title: Role of Exercise-Induced Oxidative Stress in Sickle Cell Trait and Disease.
abstract: Sickle cell disease is a class of hemoglobinopathy in humans, which is the most common inherited disease in the world. Although complications of sickle cell disease start from polymerization of red blood cells during its deoxygenating phase, the oxidative stress resulting from the biological processes associated with this disease (ischaemic and hypoxic injuries, hemolysis and inflammation) has been shown to contribute to its pathophysiology. It is widely known that chronic exercise reduces oxidative stress in healthy people, mainly via improvement of antioxidant enzyme efficiency. In addition, recent studies in other diseases, as well as in sickle cell trait carriers and in a mouse model of sickle cell disease, have shown that regular physical activity could decrease oxidative stress. The purpose of this review is to summarize the role of oxidative stress in sickle cell disease and the effects of acute and chronic exercise on the pro-oxidant/antioxidant balance in sickle cell trait and sickle cell disease.
authors.affiliation: EA 647 Centre de Recherche et d'Innovation sur le Sport, Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne, France.|Cardiovascular, Metabolism, Diabetes, and Nutrition (CarMeN INSERM U-1060), Faculty of Medicine Lyon Sud, Université Claude Bernard Lyon 1, Oullins, France.
authors.forename: Erica N
authors.initials: EN
authors.lastname: Chirico
authors.affiliation: EA 647 Centre de Recherche et d'Innovation sur le Sport, Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne, France.|Laboratory of Excellence in Red Blood Cell (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Faës
authors.affiliation: EA 647 Centre de Recherche et d'Innovation sur le Sport, Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne, France.|Laboratory of Excellence in Red Blood Cell (LABEX GR-Ex), PRES Sorbonne, Paris, France.|Institut Universitaire de France, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Connes
authors.affiliation: Cardiovascular, Metabolism, Diabetes, and Nutrition (CarMeN INSERM U-1060), Faculty of Medicine Lyon Sud, Université Claude Bernard Lyon 1, Oullins, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Canet-Soulas
authors.affiliation: EA 647 Centre de Recherche et d'Innovation sur le Sport, Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne, France.|Laboratory of Excellence in Red Blood Cell (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Martin
authors.affiliation: EA 647 Centre de Recherche et d'Innovation sur le Sport, Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne, France. vincent.pialoux@univ-lyon1.fr.|Laboratory of Excellence in Red Blood Cell (LABEX GR-Ex), PRES Sorbonne, Paris, France. vincent.pialoux@univ-lyon1.fr.|Institut Universitaire de France, Paris, France. vincent.pialoux@univ-lyon1.fr.
authors.forename: Vincent
authors.initials: V
authors.lastname: Pialoux
mesh_terms: D000755:Anemia, Sickle Cell / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D015444:Exercise / Q000502:physiology*; D006418:Heme / Q000378:metabolism; D006451:Hemoglobin, Sickle / Q000378:metabolism; D006461:Hemolysis; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D007501:Iron / Q000097:blood; D051379:Mice; D019255:NADPH Oxidases / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D015427:Reperfusion Injury / Q000378:metabolism; D012805:Sickle Cell Trait / Q000378:metabolism*; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D006451:Hemoglobin, Sickle; D009569:Nitric Oxide; D006418:Heme; D007501:Iron; D014969:Xanthine Oxidase; D019255:NADPH Oxidases