title: Approaches in methodology for population-based longitudinal study on neuroprotective model for healthy longevity (TUA) among Malaysian Older Adults.
abstract: A number of longitudinal studies on aging have been designed to determine the predictors of healthy longevity, including the neuroprotective factors, however, relatively few studies included a wide range of factors and highlighted the challenges faced during data collection. Thus, the longitudinal study on neuroprotective model for healthy longevity (LRGS TUA) has been designed to prospectively investigate the magnitude of cognitive decline and its risk factors through a comprehensive multidimensional assessment comprising of biophysical health, auditory and visual function, nutrition and dietary pattern and psychosocial aspects. At baseline, subjects were interviewed for their status on sociodemographic, health, neuropsychological test, psychosocial and dietary intake. Subjects were also measured for anthropometric and physical function and fitness. Biospecimens including blood, buccal swap, hair and toenail were collected, processed and stored. A subsample was assessed for sensory function, i.e., vision and auditory. During follow-up, at 18 and 36 months, most of the measurements, along with morbidity and mortality outcomes will be collected. The description of mild cognitive impairment, successful aging and usual aging process is presented here. A total 2322 respondents were recruited in the data analysis at baseline. Most of the respondents were categorized as experiencing usual aging (73 %), followed by successful aging (11 %) and mild cognitive impairment (16 %). The LRGS TUA study is the most comprehensive longitudinal study on aging in Malaysia, and will contribute to the understanding of the aging process and factors associated with healthy aging and mental well-being of a multiethnic population in Malaysia.
authors.affiliation: Dietetic Programme, Centre of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia. suzana.shahar@gmail.com.
authors.forename: Suzana
authors.initials: S
authors.lastname: Shahar
authors.affiliation: Institute of Public Health Ministry of Health, Jalan Bangsar, Federal Hill, 59000, Kuala Lumpur, Malaysia.
authors.forename: Azahadi
authors.initials: A
authors.lastname: Omar
authors.affiliation: Dietetic Programme, Centre of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
authors.forename: Divya
authors.initials: D
authors.lastname: Vanoh
authors.affiliation: Malaysian Research Institute on Ageing, Universiti Putra Malaysia, 43300, Serdang, Selangor, Malaysia.
authors.forename: Tengku Aizan
authors.initials: TA
authors.lastname: Hamid
authors.affiliation: Audiology Programme, Centre of Rehabilitation Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
authors.forename: Siti Zamratol Mai-Sarah
authors.initials: SZ
authors.lastname: Mukari
authors.affiliation: Health Psychology Programme, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
authors.forename: Normah Che
authors.initials: NC
authors.lastname: Din
authors.affiliation: Biomedical Science Programme, Center of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
authors.forename: Nor Fadilah
authors.initials: NF
authors.lastname: Rajab
authors.affiliation: Optometry and Vision Sciences Programme, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
authors.forename: Zainora
authors.initials: Z
authors.lastname: Mohammed
authors.affiliation: Malaysian Research Institute on Ageing, Universiti Putra Malaysia, 43300, Serdang, Selangor, Malaysia.
authors.forename: Rahimah
authors.initials: R
authors.lastname: Ibrahim
authors.affiliation: Nutrition Programme, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Won Hui
authors.initials: WH
authors.lastname: Loo
authors.affiliation: Biomedical Science Programme, Center of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
authors.forename: Asheila
authors.initials: A
authors.lastname: Meramat
authors.affiliation: Dietetic Programme, Centre of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
authors.forename: Mohd Zul Amin
authors.initials: MZ
authors.lastname: Kamaruddin
authors.affiliation: Malaysian Research Institute on Ageing, Universiti Putra Malaysia, 43300, Serdang, Selangor, Malaysia.
authors.forename: Mohamad Fazdillah
authors.initials: MF
authors.lastname: Bagat
authors.affiliation: Department of Psychiatry, University Kebangsaan Medical Centre, Jalan Yaacob Latif, 56000, Cheras, Kuala Lumpur, Malaysia.
authors.forename: Rosdinom
authors.initials: R
authors.lastname: Razali
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control; D005260:Female; D015577:Geriatric Assessment / Q000379:methods; D006801:Humans; D008136:Longevity / Q000502:physiology*; D008137:Longitudinal Studies; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D000066829:Neuroprotection / Q000502:physiology*; D009483:Neuropsychological Tests; D015596:Nutrition Assessment; D065840:Protective Factors; D011597:Psychomotor Performance; D012307:Risk Factors
keywords: Longitudinal; Mild cognitive impairment; Morbidity; Mortality; Successful aging; Usual aging