title: Is inflammatory bowel disease in dogs and cats associated with a Th1 or Th2 polarization?
abstract: Mucosal immunity involves complex interactions to generate either immune tolerance or active immune responses. An imbalance of pro- and anti-inflammatory cytokines and chemokines that drive the recruitment of immune cells to the intestinal mucosa are a key characteristic of inflammatory bowel disease in humans, where distinctive helper-T-lymphocyte profiles help to discriminate between Crohn's disease and ulcerative colitis. This review evaluates the current veterinary literature to determine whether a Th1/Th2 (and possibly also Th17) polarization also exists in canine and feline inflammatory bowel disease.
authors.affiliation: Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, USA. Electronic address: rheilmann@cvm.tamu.edu.
authors.forename: Romy M
authors.initials: RM
authors.lastname: Heilmann
authors.affiliation: Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, USA.
authors.forename: Jan S
authors.initials: JS
authors.lastname: Suchodolski
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000276:immunology*; D002415:Cats; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000662:veterinary*; D018417:Th1 Cells / Q000502:physiology*; D058504:Th17 Cells / Q000502:physiology; D018418:Th2 Cells / Q000502:physiology*
keywords: Canine; Chronic enteropathy; Inflammatory bowel disease; Th1; Th17; Th2