title: Synthesis and characterization of a novel N-F reagent derived from the ethano-Tröger's base: (1)J(FN) coupling constants as a signature for the N-F bond.
abstract: Methylation of 2,8-dimethyl-6H,12H-5,11-ethanodibenzo[b,f][1,5]-diazocine (ethano-Tröger's base) with methyl iodide followed by ion metathesis and fluorination with N-fluoro-2,3,4,5,6-pentachloropyridinium triflate affords a new electrophilic N-F reagent, that is more reactive than Selectfluor. 2D (19)F-(15)N HMQC experiments provide (1)JNF coupling constants which are diagnostic for the N-F functional group.
authors.affiliation: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, OX1 3TA Oxford, UK. veronique.gouverneur@chem.ox.ac.uk.
authors.forename: Raul
authors.initials: R
authors.lastname: Pereira
authors.forename: Jamie
authors.initials: J
authors.lastname: Wolstenhulme
authors.forename: Graham
authors.initials: G
authors.lastname: Sandford
authors.forename: Timothy D W
authors.initials: TD
authors.lastname: Claridge
authors.forename: Véronique
authors.initials: V
authors.lastname: Gouverneur
authors.forename: Ján
authors.initials: J
authors.lastname: Cvengroš