title: Electrochemical comparison and biological performance of a new CoCrNbMoZr alloy with commercial CoCrMo alloy.
abstract: A new CoCrNbMoZr alloy, with Nb and Zr content is characterized from the point of view of surface features, corrosion resistance and biological performance in order to be proposed as dental restorative material. Its properties are discussed in comparison with commercial Heraenium CE alloy based on Co, Cr and Mo as well. The microstructure of both alloys was revealed by scanning electron microscopy (SEM). The composition and thickness of the alloy native passive films were identified by X-ray photoelectron spectroscopy (XPS). The surface characteristics were analyzed by atomic force microscopy (AFM) and contact angle techniques. The quantity of ions released from alloys in artificial saliva was evaluated with inductively coupled plasma-mass spectroscopy (ICP-MS) measurements. The electrochemical stability was studied in artificial Carter-Brugirard saliva, performing open circuit potentials, polarization resistances and corrosion currents and rates. The biological performance of the new alloy was tested in vitro in terms of human adipose stem cells (hASCs) morphology, viability and proliferation status. The new alloy is very resistant to the attack of the aggressive ions from the artificial saliva. The surface properties, the roughness and wettabiliy sustain the cell behavior. The comparison of the new alloy behavior with that of existing commercial CoCrMo alloy showed the superior properties of the new metallic biomaterial.
authors.affiliation: Department of General Chemistry, University Politehnica Bucharest, Spl. Independentei 313, 060042 Bucharest, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Andrei
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Spl. Independentei, Bucharest 050095, Romania; Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Rebreanu, 310414 Arad, Romania.
authors.forename: B
authors.initials: B
authors.lastname: Galateanu
authors.affiliation: Department of General Chemistry, University Politehnica Bucharest, Spl. Independentei 313, 060042 Bucharest, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Hudita
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Spl. Independentei, Bucharest 050095, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Costache
authors.affiliation: Institute of Physical Chemistry "Ilie Murgulescu" of Romanian Academy, Spl. Independentei 202, 060021 Bucharest, Romania.
authors.forename: P
authors.initials: P
authors.lastname: Osiceanu
authors.affiliation: Institute of Physical Chemistry "Ilie Murgulescu" of Romanian Academy, Spl. Independentei 202, 060021 Bucharest, Romania.
authors.forename: J M
authors.initials: JM
authors.lastname: Calderon Moreno
authors.affiliation: Institute of Physical Chemistry "Ilie Murgulescu" of Romanian Academy, Spl. Independentei 202, 060021 Bucharest, Romania. Electronic address: sidrob@chimfiz.icf.ro.
authors.forename: S I
authors.initials: SI
authors.lastname: Drob
authors.affiliation: Department of General Chemistry, University Politehnica Bucharest, Spl. Independentei 313, 060042 Bucharest, Romania.
authors.forename: I
authors.initials: I
authors.lastname: Demetrescu
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism*; D000497:Alloys / Q000737:chemistry / Q000494:pharmacology; D055664:Electrochemical Techniques; D006801:Humans; D008422:Materials Testing; D019216:Metals, Heavy / Q000737:chemistry / Q000494:pharmacology; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*
chemical_list: D000497:Alloys; D019216:Metals, Heavy
keywords: Adipose stem cells (hASCs); Biocompatibility; Corrosion resistance; Microstructure; New CoCrNbMoZr alloy; Surface features