title: Two new diacetylene glycosides: bhutkesoside A and B from the roots of Ligusticopsis wallichiana.
abstract: Two new diacetylene glycosides: bhutkesoside A (1) and B (2), along with 10 known compounds, i.e. falcarindiol (3), chlorogenic acid (4), 5-O-p-coumaroyl-quinic acid (5), 3,5-di-O-caffeoyl-quinic acid (6), 4-hydroxy-7-methoxy-phenylethanol (7), ferulic acid (8), dehydrodiconiferyl alcohol-4-O-β-d-glucopyranoside (9), 5,7-dihydroxy-2-methylchromone-7-O-rutinoside (10), schumanniofioside B (11) and marmesinin (12) were isolated from the roots of Ligusticopsis wallichiana (DC) Pimenov & Kljuykov (Apiaceae), commonly known as 'Bhutkesh' in Nepal. The structures were determined on the basis of spectroscopic data. Compounds 4 and 6 showed potent antioxidant activity on DPPH free radical scavenging assay.
authors.affiliation: a Graduate School of Pharmaceutical Sciences , Kumamoto University , Kumamoto , Japan.|b Program for Leading Graduate Schools, HIGO Program , Kumamoto University , Kumamoto , Japan.
authors.forename: Bibek
authors.initials: B
authors.lastname: Adhikari
authors.affiliation: a Graduate School of Pharmaceutical Sciences , Kumamoto University , Kumamoto , Japan.|b Program for Leading Graduate Schools, HIGO Program , Kumamoto University , Kumamoto , Japan.
authors.forename: Hari Prasad
authors.initials: HP
authors.lastname: Devkota
authors.affiliation: a Graduate School of Pharmaceutical Sciences , Kumamoto University , Kumamoto , Japan.
authors.forename: Khem Raj
authors.initials: KR
authors.lastname: Joshi
authors.affiliation: a Graduate School of Pharmaceutical Sciences , Kumamoto University , Kumamoto , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: a Graduate School of Pharmaceutical Sciences , Kumamoto University , Kumamoto , Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Yahara
mesh_terms: D019661:Apiaceae / Q000737:chemistry*; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D009390:Nepal; D010851:Picrates; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006027:Glycosides; D010851:Picrates; D010936:Plant Extracts; C000617279:bhutkesoside A; C000617280:bhutkesoside B; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Apiaceae; Bhutkesh; Ligusticopsis wallichiana; bhutkesoside A; bhutkesoside B