title: New laurane-type sesquiterpenoids from the Chinese red alga Laurencia okamurai Yamada.
abstract: Two new laurane-type sesquiterpenoids, debromo-3α-hydroperoxy-3-epiaplysin (1) and debromo-3β-hydroperoxyaplysin (2), together with seven known related compounds (3-9), were isolated from the Chinese red alga Laurencia okamurai. Their structures were elucidated by detailed analysis of spectroscopic data and by comparison with the literature. In bioassay, compounds 2, 4, 8, and 9 exhibited significant PTP1B inhibitory activity with IC50 values ranging from 4.9 to 14.9 μg/ml.
authors.forename: Xiao-Lu
authors.initials: XL
authors.lastname: Li
authors.forename: Wen-Fei
authors.initials: WF
authors.lastname: He
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Le-Fu
authors.initials: LF
authors.lastname: Lan
authors.forename: Xu-Wen
authors.initials: XW
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
mesh_terms: D002681:China; D020128:Inhibitory Concentration 50; D044722:Laurencia / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D012717:Sesquiterpenes; C000607637:debromo-3alpha-hydroperoxy-3-epiaplysin; C000607638:debromo-3beta-hydroperoxyaplysin; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1
keywords: Chinese red algae; Laurencia okamurai; PTP1B inhibitor; laurane; sesquiterpene