title: Relationship of insulin-like growth factor 1 and bone parameters in 7-15 years old apparently, healthy Indian children.
abstract: OBJECTIVE
  Growth hormone through insulin-like growth factor 1 (IGF-1) plays an important role in both bone growth and mineralization. This cross-sectional study was carried out to evaluate the relationship between serum IGF-1 concentrations and dual energy X-ray (DXA) measured whole body less head bone area (BA), lean body mass (LBM), and bone mineral content (BMC).
  
  
  METHODS
  One hundred and nineteen children (boys = 70, age = 7.3-15.6 years) were studied for their anthropometric parameters by standard methods and bone and body composition by DXA. Their fasting serum IGF-1 concentrations were assessed by enzyme-linked immunosorbent assay and Z-scores were calculated using available reference data. Bone and body composition parameter Z-scores were calculated using ethnic reference data.
  
  
  RESULTS
  Mean age of the boys and girls was similar (11.5 ± 1.8 years). The mean serum IGF-1concentrations and IGF-1 Z-scores were similar (P > 0.1) between boys and girls and were of the order of (302.3 ± 140.0 and - 1.4 ± 1.1, respectively). The LBM for age and BA for age Z-score was greater in children with IGF-1 Z-score > median than children with IGF-1 Z-score < median. The mean BMC for age Z-scores were 0.4 ± 0.9 and - 0.2 ± 0.8 in children with above and below the median of IGF-1 Z-score (P > 0.1).
  
  
  CONCLUSIONS
  Serum IGF-1 levels were more strongly associated with BA and LBM, suggesting that its effect on bone is greater with respect to periosteal bone acquisition and through its effect on muscle mass.
authors.affiliation: Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.
authors.forename: Veena H
authors.initials: VH
authors.lastname: Ekbote
authors.affiliation: Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.
authors.forename: Vaman V
authors.initials: VV
authors.lastname: Khadilkar
authors.affiliation: Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.
authors.forename: Anuradha V
authors.initials: AV
authors.lastname: Khadilkar
authors.affiliation: Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, M13 9WL, UK.
authors.forename: Zulf
authors.initials: Z
authors.lastname: Mughal
authors.affiliation: Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.
authors.forename: Shashi A
authors.initials: SA
authors.lastname: Chiplonkar
authors.affiliation: Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.
authors.forename: Sonal A
authors.initials: SA
authors.lastname: Palande
authors.affiliation: Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.
authors.forename: Supriya S
authors.initials: SS
authors.lastname: Phanse-Gupte
authors.affiliation: Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.
authors.forename: Vivek G
authors.initials: VG
authors.lastname: Patwardhan
authors.affiliation: Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.
authors.forename: Dhanashri S
authors.initials: DS
authors.lastname: Shilvant
keywords: Bone mineral content; Indian children; insulin-like growth factor 1