title: Epidemiology and treatment of angiolymphoid hyperplasia with eosinophilia (ALHE): A systematic review.
abstract: BACKGROUND
  Current knowledge of angiolymphoid hyperplasia with eosinophilia (ALHE) derives from retrospective reports and case series, leading to a nonevidence-based treatment approach.
  
  
  OBJECTIVE
  We sought to systematically review the literature relating to cutaneous ALHE to estimate its epidemiology and treatment outcomes.
  
  
  METHODS
  A literature search of PubMed, EMBASE, Web of Science, and Google Scholar was conducted. Articles detailing cases of histologically confirmed cutaneous ALHE were included.
  
  
  RESULTS
  In all, 416 studies were included in the review, representing 908 patients. There was no sex predominance among patients with ALHE. Mean age at presentation was 37.6 years. There was a significant association between presence of multiple lesions and pruritus, along with bleeding. Surgical excision was the most commonly reported treatment for ALHE. Treatment failure was lowest for excision and pulsed dye laser. Mean disease-free survival after excision was 4.2 years. There were higher rates of recurrence postexcision with earlier age of onset, longer duration of disease, multiple lesions, bilateral lesions, pruritus, pain, and bleeding.
  
  
  CONCLUSIONS
  Potential for publication bias is a limitation.
  
  
  CONCLUSIONS
  Surgical excision appears to be the most effective treatment for ALHE, albeit suboptimal. Pulsed dye and other lasers may be effective treatment options. More studies are needed to improve the treatment of ALHE.
authors.affiliation: Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, New York, New York.
authors.forename: Brandon L
authors.initials: BL
authors.lastname: Adler
authors.affiliation: Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, New York, New York.
authors.forename: Aimee E
authors.initials: AE
authors.lastname: Krausz
authors.affiliation: D. Samuel Gottesman Library, Albert Einstein College of Medicine, New York, New York.
authors.forename: Aurelia
authors.initials: A
authors.lastname: Minuti
authors.affiliation: Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Silverberg
authors.affiliation: Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, New York, New York. Electronic address: lhadar1@gmail.com.
authors.forename: Hadar
authors.initials: H
authors.lastname: Lev-Tov
mesh_terms: D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000453:epidemiology* / Q000628:therapy*; D006801:Humans
keywords: angiolymphoid hyperplasia with eosinophilia; epidemiology; excision; histiocytoid hemangioma; pseudopyogenic granuloma; surgery