title: Isolation and Synthesis of Laxaphycin B-Type Peptides: A Case Study and Clues to Their Biosynthesis.
abstract: The laxaphyci's B family constitutes a group of five related cyclic lipopeptides isolated from diverse cyanobacteria from all around the world. This group shares a typical structure of 12 amino acids from the l and d series, some of them hydroxylated at the beta position, and all containing a rare beta-amino decanoic acid. Nevertheless, they can be differentiated due to slight variations in the composition of their amino acids, but the configuration of their alpha carbon remains conserved. Here, we provide the synthesis and characterization of new laxaphycin B-type peptides. In doing so we discuss how the synthesis of laxaphycin B and analogues was developed. We also isolate minor acyclic laxaphycins B, which are considered clues to their biosynthesis.
authors.affiliation: Centre de Recherche Insulaire et Observatoire de l'Environnement (CRIOBE), USR 3278 EPHE-CNRS-UPVD, Université de Perpignan Via Domitia, 58 avenue P. Alduy, 66860 Perpignan, France. louis.bornancin@wanadoo.fr.
authors.forename: Louis
authors.initials: L
authors.lastname: Bornancin
authors.affiliation: Centre de Recherche Insulaire et Observatoire de l'Environnement (CRIOBE), USR 3278 EPHE-CNRS-UPVD, Université de Perpignan Via Domitia, 58 avenue P. Alduy, 66860 Perpignan, France. france.boyaud@gmail.com.
authors.forename: France
authors.initials: F
authors.lastname: Boyaud
authors.affiliation: Centre de Recherche Insulaire et Observatoire de l'Environnement (CRIOBE), USR 3278 EPHE-CNRS-UPVD, Université de Perpignan Via Domitia, 58 avenue P. Alduy, 66860 Perpignan, France. zahia.mahiout@hotmail.fr.
authors.forename: Zahia
authors.initials: Z
authors.lastname: Mahiout
authors.affiliation: Centre de Recherche Insulaire et Observatoire de l'Environnement (CRIOBE), USR 3278 EPHE-CNRS-UPVD, Université de Perpignan Via Domitia, 58 avenue P. Alduy, 66860 Perpignan, France. isabelle.bonnard@univ-perp.fr.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bonnard
authors.affiliation: Centre de Recherche Insulaire et Observatoire de l'Environnement (CRIOBE), USR 3278 EPHE-CNRS-UPVD, BP 1013 Papetoai, Moorea, French Polynesia, France. suzanne.mills@univ-perp.fr.|Laboratoire d'Excellence "Corail", 58, avenue Paul Alduy, 66860 Perpignan, France. suzanne.mills@univ-perp.fr.
authors.forename: Suzanne C
authors.initials: SC
authors.lastname: Mills
authors.affiliation: Centre de Recherche Insulaire et Observatoire de l'Environnement (CRIOBE), USR 3278 EPHE-CNRS-UPVD, Université de Perpignan Via Domitia, 58 avenue P. Alduy, 66860 Perpignan, France. banaigs@univ-perp.fr.|Laboratoire d'Excellence "Corail", 58, avenue Paul Alduy, 66860 Perpignan, France. banaigs@univ-perp.fr.
authors.forename: Bernard
authors.initials: B
authors.lastname: Banaigs
authors.affiliation: Centre de Recherche Insulaire et Observatoire de l'Environnement (CRIOBE), USR 3278 EPHE-CNRS-UPVD, Université de Perpignan Via Domitia, 58 avenue P. Alduy, 66860 Perpignan, France. nicolas.inguimbert@univ-perp.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Inguimbert
mesh_terms: D000595:Amino Acid Sequence; D000458:Cyanobacteria / Q000737:chemistry / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000096:biosynthesis* / Q000302:isolation & purification
chemical_list: C503384:Laxaphycin B; D010456:Peptides, Cyclic
keywords: Anabaena; Lyngbya; cyclic lipopeptide; non ribosomal peptides; solid phase peptide synthesis