title: Potential drawbacks in cell-assisted lipotransfer: A systematic review of existing reports (Review).
abstract: Cell-assisted lipotransfer (CAL) has been widely used in various clinical applications, including breast augmentation following mammectomy, soft-tissue reconstruction and wound healing. However, the clinical application of CAL has been restricted due to the transplanted fat tissues being readily liquefied and absorbed. The present review examines 57 previously published studies involving CAL, including fat grafting or fat transfer with human adipose-stem cells in all known databases. Of these 57 articles, seven reported the clinical application of CAL. In the 57 studies, the majority of the fat tissues were obtained from the abdomen via liposuction of the seven clinical studies, four were performed in patients requiring breast augmentation, one in a patient requiring facial augmentation, one in a patient requiring soft tissue augmentation/reconstruction and one in a patient requiring fat in their upper arms. Despite the potential risks, there has been an increased demand for CAL in in cosmetic or aesthetic applications. Thus, criteria and guidelines are necessary for the clinical application of CAL technology.
authors.affiliation: Department of Plastic and Reconstructive Surgery, General Hospital of Shenyang Military Area Command, Shenyang, Liaoning 110840, P.R. China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
authors.forename: Weiliang
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Plastic and Reconstructive Surgery, General Hospital of Shenyang Military Area Command, Shenyang, Liaoning 110840, P.R. China.
authors.forename: Zihua
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Plastic and Reconstructive Surgery, General Hospital of Shenyang Military Area Command, Shenyang, Liaoning 110840, P.R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Tao
authors.affiliation: Department of Plastic and Reconstructive Surgery, General Hospital of Shenyang Military Area Command, Shenyang, Liaoning 110840, P.R. China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Plastic and Reconstructive Surgery, General Hospital of Shenyang Military Area Command, Shenyang, Liaoning 110840, P.R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Chang
mesh_terms: D000273:Adipose Tissue / Q000166:cytology; D002469:Cell Separation; D006801:Humans; D015187:Lipectomy / Q000009:adverse effects; D011182:Postoperative Care; D012307:Risk Factors; D013234:Stem Cells / Q000166:cytology