title: Application of nitric oxide measurements in clinical conditions beyond asthma.
abstract: Fractional exhaled nitric oxide (FeNO) is a convenient, non-invasive method for the assessment of active, mainly Th2-driven, airway inflammation, which is sensitive to treatment with standard anti-inflammatory therapy. Consequently, FeNO serves as a valued tool to aid diagnosis and monitoring in several asthma phenotypes. More recently, FeNO has been evaluated in several other respiratory, infectious, and/or immunological conditions. In this short review, we provide an overview of several clinical studies and discuss the status of potential applications of NO measurements in clinical conditions beyond asthma.
authors.affiliation: Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden; Andrei.Malinovschi@medsci.uu.se.
authors.forename: Andrei
authors.initials: A
authors.lastname: Malinovschi
authors.affiliation: Department of Respiratory Medicine and Sleep, Landspitali University Hospital, Reykjavik, Iceland.
authors.forename: Dora
authors.initials: D
authors.lastname: Ludviksdottir
authors.affiliation: Department of Respiratory Medicine and Allergology, Institute for Clinical Science, Lund University, Lund, Sweden.
authors.forename: Ellen
authors.initials: E
authors.lastname: Tufvesson
authors.affiliation: Department of Medical Sciences, Allergology and Clinical Immunology, University of Torino, Torino, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Rolla
authors.affiliation: Department of Respiratory Medicine and Allergology, Institute for Clinical Science, Lund University, Lund, Sweden.
authors.forename: Leif
authors.initials: L
authors.lastname: Bjermer
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
authors.forename: Kjell
authors.initials: K
authors.lastname: Alving
authors.affiliation: Department of Respiratory Medicine and Allergology, Institute for Clinical Science, Lund University, Lund, Sweden.|Department of Clinical Pharmacy & Pharmacology, University Medical Centre Groningen, Groningen, The Netherlands.|Department of General Practice, University Medical Centre Groningen, Groningen, The Netherlands.|QPS Netherlands, Groningen, The Netherlands.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Diamant
keywords: COPD; allergic rhinitis; allograft rejections; bronchopulmonary dysplasia; cystic fibrosis; exhaled nitric oxide; hepatopulmonary syndrome; pulmonary hypertension; respiratory infections; scleroderma