title: No Significant Effect of Prefrontal tDCS on Working Memory Performance in Older Adults.
abstract: Transcranial direct current stimulation (tDCS) has been put forward as a non-pharmacological alternative for alleviating cognitive decline in old age. Although results have shown some promise, little is known about the optimal stimulation parameters for modulation in the cognitive domain. In this study, the effects of tDCS over the dorsolateral prefrontal cortex (dlPFC) on working memory performance were investigated in thirty older adults. An N-back task assessed working memory before, during and after anodal tDCS at a current strength of 1 mA and 2 mA, in addition to sham stimulation. The study used a single-blind, cross-over design. The results revealed no significant effect of tDCS on accuracy or response times during or after stimulation, for any of the current strengths. These results suggest that a single session of tDCS over the dlPFC is unlikely to improve working memory, as assessed by an N-back task, in old age.
authors.affiliation: Aging Research Center, Karolinska Institutet and Stockholm University Stockholm, Sweden.
authors.forename: Jonna
authors.initials: J
authors.lastname: Nilsson
authors.affiliation: Aging Research Center, Karolinska Institutet and Stockholm University Stockholm, Sweden.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Lebedev
authors.affiliation: Aging Research Center, Karolinska Institutet and Stockholm University Stockholm, Sweden.
authors.forename: Martin
authors.initials: M
authors.lastname: Lövdén
keywords: N-back; aging; plasticity; tDCS; working memory