title: The Relationship Between Lipoprotein-Associated Phospholipase A(2), Cholesteryl Ester Transfer Protein and Lipid Profile and Risk of Atherosclerosis in Women with Iron Deficiency Anaemia.
abstract: BACKGROUND
  The relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2), cholesteryl ester transfer protein (CETP), and risk of atherosclerosis in IDA women has not been fully clarified. The objective of this study was to investigate lipid-related atherogenic risk factors in women with IDA.
  
  
  METHODS
  Eighty women with IDA and 80 age-matched healthy women as the control group were enrolled in the study. Serum lipid profile, Lp-PLA2, and CETP were determined. Correlations between lipid-related atherogenic risk factors were analyzed by Pearson's correlation analyses.
  
  
  RESULTS
  TG levels were higher and HDL-C levels were lower in the IDA women. Lp-PLA2 activity, Lp-PLA2 concentration, and CETP concentration were higher in the IDA women. There were negative correlations between activity or concentration of Lp-PLA2 and hemoglobin level (r = -0.29 or r = -0.33, p < 0.05), as well as HDL-C level (r = -0.38 or r = -0.35, p < 0.05). Positive correlations were observed between Lp-PLA2 activity and Lp-PLA2 concentration and low-density lipoprotein cholesterol (LDL-C) level (r = 0.41 or r = 0.36 respectively, p < 0.05). CETP concentration was negatively correlated with hemoglobin (r = -0.56, p < 0.01) and HDL-C level (r = -0.35, p < 0.05) and positively correlated with triglyceride level (r = 0.34, p < 0.05).
  
  
  CONCLUSIONS
  Increases in the levels of circulating CETP and Lp-PLA2 might partly play a role in the atherogenic disturbances in patients with IDA through increased susceptibility to lipid peroxidation.
authors.forename: Shuang
authors.initials: S
authors.lastname: Yang
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Chen
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Xu
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood* / Q000150:complications; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications; D001772:Blood Cell Count; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008055:Lipids; D014280:Triglycerides; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase