title: [Safety of percutaneous coronary intervention in patients with acute coronary syndromes complicating chronic kidney disease].
abstract: OBJECTIVE
  To evaluate the safety of percutaneous coronary intervention (PCI) in patients with acute coronary syndromes (ACS) complicating chronic kidney disease (CKD).
  
  
  METHODS
  We retrospectively evaluated the medical data of 335 patients hospitalized in our hospital with a diagnosis of ACS and CKD between 1 January 2011 and 30 May 2014. Patients were divided into two groups: PCI group who received PCI treatment during hospitalization (n = 135) and non-PCI group who did not receive PCI treatment (n = 200). Multivariable logistic regression analysis was performed to evaluate the connection between PCI and in-hospital death and acute renal insufficiency.
  
  
  RESULTS
  The median GFR level of 335 patients was 36.26 (25.09-47.65) ml · min⁻¹ · 1.73 m⁻². GFR level was similar between the two groups (P = 0.205). Multivariable logistic regression analysis showed that PCI did not increase the risk of in-hospital death (OR = 0.465, 95% CI: 0.190-1.136, P = 0.093) and in-hospital acute renal insufficiency (OR = 0.830, 95% CI: 0.375-1.836, P = 0.669). In patients of 45 ml · min⁻¹ · 1.73 m⁻² ≤ GFR < 60 ml · min⁻¹ · 1.73 m⁻², 30 ml · min⁻¹ · 1.73 m⁻² ≤ GFR < 45 ml · min⁻¹ · 1.73 m⁻² and GFR < 30 ml · min⁻¹ · 1.73 m⁻², the OR of in-hospital death in PCI group were 0.235 (95% CI: 0.024-2.301, P = 0.213), 0.640 (95% CI: 0.112-3.649, P = 0.616) and 0.919 (95% CI: 0.159-5.307, P = 0.925), and the OR of in-hospital acute renal insufficiency were 0.436 (95% CI: 0.120-1.587, P = 0.208), 2.209 (95% CI: 0.394-12.391, P = 0.368) and 0.724 (95% CI: 0.127-4.117, P = 0.716) indicating that PCI did not increase above events in ACS patients complicating CKD.
  
  
  CONCLUSIONS
  PCI does not increase the risk of in-hospital death and in-hospital acute renal insufficiency in ACS patients complicating CKD.
authors.affiliation: Department of Cardiology, Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Department of Cardiology, Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China.
authors.forename: Kuibao
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Cardiology, Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China; Email: yxc6229@sina.com.
authors.forename: Xinchun
authors.initials: X
authors.lastname: Yang
mesh_terms: D054058:Acute Coronary Syndrome; D058186:Acute Kidney Injury; D006760:Hospitalization; D006801:Humans; D062645:Percutaneous Coronary Intervention; D051436:Renal Insufficiency, Chronic; D012189:Retrospective Studies