title: A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method.
abstract: An efficient grinding protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives from acetylene ester, hydrazine hydrate, aryl aldehydes and malononitrile under solvent free conditions has been achieved with excellent yields. The structures of the synthesized compounds were deduced by spectroscopic techniques and the compounds were further evaluated for their in vitro antioxidant and antimicrobial activities.
authors.affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India.
authors.forename: Sethurajan
authors.initials: S
authors.lastname: Ambethkar
authors.affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India.
authors.forename: Vediappen
authors.initials: V
authors.lastname: Padmini
authors.affiliation: X-ray Diffraction Laboratory, Department of Chemistry, Texas A&M University, College Station, TX 77842, USA.
authors.forename: Nattamai
authors.initials: N
authors.lastname: Bhuvanesh
keywords: Antimicrobial; Antioxidant; Grinding; Multicomponent; Pyranopyrazole