title: A plasmonic chip-based bio/chemical hybrid sensing system for the highly sensitive detection of C-reactive protein.
abstract: A synthetic polymer ligand-grafted plasmonic chip was fabricated and demonstrated a highly sensitive detection of C-reactive protein (CRP) by grating-coupled surface plasmon field-enhanced fluorescence. Poly(2-methacryloyloxyethyl-phosphorylcholine) was used as a CRP-specific polymer ligand layer and was grafted onto the plasmonic chip using surface-initiated controlled/living radical polymerization (limit of detection: ca. 10 pM).
authors.affiliation: Graduate School of Engineering, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan. takeuchi@gold.kobe-u.ac.jp.
authors.forename: Ryo
authors.initials: R
authors.lastname: Matsuura
authors.forename: Keiko
authors.initials: K
authors.lastname: Tawa
authors.forename: Yukiya
authors.initials: Y
authors.lastname: Kitayama
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis*; D006801:Humans; D008024:Ligands; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D008024:Ligands; D011109:Polymethacrylic Acids; C115766:poly(2-methacryloyloxyethyl-phosphorylcholine); D010767:Phosphorylcholine; D002097:C-Reactive Protein