title: FREE RADICALS IN THERMALLY STERILIZED ACIDUM BORICUM AND OPTIMIZATION OF THIS PROCESS.
abstract: Free radicals formation in the acidum boricum (AB) during thermal sterilization process was examined by an X-band (9.3 GHz) electron paramagnetic resonance (EPR) spectroscopy. Acidum boricum was sterilized according to the pharmacopea norms at temperatures 160°C (120 min), 170°C (60 min), and 180°C (30 min). Free radicals (~10(17) spin/g) were thermally formed in these drug. The free radicals system revealed complex character, and the asymmetrical EPR spectra were measured. Mainly oxygen free radicals exist in the tested heated AB. Slower spin-lattice relaxation processes exist in AB sterilized at 160, 170 and 180°C. AB may be sterilized at temperatures 160, 170 and 180°C. For AB thermal sterilization at temperature 170°C is recommended. Free radicals concentrations changes during storage of the examined AB, and probably interactions with oxygen molecules may be responsible for this effect.
authors.forename: Paweł
authors.initials: P
authors.lastname: Ramos
authors.forename: Barbara
authors.initials: B
authors.lastname: Pilawa
mesh_terms: D001896:Boron Compounds / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D006358:Hot Temperature; D013242:Sterilization
chemical_list: D001896:Boron Compounds; D005609:Free Radicals