title: Catalytic Enantioselective Synthesis of N-C Axially Chiral Phenanthridin-6-one Derivatives.
abstract: N-C axially chiral phenanthridin-6-one derivatives bearing various ortho-substituted phenyl groups on the nitrogen atom were enantioselectively prepared through (R)-DTBM-SEGPHOS-Pd(OAc)2-catalyzed intramolecular Buchwald-Hartwig amination. The enantioselectivity strongly depended on solvents, bases, and reaction temperature as well as on the bulkiness of ortho-substituents.
authors.affiliation: Department of Applied Chemistry, Shibaura Institute of Technology , 3-7-5 Toyosu, Kohto-ku, Tokyo, 135-8548, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Hirata
authors.affiliation: Department of Applied Chemistry, Shibaura Institute of Technology , 3-7-5 Toyosu, Kohto-ku, Tokyo, 135-8548, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Takahashi
authors.affiliation: Department of Applied Chemistry, Shibaura Institute of Technology , 3-7-5 Toyosu, Kohto-ku, Tokyo, 135-8548, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Department of Applied Chemistry, Shibaura Institute of Technology , 3-7-5 Toyosu, Kohto-ku, Tokyo, 135-8548, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yoshida
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1, Horinouchi, Hachioji, Tokyo, 192-0392, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hasegawa
authors.affiliation: Department of Applied Chemistry, Shibaura Institute of Technology , 3-7-5 Toyosu, Kohto-ku, Tokyo, 135-8548, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Kitagawa