title: Recent Progress on Graphene-based Electrochemical Biosensors.
abstract: The detailed records and conclusions on the important advancements in graphene-based electrochemical biosensors have been reviewed. Due to their outstanding properties, graphene-based materials have been widely studied for the accurate electrochemical detection of many biomolecules, which is extremely vital to the development of biomedical instruments, clinical diagnosis, and disease treatment. This review discusses the graphene research for the effective immobilization of enzymes, including glucose oxidase, horseradish peroxidase, and hemoglobin, etc., and the accurate detection of biomolecules, including glucose, hydrogen peroxide, dopamine, ascorbic acid, uric acid, nicotinamide adenine dinucleotide, DNA, RNA, and carcinoembryonic antigen, etc. In most of the cases, the graphene-based biosensors exhibited remarkable performance with high sensitivities, wide linear detection ranges, low detection limits, and long-term stabilities.
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, National Jiangsu Synergistic Innovation Center for Advanced Materials (SICAM), 9 Wenyuan Road, Nanjing, 210023, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, National Jiangsu Synergistic Innovation Center for Advanced Materials (SICAM), 9 Wenyuan Road, Nanjing, 210023, P. R. China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Shen
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, National Jiangsu Synergistic Innovation Center for Advanced Materials (SICAM), 9 Wenyuan Road, Nanjing, 210023, P. R. China.
authors.forename: Huihua
authors.initials: H
authors.lastname: Li
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, National Jiangsu Synergistic Innovation Center for Advanced Materials (SICAM), 9 Wenyuan Road, Nanjing, 210023, P. R. China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, National Jiangsu Synergistic Innovation Center for Advanced Materials (SICAM), 9 Wenyuan Road, Nanjing, 210023, P. R. China.
authors.forename: Dashun
authors.initials: D
authors.lastname: Cao
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, National Jiangsu Synergistic Innovation Center for Advanced Materials (SICAM), 9 Wenyuan Road, Nanjing, 210023, P. R. China.
authors.forename: Xiaomiao
authors.initials: X
authors.lastname: Feng
authors.affiliation: The South Subtropical Crops Research Institute Chinese Academy of Tropical Agricultural Science, Zhanjiang, 524091, P. R. China.
authors.forename: Yuge
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, National Jiangsu Synergistic Innovation Center for Advanced Materials (SICAM), 9 Wenyuan Road, Nanjing, 210023, P. R. China.
authors.forename: Yanwen
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, National Jiangsu Synergistic Innovation Center for Advanced Materials (SICAM), 9 Wenyuan Road, Nanjing, 210023, P. R. China.
authors.forename: Lianhui
authors.initials: L
authors.lastname: Wang
mesh_terms: D015374:Biosensing Techniques; D055664:Electrochemical Techniques; D005949:Glucose Oxidase / Q000378:metabolism; D006108:Graphite / Q000737:chemistry*; D006801:Humans
chemical_list: D006108:Graphite; D005949:Glucose Oxidase
keywords: biosensors; electrochemical biosensors; enzymatic; graphene; nonenzymatic