title: Gains and losses on the road to understanding Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause for dementia, which affects approximately 120 thousand people in Switzerland and 35 million worldwide. Aging is a major risk factor for developing AD and thus, as our societies are growing older, we face great challenges to find treatment strategies. The disease is characterised by loss of memory, deposition of extracellular amyloid plaques containing Aβ peptides and intraneuronal tangles of the tau protein. To date, there is no effective treatment and the cause of the disease is still debated. The Schweizerische Alzheimervereinigung states that we need "continuous manifold research" into all possible causes of AD to find a cure for this disease. Fitting this proposition, a recent publication by Xia et al. (2015) described a novel mouse model that for the first time reproduces cortical neuron death as observed in human AD cases. At the same time, this publication questions the major theory of AD pathogenesis and points towards different treatment avenues that should be followed to find a cure for AD.
authors.affiliation: Division of Psychiatry Research, University of Zurich.
authors.forename: Uwe
authors.initials: U
authors.lastname: Konietzko
mesh_terms: D000375:Aging; D000544:Alzheimer Disease / Q000453:epidemiology / Q000209:etiology*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009474:Neurons / Q000378:metabolism; D053763:Presenilins / Q000378:metabolism*; D013557:Switzerland / Q000453:epidemiology
chemical_list: D016564:Amyloid beta-Protein Precursor; D053763:Presenilins