title: Variation at NRG1 genotype related to modulation of small-world properties of the functional cortical network.
abstract: Functional brain networks possess significant small-world (SW) properties. Genetic variation relevant to both inhibitory and excitatory transmission may contribute to modulate these properties. In healthy controls, genotypic variation in Neuregulin 1 (NRG1) related to the risk of psychosis (risk alleles) would contribute to functional SW modulation of the cortical network. Electroencephalographic activity during an odd-ball task was recorded in 144 healthy controls. Then, small-worldness (SWn) was calculated in five frequency bands (i.e., theta, alpha, beta1, beta2 and gamma) for baseline (from -300 to the stimulus onset) and response (150-450 ms post-target stimulus) windows. The SWn modulation was defined as the difference in SWn between both windows. Association between SWn modulation and carrying the risk allele for three single nucleotide polymorphisms (SNP) of NRG1 (i.e., rs6468119, rs6994992 and rs7005606) was assessed. A significant association between three SNPs of NRG1 and the SWn modulation was found, specifically: NRG1 rs6468119 in alpha and beta1 bands; NRG1 rs6994992 in theta band; and NRG1 rs7005606 in theta and beta1 bands. Genetic variation at NRG1 may influence functional brain connectivity through the modulation of SWn properties of the cortical network.
authors.affiliation: Psychiatry Department, Faculty of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005, Valladolid, Spain.
authors.forename: Alba
authors.initials: A
authors.lastname: Lubeiro
authors.affiliation: Biomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, University of Valladolid, Paseo de Belén, 15, 47011, Valladolid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Gomez-Pilar
authors.affiliation: Psychiatry Department, Faculty of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005, Valladolid, Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: Martín
authors.affiliation: Neurotek, Neurosciences Department, Achucarro Basque Center for Neurosciences, University of the Basque Country, 48170, Zamudio, Vizcaya, Spain.
authors.forename: Aitor
authors.initials: A
authors.lastname: Palomino
authors.affiliation: Psychiatry Department, Hospital Universitario de Álava, Jose Atxotegi, s/n, 01009, Vitoria-Gasteiz, Álava, Spain.
authors.forename: Myriam
authors.initials: M
authors.lastname: Fernández
authors.affiliation: Psychiatry Department, Hospital Universitario de Álava, Jose Atxotegi, s/n, 01009, Vitoria-Gasteiz, Álava, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: González-Pinto
authors.affiliation: Biomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, University of Valladolid, Paseo de Belén, 15, 47011, Valladolid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Poza
authors.affiliation: Biomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, University of Valladolid, Paseo de Belén, 15, 47011, Valladolid, Spain.
authors.forename: Roberto
authors.initials: R
authors.lastname: Hornero
authors.affiliation: Psychiatry Department, Faculty of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005, Valladolid, Spain. vicente.molina@uva.es.
authors.forename: Vicente
authors.initials: V
authors.lastname: Molina
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D001931:Brain Mapping; D058256:Brain Waves / Q000235:genetics*; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D005820:Genetic Testing; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D020890:Neuregulin-1 / Q000235:genetics*; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D058067:Wavelet Analysis; D055815:Young Adult
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; C094131:NRG1 protein, human; D020890:Neuregulin-1; C544528:briakinumab
keywords: Imaging genetics; NRG1; Neuroimaging; Psychosis; Small-world