title: Successful antibiotic treatment for subdural empyema and seizure due to methicillin-resistant Staphylococcus aureus as a complication of halo orthosis usage: a case report.
abstract: Halo orthosis is used for cervical spine fixation after spinal surgery or injury. Although superficial infection at pin sites occurs frequently, intracranial development of infection, including brain abscesses, is very rare. We experienced subdural empyema due to methicillin-resistant Staphylococcus aureus (MRSA) caused by intracranial penetration of halo pins. A 38-year-old woman with a 4-year history of rheumatoid arthritis experienced severe myelopathy due to atlanto-axial dislocation and vertical subluxation. Reduction and immobilization using a halo vest resulted in neurologic improvement; she later underwent occipital bone to C2 fusion using posterior instrumentation. Three months after halo orthosis fixation, she complained of a headache, experienced a generalized tonic-clonic seizure, and became unconscious for 10 min. Computed tomography revealed pneumoencephalus, and Gd-enhanced magnetic resonance imaging revealed edema, enhancement of the overlying dura in the left partial lobe, and subdural and subarachnoidal empyema. Following removal of the halo vest, there was a purulent discharge from the left-posterior pin site. Culture of the discharge was positive for MRSA. The patient was treated with intravenous vancomycin for 2 weeks, followed by cefozopran hydrochloride for 4 weeks. Her symptoms improved, and additional surgery was not required. At latest follow-up, 10 years after the seizure, she is neurologically stable without any recurrence of the infection.
authors.affiliation: Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Hioki
authors.affiliation: Department of Reconstructive Surgery for Spine, Bone, and Joint, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan. kei@bg8.so-net.ne.jp.
authors.forename: Kei
authors.initials: K
authors.lastname: Miyamoto
authors.affiliation: Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Inoue
authors.affiliation: Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Hosoe
authors.affiliation: Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Shinoda
authors.affiliation: Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Iwama
authors.affiliation: Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Katsuji
authors.initials: K
authors.lastname: Shimizu
keywords: Antibiotic chemotherapy; Complication; Halo orthosis; Methicillin-resistant Staphylococcus aureus (MRSA); Subdural empyema