title: A gateway to the brain: shuttles for brain delivery of macromolecules.
authors.affiliation: Antibody Discovery & Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK.
authors.forename: Carl I
authors.initials: CI
authors.lastname: Webster
authors.affiliation: Human Health Therapeutics Portfolio, National Research Council of Canada, Ottawa, ON K1A 0R6, Canada.
authors.forename: Danica B
authors.initials: DB
authors.lastname: Stanimirovic
mesh_terms: D001812:Blood-Brain Barrier / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances / Q000737:chemistry / Q000378:metabolism*; D057900:Transcytosis / Q000502:physiology
chemical_list: D004337:Drug Carriers; D046911:Macromolecular Substances
keywords: bispecific antibodies; blood–brain barrier; clinical translation; receptor-mediated transcytosis; safety and toxicology