title: Wide Local Excision for Dermatofibrosarcoma Protuberans: A Single-Center Series of 90 Patients.
abstract: BACKGROUND
  Dermatofibrosarcoma protuberans (DFSP), a rare low-grade sarcoma of fibroblast origin, tends to extend in a finger-like fashion beyond macroscopic tumor margins. Therefore, incomplete removal and subsequent recurrence are common. This study aimed to determine the efficacy of wide local excision (WLE) for controlling local recurrence of DFSP.
  
  
  METHODS
  The medical records of 90 DFSP patients who received WLE at our hospital between June 1992 and January 2015 were retrospectively reviewed. WLE was conducted including a 3 cm (range, 1 to 5 cm) safety margin according to tumor size, location, and recurrence status. Clinical and tumor characteristics and surgical methods were evaluated for risk factor analysis and local recurrence-free survival.
  
  
  RESULTS
  DFSP occurred most often in patients in their 30s (30%) and on the trunk (51.1%). Five patients (5.5%) experienced local recurrence during the 43.4-month follow-up period. Recurrence was found at a mean of 10.8 months after WLE. Although no factors were significantly associated with recurrence, recurrences were more frequent in head and neck. Recurrence-free survival was 87% in 6 years and 77% in 7 years.
  
  
  CONCLUSIONS
  WLE with adequate lateral and deep margins can effectively control local recurrence rate and is a simple and effective method to treat DFSP.
authors.affiliation: Department of Plastic Surgery, College of Medicine, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea.
authors.forename: Byung Jun
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: Department of Plastic Surgery, College of Medicine, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea.
authors.forename: Hyeonwoo
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Plastic Surgery, College of Medicine, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea.
authors.forename: Ung Sik
authors.initials: US
authors.lastname: Jin
authors.affiliation: Department of Plastic Surgery, College of Medicine, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea.
authors.forename: Kyung Won
authors.initials: KW
authors.lastname: Minn
authors.affiliation: Department of Plastic Surgery, College of Medicine, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea.
authors.forename: Hak
authors.initials: H
authors.lastname: Chang
mesh_terms: D000328:Adult; D018223:Dermatofibrosarcoma / Q000401:mortality / Q000473:pathology / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D015996:Survival Rate