title: Assessing the Effect of Leptin on Liver Damage in Case of Hepatic Injury Associated with Paracetamol Poisoning.
abstract: Background Aim. In case of high-dose acetaminophen intake, the active metabolite can not bind to the glutathione, thereby inducing cellular necrosis through binding to the cytosol proteins. This trial was performed to histologically and biochemically investigate whether leptin was protective against liver damage induced by paracetamol at toxic doses. Material and Method. In our trial, 30 female rats, divided into 5 groups, were used. IP leptin administration was performed after an hour in the group of rats, in which paracetamol poisoning was induced. The groups were as follows: Group 1: the control group, Group 2: 20 µg/kg leptin, Group 3: 2 g/kg paracetamol, Group 4: 2 g/kg paracetamol + 10 µg/kg leptin, and Group 5: 2 g/kg paracetamol + 20 µg/kg leptin. Results. The most significant increase was observed in the PARA 2 g/kg group, while the best improvement among the treatment groups occurred in the PARA 2 g/kg + LEP 10 µg/kg group (p < 0.05). While the most significant glutathione (GSH) reduction was observed in the PARA 2 g/kg group, the best improvement was in the PARA 2 g/kg + LEP 10 µg/kg group (p < 0.05). Conclusion. Liver damage occurring upon paracetamol poisoning manifests with hepatocyte breakdown occurring as a result of inflammation and oxidative stress. Leptin can prevent this damage thanks to its antioxidant and anti-inflammatory efficacy.
authors.affiliation: Department of Internal Medicine, Erzurum Ataturk University, Yakutiye, 25240 Erzurum, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Polat
authors.affiliation: Department of Internal Medicine, Erzurum Ataturk University, Yakutiye, 25240 Erzurum, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Cerrah
authors.affiliation: Department of Internal Medicine, Erzurum Ataturk University, Yakutiye, 25240 Erzurum, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Albayrak
authors.affiliation: Department of Gastroenterology, Erzurum Ataturk University, Yakutiye, 25240 Erzurum, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Ipek
authors.affiliation: Department of Gastroenterology, Erzurum Ataturk University, Yakutiye, 25240 Erzurum, Turkey.
authors.forename: Mahmut
authors.identifier: 0000-0002-7444-4275
authors.initials: M
authors.lastname: Arabul
authors.affiliation: Department of Gastroenterology, Erzurum Ataturk University, Yakutiye, 25240 Erzurum, Turkey.
authors.forename: Fatih
authors.identifier: 0000-0002-1002-7202
authors.initials: F
authors.lastname: Aslan
authors.affiliation: Department of Gastroenterology, Atatürk Training and Research Hospital, İzmir Katip Çelebi University, Karabaglar, 35360 İzmir, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Yilmaz