title: Rapid on-site evaluation during endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of hilar and mediastinal lymphadenopathy in patients with lung cancer.
abstract: The purpose of this study was to assess the usefulness of rapid on-site evaluation (ROSE) during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and the interpretation of its results. Based on the criterion of using ROSE or not, 236 patients with known or suspected lung cancer undergoing EBUS-TBNA were allocated into the ROSE group (122 patients with 252 lymph nodes) and non-ROSE group (114 patients with 260 lymph nodes). In the ROSE group, the percentages of the suspicious specimens on cytology and non-diagnostic specimens on pathology were both significantly lower than that in the non-ROSE group (8.7% vs. 14.6%, p = 0.038; and 0.9% vs. 4.4%, p = 0.018, respectively), and 13 out of 22 suspicious lesions on ROSE were confirmed with definite diagnoses on TBNA pathology. The diagnostic yield stratified by pathology was significantly higher in the ROSE group than that in the non-ROSE group (90.5% vs. 81.2%, p = 0.003). These results suggest that ROSE during EBUS-TBNA allows for a low rate of suspicious results and therefore improves the diagnostic yield stratified by pathology when sampling hilar or mediastinal lymphadenopathy in patients with lung cancer.
authors.affiliation: Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China.
authors.forename: Sujing
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Medical Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China.
authors.forename: Bobo
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Radiology, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China.
authors.forename: Wanhu
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Cytology, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China.
authors.forename: Zuowei
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Pathology, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China.
authors.forename: Jujie
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China. Electronic address: zhbaijiang@sina.com.
authors.forename: Baijiang
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China. Electronic address: sdyujinming@163.com.
authors.forename: Jinming
authors.initials: J
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001999:Bronchoscopy; D002681:China / Q000453:epidemiology; D055088:Early Detection of Cancer / Q000379:methods*; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D015995:Prevalence; D015203:Reproducibility of Results; D012189:Retrospective Studies
keywords: Diagnosis; Endobronchial ultrasound-guided transbronchial needle aspiration; Lung cancer; Lymph node; Rapid on-site evaluation