title: Synthesis, cytotoxicity and anti-cancer activity of new alkynyl-gold(I) complexes.
abstract: Alkynyl(triphenylphosphine)gold(i) complexes carrying variously substituted propargylic amines have been synthesized and fully characterized in solution and solid state. High levels of toxicity (i.e. micromolar range) were recognized for a series of cancer cell lines with particular emphasis on HT29, IGROV1, HL60 and I407. In particular the lead compound 3ab was identified as the most active compound in all cell lines (IC50: 1.7-7.9 μM).
authors.affiliation: Department of Chemistry "G. Ciamician", Alma Mater Studiorum - University of Bologna, Via Selmi 2, 40126 Bologna, Italy. marco.bandini@unibo.it.
authors.forename: Assunta
authors.initials: A
authors.lastname: De Nisi
authors.forename: Christian
authors.initials: C
authors.lastname: Bergamini
authors.forename: Marco
authors.initials: M
authors.lastname: Leonzio
authors.forename: Giorgio
authors.initials: G
authors.lastname: Sartor
authors.forename: Romana
authors.initials: R
authors.lastname: Fato
authors.forename: Marina
authors.initials: M
authors.lastname: Naldi
authors.forename: Magda
authors.initials: M
authors.lastname: Monari
authors.forename: Natalia
authors.initials: N
authors.lastname: Calonghi
authors.forename: Marco
authors.initials: M
authors.lastname: Bandini
mesh_terms: D000480:Alkynes / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006046:Gold / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D050607:Organogold Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000480:Alkynes; D000970:Antineoplastic Agents; D050607:Organogold Compounds; D006046:Gold