title: Chemical constituents from the roots and stems of Litsea cubeba.
abstract: A new monoterpene and a new lignan, named litsecols A and B (1 and 2), respectively, together with nine known compounds (3-11), were isolated in a continuous investigation on the roots and stems of Litsea cubeba. Their structures were elucidated on the basis of extensive spectroscopic data analysis, and the absolute configuration of 1 was resolved by X-ray diffraction analysis. Compounds 2-5 and 7-9 showed significant inhibitory activity against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine microglial (Bv-2) cell line. Compounds 10 and 11 exhibited significant neuroprotective effect against hydrogen peroxide-induced oxidative damage in rat adrenal pheochromocytoma (PC12) cell line.
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , 100029 , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , 100102 , China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Guo
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , 100029 , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , 100102 , China.
authors.forename: Rui-Feng
authors.initials: RF
authors.lastname: Bai
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , 100029 , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , 100102 , China.
authors.forename: Guo-Zhu
authors.initials: GZ
authors.lastname: Su
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , 100029 , China.
authors.forename: Zhi-Xiang
authors.initials: ZX
authors.lastname: Zhu
authors.affiliation: c State Key Laboratory of Natural and Biomimetic Drugs , Peking University Health Science Center , Beijing , 100191 , China.
authors.forename: Ke-Wu
authors.initials: KW
authors.lastname: Zeng
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , 100029 , China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Tu
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , 100029 , China.
authors.forename: Xing-Yun
authors.initials: XY
authors.lastname: Chai
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D032862:Litsea / Q000737:chemistry; D051379:Mice; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D051381:Rats
chemical_list: D004365:Drugs, Chinese Herbal; D017705:Lignans; D008070:Lipopolysaccharides; D039821:Monoterpenes; D018696:Neuroprotective Agents; C000608878:litsecol A; C000608879:litsecol B; D009569:Nitric Oxide; D006861:Hydrogen Peroxide
keywords: Lauraceae; Litsea cubeba; anti-inflammatory activity; neuroprotective effect