title: Inflammation and cutaneous nervous system involvement in hypertrophic scarring.
abstract: This study aimed to use a mouse model of hypertrophic scarring by mechanical loading on the dorsum of mice to determine whether the nervous system of the skin and inflammation participates in hypertrophic scarring. Results of hematoxylin-eosin and immunohistochemical staining demonstrated that inflammation contributed to the formation of a hypertrophic scar and increased the nerve density in scar tissue.Western blot assay verified that interleukin-13 expression was increased in scar tissue. These findings suggest that inflammation and the cutaneous nervous system play a role in hypertrophic scar formation.
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Li
authors.affiliation: Jinan Fire Protection Hospital, Jinan, Shandong Province, China.
authors.forename: Heng-Lian
authors.initials: HL
authors.lastname: Yang
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
authors.forename: Hu
authors.identifier: 0000-0002-4058-5782
authors.initials: H
authors.lastname: Xiao
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
authors.forename: Yi-Bing
authors.initials: YB
authors.lastname: Wang
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
authors.forename: De-Chang
authors.initials: DC
authors.lastname: Wang
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Huo
keywords: hypertrophic scar; interleukin-13; nerve growth factor; nerve regeneration; neural regeneration; peripheral nerve regeneration; wound healing