title: Genome-wide association study reveals regions associated with gestation length in two pig populations.
abstract: Reproduction traits, such as gestation length (GLE), play an important role in dam line breeding in pigs. The objective of our study was to identify single nucleotide polymorphisms (SNPs) that are associated with GLE in two pig populations. Genotypes and deregressed breeding values were available for 2081 Dutch Landrace-based (DL) and 2301 Large White-based (LW) pigs. We identified two QTL regions for GLE, one in each population. For DL, three associated SNPs were detected in one QTL region spanning 0.52 Mbp on Sus scrofa chromosome (SSC) 2. For LW, four associated SNPs were detected in one region of 0.14 Mbp on SSC5. The region on SSC2 contains the heparin-binding EGF-like growth factor (HBEGF) gene, which promotes embryo implantation and has been described to be involved in embryo survival throughout gestation. The associated SNP can be used for marker-assisted selection in the studied populations, and further studies of the HBEGF gene are warranted to investigate its role in GLE.
authors.affiliation: Animal Breeding and Genomics Centre, Wageningen University, P.O. Box 338, 6700 AH, Wageningen, the Netherlands.|Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, 750 07, Uppsala, Sweden.
authors.forename: A M
authors.initials: AM
authors.lastname: Hidalgo
authors.affiliation: Animal Breeding and Genomics Centre, Wageningen University, P.O. Box 338, 6700 AH, Wageningen, the Netherlands.|Topigs Norsvin Research Center, P.O. Box 43, 6640 AA, Beuningen, the Netherlands.
authors.forename: M S
authors.initials: MS
authors.lastname: Lopes
authors.affiliation: Topigs Norsvin Research Center, P.O. Box 43, 6640 AA, Beuningen, the Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: Harlizius
authors.affiliation: Animal Breeding and Genomics Centre, Wageningen University, P.O. Box 338, 6700 AH, Wageningen, the Netherlands.
authors.forename: J W M
authors.identifier: http://orcid.org/0000-0002-6562-176X
authors.initials: JW
authors.lastname: Bastiaansen
mesh_terms: D000818:Animals; D001947:Breeding; D010064:Embryo Implantation / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D066257:Heparin-binding EGF-like Growth Factor / Q000235:genetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000235:genetics*; D040641:Quantitative Trait Loci; D013552:Swine / Q000235:genetics*
chemical_list: D066257:Heparin-binding EGF-like Growth Factor
keywords: HBEGF gene; length of pregnancy; quantitative trait loci; reproduction trait