title: Elevated total plasma homocysteine levels are associated with type 2 diabetes in women with hypertension.
abstract: OBJECTIVE
  There is only limited available evidence of a relationship between total plasma homocysteine (tHcy) levels and type 2 diabetes in hypertensive subjects.
  
  
  METHODS
  A total of 5,935 Chinese essentially hypertensive subjects were recruited by cluster sampling from 60 communities. The cases had diabetes, whereas the controls did not. Anthropometric indices and biochemical parameters were assessed using standard procedures. A multivariable analysis was performed to analyze the association of tHcy and type 2 diabetes susceptibility in hypertensive subjects.
  
  
  RESULTS
  The 5,241 controls (women/men: 2,716/2,625) and 594 cases (women/men: 291/303) were recruited consecutively. The level of tHcy was dose- dependently associated with type 2 diabetes in the hypertensive women subjects. After controlling for corresponding confounding factors, a significant trend was only noted in the women subjects, with odds ratios per 5 μmol/L tHcy of 1.11 (95% confidence interval (CI), 1.07-1.16) in the crude model, 1.05 (95% CI, 1.01-1.11) in model 1, and 1.07 (95% CI, 1.02-1.13) in model 2. However, no significant result was found for levels of tHcy>or=15 μmol/L vs <15 μmol/L in the men, women and all hypertensive subjects.
  
  
  CONCLUSIONS
  When the level of tHcy was divided into quartiles, tHcy was positively associated with type 2 diabetes in hypertensive women subjects. However, when the level of tHcy was separated into hyperhomocysteinemic (>or=15 μmol/L) and normal (<15 μmol/L), no significant results were observed.
authors.affiliation: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, the People's Republic of China.
authors.forename: Changyi
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Social Medicine, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, the People's Republic of China.
authors.forename: Qunhong
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Preventive Medicine, Medical School of Ningbo University, Ningbo, Zhejiang, the People's Republic of China.
authors.forename: Lina
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Social Medicine, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, the People's Republic of China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Department of Preventive Medicine, Medical School of Ningbo University, Ningbo, Zhejiang, the People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Fan
authors.affiliation: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, the People's Republic of China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Peng
authors.affiliation: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, the People's Republic of China.
authors.forename: Shengyuan
authors.initials: S
authors.lastname: Liu
authors.affiliation: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, the People's Republic of China.
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, the People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, the People's Republic of China.
authors.forename: Sihan
authors.initials: S
authors.lastname: Chen
authors.affiliation: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, the People's Republic of China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Preventive Medicine, Medical School of Ningbo University, Ningbo, Zhejiang, the People's Republic of China.
authors.forename: Shiwei
authors.initials: S
authors.lastname: Duan
authors.affiliation: Department of Preventive Medicine, Medical School of Ningbo University, Ningbo, Zhejiang, the People's Republic of China. Email: hanliyuan@nbu.edu.cn.
authors.forename: Liyuan
authors.initials: L
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D048909:Diabetes Complications / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D006710:Homocysteine