title: Impact of corticotherapy, nutrition, and sleep disorder on quality of life of patients with Duchenne muscular dystrophy.
abstract: Duchenne muscular dystrophy (DMD) is the second most common hereditary genetic disease in humans and has elevated mortality. DMD is an X-linked, life-limiting progressive muscle-wasting disease found predominantly in boys and young men. One of the main treatments for patients with DMD is corticosteroids. However, long-term use may cause major side effects such as obesity, a reduction in vitamin D, and osteoporosis. Sleep-disordered breathing is a common condition among patients with DMD, especially obstructive sleep apnea (OSA). In children, OSA is associated with obesity and a reduction of vitamin D concentration. In this article we aim to explore the interrelationship that exists between corticosteroids, obesity, OSA, and the risk of osteoporosis. Our main hypothesis is that factors such as nutrition and sleep are related to obesity and OSA, respectively. In addition, the chronic use of corticosteroids, obesity, and OSA are factors that can reduce serum levels of vitamin D, triggering osteoporosis. Thus, these factors play a key role in affecting the quality of life for patients with DMD and intervention based on these aspects may improve survival.
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Jeronimo
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Karen T
authors.initials: KT
authors.lastname: Nozoe
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Polesel
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil. Electronic address: gustavo.a.moreira@sono.org.br.
authors.forename: Gustavo A
authors.initials: GA
authors.lastname: Moreira
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Monica L
authors.initials: ML
authors.lastname: Andersen
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008297:Male; D020388:Muscular Dystrophy, Duchenne / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D009752:Nutritional Status; D009765:Obesity / Q000097:blood; D010024:Osteoporosis / Q000097:blood; D011788:Quality of Life; D012891:Sleep Apnea Syndromes / Q000097:blood; D012893:Sleep Wake Disorders / Q000097:blood*; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood
chemical_list: D000305:Adrenal Cortex Hormones; D014807:Vitamin D
keywords: Duchenne muscular dystrophy; Nutrition; Quality of life; Sleep