title: High prevalence of cardiovascular comorbidities in patients with rheumatoid arthritis from a population-based cross-sectional study of a Japanese health insurance database.
abstract: OBJECTIVE
  To reveal any association between rheumatoid arthritis (RA) and cardiovascular comorbidities using a Japanese health insurance database.
  
  
  METHODS
  This population-based cross-sectional study was conducted using health insurance data provided by the Japan Medical Data Center Co., Ltd. We identified 2762 RA subjects having RA diagnostic codes (ICD10 codes; M05, M060, M062-63, M068-069) with at least two physician visits more than two months apart between June 2011 and May 2012 (RA group, n = 2762). We selected age- (±5 years), sex-, and study period-matched non-RA subjects (non-RA group, n = 27,620). We compared the prevalence of cardiovascular and related comorbidities (ischemic heart diseases [IHD], cerebral infarction, hypertension [HT], dyslipidemia [DL], and diabetes mellitus [DM]) between these groups and investigated the association between RA and cardiovascular comorbidities using a conditional logistic regression analysis.
  
  
  RESULTS
  The prevalence of all the investigated comorbidities in the RA group was significantly higher compared to the non-RA group. Odds ratios [95% confidence interval] of RA for IHD and cerebral infarction were 2.0 [1.5-2.5] and 3.1 [2.2-4.2] respectively, after adjusting for HT, DL, and DM.
  
  
  CONCLUSIONS
  This study revealed for the first time in the Japanese population that RA was significantly associated with cardiovascular comorbidities.
authors.affiliation: a Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .|b Department of Rheumatology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .
authors.forename: Ryoko
authors.initials: R
authors.lastname: Sakai
authors.affiliation: a Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .|b Department of Rheumatology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .
authors.forename: Fumio
authors.initials: F
authors.lastname: Hirano
authors.affiliation: a Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .|b Department of Rheumatology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .
authors.forename: Mari
authors.initials: M
authors.lastname: Kihara
authors.affiliation: a Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .|b Department of Rheumatology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .
authors.forename: Waka
authors.initials: W
authors.lastname: Yokoyama
authors.affiliation: a Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .|b Department of Rheumatology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .
authors.forename: Hayato
authors.initials: H
authors.lastname: Yamazaki
authors.affiliation: a Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .|b Department of Rheumatology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .
authors.forename: Sayoko
authors.initials: S
authors.lastname: Harada
authors.affiliation: a Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .|b Department of Rheumatology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nanki
authors.affiliation: a Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .|b Department of Rheumatology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .|c Clinical Research Center , Tokyo Medical and Dental University Hospital of Medicine , Tokyo , Japan , and.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Koike
authors.affiliation: d Tokyo Medical and Dental University , Tokyo , Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Miyasaka
authors.affiliation: a Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .|b Department of Rheumatology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan .
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Harigai
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000453:epidemiology*; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D016208:Databases, Factual; D003920:Diabetes Mellitus / Q000453:epidemiology*; D050171:Dyslipidemias / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007348:Insurance, Health; D007564:Japan; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012107:Research Design; D012307:Risk Factors
keywords: Comorbidity; Epidemiology; Prevalence; Rheumatoid arthritis