title: Tula hantavirus infection in a hospitalised patient, France, June 2015.
abstract: We report an infection with Tula virus in June 2015, leading to hospitalisation, in a patient living approximately 60 km east of Paris with no previous remarkable medical history. Clinical symptoms were limited to a fever syndrome with severe headache. The main laboratory findings included thrombocytopenia and elevated transaminase levels. Based on S (small) gene sequence analysis, the strain affecting the patient was closely related to strains detected in Central Europe, especially to a south-east German strain.
authors.affiliation: Centre National de Référence des Hantavirus, Unité de Biologie des Infections Virales Emergentes, Institut Pasteur, Centre International de Recherche en Infectiologie, Lyon, France.
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Reynes
authors.forename: Damien
authors.initials: D
authors.lastname: Carli
authors.forename: Nourredine
authors.initials: N
authors.lastname: Boukezia
authors.forename: Monique
authors.initials: M
authors.lastname: Debruyne
authors.forename: Samir
authors.initials: S
authors.lastname: Herti
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D005334:Fever / Q000209:etiology*; D006476:Orthohantavirus / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification*; D018778:Hantavirus Infections / Q000175:diagnosis*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D060888:Real-Time Polymerase Chain Reaction; D017421:Sequence Analysis; D013921:Thrombocytopenia
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D002097:C-Reactive Protein; D000410:Alanine Transaminase
keywords: France; clinic; epidemiology; hantavirus; hantavirus infections; laboratory; laboratory surveillance; viral infections; zoonotic infections