title: 19-Tungstodiarsenate(III) Functionalized by Organoantimony(III) Groups: Tuning the Structure-Bioactivity Relationship.
abstract: A family of three discrete organoantimony(III)-functionalized heteropolyanions-[Na{2-(Me2HN(+)CH2)C6H4Sb(III)}As(III)2W19O67(H2O)](10-) (1), [{2-(Me2HN(+)CH2)C6H4Sb(III)}2As(III)2W19O67(H2O)](8-) (2), and [{2-(Me2HN(+)CH2)C6H4Sb(III)}{WO2(H2O)}{WO(H2O)}2(B-β-As(III)W8O30)(B-α-As(III)W9O33)2](14-) (3)-have been prepared by one-pot reactions of the 19-tungstodiarsenate(III) precursor [As(III)2W19O67(H2O)](14-) with 2-(Me2NCH2)C6H4SbCl2. The three novel polyanions crystallized as the hydrated mixed-alkali salts Cs3KNa6[Na{2-(Me2HN(+)CH2)C6H4Sb(III)}As(III)2W19O67(H2O)]·43H2O (CsKNa-1), Rb2.5K5.5[{2-(Me2HN(+)CH2)C6H4Sb(III)}2As(III)2W19O67(H2O)]·18H2O·Me2NCH2C6H5 (RbK-2), and Rb2.5K11.5[{2-(Me2HN(+)CH2)C6H4Sb(III)}{WO2(H2O)}{WO(H2O)}2(B-β-As(III)W8O30)(B-α-As(III)W9O33)2]·52H2O (RbK-3), respectively. The number of incorporated {2-(Me2HN(+)CH2)C6H4Sb(III)} units could be tuned by careful control of the experimental parameters. Polyanions 1 and 2 possess a dimeric sandwich-type topology, whereas 3 features a trimeric, wheel-shaped structure, representing the largest organoantimony-containing polyanion. All three compounds were fully characterized in the solid state via single-crystal X-ray diffraction (XRD), infrared (IR) spectroscopy, and thermogravimetric analysis, and their aqueous solution stability was validated by ultraviolet-visible light (UV-vis) and multinuclear ((1)H, (13)C, and (183)W) nuclear magnetic resonance (NMR) spectroscopy. Effective inhibition against six different types of bacteria was observed for 1 and 2, and we could extract a structure-bioactivity relationship for these polyanions.
authors.affiliation: Department of Life Sciences and Chemistry, Jacobs University , P.O. Box 750 561, 28725 Bremen, Germany.
authors.forename: Peng
authors.initials: P
authors.lastname: Yang
authors.affiliation: Department of Life Sciences and Chemistry, Jacobs University , P.O. Box 750 561, 28725 Bremen, Germany.
authors.forename: Zhengguo
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Department of Life Sciences and Chemistry, Jacobs University , P.O. Box 750 561, 28725 Bremen, Germany.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Alfaro-Espinoza
authors.affiliation: Department of Life Sciences and Chemistry, Jacobs University , P.O. Box 750 561, 28725 Bremen, Germany.
authors.forename: Matthias S
authors.initials: MS
authors.lastname: Ullrich
authors.affiliation: Department of Chemistry, Supramolecular Organic and Organometallic Chemistry Centre (SOOMCC), Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University , Arany Janos Str. 11, RO-400028 Cluj-Napoca, Romania.
authors.forename: Ciprian I
authors.initials: CI
authors.lastname: Raţ
authors.affiliation: Department of Chemistry, Supramolecular Organic and Organometallic Chemistry Centre (SOOMCC), Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University , Arany Janos Str. 11, RO-400028 Cluj-Napoca, Romania.
authors.forename: Cristian
authors.initials: C
authors.lastname: Silvestru
authors.affiliation: Department of Life Sciences and Chemistry, Jacobs University , P.O. Box 750 561, 28725 Bremen, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kortz
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000965:Antimony / Q000737:chemistry* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013818:Thermogravimetry; D017973:Tungsten Compounds / Q000737:chemistry* / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D017973:Tungsten Compounds; D000965:Antimony