title: Can aging be 'drugged'?
abstract: The engines that drive the complex process of aging are being identified by model-organism research, thereby providing potential targets and rationale for drug studies. Several studies of small molecules have already been completed in animal models with the hope of finding an elixir for aging, with a few compounds showing early promise. What lessons can we learn from drugs currently being tested, and which pitfalls can we avoid in our search for a therapeutic for aging? Finally, we must also ask whether an elixir for aging would be applicable to everyone, or whether we age differently, thus potentially shortening lifespan in some individuals.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, California, USA.|Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.|Glenn Center for Research on Aging, University of California at Berkeley, Berkeley, California, USA.
authors.forename: Celine E
authors.initials: CE
authors.lastname: Riera
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, California, USA.|Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.|Glenn Center for Research on Aging, University of California at Berkeley, Berkeley, California, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Dillin
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D004364:Pharmaceutical Preparations