title: Polyphenols isolated from leaves of Vitis thunbergii var. taiwaniana regulate APP related pathway.
abstract: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. The major component of the plaques, amyloid-β (Aβ), is generated from amyloid-β precursor protein (APP) by β- and γ-secretase-mediated cleavages. Multiple lines of evidence demonstrate that overproduction/accumulation of Aβ in vulnerable brain regions is a primary cause of the pathogenesis of AD. Among the twelve polyphenols isolated from the leaf extracts of Vitis thunbergii var. taiwaniana (VTT), stenophyllol C, stenophyllol B, ampelopsin C, vitisin A, and davidiol A were shown to significantly reduce both Aβ40 and Aβ42 levels in N2a695 cells. Further studies revealed that ampelopsin C and vitisin A reduce Aβ production through inhibiting β-secretase activity, while the effects of the other active polyphenols on reducing Aβ generation are through different mechanisms. These results suggest that VTT extracts may be beneficial for AD prevention and treatment.
authors.affiliation: School of Pharmaceutical Sciences, Xiamen University, South Xiangan Road, Xiamen, Fujian 361102, China; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, South Xiangan Road, Xiamen, Fujian 361102, China; School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Hu
authors.affiliation: School of Pharmaceutical Sciences, Xiamen University, South Xiangan Road, Xiamen, Fujian 361102, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Lin
authors.affiliation: School of Pharmaceutical Sciences, Xiamen University, South Xiangan Road, Xiamen, Fujian 361102, China.
authors.forename: Junyue
authors.initials: J
authors.lastname: Xu
authors.affiliation: School of Pharmaceutical Sciences, Xiamen University, South Xiangan Road, Xiamen, Fujian 361102, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Ding
authors.affiliation: School of Pharmaceutical Sciences, Xiamen University, South Xiangan Road, Xiamen, Fujian 361102, China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Wang
authors.affiliation: Fujian Institute of Subtropical Botany, Jiahe Road 800, Xiamen, Fujian 361006, China.
authors.forename: Ruichi
authors.initials: R
authors.lastname: Shen
authors.affiliation: Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, South Xiangan Road, Xiamen, Fujian 361102, China. Electronic address: yunzhang@xmu.edu.cn.
authors.forename: Yun-Wu
authors.initials: YW
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Xiamen University, South Xiangan Road, Xiamen, Fujian 361102, China. Electronic address: haifeng@xmu.edu.cn.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Chen
mesh_terms: D000072198:ADAM17 Protein / Q000378:metabolism; D000544:Alzheimer Disease / Q000188:drug therapy; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors*; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors; D045744:Cell Line, Tumor; D020536:Enzyme Activators / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D010446:Peptide Fragments / Q000037:antagonists & inhibitors*; D018515:Plant Leaves / Q000737:chemistry; D059808:Polyphenols / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D011480:Protease Inhibitors / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D013267:Stilbenes / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D027843:Vitis / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D020536:Enzyme Activators; D010446:Peptide Fragments; D059808:Polyphenols; D011480:Protease Inhibitors; D013267:Stilbenes; C078592:amyloid beta-protein (1-40); D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509282:Bace1 protein, mouse; D000072198:ADAM17 Protein
keywords: APP related pathway; Alzheimer’s disease; Aβ; Polyphenols; Vitis thunbergii var. taiwaniana