title: Mesoporous Europium-Doped Titania Nanoparticles (Eu-MTNs) for Luminescence-Based Intracellular Bio-Imaging.
abstract: Monodisperse and mesoporous europium (Eu)-doped titania nanoparticles (denoted as Eu-MTNs) were prepared by a co-synthesis method with the presence of a cationic surfactant (i.e., CTAB). A maximum loading amount of 8 mol% of Eu could be successfully incorporated into the framework of MTNs. The synthesized Eu-MTNs samples were characterized with X-ray diffraction (XRD) and scanning electron microscopy (SEM), with their luminescent property examined by photoluminescence (PL). Under ultraviolet irradiation, the Eu-MTNs samples exhibit several characteristic luminescence corresponding to 5D0-7F(j) for Eu+3 ions, which can be attributed to the energy transfer from titania nanocrystallite to Eu3+ ions dispersed in amorphous mesoporous titania region. The potential intracellular bio-imaging application of the synthesized Eu-MTN nanoparticles was demonstrated with a breast cancer cell line (i.e., BT-20). High biocompatibility and strong luminescence of the Eu-MTNs show great potential in biomedical applications.
authors.forename: Kuan-Chou
authors.initials: KC
authors.lastname: Chen
authors.forename: Saikat
authors.initials: S
authors.lastname: Dutta
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yamauchi
authors.forename: Saad M
authors.initials: SM
authors.lastname: Alshehri
authors.forename: Mai Thanh
authors.initials: MT
authors.lastname: Nguyen
authors.forename: Tetsu
authors.initials: T
authors.lastname: Yonezawa
authors.forename: Kun-Hung
authors.initials: KH
authors.lastname: Shen
authors.forename: Kevin C W
authors.initials: KC
authors.lastname: Wu
mesh_terms: D005063:Europium / Q000737:chemistry*; D049449:Luminescence; D008163:Luminescent Measurements / Q000379:methods; D008855:Microscopy, Electron, Scanning; D057054:Molecular Imaging / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D005063:Europium; D014025:Titanium