title: Angiotensin II analogs comprised of Pro-Amb (γ-turn scaffold) as angiotensin II type 2 (AT(2)) receptor agonists.
abstract: We describe herein the design, synthesis and conformational investigation of Pro-Amb (proline-3-amino-2-methoxybenzoic acid) incorporated Angiotensin II and its truncated analogues. Solution-state NMR and CD studies suggest γ-turn-like conformation in Pro-Amb analogs in aqueous solution. Furthermore, Pro-Amb analogs have been shown to act as AT2 receptor agonists.
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, Maharashtra, India. gj.sanjayan@ncl.res.in.
authors.forename: Ganesh S
authors.initials: GS
authors.lastname: Jedhe
authors.forename: Amol S
authors.initials: AS
authors.lastname: Kotmale
authors.forename: Pattuparambil R
authors.initials: PR
authors.lastname: Rajamohanan
authors.forename: Santosh
authors.initials: S
authors.lastname: Pasha
authors.forename: Gangadhar J
authors.initials: GJ
authors.lastname: Sanjayan
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D044139:Receptor, Angiotensin, Type 2 / Q000819:agonists* / Q000737:chemistry
chemical_list: D044139:Receptor, Angiotensin, Type 2; D000804:Angiotensin II