title: Author's Reply to Zheng et al.: A Physiologically Based Pharmacokinetic Drug-Disease Model to Predict Carvedilol Exposure in Adult and Paediatric Heart Failure Patients by Incorporating Pathophysiological Changes in Hepatic and Renal Blood Flows.
authors.affiliation: Department of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine University, 40225, Düsseldorf, Germany. fawadrasool@bzu.edu.pk.|Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 60800, Pakistan. fawadrasool@bzu.edu.pk.
authors.forename: Muhammad Fawad
authors.initials: MF
authors.lastname: Rasool
authors.affiliation: Department of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine University, 40225, Düsseldorf, Germany.
authors.forename: Feras
authors.initials: F
authors.lastname: Khalil
authors.affiliation: Department of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine University, 40225, Düsseldorf, Germany.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Läer
mesh_terms: D002227:Carbazoles / Q000493:pharmacokinetics*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male; D008954:Models, Biological; D011412:Propanolamines / Q000493:pharmacokinetics*; D012079:Renal Circulation / Q000187:drug effects*
chemical_list: D002227:Carbazoles; D011412:Propanolamines