title: Galectin-3 Predicts Left Ventricular Remodeling of Hypertension.
abstract: Previous studies have suggested that galectin-3 is an important mediator of cardiac fibrosis. The aim of this study was to investigate the utility of galectin-3 in identifying early left ventricular remodeling (LVRM) in patients with hypertension. A total of 107 patients with hypertension and 108 controls were enrolled in this study. The levels of galectin-3 were significantly greater in hypertension patients with LVRM compared with those without LVRM. Multivariate regression analysis demonstrated that body mass index and galectin-3 were independent predictors of LVRM in the hypertension group. Only left ventricular mass was independently correlated with serum galectin-3 levels in patients with hypertension. The receiver operating characteristic analysis showed an area under the curve for galectin-3 of 0.698 (P<.001), with an optimal cutoff of 9.43 ng/mL. Therefore, galectin-3 is independently correlated with LVRM and can be regarded as a valuable biomarker of early cardiac remodeling of hypertension.
authors.affiliation: Division of Cardiology, Department of Medicine, The Affiliated People's Hospital of Jiangsu University, ZhenJiang City, Jiangsu Province, China.
authors.forename: Yongwei
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Division of Cardiology, Department of Medicine, The Affiliated People's Hospital of Jiangsu University, ZhenJiang City, Jiangsu Province, China.
authors.forename: Dongli
authors.initials: D
authors.lastname: Shen
authors.affiliation: Division of Cardiology, Department of Medicine, The Affiliated People's Hospital of Jiangsu University, ZhenJiang City, Jiangsu Province, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Chen
authors.affiliation: Division of Cardiology, Department of Medicine, The Affiliated People's Hospital of Jiangsu University, ZhenJiang City, Jiangsu Province, China.
authors.forename: Chunyang
authors.initials: C
authors.lastname: Ying
authors.affiliation: Division of Cardiology, Department of Medicine, The Affiliated People's Hospital of Jiangsu University, ZhenJiang City, Jiangsu Province, China.
authors.forename: Chenghua
authors.initials: C
authors.lastname: Wang
authors.affiliation: Division of Cardiology, Department of Medicine, The Affiliated People's Hospital of Jiangsu University, ZhenJiang City, Jiangsu Province, China.
authors.forename: Junfang
authors.initials: J
authors.lastname: Guo
authors.affiliation: Division of Cardiology, Department of Medicine, The Affiliated People's Hospital of Jiangsu University, ZhenJiang City, Jiangsu Province, China.
authors.forename: Guohui
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000368:Aged; D001798:Blood Proteins; D005260:Female; D037502:Galectin 3 / Q000097:blood*; D037161:Galectins; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D015854:Up-Regulation; D018487:Ventricular Dysfunction, Left / Q000473:pathology; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D001798:Blood Proteins; D037502:Galectin 3; D037161:Galectins; C428445:LGALS3 protein, human