title: Perfluorooctane Sulfonate Plasma Half-Life Determination and Long-Term Tissue Distribution in Beef Cattle (Bos taurus).
abstract: Perfluorooctane sulfonate (PFOS) is used in consumer products as a surfactant and is found in industrial and consumer waste, which ends up in wastewater treatment plants (WWTPs). PFOS does not breakdown during WWTP processes and accumulates in the biosolids. Common practices include application of biosolids to pastures and croplands used for feed, and as a result, animals such as beef cattle are exposed to PFOS. To determine plasma and tissue depletion kinetics in cattle, 2 steers and 4 heifers were dosed with PFOS at 0.098 mg/kg body weight and 9.1 mg/kg, respectively. Plasma depletion half-lives for steers and heifers were 120 ± 4.1 and 106 ± 23.1 days, respectively. Specific tissue depletion half-lives ranged from 36 to 385 days for intraperitoneal fat, back fat, muscle, liver, bone, and kidney. These data indicate that PFOS in beef cattle has a sufficiently long depletion half-life to permit accumulation in edible tissues.
authors.affiliation: Biosciences Research Laboratory, Agricultural Research Service, USDA , 1605 Albrecht Boulevard, Fargo, North Dakota 58102, United States.
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Lupton
authors.affiliation: Office of Public Health Science, Food Safety and Inspection Service, USDA , 1400 Independence Avenue SW, Washington, DC 20250, United States.
authors.forename: Kerry L
authors.initials: KL
authors.lastname: Dearfield
authors.affiliation: Office of Public Health Science, Food Safety and Inspection Service, USDA , 2150 Centre Avenue, Building D, Suite 320, Fort Collins, Colorado 80526, United States.
authors.forename: John J
authors.initials: JJ
authors.lastname: Johnston
authors.affiliation: Department of Veterinary Technology, North Dakota State University , Hultz Hall Rm 165, Fargo, North Dakota 58102, United States.
authors.forename: Sarah
authors.initials: S
authors.lastname: Wagner
authors.affiliation: Biosciences Research Laboratory, Agricultural Research Service, USDA , 1605 Albrecht Boulevard, Fargo, North Dakota 58102, United States.
authors.forename: Janice K
authors.initials: JK
authors.lastname: Huwe
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D017738:Alkanesulfonic Acids / Q000032:analysis* / Q000097:blood*; D000818:Animals; D002417:Cattle / Q000097:blood* / Q000378:metabolism*; D005260:Female; D005466:Fluorocarbons / Q000032:analysis* / Q000097:blood*; D005506:Food Contamination / Q000032:analysis*; D059022:Food Safety; D006207:Half-Life; D008099:Liver / Q000737:chemistry; D008297:Male; D009132:Muscles / Q000737:chemistry; D000069466:Red Meat / Q000032:analysis
chemical_list: D017738:Alkanesulfonic Acids; D005466:Fluorocarbons; C076994:perfluorooctane sulfonic acid
keywords: PFOS; beef cattle; food safety; half-life; perfluorooctane sulfonate; plasma; residue