title: Genetic low nephron number hypertension is associated with altered expression of key components of the renin-angiotensin system during nephrogenesis.
abstract: OBJECTIVE
  This study investigates key components of the renin-angiotensin system (RAS) which play a central role in nephrogenesis and possibly in fetal programming of arterial hypertension in adult life.
  
  
  METHODS
  We compared a genetic rat model with inborn nephron deficit, the Munich Wistar Fromter rat (MWF), to normotensive Wistar rats during nephrogenesis at day 19 of fetal development (E19) and at postnatal day 7 (D7).
  
  
  RESULTS
  At E19 renal mRNA of angiotensin II type 1a (AT1a) (-50%, P<0.05) and type 1b (AT1b) (-55%, P<0.05) receptors were significantly decreased and renal mRNA expression of angiotensin II type 2 (AT2) receptor was fivefold increased in MWF (n=8) as compared to Wistar rats (n=8). At D7 renal mRNA expression of AT1a (-42%, P<0.05) remained lower in MWF (n=8) as compared to Wistar (n=7). Renal mRNA expression of AT2 (-30%, P>0.05) decreased in MWF (n=8) to about the level of the Wistar control (n=6).
  
  
  CONCLUSIONS
  Altered fetal expression of key molecules of the renin-angiotensin system in MWF indicates a possible role in genetic low nephron number hypertension.
authors.forename: Anne Lena
authors.initials: AL
authors.lastname: Faensen
authors.forename: Markus Wehland
authors.initials: MW
authors.lastname: von Trebra
authors.forename: Florian
authors.initials: F
authors.lastname: Freese
authors.forename: Reinhold
authors.initials: R
authors.lastname: Kreutz
authors.forename: Christian
authors.initials: C
authors.lastname: Bamberg
authors.forename: Larry
authors.initials: L
authors.lastname: Hinkson
authors.forename: Lars
authors.initials: L
authors.lastname: Rothermund
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006973:Hypertension / Q000196:embryology* / Q000235:genetics / Q000378:metabolism; D009399:Nephrons / Q000196:embryology* / Q000378:metabolism; D038081:Organogenesis / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012084:Renin-Angiotensin System / Q000235:genetics* / Q000502:physiology
chemical_list: D015415:Biomarkers