title: Novel Molecular Approaches in Heart Failure: Seven Trans-Membrane Receptors Signaling in the Heart and Circulating Blood Leukocytes.
abstract: Heart failure (HF) is the result of molecular, cellular, and structural changes induced by cardiac load or injury. A complex network of signaling pathways have been involved in the development and progression of cardiac dysfunction. In this review, we summarize the pivotal role of seven trans-membrane receptors (7TMRs), also called G-protein-coupled receptors (GPCRs), in HF. Moreover, we will discuss the current knowledge on the potential mirroring of 7TMR signaling between circulating blood leukocytes and the heart, and the related future possibilities in the management of HF patients.
authors.affiliation: Department of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
authors.forename: Gabriele Giacomo
authors.initials: GG
authors.lastname: Schiattarella
authors.affiliation: Department of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Magliulo
authors.affiliation: Department of Advanced Biomedical Sciences, Federico II University , Naples , Italy ; Department of Molecular Medicine and Medical Biotechnology, Federico II University , Naples , Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Cattaneo
authors.affiliation: Department of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gargiulo
authors.affiliation: Department of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Sannino
authors.affiliation: Department of Cardiology, Swiss Cardiovascular Center Bern , Bern , Switzerland.
authors.forename: Anna
authors.initials: A
authors.lastname: Franzone
authors.affiliation: Department of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Oliveti
authors.affiliation: Department of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Perrino
authors.affiliation: Department of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Trimarco
authors.affiliation: Department of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Esposito
keywords: cardiac remodeling; heart failure; leukocytes; seven trans-membrane receptors