title: Quinones and coumarins from Ajania salicifolia and their radical scavenging and cytotoxic activity.
abstract: 1,4-Naphthoquinone (1) and a new coumarin (3) were isolated from Ajania salicifolia, together with two known compounds (2, 4). The structures and stereochemistry of new compounds were elucidated using spectroscopic methods. Two compounds exhibited potent ABTS cation radical scavenging activities with IC50 values ranging 7.97-8.44 μM. Two quinones (1, 2) exhibited moderate cytotoxic activity against the human cancer cell lines (Hela, HepG2, and K562) with IC50 values of 11.24-35.15 μM in vitro. This is the first report of naphthoquinone in the genus Ajania.
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 , China.
authors.forename: Hong-Ru
authors.initials: HR
authors.lastname: Wu
authors.affiliation: b Department of Physiology, College of Basic Medicine , Lanzhou University , Lanzhou 730000 , China.|c Key Laboratory of Pre-clinical Study for New Drugs of Gansu province , Lanzhou University , Lanzhou 730000 , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 , China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Pang
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 , China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gong
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 , China.
authors.forename: Xian Muxinuer U
authors.initials: XM
authors.lastname: Obulqasim
authors.affiliation: b Department of Physiology, College of Basic Medicine , Lanzhou University , Lanzhou 730000 , China.|c Key Laboratory of Pre-clinical Study for New Drugs of Gansu province , Lanzhou University , Lanzhou 730000 , China.
authors.forename: Hong-Fang
authors.initials: HF
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D003374:Coumarins; D016166:Free Radical Scavengers; D009285:Naphthoquinones; D011809:Quinones; C035342:1,4-naphthoquinone
keywords: Ajania salicifolia; Asteraceae; coumarins; cytotoxicities; quinones; radical scavenging capacity