title: Sequential meta-C-H olefination of synthetically versatile benzyl silanes: effective synthesis of meta-olefinated toluene, benzaldehyde and benzyl alcohols.
abstract: Tremendous progress has been made towards ortho-selective C-H functionalization in the last three decades. However, the activation of distal C-H bonds and their functionalization has remained fairly underdeveloped. Herein, we report sequential meta-C-H functionalization by performing selective mono-olefination and bis-olefination with late stage modification of the C-Si as well as Si-O bonds. Temporary silyl connection was found to be advantageous due to its easy installation, easy removal and wide synthetic diversification.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076, India. dmaiti@chem.iitb.ac.in.
authors.forename: Tuhin
authors.initials: T
authors.lastname: Patra
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076, India. dmaiti@chem.iitb.ac.in.
authors.forename: Rahul
authors.initials: R
authors.lastname: Watile
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076, India. dmaiti@chem.iitb.ac.in.
authors.forename: Soumitra
authors.initials: S
authors.lastname: Agasti
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076, India. dmaiti@chem.iitb.ac.in.
authors.forename: Togati
authors.initials: T
authors.lastname: Naveen
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076, India. dmaiti@chem.iitb.ac.in.
authors.forename: Debabrata
authors.initials: D
authors.lastname: Maiti