title: Serous and mucinous borderline ovarian tumours: differences in clinical presentation, high-risk histopathological features, and lethal recurrence rates.
abstract: BACKGROUND
  Mucinous and serous borderline ovarian tumours (mBOTs and sBOTs) are controversial diseases.
  
  
  OBJECTIVE
  With this systematic review we aim to evaluate the different high-risk histopathological features and recurrence rates.
  
  
  METHODS
  The PubMed database was searched using two terms: {serous AND [(borderline) OR (low malignant potential)] AND ovarian AND tumour} and {mucinous AND [(borderline) OR (low malignant potential)] AND ovarian AND tumour}.
  
  
  METHODS
  Cohorts of either sBOT or mBOT, peer-reviewed, retrospective, or prospective.
  
  
  METHODS
  Lethal recurrence data for micropapillary patterns (MPs), microinvasion, non-invasive and invasive implants, and intraepithelial carcinoma (IECA). The primary measure of effect was the odds ratio of lethal recurrence reduction.
  
  
  RESULTS
  Data from patients in 42 studies including 4414 sBOTs and 12 studies including 894 mBOTs were pooled. Of these, 53.3% presented early-stage typical sBOTs, 24.4% presented with MPs, 22.3% presented with microinvasion, 34.4% presented with non-invasive implants, and 7.3% presented with invasive implants. The pooled lethal recurrence rates were, respectively: 18.3, 16.8, 10.7, 16.2, and 33.8%. Patients with MPs were more likely to suffer lethal recurrence when compared with high-stage sBOTs (odds ratio, OR 0.501; P = 0.003), whereas the trend in microinvasive sBOTs did not reach statistical significance. Regarding mBOTs, 61.6% presented with early-stage typical mBOTs, 19.6% presented with microinvasion, 34.8% presented with IECA, and six patients presented with non-invasive implants; none presented with invasive implants. The lethal recurrence rates were, respectively: 3.6, 0, 3.7, and 0%.
  
  
  CONCLUSIONS
  Micropapillary patterns (MPs) showed a higher risk for lethal recurrence when compared with high-stage sBOTs. Regarding mBOTs, IECA and microinvasion do not play a role in the lethal recurrence rate.
  
  
  CONCLUSIONS
  Micropapillary pattern confirmed as high-risk in BOT. IECA and microinvasion don't play a role in mucinous BOT.
authors.affiliation: Department of Gynaecology, Charité Medical University of Berlin, Campus Virchow Klinikum, Berlin, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Vasconcelos
authors.affiliation: Department of Pathology, Charité Medical University of Berlin, Campus Virchow Klinikum, Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Darb-Esfahani
authors.affiliation: Department of Gynaecology, Charité Medical University of Berlin, Campus Virchow Klinikum, Berlin, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Sehouli
mesh_terms: D002278:Carcinoma in Situ / Q000401:mortality* / Q000473:pathology*; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000401:mortality* / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000401:mortality* / Q000473:pathology*; D010052:Ovariectomy; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D058994:Salpingectomy; D013997:Time Factors
keywords: Intraepithelial carcinoma; invasive implants; microinvasive borderline ovarian tumours; micropapillary serous borderline ovarian tumours; mucinous borderline ovarian tumours; non-invasive implants