title: Copper-Catalyzed Domino Synthesis of 2-Arylthiochromanones through Concomitant C-S Bond Formations Using Xanthate as Sulfur Source.
abstract: An efficient domino process for the synthesis of thioflavanones has been described using a copper catalyst without addition of any external ligand. A variety of thioflavanones have been synthesized from easily accessible 2'-iodochalcones or 2'-bromochalcones in excellent yield through in situ incorporation of sulfur using xanthate as an odorless sulfur source. This domino process proceeds through Cu-catalyzed C(aryl)-S bond formation by the coupling reaction of xanthate with 2'-halochalcones followed by C-S bond cleavage of thioester then S-C bond formation by intramolecular Michael addition.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras , Chennai 600036, Tamil Nadu, India.
authors.forename: Subramani
authors.initials: S
authors.lastname: Sangeetha
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras , Chennai 600036, Tamil Nadu, India.
authors.forename: Pandi
authors.initials: P
authors.lastname: Muthupandi
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras , Chennai 600036, Tamil Nadu, India.
authors.forename: Govindasamy
authors.initials: G
authors.lastname: Sekar