title: Benzofuran Small Molecules as Potential Inhibitors of Human Protein Kinases. A Review.
abstract: Kinases are known to regulate the majority of human cellular processes such as communication, division, metabolism, survival and apoptosis therefore they can be promising targets in cancer diseases, viral infection and in other disorders. Small molecules acting as selective human protein kinase inhibitors are very attractive pharmacological targets. This review presents a number of examples of biologically active natural and synthetic benzo[b]furans and their derivatives, such as benzo[b]furan-2- and 3-ones, benzo[b]furan-2- and 3-carboxylic acids, as well as benzo[c]furans as potential inhibitors of various human protein kinases. The pathways of function and implication of the inhibitors in cancer and other diseases are discussed.
authors.affiliation: West Pomeranian University of Technology in Szczecin, Department of Organic Synthesis and Drug Technology, Al. Piastów 42, 71-065 Szczecin, Poland. halina.kwiecien@zut.edu.pl.
authors.forename: Halina
authors.initials: H
authors.lastname: Kwiecień
authors.forename: Agata
authors.initials: A
authors.lastname: Goszczyńska
authors.forename: Paulina
authors.initials: P
authors.lastname: Rokosz
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011494:Protein Kinases / Q000187:drug effects / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D001572:Benzofurans; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases