title: Long-term Safety and Efficacy of Mexiletine for Patients With Skeletal Muscle Channelopathies.
authors.affiliation: MRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, University College London Institute of Neurology, London, England.
authors.forename: Karen Joan
authors.initials: KJ
authors.lastname: Suetterlin
authors.affiliation: MRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, University College London Institute of Neurology, London, England.
authors.forename: Enrico
authors.initials: E
authors.lastname: Bugiardini
authors.affiliation: University College London Institute of Cardiovascular Science, London, England.
authors.forename: Juan P
authors.initials: JP
authors.lastname: Kaski
authors.affiliation: MRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, University College London Institute of Neurology, London, England.
authors.forename: Jasper M
authors.initials: JM
authors.lastname: Morrow
authors.affiliation: MRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, University College London Institute of Neurology, London, England.
authors.forename: Emma
authors.initials: E
authors.lastname: Matthews
authors.affiliation: MRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, University College London Institute of Neurology, London, England.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Hanna
authors.affiliation: MRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, University College London Institute of Neurology, London, England.
authors.forename: Doreen
authors.initials: D
authors.lastname: Fialho
mesh_terms: D053447:Channelopathies / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D018118:Chloride Channels / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008801:Mexiletine / Q000627:therapeutic use*; D018482:Muscle, Skeletal / Q000473:pathology*; D009154:Mutation / Q000235:genetics; D062553:NAV1.4 Voltage-Gated Sodium Channel / Q000235:genetics; D016032:Randomized Controlled Trials as Topic; D061567:Voltage-Gated Sodium Channel Blockers / Q000627:therapeutic use*
chemical_list: C086321:CLC-1 channel; D018118:Chloride Channels; D062553:NAV1.4 Voltage-Gated Sodium Channel; C106251:SCN4A protein, human; D061567:Voltage-Gated Sodium Channel Blockers; D008801:Mexiletine