title: Multi-objective optimization of a continuous bio-dissimilation process of glycerol to 1, 3-propanediol.
abstract: This paper deals with multi-objective optimization of continuous bio-dissimilation process of glycerol to 1, 3-propanediol. In order to maximize the production rate of 1, 3-propanediol, maximize the conversion rate of glycerol to 1, 3-propanediol, maximize the conversion rate of glycerol, and minimize the concentration of by-product ethanol, we first propose six new multi-objective optimization models that can simultaneously optimize any two of the four objectives above. Then these multi-objective optimization problems are solved by using the weighted-sum and normal-boundary intersection methods respectively. Both the Pareto filter algorithm and removal criteria are used to remove those non-Pareto optimal points obtained by the normal-boundary intersection method. The results show that the normal-boundary intersection method can successfully obtain the approximate Pareto optimal sets of all the proposed multi-objective optimization problems, while the weighted-sum approach cannot achieve the overall Pareto optimal solutions of some multi-objective problems.
authors.affiliation: Department of Mathematics, Bohai University, Jinzhou 121013, China. Electronic address: gxxu@bhu.edu.cn.
authors.forename: Gongxian
authors.initials: G
authors.lastname: Xu
authors.affiliation: Department of Mathematics, Bohai University, Jinzhou 121013, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Mathematics, Bohai University, Jinzhou 121013, China.
authors.forename: Qunwang
authors.initials: Q
authors.lastname: Gao
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D005990:Glycerol / Q000737:chemistry*; D008954:Models, Biological; D011409:Propylene Glycols / Q000737:chemistry*
chemical_list: D011409:Propylene Glycols; C041787:1,3-propanediol; D005990:Glycerol
keywords: Bio-dissimilation process; Continuous bioprocess; Multi-objective optimization; Normal-boundary intersection method; Weighted-sum method