title: Heart disease modelling adds a Notch to its belt.
abstract: The heart is a complex organ, consisting of multiple cell types that coordinately regulate blood flow. Reciprocal Notch pathway signalling in endocardial and myocardial cells is now shown to promote maturation of the ventricular chambers. These insights reveal mechanisms that, when disrupted, can lead to cardiomyopathies.
authors.affiliation: Roddenberry Center for Stem Cell Biology and Medicine, Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, California 94158, USA, and the Departments of Pediatrics and Biochemistry &Biophysics, University of California, San Francisco, 16th Street, San Francisco, California 94143, USA.
authors.forename: Casey A
authors.initials: CA
authors.lastname: Gifford
authors.affiliation: Roddenberry Center for Stem Cell Biology and Medicine, Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, California 94158, USA, and the Departments of Pediatrics and Biochemistry &Biophysics, University of California, San Francisco, 16th Street, San Francisco, California 94143, USA.
authors.forename: Deepak
authors.initials: D
authors.lastname: Srivastava
mesh_terms: D006352:Heart Ventricles / Q000378:metabolism*; D006801:Humans; D038081:Organogenesis / Q000502:physiology*; D051880:Receptors, Notch / Q000378:metabolism*
chemical_list: D051880:Receptors, Notch