title: Factors Associated with Recruitment and Retention in Randomized Controlled Trials of Behavioral Interventions for Patients with Pediatric Type 1 Diabetes.
abstract: The purpose of this study is to describe recruitment and retention experiences from three behavioral randomized controlled trials conducted among youth with type 1 diabetes. Eligibility, recruitment, and retention data were examined. Study-specific differential study participation and loss-to-follow-up analyses assessed the relations of patient characteristics with treatment completion and 6-month retention. Multivariable logistic regression identified factors independently associated with 6-month retention among all participants. Approximately 70-92 % of randomized participants completed treatment and 58-90 % were retained for follow-up. Older patients and non-Caucasian patients were less likely to enroll. Treatment completion and 6-month retention were less likely among youth who were older, had worse baseline glycemic control, lower household income, and/or unmarried parents. Some subgroups of patients are less likely to participate in research and are more susceptible to loss-to-follow-up. More work is needed to understand the facilitators and barriers to research participation.
authors.affiliation: Center for Translational Science, Children's National Health System, 111 Michigan Ave, NW, Washington, DC, 20010, USA. lherbert@childrensnational.org.
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Herbert
authors.affiliation: Center for Translational Science, Children's National Health System, 111 Michigan Ave, NW, Washington, DC, 20010, USA.|Department of Epidemiology & Biostatistics and Pediatrics, The George Washington University, Washington, DC, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Gillespie
authors.affiliation: Center for Translational Science, Children's National Health System, 111 Michigan Ave, NW, Washington, DC, 20010, USA.
authors.forename: Maureen
authors.initials: M
authors.lastname: Monaghan
authors.affiliation: Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Clarissa
authors.initials: C
authors.lastname: Holmes
authors.affiliation: Center for Translational Science, Children's National Health System, 111 Michigan Ave, NW, Washington, DC, 20010, USA.
authors.forename: Randi
authors.initials: R
authors.lastname: Streisand
mesh_terms: D000293:Adolescent; D002648:Child; D003922:Diabetes Mellitus, Type 1; D006801:Humans; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic
keywords: Randomized controlled trials; Recruitment; Retention; Type 1 diabetes