title: Asymmetric Direct 1,2-Addition of Aryl Grignard Reagents to Aryl Alkyl Ketones.
abstract: The enantioselective addition of Grignard reagents to ketones was promoted by a BINOL derivative bearing alkyl chains at the 3,3'-positions. This is the first asymmetric direct aryl Grignard addition to ketones reported to date. A variety of tertiary diaryl alcohols could be obtained in high yields and enantioselectivities without using any other metal source.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kumamoto University , 5-1, Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Osakama
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kumamoto University , 5-1, Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakajima
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry; D007202:Indicators and Reagents; D007659:Ketones / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; C406944:BINOL, naphthol; D007202:Indicators and Reagents; D007659:Ketones; D009284:Naphthols; D009942:Organometallic Compounds; D008274:Magnesium