title: Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses.
abstract: The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides' clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.
authors.affiliation: Deakin University , Greelong, Victoria, Australia ; CSIRO Australian Animal Health Laboratory , Newcomb, Victoria, Australia.
authors.forename: Sahar G
authors.initials: SG
authors.lastname: Eid
authors.affiliation: Hudson Institute of Medical Research , Clayton, Victoria, Australia.
authors.forename: Niamh E
authors.initials: NE
authors.lastname: Mangan
authors.affiliation: Hudson Institute of Medical Research , Clayton, Victoria, Australia.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Hertzog
authors.affiliation: Deakin University , Greelong, Victoria, Australia ; CSIRO Australian Animal Health Laboratory , Newcomb, Victoria, Australia.
authors.forename: Johnson
authors.identifier: 0000-0002-5229-5707
authors.initials: J
authors.lastname: Mak