title: Mismatch binding, ADP-ATP exchange and intramolecular signaling during mismatch repair.
abstract: The focus of this article is on the DNA binding and ATPase activities of the mismatch repair (MMR) protein, MutS-our current understanding of how this protein uses ATP to fuel its actions on DNA and initiate repair via interactions with MutL, the next protein in the pathway. Structure-function and kinetic studies have yielded detailed views of the MutS mechanism of action in MMR. How MutS and MutL work together after mismatch recognition to enable strand-specific nicking, which leads to strand excision and synthesis, is less clear and remains an active area of investigation.
authors.affiliation: Wesleyan University, Middletown, CT 06459, United States. Electronic address: mhingorani@wesleyan.edu.
authors.forename: Manju M
authors.initials: MM
authors.lastname: Hingorani
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D020137:Base Pair Mismatch; D053843:DNA Mismatch Repair; D006801:Humans; D051719:MutS DNA Mismatch-Binding Protein / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D051719:MutS DNA Mismatch-Binding Protein
keywords: ATPase mechanism; Mismatch repair; MutL; MutS; Transient kinetics