title: Exosomal miRNAs in Heart Disease.
abstract: Micro-RNAs (miRNAs) are small noncoding RNAs involved in the posttranscriptional regulation of gene expression. Exosomes have recently emerged as novel elements of intercellular communication in the cardiovascular system. Exosomal miRNAs could be key players in intercellular cross-talk, particularly during different diseases such as myocardial infarction (MI) and heart failure (HF). This review addresses the functional role played by exosomal miRNAs in heart disease and their potential use as new biomarkers.
authors.affiliation: Laboratory of Molecular and Cellular Cardiology, Cardiovascular Institute, Magna Graecia University, Catanzaro, Italy; and.
authors.forename: Claudio
authors.initials: C
authors.lastname: Iaconetti
authors.affiliation: Laboratory of Molecular and Cellular Cardiology, Cardiovascular Institute, Magna Graecia University, Catanzaro, Italy; and.
authors.forename: Sabato
authors.initials: S
authors.lastname: Sorrentino
authors.affiliation: Laboratory of Molecular and Cellular Cardiology, Cardiovascular Institute, Magna Graecia University, Catanzaro, Italy; and.
authors.forename: Salvatore
authors.initials: S
authors.lastname: De Rosa
authors.affiliation: Laboratory of Molecular and Cellular Cardiology, Cardiovascular Institute, Magna Graecia University, Catanzaro, Italy; and URT-CNR, Magna Graecia University, Catanzaro, Italy indolfi@unicz.it.
authors.forename: Ciro
authors.initials: C
authors.lastname: Indolfi
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002319:Cardiovascular System / Q000378:metabolism; D055354:Exosomes / Q000235:genetics*; D006331:Heart Diseases / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs