title: Mining Gene Regulatory Networks by Neural Modeling of Expression Time-Series.
abstract: Discovering gene regulatory networks from data is one of the most studied topics in recent years. Neural networks can be successfully used to infer an underlying gene network by modeling expression profiles as times series. This work proposes a novel method based on a pool of neural networks for obtaining a gene regulatory network from a gene expression dataset. They are used for modeling each possible interaction between pairs of genes in the dataset, and a set of mining rules is applied to accurately detect the subjacent relations among genes. The results obtained on artificial and real datasets confirm the method effectiveness for discovering regulatory networks from a proper modeling of the temporal dynamics of gene expression profiles.
authors.forename: Mariano
authors.initials: M
authors.lastname: Rubiolo
authors.forename: Diego H
authors.initials: DH
authors.lastname: Milone
authors.forename: Georgina
authors.initials: G
authors.lastname: Stegmayer
mesh_terms: D000465:Algorithms; D000818:Animals; D057225:Data Mining / Q000379:methods*; D020869:Gene Expression Profiling / Q000379:methods*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D016571:Neural Networks, Computer; D010363:Pattern Recognition, Automated / Q000379:methods; D020543:Proteome / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D020543:Proteome