title: The Function and Roles of ADAMTS-7 in Inflammatory Diseases.
abstract: The ADAMTS proteinases are a group of multidomain and secreted metalloproteinases containing the thrombospondin motifs. ADAMTS-7 is a member of ADAMTS family and plays a crucial role in the pathogenesis of arthritis. Overexpression of ADAMTS-7 gene promotes the breakdown of cartilage oligomeric matrix protein (COMP) matrix and accelerates the progression of both surgically induced osteoarthritis and collagen-induced arthritis. Moreover, ADAMTS-7 and tumor necrosis factor-α (TNF-α) form a positive feedback loop in osteoarthritis. More significantly, granulin-epithelin precursor, a growth factor has important roles in bone development and bone-associated diseases, disturbs the interaction between ADAMTS-7 and COMP, and prevents COMP degradation. This review is based on our results and provides an overview of current knowledge of ADAMTS-7, including its structure, function, gene regulation, and inflammatory diseases involvement.
authors.affiliation: School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Jiqiang
authors.initials: J
authors.lastname: Lin
authors.affiliation: College of Agriculture, Ningxia University, Yinchuan 750021, China.
authors.forename: Fanhua
authors.initials: F
authors.lastname: Wei
mesh_terms: D051722:ADAM Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D000071096:ADAMTS Proteins; D000071118:ADAMTS7 Protein; D001168:Arthritis / Q000209:etiology; D050197:Atherosclerosis / Q000209:etiology; D002394:Catechol O-Methyltransferase / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000209:etiology*
chemical_list: C588010:COMT protein, human; D002394:Catechol O-Methyltransferase; D051722:ADAM Proteins; D000071096:ADAMTS Proteins; C496252:ADAMTS12 protein, human; D000071118:ADAMTS7 Protein; C121534:ADAMTS7 protein, human