title: Transcutaneous posterior tibial nerve stimulation versus extended release oxybutynin in overactive bladder patients. A prospective randomized trial.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effectiveness of transcutaneous posterior tibial nerve stimulation (T.C. PTNS) versus extended release oxybutynin (E.R.O.) in patients with overactive bladder.
  
  
  METHODS
  Seventy female patients were randomized to receive either 10mg E.R.O. daily or T.C. PTNS, using a TENS machine program with the 20Hz, 200 cycles/s, and normal stimulation setting for two 30-min sessions, each week for a 12-week period. Pre-treatment and after the 12-week intervention, each patient completed a 3-day voiding diary and a self-report quality of life questionnaire (OAB-q). Statistical analysis was performed using Stata V12.1.
  
  
  RESULTS
  Sixty-four patients completed the treatment protocol. There were no significant differences between study groups in terms of age, body mass index, past hormone replacement therapy, smoking habits, menopause status, and parity. Prior to treatment, there were also no significant differences in the analysis of the 3-day voiding diary or in the OAB-q questionnaire results. Following the 12-week study, there was a statistically significant reduction in frequency of urination, urgency episodes, and urge incontinent episodes compared to pre-treatment values. However, there were no significant differences in these values between intervention groups after 12-weeks of therapy. There was a similar improvement in OAB-q scores in both treatment groups following therapy, and the T.C. PTNS group showed a statistically significant improvement over the E.R.O. in domain 2 of the OAB-q questionnaire. The other two domains showed similar improvement in both study groups.
  
  
  CONCLUSIONS
  T.C. PTNS and E.R.O. demonstrated similar improvements in subjects with OAB in a 12-week study.
authors.affiliation: Pelvic Floor Unit, Obstetrics and Gynecology Department, Clinical Hospital, Universidad de Chile, Chile. Electronic address: valentinmanriquez@gmail.com.
authors.forename: Valentín
authors.initials: V
authors.lastname: Manríquez
authors.affiliation: Pelvic Floor Unit, Obstetrics and Gynecology Department, Clinical Hospital, Universidad de Chile, Chile.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Guzmán
authors.affiliation: Pelvic Floor Unit, Obstetrics and Gynecology Department, Clinical Hospital, Universidad de Chile, Chile.
authors.forename: Michel
authors.initials: M
authors.lastname: Naser
authors.affiliation: Pelvic Floor Unit, Obstetrics and Gynecology Department, Clinical Hospital, Universidad de Chile, Chile.
authors.forename: Amalia
authors.initials: A
authors.lastname: Aguilera
authors.affiliation: Pelvic Floor Unit, Obstetrics and Gynecology Department, Clinical Hospital, Universidad de Chile, Chile.
authors.forename: Simonie
authors.initials: S
authors.lastname: Narvaez
authors.affiliation: Clinical Investigation Support Department, Clinical Hospital, Universidad de Chile, Chile.
authors.forename: Ariel
authors.initials: A
authors.lastname: Castro
authors.affiliation: Division of Urogynecology & Incontinence, Medical University of South Carolina, United States.
authors.forename: Steven
authors.initials: S
authors.lastname: Swift
authors.affiliation: Imperial College Healthcare NHS Trust, Academic Department of Obstetrics & Gynaecology, United Kingdom.
authors.forename: G Alessandro
authors.initials: GA
authors.lastname: Digesu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004599:Electric Stimulation Therapy; D005260:Female; D006801:Humans; D008333:Mandelic Acids / Q000627:therapeutic use*; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D013979:Tibial Nerve / Q000503:physiopathology*; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D064804:Urological Agents / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D008333:Mandelic Acids; D064804:Urological Agents; C005419:oxybutynin
keywords: Neuromodulation; Overactive bladder; Quality of life