title: Patterns of 11C-PIB cerebral retention in mild cognitive impairment patients.
abstract: OBJECTIVE
  To evaluate the patterns of cerebral cortical distribution of (11)C-PIB in patients with mild cognitive impairment (MCI).
  
  
  METHODS
  The study included 69 patients (37 male, age range 42-79 years) with MCI, sub-classified as 53 with amnestic-MCI (A-MCI), and 16 with non-amnestic-MCI (NA-MCI). Patients underwent (11)C-PIB PET/CT scan 60min after intravenous injection of the radiotracer. A visual analysis of the images was performed by 2 experienced physicians. (11)C-PIB-positive studies were considered when gray matter uptake was equal to or greater than white matter. According to the regions involved, (11)C-PIB-positive studies were classified into A-pattern (predominant retention in frontal, anterior cingulate, lateral temporal, and basal ganglia) and B-pattern (generalized retention).
  
  
  RESULTS
  Thirty-nine of the 69 (56%) patients with MCI showed (11)C-PIB retention. Of the 53 A-MCI patients, 36 (68%) showed (11)C-PIB retention. Eleven out of 36 (30%) positive scans in A-MCI patients showed A-pattern, and 25 out of 36 (70%) patients had a B-pattern. Positive (11)C-PIB was observed in 3 out of 16 (19%) patients with NA-MCI. Regional distribution in these 3 patients showed A-pattern in 1, and B-pattern in 2 patients.
  
  
  CONCLUSIONS
  Cortical retention of (11)C-PIB was more frequent in A-MCI than in NA-MCI patients, and also B-pattern than A-pattern in the (11)C-PIB positive group. The recognition of (11)C-PIB distribution patterns allows MCI patients to be classified, and the A-pattern may offer a therapeutic window for potential future treatments.
authors.affiliation: Department of Nuclear Medicine, Molecular Imaging Group (IDIVAL), Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain. Electronic address: mnubmj@humv.es.
authors.forename: I
authors.initials: I
authors.lastname: Banzo
authors.affiliation: Department of Nuclear Medicine, Molecular Imaging Group (IDIVAL), Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
authors.forename: J F
authors.initials: JF
authors.lastname: Jiménez-Bonilla
authors.affiliation: Department of Nuclear Medicine, Molecular Imaging Group (IDIVAL), Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Martínez-Rodríguez
authors.affiliation: Department of Nuclear Medicine, Molecular Imaging Group (IDIVAL), Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Quirce
authors.affiliation: Department of Nuclear Medicine, Molecular Imaging Group (IDIVAL), Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
authors.forename: M
authors.initials: M
authors.lastname: de Arcocha-Torres
authors.affiliation: Department of Nuclear Medicine, Molecular Imaging Group (IDIVAL), Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
authors.forename: Z
authors.initials: Z
authors.lastname: Bravo-Ferrer
authors.affiliation: Department of Nuclear Medicine, Molecular Imaging Group (IDIVAL), Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Lavado-Pérez
authors.affiliation: Department of Neurology, IDIVAL, Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Sánchez-Juan
authors.affiliation: Department of Neurology, IDIVAL, Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez
authors.affiliation: Department of Nuclear Medicine, Molecular Imaging Group (IDIVAL), Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Jiménez-Alonso
authors.affiliation: Department of Nuclear Medicine, Molecular Imaging Group (IDIVAL), Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain; Department of Neurology, IDIVAL, Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
authors.forename: J
authors.initials: J
authors.lastname: López-Defilló
authors.affiliation: Department of Nuclear Medicine, Molecular Imaging Group (IDIVAL), Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Carril
mesh_terms: D000328:Adult; D000368:Aged; D000814:Aniline Compounds / Q000493:pharmacokinetics*; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism; D003072:Cognition Disorders / Q000000981:diagnostic imaging* / Q000378:metabolism; D060825:Cognitive Dysfunction; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D013844:Thiazoles / Q000493:pharmacokinetics*
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D002250:Carbon Radioisotopes; D013844:Thiazoles
keywords: (11)C-PIB; Alzheimer disease; Amyloid imaging; Demencia; Dementia; Deterioro cognitivo leve; Enfermedad de Alzheimer; Imagen amiloide; Mild cognitive impairment; Positron emission tomography; Tomografía por emisión de positrones