title: The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development.
abstract: Appropriate vessel development and its coordinated function is essential for proper embryogenesis and homeostasis in the adult. Defects in vessels cause birth defects and are an important etiology of diseases such as cardiovascular disease, tumor and diabetes retinopathy. The accumulative data indicate that ETV2, an ETS transcription factor, performs a potent and indispensable function in mediating vessel development. This review discusses the recent progress of the study of ETV2 with special focus on its regulatory mechanisms and cell fate determining role in developing mouse embryos as well as somatic cells.
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.|Children's Heart Research and Outcomes Center, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Se-Yeong
authors.initials: SY
authors.lastname: Oh
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.|Children's Heart Research and Outcomes Center, Emory University School of Medicine, Atlanta, GA, USA.|Molecular and Systems Pharmacology Program, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.|Children's Heart Research and Outcomes Center, Emory University School of Medicine, Atlanta, GA, USA.|Molecular and Systems Pharmacology Program, Emory University School of Medicine, Atlanta, GA, USA.|Biochemistry, Cell Biology and Developmental Biology Program, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Changwon
authors.initials: C
authors.lastname: Park
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D065150:Cellular Reprogramming; D047108:Embryonic Development; D042783:Endothelial Cells / Q000166:cytology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D018919:Neovascularization, Physiologic; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: C503994:ER71 protein, mouse; D014157:Transcription Factors
keywords: ETV2; cell reprogramming; endothelial cells; transcription factors