title: Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation.
abstract: OBJECTIVE
  To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation.
  
  
  METHODS
  A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer.
  
  
  METHODS
  Genetic clinics.
  
  
  METHODS
  Detailed information regarding treatment of infertility was collected from a routinely administered questionnaire.
  
  
  METHODS
  None.
  
  
  METHODS
  Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals associated with fertility treatment.
  
  
  RESULTS
  There was no significant relationship between the use of any fertility medication or IVF treatment (odds ratio, 0.66; 95% confidence interval 0.18-2.33) and the subsequent risk of ovarian cancer.
  
  
  CONCLUSIONS
  Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.
authors.affiliation: International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Gronwald
authors.affiliation: CReATe Fertility Centre, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Karen
authors.initials: K
authors.lastname: Glass
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Barry
authors.initials: B
authors.lastname: Rosen
authors.affiliation: Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, West Hollywood, California.
authors.forename: Beth
authors.initials: B
authors.lastname: Karlan
authors.affiliation: Beth Israel Deaconess Medical Center, Boston, Massachusetts.
authors.forename: Nadine
authors.initials: N
authors.lastname: Tung
authors.affiliation: Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Neuhausen
authors.affiliation: Research Group Inherited Cancer, Department of Medical, Genetics, Oslo University Hospital, Oslo, Norway.
authors.forename: Pal
authors.initials: P
authors.lastname: Moller
authors.affiliation: London Regional Cancer Program, London, Ontario, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Ainsworth
authors.affiliation: Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.
authors.forename: Ping
authors.initials: P
authors.lastname: Sun
authors.affiliation: Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada. Electronic address: steven.narod@wchospital.ca.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
authors.affiliation: International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Lubinski
authors.affiliation: Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.
authors.forename: Joanne
authors.initials: J
authors.lastname: Kotsopoulos
mesh_terms: D000328:Adult; D000368:Aged; D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004252:DNA Mutational Analysis; D005260:Female; D005298:Fertility / Q000187:drug effects; D005300:Fertility Agents, Female / Q000008:administration & dosage; D005307:Fertilization in Vitro; D020022:Genetic Predisposition to Disease; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D007315:Insemination, Artificial; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D009154:Mutation; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000235:genetics*; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human; D005300:Fertility Agents, Female
keywords: BRCA1; BRCA2; infertility; in vitro fertilization; ovarian cancer