title: Severe Paradoxical Reaction During Treatment of Disseminated Tuberculosis in a Patient With Neutralizing Anti-IFNγ Autoantibodies.
abstract: Interferon-gamma (IFNγ) neutralizing autoantibodies are associated with disseminated nontuberculous mycobacterial infections. We report a previously healthy Thai woman with disseminated tuberculosis and high-titer IFNγ-neutralizing autoantibodies, who developed a severe inflammatory reaction during anti-tuberculosis treatment. IFNγ contributes to host control of tuberculosis but appears inessential for tuberculosis paradoxical reactions.
authors.affiliation: Laboratory of Clinical Infectious Diseases.
authors.forename: Yingda L
authors.initials: YL
authors.lastname: Xie
authors.affiliation: Laboratory of Clinical Infectious Diseases.
authors.forename: Lindsey B
authors.initials: LB
authors.lastname: Rosen
authors.affiliation: Laboratory of Immunoregulation.
authors.forename: Irini
authors.initials: I
authors.lastname: Sereti
authors.affiliation: Laboratory of Parasitic Diseases at the National Institute of Allergy and Infectious Diseases, National Institutes of Heath, Bethesda.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Barber
authors.affiliation: Laboratory of Clinical Infectious Diseases.
authors.forename: Ray Y
authors.initials: RY
authors.lastname: Chen
authors.affiliation: Laboratory of Immunoregulation.
authors.forename: Denise C
authors.initials: DC
authors.lastname: Hsu
authors.affiliation: Montgomery County Health Department, Silver Spring, Maryland.
authors.forename: S Sonia
authors.initials: SS
authors.lastname: Qasba
authors.affiliation: Laboratory of Clinical Infectious Diseases.
authors.forename: Christa S
authors.initials: CS
authors.lastname: Zerbe
authors.affiliation: Laboratory of Clinical Infectious Diseases.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Holland
authors.affiliation: Laboratory of Clinical Infectious Diseases.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Browne
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D057134:Antibodies, Neutralizing / Q000096:biosynthesis*; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007249:Inflammation / Q000276:immunology / Q000382:microbiology; D007371:Interferon-gamma / Q000097:blood / Q000276:immunology*; D008875:Middle Aged; D014391:Tuberculosis, Miliary / Q000188:drug therapy / Q000208:ethnology / Q000276:immunology*; D014481:United States
chemical_list: D000900:Anti-Bacterial Agents; D057134:Antibodies, Neutralizing; D001323:Autoantibodies; D007074:Immunoglobulin G; D007371:Interferon-gamma
keywords: IRIS; autoantibodies; disseminated tuberculosis; interferon-gamma; paradoxical reaction