title: Results After Anterior Cruciate Ligament Reconstruction in Patients Older Than 40 Years: How Do They Compare With Younger Patients? A Systematic Review and Comparison With Younger Populations.
abstract: BACKGROUND
  Anterior cruciate ligament (ACL) reconstruction in older patients is a controversial topic among orthopaedic surgeons.
  
  
  OBJECTIVE
  To determine the outcomes, failure, and morbidity associated with ACL reconstruction in patients older than 40 years and to compare it with nonoperative treatment as well as results of ACL reconstruction in a younger patient population.
  
  
  METHODS
  A systematic review of the literature from 1970 to 2015 was conducted utilizing MEDLINE, CINAHL, and the Cochrane Central Register databases using PRISMA guidelines.
  
  
  METHODS
  Inclusion criteria were studies with longer than 2-year follow-up of primary ACL reconstruction and minimum age of patients older than 40 years, inclusive of any graft type or source and of any concomitant meniscal pathology.
  
  
  METHODS
  Systematic review.
  
  
  METHODS
  Level 4.
  
  
  METHODS
  Two independent reviewers collected demographic, preoperative, intraoperative, and postoperative data.
  
  
  RESULTS
  Twelve studies with a total of 452 patients were included. The mean patient age was 47.8 years (range, 40-66 years) with a mean follow-up of 53.3 months (minimum, 24 months). Lysholm scores improved from 53.9 to 90.5 in the 11 operative studies. The only nonoperative study reported a mean Lysholm score of 82 after rehabilitation. International Knee Documentation Committee (IKDC) scores of A or B were found in 81%. Tegner activity scores averaged 4.7 preinjury, fell to 2.9 preoperatively, and returned to 4.7 postoperatively. The reported failure rate was 2.3%. There were few complications, and failure rate was similar in younger patients.
  
  
  CONCLUSIONS
  The data confirm that ACL reconstruction can be recommended to patients older than 40 years who wish to maintain an active lifestyle or have symptomatic instability with daily activities. Patient-based outcomes scores were better in the operative studies compared with the single nonoperative study in this patient population.
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Mall
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Frank
authors.forename: Bryan M
authors.initials: BM
authors.lastname: Saltzman
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Cole
authors.forename: Bernard R
authors.initials: BR
authors.lastname: Bach
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000070598:Anterior Cruciate Ligament Injuries / Q000150:complications / Q000601:surgery* / Q000628:therapy; D059549:Anterior Cruciate Ligament Reconstruction; D001168:Arthritis / Q000209:etiology; D001265:Athletic Injuries / Q000150:complications / Q000601:surgery / Q000628:therapy; D006801:Humans; D065466:Lysholm Knee Score; D008875:Middle Aged; D013997:Time Factors; D017211:Treatment Failure; D016896:Treatment Outcome