title: Is ischemia modified albumin a disease activity marker for inflammatory bowel diseases?
abstract: OBJECTIVE
  We aimed to identify ischemia-modified albumin (IMA) levels in inflammatory bowel disease (IBD) and IBD subgroups, and to examine its relation with disease activity index.
  
  
  METHODS
  Sixty-eight patients with IBD (35 ulcerative colitis [UC] and 33 crohn disease [CD]) and 65 healthy volunteers were included in the study. Rachmilewitz scoring system (endoscopic activity index [EAI]) was used to determine UC activity, and as for CD activity, CD activity index (CDAI) scoring was used. IMA measurement was performed with ELISA kit.
  
  
  RESULTS
  Ischemia-modified albumin levels in IBD, UC, and CD groups were comparably higher than the control group (37.7 ng/mL vs 42.4 ng/mL vs 36.4 ng/mL vs 21.8 ng/mL, respectively; P < 0.05). In IBD group, a positive correlation was identified between IMA level and CRP (r = 0.325, P = 0.011), EAI(r = 0.302, P = 0.020), and CDAI (r = 0.311, P = 0.013). In stepwise regression model; it was identified that IMA(OR = 1.496; P = 0.016) and CRP(OR = 3.457; P = 0.015) are predictors of IBD in comparison with the control group. In linear regression model, it was identified that risk factors such as log(IMA) and log(CRP) were independent predictors of log(CDAI) and log(EAI) levels.
  
  
  CONCLUSIONS
  This is the first study showing that IMA levels in IBD were determined higher in comparison with the control group. Moreover, IMA being a predictor for IBD and being positively correlated with disease activity indexes were determined for the first time in the study. In accordance with these results, it is possible to say that IMA in IBD might be related with the pathogenesis of disease and correlated with the severity of the disease.
authors.affiliation: Department of Gastroenterology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kaplan
authors.affiliation: Department of Gastroenterology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Yuksel
authors.affiliation: Department of Internal Medicine, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Ihsan
authors.initials: I
authors.lastname: Ates
authors.affiliation: Department of Gastroenterology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Zeki Mesut Yalın
authors.initials: ZM
authors.lastname: Kilic
authors.affiliation: Department of Microbiology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kilic
authors.affiliation: Department of Gastroenterology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Ufuk Barıs
authors.initials: UB
authors.lastname: Kuzu
authors.affiliation: Department of Gastroenterology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Kayacetin
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003093:Colitis, Ulcerative / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D003106:Colon / Q000473:pathology; D003113:Colonoscopy; D003424:Crohn Disease / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D012720:Severity of Illness Index; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human
keywords: ROS/RNS; chronic inflammation; crohn disease; oxidative stress; ulcerative colitis