title: Secondary metabolites from Scrophularia canina L.
abstract: A re-examination of Scrophularia canina L. confirmed the presence of iridoid glucosides considered as chemotaxonomic markers for the Scrophulariaceae family, like aucubin, harpagide and 8-O-acetylharpagide, besides the further presence of 8-epiloganic acid, which is, indeed, considered the biogenetic precursor of iridoids normally found in Scrophulariaceae, and was recognised here for the first time in the studied species. Also verbascoside and (E)-phytol were evidenced for the first time in S. canina. The former compound is an almost ubiquitous glycosidic phenyl-ethanoid, which attains systematic importance when in co-occurrence with iridoids, and its taxonomical implications were discussed. The latter compound, even though it is omnipresent, is interestingly endowed with several biological activities, which may give an additional reason for the traditional uses of this plant.
authors.affiliation: a Dipartimento di Chimica Piazzale Aldo Moro , Università di Roma "La Sapienza" , Roma , Italy.|b Dipartimento di Biologia Ambientale Piazzale Aldo Moro , Università di Roma "La Sapienza" , Roma , Italy.
authors.forename: A
authors.initials: A
authors.lastname: Venditti
authors.affiliation: b Dipartimento di Biologia Ambientale Piazzale Aldo Moro , Università di Roma "La Sapienza" , Roma , Italy.
authors.forename: C
authors.initials: C
authors.lastname: Frezza
authors.affiliation: a Dipartimento di Chimica Piazzale Aldo Moro , Università di Roma "La Sapienza" , Roma , Italy.
authors.forename: M
authors.initials: M
authors.lastname: Riccardelli
authors.affiliation: b Dipartimento di Biologia Ambientale Piazzale Aldo Moro , Università di Roma "La Sapienza" , Roma , Italy.
authors.forename: S
authors.initials: S
authors.lastname: Foddai
authors.affiliation: b Dipartimento di Biologia Ambientale Piazzale Aldo Moro , Università di Roma "La Sapienza" , Roma , Italy.
authors.forename: M
authors.initials: M
authors.lastname: Nicoletti
authors.affiliation: b Dipartimento di Biologia Ambientale Piazzale Aldo Moro , Università di Roma "La Sapienza" , Roma , Italy.
authors.forename: M
authors.initials: M
authors.lastname: Serafini
authors.affiliation: a Dipartimento di Chimica Piazzale Aldo Moro , Università di Roma "La Sapienza" , Roma , Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bianco
mesh_terms: D002965:Classification; D057888:Iridoid Glucosides / Q000737:chemistry; D057889:Iridoid Glycosides; D039823:Iridoids; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D032266:Scrophularia / Q000737:chemistry* / Q000145:classification
chemical_list: D057888:Iridoid Glucosides; D057889:Iridoid Glycosides; D039823:Iridoids; D010936:Plant Extracts; C006650:aucubin
keywords: Secondary metabolites; chemotaxonomy; iridoid glucosides; phenyl-propanoid glucosides; traditional uses