title: Relationship of Angiogenesis and Oral Squamous Cell Carcinoma.
abstract: Angiogenesis is an important aspect of a variety of physiological and pathological processes; and depends on the alteration of the balance between pro-angiogenic and anti-angiogenic factors. The role of angiogenesis in the progression and metastasis of neoplasm is a well established phenomenon. With regards to oral squamous cell carcinoma, it is a field of ongoing research and requires validation for it being used as a mode of anti-cancer therapy. This review focuses on the concept of angiogenesis, the factors associated with it, the relationship of angiogenesis with oral epithelial dysplasia and oral squamous cell carcinoma; the methods of studying angiogenesis and anti angiogenic therapy.
authors.affiliation: Department of Oral Histology and Pathology College of Dental Surgery, BP Koirala Institute of Health Sciences, Dharan, Sunsari, Nepal.
authors.forename: V
authors.initials: V
authors.lastname: Marla
authors.affiliation: Department of Oral Pathology and Microbiology SDM College of Dental Sciences, Sattur, Dharwad, Karnataka.
authors.forename: V
authors.initials: V
authors.lastname: Hegde
authors.affiliation: Department of Oral Histology and Pathology College of Dental Surgery, BP Koirala Institute of Health Sciences, Dharan, Sunsari, Nepal.
authors.forename: A
authors.initials: A
authors.lastname: Shrestha
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D042461:Vascular Endothelial Growth Factor A