title: Are epigenetic drugs for diabetes and obesity at our door step?
abstract: Recent interest in epigenetics has focused on small molecules aimed at modifying disease-specific gene expression, including diabetes and obesity. Several major classes of epigenetic modifier include drugs already in the marketplace as well as several in various stages of study. These classes include histone deacetylase inhibitors (HDACi), histone acetyltransferase inhibitors (HATi), protein arginine methyltransferase inhibitors (PRMTis), DNA methyltransferase inhibitors (DNMTis), histone demethylating inhibitors (HDMis), and sirtuin-activating compounds (STACs). In this review, we discuss drugs with epigenetic properties that have been identified as potential therapeutic agents in the treatment of diabetes and obesity, including those currently in clinical trials.
authors.affiliation: Department of Pharmaceutical Science, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, TX, USA.
authors.forename: Andrix O
authors.initials: AO
authors.lastname: Arguelles
authors.affiliation: Department of Pharmaceutical Science, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, TX, USA.
authors.forename: Sunitha
authors.initials: S
authors.lastname: Meruvu
authors.affiliation: Department of Pharmacy Practice, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, TX, USA.
authors.forename: John D
authors.initials: JD
authors.lastname: Bowman
authors.affiliation: Department of Pharmaceutical Science, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, TX, USA. Electronic address: mchoudhury@pharmacy.tamhsc.edu.
authors.forename: Mahua
authors.initials: M
authors.lastname: Choudhury
mesh_terms: D000818:Animals; D015254:DNA Modification Methylases / Q000037:antagonists & inhibitors; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D051548:Histone Acetyltransferases / Q000037:antagonists & inhibitors; D056572:Histone Deacetylase Inhibitors / Q000627:therapeutic use; D056466:Histone Demethylases / Q000037:antagonists & inhibitors; D006801:Humans; D009765:Obesity / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D037761:Sirtuins / Q000378:metabolism
chemical_list: D056572:Histone Deacetylase Inhibitors; D056466:Histone Demethylases; D015254:DNA Modification Methylases; D051548:Histone Acetyltransferases; D037761:Sirtuins