title: The feasibility of text reminders to improve medication adherence in adolescents with asthma.
abstract: Personal health applications have the potential to help patients with chronic disease by improving medication adherence, self-efficacy, and quality of life. The goal of this study was to assess the impact of MyMediHealth (MMH) - a website and a short messaging service (SMS)-based reminder system - on medication adherence and perceived self-efficacy in adolescents with asthma.
  
  
  
  We conducted a block-randomized controlled study in academic pediatric outpatient settings. There were 98 adolescents enrolled. Subjects who were randomized to use MMH were asked to create a medication schedule and receive SMS reminders at designated medication administration times for 3 weeks. Control subjects received action lists as a part of their usual care. Primary outcome measures included MMH usage patterns and self-reports of system usability, medication adherence, asthma control, self-efficacy, and quality of life.
  
  
  
  Eighty-nine subjects completed the study, of whom 46 were randomized to the intervention arm. Compared to controls, we found improvements in self-reported medication adherence (P = .011), quality of life (P = .037), and self-efficacy (P = .016). Subjects reported high satisfaction with MMH; however, the level of system usage varied widely, with lower use among African American patients.
  
  
  
  MMH was associated with improved medication adherence, perceived quality of life, and self-efficacy.Trial Registration This project was registered under http://clinicaltrials.gov/ identifier NCT01730235.
authors.affiliation: Department of Biomedical Informatics at Vanderbilt University School of Medicine, Nashville, TN, USA Department of Pediatrics at Vanderbilt University School of Medicine, Nashville, TN, USA kevin.johnson@vanderbilt.edu.
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Johnson
authors.affiliation: Department of Pediatrics at Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Barron L
authors.initials: BL
authors.lastname: Patterson
authors.affiliation: Department of Biomedical Informatics at Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Yun-Xian
authors.initials: YX
authors.lastname: Ho
authors.affiliation: Department of Biomedical Informatics at Vanderbilt University School of Medicine, Nashville, TN, USA Department of Biostatistics at Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Qingxia
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Biostatistics at Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Nian
authors.affiliation: Department of Biomedical Informatics at Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Coda L
authors.initials: CL
authors.lastname: Davison
authors.affiliation: Department of Anesthesiology at Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Slagle
authors.affiliation: Department of Biomedical Informatics at Vanderbilt University School of Medicine, Nashville, TN, USA School of Nursing at Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Shelagh A
authors.initials: SA
authors.lastname: Mulvaney
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000188:drug therapy*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D057194:Intention to Treat Analysis; D020407:Internet; D008297:Male; D055118:Medication Adherence; D063731:Mobile Applications; D011788:Quality of Life; D017010:Reminder Systems; D012648:Self Care; D060145:Text Messaging
keywords: adherence; adolescent; asthma; biomedical informatics; clinical trial; mHealth; mobile technology; personal health records