title: Fabrication and formation studies on single-walled CA/NaCS-WSC microcapsules.
abstract: The micron-sized calcium alginate/sodium cellulose sulfate-water soluble chitosan (CA/NaCS-WSC) microcapsules were prepared by membrane emulsification method using sodium alginate (NaAlg), NaCS and WSC as raw materials. The CA/NaCS microspheres prepared dispersed well and held spherical shape with an emulsifier volume ratio of 7:3 (Span 80:Tween 80) and a concentration of cross-linking agent of 1.5% (w/v) calcium chloride and 5% (w/v) sodium chloride. The CA/NaCS-WSC microcapsules had a spherical shape with average diameter of 62.36±13.87μm. A fluorescent ring could be seen obviously on the surface of CA/NaCS-WSC microcapsules under confocal microscope, when WSC was labeled by fluorescein isothiocyanate. The discussion on the formation studies implied that Ca(2+) could diffuse into the droplets of NaAlg/NaCS forming CA/NaCS microspheres, while NaCS could react with WSC forming a polyelectrolyte complexes film. The microcapsules prepared with typical wall-capsule/core structure could be used to develop micron-sized drug delivery carriers.
authors.affiliation: Key Laboratory of Eco-engineering and Biotechnology of Anhui Province, Integrated Biotechnology Laboratory, School of Life Sciences, Anhui University, Hefei 230601, China; Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Qing-Xi
authors.initials: QX
authors.lastname: Wu
authors.affiliation: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China.
authors.forename: Dong-Qiang
authors.initials: DQ
authors.lastname: Lin
authors.affiliation: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China. Electronic address: yaosj@zju.edu.cn.
authors.forename: Shan-Jing
authors.initials: SJ
authors.lastname: Yao
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002214:Capsules / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003432:Cross-Linking Reagents; D004337:Drug Carriers / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008422:Materials Testing
chemical_list: D000464:Alginates; D002214:Capsules; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D004655:Emulsions; D006603:Hexuronic Acids; C400945:water soluble chitin; D020723:Glucuronic Acid; D002482:Cellulose; D048271:Chitosan; C020254:cellulose sulfate
keywords: Membrane emulsification; Micron-sized microcapsules; Sodium alginate; Sodium cellulose sulfate; Water soluble chitosan