title: Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside.
abstract: Recent advances in basic cardiovascular research as well as their translation into the clinical situation were the focus at the last "New Frontiers in Cardiovascular Research meeting". Major topics included the characterization of new targets and procedures in cardioprotection, deciphering new players and inflammatory mechanisms in ischemic heart disease as well as uncovering microRNAs and other biomarkers as versatile and possibly causal factors in cardiovascular pathogenesis. Although a number of pathological situations such as ischemia-reperfusion injury or atherosclerosis can be simulated and manipulated in diverse animal models, also to challenge new drugs for intervention, patient studies are the ultimate litmus test to obtain unequivocal information about the validity of biomedical concepts and their application in the clinics. Thus, the open and bidirectional exchange between bench and bedside is crucial to advance the field of ischemic heart disease with a particular emphasis of understanding long-lasting approaches in cardioprotection.
authors.affiliation: Institute of Biochemistry, Medical School, Justus-Liebig University, Giessen, Germany.|Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore, Singapore.|National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.|Department of Microbiology, Kazan Federal University, Kazan, Russian Federation.|Escuela de Ingeniería y Ciencias, Centro de Biotecnología-FEMSA, Tecnológico de Monterrey, Monterrey, NL, México.
authors.forename: Hector A
authors.initials: HA
authors.lastname: Cabrera-Fuentes
authors.affiliation: Institute of Genetics, Univeristy of the Sea. Puerto Escondido Campus, Oaxaca Oaxacan System of State Universities (SUNEO), Oaxaca, México.
authors.forename: Corina
authors.initials: C
authors.lastname: Alba-Alba
authors.affiliation: Research Unit, Hospital of Santa Cristina, Research Institute Princesa (IP), Autonomous University of Madrid, Madrid, Spain.
authors.forename: Julian
authors.initials: J
authors.lastname: Aragones
authors.affiliation: Institute of Biochemistry and Molecular Cell Biology, RWTH Aachen University, Aachen, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Bernhagen
authors.affiliation: Department of Microbiology, Kazan Federal University, Kazan, Russian Federation.|Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
authors.forename: William A
authors.initials: WA
authors.lastname: Boisvert
authors.affiliation: Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus N, Denmark.
authors.forename: Hans E
authors.initials: HE
authors.lastname: Bøtker
authors.affiliation: Department of Hematology, Instituto Nacional de Cancerología, Mexico City, Mexico.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Cesarman-Maus
authors.affiliation: Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, Frankfurt, Germany.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Fleming
authors.affiliation: Valld'Hebron University Hospital and Research Institute, Barcelona, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Garcia-Dorado
authors.affiliation: Hatter Institute and MRC Inter-University Cape Heart Unit, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Lecour
authors.affiliation: Institute for Molecular Cardiovascular Research, RWTH University Hospital Aachen, Aachen, Germany.
authors.forename: Elisa
authors.initials: E
authors.lastname: Liehn
authors.affiliation: Department of Cardiology, The Rayne Institute, St Thomas' Campus, King's College London, London, UK.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Marber
authors.affiliation: Department of Clinical Pharmacology, University College London, London, UK.
authors.forename: Nephtali
authors.initials: N
authors.lastname: Marina
authors.affiliation: The James Black Centre, King's College, University of London, London, UK.
authors.forename: Manuel
authors.initials: M
authors.lastname: Mayr
authors.affiliation: Department of Molecular Biology, National Institute of Cardiology, Mexico City, Mexico.
authors.forename: Oscar
authors.initials: O
authors.lastname: Perez-Mendez
authors.affiliation: Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Miura
authors.affiliation: Valld'Hebron University Hospital and Research Institute, Barcelona, Spain.
authors.forename: Marisol
authors.initials: M
authors.lastname: Ruiz-Meana
authors.affiliation: Laboratorio de Biofísica Cardiaca, Instituto de Fisiología, Universidad Autónoma de Puebla, Puebla, Mexico.
authors.forename: Eduardo M
authors.initials: EM
authors.lastname: Salinas-Estefanon
authors.affiliation: Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore, Singapore.|National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.
authors.forename: Sang-Bing
authors.initials: SB
authors.lastname: Ong
authors.affiliation: Institute of Anatomy and Vascular Biology, Westfalian-Wilhelms-University, Münster, Germany.
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Schnittler
authors.affiliation: Laboratory of Parasitology, Department of Microbiology and Parasitology, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico.
authors.forename: Jose T
authors.initials: JT
authors.lastname: Sanchez-Vega
authors.affiliation: Laboratorio Multidisciplinario de Ciencias Biomédicas, Instituto de Investigaciones Medico-Biológicas, Universidad Veracruzana campus Veracruz, Veracruz, Mexico.
authors.forename: Adriana
authors.initials: A
authors.lastname: Sumoza-Toledo
authors.affiliation: Department of Pathology, John A. Burns School of Medicine, University of Hawaii, Honolulu, USA.
authors.forename: Carl-Wilhelm
authors.initials: CW
authors.lastname: Vogel
authors.affiliation: Department of Microbiology, Kazan Federal University, Kazan, Russian Federation.
authors.forename: Dina
authors.initials: D
authors.lastname: Yarullina
authors.affiliation: The Hatter Cardiovascular Institute, University College London, London, UK.|The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK.
authors.forename: Derek M
authors.initials: DM
authors.lastname: Yellon
authors.affiliation: Institute of Biochemistry, Medical School, Justus-Liebig University, Giessen, Germany.
authors.forename: Klaus T
authors.initials: KT
authors.lastname: Preissner
authors.affiliation: Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore, Singapore. derek.hausenloy@duke-nus.edu.sg.|National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore. derek.hausenloy@duke-nus.edu.sg.|The Hatter Cardiovascular Institute, University College London, London, UK. derek.hausenloy@duke-nus.edu.sg.|The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK. derek.hausenloy@duke-nus.edu.sg.
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Hausenloy
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases; D006801:Humans; D057170:Translational Research, Biomedical
keywords: Atherosclerosis; Cardioprotection; Cardiovascular disease; Endothelial permeability; Extracellular RNA; High-density lipoprotein; Hypoxia; Inflammation; Ischemia/reperfusion injury; Macrophage polarization; MicroRNAs; Mitochondria; Platelet dysfunction; Vascular biology