title: Pediatric asthma and autism-genomic perspectives.
abstract: High-throughput technologies, ranging from microarrays to NexGen sequencing of RNA and genomic DNA, have opened new avenues for exploration of the pathobiology of human disease. Comparisons of the architecture of the genome, identification of mutated or modified sequences, and pre-and post- transcriptional regulation of gene expression as disease specific biomarkers are revolutionizing our understanding of the causes of disease and are guiding the development of new therapies. There is enormous heterogeneity in types of genomic variation that occur in human disease. Some are inherited, while others are the result of new somatic or germline mutations or errors in chromosomal replication. In this review, we provide examples of changes that occur in the human genome in two of the most common chronic pediatric disorders, autism and asthma. The incidence and economic burden of both of these disorders are increasing worldwide. Genomic variations have the potential to serve as biomarkers for personalization of therapy and prediction of outcomes.
authors.affiliation: Department of Computer Science and Statistics, Jeju National University, Jeju Ciy, Jeju Do, South Korea. sshshoh1105@gmail.com.
authors.forename: Sunghee
authors.initials: S
authors.lastname: Oh
authors.affiliation: Division of Asthma Research, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA. hong.ji@cchmc.org.
authors.forename: Hong
authors.initials: H
authors.lastname: Ji
authors.affiliation: Division of Psychiatry, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA. Drew.Barzman@cchmc.org.
authors.forename: Drew
authors.initials: D
authors.lastname: Barzman
authors.affiliation: Division of Biostatistics and Epidemiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. ping-i.lin@cchmc.org.
authors.forename: Ping-I
authors.initials: PI
authors.lastname: Lin
authors.affiliation: Division of Biomedical Informatics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA. john.hutton@cchmc.org.
authors.forename: John
authors.initials: J
authors.lastname: Hutton
keywords: Asthma; Autism; Genomic variation; Pathobiology; Pediatric disorders; Transcription