title: Total ocular surface amniotic membrane transplantation for paraquat-induced ocular surface injury.
abstract: OBJECTIVE
  To evaluate the therapeutic efficacy of modified amniotic membrane transplantation (MAMT) for paraquat-induced ocular surface injury.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  Thirty patients (30 eyes) with paraquat-induced ocular surface injury.
  
  
  METHODS
  Among the patients, 8 underwent MAMT, 14 received conventional amniotic membrane transplantation (AMT), and 8 were treated with simple drug therapy (DT). Features related to the damage, corneal epithelial defect closure time, visual acuity, stromal haze, and complications were recorded.
  
  
  RESULTS
  In the MAMT and AMT groups, visual acuity in all eyes recovered to the preinjury level; in the DT group, visual acuity in 3 eyes (37.5%) recovered to the preinjury level. The mean corneal epithelial defect closure time was 7.6 ± 2.7 days in the MAMT group, 9.8 ± 3.6 days in the AMT group, and 18.2 ± 5.2 days in the DT group (p < 0.05). There was a significant difference in the symblepharon rate after treatment among the 3 groups (MAMT: 0%, AMT: 35.7%, DT: 87.5%; p < 0.05). Although the tear secretion was reduced in all groups, it was significantly lower in the DT group compared with the MAMT and AMT groups (p < 0.05).
  
  
  CONCLUSIONS
  Paraquat-induced ocular injuries can lead to whole ocular surface damage. MAMT treatment in a timely manner can effectively promote the repair of the ocular surface and reduce the complications from symblepharon.
authors.affiliation: Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.affiliation: Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, China.
authors.forename: Changsen
authors.initials: C
authors.lastname: Liang
authors.affiliation: Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, China.
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Xu
authors.affiliation: Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, China. Electronic address: weiyunshi@163.com.
authors.forename: Weiyun
authors.initials: W
authors.lastname: Shi
mesh_terms: D000650:Amnion / Q000637:transplantation*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002057:Burns, Chemical / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D003229:Conjunctival Diseases / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D003316:Corneal Diseases / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D005126:Eye Burns / Q000139:chemically induced*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006540:Herbicides / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010269:Paraquat / Q000009:adverse effects*; D012189:Retrospective Studies; D013536:Suture Techniques; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D005938:Glucocorticoids; D006540:Herbicides; D010269:Paraquat