title: Role of Anti-Müllerian Hormone in pathophysiology, diagnosis and treatment of Polycystic Ovary Syndrome: a review.
abstract: Polycystic ovary syndrome (PCOS) is the most common cause of chronic anovulation and hyperandrogenism in young women. Excessive ovarian production of Anti-Müllerian Hormone, secreted by growing follicles in excess, is now considered as an important feature of PCOS. The aim of this review is first to update the current knowledge about the role of AMH in the pathophysiology of PCOS. Then, this review will discuss the improvement that serum AMH assay brings in the diagnosis of PCOS. Last, this review will explain the utility of serum AMH assay in the management of infertility in women with PCOS and its utility as a marker of treatment efficiency on PCOS symptoms. It must be emphasized however that the lack of an international standard for the serum AMH assay, mainly because of technical issues, makes it difficult to define consensual thresholds, and thus impairs the widespread use of this new ovarian marker. Hopefully, this should soon improve.
authors.affiliation: Service de Gynécologie Endocrinienne et de Médecine de la Reproduction, Hôpital Jeanne de Flandre, CHRU, 2 Avenue Eugène Avinée, 59037, Lille, France. agathe.dumont@hotmail.fr.
authors.forename: Agathe
authors.initials: A
authors.lastname: Dumont
authors.affiliation: Service de Gynécologie Endocrinienne et de Médecine de la Reproduction, Hôpital Jeanne de Flandre, CHRU, 2 Avenue Eugène Avinée, 59037, Lille, France. Geoffroy.robin@chru-lille.fr.
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Robin
authors.affiliation: Service de Gynécologie Endocrinienne et de Médecine de la Reproduction, Hôpital Jeanne de Flandre, CHRU, 2 Avenue Eugène Avinée, 59037, Lille, France. Sophie.jonard@chru-lille.fr.
authors.forename: Sophie
authors.initials: S
authors.lastname: Catteau-Jonard
authors.affiliation: Service de Gynécologie Endocrinienne et de Médecine de la Reproduction, Hôpital Jeanne de Flandre, CHRU, 2 Avenue Eugène Avinée, 59037, Lille, France. Didier.dewailly@chru-lille.fr.
authors.forename: Didier
authors.initials: D
authors.lastname: Dewailly
mesh_terms: D054304:Anti-Mullerian Hormone / Q000097:blood* / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D010535:Laparoscopy; D006080:Ovarian Follicle / Q000254:growth & development; D010053:Ovary / Q000503:physiopathology / Q000601:surgery; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000503:physiopathology* / Q000628:therapy; D012016:Reference Values
chemical_list: D015415:Biomarkers; D002996:Clomiphene; D054304:Anti-Mullerian Hormone