title: PC400 volumetric coils minimize radiation, reduce procedure time and optimize packing density during endovascular treatment in medium sized cerebral aneurysms.
abstract: OBJECTIVE
  The Penumbra Coil 400 (PC400) is designed to improve endovascular filling for intracranial aneurysms. The aim of this retrospective, single-operator study was to compare the use of the PC400 with conventional 0.010inch coils in procedure time, X-ray exposure and packing density.
  
  
  METHODS
  We collected data from 31patients with 6 to 10mm diameter aneurysms embolized using the PC400, from May 2012 to November 2013. This group was compared with a control group of 27patients treated with conventional 0.010inch coils by the same operator. In both groups, clinical events, number of coils used, duration and cost of procedure, time of fluoroscopy and packing density were studied.
  
  
  RESULTS
  No serious adverse events were found in either group. Asymptomatic prolapse of coil loop into the parent artery were noted in two patients. Number of coils used was 4.45/6.35 in PC400 and control groups, respectively. Duration of procedure was 29.8/49.2minutes respectively (P-value=0.0002), and time of fluoroscopy was 28/41minutes (P-value=0.0109). Total radiation was 6098/6876cGy.cm(2) respectively. Comparison of packing densities after the first coil showed respectively 22.7%/10.6%, and after the final imaging, 53%/28.5% (P-values<0.0001). Complete or near complete occlusion on follow-up at 3months was 100% for PC400 versus 92% in the control group. Using 0.010inch coils may result in a 56% increase in treatment cost.
  
  
  CONCLUSIONS
  PC400 coils save procedural time and time of fluoroscopy, are cost saving and allow dramatic improvement of packing density on final imaging.
authors.affiliation: Neuroradiology Department, Bordeaux University Hospital, Bordeaux, France. Electronic address: jerome.berge@chu-bordeaux.fr.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Berge
authors.affiliation: Neuroradiology Department, Bordeaux University Hospital, Bordeaux, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Gariel
authors.affiliation: Neuroradiology Department, Bordeaux University Hospital, Bordeaux, France.
authors.forename: Gauthier
authors.initials: G
authors.lastname: Marnat
authors.affiliation: Neuroradiology Department, Bordeaux University Hospital, Bordeaux, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Dousset
mesh_terms: D004621:Embolization, Therapeutic / Q000295:instrumentation*; D057510:Endovascular Procedures; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Embolization; Endovascular procedures; Intracranial aneurysm/therapy; Therapeutic/instrumentation; Therapeutic/methods; Treatment outcome