title: A comparative physicochemical, morphological and magnetic study of silane-functionalized superparamagnetic iron oxide nanoparticles prepared by alkaline coprecipitation.
abstract: The characterization of synthetic superparamagnetic iron oxide nanoparticle (SPION) surfaces prior to functionalization is an essential step in the prediction of their successful functionalization, and in uncovering issues that may influence their selection as magnetically targeted drug delivery vehicles (prodrugs). Here, three differently functionalized magnetite (Fe3O4) SPIONs are considered. All were identically prepared by the alkaline coprecipitation of Fe(2+) and Fe(3+) salts. We use X-ray photoelectron spectroscopy, electron microscopy, time-of-flight SIMS, FTIR spectroscopy and magnetic measurements to characterize their chemical, morphological and magnetic properties, in order to aid in determining how their surfaces differ from those prepared by Fe(CO)5 decomposition, which we have already studied, and in assessing their potential use as drug delivery carriers.
authors.affiliation: Laboratoire d'Innovation et d'Analyse de Bioperformance, École Polytechnique de Montréal, C.P. 6079, Succursale Centre-ville, Montréal, QC, Canada H3C 3A7. Electronic address: karina.mireles@polymtl.ca.
authors.forename: Laura-Karina
authors.initials: LK
authors.lastname: Mireles
authors.affiliation: Laboratoire d'Innovation et d'Analyse de Bioperformance, École Polytechnique de Montréal, C.P. 6079, Succursale Centre-ville, Montréal, QC, Canada H3C 3A7; Département de Génie physique, École Polytechnique de Montréal, C.P. 6079, Succursale Centre-ville, Montréal, QC, Canada H3C 3A7.
authors.forename: Edward
authors.initials: E
authors.lastname: Sacher
authors.affiliation: Laboratoire d'Innovation et d'Analyse de Bioperformance, École Polytechnique de Montréal, C.P. 6079, Succursale Centre-ville, Montréal, QC, Canada H3C 3A7.
authors.forename: L'Hocine
authors.initials: L
authors.lastname: Yahia
authors.affiliation: Department of General, Organic, Biomedical Chemistry, NMR and Molecular Imaging Laboratory, Université de Mons, 19 Avenue Maistriau, B-7000 Mons, Belgium; Center for Microscopy and Molecular Imaging (CMMI), B-6041 Gosselies, Belgium.
authors.forename: Sophie
authors.initials: S
authors.lastname: Laurent
authors.affiliation: Center for Microscopy and Molecular Imaging (CMMI), B-6041 Gosselies, Belgium.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Stanicki
mesh_terms: D055598:Chemical Phenomena; D011232:Chemical Precipitation; D006863:Hydrogen-Ion Concentration; D060328:Magnetic Phenomena; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*
chemical_list: D058185:Magnetite Nanoparticles; D012821:Silanes
keywords: Drug delivery; Magnetite; Superparamagnetic nanoparticles; Surface analysis; Surface reproducibility; Washing effect