title: The levels of the adipokines adipsin and leptin are associated with knee osteoarthritis progression as assessed by MRI and incidence of total knee replacement in symptomatic osteoarthritis patients: a post hoc analysis.
abstract: OBJECTIVE
  Limited studies have explored the association between adipokines and knee OA structural progression using quantitative MRI (qMRI), and very few have included total knee replacement (TKR) as a disease outcome. The objective of this study was to compare serum levels of five adipokines to cartilage volume loss (CVL) and investigate their predictive value for TKR.
  
  
  METHODS
  The according-to-protocol population (n = 138) of a knee OA trial was used. Serum levels of adipsin (complement factor D), leptin, adiponectin, resistin and serpin E1, and cartilage volume were determined at baseline and 24 months with specific ELISAs and qMRI, respectively. Study knee TKR incidence up to 4 years post-trial was also assessed.
  
  
  RESULTS
  Greater baseline values of adipsin and leptin correlated with increased CVL in the global knee and medial femur (P ⩽ 0.032) and of adipsin in the lateral compartment and femur (P ⩽ 0.028). Adiponectin showed an inverse correlation in the medial compartment and femur (P ⩽ 0.027). Resistin and serpin E1 were not associated with CVL. Multivariate analyses revealed that patients in the highest tertile at baseline of adipsin presented a greater odds ratio of CVL in the lateral compartment and femur (⩾2.87; P ⩽ 0.011), and those in the highest tertile of leptin in the medial compartment (2.78; P = 0.038). Most clinically relevant, patients in the highest tertile of adipsin or leptin at baseline had significantly greater incidence of TKR (P = 0.027).
  
  
  CONCLUSIONS
  Data demonstrate that both adipsin and leptin predict greater CVL over time in the lateral and medial compartment, respectively. Importantly, this study also demonstrates that higher baseline levels of adipsin or leptin are associated with higher incidence of TKR.
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Montreal, jm@martelpelletier.ca.
authors.forename: Johanne
authors.initials: J
authors.lastname: Martel-Pelletier
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Montreal.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Raynauld
authors.affiliation: StatSciences Inc, Notre-Dame de l'Île-Perrot and.
authors.forename: Marc
authors.initials: M
authors.lastname: Dorais
authors.affiliation: Medical Imaging Research & Development, ArthroLab Inc, Montreal, Quebec, Canada.
authors.forename: François
authors.initials: F
authors.lastname: Abram
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Montreal.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Pelletier
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002358:Cartilage, Articular / Q000473:pathology; D011416:Complement Factor D / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D020738:Leptin; C493488:CFD protein, human; D011416:Complement Factor D
keywords: MRI; adipokines; adiponectin; adipsin; leptin; osteoarthritis; total knee replacement