title: Long-term wheel-running and acute 6-h advances alter glucose tolerance and insulin levels in TALLYHO/JngJ mice.
abstract: Studies have shown a relationship between circadian rhythm disruptions and type-2 diabetes. This investigation examined the effects of circadian disruption (6-h phase advances) on the progression of diabetes in a type-2 diabetic mouse model -TALLYHO/JngJ - and whether wheel-running can alleviate the effects of the phase advances. 6-h advances alter fasting glucose, glucose tolerance and insulin production. Wheel-running reduced body mass, improved glucose tolerance and reduced insulin in TALLYHO/JngJ and alleviated some of the changes in diabetic symptoms due to 6-h advances. These results indicate that individuals with type-2 diabetes can benefit from physical activity and exercise can be a countermeasure to offset the effects of an acute phase advance.
authors.affiliation: a Department of Biological Sciences , Bridgewater State University , Bridgewater , MA , USA.
authors.forename: Nara F
authors.initials: NF
authors.lastname: Nascimento
authors.affiliation: a Department of Biological Sciences , Bridgewater State University , Bridgewater , MA , USA.
authors.forename: Jasmin A
authors.initials: JA
authors.lastname: Hicks
authors.affiliation: a Department of Biological Sciences , Bridgewater State University , Bridgewater , MA , USA.
authors.forename: Karen N
authors.initials: KN
authors.lastname: Carlson
authors.affiliation: a Department of Biological Sciences , Bridgewater State University , Bridgewater , MA , USA.
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Hatzidis
authors.affiliation: a Department of Biological Sciences , Bridgewater State University , Bridgewater , MA , USA.
authors.forename: Danielle N
authors.initials: DN
authors.lastname: Amaral
authors.affiliation: b Department of Psychiatry , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.
authors.forename: Ryan W
authors.initials: RW
authors.lastname: Logan
authors.affiliation: a Department of Biological Sciences , Bridgewater State University , Bridgewater , MA , USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Seggio
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002940:Circadian Rhythm / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004195:Disease Models, Animal; D005215:Fasting / Q000502:physiology*; D007328:Insulin / Q000096:biosynthesis*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D010805:Physical Conditioning, Animal; D012420:Running / Q000502:physiology*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: Advance; TALLYHO/JngJ; jet-lag; mouse; shift-work; type-2 diabetes