title: [Differentiation Study of Chinese Medical Syndrome Typing for Diarrhea-predominant Irritable Bowel Syndrome Based on Information of Four Chinese Medical Diagnostic Methods and Brain-gut Peptides].
abstract: OBJECTIVE
  To establish discriminant functions of diarrhea-predominant irritable bowel syndrome (IBS-D) by studying it from quantitative diagnosis angle, hoping to reduce interference of subjective factors in diagnosing and differentially diagnosing Chinese medical syndromes of IBS-D.
  
  
  METHODS
  A Chinese medical clinical epidemiological survey was carried out in 439 IBS-D patients using Clinical Information Collection Table of IBS. Initial syndromes were obtained by cluster analysis. They were analyzed using step-by-step discrimination by taking information of four Chinese medical diagnostic methods and serum brain-gut peptides (BGP) as variables.
  
  
  RESULTS
  Clustering results were Gan stagnation Pi deficiency syndrome (GSPDS), Pi-Wei weakness syndrome (PWWS), Gan stagnation qi stasis syndrome (GSQSS), Pi-Shen yang deficiency syndrome (PSYDS), Pi-Wei damp-heat syndrome (PWDHS), cold-damp disturbing Pi syndrome (CDDPS). Of them, GSPDS was mostly often seen with effective percentage of 34. 2%, while CDDPS was the least often seen with effective percentage of 5.5%. A total of 5 discriminant functions for GSPDS, PWWS, GSQSS, PSYDS, and PWDHS were obtained by step-by-step dis- crimination method. The retrospective misjudgment rate was 4.1% (16/390), while the cross-validation misjudgment rate was 15.4% (60/390).
  
  
  CONCLUSIONS
  The establishment of discriminant functions is of value in objectively diagnosing and differentially diagnosing Chinese medical syndromes of IBS-D.
authors.forename: Hao-meng
authors.initials: HM
authors.lastname: Wu
authors.forename: Zhi-wei
authors.initials: ZW
authors.lastname: Xu
authors.forename: Hai-qing
authors.initials: HQ
authors.lastname: Ao
authors.forename: Ya-fei
authors.initials: YF
authors.lastname: Shi
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Hu
authors.forename: Yun-peng
authors.initials: YP
authors.lastname: Ji
mesh_terms: D000067531:Alarmins; D001921:Brain; D016000:Cluster Analysis; D003967:Diarrhea / Q000145:classification / Q000175:diagnosis*; D006358:Hot Temperature; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000145:classification / Q000175:diagnosis*; D008516:Medicine, Chinese Traditional; D019413:Qi; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D016711:Yang Deficiency
chemical_list: D000067531:Alarmins