title: Total synthesis of panicein A2.
abstract: The first total synthesis of the unusual aromatic sesquiterpene panicein A2 is reported and the structure of the natural product has been confirmed. When tested by the NCI against a range of human cancer cell lines, it was found that panicein A2 exhibits very little antiproliferative activity at 10 μM - an observation that is at odds with the earlier report that stated panicein A2 exhibits in vitro cytotoxicity against a number of tumour cell lines.
authors.affiliation: School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland, New Zealand.
authors.forename: Lili
authors.initials: L
authors.lastname: Yeung
authors.affiliation: School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland, New Zealand.
authors.forename: Lisa I
authors.initials: LI
authors.lastname: Pilkington
authors.affiliation: School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland, New Zealand.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Cadelis
authors.affiliation: School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland, New Zealand.
authors.forename: Brent R
authors.initials: BR
authors.lastname: Copp
authors.affiliation: School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland, New Zealand.
authors.forename: David
authors.initials: D
authors.lastname: Barker
keywords: chromenol; modified Claisen rearrangement; sesquiterpene; total synthesis