title: Treatment of elderly patients with metastatic renal cell carcinoma.
abstract: The risk of developing renal cell carcinoma (RCC) increases with age, and given the constant gain in life expectancy of the general population, both localized RCC and metastatic RCC (mRCC) are more frequently observed in the elderly population. The elderly are a heterogeneous group of patients often characterized by the presence of comorbidities, different compliance to treatment and polypharmacy. Here we review the available data with the aim to analyze the safety and efficacy of new targeted therapies (TTs) in elderly mRCC patients. TTs seem to be effective in both older and younger patients, but elderly patients appear to show reduced tolerance to treatments compared to younger patients. Prospective trials are needed to better understand how to manage mRCC in elderly patients.
authors.affiliation: a Academic Unit of Medical Oncology , IRCCS San Martino University Hospital-IST National Cancer Research Institute , Genoa , Italy.|b Department of Medicine , School of Medicine, University of Genoa , Genoa , Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Zanardi
authors.affiliation: c Department of Medical Oncology 1 , Fondazione IRCCS Istituto Nazionale dei Tumori , Milan , Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Grassi
authors.affiliation: a Academic Unit of Medical Oncology , IRCCS San Martino University Hospital-IST National Cancer Research Institute , Genoa , Italy.|b Department of Medicine , School of Medicine, University of Genoa , Genoa , Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Cavo
authors.affiliation: c Department of Medical Oncology 1 , Fondazione IRCCS Istituto Nazionale dei Tumori , Milan , Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Verzoni
authors.affiliation: c Department of Medical Oncology 1 , Fondazione IRCCS Istituto Nazionale dei Tumori , Milan , Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Maggi
authors.affiliation: c Department of Medical Oncology 1 , Fondazione IRCCS Istituto Nazionale dei Tumori , Milan , Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: De Braud
authors.affiliation: a Academic Unit of Medical Oncology , IRCCS San Martino University Hospital-IST National Cancer Research Institute , Genoa , Italy.|b Department of Medicine , School of Medicine, University of Genoa , Genoa , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Boccardo
authors.affiliation: c Department of Medical Oncology 1 , Fondazione IRCCS Istituto Nazionale dei Tumori , Milan , Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Procopio
mesh_terms: D000367:Age Factors; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis
chemical_list: D000970:Antineoplastic Agents
keywords: Renal cell carcinoma; elderly; geriatric oncology; mRCC; targeted therapy