title: Expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin in localized prostate cancer.
abstract: OBJECTIVE
  To explore the correlation between the expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin in prostate cancer (PCa) and its clinicopathological data including tumor grade and clinical stage.
  
  
  METHODS
  The expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin was examined in 157 cases of PCa and adjacent normal prostatic tissue by immunohistochemical assay, and the correlation with clinicopathological features was analyzed.
  
  
  RESULTS
  Expressions of α5-integrin, α7-integrin, and Ε-cadherin in PCa were lower than those in normal prostatic tissues (P<0.05). N-cadherin expression was higher in cancer prostatic tissue than in normal prostatic tissues (P<0.05). The reduced expression of α5-integrin, α7-integrin, and Ε-cadherin was related to Gleason score, pathological stage, lymph node metastasis, and prostate-specific antigen level, but it was not associated with positive surgical margins and patient age. The increased expression of N-cadherin was related to Gleason score, pathological stage, lymph node metastasis, and prostate-specific antigen level, but not to age and positive surgical margins. The expression of E-cadherin was highly negatively correlated with that of N-cadherin and also positively correlated with that of α5-integrin and α7-integrin.
  
  
  CONCLUSIONS
  The reduced expression of α5-integrin, α7-integrin, and Ε-cadherin and abnormal expression of N-cadherin play an important role in the occurrence and development of PCa. The results indicate that these have potential values in the diagnosis and are predictable indices in the proliferation of PCa.
authors.affiliation: Department of Urology, Athens General Hospital "Elpis," Athens, Greece. Electronic address: alexdriv@yahoo.gr.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Drivalos
authors.affiliation: 2nd Department of Urology, School of Medicine, Sismanoglio Hospital, University of Athens, Athens, Greece.
authors.forename: Michael
authors.initials: M
authors.lastname: Chrisofos
authors.affiliation: Department of Clinical Therapeutics, School of Medicine, Alexandra Hospital, University of Athens, Athens, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Efstathiou
authors.affiliation: Department of Anatomopathology, Athens Navy Hospital, Athens, Greece.
authors.forename: Amalia
authors.initials: A
authors.lastname: Kapranou
authors.affiliation: Department of Urology, Athens General Hospital "Elpis," Athens, Greece.
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Kollaitis
authors.affiliation: Department of Anatomopathology, Athens Navy Hospital, Athens, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Koutlis
authors.affiliation: Department of Urology, Athens General Hospital "Elpis," Athens, Greece.
authors.forename: Nick
authors.initials: N
authors.lastname: Antoniou
authors.affiliation: Department of Urology, Athens General Hospital "Elpis," Athens, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Karanastasis
authors.affiliation: Department of Clinical Therapeutics, School of Medicine, Alexandra Hospital, University of Athens, Athens, Greece.
authors.forename: Meletios A
authors.initials: MA
authors.lastname: Dimopoulos
authors.affiliation: Department of Clinical Therapeutics, School of Medicine, Alexandra Hospital, University of Athens, Athens, Greece.
authors.forename: Aristotelis
authors.initials: A
authors.lastname: Bamias
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D015820:Cadherins / Q000096:biosynthesis*; D006801:Humans; D039001:Integrin alpha Chains / Q000096:biosynthesis*; D039482:Integrin alpha5 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C513384:CDH1 protein, human; C050361:CDH2 protein, human; D015820:Cadherins; D039001:Integrin alpha Chains; D039482:Integrin alpha5; C085725:integrin alpha7
keywords: Cadherins; Cell adhesion molecules; Integrins; Prostate cancer