title: Waist Circumference Percentiles in Indigenous Argentinean School Children Living at High Altitudes.
abstract: BACKGROUND
  Central obesity is associated with increased risk of type 2 diabetes.
  
  
  OBJECTIVE
  The study objectives were to develop waist circumference (WC) percentiles, to determine if WC is associated with metabolic risk, and to compare our WC percentiles with those reported in the 2007-2010 National Health and Nutrition Examination Survey (NHANES).
  
  
  METHODS
  A cross-sectional study of 1232 children (606 boys ) 5-14 years was performed from 2011 to 2014 in indigenous Koya children from northwestern Argentina. Anthropometric characteristics, glucose, lipids, and insulin levels were measured. Sex-specific reference percentiles were computed using the Lambda-Mu-Sigma (LMS) method. We obtained 2007-2010 NHANES data for comparison with our results.
  
  
  RESULTS
  Compared with the NHANES 90th percentile, WC values for children in this study were lower by an average of 11.05 cm for girls and 12.66 cm for boys. The prevalence of low high-density lipoprotein cholesterol (HDL-C) was 11.8% in children with WC ≤50th percentile, 10.3% in children with WC >50th-70th percentile, 17.5% in children with WC >70th-90th percentile, and 21.3% in children with WC >90th percentile. The prevalence of high triglycerides (TG) was 19.5% in children with WC ≤50th percentile, 19.9% in children with WC >50th-70th percentile, 28.8% in children with WC >70th-90th percentile, and 39.7% in children with WC >90th percentile. Multiple logistic regression analyses showed that high TG values (>150 mg/dL) were significantly associated with WC [odds ratio (OR)] 1.05; 95% confidence interval (CI) 1.03-1.08; and low HDL-C values (<35 mg/dL) were significantly associated with WC (OR 1.04; 95% CI 1.01-1.06), adjusted for age and gender.
  
  
  CONCLUSIONS
  We present for the first time WC reference data for indigenous Koya children ages 5-14 years. There was a significant association between WC and dyslipidemia in this community. Compared with the NHANES WC percentiles, our WC values were lower. These differences possibly reflect ethnicity or the lower prevalence of obesity.
authors.affiliation: 1 Department of Pharmacology, University of Buenos Aires , Buenos Aires, Argentina .
authors.forename: Valeria
authors.initials: V
authors.lastname: Hirschler
authors.affiliation: 1 Department of Pharmacology, University of Buenos Aires , Buenos Aires, Argentina .
authors.forename: Claudia
authors.initials: C
authors.lastname: Molinari
authors.affiliation: 2 Hidalgo Laboratories , Buenos Aires, Argentina .
authors.forename: Gustavo
authors.initials: G
authors.lastname: Maccallini
authors.affiliation: 2 Hidalgo Laboratories , Buenos Aires, Argentina .
authors.forename: Mariana
authors.initials: M
authors.lastname: Hidalgo
authors.affiliation: 1 Department of Pharmacology, University of Buenos Aires , Buenos Aires, Argentina .
authors.forename: Claudio
authors.initials: C
authors.lastname: Gonzalez
mesh_terms: D000293:Adolescent; D000531:Altitude; D001118:Argentina / Q000453:epidemiology; D001827:Body Height; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D002648:Child; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006303:Health Services, Indigenous; D006801:Humans; D008297:Male; D009749:Nutrition Surveys; D056128:Obesity, Abdominal / Q000150:complications / Q000453:epidemiology* / Q000517:prevention & control*; D044382:Population Groups / Q000706:statistics & numerical data*; D011237:Predictive Value of Tests; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D055105:Waist Circumference