title: The value of (18) F-fluorodeoxyglucose positron emission tomography for prediction of treatment response in gastrointestinal stromal tumors: a systematic review and meta-analysis.
abstract: BACKGROUND
  Early detection of response to treatment is critically important in gastrointestinal stromal tumors (GIST). Therefore, the present systematic review and meta-analysis assessed the value of (18) f-fluorodeoxyglucose positron emission tomography ((18) FDG-PET) on prediction of therapeutic response of GIST patients to systemic treatments.
  
  
  METHODS
  The literature search was conducted using PubMed, SCOPUS, Cochrane, and Google Scholar databases, and review article references. Eligible articles were defined as studies included confirmed GIST patients who underwent (18) FDG-PET as well as assessing the screening role of it.
  
  
  RESULTS
  Finally, 21 relevant articles were included. The analysis showed the pooled sensitivity and specificity of 18FDG-PET in evaluation of response to treatment of GIST patient were 0.90 (95% CI: 0.85-0.94; I(2)  = 52.59, P = 0.001) and 0.62 (95% CI: 0.49-0.75; I(2)  = 69.7, P = 0.001), respectively. In addition, the pooled prognostic odds ratio of (18) FDG-PET for was 14.99 (95% CI, 6.42-34.99; I(2)  = 100.0, P < 0.001). The Meta regression showed that sensitivity of (18) FDG-PET was higher if the sample size of study was equal or more than 30 cases (sensitivity = 0.93; 95% CI: 0.89-0.97), when using PET/CT (sensitivity = 0.92; 95% CI: 0.89-0.97), and self-design criteria (sensitivity = 0.93; 95% CI: 0.87-1.0).
  
  
  CONCLUSIONS
  The present meta-analysis showed (18) FDG-PET has a significant value in predicting treatment response in GIST patients.
authors.affiliation: Research Center for Nuclear Medicine, Dr Shariati Hospital, Tehran, Iran.
authors.forename: Arman
authors.initials: A
authors.lastname: Hassanzadeh-Rad
authors.affiliation: Physiology, School of Medicine, Tehran, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Yousefifard
authors.affiliation: Research Center for Nuclear Medicine, Dr Shariati Hospital, Tehran, Iran.
authors.forename: Sanaz
authors.initials: S
authors.lastname: Katal
authors.affiliation: Occupational Health Engineering, Faculty of Public Health, Tehran, Iran.
authors.forename: Hadi
authors.initials: H
authors.lastname: Asady
authors.affiliation: Research Center for Nuclear Medicine, Dr Shariati Hospital, Tehran, Iran.
authors.forename: Armaghan
authors.initials: A
authors.lastname: Fard-Esfahani
authors.affiliation: Department of Emergency Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Moghadas Jafari
authors.affiliation: Pediatric Chronic Kidney Disease Research Center, Tehran, Iran.|Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Hosseini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage*; D005770:Gastrointestinal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D046152:Gastrointestinal Stromal Tumors / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D015203:Reproducibility of Results; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Gastrointestinal stromal tumors; PET/CT; Positron emission tomography; Treatment response