title: The Assessment of the Readiness of Molecular Biomarker-Based Mobile Health Technologies for Healthcare Applications.
abstract: Mobile health technologies to detect physiological and simple-analyte biomarkers have been explored for the improvement and cost-reduction of healthcare services, some of which have been endorsed by the US FDA. Advancements in the investigations of non-invasive and minimally-invasive molecular biomarkers and biomarker candidates and the development of portable biomarker detection technologies have fuelled great interests in these new technologies for mhealth applications. But apart from the development of more portable biomarker detection technologies, key questions need to be answered and resolved regarding to the relevance, coverage, and performance of these technologies and the big data management issues arising from their wide spread applications. In this work, we analyzed the newly emerging portable biomarker detection technologies, the 664 non-invasive molecular biomarkers and the 592 potential minimally-invasive blood molecular biomarkers, focusing on their detection capability, affordability, relevance, and coverage. Our analysis suggests that a substantial percentage of these biomarkers together with the new technologies can be potentially used for a variety of disease conditions in mhealth applications. We further propose a new strategy for reducing the workload in the processing and analysis of the big data arising from widespread use of mhealth products, and discuss potential issues of implementing this strategy.
authors.affiliation: Shenzhen Kivita Innovative Drug Discovery Institute, and the Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China.|Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543 Singapore.|NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 117456, Singapore.
authors.forename: Chu
authors.initials: C
authors.lastname: Qin
authors.affiliation: Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543 Singapore.|NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 117456, Singapore.
authors.forename: Lin
authors.initials: L
authors.lastname: Tao
authors.affiliation: Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543 Singapore.
authors.forename: Yik Hui
authors.initials: YH
authors.lastname: Phang
authors.affiliation: Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543 Singapore.|Computation and Systems Biology, Singapore-MIT Alliance, National University of Singapore, Singapore.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543 Singapore.
authors.forename: Shang Ying
authors.initials: SY
authors.lastname: Chen
authors.affiliation: Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543 Singapore.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Shenzhen Kivita Innovative Drug Discovery Institute, and the Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Shenzhen Kivita Innovative Drug Discovery Institute, and the Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China.
authors.forename: Yu Yang
authors.initials: YY
authors.lastname: Jiang
authors.affiliation: Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543 Singapore.
authors.forename: Yu Zong
authors.initials: YZ
authors.lastname: Chen
mesh_terms: D015415:Biomarkers; D020811:Biomedical Technology; D003695:Delivery of Health Care / Q000379:methods; D019468:Disease Management; D001330:Electronic Data Processing; D006801:Humans; D008403:Mass Screening; D025202:Molecular Diagnostic Techniques; D057285:Precision Medicine; D011379:Prognosis; D017216:Telemedicine / Q000379:methods*
chemical_list: D015415:Biomarkers