title: Ocular Surface Squamous Neoplasia in a Living-Related Conjunctival Limbal Allograft.
abstract: OBJECTIVE
  To report a single case of ocular surface squamous neoplasia (OSSN) that occurred in a living-related conjunctival limbal allograft (lr-CLAL).
  
  
  METHODS
  Case report and literature review.
  
  
  RESULTS
  A 70-year-old white man developed OSSN in a histocompatible identical lr-CLAL over 3 years after the surgical procedure. Incisional biopsy was performed, and topical interferon alpha-2b was initiated. Pathology results confirmed carcinoma in situ. After modest results with topical interferon alpha-2b, the patient was treated with excisional biopsy with mitomycin-C (0.04 mg/mL) and cryotherapy. Simultaneously, the lr-CLAL was replaced with a keratolimbal allograft of a deceased donor. The patient maintained 20/25 best-corrected visual acuity at last follow-up.
  
  
  CONCLUSIONS
  We present an unusual case of primary OSSN in a recipient of an lr-CLAL that was clinically confined to the borders of the graft.
authors.affiliation: *Department of Ophthalmology, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH; †Department of Medicine, Renal Transplant Division, University of Cincinnati, Cincinnati, OH; and ‡Department of Ophthalmology, Cincinnati Eye Institute/University of Cincinnati, Cincinnati, OH.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Shah
authors.forename: Gautham
authors.initials: G
authors.lastname: Mogilishetty
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Holland
mesh_terms: D000368:Aged; D064591:Allografts; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D002278:Carcinoma in Situ / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D003228:Conjunctiva / Q000473:pathology*; D003230:Conjunctival Neoplasms / Q000473:pathology* / Q000628:therapy; D017679:Cryotherapy; D004273:DNA, Neoplasm / Q000235:genetics; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D016850:Limbus Corneae; D019520:Living Donors; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D013508:Ophthalmologic Surgical Procedures; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000473:pathology
chemical_list: D000903:Antibiotics, Antineoplastic; D004273:DNA, Neoplasm; D016685:Mitomycin