title: Systemic sclerosis and calcinosis cutis: response to rituximab.
abstract: OBJECTIVE
  Calcinosis cutis (or cutaneous calcification) is a type of calcinosis wherein calcium deposits form in the skin and frequently encountered in limited cutaneous subtype of disease. So far, no treatment has shown an explicit beneficial effect. Medical therapy for calcinosis cutis with rituximab is limited and of variable benefit.
  
  
  METHODS
  Our patient was 54-year-old lady, a case of limited cutaneous scleroderma with widespread progressive calcinosis cutis unresponsive to current therapy. She went under treatment with rituximab with no successful outcome.
  
  
  CONCLUSIONS
  Results of therapy with rituximab on regression/improvement of systemic sclerosis-related calcinosis are limited and non-conclusive.
authors.affiliation: Scleroderma Study Group, Department of Rheumatology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Poormoghim
authors.affiliation: Scleroderma Study Group, Department of Rheumatology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: E
authors.initials: E
authors.lastname: Andalib
authors.affiliation: Department of Radiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: A R
authors.initials: AR
authors.lastname: Almasi
authors.affiliation: Scleroderma Study Group, Department of Rheumatology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: E
authors.initials: E
authors.lastname: Hadibigi
mesh_terms: D002114:Calcinosis / Q000188:drug therapy* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008875:Middle Aged; D000069283:Rituximab / Q000627:therapeutic use*; D012595:Scleroderma, Systemic / Q000188:drug therapy* / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D000069283:Rituximab
keywords: calcinosis; rituximab; systemic sclerosis