title: Shear Stress Metrics and Their Relation to Atherosclerosis: An In Vivo Follow-up Study in Atherosclerotic Mice.
abstract: It is generally accepted that low and oscillatory wall shear stress favors the initiation and development of atherosclerosis. However, a quantitative analysis of the association between shear stress metrics at baseline and lesion prevalence at a later stage is challenging to perform in vivo on a within-subject basis. In this study, we assessed carotid hemodynamics and derived hemodynamic wall parameters from subject-specific fluid-structure interaction simulations in the left and right carotid arteries of 4 ApoE(-/-) mice prior to disease development. We then applied a point-by-point quantitative association (surrogate sample data analysis) between various established and more recent shear related parameters and the extent of macrophage infiltration at a later stage. We conclude that, for the atherosclerotic murine carotid bifurcation, (i) there is an association between hemodynamics and macrophage infiltration; (ii) this correlation is most apparent when assessed at the level of the entire carotid bifurcation; (iii) the strongest spatial correlation between hemodynamics and atherosclerosis development was found for the time averaged wall shear stress (negative correlation) and the relative residence time (positive correlation); (iv) aggregating the data leads to an overestimation of the correlation.
authors.affiliation: IBiTech-bioMMeda, iMinds Medical IT, Ghent University, Ghent, Belgium. david.dewilde@ugent.be.|bioMMeda, De Pintelaan185-blokB5, 9000, Ghent, Belgium. david.dewilde@ugent.be.
authors.forename: David
authors.identifier: http://orcid.org/0000-0003-4175-8144
authors.initials: D
authors.lastname: De Wilde
authors.affiliation: IBiTech-bioMMeda, iMinds Medical IT, Ghent University, Ghent, Belgium.|Institute for Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: Bram
authors.initials: B
authors.lastname: Trachet
authors.affiliation: Division of Physiopharmacology, University of Antwerp, Antwerp, Belgium.
authors.forename: Guido R Y
authors.initials: GRY
authors.lastname: De Meyer
authors.affiliation: IBiTech-bioMMeda, iMinds Medical IT, Ghent University, Ghent, Belgium.
authors.forename: Patrick
authors.initials: P
authors.lastname: Segers
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency; D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D002339:Carotid Arteries / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D006439:Hemodynamics; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D008955:Models, Cardiovascular; D033081:Shear Strength; D013314:Stress, Mechanical
chemical_list: D001057:Apolipoproteins E
keywords: Atherosclerosis; CT; Fluid–structure interaction; Hemodynamics; Mouse models; Wall shear stress