title: Ocular dysmotility after intra-arterial chemotherapy for retinoblastoma.
abstract: We report the case of a 15-month-old boy with retinoblastoma who developed exotropia secondary to a right medial rectus infarct after intra-arterial chemotherapy. He had unilateral sporadic group C tumor (International Classification of Retinoblastoma) and was treated with intra-arterial melphalan. One week after the first session of intra-ophthalmic arterial melphalan chemotherapy, he was noted to have orbital congestion, exotropia, and right adduction limitation. Magnetic resonance imaging was suggestive of a right medial rectus infarct. The tumor showed a good response to intra-arterial chemotherapy but the exotropia persisted.
authors.affiliation: Department of Radiology, University of Utah, Salt Lake City, Utah.
authors.forename: Nathan G
authors.initials: NG
authors.lastname: Lambert
authors.affiliation: Department of Radiology, University of Utah, Salt Lake City, Utah.
authors.forename: Blair A
authors.initials: BA
authors.lastname: Winegar
authors.affiliation: Department of Radiology, University of Utah, Salt Lake City, Utah.
authors.forename: G Peter
authors.initials: GP
authors.lastname: Feola
authors.affiliation: Department of Ophthalmology, University of Louisville, Louisivlle, KY. Electronic address: aparna.ramasubramanian@louisville.edu.
authors.forename: Aparna
authors.initials: A
authors.lastname: Ramasubramanian
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000009:adverse effects*; D004487:Edema / Q000209:etiology; D005099:Exotropia / Q000139:chemically induced*; D005451:Fluorescein Angiography; D006801:Humans; D007223:Infant; D007238:Infarction / Q000139:chemically induced / Q000000981:diagnostic imaging; D007261:Infusions, Intra-Arterial; D007511:Ischemia / Q000139:chemically induced / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D008297:Male; D008558:Melphalan / Q000008:administration & dosage / Q000009:adverse effects*; D009135:Muscular Diseases / Q000209:etiology; D009801:Oculomotor Muscles / Q000098:blood supply; D009880:Ophthalmic Artery / Q000000981:diagnostic imaging / Q000187:drug effects; D010211:Papilledema / Q000209:etiology; D011859:Radiography; D019572:Retinal Neoplasms / Q000188:drug therapy*; D012175:Retinoblastoma / Q000188:drug therapy*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan