title: Effect of changes in sympathovagal balance on the accuracy of heart rate variability obtained from photoplethysmography.
abstract: Heart rate variability (HRV) obtained using photoplethysmography (PPG), which is also known as pulse rate variability (PRV), has already been used in clinical practice. However, it is uncertain whether PRV reflects changes in autonomic nervous function accurately. The aim of the present study was to evaluate quantitatively the effect of alterations in the sympathovagal balance on the agreement between PRV and HRV from electrocardiographs (ECG). Healthy subjects (male, 26; female, 7; age, 22-25 years old) participated in the present study. Paced respiration with 15 breathes/min and breath holding (apnea) were performed to alter the autonomic nervous states of patients. The changes in the low-to-high frequency power ratio (LF/HF) of HRV indicated that there was a sympathovagal balance shift toward vagal predominance during paced respiration, but toward sympathetic predominance during apnea. The results demonstrated that, during paced respiration, all indices had an acceptable agreement [Bland-Altman ratio (BAr)<0.2] between PRV and HRV, with the exception of LF/HF that had an insufficient agreement (BAr=0.25). All indices had very strong correlations [Pearson's correlation coefficients (CC)>0.99] and PRV had a minor but highly significant (P<0.001) increase for the majority of the variability indices, when compared with HRV. During apnea, the discrepancy of the short-term variability indices between PRV and HRV became sizeable with a BAr>0.3 and a minimum CC of 0.96. In conclusion, a decrease of LF/HF caused a marginal inaccuracy of PRV in the indication of sympathovagal balance, while sympathetic activation increased differences in short-term variability between PRV and HRV.
authors.affiliation: Institute of Biomedical Engineering, School of Life Science and Technology, Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P.R. China ; Postdoctoral Mobile Station of Electronic Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P.R. China ; Solid State Lighting Engineering Research Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P.R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.affiliation: Institute of Biomedical Engineering, School of Life Science and Technology, Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P.R. China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Huang
authors.affiliation: Postdoctoral Mobile Station of Electronic Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P.R. China ; Solid State Lighting Engineering Research Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yun
authors.affiliation: The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P.R. China.
authors.forename: Tian-Jun
authors.initials: TJ
authors.lastname: Chen
authors.affiliation: Institute of Biomedical Engineering, School of Life Science and Technology, Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P.R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Li
keywords: heart rate variability; photoplethysmography; pulse rate variability; sympathetic; vagal balance