title: Glyceradehyde-3-phosphate dehydrogenase as a suitable vaccine candidate for protection against bacterial and parasitic diseases.
abstract: The enzyme glyceraldehyde-3-P-dehydrogenase (GAPDH) has been identified as having other properties in addition to its key role in glycolysis. The ability of GAPDH to bind to numerous extracellular matrices, modulation of host-immune responses, a role in virulence and surface location has prompted numerous investigators to postulate that GAPDH may be a good vaccine candidate for protection against numerous pathogens. Although immune responses against GAPDH have been described for many microorganisms, vaccines containing GAPDH have been successfully tested in few cases including those against the trematode-Schistosoma mansoni, the helminth-Enchinococcus multilocularis; the nematode filaria- Litomosoides sigmodontis; fish pathogens such as Aeromonas spp., Vibrio spp., Edwarsiella spp., and Streptococcus iniae; and environmental streptococci, namely, Streptococcus uberis and Streptococcus dysgalactiae. Before GAPDH-based vaccines are considered viable options for protection against numerous pathogens, we need to take into account the homology between the host and pathogen GAPDH proteins to prevent potential autoimmune reactions, thus protective GAPDH epitopes unique to the pathogen protein must be identified.
authors.affiliation: Vaccine and Infectious Disease Organization, 120 Veterinary Rd. , Saskatoon, Saskatchewan S7N 5E3, Canada. Electronic address: jose.perez-casal@usask.ca.
authors.forename: Jose
authors.initials: J
authors.lastname: Perez-Casal
authors.affiliation: Vaccine and Infectious Disease Organization, 120 Veterinary Rd. , Saskatoon, Saskatchewan S7N 5E3, Canada.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Potter
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control*; D001428:Bacterial Vaccines / Q000276:immunology; D003429:Cross Reactions; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000276:immunology*; D006801:Humans; D010272:Parasitic Diseases / Q000517:prevention & control*
chemical_list: D001428:Bacterial Vaccines; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases
keywords: GAPDH; Protection; Vaccines