title: Determination of malignant potential of cervical intraepithelial neoplasia.
abstract: Basic diagnostic procedures in cervical cancer screening are able to set the diagnosis but they do not provide any information about the biological nature and behavior of lesions. The causal link of HPV infection and cervical cancer and discoveries of complex interactions between host and HPV genome opened new possibilities in molecular diagnostics. HPV DNA analysis, determination of viral load, detection of E6 and E7 mRNA transcripts, identifying of methylation profiles, genomic changes, miRNAs, and telomerase activity should be the right choice for exact diagnostics and prediction of behavior of premalignant lesions of the cervix. These findings set a completely new light not only in diagnostic but also in management and treatment of cervical dysplasia and cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine in Martin, Comenius University, Bratislava, Slovak Republic. kudela.erik@gmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Kudela
authors.affiliation: Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University , Bratislava, Slovak Republic.
authors.forename: V
authors.initials: V
authors.lastname: Holubekova
authors.affiliation: Institute of Pathological Anatomy, Jessenius Faculty of Medicine in Martin, Comenius University, Bratislava, Slovak Republic.
authors.forename: A
authors.initials: A
authors.lastname: Farkasova
authors.affiliation: Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine in Martin, Comenius University, Bratislava, Slovak Republic.
authors.forename: J
authors.initials: J
authors.lastname: Danko
mesh_terms: D018450:Disease Progression; D005260:Female; D006801:Humans; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000821:virology
keywords: Cervical cancer; Cervical intraepithelial neoplasia; HPV