title: Direct C-H Alkenylation of Functionalized Pyrazoles.
abstract: We have developed inter- and intramolecular C-H alkenylation reactions of pyrazoles. The catalyst, derived from Pd(OAc)2 and pyridine, enabled the oxidative alkenylation of pyrazoles containing a variety of functional groups at the C4 position. Activated alkenes, including acrylate, acrylamide, and styrene derivatives, and enamides could be installed in this process. The sequential C-H alkenylation and cyclization reactions gave rise to fused bicyclic pyrazoles, providing a new strategy to annulate readily available pyrazole compounds.
authors.affiliation: Department of Chemistry and Chemistry Institute of Functional Materials, Pusan National University , Busan 46241, Republic of Korea.
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Han
authors.affiliation: Department of Chemistry and Chemistry Institute of Functional Materials, Pusan National University , Busan 46241, Republic of Korea.
authors.forename: Hyun Tae
authors.initials: HT
authors.lastname: Kim
authors.affiliation: Department of Chemistry and Chemistry Institute of Functional Materials, Pusan National University , Busan 46241, Republic of Korea.
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Joo