title: Distribution of LIM domain kinase 1 in the olfactory bulb, cerebral cortex, hippocampus, and cerebellum of the App/PS+/- mice.
abstract: LIM domain kinase 1 (LIMK1), an actin-binding kinase, can phosphorylate and inactivate its substrates, and can regulate long-term memory and synaptic plasticity. Both β-amyloid precursor protein (App) and presenilin (PS) are functional degeneration factors during early neuronal development, and are considered as potential factors that contribute to the development of Alzheimer's disease (AD). However, hardly any information is available about the distribution and expression of LIMK1. Thus, using the App and PS deficient mice, the role of LIMK1 was demonstrated in the absence of App and PS. Our results showed that LIMK1 was present in the nerve fiber layer and external plexiform layer of the olfactory bulb, as well as in the mitral cells and Purkinje cells of the cerebellum in App and PS deficient mice. Additionally, LIMK1 was concentrated in the granule cell layer of the olfactory bulb and cerebellum and LIMK1 positive cells were located in the CA1 region of the hippocampus. Our study indicates that there is a connection between LIMK1 and AD in the mouse model of AD. This might explain neurological problems such as cerebellar ataxia, impaired long-term memory, and impaired synaptic plasticity observed in AD.
authors.affiliation: Institute of Neurobiology, College of Life Science, Henan University, Kaifeng, Henan, China.|Translational Medicine Center, Huaihe Hospital, Henan University, Kaifeng, Henan, China.
authors.forename: L
authors.initials: L
authors.lastname: An
authors.affiliation: Institute of Neurobiology, College of Life Science, Henan University, Kaifeng, Henan, China.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.affiliation: Institute of Neurobiology, College of Life Science, Henan University, Kaifeng, Henan, China.
authors.forename: W W
authors.initials: WW
authors.lastname: Li
authors.affiliation: Institute of Neurobiology, College of Life Science, Henan University, Kaifeng, Henan, China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Shi
authors.affiliation: Translational Medicine Center, Huaihe Hospital, Henan University, Kaifeng, Henan, China.
authors.forename: X H
authors.initials: XH
authors.lastname: Lin
authors.affiliation: Institute of Neurobiology, College of Life Science, Henan University, Kaifeng, Henan, China.
authors.forename: D M
authors.initials: DM
authors.lastname: Yu
authors.affiliation: Institute of Neurobiology, College of Life Science, Henan University, Kaifeng, Henan, China.
authors.forename: J B
authors.initials: JB
authors.lastname: Deng
authors.affiliation: Translational Medicine Center, Huaihe Hospital, Henan University, Kaifeng, Henan, China.
authors.forename: X Q
authors.initials: XQ
authors.lastname: Ren
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002531:Cerebellum / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D004195:Disease Models, Animal; D015870:Gene Expression; D006579:Heterozygote; D006624:Hippocampus / Q000378:metabolism*; D007150:Immunohistochemistry; D054461:Lim Kinases / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D009830:Olfactory Bulb / Q000378:metabolism*; D053763:Presenilins / Q000235:genetics / Q000378:metabolism
chemical_list: D016564:Amyloid beta-Protein Precursor; D053763:Presenilins; D054461:Lim Kinases; C515893:Limk1 protein, mouse