title: The Impact of UNC5C Genetic Variations on Neuroimaging in Alzheimer's Disease.
abstract: UNC5C, which is a transmembrane receptor for netrin-1 to trigger the apoptosis, has been confirmed as a new risk factor for Alzheimer's disease (AD) recently. However, there is lack of the evidence on the brain structure associated with the polymorphisms of UNC5C in AD. The objective of this study is to investigate the influence of UNC5C loci on the neuroimaging of strategic regions of AD. In 812 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, we explored the genotypes of UNC5C loci in the volumes of the hippocampus, parahippocampal gyrus, posterior cingulate gyrus, middle temporal and precuneus, and the thickness of the entorhinal cortex which are measured by magnetic resonance imaging (MRI). We also investigated the atrophy rate of above structures influenced by UNC5C loci using the longitudinal data. UNC5C loci were associated with the volume of right middle temporal (rs34585936 Pc= 0.0031). Meanwhile, the polymorphisms of UNC5C loci could alter the atrophy rate of strategic regions especially the left hippocampus (rs72672784 Pc= 0.0090; rs13120458 Pc= 0.0434; rs34875919 Pc= 0.0434) and right precuneus (rs72672784 Pc= 0.0068; rs2001246 Pc= 0.0055; rs74690179 Pc= 0.0055). UNC5C genotypes were significantly associated with the volume of the middle temporal on MRI; meanwhile, UNC5C loci could alter the atrophy of strategic regions of AD such as the hippocampus and precuneus. And the above effects of polymorphisms of UNC5C were more obvious in the population with the impaired cognition than those with the normal cognition.
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No.5 Donghai Middle Road, Qingdao, Shandong Province, 266071, China.
authors.forename: Jia-Hao
authors.initials: JH
authors.lastname: Sun
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China.
authors.forename: Hui-Fu
authors.initials: HF
authors.lastname: Wang
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China.
authors.forename: Xi-Chen
authors.initials: XC
authors.lastname: Zhu
authors.affiliation: Department of Radiology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.
authors.forename: Wan-Jiang
authors.initials: WJ
authors.lastname: Yu
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No.5 Donghai Middle Road, Qingdao, Shandong Province, 266071, China.
authors.forename: Chen-Chen
authors.initials: CC
authors.lastname: Tan
authors.affiliation: Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Teng
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No.5 Donghai Middle Road, Qingdao, Shandong Province, 266071, China.
authors.forename: Meng-Shan
authors.initials: MS
authors.lastname: Tan
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No.5 Donghai Middle Road, Qingdao, Shandong Province, 266071, China. dr.tanlan@163.com.|Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China. dr.tanlan@163.com.
authors.forename: Lan
authors.initials: L
authors.lastname: Tan
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No.5 Donghai Middle Road, Qingdao, Shandong Province, 266071, China. yu-jintai@163.com.|Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China. yu-jintai@163.com.|Memory and Aging Center, Department of Neurology, University of California, San Francisco, 675 Nelson Rising Lane, Suite 190, Box 1207, San Francisco, CA, 94158, USA. yu-jintai@163.com.
authors.forename: Jin-Tai
authors.initials: JT
authors.lastname: Yu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D008875:Middle Aged; D000075386:Netrin Receptors / Q000235:genetics*; D059906:Neuroimaging; D009929:Organ Size; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D000075386:Netrin Receptors; C115727:UNC5C protein, human
keywords: ADNI; Alzheimer’s disease; Biomarker; Neuroimaging; UNC5C