title: Synthesis of Multiring Fused 2-Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α-Synuclein Amyloid Formation.
abstract: An efficient, straightforward method for the synthesis of thiazolo-2-pyridone embedded peptidomimetic polyheterocycles via a catalyst-free, microwave-assisted, intramolecular C-H amination reaction is reported. All the synthesized polyheterocycles were evaluated for their fluorescent properties and effect on α-synuclein amyloid formation.
authors.affiliation: Umeå University , Department of Chemistry, 90187 Umeå, Sweden.
authors.forename: Pardeep
authors.initials: P
authors.lastname: Singh
authors.affiliation: Umeå University , Department of Chemistry, 90187 Umeå, Sweden.
authors.forename: Erik
authors.initials: E
authors.lastname: Chorell
authors.forename: K Syam
authors.initials: KS
authors.lastname: Krishnan
authors.affiliation: Umeå University , Department of Chemistry, 90187 Umeå, Sweden.
authors.forename: Tomas
authors.initials: T
authors.lastname: Kindahl
authors.affiliation: Umeå University , Department of Chemistry, 90187 Umeå, Sweden.
authors.forename: Jörgen
authors.initials: J
authors.lastname: Åden
authors.affiliation: Umeå University , Department of Chemistry, 90187 Umeå, Sweden.
authors.forename: Pernilla
authors.initials: P
authors.lastname: Wittung-Stafshede
authors.affiliation: Umeå University , Department of Chemistry, 90187 Umeå, Sweden.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Almqvist
mesh_terms: D000586:Amination; D002384:Catalysis; D005453:Fluorescence; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051844:alpha-Synuclein / Q000187:drug effects*
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; D007097:Imines; D011728:Pyridones; D013844:Thiazoles; D051844:alpha-Synuclein; C017621:phenylnitrene