title: Alzheimer's Genetic Risk Intensifies Neurocognitive Slowing Associated with Diabetes in Non-Demented Older Adults.
abstract: BACKGROUND
  We examine interactive and intensification effects of type 2 diabetes (T2D) withAPOEand an Alzheimer's disease Genetic Risk Score (GRS) on neurocognitive speed performance and change in non-demented older adults.
  
  
  METHODS
  In an accelerated longitudinal design, we used latent growth modeling to test moderators of level and change in a neurocognitive speed latent variable for 628 adults (baselineMage=69.0) followed over 9 years. The GRS was compiled using the cumulative risk ofAPOE, CLU,CR1, andPICALM.
  
  
  RESULTS
  First, T2D predicted slower speed performance at centering age (75). Second, no predictive effects were associated withAPOEor GRS. Third, a significant interaction showed that high risk from both T2D and GRS was selectively associated with steeper longitudinal slowing than all comparison cross-domain risk groups.
  
  
  CONCLUSIONS
  Higher AD-related genetic risk intensified deleterious effects of diabetes on neurocognitive slowing in non-demented aging beyond the independent influence ofAPOE.
authors.affiliation: Department of Psychology, University of Alberta, Edmonton, AB, Canada.
authors.forename: G Peggy
authors.initials: GP
authors.lastname: McFall
authors.affiliation: Department of Psychology, University of Alberta, Edmonton, AB, Canada; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
authors.forename: Sandra A
authors.initials: SA
authors.lastname: Wiebe
authors.affiliation: Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, AB, Canada; Campus Saint-Jean, University of Alberta, Edmonton, AB, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Vergote
authors.affiliation: Centre for Research on Ageing, Health and Wellbeing, Research School of Population Health, The Australian National University, Canberra, ACT, Australia.
authors.forename: Kaarin J
authors.initials: KJ
authors.lastname: Anstey
authors.affiliation: Department of Psychology, University of Alberta, Edmonton, AB, Canada; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
authors.forename: Roger A
authors.initials: RA
authors.lastname: Dixon
keywords: APOE; Alzheimer's disease genetic risk score; Neurocognitive speed; Type 2 Diabetes; Victoria Longitudinal Study