title: Sperm DNA Methylation: Not a Vehicle for Dietary Reprogramming of Offspring?
abstract: Reporting in Developmental Cell, Shea et al. (2015) show, using an inbred mouse strain, that "epivariation"-stochastic individual differences in DNA methylation-is a much greater contributor to the sperm methylome than is diet. They conclude that DNA methylation is not the mechanism underlying the dietary reprogramming of offspring phenotype.
authors.affiliation: Department of Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Melbourne 3086 VIC, Australia. Electronic address: e.whitelaw@latrobe.edu.au.
authors.forename: Emma
authors.initials: E
authors.lastname: Whitelaw
mesh_terms: D000818:Animals; D004275:DNA, Ribosomal / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics*; D014644:Genetic Variation; D016678:Genome / Q000235:genetics*; D008297:Male; D013094:Spermatozoa / Q000378:metabolism*
chemical_list: D004275:DNA, Ribosomal