title: Pulsatility of Hypothalamo-Pituitary Hormones: A Challenge in Quantification.
abstract: Neuroendocrine systems control many of the most fundamental physiological processes, e.g., reproduction, growth, adaptations to stress, and metabolism. Each such system involves the hypothalamus, the pituitary, and a specific target gland or organ. In the quantification of the interactions among these components, biostatistical modeling has played an important role. In the present article, five key challenges to an understanding of the interactions of these systems are illustrated and discussed critically.
authors.affiliation: Department of Statistics, University of Virginia, Charlottesville, Virginia; and.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Keenan
authors.affiliation: Department of Medicine, Endocrine Research Unit, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota veldhuis.johannes@mayo.edu.
authors.forename: Johannes D
authors.initials: JD
authors.lastname: Veldhuis
mesh_terms: D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism* / Q000502:physiology*; D007031:Hypothalamus / Q000378:metabolism* / Q000502:physiology*; D010902:Pituitary Gland / Q000378:metabolism* / Q000502:physiology*; D010907:Pituitary Hormones / Q000378:metabolism*
chemical_list: D010907:Pituitary Hormones