title: Association between omentin-1, bone metabolism markers, and cytokines of the RANKL/RANK/OPG system in girls with anorexia nervosa.
abstract: BACKGROUND
  Omentin-1, secreted by visceral adipose tissue, has been indicated in the regulation of bone metabolism in girls with anorexia nervosa (AN). The aim of the study was to evaluate the relationship between omentin-1 and bone metabolism in girls with AN as well as the potential involvement of OPG and RANKL in this relationship.
  
  
  METHODS
  Serum omentin-1, OC, CTx, OPG, and sRANKL were determined by ELISA in 49 girls with AN and in 30 healthy controls, aged 13 to 17 years.
  
  
  RESULTS
  Girls with AN exhibited significant reduction in body weight, BMI, and Cole index as well as a significant increase in serum omentin-1 levels, compared to healthy participants. These changes were associated with a significant decrease in serum OC and CTx levels and a significant increase in OPG and sRANKL while the OC/CTx and OPG/sRANKL ratios were significantly decreased. BMI and the Cole index correlated negatively and significantly with omentin-1 levels, positively with CTx levels and the OC/CTx ratio in the control group (C), girls with AN, and all study participants (C + AN). Girls with AN showed a significant negative correlation between BMI, the Cole index, and OPG levels. The combined group (C + AN) showed a significant positive correlation between BMI, the Cole index, and the OPG/sRANKL ratio. Omentin-1 levels correlated negatively and significantly with OC and CTx levels as well as with the OC/CTx and OPG/sRANKL ratios in the C, AN, and C + AN groups.
  
  
  CONCLUSIONS
  The relationship between omentin-1, bone markers, and the OC/CTx and OPG/sRANKL ratios observed in girls with AN indicates the involvement of this adipokine in the regulation of dynamic balance between bone formation and resorption processes. Omentin-1 might exert a negative effect on bone remodelling in girls with AN by inhibiting both bone formation and resorption. The OPG/sRANKL system plays an important role in the latter.
authors.forename: Karolina
authors.initials: K
authors.lastname: Gołąbek
authors.affiliation: Department of Medical and Molecular Biology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland. ozdrasiek@poczta.onet.pl.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Ostrowska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Ziora
authors.forename: Joanna
authors.initials: J
authors.lastname: Oświęcimska
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Świętochowska
authors.forename: Bogdan
authors.initials: B
authors.lastname: Marek
authors.forename: Dariusz
authors.initials: D
authors.lastname: Kajdaniuk
authors.forename: Joanna
authors.initials: J
authors.lastname: Strzelczyk
authors.forename: Beata
authors.initials: B
authors.lastname: Kos-Kudła
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D016723:Bone Remodeling; D020756:Coatomer Protein / Q000097:blood*; D016207:Cytokines / Q000097:blood* / Q000502:physiology; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood / Q000502:physiology; D006801:Humans; D037102:Lectins / Q000097:blood* / Q000502:physiology; D015675:Osteocalcin / Q000097:blood*; D053245:RANK Ligand / Q000097:blood*
chemical_list: D020756:Coatomer Protein; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D053245:RANK Ligand; C505688:TNFSF11 protein, human; D015675:Osteocalcin
keywords: OPG; anorexia nervosa; bone metabolism; girls; omentin-1; sRANKL