title: The effect of exercise training on the course of cardiac troponin T and I levels: three independent training studies.
abstract: With the introduction of high-sensitive assays, cardiac troponins became potential biomarkers for risk stratification and prognostic medicine. Observational studies have reported an inverse association between physical activity and basal cardiac troponin levels. However, causality has never been demonstrated. This study investigated whether basal cardiac troponin concentrations are receptive to lifestyle interventions such as exercise training. Basal high-sensitive cardiac troponin T (cTnT ) and I (cTnI) were monitored in two resistance-type exercise training programs (12-week (study 1) and 24-week (study 2)) in older adults (≥65 years). In addition, a retrospective analysis for high sensitive troponin I in a 24-week exercise controlled trial in (pre)frail older adults was performed (study 3). In total, 91 subjects were included in the final data analyses. There were no significant changes in cardiac troponin levels over time in study 1 and 2 (study 1: cTnT -0.13 (-0.33-+0.08) ng/L/12-weeks, cTnI -0.10 (-0.33-+0.12) ng/L/12-weeks; study 2: cTnT -1.99 (-4.79-+0.81) ng/L/24-weeks, cTnI -1.59 (-5.70-+2.51) ng/L/24-weeks). Neither was there a significant interaction between training and the course of cardiac troponin in study 3 (p = 0.27). In conclusion, this study provides no evidence that prolonged resistance-type exercise training can modulate basal cardiac troponin levels.
authors.affiliation: Department of Clinical Chemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, The Netherlands.
authors.forename: Noreen
authors.initials: N
authors.lastname: van der Linden
authors.affiliation: Department of Clinical Chemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, The Netherlands.
authors.forename: Lieke J J
authors.initials: LJ
authors.lastname: Klinkenberg
authors.affiliation: Department of Human Movement Sciences, School for Nutrition, Toxicology and Metabolism (NUTRIM), Maastricht University Medical Center (MUMC), Maastricht, The Netherlands.|Top Institute Food and Nutrition, Wageningen University, Wageningen, The Netherlands.
authors.forename: Marika
authors.initials: M
authors.lastname: Leenders
authors.affiliation: Top Institute Food and Nutrition, Wageningen University, Wageningen, The Netherlands.|Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
authors.forename: Michael
authors.initials: M
authors.lastname: Tieland
authors.affiliation: Department of Human Movement Sciences, School for Nutrition, Toxicology and Metabolism (NUTRIM), Maastricht University Medical Center (MUMC), Maastricht, The Netherlands.|Top Institute Food and Nutrition, Wageningen University, Wageningen, The Netherlands.
authors.forename: Lex B
authors.initials: LB
authors.lastname: Verdijk
authors.affiliation: Department of Clinical Chemistry, Gelre Ziekenhuizen, Apeldoorn, The Netherlands.
authors.forename: Marijke
authors.initials: M
authors.lastname: Niens
authors.affiliation: Department of Clinical Chemistry, Gelre Ziekenhuizen, Apeldoorn, The Netherlands.
authors.forename: Jeroen D E
authors.initials: JD
authors.lastname: van Suijlen
authors.affiliation: Top Institute Food and Nutrition, Wageningen University, Wageningen, The Netherlands.|Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
authors.forename: Lisette C P G M
authors.initials: LC
authors.lastname: de Groot
authors.affiliation: Department of Clinical Chemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, The Netherlands.
authors.forename: Otto
authors.initials: O
authors.lastname: Bekers
authors.affiliation: Department of Human Movement Sciences, School for Nutrition, Toxicology and Metabolism (NUTRIM), Maastricht University Medical Center (MUMC), Maastricht, The Netherlands.|Top Institute Food and Nutrition, Wageningen University, Wageningen, The Netherlands.
authors.forename: Luc J C
authors.initials: LJ
authors.lastname: van Loon
authors.affiliation: Department of Clinical Chemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, The Netherlands.
authors.forename: Marja P
authors.initials: MP
authors.lastname: van Dieijen-Visser
authors.affiliation: Department of Clinical Chemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC), Maastricht, The Netherlands.
authors.forename: Steven J R
authors.initials: SJ
authors.lastname: Meex
mesh_terms: D000328:Adult; D000368:Aged; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D013997:Time Factors; D019210:Troponin I / Q000097:blood*; D020107:Troponin T / Q000097:blood*
chemical_list: D019210:Troponin I; D020107:Troponin T