title: Risk of renal cancer in liver transplant recipients: A systematic review and meta-analysis.
abstract: Liver transplantation is associated with a significantly increased risk of de novo malignancies, but for renal cancer this risk is less clear. We therefore performed a meta-analysis of published studies to determine whether renal cancer risk in liver transplant recipients (LTRs) was increased. To obtain a more precise conclusion, a systematic search was performed in PubMed and Web of Science databases until June 10, 2015. Standardized incidence ratio (SIR) corresponding 95% confidence interval (CI) were used to estimate risk of renal cancer in LTRs. Heterogeneity test, sensitivity analysis, and publishing bias were also performed. We identified 8 eligible studies and performed a meta-analysis on data of 49,654 LTRs with a total follow-up of 121,514.6 patient-years. The SIR for renal cancer was identified a 3.275-fold higher SIR (95% CI: 1.857-5.777; P < 0.001) in LTRs compared with the general population. This systematic review and meta-analysis demonstrated that the LTRs was associated with a significant increase in the incidence of renal cancer. Such association suggests that yearly routine post-transplant surveillance is need for renal cancer in LTRs.
authors.affiliation: Department of Neurosurgery, Subei People's Hospital of Jiangsu Province, No.98 Nantong West Road, Yangzhou, 225001, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Zhu
authors.affiliation: The School of Medicine, Jiangsu University, No.301 Xuefu Road, Zhenjiang, 212001, China.
authors.forename: Jing-zhe
authors.initials: JZ
authors.lastname: Wang
authors.affiliation: The School of Medicine, Jiangsu University, No.301 Xuefu Road, Zhenjiang, 212001, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: The School of Medicine, Jiangsu University, No.301 Xuefu Road, Zhenjiang, 212001, China.
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Subei People's Hospital of Jiangsu Province, No.98 Nantong West Road, Yangzhou, 225001, China. Electronic address: chenpin1987@126.com.
authors.forename: Pen
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Subei People's Hospital of Jiangsu Province, No.98 Nantong West Road, Yangzhou, 225001, China. Electronic address: wangcunzu@ujs.edu.cn.
authors.forename: Cun-zu
authors.initials: CZ
authors.lastname: Wang
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015994:Incidence; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000209:etiology*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
keywords: Liver transplantation; Meta-analysis; Renal cancer; Standardized incidence ratio