title: Serological Study on Cytomegalovirus and Toxoplasma Gondii in Thalassemia Major Patients of Yazd, Iran.
abstract: BACKGROUND
  Beta-thalassemia patients receive blood products from blood transfusion centers repeatedly. Blood transfusion can transmit Cytomegalovirus (CMV) and Toxoplasma gondii. The aim of this study was serological evaluation of these two infectious agents in thalassemia patients.
  
  
  METHODS
  In a cross-sectional study, the enzyme-linked immunosorbent assay (ELISA) testing was performed to detect IgM and IgG antibodies against CMV and Toxoplasma gondii in 96 thalassemia patients (under 18 years) and 144 healthy people. Data were analyzed by SPSS software and Chi-square test.
  
  
  RESULTS
  A significant difference was observed in CMVIgM antibody levels between test groups in women (p<0.05). The prevalence of CMV IgM, CMV IgG, Toxo-IgG, and Toxo IgM antibodies in thalassemia patients were 5.2%, 95.9%, 16%, and 0%, respectively.
  
  
  CONCLUSIONS
  In all thalassemia patients, Cytomegalovirus IgG is higher than healthy people. In addition, CMV IgM antibodies are higher in female patients. Antibody screening (IgM) on blood products for detecting Cytomegalovirus is necessary, but for Toxoplasma gondii is not necessary in the Yazd transfusion center.
authors.forename: M
authors.initials: M
authors.lastname: Moghimi
authors.forename: M
authors.initials: M
authors.lastname: Doosti
authors.forename: H A
authors.initials: HA
authors.lastname: Vahedian-Ardakani
authors.forename: A
authors.initials: A
authors.lastname: Talebi
authors.forename: M
authors.initials: M
authors.lastname: Akhavan-Ghalibaf
authors.forename: A
authors.initials: A
authors.lastname: Najafi
authors.forename: M M
authors.initials: MM
authors.lastname: Aminorroaya
authors.forename: Sh
authors.initials: Sh
authors.lastname: Yazdani
authors.forename: M
authors.initials: M
authors.lastname: Shayestehpour
authors.forename: H
authors.initials: H
authors.lastname: Bahrami
authors.forename: F
authors.initials: F
authors.lastname: Khodayari
keywords: Beta-Thalassemia; Cytomegalovirus; ELISA; Toxoplasma