title: Bluetongue: Indian perspective.
abstract: Bluetongue (BT) is an insect borne (Culicoides) viral disease of small ruminants in India. While seroprevalence for BT is observed mostly in domestic and wild ruminant animals, the clinical form of disease and severe mortality is observed in sheep. Since the first report of BT in 1960s the country became endemic for the disease and most of the BT virus (BTV) serotypes (22 out of 27 worldwide) have been reported. The genome sequence analyses of these viruses revealed that both the eastern and western topotypes as well as their reassortant strains are present in India. It further revealed that some of these viruses are very close to live vaccines used in other countries. The severe economic concern justifies the need to develop sensitive and reliable diagnostic tests for BT. The virus isolation followed by identification by electron microscopy is gold standard test, but it is time consuming and not easily available in all the laboratories. Therefore, nucleic acid-based rapid diagnostic tests such as PCR, real-time PCR etc. are used nowadays. The BT control program in India includes vector control as well as effective vaccination. The vector population is controlled by vector traps, synthetic pesticides and some of the herbal compounds. For effective vaccination, the serotypes prevalent in a particular geographical area must be known, which can be achieved by continuous monitoring and sero-surveillance of disease. The multivalent inactivated vaccines are more suitable for India in comparison to modified live vaccines as the latter may turn to virulent and may lead to severe outbreak of the disease.
authors.forename: K
authors.initials: K
authors.lastname: Ranjan
authors.forename: P
authors.initials: P
authors.lastname: Minakshi
authors.forename: G
authors.initials: G
authors.lastname: Prasad
mesh_terms: D000818:Animals; D001819:Bluetongue / Q000635:transmission / Q000821:virology*; D001820:Bluetongue virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D002519:Ceratopogonidae / Q000821:virology; D007194:India; D007303:Insect Vectors / Q000821:virology
keywords: bluetongue virus; Culicoides; PCR; nucleic acid sequencing; India.