title: Swelling of poly(N-isopropylacrylamide) P(NIPA)-based hydrogels with bacterial-synthesized prodigiosin for localized cancer drug delivery.
abstract: We present the results of swelling experiments on poly(N-isopropylacrylamide) P(NIPA)-based hydrogels. The swelling characteristics of P(NIPA)-based homo-polymer and P(NIPA)-based co-polymers with Acrylamide (AM) and Butyl Methacrylate (BMA), were studied using weight gain experiments. The swelling due to the uptake of biosynthesized cancer drug, prodigiosin (PG), was compared to swelling in controlled environments (distilled water (DW), paclitaxel™ (PT) and bromophenol blue (BB)). PG was synthesized with Serratia marcescens (SM) subsp. marcescens bacteria. The mechanisms of drug diffusion and swelling of P(NIPA)-based hydrogels are also elucidated along with characterizing the heterogeneous porous structure of the P(NIPA)-based hydrogels. High Performance Liquefied Chromatography (HPLC) analysis revealed the purity of the biosynthesized prodigiosin to be 92.8%. PG was then absorbed by P(NIPA)-based hydrogels at temperatures between 28-48°C. This is a temperature range that might be encountered during the implantation of biomedical devices for localized cancer treatment via drug delivery and hyperthermia. The results obtained are shown to provide insights for the design of implantable biomedical devices for the localized treatment of breast cancer.
authors.affiliation: Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria; Department of Materials Science and Engineering, Kwara State University, Malete, Nigeria.
authors.forename: Y
authors.initials: Y
authors.lastname: Danyuo
authors.affiliation: Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria; Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex (SHESTCO), Abuja, Federal Capital Territory, Nigeria.
authors.forename: S
authors.initials: S
authors.lastname: Dozie-Nwachukwu
authors.affiliation: Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria; Department of Materials Science and Engineering, Kwara State University, Malete, Nigeria; Department of Mechanical and Aerospace Engineering, 1 Olden Street, Princeton, NJ 08544, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Obayemi
authors.affiliation: Department of Theoretical Physics, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria; Department of Physics, Salem University, Lokoja-Ajaokuta Road, Kogi, Nigeria.
authors.forename: C J
authors.initials: CJ
authors.lastname: Ani
authors.affiliation: Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria; Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex (SHESTCO), Abuja, Federal Capital Territory, Nigeria.
authors.forename: O S
authors.initials: OS
authors.lastname: Odusanya
authors.affiliation: Department of Mechanical and Aerospace Engineering, 1 Olden Street, Princeton, NJ 08544, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Oni
authors.affiliation: Department of Chemistry, Bronx Community College, New York, NY, USA; Princeton Institute for the Science and Technology of Materials (PRISM), 70 Prospect Street, Princeton, NJ 08544, USA.
authors.forename: N
authors.initials: N
authors.lastname: Anuku
authors.affiliation: Department of Mechanical and Aerospace Engineering, 1 Olden Street, Princeton, NJ 08544, USA.
authors.forename: K
authors.initials: K
authors.lastname: Malatesta
authors.affiliation: Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria; Department of Mechanical and Aerospace Engineering, 1 Olden Street, Princeton, NJ 08544, USA; Princeton Institute for the Science and Technology of Materials (PRISM), 70 Prospect Street, Princeton, NJ 08544, USA. Electronic address: soboyejo@princeton.edu.
authors.forename: W O
authors.initials: WO
authors.lastname: Soboyejo
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D004343:Drug Implants / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006801:Humans; D020100:Hydrogels / Q000494:pharmacology; D011353:Prodigiosin / Q000737:chemistry / Q000494:pharmacology; D012706:Serratia marcescens / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; D004337:Drug Carriers; D004343:Drug Implants; D020100:Hydrogels; C052970:poly-N-isopropylacrylamide; D011353:Prodigiosin
keywords: P(NIPA)-based hydrogels;; Phase transition temperature; Prodigiosin;; Serratia marcescens;; Swelling kinetics;