title: Intracellular delivery of biomineralized monoclonal antibodies to combat viral infection.
abstract: Conventional therapeutic monoclonal antibodies (mAbs) are invalid for intracellular viruses but by using in situ biomineralization treatment, they can be successfully delivered into cells to inhibit intracellular viral replication. This achievement significantly expands the applications of mAbs and provides a new intracellular strategy to control viral infections.
authors.affiliation: Center for Biomaterials and Bioparthways Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China. rtang@zju.edu.cn and Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. qincf@bmi.ac.cn.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Song
authors.affiliation: Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. qincf@bmi.ac.cn and Anhui Medical University, Hefei 230032, P. R. China.
authors.forename: Long
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. qincf@bmi.ac.cn and Qiushi Academy for Advanced Studies Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. qincf@bmi.ac.cn.
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. qincf@bmi.ac.cn.
authors.forename: Qinggong
authors.initials: Q
authors.lastname: Nian
authors.affiliation: Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. qincf@bmi.ac.cn and Qiushi Academy for Advanced Studies Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
authors.forename: Guangchuan
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. qincf@bmi.ac.cn.
authors.forename: Shunya
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. qincf@bmi.ac.cn and State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Li
authors.affiliation: Center for Biomaterials and Bioparthways Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China. rtang@zju.edu.cn and Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. qincf@bmi.ac.cn.
authors.forename: Hangyu
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. qincf@bmi.ac.cn and State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Center for Biomaterials and Bioparthways Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China. rtang@zju.edu.cn and Qiushi Academy for Advanced Studies Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
authors.forename: Xurong
authors.initials: X
authors.lastname: Xu
authors.affiliation: Center for Biomaterials and Bioparthways Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China. rtang@zju.edu.cn and Qiushi Academy for Advanced Studies Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
authors.forename: Ruikang
authors.initials: R
authors.lastname: Tang
authors.affiliation: Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. qincf@bmi.ac.cn and Anhui Medical University, Hefei 230032, P. R. China.
authors.forename: Chengfeng
authors.initials: C
authors.lastname: Qin
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D014777:Virus Diseases / Q000517:prevention & control*
chemical_list: D000911:Antibodies, Monoclonal; D002130:Calcium Phosphates; C020243:calcium phosphate