title: Uridine monophosphate, folic acid and vitamin B12 in patients with symptomatic peripheral entrapment neuropathies.
abstract: BACKGROUND
  Carpal tunnel syndrome is the most common type of peripheral entrapment neuropathy.
  
  
  METHODS
  We performed an exploratory, open-label, multicenter, observational study of 48 patients with peripheral entrapment neuropathy. Patients received a daily capsule of uridine monophosphate, folic acid + vitamin B12 for 2 months and were evaluated using the Pain DETECT questionnaire.
  
  
  RESULTS
  The global score for pain decreased from 17.3 ± 5.9 at baseline to 10.3 ± 6.1 at the final evaluation (p < 0.001). Concomitant analgesic and anti-inflammatory treatment was stopped or the dose reduced in 77.4% of patients.
  
  
  CONCLUSIONS
  Uridine monophosphate + folic acid + vitamin B12 reduced total pain score, intensity and characterization of pain and associated symptoms. These results should be tested in a well-designed, adequately powered randomized controlled trial.
authors.affiliation: Neuromuscular Diseases Unit, Neurology Service, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
authors.forename: Luis
authors.initials: L
authors.lastname: Negrão
authors.affiliation: UCSP Convenção, Odivelas, Lisboa, Portugal.
authors.forename: Paula
authors.initials: P
authors.lastname: Nunes
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002349:Carpal Tunnel Syndrome / Q000150:complications / Q000188:drug therapy; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009408:Nerve Compression Syndromes / Q000150:complications / Q000188:drug therapy*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D013641:Tarsal Tunnel Syndrome / Q000150:complications / Q000188:drug therapy; D016896:Treatment Outcome; D014542:Uridine Monophosphate / Q000008:administration & dosage / Q000627:therapeutic use*; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D005492:Folic Acid; D014542:Uridine Monophosphate; D014805:Vitamin B 12
keywords: Keltican®; Pain DETECT; carpal tunnel syndrome; peripheral entrapment neuropathy