title: Systems Medicine: The Future of Medical Genomics, Healthcare, and Wellness.
abstract: Recent advances in genomics have led to the rapid and relatively inexpensive collection of patient molecular data including multiple types of omics data. The integration of these data with clinical measurements has the potential to impact on our understanding of the molecular basis of disease and on disease management. Systems medicine is an approach to understanding disease through an integration of large patient datasets. It offers the possibility for personalized strategies for healthcare through the development of a new taxonomy of disease. Advanced computing will be an important component in effectively implementing systems medicine. In this chapter we describe three computational challenges associated with systems medicine: disease subtype discovery using integrated datasets, obtaining a mechanistic understanding of disease, and the development of an informatics platform for the mining, analysis, and visualization of data emerging from translational medicine studies.
authors.affiliation: European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, 50 Avenue Tony Garnier, Lyon, 69007, France.
authors.forename: Mansoor
authors.initials: M
authors.lastname: Saqi
authors.affiliation: European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, 50 Avenue Tony Garnier, Lyon, 69007, France.
authors.forename: Johann
authors.initials: J
authors.lastname: Pellet
authors.affiliation: European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, 50 Avenue Tony Garnier, Lyon, 69007, France.
authors.forename: Irina
authors.initials: I
authors.lastname: Roznovat
authors.affiliation: European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, 50 Avenue Tony Garnier, Lyon, 69007, France.
authors.forename: Alexander
authors.initials: A
authors.lastname: Mazein
authors.affiliation: European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, 50 Avenue Tony Garnier, Lyon, 69007, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ballereau
authors.affiliation: European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, 50 Avenue Tony Garnier, Lyon, 69007, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: De Meulder
authors.affiliation: European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, 50 Avenue Tony Garnier, Lyon, 69007, France. cauffray@eisbm.org.|Université Claude Bernard, 3e étage plot 2, 50 Avenue Tony Garnier, Lyon, Cedex 07, 69366, France. cauffray@eisbm.org.
authors.forename: Charles
authors.initials: C
authors.lastname: Auffray
mesh_terms: D003695:Delivery of Health Care / Q000379:methods / Q000639:trends; D023281:Genomics / Q000379:methods / Q000639:trends; D006262:Health; D006801:Humans; D048088:Informatics / Q000379:methods / Q000639:trends; D008511:Medicine / Q000379:methods / Q000639:trends; D049490:Systems Biology / Q000379:methods / Q000639:trends; D057170:Translational Research, Biomedical
keywords: Disease subtyping; P4 medicine; Patient stratification; Systems medicine; Translational informatics