title: 68Ga-NOTA-Exendin-4 PET/CT in Localization of an Occult Insulinoma and Appearance of Coexisting Esophageal Carcinoma.
abstract: A 61-year-old woman with biochemically proven endogenous hyperinsulinemic hypoglycemia and negative conventional imaging underwent 68Ga-NOTA-exendin-4 PET/CT for localization of insulinoma. Focal intense radioactivity in the tail of the pancreas was observed that was subsequently confirmed as insulinoma pathologically after surgical resection. In addition, esophageal carcinoma with lymph node and hepatic metastases was found by FDG PET/CT in the same patient. Neither the primary carcinoma nor the metastases showed increased radioactivity on 68Ga-NOTA-exendin-4 PET/CT.
authors.affiliation: From the Departments of *Nuclear Medicine, and †Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, People's Republic of China; and ‡Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Luo
authors.forename: Naishi
authors.initials: N
authors.lastname: Li
authors.forename: Dale O
authors.initials: DO
authors.lastname: Kiesewetter
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
authors.forename: Fang
authors.initials: F
authors.lastname: Li
mesh_terms: D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000556:secondary; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D000077270:Exenatide; D005260:Female; D006571:Heterocyclic Compounds; D006573:Heterocyclic Compounds, 1-Ring; D006801:Humans; D007340:Insulinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D008875:Middle Aged; D064847:Multimodal Imaging; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed; D014688:Venoms
chemical_list: C000612060:68Ga-NOTA-exendin-4; D056831:Coordination Complexes; D006571:Heterocyclic Compounds; D006573:Heterocyclic Compounds, 1-Ring; D010455:Peptides; D019275:Radiopharmaceuticals; D014688:Venoms; C048993:1,4,7-triazacyclononane-N,N',N''-triacetic acid; D000077270:Exenatide