title: An implantable smart magnetic nanofiber device for endoscopic hyperthermia treatment and tumor-triggered controlled drug release.
abstract: The study describes the design and synthesis of an implantable smart magnetic nanofiber device for endoscopic hyperthermia treatment and tumor-triggered controlled drug release. This device is achieved using a two-component smart nanofiber matrix from monodisperse iron oxide nanoparticles (IONPs) as well as bortezomib (BTZ), a chemotherapeutic drug. The IONP-incorporated nanofiber matrix was developed by electrospinning a biocompatible and bioresorbable polymer, poly (d,l-lactide-co-glycolide) (PLGA), and tumor-triggered anticancer drug delivery is realized by exploiting mussel-inspired surface functionalization using 2-(3,4-dihydroxyphenyl)ethylamine (dopamine) to conjugate the borate-containing BTZ anticancer drug through a catechol metal binding in a pH-sensitive manner. Thus, an implantable smart magnetic nanofiber device can be exploited to both apply hyperthermia with an alternating magnetic field (AMF) and to achieve cancer cell-specific drug release to enable synergistic cancer therapy. These results confirm that the BTZ-loaded mussel-inspired magnetic nanofiber matrix (BTZ-MMNF) is highly beneficial not only due to the higher therapeutic efficacy and low toxicity towards normal cells but also, as a result of the availability of magnetic nanoparticles for repeated hyperthermia application and tumor-triggered controlled drug release.
  
  
  CONCLUSIONS
  The current work report on the design and development of a smart nanoplatform responsive to a magnetic field to administer both hyperthermia and pH-dependent anticancer drug release for the synergistic anticancer treatment. The iron oxide nanoparticles (IONPs) incorporated nanofiber matrix was developed by electrospinning a biocompatible polymer, poly (d,l-lactide-co-glycolide) (PLGA), and tumor-triggered anticancer drug delivery is realized by surface functionalization using 2-(3,4-dihydroxyphenyl)ethylamine (dopamine) to conjugate the boratecontaining anticancer drug bortezomib through a catechol metal binding in a pH-sensitive manner. This implantable magnetic nanofiber device can be exploited to apply hyperthermia with an alternating magnetic field and to achieve cancer cell-specific drug release to enable synergistic cancer therapy, which results in an improvement in both quality of life and patient compliance.
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea.
authors.forename: Arathyram Ramachandra Kurup
authors.initials: ARK
authors.lastname: Sasikala
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea; Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea. Electronic address: afeeshnano@gmail.com.
authors.forename: Afeesh Rajan
authors.initials: AR
authors.lastname: Unnithan
authors.affiliation: Department of Bioengineering, North Carolina Agricultural & Technical State University, Greensboro, NC 27411, United States.
authors.forename: Yeo-Heung
authors.initials: YH
authors.lastname: Yun
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea; Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea. Electronic address: biochan@jbnu.ac.kr.
authors.forename: Chan Hee
authors.initials: CH
authors.lastname: Park
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea; Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea. Electronic address: chskim@jbnu.ac.kr.
authors.forename: Cheol Sang
authors.initials: CS
authors.lastname: Kim
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D049872:Bivalvia; D000069286:Bortezomib / Q000008:administration & dosage / Q000737:chemistry; D002396:Catechols / Q000737:chemistry; D045744:Cell Line, Tumor; D004298:Dopamine / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D019723:Endoscopes; D004724:Endoscopy / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced / Q000379:methods*; D019344:Lactic Acid / Q000737:chemistry; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry; D051379:Mice; D041681:NIH 3T3 Cells; D057139:Nanofibers / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013818:Thermogravimetry
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D002396:Catechols; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D000069286:Bortezomib; D004298:Dopamine
keywords: Bortezomib; Chemotherapy; Hyperthermia; Magnetic nanofiber; Mussel-inspired