title: Intrapulmonary concentration of enrofloxacin in healthy calves.
abstract: To determine the intrapulmonary concentration of enrofloxacin (ERFX) in calves, plasma, bronchoalveolar lavage fluid (BALF) and alveolar cells samples were obtained from clinically healthy calves. Four clinically healthy calves were administered a single dose of ERFX (5 mg/kg) by subcutaneous injection. Samples of plasma were obtained for each subjects at 0 (before administration), 1 and 2 hr after administration of ERFX. Samples of BALF were obtained from each subject at 0, 1 and 2 hr after administration of ERFX. This examination was conducted two times, one week apart. The mean EFRX concentrations in plasma at 1 and 2 hr after administration were l.23 and 1.29 µg/ml, respectively. The mean EFRX concentrations in pulmonary epithelial lining fluid (ELF) at 1 and 2 hr after administration 8.53 µg/ml and 9.42 µg/ml, respectively. The mean ERFX concentrations of alveolar cells in BALF at 1 and 2 hr after administration were 4.04 µg/ml and 5.19 µg/ml, respectively. These results suggest that the ERFX concentrations in ELF and alveolar cells concentrations in BALF at 1 and 2 hr after administration were higher than the plasma concentrations.
authors.affiliation: Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.
authors.forename: Konosuke
authors.initials: K
authors.lastname: Otomaru
authors.forename: Masaya
authors.initials: M
authors.lastname: Hirata
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Ikedo
authors.forename: Chie
authors.initials: C
authors.lastname: Horinouchi
authors.forename: Michiko
authors.initials: M
authors.lastname: Noguchi
authors.forename: Shingo
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Shun-Ichi
authors.initials: S
authors.lastname: Nagata
authors.forename: Seiji
authors.initials: S
authors.lastname: Hobo
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D001992:Bronchoalveolar Lavage Fluid; D002417:Cattle; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000493:pharmacokinetics*; D008168:Lung / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D000077422:Enrofloxacin