title: Design of a dietary intervention to assess the impact of a gluten-free diet in a population with type 1 Diabetes and Celiac Disease.
abstract: BACKGROUND
  Celiac Disease occurs at a 5-10 fold greater prevalence in patients with type-1 diabetes (T1D), despite this increased risk, there is limited objective evidence regarding the impact of a Gluten-Free Diet (GFD) in the large proportion of asymptomatic (30-70%) patients with both autoimmune diseases. Given the requirements and intricacies inherent to each condition, we describe the rationale and design a dietary curriculum specifically addressing the educational requirements for children and adults with CD and diabetes as part of the CD-DIET Study.
  
  
  METHODS
  The CD-DIET Study (Celiac Disease and Diabetes - Dietary Intervention and Evaluation Trial) is a multicenter randomized controlled trial aimed at evaluating the safety and efficacy of a GFD in patients with asymptomatic celiac disease and T1D on key diabetes and patient-centered outcomes.
  
  
  CONCLUSIONS
  Key dietary components of the trial include a description and evaluation of food consumption patterns including glycemic index and glycemic load, novel assessments of gluten quantification, and objective and subjective measures of GFD adherence. This dietary curriculum will establish rigorous guidelines to assess adherence and facilitate evaluation of a GFD on metabolic control, bone health and patient quality of life in patients with CD and diabetes.
  
  
  BACKGROUND
  NCT01566110. Date of Registration: March, 2012.
authors.affiliation: Department of Pediatrics, Division of Endocrinology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada. esther.assor@sickkids.ca.
authors.forename: Esther
authors.initials: E
authors.lastname: Assor
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada. peggy.marcon@sickkids.ca.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Marcon
authors.affiliation: Division of Endocrinology Paediatrics, London Health Sciences Centre, London, ON, Canada. Natasha.Hamilton@lhsc.on.ca.
authors.forename: Natasha
authors.initials: N
authors.lastname: Hamilton
authors.affiliation: Division of Endocrinology, Markham Stouffville Hospital, Toronto, ON, Canada. mfry@msh.on.ca.
authors.forename: Marilyn
authors.initials: M
authors.lastname: Fry
authors.affiliation: Division of Endocrinology and Metabolism, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. TCooper@cheo.on.ca.
authors.forename: Tammy
authors.initials: T
authors.lastname: Cooper
authors.affiliation: Department of Pediatrics, Division of Endocrinology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada. farid.mahmud@sickkids.ca.
authors.forename: Farid H
authors.initials: FH
authors.lastname: Mahmud
mesh_terms: D000293:Adolescent; D000328:Adult; D002446:Celiac Disease / Q000097:blood / Q000178:diet therapy*; D002648:Child; D003479:Curriculum; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000178:diet therapy*; D055050:Diet, Gluten-Free; D038321:Glycemic Index; D006801:Humans; D008875:Middle Aged; D010349:Patient Compliance; D010353:Patient Education as Topic; D011788:Quality of Life; D055815:Young Adult