title: Proteinuria as a surrogate marker for renal outcome: are we there yet?
abstract: Observational studies in glomerular diseases suggest that proteinuria reduction translates to improved outcomes. Because of a dearth of high-quality studies supporting this association, proteinuria is not universally recognized as a surrogate end point. Barbour et al. report on the longitudinal measure of proteinuria that best predicts hard renal outcomes. Their finding that time-varying proteinuria is the most reliable proteinuria metric is a necessary step in establishing proteinuria as a surrogate end point.
authors.affiliation: Columbia University Medical Center, New York, New York, USA.
authors.forename: Rupali S
authors.initials: RS
authors.lastname: Avasare
authors.affiliation: Columbia University Medical Center, New York, New York, USA.
authors.forename: Jai
authors.initials: J
authors.lastname: Radhakrishnan