title: [Metformin and the obstetric patient].
abstract: Polycystic ovary syndrome (PCOS) is associated with insulin resistance, infertility, obesity and gestational complications. Metformin is widely used in fertility treatment of women with PCOS, due to a suggested positive effect of continued metformin treatment beyond the first trimester on pregnancy complications. Larger randomized trials have failed to confirm this. Metformin treatment has not been found to be superior to insulin treatment in women with gestational diabetes and may be associated with long-term consequences in the children in the form of overweight and disturbed glucose metabolism.
authors.affiliation: lauenborg@dadlnet.dk.
authors.forename: Katrine Dahl
authors.initials: KD
authors.lastname: Pedersen
authors.forename: Nathalie Søderhamn
authors.initials: NS
authors.lastname: Bülow
authors.forename: Kasper
authors.initials: K
authors.lastname: Aaboe
authors.forename: Julie
authors.initials: J
authors.lastname: Galsgaard
authors.forename: Helle Sand
authors.initials: HS
authors.lastname: Odgaard
authors.forename: Elisabeth Reinhardt
authors.initials: ER
authors.lastname: Mathiesen
authors.forename: Jeannet
authors.initials: J
authors.lastname: Lauenborg
mesh_terms: D001942:Breast Feeding; D016640:Diabetes, Gestational / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D008687:Metformin / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011297:Prenatal Exposure Delayed Effects
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin