title: Anti-Diabetic, Anti-Oxidant and Anti-Hyperlipidemic Activities of Flavonoids from Corn Silk on STZ-Induced Diabetic Mice.
abstract: Corn silk is a well-known ingredient frequently used in traditional Chinese herbal medicines. This study was designed to evaluate the anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of crude flavonoids extracted from corn silk (CSFs) on streptozotocin (STZ)-induced diabetic mice. The results revealed that treatment with 300 mg/kg or 500 mg/kg of CSFs significantly reduced the body weight loss, water consumption, and especially the blood glucose (BG) concentration of diabetic mice, which indicated their potential anti-diabetic activities. Serum total superoxide dismutase (SOD) and malondialdehyde (MDA) assays were also performed to evaluate the anti-oxidant effects. Besides, several serum lipid values including total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C) were reduced and the high density lipoprotein cholesterol level (HDL-C) was increased. The anti-diabetic, anti-oxidant and anti-hyperlipidemic effect of the CSFs suggest a potential therapeutic treatment for diabetic conditions.
authors.affiliation: College of Food Science and Engineering, Jilin University, Changchun 130062, China. zy01@jlu.edu.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Food Science and Engineering, Jilin University, Changchun 130062, China. wuliying-lisa@hotmail.com.
authors.forename: Liying
authors.initials: L
authors.lastname: Wu
authors.affiliation: College of Food Science and Engineering, Jilin University, Changchun 130062, China. zsma@jlu.edu.cn.
authors.forename: Zhongsu
authors.initials: Z
authors.lastname: Ma
authors.affiliation: College of Food Science and Engineering, Jilin University, Changchun 130062, China. chengj_369@sohu.com.
authors.forename: Jia
authors.initials: J
authors.lastname: Cheng
authors.affiliation: College of Food Science and Engineering, Jilin University, Changchun 130062, China. ljb168@sohu.com.
authors.forename: Jingbo
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000494:pharmacology; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D004326:Drinking / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology; D004435:Eating / Q000187:drug effects; D005419:Flavonoids / Q000008:administration & dosage* / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D051379:Mice; D013311:Streptozocin; D003313:Zea mays / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D013311:Streptozocin
keywords: anti-diabetic; anti-hyperlipidemic; anti-oxidant; corn silk; flavonoids