title: [Expression of phosphofructokinase 1 protein and it's enzyme activity on nasopharyngeal carcinoma].
abstract: OBJECTIVE
  The aim of this study is to investigate the expression of phosphofructokinase 1 and it's enzyme activity in nasopharyngeal carcinoma biopsy samples.
  
  
  METHODS
  Sixty-one biopsy samples were detected, including 41 tissues from patients with nasopharyngeal carcinoma as experimental group and 20 tissues from patients with chronic nasopharyngitis as control group. Phosphofructokinase 1 protein was detected by Western blot and it's enzyme activity was detected.
  
  
  RESULTS
  It was observed that the expression levels of phosphofructokinase 1 protein and it's enzyme activities in the experimental group were higher than that in the control group (P < 0.01). In the experimental group, the expression levels of phosphofructokinase 1 protein and it's enzyme activities in patients with lymph node metastasis were higher than that in patients without lymph node metastasis (P < 0.01).
  
  
  CONCLUSIONS
  Phosphofructokinase 1 may be a marker in occurrence and metastasis of nasopharyngeal carcinoma.
authors.forename: Shuo
authors.initials: S
authors.lastname: Li
authors.forename: Haiyu
authors.initials: H
authors.lastname: Hong
authors.forename: Zhengde
authors.initials: Z
authors.lastname: Du
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yang
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Gao
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001706:Biopsy; D002277:Carcinoma; D016022:Case-Control Studies; D006801:Humans; D008207:Lymphatic Metastasis; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000201:enzymology* / Q000473:pathology*; D009304:Nasopharyngitis; D010732:Phosphofructokinase-1 / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D010732:Phosphofructokinase-1