title: Complex film of chitosan and carboxymethyl cellulose nanofibers.
abstract: A polymer film composed of a mixture of chitosan (Ch) and carboxymethyl cellulose sodium salt (CMC) nanofibers was deposited on a glass surface. The thin film of the Ch-CMC mixture obtained was stable, and fibroblast adhesion to the film was lowest when the weight ratio of Ch to CMC was 4:6. The ζ-potential and contact angle of the mixture film indicated that a polyion complex of Ch and CMC was formed. The mechanical strength of the film composed of Ch-CMC nanofiber complexes was much higher than that of the film composed of Ch-water-soluble CMC complexes (non-nanofiber), likely because the entanglement of nanofibers was enhanced by electrostatic attractions. These results indicate that the charge-neutralized nanofiber film was highly effective in suppressing cell adhesion and therefore is a promising material for biomedical applications.
authors.affiliation: Department of Applied Chemistry, Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama-shi, Toyama 930-8555, Japan.
authors.forename: Takuma
authors.initials: T
authors.lastname: Kawasaki
authors.affiliation: Department of Applied Chemistry, Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama-shi, Toyama 930-8555, Japan; Frontier Research Core for Life Sciences, University of Toyama, 3190 Gofuku, Toyama-shi, Toyama 930-8555, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nakaji-Hirabayashi
authors.affiliation: Department of Applied Chemistry, Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama-shi, Toyama 930-8555, Japan.
authors.forename: Kazuhira
authors.initials: K
authors.lastname: Masuyama
authors.affiliation: Department of Fiber Technology and Sciences, Graduate School of Engineering, University of Fukui, 3-9-1 Bunkyo, Fukui-shi, Fukui 910-8507, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujita
authors.affiliation: Department of Applied Chemistry, Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama-shi, Toyama 930-8555, Japan. Electronic address: kitano@eng.u-toyama.ac.jp.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kitano
mesh_terms: D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D041681:NIH 3T3 Cells; D057139:Nanofibers / Q000737:chemistry*; D055672:Static Electricity; D013499:Surface Properties; D013718:Tensile Strength / Q000187:drug effects
chemical_list: D048271:Chitosan; D002266:Carboxymethylcellulose Sodium
keywords: Anti-biofouling; Carboxymethyl cellulose; Chitosan; Nanofiber film; Polyion complex