title: Short treatment time and excellent treatment outcome in accelerated hyperfractionated radiotherapy for T1 glottic cancer.
abstract: Accelerated hyperfractionated radiotherapy was performed as treatment for patients with T1 glottic cancer, and its utility was evaluated based on treatment outcomes and adverse effects. Fifty-eight men who had undergone radiotherapy were retrospectively reviewed. Tumor classification was Tis in 4 patients, T1a in 38, and T1b in 16. Histological examination revealed squamous cell carcinoma in 55 patients. Travel time from home to hospital was 0-1 hour for 24 patients, 1-2 hours for 9, and >2 hours for 25. Laser vaporization was performed prior to radiotherapy in 38 patients, and 19 patients received concurrent chemotherapy with an agent such as S-1. Patients were irradiated twice daily using an irradiation container. Most patients received a dose of 1.5 Gy/fraction up to a total of 60 Gy. The median overall treatment time was 30 days, with a median observation period of 59.6 months. A complete response was observed in all patients. The 5-year overall survival, disease-free survival, and local control rates were 97.2%, 93.2%, and 97.8%, respectively. Although grade 3 pharyngeal mucositis was observed in 2 patients, there were no other grade 3 or higher acute adverse events. As late toxicity, grade 2 laryngeal edema and grade 1 laryngeal hemorrhage were observed in 1 patient each, but no serious events such as laryngeal necrosis or laryngeal stenosis were observed. In conclusion, this treatment method brings excellent outcome and will substantially reduce the treatment duration among patients who need to stay at nearby hotels while undergoing treatment at hospitals in rural areas.
authors.affiliation: Department of Radiation Oncology, Shimane University School of Medicine, Izumo, Japan.
authors.forename: Yukihisa
authors.initials: Y
authors.lastname: Tamaki
authors.affiliation: Department of Radiation Oncology, Shimane University School of Medicine, Izumo, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Hieda
authors.affiliation: Department of Radiology, Shimane University School of Medicine, Izumo, Japan.
authors.forename: Rika
authors.initials: R
authors.lastname: Yoshida
authors.affiliation: Department of Radiology, Shimane University School of Medicine, Izumo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshizako
authors.affiliation: Department of Otorhinolaryngology, Shimane University School of Medicine, Izumo, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Fuchiwaki
authors.affiliation: Department of Otorhinolaryngology, Shimane University School of Medicine, Izumo, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Aoi
authors.affiliation: Department of Genetics, Radiation Effects Research Foundation, Hiroshima, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Sekihara
authors.affiliation: Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kitajima
authors.affiliation: Department of Otorhinolaryngology, Shimane University School of Medicine, Izumo, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kawauchi
authors.affiliation: Department of Radiology, Shimane University School of Medicine, Izumo, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Kitagaki
authors.affiliation: Department of Radiation Oncology, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Sasaki
authors.affiliation: Department of Radiation Oncology, Shimane University School of Medicine, Izumo, Japan.
authors.forename: Taisuke
authors.initials: T
authors.lastname: Inomata
keywords: accelerated hyperftactionted radiotherapy; glottic cancer; local control rate; overall treatment time; safety