title: Characterization of brown adipose tissue ¹⁸F-FDG uptake in PET/CT imaging and its influencing factors in the Chinese population.
abstract: (18)F-FDG PET/CT has been widely applied for tumor imaging. However, it is reported that many normal tissues, e.g., brown adipose tissue, can also uptake (18)F-FDG. The purpose of this study was to determine the imaging characteristics of (18)F-FDG uptake in brown adipose tissue (BAT) in PET/CT. A total of 2,944 patients who underwent PET/CT from September 2011 to March 2013 were analyzed retrospectively. Imaging features of (18)F-FDG uptake in BAT were analyzed. Univariate analysis and logistic regression analysis were performed to evaluate the effect of age, gender, cancer status, body mass index (BMI), average daily maximum temperature of imaging month and fasting plasma glucose (Glu) on the positive rate of (18)F-FDG uptake in BAT. The results showed that 1.9% (57/2944) patients had (18)F-FDG uptake in BAT. (18)F-FDG, manifested as flaky, nodular and beaded shape, was symmetrically distributed in the adipose tissues of cervical and supraclavicular, mediastinal, paravertebral, and perirenal areas. Uptake of (18)F-FDG within cervical/supraclavicular area was most common (89.5%, 51/57) with an SUVmax ranging from 2.8 to 31.4. Univariate analysis showed that gender and cancer status were not significantly correlated with the BAT (18)F-FDG uptake rate. In contrast, age, BMI, Glu and average daily maximum temperature in the imaging month were significantly correlated with the BAT (18)F-FDG uptake rate (P<0.05). Further logistic regression analysis showed that only age, BMI and average daily maximum temperature were significant (OR<1, P<0.05). Based on the value of OR, the most significant factor that affects BAT (18)F-FDG uptake rate was age, followed by the average daily maximum temperature and BMI. We concluded that Chinese adult has low positive rate of (18)F-FDG uptake in BAT. Cervical/Supraclavicular is the most common area with BAT (18)F-FDG uptake. Age, average daily maximum temperature and BMI are independent factors affecting (18)F-FDG uptake.
authors.affiliation: Department of Nuclear Medicine, the third affiliated hospital of Soochow University, Changzhou 213003, China.
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Shao
authors.affiliation: Department of Nuclear Medicine, the third affiliated hospital of Soochow University, Changzhou 213003, China.
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Shao
authors.affiliation: Department of Nuclear Medicine, the third affiliated hospital of Soochow University, Changzhou 213003, China.
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Nuclear Medicine, the third affiliated hospital of Soochow University, Changzhou 213003, China. Electronic address: yuetao-w@163.com.
authors.forename: Yuetao
authors.initials: Y
authors.lastname: Wang
mesh_terms: D002001:Adipose Tissue, Brown / Q000000981:diagnostic imaging / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001692:Biological Transport; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002648:Child; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D015999:Multivariate Analysis; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D012727:Sex Characteristics; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18
keywords: Brown adipose tissue; Deoxyglucose; Emission-computed; Tomography; X-ray computed