title: Improvement of Apolipoprotein B in Argentine Indigenous School Children after Vitamin D Supplementation.
abstract: OBJECTIVE
  To determine whether vitamin D supplementation improves non-traditional cardiovascular risk factors such as Apo B levels among indigenous children.
  
  
  METHODS
  A prospective two-year study evaluated a treated cohort of 190 children (104 males) aged 9.4+ 2.2 years. Children were divided into group A (n=104; 54.7%) and group B (n=86; 45.3%). Both groups received vitamin D supplementation with 100,000 u/year; group B was treated in 2013 and group A in 2014. All subjects were evaluated at the end of each treatment and anthropometric measures, lipids and vitamin D levels between the two groups were compared.
  
  
  RESULTS
  Changes in vitamin D levels were significantly higher in Group A, which was supplied in 2014, than in group B, which was not supplied in 2014 (6.8 vs 0.96 ng/dL; respectively). Levels of LDL-C and Apo B were improved in group A versus B: LDL-C (-5.7 vs 6.9 mg/dL respectively) and Apo B (-0.9 vs 11. mg/dL respectively). Several multiple regression linear analyses showed that changes in vitamin D were significantly associated with lower LDL-C levels (Beta- 0.41, p<0.01; R2 0.07); and with lower Apo B levels (Beta-0.37, p<0.01; R2 0.17).
  
  
  CONCLUSIONS
  Vitamin D supplementation among indigenous children could improve Apo B levels.
authors.affiliation: From the University of Buenos Aires, Argentina Maipu 812 5 M Buenos Aires (1006), Argentina. vhirschler@intramed.net.
authors.forename: Valeria
authors.initials: V
authors.lastname: Hirschler
authors.forename: Gustavo
authors.initials: G
authors.lastname: Maccallini
authors.forename: Milva
authors.initials: M
authors.lastname: Sanchez
authors.forename: Gonzalez
authors.initials: G
authors.lastname: Claudio
authors.forename: Claudia
authors.initials: C
authors.lastname: Molinari
authors.forename: Marcelo
authors.initials: M
authors.lastname: Figueroa
authors.forename: Claudio
authors.initials: C
authors.lastname: Arnada
authors.forename: Mariana
authors.initials: M
authors.lastname: Hidalgo
mesh_terms: D001055:Apolipoproteins B / Q000097:blood*; D001118:Argentina; D002648:Child; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D044382:Population Groups; D011446:Prospective Studies; D014807:Vitamin D
chemical_list: D001055:Apolipoproteins B; D014807:Vitamin D