title: Natural history of immediate-type hen's egg allergy in Japanese children.
abstract: BACKGROUND
  Hen's egg (HE) allergy develops during infancy. We investigated tolerance acquisition in Japanese children allergic to HE aging <6 years.
  
  
  METHODS
  In this retrospective study, 226 children born in 2005 with a history of immediate-type HE allergy underwent an oral food challenge (OFC). Tolerance was defined as no reaction to an OFC with half of whole heated HE or accidental HE consumption at home. Participants were divided into three groups based on age at tolerance acquisition: group I (<3 years) (n = 66), group II (3-6 years) (n = 98), and group III (prolonged allergic groups) (n = 62).
  
  
  RESULTS
  Tolerance acquisition occurred in 30% (66/226) by 3 years of age, 59% (133/226) by 5 years of age, and 73% (164/226) at 6 years of age. At 3 years, incidences of allergy-related complications (bronchial asthma, p = 0.02; atopic dermatitis, p = 0.04) were higher in the group III than in the group I. Anaphylaxis to any food occurred more frequently in the group III than in the group I (p = 0.03); anaphylaxis to HE was more common in the group III (p = 0.04). Egg white (EW)- and ovomucoid (OM)-specific immunoglobulin E (IgE) levels were higher in the group III than in the group I (p < 0.05).
  
  
  CONCLUSIONS
  The group III experienced HE-related anaphylaxis and complications more frequently and exhibited sustained, high EW- and OM-specific IgE levels.
authors.affiliation: Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan; Department of Pediatrics, Sagamihara Kyodo Hospital, Kanagawa, Japan.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Ohtani
authors.affiliation: Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan.
authors.forename: Sakura
authors.initials: S
authors.lastname: Sato
authors.affiliation: Futaba Kodomo Clinic, Tokyo, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Syukuya
authors.affiliation: Department of Pediatrics, Sagamihara National Hospital, Kanagawa, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Asaumi
authors.affiliation: Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan.
authors.forename: Kiyotake
authors.initials: K
authors.lastname: Ogura
authors.affiliation: Department of General Medicine, Nagano Children's Hospital, Nagano, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Koike
authors.affiliation: Department of Pediatrics, Sagamihara National Hospital, Kanagawa, Japan.
authors.forename: Katsuhito
authors.initials: K
authors.lastname: Iikura
authors.affiliation: Department of Pediatrics, Sagamihara National Hospital, Kanagawa, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Yanagida
authors.affiliation: Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan; Department of Pediatrics, Showa University, Tokyo, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Imai
authors.affiliation: Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan. Electronic address: m-ebisawa@sagamihara-hosp.gr.jp.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Ebisawa
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D002645:Chickens; D002648:Child; D002675:Child, Preschool; D021181:Egg Hypersensitivity / Q000453:epidemiology* / Q000276:immunology; D004529:Egg White / Q000009:adverse effects; D004531:Eggs / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000485:Allergens; D007073:Immunoglobulin E
keywords: Egg white-specific immunoglobulin E (IgE) antibodies; Hen's egg; Oral food challenge; Ovomucoid-specific IgE; Tolerance acquisition