title: [Hyperammonemic encephalopathy as the presenting feature of a relapsing multiple myeloma].
abstract: BACKGROUND
  Hyperammonemia attributed to multiple myeloma has been rarely reported.
  
  
  METHODS
  We report a 63-year-old man who was admitted to an intensive care unit for confusion and altered mental status progressing to coma that was related to a relapsing multiple myeloma. Chemotherapy allowed the reduction of serum ammonia and the return to a normal state of consciousness.
  
  
  CONCLUSIONS
  Hyperammonemic encephalopathy is a rare complication of multiple myeloma and is associated with high in-patient mortality. To our knowledge, this is the first case of hyperammonemic encephalopathy due to a relapsing myeloma diagnosed and treated in intensive care unit.
authors.affiliation: Service de réanimation médicale, hôpital Saint-André, CHU de Bordeaux, 1, rue Jean-Burguet, 33000 Bordeaux, France. Electronic address: nahema.issa@chu-bordeaux.fr.
authors.forename: N
authors.initials: N
authors.lastname: Issa
authors.affiliation: Service de réanimation médicale, hôpital Saint-André, CHU de Bordeaux, 1, rue Jean-Burguet, 33000 Bordeaux, France.
authors.forename: B
authors.initials: B
authors.lastname: Blondeau
authors.affiliation: Service d'hématologie clinique, hôpital Haut Lévêque, avenue Magellan, 33600 Pessac, France.
authors.forename: S
authors.initials: S
authors.lastname: Dimicoli-Salazar
authors.affiliation: Service d'hématologie clinique, hôpital Haut Lévêque, avenue Magellan, 33600 Pessac, France.
authors.forename: G
authors.initials: G
authors.lastname: Marit
authors.affiliation: Service de médecine interne et maladies infectieuses, hôpital Saint-André, CHU de Bordeaux, 1, rue Jean-Burguet, 33000 Bordeaux, France.
authors.forename: P
authors.initials: P
authors.lastname: Morlat
authors.affiliation: Service de réanimation médicale, hôpital Saint-André, CHU de Bordeaux, 1, rue Jean-Burguet, 33000 Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Camou
mesh_terms: D001927:Brain Diseases / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D022124:Hyperammonemia / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis*; D009364:Neoplasm Recurrence, Local
keywords: Ammonia; Ammoniémie; Encéphalopathie hyperammoniémique; Hyperammonemic encephalopathy; Multiple myeloma; Myélome