title: Burkholderia cepacia complex: clinical course in cystic fibrosis patients.
abstract: BACKGROUND
  Pulmonary deterioration after B.cepacia complex (BCC) colonization has a heterogeneous pattern. The aim was to investigate the clinical outcome of BCC colonization in CF patients chronically colonized with P. aeruginosa.
  
  
  METHODS
  CF patients chronically colonized with P. aeruginosa were divided into three groups: intermittent (I), chronic (II) and no colonization (III) with BCC. Body mass index (BMI) percentile and spirometric parameters were analyzed at three different times in each group.
  
  
  RESULTS
  Fifty-six patients chronically colonized with P. aeruginosa were included. Of these, 27 also had evidence of BCC colonization (13 intermittent and 14 chronic). BMI percentile was significantly lower among patients chronically colonized by both P. aeruginosa and BCC. Mean values of FEV1 and FVC % were also significantly lower in these patients, both at the time of chronic BCC colonization and 24 months forward.
  
  
  CONCLUSIONS
  Chronic BCC colonization is associated with significant loss of lung function. Lower BMI might be a risk factor for chronic BCC colonization, preceding these events.
authors.affiliation: Department of Pediatric Pulmonology, Instituto Fernandes Figueira (Fundação Oswaldo Cruz, Ministério da Saúde), Av. Rui Barbosa, 716, 2nd floor, Flamengo, Zip Code: 22250-020, Rio de Janeiro, RJ, Brazil. taniafolescu@hotmail.com.
authors.forename: Tania Wrobel
authors.initials: TW
authors.lastname: Folescu
authors.affiliation: Department of Pulmonology, Universidade do Estado do Rio de Janeiro/UERJ, Rio de Janeiro, RJ, Brazil. ccosta.uerj@gmail.com.
authors.forename: Claudia Henrique
authors.initials: CH
authors.lastname: da Costa
authors.affiliation: Department of Pediatric Pulmonology, Instituto Fernandes Figueira (Fundação Oswaldo Cruz, Ministério da Saúde), Av. Rui Barbosa, 716, 2nd floor, Flamengo, Zip Code: 22250-020, Rio de Janeiro, RJ, Brazil. renatawfc@gmail.com.
authors.forename: Renata Wrobel Folescu
authors.initials: RW
authors.lastname: Cohen
authors.affiliation: Department of Microbiology, Hospital Central da Aeronáutica, Rio de Janeiro, RJ, Brazil. orlandoccnetto@yahoo.com.br.
authors.forename: Orlando Carlos
authors.initials: OC
authors.lastname: da Conceição Neto
authors.affiliation: Department of Biochemistry, Universidade do Estado do Rio de Janeiro/UERJ, Rio de Janeiro, RJ, Brazil. albano@uerj.br.
authors.forename: Rodolpho Mattos
authors.initials: RM
authors.lastname: Albano
authors.affiliation: Department of Microbiology, Universidade do Estado do Rio de Janeiro/UERJ, Rio de Janeiro, RJ, Brazil. elizabethamarques@gmail.com.
authors.forename: Elizabeth Andrade
authors.initials: EA
authors.lastname: Marques
mesh_terms: D015992:Body Mass Index; D019121:Burkholderia Infections / Q000503:physiopathology*; D042602:Burkholderia cepacia complex; D002353:Carrier State / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D060085:Coinfection; D003550:Cystic Fibrosis / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011552:Pseudomonas Infections / Q000503:physiopathology; D011550:Pseudomonas aeruginosa; D012189:Retrospective Studies; D013147:Spirometry; D014797:Vital Capacity