title: Development of interventions for the secondary prevention of Alzheimer's dementia: the European Prevention of Alzheimer's Dementia (EPAD) project.
abstract: Alzheimer's dementia affects more than 40 million people worldwide with substantial increases in prevalence anticipated. Interventions that either modify risk or reduce the development of early disease could delay the onset of dementia or reduce the rate of cognitive and functional decline. The European Prevention of Alzheimer's Dementia (EPAD) is a public-private consortium, funded by the Innovative Medicines Initiative, designed to increase the likelihood of successful development of new treatments for the secondary prevention of Alzheimer's dementia. EPAD will help with testing of different agents in this pre-dementia population through four components: improvement of access to existing cohorts and registries, development of the EPAD Registry of approximately 24,000 people who might be at increased risk of developing Alzheimer's dementia, establishment of the EPAD Longitudinal Cohort Study of 6000 people at any one time, and establishment of an adaptive, proof-of-concept trial including 1500 participants at any given time. The need for EPAD and its key design elements are described, and we discuss EPAD in relation to similar projects in progress. These parallel efforts reflect the need for a coordinated, worldwide battle against dementia, in which EPAD will play a crucial role.
authors.affiliation: Centre for Clinical Brain Sciences, Department of Psychiatry, University of Edinburgh, Edinburgh, UK. Electronic address: craig.ritchie@ed.ac.uk.
authors.forename: Craig W
authors.initials: CW
authors.lastname: Ritchie
authors.affiliation: BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Molinuevo
authors.affiliation: Janssen Research & Development LLC, Titusville, NJ, USA.
authors.forename: Luc
authors.initials: L
authors.lastname: Truyen
authors.affiliation: Eisai, Woodcliff Lake, NJ, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Satlin
authors.affiliation: Janssen Research & Development, a Division of Janssen Pharmaceutica NV, Beerse, Belgium.
authors.forename: Serge
authors.initials: S
authors.lastname: Van der Geyten
authors.affiliation: Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Lovestone
mesh_terms: D000544:Alzheimer Disease / Q000517:prevention & control*; D003704:Dementia / Q000517:prevention & control*; D005060:Europe; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D055502:Secondary Prevention