title: Plant cell culture strategies for the production of natural products.
abstract: Plants have evolved a vast chemical cornucopia to support their sessile lifestyles. Man has exploited this natural resource since Neolithic times and currently plant-derived chemicals are exploited for a myriad of applications. However, plant sources of most high-value natural products (NPs) are not domesticated and therefore their production cannot be undertaken on an agricultural scale. Further, these plant species are often slow growing, their populations limiting, the concentration of the target molecule highly variable and routinely present at extremely low concentrations. Plant cell and organ culture constitutes a sustainable, controllable and environmentally friendly tool for the industrial production of plant NPs. Further, advances in cell line selection, biotransformation, product secretion, cell permeabilisation, extraction and scale-up, among others, are driving increases in plant NP yields. However, there remain significant obstacles to the commercial synthesis of high-value chemicals from these sources. The relatively recent isolation, culturing and characterisation of cambial meristematic cells (CMCs), provides an emerging platform to circumvent many of these potential difficulties. [BMB Reports 2016; 49(3): 149-158].
authors.affiliation: Institute of Molecular Plant Sciences, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.
authors.forename: Marisol
authors.initials: M
authors.lastname: Ochoa-Villarreal
authors.affiliation: Institute of Molecular Plant Sciences, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.
authors.forename: Susan
authors.initials: S
authors.lastname: Howat
authors.affiliation: Unhwa Corp., Jeonju 55017, Korea.
authors.forename: SunMi
authors.initials: S
authors.lastname: Hong
authors.affiliation: Unhwa Corp., Jeonju 55017, Korea.
authors.forename: Mi Ok
authors.initials: MO
authors.lastname: Jang
authors.affiliation: Unhwa Corp., Jeonju 55017, Korea.
authors.forename: Young-Woo
authors.initials: YW
authors.lastname: Jin
authors.affiliation: Unhwa Corp., Jeonju 55017, Korea.
authors.forename: Eun-Kyong
authors.initials: EK
authors.lastname: Lee
authors.affiliation: Institute of Molecular Plant Sciences, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Loake
mesh_terms: D001688:Biological Products / Q000378:metabolism*; D001711:Biotransformation; D018929:Cell Culture Techniques / Q000379:methods*; D018914:Cells, Immobilized / Q000378:metabolism; D059828:Plant Cells / Q000378:metabolism*; D018517:Plant Roots / Q000166:cytology
chemical_list: D001688:Biological Products