title: Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats.
abstract: BACKGROUND
  Pleurotus sajor-caju (PSC) is an edible oyster mushroom featuring high nutritional values and pharmacological properties. Objective. To investigate the hypoglycemic and antidiabetic effects of single and repeated oral administration of PSC aqueous extract in normal and diabetic rats.
  
  
  METHODS
  A single dose of 500, 750, or 1000 mg/kg of the PSC extract was given to experimental rats to determine the effects on blood glucose (BG) and oral glucose tolerance test (OGTT). The effective dose (750 mg/kg) of PSC extract was repeatedly administrated daily for 21 days in diabetic rats to examine its antidiabetic effects in terms of BG control, body weight, urine sugar, HbA1c, and several serum profiles.
  
  
  RESULTS
  The dose of 750 mg/kg showed the most significant BG reduction (23.5%) in normal rats 6 hours after administration in BG study (p < 0.05). In OGTT study, the same dose produced a maximum BG fall of 41.3% in normal rats and 36.5% in diabetic rats 3 hours after glucose administration. In 21-day study, treated diabetic rats showed significant improvement in terms of fasting BG, body weight, and urine sugar as compared to control diabetic rats.
  
  
  CONCLUSIONS
  The study evidenced scientifically the beneficial use of PSC as an alternative medicine in diabetes management.
authors.affiliation: Nutrition Program, School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.
authors.forename: Sze Han
authors.initials: SH
authors.lastname: Ng
authors.affiliation: Nutrition Program, School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.
authors.forename: Mohd Shazwan
authors.initials: MS
authors.lastname: Mohd Zain
authors.affiliation: Nutrition Program, School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.
authors.forename: Fatariah
authors.initials: F
authors.lastname: Zakaria
authors.affiliation: Nutrition Program, School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.
authors.forename: Wan Rosli
authors.initials: WR
authors.lastname: Wan Ishak
authors.affiliation: Biomedicine Program, School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.
authors.forename: Wan Amir Nizam
authors.initials: WA
authors.lastname: Wan Ahmad
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000737:chemistry / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000188:drug therapy*; D005951:Glucose Tolerance Test / Q000379:methods; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D020076:Pleurotus / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000494:pharmacology*
chemical_list: D001685:Biological Factors; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013311:Streptozocin