title: Significance of Colonoscopic Findings in Patients After Kidney Graft.
abstract: OBJECTIVE
  We aimed to investigate the colonoscopy findings in patients after kidney transplant.
  
  
  METHODS
  We retrospectively analyzed kidney transplant patients who had colonoscopy examinations for various indications between 2011 and 2015.
  
  
  RESULTS
  Eighty-one patients (25 women and 56 men) with a mean age of 39 years (range, 18-64 y) were identified. Mean follow-up after transplant was 9 years (range, 1-29 y). The most common indications for colonoscopy were diarrhea (41%), anemia (29%), gastrointestinal bleeding (12%), abdominal pain (12%), and unexplained weight loss (6%). Either colitis or ileitis or both were diagnosed in 20 patients (25%), whereas polyps were found in 9 patients (11%). One patient presented with hematochezia, which was diagnosed as cytomegalovirus colitis. The remaining cases of colitis or ileitis were diagnosed as nonspecific inflammation. Indications for colonoscopy were not correlated with age, duration after transplant, or use of immunosuppressive drugs. A subgroup analysis for mycophenolate-induced colitis found that 88% of patients used mycophenolate, but presence of colitis or ileitis had no statistical correlation with its use. In patients with poor gastrointestinal symptoms, the only significant predictor of presence of colitis or ileitis was a high C-reactive protein value (> 5 mg/dL; P = .02).
  
  
  CONCLUSIONS
  Incidence of colitis and/or ileitis is a relatively common finding in patients after kidney transplant. Opportunistic infections, mycophenolate use, and mild degree of indeterminate colitis or ileitis disease may be the underlying condition. Cytomegalovirus infection should be screened in all recipients because it may cause serious complications or death in chronically immunocompromised patients.
authors.affiliation: From the Departments of Gastroenterology, Başkent University Faculty of Medicine, Ankara, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Ensaroğlu
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Harmancı
authors.forename: Serkan
authors.initials: S
authors.lastname: Öcal
authors.forename: Murat
authors.initials: M
authors.lastname: Korkmaz
authors.forename: Gökhan
authors.initials: G
authors.lastname: Moray
authors.forename: Handan
authors.initials: H
authors.lastname: Özdemir
authors.forename: Turan
authors.initials: T
authors.lastname: Çolak
authors.forename: Haldun
authors.initials: H
authors.lastname: Selçuk
authors.forename: Mehmet
authors.initials: M
authors.lastname: Haberal
mesh_terms: D000293:Adolescent; D000328:Adult; D003092:Colitis / Q000276:immunology / Q000473:pathology* / Q000821:virology; D003106:Colon / Q000276:immunology / Q000473:pathology* / Q000821:virology; D003113:Colonoscopy; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000473:pathology* / Q000821:virology; D005260:Female; D006801:Humans; D007079:Ileitis / Q000276:immunology / Q000473:pathology*; D007082:Ileum / Q000276:immunology / Q000473:pathology*; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007417:Intestinal Polyps / Q000276:immunology / Q000473:pathology*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000276:immunology / Q000473:pathology* / Q000821:virology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents