title: Stability of underdominant genetic polymorphisms in population networks.
abstract: Heterozygote disadvantage is potentially a potent driver of population genetic divergence. Also referred to as underdominance, this phenomena describes a situation where a genetic heterozygote has a lower overall fitness than either homozygote. Attention so far has mostly been given to underdominance within a single population and the maintenance of genetic differences between two populations exchanging migrants. Here we explore the dynamics of an underdominant system in a network of multiple discrete, yet interconnected, populations. Stability of genetic differences in response to increases in migration in various topological networks is assessed. The network topology can have a dominant and occasionally non-intuitive influence on the genetic stability of the system.
authors.affiliation: Department of Biology, University of Hawai'i at Mānoa, Honolulu, Hawai'i 96822, United States.
authors.forename: Áki J
authors.initials: ÁJ
authors.lastname: Láruson
authors.affiliation: Department of Biology, University of Hawai'i at Mānoa, Honolulu, Hawai'i 96822, United States. Electronic address: floydr@hawaii.edu.
authors.forename: Floyd A
authors.initials: FA
authors.lastname: Reed
mesh_terms: D000465:Algorithms; D000483:Alleles; D000818:Animals; D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D051456:Gene Flow / Q000235:genetics; D005787:Gene Frequency; D056084:Genetic Fitness / Q000235:genetics*; D005828:Genetics, Population / Q000379:methods; D006579:Heterozygote; D006801:Humans; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D012641:Selection, Genetic / Q000235:genetics
keywords: Coordination game; Dynamical system; Network topology; Population genetics; Underdominance