title: Antibody titers against vaccine and contemporary wild poliovirus type 1 in children immunized with IPV+OPV and young adults immunized with OPV.
abstract: In 2010, a type 1 poliovirus outbreak in Congo with 445 lethal cases was caused by a virus that was neutralized by sera of German adults vaccinated with inactivated polio vaccine with a reduced efficiency. This seroprevalence study was done in two cohorts immunized with other vaccination schedules. Russian children aged 3-6 years immunized with a combination of inactivated and live polio vaccines were reasonably well protected against any wild type poliovirus 1, including the Congolese isolate. Adults aged 20-29 years immunized only with live vaccine were apparently protected against the vaccine strain (92% seropositive), but only 50% had detectable antibodies against the Congo-2010 isolate. Both waning immunity and serological divergence of the Congolese virus could contribute to this result.
authors.affiliation: Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia. Electronic address: alexander_lukashev@hotmail.com.
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Lukashev
authors.affiliation: Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia.
authors.forename: Maria S
authors.initials: MS
authors.lastname: Yarmolskaya
authors.affiliation: Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia.
authors.forename: Elena Yu
authors.initials: EY
authors.lastname: Shumilina
authors.affiliation: Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia.
authors.forename: Daniil A
authors.initials: DA
authors.lastname: Sychev
authors.affiliation: Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia.
authors.forename: Liubov I
authors.initials: LI
authors.lastname: Kozlovskaya
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D003223:Congo; D006801:Humans; D011051:Poliomyelitis / Q000453:epidemiology* / Q000821:virology; D017955:Poliovirus / Q000276:immunology* / Q000302:isolation & purification; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage*; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage*; D012426:Russia; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral
keywords: Herd immunity; Immune escape; Immunization; Poliovirus; Seroprevalence; Vaccine