title: The state of regional therapy in the management of metastatic colorectal cancer to the liver.
abstract: Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality in the United States. Most colorectal cancer patients die from advanced disease, and two-thirds of CRC deaths are due to liver metastases. Liver resection provides the best curative option for patients with colorectal liver metastases (CRLM), yet only 20% of those patients are eligible for liver metastases resection for curative intent. Loco-regional treatment of CRLM may provide additional benefits in terms of down-staging for resection and prolonged hepatic disease control. This review focusses on hepatic arterial infusion, radioembolization and chemoembolization.
authors.affiliation: a Department of Medical Oncology , City of Hope National Medical Center , Duarte , CA , USA.
authors.forename: May
authors.initials: M
authors.lastname: Cho
authors.affiliation: a Department of Medical Oncology , City of Hope National Medical Center , Duarte , CA , USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Gong
authors.affiliation: a Department of Medical Oncology , City of Hope National Medical Center , Duarte , CA , USA.
authors.forename: Marwan
authors.initials: M
authors.lastname: Fakih
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D016461:Chemoembolization, Therapeutic / Q000379:methods; D015179:Colorectal Neoplasms / Q000473:pathology*; D004621:Embolization, Therapeutic / Q000379:methods*; D006498:Hepatectomy / Q000379:methods; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents
keywords: Regional therapy; chemoembolization; hepatic artery infusion; liver metastases; radioembolization