title: Psoriasis and uric acid: a population-based cross-sectional study.
abstract: BACKGROUND
  Psoriasis has been reported to be associated with raised serum uric acid levels and gout, and uric acid has been demonstrated to mediate inflammatory pathways via secretion of pro-inflammatory chemokines.
  
  
  OBJECTIVE
  To evaluate the association between psoriasis, serum uric acid levels and gout in a cross-sectional study using the US National Health and Nutrition Examination Survey (NHANES) database.
  
  
  METHODS
  Data on clinical history of psoriasis, gout and other relevant medical conditions from the questionnaire as well as laboratory parameters for serum uric acid and lipid levels in the periods 2003-2006 and 2011-2012 were analysed. Multivariate analysis with logistic regression modelling was performed, with hyperuricaemia as the dependent variable, and age, sex, ethnicity, body mass index, metabolic syndrome, current smoking status, alcohol consumption and history of psoriasis as the independent variables.
  
  
  RESULTS
  Of the 11 282 study participants, 297 (2.6%) reported a history of psoriasis and 1493 (13.2%) were found to have hyperuricaemia. Patients with psoriasis were at increased risk of having hyperuricaemia, compared with those without psoriasis (OR = 1.37; P = 0.04). They were also more likely to report a history of gout (OR = 1.83; P < 0.05). However, neither association was significant after adjusting for potential confounders with multivariate logistic regression.
  
  
  CONCLUSIONS
  In conclusion, there was insufficient evidence to show that psoriasis is an independent risk factor of hyperuricaemia or gout. A raised serum uric acid level may be a consequence of metabolic syndrome, which in turn is associated with psoriasis.
authors.affiliation: Harvard TH Chan School of Public Health, Boston, MA, USA.
authors.forename: Y C
authors.initials: YC
authors.lastname: Lai
authors.affiliation: Department of Dermatology, National Skin Centre, Singapore.
authors.forename: Y W
authors.initials: YW
authors.lastname: Yew
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006073:Gout / Q000097:blood; D006801:Humans; D033461:Hyperuricemia / Q000097:blood* / Q000209:etiology; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000150:complications; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid