title: Platelet mass index in very preterm infants: can it be used as a parameter for neonatal morbidities?
abstract: Platelet mass index (PMI) is related to the platelet functionality. The aim of this study was to evaluate the correlation between PMI and the occurrence of various inflammation-related morbidities of prematurity, such as bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), intraventricular hemorrhage (IVH) and sepsis in very low-birth weight (VLBW) infants.
  
  
  
  This retrospective analysis of VLBW infants admitted to a level 3 neonatal intensive care unit from October 2012 and 2014, n = 330. Platelet mass was calculated and recorded on the day of birth and between 3 and 7 days (second measure) for each patient. Statistical analysis included analysis of paired samples t test and independent samples t test.
  
  
  
  Among VLBW neonates, PMI values were lower in infants with ROP (p = 0.016), BPD (p = 0.002), IVH (p = 0.018) and NEC (p = 0.011) when compared with the control group in the second measurement.
  
  
  
  In this study, we found that premature infants with BPD, NEC, ROP, IVH and sepsis had lower PMI levels in early postnatal life than infants without these diseases. This might be associated with the inflammatory process.
authors.affiliation: a Division of Neonatology , Zekai Tahir Burak Maternity Teaching Hospital , Ankara , Turkey.
authors.forename: Nilufer
authors.initials: N
authors.lastname: Okur
authors.affiliation: a Division of Neonatology , Zekai Tahir Burak Maternity Teaching Hospital , Ankara , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Buyuktiryaki
authors.affiliation: a Division of Neonatology , Zekai Tahir Burak Maternity Teaching Hospital , Ankara , Turkey.
authors.forename: Nurdan
authors.initials: N
authors.lastname: Uras
authors.affiliation: a Division of Neonatology , Zekai Tahir Burak Maternity Teaching Hospital , Ankara , Turkey.
authors.forename: Mehmet Yekta
authors.initials: MY
authors.lastname: Oncel
authors.affiliation: a Division of Neonatology , Zekai Tahir Burak Maternity Teaching Hospital , Ankara , Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Ertekin
authors.affiliation: a Division of Neonatology , Zekai Tahir Burak Maternity Teaching Hospital , Ankara , Turkey.
authors.forename: Fuat Emre
authors.initials: FE
authors.lastname: Canpolat
authors.affiliation: a Division of Neonatology , Zekai Tahir Burak Maternity Teaching Hospital , Ankara , Turkey.
authors.forename: Serife Suna
authors.initials: SS
authors.lastname: Oguz
mesh_terms: D001792:Blood Platelets / Q000166:cytology*; D016022:Case-Control Studies; D005312:Fetal Blood / Q000166:cytology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D007235:Infant, Premature, Diseases / Q000097:blood* / Q000401:mortality; D019102:Infant, Very Low Birth Weight / Q000097:blood*; D010976:Platelet Count; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology
keywords: Mortality; neonatal; platelet mass index