title: Associations of Urinary Uromodulin with Clinical Characteristics and Markers of Tubular Function in the General Population.
abstract: OBJECTIVE
  Allelic variants in UMOD, the gene coding for uromodulin, are associated with rare tubulointerstitial kidney disorders and risk of CKD and hypertension in the general population. The factors associated with uromodulin excretion in the normal population remain largely unknown, and were therefore explored in this study.
  
  
  METHODS
  Urinary uromodulin excretion was measured using a validated ELISA in two population-based cohorts that included more than 6500 individuals. The Swiss Kidney Project on Genes in Hypertension study (SKIPOGH) included 817 adults (mean age±SD, 45±17 years) who underwent renal ultrasonography and performed a 24-hour urine collection. The Cohorte Lausannoise study included 5706 adults (mean age, 53±11 years) with fresh spot morning urine samples. We calculated eGFRs using the CKD-Epidemiology Collaboration formula and by 24-hour creatinine clearance.
  
  
  RESULTS
  In both studies, positive associations were found between uromodulin and urinary sodium, chloride, and potassium excretion and osmolality. In SKIPOGH, 24-hour uromodulin excretion (median, 41 [interquartile range, 29-57] mg/24 h) was positively associated with kidney length and volume and with creatinine excretion and urine volume. It was negatively associated with age and diabetes. Both spot uromodulin concentration and 24-hour uromodulin excretion were linearly and positively associated (multivariate analyses) with eGFR<90 ml/min per 1.73 m(2).
  
  
  CONCLUSIONS
  Age, creatinine excretion, diabetes, and urinary volume are independent clinical correlates of urinary uromodulin excretion. The associations of uromodulin excretion with markers of tubular functions and kidney dimensions suggest that it may reflect tubule activity in the general population.
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Menno
authors.initials: M
authors.lastname: Pruijm
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Belen
authors.initials: B
authors.lastname: Ponte
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ackermann
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Fred
authors.initials: F
authors.lastname: Paccaud
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Idris
authors.initials: I
authors.lastname: Guessous
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Georg
authors.initials: G
authors.lastname: Ehret
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Antoinette
authors.initials: A
authors.lastname: Pechère-Bertschi
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Bruno
authors.initials: B
authors.lastname: Vogt
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Markus G
authors.initials: MG
authors.lastname: Mohaupt
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Martin
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Sonia C
authors.initials: SC
authors.lastname: Youhanna
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Nadine
authors.initials: N
authors.lastname: Nägele
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Peter
authors.initials: P
authors.lastname: Vollenweider
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Gérard
authors.initials: G
authors.lastname: Waeber
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors.forename: Michel
authors.initials: M
authors.lastname: Burnier
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material. murielle.bochud@chuv.ch olivier.devuyst@uzh.ch.
authors.forename: Olivier
authors.initials: O
authors.lastname: Devuyst
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material. murielle.bochud@chuv.ch olivier.devuyst@uzh.ch.
authors.forename: Murielle
authors.initials: M
authors.lastname: Bochud
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000652:urine; D015415:Biomarkers; D004573:Electrolytes / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007684:Kidney Tubules / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D058949:Uromodulin / Q000652:urine*
chemical_list: D015415:Biomarkers; D004573:Electrolytes; D058949:Uromodulin
keywords: electrolytes; glomerular filtration rate; humans; hypertension, renal; osmolality; potassium; renal insufficiency, chronic; renal tubular cells; sodium; uromodulin