title: Update on Breast Cancer Detection Using  Comb-Push Ultrasound Shear Elastography.
abstract: In this work, tissue stiffness estimates are used to differentiate between benign and malignant breast masses in a group of pre-biopsy patients. The rationale is that breast masses are often stiffer than healthy tissue; furthermore, malignant masses are stiffer than benign masses. The comb-push ultrasound shear elastography (CUSE) method is used to noninvasively assess a tissue's mechanical properties. CUSE utilizes a sequence of simultaneous multiple laterally spaced acoustic radiation force (ARF) excitations and detection to reconstruct the region of interest (ROI) shear wave speed map, from which a tissue stiffness property can be quantified. In this study, the tissue stiffnesses of 73 breast masses were interrogated. The mean shear wave speeds for benign masses (3.42 ± 1.32 m/s) were lower than malignant breast masses (6.04 ± 1.25 m/s). These speed values correspond to higher stiffness in malignant breast masses (114.9 ± 40.6 kPa) than benign masses (39.4 ± 28.1 kPa and p <; 0.001), when tissue elasticity is quantified by Young's modulus. A Young's modulus >83 kPa is established as a cut-off value for differentiating between malignant and benign suspicious breast masses, with a receiver operating characteristic curve (ROC) of 89.19% sensitivity, 88.69% specificity, and 0.911 for the area under the curve (AUC).
authors.forename: Max
authors.initials: M
authors.lastname: Denis
authors.forename: Mahdi
authors.initials: M
authors.lastname: Bayat
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mehrmohammadi
authors.forename: Adriana
authors.initials: A
authors.lastname: Gregory
authors.forename: Pengfei
authors.initials: P
authors.lastname: Song
authors.forename: Dana H
authors.initials: DH
authors.lastname: Whaley
authors.forename: Sandhya
authors.initials: S
authors.lastname: Pruthi
authors.forename: Shigao
authors.initials: S
authors.lastname: Chen
authors.forename: Mostafa
authors.initials: M
authors.lastname: Fatemi
authors.forename: Azra
authors.initials: A
authors.lastname: Alizad
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D012372:ROC Curve