title: Determination of Risk Factors for Pre-eclampsia and Eclampsia in a Tertiary Hospital of India: A Case Control Study.
abstract: BACKGROUND
  Preeclampsia and eclampsia (PE) are pregnancy specific syndromes that contribute to maternal and fetal morbidity and mortality. The identification of its predisposing factors in the pre-pregnancy and initial stage of pregnancy will help in reducing the morbidity and mortality.
  
  
  OBJECTIVE
  The aim of this study is to determine the risk factors for PE among pregnant women in a tertiary level hospital.
  
  
  METHODS
  In this study, 122 women who delivered beyond 22 weeks of gestation and diagnosed as preeclampsia or eclampsia were selected. Simultaneously, 122 controls with no diagnosis of preeclampsia or eclampsia were selected from the post natal ward. Cases and controls were administered the same pre-tested questionnaire containing different risk factors.
  
  
  CONCLUSIONS
  Logistic regression was applied in the statistical analysis. The factors that were found to be significant predictors of risk for development of PE were family history of preeclampsia (adjusted odds ratio [OR] 18.57 [1.93-178.16], P = 0.011), higher calorie intake (adjusted OR 14.12 [6.41-43.23] body mass index (adjusted P < 0.001), employment (adjusted OR 6.35 [1.56-25.82] P = 0.010], less protein intake (adjusted OR 3.87 [1.97-8.01] P < 0.001), increased OR 5.86 [02.48-13.8] P < 0.001), mild physical activities (adjusted OR 3.46 [1.06-11.24] P = 0.039). Past history of hypertension and diabetes mellitus were also associated with development of PE.
authors.affiliation: Department of Community Medicine, North Delhi Municipal Corporation Medical College, New Delhi, India.
authors.forename: Punyatoya
authors.initials: P
authors.lastname: Bej
authors.affiliation: Department of Community Medicine, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi, India.
authors.forename: Pragti
authors.initials: P
authors.lastname: Chhabra
authors.affiliation: Department of Community Medicine, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi, India.
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Sharma
authors.affiliation: Department of Obstetric-Gynaecology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Guleria
keywords: Case control study; eclampsia; multiple logistic regression; preeclampsia; risk factors