title: Serological subsets of juvenile idiopathic inflammatory myopathies--an update.
abstract: In this review we explore the different characteristics of the serological phenotypes identified in juvenile-onset myositis and consider how the serological sub-classification of patients with juvenile myositis can be advantageous both in terms of reaching what can be a difficult diagnosis and informing on prognosis. Recent studies have described the autoantibody associated disease phenotypes and outcome for those with juvenile-onset disease and include analyses of large juvenile-onset myositis cohorts. Here we describe the autoantibody associated disease features for patients within juvenile-onset myositis in detail and discuss the expanding opportunities and strategies for myositis specific autoantibody testing in clinical practice.
authors.affiliation: a Royal National Hospital for Rheumatic Diseases , Bath , UK.|b Department of Pharmacy and Pharmacology , University of Bath , Bath , UK.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Tansley
authors.affiliation: a Royal National Hospital for Rheumatic Diseases , Bath , UK.|b Department of Pharmacy and Pharmacology , University of Bath , Bath , UK.
authors.forename: Neil J
authors.initials: NJ
authors.lastname: McHugh
mesh_terms: D000293:Adolescent; D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D003882:Dermatomyositis / Q000175:diagnosis*; D006801:Humans; D018482:Muscle, Skeletal / Q000276:immunology; D009220:Myositis / Q000175:diagnosis*; D011379:Prognosis; D012698:Serologic Tests
chemical_list: D001323:Autoantibodies
keywords: Autoantibody; juvenile; muscle disease; myositis; phenotype