title: Increased beta rhythm as an indicator of inhibitory mechanisms in tourette syndrome.
abstract: BACKGROUND
  Inhibitory oscillatory mechanisms subserving tic compensation have been put forward in Tourette syndrome. Modulation of the beta rhythm (15-25 Hz) as the well-established oscillatory movement execution-inhibition indicator was tested during a cognitive-motor task in patients with Tourette syndrome.
  
  
  METHODS
  Performing a Go/NoGo task, 12 patients with Tourette syndrome and 12 matched controls were recorded using whole-head magnetoencephalography.
  
  
  RESULTS
  Compared to healthy participants, patients showed less beta suppression in the sensorimotor area and enhanced beta power in parieto-occipital brain regions contralaterally to the response hand. Average beta power and power gain correlated negatively with tic severity.
  
  
  CONCLUSIONS
  Increased motor inhibitory as well as visuomotor attentional processes are likely to subserve tic compensation. Correlational results suggest that stronger inhibitory compensation accompanies less tic severity.
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Düsseldorf University, Düsseldorf, Germany.
authors.forename: Valentina
authors.initials: V
authors.lastname: Niccolai
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Düsseldorf University, Düsseldorf, Germany.
authors.forename: Hanneke
authors.initials: H
authors.lastname: van Dijk
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Düsseldorf University, Düsseldorf, Germany.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Franzkowiak
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Düsseldorf University, Düsseldorf, Germany.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Finis
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Düsseldorf University, Düsseldorf, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Südmeyer
authors.affiliation: Department of Psychology, Hamburg University, Hamburg, Germany.
authors.forename: Melanie
authors.initials: M
authors.lastname: Jonas
authors.affiliation: Department of Neurology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
authors.forename: Götz
authors.initials: G
authors.lastname: Thomalla
authors.affiliation: Danish Research Center for Magnetic Resonance, Copenhagen University Hospital, Copenhagen, Denmark.|Department of Neurology, Copenhagen University Hospital Bispebjerg.
authors.forename: Hartwig Roman
authors.initials: HR
authors.lastname: Siebner
authors.affiliation: Clinic of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Müller-Vahl
authors.affiliation: Department of Pediatric and Adult Movement Disorders and Neuropsychiatry, University of Lübeck.
authors.forename: Alexander
authors.initials: A
authors.lastname: Münchau
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Düsseldorf University, Düsseldorf, Germany.
authors.forename: Alfons
authors.initials: A
authors.lastname: Schnitzler
authors.affiliation: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Düsseldorf University, Düsseldorf, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Biermann-Ruben
mesh_terms: D000328:Adult; D001611:Beta Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D005879:Tourette Syndrome / Q000503:physiopathology*
keywords: Tourette syndrome; attention; beta; inhibition; oscillations