title: Jade-1: its structure, regulation and functions in the renal cancer.
abstract: Jade-1 is originally identified by the yeast two-hybrid system as a protein partner of von Hippel-Lindau (pVHL) tumor suppressor, a well-known renal tumor suppressor. In cellular signaling pathways, many upstream Jade-1 regulators, such as pVHL, CK1α, PC1, and NPHP4, can control its activity by stabilization, phosphorylation, and nuclear translocation. Numerous downstream effectors, including β-catenin, AKT, p21, and Bcl-2, are well modulated by Jade-1, which mainly regulates cell proliferation and apoptosis. Jade-1 is also deemed to be a candidate of transcriptional co-activator associated with histone acetyltransferase (HAT) activity. This review focuses on the anticancer role of Jade-1 in clear cell renal carcinoma and the inhibitory effect of Jade-1 on cystic renal diseases. This review aims to provide a basis of disease prevention or therapy.
authors.forename: Y-C
authors.initials: YC
authors.lastname: Zhang
authors.forename: W-Q
authors.initials: WQ
authors.lastname: Du
authors.forename: R-Y
authors.initials: RY
authors.lastname: Zhang
authors.forename: J-N
authors.initials: JN
authors.lastname: Zheng
authors.affiliation: Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou 221002, China 84 West Huai-hai Road, Xuzhou, Jiangsu, P.R. China. dspei@xzmc.edu.cn.
authors.forename: D-S
authors.initials: DS
authors.lastname: Pei
mesh_terms: D000818:Animals; D002292:Carcinoma, Renal Cell / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D052177:Kidney Diseases, Cystic / Q000378:metabolism; D007680:Kidney Neoplasms / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D018398:Homeodomain Proteins; D025521:Tumor Suppressor Proteins