title: Effects of ethanol consumption and alcohol detoxification on the biomechanics and morphology the bone in rat femurs.
abstract: The objective of this study was to verify the effects of ethanol consumption and alcohol detoxification on the biomechanics, area and thickness of cortical and trabecular bone in rat femur. This was an experimental study in which 18 male Wistar rats were used, with 40 days of age, weighing 179 ± 2.5 g. The rats were divided into three groups (n=06): CT (control), AC (chronic alcoholic), DT (detoxification). After experimental procedures, the animals were euthanized by an overdose of the anesthetic and their femurs were collected for mechanical testing and histological processing. All animals did not present malnutrition or dehydration during experimentation period. Morphometric analysis of cortical and trabecular bones in rat femurs demonstrated that AC animals showed inferior dimensions and alcohol detoxification (DT) allowed an enhancement in area and thickness of cortical and trabecular bone. Material and structural properties data of AC group highlighted the harmful effects of ethanol on bone mechanical properties. The results of this study demonstrated that chronic alcoholic rats (AC) presented major bone damage in all analyzed variables. Those findings suggested that alcohol detoxification is highly suggested in pre-operative planning and this corroborates to the success of bone surgery and bone tissue repair. Thanks to the financial support offered by PROBIC - UNIFENAS.
authors.affiliation: Faculdade de Medicina Veterinária, Universidade José do Rosário Vellano, Alfenas, MG, Brazil.
authors.forename: J A D
authors.initials: JA
authors.lastname: Garcia
authors.affiliation: Escola de Enfermagem, Universidade Federal de Alfenas, Alfenas, Brazil.
authors.forename: A L T
authors.initials: AL
authors.lastname: Souza
authors.affiliation: Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil.
authors.forename: L H C
authors.initials: LH
authors.lastname: Cruz
authors.affiliation: Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: P P
authors.initials: PP
authors.lastname: Marques
authors.affiliation: Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: J A
authors.initials: JA
authors.lastname: Camilli
authors.affiliation: Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: W R
authors.initials: WR
authors.lastname: Nakagaki
authors.affiliation: Instituto de Biociências, Universidade Federal de Alfenas, Alfenas, MG, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Esteves
authors.affiliation: Instituto de Biociências, Universidade Federal de Alfenas, Alfenas, MG, Brazil.
authors.forename: W C
authors.initials: WC
authors.lastname: Rossi-Junior
authors.affiliation: Instituto de Biociências, Universidade Federal de Alfenas, Alfenas, MG, Brazil.
authors.forename: G J M
authors.initials: GJ
authors.lastname: Fernandes
authors.affiliation: Instituto de Biociências, Universidade Federal de Alfenas, Alfenas, MG, Brazil.
authors.forename: F D
authors.initials: FD
authors.lastname: Guerra
authors.affiliation: Instituto de Biociências, Universidade Federal de Alfenas, Alfenas, MG, Brazil.
authors.forename: E A
authors.initials: EA
authors.lastname: Soares
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D000431:Ethanol / Q000493:pharmacokinetics / Q000494:pharmacology*; D005269:Femur / Q000187:drug effects*; D008658:Inactivation, Metabolic; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000431:Ethanol