title: RIFM fragrance ingredient safety assessment, Benzyl propionate, CAS Registry Number 122-63-4.
abstract: The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 14.5 mg/kg/day. A dietary 2-year chronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 1318 while considering 78.7% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. Electronic address: AApi@rifm.org.
authors.forename: A M
authors.initials: AM
authors.lastname: Api
authors.affiliation: Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY 10032, USA.
authors.forename: D
authors.initials: D
authors.lastname: Belsito
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: S
authors.initials: S
authors.lastname: Bhatia
authors.affiliation: Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo SE-20502, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Bruze
authors.affiliation: Humphrey School of Public Affairs, University of Minnesota, 301 19th Avenue South, Minneapolis, MN 55455, USA.
authors.forename: P
authors.initials: P
authors.lastname: Calow
authors.affiliation: University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo CEP 05508-900, Brazil.
authors.forename: M L
authors.initials: ML
authors.lastname: Dagli
authors.affiliation: University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078 Würzburg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Dekant
authors.affiliation: Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Fryer
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: L
authors.initials: L
authors.lastname: Kromidas
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: S
authors.initials: S
authors.lastname: La Cava
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Lalko
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: A
authors.initials: A
authors.lastname: Lapczynski
authors.affiliation: Vanderbilt University School of Medicine, Department of Biochemistry, Center in Molecular Toxicology, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN 37232-0146, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Liebler
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: V T
authors.initials: VT
authors.lastname: Politano
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: G
authors.initials: G
authors.lastname: Ritacco
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: D
authors.initials: D
authors.lastname: Salvito
authors.affiliation: The University of Tennessee, College of Veterinary Medicine, Department of Comparative Medicine, 2407 River Dr., Knoxville, TN 37996-4500, USA.
authors.forename: T W
authors.initials: TW
authors.lastname: Schultz
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: J
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ 85724-5050, USA.
authors.forename: I G
authors.initials: IG
authors.lastname: Sipes
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: B
authors.initials: B
authors.lastname: Wall
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
authors.forename: D K
authors.initials: DK
authors.lastname: Wilcox
mesh_terms: D000818:Animals; D001593:Benzyl Compounds / Q000737:chemistry / Q000633:toxicity*; D003257:Consumer Product Safety; D004249:DNA Damage / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D023381:Endpoint Determination; D019055:No-Observed-Adverse-Effect Level; D010476:Perfume / Q000737:chemistry / Q000633:toxicity*; D011422:Propionates / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D018570:Risk Assessment; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D001593:Benzyl Compounds; D010476:Perfume; D011422:Propionates