title: Multifaceted and route-controlled "click" reactions based on vapor-deposited coatings.
abstract: "Click" reactions provide precise and reliable chemical transformations for the preparation of functional architectures for biomaterials and biointerfaces. The emergence of a multiple-click reaction strategy has paved the way for a multifunctional microenvironment with orthogonality and precise multitasking that mimics nature. We demonstrate a multifaceted and route-controlled click interface using vapor-deposited functionalized poly-para-xylylenes. Distinctly clickable moieties of ethynyl and maleimide were introduced into poly-para-xylylenes in one step via a chemical vapor deposition (CVD) copolymerization process. The advanced interface coating allows for a double-click route with concurrent copper(i)-catalyzed Huisgen 1,3-dipolar cycloaddition (CuAAC) and the thiol-maleimide click reaction. Additionally, double-click reactions can also be performed in a cascade manner by controlling the initiation route to enable the CuAAC and/or thiol-yne reaction using a mono-functional alkyne-functionalized poly-para-xylylene. The use of multifaceted coatings to create straightforward and orthogonal interface properties with respect to protein adsorption and cell attachment is demonstrated and characterized.
authors.affiliation: Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan. hsychen@ntu.edu.tw.
authors.forename: Ting-Pi
authors.initials: TP
authors.lastname: Sun
authors.affiliation: Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan. hsychen@ntu.edu.tw.
authors.forename: Ching-Heng
authors.initials: CH
authors.lastname: Tai
authors.affiliation: Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan. hsychen@ntu.edu.tw.
authors.forename: Jyun-Ting
authors.initials: JT
authors.lastname: Wu
authors.affiliation: Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan. hsychen@ntu.edu.tw.
authors.forename: Chih-Yu
authors.initials: CY
authors.lastname: Wu
authors.affiliation: Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan. hsychen@ntu.edu.tw.
authors.forename: Wei-Chieh
authors.initials: WC
authors.lastname: Liang
authors.affiliation: Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan. hsychen@ntu.edu.tw.
authors.forename: Hsien-Yeh
authors.initials: HY
authors.lastname: Chen
mesh_terms: D000327:Adsorption; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D057930:Click Chemistry; D008301:Maleimides / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties; D055548:Vapor Pressure; D014992:Xylenes / Q000737:chemistry*
chemical_list: D000480:Alkynes; D008301:Maleimides; D011108:Polymers; D014992:Xylenes; C043592:maleimide