title: Influence of Two Various Durations of Resistance Exercise on Oxidative Stress in the Male Rat's Hearts.
abstract: BACKGROUND
  The previous studies have suggested that alteration in oxidative stress and antioxidant defense depends on various factors, such as mode, intensity, frequency and duration of exercise. In this study, we compared the effects of two various durations of resistance exercise (1 month and 4 month) on oxidative stress and antioxidant status in cardiac tissue.
  
  
  METHODS
  Thirty Wistar male rats divided into 3 groups: control (sedentary), exercise-1 (regular exercise for 1 month) and exercise-2 group (regular exercise for 4 months). After the final to the experiment, the rats were anesthetized, and then blood and heart samples were obtained and used to determine glutathione peroxidase (GPX), superoxide dismutase (SOD), malondialdehyde (MDA) and biochemical estimation.
  
  
  RESULTS
  MDA levels between control and exercise-2 groups showed no significant difference, hence, MDA level in exercise-1 group was higher compared to control group (P < .01). The heart GPX activity increased significantly in exercise-2 group regarding other groups (P < .01). The SOD activities of groups were similar. Creatine kinase (CK) and lactate dehydrogenase (LDH) concentrations increased in the exercise-1 compared to the other groups (P < .01).
  
  
  CONCLUSIONS
  Our results indicate that in heart, the adaptation and alteration in oxidative stress and cell injury level depend on duration of exercise.
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Rafigheh
authors.initials: R
authors.lastname: Ghiasi
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Mohammadi
authors.affiliation: Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Ashrafi Helan
authors.affiliation: Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
authors.forename: Seied Raziallah
authors.initials: SR
authors.lastname: Jafari Jozani
authors.affiliation: Student of Pharmacy, Pharmacy School, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Shima
authors.initials: S
authors.lastname: Mohammadi
authors.affiliation: Faculty of Management, Zabol University of Medical Sciences, Zabol, Iran.
authors.forename: Akbar
authors.initials: A
authors.lastname: Ghiasi
authors.affiliation: Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Naderi
keywords: Duration of Exercise; Oxidative Stress; Rat; Resistance Exercise