title: [Analysis of correlated factors of cervical lymphatic metastasis of T3 and T4 glottic carcinoma].
abstract: OBJECTIVE
  To analyze the correlated factors of cervical lymphatic metastasis of T3 and T4 glottic carcinoma.
  
  
  METHODS
  We did a retrospective analysis of 91 glottic carcinoma patients' clinical data to analyze cervical lymph node metastasis on different T stage, pathologic degree and the tumor sites.
  
  
  RESULTS
  The cervical lymph node metastasis rate of 91 cases of T3 and T4 glottic carcinoma was 21.98%. T3 group's metastasis rate was 18.06% (13/72), T4 group's metastasis rate was 36.84% (7/19), P > 0.05. Grouped according to the degree of pathological differentiation, well-differentiated squamous cell carcinoma metastasis rate is 13.89% (5/36), middle-differentiated squamous cell carcinoma metastasis rate is 26.00% (13/50), and poorly-differentiated squamous cell carcinoma metastasis rate is 40.00% (2/5), P > 0.05. Cervical lymph node metastasis rate was 16.22%, when the tumor invading supraglottic region. Cervical lymph node metastasis rate was 15.38%, when the tumor invading subraglottic region. Cervical lymph node metastasis rate was 46.15%, when the tumor invading supraglottic and subraglottic region (P < 0.01).
  
  
  CONCLUSIONS
  Cervical lymph node metastasis in cN0 patient with supraglottic carcinoma is effected by T classification, cervical lymphatic metastasis of T3 and T4 glottic carcinoma is not entirely effected by T stage and pathologic degree. When the tumor invades supraglottic and subraglottic region, cervical lymph node metastasis is significantly higher. Therefore, the area of tumor invasion is an important factor for lymph node metastasis.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Li
authors.forename: Jixuan
authors.initials: J
authors.lastname: Wang
authors.forename: Haiyan
authors.initials: H
authors.lastname: Sun
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Hu
authors.forename: Donghai
authors.initials: D
authors.lastname: Wang
authors.forename: Guofeng
authors.initials: G
authors.lastname: Zhao
mesh_terms: D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D042601:Lymphatic Vessels; D009333:Neck; D037981:Neck Dissection; D009367:Neoplasm Staging; D012189:Retrospective Studies