title: [Determination of normal reference value of pyrrole adducts in urine in young people in a university in Shandong, China].
abstract: OBJECTIVE
  To determine the normal reference value of pyrrole adducts in urine in young people in a university in Shandong, China, and to provide a reliable basis for the clinical diagnosis of n-hexane poisoning.
  
  
  METHODS
  A total of 240 college students were randomly selected. After excluding 32 ineligible students, 208 subjects were included in this study, consisting of 104 males and 104 females, with a mean age of 21?3 years (range: 18 to 24 years). Morning urine was collected from each subject. The content of pyrrole adducts was determined by chromatometry.
  
  
  RESULTS
  The content of pyrrole adducts in both male and female obeyed a positively skewed distribution. The median level of pyrrole adducts in male subjects was 0.88 nmol/ml, and the reference value was 0.14-3.92 nmol/ml. The median level of pyrrole adducts in female subjects was 0.93 nmol/ ml, and the reference value was 0.09-3.27 nmol/ml. Student's t test identified no statistical difference in pyrrole adduct level between male and female subjects (t=0.15, P>0.05).
  
  
  CONCLUSIONS
  The median level of pyrrole adducts in normal young people is 0.91 nmol/ml, and the reference value is 0.11-3.95 nmol/ml.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Yiping
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhenwei
authors.initials: Z
authors.lastname: Zhou
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
authors.forename: Hongyin
authors.initials: H
authors.lastname: Yin
authors.forename: Keqin
authors.initials: K
authors.lastname: Xie
mesh_terms: D000293:Adolescent; D002681:China; D005260:Female; D006586:Hexanes / Q000506:poisoning; D006801:Humans; D008297:Male; D011758:Pyrroles / Q000652:urine*; D012016:Reference Values; D014495:Universities; D055815:Young Adult
chemical_list: D006586:Hexanes; D011758:Pyrroles; C026385:n-hexane