title: Comprehensive analytical model for CW laser induced heat in turbid media.
abstract: In this work, we present a new analytical approach to model continuous wave laser induced temperature in highly homogeneous turbid media. First, the diffusion equation is used to model light transport and a comprehensive solution is derived analytically by obtaining a special Greens' function. Next, the time-dependent bio-heat equation is used to describe the induced heat increase and propagation within the medium. The bio-heat equation is solved analytically utilizing the separation of variables technique. Our theoretical model is successfully validated using numerical simulations and experimental studies with agarose phantoms and ex-vivo chicken breast samples. The encouraging results show that our method can be implemented as a simulation tool to determine important laser parameters that govern the magnitude of temperature rise within homogenous biological tissue or organs.
authors.forename: Hakan
authors.initials: H
authors.lastname: Erkol
authors.forename: Farouk
authors.initials: F
authors.lastname: Nouizi
authors.forename: Alex
authors.initials: A
authors.lastname: Luk
authors.forename: Mehmet Burcin
authors.initials: MB
authors.lastname: Unlu
authors.forename: Gultekin
authors.initials: G
authors.lastname: Gulsen
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000502:physiology* / Q000528:radiation effects; D001940:Breast / Q000502:physiology* / Q000528:radiation effects*; D002645:Chickens; D003198:Computer Simulation; D007834:Lasers; D008954:Models, Biological; D009391:Nephelometry and Turbidimetry / Q000379:methods*; D012542:Scattering, Radiation