title: Varioxiranols I-L, new lactones from a sponge-associated Emericella variecolor fungus.
abstract: Chemical examination of the sponge-associated fungus Emericella variecolor resulted in the isolation of four new lactones namely varioxiranols I-L(1-4)with different scaffolds, together with asteltoxin (5) and asteltoxin B (6). The structure elucidation of new compounds was accomplished by spectroscopic analysis, while the absolute configurations were determined by computed circular dichroism (ECD) and induced CD effects. Antitumor activities of these compounds were evaluated against different tumor cell lines, while the result indicated that the new compounds showed moderate cytotoxic activity against a panel of tumor cell lines.
authors.affiliation: a State Key Laboratory of Natural and Biomimetic Drugs , Peking University , Beijing 100191 , China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wu
authors.affiliation: a State Key Laboratory of Natural and Biomimetic Drugs , Peking University , Beijing 100191 , China.
authors.forename: Hai-Lin
authors.initials: HL
authors.lastname: Long
authors.affiliation: a State Key Laboratory of Natural and Biomimetic Drugs , Peking University , Beijing 100191 , China.
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.affiliation: b Institute of Pharmaceutical Biology and Biotechnology , Heinrich-Heine University , Duesseldorf 40225 , Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
authors.affiliation: a State Key Laboratory of Natural and Biomimetic Drugs , Peking University , Beijing 100191 , China.
authors.forename: Wen-Han
authors.initials: WH
authors.lastname: Lin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D032842:Emericella / Q000737:chemistry*; D006801:Humans; D007783:Lactones; D015394:Molecular Structure; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000382:microbiology*; D011753:Pyrones
chemical_list: D000970:Antineoplastic Agents; D007783:Lactones; D061065:Polyketides; D011753:Pyrones; C000607632:varioxiranol I; C030923:asteltoxin
keywords: Emericella variecolor; Fungus; cytotoxic activity; structural elucidation; varioxiranols I-L