title: [A experiment research of beryllium oxide induced oxidative lung injury and the protective effects of LBP in rats].
abstract: OBJECTIVE
  To explore beryllium oxide induced oxidative lung injury and the protective effects of LBP.
  
  
  METHODS
  Intoxication of animals were induced by once intratracheal injection and LBP intervention by intragastric administration. The content of HIF-1, VEGF and HO-1 of lung tissues were measured by kits. The pathological changes of lung tissue were showed by pathological section. The changes of lung ultrastructure were observed by electron microscope.
  
  
  RESULTS
  Pathological changes of the lung tissue in beryllium oxide exposure group rats were in line with the characteristics of beryllium disease in human. Compared with the control group, HO-1 was increased in beryllium oxide exposure 40 d group and low doses of LBP group, compared with the control group, HO-1 was increased in beryllium oxide exposure 80d group and LBP treatment groups (P < 0.05 or P < 0.01). Compared with the control group, HIF-1 was increased in beryllium oxide exposure 40 d group, LBP treatment groups, beryllium oxide exposure 60 d and 80 d groups (P < 0.05 or P < 0.01). Compared with the control group, VEGF was increased of all phases, especially in beryllium oxide exposure 40d and 80 groups, LBP treatment groups and beryllium oxide exposure 60 d (P < 0.05 or P < 0.01). The content of HO-1 of beryllium oxide exposure group was higher than the LBP treatment for 40d group but below LBP treatment for 80 d group (P < 0.05). The content of HIF1 of beryllium oxide exposure group was higher than high dose of LBP treatment for 60d group and LBP treatment for 80 d group (P < 0.01). The content of VEGF of beryllium oxide exposure group was higher than LBP treatment for 40 d group and high dose of LBP treatment for 60 d (P < 0.05 or P < 0.01).
  
  
  CONCLUSIONS
  BeO can cause abnormal expression of related genes of lung tissue in rats, LBP has protective effects on BeO caused lung injury.
authors.affiliation: School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 70004, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Liu
authors.affiliation: School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 70004, China.
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 70004, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 70004, China.
authors.forename: Conghui
authors.initials: C
authors.lastname: Wei
authors.affiliation: School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 70004, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yan
authors.affiliation: School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 70004, China.
authors.forename: Aihong
authors.initials: A
authors.lastname: Gong
authors.affiliation: School of Public Health, Ningxia Medical University, Yinchuan, Ningxia 70004, China; E-mail: guo@maili.xjtu.edu.cn.
authors.forename: Xiong
authors.initials: X
authors.lastname: Guo
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced / Q000503:physiopathology*; D000209:Acute-Phase Proteins / Q000494:pharmacology*; D000818:Animals; D001608:Beryllium / Q000633:toxicity*; D002352:Carrier Proteins / Q000494:pharmacology*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008562:Membrane Glycoproteins / Q000494:pharmacology*; D018384:Oxidative Stress; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D000099231:Lipopolysaccharide-Binding Protein
chemical_list: D000209:Acute-Phase Proteins; D001608:Beryllium; D002352:Carrier Proteins; D006419:Heme Oxygenase (Decyclizing); D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008562:Membrane Glycoproteins; D020011:Protective Agents; D042461:Vascular Endothelial Growth Factor A; D000099231:Lipopolysaccharide-Binding Protein; C497444:Hif1a protein, rat; C467498:vascular endothelial growth factor A, rat; C032777:beryllium oxide; C491523:Hmox1 protein, rat