title: [Ovarian cancer is in many ways a heterogeneous disease].
abstract: Ovarian cancer develops due to a complex interplay between hereditary and environmental factors. Although often described as one disease, ovarian cancer is actually a group of distinct tumor types. Recent research has indicated that a large percentage of ovarian cancers may originate from the fallopian tube epithelium. Although most cancers develop in patients without a known hereditary syndrome, it is clear that the number of familial cancers is larger than previously supposed. The two most common hereditary syndromes where ovarian cancer can develop are hereditary breast ovarian cancer syndrome (HBOC) and Lynch syndrome.
authors.affiliation: clinical sciences - oncology and pathology Lund, Sweden clinical sciences - oncology and pathology Lund, Sweden.
authors.forename: Susanne
authors.initials: S
authors.lastname: Malander
authors.affiliation: Enheten för bröst- och gynekologisk cancer, Radiumhemmet - Karolinska sjukhuset Solna, Sweden Enheten för bröst- och gynekologisk cancer, Radiumhemmet - Karolinska sjukhuset Solna, Sweden.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Hjerpe
authors.affiliation: Enheten för cytologi och patologi - Karolinska sjukhuset Solna, Sweden Karolinska Universitetssjukhuset - Klinik för patologi och cytologi Stockholm, Sweden.
authors.forename: Joseph
authors.initials: J
authors.lastname: Carlson
authors.affiliation: Avdelningen för Onkologi och patologi - Lunds Universitet, Medicon Village Lund, Sweden Avdelningen för Onkologi och patologi - Lunds Universitet, Medicon Village Lund, Sweden.
authors.forename: Åke
authors.initials: Å
authors.lastname: Borg
mesh_terms: D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008019:Life Style; D009154:Mutation; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000235:genetics / Q000473:pathology; D065840:Protective Factors; D012307:Risk Factors