title: Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins.
abstract: The emergence of antibiotic resistance is currently considered one of the most important global health problem. The continuous onset of multidrug-resistant Gram-positive and Gram-negative bacterial strains limits the clinical efficacy of most of the marketed antibiotics. Therefore, there is an urgent need for new antibiotics. Pyrrolomycins are a class of biologically active compounds that exhibit a broad spectrum of biological activities, including antibacterial, antifungal, anthelmintic, antiproliferative, insecticidal, and acaricidal activities. In this review we focus on the antibacterial activity and antibiofilm activity of pyrrolomycins against Gram-positive and Gram-negative pathogens. Their efficacy, combined in some cases with a low toxicity, confers to these molecules a great potential for the development of new antimicrobial agents to face the antibiotic crisis.
authors.affiliation: Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche-Sezione di Chimica e Tecnologie Farmaceutiche-Università degli Studi di Palermo, Via Archirafi 32, Palermo 90123, Italy. stellamaria.cascioferro@unipa.it.|IEMEST, Istituto Euromediterraneo di Scienza e Tecnologia, Via Emerico Amari, 123, Palermo 90139, Italy. stellamaria.cascioferro@unipa.it.
authors.forename: Stella
authors.initials: S
authors.lastname: Cascioferro
authors.affiliation: Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche-Sezione di Chimica e Tecnologie Farmaceutiche-Università degli Studi di Palermo, Via Archirafi 32, Palermo 90123, Italy. mariavaleria.raimondi@unipa.it.
authors.forename: Maria Valeria
authors.initials: MV
authors.lastname: Raimondi
authors.affiliation: Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche-Sezione di Chimica e Tecnologie Farmaceutiche-Università degli Studi di Palermo, Via Archirafi 32, Palermo 90123, Italy. mariagrazia.cusimano@unipa.it.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Cusimano
authors.affiliation: Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche-Sezione di Chimica e Tecnologie Farmaceutiche-Università degli Studi di Palermo, Via Archirafi 32, Palermo 90123, Italy. demetrio.raffa@unipa.it.
authors.forename: Demetrio
authors.initials: D
authors.lastname: Raffa
authors.affiliation: Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche-Sezione di Chimica e Tecnologie Farmaceutiche-Università degli Studi di Palermo, Via Archirafi 32, Palermo 90123, Italy. benedetta.maggio@unipa.it.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Maggio
authors.affiliation: Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche-Sezione di Chimica e Tecnologie Farmaceutiche-Università degli Studi di Palermo, Via Archirafi 32, Palermo 90123, Italy. giuseppe.daidone@unipa.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Daidone
authors.affiliation: Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche-Sezione di Chimica e Tecnologie Farmaceutiche-Università degli Studi di Palermo, Via Archirafi 32, Palermo 90123, Italy. domenico.schillaci@unipa.it.
authors.forename: Domenico
authors.initials: D
authors.lastname: Schillaci
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D018441:Biofilms / Q000187:drug effects; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D011758:Pyrroles; C032959:pyrrolomycin A
keywords: antibiofilm agents; antibiotic resistance; pentabromopseudilin; pyoluteorin; pyrrolomycins