title: Trichodysplasia spinulosa: a polyomavirus infection specifically targeting follicular keratinocytes in immunocompromised patients.
abstract: Trichodysplasia spinulosa (TS) is a rare skin disease, caused by a specific polyomavirus, occurring in immunocompromised patients. The pathophysiological mechanisms of TS are not yet fully understood. By using polymerase chain reaction and skin biopsy immunostaining we report evidence, in a paediatric case, of follicular keratinocytes being the primary target of trichodysplasia spinulosa-associated polyomavirus.
authors.affiliation: Department of Dermatology, Université d'Auvergne, CHU Clermont-Ferrand Hôpital Estaing, 63003, Clermont-Ferrand, France.|Clermont-Ferrand Université, Université d'Auvergne, INSERM U990, Imagerie Moléculaire et Thérapie Vectorisée, 63000, Clermont-Ferrand, France.
authors.forename: J
authors.initials: J
authors.lastname: Rouanet
authors.affiliation: University of Franche Comté, EA3181, SFR FED 4234, Besançon, France.|University Hospital, Department of Dermatology, 25030, Besançon, France.
authors.forename: F
authors.initials: F
authors.lastname: Aubin
authors.affiliation: UMR INRA 1282 ISP, Faculté des Sciences Pharmaceutiques, 37200, Tours, France.
authors.forename: P
authors.initials: P
authors.lastname: Gaboriaud
authors.affiliation: UMR INRA 1282 ISP, Centre INRA Tours-Nouzilly, 37380, Nouzilly, France.
authors.forename: P
authors.initials: P
authors.lastname: Berthon
authors.affiliation: Department of Medical Microbiology, Leiden University Medical Center, PO Box 9600, 2300-RC, Leiden, The Netherlands.
authors.forename: M C
authors.initials: MC
authors.lastname: Feltkamp
authors.affiliation: Department of Paediatrics, CHU Clermont-Ferrand Hôpital Estaing, 63003, Clermont-Ferrand, France.
authors.forename: L
authors.initials: L
authors.lastname: Bessenay
authors.affiliation: UMR INRA 1282 ISP, Faculté des Sciences Pharmaceutiques, 37200, Tours, France.
authors.forename: A
authors.initials: A
authors.lastname: Touzé
authors.affiliation: UMR INRA 1282 ISP, Faculté des Sciences Pharmaceutiques, 37200, Tours, France.
authors.forename: J T J
authors.initials: JT
authors.lastname: Nicol
authors.affiliation: Department of Pathology, Université d'Auvergne, CHU Clermont-Ferrand Hôpital Estaing, 63003, Clermont-Ferrand, France.
authors.forename: F
authors.initials: F
authors.lastname: Franck
authors.affiliation: Department of Dermatology, Université d'Auvergne, CHU Clermont-Ferrand Hôpital Estaing, 63003, Clermont-Ferrand, France.|Clermont-Ferrand Université, Université d'Auvergne, INSERM U990, Imagerie Moléculaire et Thérapie Vectorisée, 63000, Clermont-Ferrand, France.
authors.forename: M
authors.initials: M
authors.lastname: D'Incan
mesh_terms: D002648:Child; D006201:Hair Diseases / Q000473:pathology / Q000821:virology; D018859:Hair Follicle / Q000473:pathology / Q000821:virology; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015603:Keratinocytes / Q000821:virology; D008297:Male; D009894:Opportunistic Infections / Q000150:complications* / Q000473:pathology; D027601:Polyomavirus Infections / Q000150:complications* / Q000473:pathology; D017193:Skin Diseases, Viral / Q000150:complications*
chemical_list: D007166:Immunosuppressive Agents