title: Bacterial Exopolysaccharide of Shallow Marine Vent Origin as Agent in Counteracting Immune Disorders Induced by Herpes Virus.
abstract: Herpes simplex virus type 2 (HSV-2) is responsible of the continuously increasing viral infections in humans. In a previous study we demonstrated that the exopolysaccharide produced by Bacillus licheniformis strain B3-15 (EPS-B3-15), was able to hinder the HSV-2 replication in peripheral blood mononuclear cells (PBMC) and this antiviral activity appear to be related to a significant stimulation of the Th1-cytokines. In this study we analyse the role of EPS-B3-15 on Th2 cytokine production by PBMC infected or not with HSV-2. EPS-B3-15 demonstrate the ability to induce a particular cytokine network with consequent effects on the immune cells during HSV-2 infection.
authors.affiliation: a Department of Biological and Environmental Sciences , Research Centre for Extreme Environments and Extremophiles, University of Messina , Messina , Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Spanò
authors.affiliation: b Department of Human Pathology, Unit of Clinical Microbiology , Policlinico Universitario "G. Martino," Messina , Italy.
authors.forename: Adriana
authors.initials: A
authors.lastname: Arena
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001407:Bacillus / Q000737:chemistry*; D018258:Herpesvirus 2, Human / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007154:Immune System Diseases / Q000188:drug therapy* / Q000276:immunology / Q000821:virology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology / Q000821:virology; D008826:Microbial Sensitivity Tests; D011135:Polysaccharides, Bacterial / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D011135:Polysaccharides, Bacterial
keywords: antivirals; exopolysaccharide; herpes simplex virus; immunomodulators; interleukin-4; shallow hydrothermal vents