title: PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition.
abstract: Innate immunity consists of a cellular and a humoral arm. PTX3 is a fluid patter recognition molecule (PRM) with antibody-like properties. Gene targeted mice and genetic associations in humans suggest that PTX3 plays a non-redundant role in resistance against selected pathogens (e.g. Aspergillus fumigatus, Pseudomonas aeruginosa, uropathogenic Escherichia coli) and in the regulation of inflammation. PTX3 acts as an extrinsic oncosuppressor by taming complement elicited tumor-promoting inflammation. Recent results indicate that, by interacting with provisional matrix components, PTX3 contributes to the orchestration of tissue repair. An acidic pH sets PTX3 in a tissue repair mode, while retaining anti-microbial recognition. Based on these data and scattered information on humoral PRM and matrix components, we surmise that matrix and microbial recognition are related functions in evolution.
authors.affiliation: Humanitas Clinical Research Center, via Manzoni 56, 20089, Rozzano (Milano), Italy.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Garlanda
authors.affiliation: Humanitas Clinical Research Center, via Manzoni 56, 20089, Rozzano (Milano), Italy.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Jaillon
authors.affiliation: Humanitas Clinical Research Center, via Manzoni 56, 20089, Rozzano (Milano), Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Doni
authors.affiliation: Humanitas Clinical Research Center, via Manzoni 56, 20089, Rozzano (Milano), Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Bottazzi
authors.affiliation: Humanitas Clinical Research Center, via Manzoni 56, 20089, Rozzano (Milano), Italy; Humanitas University, via Manzoni 56, 20089 Rozzano, Italy. Electronic address: alberto.mantovani@humanitasresearch.it.
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D002097:C-Reactive Protein / Q000235:genetics / Q000276:immunology*; D003165:Complement System Proteins / Q000235:genetics / Q000276:immunology; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions; D006801:Humans; D056724:Immunity, Humoral; D007113:Immunity, Innate; D007249:Inflammation; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000276:immunology*; D051192:Receptors, Pattern Recognition / Q000235:genetics / Q000276:immunology; D000683:Serum Amyloid P-Component / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D003165:Complement System Proteins; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D051192:Receptors, Pattern Recognition; D000683:Serum Amyloid P-Component; D000099153:Pentraxins