title: Heart Retransplant Recipients Have Better Survival With Concurrent Kidney Transplant Than With Heart Retransplant Alone.
abstract: BACKGROUND
  Heart retransplant (HRT) recipients represent a growing number of transplant patients. The impact of concurrent kidney transplants (KTs) in this population has not been well studied. We tested the hypothesis that recipients of HRT with concurrent KT (HRT-KT) would have worse survival than recipients of HRT alone.
  
  
  RESULTS
  A retrospective analysis of the United Network of Organ Sharing database was performed for all patients undergoing HRT from 1987 to 2011. There were 1660 HRT patients, of which 116 (7%) received concurrent KT. Those who received HRT-KT had older age, longer wait-list time, worse kidney function, and more known diabetes. Survival among recipients of HRT-KT was significantly better than that of recipients of HRT alone (P=0.005). A subgroup of 323 HRT patients with severe kidney dysfunction (estimated glomerular filtration rate <30 mL/min per 1.73 m(2) or on dialysis) was studied in more detail, and 76 (24%) received concurrent KT. Those on dialysis at the time of HRT had better survival with versus without concurrent KT (P<0.0001). On multivariable analysis, concurrent KT was independently associated with better outcomes for all patients with HRT and for the subgroup of patients with severe kidney dysfunction.
  
  
  CONCLUSIONS
  Recipients of HRT-KT have better survival than recipients of HRT alone. Further research is needed to determine which HRT patients may benefit the most from concurrent KT.
authors.affiliation: Department of Pediatrics, The Cardiac Center, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.S., K.Y.L., M.P., R.L.R., R.S.R., S.S.H., A.T.O., P.A., W.G., R.E.S., J.W.R.).
authors.forename: Jill
authors.initials: J
authors.lastname: Savla
authors.affiliation: Department of Pediatrics, The Cardiac Center, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.S., K.Y.L., M.P., R.L.R., R.S.R., S.S.H., A.T.O., P.A., W.G., R.E.S., J.W.R.).
authors.forename: Kimberly Y
authors.initials: KY
authors.lastname: Lin
authors.affiliation: Department of Pediatrics, The Cardiac Center, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.S., K.Y.L., M.P., R.L.R., R.S.R., S.S.H., A.T.O., P.A., W.G., R.E.S., J.W.R.).
authors.forename: Madhura
authors.initials: M
authors.lastname: Pradhan
authors.affiliation: Department of Pediatrics, The Cardiac Center, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.S., K.Y.L., M.P., R.L.R., R.S.R., S.S.H., A.T.O., P.A., W.G., R.E.S., J.W.R.).
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Ruebner
authors.affiliation: Department of Pediatrics, The Cardiac Center, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.S., K.Y.L., M.P., R.L.R., R.S.R., S.S.H., A.T.O., P.A., W.G., R.E.S., J.W.R.).
authors.forename: Rachel S
authors.initials: RS
authors.lastname: Rogers
authors.affiliation: Department of Pediatrics, The Cardiac Center, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.S., K.Y.L., M.P., R.L.R., R.S.R., S.S.H., A.T.O., P.A., W.G., R.E.S., J.W.R.).
authors.forename: Somaly S
authors.initials: SS
authors.lastname: Haskins
authors.affiliation: Department of Pediatrics, The Cardiac Center, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.S., K.Y.L., M.P., R.L.R., R.S.R., S.S.H., A.T.O., P.A., W.G., R.E.S., J.W.R.).
authors.forename: Anjali T
authors.initials: AT
authors.lastname: Owens
authors.affiliation: Department of Pediatrics, The Cardiac Center, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.S., K.Y.L., M.P., R.L.R., R.S.R., S.S.H., A.T.O., P.A., W.G., R.E.S., J.W.R.).
authors.forename: Peter
authors.initials: P
authors.lastname: Abt
authors.affiliation: Department of Pediatrics, The Cardiac Center, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.S., K.Y.L., M.P., R.L.R., R.S.R., S.S.H., A.T.O., P.A., W.G., R.E.S., J.W.R.).
authors.forename: J William
authors.initials: JW
authors.lastname: Gaynor
authors.affiliation: Department of Pediatrics, The Cardiac Center, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.S., K.Y.L., M.P., R.L.R., R.S.R., S.S.H., A.T.O., P.A., W.G., R.E.S., J.W.R.).
authors.forename: Robert E
authors.initials: RE
authors.lastname: Shaddy
authors.affiliation: Department of Pediatrics, The Cardiac Center, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (J.S., K.Y.L., M.P., R.L.R., R.S.R., S.S.H., A.T.O., P.A., W.G., R.E.S., J.W.R.).
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Rossano
mesh_terms: D000328:Adult; D000367:Age Factors; D005260:Female; D005919:Glomerular Filtration Rate; D016027:Heart Transplantation / Q000401:mortality*; D006801:Humans; D053208:Kaplan-Meier Estimate; D007674:Kidney Diseases / Q000601:surgery; D016030:Kidney Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D014850:Waiting Lists; D055815:Young Adult
keywords: heart; kidney; survival; transplantation