title: Aqueous synthesis of polyhedral "brick-like" iron oxide nanoparticles for hyperthermia andT2MRI contrast enhancement.
abstract: A low temperature, aqueous synthesis of polyhedral iron oxide nanoparticles (IONPs) is presented. The modification of the co-precipitation hydrolysis method with Triton X surfactants results in the formation of crystalline polyhedral particles. The particles are herein termed iron oxide "nanobricks" (IONBs) as the variety of particles made are all variations on a simple "brick-like" rhombohedral shape as evaluated by TEM. These IONBs can be easily coated with hydrophilic silane ligands, allowing them to be dispersed in aqueous media. The dispersed particles are investigated for potential applications as hyperthermia andT2MRI contrast agents. The results demonstrate that the IONBs perform better than comparable spherical IONPs in both applications, and showr2values amongst the highest for iron oxide based materials reported in the literature.
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University, Kent, OH.
authors.forename: Matthew
authors.initials: M
authors.lastname: Worden
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Bruckman
authors.affiliation: Department of Biological Sciences, Kent State University, Kent, OH.
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH ; Departments of Radiology, Materials Science and Engineering, and Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH.
authors.forename: Nicole F
authors.initials: NF
authors.lastname: Steinmetz
authors.affiliation: Department of Physics & Astronomy, University of Pennsylvania, Philadelphia, PA.
authors.forename: James M
authors.initials: JM
authors.lastname: Kikkawa
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University, Kent, OH.
authors.forename: Catherine
authors.initials: C
authors.lastname: LaSpina
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University, Kent, OH ; Liquid Crystal Institute, Chemical Physics Interdisciplinary Program, Kent State University, Kent, OH.
authors.forename: Torsten
authors.initials: T
authors.lastname: Hegmann