title: Assessment of a multi-assay biological diagnostic test for mood disorders in a Japanese population.
abstract: The current diagnostic tests for mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD), have limitations. Inflammatory markers, growth factors, and oxidative stress markers are involved in the pathophysiology of mood disorders. A multi-assay biological diagnostic test combining these biomarkers might improve diagnostic efficiency. The plasma levels of soluble tumor necrosis factor receptor 2 (sTNFR2), epidermal growth factor (EGF), and myeloperoxidase were measured in 40 MDD patients, 40 BD patients and 40 controls in a Japanese population. We also investigated the plasma levels of these markers in 40 patients with schizophrenia to determine the utility of these markers in differential diagnosis. The plasma levels of sTNFR2 were significantly higher in BD and schizophrenia patients than in controls. The plasma levels of EGF and myeloperoxidase were significantly higher in patients with BD than in controls. The correct classification rate obtained from discriminant analysis with sTNFR2 and EGF between controls and mood disorders was 69.2%, with a sensitivity and specificity of 62.5% and 82.5%, respectively. The correct classification rate obtained from discriminant analysis with sTNFR2 and EGF between controls and BD was 85.0%, with a sensitivity and specificity of 77.6% and 92.5%, respectively. Our results suggest that sTNFR2 and EGF could be biological markers of BD. Further studies are needed to determine the utility of these markers in diagnostic tests for mood disorders.
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 5650871, Japan. Electronic address: yamamori@psy.med.osaka-u.ac.jp.
authors.forename: Hidenaga
authors.initials: H
authors.lastname: Yamamori
authors.affiliation: Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Chiba 2608670, Japan.
authors.forename: Tamaki
authors.initials: T
authors.lastname: Ishima
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 5650871, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Yasuda
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 5650871, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Fujimoto
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 5650871, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Kudo
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 5650871, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ohi
authors.affiliation: Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka 5650871, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Hashimoto
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 5650871, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeda
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 5650871, Japan; Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka 5650871, Japan.
authors.forename: Ryota
authors.initials: R
authors.lastname: Hashimoto
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001714:Bipolar Disorder / Q000175:diagnosis; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000175:diagnosis; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D004815:Epidermal Growth Factor / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000175:diagnosis*; D009195:Peroxidase / Q000097:blood; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood; D012559:Schizophrenia / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D047889:Receptors, Tumor Necrosis Factor, Type II; D004815:Epidermal Growth Factor; D009195:Peroxidase
keywords: Biomarker; Bipolar disorder; Major depressive disorder; Mood disorder; Schizophrenia