title: dfcomb: An R-package for phase I/II trials of drug combinations.
abstract: In this paper, we present the dfcomb R package for the implementation of a single prospective clinical trial or simulation studies of phase I combination trials in oncology. The aim is to present the features of the package and to illustrate how to use it in practice though different examples. The use of combination clinical trials is growing, but the implementation of existing model-based methods is complex, so this package should promote the use of innovative adaptive designs for early phases combination trials.
authors.affiliation: INSERM, U1138, Equipe 22, Centre de Recherche des Cordeliers, Université Paris 5, Université Paris 6, Paris, France. Electronic address: marie-karelle.riviere@inserm.fr.
authors.forename: Marie-Karelle
authors.initials: MK
authors.lastname: Riviere
authors.affiliation: INRIA Paris-Rocquencourt, France.
authors.forename: Jacques-Henri
authors.initials: JH
authors.lastname: Jourdan
authors.affiliation: INSERM, U1138, Equipe 22, Centre de Recherche des Cordeliers, Université Paris 5, Université Paris 6, Paris, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Zohar
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D006801:Humans
keywords: Adaptive design; Combination; Dose-finding; Phase I; R package