title: Gut bacterial diversity of the tribes of India and comparison with the worldwide data.
abstract: The gut bacteria exert phenotypic traits to the host but the factors which determine the gut bacterial profile (GBP) is poorly understood. This study aimed to understand the effect of ethnicity and geography on GBP of Mongoloid and Proto-Australoid tribes of India. Fecal bacterial diversity was studied in fifteen tribal populations representing four geographic regions (Assam, Telangana, Manipur and Sikkim) by DGGE followed by NGS analysis on Illumina MiSeq platform. Geography and diet had significant effect on GBP of the Indian tribes which was dominated by Prevotella. The effects were more prominent with lower taxonomic levels, indicating probable functional redundancy of the core GBP. A comparison with the worldwide data revealed that GBP of the Indian population was similar to the Mongolian population (Mongolia). The bacterial genera Faecalibacterium, Eubacterium, Clostridium, Blautia, Ruminococcus and Roseburia were found to be core genera in the representative populations of the world.
authors.affiliation: Molecular Biology and Microbial Biotechnology Laboratory, Life Science Division, Institute of Advanced Study in Science and Technology (IASST), An autonomous institute under Department of Science and Technology (Govt. of India), Paschim Boragaon, Garchuk, Guwahati-781035, Assam, India.
authors.forename: Madhusmita
authors.initials: M
authors.lastname: Dehingia
authors.affiliation: Institute of Bioresources &Sustainable Development (IBSD), An autonomous institute under Department of Biotechnology (Govt. of India), Takyelpat, Imphal-795001, Manipur, India.
authors.forename: Kanchal Thangjam
authors.initials: KT
authors.lastname: Devi
authors.affiliation: Molecular Biology and Microbial Biotechnology Laboratory, Life Science Division, Institute of Advanced Study in Science and Technology (IASST), An autonomous institute under Department of Science and Technology (Govt. of India), Paschim Boragaon, Garchuk, Guwahati-781035, Assam, India.|Institute of Bioresources &Sustainable Development (IBSD), An autonomous institute under Department of Biotechnology (Govt. of India), Takyelpat, Imphal-795001, Manipur, India.
authors.forename: Narayan C
authors.initials: NC
authors.lastname: Talukdar
authors.affiliation: Asian Healthcare Foundation/Asian Institute of Gastroenterology (AIG), 6-3-661, Somajiguda, Hyderabad-082, Telangana, India.
authors.forename: Rupjyoti
authors.initials: R
authors.lastname: Talukdar
authors.affiliation: Asian Healthcare Foundation/Asian Institute of Gastroenterology (AIG), 6-3-661, Somajiguda, Hyderabad-082, Telangana, India.
authors.forename: Nageshwar
authors.initials: N
authors.lastname: Reddy
authors.affiliation: Head of Bio-Sciences R&D, TCS Innovation Labs, Tata Consultancy Services Ltd. 54-B, Hadapsar Industrial Estate, Pune-411013, Maharastra, India.
authors.forename: Sharmila S
authors.initials: SS
authors.lastname: Mande
authors.affiliation: Head of Department of Applied Sciences, Gauhati University, Guwahati-781014, Assam, India.
authors.forename: Manab
authors.initials: M
authors.lastname: Deka
authors.affiliation: Molecular Biology and Microbial Biotechnology Laboratory, Life Science Division, Institute of Advanced Study in Science and Technology (IASST), An autonomous institute under Department of Science and Technology (Govt. of India), Paschim Boragaon, Garchuk, Guwahati-781035, Assam, India.
authors.forename: Mojibur R
authors.initials: MR
authors.lastname: Khan
mesh_terms: D000328:Adult; D044822:Biodiversity; D058645:Denaturing Gradient Gel Electrophoresis; D005006:Ethnicity; D005243:Feces / Q000382:microbiology; D005260:Female; D000069196:Gastrointestinal Microbiome; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D007194:India; D038622:Internationality; D008297:Male; D058974:Phylogeography; D016133:Polymerase Chain Reaction; D025341:Principal Component Analysis; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D055815:Young Adult
chemical_list: D012336:RNA, Ribosomal, 16S