title: Characterization of Th17 and FoxP3(+) Treg Cells in Paediatric Psoriasis Patients.
abstract: Psoriasis is one of the most common inflammatory skin conditions affecting both children and adults. Growing evidence indicates that T-helper 17 (Th17) cells and CD4(+) CD25(+) regulatory T (Treg) cells play an important role in the pathogenesis of psoriasis. However, the relationship between Th17 and Treg cells and their dynamic variations in paediatric psoriasis remain unclear. In this study, we found that both Th17 and FoxP3(+) Treg cells and the ratio of Th17 to Treg cell frequency in the peripheral circulation were increased in patients with paediatric psoriasis and were positively correlated with the disease severity. The function of Treg to suppress CD4(+) CD25(-) T cell proliferation and IFN-γ secretion was impaired during the onset of psoriasis. After disease remission, both the Th17 and Treg cell frequencies were decreased, and the suppressive function of the Treg cells was obviously restored. However, neither Treg cells from the disease onset nor those after remission can regulate IL-17 secretion by CD4(+) T cells. These findings will further our understanding of the associations between Th17 and Treg cells in paediatric psoriasis and their influence on disease severity.
authors.affiliation: Department of Dermatology, Affiliated hospital of Academy of Military Medical Sciences, Beijing, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Affiliated hospital of Academy of Military Medical Sciences, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Dermatology, Air Force General Hospital of Chinese PLA, Beijing, China.
authors.forename: X
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Dermatology, Affiliated hospital of Academy of Military Medical Sciences, Beijing, China.
authors.forename: J
authors.initials: J
authors.lastname: Wei
authors.affiliation: Department of Laser Medicine, Chinese PLA General Hospital, Beijing, China.
authors.forename: S
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Dermatology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Dermatology, Beijing 302 hospital, Beijing, China.
authors.forename: J
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Department of Dermatology, Beijing 302 hospital, Beijing, China.
authors.forename: H
authors.initials: H
authors.lastname: Duan
authors.affiliation: The school of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, Qld, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Jia
authors.affiliation: Department of Pediatrics, Affiliated hospital of Academy of Military Medical Sciences, Beijing, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Lei
authors.affiliation: Department of Ophthalmology, Affiliated hospital of Academy of Military Medical Sciences, Beijing, China.
authors.forename: J
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Pediatrics, Affiliated hospital of Academy of Military Medical Sciences, Beijing, China.
authors.forename: C
authors.initials: C
authors.lastname: Feng
mesh_terms: D000293:Adolescent; D049109:Cell Proliferation; D002469:Cell Separation; D002478:Cells, Cultured; D002648:Child; D005260:Female; D005434:Flow Cytometry; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D020381:Interleukin-17 / Q000378:metabolism; D008297:Male; D011565:Psoriasis / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D020381:Interleukin-17; D007371:Interferon-gamma