title: Obesity and graft dysfunction among kidney transplant recipients: Increased risk for atherosclerosis.
abstract: Weight gain after kidney transplant is common, and may be related to graft dysfunction and high cardiovascular risk. We investigated the prevalence of obesity and evaluated the relationship between obesity and graft dysfunction in kidney transplant recipients (KTRs). All patients who received kidney transplant at the Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) between January 2005 and December 2009 were recruited. Information on demographics, clinical characteristics and post-transplant care were documented. All patients underwent transthoracic echocardiography and carotid Doppler ultrasound for the assessment of cardiac status and carotid intima-media thickness (cIMT), respectively. Inferential and modelling statistics were applied. One hundred KTRs were recruited, of which 63 were males. The mean age was 42.2 ± 12.42 years with a range of 19-70 years. The mean body mass index and waist circumference of the recipients were 26.4 ± 4.81 kg/m(2) and 90.73 ± 14.76 cm, respectively. Twenty-nine patients (29%) were obese; of these, 24 (82.8%) had moderate obesity, 4 (13.8%) had severe obesity, and 1 (3.4%) had morbid obesity. Graft dysfunction was present in 52%. Obese patients were older (P < 0.0001), had graft dysfunction (P = 0.03), higher mean arterial blood pressure (P = 0.022), total cholesterol (P = 0.019), triglycerides (P < 0.0001), left ventricular mass index (P = 0.035) and cIMT (P = 0.036). Logistic regression showed obesity to be independently associated with graft dysfunction (P = 0.033). Obesity after kidney transplantation is common and is associated with graft dysfunction and markers of atherosclerosis.
authors.affiliation: Department of Medicine, Division of Nephrology, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa ; Department of Medicine, Yariman Bakura Specialist Hospital, Gusau, Zamfara State, Nigeria.
authors.forename: M S
authors.initials: MS
authors.lastname: Aminu
authors.affiliation: Department of Medicine, Division of Nephrology, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
authors.forename: N
authors.initials: N
authors.lastname: Sagren
authors.affiliation: Department of Medicine, Division of Cardiology, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
authors.forename: P
authors.initials: P
authors.lastname: Manga
authors.affiliation: Department of Medicine, Division of Cardiology, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
authors.forename: M S
authors.initials: MS
authors.lastname: Nazir
authors.affiliation: Department of Medicine, Division of Nephrology, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
authors.forename: S
authors.initials: S
authors.lastname: Naicker
keywords: Graft dysfunction; kidney transplant recipients; obesity