title: Fetal Pancreatic Stem-Cell Transplant in Patients With Diabetes Mellitus.
abstract: OBJECTIVE
  To determine the efficacy of fetal stem cell transplant for treating patients with diabetes mellitus types 1 and 2.
  
  
  METHODS
  Five patients with diabetes mellitus type 1 and 5 patients with diabetes mellitus type 2 (aged 18-56 years) received a fetal pancreatic stem-cell transplant (cells were 16-18 wk gestation) performed by intravenous infusion at 50 mL/hour. The quantity of fetal stem cells infused was ≥ 5-8*106. We analyzed the patients' C-peptide and glycated hemoglobin levels both before and 3 months after fetal stem cell transplant.
  
  
  RESULTS
  In patients with diabetes mellitus type 1, fetal stem-cell transplant led to a significant increase in C-peptide levels, from 0.09 ± 0.01 ng/mL to 0.20 ± 0.07 ng/mL, after 3 months (P < .008).
  
  
  CONCLUSIONS
  Treatment with fetal pancreatic stem cells may be beneficial for treating patients with type 1 or type 2 diabetes.
authors.affiliation: From the Scientific Department of Internal Medicine, National Scientific Medical Research Center, Astana, Kazakhstan.
authors.forename: Saltanat
authors.initials: S
authors.lastname: Tuganbekova
authors.forename: Olga
authors.initials: O
authors.lastname: Ulyanova
authors.forename: Zhannat
authors.initials: Z
authors.lastname: Taubaldieva
authors.forename: Samat
authors.initials: S
authors.lastname: Saparbayev
authors.forename: Nadezhda
authors.initials: N
authors.lastname: Popova
authors.forename: Larissa
authors.initials: L
authors.lastname: Kozina
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D053686:Fetal Stem Cells / Q000637:transplantation*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000379:methods*; D033581:Stem Cell Transplantation / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D002096:C-Peptide; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human