title: Radiolabelling with isotopic mixtures of (52g/55)Mn(II) as a straight route to stable manganese complexes for bimodal PET/MR imaging.
abstract: Radiolabelling using isotopic mixtures of (52g/55)Mn(ii) offers fast and easy access to new small molecule PET/MR tracers, composed of chemically identical reporting units. trans-1,2-Diaminocyclohexane-N,N,N',N'-tetraacetic acid (CDTA) was radiolabelled with carrier-added (52g)Mn(ii) in >99% radiochemical yield, producing the first manganese-based bimodal PET/MR probe. The Mn-CDTA chelate was shown to be very stable to air oxidation and sufficiently inert to decomplexation in blood serum. These data sparked our interest in functionalized CDTA ligands for the design of optimized PET/MR tracers.
authors.affiliation: Institut für Neurowissenschaften und Medizin, INM-5: Nuklearchemie, Forschungszentrum Jülich GmbH, D-52425 Jülich, Germany. c.vanasschen@fz-juelich.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Vanasschen
authors.affiliation: Institut für Neurowissenschaften und Medizin, INM-5: Nuklearchemie, Forschungszentrum Jülich GmbH, D-52425 Jülich, Germany. c.vanasschen@fz-juelich.de.
authors.forename: Marie
authors.initials: M
authors.lastname: Brandt
authors.affiliation: Institut für Neurowissenschaften und Medizin, INM-5: Nuklearchemie, Forschungszentrum Jülich GmbH, D-52425 Jülich, Germany. c.vanasschen@fz-juelich.de.
authors.forename: Johannes
authors.initials: J
authors.lastname: Ermert
authors.affiliation: Institut für Neurowissenschaften und Medizin, INM-5: Nuklearchemie, Forschungszentrum Jülich GmbH, D-52425 Jülich, Germany. c.vanasschen@fz-juelich.de.
authors.forename: Heinz H
authors.initials: HH
authors.lastname: Coenen
mesh_terms: D004492:Edetic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000737:chemistry*; D008968:Molecular Conformation; D015335:Molecular Probes / Q000737:chemistry*; D049268:Positron-Emission Tomography; D011868:Radioisotopes
chemical_list: D015335:Molecular Probes; D011868:Radioisotopes; D008345:Manganese; C005390:CDTA; D004492:Edetic Acid