title: [Analyses of clinical features and efficacy of sudden deafness with vertigo and dizziness].
abstract: OBJECTIVE
  To investigate the clinical characteristics and the effect of drug treatment for sudden hearing loss with vertigo or dizziness.
  
  
  METHODS
  In a prospective, randomized, single blinded randomized multicenter clinical study, patients with sudden deafness, ranging in age from 18 to 65 years old, with a duration less than 2 weeks, and with no any medical treatments were collected. In accordance with the hearing curve, those patients were divided into four types, i.e., low and intermediate frequency descent type; high frequency descent type; fall flat type; and total deafness type. Each type was treated by four different treatment options, according to the unified design of the random table, and randomly selected one of the options for treatment. The efficacy of the patients with sudden deafness with vertigo and dizziness was analyzed statistically after the follow-up for 4 weeks. SPSS 13.0 software was used to analyze the data.
  
  
  RESULTS
  In August 2007 to October 2011, 33 hospitals in the country included 1 024 patients with sudden deafness in line with the inclusion criteria, of whom 296 (28.91%) were accompanied by vertigo/dizziness symptoms, 126 were males and 170 were females, with an average age of (41.2 ± 13.5) years old. types of the different audiometric curves of sudden deafness, the occurrence of complete deafness with vertigo/dizziness was the highest (44.93%), followed by flat down type (25.87%), high frequency descent type (21.28%) and low intermediate frequency descent type (18.54%). After the standard treatment, the vertigo and dizziness symptoms of the sudden deafness patients could disappear, and the hearing in each group was obviously improved. The hearing curative effect on patients accompanied by vertigo/dizziness of low frequency and intermediate frequency descent type was the best, and the total efficiency can reach up to 94.74%, with the cure rate of 68.42%; followed by flat type, in which the total effective rate was 80.76%, with the recovery rate of 22.12%; and the effects on patients in high frequency descent type and total deafness type effect were relatively poor, in which the total effective rates were 70.00% (recovery rate of 10.00%) and 65.32% (recovery rate of 5.65%), respectively. The total effective rate of patients with sudden deafness associated with halo had no statistical significance (P > 0.05), in comparison to that of patients without halo; but, the cure rate of patients with no vertigo/dizziness of total deafness and the high frequency decreased patients with sudden deafness was significantly higher than that of vertigo/dizziness patients, with a statistical difference (P < 0.05).
  
  
  CONCLUSIONS
  The patients with sudden deafness in each type have a certain proportion of vertigo/dizziness, especially the deaf type. The possibility of hearing complete recovery in patients with vertigo/dizziness was significantly lower than that without vertigo/dizziness.
authors.affiliation: Center of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, The First Hospital of China Medical University, Shenyang 110001, China; Email: handm@trhos.com.
authors.forename: Demin
authors.initials: D
authors.lastname: Han
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Li
authors.forename: Shusheng
authors.initials: S
authors.lastname: Gong
authors.forename: Xiuwu
authors.initials: X
authors.lastname: Chen
authors.forename: Xixi
authors.initials: X
authors.lastname: Meng
authors.forename: Junxiang
authors.initials: J
authors.lastname: Tang
authors.forename: Jie
authors.initials: J
authors.lastname: Xiang
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, The First Hospital of China Medical University, Shenyang 110001, China; Email: djiangxj@163.com.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Jiang
authors.forename: Ning
authors.initials: N
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
authors.forename: Lian
authors.initials: L
authors.lastname: Hui
authors.forename: Shuai
authors.initials: S
authors.lastname: Feng
mesh_terms: D000328:Adult; D001299:Audiometry; D004244:Dizziness / Q000150:complications / Q000628:therapy*; D005260:Female; D003639:Hearing Loss, Sudden / Q000150:complications / Q000628:therapy*; D006320:Hearing Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016037:Single-Blind Method; D012984:Software; D014717:Vertigo / Q000150:complications / Q000628:therapy*