title: [Chronic renal failure in sickle cell disease: A retrospective analysis of 100 adults sickle cell patients from black Africa].
abstract: The prevalence of chronic renal failure (CRF) in sickle cell disease (SCD) patients could vary from one country to another depending on the modalities of management. The aim of the present study was to appreciate the epidemiology of CRF in SCD patients from black Africa in order to search for promoting factors. One hundred SCD adult patients have been considered for the study. The glomerular filtration rate (GFR) has been estimated according to the CKD-EPI formula. Three groups of patients have been identified according to the value of their GFR. The mean age of the patients was 30.84±8.26 years. Male gender has represented 51% of the study population. The mean GFR value was 175.4±86.2 mL/min/1.73 m(2). The prevalence of CRF was 11%. About 3% of them had severe CRF. Subjects with normal GFR were 20%. Subjects with glomerular hyperfiltration (HF) were 69%. By univariate analysis, when subjects with HF were compared with those presenting normal GFR, the following factors have appeared to be significantly associated: female gender (female 60.9% versus male 39.1%; P<0.01), weight <60 kg (weight <60 kg; 53.67±9.45 kg versus weight >60 kg; 59.9±9.41 kg; P<0.008), age <30 years (younger age 29.36±7.9 years versus older age 35.14±8.02 years; P<0.001), lower hemoglobin value (9.38±2,3 g/dL versus 10.33±2.61 g/dL; P<0.04). By logistic regression analysis, age <30 years (age >30 years; OR=0.12 [CI95% 0.03-04]; P<0.001), female gender (male gender; OR=0.17 [0.04-0.64]; P<0.01), weight <60 kg (weight >60 kg; OR=0.19 [CI95% 0.05-0.72]; P<0.01) were associated with HF. By univariate analysis, when subjects with CRF were compared with those presenting normal GFR, a lower hemoglobin value was significantly associated with CRF (7.92±2.7 g/dL versus 10.43±2.5 g/dL; P<0.009). There was a trend for subjects not being under maintenance therapy to more experience CRF (36.4% versus 70%; P<0.07). By logistic regression analysis, only a low hemoglobin value was associated to CRF (higher hemoglobin level; OR=0.55 [0.20-6.3]; P<0.01). In total, CRF and HF are frequent complications in SCD adult patients from black Africa.
authors.affiliation: Service de néphrologie, hémodialyse et transplantation rénale, CHU de Yopougon, université Félix Houphouët-Boigny, Cocody, BP V 32, Abidjan, Côte d'Ivoire. Electronic address: cnackoundoun66@hotmail.fr.
authors.forename: Clément
authors.initials: C
authors.lastname: Ackoundou-N'Guessan
authors.affiliation: Service de néphrologie, hémodialyse et transplantation rénale, CHU de Yopougon, université Félix Houphouët-Boigny, Cocody, BP V 32, Abidjan, Côte d'Ivoire.
authors.forename: Cyr Monley
authors.initials: CM
authors.lastname: Guei
authors.affiliation: Service de néphrologie, hémodialyse et transplantation rénale, CHU de Yopougon, université Félix Houphouët-Boigny, Cocody, BP V 32, Abidjan, Côte d'Ivoire.
authors.forename: Delphine Amélie
authors.initials: DA
authors.lastname: Lagou
authors.affiliation: Service de néphrologie, hémodialyse et transplantation rénale, CHU de Yopougon, université Félix Houphouët-Boigny, Cocody, BP V 32, Abidjan, Côte d'Ivoire.
authors.forename: Serges
authors.initials: S
authors.lastname: Gbekedi
authors.affiliation: Service de néphrologie, hémodialyse et transplantation rénale, CHU de Yopougon, université Félix Houphouët-Boigny, Cocody, BP V 32, Abidjan, Côte d'Ivoire.
authors.forename: Mélanie Weu
authors.initials: MW
authors.lastname: Tia
authors.affiliation: Service de néphrologie, hémodialyse et transplantation rénale, CHU de Yopougon, université Félix Houphouët-Boigny, Cocody, BP V 32, Abidjan, Côte d'Ivoire.
authors.forename: Pessa Albert
authors.initials: PA
authors.lastname: Coulibaly
authors.affiliation: Service de néphrologie, hémodialyse et transplantation rénale, CHU de Yopougon, université Félix Houphouët-Boigny, Cocody, BP V 32, Abidjan, Côte d'Ivoire.
authors.forename: Sita
authors.initials: S
authors.lastname: Nzoue
authors.affiliation: Service de néphrologie, hémodialyse et transplantation rénale, CHU de Yopougon, université Félix Houphouët-Boigny, Cocody, BP V 32, Abidjan, Côte d'Ivoire.
authors.forename: Serges
authors.initials: S
authors.lastname: Konan
authors.affiliation: Service d'hématologie clinique, CHU de Yopougon, université Félix Houphouët-Boigny, Cocody, BP V 32, Abidjan, Côte d'Ivoire.
authors.forename: Gustave
authors.initials: G
authors.lastname: Koffi
authors.affiliation: Service de néphrologie, hémodialyse et transplantation rénale, CHU de Yopougon, université Félix Houphouët-Boigny, Cocody, BP V 32, Abidjan, Côte d'Ivoire.
authors.forename: Daze Apollinaire
authors.initials: DA
authors.lastname: Gnionsahe
mesh_terms: D000328:Adult; D000349:Africa; D000755:Anemia, Sickle Cell / Q000150:complications*; D044383:Black People; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000209:etiology*; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies
keywords: Afrique noire; Black Africa; Chronic renal failure; Drépanocytose; Glomerular hyperfiltration; Hyperfiltration glomérulaire; Insuffisance rénale chronique; Sickle cell disease