title: Reduction of microalbuminuria in type-2 diabetes mellitus with angiotensin-converting enzyme inhibitor alone and with cilnidipine.
abstract: The aim of our study was to find out the antiproteinuric effect of enalapril angiotensin-converting enzyme (ACE inhibitor) alone or in combination with cilnidipine in patients with type-2 diabetes mellitus. The study was conducted on 71 patients with type-2 diabetes mellitus patients with hypertension and microalbuminuria. They were divided into two groups randomly as follows: Group I (enalaprilalone, n = 36) and Group II (enalapril with cilnidipine, n = 35). In both the groups, baseline 24 h urinary albumin was estimated and was repeated every 3 months upto 1-year. After 1-year follow-up, reduction in microalbuminuria was found to be greater in Group II. In Group I microalbuminuria came down by 25.68 ± 21.40 while in Group II it reduced by 54.88 ± 13.84 (P < 0.001). We conclude that in diabetic population, cilnidipine has an additive effect in microalbuminuria reduction over and above the well-proven effect of ACE inhibitors.
authors.affiliation: Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: V K
authors.initials: VK
authors.lastname: Singh
authors.affiliation: Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: A
authors.initials: A
authors.lastname: Mishra
authors.affiliation: Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: K K
authors.initials: KK
authors.lastname: Gupta
authors.affiliation: Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: R
authors.initials: R
authors.lastname: Misra
authors.affiliation: Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: M L
authors.initials: ML
authors.lastname: Patel
authors.affiliation: Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.
authors.lastname: Shilpa
keywords: Angiotensin-converting enzyme inhibitors; diabetic nephropathy; microalbuminuria