title: [Risk factors associated with gastroduodenal lesions in a Douala referral hospital (Cameroon)].
abstract: BACKGROUND
  The causes of gastroduodenal lesions are multifactorial, and few studies have assessed the impact of each of these factors in Africa. The aim of this study was to identify factors associated with the occurrence of gastroduodenal lesions in Cameroon.
  
  
  METHODS
  This prospective, analytical study took place over a 5-month period in the endoscopy unit of the Douala General Hospital. Lifestyle, medical history, demographic, and clinical variables were collected. Infection with Helicobacter pylori was determined with a rapid urease (CLO) test. Multivariate regression was used to determine risk factors.
  
  
  RESULTS
  The study included 234 of 265 patients seen in the department over the study period. Gastroscopy was normal for 54.2% of the subjects. The prevalence of peptic ulcers was 17.1% and of inflammatory lesions 26.4%. Risk factors associated with a gastroduodenal lesion were: age greater than 60 years [OR age = 2.953; 95% CI: 1.399 to 6.231; p = 0.004], H. pylori infection [OR = 2.953; 95% CI: 1.399 to 6.231; p = 0.003] and regular NSAID use [OR = 0.912; 95% CI: 0.112 to 2.733; p = 0.044] either a month before the examination or over the long term.
  
  
  CONCLUSIONS
  Age greater than 60 years, NSAID consumption, and H. pylori infection are associated with the occurrence of gastroduodenal lesions.
authors.affiliation: Service de médecine interne de l'hôpital Général de Douala, BP 4856, 999 Douala, Cameroun, Faculté de médecine et des sciences pharmaceutiques, BP 2701, 999 Douala, Cameroun.
authors.forename: S A F
authors.initials: SA
authors.lastname: Eloumou Bagnaka
authors.affiliation: Service de médecine interne de l'hôpital Général de Douala, BP 4856, 999 Douala, Cameroun, Faculté de médecine et des sciences pharmaceutiques, BP 2701, 999 Douala, Cameroun, Faculté de médecine et des sciences biomédicales et Yaoundé, Cameroun.
authors.forename: H
authors.initials: H
authors.lastname: Luma Namme
authors.affiliation: Faculté de médecine et des sciences pharmaceutiques, BP 2701, 999 Douala, Cameroun, Faculté de médecine et des sciences biomédicales et Yaoundé, Cameroun, Service de gastro-entérologie de l'hôpital central de Yaoundé, Cameroun.
authors.forename: D
authors.initials: D
authors.lastname: Noah Noah
authors.affiliation: Faculté de médecine et des sciences pharmaceutiques, BP 2701, 999 Douala, Cameroun.
authors.forename: N E
authors.initials: NE
authors.lastname: Essomba
authors.affiliation: Service de médecine interne de l'hôpital Général de Douala, BP 4856, 999 Douala, Cameroun.
authors.forename: A
authors.initials: A
authors.lastname: Malongue
authors.affiliation: Service de médecine interne de l'hôpital Général de Douala, BP 4856, 999 Douala, Cameroun.
authors.forename: A
authors.initials: A
authors.lastname: Manga
authors.affiliation: Faculté de médecine et des sciences pharmaceutiques, BP 2701, 999 Douala, Cameroun.
authors.forename: C
authors.initials: C
authors.lastname: Tzeuton
authors.affiliation: Faculté de médecine et des sciences biomédicales et Yaoundé, Cameroun.
authors.forename: M
authors.initials: M
authors.lastname: Biwole Sida
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002163:Cameroon; D004378:Duodenal Diseases / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012017:Referral and Consultation; D012307:Risk Factors; D013272:Stomach Diseases / Q000150:complications / Q000453:epidemiology*; D055815:Young Adult
keywords: Cameroon; Helicobacter pylori; endoscopy; gastroduodenal lesions; peptic ulcer