title: SYD-1 Promotes Multiple Developmental Steps Leading to Neuronal Connectivity.
abstract: The establishment of neuronal connectivity requires precise orchestration of multiple developmental steps, including axon specification, axon guidance, selection of synaptic target sites, and development of synaptic specializations. Although these are separate developmental steps, evidence indicates that some of the signaling molecules that regulate these steps are shared. In this review, we focus on SYD-1, a RhoGAP-like protein that has been implicated in each step of axonal development. We discuss interactions between SYD-1, UNC-40(DCC) and RhoGTPases and highlight both similarities and differences in how SYD-1 functions to regulate the different steps of axonal development. These observations reveal an example of how a signaling protein can be repurposed across sequential developmental steps.
authors.affiliation: Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, 53211, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, 53211, USA. quinnc@uwm.edu.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Quinn
mesh_terms: D000818:Animals; D000071437:Axon Guidance; D047108:Embryonic Development; D009415:Nerve Net / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010802:Phylogeny; D013569:Synapses / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins
keywords: Axon guidance; Netrin; Rho GTPases; SYD-1; Synaptogenesis; UNC-40