title: [Comparative study on packing with or without Merocel after endoscopic sinus surgery].
abstract: OBJECTIVE
  To investigate the clinical effect of nasal packing with or without Merocel after endoscopic sinus surgery (ESS) in short and long term.
  
  
  METHODS
  A total of 112 patients with chronic rhinosinusitis who received endoscopic sinus surgery were randomly divided into two groups: packed group and non-packed group. In packed group, there were 37 cases, of which 10 cases were combined with allergic rhinitis and 11 cases received correction of nasal septum at the same time. In non-packed group, there were 75 cases, of which 15 cases were combined with allergic rhinitis and 26 cases received correction of nasal septum at the same time.Visual analogue score (VAS), Nasal bleeding and sinonasal outcome Test-22 (SNOT-22) were used to evaluate the clinical effect between two groups in short and long term respectively.
  
  
  RESULTS
  The VAS of nasal obstruction, rhinodynia, dysphoria, epiphora, itching, sneeze, headache and facial pain in non-packed group were significantly lower than those in packed group (P < 0.05). Within 48 hours after ESS, the amounts of nasal bleeding were 0-45 ml (median 3 ml) in packing group and 0-18 ml (median 2 ml) in non-packing group. There were significant difference between two groups (Z = -3.54, P = 0.00). The difference value of postoperative and preoperative SNOT-22 of the packed group was 38.47 ± 20.25 and the non-packed is 41.03 ± 22.73 six months after ESS (t = 0.58, P = 0.56). Each group had one case of nasal adhesion. And as for middle turbinate dislodgement, there was one case in the packed group and two cases in the unpacked group. There was no case of nasal septum hematoma in the packed group, but two cases in the un-packed group. The results showed that there was no significant difference of clinical effect between the postoperative packing and unpacking groups.
  
  
  CONCLUSIONS
  It is safe and practicable to manage chronic rhinosinusitis without nasal packing after ESS, which in short term not only decrease discomfort, but also reduce nasal bleeding. Also, there is no significant difference of clinical effect between the postoperative packing and unpacking groups in long the term.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Shi
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Boyi
authors.initials: B
authors.lastname: Shan
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xue
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Li
authors.initials: L
authors.lastname: Qiao
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China; Email: chenfq@fmmu.edu.cn.
authors.forename: Fuquan
authors.initials: F
authors.lastname: Chen
mesh_terms: D004724:Endoscopy; D004844:Epistaxis / Q000628:therapy*; D005557:Formaldehyde / Q000627:therapeutic use*; D006801:Humans; D009300:Nasal Septum / Q000601:surgery; D059747:Nasal Surgical Procedures; D010256:Paranasal Sinuses / Q000601:surgery; D011142:Polyvinyl Alcohol / Q000627:therapeutic use*; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D012220:Rhinitis / Q000601:surgery; D012852:Sinusitis / Q000601:surgery; D014945:Wound Healing
chemical_list: D005557:Formaldehyde; C027490:polyvinyl alcohol formaldehyde foam; D011142:Polyvinyl Alcohol