title: Identification and Characterization of FTY720 for the Treatment of Human African Trypanosomiasis.
abstract: The screening of a focused library identified FTY720 (Fingolimod; Gilenya) as a potent selective antitrypanosomal compound active against Trypanosoma brucei gambiense and T. brucei rhodesiense, the causative agents of human African trypanosomiasis (HAT). This is the first report of trypanocidal activity for FTY720, an oral drug registered for the treatment of relapsing multiple sclerosis, and the characterization of sphingolipids as a potential new class of compounds for HAT.
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Queensland, Australia a.jones@griffith.edu.au.
authors.forename: Amy J
authors.initials: AJ
authors.lastname: Jones
authors.affiliation: Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland.
authors.forename: Marcel
authors.initials: M
authors.lastname: Kaiser
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Queensland, Australia.
authors.forename: Vicky M
authors.initials: VM
authors.lastname: Avery
mesh_terms: D002460:Cell Line; D000068876:Fingolimod Hydrochloride / Q000627:therapeutic use*; D057809:HEK293 Cells; D006801:Humans; D021261:Parasitic Sensitivity Tests; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014346:Trypanosoma brucei brucei / Q000187:drug effects*; D014347:Trypanosoma brucei gambiense / Q000187:drug effects*; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects*; D014353:Trypanosomiasis, African / Q000188:drug therapy*
chemical_list: D014344:Trypanocidal Agents; D000068876:Fingolimod Hydrochloride