title: Therapeutic drug monitoring of cerebrospinal fluid vancomycin concentration during intraventricular administration.
abstract: Limited data are available on intraventricular vancomycin dosing for meningitis. This study explored clinical characteristics that correlated with cerebrospinal fluid (CSF) concentrations. Over a nine-year period, 13 patients with 34 CSF vancomycin concentrations were evaluated. CSF output and time from dose correlated with CSF vancomycin concentration. No relationship was seen with regards to CSF protein, white blood cell count or glucose.
authors.affiliation: Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA. Electronic address: popad@ccf.org.
authors.forename: D
authors.initials: D
authors.lastname: Popa
authors.affiliation: Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: L
authors.initials: L
authors.lastname: Loewenstein
authors.affiliation: Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: S W
authors.initials: SW
authors.lastname: Lam
authors.affiliation: Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Neuner
authors.affiliation: Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Ahrens
authors.affiliation: Department of Infectious Diseases, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: A
authors.initials: A
authors.lastname: Bhimraj
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000493:pharmacokinetics*; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy*; D008875:Middle Aged; D012189:Retrospective Studies; D014640:Vancomycin / Q000032:analysis* / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin
keywords: Intraventricular; Meningitis; Therapeutic drug monitoring; Vancomycin; Ventriculitis