title: Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2.
abstract: Obesity is a worldwide problem that has reached epidemic proportions both in developed and developing countries. The excessive accumulation of fat poses a risk to health since it favours the development of metabolic alterations including insulin resistance and tissue inflammation, which further contribute to the progress of the complex pathological scenario observed in the obese. In this review we put together the different outcomes of fat accumulation and insulin resistance in the main insulin-responsive tissues, and discuss the role of some of the key molecular routes that control disease progression both in an organ-specific and also in a more systemic manner. In particular, we focus on the importance of studying the integrated regulation of different organs and pathways that contribute to the global pathophysiology of this condition with a specific emphasis on the role of emerging key molecular nodes such as the G protein-coupled receptor kinase 2 (GRK2) signalling hub.
authors.affiliation: a Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (UAM-CSIC) , Universidad Autónoma de Madrid , Madrid , Spain .|b Instituto de Investigación Sanitaria La Princesa , Madrid , Spain .
authors.forename: Elisa
authors.initials: E
authors.lastname: Lucas
authors.affiliation: a Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (UAM-CSIC) , Universidad Autónoma de Madrid , Madrid , Spain .|b Instituto de Investigación Sanitaria La Princesa , Madrid , Spain .
authors.forename: Marta
authors.initials: M
authors.lastname: Cruces-Sande
authors.affiliation: c Departamento de Farmacología , Universidad Autónoma de Madrid (UAM) Madrid , Spain , and.|d Instituto de Investigación Hospital Universitario La Paz (IdiPAZ) Madrid , Spain.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Briones
authors.affiliation: c Departamento de Farmacología , Universidad Autónoma de Madrid (UAM) Madrid , Spain , and.|d Instituto de Investigación Hospital Universitario La Paz (IdiPAZ) Madrid , Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Salaices
authors.affiliation: a Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (UAM-CSIC) , Universidad Autónoma de Madrid , Madrid , Spain .|b Instituto de Investigación Sanitaria La Princesa , Madrid , Spain .
authors.forename: Federico
authors.initials: F
authors.lastname: Mayor
authors.affiliation: a Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (UAM-CSIC) , Universidad Autónoma de Madrid , Madrid , Spain .|b Instituto de Investigación Sanitaria La Princesa , Madrid , Spain .
authors.forename: Cristina
authors.initials: C
authors.lastname: Murga
authors.affiliation: a Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (UAM-CSIC) , Universidad Autónoma de Madrid , Madrid , Spain .|b Instituto de Investigación Sanitaria La Princesa , Madrid , Spain .
authors.forename: Rocio
authors.initials: R
authors.lastname: Vila-Bedmar
mesh_terms: D000818:Animals; D054769:G-Protein-Coupled Receptor Kinase 2 / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D007333:Insulin Resistance; D009765:Obesity / Q000150:complications / Q000503:physiopathology*
chemical_list: D054769:G-Protein-Coupled Receptor Kinase 2
keywords: G protein-coupled receptor kinase; adipose tissue; cardiac hypertrophy; hypertension; insulin resistance; insulin signalling; liver steatosis; obesity; type 2 diabetes