title: Polyketide butenolide, diphenyl ether, and benzophenone derivatives from the fungus Aspergillus flavipes PJ03-11.
abstract: Five new polyketides including three new butenolides (1-3), one new diphenyl ether (4), and one new benzophenone (5), together with eleven known compounds (6-16) were isolated from a wetland fungus Aspergillus flavipes PJ03-11. Their structures were elucidated on the basis of detailed spectroscopic analysis. All the isolated compounds were tested for their α-glucosidase inhibitory activities. The results showed that compounds 1-3, 6, 7, 11, 15 and 16 exhibited stronger inhibitory activities than acarbose. And the preliminary structure-activity relationships of aspulvinone and diphenyl ether compounds on the α-glucosidase inhibitory activity were reported.
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Zhang
authors.affiliation: School of Life Sciences and Biotechnology, Dalian University, Dalian 116622, China.
authors.forename: Bao-Min
authors.initials: BM
authors.lastname: Feng
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Yu-Qing
authors.initials: YQ
authors.lastname: Zhao
authors.affiliation: Institute of Chinese MateriaMedica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Bai
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Hua
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: wanghaifeng0310@163.com.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Wang
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese MateriaMedica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: peiyueh@vip.163.com.
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Pei
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D001577:Benzophenones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010647:Phenyl Ethers / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D061065:Polyketides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D001577:Benzophenones; D065089:Glycoside Hydrolase Inhibitors; D010647:Phenyl Ethers; D061065:Polyketides; C031538:phenyl ether; C047723:benzophenone; C004511:butenolide; D000520:alpha-Glucosidases; D015107:4-Butyrolactone
keywords: Aspergillus flavipes; Benzophenone; Butenolide; Diphenyl ether; Polyketide; α-Glucosidase