title: Signaling in the innate immune response.
abstract: The nematode Caenorhabditis elegans relies on its innate immune defenses to counter infection. In this review, we focus on its response to infection by bacterial and fungal pathogens. We describe the different families of effector proteins that contribute to host defense, as well as the signal transduction pathways that regulate their expression. We discuss what is known of the activation of innate immunity in C. elegans, via pathogen recognition or sensing the damage provoked by infection. Damage causes a stress response; we review the role of stress signaling in host defense to infection. We examine examples of inter-tissue communication in innate immunity and end with a survey of post-transcriptional regulation of innate immune responses.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
authors.forename: Dennis H
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, INSERM, U1104, CNRS UMR7280, 13288 Marseille, France.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Ewbank
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology; D017173:Caenorhabditis elegans / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D005658:Fungi / Q000276:immunology; D007113:Immunity, Innate / Q000235:genetics; D015398:Signal Transduction