title: Evaluation of peripheral blood CD34+ cell count in the acute phase of traumatic brain injury and chest trauma.
abstract: OBJECTIVE
  To determine the impact of traumatic brain injury (TBI) and chest trauma (CT) on the number of peripheral blood (PB) stem cells in affected patients in comparison to normal controls. Additionally, the aim was to determine the relationship between CD34+ cell counts and TBI-induced hypothalamus-pituitary-adrenal axis dysfunction in the acute phase of trauma.
  
  
  METHODS
  Thirty patients with TBI, 12 patients with CT and 53 healthy subjects were included in the study.
  
  
  RESULTS
  CD34+ cell counts within the first 24-48 hours of TBI were found to be lower than those obtained on the 7(th) day of TBI and those in the healthy controls. CD34+ cell counts obtained on the 2(nd) day of CT were lower than those in the healthy group, but did not differ from those measured on the 7(th) day of CT. There was no correlation between CD34+ cell counts and serum total cortisol (STC) levels on the 2(nd) and 7(th) days in the TBI or CT groups.
  
  
  CONCLUSIONS
  An increase in CD34+ cell counts as observed on the 7(th) day in both TBI and CT groups suggested that CD34 changes were not specific to TBI. Moreover, this study showed for the first time that CD34 response was not affected by changes in cortisol levels induced by TBI and severity of TBI.
authors.affiliation: a Department of Endocrinology and Metabolism , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Gulsah
authors.initials: G
authors.lastname: Elbuken
authors.affiliation: a Department of Endocrinology and Metabolism , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Tanriverdi
authors.affiliation: a Department of Endocrinology and Metabolism , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Zuleyha
authors.initials: Z
authors.lastname: Karaca
authors.affiliation: b Department of Hematology , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Eser
authors.affiliation: c Department of Chest Surgery , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Leyla
authors.initials: L
authors.lastname: Hasdiraz
authors.affiliation: a Department of Endocrinology and Metabolism , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Kursad
authors.initials: K
authors.lastname: Unluhizarci
authors.affiliation: d Department of Neurosurgery , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Abdulkerim
authors.initials: A
authors.lastname: Gokoglu
authors.affiliation: e Department of Biochemistry , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Aysun
authors.initials: A
authors.lastname: Cetin
authors.affiliation: d Department of Neurosurgery , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Selcuklu
authors.affiliation: a Department of Endocrinology and Metabolism , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Fahrettin
authors.initials: F
authors.lastname: Kelestimur
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis* / Q000097:blood; D000070642:Brain Injuries, Traumatic / Q000401:mortality / Q000503:physiopathology*; D016022:Case-Control Studies; D002452:Cell Count; D005260:Female; D005544:Forecasting; D006801:Humans; D008297:Male; D008875:Middle Aged; D013898:Thoracic Injuries / Q000401:mortality / Q000503:physiopathology*
chemical_list: D018952:Antigens, CD34
keywords: CD 34; Hematopoeitic stem cell; chest trauma; cortisol; healthy group; traumatic brain injury