title: Operative hysteroscopy for treatment of intrauterine pathologies does not interfere with later endometrial development in patients undergoing in vitro fertilization.
abstract: OBJECTIVE
  Operative hysteroscopy procedure is extensively used for the treatment of intrauterine abnormalities that can potentially cause infertility. To date, there are little data addressing the effect of operative hysteroscopy that applies electrical current for excision and its subsequent effect on endometrial thickness. This study was aimed to assess the effect of thermal resection used in operative hysteroscopy on endometrial thickness and on fertility outcome in women undergoing in vitro fertilization (IVF).
  
  
  METHODS
  A retrospective study conducted at Hadassah-Hebrew University Medical Center, a tertiary referral center. Included were IVF women who underwent an operative hysteroscopy throughout the years 2000-2010 for intrauterine pathologies.
  
  
  RESULTS
  Throughout the years 2000-2010, 41 IVF women who underwent an operative hysteroscopy using electric current between their 82 IVF cycles were studied. The mean age of women at the time of the intervention was 37.1 years (36.7 and 37.5 at the IVF cycles before and after intervention, respectively). The maximal endometrial thickness before operative hysteroscopy was 10.7 mm compared to 9.5 mm after all procedures (P < 0.001). Excluding polypectomy cases (n = 24) the endometrial thickness was 9.9 mm before vs. 9.1 mm after operative hysteroscopy (P < 0.001). The clinical pregnancy rate was 19.5 % before as compared to 24.4 % after operative hysteroscopy (NS). The take home baby rate (THBR), however, was significantly increased following operative hysteroscopy for all indications from 2.4 to 12.2 % (P < 0.05).
  
  
  CONCLUSIONS
  Despite the small change in endometrial thickness, our results indicate that using electric current is safe to treat intrauterine pathologies.
authors.affiliation: Department of Obstetrics and Gynecology, Hadassah Medical Center and Hebrew University-Hadassah Medical School, P.O. Box 12000, 91120, Jerusalem, Israel.
authors.forename: Liron
authors.initials: L
authors.lastname: Kogan
authors.affiliation: Department of Obstetrics and Gynecology, Hadassah Medical Center and Hebrew University-Hadassah Medical School, P.O. Box 12000, 91120, Jerusalem, Israel.
authors.forename: Uri
authors.initials: U
authors.lastname: Dior
authors.affiliation: Department of Obstetrics and Gynecology, Hadassah Medical Center and Hebrew University-Hadassah Medical School, P.O. Box 12000, 91120, Jerusalem, Israel.
authors.forename: Henry H
authors.initials: HH
authors.lastname: Chill
authors.affiliation: Department of Obstetrics and Gynecology, Hadassah Medical Center and Hebrew University-Hadassah Medical School, P.O. Box 12000, 91120, Jerusalem, Israel. giladk84@gmail.com.
authors.forename: Gilad
authors.initials: G
authors.lastname: Karavani
authors.affiliation: Department of Obstetrics and Gynecology, Hadassah Medical Center and Hebrew University-Hadassah Medical School, P.O. Box 12000, 91120, Jerusalem, Israel.
authors.forename: Ariel
authors.initials: A
authors.lastname: Revel
authors.affiliation: Department of Obstetrics and Gynecology, Hadassah Medical Center and Hebrew University-Hadassah Medical School, P.O. Box 12000, 91120, Jerusalem, Israel.
authors.forename: Asher
authors.initials: A
authors.lastname: Shushan
authors.affiliation: Department of Obstetrics and Gynecology, Hadassah Medical Center and Hebrew University-Hadassah Medical School, P.O. Box 12000, 91120, Jerusalem, Israel.
authors.forename: Alex
authors.initials: A
authors.lastname: Simon
mesh_terms: D000328:Adult; D004717:Endometrium / Q000473:pathology*; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro; D006801:Humans; D015907:Hysteroscopy / Q000009:adverse effects*; D007246:Infertility / Q000209:etiology / Q000601:surgery*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D014591:Uterine Diseases / Q000601:surgery*
keywords: Endometrial thickness; IVF; Operative hysteroscopy; THBR