title: Towards real-time communication betweenin vivoneurophysiological data sources and simulator-based brain biomimetic models.
abstract: Development of more sophisticated implantable brain-machine interface (BMI) will require both interpretation of the neurophysiological data being measured and subsequent determination of signals to be delivered back to the brain. Computational models are the heart of the machine of BMI and therefore an essential tool in both of these processes. One approach is to utilize brain biomimetic models (BMMs) to develop and instantiate these algorithms. These then must be connected as hybrid systems in order to interface the BMM within vivodata acquisition devices and prosthetic devices. The combined system then provides a test bed for neuroprosthetic rehabilitative solutions and medical devices for the repair and enhancement of damaged brain. We propose here a computer network-based design for this purpose, detailing its internal modules and data flows. We describe a prototype implementation of the design, enabling interaction between the Plexon Multichannel Acquisition Processor (MAP) server, a commercial tool to collect signals from microelectrodes implanted in a live subject and a BMM, a NEURON-based model of sensorimotor cortex capable of controlling a virtual arm. The prototype implementation supports an online mode for real-time simulations, as well as an offline mode for data analysis and simulations without real-time constraints, and provides binning operations to discretize continuous input to the BMM and filtering operations for dealing with noise. Evaluation demonstrated that the implementation successfully delivered monkey spiking activity to the BMM through LAN environments, respecting real-time constraints.
authors.affiliation: Department of Electrical and Computer Engineering, University of Florida, P.O. Box 116200, 216 Larsen Hall, Gainesville 32611, FL, USA.
authors.forename: Giljae
authors.initials: G
authors.lastname: Lee
authors.affiliation: Department of Electrical and Computer Engineering, University of Florida, P.O. Box 116200, 216 Larsen Hall, Gainesville 32611, FL, USA.
authors.forename: Andréa
authors.initials: A
authors.lastname: Matsunaga
authors.affiliation: Department of Physiology and Pharmacology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn 11203, NY, USA.
authors.forename: Salvador
authors.initials: S
authors.lastname: Dura-Bernal
authors.affiliation: Department of Electrical and Computer Engineering, University of Florida, P.O. Box 116200, 216 Larsen Hall, Gainesville 32611, FL, USA.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Physiology and Pharmacology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn 11203, NY, USA ; Department of Neurology, State University New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn 11203, NY, USA ; Department of Neurology, Kings County Hospital, 450 Clarkson Avenue, Brooklyn 11203, NY, USA ; Joint Program in Biomedical Engineering at Polytechnic Institute of New York University and State University of New York Downstate, 450 Clarkson Avenue, Brooklyn 11203, NY, USA ; Program in Neural and Behavioral Science at State University of New York Downstate, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA ; The Robert F. Furchgott Center for Neural & Behavioral Science, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA.
authors.forename: William W
authors.initials: WW
authors.lastname: Lytton
authors.affiliation: Department of Physiology and Pharmacology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn 11203, NY, USA ; Joint Program in Biomedical Engineering at Polytechnic Institute of New York University and State University of New York Downstate, 450 Clarkson Avenue, Brooklyn 11203, NY, USA ; Program in Neural and Behavioral Science at State University of New York Downstate, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA ; The Robert F. Furchgott Center for Neural & Behavioral Science, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA.
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Francis
authors.affiliation: Department of Electrical and Computer Engineering, University of Florida, P.O. Box 116200, 216 Larsen Hall, Gainesville 32611, FL, USA ; Department of Computer and Information Science and Engineering, University of Florida, P.O. Box 116120, E301 CSE Building, Gainesville 32611, FL, USA.
authors.forename: José Ab
authors.initials: JA
authors.lastname: Fortes
keywords: Biomimetic models; Brain-machine interfaces; Computational neuroscience; Neuroprosthetics