title: [MicroRNA regulates animal adipocyte differentiation].
abstract: Adipose tissues play a critical role in the regulation of energy metabolism and homeostasis, and is also an important endocrine organ. Adipocyte differentiation is a complicated physiological process during which mesenchymal stem cells differentiate into adipocytes. This process is synergistically regulated by a large number of transcription factors, hormones and signaling pathway molecules. As a class of endogenous non-coding RNA (ncRNA), microRNAs (miRNAs) regulate gene expression mainly through post-transcriptional translational repression. In recent years, numerous studies have demonstrated that miRNA could have an impact on adipocyte differentiation and adipogenesis by modulating the expression levels of several adipogenic transcription factors and key signaling molecules. In this review, we summarize the mechanism of miRNA in regulating the differentiation of white/brown/beige adipocytes and the relevant signaling pathways and key factors, in the hope of providing theoretical guidance and new thoughts for treating obesity and other metabolic diseases.
authors.affiliation: College of Animal Science and Technology, Institute of Animal Genetics and Breeding, Sichuan Agricultural University,Chengdu 611130, China.
authors.forename: Jin-wei
authors.initials: JW
authors.lastname: Zhang
authors.affiliation: College of Animal Science and Technology, Institute of Animal Genetics and Breeding, Sichuan Agricultural University,Chengdu 611130, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Luo
authors.affiliation: College of Animal Science and Technology, Institute of Animal Genetics and Breeding, Sichuan Agricultural University,Chengdu 611130, China.
authors.forename: Yu-hao
authors.initials: YH
authors.lastname: Wang
authors.affiliation: College of Animal Science and Technology, Institute of Animal Genetics and Breeding, Sichuan Agricultural University,Chengdu 611130, China.
authors.forename: Liu-jun
authors.initials: LJ
authors.lastname: He
authors.affiliation: College of Animal Science and Technology, Institute of Animal Genetics and Breeding, Sichuan Agricultural University,Chengdu 611130, China.
authors.forename: Ming-zhou
authors.initials: MZ
authors.lastname: Li
authors.affiliation: College of Animal Science and Technology, Institute of Animal Genetics and Breeding, Sichuan Agricultural University,Chengdu 611130, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Wang
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000378:metabolism*; D050156:Adipogenesis; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D035683:MicroRNAs / Q000138:chemical synthesis / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs