title: CDH1/E-cadherin and solid tumors. An updated gene-disease association analysis using bioinformatics tools.
abstract: Cancer is a group of diseases that causes millions of deaths worldwide. Among cancers, Solid Tumors (ST) stand-out due to their high incidence and mortality rates. Disruption of cell-cell adhesion is highly relevant during tumor progression. Epithelial-cadherin (protein: E-cadherin, gene: CDH1) is a key molecule in cell-cell adhesion and an abnormal expression or/and function(s) contributes to tumor progression and is altered in ST. A systematic study was carried out to gather and summarize current knowledge on CDH1/E-cadherin and ST using bioinformatics resources. The DisGeNET database was exploited to survey CDH1-associated diseases. Reported mutations in specific ST were obtained by interrogating COSMIC and IntOGen tools. CDH1 Single Nucleotide Polymorphisms (SNP) were retrieved from the dbSNP database. DisGeNET analysis identified 609 genes annotated to ST, among which CDH1 was listed. Using CDH1 as query term, 26 disease concepts were found, 21 of which were neoplasms-related terms. Using DisGeNET ALL Databases, 172 disease concepts were identified. Of those, 80 ST disease-related terms were subjected to manual curation and 75/80 (93.75%) associations were validated. On selected ST, 489 CDH1 somatic mutations were listed in COSMIC and IntOGen databases. Breast neoplasms had the highest CDH1-mutation rate. CDH1 was positioned among the 20 genes with highest mutation frequency and was confirmed as driver gene in breast cancer. Over 14,000 SNP for CDH1 were found in the dbSNP database. This report used DisGeNET to gather/compile current knowledge on gene-disease association for CDH1/E-cadherin and ST; data curation expanded the number of terms that relate them. An updated list of CDH1 somatic mutations was obtained with COSMIC and IntOGen databases and of SNP from dbSNP. This information can be used to further understand the role of CDH1/E-cadherin in health and disease.
authors.affiliation: Laboratory of Cell-Cell Interaction in Cancer and Reproduction, Instituto de Biología & Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Fundación IBYME (FIBYME), Vuelta de Obligado 2490, Zip Code C1428ADN, Buenos Aires, Argentina. Electronic address: abascalflorencia@gmail.com.
authors.forename: María Florencia
authors.initials: MF
authors.lastname: Abascal
authors.affiliation: Laboratory of Cell-Cell Interaction in Cancer and Reproduction, Instituto de Biología & Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Fundación IBYME (FIBYME), Vuelta de Obligado 2490, Zip Code C1428ADN, Buenos Aires, Argentina. Electronic address: majobesso_88@hotmail.com.
authors.forename: María José
authors.initials: MJ
authors.lastname: Besso
authors.affiliation: Laboratory of Cell-Cell Interaction in Cancer and Reproduction, Instituto de Biología & Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Fundación IBYME (FIBYME), Vuelta de Obligado 2490, Zip Code C1428ADN, Buenos Aires, Argentina. Electronic address: rossomarina84@gmail.com.
authors.forename: Marina
authors.initials: M
authors.lastname: Rosso
authors.affiliation: Laboratory of Cell-Cell Interaction in Cancer and Reproduction, Instituto de Biología & Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Fundación IBYME (FIBYME), Vuelta de Obligado 2490, Zip Code C1428ADN, Buenos Aires, Argentina. Electronic address: viki_mvm89@hotmail.com.
authors.forename: María Victoria
authors.initials: MV
authors.lastname: Mencucci
authors.affiliation: Laboratory of Cell-Cell Interaction in Cancer and Reproduction, Instituto de Biología & Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Fundación IBYME (FIBYME), Vuelta de Obligado 2490, Zip Code C1428ADN, Buenos Aires, Argentina. Electronic address: aparicio.evangelina32@gmail.com.
authors.forename: Evangelina
authors.initials: E
authors.lastname: Aparicio
authors.affiliation: Laboratory of Cell-Cell Interaction in Cancer and Reproduction, Instituto de Biología & Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Fundación IBYME (FIBYME), Vuelta de Obligado 2490, Zip Code C1428ADN, Buenos Aires, Argentina. Electronic address: galaszapiro@gmail.com.
authors.forename: Gala
authors.initials: G
authors.lastname: Szapiro
authors.affiliation: Research Programme on Biomedical Informatics (GRIB) (IMIM), DCEXS, Universitat Pompeu Fabra, C/Dr Aiguader 88, Zip Code 08003, Barcelona, Spain. Electronic address: lfurlong@imim.es.
authors.forename: Laura Inés
authors.initials: LI
authors.lastname: Furlong
authors.affiliation: Laboratory of Cell-Cell Interaction in Cancer and Reproduction, Instituto de Biología & Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Fundación IBYME (FIBYME), Vuelta de Obligado 2490, Zip Code C1428ADN, Buenos Aires, Argentina; Laboratory of Cell-Cell Interaction in Cancer and Reproduction, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Fundación IBYME (FIBYME), Vuelta de Obligado 2490, Zip Code C1428ADN, Buenos Aires, Argentina. Electronic address: mhvazl@gmail.com.
authors.forename: Mónica Hebe
authors.initials: MH
authors.lastname: Vazquez-Levin
mesh_terms: D015703:Antigens, CD; D015820:Cadherins / Q000235:genetics*; D019295:Computational Biology; D057225:Data Mining; D030541:Databases, Genetic; D056726:Genetic Association Studies / Q000379:methods*; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins
keywords: Bioinformatics; CDH1; Epithelial Cadherin; Solid tumors; Somatic mutations