title: Oxidative Stress and Antioxidant Levels in Patients with Anorexia Nervosa after Oral Re-alimentation: A Systematic Review and Exploratory Meta-analysis.
abstract: Oxidative stress markers seem to be higher in patients with anorexia nervosa (AN) than healthy controls, but the potentially beneficial effects of weight gain is not known. We calculated random effects standardised mean differences (SMDs) as effect size measures of oxidative stress marker changes after re-alimentation reported in two or more studies, summarising others descriptively. Seven longitudinal studies (n = 104) were included. After a median follow-up period of 8 weeks, AN patients significantly increased their body mass index (15.1 ± 2.1 to 17.1 ± 2.2, p < 0.0001). This weight gain was followed by a significant increase in serum levels of the antioxidant albumin (studies = 6, SMD = 0.50, 95%CI = 0.18; 0.82, p = 0.002; I(2) = 16%) and a significant decrease in the oxidative stress marker Apolipoprotein B (studies = 2, n = 19, SMD = -0.85, 95%CI = -1.53; -0.17, p = 0.01; I(2) = 0). In one study, catalase and total antioxidant capacity increased, whilst superoxide dismutase significantly decreased. In conclusion, oral re-alimentation, even without full-weight normalisation, seems to improve oxidative stress in people with AN.
authors.affiliation: Department of Neurosciences, University of Padova, Padova, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Solmi
authors.affiliation: Department of Medicine-DIMED, Geriatrics Section, University of Padova, Padova, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Veronese
authors.affiliation: Department of Pathology, University of Verona, Verona, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Luchini
authors.affiliation: Department of Medicine-DIMED, Geriatrics Section, University of Padova, Padova, Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: Manzato
authors.affiliation: Department of Medicine-DIMED, Geriatrics Section, University of Padova, Padova, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Sergi
authors.affiliation: Department of Neurosciences, University of Padova, Padova, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Favaro
authors.affiliation: Department of Neurosciences, University of Padova, Padova, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Santonastaso
authors.affiliation: Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY, 11004, USA.|Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA.|The Feinstein Institute for Medical Research, Manhasset, NY, USA.|Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Christoph U
authors.initials: CU
authors.lastname: Correll
mesh_terms: D000418:Albumins / Q000378:metabolism; D000856:Anorexia Nervosa / Q000097:blood*; D000975:Antioxidants / Q000378:metabolism*; D053299:Apolipoprotein B-100 / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000097:blood; D006801:Humans; D008137:Longitudinal Studies; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood; D015430:Weight Gain
chemical_list: C569471:APOB protein, human; D000418:Albumins; D000975:Antioxidants; D053299:Apolipoprotein B-100; D015415:Biomarkers; D002374:Catalase; D013482:Superoxide Dismutase
keywords: ApoB; albumin; anorexia nervosa; antioxidant; oxidative stress; refeeding; weight gain