title: Polycystins: Mechanosensors with Diagnostic and Prognostic Potential in Cancer.
abstract: Polycystins are key regulators of cell-to-cell and cell-to-extracellular matrix (ECM) physical interactions that have been recently implicated in oncogenic mechanisms. Polycystins may be emerging as potential diagnostic and prognostic markers in specific types of malignancy, offering a promising research area for the development of novel biomarkers in solid tumors.
authors.affiliation: Department of Biological Chemistry, University of Athens Medical School, 11527 Athens, Greece.
authors.forename: Antonios N
authors.initials: AN
authors.lastname: Gargalionis
authors.affiliation: Department of Biological Chemistry, University of Athens Medical School, 11527 Athens, Greece.
authors.forename: Kostas A
authors.initials: KA
authors.lastname: Papavassiliou
authors.affiliation: Department of Biological Chemistry, University of Athens Medical School, 11527 Athens, Greece.
authors.forename: Efthimia K
authors.initials: EK
authors.lastname: Basdra
authors.affiliation: Department of Biological Chemistry, University of Athens Medical School, 11527 Athens, Greece. Electronic address: papavas@med.uoa.gr.
authors.forename: Athanasios G
authors.initials: AG
authors.lastname: Papavassiliou
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D040542:Mechanotransduction, Cellular; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D007690:Polycystic Kidney Diseases / Q000378:metabolism; D011379:Prognosis; D050396:TRPP Cation Channels / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D050396:TRPP Cation Channels
keywords: biomarker; cancer; mechanosensor; metastasis; polycystins; signal transduction