title: A 15-day course of donepezil modulates spectral EEG dynamics related to target auditory stimuli in young, healthy adult volunteers.
abstract: To identify possible electroencephalographic (EEG) markers of donepezil's effect on cortical activity in young, healthy adult volunteers at the group level.
  
  
  
  Thirty subjects were administered a daily dose of either 5mg donepezil or placebo for 15days in a double-blind, randomized, cross-over trial. The electroencephalogram during an auditory oddball paradigm was recorded from 58 scalp electrodes. Current source density (CSD) transformations were applied to EEG epochs. The event-related potential (ERP), inter-trial coherence (ITC: the phase consistency of the EEG spectrum) and event-related spectral perturbation (ERSP: the EEG power spectrum relative to the baseline) were calculated for the target (oddball) stimuli.
  
  
  
  The donepezil and placebo conditions differed in terms of the changes in delta/theta/alpha/beta ITC and ERSP in various regions of the scalp (especially the frontal electrodes) but not in terms of latency and amplitude of the P300-ERP component.
  
  
  
  Our results suggest that ITC and ERSP analyses can provide EEG markers of donepezil's effects in young, healthy, adult volunteers at a group level.
  
  
  
  Novel EEG markers could be useful to assess the therapeutic potential of drug candidates in Alzheimer's disease in healthy volunteers prior to the initiation of Phase II/III clinical studies in patients.
authors.affiliation: INSERM U1171, Lille University Medical Center, Lille, France; Department of Clinical Neurophysiology, Lille University Medical Center, Lille, France. Electronic address: christopher.leroy87@gmail.com.
authors.forename: Christopher
authors.initials: C
authors.lastname: Leroy
authors.affiliation: INSERM U1171, Lille University Medical Center, Lille, France; Department of Clinical Neurophysiology, Lille University Medical Center, Lille, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Bourriez
authors.affiliation: INSERM U1171, Lille University Medical Center, Lille, France; Department of Neurology and Movement Disorders, Lille University Medical Center, Lille, France.
authors.forename: Kathy
authors.initials: K
authors.lastname: Dujardin
authors.affiliation: INSERM U1171, Lille University Medical Center, Lille, France; Department of Clinical Neurophysiology, Lille University Medical Center, Lille, France.
authors.forename: Behnam
authors.initials: B
authors.lastname: Molaee-Ardekani
authors.affiliation: Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy; Department of Neuroscience, IRCCS San Raffaele Pisana, Rome, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Babiloni
authors.affiliation: INSERM U1171, Lille University Medical Center, Lille, France; Department of Medical Pharmacology, Lille University Medical Center, Lille, France; CIC 1403 INSERM-CHU, Lille University Medical Center, Lille, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Deplanque
authors.affiliation: INSERM U1171, Lille University Medical Center, Lille, France; Department of Medical Pharmacology, Lille University Medical Center, Lille, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Ponchel
authors.affiliation: INSERM U1171, Lille University Medical Center, Lille, France; Department of Clinical Neurophysiology, Lille University Medical Center, Lille, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Hennion
authors.affiliation: INSERM U1171, Lille University Medical Center, Lille, France; Department of Clinical Neurophysiology, Lille University Medical Center, Lille, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Plomhause
authors.affiliation: Department of Clinical Neurophysiology, Lille University Medical Center, Lille, France; ULCO, Calais, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Devanne
authors.affiliation: INSERM U1171, Lille University Medical Center, Lille, France; Department of Medical Pharmacology, Lille University Medical Center, Lille, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Deguil
authors.affiliation: INSERM UMR 825 Brain Imaging and Neurological Dysfunctions, Toulouse, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Payoux
authors.affiliation: Department of Clinical Pharmacology, and CNRS UMR 7289, CIC-CPCET, Aix-Marseille University, Marseille, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Blin
authors.affiliation: INSERM UMR 825 Brain Imaging and Neurological Dysfunctions, Toulouse, France.
authors.forename: Déborah
authors.initials: D
authors.lastname: Méligne
authors.affiliation: Department of Clinical Pharmacology, and CNRS UMR 7289, CIC-CPCET, Aix-Marseille University, Marseille, France.
authors.forename: Joëlle
authors.initials: J
authors.lastname: Micallef
authors.affiliation: INSERM UMR 825 Brain Imaging and Neurological Dysfunctions, Toulouse, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Chauveau
authors.affiliation: Department of Clinical Pharmacology, and CNRS UMR 7289, CIC-CPCET, Aix-Marseille University, Marseille, France.
authors.forename: Laura
authors.initials: L
authors.lastname: Lanteaume
authors.affiliation: INSERM UMR 825 Brain Imaging and Neurological Dysfunctions, Toulouse, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Vervueren
authors.affiliation: Department of Clinical Pharmacology, and CNRS UMR 7289, CIC-CPCET, Aix-Marseille University, Marseille, France.
authors.forename: François
authors.initials: F
authors.lastname: Guimont
authors.affiliation: Department of Medical Pharmacology, INSERM CIC 1436, Toulouse University Medical Center, Toulouse, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Thalamas
authors.affiliation: Department of Clinical Pharmacology, and CNRS UMR 7289, CIC-CPCET, Aix-Marseille University, Marseille, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Cassé-Perrot
authors.affiliation: Department of Clinical Pharmacology, and CNRS UMR 7289, CIC-CPCET, Aix-Marseille University, Marseille, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Rouby
authors.affiliation: INSERM U1171, Lille University Medical Center, Lille, France; Department of Medical Pharmacology, Lille University Medical Center, Lille, France.
authors.forename: Régis
authors.initials: R
authors.lastname: Bordet
authors.affiliation: INSERM U1171, Lille University Medical Center, Lille, France; Department of Clinical Neurophysiology, Lille University Medical Center, Lille, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Derambure
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001921:Brain / Q000187:drug effects*; D018592:Cross-Over Studies; D000077265:Donepezil / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects*; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D018697:Nootropic Agents; D000077265:Donepezil
keywords: Donepezil; EEG markers; Event-related potential; Event-related spectral perturbation; Inter-trial coherence