title: Serum 25-OH Vitamin D Level in Psoriatic Patients and Comparison With Control Subjects.
abstract: BACKGROUND
  Vitamin D has been shown to have immunomodulatory effects, and previous studies have proposed a role of vitamin D deficiency in multiple autoimmune diseases, including psoriasis.
  
  
  OBJECTIVE
  The aim of this study was to investigate serum vitamin D levels in psoriatic patients and compare them with levels in controls.
  
  
  METHODS
  This study was carried out in 50 psoriasis patients. Serum vitamin D was measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The mean serum vitamin D levels in psoriatic patients and controls were 14.92 ± 6.31 and 12.52 ± 4.54 ng/mL, respectively. The difference was not statistically significant (P = .06). The prevalence of vitamin D deficiency (<20 ng/mL) was 84.0% in psoriatic patients and 93.0% in controls (P = .21).
  
  
  CONCLUSIONS
  Most of the patients with psoriasis had vitamin D deficiency, which may have contributed to the evolution of their psoriasis. However, considering the high prevalence of vitamin D deficiency in Iran, no difference was noted between the psoriatic patients and the controls.
authors.affiliation: Cutaneous Leishmaniasis Research Centre, Department of Dermatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Maleki
authors.affiliation: Cutaneous Leishmaniasis Research Centre, Department of Dermatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran nahidiy@mums.ac.ir.
authors.forename: Yalda
authors.initials: Y
authors.lastname: Nahidi
authors.affiliation: Cutaneous Leishmaniasis Research Centre, Department of Dermatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Sahar
authors.initials: S
authors.lastname: Azizahari
authors.affiliation: Cutaneous Leishmaniasis Research Centre, Department of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Naser Tayyebi
authors.initials: NT
authors.lastname: Meibodi
authors.affiliation: Department of Biostatistics and Epidemiology, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Hadianfar
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000150:complications; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000150:complications
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Psoriasis Area and Severity Index (PASI); psoriasis; serum vitamin D