title: Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.
abstract: BACKGROUND
  The Wnt signaling pathway involves secreted glycoproteins that bind to the Frizzled family receptors to activate intracellular signal transduction events that regulate cell proliferation, apoptosis, cell migration and many critical aspects of developmental biology.
  
  
  CONCLUSIONS
  Aberrant Wnt signaling underlies a wide range of pathologies in humans including tumor initiation, tumor growth, cell senescence, cell death, differentiation and metastasis. The inhibition of Wnt signaling offers a novel approach for anticancer therapeutics.
  
  
  CONCLUSIONS
  Focusing on recent developments, we reviewed the small-molecule inhibitors targeting various components of Wnt signaling pathways and the progress from the discovery of lead compounds to highly potent inhibitors with significant therapeutic potential.
authors.affiliation: RCMI Cancer Research Center, Xavier University of Louisiana, New Orleans, LA 70125, USA.|Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA.
authors.forename: Shilong
authors.initials: S
authors.lastname: Zheng
authors.affiliation: RCMI Cancer Research Center, Xavier University of Louisiana, New Orleans, LA 70125, USA.|Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA.
authors.forename: Jiawang
authors.initials: J
authors.lastname: Liu
authors.affiliation: Division of Cancer Research & Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.|Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.
authors.forename: Yanyuan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: RCMI Cancer Research Center, Xavier University of Louisiana, New Orleans, LA 70125, USA.|School of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125, USA.
authors.forename: Tien L
authors.initials: TL
authors.lastname: Huang
authors.affiliation: RCMI Cancer Research Center, Xavier University of Louisiana, New Orleans, LA 70125, USA.|Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA.
authors.forename: Guangdi
authors.initials: G
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D055808:Drug Discovery; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D060449:Wnt Signaling Pathway / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D054852:Small Molecule Libraries