title: Synthesis of 4-Ynamides and Cyclization by the Vilsmeier Reagent to Dihydrofuran-2(3H)-ones.
abstract: The room-temperature nucleophilic addition of vinyl azides to propargylic alcohols under BF3·Et2O catalysis provides an efficient synthesis of 4-ynamides. The procedure is operationally convenient, shows broad substrate scope, and is viable for the synthesis of multifunctional 4-ynamides. Further, a Vilsmeier intramolecular cyclization of 4-ynamides into dihydrofuran-2(3H)-ones has also been discovered, which represents the first report of alkynes being used as the nucleophiles in Vilsmeier-type reactions.
authors.affiliation: College of Pharmacy, Jiamusi University , Jiamusi 154007, China.
authors.forename: Zhaocheng
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Northeast Normal University , Changchun 130024, China.
authors.forename: Rapolu Kiran
authors.initials: RK
authors.lastname: Kumar
authors.affiliation: College of Pharmacy, Jiamusi University , Jiamusi 154007, China.
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Li
authors.affiliation: College of Pharmacy, Jiamusi University , Jiamusi 154007, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Chemistry, Northeast Normal University , Changchun 130024, China.|College of Pharmacy, Jiamusi University , Jiamusi 154007, China.|State Key Laboratory of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, China.
authors.forename: Xihe
authors.initials: X
authors.lastname: Bi