title: Citrus medica L. cv Diamante (Rutaceae) peel extract improves glycaemic status of Zucker diabetic fatty (ZDF) rats and protects against oxidative stress.
abstract: This study aimed to investigate the antidiabetic, antilipidaemic and antioxidant activities of Citrus medica cv Diamante (Rutaceae) hydroalcoholic (CD) peel extract in Zucker diabetic fatty (ZDF) rats. The ability of CD to protect against oxidative stress was investigated by using different in vitro assays and in vivo by using the reactive oxygen metabolites-derived compounds (d-ROMs) test and the biological antioxidant potential test (BAP). Two different doses of CD extract (300 and 600 mg/kg/die) were administered at ZDF rats for 4 weeks. CD reduced cholesterol and triglycerides levels. A dose-dependent effect on body weight and serum glucose levels was observed. A decrease of d-ROMs and an increase of BAP were recorded by using the dose of 600 mg/kg. The extract inhibited lipid peroxidation (IC50 value of 0.23 mg/ml). These findings suggest as an efficient phytotherapeutic approach in combating hyperlipidaemic and hyperglycaemic disorders.
authors.affiliation: a Department of Pharmacy , Health and Nutritional Sciences, University of Calabria , Rende , Italy and.
authors.forename: Francesco
authors.initials: F
authors.lastname: Menichini
authors.affiliation: a Department of Pharmacy , Health and Nutritional Sciences, University of Calabria , Rende , Italy and.
authors.forename: Rosa
authors.initials: R
authors.lastname: Tundis
authors.affiliation: a Department of Pharmacy , Health and Nutritional Sciences, University of Calabria , Rende , Italy and.
authors.forename: Monica R
authors.initials: MR
authors.lastname: Loizzo
authors.affiliation: a Department of Pharmacy , Health and Nutritional Sciences, University of Calabria , Rende , Italy and.
authors.forename: Marco
authors.initials: M
authors.lastname: Bonesi
authors.affiliation: b Department of Veterinary Medicine and Animal Production , University of Naples Federico II , Naples , Italy.
authors.forename: Danila
authors.initials: D
authors.lastname: D'Angelo
authors.affiliation: b Department of Veterinary Medicine and Animal Production , University of Naples Federico II , Naples , Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Lombardi
authors.affiliation: b Department of Veterinary Medicine and Animal Production , University of Naples Federico II , Naples , Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Mastellone
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002957:Citrus / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D011924:Rats, Zucker
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts
keywords: Antioxidant effects; Citrus medica L. cv Diamante; hypoglycaemic; hypolipidaemic; in vivo studies