title: How hematopoietic stem/progenitors and their niche sense and respond to infectious stress.
abstract: Hematopoietic stem/progenitor cells (HSPCs) play important roles in fighting systemic infection as they supply immune cells in a demand-adapted manner. Various mechanisms govern HSPC responses to infection, including cytokine signaling, niche function, and direct sensing of pathogen-derived molecules by HSPCs themselves. Here we review recent advances in our understanding of HSPC responses to infection and also consider newly identified STING-mediated machinery recognizing bacteria-derived cyclic dinucleotides.
authors.affiliation: Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kobayashi
authors.affiliation: Cancer Science Institute, National University of Singapore, Singapore.
authors.forename: Toshio
authors.initials: T
authors.lastname: Suda
authors.affiliation: Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan. Electronic address: keiyot@gmail.com.
authors.forename: Keiyo
authors.initials: K
authors.lastname: Takubo
mesh_terms: D003141:Communicable Diseases / Q000473:pathology*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D013312:Stress, Physiological