title: Successful use of Tenecteplase in a patient with recurrence of prosthetic mitral valve thrombosis.
abstract: BACKGROUND
  Tenecteplase can be a more effective and convenient alternative in treatment of prosthetic valve thrombosis (PVT).
  
  
  METHODS
  We hereby present a case of the use of Tenecteplase for recurrence of mitral valve thrombosis in a patient who was brought as an emergency with breathing difficulty at rest. A single intravenous bolus of Tenecteplase relieved her symptoms dramatically within a few hours. This is in contradistinction to her earlier similar presentation with valve thrombosis a year back, when both streptokinase and urokinase had not worked.
  
  
  CONCLUSIONS
  The use of Tenecteplase in PVT is reasonable, but needs more documentation. The therapeutic response was remarkable in our case. It is also better suited for recurrence of valve thrombosis as streptokinase cannot be used for a second time.
authors.affiliation: Senior Resident, Department of Cardiology, Bombay Hospital Institute of Medical Sciences, Bombay Hospital, 12, New Marine Lines, Mumbai 400020, India. Electronic address: harshal_dr@yahoo.com.
authors.forename: Harshal A
authors.initials: HA
authors.lastname: Lahoti
authors.affiliation: Director, Interventional Cardiology and Hon. Dean, Bombay Hospital Institute of Medical Sciences, Bombay Hospital, 12, New Marine Lines, Mumbai 400020, India.
authors.forename: Bal Krishna
authors.initials: BK
authors.lastname: Goyal
mesh_terms: D000328:Adult; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006331:Heart Diseases / Q000188:drug therapy* / Q000209:etiology; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008943:Mitral Valve; D008946:Mitral Valve Stenosis / Q000601:surgery; D011475:Prosthesis Failure; D012008:Recurrence; D000077785:Tenecteplase; D015912:Thrombolytic Therapy / Q000379:methods*; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator; D000077785:Tenecteplase
keywords: Mitral valve; Prosthesis and implants; Tenecteplase; Thrombosis