title: A new phenolic derivative with soluble epoxide hydrolase and nuclear factor-kappaB inhibitory activity from the aqueous extract of Acacia catechu.
abstract: One novel phenolic compound, (4S,5R)-4-(3,4-dihydroxyphenyl)-5-(3-oxobutyl)dihydrofuran-2(3H)-one (1), as well as 12 known compounds (2-13) was obtained from the aqueous extract of Acacia catechu and their chemical structures were determined by spectroscopic analysis. Compounds 8 and 9 exhibited significant soluble epoxide hydrolase (sEH) inhibitory activities with IC50 values of 26.6 ± 0.5 and 24.4 ± 5.6 μM, respectively. Compounds 7-10 showed significant inhibitory effects on TNFα-induced nuclear factor kappa B (NF-κB) transcriptional activity in a dose-dependent manner, with IC50 values ranging from 11.15 to 19.45 μM.
authors.affiliation: a College of Pharmacy , Chungnam National University , Daejeon , Korea.
authors.forename: Ya Nan
authors.initials: YN
authors.lastname: Sun
authors.affiliation: b School of Biotechnology , Yeungnam University , Gyeongsan , Korea.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: c Gyeongbuk Institute for Bio-industry (GIB) , Andong City , Korea.
authors.forename: Seok Bean
authors.initials: SB
authors.lastname: Song
authors.affiliation: d Shaanxi Key Laboratory of Natural Products & Chemical Biology , College of Science, Northwest A & F University , Yangling , China.
authors.forename: Xi Tao
authors.initials: XT
authors.lastname: Yan
authors.affiliation: a College of Pharmacy , Chungnam National University , Daejeon , Korea.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: a College of Pharmacy , Chungnam National University , Daejeon , Korea.
authors.forename: A Reum
authors.initials: AR
authors.lastname: Jo
authors.affiliation: a College of Pharmacy , Chungnam National University , Daejeon , Korea.
authors.forename: Jong Seong
authors.initials: JS
authors.lastname: Kang
authors.affiliation: a College of Pharmacy , Chungnam National University , Daejeon , Korea.
authors.forename: Kim
authors.initials: K
authors.lastname: Young Ho
mesh_terms: D000045:Acacia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002681:China; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: C000618913:(4S,5R)-4-(3,4-dihydroxyphenyl)-5-(3-oxobutyl)dihydrofuran-2(3H)-one; D000972:Antineoplastic Agents, Phytogenic; D004791:Enzyme Inhibitors; D016328:NF-kappa B; D010636:Phenols; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D004851:Epoxide Hydrolases
keywords: Acacia catechu; Leguminosae; NF-kappa B; soluble epoxide hydrolase (sEH)