title: Bypassing Mechanisms of Mitochondria-Mediated Cancer Stem Cells Resistance to Chemo- and Radiotherapy.
abstract: Cancer stem cells (CSCs) are highly resistant to conventional chemo- and radiotherapeutic regimes. Therefore, the multiple drug resistance (MDR) of cancer is most likely due to the resistance of CSCs. Such resistance can be attributed to some bypassing pathways including detoxification mechanisms of reactive oxygen and nitrogen species (RO/NS) formation or enhanced autophagy. Unlike in normal cells, where RO/NS concentration is maintained at certain threshold required for signal transduction or immune response mechanisms, CSCs may develop alternative pathways to diminish RO/NS levels leading to cancer survival. In this minireview, we will focus on elaborated mechanisms developed by CSCs to attenuate high RO/NS levels. Gaining a better insight into the mechanisms of stem cell resistance to chemo- or radiotherapy may lead to new therapeutic targets thus serving for better anticancer strategies.
authors.affiliation: International Clinical Research Center, St. Anne's University Hospital, Masaryk University, Kamenice 5/A7, 625 00 Brno, Czech Republic ; Institute of Molecular Biology and Biophysics, Novosibirsk, Russia.
authors.forename: Alex
authors.initials: A
authors.lastname: Lyakhovich
authors.affiliation: Oncology and Pathology Group, Institut de Recerca Hospital Vall d'Hebron, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
authors.forename: Matilde E
authors.initials: ME
authors.lastname: Lleonart
mesh_terms: D000818:Animals; D059248:Chemoradiotherapy / Q000379:methods*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D014411:Neoplastic Stem Cells / Q000378:metabolism* / Q000473:pathology