title: Quantitation of Total Buprenorphine and Norbuprenorphine in Meconium by LC-MS/MS.
abstract: Buprenorphine (Suboxone, Zubsolv, Buprenex, Butrans, etc.) is an opioid drug that has been used to treat opioid dependence on an outpatient basis, and is also prescribed for managing moderate to severe pain. Pregnant women may be prescribed buprenorphine as part of a treatment plan for opioid addiction. This chapter quantitates buprenorphine and norbuprenorphine in meconium by liquid chromatography tandem mass spectrometry (LC-MS/MS).
authors.affiliation: ARUP Institute for Clinical and Experimental Pathology, 500 Chipeta Way, Salt Lake City, UT, 84108, USA. stephanie.marin@aruplab.com.
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Marin
authors.affiliation: ARUP Laboratories, Salt Lake City, UT, USA.|Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
authors.forename: Gwendolyn A
authors.initials: GA
authors.lastname: McMillin
mesh_terms: D000701:Analgesics, Opioid / Q000032:analysis*; D002047:Buprenorphine / Q000031:analogs & derivatives* / Q000032:analysis*; D002853:Chromatography, Liquid / Q000379:methods*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008470:Meconium / Q000737:chemistry*; D009293:Opioid-Related Disorders / Q000188:drug therapy; D011247:Pregnancy; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine; C043585:norbuprenorphine
keywords: Buprenorphine; LC-MS/MS; Meconium; NAS; Neonatal abstinence syndrome; Neonate; Pregnancy