title: Development of a cell permeable red-shifted CHEF-based chemosensor for Al(3+) ion by controlling PET.
abstract: A structurally modified quinazoline derivative (L) acts as highly selective chemosensor for Al(3+) ions in DMSO-H2O (1:9, v/v) over the other competitive metal ions. L shows a red shifted fluorescence after the addition of Al(3+) ions and later the further fluorescence enhancement is due to chelation enhanced fluorescence (CHEF) through inhibition of photoinduced electron transfer (PET). This probe (L) detects Al(3+) ions as low as 9nM in DMSO-H2O (1:9, v/v) at biological pH. The non-cytotoxic probe (L) can efficiently detect the intercellular distribution of Al(3+) ions in living cells under a fluorescence microscope to exhibit its sensible applications in the biological systems.
authors.affiliation: Department of Chemistry, Burdwan University, Golapbag, Burdwan 713104, West Bengal, India.
authors.forename: Manjira
authors.initials: M
authors.lastname: Mukherjee
authors.affiliation: Department of Chemistry, Burdwan University, Golapbag, Burdwan 713104, West Bengal, India.
authors.forename: Buddhadeb
authors.initials: B
authors.lastname: Sen
authors.affiliation: Department of Chemistry, Burdwan University, Golapbag, Burdwan 713104, West Bengal, India.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Pal
authors.affiliation: Department of Chemistry, Burdwan University, Golapbag, Burdwan 713104, West Bengal, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Maji
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, West Bengal 741252, India.
authors.forename: Darshita
authors.initials: D
authors.lastname: Budhadev
authors.affiliation: Department of Chemistry, Burdwan University, Golapbag, Burdwan 713104, West Bengal, India. Electronic address: pabitracc@yahoo.com.
authors.forename: Pabitra
authors.initials: P
authors.lastname: Chattopadhyay
mesh_terms: D000535:Aluminum / Q000032:analysis*; D002412:Cations / Q000032:analysis; D002460:Cell Line; D002614:Chelating Agents / Q000737:chemistry*; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D004579:Electron Transport; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D008856:Microscopy, Fluorescence; D010539:Permeability; D055668:Photochemical Processes; D011799:Quinazolines / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry
chemical_list: D002412:Cations; D002614:Chelating Agents; D005456:Fluorescent Dyes; D011799:Quinazolines; D014867:Water; D000535:Aluminum; D004121:Dimethyl Sulfoxide
keywords: Aluminium(III); CHEF; Chemosensor; PET control; Red shift