title: Sex-Dependent Depression-Like Behavior Induced by Respiratory Administration of Aluminum Oxide Nanoparticles.
abstract: Ultrafine aluminum oxide, which are abundant in ambient and involved occupational environments, are associated with neurobehavioral alterations. However, few studies have focused on the effect of sex differences following exposure to environmental Al₂O₃ ultrafine particles. In the present study, male and female mice were exposed to Al₂O₃ nanoparticles (NPs) through a respiratory route. Only the female mice showed depression-like behavior. Although no obvious pathological changes were observed in mice brain tissues, the neurotransmitter and voltage-gated ion channel related gene expression, as well as the small molecule metabolites in the cerebral cortex, were differentially modulated between male and female mice. Both mental disorder-involved gene expression levels and metabolomics analysis results strongly suggested that glutamate pathways were implicated in sex differentiation induced by Al₂O₃ NPs. Results demonstrated the potential mechanism of environmental ultrafine particle-induced depression-like behavior and the importance of sex dimorphism in the toxic research of environmental chemicals.
authors.affiliation: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China. zx_ekin@163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Environmental Health and Endemic Disease Control, Jiangsu Provincial, Center for Disease Prevention and Control, Nanjing 210009, China. cdcxy@vip.sina.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Environmental Health and Endemic Disease Control, Jiangsu Provincial, Center for Disease Prevention and Control, Nanjing 210009, China. jonneylian@163.com.
authors.forename: Lian
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China. Zhangchengcheng2015@hotmail.com.
authors.forename: Chengcheng
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China. mqtmengqingtao@hotmail.com.
authors.forename: Qingtao
authors.initials: Q
authors.lastname: Meng
authors.affiliation: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China. shenshenwu2015@hotmail.com.
authors.forename: Shenshen
authors.initials: S
authors.lastname: Wu
authors.affiliation: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China. shizhiwang2009@hotmail.com.
authors.forename: Shizhi
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Environmental Health and Endemic Disease Control, Jiangsu Provincial, Center for Disease Prevention and Control, Nanjing 210009, China. jscdc@126.com.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Ding
authors.affiliation: Department of Environmental Health and Endemic Disease Control, Jiangsu Provincial, Center for Disease Prevention and Control, Nanjing 210009, China. jscxd@126.com.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China. 101011116@seu.edu.cn.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Li
authors.affiliation: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China. 101011816@seu.edu.cn.
authors.forename: Rui
authors.initials: R
authors.lastname: Chen
mesh_terms: D000280:Administration, Inhalation; D000537:Aluminum Oxide / Q000008:administration & dosage* / Q000633:toxicity*; D000818:Animals; D003863:Depression / Q000209:etiology*; D004781:Environmental Exposure; D005260:Female; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage* / Q000633:toxicity*; D018377:Neurotransmitter Agents; D016273:Occupational Exposure; D010316:Particle Size; D012737:Sex Factors
chemical_list: D018377:Neurotransmitter Agents; D000537:Aluminum Oxide
keywords: aluminum oxide; depressive; glutamate; nanoparticles; sex difference