title: Clinical significance and expression of the PRSS3 and Wiskott-Aldrich syndrome protein family verprolin-homologous protein 1 for the early detection of epithelial ovarian cancer.
abstract: In this study, we evaluate the clinical significance of the PRSS3 and Wiskott-Aldrich syndrome protein family verprolin-homologous protein 1 (WAVE1) in patients with epithelial ovarian cancer (EOC) by immunohistochemistry.In current study, all adjacent non-cancerous tissues showed absent or low expression of PRSS3. The expression of PRSS3 was significantly increased in the EOCs than adjacent non-cancerous tissues. Moreover, the expression of WAVE1 was significantly observed in all EOC tissues when compared with normal tissues. Furthermore, WAVE1 expression was absent in 35 (89.74 %) adjacent non-cancerous tissues.Our findings showed that high expression of PRSS3 was markedly linked to FIGO stage (P = 0.02), advanced grade (P = 0.017), and lymph node metastases (P = 0.001), but no relationship was determined with other clinicopathological parameters. Furthermore, high expression of WAVE1 was significantly correlated with FIGO stage (P = 0.001), grade of tumor (P = 0.011), and residual tumor size (P = 0.041), but no significant associations were found between WAVE1 expression and age, lymph node metastasis, and histological subtypes (all P > 0.05). In conclusion, our study showed that increased expression of PRSS3 and WAVE1 may be involved in development of EOC.
authors.affiliation: Department of Gynecology, Hajar Hospital, AJA University of Medical Sciences, Tehran, Iran.
authors.forename: Sima
authors.initials: S
authors.lastname: Azizmohammadi
authors.affiliation: Department of Gynecology, Imam Reza Hospital, AJA University of Medical Sciences, Tehran, Iran.
authors.forename: Aghdas
authors.initials: A
authors.lastname: Safari
authors.affiliation: Department of Gynecology, Khanevadeh Hospital, AJA University of Medical Sciences, Tehran, Iran.
authors.forename: Mehri
authors.initials: M
authors.lastname: Seifoleslami
authors.affiliation: Shahid Abbas Abdollahi, Molecular Biology Research Center, Shahid Mahallati Hospital, Tabriz, Iran.
authors.forename: Rahman Ghaffarzadegan
authors.initials: RG
authors.lastname: Rabati
authors.affiliation: Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Mohammadi
authors.affiliation: Department of Molecular Biology, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Yahaghi
authors.affiliation: Department of Gynecology, Hajar Hospital, AJA University of Medical Sciences, Tehran, Iran. dr.azizmohamadi@gmail.com.
authors.forename: Susan
authors.initials: S
authors.lastname: Azizmohammadi
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D000077216:Carcinoma, Ovarian Epithelial; D055088:Early Detection of Cancer; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008875:Middle Aged; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis* / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D011379:Prognosis; D014357:Trypsin / Q000235:genetics / Q000378:metabolism*; D051300:Wiskott-Aldrich Syndrome Protein Family / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D051300:Wiskott-Aldrich Syndrome Protein Family; C040749:PRSS3 protein, human; D014357:Trypsin
keywords: Epithelial ovarian cancer; Expression; PRSS3; Tissues; WAVE1