title: Synthesis ofβ-triphosphotriester pronucleotides.
abstract: Dinucleoside phosphorochloridite were synthesized from phosphorus trichloride and three nucleoside analogues, 3'-fluoro-2',3'-dideoxythymidine (FLT), 2',3'-dideoxy-5-fluoro-3'-thiacytidine (FTC), and 2',3'-dideoxy-3'-thiacytidine (3TC), in a multistep synthesis. Polymer-boundN-Bocp-acetoxybenzyl 5'-O-2'-deoxythymidine was reacted with dinucleoside phosphorochloridite in the presence of 2,6-lutidine, followed by the reaction with dodecyl alcohol and 5-(ethylthio)-1H-tetrazole, oxidation withtert-butyl hydroperoxide, and acidic cleavage, respectively, to afford theβ-triphosphotriester derivatives containing three different nucleosides.
authors.affiliation: Department of Chemistry, Tennessee State University, Nashville, TN, USA 37209.
authors.forename: Yousef
authors.initials: Y
authors.lastname: Beni
authors.affiliation: Center for AIDS Health Disparities Research, Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN, USA 37208.
authors.forename: Chandravanu
authors.initials: C
authors.lastname: Dash
authors.affiliation: Chapman University School of Pharmacy, Irvine, CA, USA 92618 ; Chao Family Comprehensive Cancer Center, School of Medicine, University of California, Irvine, Shanbrom Hall, 101 The City Drive, Orange, CA, USA 92868.
authors.forename: Keykavous
authors.initials: K
authors.lastname: Parang
keywords: Fatty chains; Nucleosides; Nucleotides; Pronucleotides; Triphosphotriesters