title: OfftargetFinder: a web tool for species-specific RNAi design.
abstract: RNA interference (RNAi) technology is being developed as a weapon for pest insect control. To maximize the specificity that such an approach affords we have developed a bioinformatic web tool that searches the ever-growing arthropod transcriptome databases so that pest-specific RNAi sequences can be identified. This will help technology developers finesse the design of RNAi sequences and suggests which non-target species should be assessed in the risk assessment process.
  
  
  
  http://rnai.specifly.org
  
  
  
  crobin@unimelb.edu.au.
authors.affiliation: The Bio21 Institute School of Biosciences, The University of Melbourne, Melbourne 3010, Australia.
authors.forename: R T
authors.initials: RT
authors.lastname: Good
authors.affiliation: CSIRO National Facilities and Collections, Canberra, ACT 2601, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Varghese
authors.affiliation: School of Biosciences, The University of Melbourne, Melbourne 3010, Australia.
authors.forename: J F
authors.initials: JF
authors.lastname: Golz
authors.affiliation: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Melbourne 3010, Australia.
authors.forename: D A
authors.initials: DA
authors.lastname: Russell
authors.affiliation: CSIRO Land and Water Flagship, Canberra, ACT 2601, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Papanicolaou
authors.affiliation: CSIRO Land and Water Flagship, Canberra, ACT 2601, Australia.
authors.forename: O
authors.initials: O
authors.lastname: Edwards
authors.affiliation: The Bio21 Institute School of Biosciences, The University of Melbourne, Melbourne 3010, Australia.
authors.forename: C
authors.initials: C
authors.lastname: Robin
mesh_terms: D000818:Animals; D019295:Computational Biology; D030541:Databases, Genetic; D007313:Insecta; D020407:Internet; D034622:RNA Interference; D018570:Risk Assessment; D013045:Species Specificity; D059467:Transcriptome