title: Type 1 Retinopathy of Prematurity and Its Laser Treatment of Large Preterm Infants in East China.
abstract: OBJECTIVE
  To describe Type 1 retinopathy of prematurity (ROP) and its laser treatment outcomes in premature infants with birth weight > 1250 g in Eastern China.
  
  
  METHODS
  A retrospective review of 3175 ROP records was conducted at Shanghai Eye & ENT Hospital of Fudan University. The records were collected at the ROP clinic from 2006 to 2014, including their demographic and medical information such as gestational age, birth weight, supplemental oxygen therapy, systemic complications, ROP stage, location, presence of plus disease. All infants were examined by RetCam fundus camera. Those with Type 1 ROP were also examined by indirect ophthalmoscope before undergoing transpupillary laser treatment.
  
  
  RESULTS
  A total of 12 infants (24 eyes) with Type 1 ROP and birth weight > 1250 g were enrolled. All infants enrolled had plus disease and ROP in zone II retina. Specifically, 16 eyes (67%) had stage 2 ROP. 8 eyes (33%) had stage 3 ROP. ROP regressed in 23 eyes (96%) following laser treatment. Partial retinal detachment developed in one eye (4%). No severe involution sequelaes or laser-related complications were recorded. Mean follow-up was 30±6 weeks.
  
  
  CONCLUSIONS
  Type 1 ROP may occur in large premature infants who have undergone supplemental oxygen therapy. This Type 1 ROP is mainly located in zone II retina. Laser treatment is a safe and effective intervention for these infants.
authors.affiliation: Department of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.|Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China.|Department of Ophthalmology, Kashgar Prefecture Second People's Hospital, Xinjiang 844000, China.
authors.forename: Haidong
authors.initials: H
authors.lastname: Shan
authors.affiliation: Department of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.|Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China.
authors.forename: Yinqing
authors.initials: Y
authors.lastname: Ni
authors.affiliation: Department of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.|Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Xue
authors.affiliation: Department of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.|Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.|Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
mesh_terms: D002681:China; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007234:Infant, Premature; D053685:Laser Therapy / Q000379:methods; D008297:Male; D012178:Retinopathy of Prematurity / Q000175:diagnosis / Q000628:therapy*; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome