title: [Clinicopathologic analysis of angioimmunoblastic T-cell lymphoma with Hodgkin/Reed-Sternberg-like cells].
abstract: OBJECTIVE
  To study the clinicopathologic features and pathologic diagnosis and differential diagnosis of angioimmunoblastic T-cell lymphoma with HRS-like cells.
  
  
  METHODS
  Six cases of angioimmunoblastic T-cell lymphoma with HRS-like cells were examined histologically and immunohistochemically (EliVision method) and in-situ hybridization for Epstein-Barr virus-encoded RNA (EBER), and the literature was reviewed.
  
  
  RESULTS
  The cytologic and microscopic features of these imprints and lymph node samples showed a heterogeneous population of hematolymphoid cells, including small to intermediate lymphoid cells, immunoblasts, plasma cells, dendritic cells, and eosinophils, as well as small vessels that were surrounded by some of the abnormal cells. The neoplastic T-cells expressed CD3 and CD5 and partly positive for CD10 and bcl-6, CD21 showed expanded and irregular follicular dendritic cell (FDC) meshworks that surrounding the high HEV. The HRS-like cells were positive for MUM-1 and Ki-67, variable intensity positive for CD30, CD20, and PAX-5, but negative for CD15. EBV-positive cells included HRS-like cells and small to large-sized neoplastic T-cells, which formed small clusters or scattering in the background of the disease.
  
  
  CONCLUSIONS
  The clinical course of angioimmunoblastic T-cell lymphoma with HRS-like cells is aggressive. Which present with histomorphology overlap with classical Hodgkin lymphoma (CHL), similar to CHL in EBER and immunophenotype, however, it is easy to misdiagnosis as HL. Thus, angioimmunoblastic T-cell lymphoma pathology diagnosis should comprehensive analysis of different kinds of materials, including clinical features, and histological structure, and EBER, and immunophenotype, and gene rearrangement.
authors.affiliation: Beijing Firendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Pathology, Jiujiang University Hospital, Jiujiang 332000, China.
authors.forename: Wenyong
authors.initials: W
authors.lastname: Huang
authors.forename: Wensheng
authors.initials: W
authors.lastname: Li
authors.forename: Jianlan
authors.initials: J
authors.lastname: Xie
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: E-mail: zhouxiaoge59@hotmail.com.
authors.forename: Xiaoge
authors.initials: X
authors.lastname: Zhou
mesh_terms: D003937:Diagnosis, Differential; D004854:Herpesvirus 4, Human; D006689:Hodgkin Disease / Q000473:pathology; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000175:diagnosis* / Q000473:pathology; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017403:In Situ Hybridization; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000473:pathology; D012367:RNA, Viral; D016539:Reed-Sternberg Cells / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral