title: Association between serum uric acid levels and cerebral white matter lesions in Chinese individuals.
abstract: OBJECTIVE
  We aimed to evaluate the association between serum uric acid (SUA) levels and cerebral white matter lesions (WMLs) in Chinese individuals.
  
  
  METHODS
  We prospectively identified patients aged 50 years and older in neurology department from July 2014 to March 2015. Both periventricular WMLs (P-WMLs) and deep WMLs (D-WMLs) were identified on magnetic resonance imanging (MRI) scans and the severity was graded using the Fazekas method. Multivariate logistic regression analyses were performed to examine the association between SUA and WMLs.
  
  
  RESULTS
  A total of 480 eligible participants were enrolled in this study. SUA level in severe group was much higher than that in mild group (for P-WMLs: 320.21 ± 79.97 vs. 286.29 ± 70.18, p = 0.000; for D-WMLs: 314.71 ± 74.74 vs. 290.07 ± 74.04, p = 0.031). Subgroup analyses showed that higher SUA level was associated with higher severity of P-WMLs in women, but not in male patients. Multivariate logistic regression analyses showed that SUA was still associated with increased risk of higher severity of P-WMLs (OR = 1.003, 95% = 1.000-1.006), but not D-WMLs.
  
  
  CONCLUSIONS
  Elevated SUA level was independently associated with greater odds of higher severity of P-WMLs, particularly in women.
authors.affiliation: a Department of Neurology, Institute of Surgery Research, Daping Hospital , Third Military Medical University , Chongqing , PR China.
authors.forename: Meng-Jiao
authors.initials: MJ
authors.lastname: Sun
authors.affiliation: a Department of Neurology, Institute of Surgery Research, Daping Hospital , Third Military Medical University , Chongqing , PR China.
authors.forename: Bing-Hu
authors.initials: BH
authors.lastname: Li
authors.affiliation: a Department of Neurology, Institute of Surgery Research, Daping Hospital , Third Military Medical University , Chongqing , PR China.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Long
authors.affiliation: b The first retired cadres' clinic of Zibo military subarea , Zibo , PR China.
authors.forename: Yan-Qin
authors.initials: YQ
authors.lastname: Wang
authors.affiliation: a Department of Neurology, Institute of Surgery Research, Daping Hospital , Third Military Medical University , Chongqing , PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: a Department of Neurology, Institute of Surgery Research, Daping Hospital , Third Military Medical University , Chongqing , PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Department of Neurology, Institute of Surgery Research, Daping Hospital , Third Military Medical University , Chongqing , PR China.
authors.forename: Shao-Qiong
authors.initials: SQ
authors.lastname: Liao
authors.affiliation: a Department of Neurology, Institute of Surgery Research, Daping Hospital , Third Military Medical University , Chongqing , PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Pi
authors.affiliation: a Department of Neurology, Institute of Surgery Research, Daping Hospital , Third Military Medical University , Chongqing , PR China.
authors.forename: Lu
authors.initials: L
authors.lastname: Guo
authors.affiliation: a Department of Neurology, Institute of Surgery Research, Daping Hospital , Third Military Medical University , Chongqing , PR China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Zhang
authors.affiliation: a Department of Neurology, Institute of Surgery Research, Daping Hospital , Third Military Medical University , Chongqing , PR China.
authors.forename: Jing-Cheng
authors.initials: JC
authors.lastname: Li
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D044466:Asian People; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D056784:Leukoencephalopathies / Q000097:blood* / Q000000981:diagnostic imaging; D008077:Lipoproteins, LDL / Q000097:blood; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014527:Uric Acid / Q000097:blood*
chemical_list: D008077:Lipoproteins, LDL; D014527:Uric Acid; D002784:Cholesterol
keywords: cerebral small vessel disease; serum uric acid; white matter lesions