title: Minimally invasive surgical approach to pancreatic malignancies.
abstract: Pancreatic surgery for malignancy is recognized as challenging for the surgeons and risky for the patients due to consistent perioperative morbidity and mortality. Furthermore, the oncological long-term results are largely disappointing, even for those patients who experience an uneventfully hospital stay. Nevertheless, surgery still remains the cornerstone of a multidisciplinary treatment for pancreatic cancer. In order to maximize the benefits of surgery, the advent of both laparoscopy and robotics has led many surgeons to treat pancreatic cancers with these new methodologies. The reduction of postoperative complications, length of hospital stay and pain, together with a shorter interval between surgery and the beginning of adjuvant chemotherapy, represent the potential advantages over conventional surgery. Lastly, a better cosmetic result, although not crucial in any cancerous patient, could also play a role by improving overall well-being and patient self-perception. The laparoscopic approach to pancreatic surgery is, however, difficult in inexperienced hands and requires a dedicated training in both advanced laparoscopy and pancreatic surgery. The recent large diffusion of the da Vinci(®) robotic platform seems to facilitate many of the technical maneuvers, such as anastomotic biliary and pancreatic reconstructions, accurate lymphadenectomy, and vascular sutures. The two main pancreatic operations, distal pancreatectomy and pancreaticoduodenectomy, are approachable by a minimally invasive path, but more limited interventions such as enucleation are also feasible. Nevertheless, a word of caution should be taken into account when considering the increasing costs of these newest technologies because the main concerns regarding these are the maintenance of all oncological standards and the lack of long-term follow-up. The purpose of this review is to examine the evidence for the use of minimally invasive surgery in pancreatic cancer (and less aggressive tumors), with particular attention to the oncological results and widespread reproducibility of each technique.
authors.affiliation: Lapo Bencini, Mario Annecchiarico, Marco Farsi, Ilenia Bartolini, Vita Mirasolo, Francesco Guerra, Andrea Coratti, Department of Oncology, Division of Surgical Oncology and Robotics, Careggi University Hospital, 50131 Florence, Italy.
authors.forename: Lapo
authors.initials: L
authors.lastname: Bencini
authors.affiliation: Lapo Bencini, Mario Annecchiarico, Marco Farsi, Ilenia Bartolini, Vita Mirasolo, Francesco Guerra, Andrea Coratti, Department of Oncology, Division of Surgical Oncology and Robotics, Careggi University Hospital, 50131 Florence, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Annecchiarico
authors.affiliation: Lapo Bencini, Mario Annecchiarico, Marco Farsi, Ilenia Bartolini, Vita Mirasolo, Francesco Guerra, Andrea Coratti, Department of Oncology, Division of Surgical Oncology and Robotics, Careggi University Hospital, 50131 Florence, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Farsi
authors.affiliation: Lapo Bencini, Mario Annecchiarico, Marco Farsi, Ilenia Bartolini, Vita Mirasolo, Francesco Guerra, Andrea Coratti, Department of Oncology, Division of Surgical Oncology and Robotics, Careggi University Hospital, 50131 Florence, Italy.
authors.forename: Ilenia
authors.initials: I
authors.lastname: Bartolini
authors.affiliation: Lapo Bencini, Mario Annecchiarico, Marco Farsi, Ilenia Bartolini, Vita Mirasolo, Francesco Guerra, Andrea Coratti, Department of Oncology, Division of Surgical Oncology and Robotics, Careggi University Hospital, 50131 Florence, Italy.
authors.forename: Vita
authors.initials: V
authors.lastname: Mirasolo
authors.affiliation: Lapo Bencini, Mario Annecchiarico, Marco Farsi, Ilenia Bartolini, Vita Mirasolo, Francesco Guerra, Andrea Coratti, Department of Oncology, Division of Surgical Oncology and Robotics, Careggi University Hospital, 50131 Florence, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Guerra
authors.affiliation: Lapo Bencini, Mario Annecchiarico, Marco Farsi, Ilenia Bartolini, Vita Mirasolo, Francesco Guerra, Andrea Coratti, Department of Oncology, Division of Surgical Oncology and Robotics, Careggi University Hospital, 50131 Florence, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Coratti
keywords: Da Vinci; Laparoscopic; Neuroendocrine pancreatic tumors; Pancreatic adenocarcinoma; Pancreatic cancer; Robotic