title: Unique features of long non-coding RNA biogenesis and function.
abstract: Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous biological processes across every branch of life. Although initially discovered as mRNA-like transcripts that do not encode proteins, recent studies have revealed features of lncRNAs that further distinguish them from mRNAs. In this Review, we describe special events in the lifetimes of lncRNAs - before, during and after transcription - and discuss how these events ultimately shape the unique characteristics and functional roles of lncRNAs.
authors.affiliation: Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California 94305, USA.|Department of Bioengineering, Stanford University School of Medicine and School of Engineering, Stanford, California 94305, USA.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Quinn
authors.affiliation: Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California 94305, USA.
authors.forename: Howard Y
authors.initials: HY
authors.lastname: Chang
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D005786:Gene Expression Regulation; D018392:Genomic Imprinting; D006801:Humans; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D034443:RNA Transport; D062085:RNA, Long Noncoding / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D002843:Chromatin; D062085:RNA, Long Noncoding