title: Influence of a single-nucleotide polymorphism of the DNA mismatch repair-related gene exonuclease-1 (rs9350) with prostate cancer risk among Chinese people.
abstract: In this study, we aimed to identify the influence of exonuclease 1 (EXO1) single-nucleotide polymorphism rs9350, which is involved in DNA mismatch repair, on prostate cancer risk in Chinese people. In our hospital-based case-control study, 214 prostate cancer patients and 253 cancer-free control subjects were enrolled from three hospitals in China. Genotyping for rs9350 was performed by the SNaPshot(®) method using peripheral blood samples. Consequently, a significantly higher prostate cancer risk was observed in patients with the CC genotype [odds ratio (OR) = 1.678, 95 % confidence interval (CI) = 1.130-2.494, P = 0.010] than in those with the CT genotype. Further, the CT/TT genotypes were significantly associated with increased prostate cancer risk (adjusted OR = 1.714, 95 % CI = 1.176-2.500, P = 0.005), and the C allele had a statistically significant compared with T allele (P = 0.009) of EXO1 (rs9350). Through stratified analysis, significant associations were revealed for the CT/TT genotype in the subgroup with diagnosis age >72 (adjusted OR = 1.776, 95 % CI = 1.051-3.002, P = 0.032) and in patients with localized disease subgroup (adjusted OR = 1.798, 95 % CI = 1.070-3.022, P = 0.027). In addition, we observed that patients with prostate-specific antigen (PSA) levels of ≤10 ng/mL were more likely to have the CT/TT genotypes than those with PSA levels of >10 ng/mL (P = 0.006). For the first time, we present evidence that the inherited EXO1 polymorphism rs9350 may have a substantial influence on prostate cancer risk in Chinese people. We believe that the rs9350 could be a useful biomarker for assessing predisposition for and early diagnosis of prostate cancer.
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University, No. 253 Gongyedadaozhong Road, Haizhu District, Guangzhou, People's Republic of China, 510282.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University, No. 253 Gongyedadaozhong Road, Haizhu District, Guangzhou, People's Republic of China, 510282.
authors.forename: Pengju
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University, No. 253 Gongyedadaozhong Road, Haizhu District, Guangzhou, People's Republic of China, 510282.
authors.forename: Abai
authors.initials: A
authors.lastname: Xu
authors.affiliation: Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.|Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.affiliation: Department of Molecular Genetics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Sakai
authors.affiliation: Department of Urology, The First Affiliated Hospital of Zhejiang University, Hangzhou, People's Republic of China.
authors.forename: Liping
authors.initials: L
authors.lastname: Xie
authors.affiliation: Peking University Wu-jieping Urology Center, Peking University Shougang Hospital, Peking, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Peking University Wu-jieping Urology Center, Peking University Shougang Hospital, Peking, People's Republic of China.
authors.forename: Yanqun
authors.initials: Y
authors.lastname: Na
authors.affiliation: Department of Urology, Okamura Isshindow Hospital, Okayama, Japan.
authors.forename: Haruki
authors.initials: H
authors.lastname: Kaku
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University, No. 253 Gongyedadaozhong Road, Haizhu District, Guangzhou, People's Republic of China, 510282.
authors.forename: Peng
authors.initials: P
authors.lastname: Xu
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University, No. 253 Gongyedadaozhong Road, Haizhu District, Guangzhou, People's Republic of China, 510282.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University, No. 253 Gongyedadaozhong Road, Haizhu District, Guangzhou, People's Republic of China, 510282.
authors.forename: Xiezhao
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University, No. 253 Gongyedadaozhong Road, Haizhu District, Guangzhou, People's Republic of China, 510282.
authors.forename: Kai
authors.initials: K
authors.lastname: Guo
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University, No. 253 Gongyedadaozhong Road, Haizhu District, Guangzhou, People's Republic of China, 510282.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Shen
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University, No. 253 Gongyedadaozhong Road, Haizhu District, Guangzhou, People's Republic of China, 510282.
authors.forename: Shaobo
authors.initials: S
authors.lastname: Zheng
authors.affiliation: Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.|Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kumon
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University, No. 253 Gongyedadaozhong Road, Haizhu District, Guangzhou, People's Republic of China, 510282. liuchx888@hotmail.com.
authors.forename: Chunxiao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University, No. 253 Gongyedadaozhong Road, Haizhu District, Guangzhou, People's Republic of China, 510282. huangpeng509@gmail.com.|Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. huangpeng509@gmail.com.|Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan. huangpeng509@gmail.com.|Okayama Medical Innovation Center, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. huangpeng509@gmail.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D053843:DNA Mismatch Repair; D005090:Exodeoxyribonucleases / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors
chemical_list: D005090:Exodeoxyribonucleases; C028450:exodeoxyribonuclease I
keywords: DNA mismatch repair; EXO1; Prostate cancer; Single-nucleotide polymorphisms; rs9350