title: Is sebocyte-derived leptin the missing link between hyperseborrhea, ductal hypoxia, inflammation and comedogenesis in acne vulgaris?
authors.affiliation: Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany.
authors.forename: Bodo C
authors.initials: BC
authors.lastname: Melnik
mesh_terms: D000152:Acne Vulgaris / Q000503:physiopathology*; D000818:Animals; D049109:Cell Proliferation; D012628:Dermatitis, Seborrheic / Q000503:physiopathology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D007249:Inflammation / Q000503:physiopathology*; D015603:Keratinocytes / Q000166:cytology; D020738:Leptin / Q000502:physiology*; D000076222:Mechanistic Target of Rapamycin Complex 1; D051379:Mice; D046912:Multiprotein Complexes / Q000378:metabolism; D012627:Sebaceous Glands / Q000166:cytology*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D020738:Leptin; D046912:Multiprotein Complexes; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases
keywords: acne; inflammasome; leptin; mTORC1; western diet