title: The calcium-signaling toolkit: Updates needed.
abstract: Here, we review the role of Ca(2+) in apoptosis, namely that ER Ca(2+) depletion or a sustained elevation of cytosolic or mitochondrial Ca(2+) concentration are sufficient to trigger apoptosis. These concepts have emerged by the use of ER stressor agents that decrease the ER Ca(2+) pool by inhibiting SERCA pumps. However, aside from their well-known actions on Ca(2+) homeostasis disruption leading to apoptosis, new evidence show that some ER Ca(2+) modulators have significant implications in other Ca(2+)-mediated or Ca(2+)-independent pathways determining cell fate suggesting a more complex regulation of apoptosis by intracellular Ca(2+). Here, we discuss the crucial interplay between Ca(2+) mediated apoptosis, the Unfold Protein Response and autophagy determining cell fate, and the molecular compounds that have been used to depict these pathways. This review of the literature clearly shows the need for new inhibitors that do not interfere concomitantly with autophagy and Ca(2+) signaling. This article is part of a Special Issue entitled: Calcium and Cell Fate. Guest Editors: Jacques Haiech, Claus Heizmann, Joachim Krebs, Thierry Capiod and Olivier Mignen.
authors.affiliation: Inserm U1003, Equipe labellisée par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université des Sciences et Technologies de Lille (USTL), Villeneuve d'Ascq, 59650 France, Laboratory of Excellence, Ion Channels Science and Therapeutics, France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Dubois
authors.affiliation: Inserm U1003, Equipe labellisée par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université des Sciences et Technologies de Lille (USTL), Villeneuve d'Ascq, 59650 France, Laboratory of Excellence, Ion Channels Science and Therapeutics, France.
authors.forename: Natalia
authors.initials: N
authors.lastname: Prevarskaya
authors.affiliation: Inserm U1003, Equipe labellisée par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université des Sciences et Technologies de Lille (USTL), Villeneuve d'Ascq, 59650 France, Laboratory of Excellence, Ion Channels Science and Therapeutics, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Vanden Abeele
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001343:Autophagy / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000378:metabolism; D056811:Unfolded Protein Response / Q000502:physiology
chemical_list: D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D002118:Calcium
keywords: Apoptosis; Autophagy; Calcium; Inhibitor; SERCA; Unfold Protein Response