title: Asthma phenotypes and IgE responses.
abstract: The discovery of IgE represented a major breakthrough in allergy and asthma research, whereas the clinical interest given to IgE in asthma has been blurred until the arrival of anti-IgE biotherapy. Novel facets of the complex link between IgE and asthma have been highlighted by the effect of this treatment and by basic research. In parallel, asthma phenotyping recently evolved to the concept of endotypes, relying on identified/suspected pathobiological mechanisms to phenotype patients, but has not yet clearly positioned IgE among biomarkers of asthma.In this review, we first summarise recent knowledge about the regulation of IgE production and its main receptor, FcεRI. In addition to allergens acting as classical IgE inducers, viral infections as well as air pollution may trigger the IgE pathway, notably resetting the threshold of IgE sensitivity by regulating FcεRI expression. We then analyse the place of IgE in different asthma endo/phenotypes and discuss the potential interest of IgE among biomarkers in asthma.
authors.affiliation: Institut de Recherche Expérimentale et Clinique, Pôle de Pneumologie, Université catholique de Louvain, Brussels and Walloon Institute for Excellence in Lifesciences and Biotechnology (WELBIO), Belgium Dept of Chest Medicine, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium These authors contributed equally to this work.
authors.forename: Antoine
authors.initials: A
authors.lastname: Froidure
authors.affiliation: Institut de Recherche Expérimentale et Clinique, Pôle de Pneumologie, Université catholique de Louvain, Brussels and Walloon Institute for Excellence in Lifesciences and Biotechnology (WELBIO), Belgium Dept of Chest Medicine, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium These authors contributed equally to this work.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Mouthuy
authors.affiliation: Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, London, UK.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Durham
authors.affiliation: INSERM U 1067, CNRS UMR 7333 Aix Marseille Université and Dépt des Maladies Respiratoires, Assistance Publique des Hôpitaux de Marseille, Marseille, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Chanez
authors.affiliation: Institut de Recherche Expérimentale et Clinique, Pôle de Pneumologie, Université catholique de Louvain, Brussels and Walloon Institute for Excellence in Lifesciences and Biotechnology (WELBIO), Belgium Dept of Chest Medicine, Centre Hospitalier Universitaire de Mont-Godinne, Université catholique de Louvain, Yvoir, Belgium.
authors.forename: Yves
authors.initials: Y
authors.lastname: Sibille
authors.affiliation: Institut de Recherche Expérimentale et Clinique, Pôle de Pneumologie, Université catholique de Louvain, Brussels and Walloon Institute for Excellence in Lifesciences and Biotechnology (WELBIO), Belgium Dept of Chest Medicine, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium charles.pilette@uclouvain.be.
authors.forename: Charles
authors.initials: C
authors.lastname: Pilette
mesh_terms: D000393:Air Pollutants / Q000276:immunology; D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000276:immunology*; D015415:Biomarkers; D058068:Endophenotypes; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D010641:Phenotype; D017455:Receptors, IgE / Q000276:immunology*
chemical_list: D000393:Air Pollutants; D000485:Allergens; D015415:Biomarkers; D017455:Receptors, IgE; D007073:Immunoglobulin E