title: Pelvic MRI findings in relapsed prostate cancer after radical prostatectomy.
abstract: OBJECTIVE
  Little is known about the clinical impact of using multiparametric MRI to plan early salvage radiotherapy after radical prostatectomy. We aimed to evaluate the incidence and location of recurrence based on pelvic multiparametric MRI findings and to identify clinical variables predictive of positive imaging results.
  
  
  METHODS
  We defined radiological criteria of local and lymph node malignancy and reviewed records and MRI studies of 70 patients with PSA recurrence after radical prostatectomy. We performed univariate and multivariate analysis to identify any association between clinical, pathological and treatment-related variables and imaging results.
  
  
  RESULTS
  Multiparametric MRI was positive in 33/70 patients. We found local and lymph node recurrence in 27 patients and 7 patients, respectively, with a median PSA value of 0.38 ng/ml. We found no statistically significant differences between patients with positive and negative multiparametric MRI for any variable. Shorter PSADT was associated with positive lymph nodes (median PSADT: 5.12 vs 12.70 months; p: 0.017).
  
  
  CONCLUSIONS
  Nearly half the patients had visible disease in multiparametric MRI despite low PSA. Positive lymph nodes incidence should be considered when planning salvage radiotherapy, particularly in patients with a short PSADT.
authors.affiliation: Department of Radiology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Quintí, 89, 08041, Barcelona, Spain. dhernandez@santpau.cat.
authors.forename: D
authors.initials: D
authors.lastname: Hernandez
authors.affiliation: Department of Urology, Fundació Puigvert, Universitat Autònoma de Barcelona, Cartagena Str. 340-350, 08025, Barcelona, Spain. dsalas@fundacio-puigvert.es.
authors.forename: D
authors.initials: D
authors.lastname: Salas
authors.affiliation: Department of Radiation Oncology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Quintí, 89, 08041, Barcelona, Spain. dgimenezv@gmail.com.
authors.forename: D
authors.initials: D
authors.lastname: Giménez
authors.affiliation: Department of Radiation Oncology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Quintí, 89, 08041, Barcelona, Spain. docpaulis@hotmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Buitrago
authors.affiliation: Department of Urology, Fundació Puigvert, Universitat Autònoma de Barcelona, Cartagena Str. 340-350, 08025, Barcelona, Spain. sesquena@fundacio-puigvert.es.
authors.forename: S
authors.initials: S
authors.lastname: Esquena
authors.affiliation: Department of Urology, Fundació Puigvert, Universitat Autònoma de Barcelona, Cartagena Str. 340-350, 08025, Barcelona, Spain. jpalou@fundacio-puigvert.es.
authors.forename: J
authors.initials: J
authors.lastname: Palou
authors.affiliation: Department of Radiology, Fundació Puigvert, Universitat Autònoma de Barcelona, Cartagena Str. 340-350, 08025, Barcelona, Spain. pdelatorre@fundacio-puigvert.es.
authors.forename: P
authors.initials: P
authors.lastname: de la Torre
authors.affiliation: Department of Radiology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Quintí, 89, 08041, Barcelona, Spain. jpernas@santpau.cat.
authors.forename: J
authors.initials: J
authors.lastname: Pernas
authors.affiliation: Department of Clinical Epidemiology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Quintí, 89, 08041, Barcelona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Gich
authors.affiliation: Department of Radiation Oncology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Quintí, 89, 08041, Barcelona, Spain. ggomez@santpau.cat.
authors.forename: G Gómez
authors.initials: GG
authors.lastname: de Segura
authors.affiliation: Department of Radiation Oncology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Quintí, 89, 08041, Barcelona, Spain. jcraven@santpau.cat.
authors.forename: J
authors.initials: J
authors.lastname: Craven-Bartle
authors.affiliation: Department of Radiation Oncology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Quintí, 89, 08041, Barcelona, Spain. gsancho@santpau.cat.
authors.forename: G
authors.initials: G
authors.lastname: Sancho
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008207:Lymphatic Metastasis / Q000473:pathology* / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000532:radiotherapy; D010388:Pelvis / Q000473:pathology; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D011878:Radiotherapy / Q000379:methods; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods