title: Comparison of the Fitting Validity Between the 2P Model and the Nondilute Solution Model Using Statistical Methods in Modeling Cell Membrane Permeabilities.
abstract: In cryopreservation, the two-parameter (2P) model and the nondilute solution model have been developed to study the membrane transport properties of cells. However, to our knowledge, comparison of the fitting validity has never been made between the two models. In this study, to make this comparison, the permeability parameters of porcine adipose-derived stem cells (pADSCs) were first determined with the two models, and then the errors between the predictions and the experimental data were tested using the Lilliefors test. The results indicate that the 2P model is slightly better than the nondilute solution model in predicting the mass transport across cell membrane. The causes for this phenomenon are discussed and suggestions on using these two models are given.
authors.affiliation: 1 Centre for Biomedical Engineering, Department of Electronic Science and Technology, University of Science and Technology of China , Hefei, Anhui, China .
authors.forename: Yuntian
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 1 Centre for Biomedical Engineering, Department of Electronic Science and Technology, University of Science and Technology of China , Hefei, Anhui, China .|2 Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs , Hefei, Anhui, China .
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
authors.affiliation: 1 Centre for Biomedical Engineering, Department of Electronic Science and Technology, University of Science and Technology of China , Hefei, Anhui, China .
authors.forename: Jingru
authors.initials: J
authors.lastname: Yi
authors.affiliation: 3 Department of Mechanical Engineering, University of Washington , Seattle, Washington.
authors.forename: Zhiquan
authors.initials: Z
authors.lastname: Shu
authors.affiliation: 2 Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs , Hefei, Anhui, China .|4 Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University , Hefei, China .
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.affiliation: 2 Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs , Hefei, Anhui, China .|4 Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University , Hefei, China .
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Cao
authors.affiliation: 2 Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs , Hefei, Anhui, China .|3 Department of Mechanical Engineering, University of Washington , Seattle, Washington.
authors.forename: Dayong
authors.initials: D
authors.lastname: Gao
mesh_terms: D002462:Cell Membrane / Q000187:drug effects; D015925:Cryopreservation / Q000379:methods*; D003451:Cryoprotective Agents / Q000009:adverse effects; D015233:Models, Statistical
chemical_list: D003451:Cryoprotective Agents