title: Efficacy of parathyroid hormone supplementation on the osseointegration of implants: a systematic review.
abstract: OBJECTIVE
  The aim of the present systematic review was to assess the efficacy of parathyroid hormone supplementation on the osseointegration of implants.
  
  
  METHODS
  The addressed focused question was Does parathyroid hormone supplementation affect osseointegration around implants? Indexed databases were searched from 1965 up to and including April 2015 using various key words including: Bone to implant contact; implant; parathyroid hormone; and osseointegration. Letters to the Editor, case-reports/case-series, historic reviews, commentaries and articles published in languages other than English were excluded. The pattern of the present systematic review was customized to primarily summarize the pertinent data.
  
  
  RESULTS
  Eighteen studies fulfilled the eligibility criteria. Evidence was limited to preclinical animal studies only (11 studies in rodents, 4 in dogs and 3 in rabbits). Number of titanium implants placed ranged between 20 and 80 implants. Results from 16 studies showed that PTH supplementation enhanced new bone formation and/or BIC around implants. One study suggests that PTH-coated implants improve BIC and BA. One study showed no significant difference in BIC and new bone formation around implants with PTH hydrogel placement.
  
  
  CONCLUSIONS
  Efficacy of PTH supplementation on osseointegration of implants shows promising results in animal models, however further investigation is necessary to assess the effectiveness in humans.
authors.affiliation: Division of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA. Fawad_Javed@urmc.rochester.edu.
authors.forename: Fawad
authors.initials: F
authors.lastname: Javed
authors.affiliation: Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Mohammad D
authors.initials: MD
authors.lastname: Al Amri
authors.affiliation: Division of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
authors.forename: Sergio Varela
authors.initials: SV
authors.lastname: Kellesarian
authors.affiliation: Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh, 11541, Saudi Arabia.
authors.forename: Abdulaziz A
authors.initials: AA
authors.lastname: Al-Kheraif
authors.affiliation: Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Fahim
authors.initials: F
authors.lastname: Vohra
authors.affiliation: Faculty of Medicine and Dentistry, University of Murcia, Hospital Morales Meseguer, 2° Planta Clínica Odontológica Calle Marques de los Velez S/n, 30007, Murcia, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Calvo-Guirado
authors.affiliation: Division of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
authors.forename: Hans
authors.initials: H
authors.lastname: Malmstrom
authors.affiliation: Division of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.|Department of Periodontology, School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA.|Department of Oral Surgery and Implant Dentistry, Dental School, Johann Wolfgang Goethe, University of Frankfurt, Frankfurt, Germany.
authors.forename: Georgios E
authors.initials: GE
authors.lastname: Romanos
mesh_terms: D000818:Animals; D015921:Dental Implants; D004285:Dogs; D006801:Humans; D016348:Osseointegration; D010281:Parathyroid Hormone; D019736:Prostheses and Implants; D014025:Titanium
chemical_list: D015921:Dental Implants; D010281:Parathyroid Hormone; D014025:Titanium
keywords: Bone to implant contact; Implant; Osseointegration; Parathyroid hormone