title: Commentary on Inhaled (239)PUO2 in Dogs - A Prophylaxis Against Lung Cancer?
abstract: Several studies on the effect of inhaled plutonium-dioxide particulates and the incidence of lung tumors in dogs reveal beneficial effects when the cumulative alpha-radiation dose is low. There is a threshold at an exposure level of about 100 cGy for excess tumor incidence and reduced lifespan. The observations conform to the expectations of the radiation hormesis dose-response model and contradict the predictions of the LNT hypothesis. These studies suggest investigating the possibility of employing low-dose alpha-radiation, such as from (239)PuO2 inhalation, as a prophylaxis against lung cancer.
authors.affiliation: Cuttler & Associates Inc.
authors.forename: Jerry M
authors.initials: JM
authors.lastname: Cuttler
authors.affiliation: Brookhaven National Laboratory, Biological, Environmental & Climate Sciences.
authors.forename: Ludwig E
authors.initials: LE
authors.lastname: Feinendegen
keywords: adaptive protection; inhalation; lung cancer; plutonium-dioxide; prophylaxis; radiation hormesis