title: Prevalence of Intervillous Thrombi Is Increased in Placentas from Pregnancies Complicated by Diabetes.
abstract: Intervillous thrombus (IVT) is a placental pathology of unclear cause. One possible cause is that IVT protects against fetomaternal transfusion due to trophoblastic disruption. A role for hyperglycemia in trophoblast apoptosis has been suggested. We sought to determine whether placentas from pregnancies complicated by diabetes had an increased incidence of IVT. Medical records of 206 patients with type 1 diabetes (n = 39), type 2 diabetes (n = 37), and gestational diabetes (GDM, n = 130) at the Massachusetts General Hospital were identified. Placental pathology reports were reviewed to determine prevalence of IVT. Gestational and maternal age-matched controls were selected from the pathology archives consisting of placentas examined only for the indication of group B streptococcus screen positivity; controls were confirmed euglycemic and reviewed for IVT. Fisher exact test was used for statistical analysis. An increased incidence of IVT was present in all diabetics (type 1, type 2, and GDM; 32 of 206; 15.5%; P = 0.04) and GDM exclusively (22 of 130; 16.9%; P = 0.03) versus controls (7 of 99; 7.1%). IVT were also increased in patients with type 1 diabetes (4 of 39; 10.3%) and type 2 diabetes (6 of 37; 16.2%) compared to controls (7 of 99; 7.1%), but the results did not attain statistical significance (P = 0.73 and 0.19, respectively). The incidence of IVT was increased in the placentas of patients with diabetes as a group (type 1, type 2, and GDM), and in patients with GDM in particular. This is the first report of an association between diabetes and an increased incidence of placental IVT.
authors.affiliation: 1 Department of Pathology, Massachusetts General Hospital, Boston, MA.
authors.forename: Kristen M
authors.initials: KM
authors.lastname: Basnet
authors.affiliation: 2 Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.
authors.forename: Rhonda
authors.initials: R
authors.lastname: Bentley-Lewis
authors.affiliation: 2 Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Wexler
authors.affiliation: 3 Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR.
authors.forename: Fusun
authors.initials: F
authors.lastname: Kilic
authors.affiliation: 1 Department of Pathology, Massachusetts General Hospital, Boston, MA.
authors.forename: Drucilla J
authors.initials: DJ
authors.lastname: Roberts
mesh_terms: D048909:Diabetes Complications / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D010920:Placenta / Q000473:pathology; D010922:Placenta Diseases / Q000453:epidemiology* / Q000473:pathology; D011247:Pregnancy; D015995:Prevalence; D013927:Thrombosis / Q000453:epidemiology* / Q000473:pathology
keywords: SERT; apoptosis; gestational diabetes; intervillous thrombi; placental pathology; pregestational diabetes; trophoblast