title: Predictors of Outcome and Hemorrhage in Patients Undergoing Endovascular Therapy with Solitaire Stent for Acute Ischemic Stroke.
abstract: BACKGROUND
  Endovascular mechanical thrombectomy is emerging as a promising therapeutic approach for acute ischemic stroke and show some advantages. However, the data of predicting clinical outcome after thrombectomy with Solitaire retriever were limited. We attempt to identify prognostic factors of clinical outcome in patients with acute ischemic stroke undergoing thrombectomy with Solitaire retriever.
  
  
  METHODS
  We conducted a retrospective analysis of consecutive acute ischemic strokes cases treated between December 2010 and December2013 where the Solitaire stent retriever was used for acute ischemic stroke. We assessed the effect of selected demographic characteristics, clinical factors on poor outcome at 3 months (modified Rankin score 3-6), mortality at 3 months, and hemorrhage within 24 h (symptomatic and asymptomatic). Clinical, imaging and logistic variables were analyzed. A multivariate logistic regression analysis was used to identify variables influencing clinical outcome, based on discharge NIHSS score change and mRS at 3 months.
  
  
  RESULTS
  Eighty nine consecutive patients with acute ischemic stroke underwent mechanical thrombectomy. Multivariate analysis revealed that admission NIHSS score, Serum glucose and endovascular procedure duration were independently associated with clinical outcome. Sex, NIHSS score at admission, diabetes and time of operation were associated with sICH in 1 day. NIHSS score ≥20 (OR 9.38; 95% CI 2.41-36.50), onset to reperfusion >5 hours (OR 5.23; 95% CI1.34,20.41) and symptomatic intracranial hemorrhage (OR 10.19; 95% CI1.80,57.83) were potential predictive factors of mortality at 3 months.
  
  
  CONCLUSIONS
  Multiple pre- and intra-procedural factors can be used to predict clinical outcome, symptomatic intracranial hemorrhage and mortality in acute ischemic stroke patients undergoing endovascular therapy. This knowledge is helpful for patients selection for endovascular mechanical thrombectomy.
authors.affiliation: Emergency Department, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
authors.forename: Shaowei
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Emergency Department, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Fei
authors.affiliation: Cerebral Vascular Disease Center, The First People's Hospital of Changzhou, Soochow University, Changzhou, 213003, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Department of Medical Imaging, The First People's Hospital of Changzhou, Soochow University, Changzhou, 213003, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Medical Imaging, The First People's Hospital of Changzhou, Soochow University, Changzhou, 213003, China.
authors.forename: You-Ran
authors.initials: YR
authors.lastname: Lu
authors.affiliation: Emergency Department, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
authors.forename: Hai-Rong
authors.initials: HR
authors.lastname: Wang
authors.affiliation: Emergency Department, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Chen
authors.affiliation: Emergency Department, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
authors.forename: Shuming
authors.initials: S
authors.lastname: Pan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications / Q000628:therapy*; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality; D057510:Endovascular Procedures / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D061185:Mechanical Thrombolysis / Q000009:adverse effects*; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015607:Stents / Q000009:adverse effects*; D020521:Stroke / Q000150:complications / Q000628:therapy*; D015996:Survival Rate; D017131:Thrombectomy / Q000009:adverse effects*; D055815:Young Adult