title: Serotnin as a possible biomarker in obstructive sleep apnea.
abstract: Obstructive sleep apnea (OSA) is a highly prevalent disease which carries substantial public health burden. Polysomnography is the standard procedure used to diagnose OSA. However cost, accessibility, technical requirements, and skilled interpretation needs constrain its widespread use and have a role in the under-diagnosis of sleep disordered breathing. There is a clinical need to develop expedient and widely accessible tools to detect this disorder., Several biochemical markers have recently been proposed as diagnostic tools in OSA. Numerous neurochemicals directly influence the activity of upper airway dilator motor neurons, which subsequently influence respiration during sleep. Serotonin (5-HT) is one such neurochemical that has a key role in ventilatory stimulation. Herein, we review the current evidence demonstrating relationships between multiple biomarkers and sleep disordered breathing and focus on relationships between OSA and 5-HT. We discuss the possibility of biomarker-driven detection technology in the future as a means of diagnosing and monitoring OSA. Finally, we explore the specific role 5-HT may have in the future in both the diagnosis and treatment of OSA.
authors.affiliation: Center for Sleep Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Lipford
authors.affiliation: Center for Sleep Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Kannan
authors.initials: K
authors.lastname: Ramar
authors.affiliation: International Sleep Science & Technology Association, Berlin, Germany; Department of Life Science, Fu Jen Catholic University, New Taipei City, Taiwan.
authors.forename: Yao-Jen
authors.initials: YJ
authors.lastname: Liang
authors.affiliation: International Sleep Science & Technology Association, Berlin, Germany; Graduate Institute of Bioelectronics and Bioinformatics, National Taiwan University, Taiwan; Graduate Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
authors.forename: Chii-Wann
authors.initials: CW
authors.lastname: Lin
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Yun-Ting
authors.initials: YT
authors.lastname: Chao
authors.affiliation: Graduate Institute of Bioelectronics and Bioinformatics, National Taiwan University, Taiwan.
authors.forename: Jen
authors.initials: J
authors.lastname: An
authors.affiliation: Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan.
authors.forename: Chih-Hsien
authors.initials: CH
authors.lastname: Chiu
authors.affiliation: School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
authors.forename: Yi-Ju
authors.initials: YJ
authors.lastname: Tsai
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Chih-Hung
authors.initials: CH
authors.lastname: Shu
authors.affiliation: Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Fei-Peng
authors.initials: FP
authors.lastname: Lee
authors.affiliation: International Sleep Science & Technology Association, Berlin, Germany; Department of Otolaryngology Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei, Taiwan; Sleep Technology Special Interest Group, INSIGHT Center, National Taiwan University, Taipei, Taiwan; Center of Sleep Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address: rayleighchiang@ntu.edu.tw.
authors.forename: Rayleigh Ping-Ying
authors.initials: RP
authors.lastname: Chiang
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D012137:Respiratory System / Q000503:physiopathology; D012701:Serotonin / Q000378:metabolism*; D012890:Sleep; D020181:Sleep Apnea, Obstructive / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D012701:Serotonin
keywords: Alternative OSA treatments; Biomarkers; Obstructive sleep apnea (OSA); Polysomnography; Serotonin (5-HT); Sleep-disordered breathing