title: [Association of rs13405728 polymorphism of LHR gene with slow ovarian response].
abstract: OBJECTIVE
  To assess the association of rs13405728 polymorphism of luteinizing hormone receptor (LHR) gene with slow ovarian response during assisted reproductive technology (ART).
  
  
  METHODS
  Two hundred and thirty-six women were enrolled and grouped according to their genotypes. The rs13405728 polymorphism was genotyped by DNA sequencing.
  
  
  RESULTS
  No signifiicant difference was found in antral follicle count and anti-Mullerian hormone between the three genotypes (P>0.05). The incidence of slow response in genotype GG was lower than in the other two genotypes (P<0.05). There was no significant difference in the amount of follicle stimulating hormone required, the number of follicles ≥14 mm on human chorionic gonadotrophin day, oocytes, mature oocytes, available embryos, and the clinical pregnancy rate among the three genotypes (P>0.05). There was an independent correlation between slow ovarian response with the genotypes of rs13405728, the initial dose of gonadotropin, and the dose of luteinizing hormone required (P<0.05).
  
  
  CONCLUSIONS
  Rs13405728 of the LHR gene may be associated with slow ovarian response in ART. Various mechanisms may be involved in the poor response and slow response.
authors.affiliation: Center for Reproductive Medicine, Xuzhou Central Hospital, Xuzhou, Jiangsu 221000, P.R. China. yangdz@mail.sysu.edu.cn.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Yin
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.forename: Jia
authors.initials: J
authors.lastname: Huang
authors.forename: Dongzi
authors.initials: D
authors.lastname: Yang
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D065851:Ovarian Reserve / Q000235:genetics*; D010062:Ovulation Induction / Q000379:methods; D020641:Polymorphism, Single Nucleotide; D011974:Receptors, LH / Q000235:genetics*; D027724:Reproductive Techniques, Assisted; D017422:Sequence Analysis, DNA / Q000379:methods
chemical_list: D011974:Receptors, LH