title: [Endocrine disruptors, reproduction and hormone-dependent cancers].
abstract: Endocrine disruptors are natural or synthetic chemical compounds which are present in the environment and which are able to interfere with hormonal regulation pathways and to induce human health deleterious effects. While their precise implication in human health and diseases is still matter of debates, it becomes likely that they have to be considered as risk factors in numerous chronic diseases: developmental and reproductive defects and hormone dependent cancers (present review), metabolic diseases (obesity and type 2 diabetes), neurodevelopmental or neurodegenerative diseases. Low doses exposure during critical windows of exposure such as foetal, perinatal and peri-pubertal periods, or chronic exposure with bioaccumulation in the adipose tissue, and possible synergic effects of several compounds ("cocktail effect") may participate to the genetic/environment interface suspected to participate to the pathophysiology of many diseases.
authors.affiliation: CHU de Nice, hôpital de l'Archet, service d'endocrinologie-diabétologie et reproduction, 062020 Nice cedex 3, France; Environnement, reproduction et cancers hormonodépendants, C3M Inserm U1065, équipe 5, hôpital de l'Archet, 062020 Nice cedex 3, France. Electronic address: fenichel.p@chu-nice.fr.
authors.forename: Patrick
authors.initials: P
authors.lastname: Fenichel
authors.affiliation: CHU de Nice, hôpital de l'Archet, service d'endocrinologie-diabétologie et reproduction, 062020 Nice cedex 3, France; Environnement, reproduction et cancers hormonodépendants, C3M Inserm U1065, équipe 5, hôpital de l'Archet, 062020 Nice cedex 3, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Brucker-Davis
authors.affiliation: CHU de Nice, hôpital de l'Archet, service d'endocrinologie-diabétologie et reproduction, 062020 Nice cedex 3, France; Environnement, reproduction et cancers hormonodépendants, C3M Inserm U1065, équipe 5, hôpital de l'Archet, 062020 Nice cedex 3, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Chevalier
mesh_terms: D052244:Endocrine Disruptors / Q000009:adverse effects*; D005260:Female; D005831:Genital Diseases, Female / Q000139:chemically induced; D005832:Genital Diseases, Male / Q000139:chemically induced; D006801:Humans; D008297:Male; D009376:Neoplasms, Hormone-Dependent / Q000139:chemically induced
chemical_list: D052244:Endocrine Disruptors