title: [Acute kidney injury and renal replacement therapy in victims from out-of-hospital cardiac arrest with administration of contrast agent].
abstract: BACKGROUND
  Early coronary angiography and computed tomography are recommended in survivors of out-of-hospital cardiac arrest (OHCA). However, both techniques require iodinated contrast agent although the effects on incident acute kidney injury are unknown. The aim of this study was to explore the incidence of acute kidney injuries (AKI) and need for renal replacement therapy (RRT) in patients after nontraumatic OHCA with special regard to the administration of contrast agent during the early in-hospital diagnostic workup.
  
  
  METHODS
  Data from all survivors of OHCA admitted to our hospital between 1 January 2008 and 30 June 2015 were retrospectively collected. Incidence of AKI and RRT between the contrast and no contrast groups were compared.
  
  
  RESULTS
  Of 280 OHCA survivors, 133 (47.5 %) received contrast agent (227.0 ± 136.5 ml). Within 72 h after hospital admission, 47 of 129 survivors (36.4 %) developed AKI of any stage, but AKI was more common in patients without early contrast administration than in patients with early contrast administration (54.5 vs. 28.2 %; p = 0.011). Patients who survived until hospital discharge had higher serum creatinine levels at admission than at hospital discharge (1.17 ± 0.37 vs. 0.92 ± 0.35; p < 0.001).
  
  
  CONCLUSIONS
  AKI is common in survivors of OHCA, and RRT following OHCA is needed more frequently than in other cardiac disease. Despite elevated serum creatinine levels at admission, we could not show an association between early contrast administration in survivors of OHCA and AKI incidence.
authors.affiliation: Medizinische Klinik II (Schwerpunkt Kardiologie und Angiologie), Marienhospital Herne, Ruhr - Universität Bochum, Hölkeskampring 40, 44625, Herne, Deutschland. martin.christ@marienhospital-herne.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Christ
authors.affiliation: Medizinische Klinik II (Schwerpunkt Kardiologie und Angiologie), Marienhospital Herne, Ruhr - Universität Bochum, Hölkeskampring 40, 44625, Herne, Deutschland.
authors.forename: Katharina Isabel
authors.initials: KI
authors.lastname: Auenmüller
authors.affiliation: Medizinische Klinik II (Schwerpunkt Kardiologie und Angiologie), Marienhospital Herne, Ruhr - Universität Bochum, Hölkeskampring 40, 44625, Herne, Deutschland.
authors.forename: Scharbanu
authors.initials: S
authors.lastname: Amirie
authors.affiliation: Medizinische Klinik II (Schwerpunkt Kardiologie und Angiologie), Marienhospital Herne, Ruhr - Universität Bochum, Hölkeskampring 40, 44625, Herne, Deutschland.
authors.forename: Michael
authors.initials: M
authors.lastname: Brand
authors.affiliation: Medizinische Klinik II (Schwerpunkt Kardiologie und Angiologie), Marienhospital Herne, Ruhr - Universität Bochum, Hölkeskampring 40, 44625, Herne, Deutschland.
authors.forename: Benjamin Michel
authors.initials: BM
authors.lastname: Sasko
authors.affiliation: Medizinische Klinik II (Schwerpunkt Kardiologie und Angiologie), Marienhospital Herne, Ruhr - Universität Bochum, Hölkeskampring 40, 44625, Herne, Deutschland.
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Trappe
mesh_terms: D058186:Acute Kidney Injury / Q000000981:diagnostic imaging / Q000401:mortality* / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care / Q000706:statistics & numerical data*; D015984:Causality; D015897:Comorbidity; D003287:Contrast Media; D017023:Coronary Angiography / Q000401:mortality / Q000706:statistics & numerical data; D016757:Death, Sudden, Cardiac / Q000453:epidemiology* / Q000517:prevention & control; D019317:Evidence-Based Medicine; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D017582:Renal Replacement Therapy / Q000401:mortality* / Q000706:statistics & numerical data; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003287:Contrast Media
keywords: Computed tomography; Coronary angiography; Coronary intervention; Dialysis; Serum creatinine