title: Totally asymmetric simple exclusion process simulations of molecular motor transport on random networks with asymmetric exit rates.
abstract: Using the totally asymmetric simple-exclusion-process and mean-field transport theory, we investigate the transport in closed random networks with simple crossing topology-two incoming, two outgoing segments, as a model for molecular motor motion along biopolymer networks. Inspired by in vitro observation of molecular motor motion, we model the motor behavior at the intersections by introducing different exit rates for the two outgoing segments. Our simulations of this simple network reveal surprisingly rich behavior of the transport current with respect to the global density and exit rate ratio. For asymmetric exit rates, we find a broad current plateau at intermediate motor densities resulting from the competition of two subnetwork populations. This current plateau leads to stabilization of transport properties within such networks.
authors.affiliation: Institute of Physics, University of Amsterdam, P.O. Box 94485, 1090 GL Amsterdam, The Netherlands.
authors.forename: D V
authors.initials: DV
authors.lastname: Denisov
authors.affiliation: Institute of Physics, University of Amsterdam, P.O. Box 94485, 1090 GL Amsterdam, The Netherlands.
authors.forename: D M
authors.initials: DM
authors.lastname: Miedema
authors.affiliation: Institute of Physics, University of Amsterdam, P.O. Box 94485, 1090 GL Amsterdam, The Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: Nienhuis
authors.affiliation: Institute of Physics, University of Amsterdam, P.O. Box 94485, 1090 GL Amsterdam, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Schall