title: Effects of Short-Term Exenatide Treatment on Regional Fat Distribution, Glycated Hemoglobin Levels, and Aortic Pulse Wave Velocity of Obese Type 2 Diabetes Mellitus Patients.
abstract: BACKGROUND
  Most type 2 diabetes mellitus patients are obese and have obesity related vascular complications. Exenatide treatment is well known for both decreasing glycated hemoglobin levels and reduction in body weight. So, this study aimed to determine the effects of exenatide on body composition, glycated hemoglobin levels, and vascular stiffness in obese type 2 diabetes mellitus patients.
  
  
  METHODS
  For 1 month, 32 obese type 2 diabetes mellitus patients were administered 5 μg of exenatide twice daily. The dosage was then increased to 10 μg. Patients' height, body weight, glycated hemoglobin levels, lipid profile, pulse wave velocity (PWV), body mass index, fat mass, and muscle mass were measured by using Inbody at baseline and after 3 months of treatment.
  
  
  RESULTS
  After 3 months of treatment, glycated hemoglobin levels decreased significantly (P=0.007). Triglyceride, total cholesterol, and low density lipoprotein levels decreased, while aspartate aminotransferase and alanine aminotransferase levels were no change. Body weight, and fat mass decreased significantly (P=0.002 and P=0.001, respectively), while interestingly, muscle mass did not decrease (P=0.289). In addition to, Waist-to-hip ratio and aortic PWV decreased significantly (P=0.006 and P=0.001, respectively).
  
  
  CONCLUSIONS
  Effects of short term exenatide use in obese type 2 diabetes mellitus with cardiometabolic high risk patients not only reduced body weight without muscle mass loss, body fat mass, and glycated hemoglobin levels but also improved aortic PWV in accordance with waist to hip ratio.
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Ju Young
authors.identifier: http://orcid.org/0000-0001-8876-9890
authors.initials: JY
authors.lastname: Hong
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Keun Young
authors.initials: KY
authors.lastname: Park
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
authors.forename: Byung Joon
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Won Min
authors.initials: WM
authors.lastname: Hwang
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Dong Ho
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea. mdldm@hanmail.net.
authors.forename: Dong Mee
authors.identifier: http://orcid.org/0000-0001-9073-0872
authors.initials: DM
authors.lastname: Lim
keywords: Body composition; Exenatide; Pulse wave analysis