title: Percutaneous Transluminal Angioplasty Improved Posterior Reversible Encephalopathy Syndrome due to Renovascular Hypertension.
abstract: A 51-year-old man was admitted to our hospital complaining of preceding throbbing headache and tonic convulsions. Headache and convulsive seizure disappeared and his consciousness recovered to alert within 2 hours after onset. Neurological examination showed no abnormal findings. Laboratory examinations revealed high low-density lipoprotein cholesterol (179 mg/dL), renin (42 ng/mL/hour), aldosterone (265 pg/mL), noradrenaline (1031 pg/mL), and dopamine (79 pg/mL). In brain magnetic resonance imaging (MRI), fluid-attenuated inversion recovery, but not the diffusion-weighted image, showed high signal intensities in white matter in bilateral occipital, parietal, and frontal lobes, with no stenotic changes on magnetic resonance angiography. In addition, the diffusion coefficient of focal lesions was elevated. Decreasing blood flow velocity and separated lumens in the right renal artery trunk were shown by renal artery ultrasonography. Enhanced computed tomography and renal angiography showed right renal partial infarction and isolated stenosis in the right renal artery, accompanied by thrombosed false lumen. No stenotic changes were seen in other peripheral arteries. These findings seemed incompatible with renal dissection and fibromuscular dysplasia, Takayasu's arteritis, and polyarteritis nodosa. Our diagnosis was posterior reversible encephalopathy syndrome (PRES) induced by renal hypertension due to renal artery dissection. To improve the renal artery stenosis and secondary hypertension, we performed plain balloon angioplasty, in addition to administering antihypertensive and lipid-lowering medications. After angioplasty, hypertension and high signal intensity at brain MRI were clearly improved. We would like to emphasize that renal artery angioplasty should be considered as an option for patients with PRES and malignant hypertension.
authors.affiliation: Department of Neurology, Tokai University School of Medicine, Isehara, Kanagawa, Japan. Electronic address: a-mizuma@is.icc.u-tokai.ac.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizuma
authors.affiliation: Department of Neurology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Kouchi
authors.affiliation: Department of Neurology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors.forename: Taira
authors.initials: T
authors.lastname: Nakayama
authors.affiliation: Department of Neurology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors.forename: Shunya
authors.initials: S
authors.lastname: Takizawa
mesh_terms: D000450:Aldosterone / Q000097:blood; D017130:Angioplasty; D006801:Humans; D006978:Hypertension, Renovascular / Q000097:blood / Q000150:complications*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D054038:Posterior Leukoencephalopathy Syndrome / Q000097:blood / Q000209:etiology / Q000628:therapy*; D012083:Renin / Q000097:blood; D016896:Treatment Outcome
chemical_list: D008077:Lipoproteins, LDL; D000450:Aldosterone; D012083:Renin
keywords: Posterior reversible encephalopathy syndrome; angioplasty; renal artery; secondary hypertension