title: Distinct Functions of Neutrophil in Cancer and Its Regulation.
abstract: Neutrophils are the most abundant of all white blood cells in the human circulation and are usually associated with inflammation and with fighting infections. In recent years the role immune cells play in cancer has been a matter of increasing interest. In this context the function of neutrophils is controversial as neutrophils were shown to possess both tumor promoting and tumor limiting properties. Here we provide an up-to-date review of the pro- and antitumor properties neutrophils possess as well as the environmental cues that regulate these distinct functions.
authors.affiliation: Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel.
authors.forename: Zvi
authors.initials: Z
authors.lastname: Granot
authors.affiliation: Translational Oncology, Internal Medicine II, University Hospital, Tuebingen, Otfried-Mueller-Street 10, 72076 Tuebingen, Germany.
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Jablonska
mesh_terms: D000818:Animals; D002465:Cell Movement; D016764:Cell Polarity; D016207:Cytokines / Q000502:physiology; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007372:Interferons / Q000502:physiology; D008213:Lymphocyte Activation; D009369:Neoplasms / Q000276:immunology*; D018919:Neovascularization, Physiologic; D009504:Neutrophils / Q000502:physiology*; D019139:Tumor Escape; D059016:Tumor Microenvironment
chemical_list: D016207:Cytokines; D007372:Interferons