title: The Role of Neuromediators and Innervation in Cutaneous Wound Healing.
abstract: The skin is densely innervated with an intricate network of cutaneous nerves, neuromediators and specific receptors which influence a variety of physiological and disease processes. There is emerging evidence that cutaneous innervation may play an important role in mediating wound healing. This review aims to comprehensively examine the evidence that signifies the role of innervation during the overlapping stages of cutaneous wound healing. Numerous neuropeptides that are secreted by the sensory and autonomic nerve fibres play an essential part during the distinct phases of wound healing. Delayed wound healing in diabetes and fetal cutaneous regeneration following wounding further highlights the pivotal role skin innervation and its associated neuromediators play in wound healing. Understanding the mechanisms via which cutaneous innervation modulates wound healing in both the adult and fetus will provide opportunities to develop therapeutic devices which could manipulate skin innervation to aid wound healing.
authors.affiliation: Plastic and Reconstructive Surgery Research, Centre for Dermatological Research,, Institute of Inflammation and Repair, University of Manchester, M13 9PT Manchester, United Kingdom. mohammedashrafi@doctors.org.uk, mohammed.ashrafi@nhs.net.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Ashrafi
authors.forename: Mohamed
authors.initials: M
authors.lastname: Baguneid
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Bayat
mesh_terms: D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D012867:Skin / Q000294:innervation*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D009414:Nerve Growth Factors; D009479:Neuropeptides; D018377:Neurotransmitter Agents