title: [Expression of full-length spleen tyrosine kinase in the oral squamous cell carcinoma and its relationship with tumor invasion and metastasis].
abstract: OBJECTIVE
  To investigate the expression of full-length spleen tyrosine kinase [SYK (L)] mRNA and protein in human oral squamous cell carcinoma (OSCC) as well as its possible effects on the invasion and metastasis of OSCC.
  
  
  METHODS
  The expression of SYK (L) was detected in 27 cases of OSCC tissues and its matched adjacent non-cancerous tissues by real-time quantitative polymerase chain reaction (RT-qPCR), Western blot, and immunohistochemistry. Fourteen cases of normal oral gingival tissues were also analyzed as a normal control.
  
  
  RESULTS
  Reduced mRNA and protein expression of SYK (L) in OSCC tissues was observed compared with that in normal oral gingival tissues (P<0.01) and adjacent non-cancerous tissues (P<0.05). SYK(L) expression was significantly associated with lymph-node metastasis (P<0.05).
  
  
  CONCLUSIONS
  SYK(L) is a candidate tumor suppressor for OSCC tissues, and has an inhibitive effect on the initiation, proliferation, and lymph-node metastasis of human OSCC.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Weiming
authors.initials: W
authors.lastname: Chu
authors.forename: Mingjie
authors.initials: M
authors.lastname: Da
authors.forename: Lu
authors.initials: L
authors.lastname: Ma
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhong
authors.forename: Zilu
authors.initials: Z
authors.lastname: Wang
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Song
authors.forename: Yunong
authors.initials: Y
authors.lastname: Wu
mesh_terms: D015153:Blotting, Western; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms / Q000378:metabolism*; D012333:RNA, Messenger; D000072377:Syk Kinase / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D000072377:Syk Kinase