title: Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species.
abstract: Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA. scohen@ucsd.edu ngianneschi@ucsd.edu.
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Daniel
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA. scohen@ucsd.edu ngianneschi@ucsd.edu.
authors.forename: Cassandra E
authors.initials: CE
authors.lastname: Callmann
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA. scohen@ucsd.edu ngianneschi@ucsd.edu.
authors.forename: Nathan C
authors.initials: NC
authors.lastname: Gianneschi
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA. scohen@ucsd.edu ngianneschi@ucsd.edu.
authors.forename: Seth M
authors.initials: SM
authors.lastname: Cohen
mesh_terms: D057927:Hydrophobic and Hydrophilic Interactions; D020782:Matrix Metalloproteinases / Q000737:chemistry* / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000737:chemistry*
chemical_list: D011108:Polymers; D017382:Reactive Oxygen Species; D020782:Matrix Metalloproteinases