title: DNA repair gene XRCC3 T241M polymorphism and susceptibility to hepatocellular carcinoma in a Chinese population: a meta-analysis.
abstract: Numerous studies have evaluated the association between the X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3) T241M polymorphism and hepatocellular carcinoma (HCC) risk. However, the results of such investigations have proved inconsistent. Therefore, we performed a meta-analysis of the association between this polymorphism and HCC risk in the Chinese population. Published literature from PubMed and China National Knowledge Infrastructure databases was retrieved, and a total of 5 case-control studies consisting of 2967 patients and 3874 controls were included in this meta-analysis, which revealed a significant association between the XRCC3 T241M polymorphism and HCC risk (TT vs MM: OR = 6.54, 95%CI = 2.14-19.99; TT vs MT: OR = 4.72, 95%CI = 2.26-9.86; dominant model: OR = 0.38, 95%CI = 0.26-0.57; recessive model: OR = 1.27, 95%CI = 0.99-1.62). In a subgroup analysis by sample size (number of subjects > 1000), similar results were obtained. Thus, XRCC3 T241M polymorphism may constitute a risk factor for HCC in the Chinese population.
authors.affiliation: Liver Disease Research Center, Ningbo No. 2 Hospital, Ningbo, Zheijiang, China.
authors.forename: R B
authors.initials: RB
authors.lastname: Ji
authors.affiliation: Liver Disease Research Center, Ningbo No. 2 Hospital, Ningbo, Zheijiang, China.
authors.forename: Y S
authors.initials: YS
authors.lastname: Qian
authors.affiliation: Liver Disease Research Center, Ningbo No. 2 Hospital, Ningbo, Zheijiang, China huairong1970@126.com.
authors.forename: A R
authors.initials: AR
authors.lastname: Hu
authors.affiliation: Liver Disease Research Center, Ningbo No. 2 Hospital, Ningbo, Zheijiang, China.
authors.forename: Y R
authors.initials: YR
authors.lastname: Hu
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003062:Codon; D004260:DNA Repair / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk
chemical_list: D003062:Codon; D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3