title: Role of Deubiquitinating Enzymes in DNA Repair.
abstract: Both proteolytic and nonproteolytic functions of ubiquitination are essential regulatory mechanisms for promoting DNA repair and the DNA damage response in mammalian cells. Deubiquitinating enzymes (DUBs) have emerged as key players in the maintenance of genome stability. In this minireview, we discuss the recent findings on human DUBs that participate in genome maintenance, with a focus on the role of DUBs in the modulation of DNA repair and DNA damage signaling.
authors.affiliation: Department of Cell Biology, Microbiology, and Molecular Biology, College of Arts and Sciences, University of South Florida, Tampa, Florida, USA ykee@usf.edu tony.huang@nyumc.org.
authors.forename: Younghoon
authors.initials: Y
authors.lastname: Kee
authors.affiliation: Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA ykee@usf.edu tony.huang@nyumc.org.
authors.forename: Tony T
authors.initials: TT
authors.lastname: Huang
mesh_terms: D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D006801:Humans; D015398:Signal Transduction; D025801:Ubiquitin / Q000378:metabolism; D064570:Ubiquitin-Specific Proteases / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D025801:Ubiquitin; D064570:Ubiquitin-Specific Proteases