title: A 7-year study of the distribution of nosocomial candidemia in children with cancer.
abstract: Candidemia is an important cause of morbidity and mortality in cancer patients. The incidence of candidemia has been reported to have shifted toward nonalbicans species. The aim of this study was to determine the distribution of Candida species resulting in bloodstream infections or catheter-related blood stream infections (CRBSIs) in pediatric hematology-oncology (PHO) patients over a 7-year-period. Medical and computerized microbiology laboratory records of all positive blood fungal cultures during the study period were analyzed retrospectively. The ratio of non-albicans Candida species (81.4%) was nearly four times higher than that of C. albicans candidemia (18.5%). Overall, C. parapsilosis caused the majority (61.4%) of candidemia episodes, followed by C. tropicalis (14.8%), C. famata (2.9%), C. ciferrii (1.4%) and C. glabrata (0.7%). The rate of CRBSIs was significantly higher in C. Parapsilosis candidemia. The overall rate of 30-day mortality in 135 candidemia episodes was 4.44%. Nearly half of the C. parapsilosis candidemia was associated with CRBSIs, suggesting its importance in PHO, in which several types of central venous catheters have been used.
authors.affiliation: Division of Pediatric Infectious Diseases Dr. Behçet Uz Children's Hospital, İzmir, Turkey. ilkerdevrim2003@yahoo.com.
authors.forename: İlker
authors.initials: İ
authors.lastname: Devrim
authors.forename: Bengü
authors.initials: B
authors.lastname: Demirağ
authors.forename: Yöntem
authors.initials: Y
authors.lastname: Yaman
authors.forename: Nuri
authors.initials: N
authors.lastname: Bayram
authors.forename: Fatih
authors.initials: F
authors.lastname: Özdemir
authors.forename: Ahu
authors.initials: A
authors.lastname: Kara
authors.forename: Gülcihan
authors.initials: G
authors.lastname: Özek
authors.forename: Yüce
authors.initials: Y
authors.lastname: Ayhan
authors.forename: Gamze
authors.initials: G
authors.lastname: Gülfidan
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Oymak
authors.forename: Canan
authors.initials: C
authors.lastname: Vergin
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use; D058387:Candidemia / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000382:microbiology* / Q000401:mortality; D012189:Retrospective Studies
chemical_list: D000935:Antifungal Agents