title: Letter to the Editor regarding "RIFM fragrance ingredient safety assessment, linalyl acetate, CAS registry number 115-95-7" by Api et al., 2015.
abstract: Present letter is aimed at clarifying some critical points highlighted by Api et al. as major limits for the reliability of our data on the genotoxicity of linalyl acetate. Particularly, we explained the choice of the study design and methodology applied for carrying out the Ames test and the micronucleus assay.
authors.affiliation: Department of Physiology and Pharmacology, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy. Electronic address: antonella.disotto@uniroma1.it.
authors.forename: Antonella
authors.initials: A
authors.lastname: Di Sotto
authors.affiliation: Department of Physiology and Pharmacology, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Mazzanti
mesh_terms: D003257:Consumer Product Safety; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D023381:Endpoint Determination; D006801:Humans; D019055:No-Observed-Adverse-Effect Level; D010476:Perfume; D012042:Registries; D015203:Reproducibility of Results; D018570:Risk Assessment; D018675:Toxicity Tests
chemical_list: D010476:Perfume
keywords: Ames test; Genotoxicity; Impurities; Linalyl acetate; Micronbucleus assay