title: Semen cryopreservation and usage rate for assisted reproductive technology in 898 men with cancer.
abstract: An undesired side effect of cancer treatment is potential subfertility or infertility. Timely cryopreservation of semen is the best modality to ensure fertility. This retrospective data analysis established the usage rate of cryopreserved semen from cancer patients. Pubertal and post-pubertal patients who could become infertile as a result of cancer (treatment) were offered the option to cryopreserve semen prior to treatment. Of the 898 patients who cryopreserved their semen in our hospital, 96 (10.7%) used this for assisted reproductive technology. The live birth rates for intrauterine insemination, in-vitro fertilization, intracytoplasmic sperm injection and cryopreserved embryo transfer were 13%, 29%, 32% and 17%, respectively. Of all couples involved, 77% achieved parenthood, i.e. 60 of the 78 patients (with complete follow-up) fathered at least one child.
authors.affiliation: Department of Urology, University Medical Centre Utrecht, Utrecht, The Netherlands. Electronic address: mulleriris@gmail.com.
authors.forename: Iris
authors.initials: I
authors.lastname: Muller
authors.affiliation: Department of Reproductive Medicine and Gynaecology, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: Ralph J A
authors.initials: RJ
authors.lastname: Oude Ophuis
authors.affiliation: Department of Reproductive Medicine and Gynaecology, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: Frank J M
authors.initials: FJ
authors.lastname: Broekmans
authors.affiliation: Department of Urology, University Medical Centre Utrecht, Utrecht, The Netherlands; Department of Urology, Central Military Hospital, Utrecht, The Netherlands.
authors.forename: Tycho M T W
authors.initials: TM
authors.lastname: Lock
mesh_terms: D000328:Adult; D015925:Cryopreservation / Q000379:methods*; D004624:Embryo Transfer / Q000379:methods; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D007248:Infertility, Male / Q000150:complications* / Q000628:therapy*; D007315:Insemination, Artificial / Q000379:methods; D008297:Male; D009369:Neoplasms / Q000150:complications* / Q000503:physiopathology; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012661:Semen / Q000166:cytology*; D012662:Semen Preservation; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods; D016896:Treatment Outcome
keywords: assisted reproductive technology; cancer; cryopreservation; semen; usage rate