title: Vibrational mapping of sinonasal lesions by Fourier transform infrared imaging spectroscopy.
abstract: Fourier transform infrared imaging (FTIRI) is a powerful tool for analyzing biochemical changes in tumoral tissues. The head and neck region is characterized by a great variety of lesions, with different degrees of malignancy, which are often difficult to diagnose. Schneiderian papillomas are sinonasal benign neoplasms arising from the Schneiderian mucosa; they can evolve into malignant tumoral lesions (squamous cell carcinoma). In addition, they can sometimes be confused with the more common inflammatory polyps. Therefore, an early and definitive diagnosis of this pathology is mandatory. Progressing in our research on the study of oral cavity lesions, 15 sections consisting of inflammatory sinonasal polyps, benign Schneiderian papillomas, and sinonasal undifferentiated carcinomas were analyzed using FTIRI. To allow a rigorous description of these pathologies and to gain objective diagnosis, the epithelial layer and the adjacent connective tissue of each section were separately investigated by following a multivariate analysis approach. According to the nature of the lesion, interesting modifications were detected in the average spectra of the different tissue components, above all in the lipid and protein patterns. Specific band-area ratios acting as spectral markers of the different pathologies were also highlighted.
authors.affiliation: Università Politecnica delle Marche, Dipartimento di Scienze della Vita e dell'Ambiente, Via Brecce Bianche, 60131 Ancona, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Giorgini
authors.affiliation: Università Politecnica delle Marche, Dipartimento di Scienze e Ingegneria della Materia, dell'Ambiente ed Urbanistica, Via Brecce Bianche, 60131 Ancona, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Sabbatini
authors.affiliation: Università Politecnica delle Marche, Dipartimento di Scienze e Ingegneria della Materia, dell'Ambiente ed Urbanistica, Via Brecce Bianche, 60131 Ancona, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Conti
authors.affiliation: Università Politecnica delle Marche, Dipartimento di Scienze Biomediche e Sanità Pubblica, Via Conca, 71, 60126 Torrette (Ancona), Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Rubini
authors.affiliation: Università Politecnica delle Marche, Dipartimento di Scienze della Vita e dell'Ambiente, Via Brecce Bianche, 60131 Ancona, ItalycUniversità Politecnica delle Marche, Dipartimento di Scienze Biomediche e Sanità Pubblica, Via Conca, 71, 60126 Torrette (Anco.
authors.forename: Romina
authors.initials: R
authors.lastname: Rocchetti
authors.affiliation: Università Politecnica delle Marche, Dipartimento di Malattie Immuno-Allergiche e Respiratorie, Via Conca, 71, 60126 Torrette (Ancona), Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Re
authors.affiliation: Elettra-Sincrotrone Trieste, S.S. 14, Km 163.5, 34012 Basovizza (Trieste), Italy.
authors.forename: Lisa
authors.initials: L
authors.lastname: Vaccari
authors.affiliation: Elettra-Sincrotrone Trieste, S.S. 14, Km 163.5, 34012 Basovizza (Trieste), Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Mitri
authors.affiliation: Università degli Studi di Catania, Dipartimento di Scienze Chimiche, Via Andrea Doria, 6, 580138 Catania, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Librando
mesh_terms: D002277:Carcinoma / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003238:Connective Tissue / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005583:Fourier Analysis; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D007249:Inflammation; D008055:Lipids / Q000737:chemistry; D008444:Maxillary Sinus Neoplasms / Q000473:pathology*; D015999:Multivariate Analysis; D010212:Papilloma / Q000473:pathology*; D010255:Paranasal Sinus Neoplasms / Q000473:pathology*; D025341:Principal Component Analysis; D020545:Respiratory Mucosa / Q000473:pathology; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D008055:Lipids