title: From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis.
abstract: The first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retroviral-induced disease. This review will focus on the recent advances in the generation of immunodeficient and human hemato-lymphoid system mice with a particular emphasis on the development of mouse models for HTLV-1-mediated pathogenesis, their present limitations and the challenges yet to be addressed.
authors.affiliation: Laboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, France. eleonore.peres@ens-lyon.fr.|SFR UMS3444 BioSciences Lyon-Gerland-Lyon Sud (UMS3444), 69366 Lyon Cedex 7, France. eleonore.peres@ens-lyon.fr.
authors.forename: Eléonore
authors.initials: E
authors.lastname: Pérès
authors.affiliation: Laboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, France. eugenie.bagdassarian@gmail.com.|SFR UMS3444 BioSciences Lyon-Gerland-Lyon Sud (UMS3444), 69366 Lyon Cedex 7, France. eugenie.bagdassarian@gmail.com.|Master BioSciences, Département de Biologie, ENS Lyon, 69366 Lyon Cedex 7, France. eugenie.bagdassarian@gmail.com.
authors.forename: Eugénie
authors.initials: E
authors.lastname: Bagdassarian
authors.affiliation: Laboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, France. sebastien.this@ens-lyon.fr.|SFR UMS3444 BioSciences Lyon-Gerland-Lyon Sud (UMS3444), 69366 Lyon Cedex 7, France. sebastien.this@ens-lyon.fr.|Master BioSciences, Département de Biologie, ENS Lyon, 69366 Lyon Cedex 7, France. sebastien.this@ens-lyon.fr.
authors.forename: Sébastien
authors.initials: S
authors.lastname: This
authors.affiliation: AIMM Therapeutics, Meibergdreef 59, 1105 BA Amsterdam Zuidoost, The Netherlands. jvillaudy@aimmtherapeutics.com.|Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 BA Amsterdam Zuidoost, The Netherlands. jvillaudy@aimmtherapeutics.com.
authors.forename: Julien
authors.initials: J
authors.lastname: Villaudy
authors.affiliation: Etablissement français du sang, 69007 Lyon, France. dominique.rigal@efs-sante.fr.
authors.forename: Dominique
authors.initials: D
authors.lastname: Rigal
authors.affiliation: Laboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, France. louis.gazzolo@ens-lyon.fr.|SFR UMS3444 BioSciences Lyon-Gerland-Lyon Sud (UMS3444), 69366 Lyon Cedex 7, France. louis.gazzolo@ens-lyon.fr.
authors.forename: Louis
authors.initials: L
authors.lastname: Gazzolo
authors.affiliation: Laboratoire de Biologie Moléculaire de la Cellule, Unité Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 7, France. mducdodo@ens-lyon.fr.|SFR UMS3444 BioSciences Lyon-Gerland-Lyon Sud (UMS3444), 69366 Lyon Cedex 7, France. mducdodo@ens-lyon.fr.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Duc Dodon
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D054884:Host-Pathogen Interactions; D015368:Human T-lymphotropic virus 1 / Q000254:growth & development*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000473:pathology* / Q000821:virology*; D051379:Mice; D016513:Mice, SCID
keywords: HTLV-1; adult T cell leukemia/lymphoma; humanized mouse models; oncogenesis