title: Comparison of Genetic Variants in Cancer-Related Genes between Chinese Hui and Han Populations.
abstract: BACKGROUND
  The Chinese Hui population, as the second largest minority ethnic group in China, may have a different genetic background from Han people because of its unique demographic history. In this study, we aimed to identify genetic differences between Han and Hui Chinese from the Ningxia region of China by comparing eighteen single nucleotide polymorphisms in cancer-related genes.
  
  
  METHODS
  DNA samples were collected from 99 Hui and 145 Han people from the Ningxia Hui Autonomous Region in China, and SNPs were detected using an improved multiplex ligase detection reaction method. Genotyping data from six 1000 Genomes Project population samples (99 Utah residents with northern and western European ancestry (CEU), 107 Toscani in Italy (TSI), 108 Yoruba in Ibadan (YRI), 61 of African ancestry in the southwestern US (ASW), 103 Han Chinese in Beijing (CHB), and 104 Japanese in Tokyo (JPT)) were also included in this study. Differences in the distribution of alleles among the populations were assessed using χ2 tests, and FST was used to measure the degree of population differentiation.
  
  
  RESULTS
  We found that the genetic diversity of many SNPs in cancer-related genes in the Hui Chinese in Ningxia was different from that in the Han Chinese in Ningxia. For example, the allele frequencies of four SNPs (rs13361707, rs2274223, rs465498, and rs753955) showed different genetic distributions (p<0.05) between Chinese Ningxia Han and Chinese Ningxia Hui. Five SNPs (rs730506, rs13361707, rs2274223, rs465498 and rs753955) had different FST values (FST>0.000) between the Hui and Han populations.
  
  
  CONCLUSIONS
  These results suggest that some SNPs associated with cancer-related genes vary among different Chinese ethnic groups. We suggest that population differences should be carefully considered in evaluating cancer risk and prognosis as well as the efficacy of cancer therapy.
authors.affiliation: Cancer Research Institute of the General Hospital, Ningxia Medical University, Yinchuan, Ningxia, China.|Key Laboratory of Ningxia Reproduction and Heredity, Ningxia Medical University, Yinchuan, Ningxia, China.
authors.forename: Chaoyong
authors.initials: C
authors.lastname: Tian
authors.affiliation: Radiology Department of General Hospital, Ningxia Medical University, Yinchuan, Ningxia, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Xixian
authors.initials: X
authors.lastname: Ma
authors.affiliation: Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Epidemiology, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Cancer Research Institute of the General Hospital, Ningxia Medical University, Yinchuan, Ningxia, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Department of Epidemiology, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Yang
authors.affiliation: Cancer Research Institute of the General Hospital, Ningxia Medical University, Yinchuan, Ningxia, China.|Key Laboratory of Ningxia Reproduction and Heredity, Ningxia Medical University, Yinchuan, Ningxia, China.|Department of Epidemiology, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Yang
mesh_terms: D000328:Adult; D044466:Asian People / Q000208:ethnology* / Q000235:genetics; D002681:China / Q000208:ethnology; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult