title: Cigarette Smoking Effect on Survival After Lung Transplant in Cystic Fibrosis.
abstract: OBJECTIVE
  The effect of prior cigarette use by lung transplant donors and recipients on posttransplant survival is poorly defined, especially in subjects with cystic fibrosis. We sought to determine if donor or recipient cigarette smoking is associated with differential post lung transplant outcomes in cystic fibrosis patients, including survival.
  
  
  METHODS
  The United Network for Organ Sharing database was searched to analyze a large sample of cystic fibrosis patients with a history of lung transplant. The primary endpoint of the study was overall survival after transplant based on either recipient or donor history of smoking cigarettes.
  
  
  RESULTS
  There was a significant decrease in survival for cystic fibrosis patients who received lungs from a donor with a history of smoking (P = .026), but no difference in survival for recipients with a personal history of smoking. Nearly 60% of subjects who received lungs from a smoking donor died during the study. Donor smoking history was correlated with survival in a univariate (HR 1.2, [1.04-1.3 ]), but not multivariate model. Donor smoking history also was associated with increased treatment for rejection within the first year after transplant (P = .005).
  
  
  CONCLUSIONS
  More than 20 pack-year history of donor smoking may affect lung transplant outcomes (eg, survival and acute rejection) in patients with cystic fibrosis. Caution must be exercised when choosing suitable organ donors for cystic.
authors.affiliation: Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA.
authors.forename: Benjamin T
authors.initials: BT
authors.lastname: Kopp
authors.forename: Judith
authors.initials: J
authors.lastname: Groner
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Tobias
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Whitson
authors.forename: Stephen
authors.initials: S
authors.lastname: Kirkby
authors.forename: Don
authors.initials: D
authors.lastname: Hayes
mesh_terms: D003550:Cystic Fibrosis / Q000401:mortality* / Q000601:surgery*; D019992:Databases as Topic; D006801:Humans; D016040:Lung Transplantation; D012907:Smoking / Q000009:adverse effects*; D014019:Tissue Donors; D016896:Treatment Outcome