title: Peak flow velocities in the ascending aorta-real-time phase-contrast magnetic resonance imaging vs. cine magnetic resonance imaging and echocardiography.
abstract: This prospective study of eight healthy volunteers evaluates peak flow velocities (PFV) in the ascending aorta using real-time phase-contrast magnetic resonance imaging (MRI) in comparison to cine phase-contrast MRI and echocardiography. Flow measurements by echocardiography and cine phase-contrast MRI with breath-holding were performed according to clinical standards. Real-time phase-contrast MRI at 40 ms temporal resolution and 1.3 mm in-plane resolution was based on highly undersampled radial fast low-angle shot (FLASH) sequences with image reconstruction by regularized nonlinear inversion (NLINV). Evaluations focused on the determination of PFV. Linear regressions and Bland-Altman plots were used for comparisons of methods. When averaged across subjects, real-time phase-contrast MRI resulted in PFV of 120±20 cm s(-1) (mean ± SD) in comparison to 122±16 cm s(-1) for cine MRI and 124±20 cm s(-1) for echocardiography. The maximum deviations between real-time phase-contrast MRI and echocardiography ranged from -20 to +14 cm s(-1) (cine MRI: -10 to +12 cm s(-1)). Thus, in general, real-time phase-contrast MRI of cardiac outflow revealed quantitative agreement with cine MRI and echocardiography. The advantages of real-time MRI are measurements during free breathing and access to individual cardiac cycles.
authors.affiliation: 1 Institute for Diagnostic and Interventional Radiology, Heart Center, University Medical Center Göttingen, Göttingen, Germany ; 2 German Centre for Cardiovascular Research, DZHK, partnersite Göttingen, Germany ; 3 Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany ; 4 Department of Cardiology and Pneumology, Heart Center, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Jan M
authors.initials: JM
authors.lastname: Sohns
authors.affiliation: 1 Institute for Diagnostic and Interventional Radiology, Heart Center, University Medical Center Göttingen, Göttingen, Germany ; 2 German Centre for Cardiovascular Research, DZHK, partnersite Göttingen, Germany ; 3 Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany ; 4 Department of Cardiology and Pneumology, Heart Center, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Johannes T
authors.initials: JT
authors.lastname: Kowallick
authors.affiliation: 1 Institute for Diagnostic and Interventional Radiology, Heart Center, University Medical Center Göttingen, Göttingen, Germany ; 2 German Centre for Cardiovascular Research, DZHK, partnersite Göttingen, Germany ; 3 Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany ; 4 Department of Cardiology and Pneumology, Heart Center, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Arun A
authors.initials: AA
authors.lastname: Joseph
authors.affiliation: 1 Institute for Diagnostic and Interventional Radiology, Heart Center, University Medical Center Göttingen, Göttingen, Germany ; 2 German Centre for Cardiovascular Research, DZHK, partnersite Göttingen, Germany ; 3 Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany ; 4 Department of Cardiology and Pneumology, Heart Center, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: K Dietmar
authors.initials: KD
authors.lastname: Merboldt
authors.affiliation: 1 Institute for Diagnostic and Interventional Radiology, Heart Center, University Medical Center Göttingen, Göttingen, Germany ; 2 German Centre for Cardiovascular Research, DZHK, partnersite Göttingen, Germany ; 3 Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany ; 4 Department of Cardiology and Pneumology, Heart Center, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Voit
authors.affiliation: 1 Institute for Diagnostic and Interventional Radiology, Heart Center, University Medical Center Göttingen, Göttingen, Germany ; 2 German Centre for Cardiovascular Research, DZHK, partnersite Göttingen, Germany ; 3 Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany ; 4 Department of Cardiology and Pneumology, Heart Center, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Fasshauer
authors.affiliation: 1 Institute for Diagnostic and Interventional Radiology, Heart Center, University Medical Center Göttingen, Göttingen, Germany ; 2 German Centre for Cardiovascular Research, DZHK, partnersite Göttingen, Germany ; 3 Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany ; 4 Department of Cardiology and Pneumology, Heart Center, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Wieland
authors.initials: W
authors.lastname: Staab
authors.affiliation: 1 Institute for Diagnostic and Interventional Radiology, Heart Center, University Medical Center Göttingen, Göttingen, Germany ; 2 German Centre for Cardiovascular Research, DZHK, partnersite Göttingen, Germany ; 3 Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany ; 4 Department of Cardiology and Pneumology, Heart Center, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Frahm
authors.affiliation: 1 Institute for Diagnostic and Interventional Radiology, Heart Center, University Medical Center Göttingen, Göttingen, Germany ; 2 German Centre for Cardiovascular Research, DZHK, partnersite Göttingen, Germany ; 3 Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany ; 4 Department of Cardiology and Pneumology, Heart Center, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Lotz
authors.affiliation: 1 Institute for Diagnostic and Interventional Radiology, Heart Center, University Medical Center Göttingen, Göttingen, Germany ; 2 German Centre for Cardiovascular Research, DZHK, partnersite Göttingen, Germany ; 3 Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany ; 4 Department of Cardiology and Pneumology, Heart Center, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Unterberg-Buchwald
keywords: Aortic flow; echocardiography; peak flow velocity (PFV); phase-contrast MRI; real-time MRI