title: Long-term radiographic evaluation of risk factors related to implant treatment: suggestion for alternative statistical analysis of marginal bone loss.
abstract: OBJECTIVE
  Secular change in marginal bone loss (MBL), which is the index adopted for implant success criteria, has often been used to evaluate risk factors. However, the need to revise these criteria has recently been indicated due to rapid developments in implant treatment. The purpose of this study was to evaluate risk factors by analyzing MBL with an alternative statistical method.
  
  
  METHODS
  The analyses were performed on the outcomes of 366 patients with 1,902 implants during an average follow-up period of 84.8 months (with a maximum follow-up of 258 months). Instead of evaluating annual MBL, time was calculated as one of the explanatory variables because the correlation between MBL and time was small (correlation coefficient of 0.09010). Analysis of covariance (ANCOVA) was used for exploratory assessment of each factor, and multiple regression analysis was then utilized to identify risk factors. The multiple regression analysis was performed twice, once among all implants and another in which one implant per patient was randomly selected.
  
  
  RESULTS
  As a result of multiple regression analysis, smoking habits showed a significant effect on MBL. Age, sex, diabetes mellitus, implant positions, guided bone regeneration, and sinus floor elevation did not affect MBL. IMZ®implants were associated with significantly higher MBL than were ANKYLOS®and SPI®implants. There was no significant difference between Straumann®and other implants.
  
  
  CONCLUSIONS
  Our results showed that another statistical process, which eliminated the effect of time rather than comparing annual MBL, could be applied to evaluate MBL because the correlation between MBL and time was small.
authors.affiliation: Private Practice, Aichi, Japan. masa.hasegawa0202@gmail.com.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Hasegawa
authors.affiliation: Private Practice, Aichi, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Hotta
authors.affiliation: Graduate School of Economics, Keio University, Tokyo, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hoshino
authors.affiliation: Private Practice, Aichi, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Ito
authors.affiliation: Private Practice, Aichi, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Komatsu
authors.affiliation: Private Practice, Aichi, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Saito
mesh_terms: D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging*; D003627:Data Interpretation, Statistical; D015921:Dental Implants / Q000009:adverse effects*; D019232:Dental Restoration Failure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016348:Osseointegration; D011859:Radiography; D012044:Regression Analysis; D012307:Risk Factors; D059546:Sinus Floor Augmentation; D012907:Smoking / Q000009:adverse effects
chemical_list: D015921:Dental Implants
keywords: bone; clinical research; patient centered outcomes; radiology; regeneration; sinus floor elevation; smoking; statistics