title: Antibiotic Coating of Hernia Meshes: The Next Step Toward Preventing Mesh Infection.
abstract: Mesh bacterial colonization/infection remains a critical issue in complex ventral hernia repair. Despite the recent emergence of biologic meshes, current strategies to prevent and treat mesh infection are largely ineffective, often leading to device failure and subsequent explantation along with the associated costs and effect on patient welfare. Unacceptably high rates of morbidity and hernia recurrence following mesh infection highlight the need for innovation in the area of hernia repair for the complex patient. One recent strategy to address such shortcomings is local antibiosis in the form of polymer coatings applied to the mesh itself. Current literature regarding the use of antibiotic-coated hernia mesh is limited but does illustrate the ability of these devices to inhibit bacterial growth and prevent mesh infection in both in vitro and in vivo studies. Although there is a paucity of literature regarding long-term clinical efficacy, this provides opportunity for further inquiry into a promising new development to combat mesh infective complications.
authors.affiliation: Department of Surgery, University Hospitals Case Medical Center, Cleveland, Ohio.
authors.forename: Arnab
authors.initials: A
authors.lastname: Majumder
authors.affiliation: Department of Surgery, Case Comprehensive Hernia Center, University Hospitals Case Medical Center, Cleveland, Ohio.
authors.forename: Ruel
authors.initials: R
authors.lastname: Neupane
authors.affiliation: Department of Surgery, Director, Case Comprehensive Hernia Center, University Hospitals Case Medical Center, Cleveland, Ohio.
authors.forename: Yuri W
authors.initials: YW
authors.lastname: Novitsky
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D020099:Coated Materials, Biocompatible / Q000008:administration & dosage / Q000627:therapeutic use; D004195:Disease Models, Animal; D059685:Herniorrhaphy / Q000379:methods*; D006801:Humans; D008422:Materials Testing; D013526:Surgical Mesh; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible