title: Target-selective photo-degradation of AFP-L3 and selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells using an anthraquinone-PhoSL hybrid.
abstract: A purposefully-designed anthraquinone-Pholiota squarrosa lectin (PhoSL) hybrid effectively degraded α-fetoprotein-L3 (AFP-L3) associated with liver cancer. Degradation was achieved under light irradiation in the absence of any additives and under neutral pH conditions. Moreover, the hybrid effectively exhibited selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells upon photo-irradiation.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. toshima@applc.keio.ac.jp.
authors.forename: Mai
authors.initials: M
authors.lastname: Okuyama
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. toshima@applc.keio.ac.jp.
authors.forename: Haruna
authors.initials: H
authors.lastname: Ueno
authors.affiliation: J-Oil Mills, Inc., Yokohama 245-0064, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: Research Institute of Green Science and Technology, Shizuoka University, Shizuoka 422-8529, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kawagishi
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. toshima@applc.keio.ac.jp.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takahashi
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. toshima@applc.keio.ac.jp.
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Toshima
mesh_terms: D000880:Anthraquinones / Q000737:chemistry*; D006528:Carcinoma, Hepatocellular / Q000737:chemistry* / Q000378:metabolism; D045744:Cell Line, Tumor; D005326:Fetal Proteins / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D037102:Lectins / Q000737:chemistry* / Q000378:metabolism; D008113:Liver Neoplasms / Q000737:chemistry* / Q000378:metabolism*; D008969:Molecular Sequence Data; D055368:Pholiota / Q000737:chemistry* / Q000378:metabolism; D010782:Photolysis; D011485:Protein Binding
chemical_list: D000880:Anthraquinones; D005326:Fetal Proteins; D037102:Lectins