title: Gastric Bypass Surgery but not Caloric Restriction Improves Reproductive Function in Obese Mice.
abstract: In women, obesity is associated with decrements in reproductive health that are improved with weight loss. Due to the difficulty of maintaining weight loss through lifestyle interventions, surgical interventions have become popular treatments for obesity. We examined how weight loss induced by Roux-en Y gastric bypass surgery (RYGB) or calorie restriction impacted expression of hypothalamic genes related to energy intake and reproduction. RYGB and calorie restriction induced equivalent weight loss; however, expression of the anorexigenic melanocortin pathway decreased only in calorie restricted mice. Serum estradiol concentrations were lower in calorie restricted mice relative to RYGB during proestrous, suggesting that RYGB maintained normal estrous cycling. Thus, the effects of RYGB for female mice, and possibly humans, extend beyond weight loss to include enhanced reproductive health.
authors.affiliation: Department of Biomedical Sciences, Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA. Aaron.frank@cshs.org.
authors.forename: Aaron P
authors.initials: AP
authors.lastname: Frank
authors.affiliation: Department of Internal Medicine, Division of Digestive and Liver Diseases, Ann Arbor, MI, 48109, USA. Juliet.Fong@UTSouthwestern.edu.|Department of Internal Medicine, Center for Hypothalamic Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA. Juliet.Fong@UTSouthwestern.edu.
authors.forename: Juliet F
authors.initials: JF
authors.lastname: Zechner
authors.affiliation: Department of Internal Medicine, Touchstone Diabetes Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA. deborah.clegg@cshs.org.|Department of Biomedical Sciences, Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA. deborah.clegg@cshs.org.
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Clegg
mesh_terms: D000818:Animals; D031204:Caloric Restriction; D004195:Disease Models, Animal; D004958:Estradiol / Q000097:blood; D005260:Female; D015390:Gastric Bypass; D051379:Mice; D008815:Mice, Inbred Strains; D008820:Mice, Obese; D009765:Obesity / Q000097:blood / Q000150:complications / Q000601:surgery / Q000628:therapy*; D011247:Pregnancy / Q000502:physiology; D055703:Reproductive Physiological Phenomena; D015431:Weight Loss / Q000502:physiology
chemical_list: D004958:Estradiol
keywords: 17beta-estradiol; Agouti-related peptide; Estrogen receptor alpha; Kisspeptin; Neuropeptide Y; Proopiomelanocortin; Reproduction; Roux-en-Y gastric bypass