title: Infective endocarditis and cancer in the elderly.
abstract: Little is known about the magnitude of the association between infective endocarditis and cancer, and about the natural history of cancer patients with concomitant diagnosis of infective endocarditis. We used the SEER-Medicare linked database to identify individuals aged 65 years or more diagnosed with colorectal, lung, breast, or prostate cancer, and without any cancer diagnosis (5% random Medicare sample from SEER areas) between 1992 and 2009. We identified infective endocarditis from the ICD-9 diagnosis of each admission recorded in the Medpar file and its incidence rate 90 days around cancer diagnosis. We also estimated the overall survival and CRC-specific survival after a concomitant diagnosis of infective endocarditis. The peri-diagnostic incidence of infective endocarditis was 19.8 cases per 100,000 person-months for CRC, 5.7 cases per 100,000 person-months for lung cancer, 1.9 cases per 100,000 person-months for breast cancer, 4.1 cases per 100,000 person-months for prostate cancer and 2.4 cases per 100,000 person-months for individuals without cancer. Two-year overall survival was 46.4% (95% CI 39.5, 54.5%) for stage I-III CRC patients with concomitant endocarditis and 73.1% (95 % CI 72.9, 73.3%) for those without it. In this elderly population, the incidence of infective endocarditis around CRC diagnosis was substantially higher than around the diagnosis of lung, breast and prostate cancers. A concomitant diagnosis of infective endocarditis in patients with CRC diagnosis is associated with shorter survival.
authors.affiliation: Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA. xabi@post.harvard.edu.|Mongan Institute for Health Policy, Massachusetts General Hospital, Boston, MA, USA. xabi@post.harvard.edu.
authors.forename: Xabier
authors.initials: X
authors.lastname: García-Albéniz
authors.affiliation: Mongan Institute for Health Policy, Massachusetts General Hospital, Boston, MA, USA.|Department of Health Care Policy, Harvard Medical School, Boston, MA, USA.
authors.forename: John
authors.initials: J
authors.lastname: Hsu
authors.affiliation: Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.|Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
authors.forename: Marc
authors.initials: M
authors.lastname: Lipsitch
authors.affiliation: Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
authors.forename: Roger W
authors.initials: RW
authors.lastname: Logan
authors.affiliation: Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
authors.forename: Sonia
authors.initials: S
authors.lastname: Hernández-Díaz
authors.affiliation: Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.|Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.|Harvard-MIT Division of Health Sciences and Technology, Boston, MA, USA.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Hernán
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D038801:International Classification of Diseases; D008297:Male; D008498:Medical Record Linkage; D006278:Medicare / Q000706:statistics & numerical data*; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D018426:SEER Program; D017678:Sex Distribution; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology
keywords: Colorectal cancer; Infective endocarditis; Medicare; SEER