title: Brachial-ankle pulse wave velocity and ankle-brachial index are complementary tools for transcranial Doppler ultrasonography in early diagnosis of intracranial arterial stenosis/occlusion in patients with acute ischemic stroke.
abstract: The aim of this study was to explore whether brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI) are suitable to serve as complementary tools for TCD in early diagnosis of intracranial arterial stenosis/occlusion in patients with acute ischemic stroke (AIS). A total of 52 patients with AIS onset and 52 age-matched healthy controls were included in this study. All participants received TCD detection, and baPWV and ABI were measured. Computed topography (CT)/magnetic resonance imaging (MRI) was applied to confirm diagnosis. TCD data from all participants was collected and reviewed to diagnose stenosis and occlusion of the major intracranial arteries. Receiver operating characteristic (ROC) analysis and logistic regression analysis were used to assess and compare the diagnostic accuracy of the various diagnostic approaches. We found that a combination of TCD with either baPWV or ABI, or a combination of the three provided a significantly higher area under the curve (AUC) in detecting stenosis or occlusion in various intracranial arteries, excluding the anterior cerebral artery (ACA), when compared to TCD alone, thereby demonstrating that these combined approaches provide improved diagnostic accuracy. In conclusion, our findings suggest that both baPWV and ABI are suitable complementary tools for TCD in early diagnosis of intracranial arterial stenosis/occlusion in AIS patients and that these combinations may assist in facilitating the diagnostic process associated with this disease.
authors.affiliation: International Medical Center, International Medicine Division, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Zhenghao
authors.initials: Z
authors.lastname: Xuan
authors.affiliation: Department of Neurology, Medical Healthcare Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yi
authors.affiliation: Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: International Medical Center, International Medicine Division, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. Electronic address: liliqin_1999@hotmail.com.
authors.forename: Li
authors.initials: L
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index / Q000379:methods*; D001157:Arterial Occlusive Diseases / Q000175:diagnosis* / Q000209:etiology*; D001783:Blood Flow Velocity; D002545:Brain Ischemia / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis / Q000379:methods*; D012372:ROC Curve; D012189:Retrospective Studies; D020521:Stroke / Q000150:complications* / Q000209:etiology; D017585:Ultrasonography, Doppler, Transcranial
keywords: Acute ischemic stroke; Ankle-brachial index; Brachial-ankle pulse wave velocity; Diagnostic accuracy; Occlusion; Stenosis; Transcranial Doppler ultrasonography