title: Increased red cell distribution width predicts occlusion of the infarct-related artery in STEMI.
abstract: OBJECTIVE
  Infarct-related artery (IRA) patency yields a better outcome in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Red cell distribution width (RDW) emerges as a marker of adverse cardiovascular events and mortality in STEMI. Therefore, we aimed to assess the relationship between IRA patency and RDW value on admission in patients with STEMI undergoing primary PCI.
  
  
  METHODS
  A total of 564 patients with STEMI undergoing primary PCI were recruited in this study. According to thrombolysis in myocardial infarction (TIMI) flow grade in the IRA before PCI, the study population was divided into two groups as TIMI 0 or 1 group (occluded IRA, n = 398) and TIMI 2 or 3 group (patent IRA, n = 166).
  
  
  RESULTS
  RDW was significantly higher in the occluded IRA group (15.1 ± 1.7 versus 13.4 ± 1.3, p < 0.001) as compared to the patent IRA group. White blood cell (WBC) count, platelet count, creatine kinase-myocardial band (CK-MB) and troponin-I levels were also significantly higher in the occluded IRA group (p < 0.05). Moreover, RDW showed positive correlations with troponin-I (r = 0.397, p < 0.001), CK-MB (r = 0.344, p < 0.001) and WBC (r = 0.219, p < 0.001). In multivariate regression analysis, RDW (OR: 0.483, 95% CI: 0.412-0.567, p < 0.001) and WBC count were significantly and independently associated with IRA patency.
  
  
  CONCLUSIONS
  Our findings suggested that RDW value and WBC count on admission were independent predictors of IRA patency in patients with STEMI. As RDW is an easily available, simple and cheap biomarker, it can be used in daily practice as a novel predictor for IRA patency.
authors.affiliation: a Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.
authors.forename: Mehmet Kadri
authors.initials: MK
authors.lastname: Akboga
authors.affiliation: a Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.
authors.forename: Cagri
authors.initials: C
authors.lastname: Yayla
authors.affiliation: a Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.
authors.forename: Samet
authors.initials: S
authors.lastname: Yilmaz
authors.affiliation: a Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Sen
authors.affiliation: a Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.
authors.forename: Kevser Gulcihan
authors.initials: KG
authors.lastname: Balci
authors.affiliation: a Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.
authors.forename: Firat
authors.initials: F
authors.lastname: Ozcan
authors.affiliation: a Turkiye Yuksek Ihtisas Training and Research Hospital, Cardiology Clinic , Ankara , Turkey.
authors.forename: Dursun
authors.initials: D
authors.lastname: Aras
mesh_terms: D000368:Aged; D016009:Chi-Square Distribution; D003326:Coronary Circulation; D054059:Coronary Occlusion / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D003430:Cross-Sectional Studies; D004909:Erythrocyte Indices; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D016017:Odds Ratio; D010343:Patient Admission; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014654:Vascular Patency
keywords: Infarct-related artery patency; STEMI; myocardial infarction; red cell distribution width