title: An N-Heterocyclic Carbene-Catalyzed Oxidative γ-Aminoalkylation of Saturated Carboxylic Acids through in Situ Activation Strategy: Access to δ-Lactam.
abstract: An N-Heterocyclic Carbene (NHC)-catalyzed oxidative formal [4 + 2] annulation of acylhydrazones with saturated carboxylic acids bearing γ-H to assemble δ-lactams featuring a chiral carbon stereogenic center was developed through an in situ activation strategy. The ready availability of the starting materials, excellent enantioselectivity, facile assembly, high yields, and potential biological significance of the final products make this protocol an attractive alternative for the construction of the pyridinone scaffold.
authors.affiliation: Jangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou Jiangsu 221116, P. R. China.
authors.forename: Yonglei
authors.initials: Y
authors.lastname: Que
authors.affiliation: Jangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou Jiangsu 221116, P. R. China.
authors.forename: Yuanwei
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Jangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou Jiangsu 221116, P. R. China.
authors.forename: Tuanjie
authors.initials: T
authors.lastname: Li
authors.affiliation: Jangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou Jiangsu 221116, P. R. China.
authors.forename: Chenxia
authors.initials: C
authors.lastname: Yu
authors.affiliation: Jangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou Jiangsu 221116, P. R. China.
authors.forename: Shujiang
authors.initials: S
authors.lastname: Tu
authors.affiliation: Jangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou Jiangsu 221116, P. R. China.
authors.forename: Changsheng
authors.initials: C
authors.lastname: Yao
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D002264:Carboxylic Acids; D007769:Lactams; C030011:carbene; D008697:Methane