title: Synthesis of glycosylphosphatidylinositol (GPI)-anchor glycolipids bearing unsaturated lipids.
abstract: 2-Naphthyl-methyl ethers as permanent protecting groups are readily removed under acidic conditions and are key to the synthesis of complex glycosylphosphatidylinositol anchors containing unsaturated lipids. The total synthesis of the GPI pseudo-disaccharide core found on the surface of the Trypanosoma cruzi parasite serves to illustrate the power of the strategy.
authors.affiliation: Max Planck Institute of Colloids and Interfaces, Biomolecular Systems, Am Mühlenberg 1, 14476 Potsdam, Germany. daniel.varon@mpikg.mpg.de.
authors.forename: B-Y
authors.initials: BY
authors.lastname: Lee
authors.forename: P H
authors.initials: PH
authors.lastname: Seeberger
authors.forename: D
authors.initials: D
authors.lastname: Varon Silva
mesh_terms: D006017:Glycolipids / Q000737:chemistry*; D017261:Glycosylphosphatidylinositols / Q000737:chemistry*
chemical_list: D006017:Glycolipids; D017261:Glycosylphosphatidylinositols