title: Nifty Alleles, a Plethora of Interactions, and Imagination Advance Understanding of Smc5/6's Roles with Chromosomes.
abstract: The Smc5/6 complex is involved in DNA replication and repair, but why it is essential is less clear. In this issue of Molecular Cell, Menolfi et al. (2015) use cell cycle-specific alleles to link the essential function of Smc5/6 to resolving replication problems that persist into G2.
authors.affiliation: Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Langston
authors.affiliation: Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA. Electronic address: tweinert@email.arizona.edu.
authors.forename: Ted
authors.initials: T
authors.lastname: Weinert
mesh_terms: D018797:Cell Cycle Proteins / Q000378:metabolism*; D004261:DNA Replication; D004271:DNA, Fungal / Q000378:metabolism*; D020043:Genes, Essential; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D004271:DNA, Fungal; D029701:Saccharomyces cerevisiae Proteins