title: Computer-Aided Decision Support for Melanoma Detection Applied on Melanocytic and Nonmelanocytic Skin Lesions: A Comparison of Two Systems Based on Automatic Analysis of Dermoscopic Images.
abstract: Commercially available clinical decision support systems (CDSSs) for skin cancer have been designed for the detection of melanoma only. Correct use of the systems requires expert knowledge, hampering their utility for nonexperts. Furthermore, there are no systems to detect other common skin cancer types, that is, nonmelanoma skin cancer (NMSC). As early diagnosis of skin cancer is essential, there is a need for a CDSS that is applicable to all types of skin lesions and is suitable for nonexperts. Nevus Doctor (ND) is a CDSS being developed by the authors. We here investigate ND's ability to detect both melanoma and NMSC and the opportunities for improvement. An independent test set of dermoscopic images of 870 skin lesions, including 44 melanomas and 101 NMSCs, were analysed by ND. Its sensitivity to melanoma and NMSC was compared to that of Mole Expert (ME), a commercially available CDSS, using the same set of lesions. ND and ME had similar sensitivity to melanoma. For ND at 95% melanoma sensitivity, the NMSC sensitivity was 100%, and the specificity was 12%. The melanomas misclassified by ND at 95% sensitivity were correctly classified by ME, and vice versa. ND is able to detect NMSC without sacrificing melanoma sensitivity.
authors.affiliation: Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, 9038 Tromsø, Norway.
authors.forename: Kajsa
authors.initials: K
authors.lastname: Møllersen
authors.affiliation: Private Office, Venloer Straße 107, 50259 Pulheim, Germany.
authors.forename: Herbert
authors.initials: H
authors.lastname: Kirchesch
authors.affiliation: Department of Mathematics and Statistics, UiT The Arctic University of Norway, 9037 Tromsø, Norway.
authors.forename: Maciel
authors.initials: M
authors.lastname: Zortea
authors.affiliation: Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, 9038 Tromsø, Norway.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Schopf
authors.affiliation: Department of Mathematics and Statistics, UiT The Arctic University of Norway, 9037 Tromsø, Norway.
authors.forename: Kristian
authors.initials: K
authors.lastname: Hindberg
authors.affiliation: Department of Mathematics and Statistics, UiT The Arctic University of Norway, 9037 Tromsø, Norway.
authors.forename: Fred
authors.initials: F
authors.lastname: Godtliebsen
mesh_terms: D003658:Decision Making, Computer-Assisted; D046169:Dermoscopy; D003937:Diagnosis, Differential; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology; D009508:Nevus, Pigmented / Q000175:diagnosis / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology