title: [Change on burden of diseases from hypercholesterolemia among the Chinese population from 1990 to 2010].
abstract: OBJECTIVE
  To quantify the change on burden of disease from hypercholesterolemia in China from 1990 to 2010.
  
  
  METHODS
  Related data were obtained from the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010). Population attributable risk was adopted to estimate the burden of disease from hypercholesterolemia.
  
  
  RESULTS
  The death and burden of disease from hypercholesterolemia for Chinese residents increased from 98 000 and 2.237 million disability-adjusted of life years (DALY) in 1990 to 281 000 and 5.912 million DALY respectively. In 2010, 251 000 ischemic heart disease and 30 000 ischemic stroke deaths were caused by hypercholesterolemia, accounted for 3.4% (28.1/830.2) of the total deaths. In 2010, the DALY of ischemic heart disease and ischemic stroke attributed to hypercholesterolemia was 5.169 million and 0.743 million respectively. DALY was 3.356 million in male and 2.555 million in female. Years of life lost due to premature mortality (YLL) was 5.268 million, and years lived with disability (YLD) was 0.644 million.
  
  
  CONCLUSIONS
  Hypercholesterolemia is a major risk factor for deaths and life loss in 2010, and the burden of disease and death from hypercholesterolemia increased obviously from 1990 to 2010 in China.
authors.affiliation: National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Mingbo
authors.initials: M
authors.lastname: Liu
authors.affiliation: National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Wang
authors.affiliation: National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Liyuan
authors.initials: L
authors.lastname: Ma
authors.affiliation: National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; Email: maigengzhou@126.com.
authors.forename: Maigeng
authors.initials: M
authors.lastname: Zhou
mesh_terms: D044466:Asian People; D002681:China; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia; D008297:Male; D019057:Quality-Adjusted Life Years; D012307:Risk Factors; D020521:Stroke