title: Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine.
authors.affiliation: Department of Neurology, University of Virginia, Charlottesville, Virginia, 22908, USA.
authors.forename: Ted M
authors.initials: TM
authors.lastname: Burns
authors.affiliation: Department of Neurology University of Utah, Salt Lake City, Utah, USA.
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Smith
authors.affiliation: Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Allen
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Amato
authors.affiliation: Department of Neurology and Physical Medicine and Rehabilitation, Ohio State University, Columbus, Ohio, USA.
authors.forename: W David
authors.initials: WD
authors.lastname: Arnold
authors.affiliation: Department of Neurology, University of Kansas, Kansas City, Kansas, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Barohn
authors.affiliation: Department of Neurology, University of Miami, Miami, Florida, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Benatar
authors.affiliation: Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: Shawn J
authors.initials: SJ
authors.lastname: Bird
authors.affiliation: Department of Neurology University of Utah, Salt Lake City, Utah, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Bromberg
authors.affiliation: Department of Neurology, University of Connecticut, Farmington, Connecticut, USA.
authors.forename: Nizar
authors.initials: N
authors.lastname: Chahin
authors.affiliation: Department of Neurology, University of Rochester, Rochester, New York, USA.
authors.forename: Emma
authors.initials: E
authors.lastname: Ciafaloni
authors.affiliation: Department of Neurology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Cohen
authors.affiliation: Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Corse
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Crum
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: William S
authors.initials: WS
authors.lastname: David
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
authors.forename: Elliot
authors.initials: E
authors.lastname: Dimberg
authors.affiliation: Department of Neurology, University of Oklahoma, Oklahoma City, Oklahoma, USA.
authors.forename: Eduardo A De
authors.initials: EA
authors.lastname: Sousa
authors.affiliation: Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Donofrio
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: P James B
authors.initials: PJ
authors.lastname: Dyck
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Engel
authors.affiliation: Department of Neurology, Boston Veterans Affairs, Boston, Massachusetts, USA.
authors.forename: Erik R
authors.initials: ER
authors.lastname: Ensrud
authors.affiliation: Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Ferrante
authors.affiliation: Department of Neurology, Ohio State University, Columbus, Ohio, USA.
authors.forename: Miriam
authors.initials: M
authors.lastname: Freimer
authors.affiliation: Department of Neurology, Duke University, Durham, North Carolina, USA.
authors.forename: Karissa L
authors.initials: KL
authors.lastname: Gable
authors.affiliation: Department of Neurology University of Utah, Salt Lake City, Utah, USA.
authors.forename: Summer
authors.initials: S
authors.lastname: Gibson
authors.affiliation: Department of Neurology, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Gilchrist
authors.affiliation: Department of Neurology, Hospital for Special Surgery, New York, New York, USA.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Goldstein
authors.affiliation: Department of Neurology, University of South Florida, Tampa, Florida, USA.
authors.forename: Clifton L
authors.initials: CL
authors.lastname: Gooch
authors.affiliation: Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA.
authors.forename: Brent P
authors.initials: BP
authors.lastname: Goodman
authors.affiliation: Crystal Run Healthcare, Middletown, New York, USA.
authors.forename: Dmitri
authors.initials: D
authors.lastname: Gorelov
authors.affiliation: Department of Neurology, University of Washington, Seattle, Washington, USA.
authors.forename: Sidney M
authors.initials: SM
authors.lastname: Gospe
authors.affiliation: Department of Neurology, University of California Irvine, Irvine, California, USA.
authors.forename: Namita A
authors.initials: NA
authors.lastname: Goyal
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Amanda C
authors.initials: AC
authors.lastname: Guidon
authors.affiliation: Department of Neurology, Duke University, Durham, North Carolina, USA.
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Guptill
authors.affiliation: Division of Neurology, University of Iowa, Iowa City, Iowa, USA.
authors.forename: Laurie
authors.initials: L
authors.lastname: Gutmann
authors.affiliation: Division of Neurology, University of Iowa, Iowa City, Iowa, USA.
authors.forename: Ludwig
authors.initials: L
authors.lastname: Gutmann
authors.affiliation: Department of Neurology, University of Virginia, Charlottesville, Virginia, 22908, USA.
authors.forename: Kelly
authors.initials: K
authors.lastname: Gwathmey
authors.affiliation: Department of Neurology, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Yadollah
authors.initials: Y
authors.lastname: Harati
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: C Michel
authors.initials: CM
authors.lastname: Harper
authors.affiliation: Department of Neurology, University of Vermont, Burlington, Vermont, USA.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Hehir
authors.affiliation: Department of Neurology, Duke University, Durham, North Carolina, USA.
authors.forename: Lisa D
authors.initials: LD
authors.lastname: Hobson-Webb
authors.affiliation: Department of Neurology, University of North Carolina, Chapel Hill, North Carolina, USA.
authors.forename: James F
authors.initials: JF
authors.lastname: Howard
authors.affiliation: Department of Neurology and Otolaryngology, University of Texas Health Science Center, San Antonio, Texas, USA.
authors.forename: Carlayne E
authors.initials: CE
authors.lastname: Jackson
authors.affiliation: Department of Neurology University of Utah, Salt Lake City, Utah, USA.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Johnson
authors.affiliation: Department of Neurology, University of Virginia, Charlottesville, Virginia, 22908, USA.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Jones
authors.affiliation: Department of Neurology, Duke University, Durham, North Carolina, USA.
authors.forename: Vern C
authors.initials: VC
authors.lastname: Juel
authors.affiliation: Department of Neurology, George Washington University, Washington, DC, USA.
authors.forename: Henry J
authors.initials: HJ
authors.lastname: Kaminski
authors.affiliation: Department of Neurology, University of North Carolina, Chapel Hill, North Carolina, USA.
authors.forename: Chafic
authors.initials: C
authors.lastname: Karam
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
authors.forename: Kathleen D
authors.initials: KD
authors.lastname: Kennelly
authors.affiliation: Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: Sami
authors.initials: S
authors.lastname: Khella
authors.affiliation: Department of Neurology, Oregon Health Science University, Portland, Oregon, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Khoury
authors.affiliation: Department of Neurology, Indiana University, Indianapolis, Indiana, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Kincaid
authors.affiliation: Department of Neurology, Ohio State University, Columbus, Ohio, USA.
authors.forename: John T
authors.initials: JT
authors.lastname: Kissel
authors.affiliation: Department of Neurology University of Utah, Salt Lake City, Utah, USA.
authors.forename: Noah
authors.initials: N
authors.lastname: Kolb
authors.affiliation: Department of Neurology and Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: David
authors.initials: D
authors.lastname: Lacomis
authors.affiliation: Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA.
authors.forename: Shafeeq
authors.initials: S
authors.lastname: Ladha
authors.affiliation: Department of Neurology, Ochsner Neuroscience Institute, New Orleans, Louisiana, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Larriviere
authors.affiliation: Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Lewis
authors.affiliation: Department of Neurology, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Yuebing
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Litchy
authors.affiliation: Department of Neurology, University of Rochester, Rochester, New York, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Logigian
authors.affiliation: Department of Neurology, University of North Dakota, Sanford Health, Fargo, North Dakota, USA.
authors.forename: Jau-Shin
authors.initials: JS
authors.lastname: Lou
authors.affiliation: Department of Neurology, Department of Neurology, Mount Sinai Beth Israel Hospital, New York, New York, USA.
authors.forename: Daniel J L
authors.initials: DJ
authors.lastname: MacGowen
authors.affiliation: Department of Neurology, University of California, Davis, Sacramento, California, USA.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Maselli
authors.affiliation: Department of Neurology, Duke University, Durham, North Carolina, USA.
authors.forename: Janice M
authors.initials: JM
authors.lastname: Massey
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Mauermann
authors.affiliation: Division of Neurology, University of Iowa, Iowa City, Iowa, USA.
authors.forename: Katherine D
authors.initials: KD
authors.lastname: Mathews
authors.affiliation: Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
authors.forename: Matthew N
authors.initials: MN
authors.lastname: Meriggioli
authors.affiliation: Department of Neurosciences, California Pacific Medical Center, San Francisco, California, USA.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Miller
authors.affiliation: Department of Neurology, University of Oklahoma, Oklahoma City, Oklahoma, USA.
authors.forename: Joon-Shik
authors.initials: JS
authors.lastname: Moon
authors.affiliation: Department of Neurology, University of California Irvine, Irvine, California, USA.
authors.forename: Tahseen
authors.initials: T
authors.lastname: Mozaffar
authors.affiliation: Department of Neurology and Neurotherapeutics, University Texas Southwestern, Dallas, Texas, USA.
authors.forename: Sharon P
authors.initials: SP
authors.lastname: Nations
authors.affiliation: Department of Neurology, Yale School of Medicine, New Haven, Connecticut, USA.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Nowak
authors.affiliation: Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Lyle W
authors.initials: LW
authors.lastname: Ostrow
authors.affiliation: Department of Neurology, Indiana University, Indianapolis, Indiana, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Pascuzzi
authors.affiliation: Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Peltier
authors.affiliation: Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Katherine
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authors.lastname: Ruzhansky
authors.affiliation: Department of Neurology, University of California, Davis, Sacramento, California, USA.
authors.forename: David P
authors.initials: DP
authors.lastname: Richman
authors.affiliation: Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Ross
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
authors.forename: Devon I
authors.initials: DI
authors.lastname: Rubin
authors.affiliation: Department of Neurology, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA.
authors.forename: James A
authors.initials: JA
authors.lastname: Russell
authors.affiliation: Department of Neurology, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
authors.forename: George M
authors.initials: GM
authors.lastname: Sachs
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Mohammad Kian
authors.initials: MK
authors.lastname: Salajegheh
authors.affiliation: Phoenix Neurological Associates, Phoenix, Arizona, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Saperstein
authors.affiliation: Department of Neurology, Department of Neurology, Mount Sinai Beth Israel Hospital, New York, New York, USA.
authors.forename: Stephen
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authors.lastname: Scelsa
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Duygu
authors.initials: D
authors.lastname: Selcen
authors.affiliation: Nerve and Muscle Center of Texas, Houston, Texas, USA.
authors.forename: Aziz
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authors.lastname: Shaibani
authors.affiliation: Department of Neurology, University of California at Los Angeles, Los Angeles, California, USA.
authors.forename: Perry B
authors.initials: PB
authors.lastname: Shieh
authors.affiliation: Department of Neurology, University of Buffalo, Buffalo, New York, USA.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Silvestri
authors.affiliation: Department of Neurology University of Utah, Salt Lake City, Utah, USA.
authors.forename: J Rob
authors.initials: JR
authors.lastname: Singleton
authors.affiliation: Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA.
authors.forename: Benn E
authors.initials: BE
authors.lastname: Smith
authors.affiliation: Department of Neurology, Stanford University, Palo Alto, California, USA.
authors.forename: Yuen T
authors.initials: YT
authors.lastname: So
authors.affiliation: Department of Neurology, University of Virginia, Charlottesville, Virginia, 22908, USA.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Solorzano
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Sorenson
authors.affiliation: Department of Neurology, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA.
authors.forename: Jayashri
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authors.lastname: Srinivasen
authors.affiliation: Department of Neurology, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Jinny
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authors.lastname: Tavee
authors.affiliation: Department of Neurology, University of Rochester, Rochester, New York, USA.
authors.forename: Rabi
authors.initials: R
authors.lastname: Tawil
authors.affiliation: Department of Neurology, University of Nebraska, Omaha, Nebraska, USA.
authors.forename: Pariwat
authors.initials: P
authors.lastname: Thaisetthawatkul
authors.affiliation: Department of Neurology, University of Rochester, Rochester, New York, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Thornton
authors.affiliation: Department of Neurology, Yale School of Medicine, New Haven, Connecticut, USA.
authors.forename: Jaya
authors.initials: J
authors.lastname: Trivedi
authors.affiliation: Department of Neurology and Neurotherapeutics, University Texas Southwestern, Dallas, Texas, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Vernino
authors.affiliation: Department of Neurology, Veterans Affairs Long Beach Healthcare System, Long Beach, California, USA.
authors.forename: Annabel K
authors.initials: AK
authors.lastname: Wang
authors.affiliation: Department of Neurology, University of Oklahoma, Oklahoma City, Oklahoma, USA.
authors.forename: Tyler A
authors.initials: TA
authors.lastname: Webb
authors.affiliation: Department of Neurology, University of Washington, Seattle, Washington, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Weiss
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Windebank
authors.affiliation: Department of Neurology, University of Buffalo, Buffalo, New York, USA.
authors.forename: Gil I
authors.initials: GI
authors.lastname: Wolfe
mesh_terms: D015761:4-Aminopyridine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077770:Amifampridine; D006801:Humans; D020511:Neuromuscular Junction Diseases / Q000188:drug therapy* / Q000191:economics; D009965:Orphan Drug Production / Q000191:economics / Q000379:methods; D010820:Physicians / Q000523:psychology*; D026902:Potassium Channel Blockers / Q000627:therapeutic use*
chemical_list: D026902:Potassium Channel Blockers; D015761:4-Aminopyridine; D000077770:Amifampridine