title: A Smart Antibacterial Surface for the On-Demand Killing and Releasing of Bacteria.
abstract: For various human healthcare and industrial applications, endowing surfaces with the capability to not only efficiently kill bacteria but also release dead bacteria in a rapid and repeatable fashion is a promising but challenging effort. In this work, the synergistic effects of combining stimuli-responsive polymers and nanomaterials with unique topographies to achieve smart antibacterial surfaces with on-demand switchable functionalities are explored. Silicon nanowire arrays are modified with a pH-responsive polymer, poly(methacrylic acid), which serves as both a dynamic reservoir for the controllable loading and release of a natural antimicrobial lysozyme and a self-cleaning platform for the release of dead bacteria and the reloading of new lysozyme for repeatable applications. The functionality of the surface can be simply switched via step-wise modification of the environmental pH and can be effectively maintained after several kill-release cycles. These results offer a new methodology for the engineering of surfaces with switchable functionalities for a variety of practical applications in the biomedical and biotechnology fields.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wei
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yu
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhan
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D057219:Biofouling / Q000517:prevention & control*; D020811:Biomedical Technology; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D006863:Hydrogen-Ion Concentration; D009113:Muramidase / Q000494:pharmacology*; D049329:Nanostructures / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry; D012825:Silicon; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D011108:Polymers; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid; D009113:Muramidase; D012825:Silicon
keywords: antibacterial surfaces; bacterial release; pH-responsive; silicon nanowire arrays