title: The MSHA strain of Pseudomonas aeruginosa (PA-MSHA) inhibits gastric carcinoma progression by inducing M1 macrophage polarization.
abstract: Macrophages play crucial roles in promoting tumor development and progression. In the present study, we found that the mannose-sensitive hemagglutination pilus strain of Pseudomonas aeruginosa (PA-MSHA) was efficient in inducing M1 macrophage polarization. PA-MSHA treatment increases expression of M1-related cytokines and promotes activation of murine peritoneal macrophages (MPM). Interestingly, PA-MSHA inhibits cell proliferation and migration and induces the apoptosis of gastric carcinoma cells. These effects of PA-MSHA on M1 polarization were associated with activation of NF-κB expression. Thus, inducing polarization of M1 by PA-MSHA may be one potential strategy for inhibiting gastric carcinoma progression in mice.
authors.affiliation: Gastrointestinal Surgery Department, Shanghai Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai, 200003, China.
authors.forename: Changming
authors.initials: C
authors.lastname: Wang
authors.affiliation: Gastrointestinal Surgery Department, Shanghai Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai, 200003, China.
authors.forename: Zunqi
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Gastrointestinal Surgery Department, Shanghai Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai, 200003, China.
authors.forename: Zhenxin
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Gastrointestinal Surgery Department, Shanghai Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai, 200003, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Gastrointestinal Surgery Department, Shanghai Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai, 200003, China.
authors.forename: Ziran
authors.initials: Z
authors.lastname: Wei
authors.affiliation: Gastrointestinal Surgery Department, Shanghai Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai, 200003, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Research and Medical Department, Beijing Wanter Bio-pharmaceutical Co., Ltd, Beijing, 101407, China.
authors.forename: Dali
authors.initials: D
authors.lastname: Hu
authors.affiliation: Gastrointestinal Surgery Department, Shanghai Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai, 200003, China. caiqp1969@hotmail.com.
authors.forename: Qingping
authors.initials: Q
authors.lastname: Cai
mesh_terms: D000818:Animals; D017209:Apoptosis; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D016207:Cytokines / Q000096:biosynthesis; D004195:Disease Models, Animal; D018450:Disease Progression; D064593:Heterografts; D008262:Macrophage Activation / Q000276:immunology; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D010587:Phagocytosis; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000502:physiology*; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology*; D013481:Superoxides / Q000378:metabolism; D047368:Tumor Burden; D059016:Tumor Microenvironment / Q000276:immunology
chemical_list: D016207:Cytokines; D016328:NF-kappa B; D009573:Nitrites; D013481:Superoxides
keywords: Gastric carcinoma; M1 polarization; NF-κB; PA-MSHA