title: Bioengineered silk scaffolds in 3D tissue modeling with focus on mammary tissues.
abstract: In vitro generation of three-dimensional (3D) biological tissues and organ-like structures is a promising strategy to study and closely model complex aspects of the molecular, cellular, and physiological interactions of tissue. In particular, in vitro 3D tissue modeling holds promises to further our understanding of breast development. Indeed, biologically relevant 3D structures that combine mammary cells and engineered matrices have improved our knowledge of mammary tissue growth, organization, and differentiation. Several polymeric biomaterials have been used as scaffolds to engineer 3D mammary tissues. Among those, silk fibroin-based biomaterials have many biologically relevant properties and have been successfully used in multiple medical applications. Here, we review the recent advances in engineered scaffolds with an emphasis on breast-like tissue generation and the benefits of modified silk-based scaffolds.
authors.affiliation: Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.
authors.forename: Yas
authors.initials: Y
authors.lastname: Maghdouri-White
authors.affiliation: Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, USA.
authors.forename: Gary L
authors.initials: GL
authors.lastname: Bowlin
authors.affiliation: Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Lemmon
authors.affiliation: Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA. Electronic address: ddreau@uncc.edu.
authors.forename: Didier
authors.initials: D
authors.lastname: Dréau
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D012831:Bombyx; D005349:Fibroins; D021621:Imaging, Three-Dimensional; D057139:Nanofibers; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D005349:Fibroins
keywords: Breast tissue modeling; Electrospinning; Nanofibers; Scaffolds; Silk fibroin; Three-dimensional modeling; Tissue engineering