title: Discrimination between bacterial species by ratiometric analysis of their carbohydrate binding profile.
abstract: Antibiotic resistance is a global health concern meaning there is an urgent need for new treatments and diagnostics. Here glycosylated surfaces are used to profile the binding patterns of a range of Gram-negative, Gram-positive and mycobacteria. This enables the creation of 'barcodes' to enable identification and discrimination between the strains, which could not be achieved by single-point glycan binding and offers a new concept in bacteria detection.
authors.affiliation: Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. m.i.gibson@warwick.ac.uk.
authors.forename: Lucienne
authors.initials: L
authors.lastname: Otten
authors.affiliation: School of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry, UK.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Fullam
authors.affiliation: Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. m.i.gibson@warwick.ac.uk.
authors.forename: Matthew I
authors.initials: MI
authors.lastname: Gibson
mesh_terms: D000117:Acetylglucosamine / Q000737:chemistry; D001089:Arabinose / Q000737:chemistry; D001422:Bacterial Adhesion; D015374:Biosensing Techniques; D002475:Cellobiose / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry; D016002:Discriminant Analysis; D004926:Escherichia coli / Q000502:physiology*; D005690:Galactose / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D005985:Glyceraldehyde / Q000737:chemistry; D007785:Lactose / Q000737:chemistry; D008358:Mannose / Q000737:chemistry; D019910:Mycobacterium marinum / Q000502:physiology*; D020102:Mycobacterium smegmatis / Q000502:physiology*; D016958:Pseudomonas putida / Q000502:physiology*
chemical_list: D003911:Dextrans; D002475:Cellobiose; D005985:Glyceraldehyde; D001089:Arabinose; D005947:Glucose; D007785:Lactose; D008358:Mannose; D000117:Acetylglucosamine; D005690:Galactose