title: A Phase II Study of Ifosfamide, Carboplatin, and Epirubicin (ICE) Combination Chemotherapy for Extensive Disease of Small Cell Lung Cancer.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of ifosfamide, carboplatin and epirubicin (ICE) combination chemotherapy for extensive disease small cell lung cancer (SCLC) patients, who had received no previous chemotherapy, we performed phase II trial between August 1998 and January 2001.
  
  
  METHODS
  The study group comprised of 21 patients. Ifosfamide, 1,500 mg/m2, was given with mesna, 900 mg/m2, intravenously for 12 hours on days 1, 2 and 3, and carboplatin, 4.5 mg/ml/min, for target AUC, and epirubicin, 60 mg/m2, were given intravenously for 90 minutes on day 1. The cycle of treatment was repeated at 4 week intervals.
  
  
  RESULTS
  Twenty-one patients with extensive disease SCLC were treated at Hallym University between August 1998 and January 2001. One patient was unable to be evaluated because of lost to follow-up. Of the 20 patients able to be evaluated, an objective response was observed in 13 (65%). There were no complete responses. The median response duration, time to progression and median overall survival were 15.4, 18.3 and 34 weeks, respectively. Toxicities were acceptable, with dose reduction for myelosuppression necessary in only a minority of the patients. A total of 85 cycles of chemotherapy were given to the patients. The median number of cycles completed was 4. Grade III and IV hematological toxicities included anemia (4.7%), neutropenia (3.5%) and thrombocytopenia (3.5%). Most non-hematological toxicities were grade I or II.
  
  
  CONCLUSIONS
  These results suggested that ICE combination chemotherapy for extensive disease SCLC is effective, and can be safely administered with acceptable toxicities.
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Byun
authors.forename: In Sook
authors.initials: IS
authors.lastname: Woo
authors.forename: Hun Ho
authors.initials: HH
authors.lastname: Song
authors.forename: Keun Seok
authors.initials: KS
authors.lastname: Lee
authors.forename: Jin Seok
authors.initials: JS
authors.lastname: Ahn
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Jang
authors.forename: Jung Ae
authors.initials: JA
authors.lastname: Lee
authors.forename: Young Lee
authors.initials: YL
authors.lastname: Park
authors.forename: Young Suk
authors.initials: YS
authors.lastname: Park
keywords: Carboplatin; Chemotherapy; Epirubicin; Ifosfamide; Small cell lung cancer