title: Alcohol Use Disorder Increases the Risk of Irritable Bowel Disease: A Nationwide Retrospective Cohort Study.
abstract: Alcohol use disorder (AUD) is considered a possible risk factor for irritable bowel syndrome (IBS); however, previous studies investigating the association between AUD and IBS have yielded inconsistent results. The study investigated whether AUD increases the risk of IBS by using a population-based database in Taiwan.This retrospective matched-cohort study included the health insurance claims data of 56,355 AUD inpatients and 225,420 randomly selected controls by frequency-matched for sex, age, and index year. Cox proportional hazards regression analysis was performed to measure the risk of IBS among AUD patients compared with non-AUD patients.During the follow-up period, the incidence rate ratio (IRR) of IBS had 12.3-fold (95% CI: 11.9-12.7) in the AUD patients than non-AUD patients and the adjusted hazard ratio (aHR) for IBS in the AUD patients was 5.51 (95% CI: 4.36-6.96). For several comorbidities, the risk of IBS was significantly higher in the AUD patients than in non-AUD patients, with aHRs of 2.14 (95% confidence interval [CI]: 1.19-3.84), 2.05 (95% CI: 1.06-3.96), and 2.91 (95% CI: 1.26-6.72) for sleep disorders, acute pancreatitis, and hepatitis B, respectively. When we stratified the severity of AUD according to the length of hospital stay, the aHRs exhibited a significant correlation (P < 0.001) with severity, yielding aHRs of 3.24 (95% CI: 2.49-4.22), 11.9 (95% CI: 8.96-15.9), and 26.1 (95% CI: 19.4-35.2) for mild, moderate, and severe AUD, respectively.The risk of IBS was higher among AUD patients, and increased with the length of hospital stay.
authors.affiliation: From the Department of Emergency Medicine, China Medical University Hospital (T-YH, C-YC, W-KC), School of Medicine, College of Medicine, China Medical University, Taichung (T-YH, C-YC, W-KC), Department of Dermatology, National Taiwan University Hospital, Yunlin Branch, Douliou (G-YH), Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei (G-YH), Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan (Y-CW), Altitude Research Center, Department of Emergency Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Denver, Colorado, USA (S-HW), Taiwan Wilderness Medical Association, Taipei (S-HW), Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University (C-HK); and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (C-HK).
authors.forename: Tai-Yi
authors.initials: TY
authors.lastname: Hsu
authors.forename: Guan-Yi
authors.initials: GY
authors.lastname: He
authors.forename: Yu-Chiao
authors.initials: YC
authors.lastname: Wang
authors.forename: Chih-Yu
authors.initials: CY
authors.lastname: Chen
authors.forename: Shih-Hao
authors.initials: SH
authors.lastname: Wang
authors.forename: Wei-Kung
authors.initials: WK
authors.lastname: Chen
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Kao
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D019973:Alcohol-Related Disorders / Q000453:epidemiology*; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D007345:Insurance Claim Review; D043183:Irritable Bowel Syndrome / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D013624:Taiwan / Q000453:epidemiology