title: MCO Membranes: Enhanced Selectivity in High-Flux Class.
abstract: Novel MCO high-flux membranes for hemodialysis have been developed with optimized permeability, allowing for filtration close to that of the natural kidney. A comprehensive in vitro characterization of the membrane properties by dextran filtration is presented. The sieving profile of pristine membranes, as well as that of membranes exposed to blood for 40 minutes, are described. The effective pore size (Stokes-Einstein radius) was estimated from filtration experiments before and after blood exposure, and results were compared to hydrodynamic radii of middle and large uremic toxins and essential proteins. The results indicate that the tailored pore sizes of the MCO membranes promote removal of large toxins while ensuring the retention of albumin.
authors.affiliation: Gambro Dialysatoren GmbH, Research &Development, Holger-Crafoord-Str. 26, 72379 Hechingen, Germany.
authors.forename: Adriana
authors.initials: A
authors.lastname: Boschetti-de-Fierro
authors.affiliation: Gambro Dialysatoren GmbH, Research &Development, Holger-Crafoord-Str. 26, 72379 Hechingen, Germany.
authors.forename: Manuel
authors.initials: M
authors.lastname: Voigt
authors.affiliation: Gambro Dialysatoren GmbH, Research &Development, Holger-Crafoord-Str. 26, 72379 Hechingen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Storr
authors.affiliation: Gambro Dialysatoren GmbH, Research &Development, Holger-Crafoord-Str. 26, 72379 Hechingen, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Krause
mesh_terms: D006801:Humans; D008567:Membranes, Artificial; D008956:Models, Chemical; D006435:Renal Dialysis / Q000295:instrumentation* / Q000379:methods*
chemical_list: D008567:Membranes, Artificial