title: [MOLECULAR PATHOLOGY OF MENINGIOMAS].
abstract: Meningiomas represent nearly one-third of all adult primary brain tumours. According to their clinical and histologic appearance, they can be divided into WHO grades I-III. Almost 90% of meningiomas are benign, showing favourable response to conventional therapies, however, patients diagnosed with grade 2 and 3 tumours may have a poor prognosis. In addition, high frequency of tumour recurrence renders treatments more challenging even in benign meningiomas. Molecular-pathological profiling of meningiomas could lead to development of more effective therapies. Although the cytogenetic background of these tumours are already well-characterised, the majority of related genes and mutations is still unknown. Recently, high-throughput techniques enabled better characterisation of mechanisms involved in meningioma development, progression and recurrence. Furthermore, epigenetic dysregulation could offer new opportunities for both diagnosis and treatment of meningiomas. We provide a comprehensive overview of cytogenetic and molecular genetic defects as well as epigenetic alterations in meningiomas. Many of these may serve as biomarker or therapeutic target in the near future.
authors.forename: Balazs
authors.initials: B
authors.lastname: Murnyák
authors.forename: Tamás
authors.initials: T
authors.lastname: Csonka
authors.forename: Tibor
authors.initials: T
authors.lastname: Hortobágyi
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology; D018899:CpG Islands / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D052138:Genes, Neoplasm / Q000235:genetics*; D006801:Humans; D019656:Loss of Heterozygosity; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D008579:Meningioma / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics; D009154:Mutation; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000473:pathology; D057089:Pathology, Molecular; D011379:Prognosis; D012307:Risk Factors
chemical_list: D035683:MicroRNAs