title: An unprecedented protocol for the synthesis of 3-hydroxy-3-phenacyloxindole derivatives with indolin-2-ones and α-substituted ketones.
abstract: An unprecedented reaction between indolin-2-ones and α-substituted ketones has been developed. Using this protocol, a wide range of biologically important 3-hydroxy-3-phenacyloxindole derivatives could be obtained in good yield (up to 93%) under mild reaction conditions. A possible mechanism of this reaction was tentatively proposed based on some control experiments and MS spectrometry analysis.
authors.affiliation: National Engineering Research Center of Chiral Drugs, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China. yuanwc@cioc.ac.cn.
authors.forename: Mei
authors.initials: M
authors.lastname: Bai
authors.forename: Yong
authors.initials: Y
authors.lastname: You
authors.forename: Yong-Zheng
authors.initials: YZ
authors.lastname: Chen
authors.forename: Guang-Yan
authors.initials: GY
authors.lastname: Xiang
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Xu
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Wei-Cheng
authors.initials: WC
authors.lastname: Yuan
mesh_terms: D018360:Crystallography, X-Ray; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D000078183:Oxindoles
chemical_list: D007211:Indoles; D007659:Ketones; D000078183:Oxindoles; C456900:indolin-2-one; C019188:3-hydroxy-3-phenacyloxindole