title: Cell- and Gene- Based Therapeutics for Periodontal Regeneration.
abstract: Periodontitis is a disease of the periodontium, characterized by loss of connective tissue attachment and supporting the alveolar bone. Therefore, to regenerate these lost tissues of the periodontium researchers have included a variety of surgical procedures including grafting materials growth factors and the use of barrier membranes, ultimately resulting into regeneration that is biologically possible but clinically unpredictable. Recently a newer approach of delivering DNA plasmids as therapeutic agents is gaining special attention and is called gene delivery method. Gene therapy being considered a novel approach have a potential to channel their signals in a very systematic and controlled manner thereby providing encoded proteins at all stages of tissue regeneration. The aim of this review was to enlighten a view on the application involving gene delivery and tissue engineering in periodontal regeneration.
authors.affiliation: Department of Periodontology, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra, India.
authors.forename: Keshava
authors.initials: K
authors.lastname: Abbayya
authors.affiliation: Department of Periodontology, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra, India.
authors.forename: Sameer Anil
authors.initials: SA
authors.lastname: Zope
authors.affiliation: Department of Orthodontics, Maratha Mandal Dental College, Belgaum, Karnataka, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Naduwinmani
authors.affiliation: Department of Periodontology, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra, India.
authors.forename: Apurva
authors.initials: A
authors.lastname: Pisal
authors.affiliation: Department of Prosthodontics, A.C.P.M. Dental College, Dhule, Maharashtra, India.
authors.forename: Nagraj
authors.initials: N
authors.lastname: Puthanakar
keywords: Gene; growth factors; periodontal regeneration; stem cells; tissue engineering; vectors