title: Effects of Hyperoxia on Oxygen-Related Inflammation with a Focus on Obesity.
abstract: Several studies have shown a pathological oxygenation (hypoxia/hyperoxia) on the adipose tissue in obese subjects. Additionally, the excess of body weight is often accompanied by a state of chronic low-degree inflammation. The inflammation phenomenon is a complex biological response mounted by tissues to combat injurious stimuli in order to maintain cell homeostasis. Furthermore, it is believed that the abnormal oxygen partial pressure occurring in adipose tissue is involved in triggering inflammatory processes. In this context, oxygen is used in modern medicine as a treatment for several diseases with inflammatory components. Thus, hyperbaric oxygenation has demonstrated beneficial effects, apart from improving local tissue oxygenation, on promoting angiogenesis, wound healing, providing neuroprotection, facilitating glucose uptake, appetite, and others. Nevertheless, an excessive hyperoxia exposure can lead to deleterious effects such as oxidative stress, pulmonary edema, and maybe inflammation. Interestingly, some of these favorable outcomes occur under high and low oxygen concentrations. Hereby, we review a potential therapeutic approach to the management of obesity as well as the oxygen-related inflammation accompanying expanded adipose tissue, based on elevated oxygen concentrations. To conclude, we highlight at the end of this review some areas that need further clarification.
authors.affiliation: Centre for Nutrition Research, Department of Nutrition, Food Sciences and Physiology, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain ; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain ; Navarra's Health Research Institute (IDISNA), 31008 Pamplona, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: González-Muniesa
authors.affiliation: Centre for Nutrition Research, Department of Nutrition, Food Sciences and Physiology, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Garcia-Gerique
authors.affiliation: Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Libertador Bernardo O'Higgins 340, Santiago, Chile.
authors.forename: Pablo
authors.initials: P
authors.lastname: Quintero
authors.affiliation: Centre for Nutrition Research, Department of Nutrition, Food Sciences and Physiology, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
authors.forename: Suyen
authors.initials: S
authors.lastname: Arriaza
authors.affiliation: Centre for Nutrition Research, Department of Nutrition, Food Sciences and Physiology, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
authors.forename: Amaya
authors.initials: A
authors.lastname: Lopez-Pascual
authors.affiliation: Centre for Nutrition Research, Department of Nutrition, Food Sciences and Physiology, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain ; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain ; Navarra's Health Research Institute (IDISNA), 31008 Pamplona, Spain.
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Martinez
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D006801:Humans; D006931:Hyperbaric Oxygenation; D000860:Hypoxia; D007249:Inflammation; D009765:Obesity / Q000378:metabolism / Q000473:pathology*; D010100:Oxygen / Q000378:metabolism*
chemical_list: D016207:Cytokines; D010100:Oxygen