title: Intrinsic effects of gold nanoparticles on proliferation and invasion activity in SGC-7901 cells.
abstract: Although biomedical applications of functionalized nanoparticles have taken significant strides, biological characterization of unmodified nanoparticles remains unclear. In the present study, we investigated the cell viability and invasion activity of gastric cancer cells after treatment with gold nanoparticles. The growth of SGC-7901 cells was inhibited significantly after treatment with 5-nm gold nanoparticles, and the cell invasion decreased markedly. These effects were not seen by different size gold nanoparticles (10, 20 and 40 nm). The attenuated invasion activity may be associated with the decreased expression of matrix metalloproteinase 9 and intercellular adhesion molecule-1. These data indicated that the response of SGC-7901 cells to gold nanoparticles was strongly associated with their unique size-dependent physiochemical properties. Therefore, we provided new evidence for the effect of gold nanoparticles on gastric cancer cell proliferation and invasion in vitro, making a contribution to the application of gold nanoparticles to novel therapies in gastric cancer.
authors.affiliation: Department of Cardiology, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China.
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Endocrinology, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China.
authors.forename: Zhongbao
authors.initials: Z
authors.lastname: Ruan
authors.affiliation: Department of Cardiology, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China.
authors.forename: Yigang
authors.initials: Y
authors.lastname: Yin
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006046:Gold / Q000008:administration & dosage; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis* / Q000235:genetics; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis* / Q000235:genetics; D053768:Metal Nanoparticles / Q000008:administration & dosage*; D009361:Neoplasm Invasiveness; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology
chemical_list: D018799:Intercellular Adhesion Molecule-1; D006046:Gold; D020780:Matrix Metalloproteinase 9