title: Optimising element choice for nanoparticle radiosensitisers.
abstract: There is considerable interest in the use of heavy atom nanoparticles as theranostic contrast agents due to their high radiation cross-section compared to soft tissue. However, published studies have primarily focused on applications of gold nanoparticles. This study applies Monte Carlo radiation transport modelling using Geant4 to evaluate the macro- and micro-scale radiation dose enhancement following X-ray irradiation with both imaging and therapeutic energies on nanoparticles consisting of stable elements heavier than silicon. An approach based on the Local Effect Model was also used to assess potential biological impacts. While macroscopic dose enhancement is well predicted by simple absorption cross-sections, nanoscale dose deposition has a much more complex dependency on atomic number, with local maxima around germanium (Z = 32) and gadolinium (Z = 64), driven by variations in secondary Auger electron spectra, which translate into significant variations in biological effectiveness. These differences may provide a valuable tool for predicting and elucidating fundamental mechanisms of these agents as they move towards clinical application.
authors.affiliation: Department of Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA and Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK. stephen.mcmahon@qub.ac.uk.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: McMahon
authors.affiliation: Department of Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.
authors.forename: Harald
authors.initials: H
authors.lastname: Paganetti
authors.affiliation: Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK. stephen.mcmahon@qub.ac.uk.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Prise
mesh_terms: D000818:Animals; D005682:Gadolinium / Q000737:chemistry / Q000627:therapeutic use; D005857:Germanium / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D008956:Models, Chemical; D011838:Radiation-Sensitizing Agents / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D011838:Radiation-Sensitizing Agents; D005857:Germanium; D005682:Gadolinium