title: Design, Synthesis, and Potential Antidepressant-like Activity of 7-prenyloxy-2,3-dihydroflavanone Derivatives.
abstract: A series of 7-prenyloxy-2, 3-dihydroflavanone derivatives were synthesized and screened for their antidepressant-like activity. Among them, it was observed that compounds 5j and 5k were found to be the most antidepressant-like activity. In addition, it was found that compounds 5j and 5k significantly increased the concentrations of the main neurotransmitters 5-HT and NE in the hippocampus, hypothalamus, and cortex. Compounds 5j and 5k also significantly increased the contents of 5-HIAA in the hippocampus and cortex, shut down 5-HT metabolism compared with mice treated with stress vehicle. These results suggested that compounds 5j and 5k displayed potent antidepressant-like properties that were mediated via neurochemical systems.
authors.affiliation: Food and Pharmacy College, Zhejiang Ocean University, Zhoushan, Zhejiang, 316022, China.|Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhoushan, Zhejiang, 316022, China.
authors.forename: Xing-Hua
authors.initials: XH
authors.lastname: Zhen
authors.affiliation: College of Medicine, Yanbian University, Park Street 977, Yanji, Jilin, 133002, China.
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Quan
authors.affiliation: Food and Pharmacy College, Zhejiang Ocean University, Zhoushan, Zhejiang, 316022, China.|Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhoushan, Zhejiang, 316022, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Peng
authors.affiliation: Zhejiang Ocean University Donghai Science and Technology College, Zhoushan, Zhejiang, 316000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Han
authors.affiliation: Zhejiang Ocean University Donghai Science and Technology College, Zhoushan, Zhejiang, 316000, China.
authors.forename: Zhou-Jun
authors.initials: ZJ
authors.lastname: Zheng
authors.affiliation: Food and Pharmacy College, Zhejiang Ocean University, Zhoushan, Zhejiang, 316022, China.|Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhoushan, Zhejiang, 316022, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Guan
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D015195:Drug Design; D005260:Female; D044950:Flavanones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D012701:Serotonin / Q000378:metabolism*
chemical_list: D000928:Antidepressive Agents; D044950:Flavanones; D012701:Serotonin
keywords: 7-Prenyloxy-2,3-dihydroflavanon; FST; TST; antidepressant activity; neurotransmitters