title: Three new monoterpenoid indole alkaloids from Vinca major.
abstract: Three new monoterpenoid indole alkaloids, 19-hydroxyl-10-methoxy-19, 20-dihydrovinorine (1), 19-O-acetyl-10-methoxy-19, 20-dihydrovinorine (2), and 19, 21α-dihydroxyl-10-methoxy-19, 20-dihydrovinorine (3), along with five known analogues (4-8), were isolated from the whole plants of Vinca major. The new structures were elucidated by extensive NMR and MS analysis and comparison with known compounds. In addition, compounds 1-3 were evaluated for their cytotoxicities against five human cancer cell lines.
authors.affiliation: a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming 650500 , China.|b State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Science , Kunming 650204 , China.
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Zhang
authors.affiliation: b State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Science , Kunming 650204 , China.
authors.forename: Ru-Nan
authors.initials: RN
authors.lastname: Du
authors.affiliation: b State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Science , Kunming 650204 , China.
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.affiliation: b State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Science , Kunming 650204 , China.
authors.forename: Xing-De
authors.initials: XD
authors.lastname: Wu
authors.affiliation: b State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Science , Kunming 650204 , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming 650500 , China.
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
authors.affiliation: b State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Science , Kunming 650204 , China.
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D046948:Secologanin Tryptamine Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031053:Vinca / Q000737:chemistry*
chemical_list: C000609963:19,21alpha-dihydroxyl-10-methoxy-19,20-dihydrovinorine; C000609962:19-O-acetyl-10-methoxy-19, 20-dihydrovinorine; C000609961:19-hydroxyl-10-methoxy-19, 20-dihydrovinorine; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D046948:Secologanin Tryptamine Alkaloids
keywords: Apocynaceae; Vinca major; cytotoxicity; monoterpenoid indole alkaloid