title: SchizConnect: Virtual Data Integration in Neuroimaging.
abstract: In many scientific domains, including neuroimaging studies, there is a need to obtain increasingly larger cohorts to achieve the desired statistical power for discovery. However, the economics of imaging studies make it unlikely that any single study or consortia can achieve the desired sample sizes. What is needed is an architecture that can easily incorporate additional studies as they become available. We present such architecture based on a virtual data integration approach, where data remains at the original sources, and is retrieved and harmonized in response to user queries. This is in contrast to approaches that move the data to a central warehouse. We implemented our approach in the SchizConnect system that integrates data from three neuroimaging consortia on Schizophrenia: FBIRN's Human Imaging Database (HID), MRN's Collaborative Imaging and Neuroinformatics System (COINS), and the NUSDAST project at XNAT Central. A portal providing harmonized access to these sources is publicly deployed at schizconnect.org.
authors.affiliation: University of Southern California, Los Angeles, California, USA { ambite@isi.edu , tallis@isi.edu , konstant@isi.edu }
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Ambite
authors.affiliation: Northwestern University, Chicago, Illinois, USA { k-alpert@northwestern.edu , leiwang1@northwestern.edu }
authors.forename: Marcelo
authors.initials: M
authors.lastname: Tallis
authors.affiliation: University of California, Irvine, California, USA { dbkeator@uci.edu , sgpotkin@uci.edu }
authors.forename: Kathryn
authors.initials: K
authors.lastname: Alpert
authors.affiliation: Mind Research Network, Albuquerque, New Mexico, USA { mking@mrn.org , dlandis@mrn.org , vdcalhoun@mrn.org }
authors.forename: David B
authors.initials: DB
authors.lastname: Keator
authors.affiliation: University of New Mexico, Albuquerque, New Mexico, USA.
authors.forename: Margaret
authors.initials: M
authors.lastname: King
authors.affiliation: Georgia State University, Atlanta, Georgia, USA jturner63@gsu.edu.
authors.forename: Drew
authors.initials: D
authors.lastname: Landis
authors.forename: George
authors.initials: G
authors.lastname: Konstantinidis
authors.forename: Vince D
authors.initials: VD
authors.lastname: Calhoun
authors.forename: Steven G
authors.initials: SG
authors.lastname: Potkin
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Turner
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
keywords: Data integration; Mediation; Neuroimaging; Schema Mappings