title: Protective efficacy of IFN-ω AND IFN-λs against influenza viruses in induced A549 cells.
abstract: The interferon system represents one of the components of the first line defence against influenza virus infection. Interferon omega (IFN-ω) is antigenetically different from IFN-α and IFN-β and can affect patients who are resistant to these IFNs. To improve the biological characterization of IFN-ω, we compared its activity with those of type I and type III IFNs in induced A549 cells. The antiviral effect on IFN-stimulated A549 cells was most apparent after infection with avian influenza virus. IFN-ω had statistically significant antiviral activity although less than IFN-β1a, IFN-λ1, or IFN-λ2. On the other hand, IFN-ω appeared more efficient than IFN-α2. Our results also indicate that IFN-λs were more suitable against human highly pathogenic virus. In this case, IFN-λ1 and IFN-λ2 were more potent than type I IFNs.
authors.forename: L
authors.initials: L
authors.lastname: Škorvanová
authors.forename: P
authors.initials: P
authors.lastname: Švančarová
authors.forename: D
authors.initials: D
authors.lastname: Svetlíková
authors.forename: T
authors.initials: T
authors.lastname: Betáková
mesh_terms: D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology / Q000502:physiology*; D053126:Influenza A Virus, H7N7 Subtype / Q000276:immunology / Q000502:physiology*; D007251:Influenza, Human / Q000276:immunology* / Q000821:virology; D007370:Interferon Type I / Q000276:immunology*; D007372:Interferons; D007378:Interleukins / Q000276:immunology*; D000095022:Interferon Lambda
chemical_list: D007370:Interferon Type I; D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C063743:interferon omega 1
keywords: influenza virus; interferon; replication; antiviral effect.