title: microRNA and Lung Cancer.
abstract: Lung cancer is the leading cause of cancer mortality worldwide. microRNAs (miRNAs) have been established as players with a relevant role in lung cancer development, epithelial-mesenchymal transition and response to therapy. Additionally, in the last decade, miRNAs, measured in resected tumor samples or in fine-needle aspirate samples have emerged as compelling biomarkers for tumor diagnosis, prognosis, and prediction of response to treatment, due to the ease of their detection and in their extreme specificity. Moreover, miRNAs present in sputum, in plasma, in serum or in whole-blood have increasingly been explored in the last 5 years as less invasive biomarkers for the early detection of cancers.
authors.affiliation: Laboratory of RNA Biology and Biotechnology, Centre for Integrative Biology, University of Trento, via Sommarive 9, Trento, 38123, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Del Vescovo
authors.affiliation: Laboratory of RNA Biology and Biotechnology, Centre for Integrative Biology, University of Trento, via Sommarive 9, Trento, 38123, Italy. michela.denti@unitn.it.
authors.forename: Michela A
authors.initials: MA
authors.lastname: Denti
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D011379:Prognosis; D013183:Sputum / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: Biomarker; Circulating miRNA; Diagnosis; Lung cancer; miRNA