title: Living Cell Factories - Electrosprayed Microcapsules and Microcarriers for Minimally Invasive Delivery.
abstract: Minimally invasive delivery of "living cell factories" consisting of cells and therapeutic agents has gained wide attention for next generation biomaterial device systems for multiple applications including musculoskeletal tissue regeneration, diabetes and cancer. Cellular-based microcapsules and microcarrier systems offer several attractive features for this particular purpose. One such technology capable of generating these types of systems is electrohydrodynamic (EHD) spraying. Depending on various parameters, including applied voltage, biomaterial properties (viscosity, conductivity) and needle geometry, complex structures and arrangements can be fabricated for therapeutic strategies. The advances in the use of EHD technology are outlined, specifically in the manipulation of bioactive and dynamic material systems to control size, composition and configuration in the development of minimally invasive micro-scaled biopolymeric systems. The exciting therapeutic applications of this technology, future perspectives and associated challenges are also presented.
authors.affiliation: Trinity Center for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.|Department of Mechanical Engineering, School of Engineering, Trinity College Dublin, Ireland.
authors.forename: Syeda M
authors.initials: SM
authors.lastname: Naqvi
authors.affiliation: Trinity Center for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.|School of Medicine, Trinity College Dublin, Ireland.
authors.forename: Srujana
authors.initials: S
authors.lastname: Vedicherla
authors.affiliation: Trinity Center for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.|Department of Mechanical Engineering, School of Engineering, Trinity College Dublin, Ireland.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Gansau
authors.affiliation: Trinity Center for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.|School of Medicine, Trinity College Dublin, Ireland.
authors.forename: Tom
authors.initials: T
authors.lastname: McIntyre
authors.affiliation: Trinity Center for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.
authors.forename: Michelle
authors.initials: M
authors.lastname: Doherty
authors.affiliation: Trinity Center for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.|Department of Mechanical Engineering, School of Engineering, Trinity College Dublin, Ireland.
authors.forename: Conor T
authors.initials: CT
authors.lastname: Buckley
mesh_terms: D001672:Biocompatible Materials; D002214:Capsules / Q000737:chemistry*; D014783:Viscosity
chemical_list: D001672:Biocompatible Materials; D002214:Capsules
keywords: electrohydrodynamic; hydrogels; microcapsules, core-shell; microcarriers