title: Fundus autofluorescence findings in central serous chorioretinopathy using two different confocal scanning laser ophthalmoscopes: correlation with functional and structural status.
abstract: OBJECTIVE
  To compare autofluorescence (AF) findings using wide-field (Optomap) and conventional (HRA-AF) confocal scanning laser ophthalmoscopy (cSLO) systems in patients with central serous chorioretinopathy (CSC), and to investigate the correlations between AF findings and functional and anatomical status.
  
  
  METHODS
  Optical coherence tomography (OCT) and AF images were compared in 73 eyes with serous retinal detachment (SRD) (group A) and 30 eyes without SRD (group B). We evaluated AF findings from the SRD region, atrophic area, and foveola. Correlations between AF findings and outer retinal abnormalities in OCT and visual acuity (VA) were analyzed.
  
  
  RESULTS
  Optomap-AF was more effective than HRA-AF in identifying the margins of a detached area (P = 0.001) in group A, and for monitoring mild outer retinal damage (P = 0.041) in group B. The foveolar AF grades in both instruments were significantly correlated with VA and central foveal thickness (CFT) in both group A (Optomap, VA r s = 0.33, P = 0.012; CFT r s = -0.38, P = 0.002; HRA, VA r s = 0.62, P < 0.001; CFT r s = -0.70, P < 0.001) and group B (Optomap, VA r s = 0.71, P < 0.001, CFT r s = -0.78, P < 0.001; HRA, VA r s = 0.40, P = 0.026, CFT r s = -0.40, P = 0.030).
  
  
  CONCLUSIONS
  Optomap-AF was found to be advantageous for monitoring subretinal status in eyes with SRD, and more accurately reflected mild outer retinal changes in eyes without SRD. Foveolar AF grades of both imaging modalities were significantly correlated with functional and anatomical status.
authors.affiliation: Department of Ophthalmology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, South Korea.|Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemun-Gu, Seoul, South Korea, 120-752.
authors.forename: Joo Youn
authors.initials: JY
authors.lastname: Shin
authors.affiliation: Department of Ophthalmology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, South Korea.
authors.forename: Hun Jin
authors.initials: HJ
authors.lastname: Choi
authors.affiliation: Department of Ophthalmology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, South Korea.
authors.forename: Jonghyun
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemun-Gu, Seoul, South Korea, 120-752.
authors.forename: Moonjung
authors.initials: M
authors.lastname: Choi
authors.affiliation: Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemun-Gu, Seoul, South Korea, 120-752.
authors.forename: Byunghoon
authors.initials: B
authors.lastname: Chung
authors.affiliation: Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemun-Gu, Seoul, South Korea, 120-752. Shbyeon@gmail.com.
authors.forename: Suk Ho
authors.initials: SH
authors.lastname: Byeon
mesh_terms: D000328:Adult; D000368:Aged; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis* / Q000503:physiopathology; D002829:Choroid / Q000000981:diagnostic imaging*; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal / Q000379:methods*; D008875:Middle Aged; D019721:Ophthalmoscopes; D015203:Reproducibility of Results; D012160:Retina / Q000000981:diagnostic imaging; D055213:Retinal Pigment Epithelium / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity
keywords: Central serous chorioretinopathy; Fundus autofluorescence; Spectral-domain optical coherence tomography; Wide-field fundus autofluorescence