title: Long noncoding RNAs in lung cancer: what we know in 2015.
abstract: Lung cancer ranks as the first most common cancer and the first leading cause of cancer-related death in China and worldwide. Due to the difficulty in early diagnosis and the onset of cancer metastasis, the 5-year survival rate of lung cancer remains extremely low. Long noncoding RNAs (lncRNAs), which lacking protein-coding ability, have recently emerged as pivotal participants in biological processes, often dysregulated in a range of cancers, including lung cancer. In this review, we highlight the recent findings of lncRNAs in lung cancer pathogenesis. While our understanding of lncRNAs in the onset and progression of lung cancer is still in its infancy, there is no doubt that understanding the activities of lncRNAs will certainly secure strong biomarkers and improve treatment options for lung cancer patients.
authors.affiliation: Department of Chemotherapy, Zhejiang Cancer Hospital, 310022, Hangzhou, China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, Sir Run Run Show Hospital, School of Medicine, Zhejiang University, 310016, Hangzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Chemotherapy, Zhejiang Cancer Hospital, 310022, Hangzhou, China. 21972483@qq.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Fan
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding
keywords: Lung cancer; NSCLC; lncRNA