title: A high-order local time stepping finite volume solver for one-dimensional blood flow simulations: application to the ADAN model.
abstract: In recent years, the complexity of vessel networks for one-dimensional blood flow models has significantly increased, because of enhanced anatomical detail or automatic peripheral vasculature generation, for example. This fact, along with the application of these models in uncertainty quantification and parameter estimation poses the need for extremely efficient numerical solvers. The aim of this work is to present a finite volume solver for one-dimensional blood flow simulations in networks of elastic and viscoelastic vessels, featuring high-order space-time accuracy and local time stepping (LTS). The solver is built on (i) a high-order finite volume type numerical scheme, (ii) a high-order treatment of the numerical solution at internal vertexes of the network, often called junctions, and (iii) an accurate LTS strategy. The accuracy of the proposed methodology is verified by empirical convergence tests. Then, the resulting LTS scheme is applied to arterial networks of increasing complexity and spatial scale heterogeneity, with a number of one-dimensional segments ranging from a few tens up to several thousands and vessel lengths ranging from less than a millimeter up to tens of centimeters, in order to evaluate its computational cost efficiency. The proposed methodology can be extended to any other hyperbolic system for which network applications are relevant. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: National Laboratory for Scientific Computing, LNCC/MCTI. Av. Getúlio Vargas 333, 25651-075, Petrópolis, RJ, Brazil. lmuller@lncc.br.|Institute of Science and Technology in Medicine Assisted by Scientific Computing, INCT-MACC, Petrópolis, Brazil. lmuller@lncc.br.
authors.forename: Lucas O
authors.initials: LO
authors.lastname: Müller
authors.affiliation: National Laboratory for Scientific Computing, LNCC/MCTI. Av. Getúlio Vargas 333, 25651-075, Petrópolis, RJ, Brazil.|Institute of Science and Technology in Medicine Assisted by Scientific Computing, INCT-MACC, Petrópolis, Brazil.
authors.forename: Pablo J
authors.initials: PJ
authors.lastname: Blanco
authors.affiliation: Federal Rural University of Pernambuco, UFRPE, Av. Bom Pastor, s/n, Boa Vista, Garanhuns-PE, 55292-270, Brazil.|Institute of Science and Technology in Medicine Assisted by Scientific Computing, INCT-MACC, Petrópolis, Brazil.
authors.forename: Sansuke M
authors.initials: SM
authors.lastname: Watanabe
authors.affiliation: National Laboratory for Scientific Computing, LNCC/MCTI. Av. Getúlio Vargas 333, 25651-075, Petrópolis, RJ, Brazil.|Institute of Science and Technology in Medicine Assisted by Scientific Computing, INCT-MACC, Petrópolis, Brazil.
authors.forename: Raúl A
authors.initials: RA
authors.lastname: Feijóo
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular
keywords: blood flow; explicit schemes; finite volume schemes; high-order schemes; local time stepping