title: SELECTED ASPECTS OF TERAHERTZ SPECTROSCOPY IN PHARMACEUTICAL SCIENCES.
abstract: THz-TDS techniques are applied to investigate selected pharmaceutical samples. Investigations were performed on selected pharmaceutical samples with active pharmaceutical ingredients (API)--famotidine, ranitidine, fenofibrate, lovastatin, simvastatin, aspirin, ketoconazole, acyclovir (hydrated and non-hydrated), on excipients--lactose, glucose (hydrated and non-hydrated), Pluronic 127, and on mixtures of selected compounds. Pseudo-polymorphism effects are considered as well. Examples of the terahertz imaging technique are also given. APIs and excipients can be easily recognized in the terahertz band by their specific "fingerprints" as individual components and in mixtures. The hydration process as a variety of polymorphism can also be easily monitored using the THz technique. Moreover, terahertz light can be useful for the penetration of tablets, giving clear pictures of possible defects in tablet coatings.
authors.forename: Kacper
authors.initials: K
authors.lastname: Nowak
authors.forename: Edward F
authors.initials: EF
authors.lastname: Pliński
authors.forename: Bożena
authors.initials: B
authors.lastname: Karolewicz
authors.forename: Przemysław P
authors.initials: PP
authors.lastname: Jarząb
authors.forename: Stanisława
authors.initials: S
authors.lastname: Plińska
authors.forename: Bogusław
authors.initials: B
authors.lastname: Fuglewicz
authors.forename: Michał J
authors.initials: MJ
authors.lastname: Walczakowski
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Augustyn
authors.forename: Łukasz A
authors.initials: ŁA
authors.lastname: Sterczewsk
authors.forename: Michał P
authors.initials: MP
authors.lastname: Grzelczak
authors.forename: Mariusz
authors.initials: M
authors.lastname: Hruszowiec
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Beziuk
authors.forename: Martin
authors.initials: M
authors.lastname: Mikulic
authors.forename: Norbert
authors.initials: N
authors.lastname: Pałka
authors.forename: Mieczysław
authors.initials: M
authors.lastname: Szustakowskip
mesh_terms: D005079:Excipients / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013607:Tablets; D055068:Terahertz Spectroscopy / Q000379:methods*
chemical_list: D005079:Excipients; D004364:Pharmaceutical Preparations; D013607:Tablets