title: WIDESPREAD MACULAR NEUROSENSORY DETACHMENT AFTER OCRIPLASMIN INTRAVITREAL INJECTION.
abstract: OBJECTIVE
  To present the case of a patient with vitreomacular traction who experienced immediate severe acute complications after ocriplasmin intravitreal injection.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 61-year-old woman with vitreomacular traction underwent ocriplasmin treatment. Within 24 hours after injection, she noticed severe reduction in visual acuity. Spectral domain optical coherence tomography revealed release of vitreous traction, together with widespread subretinal fluid and decreased reflectivity in the outer retina. Ten weeks after treatment, visual acuity improved, although below pretreatment levels, with partial reduction in subretinal fluid.
  
  
  CONCLUSIONS
  Intravitreal ocriplasmin can produce acute visual acuity changes with widespread subretinal fluid and outer retinal ellipsoid zone hyporeflectivity on spectral domain optical coherence tomography. The overall acute and long-term safety profile of ocriplasmin remains unknown.
authors.affiliation: King Edward VII Hospital, Windsor, SL4 3DP, United Kingdom.
authors.forename: James E
authors.initials: JE
authors.lastname: Neffendorf
authors.forename: Lik Thai
authors.initials: LT
authors.lastname: Lim
authors.forename: Irina I
authors.initials: II
authors.lastname: Gout
authors.forename: Ahmed
authors.initials: A
authors.lastname: El-Amir
mesh_terms: D005260:Female; D005341:Fibrinolysin / Q000009:adverse effects*; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006801:Humans; D058449:Intravitreal Injections / Q000009:adverse effects; D008875:Middle Aged; D010446:Peptide Fragments / Q000009:adverse effects*; D012163:Retinal Detachment / Q000139:chemically induced*; D014786:Vision Disorders / Q000139:chemically induced*; D020255:Vitreous Detachment / Q000188:drug therapy
chemical_list: D005343:Fibrinolytic Agents; D010446:Peptide Fragments; C054561:microplasmin; D005341:Fibrinolysin