title: Sendai virus as a backbone for vaccines against RSV and other human paramyxoviruses.
abstract: Human paramyxoviruses are the etiological agents for life-threatening respiratory virus infections of infants and young children. These viruses, including respiratory syncytial virus (RSV), the human parainfluenza viruses (hPIV1-4) and human metapneumovirus (hMPV), are responsible for millions of serious lower respiratory tract infections each year worldwide. There are currently no standard treatments and no licensed vaccines for any of these pathogens. Here we review research with which Sendai virus, a mouse parainfluenza virus type 1, is being advanced as a Jennerian vaccine for hPIV1 and as a backbone for RSV, hMPV and other hPIV vaccines for children.
authors.affiliation: a Department of Infectious Diseases , St. Jude Children's Research Hospital , Memphis , TN , USA.|b Department of Microbiology, Immunology and Biochemistry , University of Tennessee Health Science Center , Memphis , TN , USA.
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Russell
authors.affiliation: a Department of Infectious Diseases , St. Jude Children's Research Hospital , Memphis , TN , USA.|b Department of Microbiology, Immunology and Biochemistry , University of Tennessee Health Science Center , Memphis , TN , USA.
authors.forename: Julia L
authors.initials: JL
authors.lastname: Hurwitz
mesh_terms: D000818:Animals; D004337:Drug Carriers; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D005822:Genetic Vectors; D006801:Humans; D018184:Paramyxoviridae Infections / Q000517:prevention & control; D018357:Respiratory Syncytial Virus Infections / Q000517:prevention & control; D010253:Respirovirus Infections / Q000517:prevention & control*; D029082:Sendai virus / Q000235:genetics*; D014765:Viral Vaccines / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification*
chemical_list: D004337:Drug Carriers; D014765:Viral Vaccines
keywords: Sendai virus; T cell; antibody; intranasal; paramyxovirus; pediatric vaccine; respiratory tract; vaccine vector