title: Antidepressant or Antipsychotic Overdose in the Intensive Care Unit - Identification of Patients at Risk.
abstract: It is often advised that patients who have ingested an overdose of antidepressants (AD) or antipsychotics (AP) are monitored with continuous ECG for minimum of 12-24 hr. These patients are often observed in an ICU. Our aim was to identify the number of patients with AD and/or AP overdose without adverse signs at hospital admission that turned out to need intensive care treatment. The effect of the antidepressants overdose risk assessment (ADORA) system was evaluated in patients with antidepressant as well as antipsychotic overdose. Our hypothesis was that patients with low ADORA do not need intensive care treatment. This retrospective study was conducted in adult patients admitted to the ICU at Odense University Hospital after an overdose with AP and/or AD between 1 January 2009 and 1 September 2014. Patients with predefined adverse signs in the emergency department were excluded due to obvious need of intensive care. Of the 157 patients included, 12 patients (8%) developed events during the ICU stay. Only 3 patients received intubation, vasoactive drugs and/or dialysis. None developed ventricular dysrhythmias. There were no fatalities. All the patients with low-risk assessment by ADORA within the first 6 hr did not develop events within the first 24 hr after hospital admission. The vast majority of patients with AD and/or AP overdose and no adverse signs at admission did not require intensive care treatment. Low-risk ADORA identified patients with antidepressant as well as antipsychotic overdose who would not require initial intensive care treatment. This is the first time the ADORA system has been evaluated in patients with antidepressant as well as antipsychotic overdose.
authors.affiliation: Department of Anaesthesia and Intensive Care Medicine, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
authors.forename: Linda
authors.initials: L
authors.lastname: Borg
authors.affiliation: Department of Anaesthesia and Intensive Care Medicine, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
authors.forename: Anna
authors.initials: A
authors.lastname: Julkunen
authors.affiliation: Department of Anaesthesia and Intensive Care Medicine, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
authors.forename: Kristian
authors.initials: K
authors.lastname: Rørbaek Madsen
authors.affiliation: Department of Anaesthesia and Intensive Care Medicine, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Strøm
authors.affiliation: Department of Anaesthesia and Intensive Care Medicine, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
authors.forename: Palle
authors.initials: P
authors.lastname: Toft
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000097:blood / Q000506:poisoning*; D014150:Antipsychotic Agents / Q000097:blood / Q000506:poisoning*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology; D062787:Drug Overdose / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006760:Hospitalization; D006785:Hospitals, University; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents