title: [Narrow band imaging for early diagnosis of epithelial dysplasias and microinvasive tumors in the upper aerodigestive tract].
abstract: The various stages of tumor growth are characterized by typical epithelial, vascular, and secondary connective tissue changes. Narrow band imaging (NBI) endoscopy is a minimally invasive imaging technique that presents vascular structures in particular at a higher contrast than white light endoscopy alone. In combination with high-resolution image recording and reproduction (high-definition television, HDTV; ultra-high definition, 4K), progress has been made in otolaryngological differential diagnostics, both pre- and intraoperatively. This progress represents an important step towards a so-called optical biopsy. Flexible endoscopy in combination with NBI allows detailed assessment of areas of the upper aerodigestive tract which are difficult to assess by rigid endoscopy. Papillomas, precancerous, and cancerous lesions are characterized by epithelial and connective tissue changes, as well as by typical perpendicular vascular changes. Systematic use of NBI is recommended in the differential diagnosis of malignant lesions of the upper aerodigestive tract. NBI also convinces by a significant improvement in pre- and intraoperative assessment of superficial resection margins. In particular, the combination of NBI and contact endoscopy (compact endoscopy) permits excellent therapeutic decisions during tumor surgery. Intraoperative determination of resection margins at unprecedented precision is possible. In addition, assessment of the form and extent of the perpendicular vessel loops stimulated by epithelial signaling enables differential diagnostic decisions to be made, approximating our goal of an optical biopsy.
authors.affiliation: Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Magdeburg A. ö .R., Otto-von-Guericke-Universität Magdeburg, Leipziger Straße 44, 39120, Magdeburg, Deutschland. christoph.arens@med.ovgu.de.
authors.forename: C
authors.initials: C
authors.lastname: Arens
authors.affiliation: Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde, Klinikum Großhadern, Ludwig-Maximilian-Universität, München, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Betz
authors.affiliation: Klinik für Hals-, Nasen- und Ohrenheilkunde, Hals- und Gesichtschirurgie, Kantonsspital Baselland, Liestal, Schweiz.
authors.forename: M
authors.initials: M
authors.lastname: Kraft
authors.affiliation: Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Magdeburg A. ö .R., Otto-von-Guericke-Universität Magdeburg, Leipziger Straße 44, 39120, Magdeburg, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Voigt-Zimmermann
mesh_terms: D055088:Early Detection of Cancer / Q000379:methods*; D004724:Endoscopy / Q000379:methods*; D005770:Gastrointestinal Neoplasms / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008029:Lighting / Q000379:methods; D009361:Neoplasm Invasiveness; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology*; D012142:Respiratory Tract Neoplasms / Q000473:pathology*; D041622:Tomography, Optical / Q000379:methods*
keywords: Compactendoscopy; Endoscopic imaging; Neoplasms; Precancerous lesions; Vascular lesions