title: Transition-Metal-Free Deacylative Cleavage of Unstrained C(sp(3))-C(sp(2)) Bonds: Cyanide-Free Access to Aryl and Aliphatic Nitriles from Ketones and Aldehydes.
abstract: A transition-metal-free deacylative C(sp(3))-C(sp(2)) bond cleavage for the synthetically practical oxidative amination of ketones and aldehydes to nitriles is first described, using cheap and commercially abundant NaNO2 as the oxidant and the nitrogen source. Various nitriles bearing aryl, heteroaryl, alkyl, and alkenyl groups could be smoothly obtained from ketones and aldehydes in high yields, avoiding highly toxic cyanides or transition metals.
authors.affiliation: Center of Advanced Nanocatalysis, Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, China.
authors.forename: Jing-Jie
authors.initials: JJ
authors.lastname: Ge
authors.affiliation: Center of Advanced Nanocatalysis, Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, China.
authors.forename: Chuan-Zhi
authors.initials: CZ
authors.lastname: Yao
authors.affiliation: Center of Advanced Nanocatalysis, Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, China.
authors.forename: Mei-Mei
authors.initials: MM
authors.lastname: Wang
authors.affiliation: Center of Advanced Nanocatalysis, Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, China.
authors.forename: Hong-Xing
authors.initials: HX
authors.lastname: Zheng
authors.affiliation: Center of Advanced Nanocatalysis, Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, China.
authors.forename: Yan-Biao
authors.initials: YB
authors.lastname: Kang
authors.affiliation: Center of Advanced Nanocatalysis, Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, China.|Department of Chemistry, Collaborative Innovation Center for Nanomaterial Science and Engineering, Tsinghua University , Beijing 100084, China.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Li