title: Design, synthesis and bioactivity evaluation of Galf mimics as antitubercular agents.
abstract: A series of novel Galf mimics has been synthesized and characterized by IR, (1)H NMR, (13)C NMR, mass spectral and element analysis. All the newly prepared compounds were screened for their antitubercular activities. Bioactivity assays manifested that most of Galf mimics exhibited good antitubercular activities. Especially compound 4d and 4e displayed remarkable antitubercular efficacies, which were comparable to ethambutol.
authors.affiliation: School of Pharmacy, North China University of Science and Technology, Tangshan 063000, China. Electronic address: chunyanliu@ncst.edu.cn.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Liu
authors.affiliation: School of Public Health, North China University of Science and Technology, Tangshan 063000, China.
authors.forename: Linyu
authors.initials: L
authors.lastname: Hou
authors.affiliation: Affiliated Hospital, North China University of Science and Technology, Tangshan 063000, China.
authors.forename: Aiguo
authors.initials: A
authors.lastname: Meng
authors.affiliation: School of Pharmacy, North China University of Science and Technology, Tangshan 063000, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Han
authors.affiliation: School of Pharmacy, North China University of Science and Technology, Tangshan 063000, China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
authors.forename: Shende
authors.initials: S
authors.lastname: Jiang
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002473:Cell Wall / Q000187:drug effects* / Q000378:metabolism; D015195:Drug Design; D004977:Ethambutol / Q000494:pharmacology; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D005690:Galactose / Q000031:analogs & derivatives / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D006001:Glycoconjugates / Q000037:antagonists & inhibitors* / Q000737:chemistry; D050113:Imino Furanoses / Q000737:chemistry; D019751:Intramolecular Transferases / Q000235:genetics / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D018716:Molecular Mimicry; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D014166:Transferases / Q000235:genetics / Q000378:metabolism; D014530:Uridine Diphosphate / Q000031:analogs & derivatives / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D000995:Antitubercular Agents; D005656:Fungal Proteins; D006001:Glycoconjugates; D050113:Imino Furanoses; C104136:uridine diphosphate galactofuranose; D014530:Uridine Diphosphate; D004977:Ethambutol; D014166:Transferases; D019751:Intramolecular Transferases; C098051:UDP-galactopyranose mutase; D005690:Galactose
keywords: Antimycobacterial activity; Galf mimics; Mycobacterium tuberculosis; UDP-galactopyranose mutase