title: Astrocytes Underlie Neuroinflammatory Memory Impairment.
abstract: Neuroinflammation is being increasingly recognized as a potential mediator of cognitive impairments in various neurological conditions. Habbas et al. demonstrate that the pro-inflammatory cytokine tumor necrosis factor alpha signals through astrocytes to alter synaptic transmission and impair cognition in a mouse model of multiple sclerosis.
authors.affiliation: Neuroscience Graduate Program and Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Osso
authors.affiliation: Neuroscience Graduate Program and Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: jonah.chan@ucsf.edu.
authors.forename: Jonah R
authors.initials: JR
authors.lastname: Chan
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D018891:Dentate Gyrus / Q000378:metabolism*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000503:physiopathology*; D006801:Humans; D008568:Memory; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D014409:Tumor Necrosis Factor-alpha