title: [Analysis on the prognosis of malignant transformation of sinonasal inverted papilloma].
abstract: OBJECTIVE
  To summarize the clinical characteristics and treatments of patients with malignant transformation of sinonasal inverted papilloma (SNIP), and to explore the factors influencing the prognosis of malignant SNIP.
  
  
  METHODS
  To retrospectively analyze the clinical data of 35 patients with malignant SNIP. The prognosis affected by age, gender, pathogenetic locations, pathology, clinical stages and treatments were analysed using Kaplan Meier, Log rank and Cox method.
  
  
  RESULTS
  In our research, 5 years survival rate was 68.6% in malignant SNIP. There were 3 factors effecting the 5 years survival rate of malignant SNIP: clinical staging, histopathological features and treatments while gender, age, disease location, and percentage of the malignant cell in the entire tumor tissue had no effect on overall survival rate. Clinical staging and treatment were the independent factors that influenced the prognosis of malignant SNIP (P value was 0.019 and 0.006).
  
  
  CONCLUSIONS
  Risk factors that independently influence the survival of patients with malignant SNIP were the clinical staging and treatment. The degree of histo pathological features can be the secondary indicator to judge the prognosis of malignant SNIP. Endoscopic surgery or comprehensive therapy performed on patients properly is therapeutically effective.
authors.forename: Xing
authors.initials: X
authors.lastname: Lu
authors.forename: Huanxin
authors.initials: H
authors.lastname: Yu
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
mesh_terms: D002471:Cell Transformation, Neoplastic; D004724:Endoscopy; D006801:Humans; D009669:Nose Neoplasms / Q000175:diagnosis / Q000473:pathology*; D018308:Papilloma, Inverted / Q000175:diagnosis / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate