title: Correlation of coronary plaque characteristics and obstructive stenosis with chronic kidney disease by coronary CT angiography.
abstract: BACKGROUND
  Chronic kidney disease (CKD) is an independent risk factor for cardiovascular events. We evaluated the correlation of coronary plaque characteristics and obstructive stenosis with CKD by coronary computed tomographic angiography (CCTA).
  
  
  METHODS
  We enrolled 491 subjects who were suspected coronary artery disease (CAD) undergoing CCTA. Estimated glomerular filtration rate (eGFR) was calculated by the modification of diet in renal disease (MDRD) equation. Patients were subdivided into four groups based on their eGFR: normal GFR (n=213, eGFR ≥90 mL/min/1.73 m(2)), mild renal insufficiency (n=191, eGFR 60-89 mL/min/1.73 m(2)), moderate renal insufficiency(n=78, eGFR <60 mL/min/1.73 m(2), ≥30 mL/min/1.73 m(2)), and severe renal insufficiency (n=9, eGFR <30 mL/min/1.73 m(2), ≥15 mL/min/1.73 m(2)).
  
  
  RESULTS
  Spearman correlation regression analysis showed that the prevalence of any plaque, calcified plaque (CP), mixed plaque (MP) were positively correlate with CKD (r=0.173, P<0.001; r=0.127, P=0.005; r=0.171, P<0.001), after adjustment for traditional risk factors the prevalence of any plaque and MP were still positively correlate with CKD (r=0.106, P=002; r=0.178, P<0.001). And the prevalence of any stenosis and severe stenosis were positively correlate with CKD (r=0.13, P<0.001; r=0.149, P<0.001), after adjustment for traditional risk factors were still positively correlate with CKD (r=0.134, P=0.003; r=0.174, P<0.001).
  
  
  CONCLUSIONS
  CKD is closely related with occurrence of CAD. CKD patients from mild renal insufficiency to severe renal insufficiency are the risk factors for CAD. More serious renal function impairment will indicates higher risk of coronary plaque, MP and obstructive stenosis.
authors.affiliation: 1 Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China ; 2 Imaging Department, Peking University Shenzhen Hospital, Shenzhen 518036, China.
authors.forename: Chengming
authors.initials: C
authors.lastname: Wang
authors.affiliation: 1 Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China ; 2 Imaging Department, Peking University Shenzhen Hospital, Shenzhen 518036, China.
authors.forename: Guanxun
authors.initials: G
authors.lastname: Cheng
authors.affiliation: 1 Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China ; 2 Imaging Department, Peking University Shenzhen Hospital, Shenzhen 518036, China.
authors.forename: Yibo
authors.initials: Y
authors.lastname: Duanmu
authors.affiliation: 1 Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China ; 2 Imaging Department, Peking University Shenzhen Hospital, Shenzhen 518036, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: 1 Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China ; 2 Imaging Department, Peking University Shenzhen Hospital, Shenzhen 518036, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Xu
keywords: Chronic kidney disease (CKD); coronary artery disease (CAD); coronary computed tomographic angiography (CCTA)