title: CD8 T-Cell Lymphocytosis and Associated Clinical Syndromes in HIV-Infected Patients.
abstract: An inverted CD4:CD8 T lymphocyte ratio is frequently observed in individuals infected with HIV. A subset of these individuals develops an exuberant and persistent CD8 T-cell lymphocytosis response to HIV infection that may occur despite virologic suppression on treatment and has been associated with adverse clinical effects and disorders. This review describes clinical syndromes that have been reported primarily in HIV-infected individuals with CD8 T-cell lymphocytosis including their presentation, management, and clinical outcomes where known.
authors.affiliation: Yale-New Haven Hospital, New Haven, Connecticut, USA.
authors.forename: Perry J
authors.initials: PJ
authors.lastname: Tiberio
authors.affiliation: Yale AIDS Program, Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Onyema E
authors.initials: OE
authors.lastname: Ogbuagu
mesh_terms: D016516:CD4-CD8 Ratio; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018450:Disease Progression; D015658:HIV Infections / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D008218:Lymphocytosis / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D011379:Prognosis; D016201:Receptors, Lymphocyte Homing / Q000276:immunology*; D013577:Syndrome; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D016201:Receptors, Lymphocyte Homing