title: Distal bile duct carcinomas and pancreatic ductal adenocarcinomas: postulating a common tumor entity.
abstract: The set definition of distal cholangiocarcinomas and adenocarcinomas of the pancreatic head is challenged by their close anatomical relation, similar growth pattern, and corresponding therapeutic outcome. They show a mutual development during embryologic organ formation and share phenotypic characteristics. This review will highlight the similarities with regard to the common origin of their primary organs, histopathological similarities, and modern clinical management. Thus, we propose to subsume those entities under a common superfamily.
authors.affiliation: General, Visceral and Transplantation Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Rosa B
authors.initials: RB
authors.lastname: Schmuck
authors.affiliation: General, Visceral and Transplantation Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Cynthia V
authors.initials: CV
authors.lastname: de Carvalho-Fischer
authors.affiliation: General, Visceral and Transplantation Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Christopher
authors.initials: C
authors.lastname: Neumann
authors.affiliation: General, Visceral and Transplantation Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Johann
authors.initials: J
authors.lastname: Pratschke
authors.affiliation: General, Visceral and Transplantation Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Bahra
mesh_terms: D000818:Animals; D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000628:therapy; D017734:Bile Ducts, Extrahepatic / Q000196:embryology / Q000473:pathology*; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D003952:Diagnostic Imaging; D014644:Genetic Variation; D006801:Humans; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000628:therapy; D010641:Phenotype
keywords: Bile duct neoplasm; cholangiocarcinoma; pancreatic neoplasm