title: Neurobiology of rodent self-grooming and its value for translational neuroscience.
abstract: Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders--including models of autism spectrum disorder and obsessive compulsive disorder--that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action.
authors.affiliation: Research Institute of Marine Drugs and Nutrition, Key Laboratory of Aquatic Product Processing and Safety, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.|Neuroscience Research Laboratory, ZENEREI Research Center, Slidell, Louisiana 70458, USA.|Institute of Translational Biomedicine, St Petersburg State University, St Petersburg 199034, Russia.|Institutes of Chemical Technologies and Natural Sciences, Ural Federal University, Ekaterinburg 620002, Russia.
authors.forename: Allan V
authors.initials: AV
authors.lastname: Kalueff
authors.affiliation: Neuroscience Research Laboratory, ZENEREI Research Center, Slidell, Louisiana 70458, USA.
authors.forename: Adam Michael
authors.initials: AM
authors.lastname: Stewart
authors.affiliation: Research Institute of Marine Drugs and Nutrition, Key Laboratory of Aquatic Product Processing and Safety, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.|Department of Psychology and Neuroscience, Dalhousie University, 1355 Oxford St, Life Sciences Centre, Halifax, Nova Scotia B3H4R2, Canada.|Graduate Institute of Neural Cognitive Science, China Medical University, Taichung 000001, Taiwan.
authors.forename: Cai
authors.initials: C
authors.lastname: Song
authors.affiliation: Department of Psychology, University of Michigan, 525E University Str, Ann Arbor, Michigan 48109, USA.
authors.forename: Kent C
authors.initials: KC
authors.lastname: Berridge
authors.affiliation: McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, Massachusetts 02139, USA.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Graybiel
authors.affiliation: Department of Psychology and Neuroscience, Dalhousie University, 1355 Oxford St, Life Sciences Centre, Halifax, Nova Scotia B3H4R2, Canada.
authors.forename: John C
authors.initials: JC
authors.lastname: Fentress
mesh_terms: D000818:Animals; D000067877:Autism Spectrum Disorder / Q000503:physiopathology*; D001522:Behavior, Animal / Q000502:physiology*; D004195:Disease Models, Animal; D006120:Grooming / Q000502:physiology*; D006801:Humans; D009446:Neurobiology; D009771:Obsessive-Compulsive Disorder / Q000235:genetics / Q000503:physiopathology*