title: Haemophilia A in a major trauma patient.
abstract: Haemophilia A is a coagulopathy with an absence or functional deficiency of coagulation factor VIII. The disease can be subdivided into a congenital form (incidence 1:10,000-1:20,000) and an acquired form (incidence 1:1,000,000). Both forms present an increased risk of bleeding even in low-impact trauma in severe cases of haemophilia A. The course of a man with haemorrhagic shock after a fall from a height of more than 3 m is described. After the secondary survey in the intensive care unit, several interventions (laparotomy, mass transfusion) were performed to stop the bleeding. A history of haemophilia was belatedly reported by relatives. The activity of factor VIII was determined, and substitution was initiated. No recurrent signs of bleeding occurred. The patient survived in good condition and presented for follow-up 3 years later with no disabilities.
authors.affiliation: Department of General Surgery and Trauma Surgery, BG University Hospital Bergmannsheil, Bochum, Germany.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Reinke
authors.affiliation: Department of General Surgery and Trauma Surgery, BG University Hospital Bergmannsheil, Bochum, Germany.
authors.forename: Agnes
authors.initials: A
authors.lastname: Spodeck
authors.affiliation: Department of General Surgery and Trauma Surgery, BG University Hospital Bergmannsheil, Bochum, Germany.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Schildhauer
authors.affiliation: Department of General Surgery and Trauma Surgery, BG University Hospital Bergmannsheil, Bochum, Germany.
authors.forename: Justyna
authors.identifier: http://orcid.org/0000-0002-2903-092X
authors.initials: J
authors.lastname: Swol
mesh_terms: D000058:Accidental Falls; D001803:Blood Transfusion / Q000379:methods; D003937:Diagnosis, Differential; D005169:Factor VIII / Q000008:administration & dosage / Q000627:therapeutic use; D005500:Follow-Up Studies; D006467:Hemophilia A / Q000503:physiopathology*; D006470:Hemorrhage / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007813:Laparotomy / Q000379:methods; D008297:Male; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000097:blood* / Q000628:therapy
chemical_list: D005169:Factor VIII