title: Research Advances on Pathways of Nickel-Induced Apoptosis.
abstract: High concentrations of nickel (Ni) are harmful to humans and animals. Ni targets a number of organs and produces multiple toxic effects. Apoptosis is important in Ni-induced toxicity of the kidneys, liver, nerves, and immune system. Apoptotic pathways mediated by reactive oxygen species (ROS), mitochondria, endoplasmic reticulum (ER), Fas, and c-Myc participate in Ni-induced cell apoptosis. However, the exact mechanism of apoptosis caused by Ni is still unclear. Understanding the mechanism of Ni-induced apoptosis may help in designing measures to prevent Ni toxicity.
authors.affiliation: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agricultural University, Ya'an 625014, China. guohonrui@163.com.
authors.forename: Hongrui
authors.initials: H
authors.lastname: Guo
authors.affiliation: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agricultural University, Ya'an 625014, China. lianchen87@163.com.
authors.forename: Lian
authors.initials: L
authors.lastname: Chen
authors.affiliation: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agricultural University, Ya'an 625014, China. cuihengmin2008@sina.com.|College of Veterinary Medicine, Sichuan Agricultural University Ya'an, Ya'an 625014, China. cuihengmin2008@sina.com.
authors.forename: Hengmin
authors.initials: H
authors.lastname: Cui
authors.affiliation: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agricultural University, Ya'an 625014, China. pengxi197313@163.com.|College of Veterinary Medicine, Sichuan Agricultural University Ya'an, Ya'an 625014, China. pengxi197313@163.com.
authors.forename: Xi
authors.initials: X
authors.lastname: Peng
authors.affiliation: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agricultural University, Ya'an 625014, China. fangjing4109@163.com.|College of Veterinary Medicine, Sichuan Agricultural University Ya'an, Ya'an 625014, China. fangjing4109@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Fang
authors.affiliation: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agricultural University, Ya'an 625014, China. zzcjl@126.com.|College of Veterinary Medicine, Sichuan Agricultural University Ya'an, Ya'an 625014, China. zzcjl@126.com.
authors.forename: Zhicai
authors.initials: Z
authors.lastname: Zuo
authors.affiliation: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agricultural University, Ya'an 625014, China. dengjl213@126.com.|College of Veterinary Medicine, Sichuan Agricultural University Ya'an, Ya'an 625014, China. dengjl213@126.com.
authors.forename: Junliang
authors.initials: J
authors.lastname: Deng
authors.affiliation: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agricultural University, Ya'an 625014, China. wangxun99@163.com.|College of Veterinary Medicine, Sichuan Agricultural University Ya'an, Ya'an 625014, China. wangxun99@163.com.
authors.forename: Xun
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agricultural University, Ya'an 625014, China. wubangyuan2008@163.com.
authors.forename: Bangyuan
authors.initials: B
authors.lastname: Wu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009532:Nickel / Q000633:toxicity*; D014131:Trace Elements / Q000633:toxicity*
chemical_list: D051017:Apoptosis Regulatory Proteins; D014131:Trace Elements; D009532:Nickel
keywords: Ni; apoptosis; endoplasmic reticulum; mitochondria; molecular mechanism