title: Association Between Serum Cystatin C and High Blood Pressure (HBP): A Cross-Sectional Study of an Elder Chinese Type 2 Diabetic Population.
abstract: BACKGROUND
  The aim of this study was to investigate the relationship between serum CysC levels and high blood pressure (HBP) and to explore its diagnostic value for HBP in elder type 2 diabetic (T2D) population.
  
  
  METHODS
  A total of 369 elder T2D patients (age > 60) were included in this cross-sectional study. Their clinical and biochemical characteristics were detected. Patients were divided into two groups: with HBP and without. The risk factors of HBP were explored by binary logistic regression analysis.
  
  
  RESULTS
  The serum concentrations of CysC were 1.08 ± 0.42 and 0.90 ± 0.21 mg/L in patients with and without HBP, respectively. Binary logistic regression analysis showed that the significant risk factors were CysC (p = 0.000, OR = 16.977), systolic blood pressure (p = 0.000, OR = 1.087), and diabetes duration (p = 0.000, OR = 1.289). The prevalence of HBP increased with CysC (p < 0.05), and the prevalence of HBP in patients with CysC ≥ 1.2 mg/L was much higher than the other three quartile groups. The risk of HBP dramatically increased in patients with cystatin C ≥ 1.2 mg/L (OR = 1.601, 95% confidence interval 1.239 - 2.069, p = 0.000). After adjusting for gender, age, and diabetes duration, its OR still remained 1.633 (95% confidence interval 1.181 - 2.257, p = 0.003).
  
  
  CONCLUSIONS
  There was a strong and independent association between CysC and HBP in elder diabetic population, and cystatin C ≥ 1.2 mg/L indicated a great increased risk of HBP.
authors.forename: Pan
authors.initials: P
authors.lastname: Gao
authors.forename: Kun
authors.initials: K
authors.lastname: Zhao
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Wang
authors.forename: Hang
authors.initials: H
authors.lastname: Xiao
authors.forename: Liang-Yi
authors.initials: LY
authors.lastname: Si
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Li
mesh_terms: D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D002681:China; D003430:Cross-Sectional Studies; D055316:Cystatin C / Q000097:blood*; D048909:Diabetes Complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D055316:Cystatin C