title: Multi-voxel magnetic resonance spectroscopy of cerebral metabolites in healthy dogs at 1.5 Tesla.
abstract: This study was conducted to measure the difference in levels of cerebral metabolites in the right and left hemispheres, gray (GM) and white matter (WM), imaging planes, and anatomical regions of healthy dogs to establish normal variations. Eight male Beagle dogs (1 to 4 years of age; mean age, 2 years) with no evidence of neurologic disease were studied. Using the multi-voxel technique on a 1.5 Tesla magnetic resonance imaging scanner, metabolite values (N-acetyl aspartate [NAA], choline [Cho], creatine [Cr]) were obtained from the frontoparietal WM, parietal GM, temporal GM, occipital GM, thalamus, cerebellum, mid-brain, and pons. There was no significant difference in levels of these metabolites between the right and left in any locations or between the GM and WM in the cerebral hemispheres. However, there were significant differences in metabolite ratios within imaging planes. The NAA/Cr was lower in the cerebellum than other regions and the thalamus had a higher Cho/Cr and lower NAA/Cho ratio than in other regions. The spectral and metabolic values will provide a useful internal reference for clinical practice and research involving multi-voxel magnetic resonance spectroscopy. Measurement of metabolite values in the transverse plane is recommended for comparing levels of regional metabolites.
authors.affiliation: Ian Animal Diagnostic Center, Seoul 06014, Korea.
authors.forename: Sooyoung
authors.initials: S
authors.lastname: Choi
authors.affiliation: Ian Animal Diagnostic Center, Seoul 06014, Korea.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Song
authors.affiliation: College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
authors.forename: Kija
authors.initials: K
authors.lastname: Lee
authors.affiliation: College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.
authors.forename: Youngwon
authors.initials: Y
authors.lastname: Lee
authors.affiliation: College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.
authors.forename: Hojung
authors.initials: H
authors.lastname: Choi
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D054022:Cerebrum / Q000378:metabolism*; D002794:Choline / Q000378:metabolism*; D003401:Creatine / Q000378:metabolism*; D004285:Dogs / Q000378:metabolism; D066128:Gray Matter / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D012016:Reference Values; D066127:White Matter / Q000378:metabolism
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline
keywords: cerebrum; dog; magnetic resonance spectroscopy