title: Cobalt-Catalyzed Carbonylative Cyclization of Pyridinyl Diazoacetates for the Synthesis of Pyridoisoquinolinones.
abstract: Dicobalt octacarbonyl-catalyzed carbonylative cyclization of pyridinyl diazoacetates is developed for the synthesis of pyridoisoquinolinones under mild conditions (room temperature) in a carbon monoxide atmosphere. Moreover, a synthetic method for various pyridoisoquinolinones from ethylpyridinyl aryl acetates is demonstrated through diazotization using TsN3 and DBU followed by Co-catalyzed carbonylation to generate ketene intermediates, which can subsequently undergo intramolecular cyclization under mild conditions in a carbon monoxide atmosphere in a semi-one-pot fashion.
authors.affiliation: National Creative Research Initiative Center for Catalytic Organic Reactions, Department of Chemistry, Kangwon National University , Chuncheon 200-701, Republic of Korea.
authors.forename: Yonghyeon
authors.initials: Y
authors.lastname: Baek
authors.affiliation: National Creative Research Initiative Center for Catalytic Organic Reactions, Department of Chemistry, Kangwon National University , Chuncheon 200-701, Republic of Korea.
authors.forename: Sunghwa
authors.initials: S
authors.lastname: Kim
authors.affiliation: National Creative Research Initiative Center for Catalytic Organic Reactions, Department of Chemistry, Kangwon National University , Chuncheon 200-701, Republic of Korea.
authors.forename: Bongkeun
authors.initials: B
authors.lastname: Jeon
authors.affiliation: National Creative Research Initiative Center for Catalytic Organic Reactions, Department of Chemistry, Kangwon National University , Chuncheon 200-701, Republic of Korea.
authors.forename: Phil Ho
authors.initials: PH
authors.lastname: Lee