title: Prevalence and characteristics of migraine in CADASIL.
abstract: Background and objective Migraine with aura (MA) is a major symptom of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). We assessed the spectrum of migraine symptoms and their potential correlates in a large prospective cohort of CADASIL individuals. Methods A standardized questionnaire was used in 378 CADASIL patients for assessing headache symptoms, trigger factors, age at first attack, frequency of attacks and associated symptoms. MRI lesions and brain atrophy were quantified. Results A total of 54.5% of individuals had a history of migraine, mostly MA in 84% of them; 62.4% of individuals with MA were women and age at onset of MA was lower in women than in men. Atypical aura symptoms were experienced by 59.3% of individuals with MA, and for 19.7% of patients with MA the aura was never accompanied by headache. MA was the inaugural manifestation in 41% of symptomatic patients and an isolated symptom in 12.1% of individuals. Slightly higher MMSE and MDRS scores and lower Rankin score were detected in the MA group. Conclusion MA is observed in almost half of all CADASIL patients. Atypical aura symptoms are reported by more than one in two of them. MA is often inaugural, can remain isolated and is not associated with the severity of the disorder.
authors.affiliation: 1 Department of Neurology, GH Saint-Louis-Lariboisière, Assistance Publique des Hôpitaux de Paris APHP, Université Paris Denis Diderot and DHU NeuroVasc Sorbonne Paris-Cité, France.|2 INSERM, UMR 1161, France.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Guey
authors.affiliation: 1 Department of Neurology, GH Saint-Louis-Lariboisière, Assistance Publique des Hôpitaux de Paris APHP, Université Paris Denis Diderot and DHU NeuroVasc Sorbonne Paris-Cité, France.|3 Emergency Headache Center, GH Saint-Louis-Lariboisière, Assistance Publique des Hôpitaux de Paris APHP, Université Paris Denis Diderot and DHU NeuroVasc Sorbonne Paris-Cité, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Mawet
authors.affiliation: 1 Department of Neurology, GH Saint-Louis-Lariboisière, Assistance Publique des Hôpitaux de Paris APHP, Université Paris Denis Diderot and DHU NeuroVasc Sorbonne Paris-Cité, France.|2 INSERM, UMR 1161, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Hervé
authors.affiliation: 4 Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University, Germany.
authors.forename: Marco
authors.initials: M
authors.lastname: Duering
authors.affiliation: 1 Department of Neurology, GH Saint-Louis-Lariboisière, Assistance Publique des Hôpitaux de Paris APHP, Université Paris Denis Diderot and DHU NeuroVasc Sorbonne Paris-Cité, France.
authors.forename: Ophelia
authors.initials: O
authors.lastname: Godin
authors.affiliation: 1 Department of Neurology, GH Saint-Louis-Lariboisière, Assistance Publique des Hôpitaux de Paris APHP, Université Paris Denis Diderot and DHU NeuroVasc Sorbonne Paris-Cité, France.|2 INSERM, UMR 1161, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Jouvent
authors.affiliation: 5 Department of Neurology, SLK-Kliniken, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Opherk
authors.affiliation: 1 Department of Neurology, GH Saint-Louis-Lariboisière, Assistance Publique des Hôpitaux de Paris APHP, Université Paris Denis Diderot and DHU NeuroVasc Sorbonne Paris-Cité, France.
authors.forename: Nassira
authors.initials: N
authors.lastname: Alili
authors.affiliation: 4 Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University, Germany.|6 Munich Cluster for Systems Neurology (SyNergy), Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Dichgans
authors.affiliation: 1 Department of Neurology, GH Saint-Louis-Lariboisière, Assistance Publique des Hôpitaux de Paris APHP, Université Paris Denis Diderot and DHU NeuroVasc Sorbonne Paris-Cité, France.|2 INSERM, UMR 1161, France.
authors.forename: Hugues
authors.initials: H
authors.lastname: Chabriat
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D046589:CADASIL / Q000175:diagnosis* / Q000453:epidemiology*; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005602:France / Q000453:epidemiology; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000175:diagnosis* / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D017678:Sex Distribution
keywords: CADASIL; aura; cortical spreading depression; migraine; small vessel disease