title: Studies on anti-hyperglycemic effect of Euphorbia antiquorum L. root in diabetic rats.
abstract: OBJECTIVE
  To determine the anti-hyperglycemic effect of Euphorbia antiquorum L. root.
  
  
  METHODS
  The study evaluates the anti-hyperglycemic effect of E. antiquorum root in streptozotocin-nicotinamide-induced Type 2 diabetes mellitus and fructose-induced insulin resistance models. Alcohol and aqueous extracts of E. antiquorum root were administered at doses 200 and 400 mg/kg p.o. Serum levels of glucose, total cholesterol, triglycerides, glycosylated hemoglobin (GHb), and hepatic levels of malondialdehyde, glutathione, and glycogen were estimated.
  
  
  RESULTS
  Treatment with the alcohol and aqueous extracts of E. antiquorum roots resulted in significant (P < 0.001) lowering of serum blood glucose and GHb levels in both the models. Flavonoids, phenolic compounds, and glycosides were detected in the preliminary phytochemical screening.
  
  
  CONCLUSIONS
  Root of E. antiquorum showed promising anti-hyperglycemic effect which may be due to the presence of important phytochemicals.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, M. S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
authors.forename: Varadharajan
authors.initials: V
authors.lastname: Madhavan
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, M. S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
authors.forename: Anita
authors.initials: A
authors.lastname: Murali
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, M. S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
authors.forename: Doppalapudi Sree
authors.initials: DS
authors.lastname: Lalitha
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, M. S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
authors.forename: Sunkam
authors.initials: S
authors.lastname: Yoganarasimhan
keywords: Euphorbia antiquorum; hyperglycemia; insulin resistance; oxidative stress