title: Long-term Outcomes After Radiosurgery for Temporal Bone Paragangliomas.
abstract: To determine the long-term outcome after stereotactic radiosurgery (SRS) for temporal bone paragangliomas.
  
  
  
  We retrospectively reviewed the medical records of 11 patients with temporal bone paragangliomas (10 patients with a glomus jugulare tumor and 1 patient with a glomus tympanicum tumor) treated between January 1997 and July 2012 at the University of Florida with SRS to a median dose of 15 Gy in 1 fraction. Ten previously unirradiated patients received SRS as did 1 patient who received prior fractionated radiotherapy (FRT) and then received salvage SRS for a local recurrence. The major outcome endpoint was local control, meaning no further growth or shrinkage on follow-up computed tomography or magnetic resonance imaging scans.
  
  
  
  The median follow-up time was 5.3 years. Two patients developed a local recurrence after SRS, including the patient who received salvage SRS after prior FRT. The overall local control rates at 5 and 10 years were both 81%. The cause-specific survival rates at 5 and 10 years were both 88%. The distant metastasis-free survival rates at 5 and 10 years were both 100%. The overall survival rates at 5 and 10 years were both 78%. There were no severe complications.
  
  
  
  SRS for benign head and neck paragangliomas is a safe and efficacious treatment associated with minimal morbidity. SRS is suitable for patients with skull base tumors <3 cm when FRT is logistically unsuitable. Surgery is reserved for patients in good health whose risk of associated morbidity is low. Observation is a reasonable option for asymptomatic patients with a limited life expectancy.
authors.affiliation: Departments of Radiation Oncology.
authors.forename: Stacey M
authors.initials: SM
authors.lastname: Scheick
authors.affiliation: Departments of Radiation Oncology.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Morris
authors.affiliation: Departments of Radiation Oncology.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Amdur
authors.affiliation: Neurosurgery, University of Florida College of Medicine, Gainesville, FL.
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Bova
authors.affiliation: Neurosurgery, University of Florida College of Medicine, Gainesville, FL.
authors.forename: William A
authors.initials: WA
authors.lastname: Friedman
authors.affiliation: Neurosurgery, University of Florida College of Medicine, Gainesville, FL.
authors.forename: William M
authors.initials: WM
authors.lastname: Mendenhall
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010236:Paraganglioma, Extra-Adrenal / Q000401:mortality / Q000601:surgery*; D016634:Radiosurgery / Q000379:methods* / Q000401:mortality; D012189:Retrospective Studies; D012888:Skull Neoplasms / Q000401:mortality / Q000601:surgery*; D013701:Temporal Bone / Q000473:pathology; D016896:Treatment Outcome