title: [The prognostic role of expression of p16 tumor suppressor gene in Hungarian patients with oral squamous cell carcinoma].
abstract: Beside smoking and alcohol consumption, human papillomavirus (HPV) infection is the most common risk factor of squamous cell carcinoma in the head and neck region (HNSCC). The latter group of patients associates with better prognosis. During HPV infection, the level of p16 tumor suppressor elevates, which could give an additional opportunity for diagnosis: instead of molecular diagnostic tools, the application of immunohistochemistry is acceptable. However, the majority of the published studies focused on the whole head and neck region and did not separately handled cancers of the oral cavity. Our recent work analyzed the expression of p16 in 67 oral squamous cancers, and compared to routine clinicopathologic parameters. From surgical samples tissue microarray blocks were prepared and expression of p16 as well as other molecular markers (p53, Ki67, EGFR) were studied. In contrast to previous studies on HNSCC, with the exception of recurrence, the expression of p16 was not found associated to clinicopathologic parameters. Nuclear stabilization of p53 appeared mainly in younger patients. The expression of p53 and EGFR significantly correlated to each other. We concluded that traditional molecular categorization of HNSCC could not be completely adaptable to Hungarian samples. Potential coexposition of common etiological factors (e.g. HPV, smoking, alcohol) could blur borders between distinct categories.
authors.affiliation: II. Sz. Patológia Intézet, Semmelweis Egyetem, Budapest, Hungary. steveken12@yahoo.com.
authors.forename: Judit Borbála
authors.initials: JB
authors.lastname: Vánkos
authors.affiliation: II. Sz. Patológia Intézet, Semmelweis Egyetem, Budapest, Hungary. steveken12@yahoo.com.
authors.forename: Violetta
authors.initials: V
authors.lastname: Piurkó
authors.affiliation: Arc-, Állcsont-, Szájsebészeti és Fogászati Klinika, Semmelweis Egyetem, Budapest, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Suba
authors.affiliation: Arc-, Állcsont-, Szájsebészeti és Fogászati Klinika, Semmelweis Egyetem, Budapest, Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Németh
authors.affiliation: II. Sz. Patológia Intézet, Semmelweis Egyetem, Budapest, Hungary. steveken12@yahoo.com.
authors.forename: József
authors.initials: J
authors.lastname: Tímár
authors.affiliation: Nemzeti Rákregiszter és Biostatisztikai Központ, Országos Onkológiai Intézet, Budapest, Hungary.
authors.forename: István
authors.initials: I
authors.lastname: Kenessey