title: Gestational diabetes - metabolic risks of adult women with respect to birth weight.
abstract: Metabolic disorders such as obesity, insulin resistance and other components of metabolic syndrome (MetS) are connected with birth weight. Low and high birth weight is associated with a higher risk of developing type 2 diabetes mellitus, the mechanism is not clear. In this study, we evaluated the association between birth weight and anthropometric as well as biochemical components of MetS in women with a history of gestational diabetes mellitus (GDM) in comparison with control women. In part of the GDM group, we re-evaluated metabolic changes over 5-8 years. Anthropometry, blood pressure, glucose metabolism during the 3-h oGTT, lipid profile, uric acid, thyroid hormones, and liver enzymes were assessed. From the analyzed components of MetS in adult women we proved the association of low birth weight (birth weight <25th percentile) with glucose processing, in particular among women with a history of GDM. Low birth weight GDM women revealed significantly higher postchallenge insulin secretion and lower peripheral insulin sensitivity. Re-examinations indicate this association persists long after delivery.
authors.affiliation: Department of Molecular Endocrinology, Institute of Endocrinology, Prague, Czech Republic. dvejrazkova@endo.cz.
authors.forename: D
authors.initials: D
authors.lastname: Vejrazkova
authors.forename: P
authors.initials: P
authors.lastname: Lukasova
authors.forename: M
authors.initials: M
authors.lastname: Vankova
authors.forename: O
authors.initials: O
authors.lastname: Bradnova
authors.forename: G
authors.initials: G
authors.lastname: Vacinova
authors.forename: J
authors.initials: J
authors.lastname: Vcelak
authors.forename: V
authors.initials: V
authors.lastname: Cirmanova
authors.forename: K
authors.initials: K
authors.lastname: Andelova
authors.forename: H
authors.initials: H
authors.lastname: Krejci
authors.forename: B
authors.initials: B
authors.lastname: Bendlova
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000502:physiology*; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism*; D008875:Middle Aged; D011247:Pregnancy; D012307:Risk Factors