title: Cytokine and viral load kinetics in human herpesvirus 8-associated multicentric Castleman's disease complicated by hemophagocytic lymphohistiocytosis.
abstract: Human herpes virus 8 (HHV-8)-associated secondary hemophagocytic lymphohistiocytosis is a rare but critical immuno-hematological entity in immunocompetent patients. Establishing a diagnosis is challenging as is the monitoring of disease activity and therapeutic effects. We report a case of a HHV-8-associated hemophagocytic lymphohistiocytosis in a HIV-negative adult patient with multicentric Castleman's disease. As a novel finding, we report the use of certain inflammatory parameters, primarily interleukin-10 combined with viral load monitoring of the causative infectious agent in this case HHV-8 to monitor the clinical course of the hemophagocytic lymphohistiocytosis in the setting of bacterial septic complications.
authors.affiliation: Section of Clinical Immunology, Department of Internal Medicine, Erasmus University MC, University Medical Center, Room D-419, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
authors.forename: Timo C E
authors.initials: TC
authors.lastname: Zondag
authors.affiliation: Section of Infectious Diseases, Department of Internal Medicine, Erasmus University MC, University Medical Center, Rotterdam, The Netherlands.
authors.forename: Casper
authors.initials: C
authors.lastname: Rokx
authors.affiliation: Department of Hematology, Erasmus University MC, University Medical Center, Rotterdam, The Netherlands.
authors.forename: Kirsten
authors.initials: K
authors.lastname: van Lom
authors.affiliation: Department of Hematology, Erasmus University MC, University Medical Center, Rotterdam, The Netherlands.
authors.forename: Arjan R
authors.initials: AR
authors.lastname: van den Berg
authors.affiliation: Department of Hematology, Erasmus University MC, University Medical Center, Rotterdam, The Netherlands.
authors.forename: Pieter
authors.initials: P
authors.lastname: Sonneveld
authors.affiliation: Department of Immunology, Laboratory Medical Immunology, Erasmus University MC, University Medical Center, Rotterdam, The Netherlands.
authors.forename: Willem A
authors.initials: WA
authors.lastname: Dik
authors.affiliation: Department of Virology, Erasmus University MC, University Medical Center, Rotterdam, The Netherlands.
authors.forename: Gerard J J
authors.initials: GJ
authors.lastname: van Doornum
authors.affiliation: Department of Pathology, Erasmus University MC, University Medical Center, Rotterdam, The Netherlands.
authors.forename: King H
authors.initials: KH
authors.lastname: Lam
authors.affiliation: Section of Clinical Immunology, Department of Internal Medicine, Erasmus University MC, University Medical Center, Room D-419, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. j.vanlaar@erasmusmc.nl.|Department of Immunology, Laboratory Medical Immunology, Erasmus University MC, University Medical Center, Rotterdam, The Netherlands. j.vanlaar@erasmusmc.nl.
authors.forename: Jan A M
authors.initials: JA
authors.lastname: van Laar
mesh_terms: D005871:Castleman Disease / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000821:virology; D005260:Female; D006566:Herpesviridae Infections / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000821:virology; D019288:Herpesvirus 8, Human / Q000502:physiology*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000821:virology; D008875:Middle Aged; D019562:Viral Load
chemical_list: D016753:Interleukin-10
keywords: Hemophagocytic lymphohistiocytosis; Human herpes virus 8; Interleukin-10; Multicentric Castleman’s disease