title: [Genetic polymorphism of FMO3 and its role in drug metabolism and toxicity].
abstract: The flavin-containing monooxygenase 3 (FMO3) is an important hepatic microsomal enzyme. Numerous mutations of FMO3 gene have been reported, and polymorphic varients of the gene have been identified. Several studies indicated that variability in the expression of FMO3 involved in some nitrogen, or sulfur-containing durg metabolism. This review summarizes the genetic polymorphism of FMO3 and its role in drug metabolism and toxicity.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Gong
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
mesh_terms: D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D010105:Oxygenases / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D010105:Oxygenases; C020066:dimethylaniline monooxygenase (N-oxide forming)