title: The exon junction complex as a node of post-transcriptional networks.
abstract: The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a unique structure, which can both stably bind to mRNAs and function as an anchor for diverse processing factors. Recent findings revealed that in addition to its established roles in nonsense-mediated mRNA decay, the EJC is involved in mRNA splicing, transport and translation. While structural studies have shed light on EJC assembly, transcriptome-wide analyses revealed differential EJC loading at spliced junctions. Thus, the EJC functions as a node of post-transcriptional gene expression networks, the importance of which is being revealed by the discovery of increasing numbers of EJC-related disorders.
authors.affiliation: Ecole Normale Supérieure, Institut de Biologie de l'ENS (IBENS), Paris, F-75005, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Le Hir
authors.affiliation: Ecole Normale Supérieure, Institut de Biologie de l'ENS (IBENS), Paris, F-75005, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Saulière
authors.affiliation: Ecole Normale Supérieure, Institut de Biologie de l'ENS (IBENS), Paris, F-75005, France.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D004194:Disease / Q000235:genetics; D005091:Exons / Q000235:genetics*; D053263:Gene Regulatory Networks; D006801:Humans; D008957:Models, Genetic; D020871:RNA Stability / Q000235:genetics; D014158:Transcription, Genetic