title: Cancer stem cell-vascular endothelial cell interactions in glioblastoma.
abstract: Glioblastoma (GBM), a higher grade glial tumor, is highly aggressive, therapy resistant and often shows poor patient prognosis due to frequent recurrence. These features of GBM are attributed to presence of a significantly smaller proportion of glioma stem cells (GSCs) that are endowed with self-renewal ability, multi-potent nature and show resistance to therapy in patients. GSCs preferably take shelter close to tumor vasculature due to paracrine need of soluble factors secreted by endothelial cells (ECs) of vasculature. The physical proximity of GSCs to ECs creates a localized perivascular niche where mutual GSC-EC interactions regulate GSC stemness, migration, therapy resistance, and cellular kinetics during tumor growth. Together, perivascular niche presents a therapeutically targetable tumor structure for clinical management of GBM. Thus, understanding cellular and non-cellular components in perivascular niche is vital for designing in vitro and in vivo GBM tumor models. Here, we discuss the components and structure of tumor vascular niche and its impact on tumor progression.
authors.affiliation: National Centre for Cell Science (NCCS), SP Pune University Campus, Ganeshkhind, Pune 411007, India. Electronic address: amans@nccs.res.in.
authors.forename: Aman
authors.initials: A
authors.lastname: Sharma
authors.affiliation: National Centre for Cell Science (NCCS), SP Pune University Campus, Ganeshkhind, Pune 411007, India. Electronic address: anjali@nccs.res.in.
authors.forename: Anjali
authors.initials: A
authors.lastname: Shiras
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality; D002450:Cell Communication; D002465:Cell Movement; D018450:Disease Progression; D042783:Endothelial Cells / Q000166:cytology*; D005909:Glioblastoma / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D051379:Mice; D009364:Neoplasm Recurrence, Local; D014411:Neoplastic Stem Cells / Q000166:cytology*; D009569:Nitric Oxide / Q000378:metabolism; D010641:Phenotype; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D051880:Receptors, Notch; D016212:Transforming Growth Factor beta; D009569:Nitric Oxide
keywords: Endothelial cells; Glioma stem cell; Perivascular niche