title: Silver-Catalyzed Oxidative Cyclization of Propargylamide-Substituted Indoles: Synthesis of Phosphorated Indoloazepinones Derivatives.
abstract: A silver-catalyzed oxidative cyclization of 2- or 3-propargylamide-substituted indoles to synthesize phosphorated indoloazepinone derivatives is described. This reaction displays a difunctionalizalion of alkynes with diphenylphosphine oxides to construct a seven-membered ring through a radical cyclization process. The indoloazepinones derivatives are common structural motifs found in many natural products and pharmaceuticals.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Hua
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors.forename: Bo-Sheng
authors.initials: BS
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: He
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Qiu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors.forename: Xin-Xing
authors.initials: XX
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012834:Silver / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D001381:Azepines; D007211:Indoles; D012834:Silver