title: HIV-1 Cell-to-Cell Transmission and Antiviral Strategies: An Overview.
abstract: HIV-1 replicates by infecting new target cells either as cell-free viral particle or, much more efficiently, via cell-to-cell viral transmission. Cell-mediated viral spread, in which the infected cell directly transfers the viral particles to target cells via cell-cell contacts, in vitro is up to three orders of magnitude more efficient than transmission mediated by cell-free viral particles. Because of its potency, it has been suggested that current antiretroviral treatments could be less effective in blocking cell-to-cell viral transmission than cell-free. In this review, I will present an overview of the drugbased antiretroviral approaches as well as how the recently identified class of anti-HIV-1 broadly neutralizing antibodies could become part of an effective anti-viral strategy. I will discuss how both treatment strategies can be guided by our consideration that cell-to-cell HIV-1 spread is a major route of viral spread also in vivo.
authors.affiliation: Institut Pasteur, Department of Virology, Virus & Immunity Unit, Paris 75015, France; and CNRS URA 3015, Paris 75015, France. nicoletta.casartelli@gmail.com.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Casartelli
mesh_terms: D044966:Anti-Retroviral Agents / Q000494:pharmacology*; D055808:Drug Discovery; D015483:HIV Antibodies / Q000494:pharmacology*; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D006801:Humans; D018406:Virus Physiological Phenomena
chemical_list: D044966:Anti-Retroviral Agents; D015483:HIV Antibodies