title: Moderate alcohol consumption and triglyceridemia.
abstract: The review aims to summarize current knowledge on the effects of moderate alcohol consumption (1 standard drink a day for women; 2 drinks a day for men) on triglyceride concentration in circulation. Current evidence suggests that the relationship between alcohol consumption and triglyceridemia is J-shaped. Triglyceridemia is lowest in subjects who drink 10-20 g/alcohol a day. Such a J-shaped association is comparable with that described for the relationship between alcohol and cardiovascular risk. On the contrary, alcohol taken with a meal increases and prolongs postprandial triglyceridemia. Such effects of alcohol consumption may be at least partially explained by the effects of ethanol on lipoprotein lipase (LPL) activity. Long-term moderate alcohol consumption increases LPL activity, which may explain its TG-lowering effect. On the other hand, LPL activity is acutely downregulated by ethanol, which explains increased postprandial triglyceridemia.
authors.affiliation: Laboratory for Atherosclerosis Research, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. jan.kovar@ikem.cz.
authors.forename: J
authors.initials: J
authors.lastname: Kovář
authors.forename: K
authors.initials: K
authors.lastname: Zemánková
mesh_terms: D000428:Alcohol Drinking / Q000097:blood* / Q000453:epidemiology*; D000818:Animals; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood* / Q000453:epidemiology*; D008071:Lipoprotein Lipase / Q000097:blood; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides; D008071:Lipoprotein Lipase