title: Callistrilones A and B, Triketone-Phloroglucinol-Monoterpene Hybrids with a New Skeleton from Callistemon rigidus.
abstract: The first triketone-phloroglucinol-monoterpene hybrids, callistrilones A and B (1 and 2), along with a postulated biosynthetic intermediate (3) were isolated from the leaves of Callistemon rigidus. Compounds 1 and 2 featured a new carbon skeleton with an unprecedented [1]benzofuro[2,3-a]xanthene or [1]benzofuro[3,2-b]xanthene pentacyclic ring system composed of three kinds of building blocks. Their structures and absolute configurations were elucidated by spectroscopic analysis, X-ray diffraction, and electronic circular dichroism (ECD) calculations. A plausible biogenetic pathway for the new compounds is also proposed. Compound 1 exhibited moderate antibacterial activity against Gram-positive bacteria including multiresistant strains.
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Jia-Qing
authors.initials: JQ
authors.lastname: Cao
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Huang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Li
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Ren-Wang
authors.initials: RW
authors.lastname: Jiang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D016984:Enterococcus faecium / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027822:Myrtaceae / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D039821:Monoterpenes; C000607862:callistrilone A; C000607863:callistrilone B; D010696:Phloroglucinol