title: Epigenetic dysregulation in follicular lymphoma.
abstract: The adoption of next-generation sequencing technologies has led to a remarkable shift in our understanding of the genetic landscape of follicular lymphoma. While the disease has been synonymous with the t(14;18), the prevalence of alterations in genes that regulate the epigenome has been established as a pivotal hallmark of these lymphomas. Giant strides are being made in unraveling the biological consequences of these alterations in tumorigenesis opening up new opportunities for directed therapies.
authors.affiliation: Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
authors.forename: Shamzah
authors.initials: S
authors.lastname: Araf
authors.affiliation: Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
authors.forename: Jessica
authors.initials: J
authors.lastname: Okosun
authors.affiliation: Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
authors.forename: Lola
authors.initials: L
authors.lastname: Koniali
authors.affiliation: Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
authors.forename: Jude
authors.initials: J
authors.lastname: Fitzgibbon
authors.affiliation: Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
authors.forename: James
authors.initials: J
authors.lastname: Heward
mesh_terms: D000107:Acetylation; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006657:Histones / Q000378:metabolism; D006801:Humans; D008224:Lymphoma, Follicular / Q000235:genetics*
chemical_list: D006657:Histones
keywords: CREBBP; EP300; EZH2; KMT2D; epigenetics; follicular lymphoma; histone acetylation; histone methylation; noncoding RNA