title: Outcome of Multifetal Pregnancy Reduction in Women with a Dichorionic Triamniotic Triplet Pregnancy to a Singleton Pregnancy: A Retrospective Nationwide Cohort Study.
abstract: OBJECTIVE
  To study the pregnancy outcomes of women with a dichorionic triamniotic triplet pregnancy that was reduced to a singleton pregnancy and to review the literature.
  
  
  METHODS
  We performed a nationwide retrospective cohort study. We compared time to delivery and perinatal mortality in dichorionic triplet pregnancies reduced to singletons with ongoing dichorionic triplet pregnancies and primary singleton pregnancies. Additionally, we reviewed the literature on the subject.
  
  
  RESULTS
  We studied 46 women with a reduced dichorionic triplet pregnancy and 42 women with an ongoing dichorionic triplet pregnancy. Median gestational age at delivery was 38.7 vs. 32.8 weeks, respectively (p < 0.001). Delivery <24 weeks occurred in 9 (19.6%) women with a reduced triplet pregnancy and 4 (9.5%) with an ongoing triplet pregnancy (p = 0.19). Perinatal survival rates between the reduced group and the ongoing triplet group were not significantly different.
  
  
  CONCLUSIONS
  Multifetal pregnancy reduction in women with a dichorionic triplet pregnancy to a singleton pregnancy prolongs median gestational age at birth. No statistically significant association was found with miscarriage and perinatal survival rates.
authors.affiliation: Departments of Obstetrics and Gynecology, VU Medical Center, Amsterdam, The Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: van de Mheen
authors.forename: S M P
authors.initials: SM
authors.lastname: Everwijn
authors.forename: M C
authors.initials: MC
authors.lastname: Haak
authors.forename: G T R
authors.initials: GT
authors.lastname: Manten
authors.forename: H A
authors.initials: HA
authors.lastname: Zondervan
authors.forename: M F C M
authors.initials: MF
authors.lastname: Knapen
authors.forename: M A J
authors.initials: MA
authors.lastname: Engels
authors.forename: J J H M
authors.initials: JJ
authors.lastname: Erwich
authors.forename: A B
authors.initials: AB
authors.lastname: Coumans
authors.forename: J M G
authors.initials: JM
authors.lastname: van Vugt
authors.forename: C M
authors.initials: CM
authors.lastname: Bilardo
authors.forename: M G
authors.initials: MG
authors.lastname: van Pampus
authors.forename: C J M
authors.initials: CJ
authors.lastname: de Groot
authors.forename: B W J
authors.initials: BW
authors.lastname: Mol
authors.forename: E
authors.initials: E
authors.lastname: Pajkrt
mesh_terms: D000328:Adult; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D018607:Pregnancy Reduction, Multifetal; D059286:Pregnancy, Triplet; D012189:Retrospective Studies; D016896:Treatment Outcome