title: [Intratympanic methylprednisolone hemisuccinate injection in treating the refractory noise induced deafness].
abstract: OBJECTIVE
  To analyze the efficacy of Methylprednisolone hemisuccinate intratympanic injection for refractory noise induced deafness.
  
  
  METHODS
  One hundred and twenty cases (215 ears) of noise induced deafness were treated with either hormone group (107 ears) or with non hormone group (108 ears). Following prior interventions, 145 ears went on to receive intratympanic Methylprednisolone hemisuccinate injection twice a week.
  
  
  RESULTS
  After Intratympanic therapy, the total effective rate was 46.2%. 32 of 71 ears (45.1%) demonstrated hearing improvement in hormone group and 35 of 74 ears (47.3%) in non hormone group. The difference was statistically insignificant (P = 0.788).
  
  
  CONCLUSIONS
  Intratympanic therapy appears to provide additional treatment benefits for patients with refractory noise induced deafness who have been treated with prior interventions. The outcome is not affected by pretreatment with hormone.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Tianjin Teda Hospital, Tianjin 300457, China.
authors.forename: Yuanqing
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Tianjin Teda Hospital, Tianjin 300457, China; E-mail: tdent@126.com.
authors.forename: Jialiang
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Tianjin Teda Hospital, Tianjin 300457, China.
authors.forename: Huiling
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Tianjin Teda Hospital, Tianjin 300457, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Bao
mesh_terms: D005938:Glucocorticoids / Q000627:therapeutic use*; D006317:Hearing Loss, Noise-Induced / Q000188:drug therapy*; D006320:Hearing Tests; D006801:Humans; D000069555:Injection, Intratympanic; D008776:Methylprednisolone Hemisuccinate / Q000627:therapeutic use*; D009622:Noise; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D008776:Methylprednisolone Hemisuccinate