title: American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline.
abstract: The purpose of the American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline is to provide recommendations to assist primary care and other clinicians in the care of female adult survivors of breast cancer. A systematic review of the literature was conducted using PubMed through April 2015. A multidisciplinary expert workgroup with expertise in primary care, gynecology, surgical oncology, medical oncology, radiation oncology, and nursing was formed and tasked with drafting the Breast Cancer Survivorship Care Guideline. A total of 1,073 articles met inclusion criteria; and, after full text review, 237 were included as the evidence base. Patients should undergo regular surveillance for breast cancer recurrence, including evaluation with a cancer-related history and physical examination, and should be screened for new primary breast cancer. Data do not support performing routine laboratory tests or imaging tests in asymptomatic patients to evaluate for breast cancer recurrence. Primary care clinicians should counsel patients about the importance of maintaining a healthy lifestyle, monitor for post-treatment symptoms that can adversely affect quality of life, and monitor for adherence to endocrine therapy. Recommendations provided in this guideline are based on current evidence in the literature and expert consensus opinion. Most of the evidence is not sufficient to warrant a strong evidence-based recommendation. Recommendations on surveillance for breast cancer recurrence, screening for second primary cancers, assessment and management of physical and psychosocial long-term and late effects of breast cancer and its treatment, health promotion, and care coordination/practice implications are made.This guideline was developed through a collaboration between the American Cancer Society and the American Society of Clinical Oncology and has been published jointly by invitation and consent in both CA: A Cancer Journal for Clinicians and Journal of Clinical Oncology. All rights reserved. No part of this document may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without written permission by the American Cancer Society or the American Society of Clinical Oncology.
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com.
authors.forename: Carolyn D
authors.initials: CD
authors.lastname: Runowicz
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com. corinne.leach@cancer.org.
authors.forename: Corinne R
authors.initials: CR
authors.lastname: Leach
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com.
authors.forename: N Lynn
authors.initials: NL
authors.lastname: Henry
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com.
authors.forename: Karen S
authors.initials: KS
authors.lastname: Henry
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com.
authors.forename: Heather T
authors.initials: HT
authors.lastname: Mackey
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com.
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Cowens-Alvarado
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com.
authors.forename: Rachel S
authors.initials: RS
authors.lastname: Cannady
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com.
authors.forename: Mandi L
authors.initials: ML
authors.lastname: Pratt-Chapman
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Edge
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com.
authors.forename: Linda A
authors.initials: LA
authors.lastname: Jacobs
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com.
authors.forename: Arti
authors.initials: A
authors.lastname: Hurria
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com.
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Marks
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com.
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: LaMonte
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com.
authors.forename: Ellen
authors.initials: E
authors.lastname: Warner
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com.
authors.forename: Gary H
authors.initials: GH
authors.lastname: Lyman
authors.affiliation: Carolyn D. Runowicz, Herbert Wertheim College of Medicine, Florida International University; Karen S. Henry, Sylvester Cancer Center at the University of Miami, Miami, FL; Corinne R. Leach, Rebecca L. Cowens-Alvarado, Rachel S. Cannady, and Samuel J. LaMonte, American Cancer Society, Atlanta, GA; N. Lynn Henry, University of Michigan, Comprehensive Cancer Center, Ann Arbor, MI; Heather T. Mackey, Oncology Nursing Society, Pittsburgh; Linda A. Jacobs, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mandi L. Pratt-Chapman, The George Washington University Cancer Institute, Washington, DC; Stephen B. Edge, Baptist Cancer Center, Memphis, TN; Arti Hurria, City of Hope, Duarte; Patricia A. Ganz, Schools of Medicine and Public Health, University of California, Los Angeles, CA; Lawrence B. Marks, University of North Carolina, Chapel Hill, NC; Ellen Warner, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; and Gary H. Lyman, Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA doi: 10.3322/caac.21319. Available online at cacancerjournal.com.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Ganz
mesh_terms: D001007:Anxiety / Q000188:drug therapy / Q000209:etiology; D001828:Body Image / Q000523:psychology; D001943:Breast Neoplasms / Q000150:complications* / Q000523:psychology* / Q000628:therapy; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000517:prevention & control; D003072:Cognition Disorders / Q000209:etiology; D003863:Depression / Q000188:drug therapy / Q000209:etiology; D005221:Fatigue / Q000209:etiology / Q000628:therapy; D005260:Female; D005817:Genetic Counseling; D006293:Health Promotion; D019584:Hot Flashes / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008019:Life Style; D008209:Lymphedema / Q000209:etiology / Q000628:therapy; D055118:Medication Adherence; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D010024:Osteoporosis / Q000188:drug therapy / Q000209:etiology; D059408:Pain Management; D010347:Patient Care Planning; D011159:Population Surveillance; D011320:Primary Health Care / Q000379:methods*; D012735:Sexual Dysfunction, Physiological / Q000209:etiology / Q000628:therapy; D017741:Survivors