title: Permanent interstitial 125I seed implantation as a salvage therapy for pediatric recurrent or metastatic soft tissue sarcoma after multidisciplinary treatment.
abstract: BACKGROUND
  The management of pediatric recurrent or metastatic soft tissue sarcoma after multimodal treatment remains challenging. We investigated the feasibility, efficacy, and morbidity of permanent interstitial (125)I seed implantation under image guidance as a salvage treatment for pediatric patients with recurrent or metastatic soft tissue sarcoma.
  
  
  METHODS
  This was a retrospective study of 10 patients who underwent percutaneous ultrasound or computed tomography (CT) guided permanent (125)I seed implantation. Postoperative dosimetry was performed for all patients. Actuarial D90 was 121-187.1 Gy (median, 170.3 Gy). The number of (125)I seeds implanted was 6-158 (median, 34.5), with a median specific activity of 0.7 mCi per seed (range, 0.62-0.8 mCi); total activity was 4.2-113.76 mCi. Follow-up time was 6-107 months (median, 27.5 months); no patients were lost to follow-up.
  
  
  RESULTS
  The overall response rate (complete response + partial response) was 8/10 (80 %), including two patients with complete response (CR) (20 %) and five patients with partial response (PR) (60 %). Local control rates after 1 and 2 years were 70.1 and 62.3 %, respectively, with a mean local control time of 70.6 months (95 % confidence interval (CI) 45.1-96.0). Survival rates after 1 and 2 years were 68.6 and 57.1 %, respectively, with a mean survival time of 65.3 months (95 % CI 34.1-96.5). Three patients died from distant metastasis; one died from local recurrence 12 months after seed implantation. Three patients suffered a grade I skin reaction and one developed ulceration. No severe adverse neurologic sequelae or blood vessel damage occurred.
  
  
  CONCLUSIONS
  Image guided permanent interstitial (125)I seed implantation as a salvage treatment appears to have a satisfactory outcome in children with recurrent or metastatic soft tissue sarcoma.
authors.affiliation: Department of Radiation Oncology, Peking University Third Hospital, Hua-yuan North Road No.49, Beijing, 100191, People's Republic of China. yaolihong133@sina.com.
authors.forename: Lihong
authors.initials: L
authors.lastname: Yao
authors.affiliation: Department of Radiation Oncology, Peking University Third Hospital, Hua-yuan North Road No.49, Beijing, 100191, People's Republic of China. junjiewang_edu@sina.cn.
authors.forename: Junjie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Peking University Third Hospital, Hua-yuan North Road No.49, Beijing, 100191, People's Republic of China. radiotherapy@sina.com.
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Radiation Oncology, Peking University Third Hospital, Hua-yuan North Road No.49, Beijing, 100191, People's Republic of China. ljnbmu956@aliyun.com.
authors.forename: Jinna
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Peking University Third Hospital, Hua-yuan North Road No.49, Beijing, 100191, People's Republic of China. linl2007@foxmail.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Lin
authors.affiliation: Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, People's Republic of China. ranwq-sina@vip.sina.com.
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Ran
authors.affiliation: Department of Radiology, Peking University Third Hospital, Beijing, 100191, People's Republic of China. doctorliuchen@163.com.
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D001918:Brachytherapy; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D012189:Retrospective Studies; D016879:Salvage Therapy; D012509:Sarcoma / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes