title: β-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis.
abstract: BACKGROUND
  Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases with serious impact on quality of life. β-Glucans are natural substances with potent immunomodulatory and anti-inflammatory activity.
  
  
  METHODS
  In a multicentre open split-body study, we studied the effect of Imunoglukan P4H® cream in a group of 105 patients with AD (39 males, 37%). Evaluation of subjective (visual analogue scale, VAS) and objective (EASI score, eczema area and severity index) characteristics of AD was carried out.
  
  
  RESULTS
  In total, 80 patients (76.2%) completed the study. Topical β-glucan application resulted in the significant improvement of both objective and subjective symptoms of AD. On the application side, significant decline in the number of days with AD exacerbation and its severity was observed. Moreover, the subjects experienced decline of pruritus on the β-glucan half of the body (VAS score: 1.68 vs. 1.95, p < 0.001). During the study, the continual and significant decline of EASI scores on the site of β-glucan application was observed (V4: 1.57 vs. 1.85, p < 0.001). The preparation was in general well tolerated.
  
  
  CONCLUSIONS
  This is the first study evaluating and confirming the potential use of β-glucan-based cream as a supportive complementary therapy of atopic dermatitis.
authors.affiliation: a Department of Paediatrics, Jessenius Faculty of Medicine , Comenius University in Bratislava , Martin , Slovakia .
authors.forename: Milos
authors.initials: M
authors.lastname: Jesenak
authors.affiliation: b Department of Dermatology , Slovak Medical University , Banska Bystrica , Slovakia .
authors.forename: Slavomir
authors.initials: S
authors.lastname: Urbancek
authors.affiliation: c Department of Microbiology, Faculty of Medicine , Slovak Medical University , Bratislava , Slovakia .|d Institute of Zoology, Slovak Academy of Sciences , Bratislava , Slovakia , and.
authors.forename: Juraj
authors.initials: J
authors.lastname: Majtan
authors.affiliation: a Department of Paediatrics, Jessenius Faculty of Medicine , Comenius University in Bratislava , Martin , Slovakia .
authors.forename: Peter
authors.initials: P
authors.lastname: Banovcin
authors.affiliation: e Department of Dermatovenerology , Second School of Medicine, Bulovka University Hospital, Charles University , Prague , Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Hercogova
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D004643:Emollients / Q000737:chemistry / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage*; D020076:Pleurotus; D011788:Quality of Life; D016896:Treatment Outcome; D055815:Young Adult; D047071:beta-Glucans / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D004643:Emollients; D010936:Plant Extracts; D047071:beta-Glucans
keywords: atopic dermatitis; complementary medicine; pleuran; topical treatment; β-glucan