title: Fabrication of SnO2/porous silica/polyethyleneimine nanoparticles for pH-responsive drug delivery.
abstract: To create novel nanocarriers for achieving excellent drug delivery performance, pH-responsive fluorescent porous silica (PS) nanocarriers were developed by encapsulating SnO2 nanoparticles and coating polyethyleneimine (PEI) layer. SnO2/porous silica (SnO2/PS) nanoparticles have an average diameter of 80nm and center-radial large pore channels. The large channels endow them high surface area with a Brunauer-Emmett-Teller (BET) area of 939m(2)g(-1). Aspirin was used as test drug to evaluate the releasing behavior of SnO2/porous silica/polyethyleneimine (SnO2/PS/PEI) nanoparticles. Results indicated that aspirin can be successfully incorporated into the SnO2/PS/PEI nanoparticles and the SnO2/PS/PEI nanoparticles displayed excellent pH-responsive release. The release rate in pH7.4 buffer is higher than that in pH5.5 buffer, which attributed to the PEI structure change in varied pH buffer. In addition, the SnO2/PS/PEI nanoparticles presented novel drug-dependent fluorescence, which could be used to trace the drug release.
authors.affiliation: Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475004, PR China.
authors.forename: Na
authors.initials: N
authors.lastname: Cao
authors.affiliation: Key Laboratory of Plant Stress Biology, Henan University, Kaifeng 475004, PR China.
authors.forename: Miao
authors.initials: M
authors.lastname: Li
authors.affiliation: Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475004, PR China. Electronic address: yanbaozhao@126.com.
authors.forename: Yanbao
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475004, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Qiu
authors.affiliation: Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475004, PR China.
authors.forename: Xueyan
authors.initials: X
authors.lastname: Zou
authors.affiliation: Key Laboratory of Plant Stress Biology, Henan University, Kaifeng 475004, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475004, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Sun
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D017971:Tin Compounds / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D003692:Delayed-Action Preparations; D017971:Tin Compounds; D012822:Silicon Dioxide; D011094:Polyethyleneimine; C045358:stannic oxide
keywords: Drug delivery; Drug-dependent fluorescence; Nanocarriers; SnO(2)/porous silica/polyethyleneimine; pH-responsive