title: [Progress of new-generation genome editing mediated by engineered endonucleases].
abstract: Genome editing refers to the experimental methods to targeted modify specific loci in the genomic DNA sequence. In recent years, engineered endonucleases, including ZFN, TALEN and CRISPR/Cas, have been developed as a new-generation genome editing technique, and greatly improved the feasibility of gene function analyses, gene therapy, etc. Here, we briefly summarize the basic principle, developmental process and applications of this technology.
authors.forename: An
authors.initials: A
authors.lastname: Xiao
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
mesh_terms: D064112:Clustered Regularly Interspaced Short Palindromic Repeats; D004720:Endonucleases / Q000235:genetics*; D005818:Genetic Engineering / Q000379:methods*; D015316:Genetic Therapy; D016678:Genome; D023281:Genomics
chemical_list: D004720:Endonucleases