title: Evaluation of the in vitro activity of flumequine against field isolates of Brachyspira hyodysenteriae.
abstract: Flumequine is a quinolone derivative used in veterinary medicine to treat enteric infections, mainly those caused by Gram negative bacteria and also some Gram positive. Some recent reports by field practitioners have suggested that its use in swine dysentery outbreaks can minimize the impact of this disease. This study aims to evaluate the in vitro anti-Brachyspira hyodysenteriae activity of flumequine. Forty eight field isolates of the bacterium were evaluated using a microdilution test. The lack of colon bioavailability studies of flumequine in pigs makes it difficult to establish the true efficacy of this antibiotic for swine dysentery control. Nonetheless, the relatively high values of MIC50 (50 μg/mL) and MBC50 (50 μg/mL) obtained suggest poor activity against B. hyodysenteriae. Flumequine activity in swine dysentery outbreaks could be related to its activity against other bacteria, different from B. hyodysenteriae, engaged in swine dysentery pathogenesis.
authors.affiliation: Infectious Diseases and Epidemiology Unit, Faculty of Veterinary, University of León, 24071 León, Spain. Electronic address: lallm@unileon.es.
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Aller-Morán
authors.affiliation: Infectious Diseases and Epidemiology Unit, Faculty of Veterinary, University of León, 24071 León, Spain.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Martínez-Lobo
authors.affiliation: Infectious Diseases and Epidemiology Unit, Faculty of Veterinary, University of León, 24071 León, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Rubio
authors.affiliation: Infectious Diseases and Epidemiology Unit, Faculty of Veterinary, University of León, 24071 León, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Carvajal
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017401:Brachyspira hyodysenteriae / Q000187:drug effects*; D024841:Fluoroquinolones / Q000494:pharmacology*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; C012976:flumequine
keywords: Brachyspira hyodysenteriae; Flumequine; Quinolone; Swine dysentery