title: Lower CSF Aβ is Associated with HAND in HIV-Infected Adults with a Family History of Dementia.
abstract: Both family history of dementia (FHD) and lower levels of Aβ-42 are indepentently associated with worse neurocognitive functioning in HIVinfected patients.
  
  
  
  To examine the relationships between cerebrospinal fluid (CSF) Aβ-42 and FHD with HIV-associated neurocognitive disorders (HAND).
  
  
  
  One hundred eighty-three HIV+ adults underwent neuropsychological and neuromedical assessments, and determination of CSF Aβ-42 concentration and FHD (defined as a self-reported first or second-degree relative with a dementia diagnosis). Univariate analyses and multivariable logistic regressions were used.
  
  
  
  FHD was not associated with HAND (p = 0.24); however, CSF Aβ-42 levels were lower (p = 0.03) in the HAND group, but were not associated with FHD (p = 0.89). Multivariable models showed a main effect of CSF Aβ-42 (p = 0.03) and a trend-level (p = 0.06) interaction between FHD and CSF Aβ-42, such that lower CSF Aβ-42 was associated with HAND in those with FHD (p < 0.01) compared to those without FHD (p = 0.83). An analysis in those with follow-up data showed that higher baseline CSF Aβ-42 was associated with lower risk of neurocognitive decline (p = 0.02). While we did not find an FHD X CSF Aβ-42 interaction (p = 0.83), when analyses were stratified by FHD, lower CSF Aβ-42 was associated at the trend-level with neurocognitive decline in the FHD group (p = 0.08) compared to the no FHD group (p = 0.15).
  
  
  
  FHD moderates the relationship between of CSF Aβ-42 and HAND. The findings highlight the complexities in interpreting the relationships between biomarkers of age-related neurodegeneration and HAND.
authors.forename: Pariya L
authors.initials: PL
authors.lastname: Fazeli
authors.affiliation: University of California, San Diego, 220 Dickinson St, Ste B, San Diego, CA 92103, USA. djmoore@ucsd.edu.
authors.forename: David J
authors.initials: DJ
authors.lastname: Moore
authors.forename: Donald R
authors.initials: DR
authors.lastname: Franklin
authors.forename: Anya
authors.initials: A
authors.lastname: Umlauf
authors.forename: Robert K
authors.initials: RK
authors.lastname: Heaton
authors.forename: Ann C
authors.initials: AC
authors.lastname: Collier
authors.forename: Christina M
authors.initials: CM
authors.lastname: Marra
authors.forename: David B
authors.initials: DB
authors.lastname: Clifford
authors.forename: Benjamin B
authors.initials: BB
authors.lastname: Gelman
authors.forename: Ned C
authors.initials: NC
authors.lastname: Sacktor
authors.forename: Susan
authors.initials: S
authors.lastname: Morgello
authors.forename: David M
authors.initials: DM
authors.lastname: Simpson
authors.forename: John A
authors.initials: JA
authors.lastname: McCutchan
authors.forename: Igor
authors.initials: I
authors.lastname: Grant
authors.forename: Scott L
authors.initials: SL
authors.lastname: Letendre
mesh_terms: D015526:AIDS Dementia Complex / Q000473:pathology*; D000328:Adult; D016229:Amyloid beta-Peptides / Q000032:analysis*; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D003430:Cross-Sectional Studies; D003704:Dementia / Q000473:pathology*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D016229:Amyloid beta-Peptides