title: New Insights into Peptide-Silver Nanoparticle Interaction: Deciphering the Role of Cysteine and Lysine in the Peptide Sequence.
abstract: We studied the interaction of four new pentapeptides with spherical silver nanoparticles. Our findings indicate that the combination of the thiol in Cys and amines in Lys/Arg residues is critical to providing stable protection for the silver surface. Molecular simulation reveals the atomic scale interactions that underlie the observed stabilizing effect of these peptides, while yielding qualitative agreement with experiment for ranking the affinity of the four pentapeptides for the silver surface.
authors.affiliation: Institute of Computational Comparative Medicine, Nanotechnology Innovation Center of Kansas State, and Department of Anatomy and Physiology, Kansas State University , Manhattan, Kansas 66506-5802, United States.
authors.forename: Horacio
authors.initials: H
authors.lastname: Poblete
authors.affiliation: Bio-nanomaterials Chemistry and Engineering Laboratory, Cardiac Surgery Research, University of Ottawa Heart Institute , Ottawa, ON K1Y 4W7, Canada.
authors.forename: Anirudh
authors.initials: A
authors.lastname: Agarwal
authors.affiliation: Department of Chemistry, University of Victoria , Victoria, BC V8W 3V6, Canada.
authors.forename: Suma S
authors.initials: SS
authors.lastname: Thomas
authors.affiliation: Department of Chemistry, University of Victoria , Victoria, BC V8W 3V6, Canada.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Bohne
authors.affiliation: Department of Physics, Chemistry and Biology, Linköping University , SE 581 83 Linköping, Sweden.
authors.forename: Ranjithkumar
authors.initials: R
authors.lastname: Ravichandran
authors.affiliation: Department of Physics, Chemistry and Biology, Linköping University , SE 581 83 Linköping, Sweden.
authors.forename: Jaywant
authors.initials: J
authors.lastname: Phopase
authors.affiliation: Institute of Computational Comparative Medicine, Nanotechnology Innovation Center of Kansas State, and Department of Anatomy and Physiology, Kansas State University , Manhattan, Kansas 66506-5802, United States.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Comer
authors.affiliation: Bio-nanomaterials Chemistry and Engineering Laboratory, Cardiac Surgery Research, University of Ottawa Heart Institute , Ottawa, ON K1Y 4W7, Canada.|Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa , Ottawa, ON K1Y 4W7, Canada.
authors.forename: Emilio I
authors.initials: EI
authors.lastname: Alarcon
mesh_terms: D003545:Cysteine / Q000737:chemistry*; D008239:Lysine / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
chemical_list: D010455:Peptides; D012834:Silver; D008239:Lysine; D003545:Cysteine