title: MULTICENTRIC T-CELL LYMPHOMA AND CUTANEOUS HEMANGIOSARCOMA IN A CAPTIVE CHEETAH (ACINONYX JUBATUS).
abstract: A 13-yr-old intact male cheetah (Acinonyx jubatus) presented for evaluation after a 4-mo history of intermittent lethargy and increased expiratory effort. The clinical signs were initially noted after the diagnosis and death of its 13-yr-old male sibling with solitary hepatic T-cell lymphoma. Physical examination findings included thin body condition, harsh lung sounds, peripheral lymphadenopathy, and a cutaneous mass on the right medial tarsus and scrotum. Excisional biopsies diagnosed well-differentiated cutaneous hemangiosarcomas. Thoracic radiographs revealed a cranial mediastinal mass. Complete blood count and serum biochemical analyses showed a leukocytosis with persistent lymphocytosis, progressive azotemia, and markedly elevated alkaline phosphatase. Because of the cheetah's declining quality of life, euthanasia was elected. Postmortem examination, histopathology, and immunohistochemical staining revealed multicentric T-cell lymphoma. Feline leukemia virus (FeLV) enzyme-linked immunosorbent assay, FeLV polymerase chain reaction (whole blood), and viral metagenomic analysis were negative. This is the first case of cutaneous hemangiosarcoma and multicentric T-cell lymphoma reported in a FeLV-negative cheetah.
authors.forename: Dana M
authors.initials: DM
authors.lastname: Lindemann
authors.forename: James W
authors.initials: JW
authors.lastname: Carpenter
authors.forename: Jerome C
authors.initials: JC
authors.lastname: Nietfeld
authors.forename: Estehela
authors.initials: E
authors.lastname: Gonzalez
authors.forename: Mackenzie
authors.initials: M
authors.lastname: Hallman
authors.forename: Ben M
authors.initials: BM
authors.lastname: Hause
mesh_terms: D002612:Acinonyx; D000818:Animals; D006394:Hemangiosarcoma / Q000662:veterinary*; D016399:Lymphoma, T-Cell / Q000662:veterinary*; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology / Q000662:veterinary*
keywords: Acinonyx jubatus; T-cell lymphoma; cheetah; hemangiosarcoma; metagenomics