title: [Correlations between the pathogenesis and prognosis of sudden sensorineural hearing loss and blood lipid].
abstract: OBJECTIVE
  We aimed to determine whether blood lipid parameters were related to the severity and the prognosis of idiopathic sudden sensorineural hearing loss (ISSNHL) patients.
  
  
  METHODS
  A retrospective cohort study of 258 patients with ISSNHL from December 2013 to February 2015. The distribution characteristics of lipids [total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), Non-high-density lipoprotein cholesterol (Non-HDL-C), et al] in different degree of deafness (mild, moderate, severe, and profound), hearing curve types (low frequency, high frequency, full range frequency, and completely deafness type) and prognosis of recovery (complete, partial, slight, and no recovery) were analyzed by IBM SPSS 22.0 ANOVA analysis, chi square test and multiple regression analysis.
  
  
  RESULTS
  TG level in mild hearing loss group was significantly lower than that in severe and profound hearing loss group (P = 0.017 and P = 0.007). There were no correlation between curve types and lipid indexes (P > 0.05). Non-HDL-C level was elevated in no recovery and slight recovery groups (P = 0.026 and 0.021). TC levels in partial recovery group and no recovery group were significantly higher than that in the complete recovery group (P = 0.049 and 0.042), TG was higher in slight recovery group (P = 0.014).
  
  
  CONCLUSIONS
  TG has significant correlation with the severity of hearing loss. There are negative correlations between hearing recovery and Non-HDL-C, TC and TG levels. Non-HDL-C, TC and TG might be a prognostic factor for treatment outcome in ISSNHL patients.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Provincal Hospital Affaliated to Shandong University, Jinan 250021, China.
authors.forename: Chengfang
authors.initials: C
authors.lastname: Chen
authors.forename: Mingming
authors.initials: M
authors.lastname: Wang
authors.forename: Zhaomin
authors.initials: Z
authors.lastname: Fan
authors.forename: Daogong
authors.initials: D
authors.lastname: Zhang
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Lyu
authors.forename: Hongya
authors.initials: H
authors.lastname: Wang
authors.affiliation: Email: whbotologic797@163.com.
authors.forename: Haibo
authors.initials: H
authors.lastname: Wang
mesh_terms: D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003638:Deafness; D006319:Hearing Loss, Sensorineural / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D003639:Hearing Loss, Sudden / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D008055:Lipids / Q000097:blood*; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides