title: The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain.
abstract: We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways.
authors.affiliation: Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Ren
authors.affiliation: Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Maria Virginia
authors.initials: MV
authors.lastname: Centeno
authors.affiliation: Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Berger
authors.affiliation: Pain Research Center and Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Pain Research Center and Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Na
authors.affiliation: Pain Research Center and Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Xianguo
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Jyothisri
authors.initials: J
authors.lastname: Kondapalli
authors.affiliation: Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: A Vania
authors.initials: AV
authors.lastname: Apkarian
authors.affiliation: Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Marco
authors.initials: M
authors.lastname: Martina
authors.affiliation: Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: D James
authors.initials: DJ
authors.lastname: Surmeier
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D019706:Excitatory Postsynaptic Potentials; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009288:Naproxen / Q000494:pharmacology; D009434:Neural Pathways / Q000378:metabolism / Q000503:physiopathology*; D009437:Neuralgia / Q000378:metabolism / Q000503:physiopathology* / Q000523:psychology; D009474:Neurons / Q000473:pathology; D009714:Nucleus Accumbens / Q000033:anatomy & histology* / Q000378:metabolism / Q000503:physiopathology*; D010147:Pain Measurement; D059348:Peripheral Nerve Injuries / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012919:Social Behavior; D013569:Synapses / Q000473:pathology
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen