title: Myelin basic protein and ischemia modified albumin levels in acute ischemic stroke cases.
abstract: OBJECTIVE
  To investigate early diagnostic effects of serum myelin basic protein (MBP) and ischemic modified albumin (IMA) levels in patients with ischemic stroke.
  
  
  METHODS
  Fifty patients who presented to an emergency service with acute ischemic stroke between June 2013 to March 2014 were evaluated with the National Institute of Health Stroke Scale (NIHSS) and diffusion-weighted magnetic resonance imaging (MRI). Thirty four healthy cases were included as control group. All patients' serum IMA and MBP level were assessed.
  
  
  RESULTS
  Mean IMA value was 0.52±0.25 cases with acute ischemic stroke and serum IMA levels were significantly higher than the control group (p<0.01). No statistical significance was observed between acute ischemic stroke group and control group related to the MBP serum levels (P>0.05). Statistically significant correlation was detected between the volumes of diffusion restriction on MRI and NIHSS score (P=0.002, r=0.43) and IMA (P=0.015, r=0.344) levels.
  
  
  CONCLUSIONS
  We have found that serum IMA levels are elevated in acute ischemic stroke cases and these levels are correlated with the ischemic tissue volume. MBP levels do not increase in early period of stroke cases.
authors.affiliation: Serdar Can, MD. Departments of Emergency Medicine, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Can
authors.affiliation: Okhan Akdur, MD. Associate Professor, Departments of Emergency Medicine, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey.
authors.forename: Okhan
authors.initials: O
authors.lastname: Akdur
authors.affiliation: Ahmet Yildirim, MD. Assistant Professor, Departments of Emergency Medicine, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Yildirim
authors.affiliation: Gurhan Adam, MD. Assistant Professor, Departments of Radiology, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey.
authors.forename: Gurhan
authors.initials: G
authors.lastname: Adam
authors.affiliation: Dilek Ulker Cakir, MD. Associate Professor, Departments of Biochemistry, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey.
authors.forename: Dilek Ulker
authors.initials: DU
authors.lastname: Cakir
authors.affiliation: Handan Isin Ozisik Karaman, MD. Professor, Departments of Neurology, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey.
authors.forename: Handan Isin Ozisik
authors.initials: HI
authors.lastname: Karaman
keywords: Acute stroke; Cerebral Ischemia; Ischemia-modified serum albumin