title: Formal Ir-Catalyzed Ligand-Enabled Ortho and Meta Borylation of Aromatic Aldehydes via in Situ-Generated Imines.
abstract: The ligand-enabled development of ortho and meta C-H borylation of aromatic aldehydes is reported. It was envisaged that while ortho borylation could be achieved using tert-butylamine as the traceless protecting/directing group, meta borylation proceeds via an electrostatic interaction and a secondary interaction between the ligand of the catalyst and the substrate. These ligand-substrate electrostatic interactions and secondary B-N interactions provide an unprecedented controlling factor for meta-selective C-H activation/borylation.
authors.affiliation: Center of Bio-Medical Research, Division of Molecular Synthesis & Drug Discovery, Sanjay Gandhi Post Graduate Institute of Medical Sciences , Raebareli Road, Lucknow, Uttar Pradesh 226014, India.
authors.forename: Ranjana
authors.initials: R
authors.lastname: Bisht
authors.affiliation: Center of Bio-Medical Research, Division of Molecular Synthesis & Drug Discovery, Sanjay Gandhi Post Graduate Institute of Medical Sciences , Raebareli Road, Lucknow, Uttar Pradesh 226014, India.
authors.forename: Buddhadeb
authors.initials: B
authors.lastname: Chattopadhyay