title: 3D surface-based registration of ultrasound and histology in prostate cancer imaging.
abstract: Several transrectal ultrasound (TRUS)-based techniques aiming at accurate localization of prostate cancer are emerging to improve diagnostics or to assist with focal therapy. However, precise validation prior to introduction into clinical practice is required. Histopathology after radical prostatectomy provides an excellent ground truth, but needs accurate registration with imaging. In this work, a 3D, surface-based, elastic registration method was developed to fuse TRUS images with histopathologic results. To maximize the applicability in clinical practice, no auxiliary sensors or dedicated hardware were used for the registration. The mean registration errors, measured in vitro and in vivo, were 1.5±0.2 and 2.1±0.5mm, respectively.
authors.affiliation: Department of Electrical Engineering, Eindhoven University of Technology, Postbus 513, 5600 MB Eindhoven, The Netherlands. Electronic address: s.g.schalk@tue.nl.
authors.forename: Stefan G
authors.initials: SG
authors.lastname: Schalk
authors.affiliation: Department of Urology, AMC University Hospital, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: Arnoud
authors.initials: A
authors.lastname: Postema
authors.affiliation: Department of Electrical Engineering, Eindhoven University of Technology, Postbus 513, 5600 MB Eindhoven, The Netherlands.
authors.forename: Tamerlan A
authors.initials: TA
authors.lastname: Saidov
authors.affiliation: Department of Electrical Engineering, Eindhoven University of Technology, Postbus 513, 5600 MB Eindhoven, The Netherlands.
authors.forename: Libertario
authors.initials: L
authors.lastname: Demi
authors.affiliation: Department of Urology, AMC University Hospital, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: Martijn
authors.initials: M
authors.lastname: Smeenge
authors.affiliation: Department of Urology, AMC University Hospital, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: Jean J M C H
authors.initials: JJ
authors.lastname: de la Rosette
authors.affiliation: Department of Electrical Engineering, Eindhoven University of Technology, Postbus 513, 5600 MB Eindhoven, The Netherlands; Department of Urology, AMC University Hospital, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: Hessel
authors.initials: H
authors.lastname: Wijkstra
authors.affiliation: Department of Electrical Engineering, Eindhoven University of Technology, Postbus 513, 5600 MB Eindhoven, The Netherlands.
authors.forename: Massimo
authors.initials: M
authors.lastname: Mischi
mesh_terms: D000465:Algorithms; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008297:Male; D011467:Prostate / Q000000981:diagnostic imaging* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D014463:Ultrasonography
keywords: 3D registration; Deformable model; Elastic registration; Histology; Prostate; Ultrasound