title: [Statin intolerance and associated muscular dysfunctions].
abstract: Hypercholesterolemia is a major risk factor for cardiovascular diseases. The 2012-2013 survey of Canada's public health measures revealed that dyslipidemia was present in 38% of the respondents aged between 18 and 79 years. According to the American College of Cardiology, the American Heart Association, the Canadian Cardiovascular Society and the Canadian Working Group Consensus, statins remain the treatment of choice for dyslipidemia and the reduction of cardiovascular risk. However, concerns and questions persist regarding statins use and safety, potential and harmful muscular side-effects, interactions with exercise, and molecular mechanisms of myotoxicity. The goal of the present review is to provide a clear picture of the clinical situation and to investigate possible mechanisms of statin-induced myopathy. A better understanding of muscle pathology in statin users is absolutely essential to minimize their muscle symptoms and to provide a sound clinical basis for the management of cardiovascular risk.
authors.affiliation: Centre de recherche du CHU de Québec-CHUL, université Laval, 2705, boulevard Laurier, Québec, QC, G1V 4G2 Canada.
authors.forename: Antoine
authors.initials: A
authors.lastname: Boulanger-Piette
authors.affiliation: Centre de recherche du CHU de Québec-CHUL, université Laval, 2705, boulevard Laurier, Québec, QC, G1V 4G2 Canada.
authors.forename: Jean
authors.initials: J
authors.lastname: Bergeron
authors.affiliation: Faculté de médecine, département de réadaptation, université Laval, 1050, avenue de la Médecine, Québec, QC, G1V 0A6 Canada.
authors.forename: Joël
authors.initials: J
authors.lastname: Desgreniers
authors.affiliation: Faculté de médecine, département de réadaptation, université Laval, 1050, avenue de la Médecine, Québec, QC, G1V 0A6 Canada.
authors.forename: Michèle
authors.initials: M
authors.lastname: Côté-Levesque
authors.affiliation: Faculté de médecine, département de réadaptation, université Laval, 1050, avenue de la Médecine, Québec, QC, G1V 0A6 Canada.
authors.forename: Dominic
authors.initials: D
authors.lastname: Brassard
authors.affiliation: Pavillon éducation physique et sports, université Laval, 2300, rue de la Terrasse, Québec, QC, G1V 0A6, Canada.
authors.forename: Denis R
authors.initials: DR
authors.lastname: Joanisse
authors.affiliation: Centre de recherche du CHU de Québec-CHUL, université Laval, 2705, boulevard Laurier, Québec, QC, G1V 4G2 Canada.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Frenette
mesh_terms: D000465:Algorithms; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000188:drug therapy; D009135:Muscular Diseases / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors