title: Associations of Different Adipose Tissue Depots with Insulin Resistance: A Systematic Review and Meta-analysis of Observational Studies.
abstract: Fat distribution is strongly associated with insulin resistance, a risk factor for type 2 diabetes and cardiovascular diseases. However, associations of different adipose tissue depots or/and obesity indices with insulin resistance have not been systematically evaluated. In this study we examined associations of different adipose tissue depots/obesity indices with insulin resistance, as measured by homeostatic model assessment of insulin resistance (HOMA-IR) in observational studies. A total of 40 studies with 56 populations and 29 adipose tissue depots/obesity indices were included in the meta-analysis. There were strong correlation between HOMA-IR and visceral fat mass (r = 0.570, 95% confidence interval(CI): 0.424~0.687), total fat mass (r = 0.492, 95%CI: 0.407~0.570), body mass index (r = 0.482, 95%CI: 0.445~0.518) and waist circumference (r = 0.466, 95%CI: 0.432~0.500), except lower extremity fat (r = 0.088, 95%CI: -0.116~0.285). Sample size, diabetic status, gender, mean of body mass index, and race contributed to heterogeneity of these associations. This study showed a positive correlation between insulin resistance and most adipose tissue depots/obesity indices, and the strongest association is for visceral fat mass.
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, China.|Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, PR China.
authors.forename: Mingzhi
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Public Health and Tropic Medicine, Tulane University, New Orleans, Louisiana, USA.
authors.forename: Tian
authors.initials: T
authors.lastname: Hu
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, China.|Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, PR China.
authors.forename: Shaoyan
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
mesh_terms: D000273:Adipose Tissue / Q000503:physiopathology*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000150:complications / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D012307:Risk Factors; D055105:Waist Circumference