title: The Na(+)-Taurocholate Cotransporting Polypeptide Traffics with the Epidermal Growth Factor Receptor.
abstract: Na(+)-taurocholate cotransporting polypeptide (ntcp) mediates bile acid transport, also serving as the hepatitis B virus receptor. It traffics in vesicles along microtubules, requiring activity of protein kinase C (PKC)ζ for motility. We have now found that the epidermal growth factor receptor (EGFR) is the target of PKCζ activity and that EGFR and ntcp colocalize in vesicles. ntcp-containing vesicles that are not associated with EGFR have reduced microtubule-based motility, consistent with intracellular accumulation and reduced surface expression of ntcp in cells following EGFR knockdown.
authors.affiliation: Marion Bessin Liver Research Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, 10461, USA.
authors.forename: Xintao
authors.initials: X
authors.lastname: Wang
authors.affiliation: Marion Bessin Liver Research Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, 10461, USA.
authors.forename: Pijun
authors.initials: P
authors.lastname: Wang
authors.affiliation: Marion Bessin Liver Research Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, 10461, USA.|Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wang
authors.affiliation: Marion Bessin Liver Research Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, 10461, USA.|Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
authors.forename: John W
authors.initials: JW
authors.lastname: Murray
authors.affiliation: Marion Bessin Liver Research Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, 10461, USA.|Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.|Division of Gastroenterology and Liver Diseases, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, 10461, USA.
authors.forename: Allan W
authors.initials: AW
authors.lastname: Wolkoff
mesh_terms: D045744:Cell Line, Tumor; D011992:Endosomes / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D029363:Organic Anion Transporters, Sodium-Dependent / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism; D021381:Protein Transport; D022142:Secretory Vesicles / Q000378:metabolism; D027981:Symporters / Q000378:metabolism*; D000099221:Protein Kinase C zeta
chemical_list: D066246:ErbB Receptors; D029363:Organic Anion Transporters, Sodium-Dependent; D011493:Protein Kinase C; D027981:Symporters; D000099221:Protein Kinase C zeta; C071908:sodium-bile acid cotransporter
keywords: bile acid; drug transport; endosome; hepatitis B virus (HBV); microtubule