title: A promising sword of tomorrow: Human γδ T cell strategies reconcile allo-HSCT complications.
abstract: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is potentially a curative therapeutic option for hematological malignancies. In clinical practice, transplantation associated complications greatly affected the final therapeutical outcomes. Currently, primary disease relapse, graft-versus-host disease (GVHD) and infections remain the three leading causes of a high morbidity and mortality in allo-HSCT patients. Various strategies have been investigated in the past several decades including human γδ T cell-based therapeutical regimens. In different microenvironments, human γδ T cells assume features reminiscent of classical Th1, Th2, Th17, NKT and regulatory T cells, showing diverse biological functions. The cytotoxic γδ T cells could be utilized to target relapsed malignancies, and recently regulatory γδ T cells are defined as a novel implement for GVHD management. In addition, human γδ Τ cells facilitate control of post-transplantation infections and participate in tissue regeneration and wound healing processes. These features potentiate γδ T cells a versatile therapeutical agent to target transplantation associated complications. This review focuses on insights of applicable potentials of human γδ T cells reconciling complications associated with allo-HSCT. We believe an improved understanding of pertinent γδ T cell functions would be further exploited in the design of innovative immunotherapeutic approaches in allo-HSCT, to reduce mortality and morbidity, as well as improve quality of life for patients after transplantation.
authors.affiliation: Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China. Electronic address: huyongxian2000@aliyun.com.
authors.forename: Yongxian
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Hematology, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantan Xili, Dongcheng District, Beijing 100050, China. Electronic address: cncuiqu@hotmail.com.
authors.forename: Qu
authors.initials: Q
authors.lastname: Cui
authors.affiliation: Department of Hematology, Jinhua Central Hospital, No. 351 Mingyue Road, Jinhua 312000, China. Electronic address: 68009172@qq.com.
authors.forename: Chao
authors.initials: C
authors.lastname: Luo
authors.affiliation: Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China.
authors.forename: Jimin
authors.initials: J
authors.lastname: Shi
authors.affiliation: Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China. Electronic address: hehuang.zju@gmail.com.
authors.forename: He
authors.initials: H
authors.lastname: Huang
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D006086:Graft vs Host Disease / Q000209:etiology; D019337:Hematologic Neoplasms / Q000150:complications / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D007113:Immunity, Innate; D016219:Immunotherapy, Adoptive; D007239:Infections / Q000209:etiology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics / Q000378:metabolism*; D012038:Regeneration; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism*; D014184:Transplantation, Homologous
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta
keywords: Allogeneic hematopoietic stem cell transplantation; Graft versus host disease; Infection; Leukemia; Relapse; γδ T cells