title: The Ireland-Claisen rearrangement strategy towards the synthesis of the schizophrenia drug, (+)-asenapine.
abstract: (±)-Asenapine, sold in the market as Saphris/Sycrest for the treatment of bipolar disorders, is synthesized in an optically pure form involving an Ireland-Claisen rearrangement as the key step. This approach allows access to all diastereomers.
authors.affiliation: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, India 500 007. srivaric@iict.res.in.
authors.forename: Raghunath Reddy
authors.initials: RR
authors.lastname: Anugu
authors.forename: Prathama S
authors.initials: PS
authors.lastname: Mainkar
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Sridhar
authors.forename: Srivari
authors.initials: S
authors.lastname: Chandrasekhar
mesh_terms: D014150:Antipsychotic Agents / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D003986:Dibenzocycloheptenes; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D012559:Schizophrenia / Q000188:drug therapy*; D013237:Stereoisomerism
chemical_list: D014150:Antipsychotic Agents; D003986:Dibenzocycloheptenes; D006576:Heterocyclic Compounds, 4 or More Rings; C522667:asenapine