title: Safety of a thickened extensive casein hydrolysate formula.
abstract: OBJECTIVE
  Cow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA.
  
  
  METHODS
  Infants younger than 6 mo old with a positive cow milk challenge test, positive IgE, or skin prick test for cow milk were selected. Weight and length were followed during the 6 mo intervention with the NT-eCHF and T-eCHF.
  
  
  RESULTS
  A challenge was performed in 50/71 infants with suspected CMA and was positive in 34/50. All children with confirmed CMA tolerated the eCHF. The T-eCHF leads to a significant improvement of the stool consistency in the whole population and in the subpopulation of infants with proven CMA. Height and weight evolution was satisfactory throughout the 6 mo study.
  
  
  CONCLUSIONS
  The eCHF fulfills the criteria of a hypoallergenic formula and the NT- and T-eCHF reduced CMA symptoms. Growth was within normal range.
authors.affiliation: UZ Brussel, Department of Pediatrics, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: yvan.vandenplas@uzbrussel.be.
authors.forename: Yvan
authors.initials: Y
authors.lastname: Vandenplas
authors.affiliation: UZ Brussel, Department of Pediatrics, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: De Greef
authors.affiliation: Department of Pediatrics, Hippocration Hospital, Thessaloniki, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Xinias
authors.affiliation: Department of Pediatrics, Hippocration Hospital, Thessaloniki, Greece.
authors.forename: O
authors.initials: O
authors.lastname: Vrani
authors.affiliation: Department of Pediatrics, Hippocration Hospital, Thessaloniki, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Mavroudi
authors.affiliation: Faculty of Medicine, Department of Pediatrics, Kuwait University, Kuwait City, Kuwait.
authors.forename: M
authors.initials: M
authors.lastname: Hammoud
authors.affiliation: Faculty of Medicine, Department of Pediatrics, Kuwait University, Kuwait City, Kuwait.
authors.forename: F
authors.initials: F
authors.lastname: Al Refai
authors.affiliation: Holy Spirit University of Kaslik, Kaslikand UH-NDS, Beyruth, Lebanon.
authors.forename: M C
authors.initials: MC
authors.lastname: Khalife
authors.affiliation: Holy Spirit University of Kaslik, Kaslikand UH-NDS, Beyruth, Lebanon.
authors.forename: A
authors.initials: A
authors.lastname: Sayad
authors.affiliation: Holy Spirit University of Kaslik, Kaslikand UH-NDS, Beyruth, Lebanon.
authors.forename: P
authors.initials: P
authors.lastname: Noun
authors.affiliation: Holy Spirit University of Kaslik, Kaslikand UH-NDS, Beyruth, Lebanon.
authors.forename: A
authors.initials: A
authors.lastname: Farah
authors.affiliation: Tripoli, Lebanon.
authors.forename: G
authors.initials: G
authors.lastname: Makhoul
authors.affiliation: University Children's Hospital, Ljubljana, Slovenia.
authors.forename: R
authors.initials: R
authors.lastname: Orel
authors.affiliation: University of Balamand, Beirut, Lebanon.
authors.forename: M
authors.initials: M
authors.lastname: Sokhn
authors.affiliation: Department of Pediatrics, La Citadelle Regional Hospital, Liège, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: L'Homme
authors.affiliation: Department of Pediatrics, La Citadelle Regional Hospital, Liège, Belgium.
authors.forename: M P
authors.initials: MP
authors.lastname: Mohring
authors.affiliation: Beirut, Lebanon.
authors.forename: B Abou
authors.initials: BA
authors.lastname: Merhi
authors.affiliation: Mount Lebanon Hospital, Beyruth, Lebanon.
authors.forename: J
authors.initials: J
authors.lastname: Boulos
authors.affiliation: Bahman Hospital, Medical Director Dar Hawraa Center, Beyruth, Lebanon.
authors.forename: H
authors.initials: H
authors.lastname: El Masri
authors.affiliation: Department of Pediatrics, Regional Hospital, Namur, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Halut
mesh_terms: D000818:Animals; D001827:Body Height; D001835:Body Weight; D002364:Caseins / Q000008:administration & dosage*; D002657:Child Development; D004040:Dietary Carbohydrates / Q000032:analysis; D004041:Dietary Fats / Q000032:analysis; D004043:Dietary Fiber / Q000032:analysis; D004044:Dietary Proteins / Q000032:analysis; D004311:Double-Blind Method; D002149:Energy Intake; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D041943:Infant Formula / Q000008:administration & dosage*; D057045:Laryngopharyngeal Reflux / Q000517:prevention & control; D008297:Male; D008892:Milk; D016269:Milk Hypersensitivity / Q000517:prevention & control; D011446:Prospective Studies; D011492:Protein Hydrolysates / Q000008:administration & dosage; D014783:Viscosity
chemical_list: D002364:Caseins; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004043:Dietary Fiber; D004044:Dietary Proteins; D011492:Protein Hydrolysates; D007073:Immunoglobulin E; C475729:casein hydrolysate
keywords: (Extensive) hydrolysate; Antiregurgitation formula; Cow's milk allergy; Infant nutrition; Thickened formula