title: A new suprasterol by photochemical reaction of 1α,25-dihydroxy-9-methylene-19-norvitamin D3.
abstract: The UV-induced photochemical reaction of 1α,25-dihydroxy-9-methylene-19-norvitamin D3 has been investigated. The pentacyclic structure of the isolated product has been unequivocally established by X-ray crystallographic analysis. The possible reaction paths of the examined photochemical transformation are discussed. Biological in vivo and in vitro tests proved that the photoproduct is devoid of calcemic activity.
authors.affiliation: Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland. rasici@chem.uw.edu.pl and Departamento de Química Orgánica, Laboratorio de Investigación Ignacio Ribas, Universidad de Santiago de Compostela, Avda. Ciencias s/n, 15782 Santiago de Compostela, Spain. antonio.mourino@usc.es.
authors.forename: Urszula
authors.initials: U
authors.lastname: Kulesza
authors.affiliation: Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.
authors.forename: Lori A
authors.initials: LA
authors.lastname: Plum
authors.affiliation: Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.
authors.forename: Hector F
authors.initials: HF
authors.lastname: DeLuca
authors.affiliation: Departamento de Química Orgánica, Laboratorio de Investigación Ignacio Ribas, Universidad de Santiago de Compostela, Avda. Ciencias s/n, 15782 Santiago de Compostela, Spain. antonio.mourino@usc.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Mouriño
authors.affiliation: Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland. rasici@chem.uw.edu.pl.
authors.forename: Rafal R
authors.initials: RR
authors.lastname: Sicinski
mesh_terms: D018360:Crystallography, X-Ray; D018922:HL-60 Cells; D006801:Humans; D006887:Hydroxycholecalciferols / Q000737:chemistry* / Q000528:radiation effects*; D008958:Models, Molecular; D008968:Molecular Conformation; D055668:Photochemical Processes; D013261:Sterols / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: C581726:1alpha,25-dihydroxy-9-methylene-10,19-dihydrovitamin D3; D006887:Hydroxycholecalciferols; D013261:Sterols