title: Signal Transduction: Gain of Activin Turns Muscle into Bone.
abstract: Recent data provide an unexpected twist in our understanding of the pathogenesis of fibrodysplasia ossificans progressiva. Surprisingly, the causative amino acid mutation of the BMP receptor responds to activin, thereby turning soft tissues into bone.
authors.affiliation: Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center, The Netherlands.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Sanchez-Duffhues
authors.affiliation: Department of Biomedical Research, Institute of Molecular Biology & Biotechnology, FORTH & Laboratory of Biological Chemistry, Medical School, University of Ioannina, University Campus, University of Ioannina, 45110 Ioannina, Greece. Currently: Visiting Professor, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
authors.forename: Theodore
authors.initials: T
authors.lastname: Fotsis
authors.affiliation: Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center, The Netherlands. Electronic address: P.ten_Dijke@lumc.nl.
authors.forename: Peter
authors.initials: P
authors.lastname: ten Dijke
mesh_terms: D030201:Activin Receptors, Type I / Q000235:genetics*; D028341:Activins / Q000378:metabolism*; D000818:Animals; D009154:Mutation; D009221:Myositis Ossificans / Q000235:genetics*
chemical_list: D028341:Activins; D030201:Activin Receptors, Type I