title: Facile synthesis of CdTe@GdS fluorescent-magnetic nanoparticles for tumor-targeted dual-modal imaging.
abstract: Multimodal imaging has made great contribution for diagnosis and therapy of disease since it can provide more effective and complementary information in comparison to any single imaging modality. The design and fabrication of fluorescent-magnetic nanoparticles for multimodal imaging has rapidly developed over the years. Herein, we demonstrate the facile synthesis of GdS coated CdTe nanoparticles (CdTe@GdS NPs) as multimodal agents for fluorescence (FL) and T1-weighted magnetic resonance (MR) imaging. These nanoparticles obtain both prominent fluorescent and paramagnetic properties by coating the GdS shell on the surface of CdTe core via a simple room-temperature route in aqueous solution directly. It is shown that the as-prepared CdTe@GdS NPs have high quantum yield (QY) value of 12% and outstanding longitudinal relaxation rate (r1) of 11.25 mM s(-1), which allow them to be employed as FL/MR dual-modal imaging contrast agents. They also exhibit small particle size of 5 nm, excellent colloidal stability and low cellular toxicity for concentrations up to 750 μg mL(-1). In addition, with the conjugation of folic acid, the nanoparticles were successfully used for tumor-targeted FL/MR dual-modal imaging in vitro and in vivo.
authors.affiliation: College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology (Nankai University), College of Life Science, Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Xiu-Qi
authors.initials: XQ
authors.lastname: Kong
authors.affiliation: The First Central Clinic College, Tianjin Medical University, and Department of Radiology, Tianjin First Central Hospital, 24 Fukang Road, Tianjin 300192, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Li
authors.affiliation: College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Sun
authors.affiliation: The First Central Clinic College, Tianjin Medical University, and Department of Radiology, Tianjin First Central Hospital, 24 Fukang Road, Tianjin 300192, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chai
authors.affiliation: The First Central Clinic College, Tianjin Medical University, and Department of Radiology, Tianjin First Central Hospital, 24 Fukang Road, Tianjin 300192, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Shen
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology (Nankai University), College of Life Science, Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Zhang-Yong
authors.initials: ZY
authors.lastname: Hong
authors.affiliation: College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Xi-Wen
authors.initials: XW
authors.lastname: He
authors.affiliation: College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, 94 Weijin Road, Tianjin 300071, China. Electronic address: wyli@nankai.edu.cn.
authors.forename: Wen-You
authors.initials: WY
authors.lastname: Li
authors.affiliation: College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, 94 Weijin Road, Tianjin 300071, China; National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116011, China.
authors.forename: Yu-Kui
authors.initials: YK
authors.lastname: Zhang
mesh_terms: D000818:Animals; D019187:Cadmium Compounds / Q000008:administration & dosage / Q000138:chemical synthesis*; D002470:Cell Survival / Q000187:drug effects; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000138:chemical synthesis*; D005682:Gadolinium / Q000008:administration & dosage; D006801:Humans; D007624:KB Cells; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008856:Microscopy, Fluorescence / Q000379:methods; D009369:Neoplasms / Q000175:diagnosis*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013440:Sulfides / Q000008:administration & dosage / Q000138:chemical synthesis*; D013691:Tellurium / Q000008:administration & dosage
chemical_list: D019187:Cadmium Compounds; D005456:Fluorescent Dyes; D058185:Magnetite Nanoparticles; D013440:Sulfides; C551149:gadolinium monosulfide; D005682:Gadolinium; D013691:Tellurium; C028337:cadmium telluride
keywords: CdTe@GdS; Dual-modal; Imaging; Nanoparticles; Tumor-targeted