title: Recurrent Diffuse Neurofibroma of Nose Associated with Neurofibromatosis Type 1: A Rare Case Report with Review of Literature.
abstract: Diffuse neurofibroma is an unusual variant of neurofibroma with the head and neck being the common sites of involvement. It is benign in nature and spreads superficially and has many ectatic blood vessels. Histologically it is similar to conventional neurofibromas except for a few peculiar distinguishing features. We report a case of a 14-year-old boy who presented with a diffuse recurrent painless swelling over the dorsum of the nose with the clinical stigmata of neurofibromatosis. Microscopy revealed a diagnosis of diffuse neurofibroma with a few foci showing differentiation towards Meissner's type of tactile corpuscles. It is important to recognize this entity as it has a tendency to recur, yet hardly ever become malignant and is almost always associated with neurofibromatosis type 1.
authors.affiliation: Department of Pathology, Saveetha Medical College, Thandalam, Chennai, Tamil Nadu, India.
authors.forename: Vimal
authors.initials: V
authors.lastname: Chander
authors.affiliation: Department of Plastic Surgery, Saveetha Medical College, Thandalam, Chennai, Tamil Nadu, India.
authors.forename: Rvm Surya
authors.initials: RS
authors.lastname: Rao
authors.affiliation: Department of Pathology, Saveetha Medical College, Thandalam, Chennai, Tamil Nadu, India.
authors.forename: Ganthimathy
authors.initials: G
authors.lastname: Sekhar
authors.affiliation: Department of Plastic Surgery, Saveetha Medical College, Thandalam, Chennai, Tamil Nadu, India.
authors.forename: Alagar
authors.initials: A
authors.lastname: Raja
authors.affiliation: Department of Pathology, Saveetha Medical College, Thandalam, Chennai, Tamil Nadu, India.
authors.forename: M
authors.initials: M
authors.lastname: Sridevi
keywords: Diffuse tumor of nose; Meissner's corpuscles; diffuse; neurofibroma; neurofibromatosis type 1