title: New Alcamide and Anti-oxidant Activity of Pilosocereus gounellei A. Weber ex K. Schum. Bly. ex Rowl. (Cactaceae).
abstract: The Cactaceae family is composed by 124 genera and about 1438 species. Pilosocereus gounellei, popularly known in Brazil as xique-xique, is used in folk medicine to treat prostate inflammation, gastrointestinal and urinary diseases. The pioneering phytochemical study of P. gounellei was performed using column chromatography and HPLC, resulting in the isolation of 10 substances: pinostrobin (1), β-sitosterol (2), a mixture of sitosterol 3-O-β-d-glucopyranoside/stigmasterol 3-O-β-d-glucopyranoside (3a/3b), 13²-hydroxyphaeophytin a (4), phaeophytin a (5), a mixture of β-sitosterol and stigmasterol (6a/6b), kaempferol (7), quercetin (8), 7'-ethoxy-trans-feruloyltyramine (mariannein, 9) and trans-feruloyl tyramine (10). Compound 9 is reported for the first time in the literature. The structural characterization of the compounds was performed by analyses of 1-D and 2-D NMR data. In addition, a phenolic and flavonol total content assay was carried out, and the anti-oxidant potential of P. gounellei was demonstrated.
authors.affiliation: Post-Graduation Program in Development and Technological Innovation in Medicines, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900, Brazil. jksmaciel@hotmail.com.
authors.forename: Jéssica K S
authors.initials: JK
authors.lastname: Maciel
authors.affiliation: Post-Graduation Program in Bioactive Natural and Synthetic Products, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900 Brazil. otemberg_sc@yahoo.com.br.
authors.forename: Otemberg S
authors.initials: OS
authors.lastname: Chaves
authors.affiliation: Post-Graduation Program in Bioactive Natural and Synthetic Products, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900 Brazil. severinogfilho@yahoo.com.br.
authors.forename: Severino G
authors.initials: SG
authors.lastname: Brito Filho
authors.affiliation: Post-Graduation Program in Development and Technological Innovation in Medicines, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900, Brazil. yannateles@gmail.com.
authors.forename: Yanna C F
authors.initials: YC
authors.lastname: Teles
authors.affiliation: Post-Graduation Program in Bioactive Natural and Synthetic Products, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900 Brazil. marianne.guedes@gmail.com.
authors.forename: Marianne G
authors.initials: MG
authors.lastname: Fernandes
authors.affiliation: Post-Graduation Program in Development and Technological Innovation in Medicines, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900, Brazil. temilce@gmail.com.|Health Science Centre, Physiology and Pathology Department, Federal University of Paraiba, Campus I, Cidade Universitária-João Pessoa, PB, 58059-900, Brazil. temilce@gmail.com.
authors.forename: Temilce S
authors.initials: TS
authors.lastname: Assis
authors.affiliation: Department of Agroecology and Agriculture, Center of Agricultural and Environmental Sciences, University of Paraiba State, 351 Baraúnas Street, Campina Grande, PB, 58429-500, Brazil. pedrodantasfernandes@gmail.com.
authors.forename: Pedro Dantas
authors.initials: PD
authors.lastname: Fernandes
authors.affiliation: Department of Agroecology and Agriculture, Center of Agricultural and Environmental Sciences, University of Paraiba State, 351 Baraúnas Street, Campina Grande, PB, 58429-500, Brazil. albericio3@gmail.com.
authors.forename: Alberício Pereira
authors.initials: AP
authors.lastname: de Andrade
authors.affiliation: Department of Agroecology and Agriculture, Center of Agricultural and Environmental Sciences, University of Paraiba State, 351 Baraúnas Street, Campina Grande, PB, 58429-500, Brazil. lpfelix@hotmail.com.
authors.forename: Leonardo P
authors.initials: LP
authors.lastname: Felix
authors.affiliation: Postgraduate Program in Development and Technological Innovation in Medicines, Department of Molecular Sciences, Rural Federal University of Pernambuco, Campus Dois Irmãos, Recife, PE, 52171-900, Brazil. sarmentosilva@gmail.com.
authors.forename: Tania M S
authors.initials: TM
authors.lastname: Silva
authors.affiliation: Postgraduate Program in Development and Technological Innovation in Medicines, Department of Molecular Sciences, Rural Federal University of Pernambuco, Campus Dois Irmãos, Recife, PE, 52171-900, Brazil. quinathi@gmail.com.
authors.forename: Nathalia S M
authors.initials: NS
authors.lastname: Ramos
authors.affiliation: Postgraduate Program in Development and Technological Innovation in Medicines, Department of Molecular Sciences, Rural Federal University of Pernambuco, Campus Dois Irmãos, Recife, PE, 52171-900, Brazil. girlianeregina@gmail.com.
authors.forename: Girliane R
authors.initials: GR
authors.lastname: Silva
authors.affiliation: Post-Graduation Program in Development and Technological Innovation in Medicines, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900, Brazil. mfvanderlei@ltf.ufpb.br.|Post-Graduation Program in Bioactive Natural and Synthetic Products, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900 Brazil. mfvanderlei@ltf.ufpb.br.
authors.forename: Maria de Fátima Vanderlei
authors.initials: Mde F
authors.lastname: de Souza
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D029421:Cactaceae / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003373:Coumaric Acids / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D008519:Medicine, Traditional; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D014439:Tyramine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D003373:Coumaric Acids; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; C074004:feruloyltyramine; D014439:Tyramine
keywords: 7′-ethoxy-trans-feruloyltyramine; Pilosocereus gounellei; anti-oxidant activity