title: Comparative Analysis of Tunical Plication vs. Intralesional Injection Therapy for Ventral Peyronie's Disease.
abstract: BACKGROUND
  Approximately 10% of Peyronie's disease (PD) patients present with ventral curvatures and, as such, there is a paucity of data describing the optimal approach for treatment.
  
  
  OBJECTIVE
  This study aims to compare the outcomes of surgery (tunical plication [TP]) and intralesional injection (ILI) therapy (interferon-α2b) in men with ventral PD.
  
  
  METHODS
  Retrospective data were collected from two centers: Tulane University (ILI) and Technical University of Munich (TP). Collected variables included patient demographics, pre- and post-treatment sexual function, rigorous penile measurements (curvature, length, and penile vascular findings), and post-treatment outcomes.
  
  
  RESULTS
  A total of 35 patients with ventral PD (21 ILI and 14 TP) were included in the study. There were no significant differences between the two groups prior to the interventions. There was a significantly better improvement in mean curvature with TP (46.4 degrees) as compared with ILI (9.3), P < 0.0001. TP was also associated with a significantly higher rate of ≥20% improvement in curvature as compared with ILI (100% vs. 67%, P = 0.027). Although there was no significant difference in post-treatment change in Sexual Health Inventory for Men (SHIM) scores between the groups, 36% of the ILI patients noted an improved SHIM score as compared with none in the TP group. Erect penile length was preserved or improved in 67% of the ILI group vs. 14% of the TP group, P = 0.005.
  
  
  CONCLUSIONS
  TP confers a better overall improvement in penile curvature as compared with ILI in patients with ventral PD. Preserved or improved erect penile length and SHIM scores may be observed in patients undergoing ILI. 12:2492-2498.
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
authors.forename: Faysal A
authors.initials: FA
authors.lastname: Yafi
authors.affiliation: Department of Urology, Technical University of Munich, Munich, Germany.
authors.forename: Georgios
authors.initials: G
authors.lastname: Hatzichristodoulou
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Knoedler
authors.affiliation: Department of Urology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Landon W
authors.initials: LW
authors.lastname: Trost
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
authors.forename: Suresh C
authors.initials: SC
authors.lastname: Sikka
authors.affiliation: Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
authors.forename: Wayne J G
authors.initials: WJ
authors.lastname: Hellstrom
mesh_terms: D000328:Adult; D006801:Humans; D015552:Injections, Intralesional; D016898:Interferon-alpha / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010411:Penile Induration / Q000503:physiopathology / Q000628:therapy*; D010413:Penis / Q000503:physiopathology* / Q000601:surgery; D011994:Recombinant Proteins / Q000008:administration & dosage*; D012189:Retrospective Studies; D013536:Suture Techniques; D016896:Treatment Outcome
chemical_list: D016898:Interferon-alpha; D011994:Recombinant Proteins
keywords: Interferon α2b; Intralesional Injection; Peyronie's Disease; Tunical Plication; Ventral Curvature; Ventral Plaque