title: Towards Multidisciplinary HIV-Cure Research: Integrating Social Science with Biomedical Research.
abstract: The quest for a cure for HIV remains a timely and key challenge for the HIV research community. Despite significant scientific advances, current HIV therapy regimens do not completely eliminate the negative impact of HIV on the immune system; and the economic impact of treating all people infected with HIV globally, for the duration of their lifetimes, presents significant challenges. This article discusses, from a multidisciplinary approach, critical social, behavioral, ethical, and economic issues permeating the HIV-cure research agenda. As part of a search for an HIV cure, both the perspective of patients/participants and clinical researchers should be taken into account. In addition, continued efforts should be made to involve and educate the broader community.
authors.affiliation: 5601 Fishers Lane Room 9G19, MSC 9831, National Institutes of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD 20892, USA. Electronic address: grossmanc@mail.nih.gov.
authors.forename: Cynthia I
authors.initials: CI
authors.lastname: Grossman
authors.affiliation: ANRS, 101 rue de Tolbiac, 75013 Paris, France.
authors.forename: Anna Laura
authors.initials: AL
authors.lastname: Ross
authors.affiliation: Center for AIDS Prevention Studies, Department of Medicine, School of Medicine, University of California, Mailcode 0886, 550 16th Street, 3rd Floor, San Francisco, CA 94158, USA.
authors.forename: Judith D
authors.initials: JD
authors.lastname: Auerbach
authors.affiliation: 6720A Rockledge Drive, Suite 400, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA.
authors.forename: Jintanat
authors.initials: J
authors.lastname: Ananworanich
authors.affiliation: 120 Mason Farm Road, #2047 Genetic Medicine Building, Institute of Global Health and Infectious Diseases (IGHID), Collaboratory of AIDS Researchers for Eradication (CARE), Chapel Hill, NC 27516, USA.
authors.forename: Karine
authors.initials: K
authors.lastname: Dubé
authors.affiliation: UNC Project-China, 2 Lujing Road, Guangzhou, China, 510095; and University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Tucker
authors.affiliation: Sidaction, 228 rue Faubourg Saint-Martin, 75010 Paris, France.
authors.forename: Veronica
authors.initials: V
authors.lastname: Noseda
authors.affiliation: Oswaldo Cruz Foundation, Evandro Chagas National Institute of Infectious Diseases and Bio-Manguinhos, Avenida Brazil 4365 Manguinhos, CEP 21040-360, Rio de Janeiro, Brazil.
authors.forename: Cristina
authors.initials: C
authors.lastname: Possas
authors.affiliation: 5601 Fishers Lane Room 9G19, MSC 9831, National Institutes of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
authors.forename: Dianne M
authors.initials: DM
authors.lastname: Rausch
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000628:therapy; D035843:Biomedical Research / Q000191:economics / Q000941:ethics / Q000379:methods* / Q000639:trends; D002986:Clinical Trials as Topic / Q000191:economics / Q000941:ethics / Q000379:methods; D003299:Cooperative Behavior; D003362:Cost-Benefit Analysis; D015658:HIV Infections / Q000628:therapy*; D006801:Humans; D033183:Interdisciplinary Communication; D012074:Remission Induction; D012942:Social Sciences / Q000191:economics / Q000941:ethics / Q000379:methods* / Q000639:trends
keywords: HIV cure; cost-effectiveness; ethics; multidisciplinary; public understanding of science