title: Date (Phoenix dactylifera) Polyphenolics and Other Bioactive Compounds: A Traditional Islamic Remedy's Potential in Prevention of Cell Damage, Cancer Therapeutics and Beyond.
abstract: This review analyzes current studies of the therapeutic effects of Phoenix dactylifera, or date palm fruit, on the physiologic system. Specifically, we sought to summarize the effects of its application in preventing cell damage, improving cancer therapeutics and reducing damage caused by conventional chemotherapy. Phoenix dactylifera exhibits potent anti-oxidative properties both in vitro and in vivo. This allows the fruit to prevent depletion of intrinsic protection from oxidative cell damage and assist these defense systems in reducing cell damage. Macroscopically, this mechanism may be relevant to the prevention of various adverse drug events common to chemotherapy including hepatotoxicity, nephrotoxicity, gastrotoxicity, and peripheral neuropathy. While such effects have only been studied in small animal systems, research suggests a potential application to more complex mammalian systems and perhaps a solution to some problems of chemotherapy in hepato-compromised and nephro-compromised patients.
authors.affiliation: The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA. bibi.yasin@alumni.acphs.edu.
authors.forename: Bibi R
authors.initials: BR
authors.lastname: Yasin
authors.affiliation: Neurotoxicology Laboratory, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, USA. hassan.el-fawal@acphs.edu.
authors.forename: Hassan A N
authors.initials: HA
authors.lastname: El-Fawal
authors.affiliation: The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA. shaker.mousa@acphs.edu.
authors.forename: Shaker A
authors.initials: SA
authors.lastname: Mousa
mesh_terms: D000818:Animals; D019610:Cytoprotection / Q000187:drug effects*; D006801:Humans; D007514:Islam; D008519:Medicine, Traditional; D009369:Neoplasms / Q000188:drug therapy*; D018384:Oxidative Stress / Q000187:drug effects*; D065749:Phoeniceae / Q000737:chemistry*; D059808:Polyphenols / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D059808:Polyphenols
keywords: chemotherapy-induced adverse events; hepatotoxicity; mucositis; nephrotoxicity; peripheral neuropathy