title: Finding the Middlemen in Genome Organization.
abstract: Chromatin domains associated with the nuclear lamina are generally heterochromatic and transcriptionally repressed. How they are recruited to and maintained at the nuclear periphery remains unclear. A recent study by Gonzalez-Sandoval et al. (2015) in Cell identifies a chromatin-binding protein that links repressive chromatin with the inner nuclear membrane.
authors.affiliation: Department of Biological Chemistry, Center for Epigenetics, Johns Hopkins University, 855 N. Wolfe Street, Baltimore, MD 21205, USA.
authors.forename: Xianrong
authors.initials: X
authors.lastname: Wong
authors.affiliation: Department of Biological Chemistry, Center for Epigenetics, Johns Hopkins University, 855 N. Wolfe Street, Baltimore, MD 21205, USA. Electronic address: kreddy4@jhmi.edu.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Reddy
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D004625:Embryo, Nonmammalian / Q000166:cytology*; D006570:Heterochromatin; D042421:Histone Code
chemical_list: D029742:Caenorhabditis elegans Proteins; D002868:Chromosomal Proteins, Non-Histone; D006570:Heterochromatin