title: Immunohistochemical expression of matrix metalloproteinases in ameloblastomas and pericoronal follicles.
abstract: BACKGROUND
  Ameloblastoma (AM) is a benign odontogenic neoplasm characterized by local invasiveness and recurrence. We compared the immunohistochemical expression of matrix metalloproteinases in different clinical types of AM as well as in normal odontogenic tissue.
  
  
  METHODS
  Thirteen cases of solid AMs, five cases of unicystic AM and eight pericoronal follicles (PF) were selected and subjected to immunohistochemical investigation for matrix metalloproteinase-1, matrix metalloproteinase-2 and matrix metalloproteinase-9 expressions.
  
  
  RESULTS
  The expressions of MMP-1 and MMP-2 were very high in the cytoplasm of cells throughout the entire epithelium and in fibroblasts from the adjacent connective tissue. MMP-9 expression was observed in the same location although with weaker staining. The Kruskal-Wallis test showed statistically significant differences in the epithelial expressions of MMP-1 and MMP-2; there was lower expression among solid AMs when compared with unicystic AM and PF. Compared to both types of AM, higher stromal expression of MMP-9 was found in PF.
  
  
  CONCLUSIONS
  MMP-1, MMP-2 and MMP-9 seem to be associated with AM tumour behaviour as well as physiological tissue remodelling within PF.
authors.affiliation: Postgraduate Program in Dentistry, Health Sciences Center, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
authors.forename: Kamile Leonardi
authors.initials: KL
authors.lastname: Dutra
authors.affiliation: Department of Morphological Sciences, Biological Sciences Center, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
authors.forename: Mabel Mariela Rodríguez
authors.initials: MM
authors.lastname: Cordeiro
authors.affiliation: Department of Pathology, Health Sciences Center, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
authors.forename: Daniella Serafin Couto
authors.initials: DS
authors.lastname: Vieira
authors.affiliation: Department of Pathology, Health Sciences Center, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
authors.forename: Elena Riet Correa
authors.initials: ER
authors.lastname: Rivero
mesh_terms: D000564:Ameloblastoma / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D003238:Connective Tissue / Q000201:enzymology / Q000473:pathology; D003795:Dental Sac / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D004848:Epithelium / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D005347:Fibroblasts / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007573:Jaw Neoplasms / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis; D020782:Matrix Metalloproteinases / Q000096:biosynthesis*; D009364:Neoplasm Recurrence, Local / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D009808:Odontogenic Tumors / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology
chemical_list: D020782:Matrix Metalloproteinases; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1
keywords: ameloblastoma; matrix metalloproteinases; odontogenic tumour; pericoronal follicles