title: Acid-base optimization during hypothermia.
abstract: Cardiac arrest (CA) often results in hemodynamic and metabolic compromise with associated poor prognosis. Therapeutic hypothermia (TH) has become the standard of care for CA survivors, decreasing reperfusion injury and intercellular acid-base disturbances, with improved neurologic outcomes. These benefits are realized despite a mild acidosis that can potentially occur during TH. By contrast, the severity of acidosis after return of spontaneous circulation (ROSC) must be monitored carefully and managed appropriately. Bicarbonate should be used only in case of severe acidosis and as a continuous infusion. The blood gas samples are usually warmed to 37 °C before analysis; hence, it is worth noting that the blood gas values are temperature dependent. Therefore, a calculated correction for values may be necessary.
authors.affiliation: University of Connecticut School of Medicine, The Hospital of Central Connecticut, 100 Grand Street, New Britain, CT 06050, USA. Electronic address: bergman@uchc.edu.
authors.forename: Leah
authors.initials: L
authors.lastname: Bergman
authors.affiliation: University of Connecticut School of Medicine, The Hospital of Central Connecticut, 100 Grand Street, New Britain, CT 06050, USA. Electronic address: Justin.Lundbye@hhchealth.org.
authors.forename: Justin B
authors.initials: JB
authors.lastname: Lundbye
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology*; D000137:Acid-Base Imbalance / Q000097:blood / Q000517:prevention & control*; D000138:Acidosis / Q000097:blood / Q000517:prevention & control; D006323:Heart Arrest / Q000097:blood / Q000628:therapy*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007036:Hypothermia, Induced / Q000379:methods* / Q000639:trends
keywords: acidosis; alpha-stat; cardiac arrest; lactic acid; pH-stat; therapeutic hypothermia