title: Protein aggregation, structural disorder and RNA-binding ability: a new approach for physico-chemical and gene ontology classification of multiple datasets.
abstract: BACKGROUND
  Comparison between multiple protein datasets requires the choice of an appropriate reference system and a number of variables to describe their differences. Here we introduce an innovative approach to discriminate multiple protein datasets (multiCM) and to measure enrichments in gene ontology terms (cleverGO) using semantic similarities.
  
  
  RESULTS
  We illustrate the powerfulness of our approach by investigating the links between RNA-binding ability and other protein features, such as structural disorder and aggregation, in S. cerevisiae, C. elegans, M. musculus and H. sapiens. Our results are in striking agreement with available experimental evidence and unravel features that are key to understand the mechanisms regulating cellular homeostasis.
  
  
  CONCLUSIONS
  In an intuitive way, multiCM and cleverGO provide accurate classifications of physico-chemical features and annotations of biological processes, molecular functions and cellular components, which is extremely useful for the discovery and characterization of new trends in protein datasets. The multiCM and cleverGO can be freely accessed on the Web at http://www.tartaglialab.com/cs_multi/submission and http://www.tartaglialab.com/GO_analyser/universal . Each of the pages contains links to the corresponding documentation and tutorial.
authors.affiliation: Gene Function and Evolution, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003, Barcelona, Spain.|Universitat Pompeu Fabra (UPF), 08003, Barcelona, Spain.
authors.forename: Petr
authors.initials: P
authors.lastname: Klus
authors.affiliation: Gene Function and Evolution, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003, Barcelona, Spain.|Universitat Pompeu Fabra (UPF), 08003, Barcelona, Spain.
authors.forename: Riccardo Delli
authors.initials: RD
authors.lastname: Ponti
authors.affiliation: Gene Function and Evolution, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003, Barcelona, Spain.|Universitat Pompeu Fabra (UPF), 08003, Barcelona, Spain.
authors.forename: Carmen Maria
authors.initials: CM
authors.lastname: Livi
authors.affiliation: Gene Function and Evolution, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003, Barcelona, Spain. gian.tartaglia@crg.es.|Universitat Pompeu Fabra (UPF), 08003, Barcelona, Spain. gian.tartaglia@crg.es.|Institució Catalana de Recerca i Estudis Avançats (ICREA), 23 Passeig Lluís Companys, 08010, Barcelona, Spain. gian.tartaglia@crg.es.
authors.forename: Gian Gaetano
authors.initials: GG
authors.lastname: Tartaglia
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods; D015394:Molecular Structure; D066263:Protein Aggregation, Pathological; D016601:RNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*; D012984:Software; D012995:Solubility; D013329:Structure-Activity Relationship
chemical_list: D016601:RNA-Binding Proteins