title: Pre-frontal-insular-cerebellar modifications correlate with disgust feeling blunting after subthalamic stimulation: A positron emission tomography study in Parkinson's disease.
abstract: Subthalamic nucleus (STN) deep brain stimulation (DBS) has recently advanced our understanding of the major role played by this basal ganglion in human emotion. Research indicates that STN DBS can induce modifications in all components of emotion, and neuroimaging studies have shown that the metabolic modifications correlated with these emotional disturbances following surgery are both task- and sensory input-dependent. Nevertheless, to date, these modifications have not been confirmed for all emotional components, notably subjective emotional experience, or feelings. To identify the neural network underlying the modification of feelings following STN DBS, we assessed 16 patients with Parkinson's disease before and after surgery, using both subjective assessments of emotional experience and18[F]fluorodeoxyglucose positron emission tomography (18FDG-PET). The patients viewed six film excerpts intended to elicit happy, angry, fearful, sad, disgusted, and neutral feelings, and they self-rated the intensity of these feelings. After DBS, there was a significant reduction in the intensity of the disgust feeling. Correlations were observed between decreased disgust experience and cerebral glucose metabolism (FDG uptake) in the bilateral pre-frontal cortices (orbitofrontal, dorsolateral, and inferior frontal gyri), bilateral insula, and right cerebellum. We suggest that the STN contributes to the synchronization process underlying the emergence of feelings.
authors.affiliation: 'Behaviour and Basal Ganglia' Research Unit, University of Rennes 1, Rennes University Hospital, France.|Neurology Department, Rennes University Hospital, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Ory
authors.affiliation: 'Behaviour and Basal Ganglia' Research Unit, University of Rennes 1, Rennes University Hospital, France.|Nuclear Medicine Department, Eugène Marquis Centre, Rennes, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Le Jeune
authors.affiliation: MediCIS, INSERM, Faculty of Medicine, University of Rennes I, France.|Neurosurgery Department, Rennes University Hospital, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Haegelen
authors.affiliation: UMR CNRS 7295, Centre for Research on Cognition and Learning, Poitiers, France.
authors.forename: Siobhan
authors.initials: S
authors.lastname: Vicente
authors.affiliation: Department of Psychology, University of Louvain-La-Neuve, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Philippot
authors.affiliation: 'Behaviour and Basal Ganglia' Research Unit, University of Rennes 1, Rennes University Hospital, France.
authors.forename: Thibaut
authors.initials: T
authors.lastname: Dondaine
authors.affiliation: MediCIS, INSERM, Faculty of Medicine, University of Rennes I, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Jannin
authors.affiliation: 'Behaviour and Basal Ganglia' Research Unit, University of Rennes 1, Rennes University Hospital, France.|Neurology Department, Rennes University Hospital, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Drapier
authors.affiliation: 'Behaviour and Basal Ganglia' Research Unit, University of Rennes 1, Rennes University Hospital, France.|Adult Psychiatry Department, Guillaume Régnier Hospital, Rennes, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Drapier
authors.affiliation: 'Behaviour and Basal Ganglia' Research Unit, University of Rennes 1, Rennes University Hospital, France.|Physiology Department, Rennes University Hospital, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Sauleau
authors.affiliation: 'Behaviour and Basal Ganglia' Research Unit, University of Rennes 1, Rennes University Hospital, France.|Neurology Department, Rennes University Hospital, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Vérin
authors.affiliation: 'Neuroscience of Emotion and Affective Dynamics' Laboratory, Department of Psychology and Swiss Centre for Affective Sciences, University of Geneva, Switzerland.
authors.forename: Julie
authors.initials: J
authors.lastname: Péron
mesh_terms: D002531:Cerebellum / Q000378:metabolism / Q000502:physiology*; D002540:Cerebral Cortex / Q000378:metabolism / Q000502:physiology*; D046690:Deep Brain Stimulation; D004644:Emotions / Q000502:physiology*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000523:psychology* / Q000628:therapy; D049268:Positron-Emission Tomography; D017397:Prefrontal Cortex / Q000378:metabolism / Q000502:physiology*; D020531:Subthalamic Nucleus / Q000502:physiology*
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: 18[F]fluorodeoxyglucose positron emission tomography; cerebellum; emotion; feelings; insula; orbitofrontal cortex; subthalamic nucleus