title: A Door Opens for Fibrodysplasia Ossificans Progressiva.
abstract: Fibrodysplasia ossificans progressiva (FOP), characterized by extra bone formation in soft tissues, is caused by a gain-of-function mutation in ACVR1, a transmembrane receptor. Recently, a potential treatment was developed by identifying a novel molecular mechanism underlying bone formation in FOP. These findings have opened the door to beating FOP.
authors.affiliation: Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241, Japan. Electronic address: katagiri@saitama-med.ac.jp.
authors.forename: Takenobu
authors.initials: T
authors.lastname: Katagiri
mesh_terms: D000818:Animals; D018450:Disease Progression; D006801:Humans; D051379:Mice; D009154:Mutation; D009221:Myositis Ossificans / Q000235:genetics* / Q000473:pathology
keywords: activin; bone morphogenetic protein (BMP); heterotopic ossification; intracellular signaling; ligand; receptor