title: Engineering of radiolabeled iron oxide nanoparticles for dual-modality imaging.
abstract: Over the last decade, radiolabeled iron oxide nanoparticles have been developed as promising contrast agents for dual-modality positron emission tomography/magnetic resonance imaging (PET/MRI) or single-photon emission computed tomography/magnetic resonance imaging (SPECT/MRI). The combination of PET (or SPECT) with MRI can offer synergistic advantages for noninvasive, sensitive, high-resolution, and quantitative imaging, which is suitable for early detection of various diseases such as cancer. Here, we summarize the recent advances on radiolabeled iron oxide nanoparticles for dual-modality imaging, through the use of a variety of PET (and SPECT) isotopes by using both chelator-based and chelator-free radiolabeling techniques. WIREs Nanomed Nanobiotechnol 2016, 8:619-630. doi: 10.1002/wnan.1386.
authors.affiliation: School of Mechanical & Electrical Engineering, Nanchang University, Jiangxi, China.|Department of Radiology, University of Wisconsin - Madison, Madison, WI, USA.
authors.forename: Fanrong
authors.initials: F
authors.lastname: Ai
authors.affiliation: Department of Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, USA.
authors.forename: Carolina A
authors.initials: CA
authors.lastname: Ferreira
authors.affiliation: Department of Radiology, University of Wisconsin - Madison, Madison, WI, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Radiology, University of Wisconsin - Madison, Madison, WI, USA.|Department of Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, USA.|Department of Medical Physics, University of Wisconsin - Madison, Madison, WI, USA.|Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.
authors.forename: Weibo
authors.initials: W
authors.lastname: Cai
mesh_terms: D000818:Animals; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051379:Mice; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals
chemical_list: D058185:Magnetite Nanoparticles; D019275:Radiopharmaceuticals