title: The relationship between the neutrophil-lymphocyte ratio and disease activity in patients with ulcerative colitis.
abstract: Preliminary evidence suggests that a higher neutrophil-lymphocyte ratio (NLR) may be an indicator of active ulcerative colitis (UC). However, it is not clear whether the NLR is a useful and simple indicator of clinical activity in UC after adjusting for the other inflammatory markers. We designed a retrospective study to evaluate the role of the NLR in estimating disease severity in UC patients. The study consisted of 71 patients with UC and 140 age- and sex-matched healthy individuals (control group). The NLR, erythrocyte sedimentation rate, C-reactive protein, and white blood cell count were measured. The NLR values of the active UC group were elevated compared with those of the patients with inactive UC and the controls (2.59 ± 1.47, 2.03 ± 1.07, and 1.98 ± 0.85, respectively; p = 0.005). The receiver operating characteristic revealed that the optimum NLR cut-off point for active UC was 2.39. A multivariable logistic analysis showed that of the parameters studied, C-reactive protein was the only parameter able to significantly discriminate active from inactive UC (B: 0.222; p = 0.017; odds ratio: 1.248; 95% confidence interval: 1.041-1.497).
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
authors.forename: Ayse Kevser
authors.initials: AK
authors.lastname: Demir
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Demirtas
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
authors.forename: Suheyla Uzun
authors.initials: SU
authors.lastname: Kaya
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Tastan
authors.affiliation: Department of Biochemistry, Gaziosmanpasa University Faculty of Medicine, Tokat, Turkey.
authors.forename: Ilknur
authors.initials: I
authors.lastname: Butun
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sagcan
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey. Electronic address: drsafaksahin@gmail.com.
authors.forename: Safak
authors.initials: S
authors.lastname: Sahin
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
authors.forename: Turker
authors.initials: T
authors.lastname: Tasliyurt
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
authors.forename: Abdulkerim
authors.initials: A
authors.lastname: Yilmaz
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000097:blood* / Q000175:diagnosis; D003710:Demography; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007958:Leukocyte Count; D016015:Logistic Models; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils / Q000473:pathology*
chemical_list: D015415:Biomarkers
keywords: C-reactive protein; Disease activation; Erythrocyte sedimentation rate; Neutrophil lymphocyte ratio; Ulcerative colitis