title: Non-coding RNAs as orchestrators of autophagic processes.
abstract: Autophagy is an important quality control mechanism present in all cells to maintain their cellular homeostasis. An imbalance in the autophagic process had been reported in numerous diseases including cardiovascular disease and is associated with serious consequences. Thus, knowledge of key regulators of cardiac autophagy is helpful to regain a balanced autophagic activity and to maintain healthy myocardial function. In this review we summarize all microRNAs which had been reported to regulate cardiac autophagy to date. In addition, we discuss long noncoding RNAs and circular RNAs as potential modulators of autophagy. Altering non-coding RNAs in-vivo by novel therapeutics offers a promising approach to treat autophagy-related diseases.
authors.affiliation: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Germany. Electronic address: Gupta.Shashi@mh-hannover.de.
authors.forename: Shashi Kumar
authors.initials: SK
authors.lastname: Gupta
authors.affiliation: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Germany; Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany; National Heart and Lung Institute, Imperial College London, United Kingdom. Electronic address: Thum.Thomas@mh-hannover.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Thum
mesh_terms: D000818:Animals; D000071182:Autophagosomes / Q000378:metabolism; D001343:Autophagy / Q000235:genetics*; D001692:Biological Transport; D006332:Cardiomegaly / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism
chemical_list: D062085:RNA, Long Noncoding
keywords: Apoptosis; Atg; Autophagy; Hypertrophy; MicroRNA; mTOR