title: Profile of HIV-Infected Hispanics with Pancytopenia.
abstract: Pancytopenia is seen in late HIV infection; it is associated with medical complications and with decreased survival. We determined the prevalence of pancytopenia at baseline in a cohort of HIV-positive Hispanics living in Puerto Rico, and compared their socio-demographic, immunological and clinical characteristics. A total of 1202 patients enrolled between 2000 and 2010 were included. They were grouped according to pancytopenia status, defined by having: platelets <150,000 μL, white cell count <4000 μL, and hemoglobin <12 g/dL (women) or <13 g/dL (men). Differences were evaluated using Student's t-test, Chi-square test and Kaplan-Meier method. The prevalence of pancytopenia was 8.7%. Patients with pancytopenia had lower BMI and lower CD4 count, as well as higher HIV viral load and higher proportions of unemployment, clinical AIDS and antiretroviral treatment (ART) use (p < 0.05). One-year mortality rate was significantly higher in patients with pancytopenia (18.1% vs. 5.1%, p < 0.001). When stratifying for ART this association persisted for patients who did not receive ART (41.4% vs. 5.2%, p < 0.001), but it was not seen in patients who received treatment (9.2% vs. 5.6%, p = 0.196). Pancytopenia was associated with elements of advanced stages of HIV. ART could reduce the mortality of HIV-patients with pancytopenia to levels comparable to patients without the disorders.
authors.affiliation: Retrovirus Research Center, Internal Medicine Department, School of Medicine, Universidad Central del Caribe, Bayamón, Puerto Rico 00960, USA. eduardo.santiago@uccaribe.edu.
authors.forename: Eduardo J
authors.initials: EJ
authors.lastname: Santiago-Rodríguez
authors.affiliation: Retrovirus Research Center, Internal Medicine Department, School of Medicine, Universidad Central del Caribe, Bayamón, Puerto Rico 00960, USA. amayorb@gmail.com.
authors.forename: Angel M
authors.initials: AM
authors.lastname: Mayor
authors.affiliation: Retrovirus Research Center, Internal Medicine Department, School of Medicine, Universidad Central del Caribe, Bayamón, Puerto Rico 00960, USA. diana.fernandez@uccaribe.edu.
authors.forename: Diana M
authors.initials: DM
authors.lastname: Fernández-Santos
authors.affiliation: Retrovirus Research Center, Internal Medicine Department, School of Medicine, Universidad Central del Caribe, Bayamón, Puerto Rico 00960, USA. robert.hunter@uccaribe.edu.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Hunter-Mellado
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000821:virology; D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000208:ethnology / Q000401:mortality; D006630:Hispanic or Latino; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010198:Pancytopenia / Q000188:drug therapy / Q000208:ethnology* / Q000401:mortality / Q000821:virology; D015995:Prevalence; D011647:Puerto Rico / Q000453:epidemiology; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents
keywords: HIV; Hispanics; antiretroviral treatment; blood disorders; mortality; pancytopenia; prevalence