title: Association Between Prostate Volume and Red Cell Distribution Width.
abstract: OBJECTIVE
  To evaluate relation between red cell distribution width (RDW) and benign prostatic hyperplasia (BPH).
  
  
  METHODS
  The overall study population consisted of 942 men with lower urinary tract symptoms (LUTS), ranging in age from 60 to 85 years old. Patients with disorder or medication that can influence lower urinary tract or erythrocytes were excluded from the study. The relationship between RDW, white blood cell (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and prostate volume, International Prostate Symptom Score (IPSS) were assessed with multivariate linear regression model. Patients were analyzed in four groups stratified according to the quartiles of prostate volume. The one-way analysis of variance (anova) was used to compare RDW, WBC CRP, and ESR between different quartiles of prostate volume.
  
  
  RESULTS
  A graded and independent association of RDW with the prostate volume was identified (P = 0.001). RDW was significantly associated with prostate volume in multivariate linear regression model that was adjusted for age and hemoglobin. IPSS was significantly correlated with RDW, CRP and ESR. However significance was lost after adjustment for age and prostate volume. The RDW was significantly associated with the surgical treatment in the multivariate linear regression model that was adjusted for age and prostate volume.
  
  
  CONCLUSIONS
  A correlation between an increased RDW and prostate volume was suggested by the new data from this study. This relation may be a consequence of inflammatory stress arising from BPH. The significant association between the easy, inexpensive RDW may provide a rational basis to include the RDW in algorithms for surgery risk prediction.
authors.affiliation: Department of Urology, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Orhan Ü
authors.initials: OÜ
authors.lastname: Zorba
authors.affiliation: Department of Urology, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Hakkı
authors.initials: H
authors.lastname: Uzun
authors.affiliation: Department of Urology, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Önem
authors.affiliation: Department of Urology, Mugla University, Mugla, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Çetinkaya
authors.affiliation: Department of Urology, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Rifaioğlu
authors.affiliation: Department of Urology, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Nezih
authors.initials: N
authors.lastname: Akça
keywords: benign prostatic hyperplasia; inflammation; red cell distribution width