title: pH-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs.
abstract: Carboxymethyl-β-cyclodextrin (CMβ-CD)-modified glycol chitosan (GCS) nanoparticles (GCS-CMβ-CD NPs) were synthesized, and their pH-sensitive drug-release properties were investigated. GCS-CMβ-CD NPs could encapsulate doxorubicin hydrochloride (DOX), and the encapsulation efficiency and loading capacity increased with the amount of CMβ-CD. Drug-release studies indicate that DOX released was greater in acidic medium (pH 5.0) than in weakly basic medium (pH 7.4). The mechanism underlying the pH-sensitive properties of the carrier was analyzed. Finally, the MCF-7 (human breast cancer) and SW480 cell lines (human colon cancer) were used to evaluate the cytotoxicity of the NPs. The drug-loaded carriers show good inhibition of the growth of cancer cells compared with free DOX, and the carriers have good biocompatibility. In addition, the drug-loaded NPs have sustained drug-release properties. All these properties of the newly synthesized GCS-CMβ-CD NPs suggest a promising potential as an effective anticancer drug-delivery system for controlled drug release.
authors.affiliation: School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: Yiwen
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Qin
authors.affiliation: School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: Haina
authors.initials: H
authors.lastname: Tan
authors.affiliation: School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: Miao
authors.initials: M
authors.lastname: Jiang
authors.affiliation: School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: Mei
authors.initials: M
authors.lastname: Lu
authors.affiliation: School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D047392:beta-Cyclodextrins; C441457:carboxymethyl-beta-cyclodextrin; C118638:glycol-chitosan; D004317:Doxorubicin; D048271:Chitosan
keywords: MCF-7; SW480; cell viability; encapsulation efficiency; loading capacity; surface plasmon resonance