title: Three-Component Coupling Involving Arynes, Aromatic Tertiary Amines, and Aldehydes via Aryl-Aryl Amino Group Migration.
abstract: The transition-metal-free multicomponent coupling of arynes, aromatic tertiary amines, and aldehydes proceeding via the aryl to aryl amino group migration has been demonstrated. This protocol allows rapid access to ortho-functionalized tertiary amines in moderate to good yields. Moreover, activated ketones can also be used as the aldehyde component in the present reaction. The similarity of the aryl-aryl tertiary amino group migration with the Smiles rearrangement is striking.
authors.affiliation: Organic Chemistry Division and ‡Centre for Materials Characterization, CSIR-National Chemical Laboratory (CSIR-NCL) , Dr. Homi Bhabha Road, Pune 411008, India.
authors.forename: Sachin Suresh
authors.initials: SS
authors.lastname: Bhojgude
authors.affiliation: Organic Chemistry Division and ‡Centre for Materials Characterization, CSIR-National Chemical Laboratory (CSIR-NCL) , Dr. Homi Bhabha Road, Pune 411008, India.
authors.forename: Dnyaneshwar R
authors.initials: DR
authors.lastname: Baviskar
authors.affiliation: Organic Chemistry Division and ‡Centre for Materials Characterization, CSIR-National Chemical Laboratory (CSIR-NCL) , Dr. Homi Bhabha Road, Pune 411008, India.
authors.forename: Rajesh G
authors.initials: RG
authors.lastname: Gonnade
authors.affiliation: Organic Chemistry Division and ‡Centre for Materials Characterization, CSIR-National Chemical Laboratory (CSIR-NCL) , Dr. Homi Bhabha Road, Pune 411008, India.
authors.forename: Akkattu T
authors.initials: AT
authors.lastname: Biju