title: Elevation of serum interleukins 8, 4, and 1β levels in patients with gastrointestinal low-grade B-cell lymphoma.
abstract: Proinflammatory cytokines that are produced by helper T cells (Th) regulate immune reactions, facilitate class switching of B cells, and prolong the lifespan of B and T cells. Eradication therapy using antibiotics is sometimes effective against gastrointestinal (GI) malignant lymphoma, suggesting that the tumor development or progression is affected by the inflammatory microenvironment. In the present study, serum samples from 148 patients with various subtypes of malignant lymphoma were tested for 11 proinflammatory Th1/Th2 cytokines. In the comparison by subtype or GI lesions, serum interleukin (IL)-8 (P = 6.7E-05), IL-4 (P = 7.5E-05), and IL-1β (P = 0.0043) levels showed significant differences among subtypes, being particularly elevated in follicular lymphomas (FL) and mucosa-associated lymphoid tissue (MALT) lymphomas. Serum IL-8 levels were elevated in GI-FL and MALT lymphomas, and serum IL-4 and IL-1 β levels were elevated in MALT lymphomas. These findings show that GI low-grade B-cell lymphoma could develop against the background of an inflammatory microenvironment. Thus, these cytokines may be useful as diagnostic markers and could provide new insights into tumor development.
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Miyata-Takata
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Takata
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.|Department of Pathology, Okayama Medical Center, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Toji
authors.affiliation: Department of Hematology, Gihoku Kosei Hospital, Japan.
authors.forename: Naoe
authors.initials: N
authors.lastname: Goto
authors.affiliation: Department of Hematology, Gifu City Hospital, Japan.
authors.forename: Senji
authors.initials: S
authors.lastname: Kasahara
authors.affiliation: Department of Hematology, Gifu City Hospital, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Department of Gastroenterology, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Tari
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Noujima-Harada
authors.affiliation: Department of Computer Science and Engineering, Fukuoka Institute of Technology, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Miyata
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor; C508606:CXCL8 protein, human; D018836:Inflammation Mediators; D053583:Interleukin-1beta; D016209:Interleukin-8; D015847:Interleukin-4