title: Interleukin (IL)-25: Pleiotropic roles in asthma.
abstract: IL-25, also named IL-17E, is a distinct member of the IL-17 cytokine family, which can promote and augment T helper type 2 (Th2) responses locally or systemically. Growing evidence from experimental and clinical studies indicates that the expression of IL-25 and its cognate receptor, IL-17RB/RA, is markedly upregulated in asthmatic conditions. It has also been found that IL-25 induces not only typical eosinophilic inflammation and airway hyperresponsiveness (AHR), but also airway remodelling, manifested by goblet cell hyperplasia, subepithelial collagen deposition and angiogenesis. This review will focus on the discovery, cellular origins and targets of IL-25, and try to update current animal and human studies elucidating the roles of IL-25 in asthma. We conclude that although IL-25 is a pleiotropic cytokine, it may only play its dominant role in a certain specific asthmatic endotype, named 'IL-25 high' phenotype. Thus, targeting IL-25 or its receptor might selectively benefit some subgroups with asthma. Furthermore, the major IL-25 producing as well as responsive cells in the changeable milieu of asthma should be assessed in the future.
authors.affiliation: Department of Respiratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Yao
authors.affiliation: Department of Respiratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.|Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
authors.forename: Yongchang
authors.initials: Y
authors.lastname: Sun
authors.affiliation: School of Basic Medical Sciences, Capital Medical University, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: School of Basic Medical Sciences, Capital Medical University, Beijing, China.|King's College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, London, UK.
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
mesh_terms: D056151:Airway Remodeling; D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D058685:Genetic Pleiotropy; D020397:Goblet Cells / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia; D020381:Interleukin-17 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D058990:Molecular Targeted Therapy / Q000639:trends*; D015398:Signal Transduction; D018418:Th2 Cells
chemical_list: D016207:Cytokines; C508717:IL17A protein, human; C486701:IL25 protein, human; D020381:Interleukin-17
keywords: IL‐25; Th2 immunity; asthma; inflammation; remodelling