title: Killing cancer with platycodin D through multiple mechanisms.
abstract: Cancer is a multi-faceted disease comprised of a combination of genetic, epigenetic, metabolic and signalling aberrations which severely disrupt the normal homoeostasis of cell growth and death. Rational developments of highly selective drugs which specifically block only one of the signalling pathways have been associated with limited therapeutic success. Multi-targeted prevention of cancer has emerged as a new paradigm for effective anti-cancer treatment. Platycodin D, a triterpenoid saponin, is one the major active components of the roots of Platycodon grandiflorum and possesses multiple biological and pharmacological properties including, anti-nociceptive, anti-atherosclerosis, antiviral, anti-inflammatory, anti-obesity, immunoregulatory, hepatoprotective and anti-tumour activities. Recently, the anti-cancer activity of platycodin D has been extensively studied. The purpose of this review was to give our perspectives on the current status of platycodin D and discuss its anti-cancer activity and molecular mechanisms which may help the further design and conduct of pre-clinical and clinical trials to develop it successfully into a potential lead drug for oncological therapy. Platycodin D has been shown to fight cancer by inducing apoptosis, cell cycle arrest, and autophagy and inhibiting angiogenesis, invasion and metastasis by targeting multiple signalling pathways which are frequently deregulated in cancers suggesting that this multi-target activity rather than a single effect may play an important role in developing platycodin D into potential anti-cancer drug.
authors.affiliation: College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Khan
authors.affiliation: College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Amara
authors.initials: A
authors.lastname: Maryam
authors.affiliation: College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: He
authors.initials: H
authors.lastname: Zhang
authors.affiliation: College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Tahir
authors.initials: T
authors.lastname: Mehmood
authors.affiliation: College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Tonghui
authors.initials: T
authors.lastname: Ma
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004357:Drug Synergism; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D012503:Saponins / Q000494:pharmacology* / Q000627:therapeutic use; D014315:Triterpenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes; C108953:platycodin D
keywords: apoptosis; autophagy; invasion; metastasis; platycodin D; saponin