title: Macular Diagnostic Ability in OCT for Assessing Glaucoma in High Myopia.
abstract: OBJECTIVE
  To compare the diagnostic abilities of spectral-domain optical coherence tomography (SD-OCT; Spectralis OCT) and time-domain OCT (TD-OCT; Stratus OCT). Changes in macular parameters in highly myopic eyes of glaucoma patients and highly myopic eyes of glaucoma suspects were evaluated and compared.
  
  
  METHODS
  We collected data from 72 highly myopic eyes (spherical equivalent, ≤-6.0D). Forty-one eyes had perimetric glaucoma and 31 eyes were suspected to have glaucoma (control group). All eyes underwent SD-OCT and TD-OCT imaging. Area under the receiver operating characteristic (AUROC) curve and sensitivity were examined on macular volume and thickness parameters at a fixed specificity and compared between groups.
  
  
  RESULTS
  The highest TD-OCT AUROC curves were found using outer inferior sector macular thickness (AUROC curve, 0.911) and volume (AUROC curve, 0.909). The highest SD-OCT AUROC curves were found using outer inferior region thickness (AUROC curve, 0.836) and volume (AUROC curve, 0.834). The difference between the two imaging modalities was not statistically significant (thickness, p = 0.141; volume, p = 0.138). The sensitivity of TD-OCT macular outer inferior average thickness was highest and was 88.2%, with a specificity of 80.4%. The sensitivity of TD-OCT average volume measurements in this same region was 76.5%, with a specificity of 91.3%. The SD-OCT average thickness measurements also had the highest sensitivity in this region, which was 78.6%, with a specificity of 82.1%. The SD-OCT volume measurements had a sensitivity of 67.9%, with a specificity of 92.3%.
  
  
  CONCLUSIONS
  Both SD-OCT and TD-OCT measurements of outer inferior macular thickness and volume can differentiate between eyes of glaucoma patients and glaucoma suspects with high myopia. These independent predictors all had good sensitivity. Based on our results, SD-OCT and TD-OCT have similar diagnostic abilities. These parameters may provide useful additional data in highly myopic eyes to complement standard glaucoma diagnosis tools.
authors.affiliation: *MD †MD, PhD ‡PhD Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (K-CH, P-CW, Y-CP, H-WC, I-CL, J-CT, P-WL, and M-CT); and Department of Biological Sciences, National Sun Yat-Sen University, Taiwan (H-WC).
authors.forename: Kuo-Chi
authors.initials: KC
authors.lastname: Hung
authors.forename: Pei-Chang
authors.initials: PC
authors.lastname: Wu
authors.forename: Yi-Chieh
authors.initials: YC
authors.lastname: Poon
authors.forename: Hsueh-Wen
authors.initials: HW
authors.lastname: Chang
authors.forename: Ing-Chou
authors.initials: IC
authors.lastname: Lai
authors.forename: Jen-Chia
authors.initials: JC
authors.lastname: Tsai
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Lin
authors.forename: Mei-Ching
authors.initials: MC
authors.lastname: Teng
mesh_terms: D000328:Adult; D019540:Area Under Curve; D003430:Cross-Sectional Studies; D005260:Female; D005901:Glaucoma / Q000175:diagnosis*; D006068:Gonioscopy; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000150:complications*; D009798:Ocular Hypertension / Q000175:diagnosis; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*; D058609:Visual Field Tests