title: Fasting Glucose Levels Correlate with Disease Severity of Guillain-Barré Syndrome.
abstract: OBJECTIVE
  A potential association between diabetes and Guillain-Barré syndrome (GBS) has been indicated by a few case studies. We retrospectively analyzed the clinical features of a large cohort of GBS patients to explore the relationship between the level of fasting plasma glucose (FPG) obtained in the acute phase at admission and the severity of GBS.
  
  
  METHODS
  Three hundred and four GBS patients were divided into two groups, one with normal FPG and the other with high FPG levels according to the international standards of FPG.
  
  
  RESULTS
  The GBS disability scale score was positively, the Medical Research Council (MRC) sum score was negatively correlated to the level of FPG, but not to blood HBA1c or CSF glucose concentrations. A relatively higher FPG level was observed in older and younger GBS patients, and more often in those with cranial nerve involvement, autonomic deficit, dyspnea and ventilator dependence than in patients without these clinical characteristics. Importantly, higher levels of FPG at admission were associated with poorer short-term prognosis measured by the MRC sum score and the GBS disability scale at discharge.
  
  
  CONCLUSIONS
  Our data demonstrates that FPG in the acute phase of GBS correlates with the severity of GBS and may predict the short-term prognosis of GBS.
authors.affiliation: Department of Neurology, the First Hospital of Jilin University, Changchun, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Norman Bethune Health Science Center, Jilin University, Changchun, China.
authors.forename: Guihong
authors.initials: G
authors.lastname: Li
authors.affiliation: Norman Bethune Health Science Center, Jilin University, Changchun, China.
authors.forename: Siyu
authors.initials: S
authors.lastname: Yang
authors.affiliation: Norman Bethune Health Science Center, Jilin University, Changchun, China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Gu
authors.affiliation: Norman Bethune Health Science Center, Jilin University, Changchun, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Li
authors.affiliation: Norman Bethune Health Science Center, Jilin University, Changchun, China.
authors.forename: Mingyang
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Neurology, the First Hospital of Jilin University, Changchun, China.
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Wu
authors.affiliation: Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Guan
authors.affiliation: Division of Neurology, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
authors.forename: Rayomand
authors.initials: R
authors.lastname: Press
authors.affiliation: Department of Neurology, the First Hospital of Jilin University, Changchun, China.|Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Neurology, the First Hospital of Jilin University, Changchun, China.|Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D001786:Blood Glucose