title: [Radiosensitivity and/or radioresistance of head and neck cancers: Biological angle].
abstract: Radiation therapy is a cornerstone of head and neck cancer management. Technological improvements in recent years in radiation therapy, with intensity-modulated techniques, reinforce even more its role. However, both local and locoregional relapses are still observed. Understanding biological mechanisms of treatment resistance is a topic of major interest. From the cancer cell itself, its ability to repair and proliferate, its microenvironment and oxygenation conditions, migratory and invasive capacity, to biological parameters related to the patient, there are many mechanisms involving radiosensitivity and/or radioresistance of head and neck cancer. The present study explores the main biological mechanisms involved in radiation resistance of head and neck cancer, and describes promising therapeutic approaches.
authors.affiliation: Institut de cancérologie de la Loire-Lucien-Neuwirth, département de radiothérapie, 108, bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France; Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Guy
authors.affiliation: Institut de cancérologie de la Loire-Lucien-Neuwirth, département de radiothérapie, 108, bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Chloé
authors.initials: C
authors.lastname: Rancoule
authors.affiliation: Institut de cancérologie de la Loire-Lucien-Neuwirth, département de radiothérapie, 108, bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France; Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France.
authors.forename: Benoîte
authors.initials: B
authors.lastname: Méry
authors.affiliation: Institut de cancérologie de la Loire-Lucien-Neuwirth, département de radiothérapie, 108, bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Espenel
authors.affiliation: Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Wozny
authors.affiliation: Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Simonet
authors.affiliation: Institut de cancérologie de la Loire-Lucien-Neuwirth, département de radiothérapie, 108, bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Vallard
authors.affiliation: Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France.
authors.forename: Gersende
authors.initials: G
authors.lastname: Alphonse
authors.affiliation: Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Ardail
authors.affiliation: Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Rodriguez-Lafrasse
authors.affiliation: Institut de cancérologie de la Loire-Lucien-Neuwirth, département de radiothérapie, 108, bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France; Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France. Electronic address: nicolas.magne@icloire.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Magné
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy*; D015687:Cell Hypoxia; D002465:Cell Movement; D049109:Cell Proliferation; D004260:DNA Repair; D019583:Dose Fractionation, Radiation; D058750:Epithelial-Mesenchymal Transition; D066246:ErbB Receptors / Q000502:physiology; D006258:Head and Neck Neoplasms / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy*; D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D014411:Neoplastic Stem Cells / Q000502:physiology; D010038:Otorhinolaryngologic Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy*; D061766:Proton Therapy / Q000379:methods; D011836:Radiation Tolerance / Q000502:physiology*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D012307:Risk Factors; D059016:Tumor Microenvironment
chemical_list: D011838:Radiation-Sensitizing Agents; D066246:ErbB Receptors
keywords: Cancer ORL; Cancer stem cells; Carbon ion; Cellules souches cancéreuses; EGFR; Hadronthérapie; Head and neck neoplasms; Hypoxia; Hypoxie; Radiobiologie; Radiobiology