title: Moxifloxacin versus Clindamycin/Ceftriaxone in the management of odontogenic maxillofacial infectious processes: A preliminary, intrahospital, controlled clinical trial.
abstract: BACKGROUND
  The aim of this study was to compare the days of hospitalization length between patients treated with Moxifloxacin with that of patients treated with a Clindamycin/Ceftriaxone combination and additionally, to isolate and identify the oral pathogens involved in orofacial odontogenic infections.
  
  
  METHODS
  A pilot-controlled-clinical-trial was carried out on hospitalized patients with cervicofacial odontogenic abscesses or cellulitis, who were randomly asigned to two study groups: 1) patients who received Moxifloxacin, and 2) patients receiving Clindamycin/Ceftriaxone combination. Infiltrate samples were collected through transdermic or transmucosal punction and later cultured on a media specific for aerobic and anaerobic microorganisms. Mean hospitalization duration in days until hospital discharge and susceptibility assessment in rates were established.
  
  
  RESULTS
  Mean hospitalization time in days of patients treated with Moxifloxacin was 7.0 ± 1.6 days, while in the Clindamycin/Ceftriaxone group, this was 8.4 ± 1.8 days, although significant difference could not be demonstrated (p=0.074). A total of 43 strains were isolated, all of these Gram-positive. These strains appeared to be highly sensitive to Moxifloxacin (97.5%) and Ceftriaxone (92.5%).
  
  
  CONCLUSIONS
  Moxifloxacin and Ceftriaxone appear to be potential convenient and rational alternatives to traditional antibiotics, for treating severe odontogenic infections, in conjunction with surgical extraoral incision, debridement, and drainage.
  
  
  BACKGROUND
  Orofacial odontogenic infections, antimicrobial susceptibility, antimicrobial resistance.
authors.affiliation: DDS, Resident, Department of Orofacial Surgery; Hospital "Ignacio Morones Prieto", San Luis Potosi, SLP, Mexico.
authors.forename: Hansel
authors.initials: H
authors.lastname: Gómez-Arámbula
authors.affiliation: DDS, Associate Professor, Department of Orofacial Surgery; Hospital "Ignacio Morones Prieto", San Luis Potosi, SLP, Mexico.
authors.forename: Antonio
authors.initials: A
authors.lastname: Hidalgo-Hurtado
authors.affiliation: DDS, Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, SLP, Mexico.
authors.forename: Rosaura
authors.initials: R
authors.lastname: Rodríguez-Flores
authors.affiliation: MS, Associate Professor, Biochemistry and Microbiology Laboratory, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, SLP, Mexico.
authors.forename: Ana-María
authors.initials: AM
authors.lastname: González-Amaro
authors.affiliation: DDS, MS, PhD, Associate Professor, Basic Sciencies Laboratory, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, SLP, Mexico.
authors.forename: Arturo
authors.initials: A
authors.lastname: Garrocho-Rangel
authors.affiliation: DDS, MS, PhD, Associate Professor, Basic Sciencies Laboratory, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, SLP, Mexico.
authors.forename: Amaury
authors.initials: A
authors.lastname: Pozos-Guillén