title: A case of tumor-like inflammatory demyelinating disease with progressive brain and spinal cord involvement.
abstract: BACKGROUND
  Tumor-like inflammatory demyelinating disease (TIDD) usually occurs in the brain and rarely occurs in the spinal cord. TIDD appears to be very similar to tumors such as gliomas on imaging, which may lead to incorrect or delayed diagnosis and treatment.
  
  
  METHODS
  Because of headache and incoherent speech, a 24-year-old Chinese male presented to our hospital with a two-week history of respiratory infections. After dexamethasone treatment, his symptoms still got worse and surgery was performed for diagnostic purposes. Histological examination revealed that the lesion was inflammatory. Further lesions appeared in the spine (T3 and T4 levels) after two months and in the right occipital lobe after three months. After intravenous immunoglobulin (IVIG) and methylprednisolone treatment, his symptoms improved.
  
  
  CONCLUSIONS
  Progressive lesions may damage the brain and spinal cord, and long-term prednisolone and IVIG therapy are beneficial in TIDD patients.
authors.affiliation: Department of Neurology, Wuhan General Hospital of Guangzhou Command, Wuhan, China.
authors.forename: Xu Zhi
authors.initials: XZ
authors.lastname: Peng
authors.affiliation: Department of Neurology, Wuhan General Hospital of Guangzhou Command, Wuhan, China.
authors.forename: Li Hong
authors.initials: LH
authors.lastname: Hua
authors.affiliation: Department of Radiology, Wuhan General Hospital of Guangzhou Command, Wuhan, China.
authors.forename: Sun Zhi
authors.initials: SZ
authors.lastname: Qiang
authors.affiliation: Department of Neurology, Wuhan General Hospital of Guangzhou Command, Wuhan, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Qiang
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D003711:Demyelinating Diseases / Q000473:pathology* / Q000628:therapy; D003937:Diagnosis, Differential; D004660:Encephalitis / Q000473:pathology* / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009187:Myelitis / Q000473:pathology* / Q000628:therapy; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D008775:Methylprednisolone