title: Beneath the Copper-Pediatric Wilson's Disease Cirrhosis and Hepatocellular Carcinoma: A Case Report with Literature Review.
abstract: Primary hepatic malignancies are uncommon in pediatrics. Tumors such as hepatocellular carcinoma (HCC) develop typically in the setting of chronic liver disease. The incidence of HCC in Wilson's disease-related cirrhosis is disproportionately lower than in many other forms of end-stage liver disease. A preadolescent girl presented with Wilson's disease cirrhosis and a HCC requiring orthotopic liver transplantation. This case highlights the need to consider hepatic malignancies even in young Wilson's disease patients. Pediatric Wilson's disease and the hepatic tumor literature are reviewed.
authors.affiliation: Department of Pediatrics, Section of Gastroenterology and Hepatobiliary Diseases, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Rosencrantz
authors.affiliation: Department of Radiology, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York.
authors.forename: Lesli
authors.initials: L
authors.lastname: LeCompte
authors.affiliation: Department of Pathology, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York.
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Yusuf
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D002570:Ceruloplasmin / Q000378:metabolism*; D002648:Child; D005260:Female; D006527:Hepatolenticular Degeneration / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D016031:Liver Transplantation; D012805:Sickle Cell Trait / Q000150:complications; D014463:Ultrasonography
chemical_list: D002570:Ceruloplasmin