title: Decreased level of serum autoantibody against LG72 is a biosignature of amyotrophic lateral sclerosis.
abstract: OBJECTIVE
  LG72 can increase mitochondrial ROSs and oxidative stress has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS). The serum level of LG72 or LG72-related molecules might therefore be associated with ALS. Here, we aim to determine the serum autoantibody against LG72 has potential as a biomarker for the diagnosis of ALS.
  
  
  METHODS
  Seventy-eighty patients with ALS, 45 patients with AD, 43 patients with PD and 88 healthy adults were enrolled.
  
  
  RESULTS
  The concentration of serum autoantibody against LG72 was more than fourfold lower in ALS than other control groups (p < 0.001). The AUC was 0.9627 when the cut-off value for autoantibody concentration was 0.167 μg/ml.
  
  
  CONCLUSIONS
  This finding suggests that the autoantibody against LG72 might serve as a surrogate biomarker for ALS.
authors.affiliation: School of Medicine, National Yang Ming University, Taipei, Taiwan.|Department of Neurology, Taipei City Hospital - Zhong Xiao Branch, Taipei, Taiwan.
authors.forename: Chi-Shin
authors.initials: CS
authors.lastname: Hwang
authors.affiliation: Department of Neurology, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Chon-Haw
authors.initials: CH
authors.lastname: Tsai
authors.affiliation: Graduate Institute of Basic Medical Science and PhD Program for Aging, China Medical University, Taichung, Taiwan.
authors.forename: Guan-Ting
authors.initials: GT
authors.lastname: Liu
authors.affiliation: Department of Internal Medicine, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Li
authors.affiliation: Graduate Institute of Basic Medical Science and PhD Program for Aging, China Medical University, Taichung, Taiwan.|Department of Computer Science & Information Engineering, Asia University, Taichung, Taiwan.
authors.forename: Hao-Teng
authors.initials: HT
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood* / Q000175:diagnosis / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002352:Carrier Proteins / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D002352:Carrier Proteins; C475071:DAOA protein, human; D047908:Intracellular Signaling Peptides and Proteins
keywords: LG72; amyotrophic lateral sclerosis; autoantibody