title: Targeting the Hippo pathway: Clinical implications and therapeutics.
abstract: The Hippo pathway plays a critical role in tissue and organ size regulation by restraining cell proliferation and apoptosis under homeostatic conditions. Deregulation of this pathway can promote tumorigenesis in multiple malignant human tumor types, including sarcoma, breast, lung and liver cancers. In this review, we summarize the current understanding of Hippo pathway function, it's role in human cancer, and address the potential of Hippo pathway member proteins as therapeutic targets for a variety of tumors.
authors.affiliation: Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA; University of Pennsylvania Sarcoma Program, Philadelphia, PA, USA.
authors.forename: Shuai
authors.initials: S
authors.lastname: Ye
authors.affiliation: Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA; University of Pennsylvania Sarcoma Program, Philadelphia, PA, USA. Electronic address: karineis@mail.med.upenn.edu.
authors.forename: T S Karin
authors.initials: TS
authors.lastname: Eisinger-Mathason
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D000090683:Hippo Signaling Pathway; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human; D017346:Protein Serine-Threonine Kinases
keywords: Cancer; Hippo; YAP