title: Two new glycosides from Dryopteris fragrans with anti-inflammatory activities.
abstract: Phytochemical investigation on the aqueous extract from Dryopteris fragrans led to the isolation of one new chromone glycoside, frachromone C (1), and one new coumarin glycoside, dryofracoulin A (2), together with one known undulatoside A (3). Their structures were elucidated by a combination of 1D and 2D NMR, HRMS, and chemical analysis. Compounds 1-3 exhibited inhibition on nitric oxide production in lipopolysaccharide induced RAW 264.7 macrophages with their IC50 values of 45.8, 65.8, and 49.8 μM, respectively.
authors.affiliation: a Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine , Beijing 100010 , China.
authors.forename: Bing
authors.initials: B
authors.lastname: Peng
authors.affiliation: b Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029 , China.
authors.forename: Rui-Feng
authors.initials: RF
authors.lastname: Bai
authors.affiliation: a Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine , Beijing 100010 , China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: a Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine , Beijing 100010 , China.
authors.forename: Xu-Yang
authors.initials: XY
authors.lastname: Han
authors.affiliation: a Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine , Beijing 100010 , China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: a Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine , Beijing 100010 , China.
authors.forename: Chong-Chong
authors.initials: CC
authors.lastname: Zhu
authors.affiliation: a Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine , Beijing 100010 , China.
authors.forename: Zu-Ping
authors.initials: ZP
authors.lastname: Zeng
authors.affiliation: b Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029 , China.
authors.forename: Xing-Yun
authors.initials: XY
authors.lastname: Chai
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002867:Chromones; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032492:Dryopteris / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D002867:Chromones; D003374:Coumarins; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D008070:Lipopolysaccharides; D010936:Plant Extracts; C000608881:dryofracoulin A; C000608880:frachromone C; D009569:Nitric Oxide
keywords: Dryopteridaceae; Dryopteris fragrans; anti-inflammatory activity; isolation; structure elucidation