title: Recent considerations in the use of recombinant interferon gamma for biological therapy of atopic dermatitis.
abstract: BACKGROUND
  Atopic dermatitis (AD) is the most common inflammatory skin disease in the general population. There are different endophenotypes of AD that likely have a unique immune and molecular basis, such as those who are predisposed to eczema herpeticum, or Staphylococcus aureus infections.
  
  
  METHODS
  In this review, we highlight the endophenotypes of AD where reduced interferon gamma expression may be playing a role. Additionally, we review the potential role of recombinant interferon gamma therapy in the treatment of atopic dermatitis and the particular phenotypes that may benefit from this treatment.
  
  
  CONCLUSIONS
  Recombinant interferon gamma treatment will likely benefit the pediatric population with AD, as well as those with susceptibilities for skin infections. Future studies are needed to elucidate whether IFN-γ may reduce the prevalence of skin infection in AD.
authors.affiliation: a Division of Pediatric Allergy-Immunology, Department of Pediatrics , National Jewish Health , Denver , CO , USA.
authors.forename: Kanwaljit
authors.initials: K
authors.lastname: Brar
authors.affiliation: a Division of Pediatric Allergy-Immunology, Department of Pediatrics , National Jewish Health , Denver , CO , USA.|b Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology , The State Key Clinical Specialty in Allergy, The Second Affiliated Hospital of Guangzhou Medical University , Guangzhou , China.
authors.forename: Donald Y M
authors.initials: DY
authors.lastname: Leung
mesh_terms: D001691:Biological Therapy; D003876:Dermatitis, Atopic / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use*; D011994:Recombinant Proteins; D018417:Th1 Cells / Q000276:immunology
chemical_list: D011994:Recombinant Proteins; D007371:Interferon-gamma
keywords: Atopic dermatitis; biological; eczema herpeticum; interferon gamma; skin infection