title: Association of calprotectin with leukocyte chemotactic and inflammatory mediators following acute aerobic exercise.
abstract: The objective of this study was to examine whether acute aerobic exercise-mediated calprotectin in plasma would be associated with monocyte chemotactic protein-1 (MCP-1), myeloperoxidase (MPO), and interleukin-6 (IL-6) in healthy individuals. Eleven healthy participants, aged 18 to 30 years, were recruited to perform a 30-min bout of aerobic exercise at 75% maximal oxygen uptake. Acute aerobic exercise elicited a significant elevation across time in plasma calprotectin, MCP-1, MPO, and IL-6. Body mass index (BMI) was positively correlated with calprotectin area-under-the-curve with "respect to increase" (AUCi) and IL-6 AUCi. Furthermore, calprotectin AUCi was positively correlated with IL-6 AUCi and MPO AUCi, even after controlling for BMI. Although MPO AUCi was positively correlated with IL-6 AUCi, this relationship no longer existed after controlling for BMI. These results suggest that acute aerobic exercise could mediate innate immune response associated with calprotectin and its related leukocyte chemotactic and inflammatory mediators, especially in individuals with elevated BMI.
authors.affiliation: a Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA.
authors.forename: Arun
authors.initials: A
authors.lastname: Maharaj
authors.affiliation: a Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA.|b Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, VA 23284, USA.
authors.forename: Aaron L
authors.initials: AL
authors.lastname: Slusher
authors.affiliation: a Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Zourdos
authors.affiliation: a Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Whitehurst
authors.affiliation: a Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA.
authors.forename: Brandon G
authors.initials: BG
authors.lastname: Fico
authors.affiliation: a Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL 33431, USA.
authors.forename: Chun-Jung
authors.initials: CJ
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D015992:Body Mass Index; D018932:Chemokine CCL2 / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D039841:Leukocyte L1 Antigen Complex / Q000097:blood*; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D010101:Oxygen Consumption; D009195:Peroxidase / Q000097:blood; D055815:Young Adult
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D015850:Interleukin-6; D039841:Leukocyte L1 Antigen Complex; D009195:Peroxidase
keywords: S100A8/A9; activité physique; inflammation; interleukin-6; interleukine-6; monocyte chemoattractant protein-1; myeloperoxidase; myéloperoxydase; physical activity; protéine chimiotactique monocytaire-1