title: [Clinical features and long-term outcome comparison of patients with midventricular obstructive hypertrophic cardiomyopathy and apical hypertrophic cardiomyopathy].
abstract: OBJECTIVE
  To compare the clinical features and long-term outcome of patients with midventricular obstructive hypertrophic cardiomyopathy (MVOHCM) and patients with apical hypertrophic cardiomyopathy (AHCM) in China.
  
  
  METHODS
  This retrospective study analyzed clinical data of 66 patients with MVOHCM and 263 patients with AHCM from a consecutive single-center cohort consisting of 2 413 patients with HCM. The clinical features, cardiovascular mortality and morbidity were compared between the two groups.
  
  
  RESULTS
  Compared with the AHCM, patients in the MVOHCM group was younger and more likely to be symptomatic over a mean follow-up of 7 years. The proportion of MVOHCM and AHCM were 2.7% (66/2 413) and 10.9% (263/2 413) (P < 0.001), respectively, in this cohort. Cardiovascular mortality of the two groups were 13.6% (9/66) and 0.8% (2/263) (P < 0.001), and cardiovascular morbidity of the two groups were 53.0% (35/66) and 14.4% (38/263) (P < 0.001).
  
  
  CONCLUSIONS
  MVOHCM is rarer, but the clinical manifestations and long-term outcomes are worse compared with AHCM in this patient cohort.
authors.affiliation: Key Laboratory of Clinical Trial Research in Cardiovascular Drugs, Ministry of Health Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, China.
authors.forename: Shuoyan
authors.initials: S
authors.lastname: An
authors.forename: Chi
authors.initials: C
authors.lastname: Cai
authors.forename: Fujian
authors.initials: F
authors.lastname: Duan
authors.forename: Yinjian
authors.initials: Y
authors.lastname: Yang
authors.forename: Xiying
authors.initials: X
authors.lastname: Guo
authors.forename: Yanling
authors.initials: Y
authors.lastname: Liu
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Liu
authors.forename: Lirong
authors.initials: L
authors.lastname: Yan
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Xu
authors.forename: Shihua
authors.initials: S
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Hua
authors.affiliation: Email: fred_fan2004@aliyun.com.
authors.forename: Chaomei
authors.initials: C
authors.lastname: Fan
authors.forename: Yishi
authors.initials: Y
authors.lastname: Li
mesh_terms: D002312:Cardiomyopathy, Hypertrophic; D006801:Humans; D012189:Retrospective Studies