title: Vaccine Failures in Patients Properly Vaccinated with 13-Valent Pneumococcal Conjugate Vaccine in Catalonia, a Region with Low Vaccination Coverage.
abstract: Vaccine failures occurring with 13-valent pneumococcal conjugate vaccine (PCV13) in 3 pediatric hospitals in Barcelona (2012-2013) are described. PCV13 vaccine failure was defined as the occurrence of an invasive pneumococcal infection in children properly vaccinated by PCV13. Among 84 patients with invasive pneumococcal infection, 32 had received at least one dose of PCV13. Seventeen of them had invasive pneumococcal infection produced by a PCV13 serotype. Among those, 9 patients were considered to have a PCV13 vaccine failure. Serotype 3 was isolated in 6 patients, serotype 19A in 2 and serotype 6B in 1.
authors.affiliation: From the *Pediatrics, Hospital Vall d'Hebron, Barcelona, Spain; †Pediatrics, Hospital Sant Joan de Déu, Barcelona, Spain; ‡Pediatrics, Hospital de Nens, Barcelona, Spain; §Departament de Salut, Agència de Salut Pública de Catalunya, Barcelona, Spain; ¶Microbiology, Hospital Vall d'Hebron, Barcelona, Spain; ‖Preventive Medicine, Hospital Vall d'Hebron, Barcelona, Spain; **CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; ††Molecular Microbiology, Hospital Sant Joan de Déu, Barcelona, Spain; and ‡‡ Departament de Salut Pública, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Moraga-Llop
authors.forename: Juan-Jose
authors.initials: JJ
authors.lastname: Garcia-Garcia
authors.forename: Alvaro
authors.initials: A
authors.lastname: Díaz-Conradi
authors.forename: Pilar
authors.initials: P
authors.lastname: Ciruela
authors.forename: Johanna
authors.initials: J
authors.lastname: Martínez-Osorio
authors.forename: Sebastià
authors.initials: S
authors.lastname: González-Peris
authors.forename: Sergi
authors.initials: S
authors.lastname: Hernández
authors.forename: Mariona Fernández
authors.initials: MF
authors.lastname: de Sevilla
authors.forename: Sonia
authors.initials: S
authors.lastname: Uriona
authors.forename: Conchita
authors.initials: C
authors.lastname: Izquierdo
authors.forename: Laura
authors.initials: L
authors.lastname: Selva
authors.forename: Magda
authors.initials: M
authors.lastname: Campins
authors.forename: Gemma
authors.initials: G
authors.lastname: Codina
authors.forename: Joan
authors.initials: J
authors.lastname: Batalla
authors.forename: Cristina
authors.initials: C
authors.lastname: Esteva
authors.forename: Àngela
authors.initials: À
authors.lastname: Domínguez
authors.forename: Carmen
authors.initials: C
authors.lastname: Muñoz-Almagro
mesh_terms: D006801:Humans; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D013030:Spain / Q000453:epidemiology; D013296:Streptococcus pneumoniae / Q000276:immunology*; D017211:Treatment Failure; D014611:Vaccination
chemical_list: C538862:13-valent pneumococcal vaccine; D022242:Pneumococcal Vaccines