title: Relationship of Genetic Polymorphisms of the Chemokine, CCL5, and Its Receptor, CCR5, with Coronary Artery Disease in Taiwan.
abstract: The chemokine receptor CCR5 polymorphism, which confers resistance to HIV infection, has been associated with reduced risk of cardiovascular disease. However, the association of the chemokine, CCL5, and its receptor, CCR5, polymorphism and coronary artery disease (CAD) in the Taiwanese has not been studied. In this study, 483 subjects who received elective coronary angiography were recruited from Chung Shan Medical University Hospital. CCL5-403 and CCR5-59029 were determined by polymerase chain reaction-restriction fragment length polymorphism. We found that CCL5-403 with TT genotype frequencies was significantly associated with the risk of CAD group (odds ratio = 3.063 and p = 0.012). Moreover, the frequencies of CCR5-59029 with GG or GA genotype were higher than AA genotype in acute coronary syndrome individuals (odds ratio = 1.853, CI = 1.176-2.921, p = 0.008). In conclusion, we found that CCL5-403 polymorphism may increase genetic susceptibility of CAD. CCL5-403 or CCR5-59029 single nucleotide polymorphism may include genotype score and it may predict cardiovascular event.
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan ; Division of Cardiology, Department of Internal Medicine, Yuan-Sheng Hospital and Changhua Christian Hospital, Yuanlin Branch, Yuanlin 510, Taiwan.
authors.forename: Ke-Hsin
authors.initials: KH
authors.lastname: Ting
authors.affiliation: Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan ; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
authors.forename: Kwo-Chang
authors.initials: KC
authors.lastname: Ueng
authors.affiliation: School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan ; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
authors.forename: Whei-Ling
authors.initials: WL
authors.lastname: Chiang
authors.affiliation: Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan ; Department of Forensic Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
authors.forename: Ying-Erh
authors.initials: YE
authors.lastname: Chou
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan ; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
authors.forename: Shun-Fa
authors.initials: SF
authors.lastname: Yang
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan ; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan ; Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
authors.forename: Po-Hui
authors.initials: PH
authors.lastname: Wang