title: Effects of flurbiprofen axetil on postoperative serum IL-2 and IL-6 levels in patients with colorectal cancer.
abstract: We explored the effects of flurbiprofen axetil on interleukin (IL)-2 and IL-6 levels in postoperative patients with colorectal cancer. A total of 120 patients (American Society of Anesthesiologists I and II) scheduled to undergo colorectal cancer surgery were randomly divided into 3 groups (N = 40 in each group): flurbiprofen axetil group (group F), morphine group (group M), and tramadol group (group T). Group M received 0.1 mg/kg morphine, group T received 1.5 mg/kg tramadol, and group F received 1.5 mg/kg flurbiprofen axetil. Patients in the 3 groups were administered treatments through intravenous injection 10 min before surgery. Serum IL-2 and IL-6 levels were detected. Postoperative adverse reactions were recorded, such as nausea, vomiting, and pruritus. The serum IL-6 level of the 3 groups increased 3 h after surgery. Compared with group M, IL-6 level was higher in group T and group F at 1 day after the surgery, and the differences between group M and the other groups were significant (P < 0.05). Moreover, the incidence of adverse reactions was significantly different among 3 groups (P < 0.05). Flurbiprofen axetil promoted the secretion of IL-2 and inhibited IL-6; additionally, flurbiprofen axetil may have a lower incidence of adverse reactions compared to other treatments.
authors.affiliation: Department of Anesthesiology II, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: W W
authors.initials: WW
authors.lastname: Jiang
authors.affiliation: Department of Anesthesiology II, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: Q H
authors.initials: QH
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology II, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: P
authors.initials: P
authors.lastname: Peng
authors.affiliation: Department of Anesthesiology II, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Liao
authors.affiliation: Department of Anesthesiology II, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: H X
authors.initials: HX
authors.lastname: Duan
authors.affiliation: Department of Anesthesiology II, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: M
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Anesthesiology II, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Second Affiliated Hospital of Xi'an Jiaotong University School of Medicine.
authors.forename: P B
authors.initials: PB
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005480:Flurbiprofen / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007376:Interleukin-2; D015850:Interleukin-6; D005480:Flurbiprofen; C504422:flurbiprofen axetil