title: Deletion of the putative tumor suppressor gene, G0s2, does not affect progression of Eμ-Myc driven lymphomas in mice.
abstract: Several recent reports have suggested that the G0/G1 switch gene 2 (G0S2) is a potential tumor suppressor in leukemia. Here we show that deletion of the G0s2 gene in mouse does not affect the latency of cancer progression in the Eμ-Myc model of lymphoma. Our findings do not rule out the possibility that G0S2 may be playing a role in other forms of leukemia, but clearly show that the commonly used Eμ-Myc transgenic is not the correct model to conduct studies on G0s2.
authors.affiliation: Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada.
authors.forename: Rachid
authors.initials: R
authors.lastname: Zagani
authors.affiliation: Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Gamache
authors.affiliation: Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada; Department of Biochemistry, McGill University, Montréal, Québec, Canada. Electronic address: jose.teodoro@mcgill.ca.
authors.forename: Jose G
authors.initials: JG
authors.lastname: Teodoro
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics*; D017353:Gene Deletion; D016259:Genes, myc; D008223:Lymphoma / Q000235:genetics / Q000473:pathology*; D051379:Mice; D018345:Mice, Knockout
chemical_list: D018797:Cell Cycle Proteins; C508072:G0S2 protein, mouse
keywords: Eμ-Myc; G0S2; Leukemia; Lymphoma; Mouse model; Transgenic models; Tumor suppressor