title: A novel cotton fabric with anti-bacterial and drug delivery properties using SBA-15-NH2/polysiloxane hybrid containing tetracycline.
abstract: Here, mesoporous silica particles containing tetracycline were loaded on cotton fabric for possible application on the infected human skin. Amino functionalized mesoporous silica, SBA-15-NH2, was chosen as a safe drug carrier loaded with tetracycline via post impregnation method. Diverse content of the drug loaded silica particles were then attached on the cotton fabric surface using polysiloxane reactive softener as a soft and safe fixing agent. UV-Vis spectroscopy was used to study the drug delivery properties of the mesoporous silica on the treated cotton fabrics. The treated fabric with long drug release properties was selected as the optimized sample. Further analysis was carried out on this sample including anti-bacterial, water contact angle, bending length, mineral content and washing durability. Also, SEM images, EDX patterns, X-Ray spectra and thermal behavior of the optimum sample were studied. The optimized treated sample indicated the gradual release profile of tetracycline in PBS buffer media within 48h along with excellent anti-bacterial efficiency as a good feature for biological application.
authors.affiliation: Department of Textile Engineering, Functional Fibrous Structures & Environmental Enhancement (FFSEE), Amirkabir University of Technology (Tehran Polytechnic), P.O. Box 15875-4413, Tehran, Iran.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Hashemikia
authors.affiliation: Department of Textile Engineering, Functional Fibrous Structures & Environmental Enhancement (FFSEE), Amirkabir University of Technology (Tehran Polytechnic), P.O. Box 15875-4413, Tehran, Iran. Electronic address: hemmati@aut.ac.ir.
authors.forename: Nahid
authors.initials: N
authors.lastname: Hemmatinejad
authors.affiliation: Chemistry Department, University of Zanjan, P.O. Box 45195-313, Zanjan, Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Ahmadi
authors.affiliation: Department of Textile Engineering, Functional Fibrous Structures & Environmental Enhancement (FFSEE), Amirkabir University of Technology (Tehran Polytechnic), P.O. Box 15875-4413, Tehran, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Montazer
mesh_terms: D032561:Cotton Fiber; D016503:Drug Delivery Systems / Q000379:methods*; D004926:Escherichia coli / Q000254:growth & development*; D006801:Humans; D012822:Silicon Dioxide / Q000737:chemistry / Q000494:pharmacology; D012833:Siloxanes / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000254:growth & development*; D013752:Tetracycline / Q000737:chemistry / Q000494:pharmacology
chemical_list: C509969:SBA-15; D012833:Siloxanes; D012822:Silicon Dioxide; D013752:Tetracycline
keywords: Anti-bacterial cotton; Drug delivery; Mesoporous silica; SBA-15-NH(2); Silicone softener