title: Essential Metals Zinc, Selenium, and Strontium Protect against Chromosome Damage Caused by Polycyclic Aromatic Hydrocarbons Exposure.
abstract: Essential metals play important roles in maintaining cellular homeostasis, but the effects of their interaction with the environmental pollutants are still not very well-known in human subjects. The aim of this study was to evaluate the roles of essential metals and their interactions with polycyclic aromatic hydrocarbons (PAHs) on chromosome damage, an early carcinogenic event. A total of 1245 male workers were included in this study and the levels of 11 urinary essential metals, 12 urinary PAH metabolites, plasma concentrations of benzo[a]pyrene-r-7,t-8,t-9,c-10-tetrahydotetrol-albumin (BPDE-Alb) adducts, and lymphocyte micronucleus (MN) frequencies were monitored. We found that zinc (Zn), selenium (Se), and strontium (Sr) have significant inverse dose-response relationships with MN frequencies (all P < 0.05). Furthermore, the protective roles of Zn, Se, and Sr were mainly shown among subjects with high levels of BPDE-Alb adducts. Significant effect modification of BPDE-Alb adducts on the associations of Zn, Se, and Sr with MN frequencies was observed (all Pinteraction < 0.05). Our study showed evidence that Zn, Se, and Sr play protective roles in reducing chromosome damage, and these effects can be modified by PAH exposure levels. These findings add potential evidence for the preventive effects of Zn, Se, and Sr against carcinogenesis in human subjects.
authors.affiliation: Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430074, China.
authors.forename: Yansen
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430074, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Feng
authors.affiliation: Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430074, China.
authors.forename: Suhan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430074, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Institute of Industrial Health, Wuhan Iron & Steel (Group) Corporation , Wuhan 430070, China.
authors.forename: Wangzhen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430074, China.
authors.forename: Meian
authors.initials: M
authors.lastname: He
authors.affiliation: Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430074, China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430074, China.
authors.forename: Tangchun
authors.initials: T
authors.lastname: Wu
authors.affiliation: Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430074, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Guo
mesh_terms: D000328:Adult; D001564:Benzo(a)pyrene; D002273:Carcinogens; D002875:Chromosomes; D004249:DNA Damage / Q000187:drug effects*; D004785:Environmental Pollutants; D006801:Humans; D008297:Male; D008670:Metals; D016273:Occupational Exposure / Q000032:analysis; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D012643:Selenium / Q000494:pharmacology*; D013324:Strontium / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology*
chemical_list: D002273:Carcinogens; D004785:Environmental Pollutants; D008670:Metals; D011084:Polycyclic Aromatic Hydrocarbons; D001564:Benzo(a)pyrene; D012643:Selenium; D015032:Zinc; D013324:Strontium