title: Modern stem cell therapy: approach to disease.
abstract: Various types of stem cells exist, each with their own advantages and disadvantages. Considering the current available evidence, important preclinical and clinical studies regarding the therapeutic potential of stem cells, stem cell therapy might be the important strategy for tissue repair. The development of stem cell therapy for tissue repair has primarily relied on stem cells, especially mesenchymal stem cells. Multilineage differentiation into all of the described cells are considered as important candidates for a range of diseases like neurological diseases, cardiovascular diseases, gastrointestinal cancer and genetic defects, as well as for acute and chronic wounds healing and pharmaceutical treatment. We review the properties and multipotency of stem cells and their differentiation potential, once cultured under specific growth conditions, for use in cell-based therapies and functional tissue replacement.
authors.affiliation: Institute of Anatomy, Histology and Embryology, Faculty of Medicine, University of Maribor, Taborska 8, Maribor, Slovenia. mateja.zemljic@um.si.
authors.forename: Mateja
authors.initials: M
authors.lastname: Zemljic
authors.affiliation: Institute of Anatomy, Histology and Embryology, Faculty of Medicine, University of Maribor, Taborska 8, Maribor, Slovenia.
authors.forename: Bozena
authors.initials: B
authors.lastname: Pejkovic
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, University of Maribor, Taborska 8, Maribor, Slovenia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Krajnc
authors.affiliation: Institute of Anatomy, Histology and Embryology, Faculty of Medicine, University of Maribor, Taborska 8, Maribor, Slovenia.
authors.forename: Lidija
authors.initials: L
authors.lastname: Kocbek
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D057905:Stem Cell Research; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends
keywords: Cell-based therapy; Differentiation; Disease; Stem cell; Tissue replacement