title: Nanofibers for drug delivery - incorporation and release of model molecules, influence of molecular weight and polymer structure.
abstract: Nanofibers were prepared from polycaprolactone, polylactide and polyvinyl alcohol using Nanospider(TM) technology. Polyethylene glycols with molecular weights of 2 000, 6 000, 10 000 and 20 000 g/mol, which can be used to moderate the release profile of incorporated pharmacologically active compounds, served as model molecules. They were terminated by aromatic isocyanate and incorporated into the nanofibers. The release of these molecules into an aqueous environment was investigated. The influences of the molecular length and chemical composition of the nanofibers on the release rate and the amount of released polyethylene glycols were evaluated. Longer molecules released faster, as evidenced by a significantly higher amount of released molecules after 72 hours. However, the influence of the chemical composition of nanofibers was even more distinct - the highest amount of polyethylene glycol molecules released from polyvinyl alcohol nanofibers, the lowest amount from polylactide nanofibers.
authors.affiliation: The Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic.
authors.forename: Jakub
authors.initials: J
authors.lastname: Hrib
authors.affiliation: The Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic.
authors.forename: Jakub
authors.initials: J
authors.lastname: Sirc
authors.affiliation: The Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic.
authors.forename: Radka
authors.initials: R
authors.lastname: Hobzova
authors.affiliation: Department of Analytical Chemistry, Faculty of Science, Charles University in Prague, Albertov 2030, 128 43 Prague 2, Czech Republic.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Hampejsova
authors.affiliation: Department of Analytical Chemistry, Faculty of Science, Charles University in Prague, Albertov 2030, 128 43 Prague 2, Czech Republic.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Bosakova
authors.affiliation: Nanovia Ltd., Podkrusnohorska 271, 436 03 Litvinov-Chuderin, Czech Republic.
authors.forename: Marcela
authors.initials: M
authors.lastname: Munzarova
authors.affiliation: The Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic.
authors.forename: Jiri
authors.initials: J
authors.lastname: Michalek
keywords: nanofibers; nanofibrous carriers; needle-free electrospinning; release kinetics