title: Expression of FABP4, adipsin and adiponectin in Paneth cells is modulated by gut Lactobacillus.
abstract: We here found that intestinal epithelial Paneth cells secrete FABP4, adipsin and adiponectin in both mice and human. Deletion of Paneth cell results in the decrease of FABP4, adipsin and adiponectin not only in intestinal crypt cells but also in sera, suggesting that they may influence the state of the whole body. We also demonstrate that expression of FABP4, adipsin and adiponectin may be modulated by specific gut microbiota. In germ-free (GF) mice, the expression of FABP4, adipsin and adiponectin were lower or difficult to be detected. Feces transplantation promoted the expression of FABP4, adipsin and adiponectin in gut epithelial Paneth cells. We have found that Lactobacillus NK6 colony, which has the highest similarity with Lactobacillus taiwanensis strain BCRC 17755, may induce the expression of FABP4, adipsin and adiponectin through TRAF2 and TRAF6 ubiquitination mediated NF-κB signaling. Taken together, our findings set up a novel mechanism for FABP4, adipsin and adiponectin through gut microbiota mediating expression in gut Paneth cells.
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Tianjin, P. R. China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Su
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Tianjin, P. R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Tianjin, P. R. China.
authors.forename: Yugang
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Tianjin, P. R. China.
authors.forename: Huan
authors.initials: H
authors.lastname: Yun
authors.affiliation: The Fourth Military Medical University, Chongqing, P. R. China.
authors.forename: Benhua
authors.initials: B
authors.lastname: Zeng
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Tianjin, P. R. China.
authors.forename: Enlin
authors.initials: E
authors.lastname: Wang
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Tianjin, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Tianjin, P. R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Tianjin, P. R. China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Tianjin, P. R. China.
authors.forename: Yongzhe
authors.initials: Y
authors.lastname: Che
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, Tianjin, P. R. China.
authors.forename: Zhiqian
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Immunology, Nankai University School of Medicine, Tianjin, P. R. China.|State Key Laboratory of Medicinal Chemical Biology, Tianjin, P. R. China.|Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin, P. R. China.
authors.forename: Rongcun
authors.initials: R
authors.lastname: Yang
mesh_terms: D052242:Adiponectin / Q000096:biosynthesis* / Q000235:genetics; D000818:Animals; D011416:Complement Factor D / Q000096:biosynthesis* / Q000235:genetics; D050556:Fatty Acid-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D005243:Feces; D000069196:Gastrointestinal Microbiome / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D007778:Lactobacillus / Q000378:metabolism*; D051379:Mice; D016328:NF-kappa B / Q000096:biosynthesis; D019879:Paneth Cells / Q000378:metabolism / Q000473:pathology; D047992:TNF Receptor-Associated Factor 2 / Q000235:genetics; D048029:TNF Receptor-Associated Factor 6 / Q000235:genetics
chemical_list: D052242:Adiponectin; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D016328:NF-kappa B; D047992:TNF Receptor-Associated Factor 2; D048029:TNF Receptor-Associated Factor 6; D011416:Complement Factor D