title: Interval colorectal carcinoma: An unsolved debate.
abstract: Colorectal carcinoma (CRC), as the third most common new cancer diagnosis, poses a significant health risk to the population. Interval CRCs are those that appear after a negative screening test or examination. The development of interval CRCs has been shown to be multifactorial: location of exam-academic institution versus community hospital, experience of the endoscopist, quality of the procedure, age of the patient, flat versus polypoid neoplasia, genetics, hereditary gastrointestinal neoplasia, and most significantly missed or incompletely excised lesions. The rate of interval CRCs has decreased in the last decade, which has been ascribed to an increased understanding of interval disease and technological advances in the screening of high risk individuals. In this article, we aim to review the literature with regard to the multifactorial nature of interval CRCs and provide the most recent developments regarding this important gastrointestinal entity.
authors.affiliation: Mark Benedict, Xuchen Zhang, Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, United States.
authors.forename: Mark
authors.initials: M
authors.lastname: Benedict
authors.affiliation: Mark Benedict, Xuchen Zhang, Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, United States.
authors.forename: Antonio
authors.initials: A
authors.lastname: Galvao Neto
authors.affiliation: Mark Benedict, Xuchen Zhang, Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, United States.
authors.forename: Xuchen
authors.initials: X
authors.lastname: Zhang
mesh_terms: D018256:Adenomatous Polyps / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D002277:Carcinoma / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D003111:Colonic Polyps / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D015994:Incidence; D011237:Predictive Value of Tests; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
keywords: Colorectal carcinoma; Detection; Interval colorectal carcinoma; Post colonoscopy colorectal cancer; Screening