title: Dynamics of low and high pathogenic avian influenza in wild and domestic bird populations.
abstract: This paper introduces a time-since-recovery structured, multi-strain, multi-population model of avian influenza. Influenza A viruses infect many species of wild and domestic birds and are classified into two groups based on their ability to cause disease: low pathogenic avian influenza (LPAI) and high pathogenic avian influenza (HPAI). Prior infection with LPAI provides partial immunity towards HPAI. The model introduced in this paper structures LPAI-recovered birds (wild and domestic) with time-since-recovery and includes cross-immunity towards HPAI that can fade with time. The model has a unique disease-free equilibrium (DFE), unique LPAI-only and HPAI-only equilibria and at least one coexistence equilibrium. We compute the reproduction numbers of LPAI ([Formula: see text]) and HPAI ([Formula: see text]) and show that the DFE is locally asymptotically stable when [Formula: see text] and [Formula: see text]. A unique LPAI-only (HPAI-only) equilibrium exists when [Formula: see text] ([Formula: see text]) and it is locally asymptotically stable if HPAI (LPAI) cannot invade the equilibrium, that is, if the invasion number [Formula: see text] ([Formula: see text]). We show using numerical simulations that the ODE version of the model, which is obtained by discarding the time-since-recovery structures (making cross-immunity constant), can exhibit oscillations, and also that the pathogens LPAI and HPAI can coexist with sustained oscillations in both populations. Through simulations, we show that even if both populations (wild and domestic) are sinks when alone, LPAI and HPAI can persist in both populations combined. Thus, reducing the reproduction numbers of LPAI and HPAI in each population to below unity is not enough to eradicate the disease. The pathogens can continue to coexist in both populations unless transmission between the populations is reduced.
authors.affiliation: a Department of Mathematical Sciences , Florida Atlantic University , 777 Glades Road, Boca Raton1 , FL 3343 , USA.
authors.forename: Necibe
authors.initials: N
authors.lastname: Tuncer
authors.affiliation: b Department of Mathematics , University of Florida , 358 Little Hall, PO Box 118105 , Gainesville , FL 32611-8105 , USA.
authors.forename: Juan
authors.initials: J
authors.lastname: Torres
authors.affiliation: b Department of Mathematics , University of Florida , 358 Little Hall, PO Box 118105 , Gainesville , FL 32611-8105 , USA.
authors.forename: Maia
authors.initials: M
authors.lastname: Martcheva
authors.affiliation: c Department of Biology , University of Florida , 111 Bartram, PO Box 118525 , Gainesville , FL 32611-8525 , USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Barfield
authors.affiliation: c Department of Biology , University of Florida , 111 Bartram, PO Box 118525 , Gainesville , FL 32611-8525 , USA.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Holt
mesh_terms: D000818:Animals; D000829:Animals, Domestic; D000835:Animals, Wild; D001717:Birds / Q000821:virology*; D006801:Humans; D009980:Influenza A virus / Q000302:isolation & purification / Q000472:pathogenicity*; D005585:Influenza in Birds / Q000821:virology*; D008962:Models, Theoretical
keywords: 92D30; 92D40; H5N1; HPAI; LPAI; Mathematical models; age-structured differential equations; avian influenza; invasion number; reproduction number