title: Demographic and clinical characteristics of patients with type 1 diabetes mellitus: A multicenter registry study in Guangdong, China.
abstract: BACKGROUND
  A lack of demographic and clinical data hinders efforts of health care providers in China to support patients with type 1 diabetes mellitus (T1D). Therefore, the aim of the present retrospective study was to provide an overview of the demographic and clinical characteristics of Chinese patients with T1D.
  
  
  METHODS
  Hospital medical records of patients with T1D (diagnosed between January 2000 and December 2011) in 105 secondary and tertiary hospitals across Guangdong province were reviewed. Data were collected on patient age at diagnosis, presentations at onset, physical examination, and diabetes management.
  
  
  RESULTS
  In all, 3173 patients diagnosed with T1D between January 2000 and December 2011 were included in the study (46.2% female). The median age at diagnosis was 27.5 years (interquartile range [IQR] 18.0-38.0) years and the median body mass index (BMI) at onset was 19.6 kg/m2(IQR 17.4-21.8 kg/m2). Among adult patients, 0.9% were obese, 6.6% were overweight, 62.3% were normal weight, and 30.3 % were underweight. The prevalence of diabetic ketoacidosis (DKA) at onset was 50.1%. The proportion of patients with retinopathy, nephropathy, and neuropathy was 8.1%, 20.7 %, and 11.1%, respectively.
  
  
  CONCLUSIONS
  The adult-onset form of T1D is not rare in China. The registry participants were characterized by older age at onset, lower BMI, and a higher prevalence of DKA at onset compared with those in regions with a high incidence of T1D, such as northern Europe. These findings contribute to a better understanding of the heterogeneity of T1D in different populations and so will help healthcare providers to develop management models that are more suitable for these patients.
authors.affiliation: Department of Endocrinology & Metabolic Disease, The 3rd Affiliated Hospital of Sun Yat-sen University.|Guangdong Diabetes Center, Guangzhou.
authors.forename: Daizhi
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Endocrinology & Metabolic Disease, The 3rd Affiliated Hospital of Sun Yat-sen University.|Guangdong Diabetes Center, Guangzhou.
authors.forename: Hongrong
authors.initials: H
authors.lastname: Deng
authors.affiliation: The 1st Affiliated Hospital of Shenzhen University, Shenzen.
authors.forename: Guochun
authors.initials: G
authors.lastname: Luo
authors.affiliation: Affiliated Hospital of Guangdong Medical College, Zhanjiang.
authors.forename: Ge
authors.initials: G
authors.lastname: Wu
authors.affiliation: The 1st Affiliated Hospital of Shantou University Medical College, Shantou.
authors.forename: Shaoda
authors.initials: S
authors.lastname: Lin
authors.affiliation: Zhuhai People's Hospital, Zhuhai.
authors.forename: Lin
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Huizhou Municipal Central Hosptial, Huizhou.
authors.forename: Meilun
authors.initials: M
authors.lastname: Xv
authors.affiliation: Qingyuan People's Hospital, Qingyuan.
authors.forename: Shaoqing
authors.initials: S
authors.lastname: Li
authors.affiliation: Dongguan People's Hospital, Dongguan.
authors.forename: Xiuwei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Yue Bei People's Hospital, Shaoguan.
authors.forename: Jianneng
authors.initials: J
authors.lastname: Wu
authors.affiliation: Foshan Hospital of Traditional Chinese Medicine, Foshan.
authors.forename: Jiangming
authors.initials: J
authors.lastname: Lang
authors.affiliation: Zhongshan People's Hospital, Zhongshan.
authors.forename: Ganxiong
authors.initials: G
authors.lastname: Liang
authors.affiliation: Jiangmen Central Hospital, Jiangmen.
authors.forename: Jiancai
authors.initials: J
authors.lastname: Lin
authors.affiliation: Guangzhou 1st Municipal People's Hospital, Guangzhou.
authors.forename: Dingyu
authors.initials: D
authors.lastname: Chen
authors.affiliation: Shenzhen People's Hospital, Shenzhen.
authors.forename: Lu
authors.initials: L
authors.lastname: Li
authors.affiliation: Jieyang People's Hospital, Jieyang.
authors.forename: Yishan
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Meizhou People's Hospital, Meizhou.
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Maoming People's Hospital, Maoming, China.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Ou
authors.affiliation: Department of Endocrinology & Metabolic Disease, The 3rd Affiliated Hospital of Sun Yat-sen University.|Guangdong Diabetes Center, Guangzhou.
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Endocrinology & Metabolic Disease, The 3rd Affiliated Hospital of Sun Yat-sen University.|Guangdong Diabetes Center, Guangzhou.
authors.forename: Jianping
authors.initials: J
authors.lastname: Weng
authors.affiliation: Department of Endocrinology & Metabolic Disease, The 3rd Affiliated Hospital of Sun Yat-sen University. yanjh79@163.com.|Guangdong Diabetes Center, Guangzhou. yanjh79@163.com.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Yan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003710:Demography; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012042:Registries; D012189:Retrospective Studies; D055815:Young Adult
keywords: 1型糖尿病; China; epidemiology; type 1 diabetes mellitus; 中国; 流行病学