title: [Relationship between hepatitis C virus and the transcription coactivator PGC-1α--A review].
abstract: Approximately 185 million people are or have been infected with Hepatitis C virus ( HCV) worldwide. HCV causes not only severe liver problems but also extra hepatic manifestations, such as insulin resistance (IR) and type 2 diabetes mellitus (T2DM) . Peroxisome proliferator-activated receptor gamma coactivator 1 alpha ( PGC-1α) is a transcription factor coactivator that plays an essential role in cellular energy metabolism, and cumulative studies link the abnormal high expression of PGC-1α to IR and T2DM. Besides, HCV hijacks host lipid metabolism for its infection, and the very low density lipoprotein (VLDL) secretory pathway is exploited to facilitate HCV assembly and secretion; coincidently, PGC-1α is reportedly important in VLDL assembly through a downstream factor. Therefore, we hypothesize that, on the one hand, HCV infection results in WT-PGC-1α/L-PGC-1α high expression which will further lead to T2DM, on the other hand, WT-PGC-1α and L-PGC-1α demonstrate proviral functions in HCV production through the regulation of VLDL. Combining previous studies in the literature with our current findings, we elaborate the relationship between HCV and PGC-1α, and discuss the mechanism how HCV infection upregulates PGC-1α.
authors.forename: Wenxia
authors.initials: W
authors.lastname: Yao
authors.forename: Hua
authors.initials: H
authors.lastname: Cai
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D016174:Hepacivirus / Q000235:genetics / Q000502:physiology*; D006526:Hepatitis C / Q000150:complications / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D006801:Humans; D007333:Insulin Resistance; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors