title: Hypersensitivity reaction associated with phenytoin.
abstract: Hypersensitivity reactions with antiepileptic drugs (AEDs) are generally associated with aromatic AEDs. We present a case of hypersensitivity reactions followed by administration of phenytoin with diazepam and ranitidine in a patient with generalized tonic-clonic seizures. Antigen-antibody reactions or decreased levels of epoxide hydrolase are well known with phenytoin. Increased level of serum phenytoin causing toxicities due to competitive inhibition with diazepam on co-administration was also reported in the literature. Prevention of the adverse effects with AEDs is a multi-stage process, which requires implementation of preventive measures through careful monitoring and prompts interventions.
authors.affiliation: Department of Pharmacy Practice, JSS College of Pharmacy (Affiliated to JSS University, Mysore, Karnataka, India), Ootacamund, Ooty, Tamil Nadu, India.
authors.forename: T H
authors.initials: TH
authors.lastname: Indu
authors.affiliation: Department of Pharmacy Practice, JSS College of Pharmacy (Affiliated to JSS University, Mysore, Karnataka, India), Ootacamund, Ooty, Tamil Nadu, India.
authors.forename: Roopa Satyanarayan
authors.initials: RS
authors.lastname: Basutkar
keywords: Antiepileptics; hypersensitivity reaction; phenytoin