title: [Long-term efficacy of triple semicircular canal occlusion in the treatment of intractable Meniere's disease].
abstract: OBJECTIVE
  To explore the long-term efficacy and safety of triple semicircular canal occlusion (TSCO) in the treatment of intractable Meniere's disease (MD) so as to provide an alternative surgical procedure for treating this disorder.
  
  
  METHODS
  Data from Forty-nine patients, who were referred to our hospital and diagnosed with unilateral MD strictly meeting the criteria issued by Chinese Academy of Otolaryngology-Head and Neck Surgery Committee (2006) from Dec. 2010 to Jul. 2012, were retrospectively analyzed in this work. Forty-nine patients, in whom the standardized conservative treatment was given at least one year and frequent vertigo still occurred, received TSCO. Vertigo control and auditory function were measured. Pure tone audiometry, caloric test, and cervical vestibular evoked myogenic potential (cVEMP) were performed for evaluation of audiological and vestibular function. Magnetic resonance hydrograph of inner ear was performed in patients received TSCO after 2 years for the observation of morphology of membranous labyrinth. Postoperative follow-up period was more than 2 years.
  
  
  RESULTS
  According to the preoperative staging of hearing, among these 49 patients, there were 2 cases in stage II (with an average hearing threshold of 25-40 dBHL), 40 in stage III (41-70 dBHL) and 7 in stage IV (over 70 dBHL). Vertigo was controlled effectively in all 49 cases in two-year follow-up, of which 40 cases (81.6%) were completely controlled and 9 cases (18.4%) were substantially controlled after surgery. The rate of hearing preservation was 69.4% and the rate of hearing loss was 30.6%. Post-operatively, all patients suffered from temporary vertigo and balance disorders. Vertigo was disappeared in all patients within 3-5 days, while averagely recovered after 13.5 days. Two years afer treatment, loss of semicircular canal function by caloric test was found in the operation side of all patients and no change in cVEMP test was noted. All patients had no facial paralysis, cerebrospinal fluid leakage, and other complications. Magnetic resonance hydrograph of inner ear showed that endolymph fluid in the position of plugging had no water after 2-years of TSCO.
  
  
  CONCLUSIONS
  TSCO, which can reduce vertiginous symptoms effectively in patients with intractable MD in long-term follow-up, represents an effective and safe therapy for this disorder. TSCO is expected to be used as an alternative procedure for the treatment of MD in selected patients suffering from severe hearing loss or recurrence after endolymphatic sac surgery.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Provincial Hospital affiliated to Shandong University, Shandong Provincial Key Laboratory of Otology, Jinan 250021, China.
authors.forename: Daogong
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Provincial Hospital affiliated to Shandong University, Shandong Provincial Key Laboratory of Otology, Jinan 250021, China.
authors.forename: Zhaomin
authors.initials: Z
authors.lastname: Fan
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Provincial Hospital affiliated to Shandong University, Shandong Provincial Key Laboratory of Otology, Jinan 250021, China.
authors.forename: Yuechen
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Provincial Hospital affiliated to Shandong University, Shandong Provincial Key Laboratory of Otology, Jinan 250021, China.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Provincial Hospital affiliated to Shandong University, Shandong Provincial Key Laboratory of Otology, Jinan 250021, China; Email: whbotologic797@163.com.
authors.forename: Haibo
authors.initials: H
authors.lastname: Wang
mesh_terms: D001301:Audiometry, Pure-Tone; D002150:Caloric Tests; D004710:Endolymph; D005500:Follow-Up Studies; D006309:Hearing; D034381:Hearing Loss / Q000628:therapy; D006801:Humans; D008575:Meniere Disease / Q000601:surgery*; D013506:Otologic Surgical Procedures / Q000379:methods*; D012008:Recurrence; D012189:Retrospective Studies; D012665:Semicircular Canals / Q000601:surgery*; D014717:Vertigo / Q000628:therapy; D058585:Vestibular Evoked Myogenic Potentials