title: Differential role of afferent and efferent renal nerves in the maintenance of early- and late-phase Dahl S hypertension.
abstract: Clinical data suggest that renal denervation (RDNX) may be an effective treatment for human hypertension; however, it is unclear whether this therapeutic effect is due to ablation of afferent or efferent renal nerves. We have previously shown that RDNX lowers arterial pressure in hypertensive Dahl salt-sensitive (S) rats to a similar degree observed in clinical trials. In addition, we have recently developed a method for selective ablation of afferent renal nerves (renal-CAP). In the present study, we tested the hypothesis that the antihypertensive effect of RDNX in the Dahl S rat is due to ablation of afferent renal nerves by comparing the effect of complete RDNX to renal-CAP during two phases of hypertension in the Dahl S rat. In the early phase, rats underwent treatment after 3 wk of high-NaCl feeding when mean arterial pressure (MAP) was ∼ 140 mmHg. In the late phase, rats underwent treatment after 9 wk of high NaCl feeding, when MAP was ∼ 170 mmHg. RDNX reduced MAP ∼ 10 mmHg compared with sham surgery in both the early and late phase, whereas renal-CAP had no antihypertensive effect. These results suggest that, in the Dahl S rat, the antihypertensive effect of RDNX is not dependent on pretreatment arterial pressure, nor is it due to ablation of afferent renal nerves.
authors.affiliation: University of Minnesota, Department of Integrative Biology and Physiology, Minneapolis, Minnesota; and.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Foss
authors.affiliation: Michigan State University, Department of Pharmacology and Toxicology, East Lansing, Michigan.
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Fink
authors.affiliation: University of Minnesota, Department of Integrative Biology and Physiology, Minneapolis, Minnesota; and osbor003@umn.edu.
authors.forename: John W
authors.initials: JW
authors.lastname: Osborn
mesh_terms: D000344:Afferent Pathways / Q000503:physiopathology / Q000601:surgery; D000818:Animals; D062186:Arterial Pressure; D017763:Autonomic Denervation / Q000379:methods*; D004195:Disease Models, Animal; D004525:Efferent Pathways / Q000503:physiopathology / Q000601:surgery; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery*; D007668:Kidney / Q000294:innervation*; D008297:Male; D020303:Rats, Inbred Dahl; D017673:Sodium Chloride, Dietary; D013997:Time Factors
chemical_list: D017673:Sodium Chloride, Dietary
keywords: Dahl salt-sensitive rat; afferent renal nerves; efferent renal nerves; renal denervation