title: Bioactive Constituents from the Aerial Parts of Lippia triphylla.
abstract: Five new compounds, lippianosides A (1), B (2), C (3), D (4), and E (5), along with 26 (6-31) known ones were obtained from the 95% EtOH extract of Lippia triphylla (L. triphylla) aerial parts collected from Rwanda, Africa. Among the known compounds, 11 and 17-30 were isolated from the Lippia genus for the first time. In addition, 12, 13, and 16 were firstly obtained from this species. The structures of them were elucidated by chemical and spectroscopic methods. The antioxidant and triglyceride accumulation inhibition effects of the 31 compounds were examined in L6 cells and HepG2 cells, respectively.
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. zhwwxzh@263.net.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. chenyue19890126@sina.com.
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin 300193, China. 13622103155@163.com.
authors.forename: Shiyu
authors.initials: S
authors.lastname: Wang
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. dongyongzhe44@hotmail.com.
authors.forename: Yongzhe
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin 300193, China. 18202682964@163.com.
authors.forename: Tingting
authors.initials: T
authors.lastname: Wang
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. qululuhan88@163.com.
authors.forename: Lu
authors.initials: L
authors.lastname: Qu
authors.affiliation: Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin 300193, China. linan20080402@163.com.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.affiliation: Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin 300193, China. wangtao@tjutcm.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D056945:Hep G2 Cells; D006801:Humans; D032411:Lippia / Q000737:chemistry*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000473:pathology; D035261:Plant Components, Aerial / Q000737:chemistry*; D051381:Rats; D014280:Triglycerides / Q000378:metabolism; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D014280:Triglycerides; D014315:Triterpenes; C554210:lippiolide
keywords: HepG2 cells; L6 cells; Lippia triphylla; antioxidant; lippianoside; structure elucidation; triglyceride accumulation inhibition