title: Splenic Artery Embolization in Patients After Orthotopic Liver Transplant.
abstract: OBJECTIVE
  Hypersplenism (thrombocytopenia, leukopenia, anemia) syndrome and ascites occur after orthotopic liver transplant. These conditions can be treated by open splenectomy. Splenic artery embolization has been practiced as an alternative surgical method.
  
  
  METHODS
  Between January 2013 and January 2015, twenty-one orthotopic liver transplants were performed at the National Scientific Medical Research Center, Astana, Kazakhstan. Of these patients, 3 subsequently received splenic artery embolization 12, 8, and 6 months after transplant: 2 patients who had been diagnosed with primary biliary cirrhosis and 1 patient with hepatitis B virus -related liver cirrhosis. Two patients received a right-lobe living orthotopic liver transplant, and 1 patient received a deceased donor transplant. Indications for splenic artery embolization (ascites, splenomegaly) were based on clinical and ultrasonographic investigation and laboratory findings (thrombocytopenia, platelet count < 60 × 109/L, leukocytopenia, and white blood cell count < 2 × 109/L). Two recipients had leukothrombocytopenia and refractory ascites, and 1 had only thrombocytopenia. Splenic artery embolization was performed via a percutaneous femoral artery approach under local anesthesia. Transcatheter splenic artery branch occlusion was performed by deploying occlusion material. Preoperative spleen size ranged from 17.5 × 8.0 cm to 22.0 × 12.5 cm; ascites volumes were > 1000 mL.
  
  
  RESULTS
  In all patients, ascites and platelet levels decreased after splenic artery embolization. In 1 patient with leukopenia, white blood cell count normalized. After embolization, 1 patient had severe abdominal pain requiring analgesia medication, and 2 patients had fever that lasted 3 days. Patients were discharged 6 to 9 days after embolization. One patient developed a perisplenic abscess without fever 1 month after discharge, and the abscess was drained using an ultrasound-guided percutaneous procedure.
  
  
  CONCLUSIONS
  Splenic artery embolization is a safe and effective minimally invasive method for treating hypersplenism and ascites in orthotopic liver transplant recipients and an alternative to open splenectomy.
authors.affiliation: From the JSC National Scientific Medical Research Center, Astana, Kazakhstan.
authors.forename: Myltykbay
authors.initials: M
authors.lastname: Rysmakhanov
authors.forename: Marlen
authors.initials: M
authors.lastname: Doskali
authors.forename: Aliya
authors.initials: A
authors.lastname: Taganova
authors.forename: Aidos
authors.initials: A
authors.lastname: Kulmagambetov
authors.forename: Aibolat
authors.initials: A
authors.lastname: Smagulov
authors.forename: Akhmet
authors.initials: A
authors.lastname: Seidakhmetov
authors.forename: Abay
authors.initials: A
authors.lastname: Baigenzhin
authors.forename: Zhaksylyk
authors.initials: Z
authors.lastname: Doskaliyev
mesh_terms: D001201:Ascites / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D006971:Hypersplenism / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D007623:Kazakhstan; D016031:Liver Transplantation / Q000009:adverse effects*; D012307:Risk Factors; D013157:Splenic Artery; D013577:Syndrome; D016896:Treatment Outcome