title: Allosteric Modulators: A Side Door.
abstract: Allosteric modulators of the cannabinoid CB1 receptor were first discovered in 2005. Since then, although both negative and positive allosteric modulators have been uncovered, many questions remain about their site(s) of action, as well as the basis of their signaling. The described covalent probe with improved potency and efficacy will facilitate these studies.
authors.affiliation: Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University , 3500 N. Broad Street, Philadelphia, Pennsylvania 19140, United States.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Abood
mesh_terms: D000494:Allosteric Regulation / Q000187:drug effects*; D000495:Allosteric Site / Q000187:drug effects*; D006801:Humans; D008968:Molecular Conformation; D043884:Receptor, Cannabinoid, CB1 / Q000737:chemistry / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D043884:Receptor, Cannabinoid, CB1