title: Reduced growth hormone signaling and methionine restriction: interventions that improve metabolic health and extend life span.
abstract: Interventions that improve health are often associated with longevity. Reduced growth hormone signaling has been shown to increase life span in mice by over 50%. Similarly, reductions in dietary intake of methionine, in rats and mice, result in life-span extension. Many factors affect metabolic health, mitochondrial function, and resistance to stressors, each of which influence aging and life span. This paper presents a comparison of these two interventions, as well as the results of a study combining these interventions, to understand potential mechanisms underlying their effectiveness in enhancing healthy aging.
authors.affiliation: Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota.
authors.forename: Holly M
authors.initials: HM
authors.lastname: Brown-Borg
mesh_terms: D000375:Aging; D000818:Animals; D031204:Caloric Restriction; D004734:Energy Metabolism; D013006:Growth Hormone / Q000378:metabolism*; D006262:Health; D008017:Life Expectancy; D008136:Longevity; D008715:Methionine / Q000378:metabolism*; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D023421:Models, Animal; D010641:Phenotype; D010766:Phosphorylation; D051381:Rats; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D013006:Growth Hormone; D008715:Methionine; D058570:TOR Serine-Threonine Kinases
keywords: diet restriction; growth hormone; longevity; metabolism; methionine