title: Voice characteristics associated with polycystic ovary syndrome.
abstract: To test the assumption that voice is changed in polycystic ovary syndrome (PCOS) and identify changes that occur.
  
  
  
  Cross-sectional pilot study.
  
  
  
  Thirty patients with PCOS and a control group of 22 age-matched and body mass index-matched healthy women were included. Demographic data, anthropometric measurement, serum androgens, and Voice Handicap Index-10 were determined. Transnasal fiberoptic laryngoscopy and rigid stroboscopy were performed. Supraglottic hyperfunction was assessed during fiberoptic laryngoscopy. Presence of supraglottic hyperfunction was interpreted as abnormal muscle tension pattern. Glottal closure configuration and vibratory wave characteristics were evaluated via stroboscopy. Acoustic analysis was performed with the Dr. Speech software program version 4 (Tiger DRS Inc., Seattle, WA).
  
  
  
  Voice complaints and acoustic parameters were similar between groups, whereas serum androgens were significantly higher in patients (P < 0.001). Laryngeal examination detected pathology in 17 (56.7%) patients and two (9.1%) controls (P < 0.001). Fiberoptic examination determined supraglottic hyperfunction in 11 patients but in only two controls (P = 0.023). In stroboscopy, incomplete glottal closure configuration and impaired vocal fold vibration were present in 10 and 11 patients, respectively, whereas only one control had glottal closure abnormality and none of the controls had abnormal vibration (P = 0.028 and P = 0.001, respectively).
  
  
  
  Abnormal muscle tension patterns and impaired vocal fold vibration are frequent among patients with PCOS; but they are not accompanied by increased vocal symptoms or deteriorated acoustic voice parameters. This may be important for professional voice users or in extensive or extraordinary voice use demands in patients with PCOS.
  
  
  
  3b. Laryngoscope, 126:2067-2072, 2016.
authors.affiliation: Department of Endocrinology and Metabolism, Kartal Dr. Lutfi Kirdar Research and Training Hospital, Istanbul, Turkey.
authors.forename: Kadriye
authors.initials: K
authors.lastname: Aydin
authors.affiliation: Department of Otorhinolaryngology, Kartal Dr. Lutfi Kirdar Research and Training Hospital, Istanbul, Turkey.
authors.forename: Sevtap
authors.initials: S
authors.lastname: Akbulut
authors.affiliation: Etimesgut State Hospital, Ankara, Turkey.
authors.forename: Mehmet Gokhan
authors.initials: MG
authors.lastname: Demir
authors.affiliation: Department of Family Medicine, Kartal Dr. Lutfi Kirdar Research and Training Hospital, Istanbul, Turkey.
authors.forename: Sevin
authors.initials: S
authors.lastname: Demir
authors.affiliation: Department of Endocrinology and Metabolism, Kartal Dr. Lutfi Kirdar Research and Training Hospital, Istanbul, Turkey.
authors.forename: Aysenur
authors.initials: A
authors.lastname: Ozderya
authors.affiliation: Department of Endocrinology and Metabolism, Kartal Dr. Lutfi Kirdar Research and Training Hospital, Istanbul, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Temizkan
authors.affiliation: Department of Family Medicine, Kartal Dr. Lutfi Kirdar Research and Training Hospital, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sargin
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007830:Larynx / Q000503:physiopathology; D010865:Pilot Projects; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D014831:Voice / Q000502:physiology*; D055815:Young Adult
keywords: Polycystic ovary syndrome; hyperandrogenism; muscle tension dysphonia; vocal fold vibration; voice