title: Evaluation of plasma inflammatory cytokine concentrations in racing sled dogs.
abstract: In human athletes significant changes in cytokine concentrations secondary to exercise have been observed. This prospective study evaluated the effect of a multi-day stage sled dog race on plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10). Samples from 20 dogs were harvested prior to and on days 2 and 8 of an 8-day race. Exercise resulted in significantly decreased TNF-α and IL-8 as well as increases of MCP-1, IL-6, and IL-10 concentrations (P-value between 0.01 and < 0.0001 for all parameters). The proportion of values for IL-2 that were below the detection limit increased from 40% on day 0 to 75% on day 2 and decreased on day 8 to 40% (P = 0.04). Racing sled dogs show cytokine-concentration changes that are different from those in humans.
authors.affiliation: Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, Washington, District of Columbia 20016, USA (von Pfeil); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, Wakshlag), Department of Population Medicine (Mann), College of Veterinary Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, Colorado, USA (Griffitts).
authors.forename: Dirsko J F
authors.initials: DJ
authors.lastname: von Pfeil
authors.affiliation: Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, Washington, District of Columbia 20016, USA (von Pfeil); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, Wakshlag), Department of Population Medicine (Mann), College of Veterinary Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, Colorado, USA (Griffitts).
authors.forename: Bethany P
authors.initials: BP
authors.lastname: Cummings
authors.affiliation: Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, Washington, District of Columbia 20016, USA (von Pfeil); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, Wakshlag), Department of Population Medicine (Mann), College of Veterinary Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, Colorado, USA (Griffitts).
authors.forename: John P
authors.initials: JP
authors.lastname: Loftus
authors.affiliation: Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, Washington, District of Columbia 20016, USA (von Pfeil); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, Wakshlag), Department of Population Medicine (Mann), College of Veterinary Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, Colorado, USA (Griffitts).
authors.forename: Corri B
authors.initials: CB
authors.lastname: Levine
authors.affiliation: Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, Washington, District of Columbia 20016, USA (von Pfeil); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, Wakshlag), Department of Population Medicine (Mann), College of Veterinary Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, Colorado, USA (Griffitts).
authors.forename: Sabine
authors.initials: S
authors.lastname: Mann
authors.affiliation: Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, Washington, District of Columbia 20016, USA (von Pfeil); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, Wakshlag), Department of Population Medicine (Mann), College of Veterinary Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, Colorado, USA (Griffitts).
authors.forename: Robert L
authors.initials: RL
authors.lastname: Downey
authors.affiliation: Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, Washington, District of Columbia 20016, USA (von Pfeil); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, Wakshlag), Department of Population Medicine (Mann), College of Veterinary Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, Colorado, USA (Griffitts).
authors.forename: Caroline
authors.initials: C
authors.lastname: Griffitts
authors.affiliation: Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, Washington, District of Columbia 20016, USA (von Pfeil); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, Wakshlag), Department of Population Medicine (Mann), College of Veterinary Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, Colorado, USA (Griffitts).
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Wakshlag
mesh_terms: D000818:Animals; D016207:Cytokines / Q000097:blood* / Q000378:metabolism; D004285:Dogs / Q000097:blood / Q000276:immunology*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D008297:Male; D013177:Sports
chemical_list: D016207:Cytokines