title: Feasibility of progesterone treatment for ischaemic stroke.
abstract: Two multi-centre phase III clinical trials examining the protective potential of progesterone following traumatic brain injury have recently failed to demonstrate any improvement in outcome. Thus, it is timely to consider how this impacts on the translational potential of progesterone treatment for ischaemic stroke. A wealth of experimental evidence supports the neuroprotective properties of progesterone, and associated metabolites, following various types of central nervous system injury. In particular, for ischaemic stroke, studies have also begun to reveal possible mechanisms of such neuroprotection. However, the results in traumatic brain injury now question whether further clinical development of progesterone for ischaemic stroke is relevant.
authors.affiliation: Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK cg95@le.ac.uk.
authors.forename: Claire L
authors.initials: CL
authors.lastname: Gibson
authors.affiliation: Stroke, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.
authors.forename: Philip M
authors.initials: PM
authors.lastname: Bath
mesh_terms: D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D001930:Brain Injuries / Q000188:drug therapy* / Q000503:physiopathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D017326:Clinical Trials, Phase III as Topic; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D011374:Progesterone / Q000627:therapeutic use*; D020521:Stroke / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D018696:Neuroprotective Agents; D011374:Progesterone
keywords: Steroids; acute stroke; cerebrovascular disease; drug trials; focal ischaemia