title: Effective screening for early diagnosis of pancreatic cancer.
abstract: Diagnosis of pancreatic cancer (PC) at an early stage with curative surgery should improve long-term patient outcome. At present, improving survival should lie in identifying those cases with high-risk factors or precursor lesions through an effective screening including ultrasonography, some biological markers, or national familial pancreatic cancer registration. Recently, cases with PC < 10 mm with a favorable prognosis have been reported. For the diagnoses of cases with PC < 10 mm, the rate of tumor detection was higher on endoscopic ultrasonography (EUS) than on CT or other modalities, and EUS-guided fine needle aspiration was helpful in confirming the histologic diagnosis. Additionally, for the diagnosis of cases with PC in situ, EUS and magnetic resonance cholangiopancreatography (MRCP) may play important roles in detecting the local irregular stenosis of the pancreatic duct. Cytodiagnosis of pancreatic juice using endoscopic nasopancreatic drainage multiple times may be useful in the final diagnosis.
authors.affiliation: Department of Gastroenterology, Onomichi General Hospital, 1-10-23, Hirahara, Onomichi, 722-8508, Japan. Electronic address: kh-ajpbd@nifty.com.
authors.forename: Keiji
authors.initials: K
authors.lastname: Hanada
authors.affiliation: Department of Gastroenterology, Onomichi General Hospital, 1-10-23, Hirahara, Onomichi, 722-8508, Japan. Electronic address: ak.from.coast@gmail.com.
authors.forename: Akihito
authors.initials: A
authors.lastname: Okazaki
authors.affiliation: Department of Gastroenterology, Onomichi General Hospital, 1-10-23, Hirahara, Onomichi, 722-8508, Japan. Electronic address: n.hirano@ebony.plala.or.jp.
authors.forename: Naomichi
authors.initials: N
authors.lastname: Hirano
authors.affiliation: Department of Gastroenterology, Onomichi General Hospital, 1-10-23, Hirahara, Onomichi, 722-8508, Japan. Electronic address: y.izumi1213@gmail.com.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Izumi
authors.affiliation: Department of Gastroenterology, Onomichi General Hospital, 1-10-23, Hirahara, Onomichi, 722-8508, Japan. Electronic address: t.minami@beach.ocn.ne.jp.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Minami
authors.affiliation: Department of Gastroenterology, Onomichi General Hospital, 1-10-23, Hirahara, Onomichi, 722-8508, Japan. Electronic address: ikejurichan@yahoo.co.jp.
authors.forename: Juri
authors.initials: J
authors.lastname: Ikemoto
authors.affiliation: Department of Gastroenterology, Onomichi General Hospital, 1-10-23, Hirahara, Onomichi, 722-8508, Japan. Electronic address: pinosuke84@yahoo.co.jp.
authors.forename: Kozue
authors.initials: K
authors.lastname: Kanemitsu
authors.affiliation: Department of Gastroenterology, Onomichi General Hospital, 1-10-23, Hirahara, Onomichi, 722-8508, Japan. Electronic address: h.fams@blue.megaegg.ne.jp.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Hino
mesh_terms: D001707:Biopsy, Needle; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000473:pathology; D004322:Drainage; D055088:Early Detection of Cancer / Q000379:methods*; D019160:Endosonography; D006801:Humans; D010189:Pancreatic Juice; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D047368:Tumor Burden
keywords: Early diagnosis of pancreatic cancer; Endoscopic nasopancreatic drainage (ENPD); Pancreatic cancer in situ (PCIS); Regional network; Risk factors