title: Impact of chemotherapy-induced nausea and vomiting on health-related quality of life and resource utilization: A systematic review.
abstract: BACKGROUND
  Chemotherapy-induced nausea and vomiting (CINV) is a particularly distressing event for oncology patients. This review aims at analyzing the impact of CINV on Health-Related Quality of Life (QoL) and on the use of healthcare resources.
  
  
  METHODS
  A systematic search was conducted according to the PRISMA statement on MEDLINE, EMBASE and NHS EED.
  
  
  RESULTS
  Sixty-seven studies were included in the final selection. Despite the availability of numerous treatment options, CINV was found to have a strong impact on HRQoL of patients. Direct costs are particularly affected, but this result could be due to scarcity of studies assessing indirect costs.
  
  
  CONCLUSIONS
  Evidence supports the notion that CINV continues to have a negative impact on HRQoL of patients, even for those receiving moderately emetic chemotherapy. Further studies need also to collect data on the cost of CINV, particularly indirect costs, to ensure that decisions on use of healthcare resources are better supported.
authors.affiliation: Centre for Research on Health and Social Care Management (CERGAS), Milan, Italy. Electronic address: silvia.sommariva@unibocconi.it.
authors.forename: Silvia
authors.initials: S
authors.lastname: Sommariva
authors.affiliation: Department of Medical Statistics, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Pongiglione
authors.affiliation: Centre for Research on Health and Social Care Management (CERGAS), Milan, Italy; Department of Policy Analysis and Public Management, University Bocconi, Milan, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Tarricone
mesh_terms: D000932:Antiemetics / Q000008:administration & dosage / Q000191:economics; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D017048:Health Care Costs / Q000706:statistics & numerical data; D006295:Health Resources / Q000191:economics / Q000706:statistics & numerical data*; D006801:Humans; D009325:Nausea / Q000139:chemically induced* / Q000191:economics / Q000453:epidemiology / Q000628:therapy; D009369:Neoplasms / Q000191:economics / Q000453:epidemiology / Q000628:therapy*; D011788:Quality of Life; D014839:Vomiting / Q000139:chemically induced* / Q000191:economics / Q000453:epidemiology / Q000628:therapy
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents
keywords: CINV; Direct cost; Emesis; HRQoL; Indirect cost