title: Central nervous system (CNS) cancer in children and young people in the European Union and its involvements with socio-economic and environmental factors.
abstract: Malignant central nervous system (CNS) tumors are the leading cause of death by cancer in children and the second commonest pediatric cancer type. Despite several decades of epidemiologic research, the etiology of childhood CNS tumors is still largely unknown. A few genetic syndromes and therapeutic ionizing radiation are thought to account for 5-10% of childhood cancer, but the etiology of other cases remains unknown. Nongenetic causes, like environmental agents, are thought to explain them. However, as very few epidemiologic studies have been conducted, it is not surprising that nongenetic risk factors have not been detected. The biggest difference between cancers for which there are good etiologic clues and those for which there are none could be the number of relevant studies. This study, which covers the 1980-2011 period, identified links between CNS cancer evolution and the socio-economic and environmental indicators in the same space and time limits in the European Union.
authors.affiliation: Public Health and Environmental Care Unit, Department of Preventive Medicine, University of Valencia, Valencia, Spain; CIBER Epidemiologia y Salud Pública (CIBERESP), Spain; Center for Advanced Research in Public Health, CSISP-FISABIO, Valencia, Spain.
authors.forename: Agustín
authors.initials: A
authors.lastname: Llopis-González
authors.affiliation: Public Health and Environmental Care Unit, Department of Preventive Medicine, University of Valencia, Valencia, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Alcaide Capilla
authors.affiliation: Public Health and Environmental Care Unit, Department of Preventive Medicine, University of Valencia, Valencia, Spain.
authors.forename: Unai
authors.initials: U
authors.lastname: Chenlo Alonso
authors.affiliation: Public Health and Environmental Care Unit, Department of Preventive Medicine, University of Valencia, Valencia, Spain; CIBER Epidemiologia y Salud Pública (CIBERESP), Spain; Center for Advanced Research in Public Health, CSISP-FISABIO, Valencia, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Rubio-López
authors.affiliation: Biomedical Sciences Department, Universidad Cardenal Herrera CEU, Valencia, Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Alegre-Martinez
authors.affiliation: Public Health and Environmental Care Unit, Department of Preventive Medicine, University of Valencia, Valencia, Spain; CIBER Epidemiologia y Salud Pública (CIBERESP), Spain; Center for Advanced Research in Public Health, CSISP-FISABIO, Valencia, Spain. Electronic address: maria.m.morales@uv.es.
authors.forename: María
authors.initials: M
authors.lastname: Morales Suárez-Varela
mesh_terms: D000293:Adolescent; D016543:Central Nervous System Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D002648:Child; D015331:Cohort Studies; D004777:Environment; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D012959:Socioeconomic Factors; D013997:Time Factors; D055815:Young Adult
keywords: Cancer; Central nervous system (CNS); Children; Environment; Industrialization; Socio-economic