title: The evolving potential for pediatric ex vivo lung perfusion.
abstract: Despite the rise in the number of adult lung transplantations performed, rates of pediatric lung transplantation remain low. Lung transplantation is an accepted therapy for pediatric end-stage lung disease; however, it is limited by a shortage of donor organs. EVLP has emerged as a platform for assessment and preservation of donor lung function. EVLP has been adopted in adult lung transplantation and has successfully led to increased adult lung transplantations and donor lung utilization. We discuss the future implications of EVLP utilization, specifically, its potential evolving role in overcoming donor shortages in smaller children and adolescents to improve the quality and outcomes of lung transplantation in pediatric patients.
authors.affiliation: Division of Cardiac Surgery, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.|Mazankowski Alberta Heart Institute, Edmonton, AB, Canada.
authors.forename: Jessica G Y
authors.initials: JG
authors.lastname: Luc
authors.affiliation: Division of Cardiac Surgery, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.|Mazankowski Alberta Heart Institute, Edmonton, AB, Canada.|Alberta Transplant Institute, Edmonton, AB, Canada.|Canadian National Transplant Research Program, Edmonton, AB, Canada.
authors.forename: Jayan
authors.initials: J
authors.lastname: Nagendran
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003550:Cystic Fibrosis / Q000601:surgery; D006801:Humans; D008168:Lung / Q000502:physiology*; D008171:Lung Diseases / Q000401:mortality / Q000601:surgery*; D016040:Lung Transplantation / Q000379:methods*; D009929:Organ Size; D010100:Oxygen; D010477:Perfusion / Q000379:methods*; D012129:Respiratory Function Tests; D014019:Tissue Donors / Q000600:supply & distribution; D009927:Tissue and Organ Procurement / Q000379:methods; D016896:Treatment Outcome; D014850:Waiting Lists
chemical_list: D010100:Oxygen
keywords: allograft function; outcome; pediatric lung transplantation