title: Platelet concentration in platelet concentrates and periodontal regeneration-unscrambling the ambiguity.
abstract: BACKGROUND
  Platelet-rich-plasma (PRP) and Platelet-rich-fibrin (PRF) are extensively used autologous platelet concentrates in periodontal regeneration, and PRF has a better efficacy as compared to PRP. The rationale for this difference has often been attributed to the difference in the structure of the fibrin matrix. However, the effect of concentration of platelets on the regenerative potential of these concentrates is obscure.
  
  
  OBJECTIVE
  The study was conducted to evaluate and compare, clinically and radiographically, the efficacy of PRF and PRP in the treatment of periodontal endosseous defects and to assess the effect of platelet concentration on periodontal regeneration.
  
  
  METHODS
  Twenty intrabony defects were selected and divided into two groups randomly by the coin toss method. Group I received PRP and Group II subjects were treated with PRF. The platelet counts in PRP and PRF were analyzed. Clinical and radiological parameters were assessed at baseline and 3, 6, and 9 months postoperatively.
  
  
  METHODS
  Kruskal-Wallis Chi-square test, Wilcoxon signed rank test, t-test, and Spearman's rank correlation were used for statistical analysis of data.
  
  
  RESULTS
  There was statistically significant improvement in all the parameters in the two groups except in relation to gingival recession. There was a statistically significant difference between the platelet count in Group I and Group II (P = 0.002).
  
  
  CONCLUSIONS
  PRP and PRF appear to have nearly comparable effects in terms of periodontal regeneration. The concentration of platelets appears to play a paradoxical role in regeneration. The regenerative potential of platelets appears to be optimal within a limited range.
authors.affiliation: Department of Periodontics, D A P M R V Dental College, Bengaluru, Karnataka, India.
authors.forename: A
authors.initials: A
authors.lastname: Suchetha
authors.affiliation: Department of Periodontics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, India.
authors.forename: P
authors.initials: P
authors.lastname: Lakshmi
authors.affiliation: Department of Periodontics, D A P M R V Dental College, Bengaluru, Karnataka, India.
authors.forename: Divya
authors.initials: D
authors.lastname: Bhat
authors.affiliation: Department of Periodontics, D A P M R V Dental College, Bengaluru, Karnataka, India.
authors.forename: Darshan B
authors.initials: DB
authors.lastname: Mundinamane
authors.affiliation: Department of Periodontics, Mahatma Gandhi Post Graduate Institute of Dental Sciences, Puducherry, India.
authors.forename: K V
authors.initials: KV
authors.lastname: Soorya
authors.affiliation: Department of Periodontics, K. M. Shah Dental College and Hospital, Vadodara, Gujarat, India.
authors.forename: G Ashit
authors.initials: GA
authors.lastname: Bharwani
keywords: Periodontal regeneration; platelet count; platelet-rich-fibrin; platelet-rich-plasma