title: Evolving epidemiology of carbapenemase-producing Enterobacteriaceae in Portugal: 2012 retrospective cohort at a tertiary hospital in Lisbon.
abstract: Despite great efforts to enhance European epidemiological surveillance on carbapenemase-producing Enterobacteriaceae (CPE), information from several countries remains scarce. To address CPE epidemiology in Portugal, we have undertaken a retrospective cohort study of adults with CPE cultures identified in the microbiology laboratory of a tertiary hospital, in 2012. Sixty patients from 25 wards or intensive care units were identified. This is, to the best of our knowledge, the first report of clinical data on CPE in Portugal. It shows a hospital-wide CPE dissemination and alerts us to an evolving epidemiological situation not previously described.
authors.affiliation: Department of Infectious Diseases, Centro Hospitalar de Lisboa Norte, Lisbon, Portugal. Electronic address: danicpires@gmail.com.
authors.forename: D
authors.initials: D
authors.lastname: Pires
authors.affiliation: Department of Infectious Diseases, Centro Hospitalar de Lisboa Norte, Lisbon, Portugal; Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Zagalo
authors.affiliation: Department of Infectious Diseases, Centro Hospitalar de Lisboa Norte, Lisbon, Portugal; Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
authors.forename: C
authors.initials: C
authors.lastname: Santos
authors.affiliation: Department of Infectious Diseases, Centro Hospitalar de Lisboa Norte, Lisbon, Portugal; Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
authors.forename: F
authors.initials: F
authors.lastname: Cota de Medeiros
authors.affiliation: Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Duarte
authors.affiliation: Laboratory of Microbiology, Department of Clinical Pathology, Centro Hospitalar de Lisboa Norte, Lisbon, Portugal.
authors.forename: L
authors.initials: L
authors.lastname: Lito
authors.affiliation: Faculty of Medicine, University of Lisbon, Lisbon, Portugal; Laboratory of Microbiology, Department of Clinical Pathology, Centro Hospitalar de Lisboa Norte, Lisbon, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Melo Cristino
authors.affiliation: Department of Infectious Diseases, Centro Hospitalar de Lisboa Norte, Lisbon, Portugal; Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
authors.forename: L
authors.initials: L
authors.lastname: Caldeira
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001426:Bacterial Proteins / Q000378:metabolism*; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011174:Portugal / Q000453:epidemiology; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase
keywords: Carbapenemase-producing Enterobacteriaceae; Epidemiology; Hospital-acquired infection; Portugal