title: MicroRNA-495 suppresses human renal cell carcinoma malignancy by targeting SATB1.
abstract: Deregulated expression of miRNAs is related to progression and initiation of human cancers. Although miR-495 has identified in various tumors, its expression and function in renal cell carcinoma (RCC) is still unknown. In this study, we found that the expression of miR-495 was downregulated in RCC cell lines and tissues. Ectopic expression of miR-495 induced G0/G1 phase arrest and suppressed cell proliferation and migration in RCC cell lines. We further validated SATB1 was a direct target of miR-495 in RCC. In addition, re-expression of SATB1 reversed the miR-495-induced inhibition of cell proliferation and migration. These data suggest that miR-495 functions as a tumor suppressor and may be a promising therapeutic target in RCC in the future.
authors.affiliation: Department of Urology, Haikou Municipal Hospital Haikou, Hainan, 570208, China ; Department of Urology, Renmin Hospital of Wuhan University Wuhan, Hubei, 430060, China.
authors.forename: Cai
authors.initials: C
authors.lastname: Lv
authors.affiliation: Department of Urology, Haikou Municipal Hospital Haikou, Hainan, 570208, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Bai
authors.affiliation: Department of Urology, Haikou Municipal Hospital Haikou, Hainan, 570208, China.
authors.forename: Zhenxiang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Urology, Renmin Hospital of Wuhan University Wuhan, Hubei, 430060, China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Luo
authors.affiliation: Department of Urology, Renmin Hospital of Wuhan University Wuhan, Hubei, 430060, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
keywords: Renal cell carcinoma; SATB1; miR-495; microRNAs