title: Coexistence of hepatoma with mantle cell lymphoma in a hepatitis B carrier.
abstract: The coexistence of hepatocellular carcinoma (HCC) and non-Hodgkin's lymphoma (NHL) in the liver is rare. Reports show that these patients have cirrhotic livers or hepatitis virus infections before they develop HCC and NHL. We present a patient with hepatitis B virus infection who was transferred to our hospital with a newly detected liver mass; abdominal computed tomography examination showed one hypodense mass of 7 cm in diameter and multiple mesenteric and mediastinal lymph nodes. A liver tumor biopsy showed a hepatoma, and the pathologic findings from an inguinal lymph node excision showed mantle cell lymphoma. An immunohistochemical stain conﬁrmed that the atypical lymphoid cells within the HCC were positive for the CD20, CD5 and cyclin D1 antigens. Taking these ﬁndings into account, the hepatic tumor was determined to be a HCC inﬁltrated by mantle cell lymphoma.
authors.affiliation: Mu-Hsien Lee, Hao-Tsai Cheng, Hsin-Chih Huang, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
authors.forename: Mu-Hsien
authors.initials: MH
authors.lastname: Lee
authors.affiliation: Mu-Hsien Lee, Hao-Tsai Cheng, Hsin-Chih Huang, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Lin
authors.affiliation: Mu-Hsien Lee, Hao-Tsai Cheng, Hsin-Chih Huang, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
authors.forename: Hao-Tsai
authors.initials: HT
authors.lastname: Cheng
authors.affiliation: Mu-Hsien Lee, Hao-Tsai Cheng, Hsin-Chih Huang, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Chuang
authors.affiliation: Mu-Hsien Lee, Hao-Tsai Cheng, Hsin-Chih Huang, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
authors.forename: Hsin-Chih
authors.initials: HC
authors.lastname: Huang
authors.affiliation: Mu-Hsien Lee, Hao-Tsai Cheng, Hsin-Chih Huang, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
authors.forename: Hsiao-Wen
authors.initials: HW
authors.lastname: Kao
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006509:Hepatitis B / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D020522:Lymphoma, Mantle-Cell / Q000737:chemistry / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D011239:Prednisolone / Q000627:therapeutic use; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014408:Biomarkers, Tumor; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone
keywords: Hepatitis B virus; Hepatocellular carcinoma; Mantle cell lymphoma