title: Targeting Transient Receptor Potential Canonical Channels for Diseases of the Nervous System.
abstract: BACKGROUND
  Ca2+ influx plays an essential role in the physiological and pathophysiologic processes of several nervous system diseases. The transient receptor-potential channels (TRPCs) form a family of voltage -sensitive calcium ion channels.
  
  
  OBJECTIVE
  In this review, we will discuss the importance of transient receptor potential canonical (TRPC) channels, which is a crucial family of calcium channels. This article reviews the role of TRPC channels in the pathogenesis of diseases such as brain hemorrhage, hemorrhagic transformation after cerebral infarction, subarachnoid hemorrhage, and brain injury.
  
  
  RESULTS
  TRPC has especially high expression in the central nervous system (CNS), and was involved in several physiological functions. The TRPC family is associated with cerebral vasospasm after subarachnoid hemorrhage, neuronal damage after intracerebral hemorrhage, NMDA cytotoxicity in cerebral ischemia, nervous system tumors, neurodegenerative diseases, neural addiction and other diseases.
  
  
  CONCLUSIONS
  The TRPC family has rich functionality and is widely distributed, with different functions in various nervous system diseases.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Wang
authors.forename: Jiyuan
authors.initials: J
authors.lastname: Bu
authors.forename: Haitao
authors.initials: H
authors.lastname: Shen
authors.forename: Haiying
authors.initials: H
authors.lastname: Li
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D055785:Gene Knockdown Techniques; D006801:Humans; D058990:Molecular Targeted Therapy; D015398:Signal Transduction / Q000187:drug effects; D050051:Transient Receptor Potential Channels / Q000235:genetics* / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D015220:Calcium Channels; D050051:Transient Receptor Potential Channels
keywords: Brain injury; Ca2+; TRPCs; hemorrhagic transformation; intracerebral hemorrhage; nerve system; subarachnoid hemorrhage