title: Female sex steroids and glia cells: Impact on multiple sclerosis lesion formation and fine tuning of the local neurodegenerative cellular network.
abstract: Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease that shows a female-to-male gender prevalence and alleviation of disease activity during late stage pregnancy. In MS-related animal models, sex steroids ameliorate symptoms and protect from demyelination and neuronal damage. Underlying mechanisms of these protective avenues are continuously discovered, in part by using novel transgenic animal models. In this review article, we highlight the regulation of glia cell function by female sex steroids. We specifically focus on the relevance of glia cells for immune cell recruitment into the central nervous system and show how estrogen and progesterone can modulate these cell-cell communication pathways. Since MS is considered to have a strong neurodegenerative component, principal neuroprotective mechanisms, exerted by sex-steroids will be discussed as well. Activation of steroid receptors might not just act as immunosuppressant but at the same time harmonize brain-intrinsic networks to dampen neurodegeneration and, thus, disease progression in MS.
authors.affiliation: Department of Neuroanatomy, Ludwig-Maximilians-University of Munich, Munich, Germany. Electronic address: markus.kipp@med.uni-muenchen.de.
authors.forename: Markus
authors.initials: M
authors.lastname: Kipp
authors.affiliation: Department of Neuroanatomy, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Hochstrasser
authors.affiliation: Department of Neuroanatomy, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Schmitz
authors.affiliation: Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
authors.forename: Cordian
authors.initials: C
authors.lastname: Beyer
mesh_terms: D000818:Animals; D005260:Female; D012739:Gonadal Steroid Hormones; D006801:Humans; D009103:Multiple Sclerosis; D009457:Neuroglia; D018696:Neuroprotective Agents; D011247:Pregnancy; D011374:Progesterone
chemical_list: D012739:Gonadal Steroid Hormones; D018696:Neuroprotective Agents; D011374:Progesterone
keywords: Astroglia; Estrogen; Immune cells; Inflammation; Invasion; Microglia; Multiple sclerosis; Neuroinflammation; Neuroprotection; Progesterone