title: [Protective Effect of Saussurea involucrata Alcohol Extract on Liver Mitochondria in Mice Under Hypoxia Condition].
abstract: OBJECTIVE
  To study the protective effect of Saussurea involucrata alcohol extract on liver mitochondria in mice under hypoxia condition.
  
  
  METHODS
  The hypoxia mice model was established, the BALB/c mice were randomly divided into four groups:normal group ,hypoxia model group, positive control group and Saussurea involucrata alcohol extract group. Mice were put into low pressure oxygen chamber and decompressed, adapted to hypobaric hypoxia environment of simulated altitude of 8,000 m for 12 h, and then recovered to normal altitude. The mice were sacrificed and the liver mitochondria was isolated, the mitochondrial membrane potential and the activity of malate dehydrogenase, aconitase, α-ketoglutarate dehydrogenase, pyruvate dehydrogenase and mitochondrial complex I, II and V were measured.
  
  
  RESULTS
  Compared with hypoxia model group, Saussurea involucrata alcohol extract protected mitochondrial membrane potential, sustained the activities of aconitase, α-ketoglutarate dehydrogenase, pyruvate dehydrogenase, and mitochondrial complex I, II and V under hypoxia condition.
  
  
  CONCLUSIONS
  Saussurea involucrata alcohol extract can protect the liver mitochondrial function in mice under hypoxia condtion.
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.forename: Peng-cheng
authors.initials: PC
authors.lastname: Fan
authors.forename: Lei
authors.initials: L
authors.lastname: He
authors.forename: Jin-hua
authors.initials: JH
authors.lastname: Wu
authors.forename: Hui-ping
authors.initials: HP
authors.lastname: Ma
authors.forename: Lin-lin
authors.initials: LL
authors.lastname: Jing
authors.forename: Zheng-ping
authors.initials: ZP
authors.lastname: Jia
mesh_terms: D000531:Altitude; D000818:Animals; D003664:Decompression; D004195:Disease Models, Animal; D000431:Ethanol; D000860:Hypoxia / Q000188:drug therapy*; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008930:Mitochondria, Liver / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D030441:Saussurea / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D000431:Ethanol