title: A Multimodal, SU-8 - Platinum - Polyimide Microelectrode Array for Chronic In Vivo Neurophysiology.
abstract: Utilization of polymers as insulator and bulk materials of microelectrode arrays (MEAs) makes the realization of flexible, biocompatible sensors possible, which are suitable for various neurophysiological experiments such as in vivo detection of local field potential changes on the surface of the neocortex or unit activities within the brain tissue. In this paper the microfabrication of a novel, all-flexible, polymer-based MEA is presented. The device consists of a three dimensional sensor configuration with an implantable depth electrode array and brain surface electrodes, allowing the recording of electrocorticographic (ECoG) signals with laminar ones, simultaneously. In vivo recordings were performed in anesthetized rat brain to test the functionality of the device under both acute and chronic conditions. The ECoG electrodes recorded slow-wave thalamocortical oscillations, while the implanted component provided high quality depth recordings. The implants remained viable for detecting action potentials of individual neurons for at least 15 weeks.
authors.affiliation: Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, building Q2, H-1117, Budapest, Hungary.|Department of Microtechnology, Institute for Technical Physics and Materials Science, Centre for Energy Research, Hungarian Academy of Sciences, Konkoly Thege M. út. 29-33, H-1121, Budapest, Hungary.|School of Ph.D. Studies, Semmelweis University, Ü llői út 26, H - 1085, Budapest, Hungary.
authors.forename: Gergely
authors.initials: G
authors.lastname: Márton
authors.affiliation: Department of Electron Devices, Budapest University of Technology and Economics, Magyar tudósok körútja 2, building Q, H-1117, Budapest, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Orbán
authors.affiliation: Department of Microtechnology, Institute for Technical Physics and Materials Science, Centre for Energy Research, Hungarian Academy of Sciences, Konkoly Thege M. út. 29-33, H-1121, Budapest, Hungary.|Department of Electron Devices, Budapest University of Technology and Economics, Magyar tudósok körútja 2, building Q, H-1117, Budapest, Hungary.
authors.forename: Marcell
authors.initials: M
authors.lastname: Kiss
authors.affiliation: Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, building Q2, H-1117, Budapest, Hungary.|Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter utca 50/a, H-1083, Budapest, Hungary.
authors.forename: Richárd
authors.initials: R
authors.lastname: Fiáth
authors.affiliation: Department of Microtechnology, Institute for Technical Physics and Materials Science, Centre for Energy Research, Hungarian Academy of Sciences, Konkoly Thege M. út. 29-33, H-1121, Budapest, Hungary.
authors.forename: Anita
authors.initials: A
authors.lastname: Pongrácz
authors.affiliation: Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, building Q2, H-1117, Budapest, Hungary.|Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter utca 50/a, H-1083, Budapest, Hungary.
authors.forename: István
authors.initials: I
authors.lastname: Ulbert
mesh_terms: D000200:Action Potentials; D000818:Animals; D000069280:Electrocorticography / Q000295:instrumentation*; D004567:Electrodes, Implanted; D008839:Microelectrodes; D010984:Platinum; D017208:Rats, Wistar
chemical_list: D010984:Platinum