title: Bicyclic heterocyclic anthranilic diamides as ryanodine receptor modulators with insecticidal activity.
abstract: The diamide insecticides act on the ryanodine receptor (RyR). The synthesis of various bicyclic anthranilic derivatives is reported. Their activity against the insect ryanodine receptor (RyR) and their insecticidal activity in the greenhouse is presented, as well as structure activity relationship considerations.
authors.affiliation: Syngenta AG, Crop Protection Research, Chemistry, Schwarzwaldallee 215, CH-4058 Basel, Switzerland; Syngenta Crop Protection Muenchwilen AG, Schaffhauserstrasse, CH-4332 Stein, Switzerland. Electronic address: andre.jeanguenat@syngenta.com.
authors.forename: André
authors.initials: A
authors.lastname: Jeanguenat
authors.affiliation: Syngenta AG, Crop Protection Research, Chemistry, Schwarzwaldallee 215, CH-4058 Basel, Switzerland.
authors.forename: Patricia
authors.initials: P
authors.lastname: Durieux
authors.affiliation: Syngenta AG, Crop Protection Research, Chemistry, Schwarzwaldallee 215, CH-4058 Basel, Switzerland; Syngenta Crop Protection Muenchwilen AG, Schaffhauserstrasse, CH-4332 Stein, Switzerland.
authors.forename: Andrew J F
authors.initials: AJ
authors.lastname: Edmunds
authors.affiliation: Syngenta AG, Crop Protection Research, Chemistry, Schwarzwaldallee 215, CH-4058 Basel, Switzerland; Syngenta Crop Protection Muenchwilen AG, Schaffhauserstrasse, CH-4332 Stein, Switzerland.
authors.forename: Roger G
authors.initials: RG
authors.lastname: Hall
authors.affiliation: Syngenta, Jealotts Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK.
authors.forename: Dave
authors.initials: D
authors.lastname: Hughes
authors.affiliation: Syngenta AG, Crop Protection Research, Chemistry, Schwarzwaldallee 215, CH-4058 Basel, Switzerland; Syngenta Crop Protection Muenchwilen AG, Schaffhauserstrasse, CH-4332 Stein, Switzerland.
authors.forename: Olivier
authors.initials: O
authors.lastname: Loiseleur
authors.affiliation: Syngenta Research and Technology Centre, Santa Monica Works, Corlim, Goa 403110, India.
authors.forename: Jagadish
authors.initials: J
authors.lastname: Pabba
authors.affiliation: Syngenta AG, Crop Protection Research, Chemistry, Schwarzwaldallee 215, CH-4058 Basel, Switzerland; Syngenta Crop Protection Muenchwilen AG, Schaffhauserstrasse, CH-4332 Stein, Switzerland.
authors.forename: André
authors.initials: A
authors.lastname: Stoller
authors.affiliation: Syngenta AG, Crop Protection Research, Chemistry, Schwarzwaldallee 215, CH-4058 Basel, Switzerland; Syngenta Crop Protection Muenchwilen AG, Schaffhauserstrasse, CH-4332 Stein, Switzerland.
authors.forename: Stephan
authors.initials: S
authors.lastname: Trah
authors.affiliation: Syngenta AG, Crop Protection Research, Chemistry, Schwarzwaldallee 215, CH-4058 Basel, Switzerland.
authors.forename: Jean
authors.initials: J
authors.lastname: Wenger
authors.affiliation: Syngenta Crop Protection Muenchwilen AG, Schaffhauserstrasse, CH-4332 Stein, Switzerland.
authors.forename: Anna
authors.initials: A
authors.lastname: Dutton
authors.affiliation: Syngenta, Jealotts Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Crossthwaite
mesh_terms: D000818:Animals; D001042:Aphids; D003958:Diamide / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism*; D018411:Spodoptera / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D019837:Ryanodine Receptor Calcium Release Channel; D062367:ortho-Aminobenzoates; C031385:anthranilic acid; D003958:Diamide
keywords: Anthranilamides; Diamides; Insecticide; Ryanodine receptor