title: HBF4-Catalysed Nucleophilic Substitutions of Propargylic Alcohols.
abstract: The activity of HBF4(aqueous solution) as a catalyst in propargylation reactions is presented. Diverse types of nucleophiles were employed in order to form new C-O, C-N and C-C bonds in technical acetone and in air. Good to excellent yields and good chemoselectivities were obtained using low acid loading (typically 1 mol-%) under simple reaction conditions.
authors.affiliation: Department of Chemistry, Imperial College London Exhibition Road South Kensington, London SW7 2AZ, UK , http://www3.imperial.ac.uk/diez-gonzalezgroup.
authors.forename: Elena
authors.initials: E
authors.lastname: Barreiro
authors.affiliation: Department of Chemistry, Imperial College London Exhibition Road South Kensington, London SW7 2AZ, UK , http://www3.imperial.ac.uk/diez-gonzalezgroup.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Sanz-Vidal
authors.affiliation: Department of Chemistry, Imperial College London Exhibition Road South Kensington, London SW7 2AZ, UK , http://www3.imperial.ac.uk/diez-gonzalezgroup.
authors.forename: Eric
authors.initials: E
authors.lastname: Tan
authors.affiliation: Department of Chemistry, Imperial College London Exhibition Road South Kensington, London SW7 2AZ, UK , http://www3.imperial.ac.uk/diez-gonzalezgroup.
authors.forename: Shing-Hing
authors.initials: SH
authors.lastname: Lau
authors.affiliation: Department of Chemistry, University College London Christopher Ingold Laboratories 20 Gordon Street London WC1H 0AJ, UK.
authors.forename: Tom D
authors.initials: TD
authors.lastname: Sheppard
authors.affiliation: Department of Chemistry, Imperial College London Exhibition Road South Kensington, London SW7 2AZ, UK , http://www3.imperial.ac.uk/diez-gonzalezgroup.
authors.forename: Silvia
authors.initials: S
authors.lastname: Díez-González
keywords: Brønsted acid; Friedel–Crafts reaction; Homogeneous ­catalysis; Nucleophilic substitution; Propargylic alcohols