title: Acute reduction in blood pressure following consumption of anthocyanin-rich cherry juice may be dose-interval dependant: a pilot cross-over study.
abstract: A pilot cross-over study assessed the acute effects on blood pressure and plasma biomarkers associated with consumption of a 300 ml anthocyanin-rich fruit juice, provided in differing dose-intervals. Young adults (n = 6) and older adults (n = 7) received in random order, either a single 300 ml dose or 3 × 100 ml doses of high-flavonoid cherry juice provided at 0, 1 and 2 h. Blood pressure and plasma levels of phenolic metabolites were measured at 0, 2 and 6 h.The single 300 ml dose of cherry juice resulted in a significant reduction in systolic (p = 0.002), and diastolic blood pressure (p = 0.008) and heart-rate (p = 0.033) 2 h after consumption, before returning to baseline levels at 6 h post-consumption. The 3 × 100 ml dose provided over 2 h did not result in significant blood pressure reductions. Plasma phenolic metabolites increased at 2 and 6 h; however, fluctuations were higher after the single 300 ml dose in older adults. These findings have implications for design of intervention studies that investigate vascular effects associated with flavonoid-rich foods.
authors.affiliation: a Faculty of Science, Medicine and Health, School of Medicine , University of Wollongong , Wollongong , Australia ;
authors.forename: Katherine
authors.initials: K
authors.lastname: Kent
authors.affiliation: a Faculty of Science, Medicine and Health, School of Medicine , University of Wollongong , Wollongong , Australia ;
authors.forename: Karen E
authors.initials: KE
authors.lastname: Charlton
authors.affiliation: b Illawarra Health and Medical Research Institute , University of Wollongong , Wollongong , Australia ;
authors.forename: Andrew
authors.initials: A
authors.lastname: Jenner
authors.affiliation: c Faculty of Social Sciences , School of Psychology, University of Wollongong , Wollongong , Australia.
authors.forename: Steven
authors.initials: S
authors.lastname: Roodenrys
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000872:Anthocyanins / Q000008:administration & dosage* / Q000494:pharmacology; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects*; D018592:Cross-Over Studies; D005419:Flavonoids / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D000067030:Fruit and Vegetable Juices; D006801:Humans; D006973:Hypertension; D010636:Phenols / Q000097:blood*; D010865:Pilot Projects; D010936:Plant Extracts / Q000008:administration & dosage* / Q000494:pharmacology; D027861:Prunus / Q000737:chemistry*; D055815:Young Adult
chemical_list: D000872:Anthocyanins; D015415:Biomarkers; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts
keywords: Acute; anthocyanins; blood pressure; cherry juice; cross-over; dose