title: Application of stereotactic body radiation therapy to cancer liver metastasis.
abstract: As an accurate external beam irradiation method, stereotactic body radiotherapy (SBRT) has been increasingly used to deliver high dose in less fractions. The liver is one of the most common organs for cancer metastasis. Recently, there have been several trials applying SBRT to cancer liver metastasis and have proved to be effective and safe with local control (LC) rates ranging from 70% to 100% within one or two years and 2-year overall survival (OS) rates ranging from 30% to 38%. Many published studies indicate that SBRT for cancer liver metastasis results in good outcomes without severe toxicities. However, the validated contribution of SBRT to an improved progression-free survival is still missing and more randomized trials should be conducted.
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, 52# Fucheng Road, Beijing 100142, China.
authors.forename: Si-Yuan
authors.initials: SY
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, 52# Fucheng Road, Beijing 100142, China. Electronic address: zgypu63@163.com.
authors.forename: Guang-Ying
authors.initials: GY
authors.lastname: Zhu
authors.affiliation: Second Department of Oncology, General Hospital of Armed Police Forces, Beijing 100039, China.
authors.forename: Gong
authors.initials: G
authors.lastname: Li
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, 52# Fucheng Road, Beijing 100142, China.
authors.forename: Yi-Bao
authors.initials: YB
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, 52# Fucheng Road, Beijing 100142, China.
authors.forename: Jian-Hao
authors.initials: JH
authors.lastname: Geng
mesh_terms: D018450:Disease Progression; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary*; D018579:Patient Selection; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
keywords: Liver; Metastasis and radiotherapy; SBRT