title: Catalytic asymmetric conjugate addition of isocyanoacetate to (Z)-3-substituted-2-(4-pyridyl)-acrylonitrile, a reactive class of Michael acceptor.
abstract: (Z)-3-Substituted-2-(4-pyridyl)-acrylonitriles, a reactive class of Michael acceptors obtained exclusively as a single (Z) isomer, reacted with un-substituted isocyanoacetate esters mediated by phase-transfer catalysis to give, after base promoted cyclisation, functionalized imines in up to 94% ee and as a single diastereoisomer.
authors.affiliation: Centre for Synthesis and Chemical Biology (CSCB), Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland. madamo@rcsi.ie.
authors.forename: Claudia
authors.initials: C
authors.lastname: Del Fiandra
authors.forename: Maria
authors.initials: M
authors.lastname: Moccia
authors.forename: Valentina
authors.initials: V
authors.lastname: Cerulli
authors.forename: Mauro F A
authors.initials: MF
authors.lastname: Adamo