title: A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock.
abstract: BACKGROUND
  The molecular mechanisms that determine the organism's response to a variety of doses and modalities of stress factors are not well understood.
  
  
  RESULTS
  We studied effects of ionizing radiation (144, 360 and 864 Gy), entomopathogenic fungus (10 and 100 CFU), starvation (16 h), and cold shock (+4, 0 and -4°C) on an organism's viability indicators (survival and locomotor activity) and transcriptome changes in the Drosophila melanogaster model. All stress factors but cold shock resulted in a decrease of lifespan proportional to the dose of treatment. However, stress-factors affected locomotor activity without correlation with lifespan. Our data revealed both significant similarities and differences in differential gene expression and the activity of biological processes under the influence of stress factors.
  
  
  CONCLUSIONS
  Studied doses of stress treatments deleteriously affect the organism's viability and lead to different changes of both general and specific cellular stress response mechanisms.
authors.forename: Alexey
authors.initials: A
authors.lastname: Moskalev
authors.forename: Svetlana
authors.initials: S
authors.lastname: Zhikrivetskaya
authors.forename: George
authors.initials: G
authors.lastname: Krasnov
authors.forename: Mikhail
authors.initials: M
authors.lastname: Shaposhnikov
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Proshkina
authors.forename: Dmitry
authors.initials: D
authors.lastname: Borisoglebsky
authors.forename: Anton
authors.initials: A
authors.lastname: Danilov
authors.forename: Darya
authors.initials: D
authors.lastname: Peregudova
authors.forename: Irina
authors.initials: I
authors.lastname: Sharapova
authors.forename: Eugenia
authors.initials: E
authors.lastname: Dobrovolskaya
authors.forename: Ilya
authors.initials: I
authors.lastname: Solovev
authors.forename: Nadezhda
authors.initials: N
authors.lastname: Zemskaya
authors.forename: Lyubov
authors.initials: L
authors.lastname: Shilova
authors.forename: Anastasia
authors.initials: A
authors.lastname: Snezhkina
authors.forename: Anna
authors.initials: A
authors.lastname: Kudryavtseva
mesh_terms: D000818:Animals; D058639:Cold-Shock Response; D004331:Drosophila melanogaster / Q000235:genetics / Q000382:microbiology / Q000502:physiology* / Q000528:radiation effects; D005658:Fungi / Q000502:physiology; D011839:Radiation, Ionizing; D013217:Starvation / Q000378:metabolism*; D059467:Transcriptome