title: Identifying rhesus macaque gene orthologs using heterospecific human CNV probes.
abstract: We used the Affymetrix(®) Genome-Wide Human SNP Array 6.0 to identify heterospecific markers and compare copy number and structural genomic variation between humans and rhesus macaques. Over 200,000 human copy number variation (CNV) probes were mapped to a Chinese and an Indian rhesus macaque sample. Observed genomic rearrangements and synteny were in agreement with the results of a previously published genomic comparison between humans and rhesus macaques. Comparisons between each of the two rhesus macaques and humans yielded 206 regions with copy numbers that differed by at least two fold in the Indian rhesus macaque and human, 32 in the Chinese rhesus macaque and human, and 147 in both rhesus macaques. The detailed genomic map and preliminary CNV data are useful for better understanding genetic variation in rhesus macaques, identifying derived changes in human CNVs that may have evolved by selection, and determining the suitability of rhesus macaques as human models for particular biomedical studies.
authors.affiliation: Molecular Anthropology Laboratory, Department of Anthropology, University of California, Davis, CA, USA.
authors.forename: Jillian
authors.initials: J
authors.lastname: Ng
authors.affiliation: Genome Center Bioinformatics Core, University of California, Davis, CA, USA.
authors.forename: Joseph N
authors.initials: JN
authors.lastname: Fass
authors.affiliation: Genome Center Bioinformatics Core, University of California, Davis, CA, USA.
authors.forename: Blythe
authors.initials: B
authors.lastname: Durbin-Johnson
authors.affiliation: Molecular Anthropology Laboratory, Department of Anthropology, University of California, Davis, CA, USA ; California National Primate Research Center, University of California, Davis, CA, USA.
authors.forename: David Glenn
authors.initials: DG
authors.lastname: Smith
authors.affiliation: California National Primate Research Center, University of California, Davis, CA, USA ; School of Mathematics and Natural Sciences, Arizona State University (ASU) at the West Campus, Glendale, AZ, USA.
authors.forename: Sree
authors.initials: S
authors.lastname: Kanthaswamy
keywords: Copy number variation (CNV); Heterospecific sequence map; Homo sapiens; Macaca mulatta