title: A palm-sized high-sensitivity near-infrared fluorescence imager for laparotomy surgery.
abstract: In laparotomy surgery guided by near-infrared fluorescence imaging, the access to the field of operation is limited by the illumination and/or the imaging field. The side of cavities or organs such as the liver or the heart cannot be examined with the systems available on the market, which are too large and too heavy. In this article, we describe and evaluate a palm sized probe, whose properties, weight, size and sensitivity are adapted for guiding laparotomy surgery. Different experiments have been performed to determine its main characteristics, both on the illumination and imaging sides. The device has been tested for fluorescent molecular probe imaging in preclinical procedures, to prove its ability to be used in cancer nodule detection during surgery. This system is now CE certified for clinical procedures and Indocyanine Green imaging has been performed during clinical investigations: lymphedema and surgical resection of liver metastases of colorectal cancers.
authors.affiliation: Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie, UMR 7357, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg/CNRS, 67412 Illkirch, France; Fluoptics, 38040 Grenoble, France. Electronic address: paul.dorval@live.fr.
authors.forename: Paul
authors.initials: P
authors.lastname: Dorval
authors.affiliation: Fluoptics, 38040 Grenoble, France.
authors.forename: Norman
authors.initials: N
authors.lastname: Mangeret
authors.affiliation: Fluoptics, 38040 Grenoble, France.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Guillermet
authors.affiliation: Institut Albert Bonniot, U-823, Université Joseph Fourier/INSERM, 38000 Grenoble, France.
authors.forename: Ihab
authors.initials: I
authors.lastname: Atallah
authors.affiliation: Institut Albert Bonniot, U-823, Université Joseph Fourier/INSERM, 38000 Grenoble, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Righini
authors.affiliation: Centre Hospilato-Universitaire de Saint-Etienne, 42000 Saint-Etienne, France. Electronic address: gabriele.barabino@chu-st-etienne.fr.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Barabino
authors.affiliation: Institut Albert Bonniot, U-823, Université Joseph Fourier/INSERM, 38000 Grenoble, France. Electronic address: jean-luc.coll@ujf-grenoble.fr.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Coll
authors.affiliation: Fluoptics, 38040 Grenoble, France; CEA-LETI, Minatec, 38054 Grenoble, France. Electronic address: philippe.rizo@fluoptics.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Rizo
authors.affiliation: Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie, UMR 7357, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg/CNRS, 67412 Illkirch, France. Electronic address: p.poulet@unistra.fr.
authors.forename: Patrick
authors.initials: P
authors.lastname: Poulet
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design; D005260:Female; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D006498:Hepatectomy; D006801:Humans; D007208:Indocyanine Green / Q000737:chemistry; D007813:Laparotomy / Q000295:instrumentation* / Q000379:methods; D057230:Limit of Detection; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D008209:Lymphedema / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D051379:Mice; D008819:Mice, Nude; D008904:Miniaturization; D009368:Neoplasm Transplantation; D055100:Optical Fibers; D011108:Polymers / Q000737:chemistry; D015203:Reproducibility of Results; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D025321:Surgery, Computer-Assisted / Q000295:instrumentation*
chemical_list: D005456:Fluorescent Dyes; D011108:Polymers; D007208:Indocyanine Green
keywords: Fluorescence image-guided surgery; Indocyanine green; Molecular imaging; Near-infrared fluorescence