title: canSAR: an updated cancer research and drug discovery knowledgebase.
abstract: canSAR (http://cansar.icr.ac.uk) is a publicly available, multidisciplinary, cancer-focused knowledgebase developed to support cancer translational research and drug discovery. canSAR integrates genomic, protein, pharmacological, drug and chemical data with structural biology, protein networks and druggability data. canSAR is widely used to rapidly access information and help interpret experimental data in a translational and drug discovery context. Here we describe major enhancements to canSAR including new data, improved search and browsing capabilities, new disease and cancer cell line summaries and new and enhanced batch analysis tools.
authors.affiliation: Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Tym
authors.affiliation: Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.
authors.forename: Costas
authors.initials: C
authors.lastname: Mitsopoulos
authors.affiliation: Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Coker
authors.affiliation: Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.
authors.forename: Parisa
authors.initials: P
authors.lastname: Razaz
authors.affiliation: Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.
authors.forename: Amanda C
authors.initials: AC
authors.lastname: Schierz
authors.affiliation: Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.
authors.forename: Albert A
authors.initials: AA
authors.lastname: Antolin
authors.affiliation: Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK bissan.al-lazikani@icr.ac.uk.
authors.forename: Bissan
authors.initials: B
authors.lastname: Al-Lazikani
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002986:Clinical Trials as Topic; D055808:Drug Discovery; D015870:Gene Expression; D006801:Humans; D051188:Knowledge Bases; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D009363:Neoplasm Proteins