title: The Effects of Quercetin on Acute Lung Injury and Biomarkers of Inflammation and Oxidative Stress in the Rat Model of Sepsis.
abstract: Experimental studies indicate that sepsis causes remote organ injury although the molecular mechanism has not been clearly defined. In this report, the role of oxidative damage, and inflammation on lung injury, following sepsis model by cecal ligation and puncture, and the effects of quercetin, antioxidant, and anti-inflammatory flavonoid, in the lung tissue were investigated. In the present study, we found that administration of single-dose quercetin before cecal ligation and puncture procedure, while markedly diminishing the levels of YKL-40 and oxidant molecules (xanthine oxidase (XO), nitric oxide (NO), and malondialdehyde (MDA)), increases the antioxidant enzymes levels. Quercetin is beneficial to acute lung injury by decreasing the levels of oxidative stress markers and increasing the antioxidant enzyme activities. Quercetin also causes a decrease in the serum levels of YKL-40 and periostin in the oxidative lung injury induced by the experimental sepsis model.
authors.affiliation: Department of Biochemistry, Medical Faculty, Namik Kemal University, Namık Kemal Mahallesi Kampus Caddesi No:1, 59100, Merkez-Tekirdag, Turkey. drfgerin@yahoo.com.
authors.forename: Fethullah
authors.initials: F
authors.lastname: Gerin
authors.affiliation: Department of Physiology, Namik Kemal University, Tekirdag, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Sener
authors.affiliation: Department of Biochemistry, Medical Faculty, Namik Kemal University, Namık Kemal Mahallesi Kampus Caddesi No:1, 59100, Merkez-Tekirdag, Turkey.
authors.forename: Hayriye
authors.initials: H
authors.lastname: Erman
authors.affiliation: Department of Biochemistry, Medical Faculty, Namik Kemal University, Namık Kemal Mahallesi Kampus Caddesi No:1, 59100, Merkez-Tekirdag, Turkey.
authors.forename: Ahsen
authors.initials: A
authors.lastname: Yilmaz
authors.affiliation: Department of Biochemistry, Medical Faculty, Namik Kemal University, Namık Kemal Mahallesi Kampus Caddesi No:1, 59100, Merkez-Tekirdag, Turkey.
authors.forename: Bayram
authors.initials: B
authors.lastname: Aydin
authors.affiliation: Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Ferah
authors.initials: F
authors.lastname: Armutcu
authors.affiliation: Department of Biochemistry, Medical Faculty, Namik Kemal University, Namık Kemal Mahallesi Kampus Caddesi No:1, 59100, Merkez-Tekirdag, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gurel
mesh_terms: D055371:Acute Lung Injury / Q000188:drug therapy*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D002432:Cecum / Q000601:surgery; D015815:Cell Adhesion Molecules / Q000097:blood*; D000071451:Chitinase-3-Like Protein 1 / Q000097:blood* / Q000378:metabolism; D004195:Disease Models, Animal; D007249:Inflammation / Q000188:drug therapy; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D011794:Quercetin / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000473:pathology*; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; C507621:CHI3L1 protein, rat; D015815:Cell Adhesion Molecules; D000071451:Chitinase-3-Like Protein 1; C512836:Postn protein, rat; D009569:Nitric Oxide; D008315:Malondialdehyde; D011794:Quercetin; D014969:Xanthine Oxidase
keywords: YKL-40; oxidative stress; quercetin; sepsis