title: Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma.
abstract: The neutrophil/lymphocyte ratio (NLR) has been found to be predictive of survival outcome in a range of tumors. The purpose of this study was to investigate the prognostic value of pretreatment (NLR) in patients with laryngeal squamous cell carcinoma (SCC).
  
  
  
  A retrospective analysis of 140 patients with laryngeal SCC treated between 2005 and 2010 in the Hull and East Yorkshire Hospitals NHS Trust was carried out. Patient records were evaluated and both pretreatment neutrophil and lymphocyte counts were documented together with survival data, sex, smoking status, nodal classification, and disease staging.
  
  
  
  An elevated NLR was significantly associated with advanced disease stage (eg, node-positive and tumors stage III and IV). In addition, a high NLR was significantly associated with poor overall survival (OS) but not disease-free survival (DFS) on multivariate analysis, with the greatest significance seen in patients with the highest NLR.
  
  
  
  Pretreatment NLR may serve as a useful prognostic marker in laryngeal SCC; however, a large prospective study is required to determine an optimal NLR cutoff value. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1903-E1908, 2016.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Hull and East Yorkshire Hospitals NHS Trust, West Yorkshire, United Kingdom.
authors.forename: B Y Winson
authors.initials: BY
authors.lastname: Wong
authors.affiliation: Hull York Medical School, University of Hull, West Yorkshire, United Kingdom.
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Stafford
authors.affiliation: School of Biological, Biomedical and Environmental Sciences, University of Hull, West Yorkshire, United Kingdom.
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Green
authors.affiliation: School of Biological, Biomedical and Environmental Sciences, University of Hull, West Yorkshire, United Kingdom.
authors.forename: John
authors.initials: J
authors.lastname: Greenman
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis*; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology*; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D015996:Survival Rate
keywords: laryngeal cancer; lymphocytes; neutrophils; prognosis; survival