title: The impact of green tea polyphenols on development and reproduction inDrosophila melanogaster.
abstract: Although, green tea has numerous health benefits, adverse effects with excessive consumption have been reported. UsingDrosophila melanogaster, a decrease in male fertility with green tea was evidenced. Here, the extent of green tea toxicity on development and reproduction was investigated.Drosophila melanogasterembryos and larvae were exposed to various doses of green tea polyphenols (GTP). Larvae exposed to 10 mg/mL GTP were slower to develop, emerged smaller, and exhibited a dramatic decline in the number of emerged offspring. GTP protected flies against desiccation but sensitized them to starvation and heat stress. Female offspring exhibited a decline in reproductive output and decreased survival while males were unaffected. GTP had a negative impact on reproductive organs in both males and females (e.g., atrophic testes in males, absence of mature eggs in females). Collectively, the data show that high doses of GTP adversely affect development and reproduction ofDrosophila melanogaster.
authors.affiliation: Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California, USA.
authors.forename: Terry E
authors.initials: TE
authors.lastname: Lopez
authors.affiliation: Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California, USA.
authors.forename: Hoang M
authors.initials: HM
authors.lastname: Pham
authors.affiliation: Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California, USA.
authors.forename: Julia
authors.initials: J
authors.lastname: Barbour
authors.affiliation: Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California, USA.
authors.forename: Phillip
authors.initials: P
authors.lastname: Tran
authors.affiliation: Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Van Nguyen
authors.affiliation: Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California, USA.
authors.forename: Sean P
authors.initials: SP
authors.lastname: Hogan
authors.affiliation: Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California, USA.
authors.forename: Richelle L
authors.initials: RL
authors.lastname: Homo
authors.affiliation: Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California, USA.
authors.forename: Volkan
authors.initials: V
authors.lastname: Coskun
authors.affiliation: Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California, USA.
authors.forename: Samuel E
authors.initials: SE
authors.lastname: Schriner
authors.affiliation: Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California, USA.
authors.forename: Mahtab
authors.initials: M
authors.lastname: Jafari
keywords: Drosophila; development; green tea; reproduction; toxicity