title: Quantitative assessment of cerebral gray matter density change in progressive supranuclear palsy using voxel based morphometry analysis and cerebral MR T1-weighted FLAIR imaging.
abstract: OBJECTIVE
  To investigate the gray matter (GM) atrophy in Progressive supranuclear palsy (PSP) using T1-weighted Fluid-Attenuated Inversion Recovery (FLAIR) images based on voxel based morphometry (VBM) method.
  
  
  METHODS
  In this study, we firstly modified the conventional VBM method to make it can process the T1-weighted FLAIR brain images. Then, we used this method on the 24 PSP patients and 23 healthy age- and sex-matched control subjects to find the local gray matter density changes of PSP patients.
  
  
  RESULTS
  Compared with healthy controls, GM reductions of PSP patients mainly located in the thalamus, basal ganglia, pons, midbrain, insular cortex, frontal cortex, temporal lobe, cerebellum, cingulate cortex and hippocampus.
  
  
  CONCLUSIONS
  We used the modified VBM technique into T1 FLAIR data to study the brain gray matter atrophy in PSP, and found some new atrophy areas, including pallidum, middle and posterior cingulum, lingual, fusiform gyrus and the post part of inferior temporal gyrus. These areas have not been described in the former VBM studies, but they revealed abnormity in the pathologic and other studies on PSP. Our results might be expected to provide significant underlining neurology information and diagnostic value for PSP.
authors.affiliation: Center for Neurodegenerative Diseases, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantan Xili, Dongcheng District, Beijing 100050, China.
authors.forename: Guihong
authors.initials: G
authors.lastname: Wang
authors.affiliation: Division of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing 100049, China.
authors.forename: Jingjuan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Neuroscience Imaging Center, Beijing Tiantan Hospital, 6 Tiantan Xili, Dongcheng District, Beijing 100050, China.
authors.forename: Jiong
authors.initials: J
authors.lastname: Zhan
authors.affiliation: Division of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing 100049, China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Nie
authors.affiliation: Division of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing 100049, China; Physical Science and Technology College, Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Panlong
authors.initials: P
authors.lastname: Li
authors.affiliation: Division of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing 100049, China; Physical Science and Technology College, Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Lidan
authors.initials: L
authors.lastname: Fan
authors.affiliation: Division of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing 100049, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Center for Neurodegenerative Diseases, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantan Xili, Dongcheng District, Beijing 100050, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Parkinson's Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China. Electronic address: happyft@sina.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.affiliation: Division of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing 100049, China. Electronic address: shanbc@ihep.ac.cn.
authors.forename: Baoci
authors.initials: B
authors.lastname: Shan
mesh_terms: D000368:Aged; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013494:Supranuclear Palsy, Progressive / Q000473:pathology*
keywords: Gray matter atrophy; MRI; PSP; Quantitative assessment; T1-weighted FLAIR imaging; VBM