title: ADAM Proteases and Gastrointestinal Function.
abstract: A disintegrin and metalloproteinases (ADAMs) are a family of cell surface proteases that regulate diverse cellular functions, including cell adhesion, migration, cellular signaling, and proteolysis. Proteolytically active ADAMs are responsible for ectodomain shedding of membrane-associated proteins. ADAMs rapidly modulate key cell signaling pathways in response to changes in the extracellular environment (e.g., inflammation) and play a central role in coordinating intercellular communication within the local microenvironment. ADAM10 and ADAM17 are the most studied members of the ADAM family in the gastrointestinal tract. ADAMs regulate many cellular processes associated with intestinal development, cell fate specification, and the maintenance of intestinal stem cell/progenitor populations. Several signaling pathway molecules that undergo ectodomain shedding by ADAMs [e.g., ligands and receptors from epidermal growth factor receptor (EGFR)/ErbB and tumor necrosis factor α (TNFα) receptor (TNFR) families] help drive and control intestinal inflammation and injury/repair responses. Dysregulation of these processes through aberrant ADAM expression or sustained ADAM activity is linked to chronic inflammation, inflammation-associated cancer, and tumorigenesis.
authors.affiliation: Cell Biology, Stem Cells, and Development Program and.|Division of Gastroenterology, Hepatology, and Nutrition and Department of Pediatrics, University of Colorado Medical School, Aurora, Colorado 80045; email: peter.dempsey@ucdenver.edu , jennifer.2.jones@ucdenver.edu , shelly.rustagi@childrenscolorado.org.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Jones
authors.affiliation: Division of Gastroenterology, Hepatology, and Nutrition and Department of Pediatrics, University of Colorado Medical School, Aurora, Colorado 80045; email: peter.dempsey@ucdenver.edu , jennifer.2.jones@ucdenver.edu , shelly.rustagi@childrenscolorado.org.
authors.forename: Shelly
authors.initials: S
authors.lastname: Rustagi
authors.affiliation: Cell Biology, Stem Cells, and Development Program and.|Division of Gastroenterology, Hepatology, and Nutrition and Department of Pediatrics, University of Colorado Medical School, Aurora, Colorado 80045; email: peter.dempsey@ucdenver.edu , jennifer.2.jones@ucdenver.edu , shelly.rustagi@childrenscolorado.org.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Dempsey
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism*; D000818:Animals; D041981:Gastrointestinal Tract / Q000378:metabolism* / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D008565:Membrane Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D008565:Membrane Proteins; D051722:ADAM Proteins
keywords: ADAM10; ADAM17; EGFR; Notch; TNFα; intestinal stem cells