title: The evaluation of non-enzymatic antioxidants effects in limiting tumor- associated oxidative stress, in a tumor rat model.
abstract: Active oxygen species are produced as a consequence of normal aerobic metabolism. Of these, free radicals are usually metabolized or inactivated in vivo by a team of antioxidants. Individual members are a trained team fighting antioxidants to prevent the generation of ROS, destroy or oxidizing potential of capture. In terms of physiological oxidative stress, induced tissue attack is minimal. A relative or absolute deficiency in the antioxidant defense may lead to increased oxidative stress and this event is associated with both the causes and consequences of diseases and cancer, included here. The aim of the study is to identify the role of antioxidant defense systems and the reduction of oxidative stress in dynamic growth and development of malignant tumors. Our in vivo study was developed and referred to carcinosarcoma carriers Wistar rats treated with non-enzymatic antioxidants: vitamin C, vitamin A, zinc salt (II), and arginine in various combinations. Treatment was initiated three weeks before tumor induction.
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: R
authors.initials: R
authors.lastname: Grigorescu
authors.affiliation: "Prof. Dr. Alex. Trestioreanu" Oncological Institute, Bucharest, Romania.
authors.forename: M I
authors.initials: MI
authors.lastname: Gruia
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: V
authors.initials: V
authors.lastname: Nacea
authors.affiliation: "Prof. Dr. Alex. Trestioreanu" Oncological Institute, Bucharest, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Nitu
authors.affiliation: "Prof. Dr. Alex. Trestioreanu" Oncological Institute, Bucharest, Romania.
authors.forename: V
authors.initials: V
authors.lastname: Negoita
authors.affiliation: "Prof. Dr. Alex. Trestioreanu" Oncological Institute, Bucharest, Romania.
authors.forename: D
authors.initials: D
authors.lastname: Glavan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D007501:Iron / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009369:Neoplasms / Q000473:pathology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D013438:Sulfhydryl Compounds; D007501:Iron
keywords: Walker carcinoma 256; malignancy; non-enzymatic antioxidants; oxidative stress