title: Two Cases of Intravascular Lymphoma Diagnosed by Gastrointestinal Endoscopic Biopsy.
abstract: Two cases of intravascular lymphoma (IVL) were diagnosed by endoscopic biopsy. Both patients were admitted to our hospital with a fever of an unknown origin. An elevated serum level of soluble interleukin-2 receptor antibody suggested IVL. An upper gastrointestinal endoscopy was performed. A biopsy of both the reddened and normal gastroduodenal mucosa (Case 1) and a biopsy of a gastric antral ulcer, multiple polyploid lesions resembling submucosal tumors in the duodenum, and the patient's normal mucosa (Case 2) revealed vascular infiltration by CD20-positive atypical lymphocytes, confirming the diagnosis of IVL. The performance of a gastrointestinal biopsy for suspected IVL is important, even if there are no visible endoscopic abnormalities.
authors.affiliation: Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Shimoyama
authors.forename: Kensuke
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Mie
authors.initials: M
authors.lastname: Kotake
authors.forename: Daisuke
authors.initials: D
authors.lastname: Uehara
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kamide
authors.forename: Shiko
authors.initials: S
authors.lastname: Kuribayashi
authors.forename: Osamu
authors.initials: O
authors.lastname: Kawamura
authors.forename: Motoyasu
authors.initials: M
authors.lastname: Kusano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Handa
authors.forename: Junko
authors.initials: J
authors.lastname: Hirato
authors.forename: Masanobu
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001706:Biopsy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004386:Duodenum / Q000473:pathology*; D004724:Endoscopy; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D000069283:Rituximab / Q000008:administration & dosage; D013163:Splenomegaly / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D019043:Vascular Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone