title: Response assessment after stereotactic body radiotherapy for spinal metastasis: a report from the SPIne response assessment in Neuro-Oncology (SPINO) group.
abstract: The SPine response assessment In Neuro-Oncology (SPINO) group is a committee of the Response Assessment in Neuro-Oncology working group and comprises a panel of international experts in spine stereotactic body radiotherapy (SBRT). Here, we present the group's first report on the challenges in standardising imaging-based assessment of local control and pain for spinal metastases. We review current imaging modalities used in SBRT treatment planning and tumour assessment and review the criteria for pain and local control in registered clinical trials specific to spine SBRT. We summarise the results of an international survey of the panel to establish the range of current practices in assessing tumour response to spine SBRT. The ultimate goal of the SPINO group is to report consensus criteria for tumour imaging, clinical assessment, and symptom-based response criteria to help standardise future clinical trials.
authors.affiliation: Department of Radiation Oncology, Centre Hospitalier Universitaire de Quebec, Université Laval, Quebec City, QC, Canada.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Thibault
authors.affiliation: Department of Radiation Oncology, University of Southern California, Los Angeles, CA, USA.
authors.forename: Eric L
authors.initials: EL
authors.lastname: Chang
authors.affiliation: Department of Neurosurgery, University of Virginia Health System, Charlottesville, VA, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Sheehan
authors.affiliation: Department of Medical Oncology, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Manmeet S
authors.initials: MS
authors.lastname: Ahluwalia
authors.affiliation: Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland; Department of Radiation Oncology, University Hospital Wuerzburg, Wuerzberg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Guckenberger
authors.affiliation: Department of Neurosurgery, Inje University Ilsan Paik Hospital, Goyang, Korea.
authors.forename: Moon-Jun
authors.initials: MJ
authors.lastname: Sohn
authors.affiliation: Department of Radiation Oncology, Stony Brook University, New York, NY, USA.
authors.forename: Samuel
authors.initials: S
authors.lastname: Ryu
authors.affiliation: Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, QLD, Australia.
authors.forename: Matthew
authors.initials: M
authors.lastname: Foote
authors.affiliation: Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Cleveland, OH, USA.
authors.forename: Simon S
authors.initials: SS
authors.lastname: Lo
authors.affiliation: Department of Neurosurgery, University of Munich Hospital, Munich, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Muacevic
authors.affiliation: Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA, USA.
authors.forename: Scott G
authors.initials: SG
authors.lastname: Soltys
authors.affiliation: Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Samuel
authors.initials: S
authors.lastname: Chao
authors.affiliation: Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Gerszten
authors.affiliation: Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Lis
authors.affiliation: Department of Radiology, University Health Network, Toronto, ON, Canada.
authors.forename: Eugene
authors.initials: E
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Bilsky
authors.affiliation: Department of Orthopedics, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Charles
authors.initials: C
authors.lastname: Fisher
authors.affiliation: Division of Neuro-Oncology, University of Virginia Health System, Charlottesville, VA, USA.
authors.forename: David
authors.initials: D
authors.lastname: Schiff
authors.affiliation: Department of Neurosurgery, Toronto Western Hospital, Toronto, ON, Canada.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Fehlings
authors.affiliation: Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.
authors.forename: Lijun
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Neurosurgery, University of California San Francisco, San Francisco, CA, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Chang
authors.affiliation: Department of Radiation Oncology, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, ON, Canada.
authors.forename: Edward
authors.initials: E
authors.lastname: Chow
authors.affiliation: NCIC Clinical Trials Group Division, Cancer Research Institute, Queen's University Kingston, ON, Canada.
authors.forename: Wendy R
authors.initials: WR
authors.lastname: Parelukar
authors.affiliation: Brain Tumor and Neuro-Oncology Center and Department of Neurosurgery, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Vogelbaum
authors.affiliation: Department of Radiation Oncology, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, ON, Canada. Electronic address: arjun.sahgal@sunnybrook.ca.
authors.forename: Arjun
authors.initials: A
authors.lastname: Sahgal
mesh_terms: D001416:Back Pain / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D003299:Cooperative Behavior; D003952:Diagnostic Imaging / Q000379:methods*; D019538:Health Care Surveys; D006801:Humans; D007391:International Cooperation; D008279:Magnetic Resonance Imaging; D064847:Multimodal Imaging; D010147:Pain Measurement; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D016634:Radiosurgery; D011880:Radiotherapy Planning, Computer-Assisted; D013125:Spinal Neoplasms / Q000150:complications / Q000556:secondary* / Q000601:surgery*; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014916:Whole-Body Irradiation