title: A tri-serine tri-lactone scaffold for the quantification of citrate in urine.
abstract: Tri-serine tri-lactone based C3 symmetry fluorescent sensors were synthesized. Citrate is shown to bind to sensors, while displaying an increase in fluorescence intensity for the sensor with thiourea and a quenching for the sensor with sulfonamide. Information-rich responses of the sensors enable us to discriminate structurally similar anions, including mono-, di- and tri-carboxylates with 100% correct classification. A simple two-sensor array enables the determination of the concentration of citrate in urine without any sample preparation with high accuracy (error < 2%).
authors.affiliation: Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA. pavel@bgsu.edu.
authors.forename: Ali
authors.initials: A
authors.lastname: Akdeniz
authors.affiliation: Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA. pavel@bgsu.edu and Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey.
authors.forename: Mehmet Gokhan
authors.initials: MG
authors.lastname: Caglayan
authors.affiliation: Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA. pavel@bgsu.edu.
authors.forename: Pavel
authors.initials: P
authors.lastname: Anzenbacher
mesh_terms: D019343:Citric Acid / Q000652:urine*; D005453:Fluorescence; D007783:Lactones / Q000737:chemistry*; D012694:Serine / Q000737:chemistry*
chemical_list: D007783:Lactones; D019343:Citric Acid; D012694:Serine