title: Improving cardiovascular protection: focus on a cardiovascular polypill.
abstract: Lack of adherence may explain, at least in part, the poor cardiovascular risk factors control observed in patients with ischemic heart disease, increasing the risk of developing new events. Polypill improves medication adherence, which may actually reduce blood pressure and LDL cholesterol compared with the drugs given separately. The fixed combination of acetylsalicylic acid 100 mg + ramipril 2.5, 5, or 10 mg + either simvastatin 40 mg or atorvastatin 20 mg is the unique cardiovascular polypill that has been registered in 22 countries worldwide. The polypill-containing simvastatin has been specifically tested in a clinical trial including only patients with ischemic heart disease. The FOCUS study showed that patients treated with the polypill showed a higher adherence compared with those receiving separate medications.
authors.affiliation: Department of Cardiology, University Hospital Ramon y Cajal, School of Medicine. University of Alcalá, Madrid, Spain.
authors.forename: Vivencio
authors.initials: V
authors.lastname: Barrios
authors.affiliation: Cardiology Department, University Hospital La Paz, Madrid, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Escobar
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage; D000069059:Atorvastatin / Q000008:administration & dosage; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D004338:Drug Combinations; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D055118:Medication Adherence; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D017257:Ramipril / Q000008:administration & dosage; D019821:Simvastatin / Q000008:administration & dosage
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010975:Platelet Aggregation Inhibitors; D000069059:Atorvastatin; D019821:Simvastatin; D017257:Ramipril; D001241:Aspirin
keywords: Trinomia®; adherence; cardiovascular risk factors; ischemic heart disease; polypill