title: Initial investigations into the hormonal basis of spermatogenesis.
abstract: MacLeod J, Pazianos A, Ray B. The restoration of human spermatogenesis and of the reproductive tract with urinary gonadotropins following hypophysectomy. Fertil Steril 1966;17(1):7-23. "No precedent was available in the male for the amount of [human menopausal gonadotropin] to be given in order to initiate spermatogenesis, if the latter could be done at all." "In this experiment, the evidence is strongly in favor of FSH activity being exerted first at the level of the spermatogonium, inducing mitosis and proliferation of this cell."
authors.affiliation: Division of Urology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Martin
authors.initials: M
authors.lastname: Kathrins
mesh_terms: D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D006801:Humans; D007016:Hypophysectomy / Q000009:adverse effects*; D007248:Infertility, Male / Q000188:drug therapy*; D008297:Male; D013094:Spermatozoa / Q000187:drug effects*; D014566:Urogenital System / Q000187:drug effects*
chemical_list: D006063:Chorionic Gonadotropin