title: Construction of brain atlases based on a multi-center MRI dataset of 2020 Chinese adults.
abstract: Despite the known morphological differences (e.g., brain shape and size) in the brains of populations of different origins (e.g., age and race), the Chinese brain atlas is less studied. In the current study, we developed a statistical brain atlas based on a multi-center high quality magnetic resonance imaging (MRI) dataset of 2020 Chinese adults (18-76 years old). We constructed 12 Chinese brain atlas from the age 20 year to the age 75 at a 5 years interval. New Chinese brain standard space, coordinates, and brain area labels were further defined. The new Chinese brain atlas was validated in brain registration and segmentation. It was found that, as contrast to the MNI152 template, the proposed Chinese atlas showed higher accuracy in hippocampus segmentation and relatively smaller shape deformations during registration. These results indicate that a population-specific time varying brain atlas may be more appropriate for studies involving Chinese populations.
authors.affiliation: Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.|Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China.|Key Laboratory for Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China.
authors.forename: Peipeng
authors.initials: P
authors.lastname: Liang
authors.affiliation: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR.
authors.forename: Lin
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.|Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China.|Key Laboratory for Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Chen
authors.affiliation: Research Center for Medical Image Computing, Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.|Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
authors.forename: Yishan
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.|Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China.|Key Laboratory for Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Research Center for Medical Image Computing, Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.|Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR.
authors.forename: Vincent C T
authors.initials: VC
authors.lastname: Mok
authors.affiliation: Research Center for Medical Image Computing, Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.|Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
authors.forename: Winnie C W
authors.initials: WC
authors.lastname: Chu
authors.affiliation: Research Center for Medical Image Computing, Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.|Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
authors.forename: Defeng
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.|Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China.|Key Laboratory for Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China.
authors.forename: Kuncheng
authors.initials: K
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D001921:Brain / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D002681:China; D016208:Databases, Factual; D005260:Female; D006801:Humans; D020407:Internet; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014584:User-Computer Interface; D055815:Young Adult