title: Clinical performance of a novel ultrathin strut, low-dose, sirolimus-eluting stent with abluminal-only biodegradable polymeric coating for patients undergoing percutaneous coronary intervention in the daily practice.
abstract: BACKGROUND
  The present study aimed to evaluate the clinical performance, in the daily practice of a busy catheterization laboratory, of a novel drug-eluting stent (DES) built with an ultra-thin-strut metallic platform, eluting sirolimus at low doses, abluminal coated with biodegradable polymers, and mounted in a low-compliant delivery system.
  
  
  METHODS
  Prospective, single-arm study, comprising all consecutive patients undergoing percutaneous coronary intervention (PCI) with the Inspiron™ sirolimus-eluting stent (SES) (Scitech, Aparecida de Goiania, Brazil). The primary endpoint was the occurrence of major adverse cardiac events (MACE) [cardiac death, non-PCI related myocardial infarction (MI), or target vessel revascularization (TVR)].
  
  
  RESULTS
  A total of 470 patients were included, from which 51.3% were diabetics, 33.8% had triple-vessel disease, 15.3% had heart failure, 38.9% had at least one bifurcation treated, 19.8% were treated for a bare metal stent restenosis, and 61.9% had at least one type C lesion; one or more of these features were found in 96.0%. At 300 days, the rate target lesion revascularization was 5.4% and the rate of MACE was 8.1%. The incidence of definite or probable stent thrombosis was 0.4%, with no cases between 30 and 300 days.
  
  
  CONCLUSIONS
  The novel stent is associated with excellent short and mid-term clinical outcomes in patients treated with PCI in the daily practice.
authors.affiliation: Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, Brazil.
authors.forename: Guy F A
authors.initials: GF
authors.lastname: Prado
authors.affiliation: Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, Brazil.
authors.forename: Expedito E
authors.initials: EE
authors.lastname: Ribeiro
authors.affiliation: Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, Brazil.
authors.forename: Pedro H M C
authors.initials: PH
authors.lastname: Melo
authors.affiliation: Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, Brazil.
authors.forename: Fabio A
authors.initials: FA
authors.lastname: Pinton
authors.affiliation: Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, Brazil.
authors.forename: Antonio
authors.initials: A
authors.lastname: Esteves-Filho
authors.affiliation: Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, Brazil.
authors.forename: Celso K
authors.initials: CK
authors.lastname: Takimura
authors.affiliation: Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, Brazil.
authors.forename: Jose
authors.initials: J
authors.lastname: Mariani
authors.affiliation: Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, Brazil.
authors.forename: Luiz J
authors.initials: LJ
authors.lastname: Kajita
authors.affiliation: Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, Brazil.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Marchiori
authors.affiliation: Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, Brazil.
authors.forename: Breno de Alencar
authors.initials: Bde A
authors.lastname: Araripe Falcao
authors.affiliation: Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, Brazil.
authors.forename: Micheli Z
authors.initials: MZ
authors.lastname: Galon
authors.affiliation: Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, Brazil.
authors.forename: Paulo R
authors.initials: PR
authors.lastname: Soares
authors.affiliation: Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, Brazil.
authors.forename: Silvio
authors.initials: S
authors.lastname: Zalc
authors.affiliation: Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, Brazil.
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Lemos
keywords: Biodegradable polymer; complex lesions; drug-eluting stent (DES); sirolimus-eluting stent (SES); stent thrombosis