title: Acute generalized exanthematous pustulosis associated with ranolazine.
abstract: Acute generalized exanthematous pustulosis (AGEP) is a potentially widespread, pustular, cutaneous eruption commonly associated with drug administration. We report a case of AGEP associated with the antianginal, anti-ischemic agent ranolazine. The patient, an 83-year-old man, had a validation score of 10 out of 12 in accordance with the EuroSCAR criteria (8-12 is considered definitive), although it may have been higher had blood work been performed prior to diagnosis and treatment. After ranolazine was discontinued and a course of tapered oral prednisone was prescribed, the rash resolved with subsequent desquamation.
authors.affiliation: Forefront Dermatology, Stevens Points, Wisconsin, USA.
authors.forename: Kurt
authors.initials: K
authors.lastname: Grelck
authors.affiliation: Columbia Hospital, West Palm Beach, Florida, USA.
authors.forename: Noelle
authors.initials: N
authors.lastname: Stewart
authors.affiliation: Dermpath Diagnostics, Pompano Beach, Florida, USA.
authors.forename: Les
authors.initials: L
authors.lastname: Rosen
authors.affiliation: Sukal Skin Institute, Boca Raton, Florida, USA.
authors.forename: Sean
authors.initials: S
authors.lastname: Sukal
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D000369:Aged, 80 and over; D002317:Cardiovascular Agents / Q000009:adverse effects*; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D000069458:Ranolazine / Q000009:adverse effects*
chemical_list: D002317:Cardiovascular Agents; D005938:Glucocorticoids; D000069458:Ranolazine; D011241:Prednisone