title: A predictive signature for therapy assignment and risk assessment in prostate cancer.
abstract: Prostate cancer remains the second leading cause of death in men. It is imperative to improve patient management in identifying bio-markers for personalized treatment. We demonstrated miR-15/miR-16 loss and miR-21 up-regulation and deregulation of their target genes, which represent a promising signature for ameliorating therapy assignment and risk assessment in prostate cancer.
authors.affiliation: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy ; Scientific Directorate, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Désirée
authors.initials: D
authors.lastname: Bonci
authors.affiliation: Scientific Directorate, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: Ruggero
authors.initials: R
authors.lastname: De Maria
keywords: genes; miRNA; non-coding RNA; prostrate cancer