title: Rare Primary Adenocarcinoma of the Broad Ligament: Report of Two Cases and a Literature Review.
abstract: Malignant primary tumors arising in the uterine broad ligament are extremely rare, and only 26 cases have been reported to date. We describe 2 new cases of primary adenocarcinoma of the broad ligament, and we review the previous literature on such rare tumors. In Case 1, a 71-year-old woman presented with a 2-month history of increased yellow vaginal discharge and lower abdominal pain during bowel movement. Transvaginal sonography revealed a 6.5 cm mass located on the dorsum of the uterus and a 7.0 cm mass (with cystic and solid parts) near the right adnexa. We postoperatively diagnosed the mass as a high-grade serous carcinoma of the broad ligament (pT3cNXM0). The patient is currently receiving adjuvant chemotherapy with paclitaxel and carboplatin. In Case 2, during a complete medical checkup a 43-year-old woman was found to have a pelvic mass indicative of leiomyoma. Transvaginal sonography revealed a 3.8 cm mass located on the dorsum of the uterus. Following surgery, we diagnosed the mass as a clear cell adenocarcinoma of the broad ligament (pT2bN1M0). This patient is also now receiving adjuvant chemotherapy with paclitaxel and carboplatin.
authors.affiliation: Kaizuka City Hospital, Osaka, Japan aimiyoshi20090808@yahoo.co.jp.
authors.forename: Ai
authors.initials: A
authors.lastname: Miyoshi
authors.affiliation: Kaizuka City Hospital, Osaka, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyatake
authors.affiliation: Kaizuka City Hospital, Osaka, Japan.
authors.forename: Takeya
authors.initials: T
authors.lastname: Hara
authors.affiliation: Kaizuka City Hospital, Osaka, Japan.
authors.forename: Shinnosuke
authors.initials: S
authors.lastname: Komiya
authors.affiliation: Kaizuka City Hospital, Osaka, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Komura
authors.affiliation: Kaizuka City Hospital, Osaka, Japan.
authors.forename: Asuka
authors.initials: A
authors.lastname: Tanaka
authors.affiliation: Kaizuka City Hospital, Osaka, Japan.
authors.forename: Serika
authors.initials: S
authors.lastname: Kanao
authors.affiliation: Kaizuka City Hospital, Osaka, Japan.
authors.forename: Masumi
authors.initials: M
authors.lastname: Takeda
authors.affiliation: Kaizuka City Hospital, Osaka, Japan.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Mimura
authors.affiliation: Kaizuka City Hospital, Osaka, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nagamatsu
authors.affiliation: Kaizuka City Hospital, Osaka, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Yamasaki
authors.affiliation: Kaizuka City Hospital, Osaka, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yokoi
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology*; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001956:Broad Ligament / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry
chemical_list: D014408:Biomarkers, Tumor
keywords: broad ligament; clear cell adenocarcinoma; primary tumor