title: Recurrence of liver metastases from colorectal cancer and repeat liver resection.
abstract: OBJECTIVE
  The purpose of this study was to assess the resectability and effectiveness of repeat hepatectomy for relapsing liver metastases of colorectal origin in terms of morbidity, mortality, overall survival, and disease-free survival.
  
  
  METHODS
  A retrospective study was performed on a prospective cohort of patients with colorectal liver metastases who underwent repeat surgery at Hospital Universitario San Cecilio, Granada (Spain), from March 2003 to June 2013. Primary outcome variables included survival and morbidity within 30 days post-surgery.
  
  
  RESULTS
  A total of 147 patients with colorectal liver metastases underwent surgical excision during the study period; 61 patients had liver recurrence, and 34 of these received repeat surgery. The overall survival rate at 5 and 10 years for resected patients (n=27/34) was 48% and 48%. Mean hospital stay was 8.9 ± 3.5 days, morbidity was 9%, and mortality was 0%.
  
  
  CONCLUSIONS
  Repeat liver resection for colorectal liver metastases is a safe, effective surgical procedure whose results are similar to those obtained after initial liver resection.
authors.affiliation: Cirugía y sus Especialidades, Universidad de Granada, ESPAÑA.
authors.forename: Francisco
authors.initials: F
authors.lastname: Navarro-Freire
authors.affiliation: Hospital de Santa Lucía. Cartagena, Murcia.
authors.forename: Patricia
authors.initials: P
authors.lastname: Navarro-Sánchez
authors.affiliation: Hospital Universitario San Cecilio. Granada.
authors.forename: Benito
authors.initials: B
authors.lastname: Mirón-Pozo
authors.affiliation: Hospital Universitario San Cecilio. Granada.
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Delgado-Ureña
authors.affiliation: Hospital Universitario San Cecilio. Granada.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Jiménez-Ríos
authors.affiliation: Universidad de Granada.
authors.forename: Pedro Antonio
authors.initials: PA
authors.lastname: García-López
authors.affiliation: Universidad de Granada.
authors.forename: Juan Ignacio
authors.initials: JI
authors.lastname: Arcelus-Martínez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D012086:Reoperation; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome