title: Association analysis of DISC1 gene polymorphisms with Attention-Deficit Hyperactivity Disorder in Iranian population.
abstract: OBJECTIVE
  Attention deficit hyperactivity disorder (ADHD) is a common heritable psychiatric disorder with a worldwide prevalence of 5%. The etiology of ADHD is still incompletely understood, but several studies, consistently indicate the strong role of genetic factors on this disorder. The aim of this study was to determine the effect of three SNPs rs11122319, rs11122330 and rs6675281 in the etiology of ADHD in an Iranian children.
  
  
  METHODS
  In this research work, for the first time, we investigated the association of three SNPs (rs11122330, rs6675281 and rs11122319) in the DISC1 gene with ADHD in Iranian population. Two hundred fourthy subjects composed of 120 patients and 120 healthy controls were included and tetra-primer ARMS PCR technique was used for genotyping all selected SNPs.
  
  
  RESULTS
  We found differences in genotype and allele distributions of rs 6675281 polymorphism between our patients and controls. The A, T and A alleles were the more frequent alleles in rs11122319, rs6675281 and rs11122330 polymorphisms in both case and control groups respectively. The TT genotype was more frequent in control group compared to patients. (P value = 0.008, OR= 1.5837, 95% CI= 1.1012 to 2.2776).
  
  
  CONCLUSIONS
  Our findings strengthens the role of DISC1 gene as a susceptibility locus for ADHD and indicate that rs6675281 polymorphism is a susceptibility factor for ADHD for the first time in children reported in an Iranian population in this part of the world.
authors.affiliation: Matin Kayyal, Department of Molecular Genetics, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Matin
authors.initials: M
authors.lastname: Kayyal
authors.affiliation: Abolfazl Movafagh, Dept. of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Movafagh
authors.affiliation: Mehrdad Hashemi, Department of Molecular Genetics, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Hashemi
authors.affiliation: Arezou Sayad, Dept. of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Arezou
authors.initials: A
authors.lastname: Sayad
authors.affiliation: Babak Emamalizadeh, Dept. of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Emamalizadeh
authors.affiliation: Khashayar pourIran, Dept. of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Khashayar
authors.initials: K
authors.lastname: PourIran
authors.affiliation: Mohammadmoien Kayyal, Department of Molecular Genetics, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Mohammadmoien
authors.initials: M
authors.lastname: Kayyal
authors.affiliation: Mohammad Reza Eslami Amirabadi, Department of Psychiatry, Imam Hossein Medical Hospital, Shahid Behashti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Reza Eslami
authors.initials: MR
authors.lastname: Amirabadi
authors.affiliation: Mahdi Zamani Department of Medical Genetics, School of Medicine, Department of Neurology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Zamani
authors.affiliation: Hossein Darvish, Dept. of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Darvish
keywords: ADHD; Association; DISC1 gene; Hyperactivity; Iran; polymorphisms