title: Impact of predictors upon the reduction of lipid parameters in family medicine practice.
abstract: OBJECTIVE
  To evaluate predictors of changes in lipid parameters consisting of LDL-C (low-density lipoprotein cholesterol), TC (total cholesterol) and non-HDL-C (non-high density lipoprotein cholesterol) among primary care patients.
  
  
  METHODS
  Retrospective study conducted on family medicine patients.
  
  
  METHODS
  Demographic features and other clinically relevant information were abstracted from medical records. The primary outcome was the difference in LDL-C level from initial testing to the index test. Secondary outcomes were the changes in TC and non-HDL-C levels between two measurements.
  
  
  RESULTS
  Three hundred and eleven participants were included in the final secondary analysis. Multiple linear regression revealed that male patients (β = 4.97, P = 0.040), diabetes (β = 9.75, P = 0.003) and higher LDL-C levels at baseline (β = 0.35, P < 0.001) were positively associated with LDL variance, whereas longer time period (β = -0.15, P = 0.045) and familial hypercholesterolemia history (β = -7.56, P = 0.033) were negatively associated. Male patients (β = 8.45, P = 0.002), DM (β = 9.26, P = 0.011), higher TC levels at baseline (β = 0.35, P < 0.001) and taking statins (β = 7.31, P = 0.023) were positively associated with TC variance, whilst longer time period (β = -0.183, P = 0.031) and familial hypercholesterolemia (β = -10.70, P = 0.008) were negatively associated.
  
  
  CONCLUSIONS
  In the present study, patients who were male, on statin treatment, diagnosed with diabetes and had higher baseline lipid values were more likely associated with better lipid outcomes at future testing.
authors.affiliation: Department of Family Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Yusuf Cetin
authors.initials: YC
authors.lastname: Doganer
authors.affiliation: Department of Family Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Kurt
authors.initials: K
authors.lastname: Angstman
authors.affiliation: Department of Family Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: James
authors.initials: J
authors.lastname: Rohrer
authors.affiliation: Department of Family Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Merry
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000517:prevention & control; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood / Q000517:prevention & control; D004812:Epidemiologic Methods; D005194:Family Practice; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000097:blood / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors; D013997:Time Factors; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002784:Cholesterol