title: Fatal case of acute gastroenteritis with multiple viral coinfections.
abstract: We report a fatal case of acute gastroenteritis in a child with autism spectrum disorder. Multiple viral coinfections were detected by PCR in the patient's stool and digestive biopsy specimens. As viral detection is not necessarily associated with symptomatic disease, a semi-quantitative approach using cycle treshold values was proposed for the clinical interpretation of PCR. We discuss whether concomitant viral infections could be a risk factor for severe outcome in gastroenteritis cases. Individual risk factors are also addressed.
authors.affiliation: Laboratory of Virology, University Hospital of Grenoble, Grenoble, France; CNRS, Unit for Virus Host-Cell Interactions, 38042 Grenoble, France; Université Grenoble Alpes, Unit for Virus Host-Cell Interactions, 38042 Grenoble, France. Electronic address: jlupo@chu-grenoble.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Lupo
authors.affiliation: Laboratory of Virology, University Hospital of Grenoble, Grenoble, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Morel-Baccard
authors.affiliation: Department of Pediatrics, University Hospital of Grenoble, Grenoble, France.
authors.forename: Anne-Pascale
authors.initials: AP
authors.lastname: Michard-Lenoir
authors.affiliation: Laboratory of Virology, University Hospital of Grenoble, Grenoble, France; CNRS, Unit for Virus Host-Cell Interactions, 38042 Grenoble, France; Université Grenoble Alpes, Unit for Virus Host-Cell Interactions, 38042 Grenoble, France.
authors.forename: Raphaële
authors.initials: R
authors.lastname: Germi
authors.affiliation: National Reference Center for Enteric Viruses, Laboratory of Virology, University Hospital of Dijon, Dijon, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Pothier
authors.affiliation: National Reference Center for Enteric Viruses, Laboratory of Virology, University Hospital of Dijon, Dijon, France.
authors.forename: Katia
authors.initials: K
authors.lastname: Ambert-Balay
authors.affiliation: Laboratory of Virology, University Hospital of Grenoble, Grenoble, France; CNRS, Unit for Virus Host-Cell Interactions, 38042 Grenoble, France; Université Grenoble Alpes, Unit for Virus Host-Cell Interactions, 38042 Grenoble, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Morand
mesh_terms: D002675:Child, Preschool; D060085:Coinfection / Q000175:diagnosis* / Q000821:virology*; D017809:Fatal Outcome; D005260:Female; D005759:Gastroenteritis / Q000175:diagnosis* / Q000821:virology*; D006801:Humans; D014777:Virus Diseases / Q000175:diagnosis* / Q000821:virology*; D014780:Viruses / Q000145:classification / Q000302:isolation & purification*
keywords: Acute gastroenteritis; Autism spectrum disorder; Coinfection; Cycle threshold value; Enteric viruses; Viral load