title: Modeling neurodevelopmental cognitive deficits in tasks with cross-species translational validity.
abstract: Numerous psychiatric disorders whose cognitive dysfunction links to functional outcome have neurodevelopmental origins including schizophrenia, autism and bipolar disorder. Treatments are needed for these cognitive deficits, which require development using animal models. Models of neurodevelopmental disorders are as varied and diverse as the disorders themselves, recreating some but not all aspects of the disorder. This variety may in part underlie why purported procognitive treatments translated from these models have failed to restore functioning in the targeted patient populations. Further complications arise from environmental factors used in these models that can contribute to numerous disorders, perhaps only impacting specific domains, while diagnostic boundaries define individual disorders, limiting translational efficacy. The Research Domain Criteria project seeks to 'develop new ways to classify mental disorders based on behavioral dimensions and neurobiological measures' in hopes of facilitating translational research by remaining agnostic toward diagnostic borders derived from clinical presentation in humans. Models could therefore recreate biosignatures of cognitive dysfunction irrespective of disease state. This review highlights work within the field of neurodevelopmental models of psychiatric disorders tested in cross-species translational cognitive paradigms that directly inform this newly developing research strategy. By expounding on this approach, the hopes are that a fuller understanding of each model may be attainable in terms of the cognitive profile elicited by each manipulation. Hence, conclusions may begin to be drawn on the nature of cognitive neuropathology on neurodevelopmental and other disorders, increasing the chances of procognitive treatment development for individuals affected in specific cognitive domains.
authors.affiliation: Department of Psychiatry, University of California San Diego, La Jolla.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Cope
authors.affiliation: Department of Psychiatry, University of California San Diego, La Jolla.|Research Service, VA San Diego Healthcare System, San Diego, CA, USA.
authors.forename: S B
authors.initials: SB
authors.lastname: Powell
authors.affiliation: Department of Psychiatry, University of California San Diego, La Jolla.|Research Service, VA San Diego Healthcare System, San Diego, CA, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Young
mesh_terms: D000818:Animals; D003072:Cognition Disorders / Q000235:genetics* / Q000503:physiopathology; D002658:Developmental Disabilities / Q000235:genetics* / Q000503:physiopathology; D004195:Disease Models, Animal; D059647:Gene-Environment Interaction; D006801:Humans; D055495:Neurogenesis; D013045:Species Specificity
keywords: CNTRICS; Research Domain Criteria; cognition; cross-species; developmental; mice; motivation; rats; translational