title: Cytotoxic Cytochalasins and Other Metabolites from Xylariaceae sp. FL0390, a Fungal Endophyte of Spanish Moss.
abstract: Two new metabolites, 6-oxo-12-norcytochalasin D (1) and 4,5-di-isobutyl-2(1H)-pyrimidinone (2), together with seven known metabolites, cytochalasins D (3), Q (4), and N (5), 12-hydroxyzygosporin G (6), heptelidic acid chlorohydrin (7), (+)-heptelidic acid (8), and trichoderonic acid A (9), were isolated from Xylariaceae sp. FL0390, a fungal endophyte inhabiting Spanish moss, Tillandsia usneoides. Metabolite 1 is the first example of a 12-norcytochalasin. All metabolites, except 2 and 9, showed cytotoxic activity in a panel of five human tumor cell lines with IC50S of 0.2-5.0 μM.
authors.forename: Ya-Ming
authors.initials: YM
authors.lastname: Xu
authors.forename: Bharat P
authors.initials: BP
authors.lastname: Bashyal
authors.forename: Mangping X
authors.initials: MX
authors.lastname: Liu
authors.forename: Patricia
authors.initials: P
authors.lastname: Espinosa-Artiles
authors.forename: Jana M
authors.initials: JM
authors.lastname: U'Ren
authors.forename: A Elizabeth
authors.initials: AE
authors.lastname: Arnold
authors.forename: A A Leslie
authors.initials: AA
authors.lastname: Gunatilaka
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D003572:Cytochalasins / Q000737:chemistry / Q000494:pharmacology*; D060026:Endophytes / Q000737:chemistry*; D015394:Molecular Structure; D031232:Tillandsia / Q000382:microbiology*
chemical_list: D000970:Antineoplastic Agents; D003572:Cytochalasins