title: Role of body composition and metabolic profile in Barrett's oesophagus and progression to cancer.
abstract: OBJECTIVE
  The aim of this study was to evaluate the risk for Barrett's oesophagus (BE) on the basis of body composition, metabolic pathways, adipokines and metabolic syndrome (MS), as well as their role in cancer progression.
  
  
  METHODS
  In patients with and without BE at gastroscopy, data on MS, BMI, waist/hip ratio for abdominal obesity (AO) and body fat percentage by bioimpedance were obtained. Fasting plasma glucose, insulin, HbA1c, lipid, serum adiponectin and leptin levels were measured. The homoeostasis model assessment (HOMA-IR) was used to estimate insulin resistance. Histological findings for BE were correlated with the above parameters. Risk factors for BE identified using univariate analysis were entered into a multivariate logistic regression analysis.
  
  
  RESULTS
  A total of 250 patients and 224 controls (F/M: 189/285, mean age 58.08±15.51 years) were enroled. In the BE and control groups, 39.6 versus 31.3% were overweight, 32 versus 22.8% were obese, 75.6 versus 51.3% had AO, and 28.1 versus 18.9% were metabolically obese, respectively. AO [odds ratio (OR) 3.08], increased body fat percentage (OR 2.29), and higher BMI (overweight: OR 2.04; obese: OR 2.26) were significantly associated with BE. A positive trend was found in Normal Weight Obese Syndrome (OR 1.69). MS was associated with BE (overweight: OR 3.05; obese: OR 5.2; AO: OR 8.08). Insulin levels (P=0.05) and HOMA-IR (P<0.001) were higher in BE. AO was the only independent risk factor associated with BE (OR 1.65; P=0.02) and high-grade dysplasia (OR 2.44) on multivariate analysis.
  
  
  CONCLUSIONS
  AO was strongly associated with BE and dysplasia. BE was associated with MS and higher insulin/HOMA-IR, suggesting the activation of specific metabolic pathways in patients with altered body composition.
authors.affiliation: Departments of aGastroenterology bMedicine, Centre for Obesity Research, University College London Hospital, London, UK cDepartment of Gastroenterology, Busto Arstizio Hospital, Milan dDepartment of Neuroscience, Tor Vergata University, Rome, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Di Caro
authors.forename: Wui Hang
authors.initials: WH
authors.lastname: Cheung
authors.forename: Lucia
authors.initials: L
authors.lastname: Fini
authors.forename: Margaret G
authors.initials: MG
authors.lastname: Keane
authors.forename: Belinda
authors.initials: B
authors.lastname: Theis
authors.forename: Rehan
authors.initials: R
authors.lastname: Haidry
authors.forename: Laura
authors.initials: L
authors.lastname: Di Renzo
authors.forename: Antonino
authors.initials: A
authors.lastname: De Lorenzo
authors.forename: Laurence
authors.initials: L
authors.lastname: Lovat
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Batterham
authors.forename: Matthew
authors.initials: M
authors.lastname: Banks
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000473:pathology; D054392:Adipokines / Q000097:blood; D050154:Adiposity; D000328:Adult; D000368:Aged; D001471:Barrett Esophagus / Q000453:epidemiology* / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D005773:Gastroscopy; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008131:London / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D008875:Middle Aged; D015999:Multivariate Analysis; D056128:Obesity, Abdominal / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D016017:Odds Ratio; D011230:Precancerous Conditions / Q000453:epidemiology* / Q000473:pathology; D015995:Prevalence; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D049629:Waist-Hip Ratio
chemical_list: D054392:Adipokines; D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D008055:Lipids; C517652:hemoglobin A1c protein, human