title: Protein Arginine Methylation and Citrullination in Epigenetic Regulation.
abstract: The post-translational modification of arginine residues represents a key mechanism for the epigenetic control of gene expression. Aberrant levels of histone arginine modifications have been linked to the development of several diseases including cancer. In recent years, great progress has been made in understanding the physiological role of individual arginine modifications and their effects on chromatin function. The present review aims to summarize the structural and functional aspects of histone arginine modifying enzymes and their impact on gene transcription. We will discuss the potential for targeting these proteins with small molecules in a variety of disease states.
authors.affiliation: Department of Chemistry, The Scripps Research Institute , 130 Scripps Way, Jupiter, Florida 33458, United States.
authors.forename: Jakob
authors.initials: J
authors.lastname: Fuhrmann
authors.affiliation: Department of Biochemistry and Molecular Pharmacology, UMass Medical School , 364 Plantation Street, Worcester, Massachusetts 01605, United States.|Program in Chemical Biology, UMass Medical School , 364 Plantation Street, Worcester, Massachusetts 01605, United States.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Thompson
mesh_terms: D001120:Arginine / Q000235:genetics / Q000378:metabolism*; D002843:Chromatin / Q000502:physiology; D002956:Citrulline / Q000378:metabolism*; D044127:Epigenesis, Genetic / Q000502:physiology*; D006801:Humans; D008745:Methylation
chemical_list: D002843:Chromatin; D002956:Citrulline; D001120:Arginine