title: Genetic variability of DNA repair mechanisms in chemotherapy treatment outcome of gastric cancer patients.
abstract: We investigate whether three common polymorphisms in ERCC1 and ERCC2 are predictor factors for the chemotherapy response, as well as the clinic outcome of patients with gastric cancer. Between May 2011 and May 2013, 263 patients with gastric cancer who were newly diagnosed by histopathology were enrolled in our study. Genotyping of the ERCC1 rs11615 and rs3212986, and ERCC2 rs1799793 polymorphisms were conducted by the polymerase chain reaction-restriction fragment length polymorphism assay. Patients carrying the TT genotype and TT+CT genotype of ERCC1 rs11615 were associated with poorer response to chemotherapy and shorter survival times when compared with the CC genotype. In conclusion, our results suggested that the ERCC1 rs11615 polymorphism in the DNA repair pathways can be used as predictive factors to the clinical outcome of patients with gastric cancer.
authors.affiliation: Department of Gastrointestinal Surgery, Tianjin Nankai Hospital, Tianjin, China.
authors.forename: G
authors.initials: G
authors.lastname: Zhong
authors.affiliation: Department of Abdominal Tumor Surgery, Tianjin Medical University Cancer Institute Hospital, Tianjin, China.
authors.forename: H K
authors.initials: HK
authors.lastname: Li
authors.affiliation: Department of Gastrointestinal Surgery, Tianjin Nankai Hospital, Tianjin, China.
authors.forename: T
authors.initials: T
authors.lastname: Shan
authors.affiliation: Department of Gastrointestinal Surgery, Tianjin Nankai Hospital, Tianjin, China.
authors.forename: N
authors.initials: N
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000483:Alleles; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004260:DNA Repair / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D004720:Endonucleases / Q000235:genetics; D005260:Female; D005472:Fluorouracil; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D002955:Leucovorin; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D016896:Treatment Outcome; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D009944:Organoplatinum Compounds; C071447:ERCC1 protein, human; D004720:Endonucleases; D051759:Xeroderma Pigmentosum Group D Protein; D002955:Leucovorin; D005472:Fluorouracil