title: Electro-triggering and electrochemical monitoring of dopamine exocytosis from a single cell by using ultrathin electrodes based on Au nanowires.
abstract: A sophisticated set of an Au nanowire (NW) stimulator-Au NW detector system is developed for electrical cell stimulation and electrochemical analysis of subsequent exocytosis with very high spatial resolution. Dopamine release from a rat pheochromocytoma cell is more stimulated by a more negative voltage pulse. This system could help to improve the therapeutic efficacy of electrotherapies by providing valuable information on their healing mechanism.
authors.affiliation: Department of Chemistry, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. bongsoo@kaist.ac.kr.
authors.forename: Mijeong
authors.initials: M
authors.lastname: Kang
authors.affiliation: Department of Chemical and Biomolecular Engineering (BK21 plus Program), KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. leesy@kaist.ac.kr.
authors.forename: Seung Min
authors.initials: SM
authors.lastname: Yoo
authors.affiliation: Department of Chemistry, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. bongsoo@kaist.ac.kr.
authors.forename: Raekeun
authors.initials: R
authors.lastname: Gwak
authors.affiliation: Department of Chemistry, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. bongsoo@kaist.ac.kr.
authors.forename: Gayoung
authors.initials: G
authors.lastname: Eom
authors.affiliation: Department of Chemistry, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. bongsoo@kaist.ac.kr.
authors.forename: Jihwan
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Chemical and Biomolecular Engineering (BK21 plus Program), KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. leesy@kaist.ac.kr.
authors.forename: Sang Yup
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Department of Chemistry, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. bongsoo@kaist.ac.kr.
authors.forename: Bongsoo
authors.initials: B
authors.lastname: Kim
mesh_terms: D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D005089:Exocytosis / Q000502:physiology*; D006046:Gold; D008839:Microelectrodes; D053770:Nanowires; D016716:PC12 Cells; D051381:Rats
chemical_list: D006046:Gold; D004298:Dopamine