title: The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases.
abstract: The triggering receptor expressed on myeloid cells (TREM) 2 is a member of the immunoglobulin superfamily of receptors and mediates signaling in immune cells via engagement of its co-receptor DNAX-activating protein of 12 kDa (DAP12). Homozygous mutations in TREM2 or DAP12 cause Nasu-Hakola disease, which is characterized by bone abnormalities and dementia. Recently, a variant of TREM2 has also been associated with an increased risk for Alzheimer disease. The selective expression of TREM2 on immune cells and its association with different forms of dementia indicate a contribution of this receptor in common pathways of neurodegeneration.
authors.affiliation: From the Department of Neurology, University of Bonn, 53127 Bonn, Germany jochen.walter@ukb.uni-bonn.de.
authors.forename: Jochen
authors.identifier: http://orcid.org/0000-0002-4678-2912
authors.initials: J
authors.lastname: Walter
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D000818:Animals; D006801:Humans; D008060:Lipodystrophy / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D017628:Microglia / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008954:Models, Biological; D009154:Mutation; D022423:Myeloid Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D010009:Osteochondrodysplasias / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D011971:Receptors, Immunologic / Q000235:genetics / Q000378:metabolism*; D013344:Subacute Sclerosing Panencephalitis / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; C498715:TREM2 protein, human; C110546:TYROBP protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
keywords: Alzheimer disease; cell signaling; microglia; neurodegenerative disease; neuroinflammation; protein processing