title: Transition-Metal-Free CO-Releasing BODIPY Derivatives Activatable by Visible to NIR Light as Promising Bioactive Molecules.
abstract: Carbon monoxide-releasing molecules (CORMs) are chemical agents used to administer CO as an endogenous, biologically active molecule. A precise spatial and temporal control over the CO release is the major requirement for their applications. Here, we report the synthesis and properties of a new generation of transition-metal-free carbon monoxide-releasing molecules based on BODIPY chromophores (COR-BDPs) activatable by visible-to-NIR (up to 730 nm) light. We demonstrate their performance for both in vitro and in vivo experimental settings, and we propose the mechanism of the CO release based on steady-state and transient spectroscopy experiments and quantum chemical calculations.
authors.affiliation: Department of Chemistry and RECETOX, Masaryk University , Kamenice 5, 625 00 Brno, Czech Republic.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Palao
authors.affiliation: Department of Chemistry and RECETOX, Masaryk University , Kamenice 5, 625 00 Brno, Czech Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Slanina
authors.forename: Lucie
authors.initials: L
authors.lastname: Muchová
authors.affiliation: Department of Chemistry and RECETOX, Masaryk University , Kamenice 5, 625 00 Brno, Czech Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Šolomek
authors.forename: Libor
authors.initials: L
authors.lastname: Vítek
authors.affiliation: Department of Chemistry and RECETOX, Masaryk University , Kamenice 5, 625 00 Brno, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Klán
mesh_terms: D001896:Boron Compounds / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry*; D007259:Infrared Rays; D028561:Transition Elements / Q000737:chemistry*
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D028561:Transition Elements; D002248:Carbon Monoxide