title: A mixed choroid plexus papilloma and ependymoma.
abstract: We report a novel case of a mixed choroid plexus papilloma (CPP) and ependymoma with cartilaginous differentiation. This kind of mixed tumor has not been previously reported in the English literature. The patient was a 5-year-old girl, who presented with a 1-week history of fever and numbness of the right lower limb. Magnetic resonance imaging of the brain with gadolinium revealed a heterogeneously enhancing mass in the occipital horn of the left lateral ventricle. Histologically, the tumor showed an intermixed CPP area and a low-grade papillary ependymoma-like area, which was studded with cartilage islands and psammoma bodies. In many foci, direct transition of CPP and ependymoma was observed, but there were no high-grade features. We report this novel case, describe the unique microscopic and immunohistochemical features, and speculate on the pathogenesis.
authors.affiliation: Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-799, Republic of Korea.
authors.forename: Yujin
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-799, Republic of Korea.
authors.forename: Seong Ik
authors.initials: SI
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, Seoul National University Children's Hospital and College of Medicine, Seoul, Republic of Korea.
authors.forename: Seung-Ki
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Department of Radiology, Seoul National University Children's Hospital and College of Medicine, Seoul, Republic of Korea.
authors.forename: In One
authors.initials: IO
authors.lastname: Kim
authors.affiliation: Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-799, Republic of Korea. shparknp@snu.ac.kr.|Neuroscience Institute, Seoul National University, College of Medicine, Seoul, Republic of Korea. shparknp@snu.ac.kr.
authors.forename: Sung-Hye
authors.initials: SH
authors.lastname: Park
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D002552:Cerebral Ventricles / Q000473:pathology; D002675:Child, Preschool; D004806:Ependymoma / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D059906:Neuroimaging; D020288:Papilloma, Choroid Plexus / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
keywords: Brain tumor; Choroid plexus papilloma; Ependymoma; Mixed glioma