title: Label-free ultrasensitive detection of telomerase activity via multiple telomeric hemin/G-quadruplex triggered polyaniline deposition and a DNA tetrahedron-structure regulated signal.
abstract: Label-free detection of telomerase activity was done by using telomeric hemin/G-quadruplex triggered polyaniline deposition, not only on themselves but also on the DNA tetrahedron-structure (DTS). DTS size has a great impact on telomerase accessibility, reactivity and detection sensitivity. The method has been used to evaluate bladder cancer development.
authors.affiliation: Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China. wei_wei98@163.com.
authors.forename: Yuanjian
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Food Science and Technology, Henan University of Technology, Zhengzhou, 450001, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wei
authors.affiliation: Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China. wei_wei98@163.com.
authors.forename: Xu
authors.initials: X
authors.lastname: Liu
authors.affiliation: Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China. wei_wei98@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: Central Laboratory, The Second Affiliated Hospital of Southeast University, Nanjing, 210003, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China. wei_wei98@163.com.
authors.forename: Yuanjian
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China. wei_wei98@163.com.
authors.forename: Songqin
authors.initials: S
authors.lastname: Liu
mesh_terms: D000814:Aniline Compounds / Q000378:metabolism*; D006427:Hemin / Q000378:metabolism*; D057230:Limit of Detection; D019098:Telomerase / Q000378:metabolism*; D016615:Telomere
chemical_list: D000814:Aniline Compounds; C416807:polyaniline; D006427:Hemin; D019098:Telomerase