title: Nanoparticle systems reduce systemic toxicity in cancer treatment.
authors.affiliation: Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.|Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.|Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Hai
authors.initials: H
authors.lastname: Wang
authors.affiliation: Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.|Division of Hematology, Department of Internal medicine, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Xiongbin
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.|Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.|Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: He
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D053769:Nanocapsules / Q000737:chemistry*; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D053769:Nanocapsules
keywords: EPR effect; cancer stem cells; co-delivery; combination therapy; immunotherapy; stimuli responsiveness; targeted delivery; theranostics; tumor microenvironment