title: Improving therapeutic effectiveness and safety through big healthcare data.
abstract: Big healthcare data-electronically recorded longitudinal data generated during the provision and administration of healthcare for millions of patients-have become essential for understanding the effectiveness and safety of therapeutics. They are most effectively used in concert with experimental and laboratory research throughout the life cycle of a drug. Applications range from providing phenotype and health outcomes information in genome-wide association studies to postmarketing studies that assure prescribers of the safety of approved drugs (Figure ). [Figure: see text].
authors.affiliation: Division of Pharmacoepidemiology, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: S
authors.initials: S
authors.lastname: Schneeweiss
mesh_terms: D016208:Databases, Factual; D003695:Delivery of Health Care / Q000706:statistics & numerical data*; D006801:Humans; D011358:Product Surveillance, Postmarketing; D016896:Treatment Outcome