title: Efficacy of acupuncture treatment for functional dyspepsia: A systematic review and meta-analysis.
abstract: OBJECTIVE
  The use of acupuncture treatment (AT) for functional dyspepsia is increasing, particularly in Asia. However, the efficacy of AT and its side effects have not been assessed. We performed a systematic review and meta-analysis of studies related to the effectiveness of AT for functional dyspepsia.
  
  
  METHODS
  This study is a systemic review and meta-analysis. Seven electronic databases, including those in the English and Chinese languages, were systematically searched for randomized controlled trials of AT for functional dyspepsia through November 2012. There were no language restrictions.
  
  
  METHODS
  Randomized controlled trials (RCT) AT compared with placebo control or a comparative intervention were considered. The methodological qualities of the studies were evaluated using the risk of bias (ROB). Subgroups were analyzed according to the kinds of controls.
  
  
  METHODS
  The primary outcomes were symptom scores. These included visual analogue scale (VAS) and Nepean Dyspepsia Index (NDI). Secondary outcomes were the total effective rate and adverse effects.
  
  
  RESULTS
  Twenty studies, including 1423 individual cases, were systematically reviewed. The risk of bias was high. Compared to sham AT, AT was associated with a significant positive effect in patients with functional dyspepsia (2.66, 95% CI 1.85-3.82). AT also improved symptoms for functional dyspepsia (1.18, 95% CI 1.01-2.60) compared to GI tract regulators on total effective rate. In addition, two articles produced a scale in favor of AT compared to medication (0.54, 95% CI 0.18-0.90). Two RCTs reported minimal AT-related adverse events.
  
  
  CONCLUSIONS
  The evidence suggests that AT is effective for functional dyspepsia. However, well-planned, long-term studies are necessary to evaluate the efficacy of AT for functional dyspepsia.
authors.affiliation: Department of Neuropsychiatry, College of Korean Medicine, Kyung-Hee University, Republic of Korea. Electronic address: kghana17@gmail.com.
authors.forename: Ka-Na
authors.initials: KN
authors.lastname: Kim
authors.affiliation: Department of Neuropsychiatry, College of Korean Medicine, Kyung-Hee University, Republic of Korea. Electronic address: lovepwr@khu.ac.kr.
authors.forename: Sun-Yong
authors.initials: SY
authors.lastname: Chung
authors.affiliation: Department of Neuropsychiatry, College of Korean Medicine, Kyung-Hee University, Republic of Korea. Electronic address: chosh@khu.ac.kr.
authors.forename: Seung-Hun
authors.initials: SH
authors.lastname: Cho
mesh_terms: D015670:Acupuncture Therapy; D000328:Adult; D004415:Dyspepsia / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: Acupuncture; Functional dyspepsia; Meta-analysis; Systematic review