title: Enhanced amperometric detection of metronidazole in drug formulations and urine samples based on chitosan protected tetrasulfonated copper phthalocyanine thin-film modified glassy carbon electrode.
abstract: An enhanced electrocatalytic reduction of metronidazole antibiotic drug molecule using chitosan protected tetrasulfonated copper phthalocyanine (Chit/CuTsPc) thin-film modified glassy carbon electrode (GCE) has been developed. An irreversible reduction occurs at -0.47V (vs. Ag/AgCl) using Chit/CuTsPc modified GCE. A maximum peak current value is obtained at pH1 and the electrochemical reduction reaction is a diffusion controlled one. The detection limit is found to be 0.41nM from differential pulse voltammetry (DPV) method. This present investigation method is adopted for electrochemical detection of metronidazole in drug formulation and urine samples by using DPV method.
authors.affiliation: Department of Inorganic Chemistry, University of Madras, Guindy Campus, Chennai 600025, India.
authors.forename: S
authors.initials: S
authors.lastname: Meenakshi
authors.affiliation: Department of Inorganic Chemistry, University of Madras, Guindy Campus, Chennai 600025, India. Electronic address: jeevapandian@yahoo.co.uk.
authors.forename: K
authors.initials: K
authors.lastname: Pandian
authors.affiliation: Department of Rubber and Plastics Technology, MIT Campus, Anna University, Chennai 600044, India. Electronic address: jaya@mitindia.edu.
authors.forename: L S
authors.initials: LS
authors.lastname: Jayakumari
authors.affiliation: Sensor Division, Central Leather Research Institute (CLRI), CSIR, Adyar, Chennai 600020, India.
authors.forename: S
authors.initials: S
authors.lastname: Inbasekaran
mesh_terms: D002244:Carbon; D048271:Chitosan / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D004566:Electrodes; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D008795:Metronidazole / Q000032:analysis / Q000652:urine
chemical_list: D007211:Indoles; D008795:Metronidazole; C028418:tetrasulfophthalocyanine; D002244:Carbon; D003300:Copper; D048271:Chitosan
keywords: Chitosan; Differential pulse voltammetry; Metronidazole; Tetrasulfonated copper phthalocyanine; Urine samples