title: A nuclear magnetic resonance study of the dynamics of organofluorine interactions with a dissolved humic acid.
abstract: A quantitative understanding of the dynamics of the interactions between organofluorine compounds and humic acids will contribute to an improved understanding of the role that Natural Organic Matter plays as a mediator in the fate, transport and distribution of these contaminants in the environment. Here, Nuclear Magnetic Resonance (NMR) spectroscopy-based diffusion measurements are used to estimate the association dynamics between dissolved humic acid and selected organofluorine compounds: pentafluoroaniline, pentafluorophenol, potassium perfluorooctane sulfonate, and perfluorooctanoic acid. Under the conditions used here, the strength of the association with humic acid increases linearly as temperature decreases for all compounds except for perfluorooctanoic acid, which exhibits divergent behavior with a non-linear decrease in the extent of interaction as temperature decreases. A general interaction mechanism controlled largely by desolvation effects is suggested for all compounds examined here except for perfluorooctanoic acid, which exhibits a specific mode of interaction consistent with a proteinaceous binding site. Reverse Heteronuclear Saturation Transfer Difference NMR is used to confirm the identity and nature of the humic acid binding sites.
authors.affiliation: Department of Chemistry, University of Toronto, 1265 Military Trail, Toronto, Ontario, M1C 1A4, Canada. Electronic address: jlongsta@uoguelph.ca.
authors.forename: James G
authors.initials: JG
authors.lastname: Longstaffe
authors.affiliation: Department of Chemistry, University of Toronto, 1265 Military Trail, Toronto, Ontario, M1C 1A4, Canada. Electronic address: denis.courtiermurias@utoronto.ca.
authors.forename: Denis
authors.initials: D
authors.lastname: Courtier-Murias
authors.affiliation: Department of Chemistry, University of Toronto, 1265 Military Trail, Toronto, Ontario, M1C 1A4, Canada. Electronic address: andre.simpson@utoronto.ca.
authors.forename: Andre J
authors.initials: AJ
authors.lastname: Simpson
mesh_terms: D006812:Humic Substances; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013696:Temperature; D013816:Thermodynamics; D014874:Water Pollutants, Chemical / Q000737:chemistry*
chemical_list: D006812:Humic Substances; D006845:Hydrocarbons, Fluorinated; D014874:Water Pollutants, Chemical
keywords: Association dynamics; Humic acid; Nuclear magnetic resonance; Organofluorine contaminants