title: A New Antimicrobial Prenylated Benzo-lactone from the Rhizome of Cissus cornifolia.
abstract: BACKGROUND
  Medicinal plants remain one of the largest reservoirs of new bioactive compounds. In this study, a new prenylated benzo-lactone (4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxypentyl)-2-benzofuran-1(3H)-one) was isolated from the acetone extracts of the rhizome of Cissus cornifolia. The antimicrobial activity of the compound was evaluated against some microorganisms including Staphylococcus aureus, Salmonella typhi, and Candida albicans.
  
  
  METHODS
  The acetone extracts of the rhizome of C. cornifolia was separated and purified by various chromatographic techniques. The structure of the isolated compound was characterized by analysis of spectral data including one and two-dimensional nuclear magnetic resonance.
  
  
  RESULTS
  The isolated compound was characterized as (4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxypentyl)-2-benzofuran-1(3H)-one), it showed activity against 6 out of 10 tested clinical isolates of some microorganisms including S. aureus, S. typhi, and C. albicans. The inhibition zones ranged between 17 mm and 25 mm. The inhibition zones observed compare favorably with the positive control used.
  
  
  CONCLUSIONS
  The compound could serve as a lead for the development of more potent antimicrobial agent. To the best of our knowledge, this is the first report of the isolation and characterization as well as antimicrobial screening of the compound.
authors.affiliation: Department of Pharmaceutical and Medicinal Chemistry, Zaria, Nigeria.
authors.forename: Aliyu M
authors.initials: AM
authors.lastname: Musa
authors.affiliation: Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: Nasir
authors.initials: N
authors.lastname: Tajuddeen
authors.affiliation: Department of Pharmaceutical and Medicinal Chemistry, Zaria, Nigeria.
authors.forename: Abdullahi Y
authors.initials: AY
authors.lastname: Idris
authors.affiliation: Department of Pharmaceutical and Medicinal Chemistry, Zaria, Nigeria.
authors.forename: Abdurahman Y
authors.initials: AY
authors.lastname: Rafindadi
authors.affiliation: Department of Pharmaceutical and Medicinal Chemistry, Usmanu Danfodio University, Sokoto, Nigeria.
authors.forename: Musa I
authors.initials: MI
authors.lastname: Abdullahi
authors.affiliation: Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: Abubakar B
authors.initials: AB
authors.lastname: Aliyu
authors.affiliation: Directorate of research, Nigeria Institute of Leather and Science Technology, Zaria, Nigeria.
authors.forename: Mikhail S
authors.initials: MS
authors.lastname: Abdullahi
authors.affiliation: Department of Biochemistry Ahmadu Bello University, Zaria, Nigeria.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Ibrahim
keywords: Antimicrobial; Benzo-Lactone; Cissus cornifolia; Prenylated