title: (+)-Chenabinol (Revised NMR Data) and Two New Alkaloids from Berberis vulgaris and their Biological Activity.
abstract: A known alkaloid (+)-chenabinol (1) and two new secobisbenzylisoquinoline alkaloids were isolated by standard chromatographic methods from the root bark of Berberis vulgaris L. The structures of the new alkaloids, named berkristine (2) and verfilline (3), were established by spectroscopic (including 2D NMR), and HRMS (ESI) methods. The alkaloids were tested for their inhibition activity of human cholinesterases and prolyl oligopeptidase. Compound 1 inhibited human butyrylcholinesterase with an IC50 value of 44.8 ± 5.4 μM.
authors.forename: Zdenĕk
authors.initials: Z
authors.lastname: Novák
authors.forename: Anna
authors.initials: A
authors.lastname: Hošt'álková
authors.forename: Lubomír
authors.initials: L
authors.lastname: Opletal
authors.forename: Lucie
authors.initials: L
authors.lastname: Nováková
authors.forename: Martina
authors.initials: M
authors.lastname: Hrabinová
authors.forename: Jiří
authors.initials: J
authors.lastname: Kuneš
authors.forename: Lucie
authors.initials: L
authors.lastname: Cahlíková
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D028142:Berberis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; C000604461:chenabinol