title: Polymeric Microneedle Array Fabrication by Photolithography.
abstract: This manuscript describes the fabrication of polymeric microneedle (MN) arrays by photolithography. It involves a simple mold-free process by using a photomask consisting of embedded micro-lenses. Embedded micro-lenses were found to influence MN geometry (sharpness). Robust MN arrays with tip diameters ranging between 41.5 µm ± 8.4 µm and 71.6 µm ± 13.7 µm, with two different lengths (1,336 µm ± 193 µm and 957 µm ± 171 µm) were fabricated. These MN arrays may provide potential applications in delivery of low molecular and macromolecular therapeutic agents through skin.
authors.affiliation: Department of Pharmacy, National University of Singapore.
authors.forename: Himanshu
authors.initials: H
authors.lastname: Kathuria
authors.affiliation: Department of Pharmacy, National University of Singapore.
authors.forename: Jaspreet Singh
authors.initials: JS
authors.lastname: Kochhar
authors.affiliation: Department of Pharmacy, National University of Singapore.
authors.forename: Michelle Hui Min
authors.initials: MH
authors.lastname: Fong
authors.affiliation: Singapore University of Technology and Design.
authors.forename: Michinao
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research (A*STAR).
authors.forename: Ciprian
authors.initials: C
authors.lastname: Iliescu
authors.affiliation: Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research (A*STAR); Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore; Mechanobiology Institute, National University of Singapore.
authors.forename: Hanry
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Pharmacy, National University of Singapore; lkang@nus.edu.sg.
authors.forename: Lifeng
authors.initials: L
authors.lastname: Kang