title: The efficacy of standard laxative use for the prevention and treatment of opioid induced constipation during oxycodone use: a small Dutch observational pilot study.
abstract: BACKGROUND
  Dutch clinical guidelines recommend that a standard laxative treatment (SLT) should be prescribed concomitantly when starting opioid treatment to prevent opioid-induced constipation (OIC).
  
  
  METHODS
  Clinical evidence for SLT in the treatment of OIC is lacking, therefore an observational pilot study was performed to explore the efficacy and tolerability of SLT on OIC in patients treated with the opioid oxycodone.
  
  
  RESULTS
  Twenty-four patients (58% female, median (range) age 65 (39-92)) were included in this pilot study. The analysis showed that 9 out of 21 patients (43%) were non-responders to SLT. When also taking into consideration patients tending to develop diarrhea 75% of patients are non-responsive to SLT.
  
  
  CONCLUSIONS
  This pilot study indicates that optimal laxative therapy (SLT) might not be effective and feasible for the prevention and treatment of OIC.
authors.affiliation: a Medical Department , Mundipharma Pharmaceuticals BV , Hoevelaken , The Netherlands.|b Center for Pain Medicine , Erasmus MC , Rotterdam , The Netherlands.
authors.forename: Gineke
authors.initials: G
authors.lastname: Koopmans-Klein
authors.affiliation: c Department of Anesthesiology and Pain Medicine , Reinier de Graaf , Delft , The Netherlands.
authors.forename: Michel F M
authors.initials: MF
authors.lastname: Wagemans
authors.affiliation: d Department of Anesthesiology, Academisch Medisch Centrum , University of Amsterdam , Amsterdam , the Netherlands.
authors.forename: Hans C H
authors.initials: HC
authors.lastname: Wartenberg
authors.affiliation: a Medical Department , Mundipharma Pharmaceuticals BV , Hoevelaken , The Netherlands.
authors.forename: Yvonne J B
authors.initials: YJ
authors.lastname: Van Megen
authors.affiliation: b Center for Pain Medicine , Erasmus MC , Rotterdam , The Netherlands.
authors.forename: Frank J P M
authors.initials: FJ
authors.lastname: Huygen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003248:Constipation / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control*; D003672:Defecation / Q000187:drug effects*; D003967:Diarrhea / Q000139:chemically induced; D005260:Female; D006801:Humans; D007422:Intestines / Q000187:drug effects* / Q000503:physiopathology; D054368:Laxatives / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009292:Narcotic Antagonists / Q000009:adverse effects*; D009426:Netherlands; D010098:Oxycodone / Q000009:adverse effects*; D010865:Pilot Projects; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D054368:Laxatives; D009292:Narcotic Antagonists; D010098:Oxycodone
keywords: Opioid induced constipation; laxatives; observational study; oxycodone; pilot study; real-life data