title: Pharmacodynamic Study of Interaction of Aqueous Leaf Extract of Psidium Guajava Linn. (Myrtaceae) with Receptor Systems Using Isolated Tissue Preparations.
abstract: The present study investigates the interaction of aqueous leaf extract of Psidium guajava with muscarinic, serotonergic and adrenergic receptor system using isolated rat ileum, gastric fundus and trachea, respectively. The concentration-dependent contractile response of aqueous leaf extract of Psidium guajava was parallel and rightward of standard agonists, ACh and 5-HT indicating agonistic activity on muscarinic and serotonergic receptor systems. The inhibition of aqueous leaf extract of Psidium guajava mediated contractions in presence of atropine (10(-7) M) and ketanserin (10(-6) M) confirmed the activity. Relaxant effect of PG (0.2 mg/ml) on carbachol induced pre-contracted rat tracheal chain indicated its agonistic action on adrenergic receptor system. Inhibition (P<0.05) of the action in the presence of propranolol (1 ng/ml) confirmed the activity. It may be concluded that PG possesses agonistic action on muscarinic, serotonergic and adrenergic receptor systems.
authors.affiliation: Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, New Delhi-110 017, India.
authors.forename: R K
authors.initials: RK
authors.lastname: Mahaseth
authors.affiliation: Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, New Delhi-110 017, India.
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, New Delhi-110 017, India.
authors.forename: Shagun
authors.initials: S
authors.lastname: Dutta
authors.affiliation: Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, New Delhi-110 017, India.
authors.forename: Ratika
authors.initials: R
authors.lastname: Sehgal
authors.affiliation: Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, New Delhi-110 017, India.
authors.forename: Preety
authors.initials: P
authors.lastname: Rajora
authors.affiliation: Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, New Delhi-110 017, India.
authors.forename: Rajani
authors.initials: R
authors.lastname: Mathur
keywords: Psidium guajava; adrenergic receptors; gastric fundus; ileum; muscarinic receptors; serotonergic receptors; tracheal chain