title: A Sublethal Swine Model for Defining In Vivo Superantigen-Induced Responses Following Exposure to Staphylococcal Enterotoxin B.
abstract: In vivo responses to bacterially derived superantigen-like toxins have been difficult to define due to the inherent limitations with rodent models and the relevance that the results obtained from such models may, or may not, have for human pathophysiology. Further the use of challenge doses of superantigen toxins that are lethal or supra-lethal complicates analogies to human exposures which are rarely fatal. Here, we utilize the superantigen, staphylococcal enterotoxin B, at doses that are sublethal in a swine model of toxin-induced incapacitation. Relevant dosing using an animal species for which this toxin is a true superantigen distinguishes this model.
authors.affiliation: Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC, USA. klbost@uncc.edu.
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Bost
authors.affiliation: Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC, USA.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Piller
authors.affiliation: Department of Animal Science, North Carolina State University, Raleigh, NC, USA.
authors.forename: Jack
authors.initials: J
authors.lastname: Odle
authors.affiliation: Department of Animal Science, North Carolina State University, Raleigh, NC, USA.
authors.forename: Chad H
authors.initials: CH
authors.lastname: Stahl
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004768:Enterotoxins / Q000276:immunology*; D018836:Inflammation Mediators / Q000097:blood; D013203:Staphylococcal Infections / Q000097:blood / Q000276:immunology* / Q000382:microbiology / Q000401:mortality; D013211:Staphylococcus aureus / Q000276:immunology*; D018089:Superantigens / Q000276:immunology*; D013552:Swine
chemical_list: D004768:Enterotoxins; D018836:Inflammation Mediators; D018089:Superantigens; C031818:enterotoxin B, staphylococcal
keywords: Cytokine analyses; In vivo swine model; Staphylococcal enterotoxin B; Sublethal challenge; Superantigen