title: Non-AIDS-related malignancies: expert consensus review and practical applications from the multidisciplinary CANCERVIH Working Group.
abstract: Malignancies represent a major cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients. The introduction of combined antiretroviral therapy has modified the spectrum of malignancies in HIV infection with a decreased incidence of acquired immunodeficiency syndrome (AIDS) malignancies such as Kaposi's sarcoma and non-Hodgkin's lymphoma due to partial immune recovery and an increase in non-AIDS-defining malignancies due to prolonged survival. Management of HIV-infected patients with cancer requires a multidisciplinary approach, involving both oncologists and HIV physicians to optimally manage both diseases and drug interactions between anticancer and anti-HIV drugs. The French CANCERVIH group presents here a review and an experience of managing non-AIDS malignancies in HIV-infected individuals.
authors.affiliation: Department of Medical Oncology, Groupe hospitalier Pitié-Salpêtrière-Charles Foix, AP-HP, Paris INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé publique, Paris Pierre Louis Institute of Epidemiology and Public Health, Sorbonne Universités, UPMC Université Paris 06, Paris jean-philippe.spano@psl.aphp.fr.
authors.forename: J-P
authors.initials: JP
authors.lastname: Spano
authors.affiliation: Clinical Immunohaematology Service, Université Aix-Marseille, AP-HM Sainte-Marguerite, Marseille INSERM, U912 (SESSTIM), Marseille.
authors.forename: I
authors.initials: I
authors.lastname: Poizot-Martin
authors.affiliation: INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé publique, Paris Pierre Louis Institute of Epidemiology and Public Health, Sorbonne Universités, UPMC Université Paris 06, Paris.
authors.forename: D
authors.initials: D
authors.lastname: Costagliola
authors.affiliation: Department of Internal Medicine and Immunology, Hôpital Antoine Béclère, Clamart Faculty of Medicine, Université Paris-Sud, Le Kremlin-Bicêtre.
authors.forename: F
authors.initials: F
authors.lastname: Boué
authors.affiliation: Faculty of Medicine, Sorbonne Universités, UMPC Université Paris 06, Paris Hepatology Service, Hôpital Saint-Antoine, Paris.
authors.forename: O
authors.initials: O
authors.lastname: Rosmorduc
authors.affiliation: Pneumology Service, Hôpital Tenon, Paris.
authors.forename: A
authors.initials: A
authors.lastname: Lavolé
authors.affiliation: INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé publique, Paris Pierre Louis Institute of Epidemiology and Public Health, Sorbonne Universités, UPMC Université Paris 06, Paris Department of Hematology, Groupe hospitalier Pitié-Salpêtrière-Charles Foix, Paris.
authors.forename: S
authors.initials: S
authors.lastname: Choquet
authors.affiliation: Medical Oncology Service, Centre Léon Bérard, Lyon.
authors.forename: P-E
authors.initials: PE
authors.lastname: Heudel
authors.affiliation: Faculty of Medicine, Sorbonne Universités, UMPC Université Paris 06, Paris Department of Hematology, Groupe hospitalier Pitié-Salpêtrière-Charles Foix, Paris Centre for Research in Immunology and Infectious Diseases, Sorbonne Universités, UPMC Université Paris 06, Paris.
authors.forename: V
authors.initials: V
authors.lastname: Leblond
authors.affiliation: Department of Hematology, Groupe hospitalier Pitié-Salpêtrière-Charles Foix, Paris.
authors.forename: J
authors.initials: J
authors.lastname: Gabarre
authors.affiliation: INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé publique, Paris Pierre Louis Institute of Epidemiology and Public Health, Sorbonne Universités, UPMC Université Paris 06, Paris Department of Infectious Diseases, Groupe hospitalier Pitié-Salpêtrière-Charles Foix, Paris.
authors.forename: M-A
authors.initials: MA
authors.lastname: Valantin
authors.affiliation: Laboratory of Pharmacokinetics and Toxicology, Hôpital de La Timone, Marseille.
authors.forename: C
authors.initials: C
authors.lastname: Solas
authors.affiliation: Faculty of Medicine, Sorbonne Universités, UMPC Université Paris 06, Paris Department of Immunology, Groupe hospitalier Pitié-Salpêtrière-Charles Foix, Paris.
authors.forename: A
authors.initials: A
authors.lastname: Guihot
authors.affiliation: Faculty of Medicine, Sorbonne Universités, UMPC Université Paris 06, Paris Centre for Research in Immunology and Infectious Diseases, Sorbonne Universités, UPMC Université Paris 06, Paris.
authors.forename: G
authors.initials: G
authors.lastname: Carcelain
authors.affiliation: Faculty of Medicine, Sorbonne Universités, UMPC Université Paris 06, Paris Centre for Research in Immunology and Infectious Diseases, Sorbonne Universités, UPMC Université Paris 06, Paris.
authors.forename: B
authors.initials: B
authors.lastname: Autran
authors.affiliation: INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé publique, Paris Pierre Louis Institute of Epidemiology and Public Health, Sorbonne Universités, UPMC Université Paris 06, Paris Department of Infectious Diseases, Groupe hospitalier Pitié-Salpêtrière-Charles Foix, Paris.
authors.forename: C
authors.initials: C
authors.lastname: Katlama
authors.affiliation: Department of Oncology and Radiotherapy, Hôpital Saint Louis, Paris INSERM UMR_S 965, Université Paris Denis Diderot, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Quéro
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D023241:Antiretroviral Therapy, Highly Active; D032921:Consensus; D006689:Hodgkin Disease / Q000453:epidemiology* / Q000628:therapy; D006801:Humans; D011379:Prognosis; D012306:Risk; D012514:Sarcoma, Kaposi / Q000453:epidemiology* / Q000628:therapy
keywords: AIDS; HIV; cancer; review; treatment