title: Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex.
abstract: The callosal connections between the two hemispheres of the neocortex are altered in certain psychiatric disorders including schizophrenia. However, how and why the callosal connection is impaired in patients suffering from psychiatric diseases remain unclear. Filamin A interacting protein (FILIP), whose alteration through mutation relates to schizophrenic pathogenesis, binds to actin-binding proteins and controls neurotransmission. Because cortical excitatory neurons, including callosal projection neurons, migrate to the cortical plate during development, with the actin-binding proteins playing crucial roles during migration, we evaluated whether FILIP is involved in the development of the callosal projection neurons by histological analysis of Filip-knockout mice. The positioning of the callosal projection neurons, especially those expressing Plxnd1, in the superficial layer of the cortex is disturbed in these mice, which suggests that FILIP is a key molecule that links callosal projections to the pathogenesis of brain disorders.
authors.affiliation: Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan; Department of Anatomy and Cell Biology, Hyogo College of Medicine, Hyogo 663-8501, Japan.
authors.forename: Hideshi
authors.initials: H
authors.lastname: Yagi
authors.affiliation: Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka 565-0871, Japan; Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Oka
authors.affiliation: Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
authors.forename: Munekazu
authors.initials: M
authors.lastname: Komada
authors.affiliation: Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan; Research Center for Child Mental Development, University of Fukui, Fukui 910-1193, Japan.
authors.forename: Min-Jue
authors.initials: MJ
authors.lastname: Xie
authors.affiliation: Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663-8501, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Noguchi
authors.affiliation: Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka 565-0871, Japan; Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan; Research Center for Child Mental Development, University of Fukui, Fukui 910-1193, Japan. Electronic address: makosato@anat2.med.osaka-u.ac.jp.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sato
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002540:Cerebral Cortex / Q000166:cytology*; D003337:Corpus Callosum / Q000166:cytology*; D018345:Mice, Knockout; D009474:Neurons / Q000502:physiology*
chemical_list: D002352:Carrier Proteins; C500538:FILIP protein, mouse
keywords: Callosal projection neuron; Cortical layer formation; FILIP; Knockout mouse; Neuronal migration; Schizophrenia