title: Neuropsychological and Neuroanatomical Correlates of the Social Norms Questionnaire in Frontotemporal Dementia Versus Alzheimer's Disease.
abstract: Traditional neuropsychological batteries may not distinguish early behavioral variant frontotemporal dementia (bvFTD) from Alzheimer's disease (AD) without the inclusion of a social behavioral measure. We compared 33 participants, 15 bvFTD, and 18 matched patients with early-onset AD (eAD), on the Social Norms Questionnaire (SNQ), neuropsychological tests and 3-dimensional T1-weighted magnetic resonance imaging (MRI). The analyses included correlations of SNQ results (total score, overendorsement or "overadhere" errors, and violations or "break" errors) with neuropsychological results and tensor-based morphometry regions of interest. Patients with BvFTD had significantly lower SNQ total scores and higher overadhere errors than patients with eAD. On neuropsychological measures, the SNQ total scores correlated significantly with semantic knowledge and the overadhere subscores with executive dysfunction. On MRI analysis, the break subscores significantly correlated with lower volume of lateral anterior temporal lobes (aTL). The results also suggest that endorsement of social norm violations corresponds to the role of the right aTL in social semantic knowledge.
authors.affiliation: VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA Department of Neurology, Los Angeles, CA, USA hpanchal@g.ucla.edu.
authors.forename: Hemali
authors.initials: H
authors.lastname: Panchal
authors.affiliation: VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA Department of Neurology, Los Angeles, CA, USA Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, CA, USA Department of Psychiatry, Khon Kaen University, Khon Khaen, Thailand.
authors.forename: Pongsatorn
authors.initials: P
authors.lastname: Paholpak
authors.affiliation: Department of Psychology, School of Behavioral Health, Loma Linda, CA, USA.
authors.forename: Grace
authors.initials: G
authors.lastname: Lee
authors.affiliation: VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Carr
authors.affiliation: VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Barsuglia
authors.affiliation: VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA Department of Neurology, Los Angeles, CA, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Mather
authors.affiliation: VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA Department of Neurology, Los Angeles, CA, USA Department of Psychiatry & Biobehavioral Sciences, Los Angeles, CA, USA.
authors.forename: Elvira
authors.initials: E
authors.lastname: Jimenez
authors.affiliation: VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA Department of Neurology, Los Angeles, CA, USA Department of Psychiatry & Biobehavioral Sciences, Los Angeles, CA, USA.
authors.forename: Mario F
authors.initials: MF
authors.lastname: Mendez
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000473:pathology*; D057180:Frontotemporal Dementia / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D012660:Semantics; D066262:Social Norms; D011795:Surveys and Questionnaires; D013702:Temporal Lobe / Q000473:pathology
keywords: anterior temporal lobe Alzheimer’s disease; behavioral variant frontotemporal dementia; social norms; tensor-based morphometry