title: NMP and O2 as Radical Initiator: Trifluoromethylation of Alkenes to Tertiary β-Trifluoromethyl Alcohols at Room Temperature.
abstract: A novel strategy was developed to trigger ·CF3 by using in situ generated peroxide in NMP under O2 or air as the radical initiator. Radical trifluoromethylation of alkenes was achieved toward tertiary β-trifluoromethyl alcohols. Various tertiary β-trifluoromethyl alcohols can be synthesized in good yields without extra oxidants or transition metal catalysts. Preliminary mechanistic investigation revealed that O2 diffusion can influence the reaction rate.
authors.affiliation: College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Qingquan
authors.initials: Q
authors.lastname: Lu
authors.affiliation: College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Huang
authors.affiliation: College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: National Research Center for Carbohydrate Synthesis, Jiangxi Normal University , Nanchang 330022, Jiangxi, P. R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Liao
authors.affiliation: College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Pan
authors.initials: P
authors.lastname: Peng
authors.affiliation: College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University , Wuhan, Hubei 430072, P. R. China.|State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics , Lanzhou 730000, P. R. China.
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei