title: Enhanced Ehrlich tumor inhibition using DOX-NP and gold nanoparticles loaded liposomes.
abstract: Treatment with doxorubicin (DOX) is a common treatment for different types of cancer. DOX-NP is one of a well established marketed liposomal formulation for DOX. It has advantages over free DOX in reducing the cardiac toxicity and increasing the efficacy. Gold nanoparticles (GNPs), have been widely used in biomedical applications such as medical imaging and biosensors. Mice bearing Ehrlich tumor were injected with saline, free doxorubicin (DOX) in solution, gold nanoparticles loaded liposomes and commercial liposomal encapsulated doxorubicin (DOX-NP). The results showed that GNPs loaded liposomes could enhance the antitumor activity of commercial liposomal formulation (DOX-NP) and displayed significantly decreased systemic toxicity compared with free DOX and commercial liposomal formulation (DOX-NP) at the equivalent dose. So the injection of GNPs and DOX-NP is expected to increase the cell killing and make it a promising approach to cancer treatment.
authors.affiliation: Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia / Department of Biophysics, Faculty of Science, Cairo University, Giza, Egypt.
authors.forename: Mohsen Mahmoud
authors.initials: MM
authors.lastname: Mady
authors.affiliation: Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Fatima Hasan
authors.initials: FH
authors.lastname: Al-Shaikh
authors.affiliation: Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Faridah Farhan
authors.initials: FF
authors.lastname: Al-Farhan
authors.affiliation: Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia / Department of Biophysics, Faculty of Science, Cairo University, Giza, Egypt.
authors.forename: Amany Abdullah
authors.initials: AA
authors.lastname: Aly
authors.affiliation: King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
authors.forename: Mai Abdullah
authors.initials: MA
authors.lastname: Al-Mohanna
authors.affiliation: Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia / Department of Biophysics, Faculty of Science, Cairo University, Giza, Egypt.
authors.forename: Magdy Mohammed
authors.initials: MM
authors.lastname: Ghannam