title: Association of CX3CR1 (V249I and T280M) polymorphisms with age-related macular degeneration: a meta-analysis.
abstract: OBJECTIVE
  Studies investigating the associations between CX3CR1 genetic polymorphisms and age-related macular degeneration (AMD) have reported controversial results. Therefore, this meta-analysis aims to clarify the effects of CX3CR1 T280M and V249I polymorphisms on AMD risk.
  
  
  METHODS
  Meta-analysis.
  
  
  METHODS
  Results from six studies were pooled in the meta-analysis.
  
  
  METHODS
  Relevant studies were selected through an extensive search of PubMed, EMBASE, and the Web of Science databases. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random-effects model.
  
  
  RESULTS
  Six studies with were included in this systematic review and meta-analysis. There was no significant association between CX3CR1 T280M polymorphism and risk of AMD under all genetic models (TT vs
  OR = 1.57, 95% CI = 0.87-2.84; CC vs TT/CT: OR = 0.75, 95% CI = 0.54-1.06; TT vs CC: OR = 0.58, 95% CI = 0.30-1.144; CT vs CC: OR = 1.25, 95% CI = 0.91-1.70). The CX3CR1 V249I polymorphism also did not significantly affect the AMD risk (AA vs
  OR = 1.23, 95% CI = 0.98-1.55; AG/AA vs GG: OR = 0.56, 95% CI = 0.29-1.07; AA vs GG: OR = 1.43, 95% CI = 0.97-2.09; AG vs GG: OR = 1.07, 95% CI = 0.85-1.36).
  
  
  CONCLUSIONS
  This meta-analysis suggested that CX3CR1 T280M and V249I polymorphisms may not be associated with an increased risk of AMD based on current published data. Given the limited sample size, the finding on CX3CR1 polymorphisms needs further investigation.
authors.affiliation: Department of Ophthalmology, Beijing Di Tan Hospital, Capital Medical University, Beijing, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.affiliation: Beijng Tongren Eye Center, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing Tongren Hospital.
authors.forename: XiaoYan
authors.initials: X
authors.lastname: Peng
authors.affiliation: Department of Ophthalmology, Beijing Di Tan Hospital, Capital Medical University, Beijing, China. Electronic address: sunhuiyu123@126.com.
authors.forename: HuiYu
authors.initials: H
authors.lastname: Sun
mesh_terms: D000483:Alleles; D000073883:CX3C Chemokine Receptor 1; D016208:Databases, Factual; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008268:Macular Degeneration / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D019707:Receptors, Chemokine / Q000235:genetics*; D012307:Risk Factors
chemical_list: D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D019707:Receptors, Chemokine