title: Research advances in HMGN5 and cancer.
abstract: High-mobility group nucleosome-binding domain 5 (HMGN5) is a new member of the high-mobility group N (HMGN) protein family that is involved in nucleosomal binding and transcriptional activation. It was first discovered in mouse, and recent studies found that the expressions of HMGN5 in many human cancers were also highly regulated, such as prostate, bladder, breast, and lung and clear cell renal cell carcinoma. Numerous reports have demonstrated that HMGN5 plays significant roles in many biological and pathological conditions, such as in developmental defects, hypersensitivity to stress, embryonic stem cell differentiation, and tumor progression. Importantly, deficiency of HMGN5 has been shown to be linked to cancer cell growth, cell cycle regulation, migration, invasion, and clinical outcomes, and it represents a promising therapeutic target for many malignant tumors. In the present review, we provide an overview of the current knowledge concerning the role of HMGN5 in cancer development and progression.
authors.affiliation: Department of Urology, The Affiliated Hospital of Xuzhou Medical College, 99 Huaihai Road West, Xuzhou, 221002, Jiangsu Province, People's Republic of China.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Shi
authors.affiliation: Department of Urology, The Affiliated Hospital of Xuzhou Medical College, 99 Huaihai Road West, Xuzhou, 221002, Jiangsu Province, People's Republic of China.
authors.forename: Run
authors.initials: R
authors.lastname: Tang
authors.affiliation: Department of Urology, The Affiliated Hospital of Xuzhou Medical College, 99 Huaihai Road West, Xuzhou, 221002, Jiangsu Province, People's Republic of China.
authors.forename: Ding
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Urology, The Affiliated Hospital of Xuzhou Medical College, 99 Huaihai Road West, Xuzhou, 221002, Jiangsu Province, People's Republic of China. sunheyaourology@sina.com.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Sun
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D024001:HMGN Proteins / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism*
chemical_list: D024001:HMGN Proteins; C429289:HMGN5 protein, human; C498963:Hmgn5 protein, mouse; D015534:Trans-Activators
keywords: Apoptosis; Autophagy; Cancer; High-mobility group protein nucleosome-binding domain 5; Metastasis