title: Cortico-Basal Ganglia Circuit Function in Psychiatric Disease.
abstract: Circuit dysfunction models of psychiatric disease posit that pathological behavior results from abnormal patterns of electrical activity in specific cells and circuits in the brain. Many psychiatric disorders are associated with abnormal activity in the prefrontal cortex and in the basal ganglia, a set of subcortical nuclei implicated in cognitive and motor control. Here we discuss the role of the basal ganglia and connected prefrontal regions in the etiology and treatment of obsessive-compulsive disorder, anxiety, and depression, emphasizing mechanistic work in rodent behavioral models to dissect causal cortico-basal ganglia circuits underlying discrete behavioral symptom domains relevant to these complex disorders.
authors.affiliation: The Gladstone Institutes, University of California, San Francisco, California 94158; email: lisa.gunaydin@ucsf.edu , akreitzer@gladstone.ucsf.edu.|Affiliation as of March 1, 2016: Department of Psychiatry and the Institute for Neurodegenerative Diseases, University of California, San Francisco, California 94158.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Gunaydin
authors.affiliation: The Gladstone Institutes, University of California, San Francisco, California 94158; email: lisa.gunaydin@ucsf.edu , akreitzer@gladstone.ucsf.edu.|Departments of Physiology and Neurology, University of California, San Francisco, California 94143.
authors.forename: Anatol C
authors.initials: AC
authors.lastname: Kreitzer
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000503:physiopathology*; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology*
keywords: anxiety; depression; obsessive-compulsive disorder; prefrontal cortex; striatum