title: One-pot preparation of trifluoromethylated homoallylic N-acylhydrazines or α-methylene-γ-lactams from acylhydrazines, trifluoroacetaldehyde methyl hemiacetal, allyl bromide and tin.
abstract: An efficient and convenient one-pot method for the preparation of trifluoromethylated homoallylic N-acylhydrazines or α-methylene-γ-lactams has been described. In this process, allyl bromide and metal tin are used instead of toxic stannanes, and commercially available aqueous trifluoroacetaldehyde methyl hemiacetal was used as a trifluoromethyl source.
authors.affiliation: College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, P. R. China. huyl@nwnu.edu.cn huangdf@nwnu.edu.cn.
authors.forename: Ganggang
authors.initials: G
authors.lastname: Du
authors.forename: Danfeng
authors.initials: D
authors.lastname: Huang
authors.forename: Ke-Hu
authors.initials: KH
authors.lastname: Wang
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Chen
authors.forename: Yanli
authors.initials: Y
authors.lastname: Xu
authors.forename: Junyan
authors.initials: J
authors.lastname: Ma
authors.forename: Yingpeng
authors.initials: Y
authors.lastname: Su
authors.forename: Ying
authors.initials: Y
authors.lastname: Fu
authors.forename: Yulai
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000079:Acetaldehyde / Q000031:analogs & derivatives / Q000737:chemistry*; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry*; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D014001:Tin / Q000737:chemistry*
chemical_list: D006834:Hydrazines; D006842:Hydrocarbons, Brominated; D007769:Lactams; D014001:Tin; D000079:Acetaldehyde