title: [Neurologic manifestations of sarcoidosis: A study of 18 cases].
abstract: BACKGROUND
  Sarcoidosis is a multisystemic granulomatous disease of unknown aetiology. Neurologic manifestations are found in 5 to 10% of cases.
  
  
  METHODS
  We conducted a retrospective study over 6-year period including 18 patients diagnosed with neurosarcoidosis in the Neurologic department of the Military Hospital of Instruction of Tunis. Clinical, radiological, therapeutic features and outcome were studied.
  
  
  RESULTS
  The mean age was 43.44 years. Neurologic signs were the first symptom in 10 cases. Peripheral nervous system impairment was often found. Meningitis was noted in 8 cases. Biological tests are not contributive for the diagnosis. The brain magnetic resonance imaging was pathologic in 10 cases. Corticosteroids were administrated in the majority of cases. Eight patients did not show any sign of improvement. Ten cases improved with treatment.
  
  
  CONCLUSIONS
  Diagnosis of neurosarcoidosis is difficult because of its clinical and radiological polymorphism. It is based on a clinical history suggestive of neurosarcoidosis, laboratory, imaging and histological studies.
authors.affiliation: Service de neurologie, hôpital militaire principal d'instruction de Tunis, Mont Fleury, 1008 Tunis, Tunisie. Electronic address: nahla.touati@hotmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Touati
authors.affiliation: Service de neurologie, hôpital militaire principal d'instruction de Tunis, Mont Fleury, 1008 Tunis, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Mansour
authors.affiliation: Service de neurologie, hôpital militaire principal d'instruction de Tunis, Mont Fleury, 1008 Tunis, Tunisie.
authors.forename: I
authors.initials: I
authors.lastname: Bedoui
authors.affiliation: Service de médecine, hôpital régional de Jendouba, avenue de l'UMA 8100, Jendouba, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Kacem
authors.affiliation: Service de neurologie, hôpital militaire principal d'instruction de Tunis, Mont Fleury, 1008 Tunis, Tunisie.
authors.forename: H
authors.initials: H
authors.lastname: Derbali
authors.affiliation: Service de neurologie, hôpital militaire principal d'instruction de Tunis, Mont Fleury, 1008 Tunis, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Riahi
authors.affiliation: Service de neurologie, hôpital militaire principal d'instruction de Tunis, Mont Fleury, 1008 Tunis, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Messelmani
authors.affiliation: Service de neurologie, hôpital militaire principal d'instruction de Tunis, Mont Fleury, 1008 Tunis, Tunisie.
authors.forename: J
authors.initials: J
authors.lastname: Zaouali
authors.affiliation: Service d'hématologie, hôpital militaire principal d'instruction de Tunis, Mont Fleury, 1008 Tunis, Tunisie.
authors.forename: N
authors.initials: N
authors.lastname: Fekih-Mrissa
authors.affiliation: Service de neurologie, hôpital militaire principal d'instruction de Tunis, Mont Fleury, 1008 Tunis, Tunisie.
authors.forename: R
authors.initials: R
authors.lastname: Mrissa
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D017668:Age of Onset; D001921:Brain / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002493:Central Nervous System Diseases / Q000150:complications / Q000473:pathology* / Q000523:psychology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000473:pathology; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000150:complications / Q000473:pathology* / Q000523:psychology*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Diagnosis; Diagnostic; Neurosarcoidosis; Neurosarcoïdose; Sarcoidosis; Sarcoïdose; Traitement; Treatment