title: Ultrasound-assisted modulation of concomitant polymorphism of curcumin during liquid antisolvent precipitation.
abstract: Curcumin polymorphs were found to precipitate concomitantly during liquid antisolvent precipitation. While, commercially available curcumin exists in a monoclinic form, the curcumin particles when precipitated in presence of additives and ultrasound were either found to be the mixtures of orthorhombic (Form 3) and monoclinic form (Form 1) or were found to be in orthorhombic form (Form 3) or monoclinic form (Form 1). The experimentally observed particle morphologies did not match clearly with the predicted BFDH morphologies of curcumin and the experimentally observed morphologies were more elongated as compared to the predicted BFDH morphologies. At lower ultrasonic irradiation times, the monoclinic form (Form 1) was found to dominate the mixture of particles. However, an increase in ultrasonic irradiation time was found to increase the percentage of orthorhombic form (Form 3) in the particles indicating that the increase in ultrasonic energy facilitates formation of orthorhombic form over the monoclinic form, irrespective of the additive used. These results therefore suggest that the ultrasonic energy can be effectively used to manipulate the polymorphic outcome of the precipitation.
authors.affiliation: Chemical Engineering, Indian Institute of Technology Gandhinagar, Chandkheda, Ahmedabad 382424, Gujarat, India.
authors.forename: Alpana A
authors.initials: AA
authors.lastname: Thorat
authors.affiliation: Chemical Engineering, Indian Institute of Technology Gandhinagar, Chandkheda, Ahmedabad 382424, Gujarat, India. Electronic address: sameervd@iitgn.ac.in.
authors.forename: Sameer V
authors.initials: SV
authors.lastname: Dalvi
mesh_terms: D000464:Alginates / Q000737:chemistry; D011232:Chemical Precipitation; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D003474:Curcumin / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D012995:Solubility; D012996:Solutions; D012997:Solvents / Q000737:chemistry*; D013010:Sonication; D013499:Surface Properties
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D011136:Polysorbates; D012996:Solutions; D012997:Solvents; D020442:Poloxamer; D012967:Sodium Dodecyl Sulfate; D020723:Glucuronic Acid; D003474:Curcumin
keywords: Additives; Concomitant; Curcumin; Liquid antisolvent precipitation; Polymorphism; Poorly water soluble drug