title: The use of nanocrystalline and two other forms of calcium sulfate in the treatment of infrabony defects: A clinical and radiographic study.
abstract: BACKGROUND
  Calcium sulphate(CS) is one of the oldest alloplastic graft materials used because of its biocompatibility, handling characteristics, porosity, different rates of dissolution, chemico-physical resemblance to bone mineral, ability to induce release of growth factors and potentially unlimited supply at a modest cost. Aim of the study was to evaluate the efficacy of 3 forms of calcium sulphate i.e. Nanogen (nCS)(+), BoneGen(+) and Dentogen(+) in treatment of infrabony defects and to compare their efficacy as bone grafting substitutes.
  
  
  METHODS
  A prospective randomized, double blind controlled study was conducted on 45 sites from 16 subjects having Moderate to Advanced Periodontitis who were divided into 3 groups i.e. Group I (Nanogen), Group II (Dentogen) and Group III (BoneGen) clinical along with radiographic measurements were taken at baseline, 6 and 12 months postoperatively.
  
  
  RESULTS
  There was no significant inter-group difference in mean clinical attachment level (CAL) values at different time intervals whereas Intra-group changes in CAL at 6 and 12 months as compared to baseline were significant statistically. In Group I, changes in CAL between 6 and 12 months were found to be statistically significant in comparison with Group II and III.
  
  
  CONCLUSIONS
  Both Nanogen and BoneGen TR can be considered valuable options in the treatment of infra-bony periodontal defects. The faster degradation of Dentogen may negatively affect its bone regeneration potential.
authors.affiliation: Department of Periodontology and Oral Implantology, DAV (C) Dental College and Hospital, Yamunanagar, Haryana, India.
authors.forename: Nymphea
authors.initials: N
authors.lastname: Pandit
authors.affiliation: Department of Periodontology and Oral Implantology, DAV (C) Dental College and Hospital, Yamunanagar, Haryana, India.
authors.forename: Aditi
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Department of Periodontology and Oral Implantology, H.S Judge Institute of Dental Sciences, Chandigarh, India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Jain
authors.affiliation: Department of Periodontology and Oral Implantology, DAV (C) Dental College and Hospital, Yamunanagar, Haryana, India.
authors.forename: Deepika
authors.initials: D
authors.lastname: Bali
authors.affiliation: Department of Periodontology and Oral Implantology, DAV (C) Dental College and Hospital, Yamunanagar, Haryana, India.
authors.forename: Rajvir
authors.initials: R
authors.lastname: Malik
authors.affiliation: Department of Periodontology and Oral Implantology, DAV (C) Dental College and Hospital, Yamunanagar, Haryana, India.
authors.forename: Shalini
authors.initials: S
authors.lastname: Gugnani
keywords: Bone graft; calcium sulphate; nanocrystalline; periodontal disease