title: Assessment of PSA-Age volume score in predicting positive prostate biopsy findings in Turkey.
abstract: OBJECTIVE
  To evaluate PSA-age volume (AV) scores in predicting positive prostate biopsy findings in Turkey.
  
  
  METHODS
  PSA-AV was calculated by multiplying the patient's age by the prostate volume and dividing it by the PSA level. Sensitivities and specificities of the PSA-AV were assessed by retrospective analysis of findings from 4,717 prostate biopsies.
  
  
  RESULTS
  The population's average age was 63.71±7.63 years, the mean PSA level was 9.73±17.01ng/mL, the mean prostate volume was 44.46±23.88 cm3. Of the 4,717 prostate biopsies, 1,171 biopsy specimens (24.8%) were positive for prostate cancer. A PSA-AV score of 700 had a sensitivity and specificity of 95% and 15%, respectively. These values were similar to the sensitivity and specificity for a PSA cut-off of 4ng/mL (94% and 13%, respectively). Although the sensitivity of a PSA-AV cut-off of 700 in patients over 60 years was similar to the PSA cut-off of 4ng/mL and the age-adjusted PSA, in patients < 60 years, its sensitivity was higher. While the sensitivities of a PSA-AV cut-off of 700 in patients with low prostate volume was higher than a PSA cut-off of 4ng/mL, the sensitivities of both methods with moderate prostate volumes were similar.
  
  
  CONCLUSIONS
  Considering all the biopsies, the sensitivity and specificity of a PSA-AV of 700 for predicting positive biopsy findings were similar to a PSA of 4ng/mL. We suggest the PSA-AV cut-off of 700 should only be used in patients younger than 60 with low prostate volumes (< 20cm3).
authors.affiliation: Department of Urology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
authors.forename: Oktay
authors.initials: O
authors.lastname: Uçer
authors.affiliation: Department of Urology, Istanbul Teaching and Research Hospital, Istanbul, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Yücetas
authors.affiliation: Urology Clinic, Acipayam State Hospital, Denizli, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Çelen
authors.affiliation: Department of Urology, Istanbul Teaching and Research Hospital, Istanbul, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Toktas
authors.affiliation: Department of Urology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
authors.forename: Talha
authors.initials: T
authors.lastname: Müezzinoglu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001706:Biopsy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology*; D012015:Reference Standards; D012016:Reference Values; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014421:Turkey
chemical_list: D017430:Prostate-Specific Antigen