title: Retreatment for prostate cancer with stereotactic body radiation therapy (SBRT): Feasible or foolhardy?
abstract: The most popular therapeutic option in the management of radio-recurrent prostatic carcinoma is represented by the androgen deprivation therapy, that however should be considered only palliative and hampered by potential adverse effects of testosterone suppression. Local therapies such as surgery, cryoablation or brachytherapy might be curative choices for patients in good conditions and with a long-life expectancy, but at cost of significant risk of failure and severe toxicity. The administration of stereotactic body radiation therapy (SBRT) in this setting have come about because of tremendous technologic advances in image guidance and treatment delivery techniques that enable the delivery of large doses to tumor with reduced margins and high gradients outside the target, thereby reducing the volume of rectum which already received significant doses from primary radiotherapy. So far, very modest data are available to support its employment. Rationale, clinical experience, and challenges are herein reviewed and discussed.
authors.affiliation: Department of Radiotherapy, Azienda Ospedaliera S. Camillo-Forlanini, Rome, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Arcangeli
authors.affiliation: Department of Radiotherapy, Azienda Ospedaliera S. Andrea - Facoltà di Medicina e Psicologia dell' Università di Roma "La Sapienza", Rome, Italy.
authors.forename: Linda
authors.initials: L
authors.lastname: Agolli
authors.affiliation: Department of Radiotherapy, Azienda Ospedaliera S. Camillo-Forlanini, Rome, Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Donato
keywords: Radiorecurrent prostatic carcinoma; SBRT; Spacer hydrogel