title: [Photothermal effects of metallic carbon nanotubes on human breast cancer cells].
abstract: SWNTs are a mixture of 1/3 metallic SWNTs (m-SWNTs) and 2/3 semiconducting SWNTs (s-SWNTs). It is desirable to separate the metallic SWNTs from the semi-conducting ones. In this study m-SWNTs was separated by using a poly[(m-phenylenevinylene)-alt-(p-phenylenevinylene)] (PmPV) derivative and used as photo-thermal media instead of SWNTs. The separation effects of m-SWNTs were evaluated by Raman spectra, molecular modeling and TEM images. The effects of m-SWNTs on MCF-7 cell proliferation and apoptosis were evaluated with MTT assay and flow cytometry, respectively. m-SWNTs were separated with high purity. A strong inhibition of MCF-7 cell growth was observed with the m-SWNTs under near-infrared (NIR) light irradiation. Our results will be helpful for the potential applications of m-SWNTs in clinical photothermal cancer therapy.
authors.forename: Jin
authors.initials: J
authors.lastname: Hou
authors.forename: Man
authors.initials: M
authors.lastname: Mi
authors.forename: Ming
authors.initials: M
authors.lastname: Wei
authors.forename: Wen-hui
authors.initials: WH
authors.lastname: Yi
mesh_terms: D017209:Apoptosis; D001943:Breast Neoplasms / Q000473:pathology*; D005434:Flow Cytometry; D006801:Humans; D008027:Light; D061986:MCF-7 Cells / Q000187:drug effects; D008958:Models, Molecular; D037742:Nanotubes, Carbon
chemical_list: D037742:Nanotubes, Carbon