title: Biotransformation effects on anti lipogenic activity of citrus extracts.
abstract: Citrus peel is a good source of flavonoids, with higher content in relation to pulp. This study proposed to investigate the anti-lipogenic potential of a newly developed citrus flavonoids extract, obtained from citrus industrial residue, bioprocessed in order to generate a commercial source of some flavonoids naturally found in low quantity. The results showed that the citrus peel extract obtained after biotransformation was a good source of hesperitin and naringenin, flavonoids that has no source for production on a large scale, as in supplements or medicines. Still, the results showed that all extracts could be used in obesity treatment. The original extract, "In Natura", would be useful to reduce new adipocytes synthesis and lipid accumulation, and the extract bioprocessed, "Biotransformed" extract could be used to induce lipolysis on fat tissue.
authors.affiliation: Department of Food and Nutrition, Faculty of Food Engineering, State University of Campinas - UNICAMP, Rua Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, CP 6121, CEP 13083-862 Campinas, SP, Brazil. Electronic address: vania_nakajima@yahoo.com.br.
authors.forename: Vânia Mayumi
authors.initials: VM
authors.lastname: Nakajima
authors.affiliation: Department of Food Engineering, Faculty of Food Engineering, State University of Campinas - UNICAMP, Rua Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, CP 6121, CEP 13083-862 Campinas, SP, Brazil.
authors.forename: José Valdo
authors.initials: JV
authors.lastname: Madeira
authors.affiliation: Department of Food and Nutrition, Faculty of Food Engineering, State University of Campinas - UNICAMP, Rua Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, CP 6121, CEP 13083-862 Campinas, SP, Brazil.
authors.forename: Gabriela Alves
authors.initials: GA
authors.lastname: Macedo
authors.affiliation: Department of Food and Nutrition, Faculty of Food Engineering, State University of Campinas - UNICAMP, Rua Monteiro Lobato, 80, Cidade Universitária Zeferino Vaz, CP 6121, CEP 13083-862 Campinas, SP, Brazil.
authors.forename: Juliana Alves
authors.initials: JA
authors.lastname: Macedo
mesh_terms: D017667:Adipocytes / Q000187:drug effects*; D000818:Animals; D002957:Citrus; D044950:Flavanones / Q000494:pharmacology*; D006569:Hesperidin / Q000494:pharmacology*; D008066:Lipolysis / Q000187:drug effects*; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D044950:Flavanones; D010936:Plant Extracts; D006569:Hesperidin; C005273:naringenin; C013015:hesperetin
keywords: Adipocytes; Biotransformation; Citrus peel extract; Hesperidin; Hesperidin (PubChem CID: 3594); Hesperitin; Hesperitin (PubChem CID: 72281); Lipolysis; Naringenin; Naringenin (PubChem CID: 932); Naringin; Naringin (PubChem CID: 74787988)