title: [Biosynthesis-based production improvement and structure modification of erythromycin A].
abstract: Erythromycin A is a clinically important macrolide antibiotic with broad-spectrum activity. Its biosynthesis involves the formation of the 14-membered skeleton catalyzed by polyketide synthases, and the modification steps such as hydroxylation, glycosylation and methylation. Based on the understanding of the biosynthetic mechanism, it is reliable to genetically manipulate the erythromycin A-producing strain for production improvement and structure modification. In this paper, we reviewed the progress regarding erythromycin A in high-producing strain construction and chemical structure derivation, to provide insights for further development.
authors.forename: Dandan
authors.initials: D
authors.lastname: Chen
authors.forename: Jiequn
authors.initials: J
authors.lastname: Wu
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry*; D004917:Erythromycin / Q000096:biosynthesis* / Q000737:chemistry*; D006031:Glycosylation; D006900:Hydroxylation; D008745:Methylation; D005810:Multigene Family; D048630:Polyketide Synthases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin; D048630:Polyketide Synthases