title: Sesquiterpenoids and further diterpenoids from the rare Chloranthaceae plant Chloranthus sessilifolius.
abstract: Two new dimeric lindenane-type sesquiterpenoids (1 and 2, named chlorasessilifols A and B, resp.), one new ent-podocarpane-type C17 norditerpenoid (3), and one new ent-torarane-type diterpenoid (4), along with seven known terpenoids, were isolated from the whole plant of Chloranthus sessilifolius. The new structures were established by means of spectroscopic methods and/or observed cotton effects in the circular dichroism spectra. Among the isolates, 3α,7β-dihydroxy-ent-abieta-8,11,13-triene (11) exhibited significant anti-neuroinflammatory activity by inhibiting the nitric oxide production in lipopolysaccharide-stimulated murine BV-2 microglial cells, with an IC50 value of 4.3 μM.
authors.affiliation: a School of Pharmacy, Department of Natural Products Chemistry , Fudan University , Shanghai 201203 , China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Wang
authors.affiliation: a School of Pharmacy, Department of Natural Products Chemistry , Fudan University , Shanghai 201203 , China.
authors.forename: Juan
authors.initials: J
authors.lastname: Xiong
authors.affiliation: b School of Pharmacy, Instrumental Analysis Center , Fudan University , Shanghai 201203 , China.
authors.forename: Choiwan
authors.initials: C
authors.lastname: Lau
authors.affiliation: c School of Pharmacy, Department of Pharmacology , Fudan University , Shanghai 201203 , China.
authors.forename: Li-Long
authors.initials: LL
authors.lastname: Pan
authors.affiliation: a School of Pharmacy, Department of Natural Products Chemistry , Fudan University , Shanghai 201203 , China.
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Hu
mesh_terms: D045784:Abietanes; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D019684:Magnoliopsida / Q000737:chemistry*; D051379:Mice; D017628:Microglia / Q000187:drug effects; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C000607683:3alpha,7beta-dihydroxy-ent-abieta-8,11,13-triene; D045784:Abietanes; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; C000607681:chlorasessilifol A; C000607682:chlorasessilifol B; D009569:Nitric Oxide
keywords: Chloranthaceae; Chloranthus sessilifolius; anti-neuroinflammation; diterpenoids; sesquiterpenoids