title: Disseminated fusariosis by Fusarium proliferatum in a patient with aplastic anaemia receiving primary posaconazole prophylaxis - case report and review of the literature.
abstract: Disseminated fusariosis is a life-threatening, invasive, opportunistic infection in immunocompromised patients, especially those with haematological malignancies. The prognosis is poor because these fungi are resistant to many of the available antifungal agents. We present a case of disseminated fusariosis caused by Fusarium proliferatum in a patient with severe aplastic anaemia complicated by a secondary infection of Aspergillus flavus, with a fatal outcome. We also review the documented Fusarium infections in immunocompromised hosts.
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.|Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors.forename: Dita
authors.initials: D
authors.lastname: Ricna
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.|Faculty of Medicine, Masaryk University, Brno, Czech Republic.|CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
authors.forename: Martina
authors.initials: M
authors.lastname: Lengerova
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.|Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors.forename: Martina
authors.initials: M
authors.lastname: Palackova
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.|Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors.forename: Marketa
authors.initials: M
authors.lastname: Hadrabova
authors.affiliation: Department of Clinical Microbiology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Iva
authors.initials: I
authors.lastname: Kocmanova
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.|Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors.forename: Barbora
authors.initials: B
authors.lastname: Weinbergerova
authors.affiliation: Department of Pathology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Pavlovsky
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Pavlina
authors.initials: P
authors.lastname: Volfova
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.|Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Bouchnerova
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.|Faculty of Medicine, Masaryk University, Brno, Czech Republic.|CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
authors.forename: Jiri
authors.initials: J
authors.lastname: Mayer
authors.affiliation: Department of Internal Medicine - Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.|Faculty of Medicine, Masaryk University, Brno, Czech Republic.|CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Racil
mesh_terms: D000741:Anemia, Aplastic / Q000150:complications*; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001228:Aspergillosis / Q000150:complications / Q000382:microbiology; D001231:Aspergillus flavus / Q000187:drug effects / Q000302:isolation & purification; D060085:Coinfection; D017809:Fatal Outcome; D060585:Fusariosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D005670:Fusarium / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D014230:Triazoles / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole
keywords: Fusarium proliferatum; PCR diagnostics; fusariosis; real-time PCR