title: Prevalence and correlates of DSM-5 eating disorders in patients with bipolar disorder.
abstract: OBJECTIVE
  To determine prevalence rates and clinical correlates of current DSM-5 eating disorders in patients with bipolar disorder (BP).
  
  
  METHODS
  Prevalence rates of current DSM-5- and DSM-IV-defined binge eating disorder (BED), bulimia nervosa (BN), and anorexia nervosa (AN) were assessed with the Eating Disorder Diagnostic Scale (EDDS) in 1092 patients with BP. Psychiatric illness burden was evaluated with five proxy measures of BP illness severity. Medical illness burden was evaluated with the Cumulative Index Rating Scale (CIRS).
  
  
  RESULTS
  Twenty-seven percent of patients had a current DSM-5 eating disorder: 12% had BED, 15% had BN, and 0.2% had AN. Rates of DSM-5-defined BED and BN were higher than clinical diagnosis rates and rates of DSM-IV-defined BED and BN. Compared with BP patients without an eating disorder, BP patients with a DSM-5 eating disorder were younger and more likely to be women; had an earlier age of onset of BP; had higher EDDS composite scores and higher degrees of suicidality, mood instability, and anxiety disorder comorbidity; and had a higher mean BMI, higher rate of obesity, and higher CIRS total scores. In a logistic regression model controlling for previously identified correlates of an eating disorder, younger age, female gender, and higher BMI remained significantly associated with an eating disorder.
  
  
  CONCLUSIONS
  The EDDS has not been validated in BP patients.
  
  
  CONCLUSIONS
  DSM-5-defined BED and BN are common in BP patients, possibly more common than DSM-IV-defined BED and BN, and associated with greater psychiatric and general medical illness burden. Further studies assessing DSM-5 eating disorders in people with BP are greatly needed.
authors.affiliation: Lindner Center of HOPE, 4075 Old Western Row Road, Mason, OH 45040, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: susan.mcelroy@lindnercenter.org.
authors.forename: Susan L
authors.initials: SL
authors.lastname: McElroy
authors.affiliation: Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA; The Emily Program, St. Paul, MN, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Crow
authors.affiliation: Lindner Center of HOPE, 4075 Old Western Row Road, Mason, OH 45040, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Blom
authors.affiliation: Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA; Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Biernacka
authors.affiliation: Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: Stacey J
authors.initials: SJ
authors.lastname: Winham
authors.affiliation: Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Geske
authors.affiliation: Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.
authors.forename: Alfredo B
authors.initials: AB
authors.lastname: Cuellar-Barboza
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: William V
authors.initials: WV
authors.lastname: Bobo
authors.affiliation: Universidad de los Andes, Facultad de Medicina, Departamento de Psiquiatría, Santiago, Chile.
authors.forename: Miguel L
authors.initials: ML
authors.lastname: Prieto
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: Marin
authors.initials: M
authors.lastname: Veldic
authors.affiliation: Lindner Center of HOPE, 4075 Old Western Row Road, Mason, OH 45040, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Mori
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Seymour
authors.affiliation: Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Bond
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Frye
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000856:Anorexia Nervosa / Q000453:epidemiology* / Q000523:psychology; D001008:Anxiety Disorders / Q000453:epidemiology / Q000523:psychology; D056912:Binge-Eating Disorder / Q000453:epidemiology* / Q000523:psychology; D001714:Bipolar Disorder / Q000523:psychology*; D015992:Body Mass Index; D052018:Bulimia Nervosa / Q000453:epidemiology* / Q000523:psychology; D015897:Comorbidity; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000523:psychology; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D013405:Suicide / Q000523:psychology / Q000706:statistics & numerical data
keywords: Binge eating; Bipolar disorder; Bulimia nervosa; DSM-5 eating disorders