title: C1q and tumor necrosis factor-related protein 3 is present in human cord blood and is associated with fetal growth.
abstract: BACKGROUND
  To determine the presence of C1q and tumor necrosis factor-related protein 3 (CTRP3) in cord blood and its relationship with fetal growth among Chinese newborns.
  
  
  METHODS
  This pilot study recruited 126 infants (small for gestational age [SGA], n=34; appropriate for gestational age [AGA], n=60; large for gestational age [LGA], n=32); cord blood CTRP3 levels were measured, and fetal growth parameters were collected.
  
  
  RESULTS
  Median (25-75th percentile) CTRP3 levels in the SGA, AGA, and LGA groups were 297.2 (236.4-360.2), 297.5 (261.0-369.9), and 368.6 (298.5-507.1) ng/ml, respectively (P=0.01). LGA infants had higher CTRP3 levels than AGA infants (multiple linear regression analysis; P=0.01). The CTRP3 levels were positively correlated with birth weight (r=0.25, P<0.01), Ponderal index (r=0.28, P<0.01), and placental weight (r=0.20, P=0.03) in the total study population. In the subgroup analysis, CTRP3 levels were negatively correlated with birth length z scores (r=-0.39, P=0.03) and were positively correlated with the Ponderal index (r=0.43, P=0.02) only in the SGA group; no other significant correlations were observed. The CTRP3 levels were similar between the sexes (P=NS).
  
  
  CONCLUSIONS
  CTRP3 is present in cord blood and might be involved in fetal growth.
authors.affiliation: Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
authors.forename: Nian-Nian
authors.initials: NN
authors.lastname: Chen
authors.affiliation: Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: He
authors.affiliation: Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Li
authors.affiliation: Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
authors.forename: Ya-Shu
authors.initials: YS
authors.lastname: Kuang
authors.affiliation: Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
authors.forename: Ming-Yang
authors.initials: MY
authors.lastname: Yuan
authors.affiliation: Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
authors.forename: Xiao-Dan
authors.initials: XD
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
authors.forename: Hui-Zhu
authors.initials: HZ
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
authors.forename: Shun-Ping
authors.initials: SP
authors.lastname: Hu
authors.affiliation: Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Xia
authors.affiliation: Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. Electronic address: qxiu0161@163.com.
authors.forename: Xiu
authors.initials: X
authors.lastname: Qiu
mesh_terms: D000328:Adult; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D047109:Fetal Development; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010865:Pilot Projects; D011247:Pregnancy; D048069:Tumor Necrosis Factors / Q000097:blood*
chemical_list: C506069:C1QTNF3 protein, human; D048069:Tumor Necrosis Factors
keywords: CTRP3; Cord blood; Large for gestational age; Small for gestational age