title: State of oral cavity hygiene, sIgA level, mineral content of oral fluid, and optimization of preventive intervention in children with enamel hypoplasia and underlying comorbidity.
abstract: OBJECTIVE
  To advance the efficiency of tooth caries prevention in children with enamel hypoplasia through a com plex intervention focused at amelioration of oral hygiene, secretory immunoglobulin A (sIgA) level, and mineral con tent of oral fluid.
  
  
  METHODS
  Hypoplasia of permanent teeth enamel was the target of research. State of oral cavity hygiene, sIgA, total calcium and orthophosphate content in oral fluid were the research subject. Enamel vital stain ing, transillumination, immunoenzymometric and photometric techniques were applied. Indices of oral cavity hygiene: simplified oral hygiene index (OHI S) by Green and Vermillion (1964) and Silness Loe (1964, 1967) plaque index were the assayed. Assessment of oral cavity hygiene and assay of sIgA, calcium and orthophosphate content in oral fluid were held in 43 children 6-14 years old (n=21, Group 1; n=22, Group 2) with a systemic enamel hypoplasia and underlying diffuse non toxic (euthyroid) goiter. All children were born from the ChNPP accident clean up work ers and evacuees from territories of mandatory resettlement. Children in the Group 1 were prescribed a set of preven tive interventions including recommendations on choice of the oral care tools and teaching the standard dental cleaning skills. Children in the Group 2 additionally used the remineralizing gel with calcium, phosphorus, magnesium and xylitol (Sanction of the State Sanitary and Epidemiological Service of Ukraine # 05.03.02 03/9351 from 07.02.2014).
  
  
  RESULTS
  State of oral cavity hygiene in children of the both study groups was assayed by a "dissatisfactory" criteri on according to the OHI S by Green and Vermillion and by a "poor" criterion according to the Silness Loe plaque index. Upon application of preventive intervrntions the state of oral cavity hygiene improved in children of Group 1 and Group 2: there was a significant decrease of OHI S by Green and Vermillion (p=0.0001) and Silness Loe plaque index (p=0.0003). Administration of remineralizing gel resulted in a significant increase of calcium (р = 0.0008) and orthophosphate (р = 0.001) content in oral fluid. No substantial change in sIgA concentration was found in both groups.
  
  
  CONCLUSIONS
  Implementation of the preventive intervention tools including preparation with remineralizing effect promoted the amelioration of oral hygiene, increased content of mineral constituents in oral fluid, however with no effect on sIgA level.
authors.affiliation: O. O. Bogomolets Memorial National Medical University, Taras Shevchenko boulvard, 13, Kyiv, 01601, Ukraine.
authors.forename: S F
authors.initials: SF
authors.lastname: Liubarets
authors.affiliation: State Institution National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine, Melnikova str., 53, Kyiv, 04050, Ukraine.
authors.forename: O V
authors.initials: OV
authors.lastname: Kopylova
authors.affiliation: State Institution National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine, Melnikova str., 53, Kyiv, 04050, Ukraine.
authors.forename: T O
authors.initials: TO
authors.lastname: Belingio
authors.affiliation: State Institution National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine, Melnikova str., 53, Kyiv, 04050, Ukraine.
authors.forename: V M
authors.initials: VM
authors.lastname: Kolbasynska
authors.affiliation: State Institution National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine, Melnikova str., 53, Kyiv, 04050, Ukraine.
authors.forename: I M
authors.initials: IM
authors.lastname: Sechina
authors.affiliation: State Institution National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine, Melnikova str., 53, Kyiv, 04050, Ukraine.
authors.forename: T F
authors.initials: TF
authors.lastname: Liubarets
keywords: calci  um of oral fluid; children; enamel hypoplasia; hygienic indices; oral prophylaxis; orthophosphates of oral fluid; secretory immunoglobulin A; teeth