title: Effect of Zhuang Jing Decoction on Learning and Memory Ability in Aging Rats.
abstract: With the average life span of humans on the rise, aging in the world has drawn considerable attentions. The monoamine neurotransmitters and neurotrophic factors in brain areas are involved in learning and memory processes and are an essential part of normal synaptic neurotransmission and plasticity. In the present study, the effect of Zhuang Jing Decoction (ZJD) on the learning and memory ability in aging rats was examined in vivo using Morris water maze. Furthermore, the levels of monoamine neurotransmitters and neurotrophic factors in brain were detected by high-performance liquid chromatography with a fluorescence detector and enzyme-linked immunosorbent assay, respectively. These data showed that oral administration with ZJD at the dose of 30 g·kg(-1) exerted an improved effect on learning and memory ability in aging rats. The results revealed that ZJD could effectively adjust the monoamine neurotransmitters and neurotrophic factors, restore the balance of the level of monoamine neurotransmitters and neurotrophic factors in brain, and finally attenuate the degeneration of learning and memory ability. These findings suggested that ZJD might be a potential agent as cognitive-enhancing drug in improving learning and memory ability. It may exert through regulating the levels of monoamine neurotransmitters and neurotrophic factors in brain, which demonstrated that ZJD had certain antiaging effects.
authors.affiliation: 1 Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine , Guangzhou, China .|2 Second Clinical Medical College, Guangzhou University of Chinese Medicine , Guangzhou, China .
authors.forename: Hao-Bin
authors.initials: HB
authors.lastname: Cai
authors.affiliation: 2 Second Clinical Medical College, Guangzhou University of Chinese Medicine , Guangzhou, China .
authors.forename: Guang-Liang
authors.initials: GL
authors.lastname: Wu
authors.affiliation: 3 Youjiang Medical University for Nationalities , Baise, China .
authors.forename: Cen-Han
authors.initials: CH
authors.lastname: Huang
authors.affiliation: 3 Youjiang Medical University for Nationalities , Baise, China .
authors.forename: Zhong-Shi
authors.initials: ZS
authors.lastname: Huang
authors.affiliation: 1 Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine , Guangzhou, China .
authors.forename: Yun-Bo
authors.initials: YB
authors.lastname: Chen
authors.affiliation: 1 Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine , Guangzhou, China .|2 Second Clinical Medical College, Guangzhou University of Chinese Medicine , Guangzhou, China .
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000367:Age Factors; D000375:Aging / Q000378:metabolism / Q000523:psychology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D009414:Nerve Growth Factors / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D013997:Time Factors
chemical_list: D004365:Drugs, Chinese Herbal; D009414:Nerve Growth Factors; C000615777:zhuang jing; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine