title: Isolated double-orifice mitral valve: a case report.
abstract: BACKGROUND
  Double-orifice mitral valve is an extremely rare cardiac anomaly possibly originating from insufficient endocardial fusion in embryogenesis. Severe concomitant cardiac anomalies and malfunction of the valve usually lead to an early diagnosis in childhood. Therefore the prevalence of isolated double-orifice mitral valve in adulthood is not known.
  
  
  METHODS
  We present the case of a 63 years old, female Caucasian patient with isolated double-orifice mitral valve diagnosed in routine echocardiographic evaluation after chemotherapy presenting without clinical symptoms.
  
  
  CONCLUSIONS
  Trans-thoracic echocardiography is a suitable modality to diagnose and further assess anatomical and functional properties of the anomaly. In the presence of double-orifice mitral valve concomitant cardiac anomalies and valvular stenosis or regurgitation must be excluded. If an isolated double-orifice mitral valve with no functional abnormalities is present, no further follow-up is necessary.
authors.affiliation: Department of Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland. philipp.krisai@usb.ch.|Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland. philipp.krisai@usb.ch.
authors.forename: Philipp
authors.initials: P
authors.lastname: Krisai
authors.affiliation: Department of Cardiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland. bastian.wein@usb.ch.
authors.forename: Bastian
authors.initials: B
authors.lastname: Wein
authors.affiliation: Department of Cardiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland. beat.kaufmann@usb.ch.
authors.forename: Beat A
authors.initials: BA
authors.lastname: Kaufmann
mesh_terms: D018618:Echocardiography, Doppler, Color; D005260:Female; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D033162:Incidental Findings; D008875:Middle Aged; D008943:Mitral Valve / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000503:physiopathology; D011237:Predictive Value of Tests