title: Switchable supramolecular catalysis using DNA-templated scaffolds.
abstract: Switchable β-cyclodextrin (β-CD)-induced hydrolysis of m-tert-butylphenyl acetate is demonstrated in the presence of supramolecular β-CD/adamantane oligonucleotide scaffolds. In one system, a duplex between a β-CD-functionalized nucleic acid and an adamantane-nucleic acid leads to a switchable catalytic system. In a second system, a β-CD/adamantane duplex is cooperatively generated by K(+)-stabilized G-quadruplex units. The binding of hemin to the second system yields a bifunctional DNA scaffold with alternate catalytic functions.
authors.affiliation: Institute of Chemistry, The Minerva Center for Biohybrid Complex Systems, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. willnea@vms.huji.ac.il.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Aleman Garcia
authors.affiliation: Institute of Chemistry, The Minerva Center for Biohybrid Complex Systems, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. willnea@vms.huji.ac.il.
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Institute of Chemistry, The Minerva Center for Biohybrid Complex Systems, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. willnea@vms.huji.ac.il.
authors.forename: Itamar
authors.initials: I
authors.lastname: Willner
mesh_terms: D000218:Adamantane / Q000737:chemistry* / Q000378:metabolism; D021881:DNA, Catalytic / Q000737:chemistry* / Q000378:metabolism; D054856:G-Quadruplexes; D006427:Hemin / Q000737:chemistry* / Q000378:metabolism; D006868:Hydrolysis; D049329:Nanostructures / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D010648:Phenylacetates / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D021881:DNA, Catalytic; D009841:Oligonucleotides; D010648:Phenylacetates; D047392:beta-Cyclodextrins; C000609348:m-tert-butylphenyl acetate; D006427:Hemin; C031215:betadex; D000218:Adamantane