title: Monkey Feeding Assay for Testing Emetic Activity of Staphylococcal Enterotoxin.
abstract: Staphylococcal enterotoxins (SEs) are unique bacterial toxins that cause gastrointestinal toxicity as well as superantigenic activity. Since systemic administration of SEs induces superantigenic activity leading to toxic shock syndrome that may mimic enterotoxic activity of SEs such as vomiting and diarrhea, oral administration of SEs in the monkey feeding assay is considered as a standard method to evaluate emetic activity of SEs. This chapter summarizes and discusses practical considerations of the monkey feeding assay used in studies characterizing classical and newly identified SEs.
authors.affiliation: Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, 240 Wise Center Dr, 6100, Mississippi State, MS, 39762-6100, USA. seo@cvm.msstate.edu.
authors.forename: Keun Seok
authors.initials: KS
authors.lastname: Seo
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004768:Enterotoxins / Q000009:adverse effects / Q000276:immunology*; D005247:Feeding Behavior; D000882:Haplorhini; D013211:Staphylococcus aureus / Q000276:immunology*; D018089:Superantigens / Q000009:adverse effects / Q000276:immunology*; D014839:Vomiting / Q000175:diagnosis* / Q000209:etiology*
chemical_list: D004768:Enterotoxins; D018089:Superantigens
keywords: Emesis; Monkey feeding assay; Staphylococcal enterotoxin