title: Viral chemistry: the chemical functionalization of viral architectures to create new technology.
abstract: The modification of viruses using chemical conjugation techniques has brought the distant worlds of virology right into the center of nanotechnology. Viruses are naturally resilient biomolecules and this makes them exceptional templates for the creation of higher order polymers and as scaffolds for biological imaging and targeted drug delivery. In this review, we highlight progress in utilizing chemical strategies to interface viruses with synthetic polymers, to create bright bionanoparticles using synthetic fluorescent dyes, and how orthogonal chemical transformations allow for targeted drug delivery. WIREs Nanomed Nanobiotechnol 2016, 8:512-534. doi: 10.1002/wnan.1379 For further resources related to this article, please visit the WIREs website.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.
authors.forename: Shaobo
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.
authors.forename: Madushani
authors.initials: M
authors.lastname: Dharmarwardana
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Schlimme
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.
authors.forename: Jeremiah J
authors.initials: JJ
authors.lastname: Gassensmith
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes; D006801:Humans; D051379:Mice; D057054:Molecular Imaging; D050997:Nanomedicine; D014780:Viruses
chemical_list: D005456:Fluorescent Dyes