title: Fibroblast biology in pterygia.
abstract: Activation of fibroblasts is a vital process during wound healing. However, if prolonged and exaggerated, profibrotic pathways lead to tissue fibrosis or scarring and further organ malfunction. Although the pathogenesis of pterygium is known to be multi-factorial, additional studies are needed to better understand the pathways initiated by fibroblast activation for the purpose of therapeutic translation. Regarding pterygium as a possible systemic disorder, we discuss the different cell types that pterygium fibroblasts originate from. These may include bone marrow-derived progenitor cells, cells undergoing epithelial-mesenchymal transition (EMT), and local resident stromal cells. We also describe how pterygium fibroblasts can be activated and perpetuate profibrotic signaling elicited by various proliferative drivers, immune-inflammation, and novel factors such as stromal cell-derived factor-1 (SDF-1) as well as a known key fibrotic factor, transforming growth factor-beta (TGF-β). Finally, epigenetic modification is discussed to explain inherited susceptibility to pterygium.
authors.affiliation: Department of Ophthalmology, Chung-Ang University Hospital, College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul 156-755, South Korea.
authors.forename: Kyoung Woo
authors.initials: KW
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Chung-Ang University Hospital, College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul 156-755, South Korea.
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Park
authors.affiliation: Department of Ophthalmology, Chung-Ang University Hospital, College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul 156-755, South Korea. Electronic address: jck50ey@daum.net.
authors.forename: Jae Chan
authors.initials: JC
authors.lastname: Kim
mesh_terms: D016207:Cytokines / Q000378:metabolism; D044127:Epigenesis, Genetic; D058750:Epithelial-Mesenchymal Transition; D005347:Fibroblasts / Q000473:pathology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D058628:Myofibroblasts / Q000276:immunology / Q000473:pathology*; D011625:Pterygium / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000473:pathology*
chemical_list: D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins
keywords: CXCR4; Fibroblast; Myofibroblast; Pterygium; SDF-1; TGF-β; α-SMA