title: Drug release kinetics from carboxymethylcellulose-bacterial cellulose composite films.
abstract: Composite films of sodium carboxymethyl cellulose and bacterial cellulose (NaCMC-BC) cross-linked with citric acid (CA) were prepared by solution casting method. Ibuprofen sodium salt (IbuNa) has been used to study the mechanism of drug release from composite films. Surface morphology was investigated by scanning electron microscopy (SEM) and proved that the BC content influences the aspect of the films. Fourier transformed infrared spectroscopy (FTIR) revealed specific peaks in IR spectra of composite films which sustain that NaCMC was cross-linked with CA. Starting from swelling observations, the release kinetic of IbuNa was described using a model which neglects the volume expansion due to polymer swelling and which considers non-linear diffusion coefficients for drug and solvent. The IbuNa release is also influenced by BC content, the drug release rate was decreasing with the increase of BC content.
authors.affiliation: University "Politehnica" of Bucharest, Faculty of Applied Chemistry and Material Science Polizu 1-3, Bucharest 011061, Romania.
authors.forename: Gheorghe
authors.initials: G
authors.lastname: Juncu
authors.affiliation: University "Politehnica" of Bucharest, Faculty of Applied Chemistry and Material Science Polizu 1-3, Bucharest 011061, Romania. Electronic address: stoica.anicuta@gmail.com.
authors.forename: Anicuta
authors.initials: A
authors.lastname: Stoica-Guzun
authors.affiliation: University "Politehnica" of Bucharest, Faculty of Applied Chemistry and Material Science Polizu 1-3, Bucharest 011061, Romania.
authors.forename: Marta
authors.initials: M
authors.lastname: Stroescu
authors.affiliation: University "Politehnica" of Bucharest, Faculty of Applied Chemistry and Material Science Polizu 1-3, Bucharest 011061, Romania.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Isopencu
authors.affiliation: University "Politehnica" of Bucharest, Faculty of Applied Chemistry and Material Science Polizu 1-3, Bucharest 011061, Romania.
authors.forename: Sorin Ion
authors.initials: SI
authors.lastname: Jinga
mesh_terms: D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D019343:Citric Acid / Q000737:chemistry; D065546:Drug Liberation; D007052:Ibuprofen / Q000737:chemistry; D007700:Kinetics; D008855:Microscopy, Electron, Scanning / Q000379:methods; D011108:Polymers / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods
chemical_list: D011108:Polymers; D019343:Citric Acid; D002482:Cellulose; D002266:Carboxymethylcellulose Sodium; D007052:Ibuprofen
keywords: Bacterial cellulose; Citric acid cross-linking; Controlled release; Ibuprofen sodium salt; Mathematical modeling; Sodium carboxymethyl cellulose