title: Myocardial injury associated with transcatheter aortic valve implantation (TAVI).
abstract: Transcatheter aortic valve implantation (TAVI) has emerged as an important treatment option for elderly patients with symptomatic aortic stenosis whose risk is too high or prohibitive for conventional surgery. Despite notable progress during the past decade, continuous efforts directed at further improvement of procedural safety and performance are required, especially considering expanding indications for interventional treatment options among lower-risk populations. One issue that needs to be addressed is myocardial damage, which can frequently be observed after TAVI and has been linked to worse prognosis. Yet, knowledge concerning the underlying mechanisms and clinical impact remains scarce, and further investigation in this field is warranted. In this review, we provide a contemporary summary of the types of myocardial injury associated with TAVI, including access-related injury, mechanical trauma and ischemia, the role of myocardial biomarkers, and the impact on left ventricular function, with emphasis on potential mechanisms and clinical implications.
authors.affiliation: Department of Cardiology, Kerckhoff Heart and Thorax Center, 61231, Bad Nauheim, Germany.|Department of Cardiac Surgery, Kerckhoff Heart and Thorax Center, 61231, Bad Nauheim, Germany.
authors.forename: Won-Keun
authors.initials: WK
authors.lastname: Kim
authors.affiliation: Department of Cardiology, Kerckhoff Heart and Thorax Center, 61231, Bad Nauheim, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Liebetrau
authors.affiliation: Department of Cardiac Surgery, Kerckhoff Heart and Thorax Center, 61231, Bad Nauheim, Germany.
authors.forename: Arnaud
authors.initials: A
authors.lastname: van Linden
authors.affiliation: Department of Cardiology, Kerckhoff Heart and Thorax Center, 61231, Bad Nauheim, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Blumenstein
authors.affiliation: Department of Cardiology, Kerckhoff Heart and Thorax Center, 61231, Bad Nauheim, Germany.
authors.forename: Luise
authors.initials: L
authors.lastname: Gaede
authors.affiliation: Department of Cardiology, Kerckhoff Heart and Thorax Center, 61231, Bad Nauheim, Germany.|Department of Cardiology, University of Giessen, Giessen, Germany.
authors.forename: Christian W
authors.initials: CW
authors.lastname: Hamm
authors.affiliation: Department of Cardiac Surgery, Kerckhoff Heart and Thorax Center, 61231, Bad Nauheim, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Walther
authors.affiliation: Department of Cardiology, Kerckhoff Heart and Thorax Center, 61231, Bad Nauheim, Germany. h.moellmann@kerckhoff-klinik.de.
authors.forename: Helge
authors.initials: H
authors.lastname: Möllmann
mesh_terms: D000818:Animals; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000628:therapy*; D015415:Biomarkers / Q000378:metabolism; D006328:Cardiac Catheterization / Q000009:adverse effects* / Q000379:methods; D017023:Coronary Angiography; D018618:Echocardiography, Doppler, Color; D006335:Heart Injuries / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D011237:Predictive Value of Tests; D012307:Risk Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers
keywords: Aortic valve; Myocardial biomarker; Myocardial injury; TAVI