title: Hybrid Fluorinated and Hydrogenated Double-Chain Surfactants for Handling Membrane Proteins.
abstract: Two hybrid fluorinated double-chain surfactants with a diglucosylated polar head were synthesized. The apolar domain consists of a perfluorohexyl main chain and a butyl hydrogenated branch as a side chain. They were found to self-assemble into small micelles at low critical micellar concentrations, demonstrating that the short branch increases the overall hydrophobicity while keeping the length of the apolar domain short. They were both able to keep the membrane protein bacteriorhodopsin stable, one of them for at least 3 months.
authors.affiliation: Institut des Biomolécules Max Mousseron UMR 5247 CNRS-Université Montpellier-ENSCM & Avignon Université , Equipe Chimie Bioorganique et Systèmes Amphiphiles, 301 rue Baruch de Spinoza BP 21239, 84916 Cedex 9 Avignon, France.
authors.forename: Fréderic
authors.initials: F
authors.lastname: Legrand
authors.affiliation: Université Grenoble Alpes, IBS , F-38044 Grenoble, France.|CNRS, IBS , F-38044 Grenoble, France.|CEA, IBS , F-38044 Grenoble, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Breyton
authors.affiliation: Institut des Biomolécules Max Mousseron UMR 5247 CNRS-Université Montpellier-ENSCM & Avignon Université , Equipe Chimie Bioorganique et Systèmes Amphiphiles, 301 rue Baruch de Spinoza BP 21239, 84916 Cedex 9 Avignon, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Guillet
authors.affiliation: Université Grenoble Alpes, IBS , F-38044 Grenoble, France.|CNRS, IBS , F-38044 Grenoble, France.|CEA, IBS , F-38044 Grenoble, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Ebel
authors.affiliation: Institut des Biomolécules Max Mousseron UMR 5247 CNRS-Université Montpellier-ENSCM & Avignon Université , Equipe Chimie Bioorganique et Systèmes Amphiphiles, 301 rue Baruch de Spinoza BP 21239, 84916 Cedex 9 Avignon, France.
authors.forename: Grégory
authors.initials: G
authors.lastname: Durand
mesh_terms: D001436:Bacteriorhodopsins / Q000737:chemistry* / Q000378:metabolism; D054879:Halogenation; D006865:Hydrogenation; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D055550:Protein Stability; D013500:Surface Tension; D013501:Surface-Active Agents; D013816:Thermodynamics
chemical_list: D008565:Membrane Proteins; D013501:Surface-Active Agents; D001436:Bacteriorhodopsins