title: Simulation of avascular tumor growth by agent-based game model involving phenotype-phenotype interactions.
abstract: All tumors, both benign and metastatic, undergo an avascular growth stage with nutrients supplied by the surrounding tissue. This avascular growth process is much easier to carry out in more qualitative and quantitative experiments starting from tumor spheroids in vitro with reliable reproducibility. Essentially, this tumor progression would be described as a sequence of phenotypes. Using agent-based simulation in a two-dimensional spatial lattice, we constructed a composite growth model in which the phenotypic behavior of tumor cells depends on not only the local nutrient concentration and cell count but also the game among cells. Our simulation results demonstrated that in silico tumors are qualitatively similar to those observed in tumor spheroid experiments. We also found that the payoffs in the game between two living cell phenotypes can influence the growth velocity and surface roughness of tumors at the same time. Finally, this current model is flexible and can be easily extended to discuss other situations, such as environmental heterogeneity and mutation.
authors.affiliation: Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou University, Lanzhou 730000, China.|Center of Soft Matter Physics and its Applications, Beihang University, Beijing 100191, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.affiliation: School of Physics and Information Technology, Shaanxi Normal University, Xi'an 710119, China.
authors.forename: Hengtong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Institute of Pathology, Lanzhou University, Lanzhou 730000, China.
authors.forename: Jiangang
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Chen
authors.affiliation: Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou University, Lanzhou 730000, China.
authors.forename: Yumin
authors.initials: Y
authors.lastname: Li
mesh_terms: D000465:Algorithms; D049109:Cell Proliferation; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology*; D010641:Phenotype