title: Preliminary evidence for association of genome-wide significant DRD2 schizophrenia risk variant with clozapine response.
abstract: OBJECTIVE
  The recent Psychiatric Genomics Consortium genome-wide association study identified an SNP, rs2514218, located 47kb upstream of the DRD2 gene to be associated with risk for schizophrenia (p = 2.75e-11). Since all antipsychotics bind to dopamine D2 receptors, we examined rs2514218 in relation to response to antipsychotic treatment.
  
  
  METHODS
  We investigated the SNP in relation to treatment response in a prospective study consisting of 208 patients (151 Caucasians, 42 African-Americans and 15 others) treated with clozapine for 6 months.
  
  
  RESULTS
  rs2514218 was associated with total score change in the brief psychiatric rating scale under an additive model (pcorr= 0.033).
  
  
  CONCLUSIONS
  Our finding provides evidence for rs2514218 association with antipsychotic response, but further replication is required before firm conclusions can be drawn.
authors.affiliation: 1 King's College Circle, Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, M5S 1A8, Canada.|250 College Street, Pharmacogenetic Research Clinic, Centre for Addiction & Mental Health, Toronto, ON, M5T 1R8, Canada.
authors.forename: Eric
authors.initials: E
authors.lastname: Huang
authors.affiliation: 250 College Street, Pharmacogenetic Research Clinic, Centre for Addiction & Mental Health, Toronto, ON, M5T 1R8, Canada.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Maciukiewicz
authors.affiliation: 250 College Street, Pharmacogenetic Research Clinic, Centre for Addiction & Mental Health, Toronto, ON, M5T 1R8, Canada.
authors.forename: Clement C
authors.initials: CC
authors.lastname: Zai
authors.affiliation: 250 College Street, Pharmacogenetic Research Clinic, Centre for Addiction & Mental Health, Toronto, ON, M5T 1R8, Canada.
authors.forename: Arun K
authors.initials: AK
authors.lastname: Tiwari
authors.affiliation: 303 East Chicago Avenue, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Jiang
authors.initials: J
authors.lastname: Li
authors.affiliation: 5251 California Avenue, Department of Psychiatry & Human Behavior, University of California, Irvine, CA 92617, USA.
authors.forename: Steven G
authors.initials: SG
authors.lastname: Potkin
authors.affiliation: 1051 Riverside Drive, Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Lieberman
authors.affiliation: 303 East Chicago Avenue, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Herbert Y
authors.initials: HY
authors.lastname: Meltzer
authors.affiliation: 250 College Street, Pharmacogenetic Research Clinic, Centre for Addiction & Mental Health, Toronto, ON, M5T 1R8, Canada.|250 College Street, Department of Psychiatry, University of Toronto, Toronto, ON, M5T 1R8, Canada.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Müller
authors.affiliation: 250 College Street, Pharmacogenetic Research Clinic, Centre for Addiction & Mental Health, Toronto, ON, M5T 1R8, Canada.|250 College Street, Department of Psychiatry, University of Toronto, Toronto, ON, M5T 1R8, Canada.
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012306:Risk; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics*
chemical_list: D014150:Antipsychotic Agents; C581293:DRD2 protein, human; D017448:Receptors, Dopamine D2; D003024:Clozapine
keywords: antipsychotic; clinical response; clozapine; dopamine D2 receptor; genetics; pharmacogenetics; schizophrenia