title: Elucidation on enhanced application of synthesised kojic acid immobilised magnetic and chitosan tri-polyphosphate nanoparticles as antibacterial agents.
abstract: Kojic acid (KA) is a secondary metabolite which is secreted by several aspergillus species. It is a multi-functional skeleton from which many derivatives can be synthesised and applied in various areas of biotechnology. KA grafting on synthesised magnetic nanoparticles (MNPs) and chitosan tri-polyphosphate (chitosan-TPP) nanoparticles was successfully done and characterised by Fourier transformation infrared spectroscopy. It was observed that amino propyl triethoxy silane-coated MNPs and chitosan-TPP nanoparticles enhanced the antibacterial activity of KA against both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa). The organic constitution and significant antibacterial activity of KA-chitosan-TPP nanoparticles can be applicable in the field of medical biotechnology.
authors.affiliation: Amity Institute of Biotechnology, Amity University Rajasthan, NH-11C, Kant Kalwar, Jaipur 303002, Rajasthan, India. jigneshchaudhary23@rediffmail.com.
authors.forename: Jignesh
authors.initials: J
authors.lastname: Chaudhary
authors.affiliation: Amity Institute of Biotechnology, Amity University Rajasthan, NH-11C, Kant Kalwar, Jaipur 303002, Rajasthan, India.
authors.forename: Sudarshan
authors.initials: S
authors.lastname: Lakhawat
authors.affiliation: Amity Institute of Biotechnology, Amity University Rajasthan, NH-11C, Kant Kalwar, Jaipur 303002, Rajasthan, India.
authors.forename: Amrendra Nath
authors.initials: AN
authors.lastname: Pathak
mesh_terms: D000327:Adsorption; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D048271:Chitosan / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004339:Drug Compounding / Q000379:methods; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008422:Materials Testing; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry*; D011122:Polyphosphates / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D058185:Magnetite Nanoparticles; D053769:Nanocapsules; D011122:Polyphosphates; D048271:Chitosan; C005692:triphosphoric acid