title: From insertion to multicomponent coupling: temperature dependent reactions of arynes with aliphatic alcohols.
abstract: The temperature dependent selectivity switch in the reaction of arynes with aliphatic alcohols in THF has been reported. At -20 °C, arynes smoothly insert into the O-H bond of alcohols to form alkyl aryl ethers. Interestingly, at 60 °C, a highly selective multicomponent coupling occurs with the solvent THF acting as the nucleophilic trigger affording (4-(alkoxy)butoxy)arenes.
authors.affiliation: Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune-411008, India. at.biju@ncl.res.in.
authors.forename: Manikandan
authors.initials: M
authors.lastname: Thangaraj
authors.forename: Sachin Suresh
authors.initials: SS
authors.lastname: Bhojgude
authors.forename: Manoj V
authors.initials: MV
authors.lastname: Mane
authors.forename: Akkattu T
authors.initials: AT
authors.lastname: Biju