title: The importance of surgical margins in primary malignancies of the liver.
abstract: Resection is an important treatment modality for hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Anatomic resection is generally preferred for HCC. When anatomic resection is not feasible, prospective data have demonstrated an improved outcome among HCC patients who have a resection with wide versus narrow surgical margins. Similarly, among patients with ICC, R1 resection has been associated with worse outcomes. In addition, margin width may also impact risk of recurrence and survival. As such, provided adequate functional liver remnant remains, anatomic resection with wide margins is recommended for HCC and ICC.
authors.affiliation: Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
authors.forename: Kelly
authors.initials: K
authors.lastname: Lafaro
authors.affiliation: Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
authors.forename: Miral Sadaria
authors.initials: MS
authors.lastname: Grandhi
authors.affiliation: Department of Radiation Oncology, Johns Hopkins Hospital, Baltimore, Maryland.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Herman
authors.affiliation: Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Pawlik
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000517:prevention & control / Q000601:surgery*; D018281:Cholangiocarcinoma / Q000473:pathology / Q000517:prevention & control / Q000601:surgery*; D006498:Hepatectomy / Q000379:methods* / Q000592:standards*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000473:pathology / Q000517:prevention & control / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D018365:Neoplasm, Residual / Q000517:prevention & control; D011169:Portal Vein / Q000601:surgery*; D014656:Vascular Surgical Procedures / Q000592:standards
keywords: hepatocellular carcinoma; intrahepatic cholangiocarcinoma; liver cancer; surgical margins