title: Major depressive disorder in an adolescent with Turner syndrome: a case report.
abstract: Turner syndrome (TS) is a chromosomal abnormality, of which the presence and impact of coexisting psychiatric morbidity has received little attention. The present report describes an adolescent with mosaic karyotype TS who had major depressive disorder with the predisposing cause of psychosocial burden, and relieved with the treatment of sertraline and complete remission with combined use of estradiol valerate. The report suggests us to pay more attention on the mood disorders in children with TS, especially in adolescents. For treatment aspect, medications for improving the puberty development and short stature should be added to in addition to antidepressants if they had mood disorders.
authors.affiliation: a Department of Pediatrics , Hangzhou First People's Hospital , Hangzhou , Zhejiang Province , China .
authors.forename: Shujiong
authors.initials: S
authors.lastname: Mao
authors.affiliation: b Department of Adolescent Gynecology , The Children's Hospital, Zhejiang University School of Medicine , Hangzhou , Zhejiang Province , China , and.
authors.forename: Liying
authors.initials: L
authors.lastname: Sun
authors.affiliation: c Department of Child Psychology , The Children's Hospital, Zhejiang University School of Medicine , Hangzhou , Zhejiang Province , China.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.affiliation: c Department of Child Psychology , The Children's Hospital, Zhejiang University School of Medicine , Hangzhou , Zhejiang Province , China.
authors.forename: Zhengyan
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: c Department of Child Psychology , The Children's Hospital, Zhejiang University School of Medicine , Hangzhou , Zhejiang Province , China.
authors.forename: Rongwang
authors.initials: R
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D004958:Estradiol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D020280:Sertraline / Q000627:therapeutic use*; D016896:Treatment Outcome; D014424:Turner Syndrome / Q000150:complications* / Q000523:psychology
chemical_list: D000928:Antidepressive Agents; D004958:Estradiol; D020280:Sertraline
keywords: Central nervous system; estrogens; hormone replacement therapy