title: [Cardiotoxicity study of Shenfu compatibility in rats based on metabonomics].
abstract: To research the effect of Ginseng Radix et Rhizoma and Aconiti Lateralis Radix Praeparata compatibility on cardiac toxicity in rats by UPLC-Q-TOF/MS, and explore the endogenous markers and molecule mechanism. Different compatibility of Shenfu decoction were given to male Wistar rats at dosage of 20 g · kg(-1) for 7 days, collected the serum, and analyze the endogenous metabolites effected by Shenfu formulation by principal component analysis and partial least-squares analysis. Results showed that content of glutathione, phosphatidylcholine and citric acid decreased in mixed-decoction group, while ascorbic acid, uric acid, D-galactose, tryptophan, L-phenylalanine increased. The results showed cardiac toxicity of Aconiti Lateralis Radix Praeparata in Shenfu mixed-decoction. Shenfu co-decoction group showed a similar or weaker trend compared with control group, but most of them do not have a statistically significant. The results indicated the scientific basis of Shenfu compatibility by comparison of co-decoction group with mixed-decoction group. Shenfu compatibility can reduce cardiac toxicity induced by Aconiti Lateralis Radix Praeparata, and citric acid, glutathione, phosphatidyl choline, uric acid might be regarded as potential markers of cardiotoxicity.
authors.forename: Jia-le
authors.initials: JL
authors.lastname: He
authors.forename: Jia-wei
authors.initials: JW
authors.lastname: Zhao
authors.forename: Zeng-chun
authors.initials: ZC
authors.lastname: Ma
authors.forename: Qian-de
authors.initials: QD
authors.lastname: Liang
authors.forename: Yu-guang
authors.initials: YG
authors.lastname: Wang
authors.forename: Hong-ling
authors.initials: HL
authors.lastname: Tan
authors.forename: Cheng-rong
authors.initials: CR
authors.lastname: Xiao
authors.lastname: Tang Xiang-lin
authors.forename: Yue
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000818:Animals; D015415:Biomarkers; D066126:Cardiotoxicity; D004365:Drugs, Chinese Herbal / Q000633:toxicity*; D005978:Glutathione / Q000097:blood; D016018:Least-Squares Analysis; D008297:Male; D055432:Metabolomics / Q000379:methods*; D025341:Principal Component Analysis; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015415:Biomarkers; D004365:Drugs, Chinese Herbal; C492793:Shen-Fu; D005978:Glutathione