title: In vivo pink-beam imaging and fast alignment procedure for rat brain tumor radiation therapy.
abstract: A fast positioning method for brain tumor microbeam irradiations for preclinical studies at third-generation X-ray sources is described. The three-dimensional alignment of the animals relative to the X-ray beam was based on the X-ray tomography multi-slices after iodine infusion. This method used pink-beam imaging produced by the ID17 wiggler. A graphical user interface has been developed in order to define the irradiation parameters: field width, height, number of angles and X-ray dose. This study is the first reporting an image guided method for soft tissue synchrotron radiotherapy. It allowed microbeam radiation therapy irradiation fields to be reduced by a factor of ∼20 compared with previous studies. It permitted more targeted, more efficient brain tumor microbeam treatments and reduces normal brain toxicity of the radiation treatment.
authors.affiliation: European Synchrotron Radiation Facility, 38043 Grenoble, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Nemoz
authors.affiliation: INSERM, U836, F-38043 Grenoble, France.
authors.forename: Astrid
authors.initials: A
authors.lastname: Kibleur
authors.affiliation: School of Health Sciences - Geneva, University of Applied Sciences and Arts Western, Switzerland.
authors.forename: Jean Noël
authors.initials: JN
authors.lastname: Hyacinthe
authors.affiliation: European Synchrotron Radiation Facility, 38043 Grenoble, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Berruyer
authors.affiliation: European Synchrotron Radiation Facility, 38043 Grenoble, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Brochard
authors.affiliation: European Synchrotron Radiation Facility, 38043 Grenoble, France.
authors.forename: Elke
authors.initials: E
authors.lastname: Bräuer-Krisch
authors.affiliation: European Synchrotron Radiation Facility, 38043 Grenoble, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Le Duc
authors.affiliation: Department of Physics, Ludwig-Maximilians-University, Garching 85748, Germany.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Brun
authors.affiliation: INSERM, U836, F-38043 Grenoble, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Elleaume
authors.affiliation: INSERM, U836, F-38043 Grenoble, France.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Serduc
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D051381:Rats; D011916:Rats, Inbred F344
keywords: alignment procedure; brain tumors; pink-beam imaging; synchrotron microbeam radiation therapy