title: Development of Highly Functional Biomaterials by Decoupling and Recombining Material Properties.
abstract: Development of functional biomaterials by a design-driven approach is described, whereby individual properties are first decoupled to investigate their sole effects on a biological process. Following this investigation, they are recombined in such a way that the overall performance and applicability of the biomaterial is improved. This is in contrast to classical, processing-driven biomaterials development where the properties of a material are mainly determined by the possibilities of the technique used to produce it.
authors.affiliation: Department of Tissue Regeneration, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
authors.forename: Charlène
authors.initials: C
authors.lastname: Danoux
authors.affiliation: Department of Tissue Regeneration, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.|Oral Implantology Center, Stomotology Hospital of Jinan, Jingliu Road 101, 250001, Jinan, China.|Department of Oral Implantology, Shangdong University, Wenhuaxi Road 44-1, 250012, Jinan, China.
authors.forename: Lanying
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Tissue Regeneration, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
authors.forename: Gülistan
authors.initials: G
authors.lastname: Koçer
authors.affiliation: Department of Tissue Regeneration, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
authors.forename: Zeinab Tahmasebi
authors.initials: ZT
authors.lastname: Birgani
authors.affiliation: Department of Tissue Regeneration, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
authors.forename: David
authors.initials: D
authors.lastname: Barata
authors.affiliation: Faculty of Dentistry, McGill University, 3640 University Street, Montreal, QC, H3A 2B2, Canada.
authors.forename: Jake
authors.initials: J
authors.lastname: Barralet
authors.affiliation: Department of Tissue Regeneration, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.|MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
authors.forename: Clemens
authors.initials: C
authors.lastname: van Blitterswijk
authors.affiliation: Department of Tissue Regeneration, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.|MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
authors.forename: Roman
authors.initials: R
authors.lastname: Truckenmüller
authors.affiliation: Department of Tissue Regeneration, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.|MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
authors.forename: Pamela
authors.initials: P
authors.lastname: Habibovic
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D055396:Bone Morphogenetic Protein 2 / Q000235:genetics; D002130:Calcium Phosphates / Q000737:chemistry; D015195:Drug Design; D020724:Elastomers / Q000737:chemistry; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000378:metabolism; D008958:Models, Molecular; D008968:Molecular Conformation; D053495:Osteopontin / Q000235:genetics; D013499:Surface Properties
chemical_list: C525718:BMP2 protein, human; D001672:Biocompatible Materials; D055396:Bone Morphogenetic Protein 2; D002130:Calcium Phosphates; D020724:Elastomers; D053495:Osteopontin; C020243:calcium phosphate
keywords: calcium phosphates; composites; nanoimprinting; osteogenic differentiation; property-function relationships