title: Adiposity trajectory and its associations with plasma adipokine levels in children and adolescents-A prospective cohort study.
abstract: OBJECTIVE
  This study aimed to examine the associations of longitudinal adiposity measures with two adipokines, leptin and adiponectin, and their ratio in children and adolescents.
  
  
  METHODS
  A total of 953 children and adolescents participated in a 6-year longitudinal study. Body mass index (BMI), percentage body fat (%BF), and fat mass index (FMI) were used to assess adiposity status.
  
  
  RESULTS
  After adjusting for possible confounders, our regression models revealed that BMI, %BF, and FMI, in both the baseline and follow-up surveys were independently associated with a higher level of leptin and the leptin/adiponectin ratio at the follow-up survey, whereas the significant association with adiponectin only partly existed in adiposity measures at the follow-up visit. Moreover, the longitudinal change in adiposity measures was found to be a significant predictor for follow-up plasma adipokine levels. Compared with the low→low group, the medium→medium group, up-trend group, and high→high group all showed a significantly increased level of leptin and leptin/adiponectin ratio. The up-trend group and high→high group also had significantly decreased adiponectin levels.
  
  
  CONCLUSIONS
  These findings highlight the importance of adiposity surveillance and the utility of adipokines as biomarkers for adverse metabolic consequences of childhood adiposity.
authors.affiliation: MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.|School of Public Health, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Shenghui
authors.initials: S
authors.lastname: Li
authors.affiliation: Mary Ann & J. Milburn Smith Child Health Research Program, Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Memorial Hospital of Chicago and Stanley Manne Children's Research Institute, Chicago, Illinois, USA.
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.affiliation: Mary Ann & J. Milburn Smith Child Health Research Program, Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Memorial Hospital of Chicago and Stanley Manne Children's Research Institute, Chicago, Illinois, USA.
authors.forename: Lester
authors.initials: L
authors.lastname: Arguelles
authors.affiliation: Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
authors.forename: Guoying
authors.initials: G
authors.lastname: Wang
authors.affiliation: MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.|School of Public Health, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.|School of Public Health, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Shen
authors.affiliation: Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Wang
mesh_terms: D054392:Adipokines / Q000097:blood*; D050154:Adiposity; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D009765:Obesity / Q000097:blood* / Q000453:epidemiology; D011446:Prospective Studies; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
chemical_list: D054392:Adipokines; D015415:Biomarkers; D020738:Leptin