title: Analgesic Potential of Essential Oils.
abstract: Pain is an unpleasant sensation associated with a wide range of injuries and diseases, and affects approximately 20% of adults in the world. The discovery of new and more effective drugs that can relieve pain is an important research goal in both the pharmaceutical industry and academia. This review describes studies involving antinociceptive activity of essential oils from 31 plant species. Botanical aspects of aromatic plants, mechanisms of action in pain models and chemical composition profiles of the essential oils are discussed. The data obtained in these studies demonstrate the analgesic potential of this group of natural products for therapeutic purposes.
authors.affiliation: Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, CEP 58.051-900 João Pessoa-PB, Brazil. ferreira_system@hotmail.com.
authors.forename: José Ferreira
authors.initials: JF
authors.lastname: Sarmento-Neto
authors.affiliation: Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, CEP 58.051-900 João Pessoa-PB, Brazil. lazarofarm2@gmail.com.
authors.forename: Lázaro Gomes
authors.initials: LG
authors.lastname: do Nascimento
authors.affiliation: Departamento de Biologia Molecular, Universidade Federal da Paraíba, CEP 58.051-900 João Pessoa-PB, Brazil. cicero@dbm.ufpb.br.
authors.forename: Cícero Francisco Bezerra
authors.initials: CF
authors.lastname: Felipe
authors.affiliation: Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, CEP 58.051-900 João Pessoa-PB, Brazil. sousadam@yahoo.com.
authors.forename: Damião Pergentino
authors.initials: DP
authors.lastname: de Sousa
mesh_terms: D000700:Analgesics / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D051379:Mice; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy; D051381:Rats
chemical_list: D000700:Analgesics; D001688:Biological Products; D009822:Oils, Volatile
keywords: analgesic; antinociceptive; aromatic plants; essential oils; formalin; medicinal plants; monoterpenes; natural products; pain; phenylpropanoids