title: Tractography-based Parcellation of the Human Middle Temporal Gyrus.
abstract: The middle temporal gyrus (MTG) participates in a variety of functions, suggesting the existence of distinct functional subregions. In order to further delineate the functions of this brain area, we parcellated the MTG based on its distinct anatomical connectivity profiles and identified four distinct subregions, including the anterior (aMTG), middle (mMTG), posterior (pMTG), and sulcus (sMTG). Both the anatomical connectivity patterns and the resting-state functional connectivity patterns revealed distinct connectivity profiles for each subregion. The aMTG was primarily involved in the default mode network, sound recognition, and semantic retrieval. The mMTG was predominantly involved in the semantic memory and semantic control networks. The pMTG seems to be a part of the traditional sensory language area. The sMTG appears to be associated with decoding gaze direction and intelligible speech. Interestingly, the functional connectivity with Brodmann's Area (BA) 40, BA 44, and BA 45 gradually increased from the anterior to the posterior MTG, a finding which indicated functional topographical organization as well as implying that language processing is functionally segregated in the MTG. These proposed subdivisions of the MTG and its functions contribute to understanding the complex functions of the MTG at the subregional level.
authors.affiliation: Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.|Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 625014, China.
authors.forename: Jinping
authors.initials: J
authors.lastname: Xu
authors.affiliation: Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 625014, China.
authors.forename: Jiaojian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Lingzhong
authors.initials: L
authors.lastname: Fan
authors.affiliation: Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.|National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Li
authors.affiliation: Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 625014, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
authors.forename: Qingmao
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 625014, China.|Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.|National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.|CAS Center for Excellence in Brain Science, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.|The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
mesh_terms: D000465:Algorithms; D056324:Diffusion Tensor Imaging / Q000379:methods*; D006801:Humans; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology; D012146:Rest; D013702:Temporal Lobe / Q000033:anatomy & histology* / Q000502:physiology