title: Early Activation of Primary Brain Microvascular Endothelial Cells by Nipah Virus Glycoprotein-Containing Particles.
abstract: Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes pronounced infection of brain endothelia and central nervous system (CNS) inflammation. Using primary porcine brain microvascular endothelial cells, we showed that upregulation of E-selectin precedes cytokine induction and is induced not only by infectious NiV but also by NiV-glycoprotein-containing virus-like particles. This demonstrates that very early events in NiV brain endothelial infection do not depend on NiV replication but can be triggered by the NiV glycoproteins alone.
authors.affiliation: Institute of Virology, Philipps University of Marburg, Marburg, Germany.
authors.forename: Tanja C
authors.initials: TC
authors.lastname: Freitag
authors.affiliation: Institute of Virology, Philipps University of Marburg, Marburg, Germany maisner@staff.uni-marburg.de.
authors.forename: Andrea
authors.initials: A
authors.lastname: Maisner
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis*; D019040:E-Selectin / Q000096:biosynthesis; D042783:Endothelial Cells / Q000187:drug effects / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology*; D054884:Host-Pathogen Interactions; D045405:Nipah Virus / Q000276:immunology*; D013552:Swine; D015854:Up-Regulation; D014764:Viral Proteins / Q000276:immunology*; D022701:Virosomes / Q000276:immunology*
chemical_list: D016207:Cytokines; D019040:E-Selectin; D006023:Glycoproteins; D014764:Viral Proteins; D022701:Virosomes