title: Effect of genetic algorithm as a variable selection method on different chemometric models applied for the analysis of binary mixture of amoxicillin and flucloxacillin: A comparative study.
abstract: Different chemometric models were applied for the quantitative analysis of amoxicillin (AMX), and flucloxacillin (FLX) in their binary mixtures, namely, partial least squares (PLS), spectral residual augmented classical least squares (SRACLS), concentration residual augmented classical least squares (CRACLS) and artificial neural networks (ANNs). All methods were applied with and without variable selection procedure (genetic algorithm GA). The methods were used for the quantitative analysis of the drugs in laboratory prepared mixtures and real market sample via handling the UV spectral data. Robust and simpler models were obtained by applying GA. The proposed methods were found to be rapid, simple and required no preliminary separation steps.
authors.affiliation: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt.
authors.forename: Khalid A M
authors.initials: KA
authors.lastname: Attia
authors.affiliation: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt.
authors.forename: Mohammed W I
authors.initials: MW
authors.lastname: Nassar
authors.affiliation: Analytical Chemistry Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), 12582, Al Hadaba Al Wosta, Cairo, Egypt.
authors.forename: Mohamed B
authors.initials: MB
authors.lastname: El-Zeiny
authors.affiliation: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt. Electronic address: Ahmedserag777@hotmail.com.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Serag
mesh_terms: D000465:Algorithms; D000658:Amoxicillin / Q000032:analysis*; D000900:Anti-Bacterial Agents / Q000032:analysis*; D004304:Dosage Forms; D004338:Drug Combinations; D005436:Floxacillin / Q000032:analysis*; D016018:Least-Squares Analysis; D016571:Neural Networks, Computer; D013056:Spectrophotometry, Ultraviolet / Q000191:economics / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents; D004304:Dosage Forms; D004338:Drug Combinations; D005436:Floxacillin; D000658:Amoxicillin
keywords: ANN; Amoxicillin; CRACLS; Flucloxacillin; Genetic algorithm; SRACLS