title: Comparison of clinical outcomes according to presentation of angina pectoris versus acute myocardial infarction in patients who underwent a percutaneous coronary intervention with a drug-eluting stent.
abstract: BACKGROUND
  Although randomized clinical trials are valuable tools to compare treatment effects, the results of randomized clinical trials cannot usually be extrapolated to the real-world setting because of selected patient subsets. To categorize the risk of future cardiovascular events in drug-eluting stent (DES)-treated patients, we analyzed demographic, clinical, and procedural data in all-comers who underwent a percutaneous coronary intervention (PCI).
  
  
  METHODS
  Patients who underwent PCI using DES from January 2004 were prospectively enrolled in the Catholic University of Korea-PCI registry and were followed up for a median of 2 years. We analyzed the risk of clinical outcomes in the all-patient cohort and in subsets of patients with angina and acute myocardial infarction (AMI).
  
  
  RESULTS
  The patients were categorized into two groups: those with angina (angina group, n=6183, 67.7%) and those with AMI (AMI group, n=2944, 32.3%). The AMI group had greater occurrence of major adverse cardiac events (MACE) during long-term follow-up than the angina group (23.8 vs. 20.1%, P<0.001). However, in the landmark analysis of data beyond 1 year, there was no significant difference in the occurrence of MACE between the two groups (P=0.44). In multivariable modeling, age, renal function, left ventricular ejection fraction, and multivessel disease were associated significantly with increasing MACE in the study population, angina or AMI groups.
  
  
  CONCLUSIONS
  We found that higher MACE in patients with AMI during long-term follow-up after PCI was mainly because of higher mortality in the first year. Some demographic, clinical, and angiographic factors still significantly influence the long-term occurrence of MACE in the era of DES.
authors.affiliation: aCardiovascular Center and Cardiology Division, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon bCardiovascular Center and Cardiology Division, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu cCardiovascular Center and Cardiology Division, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea dCardiovascular Center and Cardiology Division, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea eCardiovascular Center and Cardiology Division, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul fCardiovascular Center and Cardiology Division, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon gCardiovascular Center and Cardiology Division, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon hCardiovascular Center and Cardiology Division, St Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.
authors.forename: Suk-Min
authors.initials: SM
authors.lastname: Seo
authors.forename: Tae-Hoon
authors.initials: TH
authors.lastname: Kim
authors.forename: Yoon-Seok
authors.initials: YS
authors.lastname: Koh
authors.forename: Sung-Ho
authors.initials: SH
authors.lastname: Her
authors.forename: Dong Il
authors.initials: DI
authors.lastname: Shin
authors.forename: Hun-Jun
authors.initials: HJ
authors.lastname: Park
authors.forename: Pum-Joon
authors.initials: PJ
authors.lastname: Kim
authors.forename: Chul Soo
authors.initials: CS
authors.lastname: Park
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Dong-Bin
authors.initials: DB
authors.lastname: Kim
authors.forename: Hee-Yeol
authors.initials: HY
authors.lastname: Kim
authors.forename: Kiyuk
authors.initials: K
authors.lastname: Chang
authors.forename: Ki-Dong
authors.initials: KD
authors.lastname: Yoo
authors.forename: Doo Soo
authors.initials: DS
authors.lastname: Jeon
authors.forename: Wook-Sung
authors.initials: WS
authors.lastname: Chung
authors.forename: Ki-Bae
authors.initials: KB
authors.lastname: Seung
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000601:surgery; D060050:Angina, Stable / Q000601:surgery*; D000789:Angina, Unstable / Q000601:surgery*; D003324:Coronary Artery Disease / Q000601:surgery*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000601:surgery*; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies; D012042:Registries; D016896:Treatment Outcome