title: The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases.
abstract: Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to bind small substances, such as steroids and lipopolysaccharides, and has been reported to have roles in the induction of apoptosis in hematopoietic cells, transport of fatty acids and iron, modulation of inflammation, and metabolic homeostasis. Recently, LCN2 has emerged as a useful biomarker and rheumatic diseases. This review provides an overview of LCN2 in inflammation, immunity, and metabolism.
authors.affiliation: a SERGAS (Servizo Galego de Saude), Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital , Santiago de Compostela , Spain .|b Departamento de Bioloxía Celular e Molecular , Facultade de Ciencias, Universidade Da Coruña (UDC) , Campus de A Coruña , Spain .
authors.forename: Vanessa
authors.initials: V
authors.lastname: Abella
authors.affiliation: a SERGAS (Servizo Galego de Saude), Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital , Santiago de Compostela , Spain .
authors.forename: Morena
authors.initials: M
authors.lastname: Scotece
authors.affiliation: a SERGAS (Servizo Galego de Saude), Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital , Santiago de Compostela , Spain .
authors.forename: Javier
authors.initials: J
authors.lastname: Conde
authors.affiliation: a SERGAS (Servizo Galego de Saude), Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital , Santiago de Compostela , Spain .
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Gómez
authors.affiliation: a SERGAS (Servizo Galego de Saude), Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital , Santiago de Compostela , Spain .
authors.forename: Ana
authors.initials: A
authors.lastname: Lois
authors.affiliation: c SERGAS, Division of Orthopaedics Surgery and Traumatology, Santiago University Clinical Hospital , Santiago de Compostela , Spain .
authors.forename: Jesús
authors.initials: J
authors.lastname: Pino
authors.affiliation: a SERGAS (Servizo Galego de Saude), Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital , Santiago de Compostela , Spain .
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Gómez-Reino
authors.affiliation: d SERGAS (Servizo Galego de Saude), Research Laboratory 7, Molecular and Cellular Cardiology Laboratory, Institute of Medical Research (IDIS), Santiago University Clinical Hospital , Santiago de Compostela , Spain .
authors.forename: Francisca
authors.initials: F
authors.lastname: Lago
authors.affiliation: e The D-BOARD European Consortium for Biomarker Discovery, Department of Veterinary Preclinical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey , Guildford , UK .|f Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, Arthritis Research UK Pain Centre, Medical Research Council and Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Nottingham, Queen's Medical Centre , Nottingham , UK , and.|g Center of Excellence in Genomic Medicine Research (CEGMR), King Fahd Medical Research Center (KFMRC), Faculty of Applied Medical Sciences, King AbdulAziz University , Jeddah , Kingdom of Saudi Arabia.
authors.forename: Ali
authors.initials: A
authors.lastname: Mobasheri
authors.affiliation: a SERGAS (Servizo Galego de Saude), Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital , Santiago de Compostela , Spain .
authors.forename: Oreste
authors.initials: O
authors.lastname: Gualillo
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism*; D000071068:Lipocalin-2; D054834:Lipocalins / Q000378:metabolism*; D008659:Metabolic Diseases / Q000175:diagnosis / Q000378:metabolism*; D011237:Predictive Value of Tests; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000378:metabolism*
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D018836:Inflammation Mediators; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins
keywords: Adipokines; adipose tissue; immunity; kidney diseases; rheumatic diseases