title: An analytical model for nanoparticles concentration resulting from infusion into poroelastic brain tissue.
abstract: We consider the infusion of a diluted suspension of nanoparticles (NPs) into poroelastic brain tissue, in view of relevant biomedical applications such as intratumoral thermotherapy. Indeed, the high impact of the related pathologies motivates the development of advanced therapeutic approaches, whose design also benefits from theoretical models. This study provides an analytical expression for the time-dependent NPs concentration during the infusion into poroelastic brain tissue, which also accounts for particle binding onto cells (by recalling relevant results from the colloid filtration theory). Our model is computationally inexpensive and, compared to fully numerical approaches, permits to explicitly elucidate the role of the involved physical aspects (tissue poroelasticity, infusion parameters, NPs physico-chemical properties, NP-tissue interactions underlying binding). We also present illustrative results based on parameters taken from the literature, by considering clinically relevant ranges for the infusion parameters. Moreover, we thoroughly assess the model working assumptions besides discussing its limitations. While not laying any claims of generality, our model can be used to support the development of more ambitious numerical approaches, towards the preliminary design of novel therapies based on NPs infusion into brain tissue.
authors.affiliation: Istituto Italiano di Tecnologia, Center for Micro-BioRobotics, Viale R. Piaggio 34, 56025 Pontedera, Italy; Scuola Superiore Sant'Anna, The BioRobotics Institute, Viale R. Piaggio 34, 56025 Pontedera, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pizzichelli
authors.affiliation: Istituto Italiano di Tecnologia, Center for Micro-BioRobotics, Viale R. Piaggio 34, 56025 Pontedera, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Di Michele
authors.affiliation: Istituto Italiano di Tecnologia, Center for Micro-BioRobotics, Viale R. Piaggio 34, 56025 Pontedera, Italy. Electronic address: edoardo.sinibaldi@iit.it.
authors.forename: E
authors.initials: E
authors.lastname: Sinibaldi
mesh_terms: D001921:Brain / Q000187:drug effects*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008962:Models, Theoretical; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000628:therapy*
keywords: Analytical model; Brain infusion; Nanoparticles concentration; Nanoparticles hyperthermia; Poroelasticity