title: [Application of spatial working memory task fMRI in evaluation of primary insomnia patient's cognitive dysfunction].
abstract: OBJECTIVE
  To explore abnormal brain activation of spatial working memory in primary insomnia and its potential neuromechanism.
  
  
  METHODS
  we recruited 30 cases primary insomnia (PI) patients and 30 cases age, gender matched healthy control (HC) subjects from July 2013 to December 2013, the diagnosis of primary insomnia matched the diagnosis criterion of DSM-IV and Classification and diagnostic criteria of mental disorders in China third edition (CCMD-3). All the subjects attended the tests of PSQI, HAMA, HAMD and index of spatial working memory. And then, we collected the data of routine MRI and spatial working memory task fMRI on 3.0 T MRI scanner. After that, we used SPM8 and REST1.8 to analyze the fMRI data, compared difference of PSQI, HAMA, HAMD, index of spatial working memory and brain activation of spatial working memory between PI group and HC group.
  
  
  RESULTS
  There were significant difference between PI group and HC group in PSQI, HAMA, HAMD and index of spatial working memory (P < 0.05). In the spatial working memory related activate brain region, compared with HC group, left temporal lobe, occipital lobe and right frontal lobe activation increased and bilateral parahippocampalis, temporal cortex, frontal cortex and superior parietal lobule activation reduced in PI group.
  
  
  CONCLUSIONS
  Spatial working memory task fMRI revealed the pathological mechanisms of cognitive dysfunction of clinical spatial working memory and emotional disorder in primary insomnia patients.
authors.affiliation: Department of Radiology, People's Hospital of Zhengzhou University, Zhengzhou 450003, China.
authors.forename: Shewei
authors.initials: S
authors.lastname: Dou
authors.forename: Enfeng
authors.initials: E
authors.lastname: Wang
authors.forename: Hongju
authors.initials: H
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Tong
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Zhang
authors.forename: Dapeng
authors.initials: D
authors.lastname: Shi
authors.forename: Jingliang
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Email: shyliyongli@126.com.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Li
mesh_terms: D001921:Brain; D002681:China; D003071:Cognition; D003072:Cognition Disorders; D006801:Humans; D008279:Magnetic Resonance Imaging; D008570:Memory, Short-Term; D007319:Sleep Initiation and Maintenance Disorders