title: [Intensive pharmacovigilance of clozapine in Argentina].
abstract: Approximately 12,000 individuals are treated with clozapine per year in Argentina. The use of this antipsychotic is associated with the occurrence of various side effects; the most serious of these is agranulocytosis, which can be fatal but reversible if detected early. For this reason, clozapine is under a pharmacovigilance intensive program centered by the National Administration of Drugs, Foods and Medical Devices. The present paper reviewed the current legislation for the use of clozapine in Argentina and compared the data obtained from the pharmacovigilance system with those reported in other countries. Further, difficulties that may arise during the reexposure of patients to clozapine are discussed.
authors.forename: María V
authors.initials: MV
authors.lastname: Balda
authors.affiliation: III Cátedra de Farmacología, Facultad de Medicina, UBA. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. fdaray@hotmail.com.
authors.forename: Federico M
authors.initials: FM
authors.lastname: Daray
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001118:Argentina; D003024:Clozapine / Q000009:adverse effects / Q000627:therapeutic use*; D016903:Drug Monitoring; D006801:Humans; D060735:Pharmacovigilance; D017410:Practice Guidelines as Topic
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine