title: Hexanucleotide Repeat Expansion in C9ORF72 Is Not Detected in the Treatment-Resistant Schizophrenia Patients of Chinese Han.
abstract: Hexanucleotide (GGGGCC) repeat expansion in C9ORF72 (HRE) causes frontotemporal lobar degeneration, frontotemporal dementia-amyotrophic lateral sclerosis, and amyotrophic lateral sclerosis. HRE was also seen in the genomes of patients suffering from several other degenerative diseases. However, whether it is present in the treatment-resistant schizophrenia patients remains unknown. Genotyping 386 patients suffering from treatment-resistant schizophrenia using the method of Repeat-Primed PCR, we reported here that no HRE was detected in the patients of Chinese Han.
authors.affiliation: Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.|Nanjing Brain Hospital, Nanjing University Medical School, Nanjing, 210093, China.
authors.forename: Xijia
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.|Nanjing Brain Hospital, Nanjing University Medical School, Nanjing, 210093, China.
authors.forename: Shiping
authors.initials: S
authors.lastname: Xie
authors.affiliation: Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Shi
authors.affiliation: Department of Psychiatry, Nanjing Qinglongshan Mental Hospital, Nanjing, 211123, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Lv
authors.affiliation: Department of Psychiatry, Affiliated Wutaishan Hospital of Medical College of Yangzhou University, Yangzhou, 225003, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Shuiping
authors.initials: S
authors.lastname: Lu
authors.affiliation: Department of Psychiatry, Nanjing Qinglongshan Mental Hospital, Nanjing, 211123, China.
authors.forename: Mingzhong
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, Affiliated Wutaishan Hospital of Medical College of Yangzhou University, Yangzhou, 225003, China.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000627:therapeutic use; D044466:Asian People / Q000235:genetics; D000073885:C9orf72 Protein; D016022:Case-Control Studies; D042622:DNA Repeat Expansion; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D000073885:C9orf72 Protein; C568651:C9orf72 protein, human; D011506:Proteins