title: [Treatment and prognosis of solid pseudopapillary neoplasms with metastases or recurrence].
abstract: OBJECTIVE
  To describe the treatment and prognosis of solid pseudopapillary neoplasms (SPN) with metastases or recurrence.
  
  
  METHODS
  The clinical date of 24 patients with histological confirmed SPN with metastases or recurrence from January 2000 to April 2014 were retrospectively analyzed. There were 22 females and 2 males, with mean age of (36 ± 16) years. Fourteen patients had local recurrence or metastasis after surgery, with a mean time of recurrence (44 ± 29) months. Ten patients were defined SPN with distant metastasis at first admission. Nineteen patients underwent surgical resection, among them, 11 patients received complete resection. Nine cases underwent chemotherapy. Kaplan-Meier method was used to identify prognostic factors.
  
  
  RESULTS
  Twenty-four patients were followed-up, 9 patients died. Median survival time was 47 months, and 1-year, 3-year, and 5-year survival was 91.7%, 65.1%, 49.6%, respectively. Age (χ(2) = 6.858, P = 0.009), primary tumor diameter (χ(2) = 4.322, P = 0.038), extrahepatic metastasis (χ(2) = 5.279, P = 0.022) and complete resection of metastases and recurrence (χ(2) = 4.666, P = 0.031) were important prognostic factors for survival (P < 0.05).
  
  
  CONCLUSIONS
  For SPN with metastases or recurrence, good prognosis can also obtain after complete resection. Age, primary tumor diameter, extrahepatic metastasis and complete resection of metastases and recurrence are influence factors on prognosis of patients.
authors.affiliation: Department of Hepatobiliary Surgery, People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Mingyue
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Hepatobiliary Surgery, People's Liberation Army General Hospital, Beijing 100853, China; Email: shixianjie301@126.com.
authors.forename: Xianjie
authors.initials: X
authors.lastname: Shi
authors.affiliation: Department of Hepatobiliary Surgery, People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wan
authors.affiliation: Department of Hepatobiliary Surgery, People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Hongguang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Hepatobiliary Surgery, People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Lei
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Hepatobiliary Surgery, People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Mingyi
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Hepatobiliary Surgery, People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Yurong
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of Hepatobiliary Surgery, People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Jiahong
authors.initials: J
authors.lastname: Dong
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult