title: Ruthenium(0)-Catalyzed [4+2] Cycloaddition of Acetylenic Aldehydes with α-Ketols: Convergent Construction of Angucycline Ring Systems.
abstract: Ruthenium(0) complexes modified by CyJohnPhos or RuPhos catalyze the successive C-C coupling of acetylenic aldehydes with α-ketols to form [4+2] cycloadducts as single diastereomers. This method enables convergent construction of type II polyketide ring systems of the angucycline class.
authors.affiliation: University of Texas at Austin, Department of Chemistry, 105 E 24th St. A5300, Austin, TX, 78712-1167, USA.
authors.forename: Aakarsh
authors.initials: A
authors.lastname: Saxena
authors.affiliation: University of Texas at Austin, Department of Chemistry, 105 E 24th St. A5300, Austin, TX, 78712-1167, USA.
authors.forename: Felix
authors.initials: F
authors.lastname: Perez
authors.affiliation: University of Texas at Austin, Department of Chemistry, 105 E 24th St. A5300, Austin, TX, 78712-1167, USA. mkrische@mail.utexas.edu.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Krische
mesh_terms: D000114:Acetylene / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D061565:Cycloaddition Reaction; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D012428:Ruthenium; D000114:Acetylene
keywords: cycloaddition; hydrogenation; natural products; polyketides; ruthenium