title: Rap2b promotes proliferation, migration, and invasion of lung cancer cells.
abstract: Rap2b, a member of the guanosine triphosphate-binding proteins, is widely up-regulated in many types of tumors. However, the functional role of Rap2b in tumorigenesis of lung cancer remains to be fully elucidated. In this study, we investigated the effect of Rap2b on the lung cancer malignant phenotype, such as cell proliferation and metastasis. We found that Rap2b could promote the abilities of lung cancer cell wound healing, migration, and invasion via increasing matrix metalloproteinase-2 enzyme activity. Furthermore, Rap2b overexpression could increase the phosphorylation level of extracellular signal-regulated protein kinases 1/2. In conclusion, our results suggested that Rap2b may be a potential therapeutic target for lung cancer.
authors.affiliation: a Department of Respiratory Medicine , The First Affiliated Hospital of Soochow University , Suzhou , China and.|b Department of Emergency , Huai'an Hospital Affiliated to Xuzhou Medical College and Huai'an Second People's Hospital , Huai'an , China.
authors.forename: Yi-Gen
authors.initials: YG
authors.lastname: Peng
authors.affiliation: b Department of Emergency , Huai'an Hospital Affiliated to Xuzhou Medical College and Huai'an Second People's Hospital , Huai'an , China.
authors.forename: Zheng-Qun
authors.initials: ZQ
authors.lastname: Zhang
authors.affiliation: a Department of Respiratory Medicine , The First Affiliated Hospital of Soochow University , Suzhou , China and.
authors.forename: Yan-Bin
authors.initials: YB
authors.lastname: Chen
authors.affiliation: a Department of Respiratory Medicine , The First Affiliated Hospital of Soochow University , Suzhou , China and.
authors.forename: Jian-An
authors.initials: JA
authors.lastname: Huang
mesh_terms: D000072283:A549 Cells; D002465:Cell Movement / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis; D009361:Neoplasm Invasiveness / Q000235:genetics; D009362:Neoplasm Metastasis; D020668:rap GTP-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D020778:Matrix Metalloproteinase 2; C065562:RAP2B protein, human; D020668:rap GTP-Binding Proteins
keywords: ERK1/2; Rap2b; lung cancer; migration