title: Phase-dependent changes in local dynamic stability during walking in elderly with and without knee osteoarthritis.
abstract: Previously, we reported reduced time-averaged knee local stability, in the unaffected, but not the affected leg of elderly with knee osteoarthritis OA compared to controls. Since stability may show phase-related changes, we reanalyzed the dataset reported previously using time-dependent local stability, λ(t), and also calculated time-averaged local stability, λs, for comparison. We studied treadmill walking at increasing speeds, focusing on sagittal plane knee movements. 16 patients, 12 healthy peers and 15 young subjects were measured. We found a clear maximum in λ(t) (i.e. minimum in stability) at around 60% of the stride cycle (StanceMax λ(t)), a second clear maximum (SwingMax λ(t)) at around 95% followed by a minimum between 70% and 100% (SwingMin λ(t)). StanceMax λ(t) of both legs was significantly higher in the OA than the young control group. Values for healthy elderly fell between those of the other groups, were significantly higher than in young adults, but there was only a trend towards a significant difference with the StanceMax λ(t) of the OA group׳s affected side. Time-averaged and time-dependent stability measures within one leg were uncorrelated, while time-dependent stability measures at the affected side were inversely correlated with λs at the unaffected side. The results indicate that time-dependent local dynamic stability might provide a more detailed insight into the problems of gait stability in OA than conventional averaged local dynamic stability measures and support the notion that the paradoxical decline in unaffected side time-averaged local stability may be caused by a trade-off between affected and unaffected side stability.
authors.affiliation: Department of Rehabilitation Sciences, KU Leuven, Belgium.
authors.forename: Armaghan
authors.initials: A
authors.lastname: Mahmoudian
authors.affiliation: MOVE Research Institute Amsterdam, Faculty of Human Movement Sciences, VU University Amsterdam, The Netherlands; Department of Orthopedics, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, PR China.
authors.forename: Sjoerd M
authors.initials: SM
authors.lastname: Bruijn
authors.affiliation: Department of Physical Education, Yazd University, Iran.
authors.forename: Hamid Reza F
authors.initials: HRF
authors.lastname: Yakhdani
authors.affiliation: MOVE Research Institute Amsterdam, Faculty of Human Movement Sciences, VU University Amsterdam, The Netherlands; Orthopaedics Biomechanics Lab, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, PR China.
authors.forename: Onno G
authors.initials: OG
authors.lastname: Meijer
authors.affiliation: Department of Rehabilitation Sciences, KU Leuven, Belgium.
authors.forename: Sabine M P
authors.initials: SMP
authors.lastname: Verschueren
authors.affiliation: MOVE Research Institute Amsterdam, Faculty of Human Movement Sciences, VU University Amsterdam, The Netherlands. Electronic address: j.van.dieen@vu.nl.
authors.forename: Jaap H
authors.initials: JH
authors.lastname: van Dieen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005080:Exercise Test; D005260:Female; D005684:Gait; D006801:Humans; D007717:Knee; D007719:Knee Joint / Q000503:physiopathology*; D007866:Leg; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000503:physiopathology*; D016138:Walking; D055815:Young Adult
keywords: Gait; Gait stability; Knee osteoarthritis; Local divergence exponents