title: Association of human leukocyte antigen DRB1 polymorphism and tuberculosis: a meta-analysis.
abstract: OBJECTIVE
  To determine whether the human leukocyte antigen DRB1 (HLA-DRB1) is associated with clinical tuberculosis (TB).
  
  
  METHODS
  Pooled odds ratios (OR) with 95% confidence intervals (CIs) were used to evaluate the strength of the association between HLA-DRB1 alleles and risk of TB. The χ(2)-based Q-test and I(2) statistics were calculated to examine heterogeneity. Egger's test was performed for the assessment of publication bias. Subgroup analysis was performed based on ethnicity and genotyping methods.
  
  
  RESULTS
  A total of 19 case-control studies with 16 alleles (HLA-DRB1*01-HLA-DRB1*16) were included in this meta-analysis. No significant publication bias was detected among these studies. The HLA-DRB1*03 (OR 0.77, 95%CI 0.64-0.93, P = 0.0057) showed a protective effect, while HLA-DRB1*04 (OR 1.24, 95%CI 1.00-1.55, P = 0.0494), HLA-DRB1*08 (OR 1.45, 95%CI 1.14-1.86, P = 0.0030) and HLA-DRB1*16 (OR 1.39, 95%CI 1.04-1.87, P = 0.0269) were significantly associated with increased TB occurrence. Subgroup analysis showed that both ethnicity and genotyping method affected the association between HLA-DRB1*03, HLA-DRB1*04 and HLA-DRB1*08 alleles and TB occurrence.
  
  
  CONCLUSIONS
  These results reinforce the importance of HLA-DRB1 alleles in the development of infectious diseases.
authors.affiliation: Second Department of Orthopedics, Second Affiliated Hospital of Xi'an Jiaotong University Medical School, Shaanxi, China.
authors.forename: P-L
authors.initials: PL
authors.lastname: Yang
authors.affiliation: Second Department of Orthopedics, Second Affiliated Hospital of Xi'an Jiaotong University Medical School, Shaanxi, China.
authors.forename: X-J
authors.initials: XJ
authors.lastname: He
authors.affiliation: Second Department of Orthopedics, Second Affiliated Hospital of Xi'an Jiaotong University Medical School, Shaanxi, China.
authors.forename: Q-J
authors.initials: QJ
authors.lastname: Zang
authors.affiliation: Second Department of Orthopedics, Second Affiliated Hospital of Xi'an Jiaotong University Medical School, Shaanxi, China.
authors.forename: H-P
authors.initials: HP
authors.lastname: Li
authors.affiliation: Second Department of Orthopedics, Second Affiliated Hospital of Xi'an Jiaotong University Medical School, Shaanxi, China.
authors.forename: G-Y
authors.initials: GY
authors.lastname: Wang
authors.affiliation: Second Department of Orthopedics, Second Affiliated Hospital of Xi'an Jiaotong University Medical School, Shaanxi, China.
authors.forename: J
authors.initials: J
authors.lastname: Qin
mesh_terms: D020022:Genetic Predisposition to Disease; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: D059811:HLA-DRB1 Chains