title: Automatic measurement of interburst interval in premature neonates using range EEG.
abstract: OBJECTIVE
  To explore the direct measure of EEG amplitude (range EEG, rEEG) for detection of interburst intervals (IBIs) and bursts in neonates.
  
  
  METHODS
  Previously described 177 two-channel EEG recordings 3-6h long from 26 preterm infants (median gestational age of 26 weeks) at 23-38 weeks post-menstrual age (PMA) without major abnormalities were used to test four definitions of IBI detection algorithms with various settings of the parameters.
  
  
  RESULTS
  As the basis for all four algorithms we developed the aggregation of rEEG signal over the channels by taking its maximum, and method of EEG trace selection at different phases of sleep-wake cycle (with different degree of discontinuity). The two less restrictive algorithms - with one and two amplitude thresholds - turned to be the most promising definitions. There were enough IBI detections for analysis, with no substantial difference in mean and maximum values of intervals. The longest IBI were measured at the location of greater discontinuity. Values of bursts and IBI indices as well as association with PMA were close to the published normative values derived manually.
  
  
  CONCLUSIONS
  rEEG as a direct measure of EEG amplitude can be used for detection of bursts and IBI.
  
  
  CONCLUSIONS
  The automatic measurement of IBI based on rEEG provides a basis for improvements in neonatal brain monitoring.
authors.affiliation: National Centre for Classification in Health, Faculty of Health Sciences, The University of Sydney, Australia. Electronic address: michael.navakatikyan@sydney.edu.au.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Navakatikyan
authors.affiliation: Boston Children's Hospital, Newborn Medicine and Harvard Medical School, Boston, MA, United States.
authors.forename: Deirdre
authors.initials: D
authors.lastname: O'Reilly
authors.affiliation: Department of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Van Marter
mesh_terms: D001921:Brain / Q000254:growth & development / Q000502:physiology*; D015331:Cohort Studies; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development / Q000502:physiology*; D008297:Male; D012894:Sleep Stages / Q000502:physiology*
keywords: Burst and IBI detection; Electroencephalography (EEG); Interburst interval (IBI); Neonates; Postmenstrual age (PMA); Range-EEG (rEEG)