title: The role of margins in extremity soft tissue sarcoma.
abstract: For extremity soft tissue sarcomas, limb salvage is now standard of care. The extent of surgical margins is balanced with functionality of the resected limb. Although negative margins are the goal, the necessary width is unclear. Additional considerations for margin adequacy include presence of anatomic barriers such as fascia and periosteum, proximity of critical structures, receipt of adjuvant and neoadjuvant therapies, and histologic subtype. Multidisciplinary team discussion is critical for treatment planning.
authors.affiliation: Department of Surgery, Section of Surgical Oncology, Keck School of Medicine, University of Southern California, Los Angeles, California.
authors.forename: Saskya
authors.initials: S
authors.lastname: Byerly
authors.affiliation: Department of Surgery, Section of Surgical Oncology, Keck School of Medicine, University of Southern California, Los Angeles, California.
authors.forename: Shefali
authors.initials: S
authors.lastname: Chopra
authors.affiliation: Sarcoma Program, Hoag Memorial Hospital Presbyterian, Newport Beach, California.
authors.forename: Nader A
authors.initials: NA
authors.lastname: Nassif
authors.affiliation: Sarcoma Program, Hoag Memorial Hospital Presbyterian, Newport Beach, California.
authors.forename: Peter
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Surgery, Section of Surgical Oncology, Keck School of Medicine, University of Southern California, Los Angeles, California.
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Sener
authors.affiliation: Sarcoma Program, Hoag Memorial Hospital Presbyterian, Newport Beach, California.
authors.forename: Burton L
authors.initials: BL
authors.lastname: Eisenberg
authors.affiliation: Department of Surgery, Section of Surgical Oncology, Keck School of Medicine, University of Southern California, Los Angeles, California.|Sarcoma Program, Hoag Memorial Hospital Presbyterian, Newport Beach, California.
authors.forename: William W
authors.initials: WW
authors.lastname: Tseng
mesh_terms: D005121:Extremities / Q000473:pathology / Q000601:surgery; D006801:Humans; D023821:Limb Salvage; D020360:Neoadjuvant Therapy / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D018365:Neoplasm, Residual / Q000517:prevention & control; D012509:Sarcoma / Q000473:pathology / Q000517:prevention & control* / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000517:prevention & control* / Q000601:surgery*; D013514:Surgical Procedures, Operative / Q000379:methods / Q000592:standards
keywords: extremity; margins; soft tissue sarcoma