title: Effect of Film Dressing on Acute Radiation Dermatitis Secondary to Proton Beam Therapy.
abstract: OBJECTIVE
  Acute radiation dermatitis (ARD) is one of the most common adverse events of proton beam therapy (PBT), and there is currently no effective method to manage ARD. The purpose of this study was to examine the prophylactic effect of a film dressing using Airwall on PBT-induced ARD compared with standard skin managements.
  
  
  METHODS
  A total of 271 patients with prostate cancer who were scheduled for PBT at our center were divided into 2 groups based on their own requests: 145 patients (53%) chose Airwall (group A) and 126 patients (47%) received standard treatments (group B). We evaluated irradiated skin every other day during PBT and followed up once a week for a month after completion of PBT.
  
  
  RESULTS
  Grade 0, 1, 2, and 3 dermatitis were seen in 2, 122, 21, and 0 and 0, 65, 57, and 4 patients in groups A and B, respectively (P<.001). Numbers of days to grades 1 and 2 ARD development were 34.9 ± 14.3 and 54.7 ± 10.3 and 31.8 ± 11.3 and 54.4 ± 11.6 in groups A and B, respectively. There were no significant differences between the 2 groups. Eighteen patients (12%) in group A who experienced problems in the region covered with Airwall switched to standard skin care after peeling the film off.
  
  
  CONCLUSIONS
  Film dressing using Airwall reduced the severity of ARD without delaying the response time of the skin to proton beam irradiation compared with standard skin management. Hence, film dressing is considered a promising measure for preventing ARD secondary to PBT.
authors.affiliation: Medipolis Proton Therapy and Research Center, Ibusuki, Japan; Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. Electronic address: arimura-takeshi@medipolis.org.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Arimura
authors.affiliation: Medipolis Proton Therapy and Research Center, Ibusuki, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ogino
authors.affiliation: Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiura
authors.affiliation: Medipolis Proton Therapy and Research Center, Ibusuki, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Toi
authors.affiliation: Medipolis Proton Therapy and Research Center, Ibusuki, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Kawabata
authors.affiliation: Medipolis Proton Therapy and Research Center, Ibusuki, Japan.
authors.forename: Ikuko
authors.initials: I
authors.lastname: Chuman
authors.affiliation: Medipolis Proton Therapy and Research Center, Ibusuki, Japan.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Wada
authors.affiliation: Medipolis Proton Therapy and Research Center, Ibusuki, Japan.
authors.forename: Naoaki
authors.initials: N
authors.lastname: Kondo
authors.affiliation: Medipolis Proton Therapy and Research Center, Ibusuki, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nagayama
authors.affiliation: Medipolis Proton Therapy and Research Center, Ibusuki, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hishikawa
mesh_terms: D000208:Acute Disease; D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D001458:Bandages / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D061766:Proton Therapy / Q000009:adverse effects* / Q000379:methods; D011855:Radiodermatitis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D053832:Surgical Tape / Q000009:adverse effects