title: Toxicological evaluation of Yulangsan polysaccharide in Wistar rats: A 26-week oral gavage study.
abstract: Although numerous studies have proven the medicinal values of Yulangsan polysaccharide (YLSP), the toxicity of this active ingredient is unknown. In the acute toxicity study, a single oral administration of 24 g/kg YLSP caused neither toxicological symptoms nor mortality, and the LD50 was estimated >24 g/kg. In the chronic toxicity study, we administered doses of 0, 0.6, 1.2 and 2.4 g/kg YLSP in rats by oral gavage for 26 weeks followed by a 3-week recovery period. There was no mortality or remarkable clinical signs observed during this 26-week study. Additionally, there were no toxic differences in the following parameters: body weight, food consumption, hematology, clinical biochemistry, organ weight, and macroscopic ﬁndings. There were no adverse effects on histopathology observed in males or female rats treated with YLSP. Based on the results, the no-observed-adverse-effect-level of YLSP in rats is greater than 2.4 g/kg when administered orally for 26 consecutive weeks.
authors.affiliation: Department of Pharmacology, Guangxi Medical University, Nanning, Guangxi, 530021, PR China; Department of Hyperbaric Oxygen, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, PR China.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Pharmacology, Guangxi Medical University, Nanning, Guangxi, 530021, PR China.
authors.forename: Zhihuan
authors.initials: Z
authors.lastname: Nong
authors.affiliation: Department of Pharmacology, Guangxi Medical University, Nanning, Guangxi, 530021, PR China.
authors.forename: Mingyu
authors.initials: M
authors.lastname: Meng
authors.affiliation: Department of Pharmacology, Guangxi Medical University, Nanning, Guangxi, 530021, PR China.
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Wen
authors.affiliation: Department of Pharmacology, Guangxi Medical University, Nanning, Guangxi, 530021, PR China.
authors.forename: Xing
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Pharmacology, Guangxi Medical University, Nanning, Guangxi, 530021, PR China.
authors.forename: Feizhang
authors.initials: F
authors.lastname: Qin
authors.affiliation: Department of Pharmacology, Guangxi Medical University, Nanning, Guangxi, 530021, PR China.
authors.forename: Jianchun
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Pharmacology, Guangxi Medical University, Nanning, Guangxi, 530021, PR China. Electronic address: huangrenbin518@163.com.
authors.forename: Renbin
authors.initials: R
authors.lastname: Huang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D011134:Polysaccharides / Q000008:administration & dosage* / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D011134:Polysaccharides
keywords: Toxicological evaluation; Wistar rats; Yulangsan polysaccharide