title: Association of telomere length and mitochondrial DNA copy number with risperidone treatment response in first-episode antipsychotic-naïve schizophrenia.
abstract: Accumulating evidence indicates a putative association of telomere length and mitochondrial function with antipsychotics response in schizophrenia (SCZ). However, pharmacological findings were limited and no previous work has assessed this in a prospective longitudinal study. This study assessed telomere length and mitochondrial DNA copy number in first-episode antipsychotic-naïve SCZ patients with 8-week risperidone treatment to evaluate the association between these biomarkers and clinical treatment response. We recruited 137 first-episode antipsychotic-naive SCZ patients (and 144 controls) at baseline and 89 patients completed the 8-week follow-up. Patients, completed follow-up, were divided into Responders (N = 46) and Non-Responders (N = 43) according to the percentage of symptoms improvement. Linear regression analyses show that SCZ patients had significantly lower mtDNA copy number (β = -0.108, p = 0.002), and no alteration of telomere length when compared with healthy controls. In addition, compared with Non-Responders, Responders had significantly lower mtDNA copy number (β = -0.178, p = 0.001), and longer telomere length (β = 0.111, p = 0.071) before the 8-week treatment. After treatment, Responders persisted lower mtDNA copy number comparing with No-Responders (partial η(2) = 0.125, p = 0.001). These findings suggest that telomere length and mtDNA copy number may hold the potential to serve as predictors of antipsychotic response of SCZ patients.
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, Changsha 410011, China.|The State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, China.
authors.forename: Zongchang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, Changsha 410011, China.
authors.forename: Maolin
authors.initials: M
authors.lastname: Hu
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, Changsha 410011, China.
authors.forename: Xiaofen
authors.initials: X
authors.lastname: Zong
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, Changsha 410011, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: He
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, Changsha 410011, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, Changsha 410011, China.
authors.forename: Lulin
authors.initials: L
authors.lastname: Dai
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, Changsha 410011, China.
authors.forename: Min
authors.initials: M
authors.lastname: Dong
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, Changsha 410011, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Unit on Statistical Genomics, National Institute of Mental Health, NIH, Bethesda 20892, USA.
authors.forename: Hongbao
authors.initials: H
authors.lastname: Cao
authors.affiliation: Department of Psychiatry, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.
authors.forename: Luxian
authors.initials: L
authors.lastname: Lv
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, Changsha 410011, China.|The State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, China.|The National Clinical Research Center for Psychiatric and Psychological Diseases, Changsha, China.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Chen
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, Changsha 410011, China.|Unit on Statistical Genomics, National Institute of Mental Health, NIH, Bethesda 20892, USA.|The National Clinical Research Center for Psychiatric and Psychological Diseases, Changsha, China.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Tang
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D004272:DNA, Mitochondrial / Q000378:metabolism*; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D018628:Gene Dosage; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008928:Mitochondria / Q000235:genetics; D011446:Prospective Studies; D060888:Real-Time Polymerase Chain Reaction; D018967:Risperidone / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy*; D016615:Telomere / Q000378:metabolism*; D059506:Telomere Shortening; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D004272:DNA, Mitochondrial; D018967:Risperidone