title: FAPA mass spectrometry of designer drugs.
abstract: Application of a flowing atmospheric-pressure afterglow ion source for mass spectrometry (FAPA-MS) for the analysis of designer drugs is described. In this paper, we present application of FAPA MS for identification of exemplary psychotropic drugs: JWH-122, 4BMC, Pentedrone, 3,4-DNNC and ETH-CAT. We have utilized two approaches for introducing samples into the plasma stream; first in the form of a methanolic aerosol from the nebulizer, and the second based on a release of vapors from the electrically heated crucible by thermal desorption. The analytes were ionized by FAPA and identified in the mass analyzer. The order of release of the compounds depends on their volatility. These methods offer fast and reliable structural information, without pre-separation, and can be an alternative to the Electron Impact, GC/MS, and ESI for fast analysis of designer-, and other psychoactive drugs.
authors.affiliation: AGH University of Science and Technology, Department of Biochemistry and Neurobiology, Faculty of Materials Science and Ceramics, Al. Mickiewicza 30, 30-059 Krakow, Poland. Electronic address: smoluch@agh.edu.pl.
authors.forename: Marek
authors.initials: M
authors.lastname: Smoluch
authors.affiliation: Adam Mickiewicz University in Poznan, Faculty of Chemistry, Umultowska Str. 89b, 61-614 Poznań, Poland.
authors.forename: Blazej
authors.initials: B
authors.lastname: Gierczyk
authors.affiliation: ERTEC-Poland, Rogowska 146/5, 54-440 Wroclaw, Poland.
authors.forename: Edward
authors.initials: E
authors.lastname: Reszke
authors.affiliation: Wroclaw University of Technology, Faculty of Microsystem Electronics and Photonics, Z. Janiszewskiego 11/17, 50-372 Wroclaw, Poland.
authors.forename: Michal
authors.initials: M
authors.lastname: Babij
authors.affiliation: Wroclaw University of Technology, Faculty of Microsystem Electronics and Photonics, Z. Janiszewskiego 11/17, 50-372 Wroclaw, Poland.
authors.forename: Teodor
authors.initials: T
authors.lastname: Gotszalk
authors.affiliation: Adam Mickiewicz University in Poznan, Faculty of Chemistry, Umultowska Str. 89b, 61-614 Poznań, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Schroeder
authors.affiliation: AGH University of Science and Technology, Department of Biochemistry and Neurobiology, Faculty of Materials Science and Ceramics, Al. Mickiewicza 30, 30-059 Krakow, Poland; Centre for Polymer and Carbon Materials, Polish Academy of Sciences, Sklodowskiej-Curie 34, Zabrze, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Silberring
mesh_terms: D001274:Atmospheric Pressure; D015198:Designer Drugs / Q000032:analysis* / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods*; D058626:Plasma Gases / Q000737:chemistry; D011619:Psychotropic Drugs / Q000032:analysis* / Q000737:chemistry*
chemical_list: D015198:Designer Drugs; D058626:Plasma Gases; D011619:Psychotropic Drugs