title: Epidemiological Research on Hand, Foot, and Mouth Disease in Mainland China.
abstract: Hand, foot, and mouth disease (HFMD), which has led to millions of attacks and several outbreaks across the world and become more predominant in Asia-Pacific Region, especially in Mainland China, is caused by several Human Enteroviruses including new enterovirus, coxsakievirus and echovirus. In recent years, much research has focused on the epidemiological characteristics of HFMD. In this article, multiple characteristics of HFMD such as basic epidemiology, etiology and molecular epidemiology; influencing factors; detection; and surveillance are reviewed, as these can be help protect high risks groups, prevalence prediction and policy making for disease prevention.
authors.affiliation: Department of Virology, School of Public Health, Shandong University, Jinan 250012, China. dennis.eyre@hotmail.com.
authors.forename: Zhi-Chao
authors.initials: ZC
authors.lastname: Zhuang
authors.affiliation: Shandong Center for Disease Control and Prevention, Jinan 250014, China. jack-cou@163.com.
authors.forename: Zeng-Qiang
authors.initials: ZQ
authors.lastname: Kou
authors.affiliation: Department of Virology, School of Public Health, Shandong University, Jinan 250012, China. 201413969@mail.sdu.edu.cn.
authors.forename: Yong-Juan
authors.initials: YJ
authors.lastname: Bai
authors.affiliation: Qilu Hospital of Shandong University, Jinan 250012, China. cxonway1107@163.com.
authors.forename: Xiang
authors.initials: X
authors.lastname: Cong
authors.affiliation: Department of Virology, School of Public Health, Shandong University, Jinan 250012, China. 201514148@mail.sdu.edu.cn.
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Wang
authors.affiliation: Department of Virology, School of Public Health, Shandong University, Jinan 250012, China. 201514134@mail.sdu.edu.cn.
authors.forename: Chun
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Virology, School of Public Health, Shandong University, Jinan 250012, China. dlzhl@sdu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Virology, School of Public Health, Shandong University, Jinan 250012, China. yuxuejie@sdu.edu.cn.|Center for Biodefense and Emerging Infectious Diseases, Departments of Pathology and Microbiology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0609, USA. yuxuejie@sdu.edu.cn.
authors.forename: Xue-Jie
authors.initials: XJ
authors.lastname: Yu
authors.affiliation: Department of Virology, School of Public Health, Shandong University, Jinan 250012, China. zhiyu.wang@sdu.edu.cn.
authors.forename: Zhi-Yu
authors.initials: ZY
authors.lastname: Wang
authors.affiliation: Department of Virology, School of Public Health, Shandong University, Jinan 250012, China. wenhongling@sdu.edu.cn.
authors.forename: Hong-Ling
authors.initials: HL
authors.lastname: Wen
mesh_terms: D002681:China / Q000453:epidemiology; D004770:Enterovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D062665:Epidemiological Monitoring; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D015994:Incidence; D008297:Male; D017720:Molecular Epidemiology; D015995:Prevalence; D012621:Seasons
keywords: HFMD; enterovirus; epidemiology; etiology; influencing factor