title: Biomimetic Taste Receptors with Chiral Recognition by Photoluminescent Metal-Organic Frameworks Chelated with Polyaniline Helices.
abstract: The adsorption of phenylaniline (Phe) enantiomers on (+)-polyaniline (PAN)-chelated [In(OH)(bdc)]n microcrystals was carefully designed and studied by using the Job titration, circular dichroism, X-ray photoelectron spectroscopy, and photoluminescence to mimic heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors in selective, but not specific, ligand binding with chiral recognition and signal transduction. Six essential working principles across different length scales are unraveled: 1) a chiral (+)-PAN (host), 2) specific sites for Phe-(+)/PAN (guest-host) binding, 3) a conformational change of (+)-PAN after binding with Phe enantiomers, 4) different degrees of packing for (+)-PAN, 5) interactions between (+)-PAN and the underlying signal-generating framework (i.e., [In(OH)(bdc)]n microcrystals), and 6) a systematic photoluminescent signal combination by using principal-component analysis from the other three polymer-chelated metal-organic frameworkds (MOFs), such as poly(acrylic acid) (PAA), sodium alginate (SA), and polyvinylpyrrolidone (PVP) to enhance the selectivity and discrimination capabilities.
authors.affiliation: Department of Chemical and Materials Engineering, National Central University, 300 Jhong-Da Road, Jhong-Li District, Taoyuan City, 32001, Taiwan R.O.C.), Fax. tulee@cc.ncu.edu.tw.
authors.forename: Tu
authors.initials: T
authors.lastname: Lee
authors.affiliation: Department of Chemical and Materials Engineering, National Central University, 300 Jhong-Da Road, Jhong-Li District, Taoyuan City, 32001, Taiwan R.O.C.), Fax.
authors.forename: Tsung Yan
authors.initials: TY
authors.lastname: Lin
authors.affiliation: Department of Chemical and Materials Engineering, National Central University, 300 Jhong-Da Road, Jhong-Li District, Taoyuan City, 32001, Taiwan R.O.C.), Fax.
authors.forename: Hung Lin
authors.initials: HL
authors.lastname: Lee
authors.affiliation: Department of Chemical and Materials Engineering, National Central University, 300 Jhong-Da Road, Jhong-Li District, Taoyuan City, 32001, Taiwan R.O.C.), Fax.
authors.forename: Yun Hsuan
authors.initials: YH
authors.lastname: Chang
authors.affiliation: Department of Chemical and Materials Engineering, National Central University, 300 Jhong-Da Road, Jhong-Li District, Taoyuan City, 32001, Taiwan R.O.C.), Fax.
authors.forename: Yee Chen
authors.initials: YC
authors.lastname: Tsai
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D032701:Biomimetics; D056831:Coordination Complexes / Q000737:chemistry*; D006801:Humans; D008670:Metals / Q000737:chemistry*; D008958:Models, Molecular; D056951:Photoelectron Spectroscopy; D011205:Povidone / Q000737:chemistry*; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism; D000098706:Taste Receptors, Type 2
chemical_list: D000814:Aniline Compounds; D056831:Coordination Complexes; D008670:Metals; D043562:Receptors, G-Protein-Coupled; C416807:polyaniline; C431926:taste receptors, type 1; D000098706:Taste Receptors, Type 2; D011205:Povidone
keywords: (+)-polyaniline; microcrystals; photoelectron spectroscopy; principal-component analysis; receptors