title: Targeted Analysis Reveals an Important Role of JAK-STAT-SOCS Genes for Milk Production Traits in Australian Dairy Cattle.
abstract: The Janus kinase and signal transducer and activator of transcription (JAK-STAT) pathway genes along with suppressors of cytokine signalling (SOCS) family genes play a crucial role in controlling cytokine signals in the mammary gland and thus mammary gland development. Mammary gene expression studies showed differential expression patterns for all the JAK-STAT pathway genes. Gene expression studies using qRT-PCR revealed differential expression of SOCS2, SOCS4, and SOCS5 genes across the lactation cycle in dairy cows. Using genotypes from 1,546 Australian Holstein-Friesian bulls, a statistical model for an association analysis based on SNPs within 500 kb of JAK-STAT pathway genes, and SOCS genes alone was constructed. The analysis suggested that these genes and pathways make a significant contribution to the Australian milk production traits. There were 24 SNPs close to SOCS1, SOCS3, SOCS5, SOCS7, and CISH genes that were significantly associated with Australian Profit Ranking (APR), Australian Selection Index (ASI), and protein yield (PY). This study supports the view that there may be some merit in choosing SNPs around functionally relevant genes for the selection and genetic improvement schemes for dairy production traits.
authors.affiliation: Faculty of Veterinary Science, University of Sydney, NSW Sydney, Australia.
authors.forename: Sondur J
authors.initials: SJ
authors.lastname: Arun
authors.affiliation: Faculty of Veterinary Science, University of Sydney, NSW Sydney, Australia.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Thomson
authors.affiliation: Faculty of Veterinary Science, University of Sydney, NSW Sydney, Australia.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Sheehy
authors.affiliation: Faculty of Veterinary Science, University of Sydney, NSW Sydney, Australia.
authors.forename: Mehar S
authors.initials: MS
authors.lastname: Khatkar
authors.affiliation: Faculty of Veterinary Science, University of Sydney, NSW Sydney, Australia.
authors.forename: Herman W
authors.initials: HW
authors.lastname: Raadsma
authors.affiliation: Faculty of Veterinary Science, University of Sydney, NSW Sydney, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Williamson
keywords: JAK-STAT pathway genes; SOCS family genes; association mapping; dairy traits; qRT-PCR