title: APOLIPOPROTEINS AND THEIR ASSOCIATION WITH CARDIOMETABOLIC RISK BIOMARKERS IN ADOLESCENTS.
abstract: BACKGROUND
  the apoB/apo A-I ratio has been reported as an important predictor of cardiovascular risk, being superior to lipids, lipoproteins and conventional lipid ratios.
  
  
  OBJECTIVE
  to investigate the association between apolipoproteins A-I and B, and the apolipoprotein B/apolipoprotein A-I ratio and cardiometabolic risk variables in adolescents.
  
  
  METHODS
  this was a cross-sectional study including 104 adolescents of public schools in Recife during the months of March/April, 2013. Sociodemographic, anthropometric, clinical and biochemical variables were analysed. The apolipoproteins were analysed via Immunoturbidimetry.
  
  
  RESULTS
  body mass index, waist circumference, waist circumference/height, triglycerides, cholesterol/HDL, and apolipoprotein B/apolipoprotein A-I declined with the progress of the percentile distribution of apolipoprotein A-I concentrations, while the HDL and apolipoprotein B increased between the first and last quartiles of the apolipoprotein A-I concentrations. Systolic blood pressure, body mass index, waist circumference, waist circumference/height, cholesterol, LDL, triglycerides, cholesterol/HDL, and LDL/HDL increased progressively in the quartile distribution of the concentrations of apolipoprotein B and apolipoprotein B/apolipoprotein A-I. Alfa-1-acid glycoprotein serum levels increased hand-inhand with the percentile progression of apolipoprotein B.
  
  
  CONCLUSIONS
  the findings underline an important association of apolipoproteins A-I and B, and the apolipoprotein B/apolipoprotein A-I ratio and their clinical, biochemical and anthropometric cardiometabolic risk. However, prospective studies are important to evaluate the pertinence of implementing these markers in the clinical practice.
authors.affiliation: Department of Nutrition. Federal University of Pernambuco, Recife, Brazil.. mellinaalbuquerque@yahoo.com.br.
authors.forename: Mellina
authors.initials: M
authors.lastname: Neyla de Lima Albuquerque
authors.affiliation: Department of Nutrition. Federal University of Pernambuco, Recife, Brazil.. mellinaalbuquerque@yahoo.com.br.
authors.forename: Alcides
authors.initials: A
authors.lastname: da Silva Diniz
authors.affiliation: Department of Nutrition. Federal University of Pernambuco, Recife, Brazil.. mellinaalbuquerque@yahoo.com.br.
authors.forename: Ilma
authors.initials: I
authors.lastname: Kruze Grande de Arruda
mesh_terms: D000293:Adolescent; D001053:Apolipoproteins / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D001938:Brazil / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology*; D002648:Child; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000097:blood* / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors; D012959:Socioeconomic Factors; D055815:Young Adult
chemical_list: D001053:Apolipoproteins; D015415:Biomarkers