title: Diagnosis of a growing radiation-induced skull lesion in a patient: an unusual scar.
abstract: New lesions arising from within an area of previous irradiation often present a diagnostic dilemma, with new malignancy or metastasis of particular concern. The authors report a case of reactive fibroblast proliferation emerging from a previous radiation field and presenting as a growing lesion of the frontal and parietal skull. Following complete gross resection of the skull lesion and histopathological analysis, it was discovered that this lesion consisted of dense fibroblast proliferation with areas of osteonecrosis. This unusual reactive phenomenon offers a novel differential diagnosis for a new contrast-enhancing lesion in a region of previous radiation.
authors.affiliation: Barts and the London SMD, Queen Mary University of London, United Kingdom;|Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke;
authors.forename: Andrea P
authors.initials: AP
authors.lastname: Perera
authors.affiliation: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke;
authors.forename: Gautam U
authors.initials: GU
authors.lastname: Mehta
authors.affiliation: Laboratory of Pathology; and.
authors.forename: Drew
authors.initials: D
authors.lastname: Pratt
authors.affiliation: Laboratory of Pathology; and.
authors.forename: Martha M
authors.initials: MM
authors.lastname: Quezado
authors.affiliation: Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Gilbert
authors.affiliation: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke;
authors.forename: John D
authors.initials: JD
authors.lastname: Heiss
mesh_terms: D001932:Brain Neoplasms / Q000532:radiotherapy*; D005260:Female; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis* / Q000209:etiology* / Q000601:surgery; D012888:Skull Neoplasms / Q000175:diagnosis* / Q000209:etiology* / Q000601:surgery
keywords: fibroblast; lesion; oncology; radiotherapy; skull