title: Fluorescence-Enhanced Sensing of Hypochlorous Acid Based on 2-Pyridylthiazole Unit.
abstract: Hypochlorous acid, being one of reactive oxygen species (ROS), is essential to protect the body against invasion of pathogens. Excess of hypochlorous acid (HOCl) is believed to be in tight connection with various inflammation-related diseases. It remains a challenge to detect the ROS in physiological conditions (aqueous buffer and neutral pH) with selectivity. In the presented paper, we have synthesized a ferrocence-modified pyridylthiazole derivatives, 1,4-di{5-[(4'-ferrocenyl-2'-(4"-pyridyl)]thiazinyl}benzene (DFPT). Only HOCl could turn-on the fluorescence of DFPT with enhanced emission at 465 nm. Compared to the other reported HOCl sensors, DFPT could selectively detect HOCl with rapid response (< 60 s) in the aqueous buffer (pH = 7.0). The detection limit at pH = 7.0 was 0.7 μM according to the titration experiment.
authors.affiliation: Department of Chemistry, Yanbian University, Yanji city, Jilin Province, 133002, China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Zheng
authors.affiliation: Department of Chemistry, Yanbian University, Yanji city, Jilin Province, 133002, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Chemistry, Yanbian University, Yanji city, Jilin Province, 133002, China.
authors.forename: Xiu-Wen
authors.initials: XW
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Yanbian University, Yanji city, Jilin Province, 133002, China.
authors.forename: Xi-Ling
authors.initials: XL
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Yanbian University, Yanji city, Jilin Province, 133002, China. jyjin-chem@ybu.edu.cn.
authors.forename: Jing-Yi
authors.initials: JY
authors.lastname: Jin
keywords: 2-pyridylthiazole; Ferrocene; Fluorescence; Hypochlorous acid; Sensor