title: Mannose-Binding Lectin Levels and Carotid Intima-Media Thickness in Type 2 Diabetic Patients.
abstract: BACKGROUND
  Mannose-binding lectin (MBL) activates complement system and has been suggested to play a role in vascular complications in diabetics. Carotid intima-media thickness (cIMT) detects subclinical atherosclerosis. We evaluated the association of MBL and IMT in type 2 diabetic (T2DM) patients.
  
  
  METHODS
  Serum MBL levels and cIMT were measured in a total of 103 diabetics and in 98 age-matched healthy controls.
  
  
  RESULTS
  There was no significant difference in MBL level in T2DM versus controls. As expected, IMT was significantly higher in T2DM patients than in controls (P = 0.001). In T2DM, the lowest cIMT was seen in patients with normal MBL level (500-1000) while cIMT continuously increased with both high MBL and absolute MBL deficiency states. This was especially significant in high MBL versus normal MBL T2DM patients (P = 0.002). According to multiple regression analysis the main predictors of IMT in T2DM are age (P < 0.003), ApoA level (P = 0.023), and the MBL (P = 0.036).
  
  
  CONCLUSIONS
  Our results suggest a dual role of MBL as a risk factor for cIMT in T2DM. MBL may also be used as a marker of macrovascular disease, as both low and high levels indicate the susceptibility for atherosclerosis in T2DM.
authors.affiliation: Division of Metabolic Diseases, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei Körút 98, Debrecen 4032, Hungary.
authors.forename: Miklós
authors.initials: M
authors.lastname: Káplár
authors.affiliation: Royal London Hospital, Barts Health NHS Trust, Whitechapel Road, London E1 1BB, UK.
authors.forename: Shah
authors.initials: S
authors.lastname: Sweni
authors.affiliation: Division of Metabolic Diseases, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei Körút 98, Debrecen 4032, Hungary.
authors.forename: Julianna
authors.initials: J
authors.lastname: Kulcsár
authors.affiliation: Division of Metabolic Diseases, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei Körút 98, Debrecen 4032, Hungary.
authors.forename: Barbara
authors.initials: B
authors.lastname: Cogoi
authors.affiliation: Division of Metabolic Diseases, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei Körút 98, Debrecen 4032, Hungary.
authors.forename: Regina
authors.initials: R
authors.lastname: Esze
authors.affiliation: Division of Metabolic Diseases, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei Körút 98, Debrecen 4032, Hungary.
authors.forename: Sándor
authors.initials: S
authors.lastname: Somodi
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei Körút 98, Debrecen 4032, Hungary.
authors.forename: Mária
authors.initials: M
authors.lastname: Papp
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Debrecen, Móricz Zsigmond Körtér 22, Debrecen 4032, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Oláh
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Debrecen, Móricz Zsigmond Körtér 22, Debrecen 4032, Hungary.
authors.forename: Mária Tünde
authors.initials: MT
authors.lastname: Magyar
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Debrecen, Móricz Zsigmond Körtér 22, Debrecen 4032, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Szabó
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Debrecen, Móricz Zsigmond Körtér 22, Debrecen 4032, Hungary.
authors.forename: Katalin Réka
authors.initials: KR
authors.lastname: Czuriga-Kovács
authors.affiliation: Clinical Research Center, Faculty of Medicine, University of Debrecen, Tuzoltó Utca 37-47, Budapest 1094, Hungary ; Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
authors.forename: Jolán
authors.initials: J
authors.lastname: Hársfalvi
authors.affiliation: Division of Metabolic Diseases, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei Körút 98, Debrecen 4032, Hungary.
authors.forename: György
authors.initials: G
authors.lastname: Paragh
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D015415:Biomarkers / Q000097:blood; D059168:Carotid Intima-Media Thickness; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood*; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D037601:Mannose-Binding Lectin