title: Effect of postoperative proton pump inhibitor therapy on voice outcomes following phonomicrosurgery for vocal fold polyp: a randomized controlled study.
abstract: OBJECTIVE
  To determine the effect of a postoperative proton pump inhibitor (PPI) on voice outcomes after phonomicrosurgery in patients with vocal fold polyp.
  
  
  METHODS
  This is a prospective, randomized controlled study.
  
  
  METHODS
  This study was carried out in a tertiary care referral medical centre.
  
  
  METHODS
  A total of 48 patients underwent phonomicrosurgery for vocal fold polyps. After surgery, patients were randomized to the PPI group (lansoprazole 15 mg twice daily for 2 months) and the non-PPI group.
  
  
  METHODS
  Voice handicap index (VHI) and perceptual and acoustic voice analysis were evaluated at baseline and 2 months after surgery.
  
  
  RESULTS
  Among 48 enrolled patients, a total of 42 patients [non-PPI group (n = 23), PPI group (n = 19)] completed the study. The VHI, perceptual and most acoustic parameters significantly improved in both groups after surgery. However, there was no significant difference in the per cent of change in those parameters.
  
  
  CONCLUSIONS
  Postoperative PPI treatment did not significantly influence voice outcomes after phonomicrosurgery in patients with vocal fold polyp.
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Y C
authors.initials: YC
authors.lastname: Lee
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: S Y
authors.initials: SY
authors.lastname: Na
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: C W
authors.initials: CW
authors.lastname: Yang
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: S I
authors.initials: SI
authors.lastname: Kim
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Y S
authors.initials: YS
authors.lastname: Byun
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: A R
authors.initials: AR
authors.lastname: Jung
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: I Y
authors.initials: IY
authors.lastname: Ryu
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Y G
authors.initials: YG
authors.lastname: Eun
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D064747:Lansoprazole / Q000627:therapeutic use; D007818:Laryngeal Diseases / Q000601:surgery*; D007828:Laryngoscopy; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D011127:Polyps / Q000601:surgery*; D011182:Postoperative Care; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome; D014827:Vocal Cords; D014833:Voice Quality / Q000187:drug effects
chemical_list: D054328:Proton Pump Inhibitors; D064747:Lansoprazole