title: Influence of substituent position and cavity size of the regioisomers of monocarboxymethyl-α-, β-, and γ-cyclodextrins on the apparent stability constants of their complexes with both enantiomers of Tröger's base.
abstract: Enantiomers of Tröger's base were separated by capillary electrophoresis using 2(I) -O-, 3(I) -O-, and 6(I) -O-carboxymethyl-α-, β-, and γ-cyclodextrin and native α-, β-, and γ-cyclodextrin as chiral additives at 0-12 mmol/L for β-cyclodextrin and its derivatives and 0-50 mmol/L for α- and γ-cyclodextrins and their derivatives in a background electrolyte composed of sodium phosphate buffer at 20 mmol/L concentration and pH 2.5. Apparent stability constants of all cyclodextrin-Tröger's base complexes were calculated based on capillary electrophoresis data. The obtained results showed that the position of the carboxymethyl group as well as the cavity size of the individual cyclodextrin significantly influences the apparent stability constants of cyclodextrin-Tröger's base complexes.
authors.affiliation: Department of Analytical Chemistry, University of Chemistry and Technology, Prague, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Řezanka
authors.affiliation: Department of Analytical Chemistry, University of Chemistry and Technology, Prague, Czech Republic.
authors.forename: Klára
authors.initials: K
authors.lastname: Řezanková
authors.affiliation: Department of Analytical Chemistry, University of Chemistry and Technology, Prague, Czech Republic.
authors.forename: Helena
authors.initials: H
authors.lastname: Sedláčková
authors.affiliation: Department of Analytical Chemistry, University of Chemistry and Technology, Prague, Czech Republic.
authors.forename: Jindřich
authors.initials: J
authors.lastname: Mašek
authors.affiliation: Department of Analytical Chemistry, University of Chemistry and Technology, Prague, Czech Republic.
authors.forename: Lenka
authors.initials: L
authors.lastname: Rokosová
authors.affiliation: Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Prague 2, Czech Republic.
authors.forename: Markéta
authors.initials: M
authors.lastname: Bláhová
authors.affiliation: Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Liberec 1, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Řezanka
authors.affiliation: Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Prague 2, Czech Republic.
authors.forename: Jindřich
authors.initials: J
authors.lastname: Jindřich
authors.affiliation: Department of Analytical Chemistry, University of Chemistry and Technology, Prague, Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Sýkora
authors.affiliation: Department of Analytical Chemistry, University of Chemistry and Technology, Prague, Czech Republic.
authors.forename: Vladimír
authors.initials: V
authors.lastname: Král
keywords: Capillary electrophoresis; Chiral separation; Cyclodextrin; Regioisomers; Stability constants