title: microRNAs and Personalized Medicine: Evaluating Their Potential as Cancer Biomarkers.
abstract: microRNA deregulations are often, if not invariably, associated with human malignancies, including cancers. Though most of these deregulations may not be functionally implicated in tumorigenesis, the fact that microRNA expression can be monitored in a variety of human specimens, including biological fluids, supports studies aimed at characterizing microRNA signatures able to detect various cancers (diagnosis), predict their outcome (prognosis), monitor their treatment (theranosis), and adapt therapy to a patient (precision medicine). Here, we review and discuss pros and cons of microRNA-based approaches that can support their exploitation as cancer biomarkers.
authors.affiliation: University of Montpellier, 163 rue Auguste Broussonnet, Montpellier, 34090, France. annesaumet@yahoo.fr.|Faculty of Medicine, 2 rue de l'Ecole de Médecine, Montpellier, 34060, France. annesaumet@yahoo.fr.
authors.forename: Anne
authors.initials: A
authors.lastname: Saumet
authors.affiliation: University of Montpellier, 163 rue Auguste Broussonnet, Montpellier, 34090, France. charles.lecellier@igmm.cnrs.fr.|Institute of Molecular Genetics of Montpellier, CNRS UMR 5535, 1919 Route de Mende, Montpellier, 34293, France. charles.lecellier@igmm.cnrs.fr.|Computational Biology Institute, 860 rue de Saint Priest, Montpellier, 34095, France. charles.lecellier@igmm.cnrs.fr.
authors.forename: Charles-Henri
authors.initials: CH
authors.lastname: Lecellier
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D057285:Precision Medicine / Q000379:methods* / Q000639:trends; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: Cancer; Diagnosis; Precision medicine; Prognosis; Theranosis; Tumorigenesis