title: [Indication for total knee arthroplasty: evidence mapping].
abstract: BACKGROUND
  Joint replacement surgery is one of the most often performed routine procedures for the treatment of knee osteoarthritis in Germany. Currently, there is no consensus on indication criteria for total knee arthroplasty (TKA).
  
  
  OBJECTIVE
  The topic indication for TKA was processed using six guiding questions concerning: 1) Common practice in determining the indication for TKA; 2) Inclusion criteria in clinical trials; 3) Treatment goals/goal criteria; 4) Predictors for goal attainment; 5) Economic aspects of determining a TKA indication; 6) Guidelines of the "Working Group of Scientific Medical Societies" (AWMF) in other areas.
  
  
  METHODS
  The evidence mapping was conducted by systematically searching Medline via Ovid, the Cochrane Library, through hand searching national guidelines and selected journals as well as the AWMF guideline portal.
  1) In Germany there is currently no consented guideline regarding indications for TKA surgery. 2) Indication criteria for clinical trials are: diagnosed osteoarthritis of the knee, limitations of age and BMI. The most common criteria for exclusion include rheumatoid/inflammatory arthritis, secondary diagnoses and allergies. 3) As yet, no international initiatives have been identified which, by involving all relevant stakeholders, have reached consensus regarding the indication criteria for TKA. 4) A variety of predictors were identified with effects on individual treatment goals acting in different directions. 5) Very few studies were identified concerning economic aspects of determining TKA indication. 6) Comparable AWMF guidelines are currently not available.
  
  
  CONCLUSIONS
  The findings of this study suggest that specific systematic reviews are needed to explore the following questions: What are the treatment goals of a TKA intervention? For whom are these relevant? And how are they measured? Continuous analyses are recommended in the field of predictors for a positive TKA outcome.
authors.affiliation: Zentrum für Evidenzbasierte Gesundheitsversorgung, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Deutschland; UniversitätsCentrums für Orthopädie und Unfallchirurgie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Deutschland.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Haase
authors.affiliation: Zentrum für Evidenzbasierte Gesundheitsversorgung, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Deutschland; UniversitätsCentrums für Orthopädie und Unfallchirurgie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Deutschland.
authors.forename: Toni
authors.initials: T
authors.lastname: Lange
authors.affiliation: UniversitätsCentrums für Orthopädie und Unfallchirurgie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Deutschland.
authors.forename: Jörg
authors.initials: J
authors.lastname: Lützner
authors.affiliation: Zentrum für Evidenzbasierte Gesundheitsversorgung, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Deutschland.
authors.forename: Christian
authors.initials: C
authors.lastname: Kopkow
authors.affiliation: Zentrum für Evidenzbasierte Gesundheitsversorgung, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Deutschland; Qualitäts- und Medizinisches Risikomanagement, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Deutschland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Petzold
authors.affiliation: UniversitätsCentrums für Orthopädie und Unfallchirurgie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Deutschland.
authors.forename: Klaus-Peter
authors.initials: KP
authors.lastname: Günther
authors.affiliation: Zentrum für Evidenzbasierte Gesundheitsversorgung, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Deutschland. Electronic address: Jochen.Schmitt@uniklinikum-dresden.de.
authors.forename: Jochen
authors.initials: J
authors.lastname: Schmitt
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee; D032921:Consensus; D003430:Cross-Sectional Studies; D055317:Evidence-Based Practice; D005260:Female; D005858:Germany; D019983:Guideline Adherence; D006302:Health Services Research / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D000069342:Medical Overuse / Q000706:statistics & numerical data; D008875:Middle Aged; D009313:National Health Programs / Q000706:statistics & numerical data; D020370:Osteoarthritis, Knee / Q000453:epidemiology* / Q000601:surgery*; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data; D012737:Sex Factors; D055815:Young Adult
keywords: Endoprothese; Gonarthrose; Indikation; Knie; Osteoarthritis; TEP; indication; knee; replacement