title: Ammi Visnaga in treatment of urolithiasis and hypertriglyceridemia.
abstract: Ammi visnaga is a widely distributed Ancient Egyptian medicinal plant used for treatment of several diseases including urolithiasis (kidney stones). The active chemical constituents' khellin and visnagin obtained from the A. visnaga seeds have activity of antilithiogenic and pleiotropic. However, little is known about its activity on hypertriglyceridemia. The main aim of this review is to explore the use of A. visnaga in urolithiasis and to present a case of relevancy. We highlighted a case of a patient who has recurrent urethral stones and hypertriglyceridemia. The patient was treated with A. visnaga seeds, has recovered completely from ureteral stones and his high-density lipoprotein (HDL)-cholesterol low levels retained to normal after using of A. visnaga seeds for 10 days. The present case of A. visnaga seeds being local medicinal plant has shown the effect in treating urolithiasis with extended effect on raising HDL-cholesterol. These results may provide insights for in vitro studies for isolation of these biologically active compounds for potential in raising HDL-cholesterol. Whether or not the later effect can have clinical utility remains to be explored.
authors.affiliation: Department of Clinical Pharmacy, University of Gondar College of Medicine and Health Sciences, Gondar, Ethiopia.
authors.forename: Akshaya Srikanth
authors.initials: AS
authors.lastname: Bhagavathula
authors.affiliation: Department of Neurosciences, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
authors.forename: Ahed Jumah
authors.initials: AJ
authors.lastname: Mahmoud Al-Khatib
authors.affiliation: Department of Pharmacology, College of Medicine and Health Sciences, UAE University, Al Ain, UAE.
authors.forename: Asim Ahmed
authors.initials: AA
authors.lastname: Elnour
authors.affiliation: Department of Pharmacy, Tawam Hospital, Abu Dhabi, UAE.
authors.forename: Naama M S
authors.initials: NM
authors.lastname: Al Kalbani
authors.affiliation: Department of Internal Medicine, College of Medicine and Health Sciences, UAE University, Al Ain, UAE.
authors.forename: Abdulla
authors.initials: A
authors.lastname: Shehab
keywords: Ammi visnaga; high-density lipoprotein; khellin; ureteral stones; urolithiasis; visnagin