title: Evaluation of treatment outcomes and clinical indications for antibiotic prophylaxis in patients undergoing implantation procedures.
abstract: OBJECTIVE
  The use of antibiotic therapy during implantation to reduce the risk of an early implant failure is widely discussed among clinicists. However, half an hour after the procedure a quarter of patients show bacteremia which could decrease the efficacy of the surgery. Implant failure is associated with destruction of bone tissue within the alveolar process and may lead to an alternative but compromised treatment plan. The aim of the study was to evaluate the influence of perioperative antibiotic protection on success of implantation.
  
  
  METHODS
  The retrospective study involved 1915 patients (females: 57.3%, males: 42.7%) with no systemic or local diseases, who required antibiotic therapy during surgical procedures. Group 1 comprised 203 patients with diagnosed vertical or horizontal bone atrophy within the alveolar ridge requiring reconstruction procedure before implantation. Group 2 included 1712 patients who did not need any surgical procedures before implantation. All the subjects took three types of antibiotics twice a day for 7 days. The data were statistically analyzed.
  
  
  RESULTS
  A total number of 3309 implants were placed. Implantation efficacy in group 1 amounted to 98.53% and in group 2 it was 99.24%. Complications occurred most commonly after administration of cephalosporin which proved to be statistically significant for the patients who underwent augmentation with a bone block before the implant procedure (p 0.0209).
  
  
  CONCLUSIONS
  Perioperative use of antibiotic therapy beneficially influences tissue healing, provides safety and success of the surgical procedure, as well as translates into high efficacy of implantation (99.52%).
authors.affiliation: Department of Orthodontics, Warsaw Medical University, Warsaw, Poland. Electronic address: mkrasny@op.pl.
authors.forename: Marta
authors.initials: M
authors.lastname: Krasny
authors.affiliation: Medicare Dental Practice, Warsaw, Poland. Electronic address: kornel.krasny@op.pl.
authors.forename: Kornel
authors.initials: K
authors.lastname: Krasny
authors.affiliation: Department of Orthodontics, Warsaw Medical University, Warsaw, Poland. Electronic address: malgorzatazadurska@wp.pl.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Zadurska
authors.affiliation: Department of General and Transplantation Surgery, Transplantation Institute, Warsaw Medical University, Warsaw, Poland. Electronic address: piotrfiedor@wp.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Fiedor
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D017266:Dental Prosthesis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibiotic prophylaxis; Dental implant; Early implant failure; Implants