title: "Mouse Clone Model" for evaluating the immunogenicity and tumorigenicity of pluripotent stem cells.
abstract: To investigate the immune-rejection and tumor-formation potentials of induced pluripotent stem cells and other stem cells, we devised a model-designated the "Mouse Clone Model"-which combined the theory of somatic animal cloning, tetraploid complementation, and induced pluripotent stem cells to demonstrate the applicability of stem cells for transplantation therapy.
authors.affiliation: Department of Cell & Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, M5S 3G5, Canada. gang.zhang@utoronto.ca.|Department of Medicine, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Avenue, 4th Floor - 4KD481, Toronto, Ontario, M5T 2S8, Canada. gang.zhang@utoronto.ca.|Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Harvard University, 149 13th Street, Charlestown, MA, 02129, USA. gang.zhang@utoronto.ca.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Program in Life Science, New College, University of Toronto, 40 Willcocks Street, Toronto, Ontario, M5S 1C6, Canada. yizhang.zhang@mail.utoronto.ca.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019976:Cloning, Organism; D053595:Embryonic Stem Cells / Q000166:cytology / Q000276:immunology / Q000637:transplantation; D005816:Genetic Complementation Test; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000276:immunology* / Q000637:transplantation*; D051379:Mice; D023421:Models, Animal; D018448:Models, Immunological; D009374:Neoplasms, Experimental / Q000209:etiology; D044968:Regenerative Medicine; D033581:Stem Cell Transplantation / Q000009:adverse effects; D057891:Tetraploidy