title: Enhanced Bioconcentration of Bisphenol A in the Presence of Nano-TiO2 Can Lead to Adverse Reproductive Outcomes in Zebrafish.
abstract: Titanium dioxide nanoparticles (n-TiO2) and bisphenol A (BPA) are widespread environmental contaminants in the aquatic environment. We hypothesized that n-TiO2 may adsorb BPA, and thus modify its bioavailability and toxicity to aquatic organisms. In this study, the bioavailability and toxicity of BPA (0, 2, 20, 200 μg/L) was investigated in the presence of n-TiO2 (100 μg/L). The n-TiO2 sorbed BPA and the resulting nanoparticles were taken up by zebrafish, where they translocated to the liver, brain, and gonad tissues. Increased tissue burdens of both BPA and n-TiO2 were observed following coexposure, and they also caused a reduction in plasma concentrations of estradiol (E2), testosterone (T), follicle-stimulating hormone (FSH), and luteinizing hormone (LH). Plasma vitellogenin (VTG) concentrations were significantly increased in males and females upon exposure to BPA. Histological examination of the ovary and testes did not show obvious morphological alterations; however, inhibition of egg production was noted in the presence of n-TiO2. The results indicated that n-TiO2 acts as a carrier of BPA and enhances its bioconcentration in zebrafish, leading to endocrine disruption and impairment of reproduction.
authors.affiliation: State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan 430072, China.|Laboratory of Quality and Safety Risk Assessment for Citrus Products, Ministry of Agriculture, Institute of Citrus Research, Southwest University , Chongqing 400712, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Fang
authors.affiliation: State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan 430072, China.|Graduate University of Chinese Academy of Sciences , Beijing 100039, China.
authors.forename: Qipeng
authors.initials: Q
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan 430072, China.
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan 430072, China.|Graduate University of Chinese Academy of Sciences , Beijing 100039, China.
authors.forename: Jianghuan
authors.initials: J
authors.lastname: Hua
authors.affiliation: State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan 430072, China.|Graduate University of Chinese Academy of Sciences , Beijing 100039, China.
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan 430072, China.
authors.forename: Bingsheng
authors.initials: B
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000493:pharmacokinetics / Q000633:toxicity*; D001682:Biological Availability; D052244:Endocrine Disruptors / Q000493:pharmacokinetics / Q000633:toxicity; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D053758:Nanoparticles / Q000633:toxicity*; D010053:Ovary / Q000187:drug effects; D010636:Phenols / Q000493:pharmacokinetics / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects*; D013737:Testis / Q000187:drug effects; D013739:Testosterone / Q000097:blood; D014018:Tissue Distribution; D014025:Titanium / Q000493:pharmacokinetics / Q000633:toxicity*; D014819:Vitellogenins / Q000097:blood; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics / Q000633:toxicity*; D015027:Zebrafish / Q000502:physiology; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004958:Estradiol; D005640:Follicle Stimulating Hormone; D007986:Luteinizing Hormone; D010636:Phenols; D013739:Testosterone; D014025:Titanium; D014819:Vitellogenins; D014874:Water Pollutants, Chemical; C009495:titanium dioxide; C006780:bisphenol A; D000098826:Bisphenol A Compounds