title: High risk HPV testing following treatment for cervical intraepithelial neoplasia.
abstract: OBJECTIVE
  To determine the results of combined cytology and high-risk human papilloma virus (HR HPV) tests at 6 and 18 months postcolposcopy treatment at one Irish colposcopy centre.
  
  
  METHODS
  All women who attended the centre's colposcopy smear clinic for a co-test 6 months (initial test) posttreatment were included in the audit (n = 251).
  
  
  RESULTS
  The results revealed negative HR HPV for 79 % (n = 198) of women tested 6 months after treatment and positive results for 21 % (n = 53). HR HPV testing was more sensitive than cytology and led to early detection of residual disease. No women with negative HR HPV had high-grade cytology.
  
  
  CONCLUSIONS
  HR HPV is more sensitive than cytology for detection of persistent CIN. However, 19 women with positive HR HPV had normal colposcopy with no persistent CIN detected. A national cost-benefit analysis is recommended to determine the value of the second co-test.
authors.affiliation: Women's and Children's Directorate, University Hospital, Newcastle Rd, Galway, Ireland. Maura.molloy@hse.ie.
authors.forename: M
authors.initials: M
authors.lastname: Molloy
authors.affiliation: Women's and Children's Directorate, University Hospital, Newcastle Rd, Galway, Ireland.
authors.forename: R
authors.initials: R
authors.lastname: Comer
authors.affiliation: Women's and Children's Directorate, University Hospital, Newcastle Rd, Galway, Ireland.
authors.forename: P
authors.initials: P
authors.lastname: Rogers
authors.affiliation: School of Nursing and Midwifery, National University of Ireland, University Road, Galway, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: Dowling
authors.affiliation: School of Nursing and Midwifery, National University of Ireland, University Road, Galway, Ireland.
authors.forename: P
authors.initials: P
authors.lastname: Meskell
authors.affiliation: Women's and Children's Directorate, University Hospital, Newcastle Rd, Galway, Ireland.
authors.forename: K
authors.initials: K
authors.lastname: Asbury
authors.affiliation: Women's and Children's Directorate, University Hospital, Newcastle Rd, Galway, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: O'Leary
mesh_terms: D000328:Adult; D003127:Colposcopy / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test / Q000379:methods*; D027383:Papillomaviridae / Q000254:growth & development*; D030361:Papillomavirus Infections / Q000175:diagnosis*; D011247:Pregnancy; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000628:therapy*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000628:therapy*
keywords: Audit; Cervical intraepithelial neoplasia; Colposcopy; HPV DNA tests; Papanicolaou test