title: Rapid microwave-assisted synthesis of molecularly imprinted polymers on carbon quantum dots for fluorescent sensing of tetracycline in milk.
abstract: In this paper, a novel, selective and eco-friendly sensor for the detection of tetracycline was developed by grafting imprinted polymers onto the surface of carbon quantum dots. A simple microwave-assisted approach was utilized to fabricate the fluorescent imprinted composites rapidly for the first time, which could shorten the polymerization time and simplify the experimental procedure dramatically. The novel composites not only demonstrated excellent fluorescence stability and special binding sites, but also could selectively accumulate target analytes. Under optimal conditions, the relative fluorescence intensity of the composites decreased linearly with increasing the concentration of tetracycline from 20 nM to 14 µM. The detection limit of tetracycline was 5.48 nM. The precision and reproducibility of the proposed sensor were also acceptable. Significantly, the practicality of this ultrasensitive sensor for tetracycline detection in milk was further validated, revealing the advantages of simplicity, sensitivity, selectivity and low cost. This approach combines the high selective adsorption property of molecular imprinted polymers and the sensitivity of fluorescence detection. It is envisioned that the development of fluorescent molecularly imprinted composites will offer a new way of thinking for rapid analysis in complex samples.
authors.affiliation: College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Hou
authors.affiliation: College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, PR China.
authors.forename: Huiyu
authors.initials: H
authors.lastname: Li
authors.affiliation: College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, PR China.
authors.forename: Long
authors.initials: L
authors.lastname: Wang
authors.affiliation: College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, PR China.
authors.forename: Tianyu
authors.initials: T
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ding
authors.affiliation: College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, PR China. Electronic address: dinglan@jlu.edu.cn.
authors.forename: Lan
authors.initials: L
authors.lastname: Ding
mesh_terms: D000818:Animals; D002138:Calibration; D002244:Carbon / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D004350:Drug Residues / Q000032:analysis / Q000737:chemistry; D007700:Kinetics; D057230:Limit of Detection; D008872:Microwaves; D008892:Milk / Q000737:chemistry*; D054802:Molecular Imprinting; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D045663:Quantum Dots / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000295:instrumentation*; D013752:Tetracycline / Q000032:analysis* / Q000737:chemistry
chemical_list: D011108:Polymers; D002244:Carbon; D013752:Tetracycline
keywords: Carbon quantum dots; Fluorescence detection; Microwave irradiation; Molecularly imprinted polymer; Tetracycline