title: SYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL AND PHYTOTOXIC SCREENING OF 1-AROYL-3,5-DIARYLPYRAZOLINE DERIVATIVES.
abstract: Pyrazolines are biologically and pharmaceutically very active scaffolds. Derivatives of. (3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)(phenyl)methanone were synthesized by the cyclization of chalcones (1a-c) with substituted benzyl hydrazides (2a-e) using a few drops of piperidine as catalyst. Structures of all the synthesized compounds were confirmed by FTIR, 1H NMR, 13C NMR and mass spectrometric analysis. All the pyrazolines were subjected to antimicrobial and phytotoxic assays. Compound 3a and 3c showed maximum antimicrobial activities while all the synthesized compounds were active acc. to their phytotoxic assays.
authors.forename: Amara
authors.initials: A
authors.lastname: Mumtaz
authors.forename: Aamer
authors.initials: A
authors.lastname: Saeed
authors.forename: Aneela
authors.initials: A
authors.lastname: Maalik
authors.forename: Wajiha
authors.initials: W
authors.lastname: Khan
authors.forename: Saira
authors.initials: S
authors.lastname: Azhar
authors.forename: Nighat
authors.initials: N
authors.lastname: Fatima
authors.forename: Asma
authors.initials: A
authors.lastname: Zaidi
authors.forename: Muhammad
authors.initials: M
authors.lastname: Atif
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D010944:Plants / Q000187:drug effects*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000890:Anti-Infective Agents; D011720:Pyrazoles