title: Role of Serologic and Molecular Diagnostic Assays in Identification and Management of Hepatitis C Virus Infection.
abstract: The drugs available for the treatment of hepatitis C virus (HCV) have evolved to provide shorter treatment duration and higher rates of sustained virologic response (SVR), and the role of HCV infection diagnostic tests has had to evolve in order to meet changing clinical needs. This review gives an overview on the role of HCV infection diagnostic testing (molecular and serological tools) used in the diagnosis and management of HCV infection. All of this critical information guides physician decisions to optimize patient clinical outcomes. Also discussed is the future direction of diagnostic testing in the context of further advances in drug development.
authors.affiliation: Abbott Diagnostics, Abbott Park, Illinois, USA gavin.cloherty@abbott.com.
authors.forename: Gavin
authors.initials: G
authors.lastname: Cloherty
authors.affiliation: University at Buffalo, Buffalo, New York, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Talal
authors.affiliation: Abbott Diagnostics, Abbott Park, Illinois, USA.
authors.forename: Kelly
authors.initials: K
authors.lastname: Coller
authors.affiliation: ViiV Healthcare, Research Triangle Park, North Carolina, USA.
authors.forename: Corklin
authors.initials: C
authors.lastname: Steinhart
authors.affiliation: Abbott Diagnostics, Abbott Park, Illinois, USA.
authors.forename: John
authors.initials: J
authors.lastname: Hackett
authors.affiliation: Abbott Diagnostics, Abbott Park, Illinois, USA.
authors.forename: George
authors.initials: G
authors.lastname: Dawson
authors.affiliation: University Bonn, Bonn, Germany.
authors.forename: Juergen
authors.initials: J
authors.lastname: Rockstroh
authors.affiliation: University of Toronto, Toronto, Canada.
authors.forename: Jordan
authors.initials: J
authors.lastname: Feld
mesh_terms: D000208:Acute Disease; D000956:Antigens, Viral / Q000276:immunology; D000998:Antiviral Agents / Q000627:therapeutic use; D019468:Disease Management; D024882:Drug Resistance, Viral; D005838:Genotype; D016174:Hepacivirus / Q000145:classification* / Q000235:genetics*; D006526:Hepatitis C / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D006801:Humans; D055118:Medication Adherence; D008826:Microbial Sensitivity Tests; D025202:Molecular Diagnostic Techniques; D012367:RNA, Viral; D012698:Serologic Tests; D016896:Treatment Outcome
chemical_list: D000956:Antigens, Viral; D000998:Antiviral Agents; D012367:RNA, Viral