title: [Pathogenesis, clinical picture, and current therapy of rosacea].
abstract: Rosacea is a common chronic inflammatory disease, especially in patients with fair skin and positive family history. Typical locations are forehead, nose, cheeks and chin; the periorbital region is usually not involved. Clinical features can be very heterogeneous. Besides different subtypes (erythematotelangiectatic rosacea, papulopustular rosacea, phymatous rosacea), which often overlap, various special forms of rosacea exist. Up to 60% of patients with cutaneous rosacea suffer from ocular rosacea. In Germany, brimonidine, metronidazol, azelaic acid, and ivermectin are approved for topical therapy of rosacea; for systemic therapy, doxycycline at a subantimicrobial dose (40 mg/day) is the only approved substance. In case of resistance to this therapy, contraindications or side effects, various alternative therapies are available, however off-label.
authors.affiliation: Universitäts-Hautklinik Tübingen, 72076, Tübingen, Liebermeisterstraße 25, Deutschland.
authors.forename: L I
authors.initials: LI
authors.lastname: Gonser
authors.affiliation: BG Klinik Tübingen, Eberhard-Karls-Universität Tübingen, 72076, Tübingen, Schnarrenbergstraße 95, Deutschland.
authors.forename: C E
authors.initials: CE
authors.lastname: Gonser
authors.affiliation: Universitäts-Hautklinik Tübingen, 72076, Tübingen, Liebermeisterstraße 25, Deutschland. martin.schaller@med.uni-tuebingen.de.
authors.forename: M
authors.initials: M
authors.lastname: Schaller
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D046169:Dermoscopy / Q000379:methods*; D019317:Evidence-Based Medicine; D006801:Humans; D012393:Rosacea / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents
keywords: Demodex; Erythematotelangiectatic rosacea; Ocular rosacea; Papulopustular rosacea; Phymatous rosacea