title: [Expression and clinical significance of BCL6 corepressor-like 1 in non-small cell lung cancer].
abstract: OBJECTIVE
  To detect the expression of BCL6 corepressor-like 1 (BCORL1) in tumor tissues of human non-small cell lung cancer (NSCLC) and determine the effect of BCORL1 on cell migration and invasion in A549 cells by knockdown of BCORL1.
  
  
  METHODS
  Sixty-eight pairs of NSCLC and nontumor tissues were collected and the expressions of BCORL1 and E-cadherin in them were detected using immunohistochemical staining. The expression of BCORL1 was knocked down by siRNA in A549 cells. Transwell(TM) assays were performed to test NSCLC cell migration and invasion in vitro.
  
  
  RESULTS
  The expression of BCORL1 in NSCLC was significantly higher than that in paired noncancerous tissues, while E-cadherin was down-regulated in NSCLC as compared with nontumor tissues. Pearson correlation coefficient analysis suggested that BCORL1 was negatively correlated with E-cadherin expression in NSCLC tissues. Clinical association analysis suggested that the elevated expression of BCORL1 was evidently associated with the higher incidence of lymph node metastasis and more advanced TNM stage. When the expression of BCORL1 was down-regulated by a specific siRNA, E-cadherin was up-regulated, and BCORL1 knockdown obviously inhibited cell migration and invasion in A549 cells.
  
  
  CONCLUSIONS
  BCORL1 is overexpressed in NSCLC tissues and it is negatively correlated with E-cadherin expression. Its high expression is correlated with poor prognostic features. BCORL1 knockdown up-regulates E-cadherin expression and subsequently inhibits cell migration and invasion of lung cancer cells.
authors.affiliation: Department of Cardiothoracic Surgery, Second Hospital of Yulin City, Yulin 719000, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Tuo
authors.affiliation: Department of Obstetrics and Gynecology, Second Hospital of Yulin City, Yulin 719000, China.
authors.forename: Meili
authors.initials: M
authors.lastname: Si
authors.affiliation: Department of Pathology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cardiothoracic Surgery, Second Hospital of Yulin City, Yulin 719000, China. *Corresponding author, E-mail: khp_smu@163.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Liang
mesh_terms: D000328:Adult; D000368:Aged; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D045744:Cell Line, Tumor; D002465:Cell Movement; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C521111:BCORL1 protein, human; D015820:Cadherins; D012097:Repressor Proteins