title: S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers.
abstract: This study examined the value of blood marker S100A1 in detecting cardiotoxicity induced by chemotherapy agents; trastuzumab and lapatinib, in normal rat heart. The rats were divided into three groups: control (n = 8, no treatment), T (n = 8, one time ip treatment with 10 mg/kg trastuzumab) and L (n = 8, oral treatment with 100 mg/kg/day lapatinib for 7 days). The activities of oxidative stress parameters Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH) were measured from the extracted cardiac tissues. The levels of troponinI and S100A1 expressions were measured from blood samples. All biomarkers responded to the treatments as they exhibited alterations from their normative values, validating the chemically induced cardiotoxicity. S100A1 expression attenuated significantly (75%), which made the sensitive detection of cardiotoxicity feasible. Assessment of cardiotoxicity with S100A1 may be a valuable alternative in clinical oncology of cancers in some organs such as breast and prostate, as they do not overexpress it to compete against.
authors.affiliation: Department of Cardiology, Medical Faculty, Adnan Menderes University, Aydin, Turkey.
authors.forename: Ufuk
authors.initials: U
authors.lastname: Eryilmaz
authors.affiliation: Department of Medical Pharmacology, Medical Faculty, Adnan Menderes University, Aydin, Turkey.
authors.forename: Buket
authors.initials: B
authors.lastname: Demirci
authors.affiliation: Department of Medical Biochemistry, Medical Faculty, Katip Celebi University, Izmir, Turkey.
authors.forename: Saliha
authors.initials: S
authors.lastname: Aksun
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Adnan Menderes University, Aydin, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Boyacioglu
authors.affiliation: Department of Cardiology, Medical Faculty, Adnan Menderes University, Aydin, Turkey.
authors.forename: Cagdas
authors.initials: C
authors.lastname: Akgullu
authors.affiliation: Department of Cardiology, Konya Selcuklu Private Hospital, Konya, Turkey.
authors.forename: Tevfik Fikret
authors.initials: TF
authors.lastname: Ilgenli
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Adnan Menderes University, Aydin, Turkey.
authors.forename: Hande Sultan
authors.initials: HS
authors.lastname: Yalinkilinc
authors.affiliation: Department of Biophysics, Medical Faculty, Adnan Menderes University, Aydin, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bilgen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000097:blood; D005978:Glutathione / Q000097:blood; D006333:Heart Failure / Q000097:blood* / Q000139:chemically induced; D000077341:Lapatinib; D008297:Male; D008315:Malondialdehyde; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy*; D018384:Oxidative Stress; D011799:Quinazolines / Q000009:adverse effects*; D017208:Rats, Wistar; D009418:S100 Proteins / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood; D000068878:Trastuzumab / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D011799:Quinazolines; D009418:S100 Proteins; C110294:S100A1 protein; D000077341:Lapatinib; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D000068878:Trastuzumab