title: Effect of sound on gap-junction-based intercellular signaling: Calcium waves under acoustic irradiation.
abstract: We present a previously unrecognized effect of sound waves on gap-junction-based intercellular signaling such as in biological tissues composed of endothelial cells. We suggest that sound irradiation may, through temporal and spatial modulation of cell-to-cell conductance, create intercellular calcium waves with unidirectional signal propagation associated with nonconventional topologies. Nonreciprocity in calcium wave propagation induced by sound wave irradiation is demonstrated in the case of a linear and a nonlinear reaction-diffusion model. This demonstration should be applicable to other types of gap-junction-based intercellular signals, and it is thought that it should be of help in interpreting a broad range of biological phenomena associated with the beneficial therapeutic effects of sound irradiation and possibly the harmful effects of sound waves on health.
authors.affiliation: Department of Materials Science and Engineering, University of Arizona, Tucson, Arizona 85721, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Deymier
authors.affiliation: Department of Materials Science and Engineering, University of Arizona, Tucson, Arizona 85721, USA.
authors.forename: N
authors.initials: N
authors.lastname: Swinteck
authors.affiliation: Department of Materials Science and Engineering, University of Arizona, Tucson, Arizona 85721, USA.
authors.forename: K
authors.initials: K
authors.lastname: Runge
authors.affiliation: Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, Missouri 63110, USA.
authors.forename: A
authors.initials: A
authors.lastname: Deymier-Black
authors.affiliation: Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky 40202, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Hoying
mesh_terms: D000162:Acoustics; D020013:Calcium Signaling; D004058:Diffusion; D017629:Gap Junctions / Q000378:metabolism*; D008954:Models, Biological; D013016:Sound; D062211:Spatio-Temporal Analysis