title: Abscopal Effects and Yttrium-90 Radioembolization.
abstract: We present the case of an 80-year-old male with squamous cell carcinoma with bilobar hepatic metastases who underwent targeted Yttrium-90 radioembolization of the right hepatic lobe lesion. Subsequently, there was complete regression of the nontargeted, left hepatic lobe lesion. This may represent the first ever reported abscopal effect in radioembolization. The abscopal effect refers to the phenomenon of tumor response in nontargeted sites after targeted radiotherapy. In this article, we briefly review the immune-mediated mechanisms responsible for the abscopal effect.
authors.affiliation: Department of Radiology, University Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Anish
authors.initials: A
authors.lastname: Ghodadra
authors.affiliation: Department of Radiology, University Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Sumantha
authors.initials: S
authors.lastname: Bhatt
authors.affiliation: Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Camacho
authors.affiliation: Department of Radiology, University Pittsburgh School of Medicine, Pittsburgh, PA, USA. kevin.kim@yale.edu.|Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA. kevin.kim@yale.edu.|Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale Cancer Center, Yale School of Medicine, Yale University, 330 Cedar Street, TE 2-224, New Haven, CT, 06510, USA. kevin.kim@yale.edu.
authors.forename: Hyun S
authors.initials: HS
authors.lastname: Kim
mesh_terms: D000369:Aged, 80 and over; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary*; D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary*; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D064847:Multimodal Imaging; D009365:Neoplasm Regression, Spontaneous; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000532:radiotherapy*; D010166:Palliative Care; D047368:Tumor Burden; D015021:Yttrium Radioisotopes / Q000627:therapeutic use
chemical_list: D015021:Yttrium Radioisotopes
keywords: Hepatic; Interventional oncology; Liver; Neoplasm; Radioembolization; Tumor