title: Immunosurveillance and immunotherapy of tumors by innate immune cells.
abstract: Increasing evidence supports a role for innate immune effector cells in tumor surveillance. Natural killer (NK) cells and myeloid cells represent the two main subsets of innate immune cells possessing efficient but quite different tumor suppressive abilities. Here, we describe the germline-encoded NK cell receptors that play a role in suppressing tumor development and describe briefly the cellular pathways leading to the upregulation of their ligands in tumor cells. We also describe mechanisms underlying the elimination of tumor cells by macrophages and a recently characterized mechanism dedicated to sensing cytosolic DNA that is implicated in antitumor immune responses.
authors.affiliation: Department of Molecular and Cell Biology, and Cancer Research Laboratory, 489 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720, USA.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Iannello
authors.affiliation: Department of Molecular and Cell Biology, and Cancer Research Laboratory, 489 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720, USA.
authors.forename: Thornton W
authors.initials: TW
authors.lastname: Thompson
authors.affiliation: Department of Molecular and Cell Biology, and Cancer Research Laboratory, 489 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720, USA.
authors.forename: Michele
authors.initials: M
authors.lastname: Ardolino
authors.affiliation: Department of Molecular and Cell Biology, and Cancer Research Laboratory, 489 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720, USA.
authors.forename: Assaf
authors.initials: A
authors.lastname: Marcus
authors.affiliation: Department of Molecular and Cell Biology, and Cancer Research Laboratory, 489 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720, USA. Electronic address: raulet@berkeley.edu.
authors.forename: David H
authors.initials: DH
authors.lastname: Raulet
mesh_terms: D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics / Q000276:immunology; D004273:DNA, Neoplasm / Q000235:genetics / Q000276:immunology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007113:Immunity, Innate; D007157:Immunologic Surveillance; D007167:Immunotherapy / Q000379:methods; D007694:Killer Cells, Natural / Q000276:immunology* / Q000473:pathology; D008264:Macrophages / Q000276:immunology* / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics / Q000276:immunology*; D009369:Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D055607:Receptors, Natural Killer Cell / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction; D000098862:T Lineage-Specific Activation Antigen 1
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D000098862:T Lineage-Specific Activation Antigen 1; D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D055607:Receptors, Natural Killer Cell