title: Serum leptin and adiponectin levels in children with type 1 diabetes mellitus - Relation to body fat mass and disease course.
abstract: OBJECTIVE
  Leptin and adiponectin are adipokines presenting a wide range of impacts, including glycemic balance regulations. Insulin is one of the main regulators of adipose tissue function. In type 1 diabetes mellitus (T1DM) endogenous insulin secretion is replaced by the exogenous supply, which is not regulated naturally. The aim of the study was to establish serum leptin and adiponectin levels, and their relations to body fat mass and disease course in children with T1DM.
  
  
  METHODS
  The study included 75 children with T1DM and the control group of 20 healthy coevals. All children had estimated serum leptin and adiponectin concentrations, lipid profile, and bioelectrical impedance analysis.
  
  
  RESULTS
  Serum leptin concentrations in children with T1DM were not significantly different from the control group (p=0.067, mean values±SD: 3.11±2.98 vs. 5.29±5.06μg/l, respectively), and related positively to body fat mass in both groups. Adiponectin serum concentrations were significantly higher in children with T1DM than in the control group (p<0.001; mean values: 18.82±9.31 vs. 12.10±5.53μg/ml, respectively), and were not related to the body fat content in the study group. Both, leptin and adiponectin, showed no relation to any of the analyzed parameters of the disease course.
  
  
  CONCLUSIONS
  Differences observed between children with T1DM and their healthy coevals, when similar in terms of age, body weight, and body fat mass, seem not to depend directly on the disease duration, its metabolic control or insulin supply.
authors.affiliation: Department of Clinical Auxology and Pediatric Nursing, Poznan University of Medical Sciences, Poznan, Poland; Department of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, Poznan, Poland. Electronic address: kswiton@poczta.onet.pl.
authors.forename: Katarzyna Anna
authors.initials: KA
authors.lastname: Majewska
authors.affiliation: Department of Rheumatology and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Dominik
authors.initials: D
authors.lastname: Majewski
authors.affiliation: Department of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Bogda
authors.initials: B
authors.lastname: Skowrońska
authors.affiliation: Department of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Witold
authors.initials: W
authors.lastname: Stankiewicz
authors.affiliation: Department of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Fichna
mesh_terms: D052242:Adiponectin / Q000097:blood*; D050154:Adiposity; D016022:Case-Control Studies; D002648:Child; D002784:Cholesterol / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D014280:Triglycerides / Q000097:blood
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D020738:Leptin; D014280:Triglycerides; D002784:Cholesterol
keywords: Adiponectin; Adipose tissue; Children; Leptin; Type 1 diabetes