title: Convalescent plasma: new evidence for an old therapeutic tool?
abstract: Passive immunisation for the prevention and treatment of human infectious diseases can be traced back to the 20(th) century. The recent Ebola virus outbreak in West Africa has turned the spotlight onto the possible use of convalescent whole blood and convalescent plasma in the treatment of infectious diseases because they are the only therapeutic strategy available in some cases, given the unavailability of vaccines, drugs or other specific treatments. Convalescent blood products could be a valid option in the treatment/prophylaxis of several infectious diseases both in association with other drugs/preventive measures and as the only therapy when a specific treatment is not available. However, there are still some issues to consider in determining the advisability of implementing a large-scale convalescent plasma transfusion programme.
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Marano
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.|Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Vaglio
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.
authors.forename: Simonetta
authors.initials: S
authors.lastname: Pupella
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.|Immunohaemathology and Transfusion Medicine Unit, Azienda Ospedaliera "Città della Salute e della Scienza", Turin, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Facco
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.
authors.forename: Liviana
authors.initials: L
authors.lastname: Catalano
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.
authors.forename: Giancarlo M
authors.initials: GM
authors.lastname: Liumbruno
authors.affiliation: Italian National Blood Centre, National Institute of Health, Rome, Italy.
authors.forename: Giuliano
authors.initials: G
authors.lastname: Grazzini
mesh_terms: D000354:Africa, Western; D016913:Blood Component Transfusion; D003289:Convalescence; D004196:Disease Outbreaks; D029043:Ebolavirus; D019142:Hemorrhagic Fever, Ebola / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D010949:Plasma