title: Acylphloroglucinol derivatives from Decaspermum gracilentum and their antiradical and cytotoxic activities.
abstract: Two new acylphloroglucinol derivatives, 1-(hexanoyl)phloroglucinol-α-d-arabinopyranoside (1) and 1-(hexanoyl)phloroglucinol-β-d-glucopyranoside (2), along with two known ones, 1-(acetyl)phloroglucinol-β-d-glucopyranoside (3) and ethyl 2,4,6-trihydroxybenzoate (4), were isolated from the EtOAc soluble fraction of EtOH extract of Decaspermum gracilentum. The structures of the new compounds were determined by extensive spectroscopic analyses including HRESIMS, 1D and 2D NMR data. Interestingly, all of the compounds showed ABTS(·+) radical scavenging activity with the IC50 values less than 10 μM. Furthermore, compounds 3 and 4 displayed moderate cytotoxicity on human non-small-cell lung carcinoma cell line A549 (IC50 = 50.9 μΜ) and human renal carcinoma cell line 786-O (IC50 = 38.6 μΜ), respectively.
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 , China.
authors.forename: Meng
authors.initials: M
authors.lastname: Sun
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 , China.
authors.forename: Fekadu-Roge
authors.initials: FR
authors.lastname: Gobu
authors.affiliation: b Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences & Gansu Key laboratory of Space Radiobiology , Institute of Modern Physics, Chinese Academy of Sciences , Lanzhou 730000 , China.
authors.forename: Dong
authors.initials: D
authors.lastname: Pan
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 , China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 , China.
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D027822:Myrtaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry
chemical_list: C000608711:1-(hexanoyl)phloroglucinol-alpha-D-arabinopyranoside; C000608712:1-(hexanoyl)phloroglucinol-beta-D-glucopyranoside; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D006027:Glycosides; C575103:ethyl 2,4,6-trihydroxybenzoate; D005707:Gallic Acid; D010696:Phloroglucinol
keywords: Decaspermum gracilentum; Myrtaceae; acylphloroglucinol derivatives; cytotoxic activity; radical scavenging activity