title: Pharmacokinetics of consecutive oral moxifloxacin (400 mg/day) in patients with respiratory tract infection.
abstract: A population pharmacokinetic analysis was performed to investigate the pharmacokinetics of moxifloxacin (400 mg) following a once-daily oral administration in 28 patients with respiratory tract infection disease. The maximum plasma concentration and the area under the plasma concentration-time curve were 3.97 µg/ml and 51.74 µg·h/ml, respectively; these values were nearly equivalent to those of healthy adult men. Two adverse drug reactions (nausea, vomiting) occurred, but both reactions were mild and nonserious and the patients recovered without treatment. The pharmacokinetic profile of moxifloxacin in Japanese patients with respiratory tract infection and an underlying disease should thus be considered safe and comparable with that in healthy adult men, and adjustment of dose may do not need for age, sex, body weight, or renal function.
authors.affiliation: Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Ito
authors.affiliation: Second Department of Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan yasusi@gifu-u.ac.jp.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohno
authors.affiliation: Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Toyoshi
authors.affiliation: Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Daizo
authors.initials: D
authors.lastname: Kaito
authors.affiliation: Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Yanase
authors.initials: Y
authors.lastname: Koumei
authors.affiliation: Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Junki
authors.initials: J
authors.lastname: Endo
authors.affiliation: Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kamamiya
authors.affiliation: Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Mori
authors.affiliation: Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mori
authors.affiliation: Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Morishita
authors.affiliation: Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Funaguchi
authors.affiliation: Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Minatoguchi
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019540:Area Under Curve; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D000077266:Moxifloxacin; D012141:Respiratory Tract Infections / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D000077266:Moxifloxacin
keywords: moxifloxacin; pharmacokinetics; respiratory tract infection