title: Fine-needle aspiration of soft tissue myoepithelioma.
abstract: Soft tissue myoepithelioma is a rare neoplasm composed of myoepithelial cells. We describe the cytologic features of a soft tissue myoepithelioma arising in the right lower chest wall in a 65-year-old woman. The fine-needle aspiration (FNA) smears showed round to oval, spindle, epithelioid, and plasmacytoid cells in the myxoid background. The nuclei were uniform, round to ovoid, with finely distributed chromatin and eosinophilic or pale cytoplasm, and resembled lobular carcinoma of breast. Ultrasound guided core biopsy showed the tumor cells had bland cytologic features, arranged in small cords, nests, and dissociated single cells, with no glandular differentiation or breast tissue seen. The tumor cells demonstrated immunoreactivity for cytokeratin (AE1/AE3) and glial fibrillary acidic protein, but were negative for estrogen receptor. Fluorescence in situ hybridization demonstrated the EWSR1 rearrangement, confirming the diagnosis of myoepithelioma.
authors.affiliation: Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Pathology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.|Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada.
authors.forename: Tracy
authors.initials: T
authors.lastname: Tucker
authors.affiliation: Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.|Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada.
authors.forename: Tony L
authors.initials: TL
authors.lastname: Ng
authors.affiliation: Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.|Department of Pathology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
authors.forename: Carlos F
authors.initials: CF
authors.lastname: Villamil
authors.affiliation: Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.|Department of Pathology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
authors.forename: Malcolm M
authors.initials: MM
authors.lastname: Hayes
mesh_terms: D000368:Aged; D044963:Biopsy, Fine-Needle; D005260:Female; D006801:Humans; D009208:Myoepithelioma / Q000000981:diagnostic imaging / Q000473:pathology*; D011877:Radionuclide Imaging; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*
keywords: cytology; fine-needle aspiration; lobular carcinoma; myoepithelioma; soft tissue