title: Pathophysiology of Pulmonary Hypertension in Chronic Parenchymal Lung Disease.
abstract: Pulmonary hypertension commonly complicates chronic obstructive pulmonary disease and interstitial lung disease. The association of chronic lung disease and pulmonary hypertension portends a worse prognosis. The pathophysiology of pulmonary hypertension differs in the presence or absence of lung disease. We describe the physiological determinants of the normal pulmonary circulation to better understand the pathophysiological factors implicated in chronic parenchymal lung disease-associated pulmonary hypertension. This review will focus on the pathophysiology of 3 forms of chronic lung disease-associated pulmonary hypertension: idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and sarcoidosis.
authors.affiliation: Division of Pulmonary and Critical Care, Department of Medicine, Weill Cornell Medical Center, New York, NY. Electronic address: ins9021@nyp.org.
authors.forename: Inderjit
authors.initials: I
authors.lastname: Singh
authors.affiliation: Division of Pulmonary and Critical Care, Department of Medicine, Weill Cornell Medical Center, New York, NY.
authors.forename: Kevin Cong
authors.initials: KC
authors.lastname: Ma
authors.affiliation: Division of Pulmonary and Critical Care, Department of Medicine, Weill Cornell Medical Center, New York, NY.
authors.forename: David Adam
authors.initials: DA
authors.lastname: Berlin
mesh_terms: D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology*; D054990:Idiopathic Pulmonary Fibrosis / Q000150:complications*; D011652:Pulmonary Circulation; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications*; D012507:Sarcoidosis / Q000150:complications*
keywords: Chronic obstructive pulmonary disease; Idiopathic pulmonary fibrosis; Pulmonary fibrosis; Pulmonary hypertension; Sarcoidosis