title: Diabetes mellitus and the risk of glioma: a meta-analysis.
abstract: Some studies reported a statistically significant inverse association between diabetes mellitus (DM) and risk of gliomas. However, the result is still controversial. We thus did a meta-analysis and summarized the evidence on the incidence of gliomas that has been studied in its association with DM. Seven case-control studies and 4 cohort studies were selected in this meta-analysis (n = 5898251). DM was significantly associated with decreased risk of gliomas (OR = 0.79; 95% CI 0.67 - 0.93; P = 0.004; I2 = 59%). In the subgroup analysis of race, Caucasians of DM showed decreased risk of gliomas (OR = 0.81; 95% CI 0.69 - 0.94; P = 0.007). In the subgroup analysis of design, a statistically significant protective effect of DM on gliomas was observed in case-control studies (OR = 0.68; 95 % CI, 0.53-0.87; P = 0.002), while no such effect was observed in cohort studies (OR = 0.97; 95 % CI, 0.83-1.13; P = 0.70). In a further stratified analysis by gender, a significant association was found among males with DM (OR = 0.83; 95 % CI, 0.70-0.99; P = 0.04). No significant association was found between females with DM and gliomas (OR = 0.97; 95 % CI, 0.78-1.21; P = 0.81). In summary, this meta-analysis of current evidence suggests that DM is significantly associated with decreased gliomas risk in Caucasian and males.
authors.affiliation: Department of Geriatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, Guangzhou, China.
authors.forename: Luqian
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Geriatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, Guangzhou, China.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Department of Geriatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, Guangzhou, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
mesh_terms: D001932:Brain Neoplasms / Q000209:etiology*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D005910:Glioma / Q000209:etiology*; D006801:Humans; D008297:Male; D011379:Prognosis; D012307:Risk Factors
keywords: association; diabetes; glioma; meta-analysis