title: Oncogenic MicroRNAs: Key Players in Malignant Transformation.
abstract: MicroRNAs (miRNAs) represent a class of non-coding RNAs that exert pivotal roles in the regulation of gene expression at the post-transcriptional level. MiRNAs are involved in many biological processes and slight modulations in their expression have been correlated with the occurrence of different diseases. In particular, alterations in the expression of miRNAs with oncogenic or tumor suppressor functions have been associated with carcinogenesis, malignant transformation, metastasis and response to anticancer treatments. This review will mainly focus on oncogenic miRNAs whose aberrant expression leads to malignancy.
authors.affiliation: Translational Oncogenomics Laboratory, Regina Elena National Cancer Institute, 00144 Rome, Italy. frixa@ifo.it.
authors.forename: Tania
authors.initials: T
authors.lastname: Frixa
authors.affiliation: Translational Oncogenomics Laboratory, Regina Elena National Cancer Institute, 00144 Rome, Italy. donzelli@ifo.it.
authors.forename: Sara
authors.initials: S
authors.lastname: Donzelli
authors.affiliation: Translational Oncogenomics Laboratory, Regina Elena National Cancer Institute, 00144 Rome, Italy. blandino@ifo.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Blandino
keywords: apoptosis; cancer; cell cycle regulation; oncogenic miRNAs