title: Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient.
abstract: WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. Crystalline lattices of polyomavirus-like particles were observed in the patient's lung by electron microscopy. WUPyV was detected in the lung and other tissues by real-time quantitative PCR and identified in the lung and trachea by immunohistochemistry. A subset of WUPyV-positive cells in the lung had morphologic features of macrophages. Although the role of WUPyV as a human pathogen remains unclear, these results clearly demonstrate evidence for infection of respiratory tract tissues in this patient.
authors.forename: Erica A
authors.initials: EA
authors.lastname: Siebrasse
authors.forename: Nang L
authors.initials: NL
authors.lastname: Nguyen
authors.forename: Melisa J
authors.initials: MJ
authors.lastname: Willby
authors.forename: Dean D
authors.initials: DD
authors.lastname: Erdman
authors.forename: Marilyn A
authors.initials: MA
authors.lastname: Menegus
authors.forename: David
authors.initials: D
authors.lastname: Wang
mesh_terms: D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008168:Lung / Q000821:virology*; D011120:Polyomavirus / Q000302:isolation & purification*; D027601:Polyomavirus Infections / Q000175:diagnosis*; D012141:Respiratory Tract Infections / Q000821:virology*; D066027:Transplant Recipients
keywords: WU polyomavirus; epithelial cells; immunosuppression; transplant; tropism; viruses