title: Mean Platelet Volume as a Surrogate Marker for Platelet Activation in Patients With Idiopathic Pulmonary Fibrosis.
abstract: BACKGROUND
  Idiopathic pulmonary fibrosis (IPF) is associated with a prothrombotic state.
  
  
  OBJECTIVE
  To study mean platelet volume (MPV) and Platelet Distribution Width (PDW) as markers of platelet activation and their potential association with lung function in patients with recently diagnosed IPF.
  
  
  METHODS
  This study included 56 patients with IPF (age 64.9±7.4 years) and 79 controls (age 64.2 ± 5.9 years).
  
  
  RESULTS
  An inverse relation was demonstrated between platelet count and MPV in the control group but not among patients with IPF. Platelet count was significantly lower in patients with IPF compared with controls (230 ± 60 vs 256 ± 75 × 10(3)/μL, P = .038). Conversely, MPV was higher in patients versus controls (10.3 ± 1.2 vs 9.8 ± 1.2 fl, P = .024), while there was no difference between the groups in PDW. Respiratory function was, as expected, significantly impaired in patients with IPF versus controls in terms of forced expiratory volume in first second (FEV1; 67.2 ± 23.1 vs 102.6 ± 15.9% of predicted value, P < .001), forced vital capacity (FVC; 65.3 ± 21 vs 95.2 ± 16.1% of predicted value, P < .001), FEV1/FVC (83.1 ± 15 vs 87.5 ± 6.4%, P = .041) and partial pressure of oxygen in arterial blood (PaO2; 67.1 ± 10.3 vs 81.5 ± 15.2 mm Hg, P < .001). No significant correlation was seen between MPV and FVC (r = -.1497, P = .275), MPV and lung diffusion capacity for carbon monoxide (r = .035, P = .798) and total lung capacity (r = .032, P = .820).
  
  
  CONCLUSIONS
  Patients with IPF exhibit higher MPV values and lower platelet count. Further studies are needed to assess the clinical implications of these findings.
authors.affiliation: Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Ntolios
authors.affiliation: Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece papanasnikos@yahoo.gr.
authors.forename: N
authors.initials: N
authors.lastname: Papanas
authors.affiliation: Laboratory of Hygiene and Environmental Protection, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Nena
authors.affiliation: Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Boglou
authors.affiliation: Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Koulelidis
authors.affiliation: Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Tzouvelekis
authors.affiliation: Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Xanthoudaki
authors.affiliation: Hematology Laboratory, University Hospital of Alexandroupolis, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Tsigalou
authors.affiliation: Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: M E
authors.initials: ME
authors.lastname: Froudarakis
authors.affiliation: Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Bouros
authors.affiliation: Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), Royal Free Hospital campus, University College London Medical School, University College London, London, United Kingdom.
authors.forename: D P
authors.initials: DP
authors.lastname: Mikhailidis
authors.affiliation: Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Steiropoulos
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000097:blood*; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015539:Platelet Activation
chemical_list: D015415:Biomarkers
keywords: idiopathic pulmonary fibrosis; mean platelet volume; platelet distribution width; platelets