title: Applications of CRISPR-Cas systems in neuroscience.
abstract: Genome-editing tools, and in particular those based on CRISPR-Cas (clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein) systems, are accelerating the pace of biological research and enabling targeted genetic interrogation in almost any organism and cell type. These tools have opened the door to the development of new model systems for studying the complexity of the nervous system, including animal models and stem cell-derived in vitro models. Precise and efficient gene editing using CRISPR-Cas systems has the potential to advance both basic and translational neuroscience research.
authors.affiliation: Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.|McGovern Institute for Brain Research, Massachusetts Institute of Technology.|Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology.|Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Matthias
authors.initials: M
authors.lastname: Heidenreich
authors.affiliation: Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.|McGovern Institute for Brain Research, Massachusetts Institute of Technology.|Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology.|Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000818:Animals; D064113:CRISPR-Cas Systems / Q000502:physiology*; D064112:Clustered Regularly Interspaced Short Palindromic Repeats / Q000502:physiology*; D005818:Genetic Engineering; D006801:Humans; D009488:Neurosciences; D057170:Translational Research, Biomedical