title: Clinicopathologic factors associated with recurrence in low- and high-grade parotid cancers.
abstract: The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer.
  
  
  
  The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence-free survival (RFS) according to histologic grade.
  
  
  
  Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low-grade cancer (p = .049 and p = .019, respectively), whereas perineural invasion was the only significant factor in patients with high-grade cancer (p = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low-grade cancer (8.3%) and distant at high-grade cancer (13.6%). The duration of RFS was significantly longer in low-grade cancer than high-grade cancer in regional and distant recurrence (p = .044 and p = .016, respectively).
  
  
  
  Consideration of different factors may be required for individual low-grade and high-grade parotid cancers when predicting the risk of recurrence. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1788-E1793, 2016.
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Doh Young
authors.initials: DY
authors.lastname: Lee
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Ilsong Memorial Institute of Head and Neck Cancer, Hallym University, College of Medicine, Seoul, South Korea.
authors.forename: Min Woo
authors.initials: MW
authors.lastname: Park
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Kyoung Ho
authors.initials: KH
authors.lastname: Oh
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Jae-Gu
authors.initials: JG
authors.lastname: Cho
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Soon-Young
authors.initials: SY
authors.lastname: Kwon
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Jeong-Soo
authors.initials: JS
authors.lastname: Woo
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Kwang Yoon
authors.initials: KY
authors.lastname: Jung
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Seung-Kuk
authors.initials: SK
authors.lastname: Baek
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D010306:Parotid Gland / Q000473:pathology; D010307:Parotid Neoplasms / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
keywords: grade; locoregional; parotid cancer; recurrence; survival