title: Six Minute Walk Distance and Reference Equations in Normal Healthy Subjects of Nepal.
abstract: BACKGROUND
  The self-paced six minute walk test is a simple assessment for sub-maximal functional capacity. It correlates well with sophisticated tests and gives good prediction for morbidity, mortality, quality of life and pulmonary functions.
  
  
  OBJECTIVE
  To evaluate six minute walk distance in healthy adults to identify reference values and formulate reference equations.
  
  
  METHODS
  We conducted six minute walk test on 250 random volunteers at and above 18 years of age as per standard protocol. Age, gender, height and weight were measured. Pretest and post-test vital parameters were recorded including pulse oximetry. The six minute walking distance was identified in all subjects. Multiple regression analysis was done to formulate regression equations to predict six minute walking distance. This also correlated age, gender, height, weight, body mass index with six minute walking distance.
  
  
  RESULTS
  The mean six minute walking distance was 489±86 meters with males walking 509±82 meters and females 445±78 meters. Age, gender, weight and body mass index had significant contribution for prediction of six minute walking distance. Gender was the single most important predictor. Height had the least significance. Depending on coefficients of these variables we formulated three regression equations and tested them for accurate prediction. The two best equations were identified as: Predicted SMWD = 395-1.5xAge+2.47xWT-35.89xGender and Predicted SMWD = 440-1.82xAge-53.07xGender+5.12xBMI.
  
  
  CONCLUSIONS
  Gender, age and height are the most important predictors of six minute walking distance. Reference values and equations for both genders, different age groups with varying weights were derived for local population.
authors.affiliation: National Academy of Medical Sciences Bir Hospital, Kathmandu, Nepal.
authors.forename: S K
authors.initials: SK
authors.lastname: Shrestha
authors.affiliation: National Academy of Medical Sciences Bir Hospital, Kathmandu, Nepal.
authors.forename: B
authors.initials: B
authors.lastname: Srivastava
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D001835:Body Weight; D005080:Exercise Test / Q000379:methods* / Q000592:standards*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D009390:Nepal; D010092:Oximetry; D011788:Quality of Life; D012016:Reference Values; D012737:Sex Factors; D055986:Vital Signs; D016138:Walking; D055815:Young Adult