title: Impact of Roux-en-Y gastric bypass on lipid and inflammatory profiles.
abstract: OBJECTIVE
  To evaluate the behavior of acute phase proteins and lipid profile in patients undergoing Roux-en-Y gastric bypass.
  
  
  METHODS
  We conducted a prospective study, consisting of three moments: M1 - preoperative (24 hours before surgery); M2 - 30 days after surgery; and M3 - 180 days after surgery. We carried measured height and BMI, as well as determined the concentrations of acute phase proteins (C-reactive protein (CRP), albumin and Alpha-1-acid glycoprotein) and total cholesterol, LDL-c, HDL-c and triacylglycerol.
  
  
  RESULTS
  participants comprised 25 individuals, with a mean age of 39.28 ± 8.07, 72% female. At all times of the study there was statistically significant difference as for weight loss and BMI. We found a significant decrease in CRP concentrations between the moments M1 and M3 (p = 0.041) and between M2 and M3 (p = 0.018). There was decrease in Alpha-1-GA concentrations between M1 and M2 (p = 0.023) and between M1 and M3 (p = 0.028). The albumin values increased, but did not differ between times. Total cholesterol and triacylglycerol decreased significantly ay all times. LDL-c concentrations decreased and differed between M1 and M2 (p = 0.001) and between M1 and M3 (p = 0.001). HDL-c values increased, however only differing between M1 and M2 (p = 0.050).
  
  
  CONCLUSIONS
  Roux-en-Y gastric bypass promoted a decrease in plasma concentrations of CRP and Alpha-1-acid glycoprotein, improving lipid and inflammatory profiles.
authors.affiliation: Departamento de Nutrição, Universidade Federal de Santa Catarina, Brazil.
authors.forename: Cleiton da Silva
authors.initials: Cda S
authors.lastname: Oliveira
authors.affiliation: Universidade Federal de Santa Catarina, Brazil.
authors.forename: Bruna Teles Soares
authors.initials: BT
authors.lastname: Beserra
authors.affiliation: Departamento de Nutrição, Universidade Federal de Santa Catarina, Brazil.
authors.forename: Raphael Salles Granato
authors.initials: RS
authors.lastname: Cunha
authors.affiliation: Hospital Universitário Professor Polydoro Ernani de São Thiago, Universidade Federal de Santa Catarina, Brazil.
authors.forename: Ana Gabriela Estevam
authors.initials: AG
authors.lastname: Brito
authors.affiliation: Departamento de Nutrição, Universidade Federal de Santa Catarina, Brazil.
authors.forename: Rafaella Cristina Dimbarre
authors.initials: RC
authors.lastname: de Miranda
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Santa Catarina, Brazil.
authors.forename: Lúcia Andréia Zanette Ramos
authors.initials: LA
authors.lastname: Zeni
authors.affiliation: Universidade Federal de Santa Catarina, Brazil.
authors.forename: Everson Araújo
authors.initials: EA
authors.lastname: Nunes
authors.affiliation: Universidade Federal de Santa Catarina, Brazil.
authors.forename: Erasmo Benicio Santos de Moraes
authors.initials: EB
authors.lastname: Trindade
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000601:surgery*; D011446:Prospective Studies; D015431:Weight Loss
chemical_list: D008055:Lipids; D002097:C-Reactive Protein