title: Investigation on the association between NLRP3 gene polymorphisms and susceptibility to primary gout.
abstract: We conducted a case-control study to investigate the association between 3 common NALP3 polymorphisms (rs10754558, rs7512998, and rs12137901) and the susceptibility to primary gout. A total of 320 patients with primary gout and 320 controls were included in this study. The genotyping of NALP3 rs10754558, rs7512998, and rs12137901 were conducted by polymerase chain reaction-restriction fragment length polymorphism. Comparison analysis showed that primary gout patients were more likely to have higher body mass index, prevalence of hypertension, blood glucose, triglycerides, urea nitrogen, and uric acid (P < 0.05). Logistic regression analysis revealed no significant association between the NALP3 rs10754558, rs7512998, and rs12137901 polymorphisms and the risk of gouty arthritis. In conclusion, we found no significant association between NALP3 gene polymorphisms and the risk of primary gout.
authors.affiliation: Department of Rheumatology, Huaihe Hospital of Henan University, Kaifeng, China.
authors.forename: L F
authors.initials: LF
authors.lastname: Wang
authors.affiliation: Department of Rheumatology, Huaihe Hospital of Henan University, Kaifeng, China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Ding
authors.affiliation: Department of Rheumatology, Huaihe Hospital of Henan University, Kaifeng, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Nephropathy Rheumatology, Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006073:Gout / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D020641:Polymorphism, Single Nucleotide
chemical_list: D002352:Carrier Proteins; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human