title: Synthesis, characterization and bioevaluation of drug-collagen hybrid materials for biomedical applications.
abstract: This work presents a study based on the preparation and characterization of drug-collagen hybrid materials. Materials used for obtaining drug-collagen hybrids were collagen type I (Coll) as matrix and fludarabine (F) and epirubicin (E) as hydrophilic active substances. After incorporation of drugs into Coll in different ratios, the obtained hybrid materials (Coll/F and Coll/E) could be used according to our results as potential drug delivery systems in medicine for the topical (local) treatment of cancerous tissues (e.g. the treatment of breast, stomach, lung, colorectal or advanced ovarian cancer). The materials were characterized considering their composition (by XRD, FT-IR and DTA-TG) and their morphology (by SEM). The delivery of drug was assessed by UV-vis. The in vitro citotoxicity demonstrates an antitumoral activity of the obtained hybrid materials and their potential use for biomedical applications as drug delivery systems in tumoral treatments.
authors.affiliation: Politehnica University of Bucharest, Faculty of Applied Chemistry and Material Science; 1-7 Gh Polizu Str., 011061 Bucharest, Romania.
authors.forename: Georgeta
authors.initials: G
authors.lastname: Voicu
authors.affiliation: Politehnica University of Bucharest, Faculty of Applied Chemistry and Material Science; 1-7 Gh Polizu Str., 011061 Bucharest, Romania. Electronic address: ruxandra_geanaliu@yahoo.com.
authors.forename: Ruxandra-Elena
authors.initials: RE
authors.lastname: Geanaliu-Nicolae
authors.affiliation: Politehnica University of Bucharest, Faculty of Applied Chemistry and Material Science; 1-7 Gh Polizu Str., 011061 Bucharest, Romania.
authors.forename: Adrian-Alexandru
authors.initials: AA
authors.lastname: Pîrvan
authors.affiliation: Politehnica University of Bucharest, Faculty of Applied Chemistry and Material Science; 1-7 Gh Polizu Str., 011061 Bucharest, Romania.
authors.forename: Ecaterina
authors.initials: E
authors.lastname: Andronescu
authors.affiliation: Institute of Cellular Biology and Pathology of Romanian Academy, "Nicolae Simionescu", Department of Fetal and Adult Stem Cell Therapy, 8, B.P. Hasdeu, Bucharest 050568, Romania.
authors.forename: Florin
authors.initials: F
authors.lastname: Iordache
mesh_terms: D024042:Collagen Type I / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D015251:Epirubicin / Q000737:chemistry; D006801:Humans; D008422:Materials Testing / Q000379:methods; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D014740:Vidarabine / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D024042:Collagen Type I; D004364:Pharmaceutical Preparations; D015251:Epirubicin; D014740:Vidarabine; C024352:fludarabine
keywords: Cancer treatment; Collagen; Drug delivery systems; Epirubicin; Fludarabine; Hybrid materials