title: Analysis of HLA-DQB1 allele polymorphisms in Uyghur women with cervical cancer.
abstract: In Uyghur women, mortality rates from cervical cancer are amongst the highest in the nation, and genetic susceptibility probably plays a role in the pathogenesis of the disease. We investigated the correlation between polymorphisms of the HLA-DQB1 allele and cervical cancer in Xinjiang Uyghur women. Cervix tissue samples from 80 cases of cervical cancer and 80 cases of cervicitis were genotyped using polymerase chain reaction-sequence-based typing (PCR-SBT) for HLA-DQB1. Two hundred and ninety-six alleles were identified among the 160 cases. One hundred and thirty-six alleles were heterozygous and 24 were homozygous. Using frequency calculations and statistical analysis, we found that HLA-DQB1*0325 (OR: 10.60, 1.341-83.81) and HLA-DQB1*0332 (OR: 12.59, 2.909-54.526) were more frequently identified in the cervical cancer group compared with the cervicitis group (P < 0.05). However, HLA-DQB1*0317 (OR: 0.49, 0.304-0.798) and HLA-DQB1*040302 (OR: 0.40, 0.243-0.658) were present less frequently in the cervical cancer group (P < 0.05). The frequency of the HLA-DQB1 genotype in Uyghur was different from that reported previously in other areas. HLA-DQB1*0325 and HLA-DQB1*0332 probably act as cervical cancer susceptibility genes in Uyghur women from Xinjiang. In contrast, HLA-DQB1*0317 and HLA-DQB1*040302 may be protective genes.
authors.affiliation: Department of Gynecology, Xinjiang Uyghur Autonomous Region People's Hospital, Urumqi, China.|Postgraduate College of Xinjiang Medical University, Urumqi, China.
authors.forename: L
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Gynecology, Xinjiang Uyghur Autonomous Region People's Hospital, Urumqi, China.
authors.forename: S
authors.initials: S
authors.lastname: Husaiyin
authors.affiliation: Department of Gynecology, Xinjiang Uyghur Autonomous Region People's Hospital, Urumqi, China.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Gynecology, Xinjiang Uyghur Autonomous Region People's Hospital, Urumqi, China.
authors.forename: K D
authors.initials: KD
authors.lastname: Wusainahong
authors.affiliation: Department of Gynecology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: X
authors.initials: X
authors.lastname: Fu
authors.affiliation: Department of Gynecology, Xinjiang Uyghur Autonomous Region People's Hospital, Urumqi, China.
authors.forename: M
authors.initials: M
authors.lastname: Niyazi
mesh_terms: D000328:Adult; D000483:Alleles; D052685:Alphapapillomavirus / Q000145:classification / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005006:Ethnicity / Q000235:genetics*; D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059866:HLA-DQ beta-Chains / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D030361:Papillomavirus Infections / Q000150:complications / Q000821:virology; D011110:Polymorphism, Genetic; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D055815:Young Adult
chemical_list: D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen