title: Seom guidelines for the treatment of gastric cancer 2015.
abstract: Gastric cancer is the fourth cause of death by cancer in Spain and a significant medical problem. Molecular biology results evidence that gastroesophageal junction tumors and gastric cancer should be considered as two independent entities with a different prognosis and treatment approach. Endoscopic resection in very early tumors is feasible. Neoadjuvant and adjuvant therapy in locally advanced resectable tumor increase overall survival and should be considered standard treatments. In stage IV tumors, platinum-fluoropyrimidine-based schedule, with trastuzumab in HER2-overexpressed tumors, is the first-line treatment. Different therapies in second line have demonstrated in randomized studies their clear benefit in survival improvement.
authors.affiliation: Medical Oncology Department, Hospital de la Santa Creu I Sant Pau, 167, 08025, Barcelona, Spain. mmartinri@santpau.cat.
authors.forename: M
authors.initials: M
authors.lastname: Martin-Richard
authors.affiliation: Medical Oncology Department, Hospital Universitario Clínico San Carlos, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Custodio
authors.affiliation: Medical Oncology Department, Hospital Universitario de Burgos, Burgos, Spain.
authors.forename: C
authors.initials: C
authors.lastname: García-Girón
authors.affiliation: Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Grávalos
authors.affiliation: Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Gomez
authors.affiliation: Medical Oncology Department, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Jimenez-Fonseca
authors.affiliation: Medical Oncology Department, Hospital Universitari Germans Trias I Pujol de Badalona, Barcelona, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Manzano
authors.affiliation: Medical Oncology Department, Hospital de Sabadell-Consorcio Sanitario Parc Taulì, Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Pericay
authors.affiliation: Medical Oncology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Rivera
authors.affiliation: Medical Oncology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Carrato
mesh_terms: D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D019468:Disease Management; D055088:Early Detection of Cancer; D006801:Humans; D008495:Medical Oncology; D009367:Neoplasm Staging; D017410:Practice Guidelines as Topic / Q000592:standards*; D011379:Prognosis; D012955:Societies, Medical; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000628:therapy*
keywords: Cardia; Clinical guidelines; Diagnosis; Gastric adenocarcinoma; Treatment