title: Genetic differences among ethnic groups.
abstract: BACKGROUND
  Many differences between different ethnic groups have been observed, such as skin color, eye color, height, susceptibility to some diseases, and response to certain drugs. However, the genetic bases of such differences have been under-investigated. Since the HapMap project, large-scale genotype data from Caucasian, African and Asian population samples have been available. The project found that these populations were located in different areas of the PCA (Principal Component Analysis) plot. However, as an unsupervised method, PCA does not measure the differences in each single nucleotide polymorphism (SNP) among populations.
  
  
  RESULTS
  We applied an advanced mutual information-based feature selection method to detect associations between SNP status and ethnic groups using the latest HapMap Phase 3 release version 3, which included more sub-populations. A total of 299 SNPs were identified, and they can accurately predicted the ethnicity of all HapMap populations. The 10-fold cross validation accuracy of the SMO (sequential minimal optimization) model on training dataset was 0.901, and the accuracy on independent test dataset was 0.895.
  
  
  CONCLUSIONS
  In-depth functional analysis of these SNPs and their nearby genes revealed the genetic bases of skin and eye color differences among populations.
authors.affiliation: Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, P. R. China. tohuangtao@126.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.affiliation: Sate Key Laboratory of Biotherapy, Sichuan University, Sichuan, 610041, P. R. China. shuyang1986@gmail.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shu
authors.affiliation: College of Life Science, Shanghai University, Shanghai, 200444, P. R. China. cai_yud@126.com.
authors.forename: Yu-Dong
authors.initials: YD
authors.lastname: Cai
mesh_terms: D019295:Computational Biology / Q000379:methods*; D005006:Ethnicity / Q000235:genetics*; D005127:Eye Color; D014644:Genetic Variation; D015894:Genome, Human; D060148:HapMap Project; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis; D012880:Skin Pigmentation / Q000235:genetics