title: Correlation between polymorphisms in the MFN1 gene and myopia in Chinese population.
abstract: OBJECTIVE
  To explore whether genetic variations in the MFN1 gene are associated with low to moderate myopia in Chinese population.
  
  
  METHODS
  The case-control association analysis was used. The study included 100 independent myopia patients (-0.75 D ≤ spherical refraction ≤-8.00 D) and 100 sex-matched healthy controls (with binocular spherical equivalent ranges between -0.50 D and +0.50 D). Four single nucleotide polymorphism (SNP) tags (rs3976523, rs13098637, rs6762399 and rs7618348) were selected for genotyping by direct sequencing. The frequencies of genotypes and their alleles were calculated based on the number of SNP genotypes in each sample. The Chi-square test was used to examine the difference in the frequency between the myopia cases and controls.
  
  
  RESULTS
  Genotype distributions in the four SNPs were all in accordance with the Hardy-Weinberg equilibrium; analysis showed that rs13098637 was significantly associated with low to moderate myopia (P=0.003 and empirical P=0.010). There were no statistically significant differences observed for the genotype or allele frequencies of the other three SNPs between the myopia cases and controls in the Chinese population in this study.
  
  
  CONCLUSIONS
  The current study has revealed that the C allele of rs13098637 in MFN1 had a significant association with low to moderate myopia.
authors.affiliation: Department of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Yun-Chun
authors.initials: YC
authors.lastname: Zou
authors.affiliation: Department of Laboratory Medicine, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Jia-Hong
authors.initials: JH
authors.lastname: Lei
authors.affiliation: Department of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Xu
keywords: MFN1 gene; association analysis; myopia; single nucleotide polymorphism