title: Thyroid-like Follicular Carcinoma of the Kidney and Papillary Renal Cell Carcinoma with Thyroid-like Feature: Comparison of Two Cases and Literature Review.
abstract: Thyroid-like follicular carcinoma of the kidney (TLFCK) is a provisional new entity of renal cell carcinoma (RCC). We herein reported and compared one TLFCK case and one PRCC case with thyroid-like feature. The former entirely consisted of thyroid-like follicular architecture and the tumor cells were diffusely positive for PAX-8, but negative for CK7, AMACR, and CD10. By contrast, both papillary architecture (~60%) and thyroid-like follicular architecture (~40%) were identified in the latter. Tumor cells in both histological components exhibited diffusely positive staining for PAX-8, CK7, AMACR, but negative for CD10. FISH analysis showed no aberration in TLFCK case but trisomy of chromosome 17 in PRCC case. Along with a brief literature review, we presented that recognition of TLFCK is important to distinguish it from other conditions that show thyroid-like features. Additionally, a diagnosis of TLFCK should be cautiously made when papillary component is present in the tumor.
authors.affiliation: Department of Pathology, Shandong University Qilu Hospital, Jinan, P. R. China Department of Pathology, Shandong University Medical School, Jinan, P. R. China.
authors.forename: Congcong
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Pathology, Shandong University Qilu Hospital, Jinan, P. R. China Department of Pathology, Linyi People's Hospital, Linyi, P. R. China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Dong
authors.affiliation: Department of Pathology, Shandong University Qilu Hospital, Jinan, P. R. China Department of Pathology, The Affiliated Hospital of Qingdao University Medical College, Qingdao, P. R. China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Fu
authors.affiliation: Department of Pathology, Shandong University Qilu Hospital, Jinan, P. R. China.
authors.forename: Mei
authors.initials: M
authors.lastname: Qi
authors.affiliation: Department of Pathology, Shandong University Qilu Hospital, Jinan, P. R. China Department of Pathology, Shandong University Medical School, Jinan, P. R. China boh@sdu.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Han
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002886:Chromosomes, Human, Pair 17; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009030:Mosaicism; D015260:Neprilysin / Q000378:metabolism; D000072636:PAX8 Transcription Factor; D051761:Paired Box Transcription Factors / Q000378:metabolism; D019998:Racemases and Epimerases / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology; D014314:Trisomy
chemical_list: D000072636:PAX8 Transcription Factor; C083325:PAX8 protein, human; D051761:Paired Box Transcription Factors; D015260:Neprilysin; D019998:Racemases and Epimerases; C108352:alpha-methylacyl-CoA racemase
keywords: Thyroid-like follicular carcinoma of the kidney; differential diagnosis; papillary renal cell carcinoma