title: Serial Assessment of Therapeutic Response to a New Radiosensitization Treatment, Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, Type II (KORTUC II), in Patients with Stage I/II Breast Cancer Using Breast Contrast-Enhanced Magnetic Resonance Imaging.
abstract: BACKGROUND
  We have developed a new radiosensitization treatment called Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, Type II (KORTUC II). Using KORTUC II, we performed breast-conserving treatment (BCT) without any surgical procedure for elderly patients with breast cancer in stages I/II or patients refusing surgery. Since surgery was not performed, histological confirmation of the primary tumor region following KORTUC II treatment was not possible. Therefore, to precisely evaluate the response to this new therapy, a detailed diagnostic procedure is needed. The goal of this study was to evaluate the therapeutic response to KORTUC II treatment in patients with stage I/II breast cancer using annual breast contrast-enhanced (CE) magnetic resonance imaging (MRI).
  
  
  METHODS
  Twenty-one patients with stage I/II breast cancer who were elderly and/or refused surgery were enrolled in this study. All patients underwent MRI prior to and at 3 to 6 months after KORTUC II, and then approximately biannually thereafter. Findings from MRI were compared with those from other diagnostic modalities performed during the same time period.
  
  
  RESULTS
  KORTUC II was well tolerated, with minimal adverse effects. All of 21 patients showed a clinically complete response (cCR) on CE MRI. The mean period taken to confirm cCR on the breast CE MRI was approximately 14 months. The mean follow-up period for the patients was 61.9 months at the end of October 2014.
  
  
  CONCLUSIONS
  The therapeutic effect of BCT using KORTUC II without surgery could be evaluated by biannual CE MRI evaluations. Approximately 14 months were required to achieve cCR in response to this therapy.
authors.affiliation: Department of Diagnostic Radiology &amp; Radiation Oncology, Medical School, Kochi University, Nankoku, Kochi 783-8505, Japan. jm-yaogawa@kochi-u.ac.jp.
authors.forename: Shin
authors.initials: S
authors.lastname: Yaogawa
authors.affiliation: Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Hyogo 675-8555, Japan. ogaway@kochi-u.ac.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ogawa
authors.affiliation: Department of Diagnostic Radiology &amp; Radiation Oncology, Medical School, Kochi University, Nankoku, Kochi 783-8505, Japan. jm-tokuhiros@kochi-u.ac.jp.
authors.forename: Shiho
authors.initials: S
authors.lastname: Morita-Tokuhiro
authors.affiliation: Department of Diagnostic Radiology &amp; Radiation Oncology, Medical School, Kochi University, Nankoku, Kochi 783-8505, Japan. jm-tsuzukia@kochi-u.ac.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Tsuzuki
authors.affiliation: Department of Diagnostic Radiology &amp; Radiation Oncology, Medical School, Kochi University, Nankoku, Kochi 783-8505, Japan. jm-akima.r@kochi-u.ac.jp.
authors.forename: Ryo
authors.initials: R
authors.lastname: Akima
authors.affiliation: Division of Radiology, Medical School Hospital, Kochi University, Nankoku, Kochi 783-8505, Japan. jm-itohk@kochi-u.ac.jp.
authors.forename: Kenji
authors.initials: K
authors.lastname: Itoh
authors.affiliation: Division of Radiology, Medical School Hospital, Kochi University, Nankoku, Kochi 783-8505, Japan. jm-moriok@kochi-u.ac.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Morio
authors.affiliation: Division of Radiology, Medical School Hospital, Kochi University, Nankoku, Kochi 783-8505, Japan. jm-yasunami@kochi-u.ac.jp.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yasunami
authors.affiliation: Department of Pharmacy, Medical School Hospital, Kochi University, Nankoku, Kochi 783-8505, Japan. jm-ma_ono@kochi-u.ac.jp.
authors.forename: Masahide
authors.initials: M
authors.lastname: Onogawa
authors.affiliation: Department of Diagnostic Radiology &amp; Radiation Oncology, Medical School, Kochi University, Nankoku, Kochi 783-8505, Japan. kariyas@kochi-u.ac.jp.
authors.forename: Shinji
authors.initials: S
authors.lastname: Kariya
authors.affiliation: Department of Diagnostic Radiology &amp; Radiation Oncology, Medical School, Kochi University, Nankoku, Kochi 783-8505, Japan. mnogami@kochi-u.ac.jp.
authors.forename: Munenobu
authors.initials: M
authors.lastname: Nogami
authors.affiliation: Department of Diagnostic Radiology &amp; Radiation Oncology, Medical School, Kochi University, Nankoku, Kochi 783-8505, Japan. nishiokaa@kochi-u.ac.jp.
authors.forename: Akihito
authors.initials: A
authors.lastname: Nishioka
authors.affiliation: Department of Pharmacy, Medical School Hospital, Kochi University, Nankoku, Kochi 783-8505, Japan. miyamus@kochi-u.ac.jp.
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Miyamura
keywords: KORTUC; MRI; breast cancer; hydrogen peroxide; radiosensitizer; sodium hyaluronate