title: Vascular cognitive impairment and dementia.
abstract: Vascular contributions to cognitive impairment are receiving heightened attention as potentially modifiable factors for dementias of later life. These factors have now been linked not only to vascular cognitive disorders but also Alzheimer's disease. In this chapter we review 3 related topics that address vascular contributions to cognitive impairment: 1. vascular pathogenesis and mechanisms; 2. neuropsychological and neuroimaging phenotypic manifestations of cerebrovascular disease; and 3. prospects for prevention of cognitive impairment of later life based on cardiovascular and stroke risk modification. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.
authors.affiliation: Translational Science & Molecular Medicine, Michigan State University College of Human Medicine, Mercy Health Hauenstein Neurosciences, 220 Cherry Street SE, Grand Rapids, MI 49503, USA. Electronic address: pgorelic@mercyhealth.com.
authors.forename: Philip B
authors.initials: PB
authors.lastname: Gorelick
authors.affiliation: Translational Science & Molecular Medicine and Family Medicine, Michigan State University College of Human Medicine, Mercy Health Hauenstein Neurosciences, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA.
authors.forename: Scott E
authors.initials: SE
authors.lastname: Counts
authors.affiliation: Translational Science & Molecular Medicine, Michigan State University College of Human Medicine, Neuropsychology Program, Mercy Health Hauenstein Neurosciences, 220 Cherry Street SE, Grand Rapids, MI 49503, USA.
authors.forename: David
authors.initials: D
authors.lastname: Nyenhuis
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000473:pathology*; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000517:prevention & control; D015140:Dementia, Vascular / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000517:prevention & control; D006801:Humans; D059906:Neuroimaging; D009483:Neuropsychological Tests; D012307:Risk Factors
keywords: Pathophysiologic mechanisms; Prevention; Stroke; Vascular cognitive impairment