title: Role of redoximiRs in fibrogenesis.
abstract: Fibrosis can be defined as an excessive accumulation of extracellular matrix (ECM) components, ultimately leading to stiffness, scarring and devitalized tissue. MicroRNAs (miRNAs) are short, 19-25 nucleotides (nt), non-coding RNAs involved in the post-transcriptional regulation of gene expression. Recently, miRNAs have also emerged as powerful regulators of fibrotic processes and have been termed "fibromiRs". Oxidative stress represents a self-perpetuating mechanism in fibrogenesis. MiRNAs can also influence the expression of genes responsible for the generation of reactive oxygen species (ROS) and antioxidant defence and are termed "redoximiRs". Here, we review the current knowledge of mechanisms by which "redoximiRs" regulate fibrogenesis. This new set of miRNAs may be called "redoxifibromiRs".
authors.affiliation: Department of Cell Biology and Immunology, Centro de Biología Molecular "Severo Ochoa" (CBMSO), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Nicolás Cabrera 1, 28049 Madrid, Spain. Electronic address: mfierro@cbm.csic.es.
authors.forename: Marta
authors.initials: M
authors.lastname: Fierro-Fernández
authors.affiliation: Department of Cell Biology and Immunology, Centro de Biología Molecular "Severo Ochoa" (CBMSO), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Nicolás Cabrera 1, 28049 Madrid, Spain.
authors.forename: Verónica
authors.initials: V
authors.lastname: Miguel
authors.affiliation: Department of Cell Biology and Immunology, Centro de Biología Molecular "Severo Ochoa" (CBMSO), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Nicolás Cabrera 1, 28049 Madrid, Spain. Electronic address: slamas@cbm.csic.es.
authors.forename: Santiago
authors.initials: S
authors.lastname: Lamas
mesh_terms: D005355:Fibrosis; D005786:Gene Expression Regulation; D006331:Heart Diseases / Q000235:genetics*; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics*; D008103:Liver Cirrhosis / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D018384:Oxidative Stress; D011658:Pulmonary Fibrosis / Q000235:genetics*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D012871:Skin Diseases / Q000235:genetics*
chemical_list: D035683:MicroRNAs; D017382:Reactive Oxygen Species
keywords: Fibrosis; MicroRNAs; Oxidative stress