title: Trends in incidence of oesophageal and gastric cancer according to morphology and anatomical location, in Switzerland 1982-2011.
abstract: This study aimed to evaluate trends in the incidence of oesophageal and gastric cancer by anatomical location and histology using nationally representative Swiss data.
  
  
  METHODS
  We included all oesophageal and gastric cancers recorded in 10 Swiss population-based cancer registries 1982-2011. We calculated age-standardised incidence rates (ASIRs) per 100 000 person-years (PY) (European standard) for both cancer sites stratified by sex, language region (German, French-Italian), morphology and anatomical location. To assess time trends, we estimated annual percentage changes (APCs) with 95% confidence intervals (95% CIs).
  
  
  RESULTS
  ASIR of oesophageal adenocarcinoma increased in both sexes and language regions (p <0.001). The steepest increase occurred in males of the German-speaking region (APC 6.8%, 95% CI 5.8-7.8) with ASIRs of 0.8 per 100,000 PY in 1982-1987 and 3.9 per 100.000 PY in 2007-2011. Incidence of oesophageal squamous cell carcinoma decreased significantly in males of both language regions by around -1.5% per year. In contrast, a slight but significant increase (APC 1.4%, 95% CI 0.3-2.4]) of oesophageal squamous cell carcinoma was observed in females of the German-speaking region. We observed stable rates for cancer of the gastric cardia. The incidence of noncardia gastric cancer decreased substantially in both sexes and language regions (p <0.001).
  
  
  CONCLUSIONS
  In Switzerland, the incidence of oesophageal adenocarcinoma has risen whereas incidence of noncardia gastric cancer has decreased substantially as observed in other developed countries.
authors.affiliation: National Institute for Cancer Epidemiology and Registration (NICER), Zürich, Switzerland; Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland.
authors.forename: Anita
authors.initials: A
authors.lastname: Feller
authors.affiliation: Kantonsspital St. Gallen, Department Oncology and Haematology, St. Gallen, Switzerland.
authors.forename: Martin
authors.initials: M
authors.lastname: Fehr
authors.affiliation: Ticino Cancer Registry, Institute of Pathology, Locarno, Switzerland.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bordoni
authors.affiliation: Geneva Cancer Registry, Institute of Global Health, University of Geneva, Switzerland.
authors.forename: Christine
authors.initials: C
authors.lastname: Bouchardy
authors.affiliation: Cancer Registry St Gallen-Appenzell, Cancer League St. Gallen-Appenzell, St. Gallen, Switzerland.
authors.forename: Harald
authors.initials: H
authors.lastname: Frick
authors.affiliation: Cancer Registry of Basel-Stadt and Basel-Landschaft, Gesundheitsdepartement des Kantons Basel-Stadt, Bereich Gesundheitsdienste, Abteilung Projekte und Services, Basel, Switzerland.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Mousavi
authors.affiliation: SAKK Coordinating Centre, Bern, Switzerland.
authors.forename: Annik
authors.initials: A
authors.lastname: Steiner
authors.affiliation: National Institute for Cancer Epidemiology and Registration (NICER), Zürich, Switzerland.
authors.forename: Volker
authors.initials: V
authors.lastname: Arndt
authors.affiliation: Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland.
authors.forename: Kerri M
authors.initials: KM
authors.lastname: Clough-Gorr
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology*; D004938:Esophageal Neoplasms / Q000453:epidemiology*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D006801:Humans; D015994:Incidence; D007802:Language; D008297:Male; D008875:Middle Aged; D012042:Registries; D017678:Sex Distribution; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D013557:Switzerland / Q000453:epidemiology; D055815:Young Adult