title: Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value.
abstract: To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using hM4Di-DREADD (designer receptor exclusively activated by designer drug). Repeated inactivation reduced sensitivity to differences in reward size in two monkeys. These results suggest that retrieval of relative stimulus values from memory depends on the interaction between Rh and OFC.
authors.affiliation: Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland, USA.
authors.forename: Mark A G
authors.initials: MA
authors.lastname: Eldridge
authors.affiliation: Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland, USA.
authors.forename: Walter
authors.initials: W
authors.lastname: Lerchner
authors.affiliation: Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland, USA.
authors.forename: Richard C
authors.initials: RC
authors.lastname: Saunders
authors.affiliation: Department of Molecular Neuroimaging, National Institute of Radiological Science, Chiba, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kaneko
authors.affiliation: Laboratory of Metabolism, National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: Kristopher W
authors.initials: KW
authors.lastname: Krausz
authors.affiliation: Laboratory of Metabolism, National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: Frank J
authors.identifier: http://orcid.org/0000-0002-7990-2140
authors.initials: FJ
authors.lastname: Gonzalez
authors.affiliation: Department of Molecular Neuroimaging, National Institute of Radiological Science, Chiba, Japan.
authors.forename: Bin
authors.initials: B
authors.lastname: Ji
authors.affiliation: Department of Molecular Neuroimaging, National Institute of Radiological Science, Chiba, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Higuchi
authors.affiliation: Department of Molecular Neuroimaging, National Institute of Radiological Science, Chiba, Japan.
authors.forename: Takafumi
authors.identifier: http://orcid.org/0000-0003-4305-0174
authors.initials: T
authors.lastname: Minamimoto
authors.affiliation: Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland, USA.
authors.forename: Barry J
authors.identifier: http://orcid.org/0000-0002-8234-1540
authors.initials: BJ
authors.lastname: Richmond
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D003024:Clozapine / Q000031:analogs & derivatives; D015198:Designer Drugs; D005260:Female; D005821:Genetic Techniques; D005822:Genetic Vectors; D016086:Lentivirus; D008253:Macaca mulatta; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D051379:Mice; D020534:Parahippocampal Gyrus / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D012201:Reward; D013702:Temporal Lobe / Q000502:physiology*
chemical_list: D015198:Designer Drugs; D003024:Clozapine; C079149:clozapine N-oxide