title: Skeletal muscle regeneration and impact of aging and nutrition.
abstract: After skeletal muscle injury a regeneration process takes place to repair muscle. Skeletal muscle recovery is a highly coordinated process involving cross-talk between immune and muscle cells. It is well known that the physiological activities of both immune cells and muscle stem cells decline with advancing age, thereby blunting the capacity of skeletal muscle to regenerate. The age-related reduction in muscle repair efficiency contributes to the development of sarcopenia, one of the most important factors of disability in elderly people. Preserving muscle regeneration capacity may slow the development of this syndrome. In this context, nutrition has drawn much attention: studies have demonstrated that nutrients such as amino acids, n-3 polyunsaturated fatty acids, polyphenols and vitamin D can improve skeletal muscle regeneration by targeting key functions of immune cells, muscle cells or both. Here we review the process of skeletal muscle regeneration with a special focus on the cross-talk between immune and muscle cells. We address the effect of aging on immune and skeletal muscle cells involved in muscle regeneration. Finally, the mechanisms of nutrient action on muscle regeneration are described, showing that quality of nutrition may help to preserve the capacity for skeletal muscle regeneration with age.
authors.affiliation: Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, Equipe NuTriM, CRNH Auvergne; INRA, UMR 1019, UNH, CRNH Auvergne, 63000 Clermont-Ferrand, France; INRA, UMR1019, UNH, CRNH Auvergne, 63000 Clermont-Ferrand, France.
authors.forename: Carla
authors.initials: C
authors.lastname: Domingues-Faria
authors.affiliation: Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, Equipe ECREIN, CLARA, CRNH Auvergne; INRA, UMR 1019, UNH, CRNH Auvergne, 63000 Clermont-Ferrand, France; Centre Jean Perrin, Unité de Nutrition, 63000 Clermont-Ferrand, France.
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Vasson
authors.affiliation: Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, Equipe ECREIN, CLARA, CRNH Auvergne; INRA, UMR 1019, UNH, CRNH Auvergne, 63000 Clermont-Ferrand, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Goncalves-Mendes
authors.affiliation: Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, Equipe NuTriM, CRNH Auvergne; INRA, UMR 1019, UNH, CRNH Auvergne, 63000 Clermont-Ferrand, France; CHU Clermont-Ferrand, Service de Nutrition Clinique, 63003 Clermont-Ferrand, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Boirie
authors.affiliation: Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, Equipe NuTriM, CRNH Auvergne; INRA, UMR 1019, UNH, CRNH Auvergne, 63000 Clermont-Ferrand, France; INRA, UMR1019, UNH, CRNH Auvergne, 63000 Clermont-Ferrand, France. Electronic address: swalrand@clermont.inra.fr.
authors.forename: Stephane
authors.initials: S
authors.lastname: Walrand
mesh_terms: D000375:Aging / Q000276:immunology / Q000502:physiology; D006801:Humans; D000068884:Immunosenescence / Q000502:physiology*; D018485:Muscle Fibers, Skeletal / Q000502:physiology*; D009752:Nutritional Status; D012038:Regeneration / Q000276:immunology / Q000502:physiology; D055948:Sarcopenia / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control
keywords: Aging; Immunity; Muscle; Nutrition; Regeneration