjing
authors.initials: D
authors.lastname: Yan
authors.affiliation: Department of Neurology, the Affiliated Hospital of Hainan Medical College, Haikou, Hainan, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Liao
authors.affiliation: Department of Biology, Hainan Medical College, Haikou, Hainan, China.
authors.forename: Gu
authors.initials: G
authors.lastname: Gong
authors.affiliation: Department of Biology, Hainan Medical College, Haikou, Hainan, China.|College of Agriculture, Hainan University, Haikou, Hainan, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Hu
authors.affiliation: Division of Biostatistics and Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX, USA.
authors.forename: Yunxin
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, Hainan, China.
authors.forename: Wangwei
authors.initials: W
authors.lastname: Cai
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000235:genetics; D053302:Apolipoprotein C-I / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics*; D008875:Middle Aged; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D020641:Polymorphism, Single Nucleotide
chemical_list: C505803:APOC1 protein, human; D053302:Apolipoprotein C-I; D001057:Apolipoproteins E; D026901:Membrane Transport Proteins; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; C400783:TOMM40 protein, human