title: Transient Aortic Occlusion Augments Collateral Blood Flow and Reduces Mortality During Severe Ischemia due to Proximal Middle Cerebral Artery Occlusion.
abstract: Cerebral collateral circulation provides alternative vascular routes for blood to reach ischemic tissues during stroke. Collateral therapeutics attempt to augment flow through these collateral channels to reduce ischemia and brain damage during acute ischemic stroke. Transient aortic occlusion (TAO) has pre-clinical data suggesting that it can augment collateral blood flow and clinical data suggesting a benefit for patients with moderate cortical strokes. By diverting blood from the periphery towards the cerebral circulation, TAO has the potential to augment primary collateral flow at the circle of Willis and thereby improve outcome even during large, hemispheric strokes. Using proximal middle and anterior cerebral artery occlusion in rats, we demonstrate that TAO reduces mortality and improves collateral blood flow in severely ischemic animals. As such, TAO may be an effective therapy to reduce early mortality during severe ischemia associated with proximal occlusions.
authors.affiliation: Neurochemical Research Unit, Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.|Neuroscience and Mental Health Institute, University of Alberta, 12-127 Clinical Sciences Building, Edmonton, AB, Canada, T6G 2R3.
authors.forename: Gomathi
authors.initials: G
authors.lastname: Ramakrishnan
authors.affiliation: Neurochemical Research Unit, Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
authors.forename: Bin
authors.initials: B
authors.lastname: Dong
authors.affiliation: Neurochemical Research Unit, Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.|Neuroscience and Mental Health Institute, University of Alberta, 12-127 Clinical Sciences Building, Edmonton, AB, Canada, T6G 2R3.
authors.forename: Kathryn G
authors.initials: KG
authors.lastname: Todd
authors.affiliation: Neuroscience and Mental Health Institute, University of Alberta, 12-127 Clinical Sciences Building, Edmonton, AB, Canada, T6G 2R3.|Division of Neurology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
authors.forename: Ashfaq
authors.initials: A
authors.lastname: Shuaib
authors.affiliation: Neurochemical Research Unit, Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. iwinship@ualberta.ca.|Neuroscience and Mental Health Institute, University of Alberta, 12-127 Clinical Sciences Building, Edmonton, AB, Canada, T6G 2R3. iwinship@ualberta.ca.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Winship
mesh_terms: D000818:Animals; D001018:Aortic Diseases / Q000150:complications*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003097:Collateral Circulation / Q000502:physiology*; D004195:Disease Models, Animal; D020244:Infarction, Middle Cerebral Artery / Q000150:complications / Q000401:mortality / Q000628:therapy; D008297:Male; D018613:Microscopy, Confocal; D051381:Rats; D017207:Rats, Sprague-Dawley
keywords: Cerebral blood flow; Collateral blood flow; Collateral therapeutics; Ischemia; Neuroprotection; Stroke