title: Frontline treatment of epithelial ovarian cancer.
abstract: This is a contemporaneous review of the frontline treatment of epithelial ovarian cancer (EOC), specifically on the importance of optimal surgical cytoreductive surgery, the pivotal role of platinum-based adjuvant chemotherapy (which encompasses intraperitoneal and dose-dense regimens) and the emergence of neo-adjuvant chemotherapy. Additionally, the benefit of concurrent and maintenance bevacizumab in the suboptimally debullked stage III and stage IV EOC setting is also reviewed. The article also discusses the increasing importance of prognostic and predictive molecular biomarkers in the future management of EOC.
authors.affiliation: Royal Brisbane and Women's Hospital (RBWH), Herston.|University of Queensland, St Lucia.|Greenslopes Private Hospital, Greenslopes, Queensland.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Goh
authors.affiliation: King Edward Memorial Hospital, Subiaco.|St John of God Hospital, Subiaco.|School of Women's and Infants' Health, University of Western Australia, Crawley, Western Australia.
authors.forename: G Raj
authors.initials: GR
authors.lastname: Mohan
authors.affiliation: Royal Brisbane and Women's Hospital (RBWH), Herston.
authors.forename: Rahul
authors.initials: R
authors.lastname: Ladwa
authors.affiliation: Royal Women's Hospital, Parkville, Victoria.
authors.forename: Sumitra
authors.initials: S
authors.lastname: Ananda
authors.affiliation: St John of God Hospital, Subiaco.|School of Women's and Infants' Health, University of Western Australia, Crawley, Western Australia.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Cohen
authors.affiliation: Royal North Shore Hospital, St Leonards, New South Wales, Australia.
authors.forename: Sally
authors.initials: S
authors.lastname: Baron-Hay
mesh_terms: D000077216:Carcinoma, Ovarian Epithelial; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis* / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D011379:Prognosis
keywords: epithelial ovarian cancer; molecular biomarkers; molecular targeted therapy cytoreduction surgical procedure