title: The Multifaceted Roles of PRDM16: Adipose Biology and Beyond.
abstract: The PRDM [PRDI-BFI (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1) homologous domain containing] protein family is involved in a spectrum of biological processes including cell fate determination and development. These proteins regulate transcription through intrinsic chromatin-modifying activity or by complexing with histone-modifying or other nuclear proteins. Studies have indicated crucial roles for PRDM16 in the determination and function of brown and beige fat as well as in hematopoiesis and cardiac development, highlighting the importance of PRDM16 in developmental processes in different tissues. More recently, PRDM16 mutations were also identified in humans. The substantial progress in understanding the mechanism underlying the action of PRDM16 in adipose biology may have relevance to other PRDM family members, and this new knowledge has the potential to be exploited for therapeutic benefit.
authors.affiliation: The Rockefeller University, Laboratory of Molecular Metabolism, New York, NY 10065, USA.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Chi
authors.affiliation: The Rockefeller University, Laboratory of Molecular Metabolism, New York, NY 10065, USA. Electronic address: pcohen@rockefeller.edu.
authors.forename: Paul
authors.initials: P
authors.lastname: Cohen
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism; D052436:Adipose Tissue, White / Q000378:metabolism; D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009154:Mutation; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D004268:DNA-Binding Proteins; C416371:PRDM16 protein, human; D014157:Transcription Factors
keywords: PRDM; PRDM16; adipose; beige fat; brown fat; transcriptional regulation