title: Total Synthesis of Cyclomarin A, a Marine Cycloheptapeptide with Anti-Tuberculosis and Anti-Malaria Activity.
abstract: An efficient synthetic protocol for the stereoselective synthesis of cyclomarin A is reported. Key steps in the syntheses of the building blocks are an asymmetric chelate-enolate Claisen rearrangement, an asymmetric hydrogenation, and highly diastereoselective additions of organozinc and -titanium reagents.
authors.affiliation: Organic Chemistry I, Saarland University , Campus Building C4.2, D-66123 Saarbrücken, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Barbie
authors.affiliation: Organic Chemistry I, Saarland University , Campus Building C4.2, D-66123 Saarbrücken, Germany.
authors.forename: Uli
authors.initials: U
authors.lastname: Kazmaier
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006865:Hydrogenation; D008288:Malaria / Q000188:drug therapy; D008386:Marine Biology; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000962:Antimalarials; D009842:Oligopeptides; C459019:cyclomarin A