title: Whole-body vibration can attenuate the deterioration of bone mass and trabecular bone microstructure in rats with spinal cord injury.
abstract: METHODS
  Experimental, controlled study.
  
  
  OBJECTIVE
  To examine the effects of whole-body vibration (WBV) on bone mass and trabecular bone microstructure (TBMS) during the early stage in juvenile rats with spinal cord injury (SCI).
  
  
  METHODS
  Studied at the Kio University in Japan.
  
  
  METHODS
  Thirty-four 8-week-old male Wistar rats were divided into 3 groups: the SCI group, the sham-operation group (SHAM) and the SCI+WBV group. WBV started on the 8th day after SCI. After 1 or 2 weeks of WBV treatment, measurements of tissue mineral density, trabecular bone mineral content (BMC) and parameters of TBMS were obtained by scanning the proximal tibias with x-ray micro-computed tomography. Serum levels of osteocalcin (OC) and of tartrate-resistant acid phosphatase 5b (TRACP 5b) were measured with ELISA.
  
  
  RESULTS
  BMC, volume bone mineral density, bone volume (BV), BV fraction (BV/tissue volume) and connectivity density (Conn.D) of TBMS parameters were significantly higher in SCI+WBV rats than in SCI rats after 2-week WBV. The BMC and BV/TV of bone mass index correlated well with Conn.D, suggesting the preservation of Conn.D. induced by WBV. SCI+WBV rats showed a decrease in serum OC after 1-week WBV, but a quick recovery from that after 2-week WBV. There was no difference in serum TRACP 5b among the 3 groups throughout the experimental period.
  
  
  CONCLUSIONS
  WBV treatment could attenuate the bone deterioration that occurs during the early stage in juvenile rats with SCI. In a clinic, this early WBV intervention may be an effective rehabilitation modality for preventing bone fragility in SCI patients.
authors.affiliation: Department of Physical Therapy, Faculty of Health Science, Kio University, Nara, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Minematsu
authors.affiliation: Department of Physical Therapy, Faculty of Health Science, Kio University, Nara, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nishii
authors.affiliation: Department of Physical Therapy, Faculty of Health Science, Kio University, Nara, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Imagita
authors.affiliation: Department of Artificial Organs, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Takeshita
authors.affiliation: Department of Physiology, Nara Medical University, Nara, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sakata
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001835:Body Weight; D015519:Bone Density; D000071556:Cancellous Bone / Q000473:pathology*; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D008297:Male; D009132:Muscles / Q000473:pathology; D015675:Osteocalcin / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013119:Spinal Cord Injuries / Q000097:blood / Q000534:rehabilitation*; D013223:Statistics as Topic; D014732:Vibration / Q000627:therapeutic use*; D055114:X-Ray Microtomography
chemical_list: D015675:Osteocalcin; D000469:Alkaline Phosphatase