title: Verrucous Carcinoma of the Vulva: A 20 Year Retrospective Study and Literature Review.
abstract: OBJECTIVE
  The aim of the study was to assess the clinicopathological characteristics of patients with verrucous carcinoma (VC) of the vulva.
  
  
  METHODS
  We reviewed data on the age, disease course, clinical manifestation, pathologic diagnosis, treatment, and follow-up of patients with vulvar VC who were treated at Tianjin Medical University General Hospital and cases that were reported in the Chinese and English literature during the past 20 years.
  
  
  RESULTS
  Six cases were identified in Tianjin Medical University General Hospital, the mean age of patients was 55 years, and their mean disease course was 26 months. Primary symptoms were exophytic neoplasm with pruritus and/or pain. Surgical treatment included wide local excision, simple vulvectomy, and radical vulvectomy with or without lymph node dissection in the groin. Vulvar VC occurred simultaneously with vulvar intraepithelial neoplasia in 2 cases and well-differentiated squamous cell carcinoma in 2 cases. The mean follow-up was 16.8 months with no recurrence in those 6 cases. During the 20-year period, 20 and 41 cases were reported in Chinese and English literature, respectively. Three cases were misdiagnosed with giant condyloma acuminatum in China. One case (1/20) was reported with coexistent squamous carcinoma in Chinese literature and 8 cases (8/41) in the English literature. The recurrence rate was 12.5% (2/19) and 17.5% (7/40) in Chinese and English literature, respectively.
  
  
  CONCLUSIONS
  Vulvar VC is a distinct type of slow-growing, nonmetastatic tumor with unclear etiology. These tumors should be distinguished from giant condyloma acuminatum and well-differentiated squamous cell carcinoma. Surgery is the most effective treatment.
authors.affiliation: Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China.
authors.forename: Guoyan
authors.initials: G
authors.lastname: Liu
authors.forename: Qianwen
authors.initials: Q
authors.lastname: Li
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Shang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Qi
authors.forename: Cha
authors.initials: C
authors.lastname: Han
authors.forename: Yingmei
authors.initials: Y
authors.lastname: Wang
authors.forename: Fengxia
authors.initials: F
authors.lastname: Xue
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018289:Carcinoma, Verrucous / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D002681:China; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery