title: Sperm Centrosomes: Kiss Your Asterless Goodbye, for Fertility's Sake.
abstract: Centrosomes are reduced to their cores in sperm. Emerging molecular explanations for centrosome construction have now helped to elucidate the mechanism of their destruction in sperm. Since centrosome inaccuracies cause aneuploidies responsible for cancers, birth defects and infertility, this new insight into centrosome behavior has broad implications.
authors.affiliation: Departments of Ob-Gyn-Repro Sci, Cell Biology & Bioengineering, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address: gschatten@pdc.magee.edu.
authors.forename: Gerald
authors.initials: G
authors.lastname: Schatten
authors.affiliation: Departments of Biology & Genetics, Stanford University, Stanford, CA 94305, USA. Electronic address: stearns@stanford.edu.
authors.forename: Tim
authors.initials: T
authors.lastname: Stearns
mesh_terms: D018385:Centrosome; D005298:Fertility; D005306:Fertilization; D006801:Humans; D007246:Infertility; D013094:Spermatozoa