title: Genotype/allelic combinations as potential predictors of myocardial infarction.
abstract: In order to find new informative predictors of myocardial infarction, we performed an analysis of genotype frequencies of polymorphic markers of SELE (rs2076059, 3832T > C), SELP (rs6131, S290 N), SELL (rs1131498, F206L), ICAM1 (rs5498, K469E), VCAM1 (rs3917010, c.928 + 420A > C), PECAM1 (rs668, V125L), VEGFA (rs35569394, -2549(18)I/D), CCL2 (rs1024611, -2518A > G), NOS3 (rs1799983, E298D), and DDAH1 (rs669173, c.303 + 30998A > G) genes in the group of Russian men with myocardial infarction (N = 315) and the control group of corresponding ethnicity, gender, and age (N = 286). Using Markov chain Monte-Carlo method (APSampler), we found genotype combinations associated with increased and decreased risk of myocardial infarction. The most significant associations were detected for PECAM1*V/V + DDAH1*C (OR = 4.17 CI 1.56-11.15 Pperm = 0.005) SELE*C + VEGFA*I + CCL2*G + VCAM1*A + NOS3*D (OR = 2.74 CI 1.66-4.52 Pperm = 2.09 × 10(-5)), and VEGFA*D/D + CCL2*A + DDAH1*C (OR = 0.44 CI 0.28-0.7 Pperm = 7.89 × 10(-5)) genotype combinations.
authors.affiliation: Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russian Federation.
authors.forename: Timur R
authors.initials: TR
authors.lastname: Nasibullin
authors.affiliation: Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russian Federation.
authors.forename: Yanina R
authors.initials: YR
authors.lastname: Timasheva
authors.affiliation: Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russian Federation.
authors.forename: Regina I
authors.initials: RI
authors.lastname: Sadikova
authors.affiliation: Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russian Federation.
authors.forename: Ilsiyar A
authors.initials: IA
authors.lastname: Tuktarova
authors.affiliation: Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russian Federation.
authors.forename: Vera V
authors.initials: VV
authors.lastname: Erdman
authors.affiliation: Republic Centre for Cardiology, Ufa, Russian Federation.
authors.forename: Irina E
authors.initials: IE
authors.lastname: Nikolaeva
authors.affiliation: Department of Medical Physics and Biophysics, Faculty of Medicine, Pavol Jozef Safarik University, Trieda SNP 1, 040 11, Kosice, Slovak Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Sabo
authors.affiliation: Department of Medical Physics and Biophysics, Faculty of Medicine, Pavol Jozef Safarik University, Trieda SNP 1, 040 11, Kosice, Slovak Republic. peter.kruzliak@savba.sk.|2nd Department of Internal Medicine, Faculty of Medicine, Masaryk University, Brno, Czech Republic. peter.kruzliak@savba.sk.|Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic. peter.kruzliak@savba.sk.
authors.forename: Peter
authors.initials: P
authors.lastname: Kruzliak
authors.affiliation: Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russian Federation.
authors.forename: Olga E
authors.initials: OE
authors.lastname: Mustafina
mesh_terms: D000328:Adult; D000581:Amidohydrolases / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000208:ethnology / Q000235:genetics*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012426:Russia
chemical_list: D019408:Platelet Endothelial Cell Adhesion Molecule-1; D000581:Amidohydrolases; C059999:dimethylargininase
keywords: Genetic testing; Myocardial infarction; Risk prediction