title: Association between Plasma Leptin and Estrogen in Female Patients of Amnestic Mild Cognitive Impairment.
abstract: Increasing evidences suggested the association between leptin and cognitive functions. Estrogen is an important factor that regulates the production and metabolism of leptin. However, little is known about the relationship between leptin and estrogen in mild cognitive impairment (MCI). Plasma levels of leptin, total estradiol, and β-amyloid protein (Aβ) were measured in a total of 23 female amnestic MCI (aMCI) patients and 19 female cognitively normal controls. This study showed that female aMCI patients had lower plasma levels of leptin and higher levels of estradiol compared to female normal controls. Leptin and estradiol levels were not correlated with cognitive performances or plasma Aβ levels in either aMCI patients or normal controls. There was a significant negative correlation between leptin and estrogen in female aMCI patients (r = -0.633, p = 0.002) but not in female normal controls. The potential mechanisms of this disease-stage-specific association between leptin and estrogen need further investigations.
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.
authors.forename: Jianghong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, Capital Medical University, 10 Xitoutiao, Youanmen, Fengtai District, Beijing 100069, China.
authors.forename: Jingdong
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Pharmacology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China ; Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Disease of Ministry of Education, 45 Changchun Street, Beijing 100053, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Yin
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.
authors.forename: Fangyu
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Gao
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Jia
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003071:Cognition; D060825:Cognitive Dysfunction / Q000097:blood* / Q000175:diagnosis; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008568:Memory
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D020738:Leptin; D004958:Estradiol