title: Biological modeling of mucus to modulate mucus barriers.
abstract: A recent study using a transgenic mouse, whose intestinal mucus contains a molecule made of 12 copies of a domain found in many gelling mucins, demonstrates that it is possible to strengthen mucus properties in situ, leading to promising new treatment strategies in diseases in which the mucosal barrier is impaired.
authors.affiliation: LIRIC-UMR 995, Inserm, University of Lille, Lille, France jean-luc.desseyn@inserm.fr.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Desseyn
authors.affiliation: LIRIC-UMR 995, Inserm, University of Lille, Lille, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Gouyer
authors.affiliation: LIRIC-UMR 995, Inserm, University of Lille, Lille, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Gottrand
mesh_terms: D000818:Animals; D000069196:Gastrointestinal Microbiome / Q000276:immunology*; D007413:Intestinal Mucosa / Q000378:metabolism*; D055262:Mucin-2 / Q000378:metabolism*; D009093:Mucus / Q000378:metabolism*; D019108:Tight Junctions / Q000502:physiology*
chemical_list: D055262:Mucin-2
keywords: gelling mucin; mucin CYS domain; mucosal barrier; mucus; transgenic mouse