title: Action initiation shapes mesolimbic dopamine encoding of future rewards.
abstract: It is widely held that dopamine signaling encodes predictions of future rewards and such predictions are regularly used to drive behavior, but the relationship between these two is poorly defined. We found in rats that nucleus accumbens dopamine following a reward-predicting cue was attenuated unless movement was correctly initiated. Our results indicate that dopamine release in this region is contingent on correct action initiation and not just reward prediction.
authors.affiliation: Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.|Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.|Department of Experimental Psychology, University of Oxford, Oxford, UK.
authors.forename: Emilie C J
authors.initials: EC
authors.lastname: Syed
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford, UK.
authors.forename: Laura L
authors.initials: LL
authors.lastname: Grima
authors.affiliation: Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.
authors.forename: Peter J
authors.identifier: http://orcid.org/0000-0001-7141-7071
authors.initials: PJ
authors.lastname: Magill
authors.affiliation: Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.|Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.
authors.forename: Rafal
authors.initials: R
authors.lastname: Bogacz
authors.affiliation: Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.|Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Brown
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford, UK.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Walton
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D003463:Cues; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward; D015398:Signal Transduction
chemical_list: D004298:Dopamine