title: A short review on structure and role of cyclic-3',5'-adenosine monophosphate-specific phosphodiesterase 4 as a treatment tool.
abstract: Cyclic nucleotide phosphodiesterases (PDEs) are known as a super-family of enzymes which catalyze the metabolism of the intracellular cyclic nucleotides, cyclic-3',5'-adenosine monophosphate (cAMP), and cyclic-3',5'-guanosine monophosphate that are expressed in a variety of cell types that can exert various functions based on their cells distribution. The PDE4 family has been the focus of vast research efforts over recent years because this family is considered as a prime target for therapeutic intervention in a number of inflammatory diseases such as asthma, chronic obstructive pulmonary disease, and rheumatoid arthritis, and it should be used and researched by pharmacists. This is because the major isoform of PDE that regulates inflammatory cell activity is the cAMP-specific PDE, PDE4. This review discusses the relationship between PDE4 and its inhibitor drugs based on structures, cells distribution, and pharmacological properties of PDE4 which can be informative for all pharmacy specialists.
authors.affiliation: Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran ; Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Nahid
authors.initials: N
authors.lastname: Eskandari
authors.affiliation: Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Omid
authors.initials: O
authors.lastname: Mirmosayyeb
authors.affiliation: Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Gazaleh
authors.initials: G
authors.lastname: Bordbari
authors.affiliation: Department of Human Vaccines, Razi Serum and Vaccine Research Institute, Karaj, Alborz, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Bastan
authors.affiliation: Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Yousefi
authors.affiliation: Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Andalib
keywords: Cyclic-3’, 5’-adenosine monophosphate; inhibitors; phosphodiesterase; phosphodiesterase 4