title: Recent advances in cancer treatment by iron chelators.
abstract: The development of new therapeutic alternatives for cancers is a major public health priority. Among the more promising approaches, the iron depletion strategy based on metal chelation in the tumoral environment has been particularly studied in recent decades. After a short description of the importance of iron for cancer cell proliferation, we will review the different iron chelators developed as potential chemotherapeutics. Finally, the recent efforts to vectorize the chelating agents specifically in the microtumoral environment will be discussed in detail.
authors.affiliation: LUNAM Université, CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Corcé
authors.affiliation: LUNAM Université, CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
authors.forename: Sébastien G
authors.initials: SG
authors.lastname: Gouin
authors.affiliation: INSERM, UMR 991, CHRU Pontchaillou, 35033 Rennes, France; Université de Rennes 1, 35043 Rennes, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Renaud
authors.affiliation: INSERM, UMR 991, CHRU Pontchaillou, 35033 Rennes, France; Université de Rennes 1, 35043 Rennes, France.
authors.forename: François
authors.initials: F
authors.lastname: Gaboriau
authors.affiliation: LUNAM Université, CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
authors.forename: David
authors.initials: D
authors.lastname: Deniaud
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D007501:Iron / Q000378:metabolism; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D007502:Iron Chelating Agents; D007501:Iron
keywords: 8-Hydroxyquinoline; Iron; Metal chelators; Polyamine; Tumor vectorisation