title: Magneto acoustic tomography with short pulsed magnetic field for in-vivo imaging of magnetic iron oxide nanoparticles.
abstract: Nanoparticles are widely used as contrast and therapeutic agents. As such, imaging modalities that can accurately estimate their distribution in-vivo are actively sought. We present here our method Magneto Acoustic Tomography (MAT), which uses magnetomotive force due to a short pulsed magnetic field to induce ultrasound in the magnetic nanoparticle labeled tissue and estimates an image of the distribution of the nanoparticles in-vivo with ultrasound imaging resolution. In this study, we image the distribution of superparamagnetic iron oxide nanoparticles (IONP) using MAT method. In-vivo imaging was performed on live, nude mice with IONP injected into LNCaP tumors grown subcutaneously within the hind limb of the mice. Our experimental results indicate that the MAT method is capable of imaging the distribution of IONPs in-vivo. Therefore, MAT could become an imaging modality for high resolution reconstruction of MNP distribution in the body.
  
  
  BACKGROUND
  Many magnetic nanoparticles (MNPs) have been used as contrast agents in magnetic resonance imaging. In this study, the authors investigated the use of ultrasound to detect the presence of MNPs by magneto acoustic tomography. In-vivo experiments confirmed the imaging quality of this new approach, which hopefully would provide an alternative method for accurate tumor detection.
authors.affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Leo
authors.initials: L
authors.lastname: Mariappan
authors.affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Shao
authors.affiliation: Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Chunlan
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Shai
authors.initials: S
authors.lastname: Ashkenazi
authors.affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA; Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Bischof
authors.affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA; Institute for Engineering in Medicine, University of Minnesota, Minneapolis, MN, USA. Electronic address: binhe@umn.edu.
authors.forename: Bin
authors.initials: B
authors.lastname: He
mesh_terms: D000465:Algorithms; D000818:Animals; D045744:Cell Line, Tumor; D004867:Equipment Design; D005290:Ferric Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D060526:Magnetic Fields; D008280:Magnetics / Q000295:instrumentation / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure; D008819:Mice, Nude; D009369:Neoplasms / Q000000981:diagnostic imaging*; D014054:Tomography / Q000295:instrumentation / Q000379:methods*; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods*
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide
keywords: In-vivo; Magnetic nano particle; Magneto acoustic tomography; Magneto motive force; Ultrasound