title: Dichotomous effects of latent CMV infection on the phenotype and functional properties of CD8+ T-cells and NK-cells.
abstract: CMV markedly alters the phenotype and function of NK-cells and T-cells and has been linked to immunosenescence. We show here that subjects with effective CMV control (evidenced by low CMV IgG titers) have functional responses to CMV that are driven by either NKG2C+ NK-cells or CMV-specific T-cells (15 of 24 subjects), but not both. These data indicate that people with effective CMV control are either NK-cell or T-cell responders, and corroborates the idea that NK-cells have rheostat-like properties that regulate anti-viral T-cell responses. Whether or not lifelong CMV control through either NK-cell or T-cell responses have implications for immunosenescence remains to be determined.
authors.affiliation: Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX 77204, USA.
authors.forename: Austin B
authors.initials: AB
authors.lastname: Bigley
authors.affiliation: Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX 77204, USA; School of Kinesiology, Louisiana State University, 112 Long Fieldhouse, Baton Rouge, LA 70803, USA.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Spielmann
authors.affiliation: Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX 77204, USA.
authors.forename: Nadia
authors.initials: N
authors.lastname: Agha
authors.affiliation: Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX 77204, USA.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: O'Connor
authors.affiliation: Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX 77204, USA. Electronic address: rjsimpson@uh.edu.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Simpson
mesh_terms: D000328:Adult; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D003587:Cytomegalovirus / Q000502:physiology; D003586:Cytomegalovirus Infections / Q000276:immunology*; D058501:Enzyme-Linked Immunospot Assay; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D000068884:Immunosenescence / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D010641:Phenotype; D017735:Virus Latency / Q000276:immunology*
keywords: Aging; CD27; CD28; CD57; Cytotoxicity; IE1; Immunosenescence; K562; NKCA; NKG2C; Viral load; pp65