title: Susceptibility of KSHV-Infected PEL Cell Lines to the Human Complement System.
abstract: Pleural effusion lymphoma (PEL) is a rare B-cell lymphoma that has a very poor prognosis with a median survival time of around 6 months. PEL is caused by Kaposi's sarcoma-associated herpesvirus, and is often co-infected with the Epstein Barr virus. The complement system is fundamental in the innate immune system against pathogen invasion and tumor development. In the present study, we investigated the activation of the complement system in PEL cells using human serum complements. Interestingly, two widely used PEL cell lines, BCP-1 and BCBL-1, showed different susceptibility to the complement system, which may be due to CD46 expression on their cell membranes. Complement activation did not induce apoptosis but supported cell survival considerably. Our results demonstrated the susceptibility of PEL to the complement system and its underlying mechanisms, which would provide insight into understanding the pathogenesis of PEL.
authors.affiliation: Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon 84824, Republic of Korea.
authors.forename: Seung-Min
authors.initials: SM
authors.lastname: Yoo
authors.affiliation: Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon 84824, Republic of Korea.
authors.forename: Hyungtaek
authors.initials: H
authors.lastname: Jeon
authors.affiliation: Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon 84824, Republic of Korea.
authors.forename: Suhyuk
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon 84824, Republic of Korea.
authors.forename: Myung-Shin
authors.initials: MS
authors.lastname: Lee
mesh_terms: D002460:Cell Line; D003165:Complement System Proteins / Q000276:immunology*; D019288:Herpesvirus 8, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D008223:Lymphoma / Q000276:immunology* / Q000821:virology; D051916:Membrane Cofactor Protein / Q000276:immunology; D016066:Pleural Effusion, Malignant / Q000276:immunology* / Q000821:virology
chemical_list: D051916:Membrane Cofactor Protein; D003165:Complement System Proteins
keywords: Human herpesvirus-8; Kaposi's sarcoma-associated herpesvirus; complement system; pleural effusion lymphoma