title: Pharmacological targeting of ion channels for cancer therapy: In vivo evidences.
abstract: Since the discovery of the participation of various ion channels in the regulation of cell proliferation and programmed cell death two decades ago, the field exploring ion channel function in relation to cancer has undergone rapid development. Although the mechanisms accounting for the impact of ion channel modulators on cancer growth have not been fully clarified in all cases, numerous in vivo experiments targeting diverse ion channels in various cancer models illustrate the great potentiality of this approach and promote ion channels to the class of oncological targets. In the present review we give an updated overview of the field and critically discuss the promising results obtained in pre-clinical models using specific pharmacological modulators of calcium, sodium, potassium and anion-permeable ion channels, whose expression is often altered in tumor cells and tissues. The most, especially critical issues are specificity of action and side-effects. Interestingly, some of the most potent drugs are natural products, and several of the active compounds are already used in the clinic for other purposes. In these latter cases involving drug repositioning we may expect a faster progression from preclinical to clinical studies. This article is part of a Special Issue entitled: Calcium and Cell Fate. Guest Editors: Jacques Haiech, Claus Heizmann, Joachim Krebs, Thierry Capiod and Olivier Mignen.
authors.affiliation: Department of Biology, University of Padua, Padua, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Leanza
authors.affiliation: Department of Biology, University of Padua, Padua, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Managò
authors.affiliation: Department of Biomedical Sciences, University of Padua, Padua, Italy; CNR Institute of Neuroscience, Padua, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Zoratti
authors.affiliation: Department of Molecular Biology, University of Duisburg-Essen, Essen, Germany.
authors.forename: Erich
authors.initials: E
authors.lastname: Gulbins
authors.affiliation: Department of Biology, University of Padua, Padua, Italy; CNR Institute of Neuroscience, Padua, Italy. Electronic address: ildi@civ.bio.unipd.it.
authors.forename: Ildiko
authors.initials: I
authors.lastname: Szabo
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007473:Ion Channels / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D026902:Potassium Channel Blockers / Q000627:therapeutic use*; D026941:Sodium Channel Blockers / Q000627:therapeutic use*
chemical_list: D002121:Calcium Channel Blockers; D007473:Ion Channels; D026902:Potassium Channel Blockers; D026941:Sodium Channel Blockers
keywords: Anion channels; Calcium-permeable channels; In vivo cancer models; Pharmacological targeting; Potassium channels; Sodium channels