title: Multiple Functions of the Eya Phosphotyrosine Phosphatase.
abstract: Eyes absent (Eya), a protein conserved from plants to humans and best characterized as a transcriptional coactivator, is also the prototype for a novel class of eukaryotic aspartyl protein tyrosine phosphatases. This minireview discusses recent breakthroughs in elucidating the substrates and cellular events regulated by Eya's tyrosine phosphatase function and highlights some of the complexities, new questions, and surprises that have emerged from efforts to understand how Eya's unusual multifunctionality influences developmental regulation and signaling.
authors.affiliation: Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois, USA irebay@uchicago.edu.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Rebay
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005123:Eye / Q000737:chemistry / Q000201:enzymology* / Q000254:growth & development / Q000378:metabolism; D005136:Eye Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006657:Histones / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D017027:Protein Tyrosine Phosphatases / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D013379:Substrate Specificity; D015533:Transcriptional Activation
chemical_list: D005136:Eye Proteins; D006657:Histones; D017027:Protein Tyrosine Phosphatases