title: Development of Scaffolds for Vascular Tissue Engineering: Biomaterial Mediated Neovascularization.
abstract: Cardiovascular diseases remain the leading cause of mortality or disabled quality of life for people over the world. The necessity of neovascularization is essential for re-establishing the tissue functions after a major lesion that occurs in patients with cardiovascular disorders, such as ischemia, atherosclerosis, diabetes, peripheral vascular disease and burn wounds. This review focuses on the recent data regarding the polymers and scaffolds that are used for improving neovascularization with emphasis on the biocompatibility and mechanisms involved in stem cells proliferation, migration, adherence, differentiation and organization in vascular networks. The newly emerging techniques used in conjugation of synthetic polymers with polysaccharides or proteins attempt to improve the biocompatibility of scaffolds, but the complex structures of blood vessels make their construction to remain a major challenge for the vascular tissue engineering.
authors.affiliation: Institute of Cellular Biology and Pathology "Nicolae Simionescu" of Romanian Academy, Department of Fetal and Adult Stem Cell Therapy, 050568, Bucharest, Romania.
authors.forename: Florin
authors.initials: F
authors.lastname: Iordache
authors.forename: Alexandru Mihai
authors.initials: AM
authors.lastname: Grumezescu
authors.forename: Horia
authors.initials: H
authors.lastname: Maniu
authors.forename: Carmen
authors.initials: C
authors.lastname: Curutiu
mesh_terms: D050197:Atherosclerosis / Q000473:pathology / Q000601:surgery; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000494:pharmacology; D001808:Blood Vessels / Q000166:cytology* / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003920:Diabetes Mellitus / Q000473:pathology / Q000601:surgery; D042783:Endothelial Cells / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D006801:Humans; D017202:Myocardial Ischemia / Q000473:pathology / Q000601:surgery; D018919:Neovascularization, Physiologic / Q000187:drug effects; D016491:Peripheral Vascular Diseases / Q000473:pathology / Q000601:surgery; D011108:Polymers / Q000138:chemical synthesis / Q000494:pharmacology; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D011108:Polymers
keywords: Bioprinter; natural polymers; neovascularization; stem cells; synthetic polymers.