title: Analysis of mitochondrial DNA heteroplasmic mutations A1555G, C3256T, T3336C, С5178А, G12315A, G13513A, G14459A, G14846А and G15059A in CHD patients with the history of myocardial infarction.
abstract: The present study was undertaken in order to advance our earlier studies directed to define genetic risk of atherosclerotic vascular lesion development on a base on the analysis of sets of mutational load relevant to the mitochondrial genome mutations. A comparative evaluation of the two study participants' populations (that included coronary heart disease (CHD) patients who underwent myocardial infarction and apparently healthy donors with no clinical manifestations of coronary heart disease) on heteroplasmy levels of nine mutations of the mitochondrial genome (A1555G, C3256T, T3336C, С5178А, G12315A, G13513A, G14459A, G14846А and G15059A) that were shown previously to be associated with risk factors for atherosclerosis was performed. Close associations with the risk of cardiovascular disease were confirmed for mutation C3256T (gene MT-TL1), G12315A (gene MT-TL2), G13513A (gene MT-ND5) and G15059A (gene MT-CYB) by RT-PCR.
authors.affiliation: Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russian Federation; Institute for Atherosclerosis Research, Skolkovo Innovative Centre, Moscow Region, Russian Federation.
authors.forename: Konstantin Y
authors.initials: KY
authors.lastname: Mitrofanov
authors.affiliation: Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow, Russian Federation.
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Zhelankin
authors.affiliation: Institute for Atherosclerosis Research, Skolkovo Innovative Centre, Moscow Region, Russian Federation; Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow, Russian Federation.
authors.forename: Gulnara M
authors.initials: GM
authors.lastname: Shiganova
authors.affiliation: Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russian Federation; Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow, Russian Federation.
authors.forename: Margarita A
authors.initials: MA
authors.lastname: Sazonova
authors.affiliation: Institute for Atherosclerosis Research, Skolkovo Innovative Centre, Moscow Region, Russian Federation; Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, Australia; School of Medicine, University of Western Sydney, Campbelltown NSW, Australia. Electronic address: y.bobryshev@unsw.edu.au.
authors.forename: Yuri V
authors.initials: YV
authors.lastname: Bobryshev
authors.affiliation: Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow, Russian Federation.
authors.forename: Anton Y
authors.initials: AY
authors.lastname: Postnov
authors.affiliation: Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russian Federation; Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow, Russian Federation.
authors.forename: Igor A
authors.initials: IA
authors.lastname: Sobenin I А
authors.affiliation: Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russian Federation; Institute for Atherosclerosis Research, Skolkovo Innovative Centre, Moscow Region, Russian Federation; Department of Biophysics, Biological Faculty, Moscow State University, Moscow, Russian Federation.
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Orekhov
mesh_terms: D003324:Coronary Artery Disease / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D050259:Genes, Mitochondrial / Q000235:genetics*; D054629:Genome, Mitochondrial / Q000235:genetics*; D006801:Humans; D008928:Mitochondria / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D009203:Myocardial Infarction / Q000235:genetics; D012307:Risk Factors
chemical_list: D004272:DNA, Mitochondrial
keywords: Atherosclerosis; Coronary heart disease; Heteroplasmy; Infarction; Mitochondrial mutations