title: Soluble molecules in intravenous immunoglobulin: benefits and limitations.
abstract: Because of its predominance, the main immunomodulatory function of IVIg is carried out by the IgG molecules; while, based on multiple studies, the immunomodulatory role of other soluble molecules in commercial IVIg products is impossible to ignore. Although the existence of these molecules and their suppressive effects on the immune response may be considered a positive contribution to the treatment of autoimmune disorders, their presence, half-life, accumulation and immunosuppressive actions in immunocompromised patients should be monitored by physicians and manufacturing companies.
authors.affiliation: a Department of Immunology, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Azimi
authors.affiliation: b Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Asghar
authors.initials: A
authors.lastname: Aghamohammadi
authors.affiliation: c Department of Pediatrics , University of Washington and Seattle Children's Hospital Research Institute , Seattle , WA , USA.
authors.forename: Hans D
authors.initials: HD
authors.lastname: Ochs
authors.affiliation: a Department of Immunology, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.|b Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.|d Universal Scientific Education and Research Network (USERN) , Tehran , Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
mesh_terms: D001327:Autoimmune Diseases / Q000188:drug therapy*; D004340:Drug Contamination / Q000517:prevention & control; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000737:chemistry / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000737:chemistry / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D007166:Immunosuppressive Agents
keywords: Intravenous immunoglobulin; efficacy; immunomodulatory; sCD; sCD8; sFasL; sHLA molecules