title: Non-Islet Cell Tumor Hypoglycemia Is Caused by Big IGF-II in a Patient with a Carcinosarcoma of the Uterus.
abstract: We report a 72-year-old Japanese woman with severe hypoglycemia. The laboratory data, which revealed the suppression of serum insulin, suggested the existence of non-islet cell tumor hypoglycemia (NICTH). Abdominal computed tomography demonstrated the presence of a huge uterine tumor. The patient was treated with a continuous infusion of glucose, but died of sepsis on day 46. An autopsy revealed the pathological diagnosis to be a carcinosarcoma of the uterus. Interestingly, an immunohistochemical study discovered the expression of insulin-like growth factor (IGF)-II in both the carcinoma and sarcoma cells. In addition, an immunoblot analysis of blood samples revealed the presence of circulating big IGF-II. Therefore, this is a novel case of NICTH that was caused by a uterine carcinosarcoma.
authors.affiliation: Division of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Honma
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Mizue
authors.initials: M
authors.lastname: Matsui
authors.forename: Takashi
authors.initials: T
authors.lastname: Satoh
authors.forename: Izumi
authors.initials: I
authors.lastname: Fukuda
authors.forename: Kazuma
authors.initials: K
authors.lastname: Takahashi
authors.forename: Noriko
authors.initials: N
authors.lastname: Takebe
authors.forename: Kan
authors.initials: K
authors.lastname: Nagasawa
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Ono
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Sasai
authors.forename: Takashi
authors.initials: T
authors.lastname: Kajiwara
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Sugai
authors.forename: Jo
authors.initials: J
authors.lastname: Satoh
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ishigaki
mesh_terms: D000368:Aged; D002296:Carcinosarcoma / Q000175:diagnosis / Q000503:physiopathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007335:Insulin-Like Growth Factor II / Q000096:biosynthesis*; D014057:Tomography, X-Ray Computed / Q000009:adverse effects; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000503:physiopathology*
chemical_list: C035170:IGF2 protein, human; D007335:Insulin-Like Growth Factor II