title: Dapsone hypersensitivity syndrome not related to G6PD deficiency.
abstract: Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. We describe a 55-year-old Caucasian woman with normal glucose-6-phosphate dehydrogenase levels presenting with an extensive skin eruption, high-grade fever, pneumonitis and hepatitis, which occurred within 3 weeks after initiation of dapsone. In addition to supportive care, the patient was successfully treated with high-dose corticosteroids and antibiotics. The combination of high-grade fever, skin rash, lung and liver involvement made a dapsone hypersensitivity syndrome very likely.
authors.affiliation: Department of Internal Medicine, Diakonessenhuis Utrecht, Utrecht, The Netherlands.
authors.forename: Karlijn J G
authors.initials: KJ
authors.lastname: Schulkes
authors.affiliation: Department of Immunology, Maastricht University, Maastricht, The Netherlands.
authors.forename: J W Cohen
authors.initials: JW
authors.lastname: Tervaert
authors.affiliation: Department of Dermatology, Diakonessenhuis Utrecht, Utrecht, The Netherlands.
authors.forename: Feiko
authors.initials: F
authors.lastname: Rijken
authors.affiliation: Department of Intensive Care, Diakonessenhuis Utrecht, Utrecht, The Netherlands.
authors.forename: Lenneke E M
authors.initials: LE
authors.lastname: Haas
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D003622:Dapsone / Q000009:adverse effects*; D003937:Diagnosis, Differential; D063926:Drug Hypersensitivity Syndrome / Q000209:etiology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D005955:Glucosephosphate Dehydrogenase Deficiency; D006801:Humans; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced; D014657:Vasculitis / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D003622:Dapsone; D005954:Glucosephosphate Dehydrogenase