title: B7-1 Blockade Does Not Improve Post-Transplant Nephrotic Syndrome Caused by Recurrent FSGS.
abstract: FSGS is a common glomerular disorder that has a high propensity for recurrence after kidney transplant. The pathophysiology of FSGS is unknown, but podocytes seem to be the target of one or several circulating factors that lead to cytoskeleton reorganization and proteinuria. Research on podocytes has identified B7-1 as an important factor in podocyte biology and a new therapeutic target in renal disease. Indeed, in four patients with recurrent FSGS after transplant, treatment with the B7-1 blocker abatacept was associated with proteinuria remission. Here, we prospectively treated nine patients with recurrent FSGS after transplant using either abatacept or belatacept, a B7-1 blocker with higher affinity, and did not induce proteinuria remission. Furthermore, we did not detect B7-1 expression by immunofluorescence in podocytes of biopsy specimens from these or other kidney grafts or podocytes of native kidney biopsy specimens. In conclusion, B7-1 blockade did not induce FSGS remission after transplant in our study.
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Service de Biothérapie.
authors.forename: Marianne
authors.initials: M
authors.lastname: Delville
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U1151, Institut Necker Enfants Malades.
authors.forename: Emilie
authors.initials: E
authors.lastname: Baye
authors.affiliation: Service de Néphrologie et Transplantation, Hôpital Bicêtre, Le Kremlin-Bicêtre, Institut National de la Santé et de la Recherche Médicale 1197, Université Paris-Saclay, Le Kremlin Bicêtre, France;
authors.forename: Antoine
authors.initials: A
authors.lastname: Durrbach
authors.affiliation: Groupe Hospitalier Henri Mondor Albert Chenevier, Service de Néphrologie et Transplantation, Université Paris Est Créteil, Creteil, France;
authors.forename: Vincent
authors.initials: V
authors.lastname: Audard
authors.affiliation: Groupe Hospitalier Henri Mondor Albert Chenevier, Service de Néphrologie et Transplantation, Université Paris Est Créteil, Creteil, France;
authors.forename: Tomek
authors.initials: T
authors.lastname: Kofman
authors.affiliation: Service de Néphrologie et Transplantation, Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, Strasbourg, France;
authors.forename: Laura
authors.initials: L
authors.lastname: Braun
authors.affiliation: Service de Néphrologie et Transplantation, Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, Strasbourg, France; Laboratoire d'Anatomo-Pathologie, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Strasbourg, France;
authors.forename: Jérôme
authors.initials: J
authors.lastname: Olagne
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U1151, Institut Necker Enfants Malades.
authors.forename: Clément
authors.initials: C
authors.lastname: Nguyen
authors.affiliation: Service de Néphrologie pédiatrique, Hôpital Robert Debré, Paris, France;
authors.forename: Georges
authors.initials: G
authors.lastname: Deschênes
authors.affiliation: Service de Néphrologie et Transplantation, Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, Strasbourg, France;
authors.forename: Bruno
authors.initials: B
authors.lastname: Moulin
authors.affiliation: Service de Néphrologie Transplantation, Hôpital Foch, Suresnes, France; and.
authors.forename: Michel
authors.initials: M
authors.lastname: Delahousse
authors.affiliation: Service de Néphrologie pédiatrique, Centre Hospitalier Universitaire de Nantes, Nantes, France.
authors.forename: Gwenaëlle
authors.initials: G
authors.lastname: Kesler-Roussey
authors.affiliation: Service de Néphrologie et Transplantation, Hôpital Bicêtre, Le Kremlin-Bicêtre, Institut National de la Santé et de la Recherche Médicale 1197, Université Paris-Saclay, Le Kremlin Bicêtre, France;
authors.forename: Séverine
authors.initials: S
authors.lastname: Beaudreuil
authors.affiliation: Service de Néphrologie Transplantation Adultes, and.
authors.forename: Frank
authors.initials: F
authors.lastname: Martinez
authors.affiliation: Service d'Anatomie et Cytologie Pathologiques, Hôpital Necker-Enfants Malades, Paris, France;
authors.forename: Marion
authors.initials: M
authors.lastname: Rabant
authors.affiliation: Groupe Hospitalier Henri Mondor Albert Chenevier, Service de Néphrologie et Transplantation, Université Paris Est Créteil, Creteil, France;
authors.forename: Philippe
authors.initials: P
authors.lastname: Grimbert
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Institut National de la Santé et de la Recherche Médicale U1151, Institut Necker Enfants Malades.
authors.forename: Morgan
authors.initials: M
authors.lastname: Gallazzini
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Institut National de la Santé et de la Recherche Médicale U1151, Institut Necker Enfants Malades.
authors.forename: Fabiola
authors.initials: F
authors.lastname: Terzi
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Service de Néphrologie Transplantation Adultes, and.
authors.forename: Christophe
authors.initials: C
authors.lastname: Legendre
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Institut National de la Santé et de la Recherche Médicale U1151, Institut Necker Enfants Malades, Service de Néphrologie Transplantation Adultes, and guillaume.canaud@inserm.fr.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Canaud
mesh_terms: D000069594:Abatacept / Q000494:pharmacology* / Q000627:therapeutic use*; D000328:Adult; D018122:B7-1 Antigen / Q000037:antagonists & inhibitors*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000517:prevention & control*; D011183:Postoperative Complications / Q000209:etiology* / Q000517:prevention & control*; D011446:Prospective Studies; D012008:Recurrence; D017211:Treatment Failure; D055815:Young Adult
chemical_list: D018122:B7-1 Antigen; D007166:Immunosuppressive Agents; D000069594:Abatacept
keywords: focal segmental glomerulosclerosis; podocyte; signaling; transplantation