title: Effect of chromium picolinate and melatonin either in single or in a combination in high carbohydrate diet-fed male Wistar rats.
abstract: This study is designed to know the effects of chromium picolinate (CrPic) and melatonin (Mel) each alone and in a combination on high carbohydrate diet-fed (HCD-fed) male Wistar rats that exhibit insulin resistance (IR), hyperglycemia, and oxidative stress. Wistar rats have been categorized into five groups. Each group consisted of six male Wistar rats, control rats (group I), HCD (group II), HCD + CrPic (group III), HCD + Mel (group IV), and HCD + CrPic + Mel (group V). Insignificant differences were observed in serum levels of superoxide dismutase, nitric oxide, and zinc in group III, group IV, and group V when each group was compared with group II rats respectively. Significant differences were observed in group III, group IV, and group V when each group was compared with group II in homeostasis model assessment-estimated IR (P < 0.05, <0.0.05, <0.05), and in the levels of blood glucose (P < 0.05, <0.0.05, <0.05), total cholesterol (P < 0.05, <0.001, <0.001), triacylglycerols (<0.05, <0.001, <0.001), high density lipoprotein cholesterol (P < 0.05, <0.001, <0.001), malondialdehyde (P < 0.05, <0.05, <0.001), catalase (P <0.05, <0.05, <0.05), glutathione (P < 0.05, <0.05, <0.05), Mel (P < 0.05, <0.05, <0.001), and copper (P < 0.05, <0.05, < 0.001). In view of these results, HCD-fed male Wistar rats that are destined to attain IR and T2DM through diet can be prevented by giving CrPic and Mel administration in alone or in a combination.
authors.affiliation: Rajiv Gandhi Centre for Diabetes and Endocrinology, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
authors.forename: Zephy
authors.initials: Z
authors.lastname: Doddigarla
authors.affiliation: Rajiv Gandhi Centre for Diabetes and Endocrinology, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
authors.forename: Jamal
authors.initials: J
authors.lastname: Ahmad
authors.affiliation: Department of Zoology, Fish Molecular Biology and Endocrinology Laboratory, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
authors.forename: Iqbal
authors.initials: I
authors.lastname: Parwez
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004040:Dietary Carbohydrates / Q000009:adverse effects; D004338:Drug Combinations; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008550:Melatonin / Q000008:administration & dosage*; D018384:Oxidative Stress / Q000187:drug effects; D010848:Picolinic Acids / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004338:Drug Combinations; D010848:Picolinic Acids; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D008550:Melatonin; C030614:picolinic acid
keywords: Type 2 diabetes mellitus; chromium picolinate; copper; high carbohydrate diet; homeostasis model assessment-estimated insulin resistance; hyperglycemia; insulin resistance; melatonin