title: [Research on radiation sensitization effect of microRNA and clinical perspectives in nasopharyngeal carcinoma].
abstract: Radiotherapy is the primary treatment for nasopharyngeal carcinoma, and the disease control rate and survival time are able to be greatly improved by enhancing the radiosensitivity. Via mechanisms such as binding to target genes mRNA 3'untranslated region (3'UTR), microRNA (miRNA) inhibits translation, which therefore regulates transcription of target genes and thus affect target protein expression. Recent research showed that miRNAs play significant roles in improvement of radiosensitivity in nasopharyngeal carcinoma. This article reviews mechanism of miRNA action to strengthen radiosensitivity of nasopharyngeal carcinoma and the future of clinical practice of miRNA in this disease.
authors.forename: Teng
authors.initials: T
authors.lastname: Huang
authors.forename: Li
authors.initials: L
authors.lastname: Yin
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
mesh_terms: D020413:3' Untranslated Regions; D002277:Carcinoma; D006801:Humans; D035683:MicroRNAs / Q000494:pharmacology*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D012333:RNA, Messenger; D011836:Radiation Tolerance; D011838:Radiation-Sensitizing Agents
chemical_list: D020413:3' Untranslated Regions; D035683:MicroRNAs; D012333:RNA, Messenger; D011838:Radiation-Sensitizing Agents