title: The 'Adapted ADAPTE': an approach to improve utilization of the ADAPTE guideline adaptation resource toolkit in the Alexandria Center for Evidence-Based Clinical Practice Guidelines.
abstract: OBJECTIVE
  The ADAPTE methodology for adaptation of guidelines has been used by many organizations to develop high-quality clinical practice guidelines. Although it is a valid alternative for de novo development of guidelines, it might demand more time and resources in some institutions. The present study demonstrates the proposed 'adapted ADAPTE' methodology to support more clarity, simplicity and practicality. It also aims at avoiding duplication within the process and reducing the resources and time allocated to the CPG adaptation projects.
  
  
  METHODS
  Clinical guidelines' adaptation in the Center for Evidence-Based Clinical Practice Guidelines at the Alexandria Faculty of Medicine and University Hospitals involves two stages: (1) cross-sectional or retrospective study to reveal the current practice and prescribing patterns concerning the selected health topic; (2) the 'adapted ADAPTE' methodology for CPGs adaptation that was based on the original ADAPTE Process.
  
  
  RESULTS
  The 'adapted ADAPTE' included three modified tools, three new tools based on the original ADAPTE framework and alternatives for four ADAPTE steps to enhance utilization. The finalized adapted CPGs included nine high priority topics for paediatrics and two topics for emergency medicine.
  
  
  CONCLUSIONS
  The ADAPTE methodology for guideline adaptation can be customized or 'adapted' to the local health care setting and resources. This proposal facilitates supports and improves the utilization and update of the ADAPTE process by CPG programmes or activities in health care organizations. This is of particular importance in health care systems in developing countries with limited resources in the Eastern Mediterranean region like Egypt.
authors.affiliation: Alexandria Center for EBCPGs, Healthcare Quality Directorate, University New Hospital, Faculty of Medicine Alexandria University, Alexandria, Egypt.|Alexandria University Children's Hospital at Elshatby, Alexandria University, Alexandria, Egypt.|Guidelines International Network, Adaptation Working Group (steering group).
authors.forename: Yasser Sami
authors.initials: YS
authors.lastname: Amer
authors.affiliation: Alexandria Center for EBCPGs, Healthcare Quality Directorate, University New Hospital, Faculty of Medicine Alexandria University, Alexandria, Egypt.|Department of Pediatrics, Faculty of Medicine, Alexandria University Children's Hospital at Elshatby Alexandria University, Alexandria, Egypt.
authors.forename: Mahmoud Munir
authors.initials: MM
authors.lastname: Elzalabany
authors.affiliation: Alexandria Center for EBCPGs, Healthcare Quality Directorate, University New Hospital, Faculty of Medicine Alexandria University, Alexandria, Egypt.|Department of Pediatrics, Faculty of Medicine, Alexandria University Children's Hospital at Elshatby Alexandria University, Alexandria, Egypt.
authors.forename: Tarek Ismael
authors.initials: TI
authors.lastname: Omar
authors.affiliation: Alexandria Center for EBCPGs, Healthcare Quality Directorate, University New Hospital, Faculty of Medicine Alexandria University, Alexandria, Egypt.|Department of Community Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
authors.forename: Afaf Gaber
authors.initials: AG
authors.lastname: Ibrahim
authors.affiliation: Alexandria Center for EBCPGs, Healthcare Quality Directorate, University New Hospital, Faculty of Medicine Alexandria University, Alexandria, Egypt.|Department of Experimental Surgery, Medical Research Institute, Alexandria University, Alexandria, Egypt.|Alexandria Center for Evidence-Based Medicine, Medical Research Institute, Alexandria University, Alexandria, Egypt.
authors.forename: Nabil Lotfy
authors.initials: NL
authors.lastname: Dowidar
mesh_terms: D019317:Evidence-Based Medicine / Q000458:organization & administration*; D019983:Guideline Adherence / Q000458:organization & administration*; D006739:Hospital Administration / Q000379:methods* / Q000592:standards*; D006801:Humans; D017410:Practice Guidelines as Topic / Q000592:standards*
keywords: adaptation; clinical guidelines; experience; health care