title: Combination Chemotherapy of Oxaliplatin and Capecitabine in Patients with Metastatic Colorectal Cancer: a Pilot Study.
abstract: OBJECTIVE
  To evaluate the efficacy and toxicity of oxaliplatin and capecitabine in patients with metastatic colorectal cancer.
  
  
  METHODS
  Between December 2001 and April 2003, fourteen patients were enrolled in this study. Oxaliplatin, 80 mg/m(2), was administered intravenously on day 1, and capecitabine, 1, 250 mg/m(2) bid po (total daily dose 2, 500 mg/m(2)), was given on days 1~14 of 3 week cycles.
  
  
  RESULTS
  The median age of the patients was 57 years (range: 41~74), and the most common sites of metastasis were liver, lung or lymph node. Of the 12 evaluable patients, the overall response rate was 41.7%, but with no complete response. The median response duration and median progression free survival of 12 patients were 42 and 24.4 weeks, respectively. The median overall survival was not reached. A median 6 (range: 1~9), and a total 80, cycles were administered to 14 patients. 80 cycles were evaluable for toxicity. The most common hematological toxicities were NCI grades I/II anemia (45%), leucopenia (33.75%) and thrombocytopenia (17.5%). The most common non-hematological toxicities were nausea/ vomiting (28.75/5%) and neurotoxicity (8.75%). Hand and foot syndrome was noted in only 3.75%. There was no life-threatening toxicity.
  
  
  CONCLUSIONS
  Oxaliplatin and oral capecitabine combination chemotherapy showed significant activity and favorable toxicity in patients with metastatic colorectal cancer. Further studies, with larger numbers of patients and long-tern follow-up will be needed.
authors.forename: Myung Ju
authors.initials: MJ
authors.lastname: Ahn
authors.forename: Ho Suck
authors.initials: HS
authors.lastname: Oh
authors.forename: Jung Hye
authors.initials: JH
authors.lastname: Choi
authors.forename: Young Yeul
authors.initials: YY
authors.lastname: Lee
authors.forename: In Soon
authors.initials: IS
authors.lastname: Kim
authors.forename: Il Young
authors.initials: IY
authors.lastname: Choi
authors.forename: Oh Young
authors.initials: OY
authors.lastname: Lee
authors.forename: Heung Woo
authors.initials: HW
authors.lastname: Lee
keywords: Capecitabine; Chemotherapy; Colorectal neoplasm; Oxaliplatin