title: Incretin-based therapies are associated with acute pancreatitis: Meta-analysis of large randomized controlled trials.
abstract: Previous studies have offered weak and conflicting evidence regarding the impact of incretin-based oral antihyperglycemic agents on risk of acute pancreatitis. This meta-analysis of three recent mega-trials found an 82% increase in the odds of acute pancreatitis with the use of these agents compared to usual care (95% CI, 1.17-2.82).
authors.affiliation: Schulich School of Medicine and Dentistry, Western University, 1465 Richmond St, London, ON N6G 2M1, Canada. Electronic address: proshano@uwo.ca.
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Roshanov
authors.affiliation: Peter Boris Centre for Addictions Research, St Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, ON L8N 4A6, Canada.
authors.forename: Brittany B
authors.initials: BB
authors.lastname: Dennis
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D054795:Incretins / Q000009:adverse effects* / Q000627:therapeutic use; D010195:Pancreatitis / Q000139:chemically induced*; D016032:Randomized Controlled Trials as Topic; D012306:Risk
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D007004:Hypoglycemic Agents; D054795:Incretins
keywords: Acute pancreatitis; DDP4 inhibitors; Gliptins; Incretins; Safety