title: Elevated Preoperative Serum Hs-CRP Level as a Prognostic Factor in Patients Who Underwent Resection for Hepatocellular Carcinoma.
abstract: To evaluate the effects of preoperative highly sensitive C-reactive protein (Hs-CRP) in serum on the prognostic outcomes of patients with hepatocellular carcinoma (HCC) following hepatic resection in Chinese samples.From January 2004 to December 2008, a total of 624 consecutive HCC patients who underwent hepatic resection were incorporated. Serum levels of Hs-CRP were tested at preoperation via a collection of venous blood samples. Survival analyses adopted the univariate and multivariate analyses.In our study, among the 624 screened HCC patients, 516 patients were eventually incorporated and completed follow-up. Positive correlations were found regarding preoperative serum Hs-CRP level and tumor size, Child-Pugh class, or tumor stage (all P < 0.0001). Patients with recurrence outcomes and nonsurvivors had increased Hs-CRP levels at preoperation (both P < 0.0001). When compared to the Hs-CRP-normal group, the overall survival (OS) and recurrence-free survival rates were evidently decreased in the Hs-CRP-elevated group. Further, preoperative serum Hs-CRP level might be having possible prediction effect regarding survival and recurrence of HCC patients after hepatic section in the multivariate analysis.Preoperative increased serum Hs-CRP level was an independent prognostic indicator in patients with HCC following hepatic resection in Chinese samples.
authors.affiliation: From the Department of Hepatobiliary Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, P.R. China (Y-BL, S-JK, H-SJ, ZY, LC, HY, Y-LO, J-HZ, Z-XJ) and Department of Infectious, People's Hospital of Xuyi, Jiangsu, P.R. China (JY, W-DZ, C-SL).
authors.forename: Yu-Bin
authors.initials: YB
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Ying
authors.forename: Su-Juan
authors.initials: SJ
authors.lastname: Kuang
authors.forename: Hao-Sheng
authors.initials: HS
authors.lastname: Jin
authors.forename: Zi
authors.initials: Z
authors.lastname: Yin
authors.forename: Liang
authors.initials: L
authors.lastname: Chang
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: Ying-Liang
authors.initials: YL
authors.lastname: Ou
authors.forename: Jiang-Hua
authors.initials: JH
authors.lastname: Zheng
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
authors.forename: Chuan-Sheng
authors.initials: CS
authors.lastname: Li
authors.forename: Zhi-Xiang
authors.initials: ZX
authors.lastname: Jian
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D002097:C-Reactive Protein