title: The use of fluorine-18 fluorodeoxyglucose positron emission tomography for imaging human motor neuronal activation in the brain.
abstract: The present study aimed to visualize human motor neuronal activation in the brain using fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET), and to develop an FDG-PET procedure for imaging neuronal activation. A male volunteer underwent 20 min periods of rest and motor activation, whilst being assessed using FDG-PET on two consecutive days. The motor task, which involved repetitively grasping and releasing the right hand, was performed during the initial 5 min of the activation period. Subtraction of the rest period signal from the activation PET images was performed using the subtraction ictal single-photon emission computed tomography co-registered to magnetic resonance imaging method. The subtracted image detected activation of the contralateral (left) primary motor cortex, supplementary motor area, and ipsilateral (right) cerebellum. In the present study, FDG-PET detected significantly increased motor-associated activation of the brain in a subject performing a motor task.
authors.affiliation: Department of Nuclear Medicine, Korea University Anam Hospital, Seoul 136-705, Republic of Korea.
authors.forename: Kisoo
authors.initials: K
authors.lastname: Pahk
authors.affiliation: Department of Neurology, Korea University Anam Hospital, Seoul 136-705, Republic of Korea.
authors.forename: Kun-Woo
authors.initials: KW
authors.lastname: Park
authors.affiliation: Department of Physical Medicine and Rehabilitation, Korea University Anam Hospital, Seoul 136-705, Republic of Korea.
authors.forename: Sung Bom
authors.initials: SB
authors.lastname: Pyun
authors.affiliation: Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea.
authors.forename: Jae Sung
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Korea University Anam Hospital, Seoul 136-705, Republic of Korea.
authors.forename: Sungeun
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Korea University Anam Hospital, Seoul 136-705, Republic of Korea.
authors.forename: Jae Gol
authors.initials: JG
authors.lastname: Choe
keywords: fluorodeoxyglucose positron emission tomography; motor cortex; motor cortex activation; motor image; neuroimaging