title: Two-week triple therapy has a higher Helicobacter pylori eradication rate than 1-week therapy: A single-center randomized study.
abstract: OBJECTIVE
  To evaluate a high effective and practical regimen for the eradication of Helicobacter pylori infection.
  
  
  METHODS
  The 298 patients with H. pylori infection, diagnosed by biopsies performed during the endoscopy, were randomized into two groups. Group 1: Treated for one week with a combination of omeprazole, amoxicillin, and clarithromycin (OAC), named by OAC-1 group (n = 143); Group 2: OAC-2 group (n = 155) treated for two weeks with OAC. The OAC-1 group was treated with triple therapy of omeprazole 20 mg, amoxicillin 1000 mg, and clarithromycin 500 mg bid for 1 week. OAC-2 group was treated likewise, but for two weeks. A 13C-urea breath test was used to monitor H. pylori after four to eight weeks following therapy.
  
  
  RESULTS
  The eradication of infection was 55% and 68% in the OAC-1 and OAC-2 groups, respectively. Moreover, the eradication rates in the two groups were 63% and 75%, respectively. Compared with the OAC-1 group, the efficacy of treatment in the OAC-2 group is significantly higher (P < 0.05).
  
  
  CONCLUSIONS
  Two-week OAC regimen yields a higher eradication rate of H. pylori, which might be a practical regimen for the eradication of H. pylori.
authors.forename: Jiaofeng
authors.initials: J
authors.lastname: Wang
authors.forename: Gansheng
authors.initials: G
authors.lastname: Zhang
authors.forename: Xiaona
authors.initials: X
authors.lastname: Hu
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Bao
authors.affiliation: Department of Gastroenterology, Huadong Hospital, Shanghai, China.
authors.forename: Yiqin
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D017291:Clarithromycin / Q000008:administration & dosage; D060740:Disease Eradication / Q000379:methods; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D057194:Intention to Treat Analysis / Q000379:methods; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage; D054328:Proton Pump Inhibitors / Q000008:administration & dosage; D016037:Single-Blind Method
chemical_list: D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors; D008795:Metronidazole; D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole