title: Cortical auditory evoked responses of older adults with and without probable mild cognitive impairment.
abstract: OBJECTIVE
  Hearing loss has been well-documented as a risk factor for cognitive impairment, but the simple presence of hearing loss is not a sufficient predictor of cognitive decline. Although auditory behavioral research has not revealed an effective indicator of early cognitive impairment, a limited number of studies using cortical auditory evoked potentials (CAEPs) have shown promising evidence of an auditory neurophysiological indicator of early-stage cognitive impairment. The purpose of this study was to examine the P1-N1-P2 complex for indicators of cognitive impairment.
  
  
  METHODS
  The latency and amplitude of the P1-N1-P2 complex was measured for two stimuli (pure tone, speech) in two groups: cognitively normal older adults (CNOAs) and older adults with probable mild cognitive impairment (MCI), based on the Montreal Cognitive Assessment.
  
  
  RESULTS
  Significantly smaller P2 amplitudes were found for those with probable MCI compared to CNOA across stimulus conditions. Stimulus effects were found for P1 and P2 latency.
  
  
  CONCLUSIONS
  P2 amplitude may be a useful indicator of early-stage cognitive impairment.
  
  
  CONCLUSIONS
  As effective treatments become available, early identification of cognitive impairment can facilitate the prescription of treatment at the earliest juncture. CAEPs have the potential to serve as efficient, non-invasive, cost-effective indicators of future cognitive decline and impairment.
authors.affiliation: Department of Communication Sciences and Disorders, University of South Florida, Tampa, FL, USA; School of Aging Studies, University of South Florida, Tampa, FL, USA; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA. Electronic address: jlister@usf.edu.
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Lister
authors.affiliation: Department of Communication Sciences and Disorders, University of South Florida, Tampa, FL, USA; School of Aging Studies, University of South Florida, Tampa, FL, USA; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
authors.forename: Aryn L
authors.initials: AL
authors.lastname: Harrison Bush
authors.affiliation: School of Aging Studies, University of South Florida, Tampa, FL, USA; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
authors.forename: Ross
authors.initials: R
authors.lastname: Andel
authors.affiliation: Department of Communication Sciences and Disorders, University of South Florida, Tampa, FL, USA.
authors.forename: Courtney
authors.initials: C
authors.lastname: Matthews
authors.affiliation: USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
authors.forename: David
authors.initials: D
authors.lastname: Morgan
authors.affiliation: Department of Communication Sciences and Disorders, University of South Florida, Tampa, FL, USA; School of Aging Studies, University of South Florida, Tampa, FL, USA; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
authors.forename: Jerri D
authors.initials: JD
authors.lastname: Edwards
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology* / Q000523:psychology; D001303:Auditory Cortex / Q000503:physiopathology*; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D004569:Electroencephalography / Q000379:methods; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male
keywords: Aging; Cognition; Cortical auditory evoked potentials; Hearing; Mild cognitive impairment; P1–N1–P2 complex