title: Dynorphin, Dysphoria, and Dependence: the Stress of Addiction.
authors.affiliation: Department of Pharmacology, University of Washington, Seattle, WA, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Chavkin
authors.affiliation: National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA.
authors.forename: George F
authors.initials: GF
authors.lastname: Koob
mesh_terms: D000818:Animals; D016739:Behavior, Addictive / Q000378:metabolism* / Q000523:psychology / Q000628:therapy; D001549:Benzamides / Q000494:pharmacology / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000378:metabolism* / Q000523:psychology / Q000628:therapy; D004399:Dynorphins / Q000378:metabolism*; D006801:Humans; D011759:Pyrrolidines / Q000494:pharmacology / Q000627:therapeutic use; D017473:Receptors, Opioid, kappa / Q000037:antagonists & inhibitors / Q000378:metabolism; D013315:Stress, Psychological / Q000378:metabolism* / Q000523:psychology / Q000628:therapy
chemical_list: D001549:Benzamides; D011759:Pyrrolidines; D017473:Receptors, Opioid, kappa; D004399:Dynorphins; C000590915:Aticaprant