title: [Antagonistic effect of curcumin on lipid peroxidation of rats poisoned by paraquat].
abstract: OBJECTIVE
  To explore the pathogenesis of paraquat poisoning and observe the change in lipid peroxidation of rats treated with different doses of curcumin.
  
  
  METHODS
  A total of 50 8-week-old male Wistar rats (clean grade) were randomly divided into high-dose curcumin plus conventional treatment group, low-dose curcumin plus conventional treatment group, high-dose curcumin treatment group, poisoned group, and blank control group. Glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) levels in rat serum were measured at 1, 3, 7, 14, and 21 d post paraquat injection.
  
  
  RESULTS
  Compared with the blank control group, other groups had significantly higher MDA levels but lower SOD, GSH-PX, and CAT activities. The high-dose, low-dose curcumin plus conventional treatment, and high-dose curcumin treatment groups had significantly lower serum lipid peroxidation levels compared with the poisoned group and among them the high-dose curcumin plus conventional treatment group had the most significant improvement.
  
  
  CONCLUSIONS
  Curcumin can significantly decrease serum lipid peroxidation level in rats and inhibit and delay the occurrence and progression of the damage to the body.
authors.affiliation: Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Li
authors.affiliation: E-mail: 187179946@qq.com.
authors.forename: Yongzhi
authors.initials: Y
authors.lastname: Cao
authors.forename: Baonan
authors.initials: B
authors.lastname: Liu
authors.forename: Lingji
authors.initials: L
authors.lastname: Feng
authors.forename: Peng
authors.initials: P
authors.lastname: Li
mesh_terms: D000818:Animals; D002374:Catalase / Q000097:blood; D003474:Curcumin / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010269:Paraquat / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D003474:Curcumin; D010269:Paraquat