title: [Excerpts from the collaborative lung cancer research program of Semmelweis University, the National Institute of Oncology and Korányi Institute of TB and Pulmonology (2010-2015)].
abstract: Lung cancer places a significant socio-economic burden on the Hungarian population. This overview summarizes the findings of collaborative translational lung cancer research efforts of three Hungarian flagship academic institutions, the Semmelweis University, the National Institute of Oncology and the National Koranyi Institute of TB and Pulmonology. With regards to the molecular factors regulating tumor angiogenesis, we identified the prognostic significance of apelin and erythropoietin receptor (EPOR) expression in non-small cell lung cancer (NSCLC). Furthermore, the impact of KRAS mutation subtypes and ERCC1 (excision repair cross-complementation group 1) expression on the response to platinum-based chemotherapy have been studied. We also described the epidemiology and predictive power of rare EGFR (epidermal growth factor receptor) mutations in a large Hungarian patient cohort. Lastly, the expression of molecular factors associated with NSCLC progression was studied specifically in brain metastatic matched cases series. These preclinical and clinical studies provide clinically relevant information that hopefully will contribute to the improvement of lung cancer patient care.
authors.affiliation: Molekuláris Onkológia Kutatócsoport, MTA-SE, Budapest, Hungary.
authors.forename: Balázs
authors.initials: B
authors.lastname: Hegedûs
authors.affiliation: Országos Korányi Tbc és Pulmonológiai Intézet, Budapest, Hungary.
authors.forename: Judit
authors.initials: J
authors.lastname: Moldvay
authors.affiliation: Országos Korányi Tbc és Pulmonológiai Intézet, Budapest, Hungary.
authors.forename: Judit
authors.initials: J
authors.lastname: Berta
authors.affiliation: Országos Korányi Tbc és Pulmonológiai Intézet, Budapest, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Lohinai
authors.affiliation: Országos Korányi Tbc és Pulmonológiai Intézet, Budapest, Hungary.
authors.forename: Anita
authors.initials: A
authors.lastname: Rózsás
authors.affiliation: Országos Korányi Tbc és Pulmonológiai Intézet, Budapest, Hungary.
authors.forename: Mihály T
authors.initials: MT
authors.lastname: Cserepes
authors.affiliation: Pulmonológiai Klinika, Semmelweis Egyetem, Budapest, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Fábián
authors.affiliation: Országos Korányi Tbc és Pulmonológiai Intézet, Budapest, Hungary.
authors.forename: Gyula
authors.initials: G
authors.lastname: Ostoros
authors.affiliation: Kísérletes Farmakológiai Osztály, Országos Onkológiai Intézet, Budapest, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Tóvári
authors.affiliation: Mellkassebészeti Klinika, Semmelweis Egyetem-Országos Onkológiai Intézet, Budapest, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Rényi-Vámos
authors.affiliation: II. Sz. Patológiai Intézet, Semmelweis Egyetem, Budapest, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Tímár
authors.affiliation: Mellkassebészeti Tanszék, Bécsi Orvostudományi Egyetem, Bécs, Austria. domeb@yahoo.com.
authors.forename: Balázs
authors.initials: B
authors.lastname: Döme