title: Iron oxide nanoparticles protected by NIR-active multidentate-polymers as multifunctional nanoprobes for NIRF/PA/MR trimodal imaging.
abstract: We designed and synthesized new kinds of near-infrared catechol-based multidentate polymers which were intended to yield compact NIR-active iron oxide nanoparticles with excellent stability and biocompatibility. The resulted multifunctional nanoprobes showed great potential as multimodal contrast agents for NIRF/PA/MR trimodal imaging in vivo.
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
authors.forename: Yayun
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn and Bioimaging Core, Faculty of Health Sciences, University of Macau, Macao, China.
authors.forename: Duyang
authors.initials: D
authors.lastname: Gao
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn and Division of Biomedical Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, China. pzhangad@connect.ust.hk.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
authors.forename: Chuansheng
authors.initials: C
authors.lastname: Li
authors.affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wan
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
authors.forename: Chi
authors.initials: C
authors.lastname: Chen
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
authors.forename: Ping
authors.initials: P
authors.lastname: Gong
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
authors.forename: Guanhui
authors.initials: G
authors.lastname: Gao
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
authors.forename: Zonghai
authors.initials: Z
authors.lastname: Sheng
authors.affiliation: Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
authors.forename: Lintao
authors.initials: L
authors.lastname: Cai
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002396:Catechols / Q000737:chemistry; D003102:Colloids / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D008198:Lymph Nodes / Q000473:pathology; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D064847:Multimodal Imaging; D036103:Nanotechnology / Q000379:methods; D011108:Polymers / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D002396:Catechols; D003102:Colloids; D003287:Contrast Media; D005290:Ferric Compounds; D008024:Ligands; D011108:Polymers; C000499:ferric oxide; C034221:catechol