title: Clinical Utility of Platelet Function Testing Following Non-Cardioembolic Stroke.
abstract: OBJECTIVE
  To verify the usefulness in selection of antiplatelet agent based on the platelet functional assays on the secondary prevention of ischemic stroke.
  
  
  METHODS
  Platelet functional assays were performed twice for acute ischemic stroke patients at hospitalization and 1 month after. An antiplatelet agent was administered based on the results of initial assay. The alterations of platelet aggregation by antiplatelet agent were evaluated in the second assay, and the patients were subsequently divided into inhibited and invariance groups. The relationship between incidence of recurrent ischemic or hemorrhagic stroke and the alterations of platelet aggregation by each selected antiplatelet agent was assessed.
  
  
  RESULTS
  Of the 585 consecutive patients, 124 were enrolled in the present study. Recurrent ischemic stroke was seen in 6 (5.3%) and 2 (18.2%) patients in the inhibited and invariance groups during the study period, respectively. In patients who were observed for more than 12 months, recurrent ischemic stroke was seen in 4 (5.0%) and 2 (33.3%) patients in the inhibited and invariance groups, respectively (p = 0.009).
  
  
  CONCLUSIONS
  We indicated that selection of the optimum antiplatelet agent based on the platelet functional assays for each individual patient may contribute to a reduction in the incidence of recurrence of ischemic stroke.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Uesugi
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Baba
authors.forename: Saori
authors.initials: S
authors.lastname: Kohara
authors.forename: Mie
authors.initials: M
authors.lastname: Shimizu
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizuma
authors.forename: Sachiko
authors.initials: S
authors.lastname: Yutani
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ohnuki
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Nagata
authors.affiliation: Division of Neurology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. shun@is.icc.u-tokai.ac.jp.
authors.forename: Shunya
authors.initials: S
authors.lastname: Takizawa
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D010979:Platelet Function Tests / Q000379:methods*; D012008:Recurrence; D055502:Secondary Prevention / Q000379:methods*; D020521:Stroke / Q000097:blood / Q000517:prevention & control*
chemical_list: D010975:Platelet Aggregation Inhibitors