title: The potential diagnostic power of extracellular vesicle analysis for multiple myeloma.
abstract: Multiple myeloma (MM) is a hematologic malignancy of plasma cells (PCs). In the United States, MM accounts for approximately 1% of all diagnoses and 2% of all cancer-related deaths. Although MM is a treatable disease, most patients eventually relapse, and despite the development of numerous treatment options it is still considered incurable. Mechanisms of communication between MM-PCs and bone marrow microenvironment, including cell-cell contacts and release of pro-survival factors, promote cancer cell survival and drug resistance. Recently, the importance of extracellular vesicles (EVs) as mechanisms of communication between MM cells and other cells in the microenvironment has been reported. In this review, the authors provide the update on the biology and clinical aspects of EVs in MM.
authors.affiliation: a Comprehensive Cancer Center , The Ohio State University , Columbus , OH , USA.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Canella
authors.affiliation: a Comprehensive Cancer Center , The Ohio State University , Columbus , OH , USA.|b Department of Molecular Virology, Immunology and Medical Genetics , The Ohio State University , Columbus , OH , USA.
authors.forename: Sean W
authors.initials: SW
authors.lastname: Harshman
authors.affiliation: a Comprehensive Cancer Center , The Ohio State University , Columbus , OH , USA.
authors.forename: Hanna S
authors.initials: HS
authors.lastname: Radomska
authors.affiliation: a Comprehensive Cancer Center , The Ohio State University , Columbus , OH , USA.|b Department of Molecular Virology, Immunology and Medical Genetics , The Ohio State University , Columbus , OH , USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Freitas
authors.affiliation: c Department of Internal Medicine, Division of Hematology , The Ohio State University , Columbus , OH , USA.
authors.forename: Flavia
authors.initials: F
authors.lastname: Pichiorri
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D000067128:Extracellular Vesicles / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D009101:Multiple Myeloma / Q000378:metabolism / Q000473:pathology*; D059016:Tumor Microenvironment
chemical_list: D014408:Biomarkers, Tumor
keywords: Multiple myeloma; exosomes; microRNA; microenvironment; microvesicles