title: Role of Stem Cells Transplantation in Tissue Regeneration After Acute or Chronic Acetaminophen Induced Liver Injury.
abstract: Acetaminophen-induced liver injury (APAP) is recognized as a frequent etiologic factor responsible for hepatic damage in the developed world. Management remains still elusive as treatment options are limited and their results are inconclusive. Consequently new strategies are explored at the experimental level. Mesenchymal stem cells (MSCs) present a promising modality as they can promote liver regeneration (LG) and compensate acute liver injury (ALI).
  
  
  
  Our research was focused on articles related to drug-induced liver injury, mechanisms of liver regeneration (LG) after Acute Liver Injury (ALI) and recent experimental protocols of Mesenchymal Stem Cells (MSCs) transplantation after chemical insult. All these studies are cited on Pubmed and MedLine.
  
  
  
  This review has three distinct sections. First recent developments in ALI pathogenesis are presented. The second section covers cellular pathways and histological findings relevant to liver regeneration. The final chapter analyzes MSCs transplantation protocols after ALI and interrelation between liver regeneration and hepatic differentiation of MSCs.
  
  
  
  Adipose tissue stem cells (ADSCs) and (MSCs) transplantation represents a promising modality in severe ALI management although many aspects remain to be clarified.
authors.affiliation: a Department of Propaedeutic Surgery , University of Athens, School of Medicine, General Hospital of Athens "Hippocration" , Athens , Greece.|b Experimental - Research Center , ELPEN Pharmaceuticals , Pikermi , Attica.
authors.forename: Charalampos
authors.initials: C
authors.lastname: Katselis
authors.affiliation: a Department of Propaedeutic Surgery , University of Athens, School of Medicine, General Hospital of Athens "Hippocration" , Athens , Greece.|b Experimental - Research Center , ELPEN Pharmaceuticals , Pikermi , Attica.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Apostolou
authors.affiliation: a Department of Propaedeutic Surgery , University of Athens, School of Medicine, General Hospital of Athens "Hippocration" , Athens , Greece.|b Experimental - Research Center , ELPEN Pharmaceuticals , Pikermi , Attica.
authors.forename: Themistoklis
authors.initials: T
authors.lastname: Feretis
authors.affiliation: a Department of Propaedeutic Surgery , University of Athens, School of Medicine, General Hospital of Athens "Hippocration" , Athens , Greece.|b Experimental - Research Center , ELPEN Pharmaceuticals , Pikermi , Attica.
authors.forename: Ioannis G
authors.initials: IG
authors.lastname: Papanikolaou
authors.affiliation: a Department of Propaedeutic Surgery , University of Athens, School of Medicine, General Hospital of Athens "Hippocration" , Athens , Greece.
authors.forename: George C
authors.initials: GC
authors.lastname: Zografos
authors.affiliation: a Department of Propaedeutic Surgery , University of Athens, School of Medicine, General Hospital of Athens "Hippocration" , Athens , Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Toutouzas
authors.affiliation: a Department of Propaedeutic Surgery , University of Athens, School of Medicine, General Hospital of Athens "Hippocration" , Athens , Greece.|b Experimental - Research Center , ELPEN Pharmaceuticals , Pikermi , Attica.
authors.forename: Apostolos
authors.initials: A
authors.lastname: Papalois
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000208:Acute Disease; D000273:Adipose Tissue / Q000166:cytology*; D058633:Antipyretics / Q000009:adverse effects*; D002454:Cell Differentiation / Q000502:physiology; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000209:etiology / Q000601:surgery*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008115:Liver Regeneration / Q000502:physiology*; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods / Q000639:trends; D059630:Mesenchymal Stem Cells; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D058633:Antipyretics; D016207:Cytokines; D014157:Transcription Factors; D000082:Acetaminophen; D003577:Cytochrome P-450 Enzyme System
keywords: acute liver injury (ALI); adipose tissue stem cells (ADSCs); liver regeneration (LG); mesenchymal stem cells (MSCs); paracetamol induced injury (APAP induced injury)