title: Efficient Diethylzinc/Gallic Acid and Diethylzinc/Gallic Acid Ester Catalytic Systems for the Ring-Opening Polymerization of rac-Lactide.
abstract: Polylactide (PLA) represents one of the most promising biomedical polymers due to its biodegradability, bioresorbability and good biocompatibility. This work highlights the synthesis and characterization of PLAs using novel diethylzinc/gallic acid (ZnEt₂/GAc) and diethylzinc/propyl gallate (ZnEt₂/PGAc) catalytic systems that are safe for human body. The results of the ring-opening polymerization (ROP) of rac-lactide (rac-LA) in the presence of zinc-based catalytic systems have shown that, depending on the reaction conditions, "predominantly isotactic", disyndiotactic or atactic PLA can be obtained. Therefore, the controlled and stereoselective ROP of rac-LA is discussed in detail in this paper.
authors.affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy and Division of Laboratory Medicine, Medical University of Warsaw, 1 Banacha St., Warsaw 02-097, Poland. karolina_zoltowska@o2.pl.
authors.forename: Karolina
authors.initials: K
authors.lastname: Żółtowska
authors.affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy and Division of Laboratory Medicine, Medical University of Warsaw, 1 Banacha St., Warsaw 02-097, Poland. piotrowska_urszula@wp.pl.
authors.forename: Urszula
authors.initials: U
authors.lastname: Piotrowska
authors.affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy and Division of Laboratory Medicine, Medical University of Warsaw, 1 Banacha St., Warsaw 02-097, Poland. eoledzka@wp.pl.
authors.forename: Ewa
authors.initials: E
authors.lastname: Oledzka
authors.affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy and Division of Laboratory Medicine, Medical University of Warsaw, 1 Banacha St., Warsaw 02-097, Poland. marcin.sobczak@wp.pl.|Department of Organic Chemistry, Faculty of Materials Science and Design, Kazimierz Pulaski University of Technology and Humanities in Radom, Ul. Chrobrego 27, Radom 26-600, Poland. marcin.sobczak@wp.pl.
authors.forename: Marcin
authors.initials: M
authors.lastname: Sobczak
mesh_terms: D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004952:Esters / Q000737:chemistry*; D005707:Gallic Acid / Q000737:chemistry*; D006801:Humans; D009942:Organometallic Compounds / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D004952:Esters; D009942:Organometallic Compounds; D011091:Polyesters; D011108:Polymers; C033616:poly(lactide); D005707:Gallic Acid; C454811:diethylzinc
keywords: biomedical polymers; gallic acid; polylactide; propyl gallate; ring-opening polymerization; zinc-based catalysts