title: [Traditional Chinese medicine pairs (III)--effect of extract of Ginseng Radix et Rhizoma and Puerariae Lobatae Radix on intestinal absorption in rats].
abstract: This study focused on the intestinal absorption of traditional Chinese medicines (TCM) to reveal the scientific connotation of the compatibility of TCM pairs. The single pass intestinal perfusion (SPIP) was used in rats to compare the absorption of single extracts from Puerariae Lobatae Radix, single extracts from Ginseng Radix et Rhizoma, combined extracts from Puerariae Lobatae Radix and Ginseng Radix et Rhizoma and Puerariae Lobatae Radix and Ginseng Radix et Rhizoma mixture in rats. The content of puerarin, ginsenoside Rg1, ginsenoside Re and ginsenoside Rb1 in liquid were tested by HPLC. The speed constant (Ka) and apparent permeability coefficients (Papp) were calculated and compared. Specifically, the order of puerarin Ka and Papp values from high to low was Ginseng Radix et Rhizoma and Puerariae Lobatae Radix mixture > single extracts from Puerariae Lobatae Radix > combined extracts from Ginseng Radix et Rhizoma and Puerariae Lobatae Radix; the order of ginsenosides Ka and Papp values from high to low was Ginseng Radix et Rhizoma and Puerariae Lobatae Radix mixture > single extracts from Ginseng Radix et Rhizoma > combined extracts from Ginseng Radix et Rhizoma and Puerariae Lobatae Radix. The combined administration of Ginseng Radix et Rhizoma and Puerariae Lobatae Radix may improve the absorption in the intestinal tract.
authors.forename: Yi-hang
authors.initials: YH
authors.lastname: Chen
authors.forename: Meng-xuan
authors.initials: MX
authors.lastname: Li
authors.forename: Zhao-qing
authors.initials: ZQ
authors.lastname: Meng
authors.forename: Jiao-jiao
authors.initials: JJ
authors.lastname: Yang
authors.forename: Wen-zhe
authors.initials: WZ
authors.lastname: Huang
authors.forename: Zhen-zhong
authors.initials: ZZ
authors.lastname: Wang
authors.forename: Yue-sheng
authors.initials: YS
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
mesh_terms: D000818:Animals; D036145:Ginsenosides / Q000493:pharmacokinetics; D007408:Intestinal Absorption; D007529:Isoflavones / Q000493:pharmacokinetics; D008297:Male; D008516:Medicine, Chinese Traditional; D005894:Panax / Q000737:chemistry; D010936:Plant Extracts / Q000493:pharmacokinetics*; D029908:Pueraria / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome
chemical_list: D036145:Ginsenosides; D007529:Isoflavones; D010936:Plant Extracts; C049864:ginsenoside Re; C442759:ginsenoside Rb1; C035054:ginsenoside Rg1; C033607:puerarin