title: The safety of drug treatments for cervical cancer.
abstract: BACKGROUND
  The treatment of some early-stage and most locally advanced disease cervical cancer patients consists of concurrent chemoradiation, while almost all with advanced disease require palliative chemotherapy.
  
  
  METHODS
  This review is aimed to analyze the safety issues emerging from trials of chemoradiation for early-stage high-risk disease and locally advanced stages, as well as safety issues of trials of palliative chemotherapy for advanced disease. Safety issues on fertility preservation are also discussed.
  
  
  CONCLUSIONS
  Cisplatin chemoradiation produces higher toxicity as compared to radiation alone, yet it is well-tolerated. Further advances would require (i) the development of more effective and tolerated combination chemoradiation regimens, (ii) demonstration of the efficacy and tolerability of adjuvant chemotherapy after cisplatin chemoradiation, and (iii) incorporation of targeted therapies into radiosensitizing regimens. A major problem continues to be the population of patients with advanced disease. The recent incorporation of bevacizumab into chemotherapy regimens represents a step forward; however, toxicity as well as economic issues may impede its wide acceptance worldwide. Preserving fertility in young women with cervical cancer is an issue that must be fully addressed. In this setting, neoadjuvant chemotherapy seems to increase fertlity rate without compromising oncological outcomes.
authors.affiliation: a Unit of Biomedical Research on Cancer , Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Cancerología , Mexico City , Mexico.|b Centro Oncológico Estatal , ISSEMyM , Toluca , Mexico.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Dueñas-González
authors.affiliation: c Division of Clinical Research , Instituto Nacional de Cancerología , Mexico City , Mexico.
authors.forename: Lucely
authors.initials: L
authors.lastname: Cetina
authors.affiliation: c Division of Clinical Research , Instituto Nacional de Cancerología , Mexico City , Mexico.
authors.forename: Jaime
authors.initials: J
authors.lastname: Coronel
authors.affiliation: c Division of Clinical Research , Instituto Nacional de Cancerología , Mexico City , Mexico.|d Division of Basic Research , Instituto Nacional de Cancerología , Mexico City , Mexico.
authors.forename: Aurora
authors.initials: A
authors.lastname: González-Fierro
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D059248:Chemoradiotherapy / Q000009:adverse effects / Q000379:methods; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects / Q000379:methods; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D020360:Neoadjuvant Therapy / Q000009:adverse effects / Q000379:methods; D009367:Neoplasm Staging; D010166:Palliative Care / Q000379:methods; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D002945:Cisplatin
keywords: Bevacizumab; cervical cancer; chemoradiation; fertility preservation; palliative chemotherapy; treatment safety