title: Rapid Reversible Photoswitching of Integrin-Mediated Adhesion at the Single-Cell Level.
abstract: Rapid and reversible photoswitching of cell adhesion is achieved by c(RGDfK)-azobenzenes embedded in a poly(ethylene glycol) background on surfaces. The light-induced cis-trans-isomerization of the azobenzene enables switching of cell adhesion on the surface. Reversibility of switching over several consecutive switching cycles is demonstrated by single-cell force spectroscopy.
authors.affiliation: Institute for Materials Science, University of Kiel, Kaiserstr. 2, 24143, Kiel, Germany.
authors.forename: Laith F
authors.initials: LF
authors.lastname: Kadem
authors.affiliation: Otto-Diels-Institute of Organic Chemistry, University of Kiel, Otto-Hahn-Platz 4, 24098, Kiel, Germany.
authors.forename: Michelle
authors.initials: M
authors.lastname: Holz
authors.affiliation: Otto-Diels-Institute of Organic Chemistry, University of Kiel, Otto-Hahn-Platz 4, 24098, Kiel, Germany.
authors.forename: Kristine Grace
authors.initials: KG
authors.lastname: Suana
authors.affiliation: Institute for Materials Science, University of Kiel, Kaiserstr. 2, 24143, Kiel, Germany.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: Institute for Materials Science, University of Kiel, Kaiserstr. 2, 24143, Kiel, Germany.
authors.forename: Constanze
authors.initials: C
authors.lastname: Lamprecht
authors.affiliation: Otto-Diels-Institute of Organic Chemistry, University of Kiel, Otto-Hahn-Platz 4, 24098, Kiel, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Herges
authors.affiliation: Institute for Materials Science, University of Kiel, Kaiserstr. 2, 24143, Kiel, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Selhuber-Unkel
mesh_terms: D001391:Azo Compounds / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D016023:Integrins / Q000378:metabolism*; D008027:Light; D010456:Peptides, Cyclic / Q000737:chemistry; D059010:Single-Cell Analysis; D013499:Surface Properties
chemical_list: D001391:Azo Compounds; D016023:Integrins; D010456:Peptides, Cyclic; C099250:cyclic (arginyl-glycyl-aspartyl-phenylalanyl-lysyl); C009850:azobenzene
keywords: atomic force microscopy; cell adhesion; integrin; photoswitching; surface chemistry