title: Signaling pathways regulating Homer1a expression: implications for antidepressant therapy.
abstract: Homer1a is upregulated by several different antidepressant measures, including non-pharmacological treatments, like sleep deprivation (SD) and electroconvulsive therapy (ECT) and antidepressant drugs, such as imipramine, fluoxetine and ketamine. Homer1a induction might thus be a crucial joint mechanism for antidepressant therapy in general. However, the upstream signaling pathways that regulate or induce Homer1a expression are still not well understood. The main focus of the present review is to offer an overview of the current knowledge about the potential role of Homer1a in depression and the signaling pathways responsible for Homer1a regulation. It is suggested here that a detailed characterization of the signaling mechanisms leading to Homer1a expression might provide novel therapeutic targets for antidepressant drug development.
authors.forename: Tsvetan
authors.initials: T
authors.lastname: Serchov
authors.forename: Rolf
authors.initials: R
authors.lastname: Heumann
authors.forename: Dietrich
authors.initials: D
authors.lastname: van Calker
authors.forename: Knut
authors.initials: K
authors.lastname: Biber
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D003863:Depression / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D003866:Depressive Disorder / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D000072233:Homer Scaffolding Proteins; D006801:Humans; D043682:Receptor, Adenosine A1 / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D018631:ras Proteins / Q000378:metabolism
chemical_list: D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; D002352:Carrier Proteins; D000072233:Homer Scaffolding Proteins; D043682:Receptor, Adenosine A1; D018631:ras Proteins