title: Keratosis lichenoides chronica: Case-based review of treatment options.
abstract: Keratosis lichenoides chronica (KLC) is a rare dermatological condition characterized by keratotic papules arranged in a parallel linear or reticular pattern and facial lesions resembling seborrheic dermatitis or rosacea. The clinical, histological and therapeutic information on 71 patients with KLC retrieved through a PubMed search plus one our new case were analyzed. KLC affects patients of all ages, with a modest male predominance. Pediatric cases represent about one quarter of patients. Diagnosis is usually delayed and histologically confirmed. All patients have thick, rough and scaly papules and plaques arranged in a linear or reticular pattern, on limbs (>80%) and trunk (about 60%). Face involvement is described in two-thirds of patients. Lesions are usually asymptomatic or mildly pruritic. Other manifestations, such as palmoplantar keratoderma, mucosal involvement, ocular manifestations, nail dystrophy, are reported in 20-30% of patients. Children present more frequently alopecia. No controlled trials are available. Results from small case series or single case reports show that the best treatment options are phototherapy and systemic retinoids, alone or in combination, with nearly half of patients reaching complete remission. Systemic corticosteroids as well as antibiotics and antimalarials are not effective.
authors.affiliation: a Department of Medicine , Section of Dermatology and Venereology, University of Verona , Verona , Italy and.
authors.forename: Federica
authors.initials: F
authors.lastname: Pistoni
authors.affiliation: a Department of Medicine , Section of Dermatology and Venereology, University of Verona , Verona , Italy and.
authors.forename: Anna
authors.initials: A
authors.lastname: Peroni
authors.affiliation: b Department of Pathology and Diagnostics , Section of Pathology, University of Verona , Verona , Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Colato
authors.affiliation: a Department of Medicine , Section of Dermatology and Venereology, University of Verona , Verona , Italy and.
authors.forename: Donatella
authors.initials: D
authors.lastname: Schena
authors.affiliation: a Department of Medicine , Section of Dermatology and Venereology, University of Verona , Verona , Italy and.
authors.forename: Giampiero
authors.initials: G
authors.lastname: Girolomoni
mesh_terms: D000328:Adult; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007642:Keratosis / Q000473:pathology* / Q000628:therapy*; D017512:Lichenoid Eruptions / Q000473:pathology* / Q000628:therapy*; D008297:Male; D010789:Phototherapy / Q000379:methods; D012074:Remission Induction; D012176:Retinoids / Q000627:therapeutic use; D012867:Skin / Q000473:pathology
chemical_list: D012176:Retinoids
keywords: Keratosis lichenoides chronica; children; phototherapy; retinoids; treatment