title: HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults.
abstract: Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of human immunodeficiency virus (HIV) coinfection. The factors driving different outcomes are not well understood, but there is increasing interest in an HLA class I effect. We therefore studied the influence of HLA class I on HBV in an African HIV-positive cohort. We demonstrated that virologic markers of HBV disease activity (hepatitis B e antigen status or HBV DNA level) are associated with HLA-A genotype. This finding supports the role of the CD8(+) T-cell response in HBV control, and potentially informs future therapeutic T-cell vaccine strategies.
authors.affiliation: Nuffield Department of Medicine Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust.
authors.forename: Philippa C
authors.initials: PC
authors.lastname: Matthews
authors.affiliation: Microsoft Research, eScience Group, Redmond, Washington.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Carlson
authors.affiliation: Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool.
authors.forename: Apostolos
authors.initials: A
authors.lastname: Beloukas
authors.affiliation: Department of Paediatrics, University of Oxford.
authors.forename: Amna
authors.initials: A
authors.lastname: Malik
authors.affiliation: Paediatric Department, Kimberley Hospital, Northern Cape.
authors.forename: Pieter
authors.initials: P
authors.lastname: Jooste
authors.affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
authors.forename: Anthony
authors.initials: A
authors.lastname: Ogwu
authors.affiliation: Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston.
authors.forename: Roger
authors.initials: R
authors.lastname: Shapiro
authors.affiliation: Integrated Sexual Health Services, Northampton General Hospital, Cliftonville.
authors.forename: Lynn
authors.initials: L
authors.lastname: Riddell
authors.affiliation: Department of Sexual Health, Royal Berkshire Hospital, Reading.
authors.forename: Fabian
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Sexual Health, High Wycombe Hospital, Buckinghamshire, United Kingdom.
authors.forename: Graz
authors.initials: G
authors.lastname: Luzzi
authors.affiliation: Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust.
authors.forename: Gerald
authors.initials: G
authors.lastname: Jesuthasan
authors.affiliation: Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust.
authors.forename: Katie
authors.initials: K
authors.lastname: Jeffery
authors.affiliation: Microsoft Research, eScience Group, Redmond, Washington.
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Jojic
authors.affiliation: HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine KwaZulu-Natal Research Institute for Tuberculosis and HIV, University of KwaZulu-Natal, South Africa Max Planck Institute for Infection Biology, Berlin, Germany The Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts.
authors.forename: Thumbi
authors.initials: T
authors.lastname: Ndung'u
authors.affiliation: The Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Maryland.
authors.forename: Mary
authors.initials: M
authors.lastname: Carrington
authors.affiliation: Department of Paediatrics, University of Oxford HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine.
authors.forename: Philip J R
authors.initials: PJ
authors.lastname: Goulder
authors.affiliation: Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Geretti
authors.affiliation: Nuffield Department of Medicine Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford.
authors.forename: Paul
authors.initials: P
authors.lastname: Klenerman
mesh_terms: D000328:Adult; D015331:Cohort Studies; D060085:Coinfection / Q000150:complications / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology / Q000821:virology; D006680:HLA Antigens / Q000235:genetics*; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D006513:Hepatitis B e Antigens / Q000097:blood*; D006801:Humans; D008297:Male; D015995:Prevalence; D012372:ROC Curve
chemical_list: D006680:HLA Antigens; D006513:Hepatitis B e Antigens
keywords: Africa; CD8+ T cells; HBV; HBeAg (hepatitis B e antigen); HIV; HLA; coinfection; immunology; viral hepatitis