title: Distribution of Enteroinvasive and Enterotoxigenic Escherichia coli Across Space and Time in Northwestern Ecuador.
abstract: Although Escherichia coli infections are common throughout the developing world, their prevalence patterns in space and over time are not well characterized. We used serial case control data collected from 16 communities in northwestern Ecuador between 2004 and 2010, to examine the prevalence of enteroinvasive E. coli (EIEC) and enterotoxigenic E. coli (ETEC). At its peak, the regional prevalence of EIEC was 8.3 infections/100 persons but this decreased to 1 infection/1,000 persons. The regional prevalence of ETEC ranged from 8 infections/1,000 persons to 3.7 infections/100 persons. The prevalence pattern of EIEC resembled that of a large epidemic whereas the prevalence of ETEC was more stable over time. Here, we provide community-based evidence for temporal shifts in the dominant E. coli pathotype from EIEC to ETEC over a multi-year time period. Furthermore, genotype analysis suggests that a given strain of EIEC and ETEC can persist in this region for long periods, up to 24 and 55 months, respectively.
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador dbhavnani@clintonhealthaccess.org.
authors.forename: Darlene
authors.initials: D
authors.lastname: Bhavnani
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
authors.forename: Rosa de los Ángeles
authors.initials: Rde L
authors.lastname: Bayas
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
authors.forename: Velma K
authors.initials: VK
authors.lastname: Lopez
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
authors.forename: Lixin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Trueba
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
authors.forename: Betsy
authors.initials: B
authors.lastname: Foxman
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
authors.forename: Carl
authors.initials: C
authors.lastname: Marrs
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
authors.forename: William
authors.initials: W
authors.lastname: Cevallos
authors.affiliation: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan; Microbiology Institute, Universidad San Francisco de Quito, Quito, Ecuador; Centro de Biomedicina, Universidad Central del Ecuador, Quito, Ecuador.
authors.forename: Joseph N S
authors.initials: JN
authors.lastname: Eisenberg
mesh_terms: D016022:Case-Control Studies; D004484:Ecuador / Q000453:epidemiology; D054307:Enterotoxigenic Escherichia coli / Q000145:classification / Q000235:genetics; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology*; D005838:Genotype; D006801:Humans; D015995:Prevalence; D013997:Time Factors