title: Facile synthesis of aza-spirocyclopropanyl oxindoles by the reaction of 3-(2-bromoethyl)-indole with 2,3-dimethylimidazole-1-sulfonyl azide triflate.
abstract: 3-(2-Bromoethyl)indole reacts with 2,3-dimethylimidazole-1-sulfonyl azide triflate to give an intermediate N-(2,3-dimethylimidazole)-1-sulfonyl aza-spirocyclopropanyloxindole. This reactive species is captured by an alcohol or amine to afford the corresponding aza-spirooxindole sulfonate and sulfonamide.
authors.affiliation: School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu Province 213164, China. shenmh@cczu.edu.cn hdxu@cczu.edu.cn.
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Shen
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.forename: Chu-Han
authors.initials: CH
authors.lastname: Sun
authors.forename: Hua-Dong
authors.initials: HD
authors.lastname: Xu