title: Polyphenols, antioxidants, and antimutagenic effects of Copaifera langsdorffii fruit.
abstract: Copaifera langsdorffii (copaiba) is a Brazilian exotic fruit, poorly studied regarding its bioactive composition. The aim of this study was to determine bioactive compounds, antioxidant and antimutagenic activities of copaiba pulp. The samples were extracted with different solvents in order to analyze polyphenol compounds (Folin Ciocalteau and HPLC-DAD), total flavonoids (reaction with AlCl3) and antioxidant capacity (FRAP, ORAC, DPPH). The copaiba fruit showed high polyphenol content and antioxidant capacity. Phenolic compounds, such as gallic acid, epicatechin gallate, catechin, epicatechin and isoquercitrin, were identified in the copaiba pulp. Despite the antioxidant capacity, the highest dose of copaiba showed no antimutagenic effects in the in vivo study. The dose which showed antimutagenic activity was 100 mg kg(-1).
authors.affiliation: School of Food Engineering, University of Campinas (UNICAMP), P.O. Box 6121, 13083-862 Campinas-SP, Brazil.
authors.forename: Ângela Giovana
authors.initials: ÂG
authors.lastname: Batista
authors.affiliation: School of Nutrition, Federal University of Alfenas, MG (UNIFAL-MG), Brazil.
authors.forename: Angélica Simões
authors.initials: AS
authors.lastname: Ferrari
authors.affiliation: School of Nutrition, Federal University of Alfenas, MG (UNIFAL-MG), Brazil.
authors.forename: Débora Cristina
authors.initials: DC
authors.lastname: da Cunha
authors.affiliation: School of Food Engineering, University of Campinas (UNICAMP), P.O. Box 6121, 13083-862 Campinas-SP, Brazil.
authors.forename: Juliana Kelly
authors.initials: JK
authors.lastname: da Silva
authors.affiliation: School of Food Engineering, University of Campinas (UNICAMP), P.O. Box 6121, 13083-862 Campinas-SP, Brazil.
authors.forename: Cinthia Baú Betim
authors.initials: CB
authors.lastname: Cazarin
authors.affiliation: Brazilian Agricultural Research Corporation, Embrapa Tropical Semi-arid, Petrolina, Pernambuco 56302-970, Brazil.
authors.forename: Luiz Claudio
authors.initials: LC
authors.lastname: Correa
authors.affiliation: School of Food Engineering, University of Campinas (UNICAMP), P.O. Box 6121, 13083-862 Campinas-SP, Brazil.
authors.forename: Marcelo Alexandre
authors.initials: MA
authors.lastname: Prado
authors.affiliation: School of Nutrition, Federal University of Alfenas, MG (UNIFAL-MG), Brazil.
authors.forename: Luciano Bruno de
authors.initials: LB
authors.lastname: Carvalho-Silva
authors.affiliation: Nutrition Department, Federal University of Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Minas Gerais, Brazil.
authors.forename: Elizabethe Adriana
authors.initials: EA
authors.lastname: Esteves
authors.affiliation: School of Food Engineering, University of Campinas (UNICAMP), P.O. Box 6121, 13083-862 Campinas-SP, Brazil. Electronic address: mario@fea.unicamp.br.
authors.forename: Mário Roberto
authors.initials: MR
authors.lastname: Maróstica Júnior
mesh_terms: D016587:Antimutagenic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001938:Brazil; D007887:Fabaceae / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D059808:Polyphenols / Q000032:analysis*
chemical_list: D016587:Antimutagenic Agents; D000975:Antioxidants; D010936:Plant Extracts; D059808:Polyphenols
keywords: (+)-Catechin (PubChem CID: 964); (−)-Epicatechin (PubChem CID: 72276); (−)-Epicatechin gallate (PubChem CID: 367141); Antioxidant capacity; Copaiba; Gallic acid; Gallic acid (PubChem CID: 370); Isoquercitrin (PubChem CID: 5280804); Micronuclei