title: Mapping homeostatic synaptic plasticity using cable properties of dendrites.
abstract: When chronically silenced, cortical and hippocampal neurons homeostatically upregulate excitatory synaptic function. However, the subcellular position of such changes on the dendritic tree is not clear. We exploited the cable-filtering properties of dendrites to derive a parameter, the dendritic filtering index (DFI), to map the spatial distribution of synaptic currents. Our analysis indicates that young rat cortical neurons globally scale AMPA receptor-mediated currents, while mature hippocampal neurons do not, revealing distinct homeostatic strategies between brain regions and developmental stages. The DFI presents a useful tool for mapping the dendritic origin of synaptic currents and the location of synaptic plasticity changes.
authors.affiliation: Department of Pharmacology & Physiology, Georgetown University Medical Center, Washington, DC, United States; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC, United States; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, United States.
authors.forename: B N
authors.initials: BN
authors.lastname: Queenan
authors.affiliation: Department of Pharmacology & Physiology, Georgetown University Medical Center, Washington, DC, United States; Research Division, Korea Brain Research Institute, Daegu, Republic of Korea.
authors.forename: K J
authors.initials: KJ
authors.lastname: Lee
authors.affiliation: Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, United States.
authors.forename: H
authors.initials: H
authors.lastname: Tan
authors.affiliation: Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, United States.
authors.forename: R L
authors.initials: RL
authors.lastname: Huganir
authors.affiliation: Department of Pharmacology & Physiology, Georgetown University Medical Center, Washington, DC, United States; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC, United States.
authors.forename: S
authors.initials: S
authors.lastname: Vicini
authors.affiliation: Department of Pharmacology & Physiology, Georgetown University Medical Center, Washington, DC, United States; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC, United States. Electronic address: Daniel.Pak@georgetown.edu.
authors.forename: D T S
authors.initials: DT
authors.lastname: Pak
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D003712:Dendrites / Q000187:drug effects / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology*; D007150:Immunohistochemistry; D008810:Mice, Inbred C57BL; D055369:Miniature Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology*; D018408:Patch-Clamp Techniques; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA; D026941:Sodium Channel Blockers / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D018091:Receptors, AMPA; D026941:Sodium Channel Blockers; D013779:Tetrodotoxin
keywords: AMPA receptors; current shape; dendritic filtering index; dendritic origin; homeostatic synaptic plasticity; mEPSC slope