title: Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer.
abstract: The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ovid, EBSCO, PubMed, CNKI, CBMDISC, VIP, and WanFang Data. The literature was screened based on inclusion and exclusion criteria. A meta-analysis was performed by calculating the combined odds ratios (OR) and 95% confidence intervals (CI) using the RevMan 5.0. A total of 7 case-control studies were selected, which included 1439 cases and 2927 control subjects. Meta-analysis showed that the rs4680 polymorphism was not associated with ovarian cancer [GG vs (GA+AA): OR = 1.02, 95%CI = 0.88-1.19; G vs A allele: OR = 1.0, 95%CI = 0.90-1.11]. We, therefore, conclude that the COMT rs4680 polymorphism is not associated with susceptibility to ovarian cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Huangshi Central Hospital of Hubei Province (Affiliated Hospital of Hubei Polytechnic University), Hubei Key laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi, China.
authors.forename: W
authors.initials: W
authors.lastname: Pan
authors.affiliation: Department of Pharmacy, Huangshi Central Hospital of Hubei Province (Affiliated Hospital of Hubei Polytechnic University), Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi, China.
authors.forename: H
authors.initials: H
authors.lastname: Liao
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias
chemical_list: D002394:Catechol O-Methyltransferase