title: Detection of mcr-1 encoding plasmid-mediated colistin-resistant Escherichia coli isolates from human bloodstream infection and imported chicken meat, Denmark 2015.
abstract: The plasmid-mediated colistin resistance gene, mcr-1, was detected in an Escherichia coli isolate from a Danish patient with bloodstream infection and in five E. coli isolates from imported chicken meat. One isolate from chicken meat belonged to the epidemic spreading sequence type ST131. In addition to IncI2, an incX4 replicon was found to be linked to mcr-1. This report follows a recent detection of mcr-1 in E. coli from animals, food and humans in China.
authors.affiliation: Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.
authors.forename: Henrik
authors.initials: H
authors.lastname: Hasman
authors.forename: Anette M
authors.initials: AM
authors.lastname: Hammerum
authors.forename: Frank
authors.initials: F
authors.lastname: Hansen
authors.forename: Rene S
authors.initials: RS
authors.lastname: Hendriksen
authors.forename: Bente
authors.initials: B
authors.lastname: Olesen
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Agersø
authors.forename: Ea
authors.initials: E
authors.lastname: Zankari
authors.forename: Pimlapas
authors.initials: P
authors.lastname: Leekitcharoenphon
authors.forename: Marc
authors.initials: M
authors.lastname: Stegger
authors.forename: Rolf S
authors.initials: RS
authors.lastname: Kaas
authors.forename: Lina M
authors.initials: LM
authors.lastname: Cavaco
authors.forename: Dennis S
authors.initials: DS
authors.lastname: Hansen
authors.forename: Frank M
authors.initials: FM
authors.lastname: Aarestrup
authors.forename: Robert L
authors.initials: RL
authors.lastname: Skov
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002645:Chickens; D003091:Colistin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000097:blood* / Q000188:drug therapy; D005838:Genotype; D006801:Humans; D008460:Meat / Q000382:microbiology; D010957:Plasmids
chemical_list: D000900:Anti-Bacterial Agents; D003091:Colistin
keywords: Denmark; Escherichia coli; antimicrobial resistance; bacterial infections; clinic; healthcare-associated infections; molecular methods; multidrug resistance; surveillance; typing