title: Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case.
abstract: Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fatal and 1 surviving, treated with the novel antiparasitic agent miltefosine.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Cope
authors.affiliation: University of Texas Health Science Center, San Antonio.
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Conrad
authors.affiliation: Miami Children's Hospital, Florida.
authors.forename: Naiomi
authors.initials: N
authors.lastname: Cohen
authors.affiliation: Miami Children's Hospital, Florida.
authors.forename: Manuel
authors.initials: M
authors.lastname: Cotilla
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia US Food and Drug Administration, Laurel, Maryland.
authors.forename: Alexandre
authors.initials: A
authors.lastname: DaSilva
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Jackson
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Govinda S
authors.initials: GS
authors.lastname: Visvesvara
mesh_terms: D000981:Antiprotozoal Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D020808:Central Nervous System Protozoal Infections / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000401:mortality / Q000469:parasitology*; D002648:Child; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D016848:Naegleria fowleri / Q000187:drug effects / Q000302:isolation & purification; D010767:Phosphorylcholine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine
keywords: Naegleria fowleri; miltefosine; primary amebic meningoencephalitis