title: Three-way analysis of the UPLC-PDA dataset for the multicomponent quantitation of hydrochlorothiazide and olmesartan medoxomil in tablets by parallel factor analysis and three-way partial least squares.
abstract: An application of parallel factor analysis (PARAFAC) and three-way partial least squares (3W-PLS1) regression models to ultra-performance liquid chromatography-photodiode array detection (UPLC-PDA) data with co-eluted peaks in the same wavelength and time regions was described for the multicomponent quantitation of hydrochlorothiazide (HCT) and olmesartan medoxomil (OLM) in tablets. Three-way dataset of HCT and OLM in their binary mixtures containing telmisartan (IS) as an internal standard was recorded with a UPLC-PDA instrument. Firstly, the PARAFAC algorithm was applied for the decomposition of three-way UPLC-PDA data into the chromatographic, spectral and concentration profiles to quantify the concerned compounds. Secondly, 3W-PLS1 approach was subjected to the decomposition of a tensor consisting of three-way UPLC-PDA data into a set of triads to build 3W-PLS1 regression for the analysis of the same compounds in samples. For the proposed three-way analysis methods in the regression and prediction steps, the applicability and validity of PARAFAC and 3W-PLS1 models were checked by analyzing the synthetic mixture samples, inter-day and intra-day samples, and standard addition samples containing HCT and OLM. Two different three-way analysis methods, PARAFAC and 3W-PLS1, were successfully applied to the quantitative estimation of the solid dosage form containing HCT and OLM. Regression and prediction results provided from three-way analysis were compared with those obtained by traditional UPLC method.
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100 Tandoğan, Ankara, Turkey. Electronic address: dinc@ankara.edu.tr.
authors.forename: Erdal
authors.initials: E
authors.lastname: Dinç
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100 Tandoğan, Ankara, Turkey.
authors.forename: Zehra Ceren
authors.initials: ZC
authors.lastname: Ertekin
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods / Q000592:standards; D016208:Databases, Factual / Q000592:standards; D005163:Factor Analysis, Statistical; D006852:Hydrochlorothiazide / Q000032:analysis*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D016018:Least-Squares Analysis; D000068557:Olmesartan Medoxomil / Q000032:analysis*; D013607:Tablets
chemical_list: D013607:Tablets; D006852:Hydrochlorothiazide; D000068557:Olmesartan Medoxomil
keywords: Chromatographic spectral three-way array; Hydrochlorothiazide; Olmesartan medoxomil; Parallel factor analysis; Tablet; Three-way partial least squares