title: Combined rTMS treatment targeting the Anterior Cingulate and the Temporal Cortex for the Treatment of Chronic Tinnitus.
abstract: Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a tinnitus treatment option. Promising results have been obtained by consecutive stimulation of lateral frontal and auditory brain regions. We investigated a combined stimulation paradigm targeting the anterior cingulate cortex (ACC) with double cone coil rTMS, followed by stimulation of the temporo-parietal junction area with a figure-of-eight coil. The study was conducted as a randomized, double-blind pilot trial in 40 patients suffering from chronic tinnitus. We compared mediofrontal stimulation with double-cone-coil, (2000 stimuli, 10 Hz) followed by left temporo-parietal stimulation with figure-of-eight-coil (2000 stimuli, 1 Hz) to left dorsolateral-prefrontal-cortex stimulation with figure-of-eight-coil (2000 stimuli, 10 Hz) followed by temporo-parietal stimulation with figure-of-eight-coil (2000 stimuli, 1 Hz). The stimulation was feasible with comparable dropout rates in both study arms; no severe adverse events were registered. Responder rates did not differ in both study arms. There was a significant main effect of time for the change in the TQ score, but no significant time x group interaction. This pilot study demonstrated the feasibility of combined mediofrontal/temporoparietal-rTMS-stimulation with double cone coil in tinnitus patients but failed to show better outcome compared to an actively rTMS treated control group.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.|Interdisciplinary Tinnitus Center of the University of Regensburg, Regensburg, Germany.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Kreuzer
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.|Interdisciplinary Tinnitus Center of the University of Regensburg, Regensburg, Germany.
authors.forename: Astrid
authors.initials: A
authors.lastname: Lehner
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.|Interdisciplinary Tinnitus Center of the University of Regensburg, Regensburg, Germany.
authors.forename: Winfried
authors.initials: W
authors.lastname: Schlee
authors.affiliation: Department of Otorhinolaryngology, University of Regensburg, Regensburg, Germany.|Interdisciplinary Tinnitus Center of the University of Regensburg, Regensburg, Germany.
authors.forename: Veronika
authors.initials: V
authors.lastname: Vielsmeier
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.|Interdisciplinary Tinnitus Center of the University of Regensburg, Regensburg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Schecklmann
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.|Interdisciplinary Tinnitus Center of the University of Regensburg, Regensburg, Germany.
authors.forename: Timm B
authors.initials: TB
authors.lastname: Poeppl
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.|Department of Psychiatry, Psychosomatics and Psychotherapy, kbo-Lech-Mangfall-Klinik Agatharied, Germany.|Interdisciplinary Tinnitus Center of the University of Regensburg, Regensburg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Landgrebe
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Rupprecht
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.|Interdisciplinary Tinnitus Center of the University of Regensburg, Regensburg, Germany.
authors.forename: Berthold
authors.initials: B
authors.lastname: Langguth
mesh_terms: D003131:Combined Modality Therapy / Q000379:methods; D004311:Double-Blind Method; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D017397:Prefrontal Cortex / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology*; D014012:Tinnitus / Q000628:therapy*; D050781:Transcranial Magnetic Stimulation / Q000379:methods; D016896:Treatment Outcome