title: microRNA and NF-kappa B.
abstract: Nuclear Factor kappa B (NF-κB) plays important roles in regulation of countless cellular functions, including cell cycle and apoptosis. As a versatile transcription factor, NF-κB is a target of a large amount of miRNAs. Abnormal NF-κB activity is frequently associated with an abnormal level of miRNAs, which is found to play critical roles in disease progression including cancer. While the expression and activity of NF-κB can be directly or indirectly up-regulated or downregulated by various miRNAs, NF-κB can also regulate the expression of many miRNAs. Intriguingly, reciprocal regulation between miRNAs and NF-κB, which exists in the form of positive and negative feedback loops, is often observed in various cancers. In this chapter, the mechanisms and roles of miRNA-regulated NF-κB and NF-κB-regulated miRNAs in a variety of cancers will be discussed. The potential therapeutic use of miRNAs that are up- and down-stream of NF-κB signaling pathways as targets for cancer treatment will also be accessed.
authors.affiliation: Edison Biotechnology Institute, Konneker Research Center, Ohio University, Athens, OH, 45701, USA. yy569210@ohio.edu.|Department of Chemistry and Biochemistry, Ohio University, Athens, OH, 45701, USA. yy569210@ohio.edu.
authors.forename: Ye
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Edison Biotechnology Institute, Konneker Research Center, Ohio University, Athens, OH, 45701, USA. lt199609@ohio.edu.
authors.forename: Lingying
authors.initials: L
authors.lastname: Tong
authors.affiliation: Edison Biotechnology Institute, Konneker Research Center, Ohio University, Athens, OH, 45701, USA. wus1@ohio.edu.|Department of Chemistry and Biochemistry, Ohio University, Athens, OH, 45701, USA. wus1@ohio.edu.
authors.forename: Shiyong
authors.initials: S
authors.lastname: Wu
mesh_terms: D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D016328:NF-kappa B / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D016328:NF-kappa B
keywords: Angiogenesis; Apoptosis; Cancer; Carcinogens; Cell cycle; NF-κB; Therapeutics