title: The chemistry and biology of guanidine natural products.
abstract: The present review discusses the isolation, structure determination, synthesis, biosynthesis and biological activities of secondary metabolites bearing a guanidine group. Topics include non-ribosomal peptides, alkaloids, guanidine-bearing terpenes, polyketides and shikimic acid derivatives from natural sources. A critical analysis of some yet underdeveloped aspects of guanidine metabolites is also presented.
authors.affiliation: Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil. rgsberlinck@iqsc.usp.br.
authors.forename: Roberto G S
authors.initials: RG
authors.lastname: Berlinck
authors.forename: Stelamar
authors.initials: S
authors.lastname: Romminger
mesh_terms: D000818:Animals; D001419:Bacteria / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006146:Guanidines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007448:Invertebrates / Q000737:chemistry; D008386:Marine Biology; D015394:Molecular Structure
chemical_list: D001688:Biological Products; D006146:Guanidines