title: Picomolar detection of carcinoembryonic antigen in whole blood using microfluidics and surface-enhanced Raman spectroscopy.
abstract: Carcinoembryonic antigen (CEA) is a wide-spectrum biomarker. Clinically, we generally use serum sample to detect CEA, which needs to be centrifuged to pretreat the raw blood sample. In this study, we realized direct CEA detection in raw blood samples exploiting microfluidics. The LOD was as low as 10(-12) M.
authors.affiliation: The Second Hospital of Dalian Medical University, Dalian, P. R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Zou
authors.affiliation: School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian, P. R. China.|State Key Laboratory of Fine Chemicals, Department of Chemical Engineering, Dalian University of Technology, Dalian, P. R. China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Gao
authors.affiliation: School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian, P. R. China.|State Key Laboratory of Fine Chemicals, Department of Chemical Engineering, Dalian University of Technology, Dalian, P. R. China.
authors.forename: Quanfeng
authors.initials: Q
authors.lastname: Deng
authors.affiliation: School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian, P. R. China.|State Key Laboratory of Fine Chemicals, Department of Chemical Engineering, Dalian University of Technology, Dalian, P. R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Luo
authors.affiliation: The Second Hospital of Dalian Medical University, Dalian, P. R. China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zou
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, P. R. China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Lu
authors.affiliation: School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian, P. R. China.|State Key Laboratory of Fine Chemicals, Department of Chemical Engineering, Dalian University of Technology, Dalian, P. R. China.
authors.forename: Weijie
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, P. R. China.
authors.forename: Bingcheng
authors.initials: B
authors.lastname: Lin
mesh_terms: D002272:Carcinoembryonic Antigen / Q000097:blood*; D006046:Gold / Q000737:chemistry; D057230:Limit of Detection; D058185:Magnetite Nanoparticles / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D002272:Carcinoembryonic Antigen; D058185:Magnetite Nanoparticles; D006046:Gold
keywords: Carcinoembryonic antigen; Magnetic nanoparticles; Microfluidics; SERS