title: Interstudy repeatability of self-gated quantitative myocardial perfusion MRI.
abstract: To evaluate the interstudy repeatability of multislice quantitative cardiovascular magnetic resonance myocardial blood flow (MBF), myocardial perfusion reserve (MPR), and extracellular volume (ECV). A unique saturation recovery self-gated acquisition was used for the perfusion scans.
  
  
  
  An ungated golden angle radial turboFLASH pulse sequence was used to scan 10 subjects on two separate days on a 3T scanner. A single saturation pulse was followed by a set of four slices. Rest and hyperemia scans were acquired during free breathing. The images were reconstructed using an iterative algorithm with spatiotemporal constraints. The ungated images were retrospectively binned (self-gated) into near-systole and near-diastole. Deformable registration was performed to adjust for respiratory and residual cardiac motion, and the data were fit with a Fermi model to estimate the interstudy repeatability of quantitative self-gated MBF and MPR.
  
  
  
  The coefficient of variation (CoV) of the territorial MPR using the self-gated near-systole data was 18.6%. The self-gated near-diastole data gave less good CoV of MPR, equal to 46.2%. For MBFs, and using smaller (segmental) regions, the CoVs were 20.1% and 22.7% for the estimation of myocardial blood flow at stress and rest, respectively, using the self-gated near-systole data. The self-gated near-diastole data gave CoV = 48.6% and 44.9% for stress and rest.
  
  
  
  The self-gated free-breathing technique for quantification of myocardial blood flow showed good repeatability for near-systole, with results comparable to published studies on interstudy repeatability of quantitative myocardial perfusion MRI using ECG-gating and breath-holds. Self-gated near-diastole data results were less repeatable. J. Magn. Reson. Imaging 2016;43:1369-1378.
authors.affiliation: Utah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Devavrat
authors.initials: D
authors.lastname: Likhite
authors.affiliation: Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Promporn
authors.initials: P
authors.lastname: Suksaranjit
authors.affiliation: Utah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Ganesh
authors.initials: G
authors.lastname: Adluru
authors.affiliation: Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Hu
authors.affiliation: Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Cindy
authors.initials: C
authors.lastname: Weng
authors.affiliation: Utah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Eugene
authors.initials: E
authors.lastname: Kholmovski
authors.affiliation: Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: McGann
authors.affiliation: Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Brent
authors.initials: B
authors.lastname: Wilson
authors.affiliation: Utah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, Utah, USA.|Department of Bioengineering, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Edward
authors.initials: E
authors.lastname: DiBella
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology*; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: ECG-gating; MRI myocardial perfusion; interstudy repeatability; quantitative perfusion; self-gated