title: A probable drug-to-drug interaction between voriconazole and haloperidol in a CYP2C19 poor metabolizing patient. [corrected].
abstract: We present a case of Aspergillus fumigatus renal abscess treated with voriconazole. Following haloperidol treatment we observed an unexpected increase in voriconazole--trough concentrations and liver function tests. CYP2C19*2 loss of function allele was stated and the introduction of haloperidol, a weak CYP3A4 inhibitor, probably explains this interaction. [corrected]. Therapeutic drug monitoring and CYP2C19 genotyping may be suggested when administering voriconazole to complex patients.
authors.affiliation: Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Motta
authors.affiliation: Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Calcagno
authors.affiliation: Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino, Italy.
authors.forename: Lorena
authors.initials: L
authors.lastname: Baietto
authors.affiliation: Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: D'Avolio
authors.affiliation: Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino, Italy.
authors.forename: Francesco Giuseppe
authors.initials: FG
authors.lastname: De Rosa
authors.affiliation: Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Bonora
mesh_terms: D000038:Abscess / Q000382:microbiology*; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000378:metabolism*; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000378:metabolism; D001228:Aspergillosis / Q000150:complications*; D065731:Cytochrome P-450 CYP2C19 / Q000378:metabolism*; D004347:Drug Interactions; D016903:Drug Monitoring; D015658:HIV Infections / Q000150:complications*; D006220:Haloperidol / Q000008:administration & dosage / Q000378:metabolism; D006801:Humans; D016867:Immunocompromised Host; D007674:Kidney Diseases / Q000188:drug therapy*; D008297:Male; D065819:Voriconazole / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D014150:Antipsychotic Agents; D065731:Cytochrome P-450 CYP2C19; D006220:Haloperidol; D065819:Voriconazole