title: Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon.
abstract: There has been an unprecedented worldwide rise in non-communicable metabolic diseases (NCDs), particularly cardiovascular diseases (CVD) and diabetes. While modern pharmacotherapy has decreased the mortality in the existing population, it has failed to stem the rise. Furthermore, a large segment of the world population cannot afford expensive pharmacotherapy. Therefore, there is an urgent need for inexpensive preventive measures to control the rise in CVD and diabetes and associated co-morbidities. The purpose of this review is to explore the role of food bioactives in prevention of NCDs. To this end, we have critically analyzed the possible utility of three classes of food bioactives: (a) resistant starch, a metabolically resistant carbohydrate known to favorably modulate insulin secretion and glucose metabolism; (b) cyclo (His-Pro), a food-derived cyclic dipeptides; and (c) polyphenol-rich berries. Finally, we have also briefly outlined the strategies needed to prepare these food-bioactives for human use.
authors.affiliation: Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA. cprasad@twu.edu.|Department of Medicine, LSU Health Sciences Center, New Orleans, LA 70112, USA. cprasad@twu.edu.
authors.forename: Chandan
authors.initials: C
authors.lastname: Prasad
authors.affiliation: Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA. Vimrhan@twu.edu.
authors.forename: Victorine
authors.initials: V
authors.lastname: Imrhan
authors.affiliation: Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA. sjuma@twu.edu.
authors.forename: Shanil
authors.initials: S
authors.lastname: Juma
authors.affiliation: Department of Nutrition and Food Sciences, Texas Woman's University, Houston, TX 77030, USA. Mmaziarz@twu.edu.
authors.forename: Mindy
authors.initials: M
authors.lastname: Maziarz
authors.affiliation: Department of Medicine, Division of Cardiology, UT Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. Prasada@uthscsa.edu.
authors.forename: Anand
authors.initials: A
authors.lastname: Prasad
authors.affiliation: Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA. CTiernan@twu.edu.
authors.forename: Casey
authors.initials: C
authors.lastname: Tiernan
authors.affiliation: Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA. pvijayagopal@twu.edu.
authors.forename: Parakat
authors.initials: P
authors.lastname: Vijayagopal
keywords: cardiovascular disease; cyclo (His-Pro); diabetes; food bioactives; functional food; polyphenols; resistant starch