title: [Impact of sitagliptin on aspirin resistance in patients with Type 2 diabetes mellitus].
abstract: OBJECTIVE
  To explore the impact of sitagliptin on aspirin resistance (AR) in patients with Type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  A total of 68 cases of AR were chosen from 136 cases of T2DM patients. The clinical data, including blood samples, fasting plasma glucose (FPG), glycosylated hemoglobin (HbAlc), and high sensitive C reactive protein (hs-CRP) were collected. Aenosine diphosphate (ADP) and arachidonic acid (AA) -induced platelet aggregation rate (PAG) were detected in 1, 3, 6 and 12 months after the treatment to evaluate the impact of sitagliptin on AR.
  
  
  RESULTS
  After 6 months of hypoglycemic treatment, FPG and HbAlc in two groups were at the normal level. The hypoglycemic effect was not obviously different (P>0.05), but the hsCRP and ADP or AA-induced PAG were decreased in the sitagliptin group with statistical significance when compared with the metformin group (P<0.05).
  
  
  CONCLUSIONS
  Sitagliptin can significantly improve the oxidative stress inflammatory state in T2DM patients and AR, which is independent on blood glucose control.
authors.affiliation: Department of Nursing, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Nursing, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Lezhi
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Nursing, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Meijun
authors.initials: M
authors.lastname: Ou
authors.affiliation: Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Chenyang
authors.initials: C
authors.lastname: Chen
mesh_terms: D001241:Aspirin / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004351:Drug Resistance; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008687:Metformin / Q000494:pharmacology; D018384:Oxidative Stress; D000068900:Sitagliptin Phosphate / Q000494:pharmacology*
chemical_list: D001241:Aspirin; D001786:Blood Glucose; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D008687:Metformin; D000068900:Sitagliptin Phosphate