title: Reduced serum levels of syndecan-1 in patients with tongue squamous cell carcinoma.
abstract: To investigate soluble syndecan-1 (Sdc-1) in the sera of patients with tongue squamous cell carcinoma (SCC) and its correlation with the histopathological criteria of tumors.
  
  
  
  In a case-control study using a convenient method of sampling, 18 female and 25 male patients with confirmed diagnosis of tongue SCC, and 19 healthy females and 27 males were studied.
  
  
  
  Soluble Sdc-1 was measured in the sera of 43 patients with tongue SCC and was compared with that of healthy age-/sex-matched controls using a commercial enzyme-linked immunosorbent assay. Clinical and pathological data, along with the demographic characteristics of the patients, were recorded at the time of sampling.
  
  
  
  The levels of soluble Sdc-1 were decreased in the sera of patients compared to controls (91.17 ± 88.60 vs. 158.17 ± 103.47 ng/mL, P = .002). Although patients who smoke tended to have higher grades (P = .043), there was no significant difference in the level of syndecan-1 between smokers and non-smokers. A significant difference between syndecan-1 in the sera of patients with tumors of different stages was observed (Kruskal-Wallis test P=0.039); however, scarcity of patients in stages I and III decreased the power of the comparison.
  
  
  
  Sdc-1 levels in the sera of patients do not correlate with the tumor progression in the tongue SCC. This is in contrast with the reported inverse correlation between the expression level of membranous Sdc-1 and the histological grade and size of head and neck tumors. Therefore, Sdc-1 shedding may not be a major mechanism in the progressive loss of its expression regarding tongue tumor.
  
  
  
  NA Laryngoscope, 126:E191-E195, 2016.
authors.affiliation: Department of Immunology , School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad Sohrabi
authors.initials: MS
authors.lastname: Shegefti
authors.affiliation: Institute for Cancer Research , School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mahyar
authors.initials: M
authors.lastname: Malekzadeh
authors.affiliation: Department of Immunology , School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Malek-Hosseini
authors.affiliation: Department of Otolaryngology , School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Bijan
authors.initials: B
authors.lastname: Khademi
authors.affiliation: Department of Immunology , School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.|Institute for Cancer Research , School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Ghaderi
authors.affiliation: Department of Immunology , School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.|Institute for Cancer Research , School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mehrnoosh
authors.initials: M
authors.lastname: Doroudchi
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000097:blood*; D016022:Case-Control Studies; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053668:Syndecan-1 / Q000097:blood*; D014062:Tongue Neoplasms / Q000097:blood*
chemical_list: C508241:SDC1 protein, human; D053668:Syndecan-1
keywords: Syndecan-1; enzyme-linked immunosorbent assay; serum; tongue squamous cell carcinoma