title: Advanced Glycation End Products: Link between Diet and Ovulatory Dysfunction in PCOS?
abstract: PCOS is the most common cause of anovulation in reproductive-aged women with 70% experiencing ovulatory problems. Advanced glycation end products are highly reactive molecules that are formed by non-enzymatic reactions of sugars with proteins, nucleic acids and lipids. AGEs are also present in a variety of diet where substantial increase in AGEs can result due to thermal processing and modifications of food. Elevation in bodily AGEs, produced endogenously or absorbed exogenously from high-AGE diets, is further exaggerated in women with PCOS and is associated with ovulatory dysfunction. Additionally, increased expression of AGEs as pro-inflammatory receptors in the ovarian tissue has been observed in women with PCOS. In this review, we summarize the role of dietary AGEs as mediators of metabolic and reproductive alterations in PCOS. Once a mechanistic understanding of the relationship between AGEs and anovulation is established, there is a promise that such knowledge will contribute to the subsequent development of targeted pharmacological therapies that will treat anovulation and improve ovarian health in women with PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, NY 11219, USA. drgargdeepika@gmail.com.
authors.forename: Deepika
authors.initials: D
authors.lastname: Garg
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Biology, School of Medicine, New York University, 180 Varick St., Sixth Floor, New York, NY 11014, USA. zom00@hotmail.com.
authors.forename: Zaher
authors.initials: Z
authors.lastname: Merhi
mesh_terms: D004032:Diet; D005260:Female; D017127:Glycation End Products, Advanced / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood / Q000209:etiology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000209:etiology; D000067759:Receptor for Advanced Glycation End Products / Q000097:blood; D012098:Reproduction
chemical_list: C000593871:AGER protein, human; D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products
keywords: advanced glycation end products; anovulation; polycystic ovary syndrome (PCOS); receptor for advanced glycation endproducts (RAGE); soluble receptor for advanced glycation end products (sRAGE)