title: Necrotizing Fasciitis Caused by Cryptococcus gattii.
abstract: Necrotizing fasciitis (NF) is a severe soft-tissue infection that can lead to high morbidity and mortality. The etiology of NF is often polymicrobial. Although rare, fungal organisms have been known to cause NF. Cryptococcus is a fungal infection that may lead to NF. Here we report the case of a 73-year-old man who had diabetes and presented with pain and swelling in the left hand after being bitten by an insect over the dorsum of the hand. Operative débridement revealed NF caused by Cryptococcus gattii. Antifungal medication was started, and the patient underwent multiple débridements of the hand with subsequent skin grafting. Four months later, the hand wound was completely healed. Authors have reported several cases of NF secondary to Cryptococcus neoformans in immunocompromised patients. The emerging C gattii pathogen affects immunocompetent patients. Although the transmission route is mainly respiratory, direct inoculation has been described as well. Ours is the first reported case of NF secondary to C gattii. It is important to consider fungal elements as a source of NF. Appropriate treatment includes aggressive surgical débridement and antifungal therapy.
authors.affiliation: Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore. sean.ho@mohh.com.sg.
authors.forename: Sean Wei Loong
authors.initials: SW
authors.lastname: Ho
authors.forename: Chia-Liang
authors.initials: CL
authors.lastname: Ang
authors.forename: Cristine Szu Lyn
authors.initials: CS
authors.lastname: Ding
authors.forename: Timothy
authors.initials: T
authors.lastname: Barkham
authors.forename: Lam Chuan
authors.initials: LC
authors.lastname: Teoh
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D003453:Cryptococcosis / Q000382:microbiology* / Q000628:therapy; D056285:Cryptococcus gattii / Q000302:isolation & purification*; D003646:Debridement / Q000379:methods*; D019115:Fasciitis, Necrotizing / Q000382:microbiology* / Q000628:therapy; D006801:Humans; D008297:Male
chemical_list: D000935:Antifungal Agents