title: [Association between CCND1 G870A polymorphism and radiotherapy response in high-risk human papillomavirus-related cervical cancer].
abstract: OBJECTIVE
  To investigate the correlation of cyclin D1 (CCND1) G870A single nucleotide polymorphism (SNP) with radiotherapy response in patients with high risk human papillomavirus (HR-HPV) related cervical cancer.
  
  
  METHODS
  A total of 273 patients with cervical cancer, who were confirmed by histopathology and hybrid capture 2 (HC-2) assay and treated by radiotherapy, were enrolled for this study. The correlation of CCND1 G870A polymorphism with tumor response in patients was assessed.
  
  
  RESULTS
  Compared with patients with AA genotype, the patients with GG genotype and AA genotype showed lower sensitivity to radio-therapy treatment (adjusted ORGA=2.69, 95% CI 1.28-5.67 and adjusted ORGG=3.28, 95% CI 1.47-7.29, respectively), an increase in risks of recurrence/metastasis (adjusted ORGA=2.52, 95% CI 1.12-5.63 and adjusted ORGG=3.95, 95% CI 1.68-9.26, respectively), and shorter recurrence/metastasis-free survival (PGA=0.010 and PGG=0.045).
  
  
  CONCLUSIONS
  G870A polymorphism is a frequent variation that could be used for evaluate the radio-sensitivity and prognosis for patients with HR-HPV related cervical cancer.
authors.affiliation: Department of Radiotherapy, Tumor Hosipital of the First People's Hospital of Foshan, Foshan Guangdong 528000, China lsqwenzhang@aliyun.com.
authors.forename: Shaoqiang
authors.initials: S
authors.lastname: Liang
authors.affiliation: Department of Radiotherapy, Tumor Hosipital of the First People's Hospital of Foshan, Foshan Guangdong 528000, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Radiotherapy, Tumor Hosipital of the First People's Hospital of Foshan, Foshan Guangdong 528000, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.affiliation: Department of Radiotherapy, Tumor Hosipital of the First People's Hospital of Foshan, Foshan Guangdong 528000, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of Radiotherapy, Tumor Hosipital of the First People's Hospital of Foshan, Foshan Guangdong 528000, China.
authors.forename: Lusi
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Radiotherapy, Tumor Hosipital of the First People's Hospital of Foshan, Foshan Guangdong 528000, China.
authors.forename: Zhiqian
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Radiotherapy, Tumor Hosipital of the First People's Hospital of Foshan, Foshan Guangdong 528000, China.
authors.forename: Shaoen
authors.initials: S
authors.lastname: Li
mesh_terms: D019938:Cyclin D1 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D027383:Papillomaviridae; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000532:radiotherapy* / Q000821:virology
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1