title: Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population.
abstract: Osteosarcoma is one of the most common bone malignancies in adolescents, and hereditary factors may influence its susceptibility. We assessed the association between XRCC3 Thr241Met polymorphism and susceptibility to osteosarcoma in a Chinese population. Between May 2012 and May 2014, a total of 136 osteosarcoma patients and 136 healthy control subjects were included in our study. The XRCC3 Thr241Met polymorphism was analyzed using a polymerase chain reaction restriction fragment length polymorphism assay. By multiple logistic regression analysis, individuals carrying the Met/Met genotype of XRCC3 Thr241Met were at significantly increased risk of osteosarcoma when compared with the Thr/Thr (OR = 2.50, 95%CI = 1.13-5.66). The Thr/Met+Met/Met genotype of XRCC3 Thr241Met was furthermore found to be correlated with an elevated increased risk of osteosarcoma when compared with the Thr/Thr genotype (OR = 1.71, 95%CI = 1.03-2.87), and Met/Met genotype of XRCC3 Thr241Met was associated with an increased risk of osteosarcoma compared to the Thr/Thr (OR = 3.50, 95%CI = 1.51-8.79). In conclusion, our study firstly reports that XRCC3 Thr241Met gene polymorphism is associated with an elavated risk of osteosarcoma.
authors.affiliation: The Second Hospital of Inner Mongolia Medical University, Hohhot, China.
authors.forename: J
authors.initials: J
authors.lastname: Guo
authors.affiliation: The Second Hospital of Inner Mongolia Medical University, Hohhot, China.
authors.forename: H C
authors.initials: HC
authors.lastname: Lv
authors.affiliation: International Mongolian Medicine Hospital of Inner Mongolia, Hohhot, China.
authors.forename: R H
authors.initials: RH
authors.lastname: Shi
authors.affiliation: The Second Hospital of Inner Mongolia Medical University, Hohhot, China.
authors.forename: W L
authors.initials: WL
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics; D001859:Bone Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002681:China; D003062:Codon; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D016017:Odds Ratio; D012516:Osteosarcoma / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D055815:Young Adult
chemical_list: D003062:Codon; D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3