title: Antinociceptive effect of palm date spathe hydroalcoholic extract on acute and chronic pain in mice as compared with analgesic effect of morphine and diclofenac.
abstract: BACKGROUND
  In Persian traditional medicine, palm date spathe (PDS) is introduced as an analgesic. Therefore, this study was designed to investigate the analgesic effect of hydroalcoholic extract of PDS on acute and chronic pain in mice in comparison with diclofenac and morphine.
  
  
  METHODS
  In this study, which was conducted in summer 2014, 220 male mice (20-30 g) were randomly divided into two categories, each consists of 11 groups as follows: A normal control group, a solvent (Tween 80) control group, 3 morphine positive control groups (2, 4 and 8 mg/kg), 3 diclofenac positive control groups (10, 20 and 30 mg/kg), and 3 main experimental PDS groups (2, 20, and 200 mg/kg). Hot plate was applied on animals in one category and writing test on the other category to assess acute and chronic pain, respectively.
  
  
  RESULTS
  In the writing test, the average writing time and number of animals receiving a maximum dosage of morphine, diclofenac, and PDS were significantly less than the control group. In the hot plate test, only groups receiving different doses of morphine at different time points and those received 30 mg/kg diclofenac at 15 min after the intervention showed significant difference with the control group.
  
  
  CONCLUSIONS
  200 mg/kg extract of PDS, revealed a significant analgesic effect on chronic pain, but it did not show any analgesic effect on acute pain.
authors.affiliation: Department of Anatomy, Faculty of Medical Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Peyghambari
authors.affiliation: Department of Physiology, Herbal Medicine Research Center, Neurobiomedical Research Center, Yazd, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Dashti-Rahmatabadi
authors.affiliation: Department of Anatomy, Faculty of Medical Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran.
authors.forename: Mansooreh Dehghanfi
authors.initials: MD
authors.lastname: Rozabadi
authors.affiliation: Department of Surgery, Arak University of Medical Sciences and Health Services, Arak, Iran.
authors.forename: Razieh Dehghanfi
authors.initials: RD
authors.lastname: Rozabadi
authors.affiliation: Department of Physiology, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: Fatemeh Dehghanfi
authors.initials: FD
authors.lastname: Rozabadi
authors.affiliation: Department of Psychiatry, Kerman University of Medical Sciences and Health Services, Kerman, Iran.
authors.forename: Mohammadesmaeil
authors.initials: M
authors.lastname: Pangalizadeh
authors.affiliation: Department of Anatomy, Faculty of Medical Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran.
authors.forename: Narges
authors.initials: N
authors.lastname: Dehghanimohammadabadi
keywords: Mic; pain; palm date; phoenix dactylifera; spathe