title: Sex difference of autosomal alleles in populations of European and African descent.
abstract: In the present study, we aimed to report the individual sex-different genetic markers across autosomes in European- and African-origin populations. A total of 8,400 females and 8,081 males in 19 independent cohorts were genotyped across genomes using Illumina or Affymetrix arrays. The allele frequencies were compared between females and males in 9 non-clean cohorts (with some human disease traits) using genome-wide logistic regression and then the nominally significant associations were replicated across 10 clean cohorts (without disease traits). Meta-analysis was performed to derive the combined p values across all cohorts. We found 13 markers that were genome-wide significant (p≤5×10-8) between females and males in the meta-analysis of all cohorts of European descent, including rs7740449 atSYNE1, rs7531151 atPLD5, rs697455 atPPP1R12B, rs6745746 atLOC100128413, rs17000079 atPARM1, rs11948070 atPDE4D, rs7801825 atINSIG1, rs9551642 atMTUS2, rs2932174 atTPTE2, rs1961597 atSALL3, rs4117529 atMETTL4, rs6021473 atSALL4and rs6092466 atRAE1, and one marker, i.e., rs10145208 atPCNX, that was genome-wide significant in the meta-analysis of all cohorts of African descent. The most robust finding was rs7740449 atSYNE1, next toESR1. We conclude that there are many sex-different markers on autosomes. These markers may be informative in differentiating females and males.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA ; VA Connecticut Healthcare System, West Haven Campus, CT, USA.
authors.forename: Lingjun
authors.initials: L
authors.lastname: Zuo
authors.affiliation: Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
authors.affiliation: Provincial Key Laboratory of Translational Cancer Medicine, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, China.
authors.forename: Xiandong
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of EEG & Neuroimaging, Shanghai Mental Health Center, Shanghai, China.
authors.forename: Jijun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Biological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Department of Neurology, Shanghai First People's Hospital, Shanghai Jiao-Tong University, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
authors.forename: Xueqing
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA ; VA Connecticut Healthcare System, West Haven Campus, CT, USA ; Biological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.
authors.forename: Xingguang
authors.initials: X
authors.lastname: Luo
keywords: African; European; Sex-difference; allele; autosome; meta-analysis