title: Polypyrrole Composite Nanoparticles with Morphology-Dependent Photothermal Effect and Immunological Responses.
abstract: Polypyrrole composite nanoparticles with controlled shape are synthesized, which exhibit a morphology-dependent photothermal effect: the raspberry-like composite nanoparticles have a much better photothermal effect than the spherical ones, and the immune responses to the nanocomposites are also dependent on their morphology. The outstanding performance of the nanocomposites promises their potential application in photothermal therapy and immunotherapy of cancer.
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200433, P. R. China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Surface Physics, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education) and Collaborative Innovation Center of Advanced Microstructures, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Shiwei
authors.initials: S
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Surface Physics, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education) and Collaborative Innovation Center of Advanced Microstructures, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Wuli
authors.initials: W
authors.lastname: Yang
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival; D003713:Dendritic Cells / Q000378:metabolism; D006801:Humans; D006979:Hyperthermia, Induced; D007109:Immunity; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010789:Phototherapy; D011108:Polymers / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013696:Temperature
chemical_list: D015703:Antigens, CD; D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole
keywords: immunotherapy; morphology; nanoparticles; photothermal therapy; polypyrrole