title: Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications.
abstract: Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriving clinical implications.
authors.affiliation: Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK ; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
authors.forename: Fizzah Aziz
authors.initials: FA
authors.lastname: Choudry
authors.affiliation: Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK ; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK ; British Heart Foundation Centre of Excellence, University of Cambridge, Cambridge CB2 0QQ, UK.
authors.forename: Mattia
authors.initials: M
authors.lastname: Frontini