title: Learning curve and interobserver variance in quantification of the optical coherence tomography attenuation coefficient.
abstract: The learning curve and interobserver variance of attenuation coefficient (μOCT ) determination from optical coherence tomography (OCT) images were quantified. The μOCT of normal and diseased vulvar tissues was determined at five time points by three novice students and three OCT experts who reached consensus for reference. Students received feedback between time points. Eventually, variance in μOCT was smaller in images of diseased tissue than in images of normal vulvar tissue. The difference between the consensus and student μOCT values was larger for smaller values of μOCT . We conclude that routine μOCT determination for tissue classification does not require extensive training.
authors.affiliation: Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Department of Surgery, P.O. Box 90203, 1006 BE Amsterdam, The Netherlands.
authors.forename: Ronni
authors.initials: R
authors.lastname: Wessels
authors.affiliation: Academic Medical Center-University of Amsterdam, Department of Biomedical Engineering and Physics, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandscAcademic Medical Center-University of Amsterdam, Department of Urology, Meibergdreef 9, 1105 AZ Amsterdam.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: de Bruin
authors.affiliation: Academic Medical Center-University of Amsterdam, Department of Biomedical Engineering and Physics, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: Dirk J
authors.initials: DJ
authors.lastname: Faber
authors.affiliation: Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Department of Pathology, P.O. Box 90203, 1006 BE Amsterdam, The Netherlands.
authors.forename: Joyce
authors.initials: J
authors.lastname: Sanders
authors.affiliation: Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Department of Biometrics, P.O. Box 90203, 1006 BE Amsterdam, The Netherlands.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Vincent
authors.affiliation: Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Department of Gynaecology, P.O. Box 90203, 1006 BE Amsterdam, The Netherlands.
authors.forename: Marc
authors.initials: M
authors.lastname: van Beurden
authors.affiliation: Academic Medical Center-University of Amsterdam, Department of Biomedical Engineering and Physics, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: Ton G
authors.initials: TG
authors.lastname: van Leeuwen
authors.affiliation: Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Department of Surgery, P.O. Box 90203, 1006 BE Amsterdam, The NetherlandsgUniversity of Twente, MIRA Institute, Nanobiophysics Group, Enschede, The Netherlands.
authors.forename: Theo J M
authors.initials: TJ
authors.lastname: Ruers
mesh_terms: D019540:Area Under Curve; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D059032:Learning Curve; D015588:Observer Variation; D055620:Optical Phenomena; D019047:Phantoms, Imaging; D012372:ROC Curve; D012867:Skin / Q000473:pathology; D041623:Tomography, Optical Coherence; D014844:Vulva / Q000473:pathology*; D014845:Vulvar Diseases / Q000175:diagnosis / Q000473:pathology; D014846:Vulvar Neoplasms / Q000175:diagnosis / Q000473:pathology*