title: Krüppel-like factor 17, a novel tumor suppressor: its low expression is involved in cancer metastasis.
abstract: Krüppel-like factor (KLF) family is highly conserved zinc finger transcription factors that regulate cell proliferation, differentiation, apoptosis, and migration. KLF17 is a member of the KLF family. Recent studies have demonstrated that KLF17 low expression and inactivation are caused by microRNA, gene mutation, and loss of heterozygosity in human tumors, which participates in tumor progression. KLF17 low expression increases cancer metastatic viability; its mechanism is that low KLF17 mediates epithelial-mesenchymal transition (EMT) through regulating EMT-related genes expression; the reduced-KLF17 also increases cancer metastasis though upregulating inhibitor of DNA binding 1 (ID1). Additionally, mutant p53 proteins are capable of developing a complex with KLF17, which mediate the depletion of KLF17 inhibiting EMT gene transcription and increases cancer metastasis. KLF17 downregulation also mediates the activation of TGF-β pathway.
authors.affiliation: Medical Research Center and Clinical Laboratory, Zhuhai People's Hospital and Zhuhai Hospital of Jinan University, 79 Kangning Road, Zhuhai, 519000, Guangdong, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Metallurgical Science and Engineering, Central South University, 21# Lushan South Road, Changsha, 410083, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Tang
authors.affiliation: Medical Research Center and Clinical Laboratory, Zhuhai People's Hospital and Zhuhai Hospital of Jinan University, 79 Kangning Road, Zhuhai, 519000, Guangdong, China. tangfaqing33@hotmail.com.
authors.forename: Faqing
authors.initials: F
authors.lastname: Tang
mesh_terms: D000818:Animals; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D014157:Transcription Factors / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: C510638:KLF17 protein, human; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins
keywords: Cancer metastasis; Epithelial-mesenchymal transition; Krüppel-like factor 17; TGF-β pathway; p53 pathway