title: Altered Hippocampal Neurogenesis and Amygdalar Neuronal Activity in Adult Mice with Repeated Experience of Aggression.
abstract: Repeated experience of winning in a social conflict setting elevates levels of aggression and may lead to violent behavioral patterns. Here, we use a paradigm of repeated aggression and fighting deprivation to examine changes in behavior, neurogenesis, and neuronal activity in mice with positive fighting experience. We show that for males, repeated positive fighting experience induces persistent demonstration of aggression and stereotypic behaviors in daily agonistic interactions, enhances aggressive motivation, and elevates levels of anxiety. When winning males are deprived of opportunities to engage in further fights, they demonstrate increased levels of aggressiveness. Positive fighting experience results in increased levels of progenitor cell proliferation and production of young neurons in the hippocampus. This increase is not diminished after a fighting deprivation period. Furthermore, repeated winning experience decreases the number of activated (c-fos-positive) cells in the basolateral amygdala and increases the number of activated cells in the hippocampus; a subsequent no-fight period restores the number of c-fos-positive cells. Our results indicate that extended positive fighting experience in a social conflict heightens aggression, increases proliferation of neuronal progenitors and production of young neurons in the hippocampus, and decreases neuronal activity in the amygdala; these changes can be modified by depriving the winners of the opportunity for further fights.
authors.affiliation: Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences Novosibirsk, Russia ; Department of Nano-, Bio-, Information Technology and Cognitive Science, Moscow Institute of Physics and Technology Moscow, Russia ; Cold Spring Harbor Laboratory, Cold Spring Harbor NY, USA.
authors.forename: Dmitry A
authors.initials: DA
authors.lastname: Smagin
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor NY, USA.
authors.forename: June-Hee
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Nano-, Bio-, Information Technology and Cognitive Science, Moscow Institute of Physics and Technology Moscow, Russia ; Cold Spring Harbor Laboratory, Cold Spring Harbor NY, USA ; Department of Anesthesiology, Stony Brook School of Medicine Stony Brook, NY, USA ; Center for Developmental Genetics, Stony Brook University Stony Brook, NY, USA.
authors.forename: Tatyana V
authors.initials: TV
authors.lastname: Michurina
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor NY, USA ; Department of Anesthesiology, Stony Brook School of Medicine Stony Brook, NY, USA ; Center for Developmental Genetics, Stony Brook University Stony Brook, NY, USA.
authors.forename: Natalia
authors.initials: N
authors.lastname: Peunova
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor NY, USA.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Glass
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor NY, USA.
authors.forename: Kasim
authors.initials: K
authors.lastname: Sayed
authors.affiliation: Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences Novosibirsk, Russia.
authors.forename: Natalya P
authors.initials: NP
authors.lastname: Bondar
authors.affiliation: Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences Novosibirsk, Russia.
authors.forename: Irina N
authors.initials: IN
authors.lastname: Kovalenko
authors.affiliation: Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences Novosibirsk, Russia.
authors.forename: Natalia N
authors.initials: NN
authors.lastname: Kudryavtseva
authors.affiliation: Department of Nano-, Bio-, Information Technology and Cognitive Science, Moscow Institute of Physics and Technology Moscow, Russia ; Cold Spring Harbor Laboratory, Cold Spring Harbor NY, USA ; Department of Anesthesiology, Stony Brook School of Medicine Stony Brook, NY, USA ; Center for Developmental Genetics, Stony Brook University Stony Brook, NY, USA.
authors.forename: Grigori
authors.initials: G
authors.lastname: Enikolopov
keywords: adult neurogenesis; aggression; amygdala; anxiety; autism; c-fos-positive cells; hippocampus; social conflict