title: ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease.
abstract: Alzheimer's disease (AD) is the most common cause of dementia with no cure at present. Cholesterol metabolism is closely associated with AD at several stages. ACAT1 converts free cholesterol to cholesteryl esters, and plays important roles in cellular cholesterol homeostasis. Recent studies show that in a mouse model, blocking ACAT1 provides multiple beneficial effects on AD. Here we review the current evidence that implicates ACAT1 as a therapeutic target for AD. We also discuss the potential usage of various ACAT inhibitors currently available to treat AD.
authors.affiliation: Department of Biochemistry, Geisel School of Medicine at Dartmouth, 304 Vail Building, Hanover, NH 03755, USA.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Shibuya
authors.affiliation: Department of Biochemistry, Geisel School of Medicine at Dartmouth, 304 Vail Building, Hanover, NH 03755, USA.
authors.forename: Catherine Cy
authors.initials: CC
authors.lastname: Chang
authors.affiliation: Department of Biochemistry, Geisel School of Medicine at Dartmouth, 304 Vail Building, Hanover, NH 03755, USA.
authors.forename: Ta-Yuan
authors.initials: TY
authors.lastname: Chang
mesh_terms: D000101:Acetyl-CoA C-Acetyltransferase / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D002785:Sterol O-Acyltransferase; C493492:sterol O-acyltransferase 1; C506639:ACAT1 protein, human; C506641:Acat1 protein, mouse; D000101:Acetyl-CoA C-Acetyltransferase