title: microRNAs Distinctively Regulate Vascular Smooth Muscle and Endothelial Cells: Functional Implications in Angiogenesis, Atherosclerosis, and In-Stent Restenosis.
abstract: Endothelial cells (EC) and vascular smooth muscle cells (VSMC) are the main cell types within the vasculature. We describe here how microRNAs (miRs)--noncoding RNAs that can regulate gene expression via translational repression and/or post-transcriptional degradation--distinctively modulate EC and VSMC function in physiology and disease. In particular, the specific roles of miR-126 and miR-143/145, master regulators of EC and VSMC function, respectively, are deeply explored. We also describe the mechanistic role of miRs in the regulation of the pathophysiology of key cardiovascular processes including angiogenesis, atherosclerosis, and in-stent restenosis post-angioplasty. Drawbacks of currently available therapeutic options are discussed, pointing at the challenges and potential clinical opportunities provided by miR-based treatments.
authors.affiliation: Columbia University Medical Center, New York, NY, USA. gsantulli001@gmail.com.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Santulli
mesh_terms: D017130:Angioplasty; D000818:Animals; D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology* / Q000378:metabolism; D005786:Gene Expression Regulation; D006083:Graft Occlusion, Vascular / Q000235:genetics / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000502:physiology*; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D018919:Neovascularization, Physiologic; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism*; D015607:Stents / Q000009:adverse effects; D066253:Vascular Remodeling
chemical_list: D035683:MicroRNAs; D022661:RNA, Untranslated
keywords: Angiogenesis; Angioplasty; Atherosclerosis; Circulation; DES; Diabetes; Endothelium; Inflammation; Myocardin; Myoregulin; Neointima; Restenosis; Stent; Thrombosis; VSMC; miR-126; miR-143/145