title: A specific prediction equation is necessary to estimate peak oxygen uptake in obese patients with metabolic syndrome.
abstract: OBJECTIVE
  The aims were to: (1) compare peak oxygen uptake ([Formula: see text]peak) predicted from four standard equations to actual [Formula: see text]peak measured from a cardiopulmonary exercise test (CPET) in obese patients with metabolic syndrome (MetS), and (2) develop a new equation to accurately estimate [Formula: see text]peak in obese women with MetS.
  
  
  METHODS
  Seventy-five obese patients with MetS performed a CPET. Anthropometric data were also collected for each participant. [Formula: see text]peak was predicted from four prediction equations (from Riddle et al., Hansen et al., Wasserman et al. or Gläser et al.) and then compared with the actual [Formula: see text]peak measured during the CPET. The accuracy of the predictions was determined with the Bland-Altman method. When accuracy was low, a new prediction equation including anthropometric variables was proposed.
  
  
  RESULTS
  [Formula: see text]peak predicted from the equation of Wasserman et al. was not significantly different from actual [Formula: see text]peak in women. Moreover, a significant correlation was found between the predicted and actual values (p < 0.001, r = 0.69). In men, no significant difference was noted between actual [Formula: see text]peak and [Formula: see text]peak predicted from the prediction equation of Gläser et al., and these two values were also correlated (p = 0.03, r = 0.44). However, the LoA95% was wide, whatever the prediction equation or gender. Regression analysis suggested a new prediction equation derived from age and height for obese women with MetS.
  
  
  CONCLUSIONS
  The methods of Wasserman et al. and Gläser et al. are valid to predict [Formula: see text]peak in obese women and men with MetS, respectively. However, the accuracy of the predictions was low for both methods. Consequently, a new prediction equation including age and height was developed for obese women with MetS. However, new prediction equation remains to develop in obese men with MetS.
authors.affiliation: Service de Physiologie Digestive, Urinaire, Respiratoire Et Sportive, CHU Rouen, 76000, Rouen, France. david.debeaumont@chu-rouen.fr.|Pavillon de Pneumologie, La Clairière, CHU Bois-Guillaume, 76031, Rouen Cedex, France. david.debeaumont@chu-rouen.fr.
authors.forename: D
authors.initials: D
authors.lastname: Debeaumont
authors.affiliation: Service de Physiologie Digestive, Urinaire, Respiratoire Et Sportive, CHU Rouen, 76000, Rouen, France.|UPRES EA 3830, GRHV, 76000, Rouen, France.
authors.forename: C
authors.initials: C
authors.lastname: Tardif
authors.affiliation: Service de Nutrition, CHU Rouen, 76000, Rouen, France.
authors.forename: V
authors.initials: V
authors.lastname: Folope
authors.affiliation: UFR STAPS, Université de Rouen, 76000, Rouen, France.|EA 3832, CETAPS, 76 821, Mont Saint Aignan, France.
authors.forename: I
authors.initials: I
authors.lastname: Castres
authors.affiliation: UFR STAPS, Université de Rouen, 76000, Rouen, France.|EA 3832, CETAPS, 76 821, Mont Saint Aignan, France.
authors.forename: F
authors.initials: F
authors.lastname: Lemaitre
authors.affiliation: UFR STAPS, Université de Rouen, 76000, Rouen, France.|EA 3832, CETAPS, 76 821, Mont Saint Aignan, France.
authors.forename: C
authors.initials: C
authors.lastname: Tourny
authors.affiliation: Service de Nutrition, CHU Rouen, 76000, Rouen, France.|INSERM U1073, CHU Rouen, 76000, Rouen, France.
authors.forename: P
authors.initials: P
authors.lastname: Dechelotte
authors.affiliation: Unité de Biostatistiques, CHU Rouen, 76000, Rouen, France.
authors.forename: C
authors.initials: C
authors.lastname: Thill
authors.affiliation: Service de Pneumologie et Soins Intensifs Respiratoires, CHU Rouen, UPRES EA 3830, Université de Rouen, 76000, Rouen, France.
authors.forename: A
authors.initials: A
authors.lastname: Darmon
authors.affiliation: UFR STAPS, Université de Rouen, 76000, Rouen, France.|EA 3832, CETAPS, 76 821, Mont Saint Aignan, France.
authors.forename: J B
authors.initials: JB
authors.lastname: Coquart
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D015415:Biomarkers / Q000032:analysis*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology* / Q000503:physiopathology*; D008875:Middle Aged; D008962:Models, Theoretical; D009765:Obesity / Q000150:complications*; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D012044:Regression Analysis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D010100:Oxygen
keywords: Aerobic fitness; Cardiorespiratory fitness; Cycle ergometer; Maximal oxygen consumption; Obesity