title: Electrochemical biosensors based on nanofibres for cardiac biomarker detection: A comprehensive review.
abstract: The vital importance of early and accurate diagnosis of cardiovascular diseases (CVDs) to prevent the irreversible damage or even death of patients has driven the development of biosensor devices for detection and quantification of cardiac biomarkers. Electrochemical biosensors offer rapid sensing, low cost, portability and ease of use. Over the past few years, nanotechnology has contributed to a tremendous improvement in the sensitivity of biosensors. In this review, the authors summarise the state-of-the-art of the application of one particular type of nanostructured material, i.e. nanofibres, for use in electrochemical biosensors for the ultrasensitive detection of cardiac biomarkers. A new way of classifying the nanofibre-based electrochemical biosensors according to the electrical conductance and the type of nanofibres is presented. Some key data from each article reviewed are highlighted, including the mechanism of detection, experimental conditions and the response range of the biosensor. The primary aim of this review is to emphasise the prospects for nanofibres for the future development of biosensors in diagnosis of CVDs as well as considering how to improve their characteristics for application in medicine.
authors.affiliation: Nanotechnology Institute, Amirkabir University of Technology, Tehran 15875-4413, Iran; Department of Textile Engineering, AmirKabir University of Technology, Tehran 15875-4413, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Rezaei
authors.affiliation: Nanotechnology Institute, Amirkabir University of Technology, Tehran 15875-4413, Iran; Department of Textile Engineering, AmirKabir University of Technology, Tehran 15875-4413, Iran.
authors.forename: Mozhdeh
authors.initials: M
authors.lastname: Ghani
authors.affiliation: Nanotechnology Institute, Amirkabir University of Technology, Tehran 15875-4413, Iran; Department of Textile Engineering, AmirKabir University of Technology, Tehran 15875-4413, Iran. Electronic address: amousavi@aut.ac.ir.
authors.forename: Ahmad Mousavi
authors.initials: AM
authors.lastname: Shoushtari
authors.affiliation: Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rabiee
mesh_terms: D015415:Biomarkers; D015374:Biosensing Techniques / Q000379:methods*; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000235:genetics; D055664:Electrochemical Techniques; D006801:Humans; D057139:Nanofibers / Q000737:chemistry* / Q000627:therapeutic use; D036103:Nanotechnology
chemical_list: D015415:Biomarkers
keywords: Biomarkers; Cardiovascular diseases; Diagnostics; Electrochemical immunosensor; Nanofibres family