title: Catechol-O-Methyltransferase Gene Polymorphisms in Specific Obsessive-Compulsive Disorder Patients' Subgroups.
abstract: Pharmacological data and animal models support the hypothesis that the dopaminergic (DA) system is implicated in obsessive-compulsive disorder (OCD). Therefore, this case-control study assessed whether genetics variations in catechol-O-methyltransferase gene (COMT) could influence susceptibility to OCD and OCD features in a Brazilian sample. A sample of 199 patients with OCD and 200 healthy individuals was genotyped for -287A > G (rs2075507) and Val158Met (rs4680) single nucleotide polymorphisms (SNPs) by TaqMan(®) or restriction mapping. We observed a statistically significant predominance of the Met low-activity allele in the male patient group as compared to the male healthy control group. The -287A > G polymorphism's genotypes and alleles were significantly overrepresented among male individuals with ordering and female subjects with washing symptoms. We also found female hoarders to exhibit a significant higher frequency of the low activity Met/Met genotype of Val158Met polymorphism compared to female patients who did not express this dimension. Our data suggest an influence of COMT polymorphisms on OCD and OCD patients' features, such as gender, and ordering, washing, and hoarding symptom dimensions. Further studies to confirm the clinical importance of COMT SNPs in OCD are warranted.
authors.affiliation: Departamento de Biologia Geral, Instituto de Biologia, Universidade Federal Fluminense (UFF), 24061-970, Niterói, RJ, Brazil.
authors.forename: Fernanda Brito
authors.initials: FB
authors.lastname: Melo-Felippe
authors.affiliation: Programa de Transtornos Obsessivo-Compulsivos e de Ansiedade, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.|Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, Brazil.
authors.forename: Juliana Braga
authors.initials: JB
authors.lastname: de Salles Andrade
authors.affiliation: Departamento de Biologia Geral, Instituto de Biologia, Universidade Federal Fluminense (UFF), 24061-970, Niterói, RJ, Brazil.
authors.forename: Isabele Gomes
authors.initials: IG
authors.lastname: Giori
authors.affiliation: Departamento de Biologia Geral, Instituto de Biologia, Universidade Federal Fluminense (UFF), 24061-970, Niterói, RJ, Brazil.
authors.forename: Tamiris
authors.initials: T
authors.lastname: Vieira-Fonseca
authors.affiliation: Programa de Transtornos Obsessivo-Compulsivos e de Ansiedade, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.|Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, Brazil.|School of Psychological Sciences, Monash University, Melbourne, Australia.
authors.forename: Leonardo Franklin
authors.initials: LF
authors.lastname: Fontenelle
authors.affiliation: Departamento de Biologia Geral, Instituto de Biologia, Universidade Federal Fluminense (UFF), 24061-970, Niterói, RJ, Brazil. fabianabk@yahoo.com.
authors.forename: Fabiana Barzotti
authors.initials: FB
authors.lastname: Kohlrausch
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors
chemical_list: C588010:COMT protein, human; D002394:Catechol O-Methyltransferase
keywords: Brazil; COMT; Dopamine; Genetics; Obsessive–compulsive disorder; SNP