title: ANTIPROLIFERATIVE ACTIVITY OF NOVEL ACETYLENIC DERIVATIVES OF BETULIN AGAINST G-361 HUMAN MELANOMA CELLS.
abstract: Acetylenic derivatives of betulin were tested in vitro for their antiproliferative activity against G-361 human melanoma cells. Two types of betulin derivatives were studied: monoesters, obtained by modification of the hydroxyl group at C-28 position, and diesters modified at both C-28 and C-3 positions. To assess cell proliferation, a colorimetric sulforhodamine B based method was used. All the tested monoesters inhibited cellular growth and 28-O-propynoylbetulin showed the strongest cytotoxic effect. Esterification of the C-3 hydroxyl group of the molecule abolished its growth inhibitory activity.
authors.forename: Ewa
authors.initials: E
authors.lastname: Bębenek
authors.forename: Ewa
authors.initials: E
authors.lastname: Chodurek
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Orchel
authors.forename: Zofia
authors.initials: Z
authors.lastname: Dzierżewicz
authors.forename: Stanisław
authors.initials: S
authors.lastname: Boryczka
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D000094042:Lupanes; D000094062:Betulinic Acid
chemical_list: D000970:Antineoplastic Agents; D014315:Triterpenes; C000589676:28-O-propynoylbetulin; D000094042:Lupanes; C002503:betulin; D000094062:Betulinic Acid