title: Neurological Effects of Bisphenol A and its Analogues.
abstract: The endocrine disrupting chemical bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. The use of BPA-containing products in daily life makes exposure ubiquitous, and the potential human health risks of this chemical are a major public health concern. Although numerous in vitro and in vivo studies have been published on the effects of BPA on biological systems, there is controversy as to whether ordinary levels of exposure can have adverse effects in humans. However, the increasing incidence of developmental disorders is of concern, and accumulating evidence indicates that BPA has detrimental effects on neurological development. Other bisphenol analogues, used as substitutes for BPA, are also suspected of having a broad range of biological actions. The objective of this review is to summarize our current understanding of the neurobiological effects of BPA and its analogues, and to discuss preventive strategies from a public health perspective.
authors.affiliation: Department of Public Health, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Hidekuni
authors.initials: H
authors.lastname: Inadera
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity* / Q000652:urine; D004781:Environmental Exposure / Q000032:analysis; D004784:Environmental Monitoring; D005260:Female; D015386:Hazardous Substances / Q000633:toxicity / Q000652:urine; D006801:Humans; D008297:Male; D009420:Nervous System / Q000187:drug effects* / Q000254:growth & development*; D065886:Neurodevelopmental Disorders / Q000139:chemically induced; D010636:Phenols / Q000633:toxicity* / Q000652:urine; D011634:Public Health; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D015386:Hazardous Substances; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Epigenetics; Neurodevelopment