title: Deregulation of paralogous 13 HOX genes in oral squamous cell carcinoma.
abstract: Many oncogenic drivers related to the pathogenesis of OSCC have identified, but the discovery of new molecular markers for early detection of this cancer, remains one the main goals of clinical research. HOX genes regulate normal embryonic development, cell differentiation and other critical processes in eukaryotic cell life. Several studies have demonstrated that the deregulation of HOX genes play a significant role in cancer development and progression. In this study, we built a prognostic TMA with 119 OSCC samples, representative of deep and superficial part of the tumour, to investigate, the paralogous 13 HOX proteins expression, correlating them with clinicpathological parameters, outcomes and therapy information. Our results show an aberrant expression of HOX A13 and HOX D13 in OSCC pathogenesis and tumour progression. HOX A13 overexpression is related to an OSCC better prognosis (P=0.029) and better therapy response in patients treated with both radiotherapy and chemotherapy (P=0.015). HOX D13 overexpression is inversely related to an overall survival (P=0.004). These data highlight the potential prognostic role of HOX paralogous group 13 genes in OSCC.
authors.affiliation: Department of Pathology, Istituto Nazionale Tumori "Fondazione Pascale"-IRCCS via Mariano Semmola, Napoli 80131, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Aquino
authors.affiliation: Department of Pathology, Istituto Nazionale Tumori "Fondazione Pascale"-IRCCS via Mariano Semmola, Napoli 80131, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Franco
authors.affiliation: Department of Pathology, Istituto Nazionale Tumori "Fondazione Pascale"-IRCCS via Mariano Semmola, Napoli 80131, Italy.
authors.forename: Rocco
authors.initials: R
authors.lastname: Sabatino
authors.affiliation: Department of Pathology, Istituto Nazionale Tumori "Fondazione Pascale"-IRCCS via Mariano Semmola, Napoli 80131, Italy.
authors.forename: Elvira La
authors.initials: EL
authors.lastname: Mantia
authors.affiliation: Department of Pathology, Istituto Nazionale Tumori "Fondazione Pascale"-IRCCS via Mariano Semmola, Napoli 80131, Italy.
authors.forename: Giosuè
authors.initials: G
authors.lastname: Scognamiglio
authors.affiliation: Department of Pathology, Istituto Nazionale Tumori "Fondazione Pascale"-IRCCS via Mariano Semmola, Napoli 80131, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Collina
authors.affiliation: Department of Head and Neck Medical Oncology, Istituto Nazionale Tumori "Fondazione Pascale"-IRCCS via Mariano Semmola, Napoli 80131, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Longo
authors.affiliation: Department of Head and Neck Medical Oncology, Istituto Nazionale Tumori "Fondazione Pascale"-IRCCS via Mariano Semmola, Napoli 80131, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Ionna
authors.affiliation: Department of Pathology, Istituto Nazionale Tumori "Fondazione Pascale"-IRCCS via Mariano Semmola, Napoli 80131, Italy.
authors.forename: Nunzia S
authors.initials: NS
authors.lastname: Losito
authors.affiliation: Department of Pathology, Istituto Nazionale Tumori "Fondazione Pascale"-IRCCS via Mariano Semmola, Napoli 80131, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Liguori
authors.affiliation: Department of Pathology, Istituto Nazionale Tumori "Fondazione Pascale"-IRCCS via Mariano Semmola, Napoli 80131, Italy.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Botti
authors.affiliation: Department of Pathology, Istituto Nazionale Tumori "Fondazione Pascale"-IRCCS via Mariano Semmola, Napoli 80131, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Cantile
keywords: OSCC; Paralogous 13 HOX genes; tumour progression