title: In Vivo Biodistribution and Toxicity of Highly Soluble PEG-Coated Boron Nitride in Mice.
abstract: The boron nitride (BN) nanoparticles, as the structural analogues of graphene, are the potential biomedicine materials because of the excellent biocompatibility, but their solubility and biosafety are the biggest obstacle for the clinic application. Here, we first synthesized the highly soluble BN nanoparticles coated by PEG (BN-PEG) with smaller size (~10 nm), then studied their biodistribution in vivo through radioisotope (Tc(99m)O4 (-)) labeling, and the results showed that BN-PEG nanoparticles mainly accumulated in the liver, lung, and spleen with the less uptake by the brain. Moreover, the pathological changes induced by BN-PEG could be significantly observed in the sections of the liver, lung, spleen, and heart, which can be also supported by the test of biochemical indexes in serum. More importantly, we first observed the biodistribution of BN-PEG in the heart tissues with high toxicity, which would give a warning about the cardiovascular disease, and provide some opportunities for the drug delivery and treatment.
authors.affiliation: Radiochemistry Laboratory, Lanzhou University, Lanzhou, Gansu, 730000, China. xibeizhanliubo@163.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.affiliation: Huazhong University of Science and Technology, Wuhan, 430074, China. qiweilzu@gmail.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Qi
authors.affiliation: Radiochemistry Laboratory, Lanzhou University, Lanzhou, Gansu, 730000, China.
authors.forename: Longlong
authors.initials: L
authors.lastname: Tian
authors.affiliation: Key Laboratory of Chemistry of Northwestern Plant Resources, Key Laboratory for Natural Medicine of Gansu Province, Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu, 730000, China. lizhancg@licp.cas.cn.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Radiotherapy, Gansu Provincial Hospital, Lanzhou, Gansu, 730000, China.
authors.forename: Guoying
authors.initials: G
authors.lastname: Miao
authors.affiliation: School of Life Sciences, Lanzhou University, Lanzhou, Gansu, 730000, China.
authors.forename: Wenzhen
authors.initials: W
authors.lastname: An
authors.affiliation: Radiochemistry Laboratory, Lanzhou University, Lanzhou, Gansu, 730000, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.affiliation: Radiochemistry Laboratory, Lanzhou University, Lanzhou, Gansu, 730000, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang, 330031, China.
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Radiochemistry Laboratory, Lanzhou University, Lanzhou, Gansu, 730000, China. wuws@lzu.edu.cn.
authors.forename: Wangsuo
authors.initials: W
authors.lastname: Wu
keywords: Biodistribution; Boron nitride (BN); Soluble; Toxicity