title: Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers.
abstract: The first example of mitochondrial delivery of the anticancer drug doxorubicin (Dox) is presented by lipid-functionalized DNA nanocages (LNCs). Dox localized in mitochondria induces significant cytotoxicity and cellular apoptosis in MCF-7 compared with Dox localized in lysosomes. These results suggest that LNC has the potential to be an outstanding tool in the treatment of specific organelle-related diseases such as cancers.
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.|Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China.
authors.forename: Miu Shan
authors.initials: MS
authors.lastname: Chan
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.|Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China.
authors.forename: Dick Yan
authors.initials: DY
authors.lastname: Tam
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.|Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China.
authors.forename: Ziwen
authors.initials: Z
authors.lastname: Dai
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.|Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China.
authors.forename: Ling Sum
authors.initials: LS
authors.lastname: Liu
authors.affiliation: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
authors.forename: Jonathan Weng-Thim
authors.initials: JW
authors.lastname: Ho
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
authors.forename: Man Lee
authors.initials: ML
authors.lastname: Chan
authors.affiliation: Department of Chemistry and Institute of Molecular Functional Materials, Hong Kong Baptist University, Kowloon Tong, Hong Kong, SAR, China.
authors.forename: Di
authors.initials: D
authors.lastname: Xu
authors.affiliation: Department of Chemistry and Institute of Molecular Functional Materials, Hong Kong Baptist University, Kowloon Tong, Hong Kong, SAR, China.
authors.forename: Man Shing
authors.initials: MS
authors.lastname: Wong
authors.affiliation: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
authors.forename: Chung
authors.initials: C
authors.lastname: Tin
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.|Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, China.
authors.forename: Pik Kwan
authors.initials: PK
authors.lastname: Lo
mesh_terms: D002227:Carbazoles / Q000737:chemistry; D004247:DNA / Q000378:metabolism; D004317:Doxorubicin / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry*; D004705:Endocytosis / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D008055:Lipids / Q000737:chemistry; D061986:MCF-7 Cells; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D053758:Nanoparticles / Q000737:chemistry*; D063347:Native Polyacrylamide Gel Electrophoresis; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D002227:Carbazoles; D004337:Drug Carriers; D008055:Lipids; D013501:Surface-Active Agents; D004317:Doxorubicin; D004247:DNA
keywords: DNA nanocarriers; anticancer drugs; delivery; lipophilic molecules; mitochondria