title: Locally advanced basal cell carcinoma has a distinct methylation and transcriptomic profile.
authors.affiliation: Department of Dermatology, Maastricht University Medical Centre, Maastricht, The Netherlands.|GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
authors.forename: Tjinta
authors.initials: T
authors.lastname: Brinkhuizen
authors.affiliation: Department of Dermatology, Maastricht University Medical Centre, Maastricht, The Netherlands.|GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.|Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Michel
authors.initials: M
authors.lastname: van Geel
authors.affiliation: Department of Mathematical Modelling Statistics and Bioinformatics, Ghent University, Ghent, Belgium.|Institute of Medical Biology Immunos, Singapore, Singapore.
authors.forename: Simon L I J
authors.initials: SL
authors.lastname: Denil
authors.affiliation: Department of Mathematical Modelling Statistics and Bioinformatics, Ghent University, Ghent, Belgium.
authors.forename: Tim
authors.initials: T
authors.lastname: De Meyer
authors.affiliation: Department of Dermatology, Maastricht University Medical Centre, Maastricht, The Netherlands.|GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
authors.forename: Nicole W J
authors.initials: NW
authors.lastname: Kelleners-Smeets
authors.affiliation: Netherlands Cancer Institute/ Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
authors.forename: Peter J F M
authors.initials: PJ
authors.lastname: Lohuis
authors.affiliation: GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.|Department of Radiation Oncology (Maastro), Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Frank J P
authors.initials: FJ
authors.lastname: Hoebers
authors.affiliation: GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.|Department of Pathology, Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Véronique J L
authors.initials: VJ
authors.lastname: Winnepenninckx
authors.affiliation: Department of Dermatology, Maastricht University Medical Centre, Maastricht, The Netherlands.|GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.|Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands.|Institute of Medical Biology Immunos, Singapore, Singapore.|Cancer Research Division School of Medicine Dentistry and Nursing, Division of Biological Chemistry and Drug Development College of Life Sciences, University of Dundee, Dundee, UK.
authors.forename: Maurice A M
authors.initials: MA
authors.lastname: van Steensel
authors.affiliation: Department of Dermatology, Maastricht University Medical Centre, Maastricht, The Netherlands.|GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
authors.forename: Klara
authors.initials: K
authors.lastname: Mosterd
mesh_terms: D000368:Aged; D001706:Biopsy; D002280:Basal Cell Carcinoma / Q000000981:diagnostic imaging / Q000235:genetics* / Q000378:metabolism*; D019175:DNA Methylation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D009154:Mutation; D009361:Neoplasm Invasiveness; D012878:Skin Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000378:metabolism*; D014057:Tomography, X-Ray Computed; D059467:Transcriptome
keywords: MMP13; epigenetics; locally advanced basal cell carcinoma; methylome; transciptomics