title: Analysis of Cerebrospinal Fluid Carbohydrate Antigen Series Biomarkers in Non-neoplastic Diseases.
abstract: BACKGROUND
  Carbohydrate antigen series biomarkers in cerebrospinal fluid (CSF) are important for the diagnosis of brain metastasis and meningeal carcinomatosis. Its relationship with CSF and serum in non-neoplastic diseases may be beneficial for earlier diagnosis and treatment.
  
  
  METHODS
  161 pairs of CSF and serum samples were obtained and compared. The 97.5th percentile and maximum value of carbohydrate antigen series biomarkers were obtained.
  
  
  RESULTS
  The 97.5th percentile and maximum value of CSF CA125, CA15-3 and CA19-9 concentration for overall participants was 4.31 u/ml and 4.59 u/ml, 2.01 and 3.65 u/ml, 2.71 u/ml and 3.00 u/ml, respectively. Gender had no significant effect on these three CSF biomarkers. The concentration of these three biomarkers in CSF were all lower than the paired serum concentration. The ratio of CA125, CA15-3 and CA19-9 level (CSF / serum) were from 0.018 to 0.69, 0.038 to 0.893, 0.017 to1, respectively.
  
  
  CONCLUSIONS
  Evaluation of intrathecal tumor markers synthesis is a specific, sensitive, reliable, and reproducible diagnostic tool. The values determined in this study of CSF carbohydrate antigen series biomarkers are significantly lower than what is usually used in clinical practice.
authors.affiliation: Department of Neurology, Hainan Branch of Chinese PLA General Hospital, Beijing, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shi
authors.affiliation: Department of Neurology, Hainan Branch of Chinese PLA General Hospital, Beijing, China.
authors.forename: Chenglin
authors.initials: C
authors.lastname: Tian
authors.affiliation: Department of Neurology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Xusheng
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Neurology, Chinese PLA General Hospital, Beijing, China shiq301@yeah.net.
authors.forename: Chuanqiang
authors.initials: C
authors.lastname: Pu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid*; D018394:CA-125 Antigen / Q000097:blood / Q000134:cerebrospinal fluid*; D018395:CA-19-9 Antigen / Q000097:blood / Q000134:cerebrospinal fluid*; D003711:Demyelinating Diseases / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood / Q000134:cerebrospinal fluid*; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid; D012016:Reference Values; D012851:Sinus Thrombosis, Intracranial / Q000097:blood / Q000134:cerebrospinal fluid; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins; D018396:Mucin-1
keywords: Carbohydrate antigen125; carbohydrate antigen 15-3; carbohydrate antigen 19-9; cerebrospinal fluid; serum