title: Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers.
abstract: We report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinking agent. The concentration of detected testosterone varies from 0.05 ng/mL to 10 ng/mL. The detection limit reaches 48.7 pg/mL. Ultrahigh sensitivity, good specificity and reproducibility have been demonstrated, indicating the great potential of making a cost effective and easy to operate lab-on-Chip and down scaling micro-fluidics devices in biosensing.
authors.affiliation: State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China. chenyangqing@ioe-zju.org.
authors.forename: Yangqing
authors.initials: Y
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China. liuyong@ioe-zju.org.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China. 3110102785@zju.edu.cn.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Shen
authors.affiliation: CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China. changzm@sibet.ac.cn.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Chang
authors.affiliation: State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China. lhtang@zju.edu.cn.
authors.forename: Longhua
authors.initials: L
authors.lastname: Tang
authors.affiliation: CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China. wenfeidong@sibet.ac.cn.
authors.forename: Wen-Fei
authors.initials: WF
authors.lastname: Dong
authors.affiliation: State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China. limy@zju.edu.cn.
authors.forename: Mingyu
authors.initials: M
authors.lastname: Li
authors.affiliation: State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China. jjhe@zju.edu.cn.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: He
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D057230:Limit of Detection; D054802:Molecular Imprinting / Q000379:methods*; D015203:Reproducibility of Results; D013739:Testosterone / Q000032:analysis*
chemical_list: D013739:Testosterone
keywords: Microring resonator; Molecularly imprinted polymers; Testosterone