title: Primary Gastrointestinal Non-Hodgkin's Lymphoma of the Small and Large Intestines: a Systematic Review.
abstract: BACKGROUND
  Primary gastrointestinal non-Hodgkin's lymphoma (PGINHL) of small and large intestines is a group of heterogeneous, rare malignancies. Optimal treatment practices remain undefined.
  
  
  METHODS
  A systematic review (2003-2015) was performed to assess tumor characteristics, treatment practices, and treatment outcomes of PGINHL of small and large intestines.
  
  
  RESULTS
  Twenty-eight studies (1658 patients) were included; five focused on follicular lymphoma subtype. Of the non-follicular patients, 59.3% presented with abdominal pain, 37.2% were located in ileocecum, and 53.6% were diffuse large B cell lymphoma subtype. The majority of patients (60.7%) were treated with a combination of surgery and chemotherapy. Forty-three percent of studies concluded an overall survival benefit with surgery; none reported increased postoperative morbidity or mortality. Survival outcomes were not typically stratified by emergent versus elective surgery. Multivariate analysis within individual studies associated B cell lymphoma and ileocecum location with higher survival, while advanced stage and B symptoms were associated with poorer survival. Patients with asymptomatic follicular lymphoma had no progression with a watchful waiting approach.
  
  
  CONCLUSIONS
  The majority of patients with non-follicular small and large intestinal PGINHLs are treated with both chemotherapy and surgery. Although surgery appears to be an important part of the treatment algorithm, definitive statements regarding its survival benefit remain limited due to lack of patient stratification based on timing and indication for surgery.
authors.affiliation: Department of Surgery, David Geffen School of Medicine at the University of California at Los Angeles, 200 1st St. SW Rochester, MN 55905, Los Angeles, CA, USA. Lightner.amy@mayo.edu.
authors.forename: Amy L
authors.initials: AL
authors.lastname: Lightner
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Evan
authors.initials: E
authors.lastname: Shannon
authors.affiliation: Department of Surgery, David Geffen School of Medicine at the University of California at Los Angeles, 200 1st St. SW Rochester, MN 55905, Los Angeles, CA, USA.
authors.forename: Melinda Maggard
authors.initials: MM
authors.lastname: Gibbons
authors.affiliation: Department of Surgery, David Geffen School of Medicine at the University of California at Los Angeles, 200 1st St. SW Rochester, MN 55905, Los Angeles, CA, USA.|VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
authors.forename: Marcia M
authors.initials: MM
authors.lastname: Russell
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D006801:Humans; D007414:Intestinal Neoplasms / Q000473:pathology* / Q000628:therapy*; D007420:Intestine, Large; D007421:Intestine, Small; D008224:Lymphoma, Follicular / Q000473:pathology / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D015996:Survival Rate; D016896:Treatment Outcome
keywords: Large intestine; Lymphoma; Outcomes; Small intestine; Surgery