title: Comparative evaluation of the aphrodisiac efficacy of sildenafil and Carpolobia lutea root extract in male rabbits.
abstract: OBJECTIVE
  In spite of the folkloric use of the root of Carpolobia lutea as a sexual stimulant in man, there has been limited scientific proof of its efficacy. This study compares the efficacy of methanol extract of C. lutea root (MECLR) and sildenafil on the sexual activity of male rabbits.
  
  
  METHODS
  20 adult male rabbits were grouped into four of five rabbits each. Groups 1-4 were treated orally for 28 days with 2 ml/kg 1% Tween-20 (vehicle), 40 mg/kg MECLR, 80 mg/kg MECLR, and 0.5 mg/kg sildenafil citrate (SC), respectively. Sexual activities of males from each group were assessed by cohabiting them with sexually receptive female at estrus on days 0, 1, 3, and 5 using digital camera mounted on mating arena. Serum testosterone and nitric oxide concentration of the corpora cavernosa homogenates were also determined.
  
  
  RESULTS
  MECLR caused a dose-dependent significant increase in mount frequency, intromission frequency and ejaculatory latency (EL) while it reduced mount latency, intromission latency and post EL (similar to SC) when compared with the control. MECLR also caused significant increase in nitric oxide concentration in corpora cavernosa but no change in serum testosterone concentration.
  
  
  CONCLUSIONS
  Results suggest that MECLR enhances male sexual activity possibly by augmenting nitric oxide concentration. This study thus provides a novel scientific rationale for the use of C. lutea in the management of penile erectile dysfunction and impaired libido.
authors.affiliation: Department of Physiology, Laboratory for Reproductive Physiology and Developmental Programming, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: Ayobami
authors.initials: A
authors.lastname: Dare
authors.affiliation: Department of Physiology, College of Medicine, Lagos State University, Ikeja, Lagos, Nigeria.
authors.forename: Shakiru Ademola
authors.initials: SA
authors.lastname: Salami
authors.affiliation: Department of Physiology, Laboratory for Reproductive Physiology and Developmental Programming, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: Olufadekemi Tolulope
authors.initials: OT
authors.lastname: Kunle-Alabi
authors.affiliation: Department of Physiology, Laboratory for Reproductive Physiology and Developmental Programming, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: Opeyemi Oreofe
authors.initials: OO
authors.lastname: Akindele
authors.affiliation: Department of Physiology, Laboratory for Reproductive Physiology and Developmental Programming, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: Yinusa
authors.initials: Y
authors.lastname: Raji
keywords: Carpolobia lutea; aphrodisiac; efficacy; male; rabbits