title: Super-oxide anion production and antioxidant enzymatic activities associated with the executive functions in peripheral blood mononuclear cells of healthy adult samples.
abstract: Executive Functions (EFs) involve a set of high cognitive abilities impairment which have been successfully related to a redox omeostasis imbalance in several psychiatric disorders. Firstly, we aimed to investigate the relationship between executive functioning and some oxidative metabolism parameters in Peripheral Blood Mononuclear Cells (PBMCs) from healthy adult samples. The Brown Attention-Deficit Disorder Scales were administered to assess five specific facets of executive functioning. Total superoxide anion production, Super Oxide Dismutase (SOD), Catalase (CAT), Glutathione Reductase (GR) and Glutathione Peroxidase (GPx) activities were evaluated on proteins extracted from the PBMCs. We found significant positive correlations between superoxide anion production and the total score of the 'Brown' Scale and some of its clusters. The GPx and CAT activities were negatively associated with the total score and some clusters. In a linear regression analysis, these biological variables were indicated as the most salient predictors of the total score, explaining the 24% variance (adjusted R(2)=0.24, ANOVA, p<.001). This study provides novel evidence that Executive Functions have underpinnings in the oxidative metabolism, as ascertained in healthy subjects.
authors.affiliation: School of Medicine and Health Sciences, University G. d'Annunzio, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pesce
authors.affiliation: School of Medicine and Health Sciences, University G. d'Annunzio, Italy. Electronic address: alessia.rizzuto@unich.it.
authors.forename: A
authors.initials: A
authors.lastname: Rizzuto
authors.affiliation: School of Medicine and Health Sciences, University G. d'Annunzio, Italy.
authors.forename: I
authors.initials: I
authors.lastname: La Fratta
authors.affiliation: School of Medicine and Health Sciences, University G. d'Annunzio, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Tatangelo
authors.affiliation: School of Medicine and Health Sciences, University G. d'Annunzio, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Campagna
authors.affiliation: School of Medicine and Health Sciences, University G. d'Annunzio, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Iannasso
authors.affiliation: School of Medicine and Health Sciences, University G. d'Annunzio, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ferrone
authors.affiliation: School of Medicine and Health Sciences, University G. d'Annunzio, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Franceschelli
authors.affiliation: School of Medicine and Health Sciences, University G. d'Annunzio, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Speranza
authors.affiliation: School of Medicine and Health Sciences, University G. d'Annunzio, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Patruno
authors.affiliation: School of Medicine and Health Sciences, University G. d'Annunzio, Italy.
authors.forename: M A
authors.initials: MA
authors.lastname: De Lutiis
authors.affiliation: School of Medicine and Health Sciences, University G. d'Annunzio, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Felaco
authors.affiliation: School of Medicine and Health Sciences, University G. d'Annunzio, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Grilli
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000097:blood; D056344:Executive Function; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D013482:Superoxide Dismutase / Q000097:blood; D013481:Superoxides / Q000378:metabolism*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D013481:Superoxides; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase
keywords: Catalase; Executive functions; Glutathione peroxidase; PBMCs; Superoxide anion