title: [Endovascular stroke treatment following recent positive clinical trials].
abstract: Recently, five independent randomized controlled clinical trials demonstrated the efficacy and safety of endovascular stroke treatment in stroke patients with occlusion of proximal intracranial arteries. The five trials MR CLEAN, ESCAPE, EXTEND-IA, SWIFT-PRIME and REVASCAT randomized a total of 1287 stroke patients to either standard treatment, which in the majority of patients consisted of intravenous thrombolysis within 4.5 h of symptom onset or additional endovascular stroke treatment. In all the studies endovascular treatment resulted in a better clinical outcome with an odds ratio for a better clinical outcome 90 days after stroke ranging between 1.7 and 3.1 and an absolute increase in the proportion of patients with functionally independent outcome between 14% and 31%. The overwhelming benefit of endovascular treatment mainly results from mechanical thrombectomy using stent retriever devices and starting endovascular treatment within 6 h of symptom onset in stroke patients.
authors.affiliation: Kopf- und Neurozentrum, Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Deutschland. thomalla@uke.uni-hamburg.de.
authors.forename: G
authors.initials: G
authors.lastname: Thomalla
authors.affiliation: Diagnostikzentrum, Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Fiehler
mesh_terms: D057510:Endovascular Procedures / Q000295:instrumentation / Q000379:methods*; D019317:Evidence-Based Medicine; D006801:Humans; D061185:Mechanical Thrombolysis / Q000295:instrumentation / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D015607:Stents; D020521:Stroke / Q000175:diagnosis* / Q000601:surgery*; D016896:Treatment Outcome
keywords: Clinical trials, randomized; Endovascular techniques; Stroke, acute; Thrombectomy; Thrombolytic therapy