title: Revascularization Induced Maturogenesis of Non-Vital Immature Permanent Tooth Using Platelet-Rich-Fibrin: A Case Report.
abstract: The aim of this report is to describe a novel method of revascularization therapy done in a non-vital, immature permanent tooth using Platelet-rich fibrin (PRF),in a recently developed scaffold material to overcome limitations associated with the traditional method of revascularization using natural blood clot. PRF prepared from autologous blood was placed in the root canal and patient was followed up regularly at one, three, six, nine and 12 months for detailed clinical and radiographic evaluation. At 12 months, radiographic examination revealed root elongation, root end closure, continued thickening of the root dentinal walls, obliteration of root canal space, and normal periradicular anatomy. However, more long term prospective trials and histological studies are highly needed before to testify PRF a panacea for the regenerative endodontic therapy in children.
authors.affiliation: From the Department of Pedodontics and Preventive Dentistry, College of Dental Sciences, Davangere, Karnataka, India.
authors.forename: N B
authors.initials: NB
authors.lastname: Nagaveni
authors.affiliation: From the Department of Pedodontics and Preventive Dentistry, College of Dental Sciences, Davangere, Karnataka, India.
authors.forename: Sidhant
authors.initials: S
authors.lastname: Pathak
authors.affiliation: From the Department of Pedodontics and Preventive Dentistry, College of Dental Sciences, Davangere, Karnataka, India.
authors.forename: P
authors.initials: P
authors.lastname: Poornima
authors.affiliation: From the Department of Pedodontics and Preventive Dentistry, College of Dental Sciences, Davangere, Karnataka, India.
authors.forename: Jooie S
authors.initials: JS
authors.lastname: Joshi
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D056624:Apexification / Q000379:methods*; D001792:Blood Platelets / Q000502:physiology*; D002648:Child; D002939:Ciprofloxacin / Q000008:administration & dosage; D003786:Dental Pulp Cavity / Q000187:drug effects; D003790:Dental Pulp Necrosis / Q000209:etiology / Q000628:therapy; D003804:Dentin / Q000187:drug effects; D004338:Drug Combinations; D005337:Fibrin / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007180:Incisor / Q000187:drug effects* / Q000293:injuries; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008911:Minocycline / Q000008:administration & dosage; D018915:Root Canal Preparation / Q000379:methods; D054457:Tissue Scaffolds; D019227:Tooth Apex / Q000187:drug effects; D014082:Tooth Fractures / Q000150:complications; D019553:Tooth, Nonvital / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D008795:Metronidazole; D002939:Ciprofloxacin; D005337:Fibrin; D008911:Minocycline
keywords: immature teeth; platelet-rich-fibrin; revascularization