title: Cryptococcus neoformans var. grubii Infection in HIV-Seronegative Patients from Northeast India: Report of Two Cases with Review of Literature.
abstract: Cryptococcus neoformans infection can occur in a wide range of hosts ranging from those who are severely immunosuppressed to those who are apparently immunocompetent. Two apparently immunocompetent HIV-seronegative patients with cryptococcal meningitis and multiple skin lesions, both due to C. neoformans var. grubii, are reported. Pregnancy was found as an associated factor in cryptococcal meningitis in a 20-year-old female patient from Arunachal Pradesh. Multiple skin lesions were the presenting feature of an 18-year-old male patient from Dibrugarh, eastern Assam. The organism was identified both phenotypically and by sequencing of ITS1 and ITS2 regions of rRNA gene. The cases are reported because of rarity of this infection in non-HIV-infected patients.
authors.affiliation: Department of Microbiology, Assam Medical College and Hospital, Dibrugarh, Assam, 786002, India. reema_44@rediffmail.com.
authors.forename: Reema
authors.initials: R
authors.lastname: Nath
authors.affiliation: Department of Medicine, Assam Medical College and Hospital, Dibrugarh, Assam, 786002, India.
authors.forename: Basanta
authors.initials: B
authors.lastname: Laskar
authors.affiliation: Department of Surgery, Assam Medical College and Hospital, Dibrugarh, Assam, 786002, India.
authors.forename: Jishan
authors.initials: J
authors.lastname: Ahmed
authors.affiliation: Department of Medicine, Assam Medical College and Hospital, Dibrugarh, Assam, 786002, India.
authors.forename: Subhalakshmi
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Microbiology, Assam Medical College and Hospital, Dibrugarh, Assam, 786002, India.
authors.forename: Longminder
authors.initials: L
authors.lastname: Timung
authors.affiliation: Department of Microbiology, Assam Medical College and Hospital, Dibrugarh, Assam, 786002, India.
authors.forename: Lahari
authors.initials: L
authors.lastname: Saikia
mesh_terms: D000293:Adolescent; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D001483:Base Sequence; D003455:Cryptococcus neoformans / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D021901:DNA, Intergenic / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D003881:Dermatomycoses / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D018023:HIV Seronegativity; D006801:Humans; D007194:India; D008297:Male; D016919:Meningitis, Cryptococcal / Q000188:drug therapy* / Q000382:microbiology; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D021901:DNA, Intergenic; D021903:DNA, Ribosomal Spacer; D000666:Amphotericin B; D015725:Fluconazole
keywords: Cryptococcus neoformans var. grubii; Immunocompetent; Pregnancy; Skin infection