title: A very rare case of breast cancer in a female-to-male transsexual.
abstract: The incidence of breast cancer in female-to-male (FTM) transsexuals who received mastectomy and sex reassignment surgery is very rare. In fact, there is only one previous medical report of such a case. We experienced a case of an FTM transsexual who developed breast cancer 12 years after mastectomy and hysterectomy with bilateral salpingo-oophorectomy. Because he had been continuously receiving testosterone during the last 15 years and because histopathological examination revealed positive estrogen receptor and androgen receptor expression, we suggest that exogenous testosterone may have initiated the development of breast cancer via two distinct pathways. We describe the clinical course and condition of the patient and recommend that medical personnel consider the possibility of hormone-related cancer in FTM transsexuals receiving cross-sex hormones.
authors.affiliation: Department of Plastic Surgery, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama-shi, Okayama, 700-8558, Japan. u_choppling@yahoo.co.jp.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Katayama
authors.affiliation: Department of Breast and Endocrinological Surgery, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama-shi, Okayama, 700-8558, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Motoki
authors.affiliation: Department of Plastic Surgery, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama-shi, Okayama, 700-8558, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Watanabe
authors.affiliation: Department of Plastic Surgery, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama-shi, Okayama, 700-8558, Japan.
authors.forename: Saiga
authors.initials: S
authors.lastname: Miho
authors.affiliation: Department of Plastic Surgery, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama-shi, Okayama, 700-8558, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kimata
authors.affiliation: Department of Breast and Endocrinological Surgery, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama-shi, Okayama, 700-8558, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Matsuoka
authors.affiliation: Department of Breast and Endocrinological Surgery, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama-shi, Okayama, 700-8558, Japan.
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Doihara
authors.affiliation: Department of Gender Center, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama-shi, Okayama, 700-8558, Japan.
authors.forename: Yuzaburo
authors.initials: Y
authors.lastname: Nanba
mesh_terms: D000328:Adult; D018567:Breast Neoplasms, Male / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D018278:Carcinoma, Neuroendocrine / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008297:Male; D013739:Testosterone; D014189:Transsexualism
chemical_list: D013739:Testosterone
keywords: Breast cancer; Hormone therapy; Transsexual