title: Immunoexpression of vascular endothelial growth factor in gingival mucosa with papilloma and condyloma acuminata.
abstract: The histological changes of the oral mucosa in contact with a metal alloy dentures is one of the current issues widely debated in the literature.
  
  
  OBJECTIVE
  To highlight the expression of vascular endothelial growth factor (VEGF) in human paraprosthetic gingival mucosa exposed to nickel and copper compounds using the immunohistochemical technique. The selected participants were wearers of fixed dentures made of nickel-based alloys and copper-based alloys. The gingival mucosa fragments were prelevated through excision after removing fixed denture and extraction one of its affected teeth. The gingival mucosa fragments were processed through the histological technique of paraffin inclusion. The paraffin-embedded tissue sections were usually stained with Hematoxylin-Eosin and processed by immunohistochemical technique with VEGF antibody. The gingival mucosa fragments from nickel-based alloys dentures wearers were diagnosed with papilloma and, also, gingival mucosa samples prelevated from copper-based alloys dentures wearers were diagnosed with condyloma acuminata. Immunohistochemical reaction for VEGF was different in the gingival mucosa fragments with papilloma compared with condyloma acuminata samples. In papillomatosis gingival mucosa fragments, VEGF was implicated in principal in vasodilatation and inflammation process, and secondary in angiogenesis. In gingival mucosa fragments with condyloma acuminata, the principal role of VEGF was in angiogenesis and secondary in inflammation.
authors.affiliation: Department of Prosthetic Dentistry, University of Medicine and Pharmacy of Craiova, Romania; scrieciu_monica@yahoo.com.
authors.forename: Monica
authors.initials: M
authors.lastname: Scrieciu
authors.forename: Veronica
authors.initials: V
authors.lastname: MercuŢ
authors.forename: Oana Cella
authors.initials: OC
authors.lastname: Andrei
authors.forename: Anca Mihaela
authors.initials: AM
authors.lastname: Predescu
authors.forename: Mihaela
authors.initials: M
authors.lastname: Niculescu
authors.forename: Cătălina Gabriela
authors.initials: CG
authors.lastname: Pisoschi
authors.forename: Ileana Monica
authors.initials: IM
authors.lastname: BaniŢă
mesh_terms: D003218:Condylomata Acuminata / Q000378:metabolism* / Q000473:pathology; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D005881:Gingiva / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D008938:Mitosis; D009061:Mouth Mucosa / Q000378:metabolism* / Q000473:pathology*; D010212:Papilloma / Q000378:metabolism* / Q000473:pathology; D020286:Pericytes / Q000378:metabolism / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D042461:Vascular Endothelial Growth Factor A