title: Treatment of Refractory Filamentary Keratitis With Autologous Serum Tears.
abstract: OBJECTIVE
  To report a case of filamentary keratitis (FK) successfully treated with autologous serum tears and to review the pathogenesis and management of FK.
  
  
  METHODS
  Case report including high-resolution anterior segment optical coherence tomography and filament histopathology.
  
  
  METHODS
  A 61-year-old Hispanic man presented with pain and photophobia of the right eye. He was found to have a corneal epithelial defect and a small peripheral infiltrate 4 months after Laser Assisted in situ Keratomileusis. After resolution of the epithelial defect, he developed FK. Over a 4-month period, conservative management with aggressive lubrication, lid hygiene, topical corticosteroids, topical cyclosporine, bandage contact lenses, and oral doxycycline failed to resolve the corneal filaments. Notably, treatment with 20% autologous serum tears, four times daily, led to a sustained resolution of the FK within 1 week.
  
  
  CONCLUSIONS
  This case demonstrates the complexity of FK management and introduces autologous serum tears as a viable management option when conservative approaches to this condition fail.
authors.affiliation: Department of Ophthalmology (S.P.R., M.R., S.D., C.L.K., A.G.), Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; and Department of Ophthalmology (A.G.), Miami Veterans Affairs Medical Center, Miami, FL.
authors.forename: Sarah P
authors.initials: SP
authors.lastname: Read
authors.forename: Marianeli
authors.initials: M
authors.lastname: Rodriguez
authors.forename: Sander
authors.initials: S
authors.lastname: Dubovy
authors.forename: Carol L
authors.initials: CL
authors.lastname: Karp
authors.forename: Anat
authors.initials: A
authors.lastname: Galor
mesh_terms: D003315:Cornea / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D007634:Keratitis / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism; D044967:Serum; D013666:Tears; D041623:Tomography, Optical Coherence
chemical_list: D009077:Mucins