title: SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients.
abstract: BACKGROUND
  Serine hydroxymethyltransferase 1 (SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon unit. SHMT1 C1420T may lead to the abnormal biosynthesis involved in DNA synthesis and methylation, and it may eventually increase cancer susceptibility. Many epidemiologic studies have explored the association between C1420T polymorphism and the risk of non-Hodgkin lymphoma (NHL), but the results have been contradictory. Therefore, we performed this meta-analysis to evaluate the relationship.
  
  
  METHODS
  The meta-analyses were conducted to evaluate the effect of SHMT1 C1420T polymorphism on NHL risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure the strength of the association.
  
  
  RESULTS
  Eight studies encompassing 3232 cases and 4077 controls were included. A statistically significant association was found between SHMT1 C1420T polymorphism and NHL risk under the allelic comparison (T vs. C: OR = 1.09, 95% CI 1.01-1.17); a borderline association was found between SHMT1 C1420T polymorphism and NHL risk under the homozygote model (TT vs. CC: OR = 1.18, 95% CI 1.00-1.39) and the dominant model (CT+TT vs. CC: OR = 1.10, 95% CI 1.00-1.21).
  
  
  CONCLUSIONS
  SHMT1 C1420T polymorphism may be associated with NHL risk, which needs to be validated in large, prospective studies.
authors.affiliation: Department of Oncology, Xin Hua Hospital Affiliated To Shanghai Jiaotong University School of Medicine, NO. 1665, Kong Jiang Road, Shanghai, 200092, P.R. China. wywxrbnm@163.com.
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Wang
authors.affiliation: Department of Experimental Research, State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P.R. China. zhangsd@sysucc.org.cn.
authors.forename: Shao-Dan
authors.initials: SD
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Xin Hua Hospital Affiliated To Shanghai Jiaotong University School of Medicine, NO. 1665, Kong Jiang Road, Shanghai, 200092, P.R. China. 570208743@qq.com.
authors.forename: Wen-Ji
authors.initials: WJ
authors.lastname: Xue
authors.affiliation: Department of Oncology, Xin Hua Hospital Affiliated To Shanghai Jiaotong University School of Medicine, NO. 1665, Kong Jiang Road, Shanghai, 200092, P.R. China. anniezhu_79@163.com.
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Zhu
authors.affiliation: Department of Oncology, Xin Hua Hospital Affiliated To Shanghai Jiaotong University School of Medicine, NO. 1665, Kong Jiang Road, Shanghai, 200092, P.R. China. zhengleizhen_xh@hotmail.com.
authors.forename: Lei-Zhen
authors.initials: LZ
authors.lastname: Zheng
mesh_terms: D016022:Case-Control Studies; D019317:Evidence-Based Medicine / Q000379:methods; D020022:Genetic Predisposition to Disease; D012696:Glycine Hydroxymethyltransferase / Q000235:genetics*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012680:Sensitivity and Specificity
chemical_list: D009363:Neoplasm Proteins; D012696:Glycine Hydroxymethyltransferase; C520541:SHMT protein, human