title: [Pathological complete response: A predictive survival factor after neoadjuvant chemotherapy in lung cancer].
abstract: The phase III trials of adjuvant and neoadjuvant chemotherapy showed a 5 % increase survival but the clinical research in this area is difficult because the duration of the trials with overall survival as primary end point is around 10years. To shorten the duration of these studies, the use of surrogate end points such as disease-free survival or relapse-free survival is possible, but does not significantly reduce the duration of studies. Several studies in and outside the lung cancer showed histological complete response or the percentage of viable tumor cells after chemotherapy could be correlated with survival and thus become an interesting alternative criterion. If this is verified, clinical studies of preoperative chemotherapy should be shortened which would allow patients faster access to innovative treatment in the perioperative situation.
authors.affiliation: Intergroupe francophone de cancérologie pulmonaire, 10, rue de la Grange-Batelière, 75009 Paris, France. Electronic address: bernard.milleron@ifct.fr.
authors.forename: Bernard
authors.initials: B
authors.lastname: Milleron
authors.affiliation: CHU de Besançon, service de pneumologie, 25000 Besançon, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Westeel
authors.affiliation: AP-HP, hôpital Bichat, service d'oncologie pulmonaire, 75018 Paris, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Gounant
authors.affiliation: AP-HP, hôpital Tenon, service de pneumologie, 75020 Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Wislez
authors.affiliation: CHU de Strasbourg, service de pneumologie, 67000 Strasbourg, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Quoix
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy / Q000401:mortality; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D060828:Induction Chemotherapy; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local; D011300:Preoperative Care; D011643:Publishing; D012004:Rectal Neoplasms / Q000188:drug therapy; D013997:Time Factors
keywords: Carcinome bronchique non à petites cellules; Chimiothérapie néoadjuvante; Chirurgie; Complete response; Neoadjuvant chemotherapy; Non-small cell lung cancer; Prognosis; Pronostic; Réponse complète; Surgery