title: Scrolls: novel microparticulate systems for enhanced delivery to/across the skin.
abstract: We describe the scroll system as a new microparticulate structured delivery system for enhanced delivery to/across the skin. The basic components of the scroll system are non-ionic surface active of the type of alkyl polyglycol ethers and a glycol. The unique structures are preserved with addition of various ingredients such as polymers, vegetable oils, pharmaceuticals, and permeation enhancers but are dismissed when amphiphile is withdrawn. The microparticles have a unique scroll structure with multiple "wrapping." Besides enabling superior permeation of drugs into/across the skin, the drugs delivered by scroll systems were more effective in vitro and in vivo compared to controls. Model drugs presented high entrapment capacity in scroll systems. The systems are stable over time and are safe for skin application. In order to form, they require a small number of ingredients, simple preparation method, and are environment friendly. The scroll systems may be new potential tools in the dermal/transdermal pharmaceutical and cosmetic industry.
authors.affiliation: Institute of Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem, 91120, Israel.
authors.forename: Irit
authors.initials: I
authors.lastname: Allon
authors.affiliation: Institute of Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem, 91120, Israel. elka.touitou@mail.huji.ac.il.
authors.forename: Elka
authors.initials: E
authors.lastname: Touitou
mesh_terms: D000279:Administration, Cutaneous; D000700:Analgesics / Q000493:pharmacokinetics; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics; D002592:Cetomacrogol / Q000737:chemistry / Q000494:pharmacology; D020285:Cryoelectron Microscopy; D004337:Drug Carriers / Q000737:chemistry; D005260:Female; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D010539:Permeability; D012869:Skin Absorption / Q000187:drug effects; D013501:Surface-Active Agents / Q000737:chemistry / Q000494:pharmacology; D013552:Swine
chemical_list: D000700:Analgesics; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D013501:Surface-Active Agents; D002592:Cetomacrogol
keywords: Bacitracin; Betamethasone diproprionate; Ibuprofen; Scrolls; Terbinafine hydrochloride; Topical; Tramadol hydrochloride; Transdermal