title: Circulating maternal cortisol levels during vaginal delivery and elective cesarean section.
abstract: Maternal S-cortisol levels increase throughout pregnancy and peak in the third trimester. Even higher levels are seen during the physical stress of delivery. Since analgesia for women in labor has improved, it is possible that maternal stress during labor is reduced. The aim of this study was to compare maternal S-cortisol during vaginal delivery and elective cesarean section.
  
  
  
  Twenty healthy women with spontaneous vaginal delivery and healthy women (n = 20) undergoing elective cesarean section were included in the study. S-cortisol was measured during three stages of spontaneous vaginal delivery (tvd1, tvd2 and tvd3), as well as before and after elective cesarean section (tcs1 and tcs2).
  
  
  
  In the vaginal delivery group, mean S-cortisol at tvd1 was 1325 ± 521 nmol/L, at tvd2 1559 ± 591 nmol/L and at tvd3 1368 ± 479 nmol/L. In the cesarean section group, mean S-cortisol at tcs1 was 906 ± 243 nmol/L and at tcs2 831 ± 257 nmol/L. S-cortisol was higher in the vaginal delivery group at the onset of labor as compared to the cesarean section preoperative group (p = 0.006). There were also significant differences between S-cortisol levels postpartum as compared to postoperatively (p < 0.001).
  
  
  
  Maternal S-cortisol was higher during vaginal delivery compared to elective cesarean section, indicating higher stress levels. A reduction in the hydrocortisone dose at childbirth in women with adrenal insufficiency should be considered, particularly in women undergoing an elective cesarean section.
authors.affiliation: Department of Women's and Children's Health, Karolinska Institute and Karolinska University Hospital, 171 76, Stockholm, Sweden. ylva.vladic-stjernholm@karolinska.se.
authors.forename: Ylva Vladic
authors.initials: YV
authors.lastname: Stjernholm
authors.affiliation: Medical School, Karolinska Institute, Stockholm, Sweden.
authors.forename: Annie
authors.initials: A
authors.lastname: Nyberg
authors.affiliation: Department of Women's and Children's Health, Skåne University Hospital, Lund, Sweden.
authors.forename: Monica
authors.initials: M
authors.lastname: Cardell
authors.affiliation: Department of Endocrinology, Metabolism and Diabetology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Höybye
mesh_terms: D000328:Adult; D002585:Cesarean Section; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007743:Labor, Obstetric; D036801:Parturition; D011247:Pregnancy; D055815:Young Adult
chemical_list: D006854:Hydrocortisone
keywords: Cesarean section; Cortisol; Delivery; Stress