title: [Association of ADAMTS-1 gene polymorphisms with ischemic stroke caused by large artery atherosclerosis].
abstract: OBJECTIVE
  To assess the association of a disintegrin and metallo-proteinase with thrombospondin type 1 motifs (ADAMTS-1) gene polymorphism and ischemic stroke caused by large artery atherosclerosis (LAA).
  
  
  METHODS
  In total 767 patients and 506 controls were recruited. Single nucleotide polymorphisms (SNPs) rs416905 (T/C) and rs402007 (G/C) of the ADAMTS-1 gene were genotyped by polymerase chain reaction and DNA sequencing.
  
  
  RESULTS
  Frequencies of the rs402007 GC+CC genotype and the C allele were significantly different between the two groups (68.84% vs. 60.67%, χ2=9.012, P=0.003, OR=1.432; 45.24% vs. 38.54%, χ2=11.208, P=0.001, OR=1.318). Binary logistic regression has confirmed that the above difference was significant (P=0.001, OR=1.521, 95%CI: 1.183-1.955). The frequencies of TC+CC and GC+CC genotypes were similar between the two groups, and so was it with the C allele. The two SNPs had been in complete linkage disequilibrium (D'=1.0, r2=1.0).
  
  
  CONCLUSIONS
  The rs416905 and rs402007 polymorphisms of the ADAMTS-1 gene may be associated with ischemic stroke caused by LAA. The C allele of the rs402007 locus may be a susceptibility factor for this subtype of stroke.
authors.affiliation: Department of Neurology, Taizhou Hospital Affiliated to Wenzhou Medical University, Taizhou, Zhejiang 317000, P.R. China. jinxp155@aliyun.com.
authors.forename: Chenling
authors.initials: C
authors.lastname: Lyu
authors.forename: Yawen
authors.initials: Y
authors.lastname: Chen
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Jin
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Zhou
authors.initials: Z
authors.lastname: Zheng
authors.forename: Cai
authors.initials: C
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Hu
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Weiling
authors.initials: W
authors.lastname: Li
authors.forename: Wanfeng
authors.initials: W
authors.lastname: Wang
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D000071097:ADAMTS1 Protein; D000368:Aged; D000483:Alleles; D050197:Atherosclerosis / Q000150:complications*; D001483:Base Sequence; D001786:Blood Glucose / Q000378:metabolism; D002545:Brain Ischemia / Q000150:complications; D005215:Fasting / Q000097:blood; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D012907:Smoking; D020521:Stroke / Q000097:blood / Q000209:etiology / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D051722:ADAM Proteins; D000071097:ADAMTS1 Protein; C103859:ADAMTS1 protein, human