title: Suspended Planar-Array Chips for Molecular Multiplexing at the Microscale.
abstract: A novel suspended planar-array chips technology is described, which effectively allows molecular multiplexing using a single suspended chip to analyze extraordinarily small volumes. The suspended chips are fabricated by combining silicon-based technology and polymer-pen lithography, obtaining increased molecular pattern flexibility, and improving miniaturization and parallel production. The chip miniaturization is so dramatic that it permits the intracellular analysis of living cells.
authors.affiliation: Instituto de Microelectrónica de Barcelona, IMB-CNM (CSIC), C/dels Til·lers, Campus UAB, Cerdanyola del Vallès, Barcelona, 08193, Spain.
authors.forename: Núria
authors.initials: N
authors.lastname: Torras
authors.affiliation: Nanobioengineering Group, Institute for Bioengineering of Catalonia (IBEC), C/Baldiri i Reixac 15-21, Barcelona, 08028, Spain.
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Agusil
authors.affiliation: Centro de Investigaciones Biológicas, CIB (CSIC), C/Ramiro de Maeztu 9, Madrid, 28040, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Vázquez
authors.affiliation: Instituto de Microelectrónica de Barcelona, IMB-CNM (CSIC), C/dels Til·lers, Campus UAB, Cerdanyola del Vallès, Barcelona, 08193, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Duch
authors.affiliation: Centro de Investigaciones Biológicas, CIB (CSIC), C/Ramiro de Maeztu 9, Madrid, 28040, Spain.
authors.forename: Alberto M
authors.initials: AM
authors.lastname: Hernández-Pinto
authors.affiliation: Nanobioengineering Group, Institute for Bioengineering of Catalonia (IBEC), C/Baldiri i Reixac 15-21, Barcelona, 08028, Spain.|Department d'Electrònica, Universitat de Barcelona, C/Martí i Franquès 1, Barcelona, 08028, Spain.|Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), C/María de Luna 11, Edificio CEEI, Zaragoza, 50018, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Samitier
authors.affiliation: Centro de Investigaciones Biológicas, CIB (CSIC), C/Ramiro de Maeztu 9, Madrid, 28040, Spain.
authors.forename: Enrique J
authors.initials: EJ
authors.lastname: de la Rosa
authors.affiliation: Instituto de Microelectrónica de Barcelona, IMB-CNM (CSIC), C/dels Til·lers, Campus UAB, Cerdanyola del Vallès, Barcelona, 08193, Spain.
authors.forename: Jaume
authors.initials: J
authors.lastname: Esteve
authors.affiliation: Centro de Investigaciones Biológicas, CIB (CSIC), C/Ramiro de Maeztu 9, Madrid, 28040, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Suárez
authors.affiliation: Departament de Farmacologia i Química Terapèutica, Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, Av. Joan XXIII s/n, Barcelona, 08028, Spain.
authors.forename: Lluïsa
authors.initials: L
authors.lastname: Pérez-García
authors.affiliation: Instituto de Microelectrónica de Barcelona, IMB-CNM (CSIC), C/dels Til·lers, Campus UAB, Cerdanyola del Vallès, Barcelona, 08193, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Plaza
mesh_terms: D006367:HeLa Cells; D006801:Humans; D056656:Lab-On-A-Chip Devices; D011108:Polymers / Q000737:chemistry; D011327:Printing
chemical_list: D011108:Polymers
keywords: chip-in-a-cell; planar-arrays; silicon chips; single-cell analysis; suspended-arrays