title: Association of retinal thickness and optic disc-to-fovea angle to axial length of young healthy eyes.
abstract: OBJECTIVE
  To determine the relationship between the axial length (AL) and the retinal thickness in the posterior pole and to the optic disc-to-fovea (ODF) angle of healthy eyes.
  
  
  METHODS
  A prospective, observational cross-sectional study (registration number, UMIN000006040) of 64 healthy right eyes (mean age 26.0±4.5 years) was performed. The thickness of the 64 areas within the central 24° area were measured in the Spectralis spectral domain-optical coherent tomographic images obtained by posterior pole scans. Each area was 3°×3°. The ODF angle was measured in each fundus photograph. The relationships between the AL and the retinal thickness of each of the 64 areas and the ODF angle were investigated by linear regression analyses.
  
  
  RESULTS
  The mean AL was 25.0±1.3 mm and the mean ODF angle was 17.2°±1.0°. The average retinal thickness of the four areas around the fovea was constant and not significantly correlated with the AL. However, the retinal thicknesses of 54 of the other 60 areas were significantly and negatively correlated with the AL (R=-0.25 to -0.56, P<0.05). The ODF angle was also constant and not significantly correlated with the AL (R=-0.17, P=0.19).
  
  
  CONCLUSIONS
  The lack of significant correlations between the AL and the retinal thicknesses of the central 6° or the ODF angle suggests that there might be some feedback system to keep the central retinal thickness and ODF angle constant regardless of an elongation of the AL.
authors.affiliation: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Yamashita
authors.affiliation: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Taiji
authors.initials: T
authors.lastname: Sakamoto
authors.affiliation: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Terasaki
authors.affiliation: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Kii
authors.affiliation: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Eisuke
authors.initials: E
authors.lastname: Uchino
authors.affiliation: Department of Ophthalmology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Hisatomi
authors.affiliation: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Nakao
keywords: axial length; optic disc-to-fovea angle; retinal thickness