title: Stem cell-based therapies to promote angiogenesis in ischemic cardiovascular disease.
abstract: Stem cell therapy is a promising approach for the treatment of tissue ischemia associated with myocardial infarction and peripheral arterial disease. Stem and progenitor cells derived from bone marrow or from pluripotent stem cells have shown therapeutic benefit in boosting angiogenesis as well as restoring tissue function. Notably, adult stem and progenitor cells including mononuclear cells, endothelial progenitor cells, and mesenchymal stem cells have progressed into clinical trials and have shown positive benefits. In this review, we overview the major classes of stem and progenitor cells, including pluripotent stem cells, and summarize the state of the art in applying these cell types for treating myocardial infarction and peripheral arterial disease.
authors.affiliation: Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Stanford Cardiovascular Institute, Stanford University, Stanford, California; and.
authors.forename: Luqia
authors.initials: L
authors.lastname: Hou
authors.affiliation: Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Stanford Cardiovascular Institute, Stanford University, Stanford, California; and.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: Stanford Cardiovascular Institute, Stanford University, Stanford, California; and Department of Cardiothoracic Surgery, Stanford University, Stanford, California.
authors.forename: Y Joseph
authors.initials: YJ
authors.lastname: Woo
authors.affiliation: Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Stanford Cardiovascular Institute, Stanford University, Stanford, California; and Department of Cardiothoracic Surgery, Stanford University, Stanford, California ngantina@stanford.edu.
authors.forename: Ngan F
authors.initials: NF
authors.lastname: Huang
mesh_terms: D000818:Animals; D006801:Humans; D007511:Ischemia / Q000628:therapy*; D017202:Myocardial Ischemia / Q000628:therapy*; D018919:Neovascularization, Physiologic; D033581:Stem Cell Transplantation / Q000379:methods*
keywords: angiogenesis; hindlimb ischemia; myocardial infarction; peripheral arterial disease; pluripotent stem cell; stem cell therapy