title: Serum matrix metalloproteinases-3 levels in patients with ankylosing spondylitis.
abstract: Cumulated evidence indicates that matrix metalloproteinase-3 (MMP-3) is significantly involved in cancer progression. Recent studies yielded conflicting results regarding the association between serum MMP-3 and ankylosing spondylitis (AS). To clarify this correlation, we performed a meta-analysis. Potential relevant studies were identified by searching the following databases: PubMed, Embase, CINAHL, Science Citation Index database, the Cochrane Library, Current Contents Index, Chinese Biomedical, the Chinese Journal Full-Text, and the Weipu Journal. Data from eligible studies were extracted and included into the meta-analysis using a random-effect model. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were used to assess the association between serum MMP-3 levels and AS. Thirteen case-control studies, including 707 AS cases and 442 healthy controls, were selected for the meta-analysis. The results indicate a significantly higher serum MMP-3 level in patients with AS than that in the controls (cases vs controls: SMD = 1.31, 95%CI = 0.84-1.78, P < 0.001). Ethnicity-subgroup analysis indicated a higher MMP-3 level in Asian and Caucasian patients with AS (all P < 0.05). This meta-analysis indicates that increased serum MMP-3 level correlates with the development of AS, suggesting that MMP-3 may present a clinical value in reflecting the progression of AS. Further larger sample size studies are warranted.
authors.affiliation: Department of Spine Surgery, the First People's Hospital of Jining City, Jining, China.
authors.forename: J W
authors.initials: JW
authors.lastname: Gao
authors.affiliation: Department of Spine Surgery, the First People's Hospital of Jining City, Jining, China.
authors.forename: K F
authors.initials: KF
authors.lastname: Zhang
authors.affiliation: Department of Spine Surgery, the First People's Hospital of Jining City, Jining, China.
authors.forename: J S
authors.initials: JS
authors.lastname: Lu
authors.affiliation: Department of Pediatric Surgery, the First People's Hospital of Jining City, Jining, China.
authors.forename: T
authors.initials: T
authors.lastname: Su
mesh_terms: D015415:Biomarkers; D016022:Case-Control Studies; D004198:Disease Susceptibility; D006801:Humans; D019278:Matrix Metalloproteinase 3 / Q000097:blood*; D017594:Publication Bias; D012306:Risk; D013167:Spondylitis, Ankylosing / Q000097:blood*
chemical_list: D015415:Biomarkers; D019278:Matrix Metalloproteinase 3