title: Effects of Experimental Coma on the Expression of Bcl-2 Protein and Caspases 3 and 9 in Rat Brain.
abstract: We performed immunohistochemical analysis of the expression of caspases 3, 9 and bcl-2 protein in rat brain at various terms after administration of LD50 of sodium thiopental. Expression of the specified apoptosis markers was found in the sensorimotor cortex and hippocampus (dentate gyrus and CA2 region).
authors.affiliation: Laboratory of Genetics of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. svetsov83@mail.ru.|Laboratory of Biochemical Toxicology and Pharmacology, Institute of Toxicology, Federal Medical-Biological Agency of Russia, St. Petersburg, Russia. svetsov83@mail.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Shvetsov
authors.affiliation: Laboratory of Biochemical Toxicology and Pharmacology, Institute of Toxicology, Federal Medical-Biological Agency of Russia, St. Petersburg, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Dyuzhikova
authors.affiliation: Laboratory of Biochemical Toxicology and Pharmacology, Institute of Toxicology, Federal Medical-Biological Agency of Russia, St. Petersburg, Russia.
authors.forename: Yu N
authors.initials: YN
authors.lastname: Savenko
authors.affiliation: Laboratory of Genetics of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: E G
authors.initials: EG
authors.lastname: Batotsyrenova
authors.affiliation: Laboratory of Genetics of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Kashuro
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D053148:Caspase 3 / Q000378:metabolism*; D053453:Caspase 9 / Q000378:metabolism*; D003128:Coma / Q000378:metabolism*; D018891:Dentate Gyrus / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D051381:Rats
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D053148:Caspase 3; D053453:Caspase 9
keywords: apoptosis; bcl-2; caspase 3; caspase 9; sodium thiopental