title: Ex vivo lung perfusion.
abstract: Lung transplantation is an established life-saving therapy for patients with end-stage lung disease. Unfortunately, greater success in lung transplantation is hindered by a shortage of lung donors and the relatively poor early-, mid-, and long-term outcomes associated with severe primary graft dysfunction. Ex vivo lung perfusion has emerged as a modern preservation technique that allows for a more accurate lung assessment and improvement in lung quality. This review outlines the: (i) rationale behind the method; (ii) techniques and protocols; (iii) Toronto ex vivo lung perfusion method; (iv) devices available; and (v) clinical experience worldwide. We also highlight the potential of ex vivo lung perfusion in leading a new era of lung preservation.
authors.affiliation: Division of Thoracic Surgery, Toronto Lung Transplant Program, University of Toronto and Toronto Lung Transplant Program, Latner Thoracic Surgery Research Laboratories, Toronto, ON, Canada.
authors.forename: Jeremie
authors.initials: J
authors.lastname: Reeb
authors.affiliation: Division of Thoracic Surgery, Toronto Lung Transplant Program, University of Toronto and Toronto Lung Transplant Program, Latner Thoracic Surgery Research Laboratories, Toronto, ON, Canada.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Cypel
mesh_terms: D064591:Allografts; D005112:Extracorporeal Circulation; D006801:Humans; D008168:Lung / Q000502:physiology*; D010477:Perfusion
keywords: donation after cardiac death; ex vivo lung perfusion; lung assessment/reconditioning/repair; lung transplantation; marginal donor lung; organ preservation; organ procurement; primary graft dysfunction