title: Everolimus-Eluting Bioresorbable Vascular Scaffold System in the Treatment of Cardiac Allograft Vasculopathy: the CART (Cardiac Allograft Reparative Therapy) Prospective Multicenter Pilot Study.
abstract: Cardiac allograft vasculopathy (CAV) is a form of accelerated atherosclerosis, which represents the leading cause of late morbidity and mortality after heart transplantation. The recent bioresorbable vascular scaffold (BVS) technology represents a potential novel therapeutic tool, in the context of CAV, by allowing transient scaffolding and concomitant vessel healing. Eligible subjects will be treated by using the Absorb Everolimus-Eluting BVS (Abbott Vascular, Santa Clara, CA, USA), and evaluated at pre-determined time points, up to 3 years since the index procedure. Both clinical and imaging data will be collected in dedicated case report forms (CRF). All imaging data will be analyzed in an independent core laboratory. The primary aim of the study is to evaluate the angiographic performance at 1 year of second-generation Absorb BVS, in heart transplant recipients affected by CAV.
authors.affiliation: Department of Medicine, University of Verona, Piazzale Aristide Stefani n 1, 37126, Verona, Italy. michele.pighi@hotmail.it.
authors.forename: Michele
authors.initials: M
authors.lastname: Pighi
authors.affiliation: Department of Cardiovascular Sciences, European Hospital, Via Portuense, 700, 00149, Rome, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Tomai
authors.affiliation: Department of Cardiovascular Sciences, European Hospital, Via Portuense, 700, 00149, Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Petrolini
authors.affiliation: Department of Cardiovascular Sciences, European Hospital, Via Portuense, 700, 00149, Rome, Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: de Luca
authors.affiliation: Department of Cardiac, Thoracic and Vascular Sciences, University of Padua Medical School, Padua, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tarantini
authors.affiliation: Department of Cardiac, Thoracic and Vascular Sciences, University of Padua Medical School, Padua, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Barioli
authors.affiliation: Department of Cardiology and Cardiac Surgery, A. De Gasperis Niguarda Ca' Granda Hospital, Milan, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Colombo
authors.affiliation: Department of Cardiology and Cardiac Surgery, A. De Gasperis Niguarda Ca' Granda Hospital, Milan, Italy.
authors.forename: Silvio
authors.initials: S
authors.lastname: Klugmann
authors.affiliation: Department of Cardiovascular Sciences, IRCCS Foundation, Policlinico San Matteo, Pavia, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Ferlini
authors.affiliation: Department of Cardiovascular Sciences, IRCCS Foundation, Policlinico San Matteo, Pavia, Italy.
authors.forename: Maurizio Ferrario
authors.initials: MF
authors.lastname: Ormezzano
authors.affiliation: Department of Cardiovascular Sciences, Brotzu Hospital, Cagliari, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Loi
authors.affiliation: Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, Monaldi Hospital, A.O.R.N. dei Colli, Naples, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Calabrò
authors.affiliation: Cardio-thoracic and Respiratory Sciences Department, Second University of Naples, Monaldi Hospital, A.O.R.N. dei Colli, Naples, Italy.
authors.forename: Renato Maria
authors.initials: RM
authors.lastname: Bianchi
authors.affiliation: Department of Cardiac Surgery, University of Verona, Piazzale Aristide Stefani n 1, 37126, Verona, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Faggian
authors.affiliation: Department of Cardiac Surgery, University of Verona, Piazzale Aristide Stefani n 1, 37126, Verona, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Forni
authors.affiliation: Department of Medicine, University of Verona, Piazzale Aristide Stefani n 1, 37126, Verona, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Vassanelli
authors.affiliation: Cardialysis, Rotterdam, The Netherlands.
authors.forename: Marco
authors.initials: M
authors.lastname: Valgimigli
authors.affiliation: Department of Medicine, University of Verona, Piazzale Aristide Stefani n 1, 37126, Verona, Italy.
authors.forename: Flavio
authors.initials: F
authors.lastname: Ribichini
mesh_terms: D020341:Absorbable Implants; D064591:Allografts; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation*; D002317:Cardiovascular Agents / Q000009:adverse effects; D002985:Clinical Protocols; D020099:Coated Materials, Biocompatible; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D000068338:Everolimus / Q000008:administration & dosage* / Q000009:adverse effects; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007558:Italy; D010865:Pilot Projects; D011446:Prospective Studies; D011474:Prosthesis Design; D012107:Research Design; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents; D020099:Coated Materials, Biocompatible; D000068338:Everolimus
keywords: Cardiac allograft vasculopathy; Everolimus-eluting bioresorbable vascular scaffold; Heart transplant