title: [Expressions and correlations of Survivin, Ki67 and p53 in laryngeal squmous cell carcinoma].
abstract: OBJECTIVE
  To investigate the expression of Survivin, p53 and Ki67 in laryngeal carcinoma and the relation with clinical data.
  
  
  METHODS
  Immunohistochemical staining (SP) was used to detect expression of Survivin, p53 and Ki67 of 64 cases with laryngeal carcinoma, 26 cases with precancerosis, 34 cases with vocal polyps.
  
  
  RESULTS
  The positive expression rates of Survivin, p53 and Ki67 were 59.4%, 68.8%, 65.6% respectively in laryngeal carcinoma, which were significantly higher than those in precancerosis and vocal polyps (P < 0.01). The expression of Survivin, p53 and Ki67 in laryngeal carcinoma were significantly statistical different in TNM stage and lymph node metastasis (P < 0.05), but were not correlated with patients' ages, the pathological grades, 3 years and 5 years surviving rates (P > 0.05). The expression of Survivin, Ki-67 and p53 was positively correlated (r = 0.607, 0.541, 0.648, P < 0.01) in laryngeal carcinoma.
  
  
  CONCLUSIONS
  Survivin, p53 and Ki-67 may play an important role in the carcinogenesis and progress of laryngeal carcinoma. They may play synergetic roles in the process of carcinogenesis of laryngeal carcinoma.
authors.forename: Jvxiang
authors.initials: J
authors.lastname: Wang
authors.forename: Baoliang
authors.initials: B
authors.lastname: Yang
authors.forename: Shigeng
authors.initials: S
authors.lastname: Pei
authors.forename: Xueling
authors.initials: X
authors.lastname: Wang
authors.forename: Qingjun
authors.initials: Q
authors.lastname: Zhang
authors.forename: Feng
authors.initials: F
authors.lastname: Qu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism*; D007830:Larynx; D008207:Lymphatic Metastasis; D011127:Polyps / Q000378:metabolism; D000077022:Survivin; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D019394:Ki-67 Antigen; D000077022:Survivin; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53