title: The comparative pharmacokinetics of four bioactive ingredients after administration of Ramulus Cinnamomi-Radix Glycyrrhizae herb pair extract, Ramulus Cinnamomi extract and Radix Glycyrrhizae extract.
abstract: Ramulus Cinnamomi (RC)-Radix Glycyrrhizae (RG) is a classic herb pair, which is commonly used as a fixed form to treat cardiovascular disease in the clinic. Our work aimed to compare the pharmacokinetic difference of cinnamic acid, liquiritin, isoliquiritigenin and glycyrrhetinic acid in rats after oral administration of the RC-RG herb pair extracts [Guizhigancao Decoction (GGD) and Lingguizhugan Decoction (LGZGD)] and the single RC or RG extract. A HPLC-MS method was developed and validated to study comparative pharmacokinetics. The pharmacokinetic parameters (Cmax , AUC, MRT) of four compounds between the RC-RG herb pair group and the single herb (RC or RG) group showed significant differences (p < 0.05). Compared with the single herb (RC or RG) group, higher peak concentration, slower elimination and larger exposure could be observed after giving the RC-RG herb-pair extracts. The pharmacokinetic differences might indicate the relativity of remedy in the RC-RG herb pair and provide scientific information for rational administration of the drug in the clinic. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, no. 3, Shenyang, 110016, China.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, no. 3, Shenyang, 110016, China.
authors.forename: Lijiao
authors.initials: L
authors.lastname: Sun
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, no. 3, Shenyang, 110016, China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Gu
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, no. 3, Shenyang, 110016, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, no. 3, Shenyang, 110016, China.
authors.forename: Simin
authors.initials: S
authors.lastname: Zhao
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, no. 3, Shenyang, 110016, China.
authors.forename: Long-Shan
authors.initials: LS
authors.lastname: Zhao
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, no. 3, Shenyang, 110016, China.
authors.forename: Kai-Shun
authors.initials: KS
authors.lastname: Bi
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, no. 3, Shenyang, 110016, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Chen
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D010936:Plant Extracts / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; D010936:Plant Extracts
keywords: Radix Glycyrrhizae; Ramulus Cinnamomi; herb pair; pharmacokinetics