title: Combined effects of chronic hyperglycaemia and oral aluminium intoxication on testicular tissue and some male reproductive parameters in Wistar rats.
abstract: Exposure to either environmental toxicants or chronic hyperglycaemia could impair male reproductive function. However, the extent to which exposure to such toxicants, in the presence of pre-existing metabolic dysfunction, could affect male reproduction is unclear. Streptozotocin-induced diabetic Wistar rats (12 weeks old) were exposed to oral aluminium chloride at 250 ppm for 30 days; followed by evaluation of caudal epididymal sperm count and motility, assay for serum follicle stimulating hormone (FSH), testosterone (T) and oestradiol; and assessment of testicular histology. Moreover, blood glucose was evaluated by the glucose oxidase method. In rats treated with streptozotocin (STZ) or aluminium (Al) alone, erosion of testicular parenchyma and stroma was observed. This effect was most severe in diabetic rats simultaneously exposed to Al; coupled with reduced caudal epididymal sperm count that was least in this (STZ+Al) group (18.75 × 10(6)  ml(-1) ) compared with controls (61.25 × 10(6)  ml(-1) ; P < 0.05), STZ group or Al group. Moreover, these reproductive perturbations (in the STZ+Al group) were associated with reduced sperm motility and significantly reduced serum FSH (P < 0.05); but elevated serum T and oestradiol (P < 0.05), compared with control. These suggest that diabetes-induced testicular lesion is exacerbated by simultaneous oral Al toxicity in Wistar rats.
authors.affiliation: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
authors.forename: O B
authors.initials: OB
authors.lastname: Akinola
authors.affiliation: Chemical Pathology and Immunology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
authors.forename: S A
authors.initials: SA
authors.lastname: Biliaminu
authors.affiliation: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
authors.forename: O G
authors.initials: OG
authors.lastname: Adedeji
authors.affiliation: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
authors.forename: B S
authors.initials: BS
authors.lastname: Oluwaseun
authors.affiliation: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
authors.forename: O M
authors.initials: OM
authors.lastname: Olawoyin
authors.affiliation: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
authors.forename: T A
authors.initials: TA
authors.lastname: Adelabu
mesh_terms: D000284:Administration, Oral; D000535:Aluminum / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D002908:Chronic Disease; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000150:complications*; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D015386:Hazardous Substances / Q000008:administration & dosage / Q000633:toxicity*; D006943:Hyperglycemia / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects*; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013311:Streptozocin / Q000633:toxicity; D013737:Testis / Q000187:drug effects / Q000473:pathology*; D013739:Testosterone / Q000097:blood
chemical_list: D015386:Hazardous Substances; D013739:Testosterone; D004958:Estradiol; D013311:Streptozocin; D005640:Follicle Stimulating Hormone; D000535:Aluminum
keywords: Aluminium; diabetes; hyperglycaemia; male fertility; testis