title: Quercetin conjugated silica particles as novel biofunctional hybrid materials for biological applications.
abstract: The aim of this work is to formulate biofunctional hybrid materials (HMs) with quercetin (QC) and silica particles (SiPs) by simple methods such as sol-gel and QC conjugation. Physicochemical characterization included particle size, zeta potential (ζ), FTIR and SEM imaging. Spherical particles with ca. 115 nm in diameter were produced, ζ and FTIR demonstrated that QC conjugation was successfully achieved. Electrochemical analyses performed by cyclic voltammetry (CV) suggested that potential binding sites between QC and SiPs may be at functional groups from A ring or C ring, affecting the transfer electron of resorcinol moiety. Iron chelating activity and lipid peroxidation assays showed that after conjugation to SiPs, QC decreased its metal chelating activity, but anti-radical properties is maintained. Our results demonstrated that our proposed method is simple and effective to obtain bio-functional HMs. Our findings prove to be useful in the design of protective approaches against lipid oxidation in food, pharmaceutical, and cosmetics fields.
authors.affiliation: Centro de Investigaciones y Estudios Avanzados (CINVESTAV) del Instituto Politécnico Nacional, unidad Querétaro, Querétaro, Mexico.
authors.forename: Hayde
authors.initials: H
authors.lastname: Vergara-Castañeda
authors.affiliation: Centro de Física Aplicada y Tecnología Avanzada (CFATA) de la Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro, Mexico.
authors.forename: Angel R
authors.initials: AR
authors.lastname: Hernandez-Martinez
authors.affiliation: Centro de Física Aplicada y Tecnología Avanzada (CFATA) de la Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro, Mexico.
authors.forename: Miriam
authors.initials: M
authors.lastname: Estevez
authors.affiliation: Departamento de Investigación y Posgrado en Alimentos, Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico.
authors.forename: Sandra
authors.initials: S
authors.lastname: Mendoza
authors.affiliation: Centro de Investigaciones y Estudios Avanzados (CINVESTAV) del Instituto Politécnico Nacional, unidad Querétaro, Querétaro, Mexico. Electronic address: gabriel.luna@cinvestav.mx.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Luna-Barcenas
authors.affiliation: Centro de Investigaciones y Estudios Avanzados (CINVESTAV) del Instituto Politécnico Nacional, unidad Querétaro, Querétaro, Mexico. Electronic address: hectorpool@gmail.com.
authors.forename: Héctor
authors.initials: H
authors.lastname: Pool
mesh_terms: D001665:Binding Sites; D001672:Biocompatible Materials / Q000737:chemistry*; D003358:Cosmetics / Q000737:chemistry; D055664:Electrochemical Techniques; D019649:Food Industry; D015394:Molecular Structure; D010316:Particle Size; D011794:Quercetin / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D003358:Cosmetics; D012822:Silicon Dioxide; D011794:Quercetin
keywords: Antioxidant properties; Conjugation; Hybrid materials; Quercetin; Silica particles