title: Isolation of Phomopsolide A and 6(E)-Phomopsolide A as Antimycobacterial Natural Products from an Unidentified Endophyte of the Canadian Medicinal Plant Heracleum maximum.
abstract: An extract of an unidentified endophyte from the Canadian medicinal plant Heracleum maximum exhibited a unique metabolomic profile and significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra. Bioassay guided fractionation of the extract led to the isolation of phomopsolide A (1) and 6(E)-phomopsolide A (2). This is the first report of antimycobacterial activity for 1 and 2.
authors.forename: Trevor N
authors.initials: TN
authors.lastname: Clark
authors.forename: Katelyn T
authors.initials: KT
authors.lastname: Ellsworth
authors.forename: Stephanie
authors.initials: S
authors.lastname: Jean
authors.forename: Duncan
authors.initials: D
authors.lastname: Webster
authors.forename: Duncan
authors.initials: D
authors.lastname: Webste
authors.forename: Gilles A
authors.initials: GA
authors.lastname: Robichaud
authors.forename: John A
authors.initials: JA
authors.lastname: Johnson
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Gray
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products; D002170:Canada; D060026:Endophytes / Q000737:chemistry*; D030002:Heracleum / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry
chemical_list: D000995:Antitubercular Agents; D001688:Biological Products; D011753:Pyrones; C109951:phomopsolide A