title: Gut-kidney kaliuretic signaling: looking forward to feeding.
abstract: Preston et al. report urinary potassium excretion in healthy subjects in response to an acute potassium load with or without a meal. The investigators show a rapid kaliuretic response that occurs independently of the serum potassium and plasma aldosterone concentration, and that persists in the presence of a mineralocorticoid receptor blocker. This Commentary puts these data in perspective by reviewing the current understanding of the feedback and feedforward systems that regulate renal potassium excretion.
authors.affiliation: Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Ewout J
authors.initials: EJ
authors.lastname: Hoorn
authors.affiliation: Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Robert
authors.initials: R
authors.lastname: Zietse