title: High Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation for Persistent/Relapsed Ovarian Cancer.
abstract: OBJECTIVE
  High dose chemotherapy (HDC) is increasingly being used for ovarian cancer. Although early studies of autotransplantation for advanced ovarian cancer have been encouraging, most reported series were small, and no randomized trials have been reported. HDC and autologous hematopoietic stem cell transplantation were rarely performed in patients with ovarian cancer in Korea, and no results have been reported with the exception of one case report.
  
  
  METHODS
  We retrospectively analyzed 10 patients with refractory or relapsed ovarian cancer having received HDC and autologous peripheral blood stem cell transplantation (APBSCT), between January 1996 and September 1998, at the Soon Chun Hyang and Ajou University Hospitals.
  
  
  RESULTS
  Ten patients were treated with HDC and APBSCT. Six patients achieved complete response (CR) and 1 a partial response (PR), with a response rate of 70%. Three patients did not respond following mobilization chemotherapy, and failed to respond after HDC. The median duration of progression free survival (PFS) and overall survival (OS) were 6 (4~46) and 13 (3~50+) months, respectively. The median duration of OS of the responders following mobilization chemotherapy was 23 (8~50+) compared with 12 (3~18) months of the non- responders. With regard to the treatment related toxicity, 8 patients had neutropenic fevers, and bacteremia was documented in 4. The non-hematological toxicities were never life threatening, and there were no treatment related deaths.
  
  
  CONCLUSIONS
  HDC, followed by APBSCT, is well-tolerated patients with refractory or relapsed ovarian cancer, and following mobilization chemotherapy the responders survived longer than the non-responders.
authors.forename: So Eun
authors.initials: SE
authors.lastname: Kim
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Won
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Joon Sung
authors.initials: JS
authors.lastname: Park
authors.forename: Chan Kyu
authors.initials: CK
authors.lastname: Kim
authors.forename: Kyu Taeg
authors.initials: KT
authors.lastname: Lee
authors.forename: Sung Kyu
authors.initials: SK
authors.lastname: Park
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Baick
authors.forename: Dae Sik
authors.initials: DS
authors.lastname: Hong
authors.forename: Hee Sook
authors.initials: HS
authors.lastname: Park
authors.forename: Hugh Chul
authors.initials: HC
authors.lastname: Kim
keywords: High dose chemotherapy; Ovarian neoplasm; Stem cell transplantation