title: Postpartum haemorrhage in a woman with essential thrombocythemia carrying calreticulin mutation: a case report.
abstract: Coagulation disorder associated with essential thrombocythemia may exacerbate the prothrombotic state physiologically occurring during pregnancy. We report a case of a severe postpartum haemorrhage in a 35-year-old woman previously diagnosed with essential thrombocythemia and carrying the somatic calreticulin mutation. She was referred to our Thrombosis and Haemostasis Unit for pregnancy management. A treatment with low-dose aspirin was prescribed until the labour started, as the platelets count raised above 1000 × 10/l. At the time of bleeding, no residual placenta was detected at the revision of the uterine cavity.Although the postpartum is a high-risk period for thrombotic events, we have to carefully evaluate in women with essential thrombocythemia the likelihood of developing a hemorrhagic complication.
authors.affiliation: aAtherosclerosis and Thrombosis Unit bHematology Department, I.R.C.C.S. 'Casa Sollievo della Sofferenza', S. Giovanni Rotondo (Foggia), Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Villani
authors.forename: Donatella
authors.initials: D
authors.lastname: Colaizzo
authors.forename: Giovanni L
authors.initials: GL
authors.lastname: Tiscia
authors.forename: Elena
authors.initials: E
authors.lastname: Chinni
authors.forename: Carl'Antonio
authors.initials: C
authors.lastname: Bodenizza
authors.forename: Nicola
authors.initials: N
authors.lastname: Cascavilla
authors.forename: Elvira
authors.initials: E
authors.lastname: Grandone
mesh_terms: D000328:Adult; D001241:Aspirin / Q000627:therapeutic use; D037282:Calreticulin / Q000235:genetics*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D009154:Mutation; D006473:Postpartum Hemorrhage / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D011247:Pregnancy; D013920:Thrombocythemia, Essential / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000473:pathology
chemical_list: C576483:CALR protein, human; D037282:Calreticulin; D005343:Fibrinolytic Agents; D001241:Aspirin