title: Impaired brain StAR and HSP70 gene expression in zebrafish exposed to Methyl-Parathion based insecticide.
abstract: Fish production ponds and natural water body areas located in close proximity to agricultural fields receive water with variable amounts of agrochemicals, and consequently, compounds that produce adverse effects may reach nontarget organisms. The aim of this study was to investigate whether waterborne methyl-parathion-based insecticide (MPBI) affected gene expression patterns of brain glucocorticoid receptor (GR), steroidogenic acute regulatory protein (StAR), and heat shock protein 70 (hsp70) in adult zebrafish (Danio rerio) exposed to this chemical for 96 h. Treated fish exposed to MPBI-contaminated water showed an inhibition of brain StAR and hsp70 gene expression. Data demonstrated that MPBI produced a decrease brain StAR and hsp70 gene expression.
authors.affiliation: a Programa de Pós-Graduação em Farmacologia , Universidade Federal de Santa Maria (UFSM) , Santa Maria , Rio Grande do Sul , Brazil.
authors.forename: João Gabriel Santos
authors.initials: JG
authors.lastname: da Rosa
authors.affiliation: a Programa de Pós-Graduação em Farmacologia , Universidade Federal de Santa Maria (UFSM) , Santa Maria , Rio Grande do Sul , Brazil.
authors.forename: Gessi
authors.initials: G
authors.lastname: Koakoski
authors.affiliation: b Programa de Pós-Graduação em Farmacologia e Terapêutica, ICBS , Universidade Federal do Rio Grande do Sul , Porto Alegre , Rio Grande do Sul , Brazil.
authors.forename: Angelo L
authors.initials: AL
authors.lastname: Piato
authors.affiliation: c Programa de Pós-Graduação em Biologia Celular e Molecular , Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul , Porto Alegre , Rio Grande do Sul , Brazil.
authors.forename: Maurício Reis
authors.initials: MR
authors.lastname: Bogo
authors.affiliation: c Programa de Pós-Graduação em Biologia Celular e Molecular , Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul , Porto Alegre , Rio Grande do Sul , Brazil.
authors.forename: Carla Denise
authors.initials: CD
authors.lastname: Bonan
authors.affiliation: a Programa de Pós-Graduação em Farmacologia , Universidade Federal de Santa Maria (UFSM) , Santa Maria , Rio Grande do Sul , Brazil.|d Universidade de Passo Fundo (UPF), Campus Universitário do Bairro São José , Passo Fundo , Rio Grande do Sul , Brazil.|e Programa de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo (UPF) , Campus Universitário do Bairro São José , Passo Fundo , Rio Grande do Sul , Brazil.
authors.forename: Leonardo José Gil
authors.initials: LJ
authors.lastname: Barcellos
mesh_terms: D016573:Agrochemicals / Q000633:toxicity; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D015870:Gene Expression / Q000187:drug effects; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D008743:Methyl Parathion / Q000633:toxicity*; D010750:Phosphoproteins / Q000096:biosynthesis*; D011965:Receptors, Glucocorticoid / Q000096:biosynthesis / Q000187:drug effects; D014874:Water Pollutants, Chemical / Q000633:toxicity; D015027:Zebrafish; D000098682:Steroidogenic Acute Regulatory Protein
chemical_list: D016573:Agrochemicals; D018840:HSP70 Heat-Shock Proteins; D007306:Insecticides; D010750:Phosphoproteins; D011965:Receptors, Glucocorticoid; D014874:Water Pollutants, Chemical; D000098682:Steroidogenic Acute Regulatory Protein; D008743:Methyl Parathion