title: Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation.
abstract: Integrins are a group of heterodimeric transmembrane receptors that play essential roles in cell-cell and cell-matrix interaction. Integrins are important in many physiological processes and diseases. Integrins acquire affinity to their ligand by undergoing molecular conformational changes called activation. Here we review the molecular biomechanics during conformational changes of integrins, integrin functions in leukocyte biorheology (adhesive functions during rolling and arrest) and molecules involved in integrin activation.
authors.affiliation: Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Fan
authors.affiliation: Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.|Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Klaus
authors.initials: K
authors.lastname: Ley
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000378:metabolism; D018821:CD18 Antigens / Q000737:chemistry / Q000378:metabolism*; D002448:Cell Adhesion; D006801:Humans; D007962:Leukocytes / Q000166:cytology / Q000378:metabolism*; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D009363:Neoplasm Proteins / Q000737:chemistry / Q000378:metabolism; D020836:Protein Structure, Quaternary; D015398:Signal Transduction; D016608:Talin / Q000737:chemistry / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018821:CD18 Antigens; C477322:FERMT3 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D016608:Talin
keywords: GPCR; PSGL-1; RIAM; Rap-1; Talin; kindlin-3