title: Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing.
abstract: The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan derivatives were investigated. The chitosan-derivative films showed a rough surface and hydrophilic properties, which are very important features for their use as a wound dressing. The film based on chitosan-sulfisoxazol (CS-S6) showed the highest swelling ratio (197%) and the highest biodegradation rate (63.04%) in comparison to chitosan film for which the swelling ratio was 190% and biodegradation rate was only 10%. Referring to the antioxidant effects the most active was chitosan-sulfamerazine (CS-S5) which was 8.3 times more active than chitosan related to DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging ability. This compound showed also a good ferric reducing power and improved total antioxidant capacity.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 16 University Street, Iasi 700115, Romania. oana.dragostin@umfiasi.ro.
authors.forename: Oana Maria
authors.initials: OM
authors.lastname: Dragostin
authors.affiliation: Laboratory of General Biochemistry and Physical Pharmacy, Centre for Nano- and Biophotonics, Ghent University, Ottergemsesteenweg 460, Ghent 9000, Belgium. sksamalrec@gmail.com.
authors.forename: Sangram Keshari
authors.initials: SK
authors.lastname: Samal
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 16 University Street, Iasi 700115, Romania. florentina-geanina.l@umfiasi.ro.
authors.forename: Florentina
authors.initials: F
authors.lastname: Lupascu
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 16 University Street, Iasi 700115, Romania. andreea.panzariu@umfiasi.ro.
authors.forename: Andreea
authors.initials: A
authors.lastname: Pânzariu
authors.affiliation: Polymer Chemistry &amp; Biomaterials Research Group, Ghent University, Krijgslaan 281, S4-Bis, Ghent 9000, Belgium. peter.dubruel@ugent.be.
authors.forename: Peter
authors.initials: P
authors.lastname: Dubruel
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 16 University Street, Iasi 700115, Romania. dan.lupascu@umfiasi.ro.
authors.forename: Dan
authors.initials: D
authors.lastname: Lupascu
authors.affiliation: Department of Microbiology, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 16 University Street, Iasi 700115, Romania. cristina.tuchilus@umfiasi.ro.
authors.forename: Cristina
authors.initials: C
authors.lastname: Tuchilus
authors.affiliation: Department of Physical Chemistry of Polymers, "Petru Poni" Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, Iasi 700487, Romania. cvasile@icmpp.ro.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Vasile
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 16 University Street, Iasi 700115, Romania. lenuta.profire@umfiasi.ro.
authors.forename: Lenuta
authors.initials: L
authors.lastname: Profire
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D001458:Bandages; D001713:Biphenyl Compounds / Q000737:chemistry; D048271:Chitosan / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry; D007091:Image Processing, Computer-Assisted; D008826:Microbial Sensitivity Tests; D018625:Microscopy, Atomic Force; D010084:Oxidation-Reduction; D010851:Picrates / Q000737:chemistry; D013449:Sulfonamides / Q000494:pharmacology*; D013499:Surface Properties; D014867:Water / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D013449:Sulfonamides; D014867:Water; D048271:Chitosan; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: antioxidant effects; biodegradation; film; sulfonamide-chitosan derivatives; swelling ratio