title: Controlled release of acetylsalicylic acid from polythiophene/carrageenan hydrogel via electrical stimulation.
abstract: Blends between polythiophene (PTh) and a carrageenan hydrogel were fabricated as the matrix for the electric field assisted drug release. The pristine carrageenan and the blend films were prepared by the solution casting using acetylsalicylic acid (ASA) as the anionic model drug and Mg(2+), Ca(2+), and Ba(2+) as the crosslinking agents. The ASA was released by the Fickian diffusion mechanism. The diffusion coefficient decreased with increasing crosslinking ratio or decreasing crosslinking ionic radii. The diffusion coefficients were greater with the applied electrical potentials by an order of magnitude relative to those without electric field. Moreover, the diffusion coefficients with PTh as the drug carrier were higher than those without PTh. Thus, the presence of the conductive polymer in the hydrogel blend coupled with applied electric field is shown here to drastically enhance the drug delivery rate.
authors.affiliation: Conductive and Electroactive Polymer Research Unit, The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Sanita
authors.initials: S
authors.lastname: Pairatwachapun
authors.affiliation: Conductive and Electroactive Polymer Research Unit, The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Nophawan
authors.initials: N
authors.lastname: Paradee
authors.affiliation: Conductive and Electroactive Polymer Research Unit, The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: anuvat.s@chula.ac.th.
authors.forename: Anuvat
authors.initials: A
authors.lastname: Sirivat
keywords: Acetylsalicylic acid; Carrageenan hydrogel; Diffusion coefficient; Electrically controlled release; Polythiophene