title: Changes in Membrane Receptors and Ion Channels as Potential Biomarkers for Osteoarthritis.
abstract: Osteoarthritis (OA), a degenerative joint condition, is currently difficult to detect early enough for any of the current treatment options to be completely successful. Early diagnosis of this disease could increase the numbers of patients who are able to slow its progression. There are now several diseases where membrane protein biomarkers are used for early diagnosis. The numbers of proteins in the membrane is vast and so it is a rich source of potential biomarkers for OA but we need more knowledge of these before they can be considered practical biomarkers. How are they best measured and are they selective to OA or even certain types of OA? The first step in this process is to identify membrane proteins that change in OA. Here, we summarize several ion channels and receptors that change in OA models and/or OA patients, and may thus be considered candidates as novel membrane biomarkers of OA.
authors.affiliation: Faculty of Health and Medical Sciences, School of Veterinary Medicine and Science, University of Surrey Guildford, UK.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Lewis
authors.affiliation: Department of Musculoskeletal Biology, Faculty of Health and Life Sciences, Institute of Ageing and Chronic Disease, University of Liverpool Liverpool, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: Barrett-Jolley
keywords: biomarkers; cartilage; chondrocytes; ion channels; osteoarthritis