title: [Perception of pT1a,b pN0 breast tumor prognosis by the French oncology community: Results of the EURISTIC national survey].
abstract: The prognosis of infracentimetric breast cancers (BC) is heterogeneous. The EURISTIC survey describes how French oncology specialists perceive the prognosis of pT1a,b pN0 BCs. A self-administered questionnaire has been sent to over 2000 French BC specialists. Six hundred and sixty-three physicians responded. Fifty-eight percent do not consider tumor size as a key prognostic criterion. They consider that the cutoff for poor prognosis is 22mm, 10mm and 7mm for hormone receptors (HRs)+, HER2+ and triple-negative (TN) tumors respectively. Eighty-three percent of respondents consider that a HR+ pT1a,b tumor has a good prognosis (21% and 8% for HER2+ and TN respectively). Factors perceived as most detrimental are: HER2 overexpression (29% of respondents); HR- (20%); high grade (20%); TN status (14%); high KI67 (5%); presence of lymphovascular invasion (3%); young age (2%) and high mitotic index (1%). For French specialists, immunohistochemical characteristics, in particular hormone and HER2 status, are strong prognostic factors in BCs below 1cm.
authors.affiliation: Institut Gustave-Roussy, department of medical oncology, 114, rue Édouard-Vaillant, 94805 Villejuif cedex, France. Electronic address: marc.spielmann@igr.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: Spielmann
authors.affiliation: Institut Claudius-Regaud, department of medical oncology, 20-24, rue du Pont-Saint-Pierre, 31052 Toulouse, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Dalenc
authors.affiliation: Centre Jean-Bernard, clinique Victor-Hugo, department of radiation oncology, 18, rue Victor-Hugo, 72000 Le Mans, France; Centre hospitalier régional universitaire, department of radiation oncology, 37044 Tours cedex 9, France.
authors.forename: Yoann
authors.initials: Y
authors.lastname: Pointreau
authors.affiliation: ICM centre Val-d'Aurelle, department of radiation oncology, 208, avenue des Apothicaires, parc Euromédecine, 34298 Montpellier cedex 5, France.
authors.forename: David
authors.initials: D
authors.lastname: Azria
authors.affiliation: Site hospitalier Nord, centre René-Gauducheau, department of surgery, boulevard Jacques-Monod, 44805 Saint-Herblain cedex, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Classe
authors.affiliation: Institut Gustave-Roussy, department of medical oncology, 114, rue Édouard-Vaillant, 94805 Villejuif cedex, France.
authors.forename: Clarisse
authors.initials: C
authors.lastname: Dromain
authors.affiliation: Clinique Courlancy, department of medical oncology, 38, rue de Courlancy, 51100 Reims, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Facchini
authors.affiliation: Institut Paoli-Calmettes, department of medical oncology, 232, boulevard de Sainte-Marguerite, 13009 Marseille, France.
authors.forename: Anthony
authors.initials: A
authors.lastname: Gonçalves
authors.affiliation: Institut du sein de l'Orangerie, department of surgery, 11, rue Silbermann, 67000 Strasbourg, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Liegeois
authors.affiliation: Clinique Saint-Georges, department of medical oncology, 2, avenue de Rimiez, 06100 Nice cedex 2, France.
authors.forename: Moïse
authors.initials: M
authors.lastname: Namer
authors.affiliation: Centre hospitalier universitaire, department of medical oncology, 2, place Saint-Jacques, 25000 Besançon, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Pivot
authors.affiliation: Institut Curie, department of pathology, 26, rue d'Ulm, 75248 Paris cedex 05, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Vincent-Salomon
mesh_terms: D000367:Age Factors; D001943:Breast Neoplasms / Q000737:chemistry / Q000276:immunology / Q000473:pathology* / Q000523:psychology*; D004617:Embolism / Q000150:complications; D005260:Female; D005602:France; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008495:Medical Oncology / Q000706:statistics & numerical data; D008940:Mitotic Index; D010465:Perception; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011795:Surveys and Questionnaires; D064726:Triple Negative Breast Neoplasms; D047368:Tumor Burden
chemical_list: D019394:Ki-67 Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen
keywords: Breast cancer; Cancer du sein; PT1a/b pN0; Prognosis; Pronostic