title: Sensitivity of multifocal electroretinography (mfERG) in detecting siderosis.
abstract: OBJECTIVE
  To evaluate use of multifocal electroretinography (mfERG) in diagnosing retinal toxicity from siderosis with normal ERG.
  
  
  METHODS
  Prospective case series.
  
  
  METHODS
  Six patients with retained intraocular foreign body were recruited.
  
  
  METHODS
  The affected eye of the patients had no clinical evidence of siderosis, had similar full-field photopic 3.0 ERG compared with the fellow eye, and had subnormal visual acuity. Group averages in each MfERG ring for implicit time and amplitude at P1 wave were compared between affected and fellow eye to look for latent siderosis.
  
  
  RESULTS
  On mfERG, no statistical difference in group averaged amplitude was observed; however, a significant difference (p < 0.05) was found in group averaged latency between fellow and affected eye at most tested rings (<2 degree, 2-5 degree, and >15 degree rings). Average latency for overall retinal area mapped also showed significant difference (p = 0.010).
  
  
  CONCLUSIONS
  Increased mfERG latency may serve as an early predictor of retinal damage from siderosis when full-field ERG is normal.
authors.affiliation: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi;. Electronic address: dr.shikhagupta84@gmail.com.
authors.forename: Shikha
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi;
authors.forename: Neha
authors.initials: N
authors.lastname: Midha
authors.affiliation: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi;
authors.forename: Varun
authors.initials: V
authors.lastname: Gogia
authors.affiliation: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi;
authors.forename: Pranita
authors.initials: P
authors.lastname: Sahay
authors.affiliation: Department of Biostatistics, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Veena
authors.initials: V
authors.lastname: Pandey
authors.affiliation: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi;
authors.forename: Pradeep
authors.initials: P
authors.lastname: Venkatesh
mesh_terms: D000293:Adolescent; D000328:Adult; D004596:Electroretinography; D005129:Eye Foreign Bodies / Q000209:etiology*; D015807:Eye Injuries, Penetrating / Q000209:etiology; D006486:Hemosiderosis / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D058085:Iron Compounds; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012160:Retina / Q000293:injuries; D012164:Retinal Diseases / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D012680:Sensitivity and Specificity; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D058085:Iron Compounds