title: Layer by layer assembly of albumin nanoparticles with selective recognition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
abstract: Crosslinked albumin nanoparticles which loaded with doxorubicin (DOX) were fabricated with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and biocompatible polysaccharide, alginate (ALG), using layer-by-layer technique. Albumin nanoparticles exhibited narrow size distribution and fluorescent property. The assembled core/shell structure of the nanoparticles can be internalized more easily with the cancer cells, which attributes to TRAIL binding with death receptors. TRAIL still hold bioactive properties after assembled onto the particles. In addition, after loaded into the albumin core nanoparticles, DOX (as the chemotherapeutics) display a synergistic cytotoxic effect on cytotoxicity in combination with TRAIL in vitro. The core/shell nanostructured nanoparticles realized in this study would be used as a promising candidate for novel drug carriers.
authors.affiliation: Beijing National Laboratory for Molecule Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, ZhongGuanCun North First Street 2, 100190 Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.affiliation: National Centre for Nanoscience and Technology, Beijing 100190, China.
authors.forename: Anhe
authors.initials: A
authors.lastname: Wang
authors.affiliation: Beijing National Laboratory for Molecule Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, ZhongGuanCun North First Street 2, 100190 Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Beijing National Laboratory for Molecule Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, ZhongGuanCun North First Street 2, 100190 Beijing, China.
authors.forename: Xiaoke
authors.initials: X
authors.lastname: Yang
authors.affiliation: Beijing National Laboratory for Molecule Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, ZhongGuanCun North First Street 2, 100190 Beijing, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Cai
authors.affiliation: Beijing National Laboratory for Molecule Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, ZhongGuanCun North First Street 2, 100190 Beijing, China; National Centre for Nanoscience and Technology, Beijing 100190, China. Electronic address: jbli@iccas.ac.cn.
authors.forename: Junbai
authors.initials: J
authors.lastname: Li
mesh_terms: D000418:Albumins / Q000737:chemistry / Q000494:pharmacology; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000737:chemistry*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000418:Albumins; D004337:Drug Carriers; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D004317:Doxorubicin
keywords: Albumin; Core–shell; Layer-by-layer; Nanoparticles; TRAIL