title: Anchoring Transitions of Liquid Crystals for Optical Amplification of Phospholipid Oxidation Inhibition by Ascorbic Acid.
abstract: There is considerable evidence that the antioxidant property of ascorbic acid (AH) is effective for reducing oxidative stress of phospholipids. Herein, a liquid crystals (LCs)-based method was developed for the optical amplification of resistance to phospholipid oxidation by AH. Phospholipid peroxidation initiated by free radicals was monitored from a homeotropic-to-planar anchoring transition of LCs via polarized optical microscopy. Alternatively, consistent homeotropic anchoring of LCs was observed when the oxidation caused by free radicals was blocked by AH.
authors.affiliation: Department of Chemistry, Gachon University.
authors.forename: Minmin
authors.initials: M
authors.lastname: Zhang
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Jang
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D001205:Ascorbic Acid / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D007501:Iron / Q000737:chemistry; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects; D050866:Liquid Crystals / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008859:Microscopy, Polarization / Q000379:methods*; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000975:Antioxidants; C045076:Fenton's reagent; D010743:Phospholipids; D006861:Hydrogen Peroxide; D007501:Iron; D001205:Ascorbic Acid