title: Kidney Injury Molecule-1 and Cardiovascular Diseases: From Basic Science to Clinical Practice.
abstract: Despite the recent findings concerning pathogenesis and novel therapeutic strategies, cardiovascular disease (CVD) still stays the leading cause of morbidity and mortality in patients with renal dysfunction, especially acute kidney injury (AKI). Early detection of patients with impaired renal function with cardiovascular risk may help ensure more aggressive treatment and improve clinical outcome. Kidney injury molecule-1 (KIM-1) is a new, promising marker of kidney damage which is currently the focus of countless studies worldwide. Some recent animal and human studies established KIM-1 as an important marker of acute tubular necrosis (ATN) and reliable predictor of development and prognosis of AKI. Food and Drug Administration (FDA) in USA acclaimed KIM-1 as an AKI biomarker for preclinical drug development. Recent data suggest the importance of monitoring of KIM-1 for early diagnosis and clinical course not only in patients with various forms of AKI and other renal diseases but also in patients with cardiorenal syndrome, heart failure, cardiopulmonary bypass, cardiothoracic surgical interventions in the pediatric emergency setting, and so forth. The aim of this review article is to summarize the literature data concerning KIM-1 as a potential novel marker in the early diagnosis and prediction of clinical outcome of certain cardiovascular diseases.
authors.affiliation: Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Dr Subotica Starijeg 1, 11129 Belgrade, Serbia.
authors.forename: Branislava
authors.initials: B
authors.lastname: Medić
authors.affiliation: Center for Endocrine Surgery, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Koste Todorovica 8, 11000 Belgrade, Serbia.
authors.forename: Branislav
authors.initials: B
authors.lastname: Rovčanin
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Belgrade, Dr Subotica Starijeg 1, 11129 Belgrade, Serbia.
authors.forename: Gordana
authors.initials: G
authors.lastname: Basta Jovanović
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Belgrade, Dr Subotica Starijeg 1, 11129 Belgrade, Serbia.
authors.forename: Sanja
authors.initials: S
authors.lastname: Radojević-Škodrić
authors.affiliation: Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Dr Subotica Starijeg 1, 11129 Belgrade, Serbia.
authors.forename: Milica
authors.initials: M
authors.lastname: Prostran
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood* / Q000209:etiology / Q000473:pathology / Q000652:urine; D015415:Biomarkers / Q000097:blood* / Q000652:urine; D059347:Cardio-Renal Syndrome / Q000097:blood / Q000473:pathology / Q000652:urine; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications / Q000473:pathology / Q000652:urine; D042241:Early Diagnosis; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D008562:Membrane Glycoproteins / Q000097:blood* / Q000652:urine; D011379:Prognosis; D011991:Receptors, Virus / Q000097:blood*
chemical_list: D015415:Biomarkers; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus