title: Antibacterial properties of poly (octanediol citrate)/gallium-containing bioglass composite scaffolds.
abstract: Bioactive glasses may function as antimicrobial delivery systems through the incorporation and subsequent release of therapeutic ions. The aim of this study was to evaluate the antimicrobial properties of a series of composite scaffolds composed of poly(octanediol citrate) with increased loads of a bioactive glass that releases zinc (Zn(2+)) and gallium (Ga(3+)) ions in a controlled manner. The antibacterial activity of these scaffolds was investigated against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The ability of the scaffolds to release ions and the subsequent ingress of these ions into hard tissue was evaluated using a bovine bone model. Scaffolds containing bioactive glass exhibited antibacterial activity and this increased in vitro with higher bioactive glass loads; viable cells decreased to about 20 % for the composite scaffold containing 30 % bioactive glass. The Ga(3+) release rate increased as a function of time and Zn(2+) was shown to incorporate into the surrounding bone.
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Zeimaran
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia.
authors.forename: Sara
authors.initials: S
authors.lastname: Pourshahrestani
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Djordjevic
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia.
authors.forename: Belinda
authors.initials: B
authors.lastname: Pingguan-Murphy
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia.
authors.forename: Nahrizul Adib
authors.initials: NA
authors.lastname: Kadri
authors.affiliation: Inamori School of Engineering, Alfred University, Alfred, NY, USA.
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Wren
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia. mtowler@Ryerson.ca.|Department of Mechanical and Industrial Engineering, Faculty of Engineering and Architectural Science, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, Canada. mtowler@Ryerson.ca.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Towler
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D001842:Bone and Bones; D002417:Cattle; D002516:Ceramics; D002951:Citrates; D004926:Escherichia coli / Q000254:growth & development; D005708:Gallium; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D011108:Polymers; D013052:Spectrometry, X-Ray Emission; D013211:Staphylococcus aureus / Q000254:growth & development; D054457:Tissue Scaffolds
chemical_list: D000900:Anti-Bacterial Agents; C022107:Bioglass; D002951:Citrates; D011108:Polymers; C513817:poly(1,8-octanediol citrate); D005708:Gallium