title: Histogram analysis with automated extraction of brain-tissue region from whole-brain CT images.
abstract: To determine whether an automated extraction of the brain-tissue region from CT images is useful for the histogram analysis of the brain-tissue region was studied. We used the CT images of 11 patients. We developed an automatic brain-tissue extraction algorithm. We evaluated the similarity index of this automated extraction method relative to manual extraction, and we compared the mean CT number of all extracted pixels and the kurtosis and skewness of the distribution of CT numbers of all extracted pixels from the automated and manual extractions. The similarity index was 0.93. The mean CT number and the kurtosis and skewness from the automated extraction were 35.0 Hounsfield units, 0.63, and 0.51, respectively, and were equivalent to those from the manual extraction (35.4 Hounsfield units, 0.59, and 0.46, respectively). The automated extraction of the brain-tissue region from whole-brain CT images was useful for histogram analysis of the brain-tissue region.
authors.affiliation: Department of Medical Technology, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 Japan ; Graduate School of Health Sciences, Kumamoto University, 4-24-1 Kuhonji, Kumamoto, 862-0976 Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kondo
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Yamashita
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 Japan ; Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544 Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiura
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Hiwatash
authors.affiliation: Department of Medical Technology, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 Japan ; Department of Radiological Technology, Kumamoto University Hospital, 1-1-1 Honjyo, Kumamoto, 860-8556 Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Shirasaka
authors.affiliation: Department of Medical Technology, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 Japan.
authors.forename: Hisao
authors.initials: H
authors.lastname: Arimura
authors.affiliation: Department of Medical Technology, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
keywords: Automated extraction; Brain-tissue region; Histogram analysis; Whole-brain CT