title: Chemoprevention trials of GI cancers in Asia.
abstract: Cancers are among the leading causes of morbidity and mortality worldwide, with gastrointestinal (GI) luminal cancers accounting for a large proportion of cancer incidence. Chemoprevention of GI luminal cancers is important to reduce this cancer burden. Screening for and eradication of Helicobacter pylori (H. pylori) in areas with high gastric cancer incidence is a safe and effective strategy to decrease the incidence of gastric cancer. Eradication of H. pylori also seems to be effective in preventing metachronous cancer development after endoscopic resection of early gastric cancer. For the average risk individual, COX inhibitors may have a role in reducing the incidence of adenoma formation as well as colorectal cancer, bearing in mind its inherent risks. There is currently insufficient evidence to recommend a chemoprevention agent against esophageal and small intestine cancer.
authors.affiliation: Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore. Electronic address: james.li@mohh.com.sg.
authors.forename: James Weiquan
authors.initials: JW
authors.lastname: Li
authors.affiliation: Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore. Electronic address: malcolm_tan@cgh.com.sg.
authors.forename: Malcolm Teck Kiang
authors.initials: MT
authors.lastname: Tan
authors.affiliation: Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore. Electronic address: tiing_leong_ang@cgh.com.sg.
authors.forename: Tiing Leong
authors.initials: TL
authors.lastname: Ang
authors.affiliation: Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore. Electronic address: eng_kiong_teo@cgh.com.sg.
authors.forename: Eng Kiong
authors.initials: EK
authors.lastname: Teo
mesh_terms: D001208:Asia; D018890:Chemoprevention; D015179:Colorectal Neoplasms / Q000517:prevention & control; D055088:Early Detection of Cancer; D004938:Esophageal Neoplasms / Q000517:prevention & control; D005770:Gastrointestinal Neoplasms / Q000382:microbiology / Q000517:prevention & control*; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D015994:Incidence; D013274:Stomach Neoplasms / Q000382:microbiology / Q000517:prevention & control / Q000601:surgery
keywords: Chemoprevention; Colon cancer; Colorectal cancer; Dysplasia; Esophageal cancer; Gastric cancer; Neoplasm; Precancerous; Prevention; Risk factor; Small bowel cancer