title: Plasmacytoid dendritic cells in allogeneic hematopoietic cell transplantation: benefit or burden?
abstract: Plasmacytoid dendritic cells (pDCs) bridge innate and adaptive immune responses and have important roles in hematopoietic engraftment, GvHD and graft-versus-leukemia responses following allogeneic hematopoietic cell transplantation (HCT). In addition, pDCs mediate antiviral immunity, particularly as they are the body's primary cellular source of type I interferon. Given their pleiotropic roles, pDCs have emerged as cells that critically impact transplant outcomes, including overall survival. In this article, we will review the pre-clinical and clinical literature, supporting the crucial roles that pDCs assume as key immune effector cells during HCT.
authors.affiliation: Host Defense Program, Hematology/Oncology/Bone Marrow Transplant and Infectious Diseases, Nationwide Children's Hospital, Columbus, OH, USA.|The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.|Departments of Pediatrics and Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Auletta
authors.affiliation: The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.|Blood and Marrow Transplant Program, The James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.|Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Devine
authors.affiliation: Bone Marrow and Stem Cell Transplant Program, Winship Cancer Institute, Atlanta, GA, USA.|Departments of Medicine, Pathology, and Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: E K
authors.initials: EK
authors.lastname: Waller
mesh_terms: D064591:Allografts; D003713:Dendritic Cells / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D010950:Plasma Cells / Q000276:immunology*; D014777:Virus Diseases / Q000209:etiology / Q000276:immunology