title: Association of single-nucleotide polymorphisms rs2197076 and rs2241883 of FABP1 gene with polycystic ovary syndrome.
abstract: OBJECTIVE
  The objective of this study was to evaluate the association between single-nucleotide polymorphisms (SNPs) rs2197076 and rs2241883 in fatty acid-binding protein 1 (FABP1) gene and polycystic ovary syndrome (PCOS).
  
  
  METHODS
  The two alleles rs2197076 and rs2241883 in FABP1 gene in 221 PCOS women and 198 normal women were amplified and sequenced. Allele frequency comparison was performed between the PCOS and control groups, and genotype-phenotype correlation analysis was performed using dominant and recessive models to assess the association of FABP1 and the main features of PCOS.
  
  
  RESULTS
  Allele frequency analyses showed a strong association of SNPs rs2197076 and rs2241883 of FABP1 gene with PCOS (P < 0.001). The additive, dominant, and recessive genotype model analyses further supported this association even after adjusting for age and body mass index (BMI). The minor allele frequency (MAF) of rs2241883 in obese PCOS women was less than that in obese control women. Further genotype-phenotype correlation analysis showed that SNP rs2197076 had a stronger association with the main features of PCOS than SNP rs2241883.
  
  
  CONCLUSIONS
  In the association of SNPs in FABP1 gene with PCOS, rs2197076 was more closely associated with its main features than rs2241883 and seemed to play a more important role in the pathogenesis of PCOS.
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital affiliated to Shandong University, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan, 250021, China.|Department of Reproductive Medicine, Rizhao City Hospital of Traditional Chinese Medicine, Rizhao, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.|The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China.
authors.forename: Hongxi
authors.initials: H
authors.lastname: Xue
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital affiliated to Shandong University, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan, 250021, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.|The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China.
authors.forename: Han
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital affiliated to Shandong University, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan, 250021, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.|The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital affiliated to Shandong University, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan, 250021, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.|The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China.
authors.forename: Yue-ran
authors.initials: YR
authors.lastname: Zhao
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital affiliated to Shandong University, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan, 250021, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.|The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China.
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Chen
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital affiliated to Shandong University, Shandong Provincial Key Laboratory of Reproductive Medicine, 324 Jingwu Road, Jinan, 250021, China. jf1985jchj@163.com.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China. jf1985jchj@163.com.|The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China. jf1985jchj@163.com.
authors.forename: Jinlong
authors.initials: J
authors.lastname: Ma
mesh_terms: D000328:Adult; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide
chemical_list: C493319:FABP1 protein, human; D050556:Fatty Acid-Binding Proteins
keywords: FABP1 gene; Lipid metabolism; Liver fatty acid-binding protein; PCOS; Polycystic ovary syndrome; SNP