title: Ocular Applications of Dipyridamole: A Review of Indications and Routes of Administration.
abstract: Dipyridamole was introduced decades ago as a treatment for angina, subsequently found to inhibit platelet aggregation. It is most commonly used, and approved for use in thromboembolism prevention, following surgery. Some of its recognized effects such as adenosine uptake inhibition, elevation of cAMP and cGMP levels, vasodilation, and tissue perfusion are important in various ocular disorders. For this reason, dipyridamole represents an interesting candidate as a therapeutic target for the treatment of eye disorders affecting different ocular structures. The aim of this article is to review the evidence and current understanding of the mechanisms by which dipyridamole exerts its effects on different ocular tissues, discuss the role of dipyridamole in clinical practice, and highlight areas of use and routes of administration.
authors.affiliation: 1 Ocular Research Department, Center for Drug Repurposing, Ariel University , Ariel, Israel .|2 Eye Research Program, MedInsight Research Institute , Hampshire, United Kingdom .
authors.forename: Moshe
authors.initials: M
authors.lastname: Rogosnitzky
authors.affiliation: 1 Ocular Research Department, Center for Drug Repurposing, Ariel University , Ariel, Israel .
authors.forename: Itzhak
authors.initials: I
authors.lastname: Isakov
authors.affiliation: 2 Eye Research Program, MedInsight Research Institute , Hampshire, United Kingdom .
authors.forename: Wjatschesslaw
authors.initials: W
authors.lastname: Wlassoff
authors.affiliation: 2 Eye Research Program, MedInsight Research Institute , Hampshire, United Kingdom .
authors.forename: April
authors.initials: A
authors.lastname: Ingram
authors.affiliation: 1 Ocular Research Department, Center for Drug Repurposing, Ariel University , Ariel, Israel .
authors.forename: Y Robert
authors.initials: YR
authors.lastname: Barishak
mesh_terms: D060433:Administration, Ophthalmic; D004176:Dipyridamole / Q000008:administration & dosage*; D004333:Drug Administration Routes; D005128:Eye Diseases / Q000188:drug therapy*; D006801:Humans; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; D004176:Dipyridamole