title: Impact of pore characteristics of silica materials on loading capacity and release behavior of ibuprofen.
abstract: Impact of pore characteristics of porous silica supports on loading capacity and release behavior of ibuprofen was investigated. The porous silica materials and ibuprofen-loaded porous silica materials were thoroughly characterized by N2-sorption, thermal gravimetric and derivative weight analyses (TG-DTW), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), transmission electron microscope (TEM) to determine the physical properties of materials, amount of ibuprofen adsorbed and position of ibuprofen. The detailed characterization reveals that the ibuprofen molecules adsorbed inside the mesopores. Increasing the mesopore size from 5nm to 10nm increased the ibuprofen loading from 0.74 to 0.85mmol/g, respectively. Incorporation of macropore into the structure of porous silica materials enhanced the ibuprofen loading capacity of 11.8-20.3%. The ibuprofen-loaded bimodal meso-macroporous silica materials exhibited the highest dissolution of 92wt.% within an hour. The ibuprofen particles deposited on the external surface of the porous silica materials showed a lower dissolution rate than the ibuprofen adsorbed inside the mesopores due to the formation of ibuprofen crystalline.
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Kasetsart University, Bangkok 10900, Thailand.
authors.forename: Thanapha
authors.initials: T
authors.lastname: Numpilai
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Kasetsart University, Bangkok 10900, Thailand; Center for Advanced Studies in Nanotechnology and Its Applications in Chemical Food and Agricultural Industries, Kasetsart University, Bangkok 10900, Thailand.
authors.forename: Suthaporn
authors.initials: S
authors.lastname: Muenmee
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Kasetsart University, Bangkok 10900, Thailand; Center for Advanced Studies in Nanotechnology and Its Applications in Chemical Food and Agricultural Industries, Kasetsart University, Bangkok 10900, Thailand; NANOTEC-KU-Center of Excellence on Nanoscale Materials Design for Green Nanotechnology, Kasetsart University, Bangkok 10900, Thailand. Electronic address: fengttwi@ku.ac.th.
authors.forename: Thongthai
authors.initials: T
authors.lastname: Witoon
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D007052:Ibuprofen / Q000737:chemistry / Q000493:pharmacokinetics; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D012822:Silicon Dioxide; D007052:Ibuprofen
keywords: Bimodal porous silica; Dissolution efficiency; Ibuprofen; Physical stability; Solid dispersion