title: Andexanet alfa for the reversal of Factor Xa inhibitor related anticoagulation.
abstract: Andexanet alfa is a specific reversal agent for Factor Xa inhibitors. The molecule is a recombinant protein analog of factor Xa that binds to Factor Xa inhibitors and antithrombin:LMWH complex but does not trigger prothrombotic activity. In ex vivo, animal, and volunteer human studies, andexanet alfa (AnXa) was able to dose-dependently reverse Factor Xa inhibition and restore thrombin generation for the duration of drug administration. Further trials are underway to examine its safety and efficacy in the population of patients experiencing FXa inhibitor-related bleeding.
authors.affiliation: a Divisions of Cardiothoracic Anesthesiology & Critical Care Medicine , Duke University Medical Center , Durham , NC , USA.
authors.forename: Kamrouz
authors.initials: K
authors.lastname: Ghadimi
authors.affiliation: b Department of Neurology , Duke University Medical Center , Durham , NC , USA.
authors.forename: Keith E
authors.initials: KE
authors.lastname: Dombrowski
authors.affiliation: a Divisions of Cardiothoracic Anesthesiology & Critical Care Medicine , Duke University Medical Center , Durham , NC , USA.
authors.forename: Jerrold H
authors.initials: JH
authors.lastname: Levy
authors.affiliation: a Divisions of Cardiothoracic Anesthesiology & Critical Care Medicine , Duke University Medical Center , Durham , NC , USA.
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Welsby
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D004353:Drug Evaluation, Preclinical; D015951:Factor Xa / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use*; D065427:Factor Xa Inhibitors / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D011994:Recombinant Proteins / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D065427:Factor Xa Inhibitors; C580915:PRT064445; D011994:Recombinant Proteins; D015951:Factor Xa
keywords: Andexanet alfa; Apixaban; Factor Xa inhibitors; Hemostasis; Morpholines; Prothrombinase; Rivaroxaban; Thiophenes; Thrombin Generation; Thrombosis