title: Randomized study of granulocyte colony stimulating factor for childhood B-cell non-Hodgkin lymphoma: a report from the Japanese pediatric leukemia/lymphoma study group B-NHL03 study.
abstract: The objective of this study was to assess the impact of the primary prophylaxis of granulocyte colony-stimulating factor (G-CSF) in the management of childhood B-cell non-Hodgkin lymphoma (B-NHL). Patients with advanced-stage mature B-NHL were randomized to receive prophylactic G-CSF (G-CSF+) or not receive G-CSF (G-CSF-) based on protocols of the B-NHL03 study. The G-CSF group received 5 μg/kg/d Lenograstim from day 2 after each course of six chemotherapy courses. Fifty-eight patients were assessable, 29 G-CSF + and 29 G-CSF-. G-CSF + patients showed a positive impact on the meantime to neutrophil recovery and hospital stay. On the other hand, they had no impact in the incidences of febrile neutropenia, serious infections, stomatitis and total cost. Our study showed that administration of prophylactic G-CSF through all six chemotherapy courses for childhood B-NHL showed no clinical and economic benefits for the management of childhood B-NHL treatment.
authors.affiliation: a Advanced Medical Research Center , Aichi Medical University , Aichi , Japan ;
authors.forename: Masahito
authors.initials: M
authors.lastname: Tsurusawa
authors.affiliation: b Department of Nutritional Science, Faculty of Psychological and Physical Science , Aichi Gakuin University , Aichi , Japan ;
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: c Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine , University of Tsukuba , Tsukuba , Japan ;
authors.forename: Masahiko
authors.initials: M
authors.lastname: Gosho
authors.affiliation: d Department of Pediatrics , St. Marianna University School of Medicine , Kawasaki , Japan ;
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mori
authors.affiliation: e Department of Pediatrics , Yamagata University Hospital , Yamagata , Japan ;
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Mitsui
authors.affiliation: f Department of Pediatrics , Japanese Red Cross Narita Hospital , Chiba , Japan ;
authors.forename: Shosuke
authors.initials: S
authors.lastname: Sunami
authors.affiliation: g Department of Pediatrics , Sapporo Hokuyu Hospital , Sapporo , Japan ;
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kobayashi
authors.affiliation: h Department of Pediatrics , Kushu Cancer Center , Hakata , Japan ;
authors.forename: Reiji
authors.initials: R
authors.lastname: Fukano
authors.affiliation: i Department of Pediatrics , Saiseikai Yokohama Nanbu Hospital , Yokohama , Japan ;
authors.forename: Fumiko
authors.initials: F
authors.lastname: Tanaka
authors.affiliation: j Department of Pediatrics , Hiroshima Red Cross Hospital , Hiroshima , Japan ;
authors.forename: Naoto
authors.initials: N
authors.lastname: Fujita
authors.affiliation: k Department of Pediatrics , Kurume University Hospital , Kurume , Japan ;
authors.forename: Hiroko
authors.initials: H
authors.lastname: Inada
authors.affiliation: l Pharmaceuticals and Medical Devices Agency , Tokyo , Japan ;
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sekimizu
authors.affiliation: m Department of Hematology/Oncology , Saitama Children's Medical Center , Saitama , Japan ;
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Koh
authors.affiliation: n Department of Hematology-Oncology , Hyogo Children's Hospital , Hyogo , Japan ;
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kosaka
authors.affiliation: o Department of Pediatrics , Mie University Hospital , Mie , Japan ;
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Komada
authors.affiliation: p Clinical Research Center , National Hospital Organization Nagoya Medical Center , Nagoya , Japan ;
authors.forename: Akiko M
authors.initials: AM
authors.lastname: Saito
authors.affiliation: q Department of Pathology , National Center for Child Health and Development , Tokyo , Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nakazawa
authors.affiliation: p Clinical Research Center , National Hospital Organization Nagoya Medical Center , Nagoya , Japan ;
authors.forename: Keizo
authors.initials: K
authors.lastname: Horibe
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D018890:Chemoprevention; D002648:Child; D002675:Child, Preschool; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017048:Health Care Costs; D006760:Hospitalization; D006801:Humans; D007239:Infections / Q000209:etiology; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009503:Neutropenia / Q000209:etiology* / Q000517:prevention & control*; D013921:Thrombocytopenia / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D016179:Granulocyte Colony-Stimulating Factor
keywords: B-NHL; childhood; granulocyte colony stimulating factor