title: Prevention of chemotherapy-induced ovarian damage.
abstract: Recent advances in our understanding of the mechanisms underlying the impact of cytotoxic drugs on the ovary have opened up new directions for the protection of the ovary from chemotherapy-induced damage. These advances have spurred the investigation of pharmacological agents to prevent ovarian damage at the time of treatment. Prevention of ovarian damage and follicle loss would provide significant advantages over existing fertility preservation techniques. This manuscript reviews new methods for the prevention of chemotherapy-induced ovarian damage, including agents that act on the PI3K/PTEN/Akt follicle activation pathway, apoptotic pathways, the vascular system, and other potential methods of reducing chemotherapy-induced ovotoxicity.
authors.affiliation: Center for Fertility Preservation, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Hadassa
authors.initials: H
authors.lastname: Roness
authors.affiliation: Center for Fertility Preservation, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Oren
authors.initials: O
authors.lastname: Kashi
authors.affiliation: Center for Fertility Preservation, Sheba Medical Center, Tel Hashomer, Israel. Electronic address: meirow@post.tau.ac.il.
authors.forename: Dror
authors.initials: D
authors.lastname: Meirow
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects; D019610:Cytoprotection; D015195:Drug Design; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D058990:Molecular Targeted Therapy; D006080:Ovarian Follicle / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D020011:Protective Agents / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D020011:Protective Agents
keywords: Fertility preservation; chemotherapy; follicle activation