title: Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling.
abstract: Caffeine is a widely used psychoactive substance. Studies have shown that caffeine may play a protective role in aging-associated disorders. However, the mechanisms by which caffeine modulates aging are not yet clear. In this study, we have shown that caffeine increases Caenorhabditis elegans lifespan, delays its larval development, reduces reproduction and body length. These phenotypes were partly reversed by worm's exposure to adenosine, which suggest a putative common target. Moreover, they were dependent on a functional insulin/IGF-1-like pathway. Our results may shed light on new genetic determinants of aging.
authors.affiliation: Departamento de Saúde Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais Belo Horizonte, Brazil ; Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais Belo Horizonte, Brazil.
authors.forename: Jessika Cristina
authors.initials: JC
authors.lastname: Bridi
authors.affiliation: Departamento de Saúde Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais Belo Horizonte, Brazil ; Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais Belo Horizonte, Brazil.
authors.forename: Alexandre Guimarães de Almeida
authors.initials: AG
authors.lastname: Barros
authors.affiliation: Departamento de Saúde Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais Belo Horizonte, Brazil ; Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais Belo Horizonte, Brazil.
authors.forename: Letícia Reis
authors.initials: LR
authors.lastname: Sampaio
authors.affiliation: Departamento de Saúde Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais Belo Horizonte, Brazil ; Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais Belo Horizonte, Brazil.
authors.forename: Júlia Castro Damásio
authors.initials: JC
authors.lastname: Ferreira
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Centro de CiênciasNaturais e Exatas, Universidade Federal de Santa Maria Santa Maria, Brazil.
authors.forename: Felix Alexandre
authors.initials: FA
authors.lastname: Antunes Soares
authors.affiliation: Departamento de Saúde Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais Belo Horizonte, Brazil ; Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais Belo Horizonte, Brazil.
authors.forename: Marco Aurélio
authors.initials: MA
authors.lastname: Romano-Silva
keywords: Caenorhabditis elegans; adenosine; caffeine; insulin/IGF-1 pathway; lifespan