title: Experimental hypertension increases spontaneous intracerebral hemorrhages in a mouse model of cerebral amyloidosis.
abstract: Hypertension and cerebral amyloid angiopathy (CAA) are major risk factors for intracerebral hemorrhage (ICH); however the mechanisms of interplay between the two are not fully understood. We investigated the effect of hypertension in a transgenic mouse model with Alzheimer's-like pathology (Tg2576) treating them with angiotensin II and L-N(G)-nitroarginine methyl ester. A similar increase in systolic blood pressure was observed in both Tg2576 and control mice; however Tg2576 mice developed signs of stroke with a markedly shorter latency. Cerebral deposition of amyloid beta promotes the hypertension-induced ICH, thus supporting the notion that hypertension is a risk factor for ICH among patients with CAA.
authors.affiliation: Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA.
authors.forename: Giselle F
authors.initials: GF
authors.lastname: Passos
authors.affiliation: Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA.
authors.forename: Kelley
authors.initials: K
authors.lastname: Kilday
authors.affiliation: Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA Department of Statistics, University of California Irvine, Irvine, CA, USA.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Gillen
authors.affiliation: Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA cribbs@uci.edu vvasilev@uci.edu.
authors.forename: David H
authors.initials: DH
authors.lastname: Cribbs
authors.affiliation: Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA.
authors.forename: Vitaly
authors.initials: V
authors.lastname: Vasilevko
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000473:pathology; D016657:Cerebral Amyloid Angiopathy / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000473:pathology; D020299:Intracranial Hemorrhage, Hypertensive / Q000209:etiology* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides; D000804:Angiotensin II; D019331:NG-Nitroarginine Methyl Ester
keywords: Alzheimer’s disease; cerebral amyloid angiopathy; hypertension; intracerebral hemorrhage; risk factors