title: [Neural stem cells and Notch signalling].
abstract: Development and repair of the nervous system are based on the existence of neural stem cells (NSCs) able to generate neurons and glial cells. Among the mechanisms that are involved in the control of embryo or adult NSCs, the Notch signalling plays a major role. In embryo, the pathway participates in the maintenance of NSCs during all steps of development of the central nervous system which starts with the production of neurons also called neurogenesis and continues with gliogenesis giving rise to astrocytes and oligodendrocytes. During the postnatal and adult period, Notch signalling is still present in the major neurogenic areas, the subventricular zone of the lateral ventricles and the subgranular zone of the hippocampus. In these regions, Notch maintains NSC quiescence, contributes to the heterogeneity of these cells and displays pleiotropic effects during the regeneration process occurring after a lesion.
authors.affiliation: Inserm, Univ. Paris Sud, Université Paris-Saclay, laboratoire petites molécules de neuroprotection, neurorégénération et remyélinisation, U1195, 80, rue du Général Leclerc, F-94276 Le Kremlin-Bicêtre, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Traiffort
authors.affiliation: Institut de recherches cliniques de Montréal (IRCM), biologie moléculaire du développement neural, 110 Pine Avenue West, Montréal, Québec H2W 1R7, Canada.
authors.forename: Julien
authors.initials: J
authors.lastname: Ferent
mesh_terms: D000367:Age Factors; D000375:Aging; D000818:Animals; D006801:Humans; D009420:Nervous System / Q000254:growth & development; D058953:Neural Stem Cells; D051880:Receptors, Notch / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D051880:Receptors, Notch