title: Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges.
abstract: OBJECTIVE
  Medication adherence is often suboptimal for adolescents with HIV, and establishing correct weight-based antiretroviral therapy dosing is difficult, contributing to virological failure. This review aimed to determine the proportion of adolescents achieving virological suppression after initiating ART.
  
  
  METHODS
  MEDLINE, EMBASE and Web of Science databases were searched. Studies published between January 2004 and September 2014 including ≥50 adolescents taking ART and reporting on the proportion of virological suppressed participants were included.
  
  
  RESULTS
  From a total of 5316 potentially relevant citations, 20 studies were included. Only eight studies reported the proportion of adolescents that were virologically suppressed at a specified time point. The proportion of adolescents with virological suppression at 12 months ranged from 27 to 89%.
  
  
  CONCLUSIONS
  Adolescent achievement of HIV virological suppression was highly variable. Improved reporting of virological outcomes from a wider range of settings is required to support efforts to improve HIV care and treatment for adolescents.
authors.affiliation: London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: Rashida A
authors.initials: RA
authors.lastname: Ferrand
authors.affiliation: London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: Datonye
authors.initials: D
authors.lastname: Briggs
authors.affiliation: World Health Organization, Geneva, Switzerland.
authors.forename: Jane
authors.initials: J
authors.lastname: Ferguson
authors.affiliation: World Health Organization, Geneva, Switzerland.
authors.forename: Martina
authors.initials: M
authors.lastname: Penazzato
authors.affiliation: World Health Organization, Geneva, Switzerland.
authors.forename: Alice
authors.initials: A
authors.lastname: Armstrong
authors.affiliation: Department of Public Health and Policy, University of Liverpool, Liverpool, UK.|Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: MacPherson
authors.affiliation: London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: David A
authors.initials: DA
authors.lastname: Ross
authors.affiliation: London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: Katharina
authors.initials: K
authors.lastname: Kranzer
mesh_terms: D000293:Adolescent; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D055118:Medication Adherence; D016896:Treatment Outcome; D019562:Viral Load / Q000187:drug effects*
chemical_list: D019380:Anti-HIV Agents
keywords: Adolescentes; Adolescents; HIV; VIH; adolescents; suppression virologique; supresión virológica; virological suppression