title: Beyond static biomarkers--The dynamic response potential of signaling networks as an alternate biomarker?
abstract: In this week's issue of Science Signaling, Fey et al. introduce a new type of biomarker. Using the example of neuroblastoma, the authors demonstrate that patient-specific differences in the computed property (the Hill coefficient) of the dynamics of a pathway involved in cell death signaling outperformed the prognostic capability of any single static biomarker alone or in combination.
authors.affiliation: Merrimack, 1 Kendall Square, Cambridge, MA 02139, USA.
authors.forename: Jaeyeon
authors.initials: J
authors.lastname: Kim
authors.affiliation: Merrimack, 1 Kendall Square, Cambridge, MA 02139, USA. bschoeberl@merrimack.com.
authors.forename: Birgit
authors.initials: B
authors.lastname: Schoeberl
mesh_terms: D015415:Biomarkers; D006801:Humans; D009447:Neuroblastoma; D011379:Prognosis; D015398:Signal Transduction
chemical_list: D015415:Biomarkers