title: Non-coding RNA in Ovarian Development and Disease.
abstract: The ovary's primary function is to produce the mature female gamete, the oocyte that, following fertilization, can develop into an embryo, implant within the uterus and ultimately allow the mother's genetic material to be passed along to subsequent generations. In addition to supporting the generation of the oocyte, the ovary and specific ephemeral tissues within it, follicles and corpora lutea, produce steroids that regulate all aspects of the reproductive system, including the hypothalamic/pituitary axis, the reproductive tract (uterus, oviduct, cervix), secondary sex characteristics all of which are also essential for pregnancy and subsequent nurturing of the offspring. To accomplish these critical roles, ovarian development and function are tightly regulated by a number of exogenous (hypothalamic/pituitary) and endogenous (intraovarian) hormones. Within ovarian cells, intricate signalling cascades and transcriptional and post-transcriptional gene regulatory networks respond to these hormonal influences to provide the exquisite control over all of the temporal and spatial events that must be synchronized to allow this organ to successfully complete its function. This book chapter will focus specifically on the role of non-coding RNAs, their identification and described functional roles within the ovary with respect to normal function and their possible involvement in diseases, which involve the ovary.
authors.affiliation: Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
authors.forename: J Browning
authors.initials: JB
authors.lastname: Fitzgerald
authors.affiliation: Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
authors.forename: Jitu
authors.initials: J
authors.lastname: George
authors.affiliation: Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA. lchristenson@kumc.edu.
authors.forename: Lane K
authors.initials: LK
authors.lastname: Christenson
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000473:pathology; D010049:Ovarian Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D010053:Ovary / Q000254:growth & development* / Q000473:pathology; D011247:Pregnancy; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D022661:RNA, Untranslated
keywords: Endo-siRNA; Folliculogenesis; Long non-coding RNA; MicroRNA; Ovarian cancer; Premature ovarian failure