title: microRNAs: Key Players in Hematopoiesis.
abstract: microRNAs (miRNAs) are small length noncoding RNAs which play a key role in cellular processes such as proliferation, differentiation, and development of lineage hematopoietic cells and matured blood cells. Aberrant expression of miRNAs has been reported in several hematopoietic disorders. The involvement of miRNAs in regulation of various signaling pathways has been shown in hematopoietic disorders. Along with regulatory role, miRNAs are also proven as diagnostic and prognostic markers for these malignancies. Recent studies are evidenced that the miRNA are key regulators of hematopoietic disorders and progression of these disorders shows the importance of targeting the aberrant expression of miRNAs as new therapeutic interventions. The present chapter provides overview of the art related to the importance of miRNAs in developmental hematopoiesis and pathogenesis of hematopoietic disorders including chronic lymphocytic leukemia, chronic myelogenous leukemia, multiple myelomas, and B cell lymphomas.
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad, Telangana, 500 046, India.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Raghuwanshi
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad, Telangana, 500 046, India.
authors.forename: Hanuma Kumar
authors.initials: HK
authors.lastname: Karnati
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad, Telangana, 500 046, India.
authors.forename: Shilpa
authors.initials: S
authors.lastname: Sarvothaman
authors.affiliation: Department of Biotechnology, GITAM Institute of Science, Gandhi Institute of Technology and Management (GITAM) University, Visakhapatnam, Andhra Pradesh, 530 045, India.
authors.forename: Usha
authors.initials: U
authors.lastname: Gutti
authors.affiliation: Department of Biotechnology, GITAM Institute of Science, Gandhi Institute of Technology and Management (GITAM) University, Visakhapatnam, Andhra Pradesh, 530 045, India.
authors.forename: Raja Gopal Venakata
authors.initials: RG
authors.lastname: Saladi
authors.affiliation: Fernandez Hospital Pvt. Ltd., Bogulkunta, Hyderabad, Telangana, 500 001, India.
authors.forename: Prathibha Reddy
authors.initials: PR
authors.lastname: Tummala
authors.affiliation: Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad, Telangana, 500 046, India. guttiravi@gmail.com.
authors.forename: Ravi Kumar
authors.initials: RK
authors.lastname: Gutti
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006410:Hematopoiesis; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008223:Lymphoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009101:Multiple Myeloma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: D035683:MicroRNAs
keywords: B cell lymphomas; Chronic lymphocytic leukemia; Chronic myelogenous leukemia; Hematopoietic disorders; Multiple myelomas; miRNA