title: High inspired oxygen versus low inspired oxygen for reducing surgical site infection: a meta-analysis.
abstract: To perform a meta-analysis of published literature to assess the role of high-concentration inspired oxygen in reducing the incidence of surgical site infections (SSIs) following all types of surgery, a comprehensive search for published randomized controlled trials (RCTs) comparing high- with low-concentration inspired oxygen for SSIs was performed. The related data were extracted by two independent authors. The fixed and random effects methods were used to combine data. Twelve RCTs involving 6750 patients were included. Our pooled result found that no significant difference in the incidence of SSIs was observed between the two groups, but there was high statistic heterogeneity across the studies [risk ratio (RR): 0·91; 95% confidence interval (CI): 0·72-1·14; P = 0·40; I2= 54%]. The sensitivity analysis revealed the superiority of high-concentration oxygen in decreasing the SSI rate (RR: 0·86; 95% CI: 0·75-0·98; P = 0·02). Moreover, a subgroup analysis of studies with intestinal tract surgery showed that patients experienced less SSI when high-concentration inspired oxygen was administrated (RR: 0·53; 95% CI: 0·37-0·74; P = 0·0003). Our study provided no direct support for high-concentration inspired oxygen in reducing the incidence of SSIs in patients undergoing all types of surgery.
authors.affiliation: Department of Obstetrics and Gynecology, Shengli Oilfield Central Hospital, Dongying, China.
authors.forename: Hongye
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Intensive Care Unit, Shengli Oilfield Central Hospital, Dongying, China.
authors.forename: Shukun
authors.initials: S
authors.lastname: Hong
authors.affiliation: Department of Obstetrics and Gynecology, Shengli Oilfield Central Hospital, Dongying, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, Shengli Oilfield Central Hospital, Dongying, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Duan
authors.affiliation: Department of Obstetrics and Gynecology, Shengli Oilfield Central Hospital, Dongying, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Yin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage*; D018570:Risk Assessment / Q000706:statistics & numerical data*; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000628:therapy*
chemical_list: D010100:Oxygen
keywords: Meta-analysis; Perioperative period; Supplemental oxygen; Surgical site infection