title: Physical frailty in older people with severe aortic stenosis.
abstract: BACKGROUND
  Assessment of physical frailty is important among elderly with severe aortic stenosis (AS) when considering treatment.
  
  
  OBJECTIVE
  We aimed to: (1) investigate the prevalence of physical frailty in older people with severe AS and (2) examine factors related to physical frailty.
  
  
  METHODS
  A total of 125 consecutive elderly AS patients (mean age 84.6 ± 4.4 year) were enrolled. Physical frailty was defined as scoring ≤8 points on the short physical performance battery (SPPB). Factors likely related to physical frailty, including cardiac function, nutritional and metabolic status, kidney function, medical history, and comorbidities, were evaluated. Logistic regression analyses were used to examine which factors were related to physical frailty.
  
  
  RESULTS
  Physical frailty was prevalent in 38.4 %. After sex and age adjusted, the following were significantly related to physical frailty: LVEF (adjusted OR per 10 % decrease: 1.39, p < 0.05), the Mini Nutritional Assessment-Short Form (adjusted OR per 1 point decrease: 1.21, p < 0.05), serum albumin (adjusted OR per 1 g/dL decrease: 2.64, p < 0.05), HDL-C (adjusted OR per 10 mg/dL decrease: 1.52, p < 0.01), eGFR (adjusted OR per 10 mL/min decrease: 1.59, p < 0.05), grip strength (adjusted OR per 10 kg decrease: 3.60, p < 0.01), coronary heart disease (adjusted OR: 2.78, p < 0.01), cerebrovascular disease (adjusted OR: 6.06, p < 0.01), and musculoskeletal disorders (adjusted OR: 3.28, p < 0.01).
  
  
  CONCLUSIONS
  The prevalence of physical frailty is high and related to nutritional status, comorbidities, and cardiac status.
authors.affiliation: Department of Rehabilitation Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Fukui
authors.affiliation: Department of Rehabilitation Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. michiyukikawakami@hotmail.com.
authors.forename: Michiyuki
authors.initials: M
authors.lastname: Kawakami
authors.affiliation: Department of Rehabilitation Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Otaka
authors.affiliation: Department of Rehabilitation Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
authors.forename: Aiko
authors.initials: A
authors.lastname: Ishikawa
authors.affiliation: Department of Rehabilitation Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Mizuno
authors.affiliation: Department of Rehabilitation Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tsuji
authors.affiliation: Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Hayashida
authors.affiliation: Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Inohara
authors.affiliation: Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Yashima
authors.affiliation: Department of Rehabilitation Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
authors.forename: Meigen
authors.initials: M
authors.lastname: Liu
mesh_terms: D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D016330:Frail Elderly / Q000706:statistics & numerical data*; D006334:Heart Function Tests / Q000379:methods; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007677:Kidney Function Tests / Q000379:methods; D008297:Male; D009140:Musculoskeletal Diseases / Q000453:epidemiology; D009752:Nutritional Status / Q000502:physiology; D015995:Prevalence; D012720:Severity of Illness Index
keywords: Aortic stenosis; Elderly; Frailty; Nutrition