title: Effect of total intravenous anaesthesia and prophylactic ramosetron on postoperative nausea and vomiting after thyroidectomy: A prospective, randomized controlled study.
abstract: OBJECTIVE
  To investigate the effect of combined prophylactic ramosetron and total intravenous anaesthesia (TIVA) on postoperative nausea and vomiting (PONV), compared with sevoflurane anaesthesia without prophylactic antiemetics, in female patients undergoing thyroidectomy.
  
  
  METHODS
  Female patients were randomized between the sevoflurane group (anaesthesia maintained with sevoflurane) or TIVA + ramosetron group (TIVAR; 0.3 mg ramosetron just before anaesthesia induction, remifentanil and propofol anaesthesia). Incidence and severity of PONV and use of rescue antiemetics were recorded during the first 24 h after surgery.
  
  
  RESULTS
  In the early postoperative period (0-6 h), the incidence of PONV, severe emesis and rescue antiemetic use were significantly lower in the TIVAR group (n = 36) than in the sevoflurane group (n = 36). In the late postoperative period (6-24 h), the incidence of severe emesis was significantly lower in the TIVAR group than in the sevoflurane group.
  
  
  CONCLUSIONS
  A combination of TIVA and prophylactic ramosetron decreases early PONV and late postoperative severe emesis compared with sevoflurane anaesthesia.
authors.affiliation: Department of Anaesthesiology and Pain Medicine, Ajou University, School of Medicine, Suwon, Republic of Korea.
authors.forename: Han Bum
authors.initials: HB
authors.lastname: Joe
authors.affiliation: Department of Anaesthesiology and Pain Medicine, Ajou University, School of Medicine, Suwon, Republic of Korea.
authors.forename: Sook Young
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Department of Anaesthesiology and Pain Medicine, Ajou University, School of Medicine, Suwon, Republic of Korea.
authors.forename: Jin-Soo
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Anaesthesiology and Pain Medicine, Ajou University, School of Medicine, Suwon, Republic of Korea.
authors.forename: Hyuk Soo
authors.initials: HS
authors.lastname: Chang
authors.affiliation: Department of Anaesthesiology and Pain Medicine, Ajou University, School of Medicine, Suwon, Republic of Korea.
authors.forename: Yunyong
authors.initials: Y
authors.lastname: Jeong
authors.affiliation: Department of Anaesthesiology and Pain Medicine, Ajou University, School of Medicine, Suwon, Republic of Korea.
authors.forename: Haewon
authors.initials: H
authors.lastname: Jeong
authors.affiliation: Department of Anaesthesiology and Pain Medicine, Ajou University, School of Medicine, Suwon, Republic of Korea anepark@hanmail.net.
authors.forename: Sung Yong
authors.initials: SY
authors.lastname: Park
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D001562:Benzimidazoles / Q000627:therapeutic use*; D003710:Demography; D005260:Female; D006801:Humans; D010880:Piperidines / Q000009:adverse effects; D020250:Postoperative Nausea and Vomiting / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control*; D015742:Propofol / Q000009:adverse effects; D011446:Prospective Studies; D000077208:Remifentanil; D013965:Thyroidectomy / Q000009:adverse effects*
chemical_list: D001562:Benzimidazoles; D010880:Piperidines; C071315:ramosetron; D000077208:Remifentanil; D015742:Propofol
keywords: Postoperative nausea and vomiting; ramosetron; thyroidectomy; total intravenous anaesthesia