title: Profilin desensitization: A case series.
abstract: The role of profilin as an allergen has long been questioned. The capacity of profilin to induce respiratory symptoms has recently been demonstrated; moreover, over 50% of patients sensitized to profilin experienced symptoms after the ingestion of plant-derived foods, suggesting that profilin should be considered as a clinically relevant food allergen.We describe the cases of seven allergic patients with oral allergy syndrome and other adverse reactions after eating plant-derived food, that have been undergone to profilin desensitization treatment.The protocol started with a drop of profilin solution (50 µg/mL) diluted 1:10(18) in water until the highest dose of 10 drops of undiluted solution three times a week. At the end of the treatment we observed a decreased mean diameter of profilin wheal in skin prick test (SPT) in five of the seven participants and in profilin specific IgE values in six patients that repeated the test. Regarding basophil activation test (BAT) and the detection of IgG4, we do not have significant results because the tests have to be repeated in some patients. Regarding the double-blind placebo-controlled challenges, after about 10 months of induction phase all the patients showed tolerance to several foods that they previously did not tolerate.Moreover, the immunotherapy with profilin has proved to be safe because no serious adverse events have been reported in our patients.In summary, the results of this exploratory study of sublingual immunotherapy (SLIT) for profilin allergy show that it can be a promising therapeutic option that could modify the clinical reactivity of the patients to the intake of plant-derived food.
authors.affiliation: Allergy Unit, Università Cattolica del Sacro Cuore - Policlinico "A. Gemelli", Rome, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Nucera
authors.affiliation: Allergy Unit, Università Cattolica del Sacro Cuore - Policlinico "A. Gemelli", Rome, Italy aarianna@hotmail.it.
authors.forename: Arianna
authors.initials: A
authors.lastname: Aruanno
authors.affiliation: Allergy Unit, Università Cattolica del Sacro Cuore - Policlinico "A. Gemelli", Rome, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Rizzi
authors.affiliation: Allergy Unit, Università Cattolica del Sacro Cuore - Policlinico "A. Gemelli", Rome, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Pecora
authors.affiliation: Allergy Unit, Università Cattolica del Sacro Cuore - Policlinico "A. Gemelli", Rome, Italy.
authors.forename: Giampiero
authors.initials: G
authors.lastname: Patriarca
authors.affiliation: Allergy Unit, Università Cattolica del Sacro Cuore - Policlinico "A. Gemelli", Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Buonomo
authors.affiliation: Allergy Unit, Università Cattolica del Sacro Cuore - Policlinico "A. Gemelli", Rome, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Mezzacappa
authors.affiliation: Allergy Unit, Università Cattolica del Sacro Cuore - Policlinico "A. Gemelli", Rome, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Schiavino
mesh_terms: D000286:Administration, Sublingual; D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology*; D052179:Antigens, Plant / Q000276:immunology; D003888:Desensitization, Immunologic / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D005512:Food Hypersensitivity / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D008875:Middle Aged; D051304:Profilins / Q000276:immunology* / Q000627:therapeutic use*; D012882:Skin Tests / Q000379:methods
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D051304:Profilins; D007073:Immunoglobulin E
keywords: desensitization; food allergy; profilin