title: A Mixture of Ethanol Extracts of Persimmon Leaf and Citrus junos Sieb Improves Blood Coagulation Parameters and Ameliorates Lipid Metabolism Disturbances Caused by Diet-Induced Obesity in C57BL/6J Mice.
abstract: This study investigated the effects of a flavonoid-rich ethanol extract of persimmon leaf (PL), an ethanol extract of Citrus junos Sieb (CJS), and a PL-CJS mixture (MPC) on mice fed a highfat diet (HFD). We sought to elucidate the mechanisms of biological activity of these substances using measurements of blood coagulation indices and lipid metabolism parameters. C57BL/6J mice were fed a HFD with PL (0.5% (w/w)), CJS (0.1% (w/w)), or MPC (PL 0.5%, CJS 0.1% (w/w)) for 10 weeks. In comparison with data obtained for mice in the untreated HFD group, consumption of MPC remarkably prolonged the activated partial thromboplastin time (aPTT) and prothrombin time (PT), whereas exposure to PL prolonged aPTT only. Lower levels of plasma total cholesterol, hepatic cholesterol, and erythrocyte thiobarbituric acid-reactive substances, hepatic HMG-CoA reductase, and decreased SREBP-1c gene expression were observed in mice that received PL and MPC supplements compared with the respective values detected in the untreated HFD animals. Our results indicate that PL and MPC may have beneficial effects on blood circulation and lipid metabolism in obese mice.
authors.affiliation: Department of Food Science and Nutrition, Kyungpook National University, Daegu 41566, Republic of Korea.
authors.forename: Ae Hyang
authors.initials: AH
authors.lastname: Kim
authors.affiliation: Food R&D, CJ CheilJedang Corporation, Seoul 16395, Republic of Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Food Science and Nutrition, Kyungpook National University, Daegu 41566, Republic of Korea.
authors.forename: Ri
authors.initials: R
authors.lastname: Ryu
authors.affiliation: Department of Food Science and Nutrition, Kyungpook National University, Daegu 41566, Republic of Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Han
authors.affiliation: Department of Food Science and Nutrition, Kyungpook National University, Daegu 41566, Republic of Korea.
authors.forename: Young Ji
authors.initials: YJ
authors.lastname: Han
authors.affiliation: Department of Food and Nutrition, Suncheon National University, Suncheon 57922, Republic of Korea.
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Lee
authors.affiliation: Department of Food Science and Nutrition, Kyungpook National University, Daegu 41566, Republic of Korea.|Center for Food Nutritional Genomics Research, Kyungpook National University, Daegu 41566, Republic of Korea.
authors.forename: Myung-Sook
authors.initials: MS
authors.lastname: Choi
authors.affiliation: School of Life Sciences and Biotechnology, Kyungpook National University, Daegu 41566, Republic of Korea.
authors.forename: Yong Bok
authors.initials: YB
authors.lastname: Park
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D001777:Blood Coagulation / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D002957:Citrus / Q000737:chemistry*; D059305:Diet, High-Fat; D029788:Diospyros / Q000737:chemistry*; D000431:Ethanol; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000033:anatomy & histology; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D011516:Prothrombin; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics; D013925:Thromboplastin; D014280:Triglycerides
chemical_list: D000924:Anticholesteremic Agents; D010936:Plant Extracts; D051780:Sterol Regulatory Element Binding Protein 1; D014280:Triglycerides; D000431:Ethanol; D011516:Prothrombin; D013925:Thromboplastin; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases
keywords: Citrus junos Sieb; blood circulation; lipid metabolism; obesity; persimmon leaf