title: Emerging Agents for the Management of Nephrotic Syndrome: Progress to Date.
abstract: Nephrotic Syndrome is a rare condition associated with high morbidity in the 20-40% of children and adolescents who fail to respond to standard immunosuppressive therapies. Novel non-immunologic mechanisms of widely used immunosuppressive therapies, as well as emerging anti-inflammatory drugs, and anti-fibrotics may play a crucial role in the treatment of patients with refractory disease. This article will review some of these treatments and their various stages of investigation.
authors.affiliation: University of North Carolina Kidney Center at Chapel Hill, 7005 Burnett Womack, Chapel Hill, NC, 27599-7155, USA. kgibson@med.unc.edu.
authors.forename: Keisha L
authors.initials: KL
authors.lastname: Gibson
authors.affiliation: Chulalongkorn University, Bangkok, Thailand.
authors.forename: Panupong
authors.initials: P
authors.lastname: Hansrivijit
authors.affiliation: University of North Carolina Kidney Center at Chapel Hill, 7005 Burnett Womack, Chapel Hill, NC, 27599-7155, USA.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Ferris
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D009404:Nephrotic Syndrome / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents