title: Antimycobacterial Natural Products from Endophytes of the Medicinal Plant Aralia nudicaulis.
abstract: Antimycobacterial extracts of a Penicillium sp. (isolate HL4-159-41B) and a Coniothyrium sp. (isolate HL6-097-027B) isolated from the rhizomes of the Canadian medicinal plant Aralia nudicaulis were found to contain palitantin (1) and botrallin (2), craterellin C (3), mycosporulone (4), spiromassaritone (5), and massarigenin D (6) respectively. Bioassays against Mycobacterium tuberculosis H37Ra revealed that 1 - 4 possess moderate antimycobacterial activity.
authors.forename: Haoxin
authors.initials: H
authors.lastname: Li
authors.forename: Brandon
authors.initials: B
authors.lastname: Doucet
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Flewelling
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Jean
authors.forename: Duncan
authors.initials: D
authors.lastname: Webster
authors.forename: Gilles A
authors.initials: GA
authors.lastname: Robichaud
authors.forename: John A
authors.initials: JA
authors.lastname: Johnson
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Gray
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D027983:Aralia / Q000382:microbiology*; D001203:Ascomycota / Q000737:chemistry / Q000378:metabolism*; D060026:Endophytes / Q000737:chemistry / Q000378:metabolism*; D057809:HEK293 Cells; D006801:Humans; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*
chemical_list: D000995:Antitubercular Agents