title: Terpenoids from Diplophyllum taxifolium with quinone reductase-inducing activity.
abstract: Two new ent-prenylaromadendrane-type diterpenoids, diplotaxifols A (1) and B (2), a new ent-eudesmol, ent-eudesma-4(15),11(13)-dien-6α,12-diol (3), eight new eudesmanolides enantiomers (4-11) of the corresponding compounds from higher plants along with four known ent-eudesmanolides (12-15) were isolated from the 95% EtOH extract of Chinese liverwort Diplophyllum taxifolium. Their structures were elucidated on the basis of MS, NMR and IR spectral data, and confirmed by single-crystal X-ray diffraction analysis. The quinone reductase-inducing activity of the compounds was evaluated.
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
authors.forename: Jiao-Zhen
authors.initials: JZ
authors.lastname: Zhang
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
authors.forename: Jin-Chuan
authors.initials: JC
authors.lastname: Zhou
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Shen
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. Electronic address: louhongxiang@sdu.edu.cn.
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D035926:Hepatophyta / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D064209:Phytochemicals / Q000737:chemistry / Q000302:isolation & purification; D011808:Quinone Reductases / Q000378:metabolism; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D004224:Diterpenes; D064209:Phytochemicals; D013729:Terpenes; D011808:Quinone Reductases
keywords: Liverwort; Quinone reductase; ent-Eudesmane; ent-Prenylaromadendrane