title: Does glioblastoma cyst fluid promote sciatic nerve regeneration?
abstract: Glioblastoma cyst fluid contains growth factors and extracellular matrix proteins which are known as neurotrophic and neurite-promoting agents. Therefore, we hypothesized that glioblastoma cyst fluid can promote the regeneration of injured peripheral nerves. To validate this hypothesis, we transected rat sciatic nerve, performed epineural anastomosis, and wrapped the injured sciatic nerve with glioblastoma cyst fluid- or saline-soaked gelatin sponges. Neurological function and histomorphological examinations showed that compared with the rats receiving local saline treatment, those receiving local glioblastoma cyst fluid treatment had better sciatic nerve function, fewer scars, greater axon area, counts and diameter as well as fiber diameter. These findings suggest that glioblastoma cyst fluid can promote the regeneration of injured sciatic nerve and has the potential for future clinical application in patients with peripheral nerve injury.
authors.affiliation: Department of Neurosurgery, Diskapi Yıldırım Beyazıt Educational and Research Hospital, Ankara, Turkey.
authors.forename: Rafet
authors.initials: R
authors.lastname: Özay
authors.affiliation: Department of Histology and Embryology, Faculty of Veterinary Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Abit
authors.initials: A
authors.lastname: Aktaş
authors.affiliation: Department of Neurosurgery, School of Medicine, Uludağ University, Bursa, Turkey.
authors.forename: Mevlüt Özgür
authors.initials: MÖ
authors.lastname: Taşkapılıoğlu
authors.affiliation: Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey.
authors.forename: Bora
authors.identifier: 0000-0003-1500-6184
authors.initials: B
authors.lastname: Gürer
authors.affiliation: Department of Neurosurgery, School of Medicine, Fatih University, Ankara, Turkey.
authors.forename: Bülent
authors.initials: B
authors.lastname: Erdoğan
authors.affiliation: Department of Neurosurgery, School of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Yusuf Şükrü
authors.initials: YŞ
authors.lastname: Çağlar
keywords: cyst fluid; glioblastoma; growth factors; nerve regeneration; neural regeneration; peripheral nerve injury; sciatic nerve injury