title: N-Acetyltransferase 2 Genotypes Are Associated With Diisocyanate-Induced Asthma.
abstract: OBJECTIVE
  To investigate whether genetic variants of N-acetyltransferase (NAT) genes are associated with diisocyanate asthma (DA).
  
  
  METHODS
  The study population consisted of 354 diisocyanate-exposed workers. Genotyping was performed using a 5'-nuclease polymerase chain reaction assay.
  
  
  RESULTS
  The NAT2 rs2410556 and NAT2 rs4271002 variants were significantly associated with DA in the univariate analysis. In the first logistic regression model comparing DA+ and asymptomatic worker groups, the rs2410556 (P = 0.004) and rs4271002 (P < 0.001) single nucleotide polymorphisms and the genotype combination, NAT2 rs4271002*NAT1 rs11777998, showed associations with DA risk (P = 0.014). In the second model comparing DA+ and DA- groups, NAT2 rs4271002 variant and the combined genotype, NAT1 rs8190845*NAT2 rs13277605, were significantly associated with DA risk (P = 0.022, P = 0.036, respectively).
  
  
  CONCLUSIONS
  These findings suggest that variations in the NAT2 gene and their interactions contribute to DA susceptibility.
authors.affiliation: Division of Immunology, Allergy and Rheumatology (Drs Yucesoy, Lummus, and Bernstein), University of Cincinnati, Ohio; NIEHS/NIH (Dr Kissling), Research Triangle Park; BRT-Burleson Research Technologies (Dr Johnson), Morrisville, North Carolina; Hôpital du Sacré-Coeur de Montréal (Drs Gautrin and Cartier), Université de Montréal, Montreal, Quebec; Hôpital Laval (Dr Boulet), Université Laval, Sainte-Foy, Québec, Canada; Department of Allergy (Dr Sastre), Fundación Jiménez Díaz and CIBER de Enfermedades Respiratorias CIBERES; Department of Allergy (Dr Quirce), Hospital La Paz-IdiPAZ and CIBER de Enfermedades Respiratorias CIBERES, Madrid, Spain; Department of Medicine and Dalla Lana School of Public Health (Dr Tarlo), University of Toronto, Ontario, Canada; Hospitals Vall D'Hebron (Drs Cruz and Munoz), Barcelona and CIBER de Enfermedades Respiratorias CIBERES, Madrid, Spain; and School of Public Health (Dr Luster), West Virginia University, Morgantown.
authors.forename: Berran
authors.initials: B
authors.lastname: Yucesoy
authors.forename: Grace E
authors.initials: GE
authors.lastname: Kissling
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Johnson
authors.forename: Zana L
authors.initials: ZL
authors.lastname: Lummus
authors.forename: Denyse
authors.initials: D
authors.lastname: Gautrin
authors.forename: André
authors.initials: A
authors.lastname: Cartier
authors.forename: Louis-Philippe
authors.initials: LP
authors.lastname: Boulet
authors.forename: Joaquin
authors.initials: J
authors.lastname: Sastre
authors.forename: Santiago
authors.initials: S
authors.lastname: Quirce
authors.forename: Susan M
authors.initials: SM
authors.lastname: Tarlo
authors.forename: Maria-Jesus
authors.initials: MJ
authors.lastname: Cruz
authors.forename: Xavier
authors.initials: X
authors.lastname: Munoz
authors.forename: Michael I
authors.initials: MI
authors.lastname: Luster
authors.forename: David I
authors.initials: DI
authors.lastname: Bernstein
mesh_terms: D000328:Adult; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D059366:Asthma, Occupational / Q000139:chemically induced* / Q000235:genetics; D002170:Canada; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D017953:Isocyanates / Q000633:toxicity*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013030:Spain
chemical_list: D004785:Environmental Pollutants; D005819:Genetic Markers; D017953:Isocyanates; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human