title: [Research Progress in Mixed Lineage Kinase Domain-Like].
abstract: Necroptosis is a novel programmed cell death mechanism which is caspase independent. It is mediated by specific signaling via a death receptor ligation. Necroptosis usuaUy arises when the apoptotic Pathway is inhibited, and is characterized by a necrotic morphology. Recently many reports have revealed that necroptosis is precisely regulated by a cellular signaling pathway, like apoptosis. Receptor interaction protein kinase 1 and receptor interaction protein kinase 3 kinases are the key regulators of this alternative cell death mechanism. MLKL plays an important role in TNF-induced programmed necrosis pathway. In this paper physiological function and molecular mechanism were reviewed.
authors.forename: Wang
authors.initials: W
authors.lastname: Fang
authors.forename: Zhong-Sheng
authors.initials: ZS
authors.lastname: Jia
authors.forename: Zhong-Sheng
authors.initials: ZS
authors.lastname: Tong
mesh_terms: D017209:Apoptosis; D016923:Cell Death; D009336:Necrosis; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011494:Protein Kinases