title: Activity of Eravacycline against Escherichia coli Clinical Isolates Collected from U.S. Veterans in 2011 in Relation to Coresistance Phenotype and Sequence Type 131 Genotype.
abstract: Eravacycline is a novel broad-spectrum fluorocycline with potent Gram-negative activity, including for multidrug-resistant strains. Among 472 Escherichia coli clinical isolates from 24 Veterans Affairs medical centers (in 2011), divided equally as susceptible versus resistant to fluoroquinolones, broth microdilution eravacycline MICs were distributed unimodally, ranging from 0.03 to 1.0 μg/ml (MIC50 of 0.125 μg/ml, MIC90 of 0.25 μg/ml). Eravacycline MICs were ∼ 2-fold higher among fluoroquinolone-resistant, gentamicin-resistant, multidrug-resistant, and sequence type 131 (ST131) isolates (P < 0.01 for each comparison).
authors.affiliation: VA Medical Center, Minneapolis, Minnesota, USA University of Minnesota, Minneapolis, Minnesota, USA johns007@umn.edu.
authors.forename: James R
authors.initials: JR
authors.lastname: Johnson
authors.affiliation: University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Porter
authors.affiliation: VA Medical Center, Minneapolis, Minnesota, USA University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Johnston
authors.affiliation: VA Medical Center, Minneapolis, Minnesota, USA University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Thuras
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D013754:Tetracyclines / Q000494:pharmacology*; D014481:United States; D014728:Veterans
chemical_list: D000900:Anti-Bacterial Agents; D013754:Tetracyclines; C571179:eravacycline