title: Ultrasound Accelerated Thrombolysis May Be an Effective and Safe Treatment Modality for Intermediate Risk/Submassive Pulmonary Embolism.
abstract: Pulmonary embolism (PE) is a potentially life-threatening condition and the fact that 90% of PE originate from lower limb veins highlights the significance of early detection and treatment of deep vein thrombosis. Massive/high risk PE involving circulatory collapse or systemic arterial hypotension is associated with an early mortality rate of approximately 50%, in part from right ventricular (RV) failure. Intermediate risk/submassive PE, on the other hand, is defined as PE-related RV dysfunction, troponin and/or B-type natriuretic peptide elevation despite normal arterial pressure. Without prompt treatment, patients with intermediate risk PE may progress to the massive category with a potentially fatal outcome. In patients with PE and right ventricular dysfunction (RVD), in hospital mortality ranges from 5% to 17%, significantly higher than in patients without RVD.
authors.affiliation: Department of Cardiology, Cukurova University, Faculty of Medicine.
authors.forename: Caglar
authors.initials: C
authors.lastname: Ozmen
authors.forename: Ali
authors.initials: A
authors.lastname: Deniz
authors.forename: Rabia Eker
authors.initials: RE
authors.lastname: Akilli
authors.forename: Onur Sinan
authors.initials: OS
authors.lastname: Deveci
authors.forename: Caglar Emre
authors.initials: CE
authors.lastname: Cagliyan
authors.forename: Halil
authors.initials: H
authors.lastname: Aktas
authors.forename: Aziz İnan
authors.initials: Aİ
authors.lastname: Celik
authors.forename: Ayca Acikalin
authors.initials: AA
authors.lastname: Akpinar
authors.forename: Nezihat Rana
authors.initials: NR
authors.lastname: Disel
authors.forename: Hüseyin Tugsan
authors.initials: HT
authors.lastname: Balli
authors.forename: İsmail
authors.initials: İ
authors.lastname: Hanta
authors.forename: Mesut
authors.initials: M
authors.lastname: Demir
authors.forename: Ayhan
authors.initials: A
authors.lastname: Usal
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kanadasi
mesh_terms: D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D011655:Pulmonary Embolism / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D012189:Retrospective Studies; D012307:Risk Factors; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000379:methods*; D018497:Ventricular Dysfunction, Right / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D016278:Ventricular Function, Right
chemical_list: D010959:Tissue Plasminogen Activator