title: Preparation, characterization and in vitro dissolution behavior of porous biphasic α/β-tricalcium phosphate bioceramics.
abstract: The ideal bone tissue engineering scaffolds are long-cherished with the properties of interconnected macroporous structures, adjustable degradation and excellent biocompatibility. Here, a series of porous α/β-tricalcium phosphate (α/β-TCP) biphasic bioceramics with different phase ratios of α-TCP and β-TCP were successfully synthesized by heating an amorphous calcium phosphate precursor. The chemical and morphological characterization showed that α- and β-TCP phases co-existed in the α/β-TCP bioceramics and they had interconnected pore structures with size between 200 and 500μm. The in vitro dissolution behavior and bioactivity of the dual α/β-TCP were also probed in static and dynamic SBF for the first time. The results revealed that α/β-TCP scaffolds had good in vitro bioactivity, as the formation of bone-like apatite layers was induced on the scaffolds after mineralization in SBF. Moreover, dissolution rate of α/β-TCP bioceramics in dynamic environment was higher than that under static condition. Compared with monophasic TCP ceramics, these porous α/β-TCP bioceramics displayed a tailored dissolution rate proportionate to the TCP content (α and β) in the materials. Further, the degradation profile of porous α/β-TCP was well-described by Avrami equation. The porous dual α/β-TCP bioceramics with controllable degradation behavior hold great potential to be applied in bone tissue engineering as bone substitutes.
authors.affiliation: State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu 610065, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Xie
authors.affiliation: State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu 610065, China. Electronic address: yhyang6812@scu.edu.cn.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Yu
authors.affiliation: School of Chemical Engineering, Sichuan University, Chengdu 610065, China; Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. Electronic address: dengyibandeng@pku.edu.cn.
authors.forename: Yi
authors.initials: Y
authors.lastname: Deng
authors.affiliation: School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Weizhong
authors.initials: W
authors.lastname: Yang
authors.affiliation: School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liao
authors.affiliation: School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Long
mesh_terms: D018786:Bone Substitutes / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate
keywords: Bioceramic; Bone tissue engineering; Dissolution; Porous; α/β-tricalcium phosphate