title: Reliable and Accurate Calcium Volume Measurement in Coronary Artery Using Intravascular Ultrasound Videos.
abstract: Quantitative assessment of calcified atherosclerotic volume within the coronary artery wall is vital for cardiac interventional procedures. The goal of this study is to automatically measure the calcium volume, given the borders of coronary vessel wall for all the frames of the intravascular ultrasound (IVUS) video. Three soft computing fuzzy classification techniques were adapted namely Fuzzy c-Means (FCM), K-means, and Hidden Markov Random Field (HMRF) for automated segmentation of calcium regions and volume computation. These methods were benchmarked against previously developed threshold-based method. IVUS image data sets (around 30,600 IVUS frames) from 15 patients were collected using 40 MHz IVUS catheter (Atlantis® SR Pro, Boston Scientific®, pullback speed of 0.5 mm/s). Calcium mean volume for FCM, K-means, HMRF and threshold-based method were 37.84 ± 17.38 mm(3), 27.79 ± 10.94 mm(3), 46.44 ± 19.13 mm(3) and 35.92 ± 16.44 mm(3) respectively. Cross-correlation, Jaccard Index and Dice Similarity were highest between FCM and threshold-based method: 0.99, 0.92 ± 0.02 and 0.95 + 0.02 respectively. Student's t-test, z-test and Wilcoxon-test are also performed to demonstrate consistency, reliability and accuracy of the results. Given the vessel wall region, the system reliably and automatically measures the calcium volume in IVUS videos. Further, we validated our system against a trained expert using scoring: K-means showed the best performance with an accuracy of 92.80%. Out procedure and protocol is along the line with method previously published clinically.
authors.affiliation: Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Araki
authors.affiliation: Department of Electrical Engineering, NIT Raipur, Chhattisgarh, India.|Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA, USA.
authors.forename: Sumit K
authors.initials: SK
authors.lastname: Banchhor
authors.affiliation: Department of Electrical Engineering, NIT Raipur, Chhattisgarh, India.|Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA, USA.
authors.forename: Narendra D
authors.initials: ND
authors.lastname: Londhe
authors.affiliation: Cardiovascular Medicine, National Center for Global Health and Medicine, Tokyo, Japan.
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Ikeda
authors.affiliation: Department MAIA, Computer Vision Centre, Cerdanyola del Vallés, University of Barcelona, Barcelona, Spain.
authors.forename: Petia
authors.initials: P
authors.lastname: Radeva
authors.affiliation: Department of Electrical Engineering, NIT Raipur, Chhattisgarh, India.|Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA, USA.
authors.forename: Devarshi
authors.initials: D
authors.lastname: Shukla
authors.affiliation: Department of Radiology, University of Cagliari, Cagliari, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Saba
authors.affiliation: Department of Radiology, University of Cagliari, Cagliari, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Balestrieri
authors.affiliation: Vascular Screening and Diagnostic Centre, London, UK.|Vascular Diagnostic Centre, University of Cyprus, Nicosia, Cyprus.
authors.forename: Andrew
authors.initials: A
authors.lastname: Nicolaides
authors.affiliation: CorVasc Vascular Laboratory, 8433 Harcourt Rd #100, Indianapolis, IN, USA.
authors.forename: Shoaib
authors.initials: S
authors.lastname: Shafique
authors.affiliation: UC Davis Vascular Centre, University of California, Davis, CA, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Laird
authors.affiliation: Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA, USA. Jasjit.Suri@atheropoint.com.|Point-of-Care Devices, Global Biomedical Technologies, Inc., Roseville, CA, USA. Jasjit.Suri@atheropoint.com.|Department of Electrical Engineering, University of Idaho (Affl.), Moscow, ID, USA. Jasjit.Suri@atheropoint.com.
authors.forename: Jasjit S
authors.initials: JS
authors.lastname: Suri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000032:analysis*; D003324:Coronary Artery Disease / Q000175:diagnosis*; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D017143:Fuzzy Logic; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D014463:Ultrasonography; D061205:Vascular Calcification / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D002118:Calcium
keywords: Accuracy; Atherosclerosis; Coronary arteries; IVUS; Interventional cardiology; Performance; Reliability; Soft computing; calcium volume