title: Chemical composition and antifungal activity of essential oil from Eucalyptus smithii against dermatophytes.
abstract: BACKGROUND
  In this study, we evaluated the chemical composition of a commercial sample of essential oil from Eucalyptus smithii R.T. Baker and its antifungal activity against Microsporum canis ATCC 32903, Microsporum gypseum ATCC 14683, Trichophyton mentagrophytes ATCC 9533, T. mentagrophytes ATCC 11480, T. mentagrophytes ATCC 11481, and Trichophyton rubrum CCT 5507.
  
  
  METHODS
  Morphological changes in these fungi after treatment with the oil were determined by scanning electron microscopy (SEM). The antifungal activity of the oil was determined on the basis of minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values.
  
  
  RESULTS
  The compound 1,8-cineole was found to be the predominant component (72.2%) of the essential oil. The MIC values of the oil ranged from 62.5μg·mL-1 to >1,000μg·mL-1, and the MFC values of the oil ranged from 125μg·mL-1 to >1,000μg·mL-1. SEM analysis showed physical damage and morphological alterations in the fungi exposed to this oil.
  
  
  CONCLUSIONS
  We demonstrated the potential of Eucalyptus smithii essential oil as a natural therapeutic agent for the treatment of dermatophytosis.
authors.affiliation: Núcleo de Pesquisa e Inovação em Ciências da Saúde, Faculdade de Farmácia, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
authors.forename: Edilene Bolutari
authors.initials: EB
authors.lastname: Baptista
authors.affiliation: Núcleo de Pesquisa e Inovação em Ciências da Saúde, Faculdade de Farmácia, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
authors.forename: Danielle Cristina
authors.initials: DC
authors.lastname: Zimmermann-Franco
authors.affiliation: Núcleo de Pesquisa e Inovação em Ciências da Saúde, Faculdade de Farmácia, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
authors.forename: Alexandre Augusto Barros
authors.initials: AA
authors.lastname: Lataliza
authors.affiliation: Núcleo de Pesquisa e Inovação em Ciências da Saúde, Faculdade de Farmácia, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
authors.forename: Nádia Rezende Barbosa
authors.initials: NR
authors.lastname: Raposo
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005052:Eucalyptus / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D008864:Microsporum / Q000145:classification / Q000187:drug effects* / Q000648:ultrastructure; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D014249:Trichophyton / Q000145:classification / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D000935:Antifungal Agents; D009822:Oils, Volatile; D010936:Plant Extracts