title: Severity of white matter hyperintensities in older adults aged in their mid 80s and its relationship with hemodynamic and cardiac parameters.
abstract: OBJECTIVE
  In the present study, we analyzed the severity of white matter hyperintensities detected on magnetic resonance imaging of the brain in older Japanese adults who were aged in their mid 80s, and examined its relationships with the clinical parameters.
  
  
  METHODS
  To identify factors related to the severity of white matter hyperintensities in 33 older adult attendees of our outpatient clinic and 17 older adults living in a group home, we carried out logistic regression analyses and/or correlation analyses.
  
  
  RESULTS
  Cognitive function and activities of daily living were significantly correlated with the severity of white matter hyperintensities. Multivariate analysis identified activities of daily living, but not cognitive function, as being independently associated with the severity of white matter hyperintensities. Several hemodynamic and cardiac parameters, including diastolic blood pressure, hemoglobin, serum level of N-terminal pro-brain natriuretic peptide, cardiothoracic ratio on the chest X-ray, severity of supraventricular arrhythmias on a Holter electrocardiogram and serum levels of docosahexaenoic acid, were significantly correlated with the severity of white matter hyperintensities. In contrast, the serum cholesterol, glycosylated hemoglobin value and systolic blood pressure were not correlated with the severity of white matter hyperintensities.
  
  
  CONCLUSIONS
  The severity of white matter hyperintensities detected on magnetic resonance imaging of the brain in older Japanese patients aged in their mid 80s was significantly correlated with activities of daily living, hemodynamic and cardiac parameters, and the serum level of docosahexaenoic acid.
authors.affiliation: Department of Physiology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Kikue
authors.initials: K
authors.lastname: Todoroki
authors.affiliation: Department of Physiology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Yoshimori
authors.initials: Y
authors.lastname: Ikeya
authors.affiliation: Department of Physiology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Sayato
authors.initials: S
authors.lastname: Fukui
authors.affiliation: Department of Radiology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Noriharu
authors.initials: N
authors.lastname: Yanagimachi
authors.affiliation: Department of Radiology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Okazaki
authors.affiliation: Department of Physiology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Chiharu
authors.initials: C
authors.lastname: Tanaka
authors.affiliation: Department of Nutritional Science, Tokyo University of Agriculture, Tokyo, Japan.
authors.forename: Etsuro
authors.initials: E
authors.lastname: Tanaka
authors.affiliation: Department of Physiology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Shizuma
authors.affiliation: Department of Physiology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Fukuyama
authors.affiliation: Department of Physiology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Hidezo
authors.initials: H
authors.lastname: Mori
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D015577:Geriatric Assessment / Q000379:methods; D006334:Heart Function Tests; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007564:Japan; D049292:Leukoaraiosis / Q000473:pathology / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D018570:Risk Assessment; D012737:Sex Factors; D066127:White Matter / Q000473:pathology*
keywords: activities of daily living; cognitive function; elderly; hemodynamics; white matter hyperintensities