title: Toxicokinetics of short-chain chlorinated paraffins in Sprague-Dawley rats following single oral administration.
abstract: Short-chain chlorinated paraffins (SCCPs) have attracted considerable attention for their characteristic of persistent organic pollutants. However, very limited information is available for their toxicokinetic characteristics, limiting the evaluation of their health risks. In this study, we performed a toxicokinetics study to explore the absorption and excretion processes of SCCPs (a mixture of C10-, C11-, C12- and C13-CPs) after a single oral administration to the Sprague-Dawley rats. The toxicokinetic results showed that peak blood concentration of total SCCPs was attained at 2.8 day with Cmax value of 2.3 mg L(-1). The half-lives of total SCCPs in blood for the absorption t1/2 (ka), distribution t1/2 (α) and elimination phases t1/2 (β) were calculated to be 1.0, 1.7 and 6.6 days, respectively. During the 28 days post-dosing, about 27.9% and 3.5% of orally administrated SCCPs were excreted through feces and urine without metabolism, respectively. Congener group abundance profiles indicate a relative increase of Cl5-SCCPs in blood and urine in the elimination stage, and a higher accumulation of Cl8-10-SCCPs in feces. The distribution discrepancies of SCCPs congener groups in blood and excreta were more dependent on chlorine contents than on carbon chain lengths.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China; Graduate School of Chinese Academy of Science, Beijing, 100049, China.
authors.forename: Ningbo
authors.initials: N
authors.lastname: Geng
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. Electronic address: hjzhang@dicp.ac.cn.
authors.forename: Haijun
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Safety Evaluation Center of Shenyang Research Institute of Chemical Industry Ltd, Shenyang, 110021, China.
authors.forename: Liguo
authors.initials: L
authors.lastname: Xing
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
authors.forename: Baoqin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China; Graduate School of Chinese Academy of Science, Beijing, 100049, China.
authors.forename: Feidi
authors.initials: F
authors.lastname: Wang
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China; Graduate School of Chinese Academy of Science, Beijing, 100049, China.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Ren
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. Electronic address: chenjp@dicp.ac.cn.
authors.forename: Jiping
authors.initials: J
authors.lastname: Chen
mesh_terms: D065567:Absorption, Physiological; D000284:Administration, Oral; D000818:Animals; D004785:Environmental Pollutants / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D005243:Feces / Q000737:chemistry; D006207:Half-Life; D006843:Hydrocarbons, Chlorinated / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D008657:Metabolic Clearance Rate; D010232:Paraffin / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D010232:Paraffin
keywords: Blood; Half-life; Rat; SCCPs; Toxicokinetics