title: Is there any place for resistant starch, as alimentary prebiotic, for patients with type 2 diabetes?
abstract: OBJECTIVE
  The aim of the present study was to determine effects of Resistant Starch (RS2) on metabolic parameters and inflammation in women with type 2 diabetes (T2DM).
  
  
  METHODS
  In this randomized controlled clinical trial, 60 females with T2DM were divided into intervention (n = 28) and placebo groups (n = 32). They received 10 g/d RS2 or placebo for 8 weeks, respectively. Fasting blood sugar (FBS), glycated hemoglobin (HbA1c), lipid profile, high-sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were measured at baseline and at the end of the trial. Paired t test, unpaired t-test and ANCOVA were used to compare the quantitative variables. The data were analyzed using SPSS software version 13.0.
  
  
  RESULTS
  RS2 decreased HbA1c (-0.3%, -3.6%), TNF-α (-3.4 pg/mL, -18.9%), triglyceride (-33.4 mg/dL, -15.4%), and it increased HDL-c (+9.4 mg/dL, +24.6%) significantly compared with the placebo group (p < 0.05). Changes in FBS, total cholesterol, low-density lipoprotein, hs-CRP and IL-6 were not significant in the RS2 group compared with the control group. RS2 can improve glycemic status, inflammatory markers and lipid profile in women with T2DM.
  
  
  CONCLUSIONS
  Although findings of the present study indicated positive effects of RS2 on inflammation and metabolic parameters, more studies are needed to confirm efficacy of RS2 as an adjunct therapy in diabetes.
authors.affiliation: Department of biochemistry & Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Bahram Pourghassem
authors.initials: BP
authors.lastname: Gargari
authors.affiliation: Faculty of Nutrition, Nutrition Research Center, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Nazli
authors.initials: N
authors.lastname: Namazi
authors.affiliation: Neurosciences Research Center Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Khalili
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: Bahareh
authors.initials: B
authors.lastname: Sarmadi
authors.affiliation: Traffic Injury Prevention Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad Asghari
authors.initials: MA
authors.lastname: Jafarabadi
authors.affiliation: Faculty of Nutrition, Nutrition Research Center, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: dehghan.nut@gmail.com.
authors.forename: Parvin
authors.initials: P
authors.lastname: Dehghan
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007249:Inflammation / Q000178:diet therapy*; D007492:Iran; D008875:Middle Aged; D056692:Prebiotics
chemical_list: D001786:Blood Glucose; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D056692:Prebiotics; C517652:hemoglobin A1c protein, human
keywords: Inflammation; Lipid profile; Resistant starch; Type 2 diabetes