title: The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery.
abstract: In a perfect sequence of events, nanoparticles (NPs) are injected into the bloodstream where they circulate until they reach the target tissue. The ligand on the NP surface recognizes its specific receptor expressed on the target tissue and the drug is released in a controlled manner. However, once injected in a physiological environment, NPs interact with biological components and are surrounded by a protein corona (PC). This can trigger an immune response and affect NP toxicity and targeting capabilities. In this review, we provide a survey of recent findings on the NP-PC interactions and discuss how the PC can be used to modulate both cytotoxicity and the immune response as well as to improve the efficacy of targeted delivery of nanocarriers.
authors.affiliation: Department of Regenerative Medicine, Houston Methodist Research Institute, 6670 Bertner Avenue, 77030 Houston, TX, USA.|Fondazione SDN, Via Gianturco 113, 80143 Naples, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Corbo
authors.affiliation: Department of Regenerative Medicine, Houston Methodist Research Institute, 6670 Bertner Avenue, 77030 Houston, TX, USA.
authors.forename: Roberto
authors.initials: R
authors.lastname: Molinaro
authors.affiliation: Department of Regenerative Medicine, Houston Methodist Research Institute, 6670 Bertner Avenue, 77030 Houston, TX, USA.|Fondazione SDN, Via Gianturco 113, 80143 Naples, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Parodi
authors.affiliation: Department of Regenerative Medicine, Houston Methodist Research Institute, 6670 Bertner Avenue, 77030 Houston, TX, USA.
authors.forename: Naama E
authors.initials: NE
authors.lastname: Toledano Furman
authors.affiliation: CEINGE, Advanced Biotechnology s.c.a.r.l., Via G. Salvatore 486, 80145 Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Salvatore
authors.affiliation: Department of Regenerative Medicine, Houston Methodist Research Institute, 6670 Bertner Avenue, 77030 Houston, TX, USA.
authors.forename: Ennio
authors.initials: E
authors.lastname: Tasciotti
mesh_terms: D000818:Animals; D003167:Complement Activation; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage / Q000633:toxicity*
keywords: immune response; nanomedicine; nanoparticles; nano–bio interface; protein corona; targeting; toxicity