title: Mast Cell-Mediated Mechanisms of Nociception.
abstract: Mast cells are tissue-resident immune cells that release immuno-modulators, chemo-attractants, vasoactive compounds, neuropeptides and growth factors in response to allergens and pathogens constituting a first line of host defense. The neuroimmune interface of immune cells modulating synaptic responses has been of increasing interest, and mast cells have been proposed as key players in orchestrating inflammation-associated pain pathobiology due to their proximity to both vasculature and nerve fibers. Molecular underpinnings of mast cell-mediated pain can be disease-specific. Understanding such mechanisms is critical for developing disease-specific targeted therapeutics to improve analgesic outcomes. We review molecular mechanisms that may contribute to nociception in a disease-specific manner.
authors.affiliation: Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA. aaich@umn.edu.
authors.forename: Anupam
authors.initials: A
authors.lastname: Aich
authors.affiliation: Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA. afrinl@umn.edu.
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Afrin
authors.affiliation: Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA. gupta014@umn.edu.
authors.forename: Kalpna
authors.initials: K
authors.lastname: Gupta
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications / Q000276:immunology / Q000473:pathology; D000818:Animals; D016207:Cytokines / Q000276:immunology; D006801:Humans; D006930:Hyperalgesia / Q000150:complications / Q000276:immunology / Q000473:pathology; D007249:Inflammation / Q000150:complications / Q000276:immunology / Q000473:pathology; D008407:Mast Cells / Q000276:immunology / Q000473:pathology*; D008881:Migraine Disorders / Q000150:complications / Q000276:immunology / Q000473:pathology; D009369:Neoplasms / Q000150:complications / Q000276:immunology / Q000473:pathology; D059225:Nociception; D010146:Pain / Q000150:complications* / Q000276:immunology / Q000473:pathology*
chemical_list: D016207:Cytokines
keywords: cancer; cytokines; hyperalgesia; inflammation; mast cells; migraine; pain; sickle cell disease; substance P; tryptase