title: Platelet parameters and expression of platelet membrane glycoprotein in childhood acute lymphoblastic leukemia.
abstract: Platelet activation and functional changes were investigated in acute lymphoblastic leukemia (ALL) to provide the basis for early diagnosis and evaluation of curative effect. Platelet parameters, immature platelet fraction (IPF%), immature platelet count (IPC), P-selectin (CD62p) (PAC-1) expression were detected in ALL, ALL-complete remission-induced (CR1), and normal groups with an automatic blood cell analyzer and flow cytometer. CD62p and PAC-1 were higher in the ALL group before adenosine-5-diphosphate (ADP) activation than in the normal group (P < 0.05); PAC-1 expression was higher and lower in the ALL-CR1 group than in normal and ALL groups (P < 0.05), respectively. CD62p and PAC-1 expression was lower in the ALL group than in the normal group after ADP activation (P < 0.05); PAC-1 expression was lower and higher in the ALL-CR1 group than in normal and ALL groups, respectively (P < 0.05). Platelet count (PLT), mean platelet volume (MPV), platelet hematocrit (PCT), and platelet distribution width (PDW) were lower in the ALL group than in the ALL-CR1 group (P < 0.05). PLT, MPV, and PCT did not differ between the ALL-CR1 group and the normal group (P > 0.05). PDW did not differ statistically among all groups (P > 0.05). IPF% and IPC values were higher and lower in the ALL group than in normal and ALL-CR1 groups (P < 0.05), respectively. These did not differ significantly between the normal group and the ALL-CR1 group (P > 0.05). Therefore, ALL patients demonstrate platelet activation and platelet dysfunction; platelet parameters and membrane glycoprotein expression can be used to evaluate the effect of ALL.
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sichuan Medical University, Luzhou, Sichuan Province, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sichuan Medical University, Luzhou, Sichuan Province, China.
authors.forename: W J
authors.initials: WJ
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sichuan Medical University, Luzhou, Sichuan Province, China.
authors.forename: Q L
authors.initials: QL
authors.lastname: Guo
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sichuan Medical University, Luzhou, Sichuan Province, China.
authors.forename: C Y
authors.initials: CY
authors.lastname: Liu
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism / Q000494:pharmacology; D000367:Age Factors; D001792:Blood Platelets / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D019007:P-Selectin / Q000378:metabolism; D015539:Platelet Activation / Q000187:drug effects; D010979:Platelet Function Tests; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000378:metabolism*; D012737:Sex Factors
chemical_list: D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins; D000244:Adenosine Diphosphate