title: Isoflurane Post-Treatment Improves Outcome after an Embolic Stroke in Rabbits.
abstract: Application of commonly used volatile anesthetics after brain ischemia onset (post-treatment) provides neuroprotection in rodents. To further test its translational potential, this study was designed to determine whether isoflurane post-treatment induced neuroprotection in rabbits after embolic stroke. White male New Zealand rabbits received intra-carotid injection of clots when they were awake. Some rabbits were exposed to 2.5% isoflurane for 1 h at 5 min after the injection. Isoflurane post-treatment increased the tolerance of rabbits to the amount of clots. Isoflurane post-treatment also reduced brain infarct volumes and plasma S100B 3 days after the injection of 5 mg clots and improved neurological deficit scores after the stroke. Isoflurane post-treatment improves neurological outcome in rabbits after embolic stroke.
authors.affiliation: Department of Anesthesiology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Anesthesiology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Zonghong
authors.initials: Z
authors.lastname: Long
authors.affiliation: Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Anesthesiology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.|Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, United States of America.
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Zuo
authors.affiliation: Department of Anesthesiology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
mesh_terms: D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000818:Animals; D002544:Cerebral Infarction / Q000150:complications / Q000628:therapy*; D004617:Embolism / Q000150:complications / Q000628:therapy*; D007530:Isoflurane / Q000008:administration & dosage*; D008297:Male; D011817:Rabbits; D016896:Treatment Outcome
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane