title: [CALCIFYING NANOPARTICLES IN PATHOMORPHOGENESIS OF STRUCTURAL LESIONS OF HEART VALVES].
abstract: Over the last 10 years, calcifying nanoparticles (CNP) have attracted attention as structures detected. together with many other nanostructures in biopsies from patients operated for the correction of aortic valve malformations. The results of the present work performed with the use of high-resolution transmission and scanning electron microscopes agree on the whole with the data of other authors. Some new findings include CNP adhesion to collagen fibers and specifically-shaped, shallow invaginations or craters at their surface. The possible pathophysiological mechanisms that promote involvement of CNP in the development of the disease are considered.
authors.forename: N I
authors.initials: NI
authors.lastname: Gulyaev
authors.forename: A E
authors.initials: AE
authors.lastname: Korovin
authors.forename: A S
authors.initials: AS
authors.lastname: Kusay
authors.forename: A I
authors.initials: AI
authors.lastname: Nevorotin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000378:metabolism / Q000601:surgery / Q000648:ultrastructure*; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D059587:Calcifying Nanoparticles / Q000378:metabolism*; D002114:Calcinosis / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D003094:Collagen / Q000737:chemistry*; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged
chemical_list: D059587:Calcifying Nanoparticles; D003094:Collagen