title: The differential effects of green tea on dose-dependent doxorubicin toxicity.
abstract: BACKGROUND
  Doxorubicin (DOX) is an anticancer drug displaying cardiac and hepatic adverse effects mostly dependent on oxidative stress. Green tea (GT) has been reported to play a protective role in diseases resulting from oxidative stress.
  
  
  OBJECTIVE
  The objective of this study was to evaluate if GT protects against DOX-induced oxidative stress, heart and liver morphological changes, and metabolic disorders.
  
  
  METHODS
  Male Wistar rats received intraperitoneal injection of DOX (1.0 or 2.0 mg/kg b.w.) for 7 weeks or concomitantly GT extract soluble in drinking water.
  
  
  RESULTS
  There were multidirectional effects of GT on blood metabolic parameters changed by DOX. Among all tested biochemical parameters, statistically significant protection of GT against DOX-induced changes was revealed in case of blood fatty acid-binding protein, brain natriuretic peptide, and superoxide dismutase.
  
  
  CONCLUSIONS
  DOX caused oxidative stress in both organs. It was inhibited by GT in the heart but remained unchanged in the liver. DOX-induced general toxicity and histopathological changes in the heart and in the liver were mitigated by GT at a higher dose of DOX and augmented in rats treated with a lower dose of the drug.
authors.affiliation: Department of Pneumology, Oncology and Alergology, Medical University of Lublin, Lublin, Poland.
authors.forename: Slawomir
authors.initials: S
authors.lastname: Mandziuk
authors.affiliation: Independent Medical Biology Unit, Medical University of Lublin, Lublin, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Gieroba
authors.affiliation: Independent Medical Biology Unit, Medical University of Lublin, Lublin, Poland; a.korg@interia.pl.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Korga
authors.affiliation: Department of Histology and Embryology, Medical University of Lublin, Lublin, Poland.
authors.forename: Wlodzimierz
authors.initials: W
authors.lastname: Matysiak
authors.affiliation: Department of Histology and Embryology, Medical University of Lublin, Lublin, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Jodlowska-Jedrych
authors.affiliation: Department of Anatomy, Medical University of Lublin, Lublin, Poland.
authors.forename: Franciszek
authors.initials: F
authors.lastname: Burdan
authors.affiliation: Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Poleszak
authors.affiliation: 1st Department of Anaesthesiology and Intensive Care, Medical University of Lublin, Lublin, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Kowalczyk
authors.affiliation: 1st Department of Radiology and Nuclear Medicine, Medical University of Lublin, Lublin, Poland.
authors.forename: Luiza
authors.initials: L
authors.lastname: Grzycka-Kowalczyk
authors.affiliation: Department of Clinical Pathomorphology, Medical University of Lublin, Lublin, Poland.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Korobowicz
authors.affiliation: Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, Lublin, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Jozefczyk
authors.affiliation: Independent Medical Biology Unit, Medical University of Lublin, Lublin, Poland.
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Dudka
keywords: cardiotoxicity; catechins; doxorubicin; green tea; oxidative stress