title: Two Ways to Get Mad at Kinetochores.
abstract: The spindle assembly checkpoint ensures that mitotic cells only segregate their sister chromatids once all chromosomes are attached via kinetochores by microtubules of the mitotic spindle. Reporting in Developmental Cell, Silió et al. (2015) show that in human cells the signaling cascade controlling the checkpoint operates through two separate branches.
authors.affiliation: Cell Physiology and Metabolism Department, University of Geneva, Geneva CH-1211, Switzerland. Electronic address: patrick.meraldi@unige.ch.
authors.forename: Patrick
authors.initials: P
authors.lastname: Meraldi
mesh_terms: D018797:Cell Cycle Proteins / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D008869:Microtubule-Associated Proteins