title: Association Between Myocardial Mechanics and Ischemic LV Remodeling.
abstract: The outcomes associated with heart failure after myocardial infarction are still poor. Both global and regional left ventricular (LV) remodeling are associated with the progression of the post-infarct patient to heart failure, but although global remodeling can be accurately measured, regional LV remodeling has been more difficult to investigate. Preliminary evidence suggests that post-MI assessment of LV mechanics using stress and strain may predict global (and possibly regional) LV remodeling. A method of predicting both global and regional LV remodeling might facilitate earlier, targeted, and more extensive clinical intervention in those most likely to benefit from novel interventions such as cell therapy.
authors.affiliation: Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
authors.forename: Nicholas
authors.initials: N
authors.lastname: D'Elia
authors.affiliation: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: D'hooge
authors.affiliation: Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. Electronic address: tom.marwick@utas.edu.au.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Marwick
mesh_terms: D057791:Cardiac Imaging Techniques / Q000379:methods; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D020342:Finite Element Analysis; D006333:Heart Failure / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000453:epidemiology; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000453:epidemiology; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000453:epidemiology; D020257:Ventricular Remodeling / Q000502:physiology
keywords: ischemic heart disease; left ventricular mechanics; left ventricular remodeling; left ventricular strain; left ventricular wall stress; left ventricular curvature