title: Amination-Oxidation Strategy for the Copper-Catalyzed Synthesis of Monoarylamines.
abstract: A novel approach for the synthesis of monoarylamines from aryl halides is presented. This method employs an inexpensive, nontoxic metal source (copper) and incorporates a stable ammonia surrogate (α-amino acids), obviating the need for special experimental setup or handling of ammonia reagents. This process, which is proposed to proceed via an amination-oxidation sequence, selectively promotes the transformation of a range of aryl and heteroaryl iodides as well as bromides to the corresponding monoarylamines.
authors.affiliation: Department of Chemistry and Biochemistry, San Francisco State University , San Francisco, California 94132, United States.
authors.forename: Christopher
authors.initials: C
authors.lastname: Thomas
authors.affiliation: Department of Chemistry and Biochemistry, San Francisco State University , San Francisco, California 94132, United States.
authors.forename: Marvin
authors.initials: M
authors.lastname: Wu
authors.affiliation: Department of Chemistry and Biochemistry, San Francisco State University , San Francisco, California 94132, United States.
authors.forename: Kelvin L
authors.initials: KL
authors.lastname: Billingsley