title: Low Serum Amylase is Associated with Gestational Diabetes Mellitus in Chinese Pregnant Women.
abstract: BACKGROUND
  The association between low serum amylase levels and type 2 diabetes mellitus and metabolic syndrome has been clearly disclosed. However, the relationship between serum amylase levels and gestational diabetes mellitus (GDM) has not been extensively studied. This study aimed to assess the association of serum amylase with GDM.
  
  
  METHODS
  A cross-sectional study was performed among 878 Chinese pregnant women who underwent detailed prenatal visits in Hangzhou, China.
  
  
  RESULTS
  A total of 108 (12.30%) subjects fulfilled the diagnostic criteria of GDM. Patients with GDM had significantly lower levels of serum amylase than those without GDM. The prevalence rate of GDM decreased across serum amylase increasing tertiles (p for trend < 0.001). Correlation analysis showed that serum amylase level was negatively correlated with fasting plasma glucose, 1hPG, 2hPG, HOMA-IR, triglyceride, free fatty acid, and thyroid stimulating hormone (all with p < 0.05). Multiple logistic regression showed that low serum amylase level predicted increased risk of GDM.
  
  
  CONCLUSIONS
  Our findings suggest that low serum amylase level is significantly associated with increased risk of GDM.
authors.forename: Ruoheng
authors.initials: R
authors.lastname: Zheng
authors.forename: Juanwen
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhao
authors.initials: Z
authors.lastname: Ying
authors.forename: Nengneng
authors.initials: N
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000681:Amylases / Q000097:blood* / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D002681:China; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000097:blood / Q000378:metabolism; D011247:Pregnancy; D015995:Prevalence; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D000681:Amylases