title: Management of asymptomatic primary tumours in stage IV colorectal cancer: Review of outcomes.
abstract: OBJECTIVE
  To compare outcomes for patients presenting with stage IV colorectal cancer and an asymptomatic primary tumour, undergoing primary tumour resection (PTR) plus palliative chemotherapy vs primary chemotherapy up-front.
  
  
  METHODS
  A literature search was conducted using MEDLINE and EMBASE. The primary outcome was overall survival. Secondary outcomes included perioperative mortality, morbidity and delayed surgical intervention rates in patients undergoing PTR and subsequent complication rates in patients with an un-resected primary tumour. Tertiary outcomes included impact on systemic treatment and identification of prognostic factors relevant for survival in this cohort.
  
  
  RESULTS
  Twenty non-randomised studies met the inclusion criteria. Eleven studies included comparative overall survival data. Three studies showed an overall survival advantage for PTR, 7 studies showed no statistically significant advantage, and 1 study showed a significant worsening in survival in the surgical group. The perioperative mortality rate ranged from 0% to 8.5%, and post-operative morbidity rate from 10% to 35%, mainly minor complications that did not preclude subsequent chemotherapy. The rate of delayed primary-tumour related symptoms, most commonly obstruction, in patients with an un-resected primary tumour ranged from 3% to 46%. The strongest independent poor prognostic factor was extensive hepatic metastases, in addition to poor performance status, M1b stage and non-use of modern chemotherapy agents.
  
  
  CONCLUSIONS
  Based on the current literature, both PTR and up front chemotherapy appear appropriate initial management strategies, with a trend towards an overall survival advantage with PTR. The procedure has a low post-operative mortality, and most complications are transient and minor. The results of recruiting randomised trials are eagerly anticipated.
authors.affiliation: Kate Jessica Wilkinson, Wei Chua, Weng Ng, Aflah Roohullah, Liverpool Cancer Therapy Centre, Liverpool Hospital, Liverpool, NSW 2170, Australia.
authors.forename: Kate Jessica
authors.initials: KJ
authors.lastname: Wilkinson
authors.affiliation: Kate Jessica Wilkinson, Wei Chua, Weng Ng, Aflah Roohullah, Liverpool Cancer Therapy Centre, Liverpool Hospital, Liverpool, NSW 2170, Australia.
authors.forename: Wei
authors.initials: W
authors.lastname: Chua
authors.affiliation: Kate Jessica Wilkinson, Wei Chua, Weng Ng, Aflah Roohullah, Liverpool Cancer Therapy Centre, Liverpool Hospital, Liverpool, NSW 2170, Australia.
authors.forename: Weng
authors.initials: W
authors.lastname: Ng
authors.affiliation: Kate Jessica Wilkinson, Wei Chua, Weng Ng, Aflah Roohullah, Liverpool Cancer Therapy Centre, Liverpool Hospital, Liverpool, NSW 2170, Australia.
authors.forename: Aflah
authors.initials: A
authors.lastname: Roohullah
keywords: Asymptomatic; Chemotherapy; Colorectal cancer; Complications; Primary tumour; Resection; Unresectable metastases