title: Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties.
abstract: A water-soluble template-assembled synthetic G-quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramolecular folds alone in solution. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase-type biocatalytic activities and improved quadruplex-interacting properties. Comparison of its DNAzyme-boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme-boosting agent.
authors.affiliation: Université Grenoble Alpes, Département de Chimie Moléculaire, CNRS UMR 5250, 38041, Grenoble, France.
authors.forename: Theodore
authors.initials: T
authors.lastname: Flack
authors.affiliation: Université Grenoble Alpes, Département de Chimie Moléculaire, CNRS UMR 5250, 38041, Grenoble, France.
authors.forename: Thibaut
authors.initials: T
authors.lastname: Constantin
authors.affiliation: Université Grenoble Alpes, Département de Chimie Moléculaire, CNRS UMR 5250, 38041, Grenoble, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Penasse
authors.affiliation: Université Grenoble Alpes, Département de Chimie Moléculaire, CNRS UMR 5250, 38041, Grenoble, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Dejeu
authors.affiliation: Université Grenoble Alpes, Département de Chimie Moléculaire, CNRS UMR 5250, 38041, Grenoble, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Gennaro
authors.affiliation: Université Grenoble Alpes, Département de Chimie Moléculaire, CNRS UMR 5250, 38041, Grenoble, France.
authors.forename: Muriel
authors.initials: M
authors.lastname: Jourdan
authors.affiliation: Institut de Chimie Moléculaire, Université de Bourgogne (ICMUB), CNRS UMR 6302, 21078, Dijon, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Laguerre
authors.affiliation: Institut de Chimie Moléculaire, Université de Bourgogne (ICMUB), CNRS UMR 6302, 21078, Dijon, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Pirrotta
authors.affiliation: Institut de Chimie Moléculaire, Université de Bourgogne (ICMUB), CNRS UMR 6302, 21078, Dijon, France.
authors.forename: David
authors.identifier: http://orcid.org/0000-0002-3056-9295
authors.initials: D
authors.lastname: Monchaud
authors.affiliation: Université Grenoble Alpes, Département de Chimie Moléculaire, CNRS UMR 5250, 38041, Grenoble, France. Nicolas.Spinelli@ujf-grenoble.fr.
authors.forename: Nicolas
authors.identifier: http://orcid.org/0000-0002-6857-011X
authors.initials: N
authors.lastname: Spinelli
authors.affiliation: Université Grenoble Alpes, Département de Chimie Moléculaire, CNRS UMR 5250, 38041, Grenoble, France.
authors.forename: Eric
authors.identifier: http://orcid.org/0000-0002-3911-6241
authors.initials: E
authors.lastname: Defrancq
mesh_terms: D055162:Biocatalysis; D021881:DNA, Catalytic / Q000737:chemistry* / Q000378:metabolism; D054856:G-Quadruplexes; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D012996:Solutions / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D021881:DNA, Catalytic; D012996:Solutions; D014867:Water
keywords: DNAzyme; G-quadruplexes; G-quartets; cyclodecapeptide; supramolecular chemistry