title: Can Aliskiren be Considered as a New Novel Drug for Hypertension?
abstract: Hypertension is one of the most common causes of death across the globe. Many trials and drugs have been used for controlling the debilitating effects of hypertension. One such new class of drug is direct renin inhibitors (DRI), e.g., aliskiren, which block the renin-angiotensin system (RAS). It blocks the very first step in the RAS system. Multiple trials have been carried out debating the outcome of monotherapy and combination therapy with other classes of hypertensive drugs. Focus on compliance, adverse effects, and the cost have also been in the news. Extensive studies are still needed to justify the clinical use of a DRI in the effective treatment of hypertension.
authors.affiliation: Department of Medicine, Capital Development Authority Hospital, Islamabad, Pakistan.
authors.forename: Adnan Bashir
authors.initials: AB
authors.lastname: Bhatti
authors.affiliation: Research Fellow, MITR Hospital, Kharghar, Navi Mumbai, Maharashtra, India.
authors.forename: Zarine Anwar
authors.initials: ZA
authors.lastname: Gazali
keywords: aliskerin; angiotensin converting enzyme; angiotensin receptor blockade; hypertension