title: Inter-relations between osteoarthritis and metabolic syndrome: A common link?
abstract: Osteoarthritis (OA) is a degenerative disorder of the joint, principally occurring during aging, and characterized by a focal degradation of cartilage. It is the most prevalent rheumatic disease in industrialized countries and represents the second cause of disability in France. However, the etiology of OA remains unclear. There is only one cell type found in cartilage, chondrocyte, which is responsible for its repair and the synthesis of the elements of the extra-cellular matrix. A dysfunction of these cells results in an imbalance between repair and degradation in cartilage, leading to its destruction. Recently, a link between OA and metabolic syndrome (MetS) has been suggested, introducing a notion of metabolic OA, and a new vision of the disease. MetS is characterized by a cluster of factors (insulin resistance, hypertension, dyslipidemia, visceral obesity), although there is still no clear definition of it. During the 20th century, MetS dramatically increased with changes in population lifestyle, becoming a major health issue in industrialized countries. MetS concerns 10-30% of the worldwide population, but is prevalent in 59% of OA patients. Patients with both OA and MetS have more severe symptoms, occurring sooner than in the general population. Indeed, OA is generally a disease concerning the population over 65 years old, but with an associated MetS the target population is around 50 years old. In this review, we will focus on common factors in OA and MetS, such as hypertension, obesity, dyslipidemia, mitochondrial dysfunction and hyperglycemia, linking one disease to the other.
authors.affiliation: UMR-S 1124 INSERM Toxicologie, Pharmacologie et Signalisation Cellulaire, CUSP, Sorbonne Paris Cité, Université Paris Descartes, 75006 Paris, France; Unité pédagogique de Biochimie, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 4 avenue de l'Observatoire, 75006 Paris, France. Electronic address: solenn.le-clanche@parisdescartes.fr.
authors.forename: S
authors.initials: S
authors.lastname: Le Clanche
authors.affiliation: Unité pédagogique de Biochimie, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 4 avenue de l'Observatoire, 75006 Paris, France; UMR-S 1166 INSERM ICAN, Université Pierre et Marie Curie, Paris 6, 75013 Paris, France; Service de Biochimie Métabolique, Groupe hospitalier Pitié-Salpêtrière-Charles Foix, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris Cedex 13, France. Electronic address: dominique.rousselot@psl.aphp.fr.
authors.forename: D
authors.initials: D
authors.lastname: Bonnefont-Rousselot
authors.affiliation: Groupe de Recherche En Orthopédie de la Pitié-Salpêtrière (GREOPS), Hôpital de la Pitié-Salpêtrière, 47-83 boulevard de l'hôpital, 75013 Paris, France. Electronic address: elhadi.sariali@psl.aphp.fr.
authors.forename: E
authors.initials: E
authors.lastname: Sari-Ali
authors.affiliation: UMR-S 1124 INSERM Toxicologie, Pharmacologie et Signalisation Cellulaire, CUSP, Sorbonne Paris Cité, Université Paris Descartes, 75006 Paris, France; Service de rééducation, Hôpital Cochin (AP-HP), Université Paris Descartes, 27 rue du faubourg Saint Jacques, 75679 Paris Cedex 14, France. Electronic address: francois.rannou@cch.aphp.fr.
authors.forename: F
authors.initials: F
authors.lastname: Rannou
authors.affiliation: UMR-S 1124 INSERM Toxicologie, Pharmacologie et Signalisation Cellulaire, CUSP, Sorbonne Paris Cité, Université Paris Descartes, 75006 Paris, France; Unité pédagogique de Biochimie, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 4 avenue de l'Observatoire, 75006 Paris, France; Service de Diagnostic Biologique Automatisé, Hôpital Cochin (AP-HP), 27 rue du faubourg Saint Jacques, 75679 Paris Cedex 14, France. Electronic address: didier.borderie@cch.aphp.fr.
authors.forename: D
authors.initials: D
authors.lastname: Borderie
mesh_terms: D054392:Adipokines / Q000378:metabolism; D019902:Chondrocytes / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism; D024821:Metabolic Syndrome / Q000150:complications* / Q000378:metabolism*; D010003:Osteoarthritis / Q000150:complications* / Q000378:metabolism*
chemical_list: D054392:Adipokines
keywords: Dyslipidemia; Hyperglycemia; Metabolic syndrome; Mitochondrial dysfunction; Obesity; Osteoarthritis