title: RNA Systems Biology for Cancer: From Diagnosis to Therapy.
abstract: It is due to the advances in high-throughput omics data generation that RNA species have re-entered the focus of biomedical research. International collaborate efforts, like the ENCODE and GENCODE projects, have spawned thousands of previously unknown functional non-coding RNAs (ncRNAs) with various but primarily regulatory roles. Many of these are linked to the emergence and progression of human diseases. In particular, interdisciplinary studies integrating bioinformatics, systems biology, and biotechnological approaches have successfully characterized the role of ncRNAs in different human cancers. These efforts led to the identification of a new tool-kit for cancer diagnosis, monitoring, and treatment, which is now starting to enter and impact on clinical practice. This chapter is to elaborate on the state of the art in RNA systems biology, including a review and perspective on clinical applications toward an integrative RNA systems medicine approach. The focus is on the role of ncRNAs in cancer.
authors.affiliation: Department of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.
authors.forename: Raheleh
authors.initials: R
authors.lastname: Amirkhah
authors.affiliation: Department of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Farazmand
authors.affiliation: Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany.|Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University, Stellenbosch, South Africa.
authors.forename: Olaf
authors.initials: O
authors.lastname: Wolkenhauer
authors.affiliation: Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany. ulf.schmitz@uni-rostock.de.
authors.forename: Ulf
authors.initials: U
authors.lastname: Schmitz
mesh_terms: D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D034622:RNA Interference; D012334:RNA, Neoplasm; D049490:Systems Biology / Q000379:methods; D016896:Treatment Outcome
chemical_list: D012334:RNA, Neoplasm
keywords: Bioinformatics tools; Biomarker prediction; Integrative workflows; Non-coding RNA; Systems biology methods; Therapeutic target identification; microRNA