title: Daylight photodynamic therapy with 1.5% 3-butenyl 5-aminolevulinate gel as a convenient, effective and safe therapy in acne treatment: A double-blind randomized controlled trial.
abstract: While daylight photodynamic therapy (PDT) is a simpler and more tolerable treatment procedure for both clinicians and patients, it has never been applied for acne treatment. In this study, we evaluated efficacy, safety and histological changes of facial acne after application of the novel variant of 5-aminolevulinate (ALA)-ester, 1.5% 3-butenyl ALA-bu gel, using daylight only as the potential visible light source. Forty-six acne patients were randomly assigned to either ALA-bu or vehicle application group in a double-blind fashion. Both groups applied the allocated gel to facial acne lesions every other day for 12 weeks. At the final 12 week, both inflammatory and non-inflammatory acne lesions had decreased significantly by 58.0% and 34.1% in the ALA-bu group, respectively. Only a few patients expressed mild adverse effects. In the histopathological analysis, attenuated inflammatory cell infiltrations were observed and immunostaining intensities for interleukin-8, interleukin-1β, matrix metalloproteinase-9 and phosphorylated nuclear factor-κB were reduced concomitantly. Changes of their mRNA expression demonstrated comparable patterns. In conclusion, this ambulatory PDT was effective, very well tolerated and convenient for treating inflammatory acne lesions. Experimental results correlated well with clinical results. This novel regimen would provide a viable option for acne therapy.
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.|Acne Research Laboratory, Seoul National University Hospital, Seoul, Korea.
authors.forename: Hyuck Hoon
authors.initials: HH
authors.lastname: Kwon
authors.affiliation: Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Ki Rang
authors.initials: KR
authors.lastname: Moon
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.|Acne Research Laboratory, Seoul National University Hospital, Seoul, Korea.
authors.forename: Seon Yong
authors.initials: SY
authors.lastname: Park
authors.affiliation: Acne Research Laboratory, Seoul National University Hospital, Seoul, Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Yoon
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.|Acne Research Laboratory, Seoul National University Hospital, Seoul, Korea.
authors.forename: Dae Hun
authors.initials: DH
authors.lastname: Suh
authors.affiliation: Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Jee Bum
authors.initials: JB
authors.lastname: Lee
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000328:Adult; D000622:Aminolevulinic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004311:Double-Blind Method; D004952:Esters / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005145:Face; D005260:Female; D005782:Gels; D006801:Humans; D053583:Interleukin-1beta / Q000378:metabolism; D016209:Interleukin-8 / Q000276:immunology; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D010778:Photochemotherapy / Q000009:adverse effects / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D012333:RNA, Messenger / Q000378:metabolism; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: C508606:CXCL8 protein, human; D004952:Esters; D005782:Gels; C508585:IL1B protein, human; D053583:Interleukin-1beta; D016209:Interleukin-8; D016328:NF-kappa B; D017319:Photosensitizing Agents; D012333:RNA, Messenger; D000622:Aminolevulinic Acid; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
keywords: acne; photodynamic therapy; phototherapy