title: [DYNAMICS OF CYTOKINE CONCENTRATION IN THE BLOOD OF RATS WITH VARIOUS BEHAVIORAL CHARACTERISTICS AFTER ACUTE EMOTIONAL STRESS].
abstract: This work was designed to study a change in cytokine content in the peripheral blood of behaviorally passive and active Wistar rats at various time intervals after acute stress on the model of night-time immobilization. A decrease in the concentration of most pro- and anti-inflammatory cytokines in passive animals was most pronounced immediately and, particularly, 3 days after stress exposure. Variations in the blood cytokine profile after experimental stress were lower in behaviorally active specimens. A statistically significant decrease was observed only in the amount of a proinflammatory cytokine IL-1α and anti-inflammatory cytokines IL-4 and IL-13. As differentiated from passive rats, these changes in active specimens were most pronounced 1 day after negative emotiogenic exposure. Our results illustrate a specific involvement of immunoactive substances in the systemic regulation of physiological functions and development of individual resistance to the negative consequences of stress.
authors.forename: S S
authors.initials: SS
authors.lastname: Pertsov
authors.forename: L S
authors.initials: LS
authors.lastname: Kalinichenko
authors.forename: E V
authors.initials: EV
authors.lastname: Koplik
authors.forename: I V
authors.initials: IV
authors.lastname: Alekseeva
authors.forename: N V
authors.initials: NV
authors.lastname: Kirbaeva
authors.forename: N E
authors.initials: NE
authors.lastname: Sharanova
authors.forename: A V
authors.initials: AV
authors.lastname: Vasil'ev
mesh_terms: D000818:Animals; D005106:Exploratory Behavior / Q000502:physiology; D007103:Immobilization; D018793:Interleukin-13 / Q000097:blood*; D053582:Interleukin-1alpha / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000097:blood* / Q000276:immunology / Q000503:physiopathology
chemical_list: D018793:Interleukin-13; D053582:Interleukin-1alpha; D015847:Interleukin-4