title: Comparative Study of the Limitations and Challenges in Atom-Transfer C-H Oxidations.
abstract: A comparative study is disclosed that seeks to highlight the current limitations and challenges that exist in the field of atom-transfer C-H oxidations. State-of-the-art methods are benchmarked in order to showcase clear differences and similarities. A novel Mn-mediated method for C-H oxidation is disclosed that serves as a rapid and simple method for aliphatic C-H hydroxylation. Finally, two methods that allow for C-H oxidation in the presence of pyridine-containing substrates are studied, something that is rare in the field but of great interest to the chemical community.
authors.affiliation: Department of Chemistry, Stanford University , Stanford, California 94305, United States.
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Adams
authors.affiliation: Department of Chemistry, Stanford University , Stanford, California 94305, United States.
authors.forename: J
authors.initials: J
authors.lastname: Du Bois
authors.affiliation: Department of Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Inc. , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
authors.forename: Hasnain A
authors.initials: HA
authors.lastname: Malik