title: Emerging strategies for managing differentiated thyroid cancers refractory to radioiodine.
abstract: Efficient treatment of radio refractory thyroid cancer is still a major challenge. The recent identification of genetic and epigenetic alterations present in almost all differentiated tumors has revealed novel molecular targets, which can hopefully be exploited to create new treatments for these tumors. This review looks briefly at some of the innovative strategies currently being investigated for the treatment the radioiodine-resistant thyroid cancers.
authors.affiliation: Department of Health Sciences, University "Magna Graecia" of Catanzaro, Campus "S. Venuta", 88100, Catanzaro, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Bulotta
authors.affiliation: Department of Health Sciences, University "Magna Graecia" of Catanzaro, Campus "S. Venuta", 88100, Catanzaro, Italy.
authors.forename: Marilena
authors.initials: M
authors.lastname: Celano
authors.affiliation: Department of Health Sciences, University "Magna Graecia" of Catanzaro, Campus "S. Venuta", 88100, Catanzaro, Italy.|Endocrinology Clinic, Internal Medicine Department, Institut Jules Bordet Comprehensive Cancer Center, Brussels, Belgium.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Costante
authors.affiliation: Department of Health Sciences, University "Magna Graecia" of Catanzaro, Campus "S. Venuta", 88100, Catanzaro, Italy. d.russo@unicz.it.
authors.forename: Diego
authors.initials: D
authors.lastname: Russo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D063646:Carcinogenesis / Q000187:drug effects; D016503:Drug Delivery Systems; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D058990:Molecular Targeted Therapy; D049329:Nanostructures / Q000737:chemistry; D011989:Receptors, Thyrotropin / Q000819:agonists; D013964:Thyroid Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes; D011989:Receptors, Thyrotropin
keywords: Differentiated thyroid cancer; Molecular targets; Nanodevices; Radioiodine; Re-differentiation strategies