title: Sinonasal Lymphoma Presenting as a Probable Sanctuary Site for Relapsed B Acute Lymphoblastic Leukaemia: A Case Report and Review of the Literature.
abstract: Sinonasal lymphoma is a non-Hodgkin lymphoma (NHL) representing 1.5% of all lymphomas. It presents as an unremitting ulceration with progressive destruction of midline sinonasal and surrounding structures. Poor prognosis warrants early treatment although diagnosis is challenging and frequently delayed. It is usually primary in origin and to our knowledge the sinonasal region has never been reported as a sanctuary site in leukaemia/lymphoma relapse. We present a unique case of B-cell ALL (acute lymphoblastic leukaemia) with late relapse to the nasal septum as a sinonasal lymphoblastic lymphoma and with genetic support for this as a sanctuary site.
authors.affiliation: Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
authors.forename: W Y
authors.initials: WY
authors.lastname: Lim
authors.affiliation: Department of ORL-HNS, Dunedin Hospital, Dunedin, New Zealand.
authors.forename: R
authors.initials: R
authors.lastname: Care
authors.affiliation: Southern Community Laboratories, Dunedin, New Zealand.
authors.forename: M
authors.initials: M
authors.lastname: Lau
authors.affiliation: Department of Haematology, Dunedin Hospital, Dunedin, New Zealand.
authors.forename: S
authors.initials: S
authors.lastname: Chiruka
authors.affiliation: Department of ORL-HNS, Dunedin Hospital, Dunedin, New Zealand.
authors.forename: P J D
authors.initials: PJ
authors.lastname: Dawes