title: Muscle damage, metabolism, and oxidative stress in mdx mice: Impact of aerobic running.
abstract: We tested how a treadmill exercise program influences oxygen consumption, oxidative stress, and exercise capacity in the mdx mouse, a model of Duchenne muscular dystrophy.
  
  
  
  At age 4 weeks mdx mice were subjected to 4 weeks of twice-weekly treadmill exercise. Sedentary mdx and wild-type mice served as controls. Oxygen consumption, time to exhaustion, oxidative stress, and myofiber damage were assessed.
  
  
  
  At age 4 weeks, there was a significant difference in exercise capacity between mdx and wild-type mice. After exercise, mdx mice had lower basal oxygen consumption and exercise capacity, but similar maximal oxygen consumption. Skeletal muscle from these mice displayed increased oxidative stress. Collagen deposition was higher in exercised versus sedentary mice.
  
  
  
  Exercised mdx mice exhibit increased oxidative stress, as well as deficits in exercise capacity, baseline oxygen consumption, and increased myofiber fibrosis. Muscle Nerve 54: 110-117, 2016.
authors.affiliation: Department of Human Sciences, Kinesiology Program, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Schill
authors.affiliation: Department of Human Sciences, Kinesiology Program, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Alex R
authors.initials: AR
authors.lastname: Altenberger
authors.affiliation: Department of Molecular & Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Jeovanna
authors.initials: J
authors.lastname: Lowe
authors.affiliation: Department of Physiology & Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Muthu
authors.initials: M
authors.lastname: Periasamy
authors.affiliation: Deparment of Pharmacology, College of Medicine, The Ohio State University, Columbus, Ohio.
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Villamena
authors.affiliation: Department of Molecular & Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
authors.forename: JIll A
authors.initials: JA
authors.lastname: Rafael-Fortney
authors.affiliation: Department of Human Sciences, Kinesiology Program, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Steven T
authors.initials: ST
authors.lastname: Devor
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism; D004195:Disease Models, Animal; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D005978:Glutathione / Q000378:metabolism; D019803:Glutathione Disulfide / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018101:Mice, Inbred mdx; D020388:Muscular Dystrophy, Duchenne / Q000235:genetics / Q000534:rehabilitation*; D009210:Myofibrils / Q000378:metabolism* / Q000473:pathology*; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology*; D010101:Oxygen Consumption / Q000235:genetics / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000379:methods*
chemical_list: D003094:Collagen; D005978:Glutathione; D006909:Hydroxyproline; D019803:Glutathione Disulfide
keywords: DMD; MDX; exercise; oxidative stress; oxygen consumption; treadmill