title: Multi-omic profiling of MYCN-amplified neuroblastoma cell-lines.
abstract: Neuroblastoma is the most common pediatric cancer, arising from the neural crest cells of the sympathetic nervous system. Its most aggressive subtype, characterized by the amplification of the MYCN oncogene, has a dismal prognosis and no effective treatment is available. Understanding the alterations induced by the tumor on the various layers of gene expression is therefore important for a complete characterization of this neuroblastoma subtype and for the discovery of new therapeutic opportunities. Here we describe the profiling of 13 MYCN-amplified neuroblastoma cell lines at the genome (copy number), transcriptome, translatome and miRome levels (GEO series GSE56654, GSE56552 and GSE56655). We provide detailed experimental and data analysis procedures by means of which we derived the results described in [1].
authors.affiliation: Laboratory of Translational Genomics, Centre for Integrative Biology, University of Trento, Italy.
authors.forename: Erik
authors.initials: E
authors.lastname: Dassi
authors.affiliation: Laboratory of Translational Genomics, Centre for Integrative Biology, University of Trento, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Greco
authors.affiliation: Laboratory of Translational Genomics, Centre for Integrative Biology, University of Trento, Italy.
authors.forename: Viktoryia
authors.initials: V
authors.lastname: Sidarovich
authors.affiliation: Laboratory of Translational Genomics, Centre for Integrative Biology, University of Trento, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Zuccotti
authors.affiliation: Laboratory of Translational Genomics, Centre for Integrative Biology, University of Trento, Italy.
authors.forename: Natalia
authors.initials: N
authors.lastname: Arseni
authors.affiliation: Center of Physiopathology of Human Reproduction, Unit of Obstetrics and Gynecology, IRCCS A.O.U. San Martino IST, Genoa, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Scaruffi
authors.affiliation: Neuroblastoma Laboratory, Pediatric Research Institute, Fondazione Città della Speranza, Padua, Italy.
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Tonini
authors.affiliation: Laboratory of Translational Genomics, Centre for Integrative Biology, University of Trento, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Quattrone
keywords: Copy-number; MiRome; Neuroblastoma; Transcriptome; Translatome