title: Modeling the tumor microenvironment using chitosan-alginate scaffolds to control the stem-like state of glioblastoma cells.
abstract: Better prediction of in vivo drug efficacy using in vitro models should greatly improve in vivo success. Here we utilize 3D highly porous chitosan-alginate complex scaffolds to probe how various components of the glioblastoma microenvironment including extracellular matrix and stromal cells affect tumor cell stem-like state.
authors.affiliation: Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA. mzhang@uw.edu rge@uw.edu.
authors.forename: Forrest M
authors.initials: FM
authors.lastname: Kievit
authors.forename: Kui
authors.initials: K
authors.lastname: Wang
authors.forename: Ariane E
authors.initials: AE
authors.lastname: Erickson
authors.forename: Sheeny K
authors.initials: SK
authors.lastname: Lan Levengood
authors.forename: Richard G
authors.initials: RG
authors.lastname: Ellenbogen
authors.forename: Miqin
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000464:Alginates / Q000737:chemistry*; D045744:Cell Line, Tumor; D048271:Chitosan / Q000737:chemistry* / Q000378:metabolism; D005109:Extracellular Matrix / Q000737:chemistry* / Q000378:metabolism; D005909:Glioblastoma / Q000737:chemistry / Q000378:metabolism*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D014411:Neoplastic Stem Cells / Q000737:chemistry / Q000166:cytology*; D016062:Porosity; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*; D059016:Tumor Microenvironment
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D048271:Chitosan