title: Macrocyclic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA.
abstract: The direct incorporation of macrocyclic cyclidene complexes into DNA via automated synthesis results in a new family of metal-functionalized DNA derivatives that readily demonstrate their utility through the ability of one redox-active copper(II)-containing strand to distinguish electrochemically between all four canonical DNA nucleobases at a single site within a target sequence of DNA.
authors.affiliation: School of Chemistry, University of Birmingham , Edgbaston, Birmingham, West Midlands B15 2TT, U.K.
authors.forename: Jean-Louis H A
authors.initials: JL
authors.lastname: Duprey
authors.affiliation: School of Chemistry, University of Birmingham , Edgbaston, Birmingham, West Midlands B15 2TT, U.K.
authors.forename: James
authors.initials: J
authors.lastname: Carr-Smith
authors.affiliation: School of Chemistry, University of Birmingham , Edgbaston, Birmingham, West Midlands B15 2TT, U.K.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Horswell
authors.affiliation: Insitute of Organic Chemistry, Polish Academy of Sciences , Kasprzaka 44/52, Warsaw, 01-224, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Kowalski
authors.affiliation: School of Chemistry, University of Birmingham , Edgbaston, Birmingham, West Midlands B15 2TT, U.K.
authors.forename: James H R
authors.initials: JH
authors.lastname: Tucker
mesh_terms: D004247:DNA / Q000737:chemistry*; D055664:Electrochemical Techniques; D047028:Macrocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D009711:Nucleotides / Q000032:analysis*; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D047028:Macrocyclic Compounds; D009711:Nucleotides; D009942:Organometallic Compounds; D004247:DNA