title: microRNAs and Endometrial Pathophysiology.
abstract: Embryo implantation requires a reciprocal interaction between the blastocyst and endometrium and is associated with complex regulatory mechanisms. Since their discovery, microRNAs became prominent candidates providing missing links for many biological pathways. In recent years, microRNAs were implicated as one of the important players in regulation of various biological and physiological endometrial related processes. This chapter aims to present recent knowledge pertaining to the diverse aspects of microRNAs in the embryo-endometrial relationship. We will focus on the role of microRNAs in decidualization and their part in natural and stimulated cycles. Next, we will present recent studies deliberating the role of microRNAs in recurrent pregnancy loss and in the important phenomenon of recurrent implantation failure. Lastly, demonstrating an important aspect of embryo implantation and invasion, we will outline few microRNA related shared pathways of implantation and carcinogenesis.
authors.affiliation: Department of Obstetrics and Gynecology, The Hebrew University-Hadassah Medical Center, POB 12272, Jerusalem, 91120, Israel. Henchill@gmail.com.
authors.forename: Henry H
authors.initials: HH
authors.lastname: Chill
authors.affiliation: Department of Obstetrics and Gynecology, The Hebrew University-Hadassah Medical Center, POB 12272, Jerusalem, 91120, Israel.
authors.forename: Uri P
authors.initials: UP
authors.lastname: Dior
authors.affiliation: Department of Obstetrics and Gynecology, The Hebrew University-Hadassah Medical Center, POB 12272, Jerusalem, 91120, Israel.
authors.forename: Liron
authors.initials: L
authors.lastname: Kogan
authors.affiliation: Department of Obstetrics and Gynecology, The Hebrew University-Hadassah Medical Center, POB 12272, Jerusalem, 91120, Israel.
authors.forename: Ariel
authors.initials: A
authors.lastname: Revel
mesh_terms: D000026:Abortion, Habitual; D000818:Animals; D003656:Decidua / Q000378:metabolism / Q000503:physiopathology; D010064:Embryo Implantation; D020964:Embryo Loss / Q000235:genetics* / Q000503:physiopathology*; D004717:Endometrium / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D011247:Pregnancy
chemical_list: D035683:MicroRNAs
keywords: Angiogenesis; Decidualization; Endometrium; Gynecology; Immunomodulation; Implantation; Pregnancy