title: [Adult height of children with idiopathic short stature treated with growth hormone therapy].
abstract: BACKGROUND
  Idiopathic short stature (ISS) is defined as a height of < or = 2 standard deviations (SD) from the mean for age. The use of Growth Hormone (GH) in ISS is controversial, and there are not results for adult height (AH) in Chilean patients with ISS treated with GH. The objective of the study is to compare AH in patients treated with GH with the height prediction at beginning of treatment.
  
  
  METHODS
  AH was considered with bone age ≥ 17 in males and ≥15 in females. The height SD according to the NCHS curves at beginning and ending of treatment were used for the comparison. Height prediction (HP) was calculated by Bayley-Pinneau method.
  
  
  RESULTS
  AH was reached by 18/47 patients with ISS treated with GH. Initial height -2.1 ± 0.85 SD (133.1±6.8 cm) and HP -1.94±0.86 SD, and were treated since 11.6 ± 1.2 years old. After one year of treatment their height was -1.64 ± 0.69 SD, and AH was -1.28 +/- 0.62 SD (163.76 +/- 7.22 cm).
  
  
  CONCLUSIONS
  It is suggested that treatment with GH for ISS is effective to increase AH. Although with wide individual variability, a mean increase of 0.67±0.9 SD (+2.67 cm) was obtained in the AH. This is the first report on Adult Height in Chilean patients.
authors.affiliation: Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Carolina
authors.initials: C
authors.lastname: Avilés Espinoza
authors.affiliation: Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Carla
authors.initials: C
authors.lastname: Bermúdez Melero
authors.affiliation: Unidad de Endocrinología, División de Pediatría, Hospital Clínico de la Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Martinez Aguayo
authors.affiliation: Unidad de Endocrinología, División de Pediatría, Hospital Clínico de la Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address: hgarciab@med.puc.cl.
authors.forename: Hernán
authors.initials: H
authors.lastname: García Bruce
mesh_terms: D000293:Adolescent; D001827:Body Height / Q000187:drug effects*; D002648:Child; D002677:Chile; D005260:Female; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D019382:Human Growth Hormone
keywords: Alteraciones del crecimiento; Body height; Growth disorders; Hormona del crecimiento; Idiopathic short stature; Resultado del tratamiento con hormona del crecimiento; Talla baja idiopática; Treatment outcome Growth Hormone