title: Is obesity associated with healing after non-surgical periodontal therapy? A local vs. systemic evaluation.
abstract: BACKGROUND
  We aimed to detect the role of obesity on the healing response to periodontal therapy in terms of serum lipids, C-reactive protein (CRP) and both serum and gingival crevicular fluid adipocytokines.
  
  
  METHODS
  Thirty patients with periodontitis with (CPO) (n = 15) and without (n = 15) obesity and 15 healthy controls were included. Serum high-density lipoprotein, low-density lipoprotein, triglyceride, CRP levels and levels of adiponectin, interleukin (IL)-6, tumor necrosis factor (TNF)-α and IL-10 were evaluated before and 3 mo after initial periodontal therapy. Clinical periodontal measurements were also recorded at baseline and 3 mo.
  
  
  RESULTS
  Periodontal parameters improved significantly in both periodontitis groups with or without obesity (p < 0.05) with no significant difference in terms of gain clinical attachment level (p > 0.05) and change in numbers of sites with probing depth ≥ 4 mm. High-density lipoprotein significantly increased in both groups (p > 0.05). CRP decreased significantly solely in the normal weight group. IL-6, IL-10 and TNF-α levels in gingival crevicular fluid improved significantly based on therapy in both groups (p < 0.05). Only TNF-α decreased significantly in the CPO, while adiponectin and IL-10 in addition to TNF-α improved significantly in the group of patients with periodontitis without obesity.
  
  
  CONCLUSIONS
  Patients with CPO respond to periodontal therapy as well as the non-obese controls. This similar response is accompanied with consistent adipokine levels in gingival crevicular fluid. However, obesity affects the CRP and serum adipocytokine levels in response to therapy.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Duzagac
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Cifcibasi
authors.affiliation: Department of Internal Medicine, Hamur State Hospital, Agri, Turkey.
authors.forename: M G
authors.initials: MG
authors.lastname: Erdem
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
authors.forename: V
authors.initials: V
authors.lastname: Karabey
authors.affiliation: Department of Microbiology and Clinical Microbiology, Virology and Fundamental Immunology Unit, School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Kasali
authors.affiliation: Department of Biostatistics, School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Badur
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Cintan
mesh_terms: D054392:Adipokines / Q000032:analysis*; D052242:Adiponectin / Q000032:analysis; D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D016207:Cytokines / Q000032:analysis; D003774:Dental Plaque Index; D012534:Dental Scaling; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D016753:Interleukin-10 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D017622:Periodontal Attachment Loss / Q000628:therapy; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000628:therapy; D010518:Periodontitis / Q000628:therapy*; D016745:Root Planing; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D016207:Cytokines; C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D002097:C-Reactive Protein
keywords: chronic periodontitis; cytokines; gingival crevice fluid; obesity; periodontal therapy; systemic host effect