title: Functional Genetic Variants of PPARx03B3; and PPARα Encoding Peroxisome Proliferator-Activated Receptors and Susceptibility to Ischemic Stroke in Chinese Han Population.
abstract: BACKGROUND
  PPARx03B3; and PPARα belong to a receptor family of ligand-activated transcription factors involved in the regulation of inflammation, cellular glucose uptake, protection against atherosclerosis and endothelial cell function. Through these effects, they might be involved with the ischemic stroke (IS).
  
  
  METHODS
  One thousand two hundred ninety-six subjects from the Chinese Han Population were chosen to assess the nature of the functional polymorphisms of PPARs and any links with IS. Multivariate logistic regression analysis was used to examine the association between PPARx03B3; and PPARα genotypes and a diagnosis of IS.
  
  
  RESULTS
  Pro/Ala carriage may be associated with the decreased risk of IS in Hans (OR 0.542, 95% CI 0.346-0.850). The 162Val allele frequency at the DNA-binding region of PPARα was extremely rare in Chinese Han population.
  
  
  CONCLUSIONS
  PPARx03B3; 12Pro/Ala resulting in an amino acid exchange in N-terminal sequence may be an independent protective factor for IS in the Chinese Han population. However, more populations are warranted to validate our findings.
authors.affiliation: Hubei Center for Disease Control and Prevention, Wuhan, PR China.
authors.forename: Yeqing
authors.initials: Y
authors.lastname: Tong
authors.forename: Li
authors.initials: L
authors.lastname: Cai
authors.forename: ShengHong
authors.initials: S
authors.lastname: Han
authors.forename: Qing
authors.initials: Q
authors.lastname: Lu
authors.forename: Xuhua
authors.initials: X
authors.lastname: Guan
authors.forename: Xiaoxv
authors.initials: X
authors.lastname: Ying
authors.forename: Shuangyi
authors.initials: S
authors.lastname: Hou
authors.forename: Fanxian
authors.initials: F
authors.lastname: Zhan
authors.forename: Jin-quan
authors.initials: JQ
authors.lastname: Cheng
authors.forename: Jiafa
authors.initials: J
authors.lastname: Liu
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D047493:PPAR alpha / Q000235:genetics*; D047495:PPAR gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D065840:Protective Factors; D020521:Stroke / Q000235:genetics*
chemical_list: D047493:PPAR alpha; D047495:PPAR gamma