title: Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreatic β-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus Patients.
abstract: Betatrophin and irisin are two recently identified hormones which may participate in regulating pancreatic β-cell function. However, the associations of these two hormones with β-cell function remain unclear. The present study aims to demonstrate the associations of circulating betatrophin and irisin levels with β-cell function, assessed by the area under the curve (AUC) of C-peptide, and the possible correlation between these two hormones in previously diagnosed type 2 diabetes mellitus (T2DM) patients. In total, 20 age-, sex-, and body mass index- (BMI-) matched normal glucose tolerance (NGT) subjects and 120 previously diagnosed T2DM patients were included in this study. Partial correlation analysis was used to evaluate the relationships between these two hormones and indexes of β-cell function and insulin resistance. Our results showed that betatrophin levels were significantly elevated, while irisin levels were significantly decreased, in patients with T2DM compared with NGT subjects. However, partial correlation analysis showed that betatrophin levels did not correlate with β-cell function-related variables or insulin resistance-related variables before or after controlling multiple covariates, while irisin correlated positively with insulin sensitivity but is not associated with β-cell function-related variables. Besides, no correlation was observed between betatrophin and irisin levels. Hence we concluded that betatrophin and irisin were not associated with β-cell function in previously diagnosed T2DM patients.
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Lingshu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Song
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Lin
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Liang
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Tianyi
authors.initials: T
authors.lastname: He
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Ruxing
authors.initials: R
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Qin
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Yiran
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Xinguo
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
mesh_terms: D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D002096:C-Peptide / Q000097:blood; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology*; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D050417:Insulin-Secreting Cells / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D036361:Peptide Hormones / Q000097:blood*
chemical_list: C576683:ANGPTL8 protein, human; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D002096:C-Peptide; C577593:FNDC5 protein, human; D005353:Fibronectins; D007328:Insulin; D036361:Peptide Hormones