title: Sesquiterpenoids from the roots of Vladimiria muliensis.
abstract: An unusual aromadendrane-type sesquiterpenoid with a rare hemiketal-containing 10/3 ring system, named vladimuliecin C (1), and one new eudesmane-type sesquiterpenoid, named vladimuliecin D (4), together with four known sesquiterpenoids, were isolated from the roots of Vladimiria muliensis. The structures of these compounds were elucidated by analysis of spectroscopic data. The absolute configuration of 1 was assigned by X-ray diffraction analysis. A possible biosynthetic process for the formation of 1 is proposed. Compound 1 showed moderate cytotoxicity against three human tumor cell lines.
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry , College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou , 730000 , China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Chen
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry , College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou , 730000 , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Bai
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry , College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou , 730000 , China.
authors.forename: Fekadu-Roge
authors.initials: FR
authors.lastname: Gobu
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry , College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou , 730000 , China.
authors.forename: Cheng-Hui
authors.initials: CH
authors.lastname: Wu
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry , College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou , 730000 , China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zeng
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry , College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou , 730000 , China.
authors.forename: Meng
authors.initials: M
authors.lastname: Sun
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry , College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou , 730000 , China.
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045789:Sesquiterpenes, Guaiane
chemical_list: D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; D045789:Sesquiterpenes, Guaiane; C519959:aromadendrane; C000607671:vladimuliecin C; C000607672:vladimuliecin D; C015872:eudesmane
keywords: Compositae; Vladimiria muliensis; aromadendrane-type sesquiterpenoid; cytotoxicity; eudesmane-type sesquiterpenoid