title: Flaxseed flour (Linum usitatissinum) consumption improves bone quality and decreases the adipocyte area of lactating rats in the post-weaning period.
abstract: The aim of this work was to evaluate the effects of flaxseed flour in the intake on adiposity and femur structure of the lactating rats during the post-weaning period. After weaning, the lactating rats were divided into control (C, n = 6) and experimental (F, n = 6) groups treated with a diet containing flaxseed flour. Serum hormone and fatty acids composition, morphology of intra-abdominal adipocytes, computed tomography and biomechanical analyses of femur were determined. Food intake, body mass and hormone analysis have shown similar results. The F group showed the following (p < 0.05): lower arachidonic acid (-60%), total polyunsaturated fatty acids (-30%) and retroperitoneal adipocytes (-36%) area. Higher radiodensity of femoral head region (+29%) and higher maximum force (+18%), breaking strength (+18%) and rigidity (+31%). Fatty acid composition of flaxseed flour decreased the area of adipocytes and improved the bone quality, which may be associated with lower serum levels of arachidonic acid levels, during the post-weaning period.
authors.affiliation: a Department of Nutrition and Dietetics, Faculty of Nutrition, Laboratory of Experimental Nutrition , Federal Fluminense University , Niterói , RJ , Brazil ;
authors.forename: Danielle Cavalcante
authors.initials: DC
authors.lastname: Ribeiro
authors.affiliation: a Department of Nutrition and Dietetics, Faculty of Nutrition, Laboratory of Experimental Nutrition , Federal Fluminense University , Niterói , RJ , Brazil ;
authors.forename: Aline D'Avila
authors.initials: AD
authors.lastname: Pereira
authors.affiliation: a Department of Nutrition and Dietetics, Faculty of Nutrition, Laboratory of Experimental Nutrition , Federal Fluminense University , Niterói , RJ , Brazil ;
authors.forename: Paula Cristina Alves
authors.initials: PC
authors.lastname: da Silva
authors.affiliation: b Department of Physiological Sciences , Institute of Biology Roberto Alcantara Gomes, State University of Rio De Janeiro , Rio De Janeiro , RJ , Brazil ;
authors.forename: Aline de Sousa
authors.initials: Ade S
authors.lastname: dos Santos
authors.affiliation: c Department of Food Science and Experimental Nutrition, Faculty of Pharmaceutical Sciences, Laboratory of Lipids , University of São Paulo , São Paulo , SP , Brazil ;
authors.forename: Fernanda Carvalho
authors.initials: FC
authors.lastname: de Santana
authors.affiliation: a Department of Nutrition and Dietetics, Faculty of Nutrition, Laboratory of Experimental Nutrition , Federal Fluminense University , Niterói , RJ , Brazil ;
authors.forename: Bianca Ferolla da Camara
authors.initials: BF
authors.lastname: Boueri
authors.affiliation: a Department of Nutrition and Dietetics, Faculty of Nutrition, Laboratory of Experimental Nutrition , Federal Fluminense University , Niterói , RJ , Brazil ;
authors.forename: Carolina Ribeiro
authors.initials: CR
authors.lastname: Pessanha
authors.affiliation: a Department of Nutrition and Dietetics, Faculty of Nutrition, Laboratory of Experimental Nutrition , Federal Fluminense University , Niterói , RJ , Brazil ;
authors.forename: Maíra Duque Coutinho
authors.initials: MD
authors.lastname: de Abreu
authors.affiliation: c Department of Food Science and Experimental Nutrition, Faculty of Pharmaceutical Sciences, Laboratory of Lipids , University of São Paulo , São Paulo , SP , Brazil ;
authors.forename: Jorge
authors.initials: J
authors.lastname: Mancini-Filho
authors.affiliation: d Analytical Laboratory of Restorative Biomaterials , Dental School, Federal Fluminense University , Niterói , RJ , Brazil.
authors.forename: Eduardo Moreira
authors.initials: EM
authors.lastname: da Silva
authors.affiliation: b Department of Physiological Sciences , Institute of Biology Roberto Alcantara Gomes, State University of Rio De Janeiro , Rio De Janeiro , RJ , Brazil ;
authors.forename: Celly Cristina Alves
authors.initials: CC
authors.lastname: do Nascimento-Saba
authors.affiliation: a Department of Nutrition and Dietetics, Faculty of Nutrition, Laboratory of Experimental Nutrition , Federal Fluminense University , Niterói , RJ , Brazil ;
authors.forename: Carlos Alberto Soares
authors.initials: CA
authors.lastname: da Costa
authors.affiliation: a Department of Nutrition and Dietetics, Faculty of Nutrition, Laboratory of Experimental Nutrition , Federal Fluminense University , Niterói , RJ , Brazil ;
authors.forename: Gilson Teles
authors.initials: GT
authors.lastname: Boaventura
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D016718:Arachidonic Acid / Q000097:blood; D015519:Bone Density; D004032:Diet; D005227:Fatty Acids / Q000097:blood / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005269:Femur / Q000187:drug effects* / Q000378:metabolism; D019597:Flax / Q000737:chemistry*; D005433:Flour; D007774:Lactation; D009765:Obesity / Q000097:blood / Q000378:metabolism* / Q000517:prevention & control; D010024:Osteoporosis / Q000097:blood / Q000378:metabolism* / Q000517:prevention & control; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*; D014886:Weaning
chemical_list: D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D016718:Arachidonic Acid
keywords: Biomechanical; chromatography; diet; femur; polyunsaturated fatty acids