title: Status of Dyslipidemia in Vitamin D Supplemented Argentinean Indigenous Children Versus A Non-supplemented Mixed Population Group.
abstract: BACKGROUND
  Epidemiological studies have suggested an inverse association between circulating levels of vitamin D and cardiovascular disease risk biomarkers, including an atherogenic lipid profile.
  
  
  OBJECTIVE
  To compare the prevalence and the distribution of lipid levels among vitamin D supplemented Argentinean indigenous San Antonio de los Cobres (SAC) children with a nonsupplemented Buenos Aires (BA) mixed population group.
  
  
  METHODS
  A group of indigenous children from SAC with hypovitaminosis D supplemented with vitamin D; and a nonsupplemented group from a BA mixed population were compared via a cross sectional study. Anthropometric measures, glucose, lipids, vitamin D, and insulin were measured.
  
  
  RESULTS
  The mean ages were 10.3 + 2.3 in SAC and 8.7 ± 1.8 years in BA children. There was a lower prevalence of overweight 7.9%(15/192) vs 17.8% (23/129); and of obesity 1.6% (3/192) vs 30.2% (39/129) in SAC vs. BA respectively. Approximately half of the SAC children versus 30% from BA had optimal vitamin D levels (≥30ng/mL). There was a significantly higher prevalence of high triglycerides (TG) (27.6%vs 4.6%) and low HDL-C (21.3% vs 5.4%) in SAC vs BA children, respectively. In separate linear regression models, we found that despite effective vitamin D repletion, SAC children had higher TG and TG/HDL-C values, whereas HDL-C levels were lower than those of BA children adjusted for age, gender, BMI, and insulin levels.
  
  
  CONCLUSIONS
  Indigenous Argentinean children have a higher risk for dyslipidemia in comparison with BA children, even after vitamin D treatment, suggesting that dyslipidemia could be related to diet or ethnic backgrounds.
authors.affiliation: From the University of Buenos Aires, Argentina, Maipu 812 5 M Buenos Aires (1006), Argentina. vhirschler@intramed.net.
authors.forename: Valeria
authors.initials: V
authors.lastname: Hirschler
authors.forename: Claudia
authors.initials: C
authors.lastname: Molinari
authors.forename: Gustavo
authors.initials: G
authors.lastname: Maccallini
authors.forename: Milva
authors.initials: M
authors.lastname: Sanchez
authors.forename: Claudio
authors.initials: C
authors.lastname: Gonzalez
authors.lastname: On Behalf Of San Antonio de Los Cobres Study Group Collaborators Graciela Colque
authors.forename: Mariana
authors.initials: M
authors.lastname: Hidalgo
authors.forename: Marcelo
authors.initials: M
authors.lastname: Figueroa
authors.forename: Claudio
authors.initials: C
authors.lastname: Adranda
authors.affiliation: From the University of Buenos Aires, Argentina, Maipu 812 5 M Buenos Aires (1006), Argentina. vhirschler@intramed.net.
authors.forename: Luis
authors.initials: L
authors.lastname: Castanno
mesh_terms: D001118:Argentina; D002648:Child; D019587:Dietary Supplements; D050171:Dyslipidemias / Q000208:ethnology / Q000628:therapy*; D006801:Humans; D044382:Population Groups; D012044:Regression Analysis; D013020:South America; D014807:Vitamin D / Q000097:blood
chemical_list: D014807:Vitamin D