title: Increased Risk for ESBL-Producing Bacteria from Co-administration of Loperamide and Antimicrobial Drugs for Travelers' Diarrhea.
abstract: Antimicrobial drug treatment of travelers' diarrhea is known to increase the risk for colonization with extended-spectrum β-lactamase-producing Enterobacteriaceae. Among 288 travelers with travelers' diarrhea, the colonization rate without medications was 21%. For treatment with loperamide only, the rate was 20%; with antimicrobial drugs alone, 40%; and with loperamide and antimicrobial drugs, 71%.
authors.forename: Anu
authors.initials: A
authors.lastname: Kantele
authors.forename: Sointu
authors.initials: S
authors.lastname: Mero
authors.forename: Juha
authors.initials: J
authors.lastname: Kirveskari
authors.forename: Tinja
authors.initials: T
authors.lastname: Lääveri
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D003967:Diarrhea / Q000188:drug therapy* / Q000382:microbiology*; D004755:Enterobacteriaceae / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D008139:Loperamide / Q000008:administration & dosage* / Q000009:adverse effects*; D008297:Male; D012306:Risk; D014195:Travel; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D008139:Loperamide; D001618:beta-Lactamases
keywords: AMD; ESBL; antibiotic resistance; antibiotics; antidiarrheal; antimicrobial drugs; antimicrobial resistance; diarrhea; extended-spectrum beta-lactamase–producing Enterobacteriaceae; loperamide; travel; travel health; travel medicine; travelers’ diarrhea