title: [Association of VEGFR2 gene polymorphisms with the effect of L-dopa and dyskinesia complications].
abstract: OBJECTIVE
  To explore the association of VEGFR2 gene polymorphisms (rs2305948 and rs1870377) with the effect of levodopa (L-dopa) and dyskinesia in Chinese population and to provide theoretical basis for clinical treatment.
  
  
  METHODS
  By using Taqman MGB analysis and gene sequencing, the rs2305948 and rs1870377 polymorphisms of 69 enrolled Parkinson's disease (PD) patients were detected. Among them, 32 cases developed dyskinesia during 5 years and 37 cases did not develop dyskinesia during 8 years (as the control).
  
  
  RESULTS
  There was no significant association between the occurrence of dyskinesia and VEGFR2 polymorphisms at rs2305948 and rs1870377. However, rs1870377 polymorphism of AA showed greater maximum L-dopa dose [(565.00±163.55) mg/d vs (396.88±200.39) mg/d, (300.00±80.18) mg/d, P=0.038] and higher value of Modified Abnormal Involuntary Movement Scale (mAIMS) compared with that with polymorphisms of AT and TT [17.00±5.24 vs 8.94±6.53, 7.86±4.45, P=0.026].
  
  
  CONCLUSIONS
  VEGFR2 genes polymorphism (rs1870377) is associated with maximum L-dopa dose and mAIMS value in PD patients.
authors.affiliation: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Yuanliang
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Long
authors.initials: L
authors.lastname: Qian
authors.affiliation: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Fang
authors.affiliation: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Zhicheng
authors.initials: Z
authors.lastname: Gong
mesh_terms: D000978:Antiparkinson Agents / Q000494:pharmacology*; D006801:Humans; D007980:Levodopa / Q000494:pharmacology*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000235:genetics; D011110:Polymorphism, Genetic; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000235:genetics*
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa; D040301:Vascular Endothelial Growth Factor Receptor-2