title: Authors' reply to Upton.
authors.affiliation: National Institute for Health Research (NIHR) Greater Manchester Primary Care Patient Safety Translational Research Centre, Centre for Primary Care, Institute of Population Health, University of Manchester, Manchester M13 9PL, UK jill.stocks@manchester.ac.uk.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Stocks
authors.affiliation: NIHR School for Primary Care Research, Centre for Primary Care, Institute of Population Health, University of Manchester Centre for Health Informatics, Institute of Population Health, University of Manchester.
authors.forename: Evangelos
authors.initials: E
authors.lastname: Kontopantelis
authors.affiliation: Centre for Health Informatics, Institute of Population Health, University of Manchester.
authors.forename: Artur
authors.initials: A
authors.lastname: Akbarov
authors.affiliation: Division of Primary Care, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Rodgers
authors.affiliation: Division of Primary Care, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, UK.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Avery
authors.affiliation: Centre for Pharmacoepidemiology and Drug Safety, Manchester Pharmacy School, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester.
authors.forename: Darren M
authors.initials: DM
authors.lastname: Ashcroft
mesh_terms: D005194:Family Practice / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D019300:Medical Errors / Q000706:statistics & numerical data*; D061214:Patient Safety / Q000592:standards*; D010818:Practice Patterns, Physicians' / Q000592:standards*; D055553:Prescription Drugs / Q000627:therapeutic use*
chemical_list: D055553:Prescription Drugs