title: Molecular Characterization of Candida africana in Genital Specimens in Shanghai, China.
abstract: Candida africana, an emerging yeast pathogen, is closely related to Candida albicans and most commonly involved in vulvovaginal candidiasis (VVC). However, its prevalence in candidal balanoposthitis is still unclear. In this study, the prevalence of C. africana in both candidal balanoposthitis and VVC in a sexually transmitted diseases (STD) clinic in Shanghai, China, was analyzed, and the molecular characterization and susceptible profiles of C. africana isolates were investigated. As results, C. africana was only isolated in 5 out of 79 (6.3%) cases of candidal balanoposthitis rather than cases with vulvovaginal candidiasis. Among them, 4 out of 5 isolates share the same genotype of DST 782 with an isolate from vaginal swab in Japan published previously. All C. africana isolates were susceptible to amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, caspofungin, and micafungin.
authors.affiliation: Department of Dermatology, Shanghai Jiading Nanxiang Hospital, Shanghai 201802, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Dermatology, Shanghai Jiading Nanxiang Hospital, Shanghai 201802, China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Yu
authors.affiliation: Department of Dermatology, Shanghai Jiading Nanxiang Hospital, Shanghai 201802, China.
authors.forename: Xiangming
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Dermatology, Shanghai Jiading Nanxiang Hospital, Shanghai 201802, China.
authors.forename: Guojiang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Medical Mycology Laboratory, Department of Dermatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Feng
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification* / Q000472:pathogenicity; D002181:Candidiasis, Vulvovaginal / Q000382:microbiology* / Q000473:pathology; D002681:China; D005260:Female; D005656:Fungal Proteins / Q000235:genetics*; D005784:Gene Amplification; D005838:Genotype; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D005656:Fungal Proteins; C118102:HWP1 protein, Candida albicans; D008562:Membrane Glycoproteins