title: Boron nitride nanotubes included thermally cross-linked gelatin-glucose scaffolds show improved properties.
abstract: Boron nitride nanotubes (BNNTs) are increasingly investigated for their medical and biomedical applications due to their unique properties such as resistance to oxidation, thermal and electrical insulation, and biocompatibility. BNNTs can be used to enhance mechanical strength of biomedical structures such as scaffolds in tissue engineering applications. In this study, we report the use of BNNTs and hydroxylated BNNTs (BNNT-OH) to improve the properties of gelatin-glucose scaffolds prepared with electrospinning technique. Human dermal fibroblast (HDF) cells are used for the toxicity assessment and cell seeding studies. It is found that the addition of BNNTs into the scaffold does not influence cell viability, decreases the scaffold degradation rate, and improves cell attachment and proliferation compared to only-gelatin scaffold.
authors.affiliation: Department of Genetics and Bioengineering, Yeditepe University, Atasehir, Istanbul 34755, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Şen
authors.affiliation: Department of Genetics and Bioengineering, Yeditepe University, Atasehir, Istanbul 34755, Turkey. Electronic address: mculha@yeditepe.edu.tr.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Culha
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001896:Boron Compounds / Q000737:chemistry*; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D055664:Electrochemical Techniques / Q000379:methods; D005780:Gelatin / Q000737:chemistry* / Q000378:metabolism; D005947:Glucose / Q000737:chemistry* / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D055595:Mechanical Phenomena; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D001896:Boron Compounds; C017282:boron nitride; D005780:Gelatin; D005947:Glucose
keywords: BNNT-OH; Boron nitride nanotubes; Cell proliferation; Gelatin; Mechanical strength; Scaffold