title: Specific self-monitoring of metal-associated amyloid-β peptide disaggregation by a fluorescent chelator.
abstract: A dual-functional fluorescent chelator can specifically target and disassemble metal-associated Aβ aggregates and simultaneously self-monitor the disaggregation by fluorescence in brain homogenates of mice with Alzheimer's disease.
authors.affiliation: College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China. wangxhui@njtech.edu.cn yaocheng@njtech.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.affiliation: College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China. wangxhui@njtech.edu.cn yaocheng@njtech.edu.cn and State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P. R. China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Nanjing Xiaozhuang College, Nanjing, 210017, P. R. China.
authors.forename: Changli
authors.initials: C
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P. R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P. R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, Yancheng Teachers University, Yancheng 224002, P. R. China.
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China. wangxhui@njtech.edu.cn yaocheng@njtech.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Luo
authors.affiliation: College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China. wangxhui@njtech.edu.cn yaocheng@njtech.edu.cn.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.affiliation: College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China. wangxhui@njtech.edu.cn yaocheng@njtech.edu.cn.
authors.forename: Cheng
authors.initials: C
authors.lastname: Yao
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, 210093, P. R. China. boxwxy@nju.edu.cn.
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Wang
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D010446:Peptide Fragments / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D002614:Chelating Agents; D005456:Fluorescent Dyes; D010446:Peptide Fragments