title: Intraoperative infusion of branched-chain amino acids in patients undergoing gastrointestinal tumor surgery.
abstract: BACKGROUND
  The purpose of this study is to investigate the effects of intraoperative infusion of branched-chain amino acids (BCAA) in patients undergoing gastrointestinal tumor surgery.
  
  
  METHODS
  Sixty-one patients with gastrointestinal tumors undergoing gastrointestinal surgery were enrolled and randomly assigned to receive an intraoperative infusion of 3-compound BCAA solution (N = 20), amino acids (AA) solution (N = 21), or normal saline (NS) (N = 20). Nasopharyngeal temperature, blood glucose (BG), plasma insulin, and blood free fatty acids (FFA) concentrations were measured at 30 min before and 10 min after induction (T 0,T 1), 30 min and 2 h after skin incision (T 2,T 3), and 1 h after tracheal extubation (T 4). Intensity of shivering and pain was accessed at 1 h after extubation.
  
  
  RESULTS
  The temperature in the BCAA and AA group was significantly higher than that in the NS group at T 4 (P = 0.014 and 0.033). The incidence of shivering in the BCAA and AA group was significantly lower than in the NS group (P = 0.027 and 0.012). BG increased in AA group at T 3 and T 4 (P = 0.001 and 0.045). The plasma insulin concentration increased in the BCAA and AA group from T 1 to T 3. The plasma FFA concentrations in the BCAA group were lower than in the AA and NS group from T 2 to T 4.
  
  
  CONCLUSIONS
  Intraoperative BCAA and AA infusion alleviated postoperative hypothermia and shivering. BCAA infusion also inhibited fat mobilization, without adversely affecting blood glucose.
  
  
  BACKGROUND
  ChiCTR-TRC-14004668.
authors.affiliation: Department of Anaesthesia, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.|Department of Anaesthesiology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Qiwei
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Anaesthesia, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.|Department of Anaesthesiology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Yanying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Anaesthesia, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.|Department of Anaesthesiology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Anaesthesia, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China. ge.shengjin@fudan.edu.cn.|Department of Anaesthesiology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. ge.shengjin@fudan.edu.cn.
authors.forename: Shengjin
authors.initials: S
authors.lastname: Ge
authors.affiliation: Department of Anaesthesia, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
authors.forename: Zhanggang
authors.initials: Z
authors.lastname: Xue
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage*; D001786:Blood Glucose; D001831:Body Temperature; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007262:Infusions, Intravenous; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000597:Amino Acids, Branched-Chain; D001786:Blood Glucose