title: Comment on: "A Physiologically Based Pharmacokinetic Drug-Disease Model to Predict Carvedilol Exposure in Adult and Paediatric Heart Failure Patients by Incorporating Pathophysiological Changes in Hepatic and Renal Blood".
authors.affiliation: Center for Drug Clinical Research, Shanghai University of Chinese Medicine, No. 1200 Cailun Road, 201203, Shanghai, China. li.guofu@yahoo.com.
authors.forename: Guo-Fu
authors.initials: GF
authors.lastname: Li
authors.affiliation: Yangzhou Maternal and Child Care Service Center, Yangzhou University, Yangzhou, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Gu
authors.affiliation: Laboratory of Pharmacogenomics and Pharmacokinetic Research, Subei People's Hospital, Yangzhou, China.|Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Yu
authors.affiliation: Center for Drug Clinical Research, Shanghai University of Chinese Medicine, No. 1200 Cailun Road, 201203, Shanghai, China.
authors.forename: Shui-Yu
authors.initials: SY
authors.lastname: Zhao
authors.affiliation: Center for Drug Clinical Research, Shanghai University of Chinese Medicine, No. 1200 Cailun Road, 201203, Shanghai, China. qingshan.zheng@drugchina.net.
authors.forename: Qing-Shan
authors.initials: QS
authors.lastname: Zheng
mesh_terms: D002227:Carbazoles / Q000493:pharmacokinetics*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male; D008954:Models, Biological; D011412:Propanolamines / Q000493:pharmacokinetics*; D012079:Renal Circulation / Q000187:drug effects*
chemical_list: D002227:Carbazoles; D011412:Propanolamines