title: Calixtyrosol: a Novel Calixarene Based Potent Radical Scavenger.
abstract: The oxidative stress causes many diseases in human, therefore antioxidants have a special position in the medicinal chemistry. Tyrosol is an important antioxidant with a plenty of biological properties. There are many strategies such as clustering single drug units in order to develop new drugs. The cluster effect can increase drug effects relative to single drug unit. Calixtyrosol is the novel cluster of tyrosol that shows a more effective antioxidant activity than single tyrosol. In fact, tyrosol can be considered as 1/4 of the cluster. Four hydroxyethyl moieties have been grafted at the upper rim of the calix[4]arene in all-syn orientation, giving novel agent in the field of antioxidant agents. Free radical scavenging tests were determined by the 2, 2-diphenyl-1-picrylhydrazyl radical in methanol for four antioxidants: calixtyrosol, tyrosol, hydroxytyrosol and 3, 5-di-tert-buty l-4-hydroxytoluene to compare their antioxidant activity. Free radical scavenging test showed that calixtyrosol has enhanced antioxidant activity in comparison to the corresponding single tyrosol unit (> 5 fold), it has even more active than the other test antioxidants (2 fold). Presumably, it is attributed to tethering and arraying of four impacted tyrosol units, which make a synergistic effect in interactions with radicals for creating effective radical scavenging activity. This method is in debt of synergistic effect, tethering and arraying of single units in the cluster structure.
authors.affiliation: Health Technology Incubator Center, Urmia University of Medical Science, Urmia, Iran.
authors.forename: Fazel
authors.initials: F
authors.lastname: Nasuhi Pur
authors.affiliation: Department of Chemistry, Faculty of Science, Urmia University, Urmia, Iran.
authors.forename: Karim
authors.initials: K
authors.lastname: Akbari Dilmaghani
keywords: Antioxidant; Calixarene; Calixtyrosol; Radical scavenging; Tyrosol