title: Solid phase extraction of amoxicillin using dibenzo-18-crown-6 modified magnetic-multiwalled carbon nanotubes prior to its spectrophotometric determination.
abstract: This work reports on a method for selective extraction and sensitive determination of amoxicillin drug (AMX). The method is based on solid phase extraction of AMX by a novel modified magnetic nanoadsorbent prior to spectrophotometric determination of AMX using a procedure based on formation a colored azo-derivative of the investigated drug. The nanoadsorbent has been synthesized by modification of magnetic-multiwalled carbon nanotube with dibenzo-18-crown-6 moieties. The synthesized nanoparticles were characterized using TEM, XRD and FT-IR measurements. At the next step, various factors that could potentially affect adsorption and desorption efficiencies of AMX, have been optimized. The results showed that under the optimized conditions, sensitive and selective determination of the investigated drug in concentration range of 5.0-1000.0 ng mL(-1) with the limit of detection of 3.0 ng mL(-1) was achievable. Furthermore, the real sample analysis (i.e. amoxicillin capsules and human urine samples) results indicated that a reliable promising candidate method has been developed for the determination of AMX in the investigated real samples.
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran. Electronic address: m.ahmadi@basu.ac.ir.
authors.forename: Mazaher
authors.initials: M
authors.lastname: Ahmadi
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran. Electronic address: madrakian@basu.ac.ir.
authors.forename: Tayyebeh
authors.initials: T
authors.lastname: Madrakian
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Afkhami
mesh_terms: D000658:Amoxicillin / Q000032:analysis / Q000652:urine*; D043844:Crown Ethers / Q000737:chemistry*; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000652:urine
chemical_list: D043844:Crown Ethers; D058185:Magnetite Nanoparticles; D037742:Nanotubes, Carbon; D014874:Water Pollutants, Chemical; C002564:dibenzo-18-crown-6; D000658:Amoxicillin
keywords: Amoxicillin; Modified magnetic-multiwalled carbon nanotubes; Preconcentration; Removal; Solid phase extraction; Spectrophotometric determination