title: Assessment of Estradiol Response after Depot Triptorelin Administration in Girls with Central Precocious Puberty.
abstract: BACKGROUND
  Estradiol at baseline or after a classical gonadotropin-releasing hormone test did not reflect ovarian steroidogenesis in central precocious puberty (CPP) girls.
  
  
  OBJECTIVE
  To evaluate estradiol response to depot triptorelin, both at start and during therapy to determine how active ovarian steroidogenesis is at pubertal stage and under therapy.
  
  
  METHODS
  A prospective study was performed in 43 CPP girls. Serum luteinizing hormone and follicle-stimulating hormone at 3 h (LH-3h, FSH-3h) and estradiol at 24 h (E2-24h) after injection of depot triptorelin 3.75 mg were measured, at first dose and at 3, 6, 12, 18 and 24 months of treatment.
  
  
  RESULTS
  E2-24h after depot triptorelin was >100 pg/ml after the first dose. Estradiol response (E2-24h) fell to levels <14 pg/ml in 78 out of 82 follow-up visits along 2 years of therapy. Concomitantly, LH-3h and FSH-3h were <4.0 and <6.3 IU/l, respectively. In 4 patients with inadequate treatment, E2-24h, LH-3h and FSH-3h rose to pubertal values similar to those observed at first dose.
  
  
  CONCLUSIONS
  Estradiol (<14 pg/ml) assessment 24 h after depot triptorelin administration is a reliable and simple manner to confirm ovarian suppression in CPP girls during treatment.
authors.affiliation: Centro de Investigaciones Endocrinolx00F3;gicas x2018;Dr. Cx00E9;sar Bergadx00E1;' (CEDIE), CONICET - FEI - Divisix00F3;n de Endocrinologx00ED;a, Hospital de Nix00F1;os x2018;Ricardo Gutix00E9;rrez', Buenos Aires, Argentina.
authors.forename: Analía Verónica
authors.initials: AV
authors.lastname: Freire
authors.forename: Mirta Graciela
authors.initials: MG
authors.lastname: Gryngarten
authors.forename: María Gabriela
authors.initials: MG
authors.lastname: Ballerini
authors.forename: Andrea Josefina
authors.initials: AJ
authors.lastname: Arcari
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Escobar
authors.forename: Ignacio
authors.initials: I
authors.lastname: Bergadá
authors.forename: María Gabriela
authors.initials: MG
authors.lastname: Ropelato
mesh_terms: D002648:Child; D004958:Estradiol / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011446:Prospective Studies; D011629:Puberty, Precocious / Q000097:blood* / Q000188:drug therapy*; D017329:Triptorelin Pamoate / Q000008:administration & dosage*
chemical_list: D017329:Triptorelin Pamoate; D004958:Estradiol