title: Assessment of Renal Hemodynamics and Oxygenation by Simultaneous Magnetic Resonance Imaging (MRI) and Quantitative Invasive Physiological Measurements.
abstract: In vivo assessment of renal perfusion and oxygenation under (patho)physiological conditions by means of noninvasive diagnostic imaging is conceptually appealing. Blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) and quantitative parametric mapping of the magnetic resonance (MR) relaxation times T 2* and T 2 are thought to provide surrogates of renal tissue oxygenation. The validity and efficacy of this technique for quantitative characterization of local tissue oxygenation and its changes under different functional conditions have not been systematically examined yet and remain to be established. For this purpose, the development of an integrative multimodality approaches is essential. Here we describe an integrated hybrid approach (MR-PHYSIOL) that combines established quantitative physiological measurements with T 2* (T 2) mapping and MR-based kidney size measurements. Standardized reversible (patho)physiologically relevant interventions, such as brief periods of aortic occlusion, hypoxia, and hyperoxia, are used for detailing the relation between the MR-PHYSIOL parameters, in particular between renal T 2* and tissue oxygenation.
authors.affiliation: Institute of Physiology, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.|Center for Cardiovascular Research, Berlin, Germany.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Cantow
authors.affiliation: Institute of Physiology, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.|Center for Cardiovascular Research, Berlin, Germany.
authors.forename: Karen
authors.initials: K
authors.lastname: Arakelyan
authors.affiliation: Institute of Physiology, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.|Center for Cardiovascular Research, Berlin, Germany.
authors.forename: Erdmann
authors.initials: E
authors.lastname: Seeliger
authors.affiliation: Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
authors.forename: Thoralf
authors.initials: T
authors.lastname: Niendorf
authors.affiliation: Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany. andreas.pohlmann@mdc-berlin.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Pohlmann
mesh_terms: D000818:Animals; D006439:Hemodynamics; D000860:Hypoxia / Q000378:metabolism; D007090:Image Interpretation, Computer-Assisted; D007091:Image Processing, Computer-Assisted; D007668:Kidney / Q000033:anatomy & histology / Q000098:blood supply* / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D023421:Models, Animal; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D051381:Rats; D012079:Renal Circulation
chemical_list: D010100:Oxygen
keywords: Blood oxygenation level dependent (BOLD); Hyperoxia; Hypoxia; Magnetic resonance imaging (MRI); Oxygenation; Perfusion; Rats