title: The Value of Tranexamic Acid in Reducing Blood Loss following Hip Reconstruction in Children with Cerebral Palsy.
abstract: This is a retrospective study of 51 consecutive hip reconstructions in children with cerebral palsy performed between 2011 and 2013. Tranexamic acid (TXA) was used in 14 hip reconstructions only. Transfusion rate was higher, postoperative Hb was lower, and patients stayed longer in the TXA group. This did not reach a statistical significance (P = 0.75, 0.5, and 0.71, resp.). More than half of the patients who had TXA underwent bilateral hip reconstructions in comparison with 27% only in the non-TXA group. Bilateral hip reconstructions mean more surgery, more blood loss, and more blood transfusion. The patients who had TXA were significantly more disabled as evident by the higher proportions of patient with worse GMFCS levels. Although we have not been able to demonstrate the value of TXA in reducing blood loss and transfusion rate in children with CP who underwent hip reconstruction, it is hoped that an interest in exploring the value of TXA in paediatric orthopaedic surgery is generated. Ideally this should be explored further in an adequately powered, randomised controlled trial where risk of bias is minimized.
authors.affiliation: Royal Manchester Children Hospital, Central Manchester University Hospitals, Oxford Road, Manchester M13 9WL, UK.
authors.forename: I
authors.initials: I
authors.lastname: Majid
authors.affiliation: Royal Manchester Children Hospital, Central Manchester University Hospitals, Oxford Road, Manchester M13 9WL, UK.
authors.forename: S
authors.initials: S
authors.lastname: Alshryda
authors.affiliation: Royal Manchester Children Hospital, Central Manchester University Hospitals, Oxford Road, Manchester M13 9WL, UK.
authors.forename: B
authors.initials: B
authors.lastname: Somanchi
authors.affiliation: Royal Manchester Children Hospital, Central Manchester University Hospitals, Oxford Road, Manchester M13 9WL, UK.
authors.forename: E
authors.initials: E
authors.lastname: Morakis
authors.affiliation: Royal Manchester Children Hospital, Central Manchester University Hospitals, Oxford Road, Manchester M13 9WL, UK.
authors.forename: A
authors.initials: A
authors.lastname: Foster