title: Role of Interleukin-10 Gene Promoter Region Polymorphism in the Development of Chronic Lymphoid Leukemia.
abstract: Relationship between interleukin-10 (IL-10) gene G-1082A (rs1800896) polymorphism and the risk of development and stages of chronic lymphoid leukemia is studied in ethnic Russian residents of the Kirov region of Russia. Associations of allele -1082A and genotypes (-1082AA/-1082AG) with the risk of chronic lymphoid leukemia are detected (OR=1.39, 95%CI=1.09-1.78 and OR=1.66, 95%CI=1.09-2.54, respectively). In addition, association of 1082AA genotype with late stages of the disease by the moment of diagnosis is detected. These data indicate that IL-10 polymorphism G-1082A may be involved in the pathogenesis of chronic lymphoid leukemia.
authors.affiliation: Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia. vovsepyan@mail.ru.
authors.forename: V A
authors.initials: VA
authors.lastname: Ovsepyan
authors.affiliation: Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia.
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Gabdulkhakova
authors.affiliation: Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Shubenkiva
authors.affiliation: Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia.
authors.forename: E N
authors.initials: EN
authors.lastname: Zotina
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D044465:White People
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
keywords: chronic lymphoid leukemia; interleukin-10; single nucleotide polymorphism