title: Roles for mismatch repair family proteins in promoting meiotic crossing over.
abstract: The mismatch repair (MMR) family complexes Msh4-Msh5 and Mlh1-Mlh3 act with Exo1 and Sgs1-Top3-Rmi1 in a meiotic double strand break repair pathway that results in the asymmetric cleavage of double Holliday junctions (dHJ) to form crossovers. This review discusses how meiotic roles for Msh4-Msh5 and Mlh1-Mlh3 do not fit paradigms established for post-replicative MMR. We also outline models used to explain how these factors promote the formation of meiotic crossovers required for the accurate segregation of chromosome homologs during the Meiosis I division.
authors.affiliation: Department of Molecular Biology and Genetics, Cornell University, 457 Biotechnology Building, Ithaca, NY 14853-2703, USA.
authors.forename: Carol M
authors.initials: CM
authors.lastname: Manhart
authors.affiliation: Department of Molecular Biology and Genetics, Cornell University, 457 Biotechnology Building, Ithaca, NY 14853-2703, USA. Electronic address: eea3@cornell.edu.
authors.forename: Eric
authors.initials: E
authors.lastname: Alani
mesh_terms: D000818:Animals; D003434:Crossing Over, Genetic; D053843:DNA Mismatch Repair; D045566:DNA, Cruciform / Q000378:metabolism; D006801:Humans; D008540:Meiosis; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000378:metabolism*
chemical_list: D045566:DNA, Cruciform; D046912:Multiprotein Complexes
keywords: Crossing over; Holliday junction resolution; Meiosis; Mlh1-Mlh3; Msh4-Msh5