title: Front-Line Memory T Cells Think Outside the T-box… Mostly.
abstract: Tissue-resident memory T (Trm) cells patrol barrier tissues. In this issue of Immunity, Carbone and colleagues show that downregulation of T-box proteins Eomesodermin and T-bet is critical for their differentiation, but residual levels of T-bet are important for long-term Trm survival and function.
authors.affiliation: Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: christopher.snyder@jefferson.edu.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Snyder
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D007156:Immunologic Memory / Q000276:immunology*; D019409:Interleukin-15 / Q000276:immunology*; D020825:T-Box Domain Proteins / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000276:immunology*
chemical_list: D019409:Interleukin-15; D020825:T-Box Domain Proteins; D016212:Transforming Growth Factor beta