title: Quantification and bio-assay of α-glucosidase inhibitors from the roots of Glycyrrhiza uralensis Fisch.
abstract: This work aimed to investigate the α-glucosidase inhibitor from the roots of Glycyrrhiza uralensis Fisch. Seven flavonoids were isolated, and the total content of compounds 1-7 were more than 50% in Glycyrrhiza total flavones (GTF), and the content of compound 1 and 2 was abundant in GTF. The results of the α-glucosidase inhibitory activities indicated that compounds 1-6 and GTF respectively with the IC50 values of 31.303, 30.263, 23.363, 19.528, 10.854, 26.454 and 21.641 μg/mL exhibited the more potent activity than acarbose with the IC50 values of 38.995 μg/mL. These result suggested that Glycyrrhiza flavonoids may become a valid alternative of potential basis for new hypoglycaemic and antidiabetic agents.
authors.affiliation: a Institute of Pharmaceutics, School of Pharmacy , Lanzhou University , Lanzhou , PR China.
authors.forename: San-Hu
authors.initials: SH
authors.lastname: Gou
authors.affiliation: b Department of Pharmacy , Gansu Provincial Hospital , Lanzhou , PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: a Institute of Pharmaceutics, School of Pharmacy , Lanzhou University , Lanzhou , PR China.
authors.forename: Miao
authors.initials: M
authors.lastname: He
authors.affiliation: a Institute of Pharmaceutics, School of Pharmacy , Lanzhou University , Lanzhou , PR China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Qiang
authors.affiliation: a Institute of Pharmaceutics, School of Pharmacy , Lanzhou University , Lanzhou , PR China.
authors.forename: Jing-Man
authors.initials: JM
authors.lastname: Ni
mesh_terms: D020909:Acarbose / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D029882:Glycyrrhiza uralensis / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D013329:Structure-Activity Relationship; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D005419:Flavonoids; D065089:Glycoside Hydrolase Inhibitors; D000520:alpha-Glucosidases; D020909:Acarbose
keywords: Glycyrrhiza uralensis; antidiabetic; flavonoid; hypoglycaemic; licorice; α-glucosidase