title: Single nucleotide polymorphisms in DKK3 gene are associated with prostate cancer risk and progression.
abstract: We had investigated whether sequence variants within DKK3 gene are associated with the development of prostate cancer in a Korean study cohort. We evaluated the association between 53 single nucleotide polymorphisms (SNPs) in the DKK3 gene and prostate cancer risk as well as clinical characteristics (PSA, clinical stage, pathological stage and Gleason score) in Korean men (272 prostate cancer subjects and 173 benign prostate hyperplasia subjects) using unconditional logistic regression analysis. Of the 53 SNPs and 25 common haplotypes, 5 SNPs and 4 haplotypes were associated with prostate cancer risk (P=0.02-0.04); 3 SNPs and 2 haplotypes were significantly associated with susceptibility to prostate cancer, however 2 SNPs and 2 haplotypes exhibited a significant protective effect on prostate cancer. Logistic analyses of the DKK3 gene polymorphisms with several prostate cancer related factors showed that several SNPs were significant; three SNPs and two haplotypes to PSA level, three SNPs and two haplotypes to clinical stage, nine SNPs and two haplotype to pathological stage, one SNP and one haplotypes to Gleason score. To the author's knowledge, this is the first report documenting that DKK3 polymorphisms are not only associated with prostate cancer but also related to prostate cancer-related factors.
authors.affiliation: Department of Urology, Seoul Medical Center, Seoul, Korea.
authors.forename: Min Su
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Urology, Seoul Seonam Hospital, EwhaWomans University, Seoul, Korea.
authors.forename: Ha Na
authors.initials: HN
authors.lastname: Lee
authors.affiliation: Research Institue for Biomedical and Pharmaceutical Sciences, Chung-Ang University, Seoul, Korea.|Advanced Urogenital Diseas Research Center, Chung-Ang University, College of Medicine, Seoul, Korea.
authors.forename: Hae Jong
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Urology, Chung-Ang University, College of Medicine, Seoul, Korea.
authors.forename: Soon Chul
authors.initials: SC
authors.lastname: Myung
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D018925:Chemokines; D015331:Cohort Studies; D018450:Disease Progression; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D012016:Reference Values; D012044:Regression Analysis; D012307:Risk Factors; D066106:Seoul
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018925:Chemokines; C498624:DKK3 protein, human; D005819:Genetic Markers; D036341:Intercellular Signaling Peptides and Proteins