title: In vivo contact biomechanics in the trapeziometacarpal joint using finite deformation biphasic theory and mathematical modelling.
abstract: The assessment of the contact biomechanics in the trapeziometacarpal (TMC) joint during functional tasks represents a relevant way to obtain a better understanding of the onset of osteoarthritis (OA). CT scans of the hand region of 20 female volunteers were taken in relaxed neutral, lateral key pinch and power grasp configuration. 3D models of the first metacarpal (MC1) and the trapezium were created. The articular area of each bone was quantified and a mathematical model was developed in Matlab to evaluate the projected contact area and stress distribution of each bone. The articular areas of the MC1 and the trapezium presented no significant difference. A slightly smaller projected contact area was calculated for the trapezium compared to the MC1. Similar amounts of stress were reported in the neutral and lateral pinch configurations. The highest stress levels were observed during power grasp. Very consistent results for high stress location on the volar/radial articular sub-region were found in the neutral and power grasp configurations. More variation was reported during lateral pinch. The mathematical model presented in this paper offers the possibility to predict contact patterns within the TMC joint based on in vivo CT images.
authors.affiliation: KU Leuven, Department of Development & Regeneration @ Kulak, Etienne Sabbelaan 53, 8500 Kortrijk, Belgium. Electronic address: benjamin.dourthe@kuleuven-kulak.be.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Dourthe
authors.affiliation: KU Leuven, Department of Development & Regeneration @ Kulak, Etienne Sabbelaan 53, 8500 Kortrijk, Belgium.
authors.forename: Priscilla
authors.initials: P
authors.lastname: D'Agostino
authors.affiliation: KU Leuven, Department of Development & Regeneration @ Kulak, Etienne Sabbelaan 53, 8500 Kortrijk, Belgium; AZ Groeninge, Campus Loofstraat, Loofstraat 43, 8500 Kortrijk, Belgium.
authors.forename: Filip
authors.initials: F
authors.lastname: Stockmans
authors.affiliation: KU Leuven, Department of Development & Regeneration @ Kulak, Etienne Sabbelaan 53, 8500 Kortrijk, Belgium.
authors.forename: Faes
authors.initials: F
authors.lastname: Kerkhof
authors.affiliation: KU Leuven, Department of Development & Regeneration @ Kulak, Etienne Sabbelaan 53, 8500 Kortrijk, Belgium.
authors.forename: Evie
authors.initials: E
authors.lastname: Vereecke
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001696:Biomechanical Phenomena; D052737:Carpometacarpal Joints / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D055595:Mechanical Phenomena; D008875:Middle Aged; D008954:Models, Biological; D008962:Models, Theoretical; D013314:Stress, Mechanical; D014057:Tomography, X-Ray Computed
keywords: Biomechanics; Cartillage; Contact patterns; Mathematical modelling; Medical imaging; Osteoarthritis; TMC joint; Trapeziometacarpal joint; in vivo