title: Isonitrile alkylations: a rapid route to imidazo[1,5-a]pyridines.
abstract: Metalated arylmethylisonitriles readily add to 2-chloropyridines to afford imidazo[1,5-a]pyridines. Analogous additions to imidoyl chlorides and a chloroquinoline provide imidazoles and an imidazo[1,5-a]quinolone which, like imidazo[1,5-a]pyridines, are valuable heterocycles for pharmaceutical synthesis.
authors.affiliation: Department of Chemistry, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104-2875, USA. fleming@drexel.edu.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Chemistry, Duquesne University, 600 Forbes Ave, Pittsburgh, PA 15282, USA.
authors.forename: Allen
authors.initials: A
authors.lastname: Chao
authors.affiliation: Department of Chemistry, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104-2875, USA. fleming@drexel.edu.
authors.forename: Fraser F
authors.initials: FF
authors.lastname: Fleming
mesh_terms: D000478:Alkylation; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007093:Imidazoles; D009570:Nitriles; D011725:Pyridines; C083126:2-chloropyridine