title: Quantitative analysis of ultrasonographic images and cytology in relation to histopathology of canine and feline liver: An ex-vivo study.
abstract: The aims of the present study were to investigate, in a standardized experimental condition, the usefulness of histogram analysis on ex-vivo ultrasonographic images of the liver of dogs and cats compared with histological alterations and to evaluate whether the combination of histogram parameters and cytology might improve diagnostic accuracy referring to optical microscopy as gold standard. Histogram-based parameters were calculated on ultrasonographic images of liver tissue samples collected from the cadavers of 68 dogs and 31 cats. Standard deviation of the histogram (SDH) had a higher sensitivity and specificity in the detection of the lesions in cat compared with dog. Matched results of cytology and SDH improved sensitivity and specificity in dog where as no substantial improvement was evident in cat. Quantitative analysis of ultrasonographic images of the liver in dog and cat could become a potentially useful tool in the distinction between normal and pathological organs.
authors.affiliation: Department of Animal Medicine, Production and Health, University of Padua, Viale dell'Università 16, Legnaro, PD 35020, Italy. Electronic address: tommaso.banzato@unipd.it.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Banzato
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padua, Viale dell'Università 16, Legnaro, PD 35020, Italy. Electronic address: mariaelena.gelain@unipd.it.
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Gelain
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padua, Viale dell'Università 16, Legnaro, PD 35020, Italy. Electronic address: luca.aresu@unipd.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Aresu
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padua, Viale dell'Università 16, Legnaro, PD 35020, Italy. Electronic address: cinzia.centelleghe@gmail.com.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Centelleghe
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padua, Viale dell'Università 16, Legnaro, PD 35020, Italy. Electronic address: silvialucia.benali@studenti.unipd.it.
authors.forename: Silvia Lucia
authors.initials: SL
authors.lastname: Benali
authors.affiliation: Department of Animal Medicine, Production and Health, University of Padua, Viale dell'Università 16, Legnaro, PD 35020, Italy. Electronic address: alessandro.zotti@unipd.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Zotti
mesh_terms: D000818:Animals; D002102:Cadaver; D002371:Cat Diseases / Q000000981:diagnostic imaging* / Q000473:pathology*; D002415:Cats; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000473:pathology*; D004285:Dogs; D005260:Female; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D008297:Male; D010865:Pilot Projects; D014463:Ultrasonography
keywords: Cytology; Histogram analysis; Histopathology; Liver; Ultrasound