title: [Effectiveness of a program of early instillation single chemotherapy in patients with bladder cancer].
abstract: OBJECTIVE
  To determine the effectiveness of early intravesical chemotherapy intervention for patients with non-muscle invasive bladder cancer, before and after a training and inter-professional communication plan.
  
  
  METHODS
  Non-experimental prospective longitudinal study of a cohort of 349 patients with endoscopic diagnosis of a non-muscle invasive bladder tumour in Northern Area Health Management of Cadiz between 2010 and 2013 and amenable to postoperative treatment with mitomycin C.
  
  
  RESULTS
  The mean rate of patients included in the program was 53.9%. The inclusion rate rose by 79.3% at 3 years. The absolute risk reduction of recurrence for patients receiving treatment is 18.1% (95% CI; 8.81% - 27.48%, p<.001), and the number of patients needed to treat was 5.5 (95% CI; 3.6 - 11.3, p<.001).
  
  
  CONCLUSIONS
  A program of early postoperative chemotherapy that includes a plan for evaluation and dissemination of results has achieved a good level of adherence among professionals, obtaining the expected impact on the reduction of early recurrence of non-muscle invasive bladder cancer.
authors.affiliation: Servicio de Urología, Hospital Universitario de Álava, Vitoria, España. Electronic address: beardo.pastora@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Beardo Villar
authors.affiliation: Facultad de Medicina, Universidad de Cádiz, Cádiz, España.
authors.forename: A B
authors.initials: AB
authors.lastname: Pérez Pérez
authors.affiliation: Unidad de Gestión Clínica de Urología, Hospital de Jerez, Cádiz, España.
authors.forename: M J
authors.initials: MJ
authors.lastname: Castro Dorantes
authors.affiliation: Unidad de Gestión Clínica de Medicina Preventiva, Área de Gestión Sanitaria Norte de Cádiz, Cádiz, España.
authors.forename: S J
authors.initials: SJ
authors.lastname: Jiménez Delgado
authors.affiliation: Unidad de Gestión Clínica de Medicina Preventiva, Área de Gestión Sanitaria Norte de Cádiz, Cádiz, España.
authors.forename: P
authors.initials: P
authors.lastname: Alamillos Ortega
authors.affiliation: Unidad de Gestión Clínica de Farmacia, Área de Gestión Sanitaria Norte de Cádiz, Cádiz, España.
authors.forename: R
authors.initials: R
authors.lastname: Gavira Moreno
mesh_terms: D000283:Administration, Intravesical; D000903:Antibiotics, Antineoplastic; D006801:Humans; D008137:Longitudinal Studies; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D011446:Prospective Studies; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
chemical_list: D000903:Antibiotics, Antineoplastic
keywords: Adherencia al tratamiento; Cáncer vesical no músculo infiltrante; Early single instillation mitomycin C; Mitomicina C intravesical precoz; Non-muscle invasive bladder cancer; Treatment adherence