title: The Effect of Magnesium on Visual Evoked Potentials in L-NAME-Induced Hypertensive Rats.
abstract: In the literature, although there are many studies regarding complications of hypertension, information concerning its influence on visual evoked potentials (VEPs) is limited. This study aims to clarify the possible therapeutic effects of the preferential magnesium (Mg) treatment on VEPs in an experimental hypertension model. Rats were divided into four groups as follows: control, Mg treated (Mg), N(omega)-nitro-L-arginine methyl ester (L-NAME) hypertension, and L-NAME hypertension + Mg treated (L-NAME + Mg). Hypertension was induced by L-NAME which was given to rats orally over 6 weeks (25 mg/kg/day in drinking water). A magnesium-enriched diet (0.8 g/kg) was given to treatment groups for 6 weeks. Systolic blood pressure (SBP) was determined by using the tail-cuff method. Flash VEPs were recorded. Our results revealed that the SBP was significantly increased in the L-NAME group compared to control. Magnesium treatment significantly attenuated SBP in the hypertensive rats compared to the L-NAME group. The mean latencies of P1, N1, P2, N2, and P3 components were significantly prolonged in hypertensive rats compared to control. Treatment with Mg provided a significant decrease in the latencies of P1, N1, P2, N2, and P3 potentials in the L-NAME + Mg group compared to the L-NAME group. Plasma Mg levels were increased in the L-NAME + Mg group compared to the L-NAME group. No change was detected in the Mg levels of the brains in all experimental groups. Magnesium treatment had no effect on the brain nitrate/nitrite and thiobarbituric acid-reactive substances (TBARS) levels in hypertensive rats compared to non-treated rats. There was a positive correlation between the brain TBARS levels and SBP of the rats. The present study suggests that Mg supplementation has the potential to prevent VEP changes in the L-NAME-induced hypertension model.
authors.affiliation: Faculty of Medicine, Department of Physiology, Akdeniz University, Arapsuyu, 07070, Antalya, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Ozsoy
authors.affiliation: Faculty of Medicine, Department of Physiology, Akdeniz University, Arapsuyu, 07070, Antalya, Turkey.
authors.forename: Sinem
authors.initials: S
authors.lastname: Aras
authors.affiliation: Faculty of Medicine, Department of Physiology, Akdeniz University, Arapsuyu, 07070, Antalya, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Ulker Karadamar
authors.affiliation: Faculty of Medicine, Department of Physiology, Akdeniz University, Arapsuyu, 07070, Antalya, Turkey.
authors.forename: Seher
authors.initials: S
authors.lastname: Nasircilar Ulker
authors.affiliation: Faculty of Medicine, Department of Physiology, Near East University, Nicosia, Turkish Republic of Northern Cyprus, Turkey.
authors.forename: Gunnur
authors.initials: G
authors.lastname: Kocer
authors.affiliation: Faculty of Medicine, Department of Physiology, Akdeniz University, Arapsuyu, 07070, Antalya, Turkey.
authors.forename: Umit Kemal
authors.initials: UK
authors.lastname: Senturk
authors.affiliation: Faculty of Medicine, Department of Physiology, Akdeniz University, Arapsuyu, 07070, Antalya, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Basrali
authors.affiliation: Faculty of Medicine, Department of Biophysics, Akdeniz University, Antalya, Turkey.
authors.forename: Piraye
authors.initials: P
authors.lastname: Yargicoglu
authors.affiliation: Faculty of Science and Letters, Department of Chemistry, Istanbul Technical University, Istanbul, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Ozyurt
authors.affiliation: Faculty of Medicine, Department of Physiology, Akdeniz University, Arapsuyu, 07070, Antalya, Turkey. ayagar@akdeniz.edu.tr.
authors.forename: Aysel
authors.initials: A
authors.lastname: Agar
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D006973:Hypertension / Q000139:chemically induced* / Q000517:prevention & control*; D008274:Magnesium / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D017392:Thiobarbituric Acid Reactive Substances; D008274:Magnesium; D019331:NG-Nitroarginine Methyl Ester
keywords: Hypertension; L-NAME; Magnesium; Nitric oxide; TBARS; VEP