title: Is there a relationship between surgical case volume and mortality in congenital heart disease services? A rapid evidence review.
abstract: OBJECTIVE
  To identify and synthesise the evidence on the relationship between surgical volume and patient outcomes for adults and children with congenital heart disease.
  
  
  METHODS
  Evidence synthesis of interventional and observational studies.
  
  
  METHODS
  MEDLINE, EMBASE, CINAHL, Cochrane Library and Web of Science (2009-2014) and citation searching, reference lists and recommendations from stakeholders (2003-2014) were used to identify evidence.
  
  
  METHODS
  Quantitative observational and interventional studies with information on volume of surgical procedures and patient outcomes were included.
  
  
  RESULTS
  31 of the 34 papers identified (91.2%) included only paediatric patients. 25 (73.5%) investigated the relationship between volume and mortality, 7 (20.6%) mortality and other outcomes and 2 (5.9%) non-mortality outcomes only. 88.2% were from the US, 97% were multicentre studies and all were retrospective observational studies. 20 studies (58.8%) included all congenital heart disease conditions and 14 (41.2%) single conditions or procedures. No UK studies were identified. Most studies showed a relationship between volume and outcome but this relationship was not consistent. The relationship was stronger for single complex conditions or procedures. We found limited evidence about the impact of volume on non-mortality outcomes. A mixed picture emerged revealing a range of factors, in addition to volume, that influence outcome including condition severity, individual centre and surgeon effects and clinical advances over time.
  
  
  CONCLUSIONS
  The heterogeneity of findings from observational studies suggests that, while a relationship between volume and outcome exists, this is unlikely to be a simple, independent and directly causal relationship. The effect of volume on outcome relative to the effect of other, as yet undetermined, health system factors remains a complex and unresolved research question.
authors.affiliation: School for Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.
authors.forename: L
authors.initials: L
authors.lastname: Preston
authors.affiliation: School for Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.
authors.forename: J
authors.initials: J
authors.lastname: Turner
authors.affiliation: School for Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.
authors.forename: A
authors.initials: A
authors.lastname: Booth
authors.affiliation: School for Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.
authors.forename: C
authors.initials: C
authors.lastname: O'Keeffe
authors.affiliation: School for Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.
authors.forename: F
authors.initials: F
authors.lastname: Campbell
authors.affiliation: School for Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.
authors.forename: A
authors.initials: A
authors.lastname: Jesurasa
authors.affiliation: School for Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.
authors.forename: K
authors.initials: K
authors.lastname: Cooper
authors.affiliation: School for Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.
authors.forename: E
authors.initials: E
authors.lastname: Goyder
mesh_terms: D006330:Heart Defects, Congenital / Q000401:mortality / Q000601:surgery*; D017052:Hospital Mortality; D006801:Humans; D013503:Surgery Department, Hospital; D016526:Workload