title: Loxapine for Reversal of Antipsychotic-Induced Metabolic Disturbances: A Chart Review.
abstract: Loxapine substitution is a promising option for patients with autism spectrum disorder (ASD) who develop antipsychotic-induced metabolic illness. We performed a chart review of 15 adolescents and adults meeting DSM-IV-TR criteria for ASD, all with antipsychotic-associated weight gain, who received low dose loxapine in an attempt to taper or discontinue the weight gain-associated antipsychotic. Mean weight loss was -5.7 kg, mean BMI reduction was -1.9, and mean triglyceride reduction was -33.7 mg/dl. At chart review, 14 of 15 subjects were rated 2 (Much Improved) or 1 (Very Much Improved) on the Clinical Global Impressions-Improvement scale (CGI-I). Low dose loxapine addition in most cases enabled taper of offending antipsychotics, significantly reversed drug-induced metabolic disturbances and improved irritability.
authors.affiliation: The Ohio State University College of Medicine, 370 W 9th Ave, Columbus, OH, 43210, USA. seema.jain@osumc.edu.
authors.forename: Seema
authors.initials: S
authors.lastname: Jain
authors.affiliation: The Ohio State University College of Public Health, Columbus, OH, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Andridge
authors.affiliation: The Ohio State University Nisonger Center, Columbus, OH, USA.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Hellings
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D000067877:Autism Spectrum Disorder / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007508:Irritable Mood / Q000187:drug effects; D008152:Loxapine / Q000627:therapeutic use*; D008297:Male; D008499:Medical Records; D024821:Metabolic Syndrome / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D008152:Loxapine
keywords: Atypical antipsychotics; Autism spectrum disorder; Loxapine; Metabolic side effects