title: Sensitive detection and glycoprofiling of a prostate specific antigen using impedimetric assays.
abstract: This study presents a proof-of-concept for the development of an impedimetric biosensor for ultra-sensitive glycoprofiling of prostate specific antigen (PSA). The biosensor exhibits three unique characteristics: (1) analysis of PSA with limit of detection (LOD) down to 4 aM; (2) analysis of the glycan part of PSA with LOD down to 4 aM level and; (3) both assays (i.e., PSA quantification and PSA glycoprofiling) can be performed on the same interface due to label-free analysis.
authors.affiliation: Department of Glycobiotechnology, Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava, 845 38, Slovak Republic. Jan.Tkac@savba.sk.
authors.forename: D
authors.initials: D
authors.lastname: Pihíková
authors.forename: Š
authors.initials: Š
authors.lastname: Belicky
authors.forename: P
authors.initials: P
authors.lastname: Kasák
authors.forename: T
authors.initials: T
authors.lastname: Bertok
authors.forename: J
authors.initials: J
authors.lastname: Tkac
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D058266:Dielectric Spectroscopy; D006801:Humans; D057230:Limit of Detection; D037121:Plant Lectins / Q000378:metabolism; D011134:Polysaccharides / Q000032:analysis* / Q000378:metabolism; D017430:Prostate-Specific Antigen / Q000737:chemistry*
chemical_list: D037121:Plant Lectins; D011134:Polysaccharides; D017430:Prostate-Specific Antigen