title: Biomechanical characterisation of the human nasal cartilages; implications for tissue engineering.
abstract: Nasal reconstruction is currently performed using autologous grafts provides but is limited by donor site morbidity, tissue availability and potentially graft failure. Additionally, current alternative alloplastic materials are limited by their high extrusion and infection rates. Matching mechanical properties of synthetic materials to the native tissue they are replacing has shown to be important in the biocompatibility of implants. To date the mechanical properties of the human nasal cartilages has not been studied in depth to be able to create tissue-engineered replacements with similar mechanical properties to native tissue. The young's modulus was characterized in compression on fresh-frozen human cadaveric septal, alar, and lateral cartilage. Due to the functional differences experienced by the various aspects of the septal cartilage, 16 regions were evaluated with an average elastic modulus of 2.72 ± 0.63 MPa. Furthermore, the posterior septum was found to be significantly stiffer than the anterior septum (p < 0.01). The medial and lateral alar cartilages were tested at four points with an elastic modulus ranging from 2.09 ± 0.81 MPa, with no significant difference between the cartilages (p < 0.78). The lateral cartilage was tested once in all cadavers with an average elastic modulus of 0.98 ± 0.29 MPa. In conclusion, this study provides new information on the compressive mechanical properties of the human nasal cartilage, allowing surgeons to have a better understanding of the difference between the mechanical properties of the individual nasal cartilages. This study has provided a reference, by which tissue-engineered should be developed for effective cartilage replacements for nasal reconstruction.
authors.affiliation: Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, University College London, London, UK. 12michellegriffin@gmail.com.
authors.forename: M F
authors.initials: MF
authors.lastname: Griffin
authors.affiliation: Anatomical Sciences, Institute for Medical and Biomedical Education, St. George's, University of London, London, UK.
authors.forename: Y
authors.initials: Y
authors.lastname: Premakumar
authors.affiliation: Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, University College London, London, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Seifalian
authors.affiliation: Anatomical Sciences, Institute for Medical and Biomedical Education, St. George's, University of London, London, UK. mszarko@sgul.ac.uk.
authors.forename: M
authors.initials: M
authors.lastname: Szarko
authors.affiliation: Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, University College London, London, UK.|Department of Plastic and Reconstructive Surgery, Royal Free Hampstead NHS Trust Hospital, London, UK.
authors.forename: P E M
authors.initials: PE
authors.lastname: Butler
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D002102:Cadaver; D002356:Cartilage / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D023822:Tissue Engineering