title: Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners.
abstract: Basigin, also called CD147 or EMMPRIN, is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. Basigin has isoforms; the common form (basigin or basigin-2) has two immunoglobulin domains, and the extended form (basigin-1) has three. Basigin is the receptor for cyclophilins, S100A9 and platelet glycoprotein VI, whereas basigin-1 serves as the receptor for the rod-derived cone viability factor. Basigin tightly associates with monocarboxylate transporters and is essential for their cell surface translocation and activities. In the same membrane plane, basigin also associates with other proteins including GLUT1, CD44 and CD98. The carbohydrate portion of basigin is recognized by lectins, such as galectin-3 and E-selectin. These molecular recognitions form the basis for the role of basigin in the transport of nutrients, migration of inflammatory leukocytes and induction of matrix metalloproteinases. Basigin is important in vision, spermatogenesis and other physiological phenomena, and plays significant roles in the pathogenesis of numerous diseases, including cancer. Basigin is also the receptor for an invasive protein RH5, which is present in malaria parasites.
authors.affiliation: Professor Emeritus, Nagoya University, 1204 Hirabariminami 2, Tenpaku, Nagoya 468-0020, Japan tmurama@med.nagoya-u.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Muramatsu
mesh_terms: D000818:Animals; D051926:Basigin / Q000378:metabolism*; D001798:Blood Proteins; D040502:Calgranulin B / Q000378:metabolism; D021983:Cyclophilins / Q000378:metabolism; D019040:E-Selectin / Q000378:metabolism; D005260:Female; D027261:Fusion Regulatory Protein-1 / Q000378:metabolism; D037502:Galectin 3 / Q000378:metabolism; D037161:Galectins; D051272:Glucose Transporter Type 1 / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D008288:Malaria / Q000378:metabolism*; D008297:Male; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism; D020033:Protein Isoforms / Q000378:metabolism; D013091:Spermatogenesis; D013879:Thioredoxins / Q000378:metabolism; D014785:Vision, Ocular
chemical_list: C497886:BSG protein, human; D001798:Blood Proteins; C497483:CD44 protein, human; D040502:Calgranulin B; D019040:E-Selectin; D027261:Fusion Regulatory Protein-1; D037502:Galectin 3; D037161:Galectins; D051272:Glucose Transporter Type 1; D018960:Hyaluronan Receptors; C428445:LGALS3 protein, human; C488098:NXNL1 protein, human; D009363:Neoplasm Proteins; D010980:Platelet Membrane Glycoproteins; D020033:Protein Isoforms; C495677:SLC2A1 protein, human; C098341:platelet membrane glycoprotein VI; D051926:Basigin; D013879:Thioredoxins; D021983:Cyclophilins
keywords: basigin; cyclophilins; glycoproteins; immunoglobulin superfamily; monocarboxylate transporters