title: Resveratrol Enhances Neuroplastic Changes, Including Hippocampal Neurogenesis, and Memory in Balb/C Mice at Six Months of Age.
abstract: Resveratrol (RVTL) is a flavonoid found in red wine and has been publicized heavily as an anti-aging compound. Indeed, basic research confirms that although there is much hype in the promotion of RVTL, flavonoids such as RVTL have a wide range of biological effects. We here investigated the effects of RVTL treatment on hippocampal plasticity and memory performance in female Balb/C mice, a strain with low baseline levels of adult neurogenesis. Two weeks of treatment with RVTL (40 mg/kg) induced the production of new neurons in vivo by increasing cell survival and possibly precursor cell proliferation. In addition, RVTL decreased the number of apoptotic cells. The number of doublecortin (DCX)-expressing intermediate cells was increased. RVTL stimulated neuronal differentiation in vitro without effects on proliferation. In the dentate gyrus, RVTL promoted the formation and maturation of spines on granule cell dendrites. RVTL also improved performance in the step down passive avoidance test. The RVTL-treated mice showed increase in the levels of two key signaling proteins, phospho-Akt and phospho-PKC, suggesting the involvement of these signaling pathways. Our results support the vision that flavonoids such as resveratrol deserve further examination as plasticity-inducing compounds in the context of successful cognitive aging.
authors.affiliation: Laboratory of Neurogenesis, Division of Clinical Investigations, National Institute of Psychiatry "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, 14370, México, D.F., México.
authors.forename: Mario
authors.initials: M
authors.lastname: Torres-Pérez
authors.affiliation: Laboratory of Neurogenesis, Division of Clinical Investigations, National Institute of Psychiatry "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, 14370, México, D.F., México.
authors.forename: Ruth Ivonne
authors.initials: RI
authors.lastname: Tellez-Ballesteros
authors.affiliation: Laboratory of Neurogenesis, Division of Clinical Investigations, National Institute of Psychiatry "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, 14370, México, D.F., México.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Ortiz-López
authors.affiliation: CRTD - Center for Regenerative Therapies Dresden, Tatzberg 47-79, 01307, Dresden, Germany.|Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Sumatera Utara, Jalan Dr. Mansur 5, Medan, Indonesia.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ichwan
authors.affiliation: Laboratory of Neuropsychopharmacology, Division of Neurosciences, National Institute of Psychiatry "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, 14370, México, D.F., México.
authors.forename: Nelly Maritza
authors.initials: NM
authors.lastname: Vega-Rivera
authors.affiliation: Laboratory of Neuropsychopharmacology, Division of Neurosciences, National Institute of Psychiatry "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, 14370, México, D.F., México.
authors.forename: Mario
authors.initials: M
authors.lastname: Castro-García
authors.affiliation: Laboratory of Neurogenesis, Division of Clinical Investigations, National Institute of Psychiatry "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, 14370, México, D.F., México.
authors.forename: Ariadna
authors.initials: A
authors.lastname: Gómez-Sánchez
authors.affiliation: CRTD - Center for Regenerative Therapies Dresden, Tatzberg 47-79, 01307, Dresden, Germany.|DZNE, German Center for Neurodegenerative Diseases, Dresden, Tatzberg 47-49, 01307, Dresden, Germany.
authors.forename: Gerd
authors.initials: G
authors.lastname: Kempermann
authors.affiliation: Laboratory of Neurogenesis, Division of Clinical Investigations, National Institute of Psychiatry "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, 14370, México, D.F., México.
authors.forename: Gerardo Bernabe
authors.initials: GB
authors.lastname: Ramirez-Rodriguez
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D000089622:Doublecortin Domain Proteins; D000089662:Doublecortin Protein; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis; D055495:Neurogenesis / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000187:drug effects*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D009479:Neuropeptides / Q000096:biosynthesis; D011493:Protein Kinase C / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: C000714847:Dcx protein, mouse; D000089622:Doublecortin Domain Proteins; D000089662:Doublecortin Protein; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides; D013267:Stilbenes; D051057:Proto-Oncogene Proteins c-akt; D011493:Protein Kinase C; D000077185:Resveratrol