title: New insights on diabetes and bone metabolism.
abstract: Diabetes mellitus is a common chronic metabolic disease worldwide whose prevalence has increased during the last decades. Besides its more commonly recognized complications, such as macrovascular disease, retinopathy, nephropathy and neuropathy, diabetes related bone disease has gained growing attention. Diabetic patients are more prone to fracture than the general population as well as to low turnover bone disease in the chronic kidney disease setting. In this review, we discuss the relationship between diabetes and bone as well as the pathogenesis of bone fragility in T2D.
authors.affiliation: Departamento de Clínica Médica e Serviço de Endocrinologia, Universidade Federal do Paraná, Brazil.
authors.forename: Carolina A
authors.initials: CA
authors.lastname: Moreira
authors.affiliation: Pontifícia Universidade Católica do Paraná, Brazil.
authors.forename: Fellype C
authors.initials: FC
authors.lastname: Barreto
authors.affiliation: Columbia University, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Dempster
mesh_terms: D001847:Bone Diseases / Q000453:epidemiology*; D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism*; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000453:epidemiology*; D050723:Fractures, Bone / Q000453:epidemiology; D006801:Humans; D015995:Prevalence