title: EARLY ASSESSMENT AND PREDICTION OF POTENTIAL IMPACT OF THE IMPLANTATION OF POLYURETHANE SCAFFOLD IN PARTIAL MENISCAL LESIONS: A PILOT HORIZON SCANNING ACTIVITY IN SOUTH KOREA.
abstract: OBJECTIVE
  The aim of this study was to predict the potential impact of the introduction of implantation of polyurethane scaffold for the treatment of partial meniscal lesions in the South Korean healthcare system.
  
  
  METHODS
  The horizon scanning process was used to select a target technology and assess its potential impacts on patients and the Korean healthcare system. We identified and filtered research-phase health technologies that are not listed yet in Korean, but appear promising. After a process of prioritization, we chose the implantation of polyurethane scaffolds as a target technology. Then, through the procedures of assessment and peer review, we analyzed current evidence and its predicted potential impacts.
  
  
  RESULTS
  There were eight studies included in the review: one prospective cohort and seven case-series studies. Six revealed significant improvements in function and pain relief. Of the six studies, which reported safety endpoints, four stated no major postoperative complications related to scaffold, and two reported adverse events and serious adverse events such as pain, joint swelling, et cetera. We also included the potential impact of this technology based on the experts' consultation. They all agreed that it would satisfy the diverse needs of patients and fulfill clinical needs. However, the majority of related clinical studies were based on short-term follow-up observations without any validation process involving comparison with control groups.
  
  
  CONCLUSIONS
  Through a horizon scanning activity, we found that the implantation of polyurethane scaffolds is a promising technology to resolve articular cartilage defects; however, long-term evidence with comparison groups for safety and effectiveness is required.
authors.affiliation: Department of Horizon Scanning for Innovative Global Health Technology,National Evidence-Based Healthcare Collaborating Agency (NECA).
authors.forename: Ji Yun
authors.initials: JY
authors.lastname: Tark
authors.affiliation: Division for New Health Technology Assessment,National Evidence-Based Healthcare Collaborating Agency (NECA).
authors.forename: Ji-young
authors.initials: JY
authors.lastname: Jeong
authors.affiliation: Division for New Health Technology Assessment,National Evidence-Based Healthcare Collaborating Agency (NECA).
authors.forename: Min
authors.initials: M
authors.lastname: Lee
authors.affiliation: Department of Horizon Scanning for Innovative Global Health Technology,National Evidence-Based Healthcare Collaborating Agency (NECA).
authors.forename: Eunjung
authors.initials: E
authors.lastname: Park
authors.affiliation: Department of Horizon Scanning for Innovative Global Health Technology,National Evidence-Based Healthcare Collaborating Agency (NECA).
authors.forename: Jooyeon
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Horizon Scanning for Innovative Global Health Technology,National Evidence-Based Healthcare Collaborating Agency (NECA).
authors.forename: Ji Jeong
authors.initials: JJ
authors.lastname: Park
authors.affiliation: Department of Horizon Scanning for Innovative Global Health Technology,National Evidence-Based Healthcare Collaborating Agency (NECA).
authors.forename: Sungkyu
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Horizon Scanning for Innovative Global Health Technology,National Evidence-Based Healthcare Collaborating Agency (NECA)blu0924@neca.re.kr.
authors.forename: Chaemin
authors.initials: C
authors.lastname: Shin
mesh_terms: D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D011140:Polyurethanes; D019736:Prostheses and Implants; D056910:Republic of Korea; D013673:Technology Assessment, Biomedical / Q000379:methods*; D000070600:Tibial Meniscus Injuries / Q000601:surgery*
chemical_list: D011140:Polyurethanes
keywords: Emerging health technology; Horizon scanning; Polyurethane meniscal scaffold; Potential impact