title: Pneumococcal pneumonia prevention among adults: is the herd effect of pneumococcal conjugate vaccination in children as good a way as the active immunization of the elderly?
abstract: The indirect protection of adults as a result of pneumococcal conjugate vaccination of infants has been discussed from different epidemiological points of view. In some countries, including Italy, even after pediatric vaccination, vaccine serotypes are still responsible for most pneumonia and invasive diseases in the elderly. Although the Community-Acquired Pneumonia Immunization Trial in Adults (CAPITA) produced encouraging results, it has not showed the efficacy of the 13-valent conjugate vaccine in preventing pneumococcal community-acquired pneumonia regardless of the number of episodes and serotype. Addressing these points by monitoring the direct impact of adult vaccination in real life distinguished from the effects of herd immunity will assist public health decision-making on the most effective adult pneumococcal vaccination strategies.
authors.affiliation: a Department of Medical and Surgical Sciences , University of Foggia , Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Prato
authors.affiliation: a Department of Medical and Surgical Sciences , University of Foggia , Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Fortunato
authors.affiliation: a Department of Medical and Surgical Sciences , University of Foggia , Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Martinelli
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D017714:Community-Acquired Infections / Q000517:prevention & control*; D003657:Decision Making; D006801:Humans; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D011018:Pneumonia, Pneumococcal / Q000517:prevention & control*; D014611:Vaccination; D018074:Vaccines, Conjugate / Q000008:administration & dosage
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate
keywords: CAPITA; PCV13 efficacy; Pneumococcal adult vaccination; Pneumococcal disease; Pneumococcal herd immunity