title: Advances in cryopreservation of spermatogonial stem cells and restoration of male fertility.
abstract: Spermatogenesis is a highly complicated process which initiated by spermatogonial stem cells (SSCs). SSCs are the only cell type that can restore fertility in infertile recipient after SSCs transplantation. SSCs damage during cancer diagnosis and therapy and their depletion may be cause of male infertility in cancer survivors. In this review, used experimental methods regarding SSCs and testis tissue cryopreservation have been reviewed with a special focus on animal models and human which have generated the majority of data about SSCs and the cryopreservation process.
authors.affiliation: Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Fereshte
authors.initials: F
authors.lastname: Aliakbari
authors.affiliation: Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hosein
authors.initials: H
authors.lastname: Yazdekhasti
authors.affiliation: Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Abbasi
authors.affiliation: Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mahdieh
authors.initials: M
authors.lastname: Hajian Monfared
authors.affiliation: Department of Anatomy, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Baazm
mesh_terms: D000818:Animals; D015925:Cryopreservation / Q000379:methods / Q000639:trends*; D006801:Humans; D007248:Infertility, Male / Q000628:therapy*; D008297:Male; D013093:Spermatogonia / Q000737:chemistry* / Q000166:cytology; D013234:Stem Cells / Q000737:chemistry* / Q000166:cytology
keywords: cancer; cryopreservation; cryoprotectants; spermatogonial stem cells; testis tissue