title: Nocturia Potentially Influences Maintenance of Sexual Function in Elderly Men with Benign Prostatic Hyperplasia.
abstract: OBJECTIVE
  This study examined the relationship between bothersome symptoms of nocturia and erectile function.
  
  
  METHODS
  Subjects comprised patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH). Patients were prospectively followed on treatment with the alpha-1 blocker naftopidil for 8 weeks. Patient backgrounds and efficacy of naftopidil associated with LUTS and sexual activity were evaluated.
  
  
  RESULTS
  The percentage of patients who identified nocturia as the most bothersome symptom was 30.2% (n = 135), representing the highest percentage among International Prostate Symptom Score (IPSS) items. The number of patients with nocturia as the most bothersome symptom plateaued at an IPSS for nocturia of two or three points. In contrast, the number of patients with slow stream as the most bothersome symptom increased with symptom severity according to IPSS for slow stream. Logistic regression analysis on association between nocturia and erectile function confirmed that the odds ratio was 1.41 (P < 0.05). Naftopidil showed excellent efficacy related to male LUTS, but International Index of Erectile Function 5 (IIEF5) total score was almost unchanged. Among patients with nocturia improved by naftopidil, IIEF5 total score was significantly changed in the group with IPSS nocturia score ≤1 as compared to the group with IPSS nocturia score ≥2 per night (P = 0.038).
  
  
  CONCLUSIONS
  Nocturia the most bothersome symptom correlated with aging. Nocturia could associate erectile dysfunction, and keeping the frequency of nocturia at ≤1 episode might be meaningful for maintaining quality of life in elderly men.
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishizuka
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Hideyasu
authors.initials: H
authors.lastname: Matsuyama
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Sakai
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Matsubara
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Nagaoka
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Takeda
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Ozono
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Shiroki
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Shuin
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Hara
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Kakizaki
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Taiji
authors.initials: T
authors.lastname: Tsukamoto
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Yamanishi
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokoyama
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kakehi
authors.affiliation: Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Nishizawa
keywords: International Index of Erectile Function 5; benign prostatic hyperplasia; erectile dysfunction; male lower urinary tract symptoms; nocturia