title: Current Status of Research on Osteoporosis after Solid Organ Transplantation: Pathogenesis and Management.
abstract: Improved survival following organ transplantation has brought to the forefront some long-term complications, among which osteoporosis and associated fractures are the major ones that adversely affect the quality of life in recipients. The pathogenesis of osteoporosis in transplant recipients is complex and multifactorial which may be related to increased bone resorption, decreased bone formation, or both. Studies have shown that the preexisting underlying metabolic bone disorders and the use of immunosuppressive agents are the major risk factors for osteoporosis and fractures after organ transplantation. And rapid bone loss usually occurs in the first 6-12 months with a significant increase in fracture risk. This paper will provide an updated review on the possible pathogenesis of posttransplant osteoporosis and fractures, the natural history, and the current prevention and treatment strategies concerning different types of organ transplantation.
authors.affiliation: Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
authors.forename: Gong-bin
authors.initials: GB
authors.lastname: Lan
authors.affiliation: Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
authors.forename: Xu-biao
authors.initials: XB
authors.lastname: Xie
authors.affiliation: Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
authors.forename: Long-kai
authors.initials: LK
authors.lastname: Peng
authors.affiliation: Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Song
authors.affiliation: Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
authors.forename: He-long
authors.initials: HL
authors.lastname: Dai
mesh_terms: D015519:Bone Density; D001862:Bone Resorption / Q000473:pathology; D001842:Bone and Bones; D016027:Heart Transplantation; D006801:Humans; D016030:Kidney Transplantation; D016031:Liver Transplantation; D010024:Osteoporosis / Q000473:pathology / Q000628:therapy*; D012307:Risk Factors