title: An efficient approach for the construction of trifluoromethylated all-carbon quaternary stereocenters: enantioselective Ni(ii)-catalyzed Michael addition of 2-acetyl azaarene to β,β-disubstituted nitroalkenes.
abstract: The first example of a highly enantioselective Michael addition of 2-acetyl azaarenes with β,β-disubstituted nitroalkenes was achieved using a Ni(acac)2-bisoxazoline complex as a catalyst, which afforded chiral compounds with an all-carbon quaternary stereocenter bearing a CF3 group in good yields with excellent enantioselectivities (up to >99% ee). This reaction, featuring mild conditions, excellent enantioselectivity and broad generality, provides a new efficient strategy for the construction of trifluoromethylated all-carbon quaternary stereocenters.
authors.affiliation: Department of Applied Chemistry, China Agricultural University, West Yuanmingyuan Rd 2, Beijing 100193, People''s Republic of China. fubinchem@cau.edu.cn.
authors.forename: Xuhe
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of Applied Chemistry, China Agricultural University, West Yuanmingyuan Rd 2, Beijing 100193, People''s Republic of China. fubinchem@cau.edu.cn.
authors.forename: Hongli
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Applied Chemistry, China Agricultural University, West Yuanmingyuan Rd 2, Beijing 100193, People''s Republic of China. fubinchem@cau.edu.cn.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Applied Chemistry, China Agricultural University, West Yuanmingyuan Rd 2, Beijing 100193, People''s Republic of China. fubinchem@cau.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Xie
authors.affiliation: Department of Applied Chemistry, China Agricultural University, West Yuanmingyuan Rd 2, Beijing 100193, People''s Republic of China. fubinchem@cau.edu.cn.
authors.forename: Zhaohai
authors.initials: Z
authors.lastname: Qin
authors.affiliation: Department of Applied Chemistry, China Agricultural University, West Yuanmingyuan Rd 2, Beijing 100193, People''s Republic of China. fubinchem@cau.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Fu