title: Extracellular Matrix and Regenerative Therapies from the Cardiac Perspective.
abstract: Cardiovascular diseases are the leading cause of death and a major cause of financial burden. Regenerative therapies for heart diseases bring the promise of alternative treatment modalities for myocardial infarction, ischemic heart disease, and congestive heart failure. Although, clinical trials attest to the safety of stem cell injection therapies, researchers need to overcome the underlying mechanisms that are limiting the success of future regenerative options. This article aims to review the basic scientific concepts in the field of mechanobiology and the effects of extracellular functions on stem cell fate.
authors.affiliation: Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Ankara University Faculty of Science, and Ankara University Stem Cell Institute, Degol Caddesi, Tandogan, 06100, Ankara, Turkey.
authors.forename: Arin
authors.initials: A
authors.lastname: Dogan
authors.affiliation: Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Ankara University Faculty of Science, and Ankara University Stem Cell Institute, Degol Caddesi, Tandogan, 06100, Ankara, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Parmaksız
authors.affiliation: Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Ankara University Faculty of Science, and Ankara University Stem Cell Institute, Degol Caddesi, Tandogan, 06100, Ankara, Turkey.
authors.forename: A Eser
authors.initials: AE
authors.lastname: Elçin
authors.affiliation: Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Ankara University Faculty of Science, and Ankara University Stem Cell Institute, Degol Caddesi, Tandogan, 06100, Ankara, Turkey. elcinmurat@gmail.com.
authors.forename: Y Murat
authors.initials: YM
authors.lastname: Elçin
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006331:Heart Diseases / Q000628:therapy*; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods
keywords: Cardiac tissue engineering; Extracellular matrix; Heart; Heart failure; Mechanotransduction; Myocardial infarction; Stem cell therapy; Tensegrity