title: RIFM fragrance ingredient safety assessment, Eugenol, CAS Registry Number 97-53-0.
abstract: The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Reproductive toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 230 mg/kg/day. A gavage multigenerational continuous breeding study conducted in rats on a suitable read across analog resulted in a MOE of 12,105 while considering 22.6% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. Electronic address: AApi@rifm.org.
authors.forename: A M
authors.initials: AM
authors.lastname: Api
authors.affiliation: Member RIFM Expert Panel, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY 10032, USA.
authors.forename: D
authors.initials: D
authors.lastname: Belsito
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: S
authors.initials: S
authors.lastname: Bhatia
authors.affiliation: Member RIFM Expert Panel, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo SE-20502, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Bruze
authors.affiliation: Member RIFM Expert Panel, Humphrey School of Public Affairs, University of Minnesota, 301 19th Avenue South, Minneapolis, MN 55455, USA.
authors.forename: P
authors.initials: P
authors.lastname: Calow
authors.affiliation: Member RIFM Expert Panel, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. Dr. Orlando Marques de Paiva, 87, Sao Paulo CEP 05508-900, Brazil.
authors.forename: M L
authors.initials: ML
authors.lastname: Dagli
authors.affiliation: Member RIFM Expert Panel, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078 Würzburg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Dekant
authors.affiliation: Member RIFM Expert Panel, Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Fryer
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: L
authors.initials: L
authors.lastname: Kromidas
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: S
authors.initials: S
authors.lastname: La Cava
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Lalko
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: A
authors.initials: A
authors.lastname: Lapczynski
authors.affiliation: Member RIFM Expert Panel, Vanderbilt University School of Medicine, Department of Biochemistry, Center in Molecular Toxicology, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN 37232-0146, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Liebler
authors.affiliation: Member RIFM Expert Panel, Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Miyachi
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: V T
authors.initials: VT
authors.lastname: Politano
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: G
authors.initials: G
authors.lastname: Ritacco
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: D
authors.initials: D
authors.lastname: Salvito
authors.affiliation: Member RIFM Expert Panel, The University of Tennessee, College of Veterinary Medicine, Department of Comparative Medicine, 2407 River Dr., Knoxville, TN 37996-4500, USA.
authors.forename: T W
authors.initials: TW
authors.lastname: Schultz
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: J
authors.initials: J
authors.lastname: Shen
authors.affiliation: Member RIFM Expert Panel, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ 85724-5050, USA.
authors.forename: I G
authors.initials: IG
authors.lastname: Sipes
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: B
authors.initials: B
authors.lastname: Wall
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: D K
authors.initials: DK
authors.lastname: Wilcox
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000633:toxicity*; D003257:Consumer Product Safety; D004249:DNA Damage / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D023381:Endpoint Determination; D005054:Eugenol / Q000737:chemistry / Q000633:toxicity*; D019055:No-Observed-Adverse-Effect Level; D010476:Perfume / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D018570:Risk Assessment; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D000890:Anti-Infective Agents; D010476:Perfume; D005054:Eugenol
keywords: Environmental safety; Genotoxicity; Local respiratory toxicity; Phototoxicity/photoallergenicity; Repeated dose; Reproductive and developmental toxicity; Skin sensitization