title: Use of Cannabinoids for Spasticity and Pain Management in MS.
abstract: Several randomized trials have demonstrated potential benefit of cannabis derivatives in the symptomatic treatment of multiple sclerosis (MS) patients. These provide class 1 and 2 evidence for cannabinoid product use for spasticity and pain in these patients. The precise best ratio or doses are not yet clear. The safety and potential long-term effects of these products on cognitive function in people with MS have not been evaluated. Since short-term memory and processing speed can be significantly impaired in many people with MS, the concern of potential cognitive impairment related to cannabis products needs consideration in clinical care and should be addressed in longer, prospective studies.
authors.affiliation: Department of Neurology, University of California, San Francisco, 350 Parnassus Avenue, 304 A, San Francisco, CA, 94117, USA. Hardeep.Chohan@ucsf.edu.
authors.forename: Hardeep
authors.initials: H
authors.lastname: Chohan
authors.affiliation: Department of Neurology, University of California, San Francisco, 350 Parnassus Avenue, 304 A, San Francisco, CA, 94117, USA.
authors.forename: Ariele L
authors.initials: AL
authors.lastname: Greenfield
authors.affiliation: Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
authors.forename: Vijayshree
authors.initials: V
authors.lastname: Yadav
authors.affiliation: Department of Neurology, University of California, San Francisco, 350 Parnassus Avenue, 304 A, San Francisco, CA, 94117, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Graves
keywords: Cannabidiol; Cannabinoids; Multiple sclerosis; Pain; Spasticity; Tetrahydrocannabinol