title: One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process.
abstract: Difluoromethyl ketones are an under-studied class of ketones which have great potential as useful building blocks for materials and drug design. Here we report a simple and convenient synthesis of this class of compounds via a one-pot difluorination/fragmentation of 1-trifluoromethyl-1,3-diketones which should now allow the chemistry of difluoromethyl ketones to be fully developed.
authors.affiliation: Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. graham.pattison@warwick.ac.uk.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Leng
authors.affiliation: Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. graham.pattison@warwick.ac.uk.
authors.forename: Conor M
authors.initials: CM
authors.lastname: Black
authors.affiliation: Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. graham.pattison@warwick.ac.uk.
authors.forename: Graham
authors.initials: G
authors.lastname: Pattison