title: Barriers and facilitators towards fertility preservation care for cancer patients: a meta-synthesis.
abstract: Infertility is a potential late-effect of cancer treatment, which negatively impact on young cancer survivors' quality of life. This paper aims to synthesise factors that influence patients', carers' and healthcare professionals' decision to engage in fertility preservation programmes at the time of cancer diagnosis. Four databases and grey literature were systematically searched to identify qualitative and mixed-method studies published between 2000 and 2015. Thematic framework and synthesis were used to analyse and synthesise the data. Thirty-seven papers were selected and represented. Factors that affect engagement of patients, carers and healthcare providers in fertility preservation care can be grouped as intrinsic and extrinsic. Intrinsic factors include patients' attitudes, health beliefs and health literacy; clinicians' approaches and skills; as well as doctor-patient relationships. Extrinsic factors include fertility preservation care resources and institutional characteristics. We conclude that existing qualitative literature highlights the complex convergences of intrinsic and extrinsic factors that impede successful engagement in fertility preservation care. Addressing these factors could help cancer survivors achieve better health outcomes and improve their wellbeing. Potential solutions include attitudinal changes and organisational skill reforms across the health community that will help ensure a person's goals are always at the centre of their cancer care.
authors.affiliation: Newcastle Fertility Centre, International Centre for Life, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
authors.forename: N
authors.initials: N
authors.lastname: Panagiotopoulou
authors.affiliation: Obstetrics and Gynaecology Department, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
authors.forename: N
authors.initials: N
authors.lastname: Ghuman
authors.affiliation: Institute of Human Genetics, International Centre for Life, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: R
authors.initials: R
authors.lastname: Sandher
authors.affiliation: Institute of Human Genetics, International Centre for Life, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: M
authors.initials: M
authors.lastname: Herbert
authors.affiliation: Newcastle Fertility Centre, International Centre for Life, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Stewart
mesh_terms: D001291:Attitude of Health Personnel; D001294:Attitude to Health; D000073116:Cancer Survivors / Q000523:psychology; D017028:Caregivers / Q000523:psychology; D000066491:Clinical Decision-Making; D059247:Fertility Preservation / Q000379:methods* / Q000523:psychology; D006801:Humans; D007246:Infertility / Q000517:prevention & control; D009369:Neoplasms / Q000150:complications* / Q000523:psychology / Q000628:therapy; D000072103:Oncologists; D017060:Patient Satisfaction; D010817:Physician-Patient Relations; D010818:Practice Patterns, Physicians'; D011788:Quality of Life
keywords: barriers; cancer patients; facilitators; fertility preservation; healthcare providers; meta-synthesis