title: [Microscopic study and microanalysis of platelets in vivo].
abstract: Under physiological and pathological conditions, complex cellular interplays take place in living animals. However, the conventional microscope using two-dimensional analysis is not sufficient for analyzing cell dynamics and functions in vivo. Thus, we improved the in vivo imaging technique based on multi-photon microscopy, and we then identified single platelet behaviors in the developing thrombus. We utilized XYZT high-speed imaging, which visualized platelet fate in vivo. This novel technique is anticipated to provide new insights into physiological and pathological conditions involving platelets.
authors.affiliation: Center for Molecular Medicine, Jichi Medical University.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishimura
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000166:cytology*; D042783:Endothelial Cells / Q000166:cytology; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D008853:Microscopy / Q000379:methods*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species