title: Serum YKL-40 levels in gestational diabetes mellitus.
abstract: OBJECTIVE
  Serum YKL-40 levels are elevated in patients with type 1 and 2 diabetes. However, the correlation between YKL-40 and gestational diabetes mellitus (GDM) remains unknown. The present study compared serum YKL-40 levels in pregnant women with GDM and those with normal glucose tolerance and evaluated the relationship between YKL-40 and insulin-resistant syndrome.
  
  
  METHODS
  Thirty-five patients with GDM and 43 age-matched healthy pregnant women at 24-28 weeks of gestation were studied. In addition to anthropometric assessments, serum glucose, insulin, YKL-40, total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein and glycated hemoglobin were measured in all subjects. All subjects underwent a 2-h 75-g oral glucose tolerance test (OGTT). Body mass index (BMI) and the homeostasis model assessment of insulin resistance (HOMA-IR) were calculated.
  
  
  RESULTS
  Fasting and 2 h serum YKL-40 levels were significantly higher in pregnant women with GDM compared with controls (77.3 ± 29.3 versus 50.9 ± 16.7 ng/mL, p < 0.001, fasting concentrations; 63.5 ± 20.1 versus 40.6 ± 10.7 ng/mL, p = 0.009, 2 h concentrations). OGTT had no effect on YKL-40 levels in either group (p > 0.05). There were significant correlations between YKL-40 and glycated hemoglobin (β = 0.37, p = 0.006), fasting insulin (β = 0.49, p = 0.001) and HOMA-IR (β = 0.18, p = 0.015) in the GDM group.
  
  
  CONCLUSIONS
  Serum YKL-40 levels are elevated in patients with GDM but are unaffected by OGTT. YKL-40 levels are related to glycated hemoglobin, fasting insulin and HOMA-IR. These results suggest that YKL-40 may be a major contributor to GDM.
authors.affiliation: a Department of Endocrinology , Shandong Provincial Hospital Affiliated to Shandong University, Shandong Clinical Medical Center of Endocrinology and Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine , 324 Jing 5 Rd , Jinan , Shandong , P.R. China .|b Department of Endocrinology , Liaocheng People's Hospital , 67 Dongchang Xi Rd , Liaocheng , Shandong , P.R. China , and.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: b Department of Endocrinology , Liaocheng People's Hospital , 67 Dongchang Xi Rd , Liaocheng , Shandong , P.R. China , and.
authors.forename: Guifen
authors.initials: G
authors.lastname: Niu
authors.affiliation: c Department of Nephrology , Liaocheng People's Hospital , 67 Dongchang Xi Rd , Liaocheng , Shandong , P.R. China.
authors.forename: Huaiguo
authors.initials: H
authors.lastname: Wang
authors.affiliation: b Department of Endocrinology , Liaocheng People's Hospital , 67 Dongchang Xi Rd , Liaocheng , Shandong , P.R. China , and.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.affiliation: b Department of Endocrinology , Liaocheng People's Hospital , 67 Dongchang Xi Rd , Liaocheng , Shandong , P.R. China , and.
authors.forename: Bingtong
authors.initials: B
authors.lastname: Huang
authors.affiliation: a Department of Endocrinology , Shandong Provincial Hospital Affiliated to Shandong University, Shandong Clinical Medical Center of Endocrinology and Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine , 324 Jing 5 Rd , Jinan , Shandong , P.R. China .
authors.forename: Minglong
authors.initials: M
authors.lastname: Li
mesh_terms: D000328:Adult; D001786:Blood Glucose; D000071451:Chitinase-3-Like Protein 1 / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D016640:Diabetes, Gestational / Q000097:blood*; D005215:Fasting / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D011247:Pregnancy; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol
keywords: Gestational diabetes mellitus; YKL-40; oral glucose tolerance test