title: [Optimization of dry granulating technique of Qibai Pingfei granule through response surface methodology].
abstract: To determine the optimum process conditions for dry granulating technique of Qibai Pingfei granule, granule excipient type, rolling wheel speed and pressure and feeding speed were studied. Taking shaping rate at a time, moisture absorption and dissolubility as index, the type and amount of granule excipient were determined. In addition, taking shaping rate at a time as index, parameters of rolling wheel speed and pressure and feeding speed were researched through single factor test and response surface methodology. The optimum parameters were as follows: lactose as excipient, dry extract powder to excipient at 1:2, rolling wheel speed and pressure at 10.9 Hz and 6.4 MPa and feeding speed at 7.2 Hz. After validation of three batches pilot-scale production, the optimum processing parameters for dry granulating technique of Qibai Pingfei granule is reasonable and feasible, which can provide reliable basis for production.
authors.forename: Xue-feng
authors.initials: XF
authors.lastname: Li
authors.forename: Yun-xiao
authors.initials: YX
authors.lastname: Li
authors.forename: Zhen-qiu
authors.initials: ZQ
authors.lastname: Xu
authors.forename: Jin
authors.initials: J
authors.lastname: Meng
authors.forename: Ming
authors.initials: M
authors.lastname: Yan
authors.forename: Rui-ting
authors.initials: RT
authors.lastname: Jin
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
mesh_terms: D004365:Drugs, Chinese Herbal; D011208:Powders; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004365:Drugs, Chinese Herbal; D011208:Powders