title: Black Rice with Giant Embryo Attenuates Obesity-Associated Metabolic Disorders in ob/ob Mice.
abstract: Obesity is closely associated with metabolic disorders such as hyperglycemia and dyslipidemia. Leptin-deficient ob/ob mice (C57BL/6J-ob/ob) and C57BL/6J mice were randomly assigned to a diet of black rice with giant embryo (BR), white rice (WR), or AIN-93G (control) and pair-fed for 14 weeks. Although there was no significant difference in body weight, BR-fed ob/ob mice had (1) significantly lower body fat mass than WR- and control-fed ob/ob mice determined by dual-energy X-ray absorptiometry; (2) significantly lower blood glucose, serum insulin, and triacylglycerol levels than control-fed ob/ob mice; and (3) significantly lower liver weight, hepatic triacylglycerol, and hepatic lipid droplets than both WR- and control-fed ob/ob mice. Furthermore, DNA damage in the liver, determined by phosphorylated H2AX protein, and in the kidney, determined by single-cell gel electrophoresis, was significantly lower in BR-fed than WR- and control-fed ob/ob mice. This study indicates that BR ameliorates obesity and its related metabolic disorders.
authors.affiliation: Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University , Chungju-si, South Korea.
authors.forename: Yoon-Mi
authors.initials: YM
authors.lastname: Lee
authors.affiliation: National Institute of Crop Science, Rural Development Administration , Miryang-si, South Korea.
authors.forename: Sank-Ik
authors.initials: SI
authors.lastname: Han
authors.affiliation: Department of Biomedical Chemistry, College of Biomedical and Health Sciences, Konkuk University , Chungju-si, South Korea.
authors.forename: Yu-Jin
authors.initials: YJ
authors.lastname: Won
authors.affiliation: Department of Food and Nutrition, Kyungnam University , Changwon, South Korea.
authors.forename: Eunji
authors.initials: E
authors.lastname: Lee
authors.affiliation: Department of Food and Nutrition, Kyungnam University , Changwon, South Korea.
authors.forename: Eunju
authors.initials: E
authors.lastname: Park
authors.affiliation: Department of Biomedical Laboratory Science, College of Health and Medical Science, Daejeon University , Daejeon-si, South Korea.
authors.forename: Seock-Yeon
authors.initials: SY
authors.lastname: Hwang
authors.affiliation: Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University , Chungju-si, South Korea.
authors.forename: Kyung-Jin
authors.initials: KJ
authors.lastname: Yeum
mesh_terms: D000818:Animals; D004032:Diet; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D020738:Leptin / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008659:Metabolic Diseases / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000378:metabolism*; D012275:Oryza / Q000737:chemistry*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D020738:Leptin; D014280:Triglycerides
keywords: DNA damage; black rice with giant embryo; fatty liver; metabolic disorders; obesity