title: Exposure to bisphenol A and behavior in school-age children.
abstract: BACKGROUND
  Bisphenol A (BPA) exposure has been shown to affect human brain neurodevelopment and behavior.
  
  
  OBJECTIVE
  We aimed to investigate whether environmental exposure to BPA in children was associated with their childhood behavior.
  
  
  METHODS
  Urinary BPA concentrations and behavioral characteristics were assessed in 300 children belonging to the INMA "Environment and Childhood" Granada birth cohort in their follow-up at 9-11 years of age. BPA concentrations were quantified in urine using liquid chromatography-tandem mass spectrometry (LC-MS-MS), and child behavior reported by parents using the Child Behavior Checklist (CBCL/6-18) under supervision of a psychologist. The association between BPA concentrations and CBCL standardized scores was analyzed using linear regression models, adjusted for important covariates.
  
  
  RESULTS
  Median (P25, P75) BPA concentration was 4.76 (2.77, 9.03)μg/L. Mean (±SD) CBCL externalizing and internalizing scores were 56.35 (±8.06) and 51.36 (±9.22), respectively. In multivariate regression analyses, adjusted for maternal and child characteristics, higher BPA concentrations were associated with worse behavioral scores on all scales. Children with BPA concentrations in the 4th quartile had more somatic complaints (β=2.35; 95% CI: 0.25, 4.46) and social (β=1.71; 95% CI: 0.19, 3.22) and thought problems (β=2.58; 95% CI: 0.66, 4.51) in comparison to those in the 1st quartile. Children with values in the 3rd quartile of BPA concentrations also showed greater social problems (β=1.94; 95% CI: 0.43, 3.45).
  
  
  CONCLUSIONS
  Our results suggest that exposure to BPA in childhood may affect children's behavior. Although further investigations are required, preventive measures should be undertaken to reduce inadvertent exposure to BPA.
authors.affiliation: Instituto de Investigación Biosanitaria ibs.GRANADA, University of Granada, Av. Madrid s/n, Granada 18071, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Perez-Lobato
authors.affiliation: Instituto de Investigación Biosanitaria ibs.GRANADA, University of Granada, Av. Madrid s/n, Granada 18071, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Mustieles
authors.affiliation: Instituto de Investigación Biosanitaria ibs.GRANADA, University of Granada, Av. Madrid s/n, Granada 18071, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Calvente
authors.affiliation: Instituto de Investigación Biosanitaria ibs.GRANADA, University of Granada, Av. Madrid s/n, Granada 18071, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Jimenez-Diaz
authors.affiliation: Instituto de Investigación Biosanitaria ibs.GRANADA, University of Granada, Av. Madrid s/n, Granada 18071, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Ramos
authors.affiliation: University of Córdoba, Institute of Fine Chemistry and Nanochemistry, 14017 Córdoba, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Caballero-Casero
authors.affiliation: University of Córdoba, Institute of Fine Chemistry and Nanochemistry, 14017 Córdoba, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: López-Jiménez
authors.affiliation: University of Córdoba, Institute of Fine Chemistry and Nanochemistry, 14017 Córdoba, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Rubio
authors.affiliation: Instituto de Investigación Biosanitaria ibs.GRANADA, University of Granada, Av. Madrid s/n, Granada 18071, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Olea
authors.affiliation: Instituto de Investigación Biosanitaria ibs.GRANADA, University of Granada, Av. Madrid s/n, Granada 18071, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Electronic address: marieta@ugr.es.
authors.forename: M F
authors.initials: MF
authors.lastname: Fernandez
mesh_terms: D001559:Benzhydryl Compounds / Q000633:toxicity* / Q000652:urine; D057189:Checklist; D002648:Child; D002653:Child Behavior Disorders / Q000453:epidemiology* / Q000652:urine*; D002853:Chromatography, Liquid; D015331:Cohort Studies; D018672:Community Health Planning; D004785:Environmental Pollutants / Q000633:toxicity* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D019964:Mood Disorders / Q000453:epidemiology* / Q000652:urine*; D010636:Phenols / Q000633:toxicity* / Q000652:urine; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: BPA exposure; Birth cohort; Cognitive and behavior functioning; Healthy children