title: Individual differences in the expression of conditioned fear are associated with endogenous fibroblast growth factor 2.
abstract: These experiments examined the relationship between the neurotrophic factor fibroblast growth factor 2 (FGF2) and individual differences in the expression of conditioned fear. Experiments 1 and 2 demonstrated that rats naturally expressing low levels of contextual or cued fear have higher levels of hippocampal FGF2 relative to rats that express high levels of conditioned fear and nonconditioned rats. Experiment 3 demonstrated that hippocampal FGF2 is not increased in rats that exhibit pharmacological-induced amnesia of conditioned fear. Together, these experiments provide evidence that FGF2 may be an endogenous regulator of fear responses to conditioned stimuli.
authors.affiliation: School of Psychology, The University of New South Wales Australia, Sydney, 2052 New South Wales, Australia bgraham@psy.unsw.edu.au.
authors.forename: Bronwyn M
authors.initials: BM
authors.lastname: Graham
authors.affiliation: School of Psychology, The University of New South Wales Australia, Sydney, 2052 New South Wales, Australia.
authors.forename: Rick
authors.initials: R
authors.lastname: Richardson
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004597:Electroshock / Q000009:adverse effects; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005239:Fear / Q000187:drug effects; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects / Q000502:physiology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007206:Individuality; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018691:Excitatory Amino Acid Antagonists; D016222:Fibroblast Growth Factor 2; D016291:Dizocilpine Maleate