title: Pneumococcal conjugate vaccine use in adults.
abstract: Streptococcus pneumoniae is a leading cause of illness and death in adults. A polysaccharide vaccine has been available for over 30 years, but despite significant use, the public health impact of this vaccine has been limited. The 13-valent pneumococcal conjugate vaccine (PCV13) has been licensed by the US Food and Drug Administration and other international regulatory authorities with the assumption that induction of a T cell-dependent immune response and noninferior immunogenicity to vaccine antigens when compared with the polysaccharide vaccine would be important to satisfy a significant unmet medical need. PCV13 efficacy against vaccine-type pneumococcal community-acquired pneumonia was confirmed in a large randomized controlled trial in older adults and its use is now increasingly recommended globally.
authors.affiliation: a Pfizer Inc , Collegeville , PA , USA.
authors.forename: Raul E
authors.initials: RE
authors.lastname: Isturiz
authors.affiliation: b Pfizer Pharma, GmbH , Berlin , Germany.
authors.forename: Beate
authors.initials: B
authors.lastname: Schmoele-Thoma
authors.affiliation: c Pfizer Vaccine Clinical Research , Pearl River , NY , USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Scott
authors.affiliation: a Pfizer Inc , Collegeville , PA , USA.
authors.forename: Luis
authors.initials: L
authors.lastname: Jodar
authors.affiliation: d Pfizer Vaccine Clinical Research , Maidenhead , UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Webber
authors.affiliation: a Pfizer Inc , Collegeville , PA , USA.
authors.forename: Heather L
authors.initials: HL
authors.lastname: Sings
authors.affiliation: e Paradiso Biologics Consulting, LLC , Radnor , PA , USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Paradiso
mesh_terms: D000328:Adult; D017714:Community-Acquired Infections / Q000453:epidemiology* / Q000517:prevention & control*; D006801:Humans; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D011018:Pneumonia, Pneumococcal / Q000453:epidemiology* / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D014481:United States / Q000453:epidemiology; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology
chemical_list: C538862:13-valent pneumococcal vaccine; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate
keywords: Community-acquired pneumonia; Streptococcus pneumoniae; adults; invasive pneumococcal disease; pneumococcal conjugate vaccine