title: Incidence of rhegmatogenous retinal detachment after bag-in-the-lens intraocular lens implantation.
abstract: OBJECTIVE
  To determine the incidence of rhegmatogenous retinal detachment (RRD) and associated risk factors after phacoemulsification and bag-in-the-lens intraocular lens (IOL) implantation.
  
  
  METHODS
  Antwerp University Hospital, Department of Ophthalmology, Antwerp, Belgium.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  All consecutive bag-in-the-lens IOL implantations performed between January 2001 and December 2007 were included, with the exception of combined procedures and IOL exchanges. The retinal detachment (RD) incidence was studied in the total cohort, in a subgroup of patients with 1 to 5 years of follow-up, and finally in the group remaining after exclusion of all risk factors except gender.
  
  
  RESULTS
  RD after bag-in-the-lens IOL implantation in 1323 eyes with an average follow-up of 44.75 months (range 0 to 152 months) was found in 19 eyes (1.44%). The 1-year RD incidence was 0.49% (5 RD cases in 1024 eyes) (0.00% in patients without risk factors). The 2-year cumulative RD incidence was 0.84% (9 RD cases in 931 eyes; 0.15% without risk factors). Four clinically significant risk factors were confirmed: male gender, young age at time of surgery (<60 years), axial myopia (axial length ≥25 mm), and history of contralateral RD in the total cohort.
  
  
  CONCLUSIONS
  The RRD incidence following bag-in-the-lens IOL implantation was comparable to that seen after lens-in-the-bag (LIB) implantation. The wide variation in study design in the literature precludes direct comparison, so there is a need for standardization in evaluating RRD incidence after cataract surgery. Future prospective studies should consider patients with and without risk factors (except gender) separately.
  
  
  BACKGROUND
  Prof. dr. M.J. Tassignon has intellectual property rights to the bag-in-the-lens intraocular lens (U.S. patent 6 027 531; EU patent 009406794; PCT/120268), which is licensed to Morcher GmbH, Stuttgart, Germany.
authors.affiliation: From the Department of Ophthalmology (Tassignon, Van den Heurck, Boven, Van Looveren, Dhubhghaill, Mathysen) Antwerp University Hospital, Edegem, Antwerp, Belgium; Faculty of Medicine and Health Sciences (Tassignon, Van den Heurck, Boven, Jan Van Looveren, Wouters, Mathysen), University of Antwerp, Wilrijk, Antwerp, Belgium; Department of Scientific Coordination-Biostatistics (Wouters), Antwerp University Hospital, Edegem, Antwerp, Belgium; Department of Ophthalmology (Bali), Clinique du Parc Léopold, Brussels, Belgium.
authors.forename: Marie-José
authors.initials: MJ
authors.lastname: Tassignon
authors.affiliation: From the Department of Ophthalmology (Tassignon, Van den Heurck, Boven, Van Looveren, Dhubhghaill, Mathysen) Antwerp University Hospital, Edegem, Antwerp, Belgium; Faculty of Medicine and Health Sciences (Tassignon, Van den Heurck, Boven, Jan Van Looveren, Wouters, Mathysen), University of Antwerp, Wilrijk, Antwerp, Belgium; Department of Scientific Coordination-Biostatistics (Wouters), Antwerp University Hospital, Edegem, Antwerp, Belgium; Department of Ophthalmology (Bali), Clinique du Parc Léopold, Brussels, Belgium.
authors.forename: Jonas J I
authors.initials: JJ
authors.lastname: Van den Heurck
authors.affiliation: From the Department of Ophthalmology (Tassignon, Van den Heurck, Boven, Van Looveren, Dhubhghaill, Mathysen) Antwerp University Hospital, Edegem, Antwerp, Belgium; Faculty of Medicine and Health Sciences (Tassignon, Van den Heurck, Boven, Jan Van Looveren, Wouters, Mathysen), University of Antwerp, Wilrijk, Antwerp, Belgium; Department of Scientific Coordination-Biostatistics (Wouters), Antwerp University Hospital, Edegem, Antwerp, Belgium; Department of Ophthalmology (Bali), Clinique du Parc Léopold, Brussels, Belgium.
authors.forename: Kim B M
authors.initials: KB
authors.lastname: Boven
authors.affiliation: From the Department of Ophthalmology (Tassignon, Van den Heurck, Boven, Van Looveren, Dhubhghaill, Mathysen) Antwerp University Hospital, Edegem, Antwerp, Belgium; Faculty of Medicine and Health Sciences (Tassignon, Van den Heurck, Boven, Jan Van Looveren, Wouters, Mathysen), University of Antwerp, Wilrijk, Antwerp, Belgium; Department of Scientific Coordination-Biostatistics (Wouters), Antwerp University Hospital, Edegem, Antwerp, Belgium; Department of Ophthalmology (Bali), Clinique du Parc Léopold, Brussels, Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: Van Looveren
authors.affiliation: From the Department of Ophthalmology (Tassignon, Van den Heurck, Boven, Van Looveren, Dhubhghaill, Mathysen) Antwerp University Hospital, Edegem, Antwerp, Belgium; Faculty of Medicine and Health Sciences (Tassignon, Van den Heurck, Boven, Jan Van Looveren, Wouters, Mathysen), University of Antwerp, Wilrijk, Antwerp, Belgium; Department of Scientific Coordination-Biostatistics (Wouters), Antwerp University Hospital, Edegem, Antwerp, Belgium; Department of Ophthalmology (Bali), Clinique du Parc Léopold, Brussels, Belgium.
authors.forename: Kristien
authors.initials: K
authors.lastname: Wouters
authors.affiliation: From the Department of Ophthalmology (Tassignon, Van den Heurck, Boven, Van Looveren, Dhubhghaill, Mathysen) Antwerp University Hospital, Edegem, Antwerp, Belgium; Faculty of Medicine and Health Sciences (Tassignon, Van den Heurck, Boven, Jan Van Looveren, Wouters, Mathysen), University of Antwerp, Wilrijk, Antwerp, Belgium; Department of Scientific Coordination-Biostatistics (Wouters), Antwerp University Hospital, Edegem, Antwerp, Belgium; Department of Ophthalmology (Bali), Clinique du Parc Léopold, Brussels, Belgium.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Bali
authors.affiliation: From the Department of Ophthalmology (Tassignon, Van den Heurck, Boven, Van Looveren, Dhubhghaill, Mathysen) Antwerp University Hospital, Edegem, Antwerp, Belgium; Faculty of Medicine and Health Sciences (Tassignon, Van den Heurck, Boven, Jan Van Looveren, Wouters, Mathysen), University of Antwerp, Wilrijk, Antwerp, Belgium; Department of Scientific Coordination-Biostatistics (Wouters), Antwerp University Hospital, Edegem, Antwerp, Belgium; Department of Ophthalmology (Bali), Clinique du Parc Léopold, Brussels, Belgium.
authors.forename: Sorcha
authors.initials: S
authors.lastname: Ní Dhubhghaill
authors.affiliation: From the Department of Ophthalmology (Tassignon, Van den Heurck, Boven, Van Looveren, Dhubhghaill, Mathysen) Antwerp University Hospital, Edegem, Antwerp, Belgium; Faculty of Medicine and Health Sciences (Tassignon, Van den Heurck, Boven, Jan Van Looveren, Wouters, Mathysen), University of Antwerp, Wilrijk, Antwerp, Belgium; Department of Scientific Coordination-Biostatistics (Wouters), Antwerp University Hospital, Edegem, Antwerp, Belgium; Department of Ophthalmology (Bali), Clinique du Parc Léopold, Brussels, Belgium. Electronic address: danny.mathysen@uza.be.
authors.forename: Danny G P
authors.initials: DG
authors.lastname: Mathysen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058442:Capsule Opacification / Q000517:prevention & control; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D019654:Lens Implantation, Intraocular / Q000009:adverse effects* / Q000379:methods; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification / Q000009:adverse effects*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011474:Prosthesis Design; D012163:Retinal Detachment / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors