title: Multifunctional Bismuth Selenide Nanocomposites for Antitumor Thermo-Chemotherapy and Imaging.
abstract: To integrate real-time monitoring and therapeutic functions into a single nanoagent, we have designed and synthesized a drug-delivery platform based on a polydopamine(PDA)/human serum albumin (HSA)/doxorubicin (DOX) coated bismuth selenide (Bi2Se3) nanoparticle (NP). The resultant product exhibits high stability and biocompatibility both in vitro and in vivo. In addition to the excellent capability for both X-ray computed tomography (CT) and infrared thermal imaging, the NPs possess strong near-infrared (NIR) absorbance, and high capability and stability of photothermal conversion for efficient photothermal therapy (PTT) applications. Furthermore, a bimodal on-demand pH/photothermal-sensitive drug release has been achieved, resulting in a significant chemotherapeutic effect. Most importantly, the tumor-growth inhibition ratio achieved from thermo-chemotherapy of the Bi2Se3@PDA/DOX/HSA NPs was 92.6%, in comparison to the chemotherapy (27.8%) or PTT (73.6%) alone, showing a superior synergistic therapeutic effect. In addition, there is no noticeable toxicity induced by the NPs in vivo. This multifunctional platform is, therefore, promising for effective, safe and precise antitumor treatment and may stimulate interest in further exploration of drug loading on Bi2Se3 and other competent PTT agents combined with in situ imaging for biomedical applications.
authors.affiliation: State Key Laboratory of Urban Water Resource and Environment, School of Chemical Engineering and Technology, Harbin Institute of Technology , Harbin 150000, China.|Condensed Matter Science and Technology Institute, Harbin Institute of Technology , Harbin 150000, China.|Interdisciplinary Nanoscience Center (iNANO) and Department of Physics and Astronomy, Aarhus University , Aarhus 8000, Denmark.
authors.forename: Zhenglin
authors.initials: Z
authors.lastname: Li
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology , Harbin 150000, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Interdisciplinary Nanoscience Center (iNANO) and Department of Physics and Astronomy, Aarhus University , Aarhus 8000, Denmark.
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Howard
authors.affiliation: State Key Laboratory of Urban Water Resource and Environment, School of Chemical Engineering and Technology, Harbin Institute of Technology , Harbin 150000, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Urban Water Resource and Environment, School of Chemical Engineering and Technology, Harbin Institute of Technology , Harbin 150000, China.
authors.forename: Xuelei
authors.initials: X
authors.lastname: Fan
authors.affiliation: School of Materials Science and Engineering, Harbin Institute of Technology , Harbin 150000, China.
authors.forename: Zhaohua
authors.initials: Z
authors.lastname: Miao
authors.affiliation: Condensed Matter Science and Technology Institute, Harbin Institute of Technology , Harbin 150000, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Interdisciplinary Nanoscience Center (iNANO) and Department of Physics and Astronomy, Aarhus University , Aarhus 8000, Denmark.
authors.forename: Flemming
authors.initials: F
authors.lastname: Besenbacher
authors.affiliation: State Key Laboratory of Urban Water Resource and Environment, School of Chemical Engineering and Technology, Harbin Institute of Technology , Harbin 150000, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Yu
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001729:Bismuth / Q000737:chemistry / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology; D004339:Drug Compounding; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D005260:Female; D006367:HeLa Cells; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced / Q000379:methods; D007211:Indoles / Q000737:chemistry; D051379:Mice; D008819:Mice, Nude; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D009368:Neoplasm Transplantation; D010789:Phototherapy / Q000379:methods*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D018036:Selenium Compounds / Q000737:chemistry / Q000494:pharmacology*; D014183:Transplantation, Heterologous; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D000903:Antibiotics, Antineoplastic; D007211:Indoles; D011108:Polymers; D018036:Selenium Compounds; C568283:polydopamine; D011092:Polyethylene Glycols; D004317:Doxorubicin; D001729:Bismuth
keywords: bioimaging; bismuth selenide nanoparticle; drug delivery; multifunctional nanocomposite; photothermal therapy