title: [DRUG-INDUCED LUPUS CAUSED BY LONG TERM MINOCYCLINE TREATMENT FOR ACNE VULGARIS].
abstract: An 18-year-old Japanese girl had received oral minocycline 200mg daily for treatment of acne vulgaris since 16 years old. She had a fever three months before admission, followed by joint pains in her knees, elbows and several proximal interphalangeal joints one month before admission. She was referred to our hospital because of a high serum level of anti-DNA antibody. She had already discontinued oral minocycline five weeks before admission, because she missed her medication refilled. On admission, the arthralgia and fever spontaneously resolved, and there were no laboratory evidence of hypocomplementemia and cytopenia. She had neither erythema nor internal organ involvements. Because her symptoms subsided spontaneously after the cessation of minocycline, she was considered to have drug-induced lupus. Both the arthralgia and fever did not relapse, and anti-ds DNA antibody returned to normal during a follow-up period without treatment. There are few reports of drug-induced lupus caused by minocycline in Japan. This case highlights the importance of considering minocycline-induced lupus.
authors.affiliation: Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University.
authors.forename: Shunichiro
authors.initials: S
authors.lastname: Hanai
authors.forename: Takeo
authors.initials: T
authors.lastname: Sato
authors.forename: Koichi
authors.initials: K
authors.lastname: Takeda
authors.forename: Katsuya
authors.initials: K
authors.lastname: Nagatani
authors.forename: Masahiro
authors.initials: M
authors.lastname: Iwamoto
authors.forename: Seiji
authors.initials: S
authors.lastname: Minota
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000974:Antibodies, Antinuclear / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000175:diagnosis; D008911:Minocycline / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000974:Antibodies, Antinuclear; D015415:Biomarkers; D008911:Minocycline