title: Construction of novel sensitive electrochemical sensor for electro-oxidation and determination of citalopram based on zinc oxide nanoparticles and multi-walled carbon nanotubes.
abstract: A new chemically modified carbon paste electrode (CMCPE) was applied to the simple, rapid, highly selective and sensitive determination of citalopram in human serum and pharmaceutical preparations using adsorptive square wave voltammetry (ASWV). The ZnO nanoparticles and multi-walled carbon nanotubes modified CPE (ZnO-MWCNT/CPE) electrode was prepared by incorporation of the ZnO nanoparticles and multi-walled carbon nanotubes (MWCNT) in carbon paste electrode. The limit of detection and the linear range were found to be 0.005 and 0.012 to 1.54μmolL(-1) of citalopram, respectively. The effects of potentially interfering substances on the determination of this compound were investigated and found that the electrode is highly selective. The proposed CMCPE was used to the determination of citalopram in human serum, urine and pharmaceutical samples. This reveals that ZnO-MWCNT/CPE shows excellent analytical performance for the determination of citalopram in terms of very low detection limit, high sensitivity, very good repeatability and reproducibility over other methods reported in the literature.
authors.affiliation: Faculty of Engineering, Bushehr Branch, Islamic Azad University, Bushehr, Iran. Electronic address: hamedghaedi@gmail.com.
authors.forename: Hamed
authors.initials: H
authors.lastname: Ghaedi
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Afkhami
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
authors.forename: Tayyebeh
authors.initials: T
authors.lastname: Madrakian
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Soltani-Felehgari
mesh_terms: D015283:Citalopram / Q000032:analysis*; D055664:Electrochemical Techniques / Q000379:methods*; D006801:Humans; D037742:Nanotubes, Carbon / Q000737:chemistry*; D012680:Sensitivity and Specificity; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D037742:Nanotubes, Carbon; D015283:Citalopram; D015034:Zinc Oxide
keywords: Chemically modified electrode; Citalopram determination; Electrochemical sensor; Human serum; Pharmaceutical preparations; Square wave voltammetry