title: A comparison of dexmedetomidine versus propofol during drug-induced sleep endoscopy in sleep apnea patients.
abstract: OBJECTIVE
  In this study, we compared the effects of propofol and dexmedetomidine on the upper airway collapse pattern and cardiopulmonary parameters of patients with obstructive sleep apnea (OSA) undergoing drug-induced sleep endoscopy (DISE).
  
  
  METHODS
  Prospective, single center, observational study
  
  
  METHODS
  The 50 patients with OSA underwent 30 minutes of DISE on 2 different days, the first time with propofol target-controlled infusion (TCI) and the second time with dexmedetomidine TCI. Both the characteristics of upper airway obstruction and cardiopulmonary parameters in response to the depth of sedation achieved with each drug were evaluated.
  
  
  RESULTS
  The results obtained with propofol and dexmedetomidine DISE were in excellent agreement for all sites of obstruction irrespective of the depth of sedation. Although partial or total obstruction at all areas was consistently observed using both drugs, the degree of upper airway narrowing was slightly lower with dexmedetomidine than with propofol. However, the percentage of patients with a greater than 20% change in blood pressure and heart rate compared to baseline was significantly higher in response to propofol than to dexmedetomidine (P = 0.003 and P < 0.001, respectively). Minimal oxygen saturation was significantly lower in DISE with propofol than with dexmedetomidine (P = 0.004). The percentage of patients with oxygen saturation less than 90% or 80% during DISE was significantly higher in response to propofol than to dexmedetomidine (P = 0.032 and P < 0.001, respectively).
  
  
  CONCLUSIONS
  The DISE findings achieved with propofol and dexmedetomidine were in excellent agreement. However, during DISE, dexmedetomidine provided greater hemodynamic stability and less respiratory depression than propofol.
  
  
  METHODS
  4. Laryngoscope, 126:763-767, 2016.
authors.affiliation: Department of Otorhinolaryngology and Biomedical Research Institute, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Republic of Korea.
authors.forename: Byung-Woo
authors.initials: BW
authors.lastname: Yoon
authors.affiliation: Department of Anesthesia and Pain Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Republic of Korea.
authors.forename: Jeong-Min
authors.initials: JM
authors.lastname: Hong
authors.affiliation: Department of Otorhinolaryngology and Biomedical Research Institute, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Republic of Korea.
authors.forename: Sung-Lyong
authors.initials: SL
authors.lastname: Hong
authors.affiliation: Department of Otorhinolaryngology, Busan St. Mary's Medical Center, Busan, Republic of Korea.
authors.forename: Soo-Kweon
authors.initials: SK
authors.lastname: Koo
authors.affiliation: Department of Otorhinolaryngology and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
authors.forename: Hwan-Jung
authors.initials: HJ
authors.lastname: Roh
authors.affiliation: Department of Otorhinolaryngology and Biomedical Research Institute, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Republic of Korea.
authors.forename: Kyu-Sup
authors.initials: KS
authors.lastname: Cho
mesh_terms: D000328:Adult; D058109:Airway Management / Q000379:methods; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D015331:Cohort Studies; D020927:Dexmedetomidine / Q000008:administration & dosage*; D004724:Endoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage*; D011446:Prospective Studies; D018570:Risk Assessment; D012890:Sleep / Q000187:drug effects*; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018686:Anesthetics, Intravenous; D020927:Dexmedetomidine; D015742:Propofol
keywords: Drug-induced sleep endoscopy; dexmedetomidine; obstructive; propofol; sleep apnea; snoring