title: Perioperative Characteristics of Siblings Undergoing Liver or Kidney Transplant.
abstract: OBJECTIVE
  Reasons for chronic liver and kidney failure may vary; sometimes more than 1 family member may be affected, and may require a transplant. The aim of this study was to examine the similarities or differences between the perioperative characteristics of siblings undergoing liver or kidney transplant.
  
  
  METHODS
  The medical records of 6 pairs of siblings who underwent liver transplant and 4 pairs of siblings who underwent kidney transplant at Baskent University Hospital between 1989 and 2014 were retrospectively analyzed. Collected data included demographic features; comorbidities; reasons for liver and kidney failure; perioperative laboratory values; intraoperative hemodynamic parameters; use and volume of crystalloids, colloids, blood products, cell saver system, and albumin; duration of anesthesia; urine output; and postoperative follow-up data.
  
  
  RESULTS
  The mean age of the 6 sibling pairs who underwent liver transplant was 16.3 ± 12.2 years. All 12 patients had Child-Pugh grade B cirrhosis, with mean disease duration of 7.8 ± 3.9 years. There were no significant differences between siblings with respect to intraoperative blood product transfusion, crystalloid and colloid fluid replacements, hypotension frequency, blood gas analyses, urinary output, duration of anhepatic phase, inotropic agent administration, postoperative laboratory values, need for mechanical ventilation and vasopressors, occurrence of acute renal failure and infections, and duration intensive care unit stay (P > .05). The mean age of the 4 sibling pairs who underwent kidney transplant was 21.3 ± 6.4 years, with mean duration of renal insufficiency of 2.2 ± 1.6 years. There were no significant differences between siblings with respect to intraoperative crystalloid and colloid fluid administration, duration of anesthesia, intraoperative mannitol and furosemide administration, and postoperative laboratory values (P > .05).
  
  
  CONCLUSIONS
  In conclusion, the 6 sibling pairs who underwent liver transplant and 4 sibling pairs who underwent kidney transplant in our cohort had similar perioperative characteristics.
authors.affiliation: From the Department of Anesthesiology and Critical Care Medicine, Baskent University Faculty of Medicine, Ankara, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Ersoy
authors.forename: Aycan
authors.initials: A
authors.lastname: Ozdemirkan
authors.forename: Arash
authors.initials: A
authors.lastname: Pirat
authors.forename: Adnan
authors.initials: A
authors.lastname: Torgay
authors.forename: Gulnaz
authors.initials: G
authors.lastname: Arslan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Haberal
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006785:Hospitals, University; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods*; D008499:Medical Records; D019990:Perioperative Care; D011183:Postoperative Complications / Q000209:etiology / Q000628:therapy; D051437:Renal Insufficiency / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D012189:Retrospective Studies; D035781:Siblings; D016896:Treatment Outcome; D014421:Turkey; D055815:Young Adult