title: Comparative study of two doses of intrathecal dexmedetomidine as adjuvant with low dose hyperbaric bupivacaine in ambulatory perianal surgeries: A prospective randomised controlled study.
abstract: OBJECTIVE
  Dexmedetomidine (DMT), as intrathecal adjuvant has been shown to successfully prolong duration of analgesia but delay the motor recovery. Hence, this study was designed to find out the dose of DMT which can provide satisfactory analgesia without prolonging motor block.
  
  
  METHODS
  A total of 50 patients scheduled for elective perianal surgeries were randomly allocated to Groups C or D (n = 25). Group D received hyperbaric bupivacaine 0.5% 4 mg + DMT 5 μg and Group C received hyperbaric bupivacaine 0.5% 4 mg + DMT 3 μg intrathecally. Onset and duration of sensory and motor blockade, duration of analgesia, time for ambulation and first urination were recorded. Adverse effects if any were noted.
  
  
  RESULTS
  Demographic characters, duration of surgery were comparable. The onset of sensory block to S1 was 9.61 ± 5.53 min in Group C compared to 7.69 ± 4.80 min in Group D (P = 0.35). Duration of sensory (145.28 ± 83.17 min - C, 167.85 ± 93.75 min - D, P = 0.5) and motor block (170.53 ± 73.44 min - C, 196.14 ± 84.28 min, P = 0.39) were comparable. Duration of analgesia (337.86 ± 105.11 min - C, 340.78 ± 101.81 min - D, P = 0.9) and time for ambulation (252.46 ± 93.72 min - C, 253.64 ± 88.04 min - D, P = 0.97) were also comparable. One patient in each group had urinary retention requiring catheterization. No other side effects were observed.
  
  
  CONCLUSIONS
  Intrathecal DMT 3 μg dose does not produce faster ambulation compared to intrathecal DMT 5 μg though it produces comparable duration of analgesia for perianal surgeries.
authors.affiliation: Department of Anaesthesiology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.
authors.forename: K
authors.initials: K
authors.lastname: Sudheesh
authors.affiliation: Department of Anaesthesiology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.
authors.forename: Rs Raghavendra
authors.initials: RR
authors.lastname: Rao
authors.affiliation: Department of Anaesthesiology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.
authors.forename: M
authors.initials: M
authors.lastname: Kavya
authors.affiliation: Department of Anaesthesiology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.
authors.forename: J
authors.initials: J
authors.lastname: Aarthi
authors.affiliation: Department of Anaesthesiology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.
authors.forename: D Devika
authors.initials: DD
authors.lastname: Rani
authors.affiliation: Department of Anaesthesiology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.
authors.forename: S S
authors.initials: SS
authors.lastname: Nethra
keywords: Ambulatory; dexmedetomidine; intrathecal; motor block; perianal surgeries