title: Some Important Milestones in the Field of Blood Clotting.
abstract: Several different kinds of 'milestone' in the field of blood coagulation are described from the middle decades of the 20th century. Although viewed from the standpoint of clotting per se, attention is also given to implications for innate immunity. The first milestone considered is the protracted saga of clotting dependence on vitamin K, an adventure that spanned more than five decades beginning in the 1920s. The second has to do with the discovery of a half-dozen 'new' clotting factors during the period immediately following World War II. A third pursues a narrower focus and examines the once mysterious transformation of fibrinogen into fibrin. Finally, the clinical treatment of classical hemophilia had a remarkable turning point in the 1960s as the result of simple but sensible measures.
authors.affiliation: Departments of Chemistry &amp; Biochemistry and Molecular Biology, University of California, San Diego, La Jolla, Calif., USA.
authors.forename: Russell F
authors.initials: RF
authors.lastname: Doolittle
mesh_terms: D001777:Blood Coagulation / Q000276:immunology*; D003450:Cryoglobulins / Q000378:metabolism; D005337:Fibrin / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006467:Hemophilia A / Q000628:therapy; D006801:Humans; D007113:Immunity, Innate; D014812:Vitamin K / Q000378:metabolism
chemical_list: D003450:Cryoglobulins; D014812:Vitamin K; D005337:Fibrin; D005340:Fibrinogen