title: A Centromere-Signaling Network Underlies the Coordination among Mitotic Events.
abstract: There is increasing evidence that regulators of the spindle checkpoint, kinetochore-microtubule attachments, and sister chromatid cohesion are part of an interconnected mitotic regulatory circuit with two positive feedback loops and the chromosome passenger complex (CPC) at its center. If true, this conceptual breakthrough needs to be integrated into models of mitosis. In this review, we describe this circuit and point out how the double feedback loops could provide insights into the self-organization of some mitotic processes and the autonomy of every chromosome on the mitotic spindle. We also provide working models for how mitotic events may be coordinated by this circuit.
authors.affiliation: Department of Cell Biology, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA.
authors.forename: Prasad
authors.initials: P
authors.lastname: Trivedi
authors.affiliation: Department of Cell Biology, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA; Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA. Electronic address: pts7h@virginia.edu.
authors.forename: P Todd
authors.initials: PT
authors.lastname: Stukenberg
mesh_terms: D002503:Centromere / Q000378:metabolism*; D008938:Mitosis; D015398:Signal Transduction