title: Long noncoding RNAs in hepatocellular carcinoma: Novel insights into their mechanism.
abstract: Hepatocellular carcinoma (HCC) is the predominant subject of liver malignancies which arouse global concern. Advanced studies have found that long noncoding RNAs (lncRNAs) are differentially expressed in HCC and implicate they may play distinct roles in the pathogenesis and metastasis of HCC. However, the underlying mechanisms remain largely unclear. In this review, we summarized the functions and mechanisms of those known aberrantly expressed lncRNAs identified in human HCC tissues. We hope to enlighten more comprehensive researches on the detailed mechanisms of lncRNAs and their application in clinic, such as being used as diagnostic and prognostic biomarkers and the targets for potential therapy. Although studies on lncRNAs in HCC are still deficient, an improved understanding of the roles played by lncRNAs in HCC will lead to a much more effective utilization of those lncRNAs as novel candidates in early detection, diagnosis, prevention and treatment of HCC.
authors.affiliation: Yong-Ru Liu, Rui-Xue Tang, Wen-Ting Huang, Fang-Hui Ren, Dian-Zhong Luo, Yi-Wu Dang, Gang Chen, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Yong-Ru
authors.initials: YR
authors.lastname: Liu
authors.affiliation: Yong-Ru Liu, Rui-Xue Tang, Wen-Ting Huang, Fang-Hui Ren, Dian-Zhong Luo, Yi-Wu Dang, Gang Chen, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Rui-Xue
authors.initials: RX
authors.lastname: Tang
authors.affiliation: Yong-Ru Liu, Rui-Xue Tang, Wen-Ting Huang, Fang-Hui Ren, Dian-Zhong Luo, Yi-Wu Dang, Gang Chen, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Huang
authors.affiliation: Yong-Ru Liu, Rui-Xue Tang, Wen-Ting Huang, Fang-Hui Ren, Dian-Zhong Luo, Yi-Wu Dang, Gang Chen, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Fang-Hui
authors.initials: FH
authors.lastname: Ren
authors.affiliation: Yong-Ru Liu, Rui-Xue Tang, Wen-Ting Huang, Fang-Hui Ren, Dian-Zhong Luo, Yi-Wu Dang, Gang Chen, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Rong-Quan
authors.initials: RQ
authors.lastname: He
authors.affiliation: Yong-Ru Liu, Rui-Xue Tang, Wen-Ting Huang, Fang-Hui Ren, Dian-Zhong Luo, Yi-Wu Dang, Gang Chen, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Yang
authors.affiliation: Yong-Ru Liu, Rui-Xue Tang, Wen-Ting Huang, Fang-Hui Ren, Dian-Zhong Luo, Yi-Wu Dang, Gang Chen, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Dian-Zhong
authors.initials: DZ
authors.lastname: Luo
authors.affiliation: Yong-Ru Liu, Rui-Xue Tang, Wen-Ting Huang, Fang-Hui Ren, Dian-Zhong Luo, Yi-Wu Dang, Gang Chen, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Yi-Wu
authors.initials: YW
authors.lastname: Dang
authors.affiliation: Yong-Ru Liu, Rui-Xue Tang, Wen-Ting Huang, Fang-Hui Ren, Dian-Zhong Luo, Yi-Wu Dang, Gang Chen, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
keywords: Dysregulation; Hepatocellular carcinoma; Long noncoding RNA; Mechanism; Pathway