title: Mussel-Inspired Anchoring of Polymer Loops That Provide Superior Surface Lubrication and Antifouling Properties.
abstract: We describe robustly anchored triblock copolymers that adopt loop conformations on surfaces and endow them with unprecedented lubricating and antifouling properties. The triblocks have two end blocks with catechol-anchoring groups and a looping poly(ethylene oxide) (PEO) midblock. The loops mediate strong steric repulsion between two mica surfaces. When sheared at constant speeds of ∼2.5 μm/s, the surfaces exhibit an extremely low friction coefficient of ∼0.002-0.004 without any signs of damage up to pressures of ∼2-3 MPa that are close to most biological bearing systems. Moreover, the polymer loops enhance inhibition of cell adhesion and proliferation compared to polymers in the random coil or brush conformations. These results demonstrate that strongly anchored polymer loops are effective for high lubrication and low cell adhesion and represent a promising candidate for the development of specialized high-performance biomedical coatings.
authors.affiliation: Chemical Research Institute, Samsung SDI Inc. , Gocheon-Dong, Uiwang-Si, Gyeonggi-Do 437-711, Republic of Korea.
authors.forename: Taegon
authors.initials: T
authors.lastname: Kang
authors.forename: Xavier
authors.initials: X
authors.lastname: Banquy
authors.forename: Jinhwa
authors.initials: J
authors.lastname: Heo
authors.forename: Chanoong
authors.initials: C
authors.lastname: Lim
authors.forename: Nathaniel A
authors.initials: NA
authors.lastname: Lynd
authors.forename: Pontus
authors.initials: P
authors.lastname: Lundberg
authors.forename: Dongyeop X
authors.initials: DX
authors.lastname: Oh
authors.forename: Han-Koo
authors.initials: HK
authors.lastname: Lee
authors.affiliation: Department of Biotechnology, Pukyong National University , Busan 608-737, Republic of Korea.
authors.forename: Yong-Ki
authors.initials: YK
authors.lastname: Hong
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Hwang
authors.forename: John Herbert
authors.initials: JH
authors.lastname: Waite
authors.forename: Jacob N
authors.initials: JN
authors.lastname: Israelachvili
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Hawker
mesh_terms: D000327:Adsorption; D000538:Aluminum Silicates / Q000737:chemistry; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D049872:Bivalvia / Q000737:chemistry; D002396:Catechols / Q000737:chemistry*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D017276:Friction; D054327:Lubricants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D008968:Molecular Conformation; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D011092:Polyethylene Glycols / Q000737:chemistry*; D000461:Rhodophyta / Q000187:drug effects / Q000254:growth & development; D013499:Surface Properties
chemical_list: D000538:Aluminum Silicates; D000890:Anti-Infective Agents; D002396:Catechols; D054327:Lubricants; D011092:Polyethylene Glycols; C011934:mica
keywords: antifouling; catechol; lubrication; polymer loops; surface forces apparatus