title: Activation of Helicobacter pylori causes either autoimmune thyroid diseases or carcinogenesis in the digestive tract.
abstract: Helicobacter pylori has been implicated in stimulation of immune system, development of autoimmune endocrinopathies as autoimmune thyroiditis (AT) and on other hand induction of immunosupresion activates gastric and extra-gastric diseases such as gastric ulcer or cancer. It causes persistent lifelong infection despite local and systemic immune response. Our results indicate that Helicobacter pylori might cause inhibition of the specific cellular immune response in Helicobacter pylori-infected patients with or without autoimmune diseases such as AT. We cannot also declare the carcinogenic effect in oropharynx. However the association of any infection agents and cancerogenesis exists. The adherence of Helicobacter pylori expression and enlargement of benign lymphatic tissue and the high incidence of the DNA of Helicobacter pylori in laryngopharyngeal and oropharyngeal cancer is reality. LTT appears to be a good tool for detection of immune memory cellular response in patients with Helicobacter pylori infection and AT. All these complications of Helicobacter pylori infection can be abrogated by successful eradication of Helicobacter pylori.
authors.affiliation: Department of Otorhinolaryngology, Third Faculty of Medicine, Charles University and Military Faculty Hospital, Prague, Czech Republic, Department of Immunoendocrinology, Institute of Endocrinology, Prague, Czech Republic. isterzl@endo.cz.
authors.forename: J
authors.initials: J
authors.lastname: Astl
authors.forename: I
authors.initials: I
authors.lastname: Šterzl
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D016481:Helicobacter Infections / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism*; D016480:Helicobacter pylori / Q000378:metabolism*; D006801:Humans; D013959:Thyroid Diseases / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism*; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism