title: Evaluation of the protective effect of N-acetylcysteine on contrast media nephropathy.
abstract: BACKGROUND
  Intravenous contrast agents can cause acute decline in kidney function, especially in patients with risk factors.
  
  
  OBJECTIVE
  In this study, we aimed to examine the ameliorative effect N-acetylcysteine (NAC) to reduce the incidence of contrast nephropathy.
  
  
  METHODS
  This study was a prospective, randomized, double-blind clinical trial on 150 patients who underwent coronary angiography. The study was carried out on patients undergoing coronary angiography. Patients were randomly assigned into 2 groups of intervention group and control subjects. Intervention group took NAC 600 mg orally twice a day. It was administered one day before angiography and continued until the second day after angiography. Control subjects received saline only. Serum creatinine was measured before and three days after coronary angiography.
  
  
  RESULTS
  There was no significant difference between intervention and control groups at baseline (P > 0.05). However, there was a significant decline in creatinine level among NAC patients (P = 0.001). Saline group had significantly higher proportion of nephropathy cases than NAC patients Conclusion: We found that the consumption of NAC is useful for contrast induced nephropathy (CIN) prevention.
authors.affiliation: Zanjan Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan, Iran ; Department of Internal Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Aiyoub
authors.initials: A
authors.lastname: Pezeshgi
authors.affiliation: Department of Internal Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Negin
authors.initials: N
authors.lastname: Parsamanesh
authors.affiliation: Department of Internal Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Goodarz
authors.initials: G
authors.lastname: Farhood
authors.affiliation: Department of Internal Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Khalil
authors.initials: K
authors.lastname: Mahmoodi
keywords: Acute kidney injury; Contrast agents; Contrast induced nephropathy