title: [Association of vitamin D receptor gene polymorphisms with mild cognitive impairment among elderly ethnic Uygurs].
abstract: OBJECTIVE
  To assess the association of vitamin D receptor gene (VDR) Apa I, Bsm I genotypes and allele frequencies and mild cognitive impairment (MCI) among elderly ethnic Uygurs from Xinjiang, China.
  
  
  METHODS
  The polymorphisms of the VDR genotypes (Apa I and Bsm I) were analyzed by the SNaPshot method in 124 MCI patients and 124 controls.
  
  
  RESULTS
  Factors which can increase the risk for MCI have included the A allele of the Apa I polymorphism [OR=1.62, 95%CI(1.13-2.31)] and the AA genotype [OR=3.49, 95% CI(1.57-7.74)], the T allele of the Bsm I polymorphism [OR=1.94, 95%CI(1.24-3.05)], higher triglyceride and systolic blood pressure levels.
  
  
  CONCLUSIONS
  Polymorphisms of the VDR gene including the A allele and AA genotype of Apa I, and the T allele of Bsm I are probably associated with MCI among elderly ethnic Uygurs, and so are higher levels of triglyceride and systolic blood pressure.
authors.affiliation: The First Department of Internal Medicine for Cadres, Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China. zhouxiaohui858@sina.com.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zhou
authors.forename: Meisheng
authors.initials: M
authors.lastname: Zhu
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: Haijun
authors.initials: H
authors.lastname: Miao
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001665:Binding Sites / Q000235:genetics; D001794:Blood Pressure; D002681:China; D060825:Cognitive Dysfunction / Q000208:ethnology / Q000235:genetics* / Q000523:psychology; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*; D014280:Triglycerides / Q000097:blood
chemical_list: D018167:Receptors, Calcitriol; D014280:Triglycerides; C053864:endodeoxyribonuclease BsmI; D015252:Deoxyribonucleases, Type II Site-Specific; C038485:GGGCCC-specific type II deoxyribonucleases