title: Modulation of meso-limbic reward processing by motivational tendencies in young adolescents and adults.
abstract: Adolescence is a particularly vulnerable period for the onset of substance use disorders and other psychopathology. Individual variability in motivational tendencies and temperament and significant changes in functional brain organization during adolescence are important factors to consider in the development of substance use and dependence. Recent conceptualizations suggest that sensitivity to reward is heightened in adolescence and that this motivation tendency may precipitate subsequent substance abuse. The present study examined the role of personality traits in mesolimbic neurobehavioral response on a monetary incentive delay (MID) task in young adolescents (11-14 years) and emerging adults (18-25 years) using functional magnetic resonance imaging. As a group, adolescents were not more sensitive to gains than losses compared to adults during either anticipatory and feedback phases; instead, compared to adults they showed less sensitivity to incentive magnitude in mesolimbic circuitry during anticipation and feedback stages. However, personality modulated this response such that adolescents high in impulsivity or low in avoidance tendencies showed greater gain sensitivity and adolescents high in avoidance showed greater loss sensitivity during cue anticipation. In adults, mesolimbic response was modulated by the impulsivity construct such that high-impulsive adults showed reduced magnitude sensitivity during both anticipation and feedback compared to low impulsive adults. The present findings suggest that impulsive personality significantly modulates mesolimbic reward response during both adolescence and adulthood but avoidance and approach tendencies also modulate this response in adolescents. Moreover, personality modulated incentive valence in adolescents but incentive magnitude in adults. Collectively, these findings suggest that mesolimbic reward circuitry function is modulated by somewhat different parameters in adolescence than in adulthood.
authors.affiliation: Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425-0616, USA. Electronic address: josep@musc.edu.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Joseph
authors.affiliation: Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425-0616, USA.
authors.forename: Xun
authors.initials: X
authors.lastname: Zhu
authors.affiliation: University of Kentucky, 410 Administration Drive, Lexington, KY 40508-0001, USA.
authors.forename: Donald
authors.initials: D
authors.lastname: Lynam
authors.affiliation: University of Kentucky, 410 Administration Drive, Lexington, KY 40508-0001, USA.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Kelly
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D002648:Child; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007175:Impulsive Behavior / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009042:Motivation / Q000502:physiology*; D012201:Reward; D055815:Young Adult
keywords: Brain development; FMRI; Monetary incentive delay; Reward