title: Urine Galactomannan-to-Creatinine Ratio for Detection of Invasive Aspergillosis in Patients with Hematological Malignancies.
abstract: Galactomannan (GM) testing of urine specimens may provide important advantages, compared to serum testing, such as easy noninvasive sample collection. We evaluated a total of 632 serial urine samples from 71 patients with underlying hematological malignancies and found that the urine GM/creatinine ratio, i.e., (urine GM level × 100)/urine creatinine level, which takes urine dilution into account, reliably detected invasive aspergillosis and may be a promising diagnostic tool for patients with hematological malignancies. (This study has been registered at ClinicalTrials.gov under registration no. NCT01576653.).
authors.affiliation: Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Frederike M J
authors.initials: FM
authors.lastname: Reischies
authors.affiliation: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria martin.hoenigl@medunigraz.at reinhard.raggam@medunigraz.at.
authors.forename: Reinhard B
authors.initials: RB
authors.lastname: Raggam
authors.affiliation: Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Juergen
authors.initials: J
authors.lastname: Prattes
authors.affiliation: Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Robert
authors.initials: R
authors.lastname: Krause
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Susanne
authors.initials: S
authors.lastname: Eigl
authors.affiliation: Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Agnes
authors.initials: A
authors.lastname: List
authors.affiliation: Institute for Medical Informatics, Statistics, and Documentation, Medical University of Graz, Graz, Austria.
authors.forename: Franz
authors.initials: F
authors.lastname: Quehenberger
authors.affiliation: Division of Pediatric Hemato-Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Volker
authors.initials: V
authors.lastname: Strenger
authors.affiliation: Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Albert
authors.initials: A
authors.lastname: Wölfler
authors.affiliation: Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, Graz, Austria Division of Infectious Diseases, Department of Medicine, University of California, San Diego, California, USA martin.hoenigl@medunigraz.at reinhard.raggam@medunigraz.at.
authors.forename: Martin
authors.initials: M
authors.lastname: Hoenigl
mesh_terms: D001228:Aspergillosis / Q000175:diagnosis / Q000209:etiology* / Q000652:urine*; D015415:Biomarkers; D003404:Creatinine / Q000097:blood / Q000652:urine*; D005260:Female; D005690:Galactose / Q000031:analogs & derivatives; D019337:Hematologic Neoplasms / Q000150:complications*; D006801:Humans; D008297:Male; D008351:Mannans / Q000097:blood / Q000652:urine*; D008875:Middle Aged; D012372:ROC Curve; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D008351:Mannans; C012990:galactomannan; D003404:Creatinine; D005690:Galactose