title: Synthesis and bioactivity of antitubercular peptides and peptidomimetics: an update.
abstract: Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), an infection that has been declared a global public health emergency by the World Health Organization. Current anti-TB therapies are limited in their efficacy and have failed to prevent the spread of TB, due to the long term drug compliance required and the genesis of multidrug-resistant strains (MDR). The number of chemotherapeutic agents currently available to treat MDR is limited, therefore there is a great need for new anti-TB drugs. Anti-TB peptides and peptidomimetics have emerged as an important and growing class of chemotherapeutic agents. This mini-review provides an update on peptides that exhibit very potent anti-TB activity, and their chemical syntheses, which could potentially be included in the pipeline for new anti-TB drug development.
authors.affiliation: School of Chemical Sciences, The University of Auckland, Auckland, New Zealand. m.brimble@auckland.ac.nz ldel990@aucklanduni.ac.nz.
authors.forename: Luis M
authors.initials: LM
authors.lastname: De Leon Rodriguez
authors.forename: Harveen
authors.initials: H
authors.lastname: Kaur
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Brimble
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D057786:Peptidomimetics / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology*; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D010455:Peptides; D057786:Peptidomimetics