title: Detection of macrolide resistant Mycoplasma pneumoniae in England, September 2014 to September 2015.
abstract: Mycoplasma pneumoniae infection can cause pneumonia, particularly in children. Global increase in macrolide-resistant M. pneumoniae is of concern due to limited therapeutic options. We describe the detection of macrolide resistance-conferring mutations in 9.3% of 43 clinical specimens where M. pneumoniae was detected in England and Wales from September 2014‒September 2015. This study aims to impact by highlighting the presence of macrolide resistance in M. pneumoniae positive patients, promoting increased clinical vigilance.
authors.affiliation: Bacteriology Reference Department, Public Health England (PHE), London, United Kingdom.
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Brown
authors.forename: Louissa
authors.initials: L
authors.lastname: Macfarlane-Smith
authors.forename: Sarah
authors.initials: S
authors.lastname: Phillips
authors.forename: Victoria J
authors.initials: VJ
authors.lastname: Chalker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004739:England; D005260:Female; D006801:Humans; D018942:Macrolides / Q000627:therapeutic use*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009177:Mycoplasma pneumoniae / Q000187:drug effects* / Q000235:genetics; D011019:Pneumonia, Mycoplasma / Q000175:diagnosis / Q000188:drug therapy*; D016133:Polymerase Chain Reaction; D014852:Wales; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides
keywords: antimicrobial resistance pneumonia Mycoplasma pneumoniae Macrolide