title: The Role of Arginine-Phenylalanine-Amide-Related Peptides in Mammalian Reproduction.
abstract: Until 2000 it was believed that gonadotropin-releasing hormone (GnRH) was the sole regulator of hypophyseal gonadotropes. In 2000, the discovery of a gonadotropin inhibitory hormone (GnIH) initiated a revolution in the field of reproductive physiology. Identification of GnIH homologues in mammals, the arginine-phenylalanine-amide (RFamide)-related peptides (RFRPs), indicated a similar function. Subsequently, further works conducted in various laboratories worldwide have shown that these neuropeptides inhibit the hypothalamic-hypophyseal axis. This review discusses the role of RFRPs in mammalian reproductive processes.
authors.affiliation: Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran.
authors.forename: Mohammad Saied
authors.initials: MS
authors.lastname: Salehi
authors.affiliation: Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Amin
authors.initials: A
authors.lastname: Tamadon
authors.affiliation: Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Jafarzadeh Shirazi
authors.affiliation: Histomorphometry and Stereology Research Center, Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Namavar
authors.affiliation: Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Zamiri
keywords: Gonadotropin Inhibitory Hormone; Mammals; RFamide-Related Peptide; Reproduction