title: Association between serum soluble corin and hyperglycaemia: a cross-sectional study among Chinese adults.
abstract: OBJECTIVE
  Decreased natriuretic peptides are risk factors for diabetes. As a physiological activator of natriuretic peptides, corin may play a role in glucose metabolism. Here, we aimed to test the hypothesis in a general population of China.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  A population study in Suzhou, China.
  
  
  METHODS
  A total of 2498 participants aged above 30 years were included in the study.
  
  
  METHODS
  The association between serum soluble corin and hyperglycaemia was examined in men and women, using non-conditional logistic regression models, respectively.
  
  
  RESULTS
  Serum soluble corin, in men and women, was significantly higher in participants with hyperglycaemia than in those without (all p<0.001). OR of hyperglycaemia positively and significantly increased with serum soluble corin quartiles, in men (p for trend <0.001) and in women (p for trend=0.050), even after multivariate adjustment. Participants with a serum soluble corin, in men (OR=1.66, 95% CI 1.24 to 2.23) and women (OR=1.27, 95% CI 1.00 to 1.61), over the median level, were more likely to have hyperglycaemia compared with the remaining participants, after controlling for confounding factors.
  
  
  CONCLUSIONS
  Hyperglycaemia was significantly and positively associated with increased serum soluble corin in men and women. Our findings suggest that serum soluble corin may be a risk factor or a biomarker of hyperglycaemia.
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Peng
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, China Center for Disease Prevention and Control of Gusu District, Suzhou, China.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, China.
authors.forename: Peipei
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, China.
authors.forename: Yunfan
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Center for Disease Prevention and Control of Gusu District, Suzhou, China.
authors.forename: Xiangqin
authors.initials: X
authors.lastname: Chao
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D012697:Serine Endopeptidases / Q000097:blood*
chemical_list: D015415:Biomarkers; C119812:CORIN protein, human; D012697:Serine Endopeptidases
keywords: Fasting plasma glucose; Serum soluble corin