title: Efficacy of postoperative mitomycin-C eye drops on the clinical outcome in endoscopic dacryocystorhinostomy.
abstract: OBJECTIVE
  To evaluate the effect of postoperative topical mitomycin-C (MMC) eye drops in endoscopic (dacryocystorhinostomy) DCR and compare them with intraoperative MMC soaking.
  
  
  METHODS
  Retrospective, nonrandomized, interventional case series.
  
  
  METHODS
  One hundred and sixty cases of endoscopic DCR with a single surgeon for primary nasolacrimal duct obstruction (NLDO) were included. Cases were divided into three groups. Group 1 was treated with intraoperative application of 0.02 % MMC for 5 min. Group 2 was treated with 0.02 % MMC eye drops for 5 days after surgery, without intraoperative application of MMC. Group 3 was the control group of cases without the use of MMC. Each group was evaluated for surgical success, presence of complications including granuloma, synechiae, and tube-induced inflammation, and the adverse effect of the MMC at least 6 months after the surgery.
  
  
  RESULTS
  The success rate showed no significant difference among the three groups (P = .122, chi-square analysis). In the analysis between the two groups, although the success rate of Group 2 appeared not to be statistically different compared with that of Group 1 (P = .419, chi-square analysis), Group 2 had a statistically higher success rate for surgery than Group 3 (P = .041, chi-square analysis). The presence of granuloma was significantly lower in Group 1 than in the other two groups (P = .022, chi-square analysis). Synechiae and silicone tube-induced inflammation were not significantly different (P = .308, P = .881, chi-square analysis). There were no adverse effects associated with intraoperative or postoperative MMC application.
  
  
  CONCLUSIONS
  Use of postoperative topical 0.02 % MMC is a safe and effective adjunctive modality to increase the success rate of endoscopic DCR.
authors.affiliation: Department of Ophthalmology, Dongguk University Ilsan Hospital, 814, Siksadong, Ilsan-dong-gu, Koyang, Kyunggido, South Korea, 410-773.
authors.forename: Jae Rock
authors.initials: JR
authors.lastname: Do
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
authors.forename: Hwa
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
authors.forename: Sehyun
authors.initials: S
authors.lastname: Baek
authors.affiliation: Department of Ophthalmology, Nune Eye Hospital, Seoul, Republic of Korea.
authors.forename: Tae Soo
authors.initials: TS
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Dongguk University Ilsan Hospital, 814, Siksadong, Ilsan-dong-gu, Koyang, Kyunggido, South Korea, 410-773. mdjacob@dumc.or.kr.
authors.forename: Minwook
authors.initials: M
authors.lastname: Chang
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000477:Alkylating Agents / Q000008:administration & dosage*; D003608:Dacryocystorhinostomy; D004724:Endoscopy; D005260:Female; D006801:Humans; D007440:Intubation; D007767:Lacrimal Duct Obstruction / Q000628:therapy; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D009883:Ophthalmic Solutions; D011182:Postoperative Care; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000477:Alkylating Agents; D009883:Ophthalmic Solutions; D016685:Mitomycin
keywords: Dacryocystorhinostomy; Endoscopy; Mitomycin; Nasolacrimal duct