title: Synthesis of highly enantio-enriched stereoisomers of hydroxy-GR24.
abstract: In contrast to a biomimetic electrophilic cyclisation cascade, we employ a contra-biomimetic nucleophilic cyclisation cascade to give the tricyclic core of 4-hydroxy-GR24 in a single step. Kinetic resolution using a stereoselective Noyori transfer hydrogenation enables the concise synthesis of any enantiomerically enriched 4-hydroxy-GR24 stereoisomer.
authors.affiliation: School of Chemistry, The University of Sydney, NSW 2006, Australia. christopher.mcerlean@sydney.edu.au.
authors.forename: J C
authors.initials: JC
authors.lastname: Morris
authors.forename: C S P
authors.initials: CS
authors.lastname: McErlean