title: Innovative techniques to discover novel antimalarials.
abstract: Malaria a global pandemic has engulfed nearly 0.63 million people globally. It is high time that a cure for malaria is required to stop its ever increasing menace. Our commentary discusses the advent and contribution of genetic algorithm (GA) in the drug discovery efforts towards developing cure for malaria. GAs are computational models of Darwinian evolution, ideally capture and mimic the principles of genetic variation and natural selection to evolve good solutions through multiple iterations on the space of all possible candidate solutions, called the search space, to a given optimization problem. Herein we will discuss the applications, advantages, disadvantages and future directions of GA with respect to malaria.
authors.affiliation: Department of Chemistry, School of Natural Science, Shiv Nadar University, Tehsil Dadri, Chithera, Gautam Budhnagar, 201314 UP India.
authors.forename: Santanu
authors.initials: S
authors.lastname: Hati
authors.affiliation: Department of Mathematics, School of Natural Science, Shiv Nadar University, Tehsil Dadri, Village Chithera, Gautam Budhnagar, 201314 UP India.
authors.forename: Sudeepto
authors.initials: S
authors.lastname: Bhattacharya
authors.affiliation: Department of Chemistry, School of Natural Science, Shiv Nadar University, Tehsil Dadri, Chithera, Gautam Budhnagar, 201314 UP India.
authors.forename: Subhabrata
authors.initials: S
authors.lastname: Sen
keywords: Genetic algorithm; Malaria; Metaheuristics; P. Falciparum