title: Spray-dried powders improve the controlled release of antifungal tioconazole-loaded polymeric nanocapsules compared to with lyophilized products.
abstract: This work aimed to obtain solid formulations from polymeric nanocapsules and nanoemulsions containing tioconazole, a broad spectrum antifungal drug. Two dehydration methods were used: spray-drying and freeze drying, using lactose as adjuvant (10%, w/v). The liquid formulations had a mean particle size around 206 nm and 182 nm for nanocapsules and nanoemulsions, respectively, and an adequate polydispersity index. Tioconazole content was close to the theoretical amount (1.0 mg/mL). After drying, the content ranged between 98 and 102%with a mean nanometric size of the dried products after redispersion. Scanning electron microscopy showed that the particles are rounded, sphere-shaped for the dried products obtained by spray-drying, and shapeless and irregular shapes for those obtained by freeze-drying. In the microbiological evaluation, all dried products remained active against the yeast Candida albicans when compared to the original systems. The dried products obtained by spray-drying from nanocapsules presented better control of the tioconazole release when compared to the freeze-drying products.
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Av. Roraima, 1000, Santa Maria, RS, 97105-900, Brazil.
authors.forename: Roseane Fagundes
authors.initials: RF
authors.lastname: Ribeiro
authors.affiliation: Curso de Farmácia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Av. Roraima, 1000, Santa Maria, RS, 97105-900, Brazil.
authors.forename: Mariana Heldt
authors.initials: MH
authors.lastname: Motta
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Av. Roraima, 1000, Santa Maria, RS, 97105-900, Brazil.
authors.forename: Andréia Pisching Garcia
authors.initials: APG
authors.lastname: Härter
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Av. Roraima, 1000, Santa Maria, RS, 97105-900, Brazil.
authors.forename: Fernanda Cramer
authors.initials: FC
authors.lastname: Flores
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, Porto Alegre, RS, 90610-000, Brazil.
authors.forename: Ruy Carlos Ruver
authors.initials: RCR
authors.lastname: Beck
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Av. Roraima, 1000, Santa Maria, RS, 97105-900, Brazil.
authors.forename: Scheila Rezende
authors.initials: SR
authors.lastname: Schaffazick
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Av. Roraima, 1000, Santa Maria, RS, 97105-900, Brazil. Electronic address: csbona@smail.ufsm.br.
authors.forename: Cristiane
authors.initials: C
authors.lastname: de Bona da Silva
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry*; D004355:Drug Stability; D005612:Freeze Drying; D007093:Imidazoles / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011208:Powders / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D053769:Nanocapsules; D011108:Polymers; D011208:Powders; C020527:tioconazole
keywords: Dried products; Freeze-drying; Nanocapsules; Spray-drying; Tioconazole