title: [Half-molar sodium-lactate: The osmotic agent we are looking for?].
abstract: Intracranial hypertension (ICH) is the most important modifiable factor with predictive negative value in brain injury patients. Osmotherapy is the most important first level specific measure in the treatment of ICH. Mannitol 20%, and 3, 7.5, 10, and 23% hypertonic sodium chloride are the most commonly used osmotic agents in the neurocritical care setting. Currently, controversy about the best osmotic agent remains elusive. Therefore, over the past few years, half-molar sodium lactate has been introduced as a new osmotic agent to be administered in the critically ill. Lactate is able to prevent hyperchloremia, as well as its adverse effects such as hyperchloremic acidosis, systemic inflammation, and acute kidney injury. Furthermore, lactate may also be used by glia as energy substrate in brain injury patients. Half-molar sodium lactate would also have a more potent and long-lasting effect decreasing intracellular osmolarity and by inhibiting neuronal volume control mechanisms. Pioneering researches in patients with traumatic brain injury have shown a more significant effect than mannitol on the control of ICH. In addition, in this group of patients this solution appears to be beneficial in preventing episodes of ICH. However, future research is necessary to corroborate or not these promising results.
authors.affiliation: Cátedra de Medicina Intensiva, Centro de Tratamiento Intensivo, Hospital de Clínicas Dr. Manuel Quintela, Facultad de Medicina, Universidad de la República (UdeLaR), Montevideo, Uruguay. Electronic address: nachoaramendi@gmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Aramendi
authors.affiliation: Cátedra de Medicina Intensiva, Centro de Tratamiento Intensivo, Hospital de Clínicas Dr. Manuel Quintela, Facultad de Medicina, Universidad de la República (UdeLaR), Montevideo, Uruguay.
authors.forename: W
authors.initials: W
authors.lastname: Manzanares
authors.affiliation: Cátedra de Medicina Intensiva, Centro de Tratamiento Intensivo, Hospital de Clínicas Dr. Manuel Quintela, Facultad de Medicina, Universidad de la República (UdeLaR), Montevideo, Uruguay.
authors.forename: A
authors.initials: A
authors.lastname: Biestro
mesh_terms: D001930:Brain Injuries / Q000628:therapy*; D006801:Humans; D019586:Intracranial Hypertension / Q000628:therapy*; D008353:Mannitol; D012964:Sodium; D019354:Sodium Lactate
chemical_list: D008353:Mannitol; D012964:Sodium; D019354:Sodium Lactate
keywords: Hipertensión intracraneana; Intracranial hypertension; Lactato de sodio; Neurocritical care patient; Osmoterapia; Osmotherapy; Paciente neurocrítico; Sodium lactate