title: The Intestinal Microbiome and the Liver Transplant Recipient: What We Know and What We Need to Know.
abstract: The intestinal microbiome and immune system are in close symbiotic relationship in health. Gut microbiota plays a role in many chronic liver diseases and cirrhosis. However, alterations in the gut microbiome after liver transplantation and the implications for liver transplant recipients are not well understood and rely mainly on experimental animal studies. Recent advances in molecular techniques have identified that increased intestinal permeability, decreased beneficial bacteria, and increased pathogenic species may play important roles in the early posttransplant period. The associations between microbiota perturbation and postliver transplant infections and acute rejection are evolving. The link with metabolic syndrome, obesity, and cardiac disease in the general population require translation into the transplant recipient. This review focuses on our current knowledge of the known and potential interaction of the microbiome in the liver transplant recipient. Future human studies focused on microbiota changes in liver transplant patients are warranted and expected.
authors.affiliation: 1 Division of Gastroenterology and Hepatology, Medical University, Sofia, Bulgaria. 2 Division of Gastroenterology and Hepatology, Mayo Clinic Transplant Center, Rochester, MN.
authors.forename: Iliana
authors.initials: I
authors.lastname: Doycheva
authors.forename: Michael D
authors.initials: MD
authors.lastname: Leise
authors.forename: Kymberly D
authors.initials: KD
authors.lastname: Watt
mesh_terms: D000818:Animals; D001419:Bacteria / Q000145:classification / Q000276:immunology / Q000472:pathogenicity*; D018988:Bacterial Translocation; D064806:Dysbiosis; D000069196:Gastrointestinal Microbiome; D006084:Graft Rejection / Q000276:immunology / Q000382:microbiology; D054884:Host-Pathogen Interactions; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007422:Intestines / Q000276:immunology / Q000382:microbiology*; D008103:Liver Cirrhosis / Q000276:immunology / Q000382:microbiology / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents