title: Profluorescent substrates for the screening of olefin metathesis catalysts.
abstract: Herein we report on a 96-well plate assay based on the fluorescence resulting from the ring-closing metathesis of two profluorophoric substrates. To demonstrate the validity of the approach, four commercially available ruthenium-metathesis catalysts were evaluated in six different solvents. The results from the fluorescent assay agree well with HPLC conversions, validating the usefulness of the approach.
authors.affiliation: Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland.
authors.forename: Raphael
authors.initials: R
authors.lastname: Reuter
authors.affiliation: Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Ward
keywords: fluorescence; microplate screening; ring closing metathesis