title: Biocompatible cellulose-based superabsorbent hydrogels with antimicrobial activity.
abstract: Current superabsorbent hydrogels commercially applied in the disposable diapers have disadvantages such as weak mechanical strength, poor biocompatibility, and lack of antimicrobial activity, which may induce skin allergy of body. To overcome these hassles, we have developed novel cellulose based hydrogels via simple chemical cross-linking of quaternized cellulose (QC) and native cellulose in NaOH/urea aqueous solution. The prepared hydrogel showed superabsorbent property, high mechanical strength, good biocompatibility, and excellent antimicrobial efficacy against Saccharomyces cerevisiae. The presence of QC in the hydrogel networks not only improved their swelling ratio via electrostatic repulsion of quaternary ammonium groups, but also endowed their antimicrobial activity by attraction of sections of anionic microbial membrane into internal pores of poly cationic hydrogel leading to the disruption of microbial membrane. Moreover, the swelling properties, mechanical strength, and antibacterial activity of hydrogels strongly depended on the contents of quaternary ammonium groups in hydrogel networks. The obtained data encouraged the use of these hydrogels for hygienic application such as disposable diapers.
authors.affiliation: Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Wuhan 430071, China; Guangzhou Sugarcane Industry Research Institute, Guangzhou 510316, China.
authors.forename: Na
authors.initials: N
authors.lastname: Peng
authors.affiliation: Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Wuhan 430071, China.
authors.forename: Yanfeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Wuhan 430071, China. Electronic address: yqf_china@163.com.
authors.forename: Qifa
authors.initials: Q
authors.lastname: Ye
authors.affiliation: Guangzhou Sugarcane Industry Research Institute, Guangzhou 510316, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liang
authors.affiliation: Guangzhou Sugarcane Industry Research Institute, Guangzhou 510316, China.
authors.forename: Yuxing
authors.initials: Y
authors.lastname: An
authors.affiliation: Guangzhou Sugarcane Industry Research Institute, Guangzhou 510316, China.
authors.forename: Qiwei
authors.initials: Q
authors.lastname: Li
authors.affiliation: Guangzhou Sugarcane Industry Research Institute, Guangzhou 510316, China; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China. Electronic address: changcy@whu.edu.cn.
authors.forename: Chunyu
authors.initials: C
authors.lastname: Chang
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002482:Cellulose / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D020100:Hydrogels; D002482:Cellulose
keywords: Antimicrobial activity; Biocompatible; Cellulose hydrogel; Superabsorbent property