title: Association between NAD(P)H oxidase p22phox gene variants and acute myocardial infarction in a Han Chinese population.
abstract: BACKGROUND
  We investigated the association between five selected single-nucleotide polymorphisms (rs12933505, rs3180279, rs3794264, rs4673, rs1049255) in the NAD(P)H p22phox gene and acute myocardial infarction (AMI) as well as severity of coronary artery stenosis in a Han Chinese population.
  
  
  METHODS
  A total of 168 patients with AMI and 138 healthy controls were recruited. The TaqMan allelic discrimination assay was used to genotype five single-nucleotide polymorphisms.
  
  
  RESULTS
  The frequency of the rs1049255 G allele was significantly lower in patients with AMI than in controls (p = 0.022). Compared with subjects with an AA genotype, subjects with a GG or AG genotype had a lower risk of AMI [multivariate-adjusted odds ratio (OR), 0.53; 95 % CI, 0.29-0.95; p = 0.031). Subjects with the GG and AG genotypes of rs1049255 showed a decreased susceptibility for triple-vessel disease (TVD) as compared with controls (multivariate-adjusted OR, 0.43; 95 % CI, 0.19-0.98; p = 0.042). Multiple logistic regression analysis revealed that the rs1049255G variant was an independent protective factor for AMI/TVD.
  
  
  CONCLUSIONS
  The results suggest there is an association between the p22phox rs1049255 polymorphism with the prevalence of AMI and the severity of coronary artery stenosis in the Han Chinese population.
authors.affiliation: Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, 223300, Huai'an, Jiangsu, P.R. China.
authors.forename: H
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, 223300, Huai'an, Jiangsu, P.R. China.
authors.forename: S
authors.initials: S
authors.lastname: Ma
authors.affiliation: Department of Nephrology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, P.R. China.
authors.forename: F-Y
authors.initials: FY
authors.lastname: Tang
authors.affiliation: Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, 223300, Huai'an, Jiangsu, P.R. China.
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Nephrology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, P.R. China.
authors.forename: H
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Nephrology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, P.R. China.
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratory, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, P.R. China.
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, P.R. China.
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, 223300, Huai'an, Jiangsu, P.R. China. xie_xiongwei@163.com.
authors.forename: X
authors.initials: X
authors.lastname: Xie
mesh_terms: D017677:Age Distribution; D015415:Biomarkers / Q000032:analysis; D002681:China / Q000453:epidemiology / Q000208:ethnology; D023921:Coronary Stenosis / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D019255:NADPH Oxidases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity; D017678:Sex Distribution
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; D019255:NADPH Oxidases; C086986:CYBA protein, human
keywords: Coronary artery disease; Gene polymorphism; Myocardial infarction; NAD(P)H oxidase; p22phox gene