title: Regulatory Roles of miRNAs in Aging.
abstract: Aging is a biological process characterized by the progressive deterioration of physiological functions that occurs through the accumulation of macromolecular and cellular damage. This phenomenon impairs tissue function and is a risk factor for many disorders including cardiovascular disease, neurodegenerative disorders, and cancer. A recent study has enumerated nine cellular and molecular hallmarks that represent common denominators of aging and together determine the aging phenotype, highlighting the concept of aging plasticity. Among the multiple molecular mechanisms which may contribute to aging modulation, microRNAs (miRNAs) are raising enormous interest due to their ability to affect all the "Hallmarks of Aging." In this chapter, we will focus on the description of the diverse functional roles of geromiRs, the large and growing subgroup of miRNAs implicated in aging. We will also address the molecular mechanisms underlying miRNA function in aging and discuss potential strategies for managing aging and extending longevity based on geromiR modulation.
authors.affiliation: Department of Molecular Biochemistry and Biology, University of Oveido, University Institute of Oncology, Oviedo, 33006, Spain.
authors.forename: Xurde M
authors.initials: XM
authors.lastname: Caravia
authors.affiliation: Department of Molecular Biochemistry and Biology, University of Oveido, University Institute of Oncology, Oviedo, 33006, Spain. clo@uniovi.es.
authors.forename: Carlos
authors.initials: C
authors.lastname: López-Otín
mesh_terms: D000375:Aging; D000818:Animals; D016922:Cellular Senescence; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D042822:Genomic Instability; D006801:Humans; D008136:Longevity; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
chemical_list: D035683:MicroRNAs
keywords: Aging; Life-span; Longevity; Senescence; geromiRs