title: IMBALANCES IN PROTEIN METABOLISM IN CRITICAL CARE PATIENT WITH SYSTEMIC INFLAMMATORY RESPONSE SYNDROME AT ADMISSION IN INTENSIVE CARE UNIT.
abstract: BACKGROUND
  trauma and severe infections cause remarkable metabolic changes in patient with SIRS from an adaptive response aimed to control the underlying disease, repairing damaged tissue, and to synthesize substrates. If the attack is intense and sustained and the patient has a compromised nutritional status, can evolve into multiple organ failure and death.
  
  
  OBJECTIVE
  assessment of nutritional proteic status and the involvement of proteins and inflammatory factors in critically ill patients.
  
  
  METHODS
  multicenter observational analytical study in critical ill patients at the admission in ICU.
  
  
  CONCLUSIONS
  patients showed disturbances in clinical nutritional parameters which confirm their hypercatabolic situation, showing malnutrition state at admission, where 42.9% had plasma levels below the reference prealbumin. Amino acid profile was situated below the reference values and 99% of patients had low plasma transferrin. Significant differences were observed in total protein, ferritin and transferrin parameters adjusted by CRP levels, being higher when patients presented high inflammation in the case of ferritin and the opposite for the rest of parameters. Adjusting APACHE and SOFA scores according to low, medium and high severity, results showed significant differences in creatinine, urea, and transferrin, being lower at high severity grade for the last one.
  
  
  CONCLUSIONS
  critical illness is characterized by a high degree of stress and accelerated degradation of proteins that cause malnutrition, systemic inflammation and organ dysfunction, with a significant association between albumin, ferritin and transferrin.
authors.affiliation: Department of Physiology, Institute of Nutrition and Food Technology "José Mataix", University of Granada, Granada, Spain.. ihicham0079@gmail.com.
authors.forename: Hicham
authors.initials: H
authors.lastname: Bouharras El Idrissi
authors.affiliation: Department of Physiology, Institute of Nutrition and Food Technology "José Mataix", University of Granada, Granada, Spain.. jrgmolinalopez@ugr.es.
authors.forename: Jorge
authors.initials: J
authors.lastname: Molina López
authors.affiliation: Department of Physiology, Institute of Nutrition and Food Technology "José Mataix", University of Granada, Granada, Spain.. irepemo@gmail.com.
authors.forename: Irene
authors.initials: I
authors.lastname: Pérez Moreno
authors.affiliation: Moorfields Hospital. University College Hospital, London, UK.. bio_dana@yahoo.com.
authors.forename: Daniela Ioana
authors.initials: DI
authors.lastname: Florea
authors.affiliation: Nutrition & Dietetic Unit. Virgen de las Nieves Hospital, Granada, Spain.. gabylobotamer@gmail.com.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Lobo Támer
authors.affiliation: Department of Physiology, Institute of Nutrition and Food Technology "José Mataix", University of Granada, Granada, Spain. Department of Physical Chemistry, Faculty of Pharmacy, University of Granada, Granada, Spain.. lourdes_hq@hotmail.com.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Herrera-Quintana
authors.affiliation: Nutrition & Dietetic Unit. Virgen de las Nieves Hospital, Granada, Spain. Intensive Care Unit. Virgen de las Nieves Hospital, Granada, Spain.. antonioj.perez.sspa@juntadeandalucia.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pérez De La Cruz
authors.affiliation: Intensive Care Unit. Virgen de las Nieves Hospital, Granada, Spain.. manuel.rodriguez.elvira.sspa@juntadeandalucia.es.
authors.forename: Manuel
authors.initials: M
authors.lastname: Rodríguez Elvira
authors.affiliation: Department of Physiology, Institute of Nutrition and Food Technology "José Mataix", University of Granada, Granada, Spain.. elenamp@ugr.es.
authors.forename: Elena María
authors.initials: EM
authors.lastname: Planells Del Pozo
mesh_terms: D018806:APACHE; D000368:Aged; D000596:Amino Acids / Q000378:metabolism; D016638:Critical Illness; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D009752:Nutritional Status; D010343:Patient Admission; D011446:Prospective Studies; D011506:Proteins / Q000378:metabolism*; D018746:Systemic Inflammatory Response Syndrome / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D011506:Proteins