title: Sinonasal mucosal melanoma: A 12-year experience of 58 cases.
abstract: Sinonasal mucosal melanoma is a rare malignancy with poor prognosis.
  
  
  
  Patients with sinonasal malignant melanoma who underwent surgery by different approaches were included in this study. Overall survival (OS) and event-free survival were calculated, and statistically significant variables by univariate analysis were entered in a multivariate Cox regression model.
  
  
  
  Pathological staging was pT3, pT4a, and pT4b in 30 cases (51.7%), 17 cases (29.3%), and 11 cases (19.0%). At 3 and 5 years, OS was 43.5% and 29% and event-free survival was 23.6% and 12.4%, respectively. At univariate analysis, OS was significantly influenced by male sex, advanced pT classification, positive margins, and surgical approach; event-free survival was affected by positive margins. At multivariate analysis, the risk of death was independently associated with male sex (hazard ratio [HR] = 2.27; p = .04) and positive margins (HR = 2.32; p = .03).
  
  
  
  Male sex and positive margins were negative prognostic factors. Endoscopic resection did not show an increased risk of death compared with more extensive surgical approaches. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1737-E1745, 2016.
authors.affiliation: Department of Otorhinolaryngology, University of Brescia, Brescia, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Lombardi
authors.affiliation: Department of Otorhinolaryngology, University of Brescia, Brescia, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Bottazzoli
authors.affiliation: Department of Otorhinolaryngology, University of Insubria, Varese, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Turri-Zanoni
authors.affiliation: Unit of Hygiene, Epidemiology and Public Health, University of Brescia, Brescia, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Raffetti
authors.affiliation: Department of Otorhinolaryngology, University of Brescia, Brescia, Italy.
authors.forename: Andrea Bolzoni
authors.initials: AB
authors.lastname: Villaret
authors.affiliation: Department of Pathology, University of Brescia, Brescia, Italy.
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Morassi
authors.affiliation: Department of Pathology, University of Brescia, Brescia, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Ungari
authors.affiliation: Department of Molecular and Translational Medicine, Section of Pathology, University of Brescia, Brescia, Italy.
authors.forename: William
authors.initials: W
authors.lastname: Vermi
authors.affiliation: Department of Otorhinolaryngology, University of Insubria, Varese, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Battaglia
authors.affiliation: Department of Otorhinolaryngology, University of Insubria, Varese, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Castelnuovo
authors.affiliation: Department of Pathology, University of Insubria, Varese, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Facco
authors.affiliation: Department of Pathology, University of Insubria, Varese, Italy.
authors.forename: Fausto
authors.initials: F
authors.lastname: Sessa
authors.affiliation: Unit of Hygiene, Epidemiology and Public Health, University of Brescia, Brescia, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Donato
authors.affiliation: Department of Otorhinolaryngology, University of Brescia, Brescia, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Nicolai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000628:therapy; D008875:Middle Aged; D009297:Nasal Mucosa / Q000473:pathology*; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000628:therapy; D010256:Paranasal Sinuses / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
keywords: endoscopic surgery; mucosal melanoma; prognosis; sinonasal tract; survival