title: Triterpene saponins with α-glucosidase inhibition and cytotoxic activity from the leaves of Schefflera sessiliflora.
abstract: From the leaves of Schefflera sessiliflora De P. V., two new triterpene saponins including one oleanane-type saponin, named scheffleraside C (1) and one lupane-type saponin scheffleraside D (2), together with six known triterpene saponins (3-8), were isolated by various chromatography methods. Among them, 3 was found for the first time from natural sources, while 6-8 were isolated for the first time from the genus Schefflera. Their structures were elucidated by IR, UV, HR-ESI-MS, NMR 1D and 2D experiments, and comparison of their NMR data with previously reported data. Their α-glucosidase inhibition and cytotoxic activity against MCF-7 human breast cancer cell lines were evaluated. The isolates (1, 3-5, 8) showed stronger α-glucosidase inhibitory activity (IC50 = 5.99-76.58 μM) than the standard drug acarbose (IC50 = 214.50 μM). At the concentration of 100 μg/ml, the isolates (1, 2) showed appreciable cytotoxic activity (67.92, 63.83%, respectively).
authors.affiliation: a Institute of Chemical Technology, Vietnam Academy of Science and Technology , Ho Chi Minh city , Viet Nam.
authors.forename: Tan Phat
authors.initials: TP
authors.lastname: Nguyen
authors.affiliation: a Institute of Chemical Technology, Vietnam Academy of Science and Technology , Ho Chi Minh city , Viet Nam.
authors.forename: Tien Dung
authors.initials: TD
authors.lastname: Le
authors.affiliation: a Institute of Chemical Technology, Vietnam Academy of Science and Technology , Ho Chi Minh city , Viet Nam.
authors.forename: Nhat Minh
authors.initials: NM
authors.lastname: Phan
authors.affiliation: a Institute of Chemical Technology, Vietnam Academy of Science and Technology , Ho Chi Minh city , Viet Nam.
authors.forename: Trong Dat
authors.initials: TD
authors.lastname: Bui
authors.affiliation: a Institute of Chemical Technology, Vietnam Academy of Science and Technology , Ho Chi Minh city , Viet Nam.
authors.forename: Dinh Tri
authors.initials: DT
authors.lastname: Mai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027481:Araliaceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D053978:Pentacyclic Triterpenes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D009828:Oleanolic Acid; D012503:Saponins; D014315:Triterpenes; C413246:oleanane; C480546:lupane; D053978:Pentacyclic Triterpenes
keywords: Araliaceae; Schefflera sessiliflora; cytotoxic activity; scheffleraside C; scheffleraside D; α-glucosidase inhibition