title: Acetogenins from Annonaceae.
abstract: In recent decades, annonaceous acetogenins have become highly studied plant secondary metabolites in terms of their isolation, structure elucidation, synthesis, biological evaluation, mechanism of action, and toxicity. The aim of the present contribution is to summarize chemical and biological reports published since 1997 on annonaceous acetogenins and synthetic acetogenin mimics. The compounds are considered biologically in terms of their cytotoxicity for cancer cell lines, neurotoxicity, pesticidal effects, and miscellaneous activities.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, 804, Taiwan. ccliaw@mail.nsysu.edu.tw.
authors.forename: Chih-Chuang
authors.initials: CC
authors.lastname: Liaw
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. liu740122@gmail.com.
authors.forename: Jing-Ru
authors.initials: JR
authors.lastname: Liou
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. u96831003@kmu.edu.tw.
authors.forename: Tung-Ying
authors.initials: TY
authors.lastname: Wu
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. aaronfrc@kmu.edu.tw.
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.affiliation: School of Pharmacy, College of Pharmacy, China Medical University, Taichung, 404, Taiwan. yachwu@mail.cmu.edu.tw.
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D054378:Acetogenins / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D029061:Annonaceae / Q000737:chemistry* / Q000145:classification; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D054378:Acetogenins; D010936:Plant Extracts
keywords: Acetogenin mimics; Acetogenins; Annonaceae; Anti-cancer activity; Apoptosis; Atypical Parkinsonism; Ionophores; Mitochondria complex I inhibition; Neurotoxicity; Pesticidal activity