title: Case Report of Relay Liver Transplantation With Graft Infected With Hepatitis B Virus.
abstract: Reuse of liver graft for transplantation is extremely uncommon. We report the 1st case of reuse of liver graft from a recipient who had hepatitis B virus (HBV) infection, 11 years after the 1st transplantation. Our relay liver transplantation challenged conventional thinking because of late reuse of graft in the presence of HBV infection. Moreover, both the 1st and the 2nd donors were of advanced age. The key questions were whether the liver graft could be reused safely, especially in the setting of HBV infection, and technical concerns during organ procurement and implantation. The absence of HBV replication was confirmed with negative hepatitis B surface antigen and undetectable serum HBV DNA in the 2nd donor. Based on our experience in managing HBV infection after liver transplantation, we were confident that the adequately suppressed HBV infection in the donor would not jeopardize graft function and that the graft would be able to withstand another ischemia-perfusion injury to continue to function well in our recipient.
authors.affiliation: Department of Surgery, Queen Mary Hospital, University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: T C L
authors.initials: TC
authors.lastname: Wong
authors.affiliation: Department of Surgery, Queen Mary Hospital, University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: W H
authors.initials: WH
authors.lastname: She
authors.affiliation: Department of Surgery, Queen Mary Hospital, University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: T T
authors.initials: TT
authors.lastname: Cheung
authors.affiliation: Department of Surgery, Queen Mary Hospital, University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: S C
authors.initials: SC
authors.lastname: Chan
authors.affiliation: Department of Surgery, Queen Mary Hospital, University of Hong Kong, Hong Kong, People's Republic of China. Electronic address: chungmlo@hku.hk.
authors.forename: C M
authors.initials: CM
authors.lastname: Lo
mesh_terms: D000368:Aged; D001926:Brain Death; D004279:DNA, Viral / Q000097:blood; D017809:Fatal Outcome; D006509:Hepatitis B / Q000188:drug therapy / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology; D006801:Humans; D016031:Liver Transplantation / Q000145:classification / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D020858:Tissue and Organ Harvesting; D009927:Tissue and Organ Procurement; D019737:Transplants / Q000601:surgery / Q000637:transplantation / Q000821:virology*
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens