title: Hydrogen peroxide vapor room disinfection and hand hygiene improvements reduce Clostridium difficile infection, methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and extended-spectrum β-lactamase.
abstract: We report a statistically significant reduction in Clostridium difficile infection (from 1.38 to 0.90 cases per 1,000 patient days), vancomycin-resistant enterococci (from 0.21 to 0.01 cases per 1,000 patient days), and extended-spectrum β-lactamase-producing gram-negative bacteria (from 0.16 to 0.01 cases per 1,000 patient days) associated with the introduction of hydrogen peroxide vapor for terminal decontamination of patient rooms and improvements in hand hygiene compliance.
authors.affiliation: Flagstaff Medical Center, Flagstaff, AZ. Electronic address: kimberly.horn@nahealth.com.
authors.forename: Kim
authors.initials: K
authors.lastname: Horn
authors.affiliation: Bioquell, Andover, Hampshire, UK; Center Clinical Infection and Diagnostics Research, Department of Infectious Diseases, King's College London, London, UK; Guy's and St Thomas' NHS Foundation Trust, London, UK.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Otter
mesh_terms: D001424:Bacterial Infections / Q000382:microbiology / Q000517:prevention & control*; D016360:Clostridioides difficile / Q000302:isolation & purification; D003428:Cross Infection / Q000382:microbiology / Q000517:prevention & control*; D004202:Disinfectants / Q000008:administration & dosage*; D004203:Disinfection / Q000379:methods*; D006090:Gram-Negative Bacteria / Q000201:enzymology / Q000302:isolation & purification; D063373:Hand Hygiene / Q000379:methods*; D006801:Humans; D006861:Hydrogen Peroxide / Q000008:administration & dosage*; D015994:Incidence; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D011446:Prospective Studies; D065507:Vancomycin-Resistant Enterococci / Q000302:isolation & purification; D014835:Volatilization; D001618:beta-Lactamases / Q000032:analysis
chemical_list: D004202:Disinfectants; D006861:Hydrogen Peroxide; D001618:beta-Lactamases
keywords: Clostridium difficile; Decontamination; Extended-spectrum β-lactamase; Hand hygiene; Hydrogen peroxide vapor; Methicillin-resistant Staphylococcus aureus; Vancomycin-resistant enterococci