title: The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium.
abstract: Decades of research have established only a few etiological factors for glioma, which is a rare and highly fatal brain cancer. Common methodological challenges among glioma studies include small sample sizes, heterogeneity of tumor subtypes, and retrospective exposure assessment. Here, we briefly describe the Glioma International Case-Control (GICC) Study (recruitment, 2010-2013), a study being conducted by the Genetic Epidemiology of Glioma International Consortium that integrates data from multiple data collection sites, uses a common protocol and questionnaire, and includes biospecimen collection. To our knowledge, the GICC Study is the largest glioma study to date that includes collection of blood samples, which will allow for genetic analysis and interrogation of gene-environment interactions.
authors.forename: E Susan
authors.initials: ES
authors.lastname: Amirian
authors.forename: Georgina N
authors.initials: GN
authors.lastname: Armstrong
authors.forename: Renke
authors.initials: R
authors.lastname: Zhou
authors.forename: Ching C
authors.initials: CC
authors.lastname: Lau
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Claus
authors.forename: Jill S
authors.initials: JS
authors.lastname: Barnholtz-Sloan
authors.forename: Dora
authors.initials: D
authors.lastname: Il'yasova
authors.forename: Joellen
authors.initials: J
authors.lastname: Schildkraut
authors.forename: Francis
authors.initials: F
authors.lastname: Ali-Osman
authors.forename: Siegal
authors.initials: S
authors.lastname: Sadetzki
authors.forename: Christoffer
authors.initials: C
authors.lastname: Johansen
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
authors.forename: Robert B
authors.initials: RB
authors.lastname: Jenkins
authors.forename: Daniel
authors.initials: D
authors.lastname: Lachance
authors.forename: Sara H
authors.initials: SH
authors.lastname: Olson
authors.forename: Jonine L
authors.initials: JL
authors.lastname: Bernstein
authors.forename: Ryan T
authors.initials: RT
authors.lastname: Merrell
authors.forename: Margaret R
authors.initials: MR
authors.lastname: Wrensch
authors.forename: Faith G
authors.initials: FG
authors.lastname: Davis
authors.forename: Rose
authors.initials: R
authors.lastname: Lai
authors.forename: Sanjay
authors.initials: S
authors.lastname: Shete
authors.forename: Christopher I
authors.initials: CI
authors.lastname: Amos
authors.forename: Michael E
authors.initials: ME
authors.lastname: Scheurer
authors.forename: Kenneth
authors.initials: K
authors.lastname: Aldape
authors.forename: Irina
authors.initials: I
authors.lastname: Alafuzoff
authors.forename: Thomas
authors.initials: T
authors.lastname: Brännström
authors.forename: Helle
authors.initials: H
authors.lastname: Broholm
authors.forename: Peter
authors.initials: P
authors.lastname: Collins
authors.forename: Caterina
authors.initials: C
authors.lastname: Giannini
authors.forename: Marc
authors.initials: M
authors.lastname: Rosenblum
authors.forename: Tarik
authors.initials: T
authors.lastname: Tihan
authors.forename: Beatrice S
authors.initials: BS
authors.lastname: Melin
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Bondy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D015994:Incidence; D007391:International Cooperation; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology / Q000379:methods*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: cancer; case-control studies; glioblastoma; glioma; methodology; study profile