title: [Intraosseous sampling can be valuable in emergency situations].
abstract: Intraosseous administration of fluids and drugs is valuable when vascular access is difficult to achieve. Intraosseous needles are useful tools in such cases. Sampling of aspirates through such needles have raised concern regarding the possibility that aspirated bone marrow particles could damage analysis equipment. We recommend that point-of-care equipment should be used as far as possible when intraosseous aspirates are analyzed. This is especially relevant when whole blood (i.e. blood gases) is analyzed.When centrifuged, possibly occurring bone marrow particles are deposited in the pellet, whereas the supernatant essentially corresponds to plasma. We have successfully analyzed creatinine, morphine and troponin in such samples. Leucocytes and platelets, which are formed in the bone marrow, may cause falsely elevated values when intraosseous aspirates are analyzed. The risk of hemolysis, and its potential effect on certain analyses, should be considered.
authors.affiliation: Anesth & Crit Care - Dept Surg Sci Uppsala, Sweden Anesth & Crit Care - Dept Surg Sci Uppsala, Sweden.
authors.forename: Mats
authors.initials: M
authors.lastname: Eriksson
authors.affiliation: Anesth & Crit Care - Dept Surg Sci Uppsala, Sweden Anesth & Crit Care - Dept Surg Sci Uppsala, Sweden.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Strandberg
authors.affiliation: Anesth & Crit Care - Dept Surg Sci Uppsala, Sweden Anesth & Crit Care - Dept Surg Sci Uppsala, Sweden.
authors.forename: Miklós
authors.initials: M
authors.lastname: Lipcsey
authors.affiliation: Clinical Chemistry - Dept Med Sci Uppsala, Sweden Clinical Chemistry - Dept Med Sci Uppsala, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Larsson
mesh_terms: D001774:Blood Chemical Analysis / Q000379:methods*; D001800:Blood Specimen Collection / Q000379:methods*; D001853:Bone Marrow / Q000098:blood supply*; D016638:Critical Illness; D006403:Hematologic Tests / Q000379:methods; D006801:Humans; D019095:Point-of-Care Systems