title: Genetic description of a tick-borne encephalitis virus strain Sofjin with the longest history as a vaccine strain.
abstract: Vaccines based on the strain Sofjin of the Far-Eastern tick-borne encephalitis virus (TBEV) subtype have been used for TBE prophylaxis for over 50 years in Russia and neighboring countries. On the wide territory, where all known TBEV subtypes are circulating, the cultural, purified, concentrated, inactivated TBE vaccine Moscow has been shown to be safe and efficacious in a massive immunization. In the present work, we describe the genome of the vaccine strain Sofjin. We have shown that it differs from TBEV strains previously published with the name "Sofjin". Moreover, we have shown the stability of the virus during the vaccine manufacturing process on the molecular level.
authors.affiliation: Federal State Unitary Enterprise on Manufacture of Bacterial and Viral Preparations of Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, 142782 Russia ; Chumakov Institute of Poliomyelitis and Viral Encephalitides, Institut Poliomyelita, Moscow, 142782 Russia.
authors.forename: M F
authors.initials: MF
authors.lastname: Vorovitch
authors.affiliation: Chumakov Institute of Poliomyelitis and Viral Encephalitides, Institut Poliomyelita, Moscow, 142782 Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Kozlovskaya
authors.affiliation: Chumakov Institute of Poliomyelitis and Viral Encephalitides, Institut Poliomyelita, Moscow, 142782 Russia.
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Romanova
authors.affiliation: Chumakov Institute of Poliomyelitis and Viral Encephalitides, Institut Poliomyelita, Moscow, 142782 Russia.
authors.forename: L L
authors.initials: LL
authors.lastname: Chernokhaeva
authors.affiliation: Federal State Unitary Enterprise on Manufacture of Bacterial and Viral Preparations of Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, 142782 Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Ishmukhametov
authors.affiliation: Chumakov Institute of Poliomyelitis and Viral Encephalitides, Institut Poliomyelita, Moscow, 142782 Russia.
authors.forename: G G
authors.initials: GG
authors.lastname: Karganova
keywords: Strain Sofjin; TBE vaccine; TBEV