title: [SSRI AND BONE METABOLISM IN HIV + PATIENTS WITH ANTIRETROVIRAL THERAPY].
abstract: We report a series of 9 male HIV + patients, average age of 41.2 years, viral load negative (<50 copies RNA/ml), treated with antiretroviral (nucleoside and non-nucleoside inhibitors of reverse transcriptase) without systemic infections, the CNS diseases or marker or corticoidoterapia in progress. Were evaluated and supported by their infectologists interconsultation during the period October 2008-October 2013 by depressive syndrome. Psychotherapeutic and psychiatric treatment was initiated with SSRIs and clonazepam; Neuroimaging control and biochemical laboratory studies at baseline and 2 months of treatment were conducted. In the course of psychopharmacological treatment not suffer fractures due to falls and alterations were detected in bone metabolism markers and images. He studied with endocrinology and interdisciplinary medical clinic, decided to withdraw the SSRIs with normalization of biochemical values and psychotherapeutic treatment was continued. We will raise the associations between the use of SSRIs, disturbances of bone metabolism with clinical correlation and possible drug interactions between antidepressants and antiretroviral.
authors.forename: Martín J
authors.initials: MJ
authors.lastname: Mazzoglio y Nabar
authors.forename: Milagros María
authors.initials: MM
authors.lastname: Muñiz
authors.forename: Alexis A
authors.initials: AA
authors.lastname: Mejías Delamano
authors.forename: Santiago
authors.initials: S
authors.lastname: Muñoz
authors.forename: Nahuel
authors.initials: N
authors.lastname: Magrath Guimet
mesh_terms: D000328:Adult; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism*; D003863:Depression / Q000188:drug therapy / Q000209:etiology; D006679:HIV Seropositivity / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D018894:Reverse Transcriptase Inhibitors; D017367:Selective Serotonin Reuptake Inhibitors