title: First results about recovery of walking function in patients with intensive care unit-acquired muscle weakness from the General Weakness Syndrome Therapy (GymNAST) cohort study.
abstract: OBJECTIVE
  To describe the time course of recovery of walking function and other activities of daily living in patients with intensive care unit (ICU)-acquired muscle weakness.
  
  
  METHODS
  This is a cohort study.
  
  
  METHODS
  We included critically ill patients with ICU-acquired muscle weakness.
  
  
  METHODS
  Post-acute ICU and rehabilitation units in Germany.
  
  
  METHODS
  We measured walking function, muscle strength, activities in daily living, motor and cognitive function.
  
  
  RESULTS
  We recruited 150 patients (30% female) who fulfilled our inclusion and exclusion criteria. The primary outcome recovery of walking function was achieved after a median of 28.5 days (IQR=45) after rehabilitation onset and after a median of 81.5 days (IQR=64) after onset of illness. Our final multivariate model for recovery of walking function included two clinical variables from baseline: the Functional Status Score ICU (adjusted HR=1.07 (95% CI 1.03 to 1.12) and the ability to reach forward in cm (adjusted HR=1.02 (95% CI 1.00 to 1.04). All secondary outcomes but not pain improved significantly in the first 8 weeks after study onset.
  
  
  CONCLUSIONS
  We found good recovery of walking function for most patients and described the recovery of walking function of people with ICU-acquired muscle weakness.
  
  
  BACKGROUND
  Sächsische Landesärztekammer EK-BR-32/13-1; DRKS00007181, German Register of Clinical Trials.
authors.affiliation: Wissenschaftliches Institut, Private Europäische Medizinische Akademie der Klinik Bavaria in Kreischa, Kreischa, Germany Department of Public Health, Medizinische Fakultät 'Carl Gustav Carus', Technische Universität Dresden, Dresden, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Mehrholz
authors.affiliation: Wissenschaftliches Institut, Private Europäische Medizinische Akademie der Klinik Bavaria in Kreischa, Kreischa, Germany.
authors.forename: Simone
authors.initials: S
authors.lastname: Mückel
authors.affiliation: Fach und Privatkrankenhaus, Klinik Bavaria in Kreischa, Kreischa, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Oehmichen
authors.affiliation: Fach und Privatkrankenhaus, Klinik Bavaria in Kreischa, Kreischa, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Pohl
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003422:Critical Care; D005260:Female; D005858:Germany; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D015999:Multivariate Analysis; D018908:Muscle Weakness / Q000209:etiology / Q000534:rehabilitation*; D011446:Prospective Studies; D020127:Recovery of Function; D012307:Risk Factors; D013577:Syndrome; D013997:Time Factors; D016896:Treatment Outcome; D016138:Walking; D055815:Young Adult
keywords: REHABILITATION MEDICINE