title: Acquired cystic disease and renal cell carcinoma in hemodialysis patients--A case report on three patients.
abstract: BACKGROUND
  Renal cell carcinoma (RCC) is derived from renal tubular epithelial cells and represents approximately 3.8% of all malignancies in adults. The incidence of renal cell carcinoma has been growing steadily and ranging from 0.6 to 14.7 for every 100,000 inhabitants. Patients with end-stage renal disease and acquired cystic kidney disease are at increased risk of developing RCC while undergoing dialysis treatment or after renal transplantation.
  
  
  METHODS
  We presented 3 patients undergoing hemodialysis, with acquired cystic kidney disease accompanied by the development of RCC. In all the patients tumor was asymptomatic and discovered through ultrasound screening in 2 patients and in 1 of the patients by post-surgery pathohistological analysis of the tissue of the kidney excised using nephrectomy. All the three patients had organ-limited disease at the time of the diagnosis and they did not require additional therapy after surgical treatment. During the follow-up after nephrectomy from 6 months to 7 years, local recurrence or metastasis of RCC were not diagnosed.
  
  
  CONCLUSIONS
  Acquired cystic kidney disease represents a predisposing factor for the development of renal cell carcinoma in dialysis patients and requires regular ultrasound examinations of the abdomen aimed at early diagnosis of malignancies. Prognosis for patients with end-stage renal disease and RCC is mostly good because these tumors are usually of indolent course.
authors.forename: Mirjana
authors.initials: M
authors.lastname: Mijušković
authors.forename: Novak
authors.initials: N
authors.lastname: Milović
authors.forename: Bozidar
authors.initials: B
authors.lastname: Kovačević
authors.forename: Dragan
authors.initials: D
authors.lastname: Jovanović
authors.forename: Dara
authors.initials: D
authors.lastname: Stefanović
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Ignjatović
authors.forename: Brankica
authors.initials: B
authors.lastname: Terzić
authors.forename: Jelena Tadić
authors.initials: JT
authors.lastname: Pilčević
authors.forename: Marijana
authors.initials: M
authors.lastname: Petrović
authors.forename: Dejan
authors.initials: D
authors.lastname: Pilčević
authors.forename: Katarina
authors.initials: K
authors.lastname: Obrencević
authors.forename: Snezana
authors.initials: S
authors.lastname: Cerović
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D006801:Humans; D033162:Incidental Findings; D052177:Kidney Diseases, Cystic / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000628:therapy*; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008875:Middle Aged; D009392:Nephrectomy; D011237:Predictive Value of Tests; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome