title: Impaired Frontal-Basal Ganglia Connectivity in Male Adolescents with Conduct Disorder.
abstract: Alack of inhibition control has been found in subjects with conduct disorder (CD), but the underlying neuropathophysiology remains poorly understood. The current study investigated the different mechanism of inhibition control in adolescent-onset CD males (n = 29) and well-matched healthy controls (HCs) (n = 40) when performing a GoStop task by functional magnetic resonance images. Effective connectivity (EC) within the inhibition control network was analyzed using a stochastic dynamic causality model. We found that EC within the inhibition control network was significantly different in the CD group when compared to the HCs. Exploratory relationship analysis revealed significant negative associations between EC between the IFG and striatum and behavioral scale scores in the CD group. These results suggest for the first time that the failure of inhibition control in subjects with CD might be associated with aberrant connectivity of the frontal-basal ganglia pathways, especially between the IFG and striatum.
authors.affiliation: Department of Psychology, School of Education, Jianghan University, Wuhan, Hubei, China.|Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Jibiao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: School of Biomedical Engineering, Fourth Military Medical University, Xi'an, Shaanxi, China.
authors.forename: Baojuan
authors.initials: B
authors.lastname: Li
authors.affiliation: Centre of Buddhist Studies, University of Hong Kong, Hong Kong, China.
authors.forename: Junling
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Psychology, Shanghai Normal University, Shanghai, China.
authors.forename: Huqing
authors.initials: H
authors.lastname: Shi
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Qingsen
authors.initials: Q
authors.lastname: Ming
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Yidian
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Ren
authors.initials: R
authors.lastname: Ma
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.|National Technology Institute of Psychiatry, Changsha, Hunan, China.
authors.forename: Shuqiao
authors.initials: S
authors.lastname: Yao
mesh_terms: D000293:Adolescent; D001519:Behavior; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D019955:Conduct Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways; D011859:Radiography