title: Three new xanthones from the leaves of Garcinia lancilimba.
abstract: Three new prenylated xanthones, garcinexanthones G-I (1-3), together with fifteen known ones (4-18) were identified from the leaves of Garcinia lancilimba. Their structures were determined by extensive spectroscopic analyses. Most of the compounds exhibited inhibitory effects against HL-60 (human leukemia), A549 (human lung cancer), and MCF-7 (human breast cancer) cell lines. Among them, compounds 7, 17, and 13 exhibited the most pronounced growth inhibitory activity against HL-60, A549, and MCF-7 cell lines with GI50 values of 1.68, 4.88, and 6.28 μM, respectively.
authors.affiliation: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China.
authors.forename: Yating
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China.
authors.forename: Dahong
authors.initials: D
authors.lastname: Li
authors.affiliation: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China.
authors.forename: Cuicui
authors.initials: C
authors.lastname: Jia
authors.affiliation: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Xue
authors.affiliation: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Bai
authors.affiliation: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China. lzl1030@hotmail.com.
authors.forename: Zhanlin
authors.initials: Z
authors.lastname: Li
authors.affiliation: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China. huimhua@163.com.
authors.forename: Huiming
authors.initials: H
authors.lastname: Hua
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D005260:Female; D029760:Garcinia / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D061986:MCF-7 Cells; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D054876:Prenylation; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D044004:Xanthones; C000611363:garcinexanthone G; C000611364:garcinexanthone H; C000611365:garcinexanthone I
keywords: Antiproliferative activity; Garcinexanthones G−I; Garcinia lancilimba; Xanthones