title: The econobiology of pancreatic acinar cells granule inventory and the stealthy nano-machine behind it.
abstract: The pancreatic gland secretes most of the enzymes and many other macromolecules needed for food digestion in the gastrointestinal tract. These molecules play an important role in digestion, host defense and lubrication. The secretion of pancreatic proteins ensures the availability of the correct mix of proteins when needed. This review describes model systems available for the study of the econobiology of secretory granule content. The secretory pancreatic molecules are stored in large dense-core secretory granules that may undergo either constitutive or evoked secretion, and constitute the granule inventory of the cell. It is proposed that the Golgi complex functions as a distribution center for secretory proteins in pancreatic acinar cells, packing the newly formed secretory molecules into maturing secretory granules, also known functionally as condensing vacuoles. Mathematical modelling brings forward a process underlying granule inventory maintenance at various physiological states of condensation and aggregation by homotypic fusion. These models suggest unique but simple mechanisms accountable for inventory buildup and size, as well as for the distribution of secretory molecules into different secretory pathways in pancreatic acinar cells.
authors.affiliation: Sackler Faculty of Medicine, Department of Pathology, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address: ilanh@patholog.tau.ac.il.
authors.forename: Ilan
authors.initials: I
authors.lastname: Hammel
authors.affiliation: Raymond and Beverly Sackler Faculty of Exact Sciences, School of Mathematical Sciences, Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address: isaco@math.tau.ac.il.
authors.forename: Isaac
authors.initials: I
authors.lastname: Meilijson
mesh_terms: D061354:Acinar Cells / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D003594:Cytoplasmic Granules / Q000502:physiology; D004032:Diet; D006801:Humans; D010179:Pancreas / Q000378:metabolism* / Q000648:ultrastructure; D021381:Protein Transport; D022142:Secretory Vesicles / Q000502:physiology*
keywords: Cellular communication; Econobiology; Homotypic fusion; SNARE; Unit granule