title: Highly efficient synthesis of flavonol 5-O-glycosides with glycosyl ortho-alkynylbenzoates as donors.
abstract: With glycosyl ortho-alkynylbenzoates as donors, the highly efficient glycosylation of flavonoid 5-OH which are notorious for their low reactivity due to their involvement in the formation of strong intramolecular H-bonds was achieved under the catalysis of a Au(i) complex. Thus, a series of flavonoid 5-O-glycosides, including a kaempferol 5-O-disaccharide, were synthesized with good to excellent yields.
authors.affiliation: The National Engineering Research Center for Carbohydrate Synthesis, Jianxi Normal University, Nanchang 330022, China. jssun@jxnu.edu.cn.
authors.forename: Jin-Xi
authors.initials: JX
authors.lastname: Liao
authors.forename: Nai-Li
authors.initials: NL
authors.lastname: Fan
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Yuan-Hong
authors.initials: YH
authors.lastname: Tu
authors.forename: Jian-Song
authors.initials: JS
authors.lastname: Sun
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001565:Benzoates / Q000737:chemistry*; D044948:Flavonols / Q000138:chemical synthesis* / Q000737:chemistry; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D015394:Molecular Structure
chemical_list: D000480:Alkynes; D001565:Benzoates; D044948:Flavonols; D006027:Glycosides