title: Genome-wide profiling to analyze the effects of FXR activation on mouse renal proximal tubular cells.
abstract: To assess the effect of farnesoid X receptor (FXR), a bile acid nuclear receptor, on renal proximal tubular cells, primary cultured mouse kidney proximal tubular cells were treated with GW4064 (a FXR agonist) or DMSO (as controls) overnight. Analysis of gene expression in the proximal tubular cells by whole genome microarrays indicated that FXR activation induced genes involved in fatty acid degradation and oxidation reduction. Among them, genes involved in glutathione metabolism were mostly induced. Here we describe in details the contents and quality controls for the gene expression and related results associated with the data uploaded to Gene Expression Omnibus (accession number GSE70296).
authors.affiliation: Department of Nephrology, Hypertension and Clinical Pharmacology, Inselspital, 3010 Bern, Switzerland.
authors.forename: Ting
authors.initials: T
authors.lastname: Gui
authors.affiliation: Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Gai
keywords: Farnesoid X receptor; Fatty acid metabolism; GW4064; Microarray; Oxidation reduction