title: Efficacy of Additional Dutasteride on Lower Urinary Tract Symptoms in Patients with Alpha-1 Blocker-Resistant Benign Prostatic Hyperplasia.
abstract: OBJECTIVE
  We investigated the effects of dutasteride on urination and quality of life (QOL) in patients diagnosed with benign prostatic hyperplasia (BPH) who showed poor improvement in lower urinary tract symptoms (LUTS) with alpha-1 blockers.
  
  
  METHODS
  We retrospectively analyzed 108 patients with BPH who took dutasteride for more than 3 months from October 2009 to October 2011. The patients showed poor improvement in LUTS despite administration of alpha-1 blockers for more than 3 months; all had an International Prostate Symptom Score (IPSS) of eight or greater. We investigated changes in prostate-specific antigen and prostate volume and performed uroflowmetry and medical interviews to assess IPSS-QOL score and BPH impact index (BII).
  
  
  RESULTS
  Mean prostate volume was 52.8 ± 22.2 mL, and the mean period of dutasteride administration was 284 ± 118 days. Prostate volume decreased 24.1% from baseline to 6 months after administration. Voiding symptoms and storage symptoms showed improvements with longer administration periods, but only nocturia showed no clear improvement. There was a 0.9-point decrease in BII after 6 months. There was no statistically significant association between the rate of prostate volume reduction and improvement in voiding and storage symptoms.
  
  
  CONCLUSIONS
  Additional administration of dutasteride to patients with alpha-1 blocker-resistant BPH led to improvements in all voiding and storage symptoms except nocturia, and showed no correlation between the prostate volume reduction rates and improvement in LUTS.
authors.affiliation: Department of Urology, Japanese Red Cross Otsu Hospital, Shiga, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sengiku
authors.affiliation: Department of Urology, Japanese Red Cross Otsu Hospital, Shiga, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Miyazaki
authors.affiliation: Department of Urology, Japanese Red Cross Otsu Hospital, Shiga, Japan.
authors.forename: Harutake
authors.initials: H
authors.lastname: Sawazaki
authors.affiliation: Department of Urology, Japanese Red Cross Otsu Hospital, Shiga, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Department of Urology, Japanese Red Cross Otsu Hospital, Shiga, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Ogura
keywords: dutasteride; nocturia prostate; prostatic hyperplasia