title: GPR55 - a putative "type 3" cannabinoid receptor in inflammation.
abstract: G protein-coupled receptor 55 (GPR55) shares numerous cannabinoid ligands with CB1 and CB2 receptors despite low homology with those classical cannabinoid receptors. The pharmacology of GPR55 is not yet fully elucidated; however, GPR55 utilizes a different signaling system and downstream cascade associated with the receptor. Therefore, GPR55 has emerged as a putative "type 3" cannabinoid receptor, establishing a novel class of cannabinoid receptor. Furthermore, the recent evidence of GPR55-CB1 and GPR55-CB2 heteromerization along with its broad distribution from central nervous system to peripheries suggests the importance of GPR55 in various cellular processes and pathologies and as a potential therapeutic target in inflammation.
authors.forename: Hyewon
authors.initials: H
authors.lastname: Yang
authors.forename: Juan
authors.initials: J
authors.lastname: Zhou
authors.forename: Christian
authors.initials: C
authors.lastname: Lehmann
mesh_terms: D000818:Animals; D002186:Cannabinoids / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D043882:Receptors, Cannabinoid / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D002186:Cannabinoids; D043882:Receptors, Cannabinoid; D043562:Receptors, G-Protein-Coupled