title: Intraoperative acridine orange photodynamic therapy and cribriform electron-beam irradiation for canine intranasal tumors: A pilot study.
abstract: Untreated canine intranasal tumors carry a poor prognosis. We retrospectively evaluated the efficacy of marginal tumor resection in combination with intraoperative acridine orange (AO) photodynamic therapy (PDT) and 1 fraction of 5 Gy megavoltage irradiation for canine intranasal malignant tumors. When cribriform plate invasion or turbinate destruction around the cribriform plate was present, an additional fraction of 20 Gy was delivered with an electron beam during surgery. The study included 6 dogs, 2 of which were classified as stage I, 1 as stage II, and 3 as stage IV. The median local disease-free survival time and overall survival after the treatment were 8.5 and 13 months, respectively. Recurrence was noted in 2 of the 6 dogs after 4 and 7 months. Adverse events were mild (subcutaneous emphysema in 1 case, and rhinitis in 3 cases). Combination AO therapy may increase the tumor control time of dogs with marginally resectable intranasal malignant tumors.
authors.affiliation: Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan (Maruo, Fukuyama, Kawarai, Fujita); The University of Georgia, College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nemoto, Nakayama).
authors.forename: Takuya
authors.initials: T
authors.lastname: Maruo
authors.affiliation: Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan (Maruo, Fukuyama, Kawarai, Fujita); The University of Georgia, College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nemoto, Nakayama).
authors.forename: Koichi
authors.initials: K
authors.lastname: Nagata
authors.affiliation: Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan (Maruo, Fukuyama, Kawarai, Fujita); The University of Georgia, College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nemoto, Nakayama).
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fukuyama
authors.affiliation: Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan (Maruo, Fukuyama, Kawarai, Fujita); The University of Georgia, College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nemoto, Nakayama).
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nemoto
authors.affiliation: Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan (Maruo, Fukuyama, Kawarai, Fujita); The University of Georgia, College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nemoto, Nakayama).
authors.forename: Shinpei
authors.initials: S
authors.lastname: Kawarai
authors.affiliation: Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan (Maruo, Fukuyama, Kawarai, Fujita); The University of Georgia, College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nemoto, Nakayama).
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Fujita
authors.affiliation: Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan (Maruo, Fukuyama, Kawarai, Fujita); The University of Georgia, College of Veterinary Medicine, 501 D.W. Brooks Drive, Athens, Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nemoto, Nakayama).
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakayama
mesh_terms: D000165:Acridine Orange / Q000627:therapeutic use*; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D004285:Dogs; D005260:Female; D005456:Fluorescent Dyes / Q000627:therapeutic use*; D007430:Intraoperative Care / Q000662:veterinary; D008297:Male; D009669:Nose Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000662:veterinary*; D010778:Photochemotherapy / Q000662:veterinary*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D010865:Pilot Projects; D012189:Retrospective Studies
chemical_list: D005456:Fluorescent Dyes; D017319:Photosensitizing Agents; D000165:Acridine Orange