title: Association between circulating CCL2 levels and modifiable behaviors in overweight and obese adolescents: a cross-sectional pilot study.
abstract: BACKGROUND
  We evaluated the relationship between an early inflammatory biomarker, chemokine (C-C motif) ligand 2 (CCL2), and other clinical biomarkers and lifestyle behaviors, in overweight/obese adolescents at high risk of developing cardiometabolic derangements.
  
  
  METHODS
  We collected anthropometric measurements, clinical biomarkers, and three 24-h dietary recalls from 21 vocational high school students (91% male), 14-19 years, with body mass index (BMI) ≥25 kg/m2. Pearson's or Spearman's correlation coefficients were used to examine relationships.
  
  
  RESULTS
  Mean BMI was 33.2 kg/m2 (range 25.7-45.6) and 38% were prediabetic by fasting glucose. Mean CCL2 was 512.9 pg/mL (range 220-917) and positively correlated with triglycerides (r=0.45; p=0.04) and TNF-α (r=0.57; p=0.007) and marginally negatively correlated with fruit/vegetable intake (r=-0.42, p=0.06) and omega-3 fatty acids (r=-0.41, p=0.07).
  
  
  CONCLUSIONS
  CCL2 was positively associated with pro-inflammatory biomarkers and negatively associated with some anti-inflammatory dietary factors.
authors.forename: Mackenzie J
authors.initials: MJ
authors.lastname: Bodo
authors.forename: Elizabeth Yakes
authors.initials: EY
authors.lastname: Jimenez
authors.forename: Carole
authors.initials: C
authors.lastname: Conn
authors.forename: Alyssa
authors.initials: A
authors.lastname: Dye
authors.forename: Page
authors.initials: P
authors.lastname: Pomo
authors.forename: Deborah
authors.initials: D
authors.lastname: Kolkmeyer
authors.forename: Robert
authors.initials: R
authors.lastname: Orlando
authors.forename: Alberta S
authors.initials: AS
authors.lastname: Kong
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D018932:Chemokine CCL2 / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood* / Q000503:physiopathology / Q000523:psychology; D050177:Overweight / Q000097:blood* / Q000503:physiopathology / Q000523:psychology; D010865:Pilot Projects; D011379:Prognosis
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D018932:Chemokine CCL2; D006442:Glycated Hemoglobin; C111835:CCL2 protein, human; C517652:hemoglobin A1c protein, human