title: Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces.
abstract: Perivascular spaces are an emerging marker of small vessel disease. Perivascular spaces in the centrum semiovale have been associated with cerebral amyloid angiopathy. However, a direct topographical relationship between dilated perivascular spaces and cerebral amyloid angiopathy severity has not been established. We examined this association using post-mortem magnetic resonance imaging in five cases with evidence of cerebral amyloid angiopathy pathology. Juxtacortical perivascular spaces dilation was evaluated on T2 images and related to cerebral amyloid angiopathy severity in overlying cortical areas on 34 tissue sections stained for Amyloid β. Degree of perivascular spaces dilation was significantly associated with cerebral amyloid angiopathy severity (odds ratio = 3.3, 95% confidence interval 1.3-7.9, p = 0.011). Thus, dilated juxtacortical perivascular spaces are a promising neuroimaging marker of cerebral amyloid angiopathy severity.
authors.affiliation: Department of Neurology, Brain Center Rudolf Magnus, UMC Utrecht, the Netherlands J.P.K. Stroke Research Center, Department of Neurology, MGH, Boston, MA, USA s.j.veluw-2@umcutrecht.nl.
authors.forename: Susanne J
authors.initials: SJ
authors.lastname: van Veluw
authors.affiliation: Department of Neurology, Brain Center Rudolf Magnus, UMC Utrecht, the Netherlands.
authors.forename: Geert Jan
authors.initials: GJ
authors.lastname: Biessels
authors.affiliation: Department of Neurology, Brain Center Rudolf Magnus, UMC Utrecht, the Netherlands.
authors.forename: Willem H
authors.initials: WH
authors.lastname: Bouvy
authors.affiliation: Department of Pathology, UMC Utrecht, the Netherlands.
authors.forename: Wim Gm
authors.initials: WG
authors.lastname: Spliet
authors.affiliation: Department of Radiology, UMC Utrecht, the Netherlands.
authors.forename: Jaco Jm
authors.initials: JJ
authors.lastname: Zwanenburg
authors.affiliation: Department of Radiology, UMC Utrecht, the Netherlands.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Luijten
authors.affiliation: Biostatistics Center, MGH and Harvard Medical School, Boston, MA, USA.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Macklin
authors.affiliation: Department of Pathology, UMC Utrecht, the Netherlands.
authors.forename: Annemieke Jm
authors.initials: AJ
authors.lastname: Rozemuller
authors.affiliation: J.P.K. Stroke Research Center, Department of Neurology, MGH, Boston, MA, USA.
authors.forename: M Edip
authors.initials: ME
authors.lastname: Gurol
authors.affiliation: J.P.K. Stroke Research Center, Department of Neurology, MGH, Boston, MA, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Greenberg
authors.affiliation: J.P.K. Stroke Research Center, Department of Neurology, MGH, Boston, MA, USA.
authors.forename: Anand
authors.initials: A
authors.lastname: Viswanathan
authors.affiliation: J.P.K. Stroke Research Center, Department of Neurology, MGH, Boston, MA, USA.
authors.forename: Sergi
authors.initials: S
authors.lastname: Martinez-Ramirez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000032:analysis*; D016657:Cerebral Amyloid Angiopathy / Q000473:pathology*; D002540:Cerebral Cortex / Q000098:blood supply* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male
chemical_list: D016229:Amyloid beta-Peptides
keywords: 7 T magnetic resonance imaging; amyloid angiopathy; histology; microbleeds; perivascular spaces