title: The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke.
abstract: The clinical relevance of the transient intraluminal filament model of middle cerebral artery occlusion (tMCAO) has been questioned due to distinct cerebral blood flow profiles upon reperfusion between tMCAO (abrupt reperfusion) and alteplase treatment (gradual reperfusion), resulting in differing pathophysiologies. Positive results from recent endovascular thrombectomy trials, where the occluding clot is mechanically removed, could revolutionize stroke treatment. The rapid cerebral blood flow restoration in both tMCAO and endovascular thrombectomy provides clinical relevance for this pre-clinical model. Any future clinical trials of neuroprotective agents as adjuncts to endovascular thrombectomy should consider tMCAO as the model of choice to determine pre-clinical efficacy.
authors.affiliation: Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
authors.forename: Brad A
authors.initials: BA
authors.lastname: Sutherland
authors.affiliation: Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
authors.forename: Ain A
authors.initials: AA
authors.lastname: Neuhaus
authors.affiliation: Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Couch
authors.affiliation: Centre for Evidence Based Medicine, University of Oxford, Oxford, UK Norfolk and Norwich University Teaching Hospital NHS Trust, Norwich, UK.
authors.forename: Joyce S
authors.initials: JS
authors.lastname: Balami
authors.affiliation: Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
authors.forename: Gabriele C
authors.initials: GC
authors.lastname: DeLuca
authors.affiliation: Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
authors.forename: Gina
authors.initials: G
authors.lastname: Hadley
authors.affiliation: Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
authors.forename: Scarlett L
authors.initials: SL
authors.lastname: Harris
authors.affiliation: Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
authors.forename: Adam N
authors.initials: AN
authors.lastname: Grey
authors.affiliation: Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK alastair.buchan@medsci.ox.ac.uk.
authors.forename: Alastair M
authors.initials: AM
authors.lastname: Buchan
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D057510:Endovascular Procedures / Q000379:methods*; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology* / Q000601:surgery*; D017131:Thrombectomy / Q000379:methods*
keywords: Ischemic stroke; animal models; cerebral blood flow; endovascular thrombectomy; middle cerebral artery occlusion