title: NEVUS DEPIGMENTOSUS ASSOCIATED WITH NEVUS SPILUS: FIRST REPORT IN THE WORLD LITERATURE.
abstract: Nevus depigmentosus is a congenital, non-progressive, well-circumscribed hypopigmented macule, seen usually at birth, or within the first years of life. Its incidence is considered as rare, with prevalence from 0.4% to 3%. The etiopathogenesis in not fully understood, although a defect in the transfer of melanosomes from melanocytes to keratinocytes has been reported. In contrast, a sharply margined hyperpigmented macule of various sizes and shapes is known as Nevus spilus - the congenital type of a Becker's nevus. The association between nevus depigmentosus and nevus spilus is extremely rare, as the incidence, as well as the etiopathogenesis of this unilateral coexistence of such double presented pigmented disorder is unknown, due to the limited literature data reported as an example of twin spotting. We present an unusual case of nevus depigmentosus in association with nevus spilus. As far as our knowledge, this is the first report of such presentation in a young female patient. Various regiments are described as therapeutic options, such as PUVA, excimer laser, intensive pulsed light, Q-switched Alexandrite laser, Q-switched alexandrite laser and different grafting techniques, are reported as successful treatment of Nevus spilus, however not always effective in other Nevus depigmentosus.
authors.affiliation: "Onkoderma" - Ambulatory Clinic for Dermatology and Skin Surgery, Sofia, Bulgaria; Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany; Chair of Dermatology at University of Rome "G. Marconi", Rome, Italy; Internal Medicine Unit, Guastalla Hospital, Ausl Reggio, Emilia, Italy; Ambulatory Clinic for Dermatology and Venereology, University Hospital Lozenetz, Sofia, Bulgaria.
authors.forename: A
authors.initials: A
authors.lastname: Chokoeva
authors.affiliation: "Onkoderma" - Ambulatory Clinic for Dermatology and Skin Surgery, Sofia, Bulgaria; Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany; Chair of Dermatology at University of Rome "G. Marconi", Rome, Italy; Internal Medicine Unit, Guastalla Hospital, Ausl Reggio, Emilia, Italy; Ambulatory Clinic for Dermatology and Venereology, University Hospital Lozenetz, Sofia, Bulgaria.
authors.forename: U
authors.initials: U
authors.lastname: Wollina
authors.affiliation: "Onkoderma" - Ambulatory Clinic for Dermatology and Skin Surgery, Sofia, Bulgaria; Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany; Chair of Dermatology at University of Rome "G. Marconi", Rome, Italy; Internal Medicine Unit, Guastalla Hospital, Ausl Reggio, Emilia, Italy; Ambulatory Clinic for Dermatology and Venereology, University Hospital Lozenetz, Sofia, Bulgaria.
authors.forename: T
authors.initials: T
authors.lastname: Lotti
authors.affiliation: "Onkoderma" - Ambulatory Clinic for Dermatology and Skin Surgery, Sofia, Bulgaria; Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany; Chair of Dermatology at University of Rome "G. Marconi", Rome, Italy; Internal Medicine Unit, Guastalla Hospital, Ausl Reggio, Emilia, Italy; Ambulatory Clinic for Dermatology and Venereology, University Hospital Lozenetz, Sofia, Bulgaria.
authors.forename: C
authors.initials: C
authors.lastname: Tana
authors.affiliation: "Onkoderma" - Ambulatory Clinic for Dermatology and Skin Surgery, Sofia, Bulgaria; Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany; Chair of Dermatology at University of Rome "G. Marconi", Rome, Italy; Internal Medicine Unit, Guastalla Hospital, Ausl Reggio, Emilia, Italy; Ambulatory Clinic for Dermatology and Venereology, University Hospital Lozenetz, Sofia, Bulgaria.
authors.forename: G
authors.initials: G
authors.lastname: Tchernev
mesh_terms: D058070:Asymptomatic Diseases; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000473:pathology; D008544:Melanocytes / Q000473:pathology; D009508:Nevus, Pigmented / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D012878:Skin Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000473:pathology