title: Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl.
abstract: An easy and efficient procedure for the synthesis of 4-indolylquinoline derivatives is described. This process involves two steps, the first of which is the Michael addition of indole to nitrochalcones promoted by sulfamic acid under solvent free conditions and the second step is a reductive cyclization of the indolylnitrochalcone intermediates to 4-indolylquinoline derivatives by Fe/HCl in ethanol. In both steps, the reactions are clean and the yields of products are high.
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan. wcchen@taigenbiotech.com.
authors.forename: Wen-Chang
authors.initials: WC
authors.lastname: Chen
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan. ntnu21236@gmail.com.
authors.forename: Chan-Chieh
authors.initials: CC
authors.lastname: Lin
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan. kavalaveeru@gmail.com.
authors.forename: Veerababurao
authors.initials: V
authors.lastname: Kavala
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan. cwkuo.water@gmail.com.
authors.forename: Chun-Wei
authors.initials: CW
authors.lastname: Kuo
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan. tlotras@gmail.com.
authors.forename: Chia-Yu
authors.initials: CY
authors.lastname: Huang
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan. cheyaocf@ntnu.edu.tw.
authors.forename: Ching-Fa
authors.initials: CF
authors.lastname: Yao
mesh_terms: D047188:Chalcones / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D003500:Cyclization; D005290:Ferric Compounds / Q000737:chemistry*; D006851:Hydrochloric Acid / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D011804:Quinolines / Q000138:chemical synthesis*; D013451:Sulfonic Acids / Q000737:chemistry
chemical_list: D047188:Chalcones; D002712:Chlorides; D005290:Ferric Compounds; D007211:Indoles; D011804:Quinolines; D013451:Sulfonic Acids; C005741:sulfamic acid; D006851:Hydrochloric Acid; C024555:ferric chloride
keywords: 4-indolylquinoline; Fe/HCl; indolylchalcone; reductive cyclization