title: Correlation of IL-27 genetic polymorphisms with the risk and survival of cervical cancer in a Chinese Han population.
abstract: Interleukin-27 (IL-27) has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties. However, there are no data about the role of IL-27 polymorphism in the development of cervical cancer. A hospital-based case-control study was conducted in 380 patients with cervical cancer and 380 healthy controls to investigate the possible associations of IL-27 gene polymorphisms (-964A/G, 2905T/G, and 4730T/C), with susceptibility to cervical cancer and clinical outcome. Our results suggested that the IL-27 2905T/G was significantly associated with a decreased risk of cervical cancer (TG vs. TT, odds ratio (OR) = 0.77; 95 % confidence interval (CI) = 0.60-0.86; GG vs. TT, OR = 0.95; 95 % CI = 0.72-0.96; TG+GG vs. TT, OR = 0.87; 95 % CI = 0.65-0.94). However, the genotype and allele frequencies of IL-27 (-964A/G and 4730T/C) polymorphisms in cervical cancer patients were not significantly different from controls. Further analysis showed IL-27 2905T/G genotypes were associated with advanced tumor stages of cervical cancer patients. More interestingly, the IL-27 2905T/G genotypes were statistically significantly associated with the survival in cervical cancer patients. Our results showed that the IL-27 2905T/G genotypes were associated with decreased susceptibility and development of cervical cancer in Chinese Han population.
authors.affiliation: Department of Medical Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China. woenck9834@sina.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Shi
authors.affiliation: College of Science and Technology, Yichang, 443002, Hubei, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Yuan
authors.affiliation: Department of Pathology, Bethune International Peace Hospital, Shijiazhuang, 050000, Hebei, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Medical Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China.
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Duan
authors.affiliation: Xingtai National Hospital, Xingtai, 054000, Hebei, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology
chemical_list: D007378:Interleukins; C464565:MYDGF protein, human
keywords: Cervical cancer; IL-27; Single nucleotide polymorphism; Susceptibility