title: Multiple-purpose immunotherapy for cancer.
abstract: Anti-cancer vaccination is a useful strategy to elicit antitumor immune responses, while overcoming immunosuppressive mechanisms. Whole tumor cells or lysates derived thereof hold more promise as cancer vaccines than individual tumor-associated antigens (TAAs), because vaccinal cells can elicit immune responses to multiple TAAs. Cancer cell-based vaccines can be autologous, allogeneic or xenogeneic. Clinical use of xenogeneic vaccines is advantageous in that they can be most effective in breaking the preexisting immune tolerance to TAAs. An attractive protocol would be to combine vaccinations with immunostimulating and/or immunosuppression-blocking modalities. It is reasonable to anticipate that combined immunotherapeutic strategies will allow for substantial improvements in clinical outcomes in the near future.
authors.affiliation: lmmanuel Kant Baltic Federal University, 3 Botkin str., 236016 Kaliningrad, Russia. Electronic address: seledtsov@rambler.ru.
authors.forename: V I
authors.initials: VI
authors.lastname: Seledtsov
authors.affiliation: lmmanuel Kant Baltic Federal University, 3 Botkin str., 236016 Kaliningrad, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Goncharov
authors.affiliation: Institute of Clinical Immunology, 14 Ydrintsevskaya str., 630099 Novosibirsk, Russia.
authors.forename: G V
authors.initials: GV
authors.lastname: Seledtsova
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D019496:Cancer Vaccines / Q000008:administration & dosage*; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines
keywords: Antitumor immunoprotection; Cancer cell-based vaccines; Combined immunotherapy; Immunosuppression