title: Consolidating a Distributed Compound Management Capability into a Single Installation: The Application of Overall Equipment Effectiveness to Determine Capacity Utilization.
abstract: Compound management (CM) is a critical discipline enabling hit discovery through the production of assay-ready compound plates for screening. CM in pharma requires significant investments in manpower, capital equipment, repairs and maintenance, and information technology. These investments are at risk from external factors, for example, new technology rendering existing equipment obsolete and strategic site closures. At AstraZeneca, we faced the challenge of evaluating the number of CM sites required to support hit discovery in response to site closures and pressure on our operating budget. We reasoned that overall equipment effectiveness, a tool used extensively in the manufacturing sector, could determine the equipment capacity and appropriate number of sites. We identified automation downtime as the critical component governing capacity, and a connection between automation downtime and the availability of skilled staff. We demonstrated that sufficient production capacity existed in two sites to meet hit discovery demand without the requirement for an additional investment of $7 million in new facilities. In addition, we developed an automated capacity model that incorporated an extended working-day pattern as a solution for reducing automation downtime. The application of this solution enabled the transition to a single site, with an annual cost saving of $2.1 million.
authors.affiliation: Discovery Sciences, Innovative Medicines, AstraZeneca R&D, Macclesfield, UK Clive.Green@astrazeneca.com.
authors.forename: Clive
authors.initials: C
authors.lastname: Green
authors.affiliation: Operations Quality, Global Operations, AstraZeneca R&D, Macclesfield, UK.
authors.forename: Daniel
authors.initials: D
authors.lastname: Taylor
mesh_terms: D057205:Automation, Laboratory / Q000191:economics* / Q000379:methods*; D003365:Costs and Cost Analysis; D004353:Drug Evaluation, Preclinical / Q000191:economics* / Q000379:methods*; D057166:High-Throughput Screening Assays / Q000191:economics* / Q000379:methods*
keywords: automation downtime; capacity utilization; compound management; hit discovery; overall equipment effectiveness