title: Metallamacrocycle formation through dimerization of metal bioconjugates derived from amino acids and peptides.
abstract: Metallamacrocycles of 12, 16, and 22 members are obtained by deprotonation of the carboxylic group of the side chain of iminopyridine complexes derived from the amino acid β-alanine, and the peptides Gly-Gly and Gly-Gly-Gly. Instead of the expected intramolecular attack to give tridentate (N,N,O) ligands, the deprotonated carboxylate attacks in an inter-molecular manner to give dimers in which the ligand acts as a bridge bonded in a κ(2)(N,N') chelating fashion to one metal and as κ(O) to the other metal. The formation of the dimers is supported by NMR spectroscopy, mass spectrometry and X-ray crystallography.
authors.affiliation: GIR MIOMET-IU CINQUIMA/Química Inorgánica, Facultad de Ciencias Universidad de Valladolid, E-47005 Spain. dmsj@qi.uva.es.
authors.forename: Celedonio M
authors.initials: CM
authors.lastname: Álvarez
authors.affiliation: GIR MIOMET-IU CINQUIMA/Química Inorgánica, Facultad de Ciencias Universidad de Valladolid, E-47005 Spain. dmsj@qi.uva.es.
authors.forename: Raúl
authors.initials: R
authors.lastname: García-Rodríguez
authors.affiliation: GIR MIOMET-IU CINQUIMA/Química Inorgánica, Facultad de Ciencias Universidad de Valladolid, E-47005 Spain. dmsj@qi.uva.es.
authors.forename: Daniel
authors.initials: D
authors.lastname: Miguel
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D018360:Crystallography, X-Ray; D019281:Dimerization; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D019216:Metals, Heavy / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D047028:Macrocyclic Compounds; D019216:Metals, Heavy; D009942:Organometallic Compounds; D010455:Peptides; D011725:Pyridines