title: Assessment of dexmedetomidine and other agents for emesis induction in cats: 43 cases (2009-2014).
abstract: OBJECTIVE
  To compare the use of dexmedetomidine hydrochloride, xylazine hydrochloride, and hydrogen peroxide for emesis induction in cats.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  43 client-owned cats for which emesis induction was attempted because of known or suspected toxicant ingestion or recent ingestion of a string foreign body.
  
  
  METHODS
  Data collected from the cats' medical records included type, dose, and route of administration of emetic agent; outcome of attempted emesis induction; time until emesis or postemesis administration of a reversal agent (to counter sedative effects of the emetic agent); and adverse events.
  
  
  RESULTS
  Emesis induction was attempted by oral administration of hydrogen peroxide (n = 3) or IM or IV administration of xylazine (25 [including 1 cat that had already received hydrogen peroxide]) or dexmedetomidine (16). No cat that received hydrogen peroxide vomited. Emesis was induced in 11 of 25 xylazine-treated cats and in 13 of 16 dexmedetomidine-treated cats. Dexmedetomidine was more likely to cause vomiting than xylazine (OR, 5.5; 95% confidence interval, 1.1 to 36). The median dose of dexmedetomidine that caused emesis was 7.0 μg/kg (3.2 μg/lb; range, 0.96 to 10.0 μg/kg [0.44 to 4.55 μg/lb]). The elapsed time until emesis or postemesis reversal agent administration was recorded for 5 xylazine-treated cats (median interval, 10 minutes [range, 5 to 175 minutes]) and 10 dexmedetomidine-treated cats (median interval, 5 minutes [range, 1 to 12 minutes]). Sedation was the only adverse effect, occurring in 2 xylazine-treated cats and 1 dexmedetomidine-treated cat.
  
  
  CONCLUSIONS
  Results indicated that dexmedetomidine can be used successfully to induce emesis in cats.
authors.forename: Vincent J
authors.initials: VJ
authors.lastname: Thawley
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Drobatz
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000627:therapeutic use; D000818:Animals; D002371:Cat Diseases / Q000139:chemically induced; D002415:Cats; D020927:Dexmedetomidine / Q000627:therapeutic use*; D004639:Emetics / Q000627:therapeutic use*; D005260:Female; D005547:Foreign Bodies / Q000628:therapy / Q000662:veterinary*; D008297:Male; D011041:Poisoning / Q000628:therapy / Q000662:veterinary; D012189:Retrospective Studies; D014839:Vomiting / Q000139:chemically induced / Q000662:veterinary*; D014991:Xylazine / Q000627:therapeutic use*
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D004639:Emetics; D014991:Xylazine; D020927:Dexmedetomidine