title: The co-expression of MMP-9 and Tenascin-C is significantly associated with the progression and prognosis of pancreatic cancer.
abstract: BACKGROUND
  Matrix metalloproteinase-9 (MMP-9) and Tenascin-C (TN-C) have been shown to be involved in the metastasis of many tumors. The purpose of this study was to determine the relationship between the co-expression of these two molecules and the clinical prognosis of pancreatic cancer.
  
  
  METHODS
  We investigated the expression of TN-C and MMP-9 in 103 pancreatic cancer tissues by immunohistochemistry and used statistical analyses to investigate the correlations of individual expression or co-expression of these two molecules with clinicopathological parameters and survival of pancreatic cancer.
  
  
  RESULTS
  The expression of MMP-9 and TN-C were increased in pancreatic cancer. The co-expression of MMP-9 and TN-C was also detected. The expression of MMP-9 and TN-C were correlated with vascular invasion, lymph node invasion, liver metastases and TNM stage. The co-expression of MMP-9 and TN-C was significantly related to the pancreatic cancer metastases. The individual overexpression of MMP-9 or TN-C significantly decreased the overall survival rates. The co-expression of MMP-9 and TN-C had the lowest overall survival rates. The co-expression of MMP-9 and TN-C was an independent predictor of survival for pancreatic cancer patients.
  
  
  CONCLUSIONS
  Co-expression of MMP-9 and TN-C was associated with poorer prognosis and was found to be an independent predictor of survival.
authors.affiliation: Department of Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, China. xuyingqiangtmmu@163.com.
authors.forename: Yingqiang
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, China. tmmublesslee@outlook.com.
authors.forename: Zhonghu
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, China. cqsyz_99@126.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Jiang
authors.affiliation: Department of Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, China. cqxnyywg@163.com.
authors.forename: Guo
authors.initials: G
authors.lastname: Wu
authors.affiliation: Department of Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, China. tmmuchenkai@gmail.com.
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.affiliation: Department of Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, China. bbcyisheng@163.com.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, China. lixw1966@163.com.|, No.30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China. lixw1966@163.com.
authors.forename: Xiaowu
authors.initials: X
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008198:Lymph Nodes / Q000378:metabolism*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D011379:Prognosis; D019063:Tenascin / Q000378:metabolism*
chemical_list: D019063:Tenascin; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9