title: [Research progress on the clinical value of Ki-67 in breast cancer and its cut-off definition].
abstract: Ki-67 has an important application value in clinical practice. However, it is still a little tough in clinical application because of the debate on the cut-off definition of Ki-67 index. This review summarizes most studies on the prognostic and predictive value of Ki-67, analyzes the reasons for the discrepancies among the studies cited, and presents the necessity and clinical significance of scientifically defining the cut-off of Ki-67 index, providing a theoretical basis for Ki-67 in clinical application.
authors.affiliation: Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China; Email: kejinwu@163.com.
authors.forename: Kejin
authors.initials: K
authors.lastname: Wu
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis*; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D011379:Prognosis
chemical_list: D019394:Ki-67 Antigen