title: Do Pills Have No Ills? Capturing the Impact of Direct Treatment Disutility.
abstract: Model-based economic evaluations should capture the impact on all costs and outcomes relevant to the chosen study perspective and time horizon. This editorial defines what is meant by direct treatment disutility (DTD) and describes why it could be an important harm that those designing model-based evaluations should consider. Some existing estimates of DTD identified from the current literature are summarised in terms of the methods used to elicit the values and the size of the estimated DTD. Model-based studies that include DTDs are also summarised. It was found that the values used within model-based economic evaluations (ranging from 0.00384 to 0.02) were typically smaller than the directly elicited values from the existing literature (0-0.033). Yet even with conservative estimates of DTDs, cost-effectiveness results were sensitive to their inclusion. The editorial concludes by discussing future methodological and empirical research needed to estimate more robust DTD values.
authors.affiliation: Manchester Centre for Health Economics, The University of Manchester, 4th Floor, Jean McFarlane Building, Oxford Road, Manchester, M13 9PL, UK.
authors.forename: Alexander
authors.initials: A
authors.lastname: Thompson
authors.affiliation: Population Health Sciences Division, University of Dundee, Mackenzie Building, Kirsty Semple Way, Dundee, DD2 4BF, UK.
authors.forename: Bruce
authors.initials: B
authors.lastname: Guthrie
authors.affiliation: Manchester Centre for Health Economics, The University of Manchester, 4th Floor, Jean McFarlane Building, Oxford Road, Manchester, M13 9PL, UK. katherine.payne@manchester.ac.uk.
authors.forename: Katherine
authors.initials: K
authors.lastname: Payne
mesh_terms: D003362:Cost-Benefit Analysis / Q000379:methods*; D016527:Drug Costs; D017048:Health Care Costs; D006801:Humans; D018803:Models, Economic; D011322:Primary Prevention / Q000191:economics