title: Soy Isoflavones and Breast Cancer Cell Lines: Molecular Mechanisms and Future Perspectives.
abstract: The potential benefit of soy isoflavones in breast cancer chemoprevention, as suggested by epidemiological studies, has aroused the interest of numerous scientists for over twenty years. Although intensive work has been done in this field, the preclinical results continue to be controversial and the molecular mechanisms are far from being fully understood. The antiproliferative effect of soy isoflavones has been commonly linked to the estrogen receptor interaction, but there is growing evidence that other pathways are influenced as well. Among these, the regulation of apoptosis, cell proliferation and survival, inhibition of angiogenesis and metastasis or antioxidant properties have been recently explored using various isoflavone doses and various breast cancer cells. In this review, we offer a comprehensive perspective on the molecular mechanisms of isoflavones observed in in vitro studies, emphasizing each time the dose-effect relationship and estrogen receptor status of the cells. Furthermore, we present future research directions in this field which could provide a better understanding of the inner molecular mechanisms of soy isoflavones in breast cancer.
authors.affiliation: Department of Pharmaceutical Analysis, Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, Louis Pasteur Street 6, Cluj-Napoca 400349, Romania. alina.uifalean@umfcluj.ro.|Institute of Biochemistry, Ernst-Moritz-Arndt-University, Felix-Hausdorff Street 4, Greifswald 17487, Germany. alina.uifalean@umfcluj.ro.
authors.forename: Alina
authors.initials: A
authors.lastname: Uifălean
authors.affiliation: Institute of Biochemistry, Ernst-Moritz-Arndt-University, Felix-Hausdorff Street 4, Greifswald 17487, Germany. stefanie.schneider1@uni-greifswald.de.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Schneider
authors.affiliation: Department of Pharmaceutical Biochemistry and Clinical Laboratory, Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, Louis Pasteur Street 6, Cluj-Napoca 400349, Romania. corina.ionescu@umfcluj.ro.
authors.forename: Corina
authors.initials: C
authors.lastname: Ionescu
authors.affiliation: Institute of Biochemistry, Ernst-Moritz-Arndt-University, Felix-Hausdorff Street 4, Greifswald 17487, Germany. lalk@uni-greifswald.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Lalk
authors.affiliation: Department of Pharmaceutical Analysis, Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, Louis Pasteur Street 6, Cluj-Napoca 400349, Romania. iugac@umfcluj.ro.
authors.forename: Cristina Adela
authors.initials: CA
authors.lastname: Iuga
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D007529:Isoflavones / Q000737:chemistry* / Q000494:pharmacology; D061986:MCF-7 Cells; D011960:Receptors, Estrogen / Q000378:metabolism; D013025:Glycine max / Q000737:chemistry*
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D007529:Isoflavones; D011960:Receptors, Estrogen
keywords: breast cancer; estrogen receptor; genistein; isoflavone; molecular mechanism