title: Galectin-3 Concentration in Liver Diseases.
abstract: The aim of this study was to evaluate the changes in serum galectin-3 concentration during liver diseases. The results were compared with hyaluronic acid concentration in combination with prothrombin index as a HAPRI index. Serum samples were obtained from 20 healthy volunteers and 109 patients suffering from alcoholic cirrhosis (AC)--57, non-alcoholic cirrhosis (NAC)--30 and toxic hepatitis (HT)--22 patients. Cirrhotic patients were classified according to Child-Pugh scale. Galectin-3 concentration was measured by the chemiluminescent microparticle immunoassay and HAPRI index was calculated using a formula. There was a significant increase in the serum concentration of galectin-3 in patients with AC, NAC and HT, and significant differences between diseases were observed. The mean galectin-3 concentration in AC was significantly higher than that in HT. The serum galectin-3 level differs significantly according to severity of cirrhosis and was the highest in Child-Pugh class C. The sensitivity, specificity, accuracy, positive and negative predictive values and the area under the ROC curve for galectin-3 and HAPRI were high and similar to each other. In conclusion, galectin-3 is a good marker of fibrosis in cirrhosis and toxic hepatitis, which reflects the stage of liver damage, like the HAPRI index.
authors.affiliation: Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Gudowska
authors.affiliation: Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Gruszewska
authors.affiliation: Department of Pediatric Laboratory Diagnostics, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Cylwik
authors.affiliation: Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Anatol
authors.initials: A
authors.lastname: Panasiuk
authors.affiliation: Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Rogalska
authors.affiliation: Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Flisiak
authors.affiliation: Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Szmitkowski
authors.affiliation: Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland chrostek@umb.edu.pl.
authors.forename: Lech
authors.initials: L
authors.lastname: Chrostek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D001798:Blood Proteins; D005260:Female; D005355:Fibrosis / Q000097:blood; D037502:Galectin 3 / Q000097:blood*; D037161:Galectins; D006505:Hepatitis / Q000097:blood* / Q000473:pathology; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D007118:Immunoassay / Q000379:methods; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D037502:Galectin 3; D037161:Galectins; C428445:LGALS3 protein, human; D006820:Hyaluronic Acid