title: Dihydromyricetin Improves Hypobaric Hypoxia-Induced Memory Impairment via Modulation of SIRT3 Signaling.
abstract: Inadequate oxygen availability-for instance at high altitudes-leads to hippocampal neurodegeneration and memory impairment. Although oxidative stress is one factor, the mechanism underlying the effects of hypobaric hypoxia (HH) are unclear, and effective strategies for preventing the resultant damage to the brain are limited. In the present study, we demonstrate that ingesting dihydromyricetin (DM) protects against memory impairment in adult rats subjected to HH for 7 days, equivalent to an altitude of 5000 m above sea level. Moreover, DM treatment stimulated mitochondrial biogenesis and improved mitochondrial morphology and function, suppressed the generation of reactive oxygen species, and reduced lipid peroxidation in the hippocampus. In HT-22 cells exposed to hypoxic conditions, the neuroprotective effects of DM were shown to be exerted via attenuation of oxidative stress through sirtuin 3-induced forkhead box O3 deacetylation.
authors.affiliation: Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food Safety; Chongqing Medical Nutrition Research Center, Chongqing, 400038, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.affiliation: Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food Safety; Chongqing Medical Nutrition Research Center, Chongqing, 400038, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zou
authors.affiliation: Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food Safety; Chongqing Medical Nutrition Research Center, Chongqing, 400038, People's Republic of China.
authors.forename: Ka
authors.initials: K
authors.lastname: Chen
authors.affiliation: Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food Safety; Chongqing Medical Nutrition Research Center, Chongqing, 400038, People's Republic of China.
authors.forename: Qicheng
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food Safety; Chongqing Medical Nutrition Research Center, Chongqing, 400038, People's Republic of China.
authors.forename: Yanxiang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food Safety; Chongqing Medical Nutrition Research Center, Chongqing, 400038, People's Republic of China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food Safety; Chongqing Medical Nutrition Research Center, Chongqing, 400038, People's Republic of China.
authors.forename: Jundong
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food Safety; Chongqing Medical Nutrition Research Center, Chongqing, 400038, People's Republic of China.
authors.forename: Qianyong
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University; Chongqing Key Laboratory of Nutrition and Food Safety; Chongqing Medical Nutrition Research Center, Chongqing, 400038, People's Republic of China. mimantian@outlook.com.
authors.forename: Mantian
authors.initials: M
authors.lastname: Mi
mesh_terms: D025181:ATP Synthetase Complexes / Q000378:metabolism; D000107:Acetylation; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002460:Cell Line; D044948:Flavonols / Q000494:pharmacology / Q000627:therapeutic use*; D000071316:Forkhead Box Protein O3 / Q000378:metabolism; D006624:Hippocampus / Q000473:pathology; D000860:Hypoxia / Q000150:complications*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy*; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D018696:Neuroprotective Agents / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects; D056566:Sirtuin 3 / Q000378:metabolism*; D013569:Synapses / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D044948:Flavonols; D000071316:Forkhead Box Protein O3; D018696:Neuroprotective Agents; D000255:Adenosine Triphosphate; D025181:ATP Synthetase Complexes; D056566:Sirtuin 3; C472036:dihydromyricetin
keywords: Dihydromyricetin; Free radical; Hypobaric hypoxia; Memory impairment; Mitochondria; Neuroprotection; Oxidative stress; SIRT3