title: Eye movements in neurodegenerative diseases.
abstract: OBJECTIVE
  Abnormalities of oculomotor control accompany the pathological changes underlying many neurodegenerative diseases. Clinical examination of eye movements can contribute to differential diagnosis, whereas quantitative laboratory measures can provide detailed insight into the disease process. In this review of eye movements in neurodegenerative disease, we summarise recent empirical findings and conceptual advances.
  
  
  RESULTS
  Oculomotor researchers continue to be particularly prolific in studying Parkinson's disease but there is also substantial activity in Alzheimer's disease and spinocerebellar ataxia. Interesting findings have been reported in Huntington's, motor neuron disease, and glaucoma. Most studies report laboratory-based investigations but useful progress in clinical description continues to be made.
  
  
  CONCLUSIONS
  Eye movements remain an active field of investigation across a variety of neurodegenerative conditions. Progress continues to be made at the clinical level as well by using laboratory techniques.
authors.affiliation: aNew Zealand Brain Research Institute bDepartment of Medicine, University of Otago cDepartment of Neurology, Christchurch Hospital, Christchurch, New Zealand.
authors.forename: Michael R
authors.initials: MR
authors.lastname: MacAskill
authors.forename: Tim J
authors.initials: TJ
authors.lastname: Anderson
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D005133:Eye Movements / Q000502:physiology*; D006801:Humans; D016472:Motor Neuron Disease / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D019636:Neurodegenerative Diseases / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D012106:Research