title: Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo.
abstract: The depletion of stem cell pools and the accumulation of senescent cells in animal tissues are linked to aging. Planarians are invertebrate flatworms and are unusual in that their stem cells, called neoblasts, are constantly replacing old and dying cells. By eliminating neoblasts in worms via irradiation, the biological principles of aging are exposed in the absence of wound healing and regeneration, making planaria a powerful tool for aging research.
authors.affiliation: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland; pperrigue@ibch.poznan.pl.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Perrigue
authors.affiliation: Department of Immunology and Biotechnology, University of Pécs, Pécs, Hungary.
authors.forename: Joseph
authors.initials: J
authors.lastname: Najbauer
authors.affiliation: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
authors.forename: Agnieszka A
authors.initials: AA
authors.lastname: Jozwiak
authors.affiliation: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Barciszewski
authors.affiliation: Department of Neurosciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA.|Division of Neurosurgery, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA.
authors.forename: Karen S
authors.initials: KS
authors.lastname: Aboody
authors.affiliation: Department of Neurosciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Barish
keywords: aging; cellular senescence; epigenetics; histone H3K27; invertebrate; planarian; stem cells