title: Association of Inhaled Corticosteroids with Incident Pneumonia and Mortality in COPD Patients; Systematic Review and Meta-Analysis.
abstract: Inhaled corticosteroids are commonly prescribed for patients with severe COPD. They have been associated with increased risk of pneumonia but not with increased pneumonia-associated or overall mortality.
  
  
  
  To further examine the effects of inhaled corticosteroids on pneumonia incidence, and mortality in COPD patients, we searched for potentially relevant articles in PubMed, Medline, CENTRAL, EMBASE, Scopus, Web of Science and manufacturers' web clinical trial registries from 1994 to February 4, 2014. Additionally, we checked the included and excluded studies' bibliographies. We subsequently performed systematic review and meta-analysis of included randomized controlled trials and observational studies on the topic.
  
  
  
  We identified 38 studies: 29 randomized controlled trials and nine observational studies. The estimated unadjusted risk of pneumonia was increased in randomized trials: RR 1.61; 95% CI 1.35-1.93, p < 0.001; as well as in observational studies: OR 1.89; 95% CI 1.39-2.58, p < 0·001. Six randomized trials and seven observational studies were useful in estimating unadjusted risk of pneumonia -case-fatality: RR 0.91; 95% CI 0.52-1.59, p = 0.74; and OR 0.72; 95% CI 0.59-0.88, p = 0.001, respectively. Twenty-nine randomized trials and six observational studies allowed estimation of unadjusted risk of overall mortality: RR 0.95; 95% CI 0.85-1.05, p = 0.31; and OR 0.79; 95% CI 0.65-0.97, p = 0.02, respectively.
  
  
  
  Despite a substantial and significant increase in unadjusted risk of pneumonia associated with inhaled corticosteroid use, pneumonia fatality and overall mortality were found not to be increased in randomized controlled trials and were decreased in observational studies.
authors.affiliation: a Pulmonary and Critical Care Medicine , Mayo Clinic, Jacksonville , FL , USA.
authors.forename: Emir
authors.initials: E
authors.lastname: Festic
authors.affiliation: a Pulmonary and Critical Care Medicine , Mayo Clinic, Jacksonville , FL , USA.
authors.forename: Vikas
authors.initials: V
authors.lastname: Bansal
authors.affiliation: b Internal Medicine, University of Florida/SHANDS , Jacksonville , FL , USA.
authors.forename: Ena
authors.initials: E
authors.lastname: Gupta
authors.affiliation: c Pulmonary and Critical Care Medicine, Mayo Clinic , Rochester , MN , USA.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Scanlon
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D009026:Mortality; D064887:Observational Studies as Topic; D011014:Pneumonia / Q000453:epidemiology* / Q000401:mortality; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic
chemical_list: D000305:Adrenal Cortex Hormones
keywords: bias; case-fatality; drop-out; heterogeneity