title: Facile Construction of pH- and Redox-Responsive Micelles from a Biodegradable Poly(β-hydroxyl amine) for Drug Delivery.
abstract: Here we demonstrate a type of pH and reduction dual-sensitive biodegradable micelles, which were self-assembled by a cationic polymer in an aqueous solution. Due to tumor cells or tissues showing low pH and high reduction concentration, these micelles possessed specific tumor targetability and maximal drug-release controllability inside tumor cells upon changes in physical and chemical environments, but presented good stability at physiological conditions. CCK-8 assay showed that the DOX-loaded micelles had a similar cytotoxicity for MCF-7 tumor cells as free DOX, and blank micelles had a very low cytotoxicity to the cells. Fluorescent microscopy observation revealed that the drug-loaded micelles could be quickly internalized by endosomes to inhibit cancer cell growth. These results indicated these biodegradable micelles, as a novel and effective pH- and redox-responsive nanocarrier, have a potential to improve drug delivery and enhance the antitumor efficacy.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.|Department of Orthopaedics, The 309th Hospital of the PLA , Beijing 100094, China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Li
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Yazhong
authors.initials: Y
authors.lastname: Bu
authors.affiliation: Center of Rehabilitation, Chinese People's Liberation Army General Hospital , Fuxing Road, Beijing, 100853, China.
authors.forename: Lining
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Yanyu
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Zhuang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Decheng
authors.initials: D
authors.lastname: Wu
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001673:Biodegradation, Environmental; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D065546:Drug Liberation / Q000502:physiology*; D004705:Endocytosis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006898:Hydroxylamines / Q000737:chemistry*; D061986:MCF-7 Cells; D008823:Micelles; D009369:Neoplasms / Q000188:drug therapy*; D010084:Oxidation-Reduction
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D006898:Hydroxylamines; D008823:Micelles; D004317:Doxorubicin