title: Health-Related Quality of Life in patients with Parkinson's disease--A systematic review based on the ICF model.
abstract: We analyzed features associated with a reduction in Health-Related Quality of Life (HRQoL) in people with idiopathic Parkinson's disease (PD). As a new approach, features were embedded in the WHO framework for measuring health and disability, the ICF model. From 609 articles screened, 114 articles were included. Features aligned with the ICF's body functions and structures domain (BFS) were investigated more often than personal features, activities of daily living, environmental factors, and participation in societal roles (95, 42, 35, 29 and 14 times, respectively). The strongest associations were found for the relationships between HRQoL and "psychosocial functioning" from the participation domain and HRQoL, and "mobility limitations" from the activities domain. For the BFS, non-motor symptoms were more closely associated with reduced HRQoL than motor symptoms. In conclusion, this systematic review (i) provides entirely new insights in the association of HRQoL with PD features, (ii) shows an imbalance between most extensively investigated and most relevant features for HRQoL, and (iii) demonstrates the usefulness of the ICF model for such an approach.
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Center of Neurology, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Diseases, DZNE, Tuebingen, Germany. Electronic address: janet.uem@uni-tuebingen.de.
authors.forename: Janet M T
authors.initials: JM
authors.lastname: van Uem
authors.affiliation: Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. Electronic address: J.Marinus@lumc.nl.
authors.forename: Johan
authors.initials: J
authors.lastname: Marinus
authors.affiliation: Clinical and Rehabilitation Sciences Research Group, Faculty of Health Sciences, The University of Sydney, PO Box 170, Lidcombe, Sydney 1825, NSW, Australia. Electronic address: Colleen.canning@sydney.edu.au.
authors.forename: Colleen
authors.initials: C
authors.lastname: Canning
authors.affiliation: McRoberts, Raamweg 43, 2596 HN The Hague, The Netherlands. Electronic address: R.vanLummel@mcroberts.nl.
authors.forename: Rob
authors.initials: R
authors.lastname: van Lummel
authors.affiliation: Department of Neurology, Philipps-University, Baldingerstrasse, D-35043 Marburg, Germany. Electronic address: Dodel@med.uni-marburg.de.
authors.forename: Richard
authors.initials: R
authors.lastname: Dodel
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Center of Neurology, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Diseases, DZNE, Tuebingen, Germany. Electronic address: inga.liepelt@uni-tuebingen.de.
authors.forename: Inga
authors.initials: I
authors.lastname: Liepelt-Scarfone
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Center of Neurology, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Diseases, DZNE, Tuebingen, Germany. Electronic address: daniela.berg@uni-tuebingen.de.
authors.forename: Daniela
authors.initials: D
authors.lastname: Berg
authors.affiliation: Physiotherapy, School of Allied Health, College of Science, Health and Engineering, La Trobe, Melbourne 3086, VIC, Australia. Electronic address: M.morris@latrobe.edu.au.
authors.forename: Meg E
authors.initials: ME
authors.lastname: Morris
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Center of Neurology, University of Tuebingen, Tuebingen, Germany; German Center for Neurodegenerative Diseases, DZNE, Tuebingen, Germany. Electronic address: walter.maetzler@uni-tuebingen.de.
authors.forename: Walter
authors.initials: W
authors.lastname: Maetzler
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D006801:Humans; D009043:Motor Activity / Q000502:physiology*; D010300:Parkinson Disease / Q000145:classification / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires; D014944:World Health Organization
keywords: Body function; International Classification of Functioning and Health; Parkinson's disease; Participation; Physical activity