title: Diversity oriented synthesis for novel anti-malarials.
abstract: Malaria a global pandemic has engulfed nearly 0.63 million people globally. It is high time that a cure for malaria is required to stop its ever increasing menace. Our commentary discusses the advent and contribution of diversity oriented synthesis (DOS) in the drug discovery efforts towards developing cure for malaria. DOS based on chemical genetics focusses on design and synthesis of molecular libraries which covers large tracts of biologically relevant chemical space. Herein we will discuss the applications, advantages, disadvantages and future directions of DOS with respect to malaria.
authors.affiliation: Department of Chemistry, School of Natural Science, Shiv Nadar University, Village Chithera, Tehsil Dadri, District Gautam Buddha Nagar, 201314 UP India.
authors.forename: Chandramohan
authors.initials: C
authors.lastname: Bathula
authors.affiliation: Department of Life Science, School of Natural Science, Shiv Nadar University, Village Chithera, Tehsil Dadri, District Gautam Buddha Nagar, 201314 UP India.
authors.forename: Shailja
authors.initials: S
authors.lastname: Singh
authors.affiliation: Department of Chemistry, School of Natural Science, Shiv Nadar University, Village Chithera, Tehsil Dadri, District Gautam Buddha Nagar, 201314 UP India.
authors.forename: Subhabrata
authors.initials: S
authors.lastname: Sen
keywords: Chemical genetics; Diversity oriented synthesis; Michael addition; Phenotypic screening