title: Dimensionality Reduction in Complex Medical Data: Improved Self-Adaptive Niche Genetic Algorithm.
abstract: With the development of medical technology, more and more parameters are produced to describe the human physiological condition, forming high-dimensional clinical datasets. In clinical analysis, data are commonly utilized to establish mathematical models and carry out classification. High-dimensional clinical data will increase the complexity of classification, which is often utilized in the models, and thus reduce efficiency. The Niche Genetic Algorithm (NGA) is an excellent algorithm for dimensionality reduction. However, in the conventional NGA, the niche distance parameter is set in advance, which prevents it from adjusting to the environment. In this paper, an Improved Niche Genetic Algorithm (INGA) is introduced. It employs a self-adaptive niche-culling operation in the construction of the niche environment to improve the population diversity and prevent local optimal solutions. The INGA was verified in a stratification model for sepsis patients. The results show that, by applying INGA, the feature dimensionality of datasets was reduced from 77 to 10 and that the model achieved an accuracy of 92% in predicting 28-day death in sepsis patients, which is significantly higher than other methods.
authors.affiliation: Department of Biomedical Engineering, Zhejiang University, 38 Zheda Road, Hangzhou, Zhejiang 310027, China ; Guizhou Key Laboratory of Agricultural Bioengineering, Guizhou University, Guiyang, Guizhou 550025, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Department of Biomedical Engineering, Zhejiang University, 38 Zheda Road, Hangzhou, Zhejiang 310027, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xia
authors.affiliation: Zhejiang Hospital, Hangzhou, Zhejiang 310058, China.
authors.forename: Molei
authors.initials: M
authors.lastname: Yan
authors.affiliation: Zhejiang Hospital, Hangzhou, Zhejiang 310058, China.
authors.forename: Guolong
authors.initials: G
authors.lastname: Cai
authors.affiliation: Zhejiang Hospital, Hangzhou, Zhejiang 310058, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Biomedical Engineering, Zhejiang University, 38 Zheda Road, Hangzhou, Zhejiang 310027, China.
authors.forename: Gangmin
authors.initials: G
authors.lastname: Ning
mesh_terms: D000465:Algorithms; D019295:Computational Biology; D003627:Data Interpretation, Statistical; D016208:Databases, Factual / Q000706:statistics & numerical data; D020000:Decision Support Systems, Clinical / Q000706:statistics & numerical data; D006801:Humans; D018805:Sepsis / Q000175:diagnosis / Q000401:mortality