title: Modeling psychiatric disorders with patient-derived iPSCs.
abstract: Psychiatric disorders are heterogeneous disorders characterized by complex genetics, variable symptomatology, and anatomically distributed pathology, all of which present challenges for effective treatment. Current treatments are often blunt tools used to ameliorate the most severe symptoms, often at the risk of disrupting functional neural systems, thus there is a pressing need to develop rational therapeutics. Induced pluripotent stem cells (iPSCs) reprogrammed from patient somatic cells offer an unprecedented opportunity to recapitulate both normal and pathologic human tissue and organ development, and provides new approaches for understanding disease mechanisms and for drug discovery with higher predictability of their effects in humans. Here we review recent progress and challenges in using human iPSCs for modeling neuropsychiatric disorders and developing novel therapeutic strategies.
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Zhexing
authors.initials: Z
authors.lastname: Wen
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Kimberly M
authors.initials: KM
authors.lastname: Christian
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Song
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: gming1@jhmi.edu.
authors.forename: Guo-li
authors.initials: GL
authors.lastname: Ming
mesh_terms: D000067877:Autism Spectrum Disorder / Q000235:genetics / Q000503:physiopathology; D001321:Autistic Disorder / Q000235:genetics / Q000503:physiopathology; D001714:Bipolar Disorder / Q000235:genetics / Q000503:physiopathology; D002872:Chromosome Deletion; D025063:Chromosome Disorders / Q000235:genetics / Q000503:physiopathology; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D003865:Major Depressive Disorder / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D008133:Long QT Syndrome / Q000235:genetics / Q000503:physiopathology; D001523:Mental Disorders / Q000235:genetics* / Q000503:physiopathology; D008959:Models, Neurological; D015518:Rett Syndrome / Q000235:genetics / Q000503:physiopathology; D012559:Schizophrenia / Q000235:genetics / Q000503:physiopathology; D013576:Syndactyly / Q000235:genetics / Q000503:physiopathology; D018980:Williams Syndrome / Q000235:genetics / Q000503:physiopathology