title: Evaluation of antimicrobial properties of bioactive glass used in regenerative periodontal therapy.
abstract: BACKGROUND
  Bone grafting materials which have an inherent anti-microbial property against initial colonizers of plaque bacteria would be useful in regenerative periodontal surgical procedures.
  
  
  OBJECTIVE
  This study was performed to analyze the antibacterial property of a Perioglas™ against a common oral commensal Streptococcus salivarius (early colonizer).
  
  
  METHODS
  In vitro observational study.
  
  
  METHODS
  Perioglas™ (in various concentrations) was assessed for its antibacterial property against the ATCC 13419 strain of S. salivarius. The anti-microbial activity was analyzed in terms of reduction in colony-forming units in culture plates and smear following a 24 h incubation at 37°C.
  
  
  METHODS
  Observational study - No statistical analysis applicable.
  
  
  RESULTS
  The bioactive glass (BAG) exerted an antibacterial effect against the S. salivarius in the suspending media and smear. The antibacterial activity of BAG increased in proportion with its concentration.
  
  
  CONCLUSIONS
  Perioglas™ demonstrated a considerable antibacterial effect against S. salivarius at 50 mg/mL concentration.
authors.affiliation: Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra University, Chennai, Tamil Nadu, India.
authors.forename: Ram Sabarish
authors.initials: RS
authors.lastname: Chandrasekar
authors.affiliation: Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra University, Chennai, Tamil Nadu, India.
authors.forename: Vamsi
authors.initials: V
authors.lastname: Lavu
authors.affiliation: Department of Microbiology, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.
authors.forename: Kennedy
authors.initials: K
authors.lastname: Kumar
authors.affiliation: Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra University, Chennai, Tamil Nadu, India.
authors.forename: Suresh Ranga
authors.initials: SR
authors.lastname: Rao
keywords: Antibacterial agents; bioactive glass 45S5; bone grafting