title: Molecular epidemiology of enteric viruses in patients with acute gastroenteritis in Aichi prefecture, Japan, 2008/09-2013/14.
abstract: Acute gastroenteritis is a critical infectious disease that affects infants and young children throughout the world, including Japan. This retrospective study was conducted from September 2008 to August 2014 (six seasons: 2008/09-2013/14) to investigate the incidence of enteric viruses responsible for 1,871 cases of acute gastroenteritis in Aichi prefecture, Japan. Of the 1,871 cases, 1,100 enteric viruses were detected in 978 samples, of which strains from norovirus (NoV) genogroup II (60.9%) were the most commonly detected, followed by strains of rotavirus A (RVA) (23.2%), adenovirus (AdV) type 41 (8.2%), sapovirus (SaV) (3.6%), human astrovirus (HAstV) (2.8%), and NoV genogroup I (1.3%). Sequencing of the NoV genogroup II (GII) strains revealed that GII.4 was the most common genotype, although four different GII.4 variants were also identified. The most common G-genotype of RVA was G1 (63.9%), followed by G3 (27.1%), G2 (4.7%) and G9 (4.3%). Three genogroups of SaV strains were found: GI (80.0%), GII (15.0%), and GV (5.0%). HAstV strains were genotyped as HAstV-1 (80.6%), HAstV-8 (16.1%), and HAstV-3 (3.2%). These results show that NoV GII was the leading cause of sporadic acute viral gastroenteritis, although a variety of enteric viruses were detected during the six-season surveillance period.
authors.affiliation: Aichi Prefectural Institute of Public Health, Nagoya, Aichi, Japan.|Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.|Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Aichi, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Nakamura
authors.affiliation: Aichi Prefectural Institute of Public Health, Nagoya, Aichi, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kobayashi
authors.affiliation: Aichi Prefectural Institute of Public Health, Nagoya, Aichi, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Minagawa
authors.affiliation: Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsushita
authors.affiliation: Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.|Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Aichi, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Sugiura
authors.affiliation: Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.|Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Aichi, Japan.
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Iwatani
mesh_terms: D000208:Acute Disease / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019350:Astroviridae Infections / Q000453:epidemiology* / Q000821:virology; D017250:Caliciviridae Infections / Q000453:epidemiology* / Q000821:virology; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000821:virology; D005243:Feces / Q000821:virology; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology*; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D008297:Male; D001257:Mamastrovirus / Q000235:genetics* / Q000302:isolation & purification; D008875:Middle Aged; D017720:Molecular Epidemiology; D029322:Norovirus / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D012189:Retrospective Studies; D012401:Rotavirus / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000821:virology; D029341:Sapovirus / Q000235:genetics* / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D012367:RNA, Viral
keywords: acute gastroenteritis; enteric viruses; molecular epidemiology; norovirus; pediatric