title: Clinical significance of neonatal menstruation.
abstract: Past studies have clearly shown the existence of a spectrum of endometrial progesterone responses in neonatal endometrium, varying from proliferation to full decidualization with menstrual-like shedding. The bleedings represent, similar to what occurs in adult menstruation, a progesterone withdrawal bleeding. Today, the bleeding is completely neglected and considered an uneventful episode of no clinical significance. Yet clinical studies have linked the risk of bleeding to a series of events indicating fetal distress. The potential link between the progesterone response and major adolescent disorders requires to be investigated by prospective studies.
authors.affiliation: Leuven Institute for Fertility and Embryology, Leuven, Belgium. Electronic address: ivo.brosens@med.kuleuven.be.
authors.forename: Ivo
authors.initials: I
authors.lastname: Brosens
authors.affiliation: Department of Gynaecology, Obstetrics and Urology, Sapienza, University of Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Benagiano
mesh_terms: D004717:Endometrium / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008598:Menstruation / Q000502:physiology*; D011446:Prospective Studies; D014592:Uterine Hemorrhage / Q000503:physiopathology*
keywords: Adolescent endometriosis; Endometrial bleeding; Fetal distress; Neonate; Preeclampsia