title: [The Concept of Immunogenic Cell Death in Antitumor Immunity].
abstract: Cancer cell death can be immunogenic or nonimmunogenic depending on the initiating stimulus. The immunogenic characteristics of immunogenic cell death are mainly mediated by damage-associated molecular patterns represented by preapoptotic exposure of calreticulin and heat shock proteins (HSP70 and HSP90) from endoplasmic reticulum at the cell surface and active secretion of adenosintriphospate. Other damage-associated molecular patterns are produced in late stage apoptosis as high mobility group box 1 protein (HMGB1) into the extracellular milieu. Such signals operate on various receptors expressed by antigen presenting cells, mainly by population of dendritic cells, to stimulate the activation of antigen specific T-cell response. In this review, we describe the current known immunogenic cell death inducers and their potential to activate antitumor immune response.
authors.forename: J
authors.initials: J
authors.lastname: Fučíková
authors.forename: J
authors.initials: J
authors.lastname: Bartůňková
authors.forename: R
authors.initials: R
authors.lastname: Špíšek
mesh_terms: D017209:Apoptosis; D003713:Dendritic Cells / Q000276:immunology; D024243:HMGB1 Protein / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D024243:HMGB1 Protein