title: Sirtuins-mediators of maternal obesity-induced complications in offspring?
abstract: Obesity is a complex metabolic disease, attributed to diverse and interactive genetic and environmental factors. The associated health consequences of obesity are pleiotropic, with individuals being more susceptible to chronic diseases such as type 2 diabetes mellitus, hypertension, and lipotoxicity-related chronic diseases. The contribution of maternal obesity to the offspring's predisposition to both obesity and its complications is increasingly recognized. Understanding the mechanisms underlying these "transmissible" effects is critical to develop therapeutic interventions to reduce the risk for "programmed" obesity. Sirtuins (SIRTs), particularly SIRT1 and SIRT3, are NAD(+)-dependent deacetylases that regulate metabolic balance and stress responses in both central and peripheral tissues, of which dysregulation is a well-established mediator for the development and effects of obesity. Nevertheless, their implication in the transmissible effects of maternal obesity across generations remains largely elusive. In this review, we examine multiple pathways and systems that are likely to mediate such effects, with particular emphasis on the role of SIRTs.-Nguyen, L. T., Chen, H., Pollock, C. A., Saad, S. Sirtuins-mediators of maternal obesity-induced complications in offspring?
authors.affiliation: *Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia; and School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia lngu8923@uni.sydney.edu.au.
authors.forename: Long T
authors.initials: LT
authors.lastname: Nguyen
authors.affiliation: *Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia; and School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: *Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia; and School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia.
authors.forename: Carol A
authors.initials: CA
authors.lastname: Pollock
authors.affiliation: *Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia; and School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia.
authors.forename: Sonia
authors.initials: S
authors.lastname: Saad
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D039382:Maternal Nutritional Physiological Phenomena; D008954:Models, Biological; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism / Q000503:physiopathology*; D015398:Signal Transduction; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D037761:Sirtuins
keywords: chronic diseases; fetal programming; metabolism