title: Clozapine and risperidone influence on cortisol and estradiol levels in male patients with schizophrenia.
abstract: Estrogens role in schizophrenia patients is a subject, which has gained an increased attention from the medical community. Estrogens have been shown to inhibit dopamine actions, improve neuronal regeneration, and overall, have a protective role in the pathology of schizophrenia. The adjunctive estrogen therapy for men is currently under debate. Antipsychotic medication is known to influence the hypothalamo-hypophyseal - gonadal axis by inducing variable degrees of hyperprolactinemia. Several studies have found that some of the atypical antipsychotics lower cortisol levels in patients and also in healthy controls. We have investigated the effects of clozapine and risperidone on estradiol levels in men with schizophrenia. We have also evaluated the levels of prolactin and cortisol, taking into account the possible influence of antipsychotic drugs on both these hormones. Both prolactin and cortisol also have the potential to regulate sexual hormones biosynthesis. Our study found decreased estradiol levels in men with schizophrenia treated with clozapine and risperidone, while prolactin levels were increased only in the risperidone treated group. Cortisol levels are not statistically significant different between groups.
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Sapoca Neuropsychiatry Hospital, Buzau, Romania.
authors.forename: G
authors.initials: G
authors.lastname: Piriu
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; R & D Irist Labmed, Bucharest, Romania.
authors.forename: E
authors.initials: E
authors.lastname: Torac
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; R & D Irist Labmed, Bucharest, Romania.
authors.forename: L E
authors.initials: LE
authors.lastname: Gaman
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; R & D Irist Labmed, Bucharest, Romania.
authors.forename: L
authors.initials: L
authors.lastname: Iosif
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; R & D Irist Labmed, Bucharest, Romania.
authors.forename: I C
authors.initials: IC
authors.lastname: Tivig
authors.affiliation: "Prof. Dr. A. Rusescu" Institute for Mother and Child, Bucharest, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Delia
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; R & D Irist Labmed, Bucharest, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Gilca
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; R & D Irist Labmed, Bucharest, Romania.
authors.forename: I
authors.initials: I
authors.lastname: Stoian
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: V
authors.initials: V
authors.lastname: Atanasiu
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001569:Benzodiazepines; D016022:Case-Control Studies; D003024:Clozapine / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D006966:Hyperprolactinemia; D008297:Male; D008875:Middle Aged; D011388:Prolactin; D018967:Risperidone / Q000627:therapeutic use*; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D004958:Estradiol; D011388:Prolactin; D003024:Clozapine; D018967:Risperidone; D006854:Hydrocortisone
keywords: atypical antipsychotics; cortisol; estrogen; men