title: Interphase H1 phosphorylation: Regulation and functions in chromatin.
abstract: Many metazoan cell types differentially express multiple non-allelic amino acid sequence variants of histone H1. Although early work revealed that H1 variants, collectively, are phosphorylated during interphase and mitosis, differences between individual H1 variants in the sites they possess for mitotic and interphase phosphorylation have been elucidated only relatively recently. Here, we review current knowledge on the regulation and function of interphase H1 phosphorylation, with a particular emphasis on how differences in interphase phosphorylation among the H1 variants of mammalian cells may enable them to have differential effects on transcription and other chromatin processes.
authors.affiliation: Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, USA.
authors.forename: Ruiqi
authors.initials: R
authors.lastname: Liao
authors.affiliation: Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, USA; Institute for Genomic Biology, University of Illinois at Urbana Champaign, USA. Electronic address: cmizzen@life.uiuc.edu.
authors.forename: Craig A
authors.initials: CA
authors.lastname: Mizzen
mesh_terms: D000818:Animals; D002843:Chromatin / Q000502:physiology*; D006657:Histones / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D007399:Interphase; D010766:Phosphorylation; D006656:Protamine Kinase / Q000502:physiology; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D006657:Histones; D006656:Protamine Kinase
keywords: Cell cycle; Chromatin structure; Epigenetics; Gene regulation; Histone H1; Histone phosphorylation