title: Probing the Limits of Selectivity in a Recognition-Mediated Reaction Network Embedded within a Dynamic Covalent Library.
abstract: Two recognition-mediated reaction processes operating through reactive binary complexes drive resolution of a 24-component dynamic covalent library, assembled from individual aldehydes and nucleophiles. The effectiveness of the library resolution and selective amplification of one recognition-enabled species over another is limited by the difference in the rates of the recognition-mediated reactive processes and the strength of the recognition processes employed in the dynamic system.
authors.affiliation: School of Chemistry and EaStCHEM, University of St. Andrews, North Haugh, St. Andrews, KY16 9ST, UK.
authors.forename: Tamara
authors.initials: T
authors.lastname: Kosikova
authors.affiliation: School of Chemistry and EaStCHEM, University of St. Andrews, North Haugh, St. Andrews, KY16 9ST, UK.|UCB, 216 Bath Road, Slough, Berks, SL1 3WE, UK.
authors.forename: Harry
authors.initials: H
authors.lastname: Mackenzie
authors.affiliation: School of Chemistry and EaStCHEM, University of St. Andrews, North Haugh, St. Andrews, KY16 9ST, UK. d.philp@st-andrews.ac.uk.
authors.forename: Douglas
authors.identifier: http://orcid.org/0000-0002-9198-4302
authors.initials: D
authors.lastname: Philp
keywords: NMR spectroscopy; combinatorial chemistry; cycloaddition reaction; kinetics; molecular recognition