title: TREM2 rare variant p.R47H is not associated with Parkinson's disease.
abstract: Variant p.R47H of triggering receptor expressed on myeloid cells 2 (TREM2) has been associated with Parkinson's disease (PD). We screened this TREM2-variant in 821 PD patients including 261 demented PD patients (PDD) and in healthy controls (n = 919). Neither the entire PD nor the small PDD sample was associated with p.R47H.
authors.affiliation: Department of Neurology, Philipps-University of Marburg, 35043 Marburg, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Mengel
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Thelen
authors.affiliation: Department of Neurology, Philipps-University of Marburg, 35043 Marburg, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Balzer-Geldsetzer
authors.affiliation: Department of Neurology, Philipps-University of Marburg, 35043 Marburg, Germany.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Söling
authors.affiliation: Department of Neurology, RWTH Aachen, 52074 Aachen, Germany.
authors.forename: Jan-Philipp
authors.initials: JP
authors.lastname: Bach
authors.affiliation: Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tuebingen, and German Center for Neurodegenerative Diseases, 72076 Tuebingen, Germany.
authors.forename: Eva
authors.initials: E
authors.lastname: Schaeffer
authors.affiliation: German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Herold
authors.affiliation: German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany; Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, 53127 Bonn, Germany.
authors.forename: Tim
authors.initials: T
authors.lastname: Becker
authors.affiliation: Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tuebingen, and German Center for Neurodegenerative Diseases, 72076 Tuebingen, Germany.
authors.forename: Inga
authors.initials: I
authors.lastname: Liepelt
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany.
authors.forename: Julian
authors.initials: J
authors.lastname: Becker
authors.affiliation: Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, 04103 Leipzig, Germany.
authors.forename: Steffi
authors.initials: S
authors.lastname: Riedel-Heller
authors.affiliation: Department of Primary Medical Care, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Scherer
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany; Department of Psychiatry and Psychotherapy, University of Cologne, 50937 Cologne, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Jessen
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.affiliation: Department of Neurology, Philipps-University of Marburg, 35043 Marburg, Germany.
authors.forename: Richard
authors.initials: R
authors.lastname: Dodel
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany. Electronic address: alfredo.ramirez@ukb.uni-bonn.de.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ramirez
mesh_terms: D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011971:Receptors, Immunologic / Q000235:genetics*
chemical_list: D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C498715:TREM2 protein, human
keywords: Association; Dementia; Non-motor symptoms; Parkinson's disease; TREM2