title: Recent advances in understanding the role of adipocytokines during non-alcoholic fatty liver disease pathogenesis and their link with hepatokines.
abstract: Non-alcoholic fatty liver disease (NAFLD) is currently considered the main cause of chronic liver disease worldwide. Mechanisms leading to the development and progression of this disease are topics of great interest for researchers and clinicians. The current multi-hit hypothesis has thrown the crosstalk between liver and adipose tissue into sharp focus. It is well known that adipose tissue produces circulating factors, known as adipocytokines, which exert several effects on liver cells, promoting the onset of NAFLD and its progression to non-alcoholic steatohepatitis in obese subjects. In a similar way, hepatocytes may also respond to obesogenic stimuli by producing and releasing hepatokines into the circulation. Here, the authors provide an overview of recent advances in our understanding of the role of the most relevant adipocytokines and hepatokines in NAFLD pathogenesis, highlighting their possible molecular and functional interactions.
authors.affiliation: a Liver Research Unit , 'Bambino Gesù' Children's Hospital, IRCCS , Rome , Italy.
authors.forename: Nadia
authors.initials: N
authors.lastname: Panera
authors.affiliation: b Hepato-Metabolic Disease Unit , 'Bambino Gesù' Children's Hospital, IRCCS , Rome , Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Della Corte
authors.affiliation: a Liver Research Unit , 'Bambino Gesù' Children's Hospital, IRCCS , Rome , Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Crudele
authors.affiliation: c Department of Radiobiology and Human Health , ENEA , Rome , Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Stronati
authors.affiliation: b Hepato-Metabolic Disease Unit , 'Bambino Gesù' Children's Hospital, IRCCS , Rome , Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Nobili
authors.affiliation: a Liver Research Unit , 'Bambino Gesù' Children's Hospital, IRCCS , Rome , Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Alisi
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D018450:Disease Progression; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*; D065840:Protective Factors; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D054392:Adipokines; D018836:Inflammation Mediators
keywords: Adipocytokines; FGF21; IL-6; NAFLD; TNF-α; adiponectin; fetuin-A; hepatokines; leptin; resistin