title: Biodegradable polydioxanone stents in the treatment of adult patients with tracheal narrowing.
abstract: BACKGROUND
  Biodegradable stents that disintegrate after a period of time are expected to be well tolerated and have advantages over other stents that are more commonly used in practice today. Polydioxanone is a biodegradable polymer that is widely used during surgery with absorbable sutures.
  
  
  METHODS
  We present cases from the first four patients to undergo a tracheal polydioxanone stent insertion. Indications included significant non-malignant tracheal stenosis in cases where primary surgical treatment was not possible. The stents were implanted using rigid bronchoscopy and patients received regular follow-ups as needed. This use of biodegradable stents in adult patients was a novel, previously untested approach. The study was approved by the Institutional Ethics Committee and was based on a project entitled; "Biodegradable stents in the management of stenoses of large airways" (project NT 14146-3/2013).
  
  
  RESULTS
  Six biodegradable stents were implanted in four patients with benign stenoses. No technical difficulties occurred and no serious or life-threatening events were recorded. All patients reported some benefit from treatment.
  
  
  CONCLUSIONS
  Polydioxanone tracheal stents can be considered when a need for temporary support is expected, and as an alternative to other stents if the latter could compromise the patient. Owing to limited experience and observed disadvantages, further research is needed to fully assess this treatment.
  
  
  BACKGROUND
  This work is based on project NT14146 - Biodegradable stents in the management of stenoses of the large airways (2013-2015, MZ0/NT), registered from May 1, 2013 in The Research and Development and Innovation Information System of the Czech Republic and in ClinicalTrials.gov, reg. no. NCT02620319, December 2, 2015.
authors.affiliation: Department of Respiratory Medicine, Charles University 1st Faculty of Medicine and Thomayer Hospital, Videnska 800, Prague 4, 140 59, Czech Republic. ludek.stehlik@ftn.cz.
authors.forename: Ludek
authors.initials: L
authors.lastname: Stehlik
authors.affiliation: Department of Thoracic Surgery, Thomayer Hospital, Videnska 800, Prague 4, 140 59, Czech Republic. vladislav.hytych@ftn.cz.
authors.forename: Vladislav
authors.initials: V
authors.lastname: Hytych
authors.affiliation: ELLA-CS Ltd., Milady Horakove 504/45, Trebes, 500 06, Hradec Kralove, Czech Republic. jana.letackova@ellacs.eu.
authors.forename: Jana
authors.initials: J
authors.lastname: Letackova
authors.affiliation: ELLA-CS Ltd., Milady Horakove 504/45, Trebes, 500 06, Hradec Kralove, Czech Republic. petr.kubena@ellacs.eu.
authors.forename: Petr
authors.initials: P
authors.lastname: Kubena
authors.affiliation: Department of Respiratory Medicine, Charles University 1st Faculty of Medicine and Thomayer Hospital, Videnska 800, Prague 4, 140 59, Czech Republic. martina.vasakova@ftn.cz.
authors.forename: Martina
authors.initials: M
authors.lastname: Vasakova
mesh_terms: D000368:Aged; D001672:Biocompatible Materials / Q000737:chemistry*; D001999:Bronchoscopy; D018153:Czech Republic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016687:Polydioxanone / Q000737:chemistry*; D015607:Stents / Q000145:classification*; D014132:Trachea / Q000601:surgery*; D014135:Tracheal Stenosis / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D016687:Polydioxanone