title: Endoscopic Disease Activity in Inflammatory Bowel Disease.
abstract: Endoscopic scoring systems in Crohn's disease and ulcerative colitis aim to translate the assessment of mucosal disease activity into a quantified value. This value seeks to provide a clear, objective record of the endoscopic mucosal severity, which can then be used to guide medical management decisions. The primary driver of all endoscopic indices, however, is to define a scale of responsiveness for therapeutic endpoints in clinical trials. Mucosal healing now has widespread acceptance as a therapeutic and clinical endpoint, but despite the development of multiple endoscopic scoring systems, the endoscopic definition has yet to be resolved. This review describes recent advances in endoscopic scoring systems for ulcerative colitis (Mayo Clinic endoscopy subscore, UCEIS, and UCCIS among others) and for Crohn's disease.
authors.affiliation: Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK.
authors.forename: Shara Nguyen
authors.initials: SN
authors.lastname: Ket
authors.affiliation: Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Palmer
authors.affiliation: Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK. simon.travis@ndm.ox.ac.uk.|Translational Gastroenterology Unit, Experimental Medicine Division, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK. simon.travis@ndm.ox.ac.uk.
authors.forename: Simon
authors.initials: S
authors.lastname: Travis
mesh_terms: D003093:Colitis, Ulcerative / Q000175:diagnosis; D003424:Crohn Disease / Q000175:diagnosis; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis*; D015588:Observer Variation; D012720:Severity of Illness Index
keywords: Crohn’s disease; Endoscopy; Mayo score; UCEIS; Ulcerative colitis