title: Three new aaptamine derivatives from the South China Sea sponge Aaptos aaptos.
abstract: Three new aaptamine derivatives (1-3), together with six known related compounds (4-9), have been isolated from the South China Sea sponge Aaptos aaptos. The structures of all compounds were unambiguously elucidated on the basis of spectroscopic analyses. Compounds 1, 4, 5, 7, and 9 showed cytotoxic activities against HeLa, K562, MCF-7, and U937 cell lines with IC50 values in the range of 0.90-12.32 μM.
authors.affiliation: a Key Laboratory for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine , Shanghai Jiao Tong University , Shanghai 200127 , China.|b College of Food Science and Technology , Shanghai Ocean University , Shanghai 201306 , China.
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Gan
authors.affiliation: b College of Food Science and Technology , Shanghai Ocean University , Shanghai 201306 , China.
authors.forename: Wen-Zhen
authors.initials: WZ
authors.lastname: Hu
authors.affiliation: a Key Laboratory for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine , Shanghai Jiao Tong University , Shanghai 200127 , China.|c Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences , Second Military Medical University , Shanghai 200433 , China.
authors.forename: Hao-Bing
authors.initials: HB
authors.lastname: Yu
authors.affiliation: a Key Laboratory for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine , Shanghai Jiao Tong University , Shanghai 200127 , China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: a Key Laboratory for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine , Shanghai Jiao Tong University , Shanghai 200127 , China.
authors.forename: Meng-Xue
authors.initials: MX
authors.lastname: Cao
authors.affiliation: b College of Food Science and Technology , Shanghai Ocean University , Shanghai 201306 , China.
authors.forename: Hua-Jin
authors.initials: HJ
authors.lastname: Shi
authors.affiliation: b College of Food Science and Technology , Shanghai Ocean University , Shanghai 201306 , China.
authors.forename: Yong-Feng
authors.initials: YF
authors.lastname: Kang
authors.affiliation: a Key Laboratory for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine , Shanghai Jiao Tong University , Shanghai 200127 , China.
authors.forename: Bing-Nan
authors.initials: BN
authors.lastname: Han
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D008386:Marine Biology; D015394:Molecular Structure; D009287:Naphthyridines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D020298:U937 Cells
chemical_list: D000970:Antineoplastic Agents; D009287:Naphthyridines; C043986:aaptamine
keywords: Aaptos aaptos; aaptamine derivatives; cytotoxicity