title: [Effect of Negative Emotions on Serum Levels of Adrenocorticotropic Hormones and Neuropeptide Y in Hepatitis B Liver Cirrhosis Patients].
abstract: OBJECTIVE
  To explore the effect of negative emotions on serum levels of adrenocorticotropic hormone (ACTH) and neuropeptide Y (NYP) in hepatitis B liver cirrhosis (HBLC) patients.
  
  
  METHODS
  Totally 617 HBLC patients were assigned to the negative emotion group (415 cases) and the non-negative emotion group (202 cases) judged by negative emotions. Case numbers of various grading Child-Pugh were recorded in the two groups. Their liver functions were compared between the two groups. Serum levels of ACTH and NPY were detected using double antibody sandwich enzyme-linked immunosorbent assay (ELISA) in the two groups.
  
  
  RESULTS
  There was no statistical difference in Child-Pugh grading between the two groups (χ2 = 0.65, P = 0.72). Compared with the non-negative emotional group, serum ACTH levels decreased significantly in the negative emotion group with statistical difference (P < 0.05). There was no statistical difference in serum ACTH levels between the two groups (P > 0.05).
  
  
  CONCLUSIONS
  The negative emotion of HBLC patients was not related to the serum ACTH level, but to relatively lower-concentration serum NPY levels.
authors.forename: Fu-quan
authors.initials: FQ
authors.lastname: Jiang
authors.forename: Xiao-lin
authors.initials: XL
authors.lastname: Xue
authors.forename: Tian-fang
authors.initials: TF
authors.lastname: Wang
authors.forename: Xiu-yan
authors.initials: XY
authors.lastname: Wu
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D004644:Emotions; D006509:Hepatitis B / Q000097:blood* / Q000523:psychology; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000523:psychology; D009478:Neuropeptide Y; D044967:Serum
chemical_list: D009478:Neuropeptide Y; D000324:Adrenocorticotropic Hormone