title: Regulation of Vascular and Renal Function by Metabolite Receptors.
abstract: To maintain metabolic homeostasis, the body must be able to monitor the concentration of a large number of substances, including metabolites, in real time and to use that information to regulate the activities of different metabolic pathways. Such regulation is achieved by the presence of sensors, termed metabolite receptors, in various tissues and cells of the body, which in turn convey the information to appropriate regulatory or positive or negative feedback systems. In this review, we cover the unique roles of metabolite receptors in renal and vascular function. These receptors play a wide variety of important roles in maintaining various aspects of homeostasis-from salt and water balance to metabolism-by sensing metabolites from a wide variety of sources. We discuss the role of metabolite sensors in sensing metabolites generated locally, metabolites generated at distant tissues or organs, or even metabolites generated by resident microbes. Metabolite receptors are also involved in various pathophysiological conditions and are being recognized as potential targets for new drugs. By highlighting three receptor families-(a) citric acid cycle intermediate receptors, (b) purinergic receptors, and
authors.affiliation: Department of Physiology and Biophysics and Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California 90033; email: petipete@usc.edu.
authors.forename: János
authors.initials: J
authors.lastname: Peti-Peterdi
authors.affiliation: Department of Internal Medicine and Center on Aging, University of Utah Health Sciences Center, Department of Veterans Affairs Salt Lake City Health Care System, Salt Lake City, Utah 84148; email: BK.Kishore@hsc.utah.edu.
authors.forename: Bellamkonda K
authors.initials: BK
authors.lastname: Kishore
authors.affiliation: Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; email: jpluznick@jhmi.edu.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Pluznick
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000378:metabolism* / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface
keywords: SCFA; gut microbiota; mitochondria; nucleotides; short-chain fatty acids; vascularization