title: Association of the interleukin-6 gene -572G/C polymorphism with cancer risk: a meta-analysis.
abstract: The -572G/C polymorphism in interleukin-6 (IL-6) gene is associated with the development of cancer. However, previous studies have shown conflicting results; therefore, the association must be verified by an appropriate meta-analysis. For this purpose, we performed a literature search of the PubMed database to identify all reports on association between the IL-6 -572G/C polymorphism and cancer risk. Summary odds ratios (OR) and 95% confidence intervals (95%CI) were calculated for the -572G/C polymorphism and cancer in a fixed- and random-effect model, as appropriate. Publication bias was evaluated using the Begg's funnel plot. The meta-analysis was performed on the STATA (v.12.0) software. Seven studies, which analyzed 3387 cases and 4529 controls, were identified. The results of the meta-analysis showed no significant association between the -572G/C polymorphism in the IL-6 gene and cancer risk (GG vs CC: OR = 1.03, 95%CI = 0.76-1.40; GG vs CG: OR = 0.94, 95%CI = 0.82-1.09; dominant model: OR = 1.06, 95%CI = 0.92-1.21; recessive model: OR = 1.01, 95%CI = 0.86-1.18). The data were subjected to a subgroup analysis (stratified by race and cancer type), and no significant associations were found between the -572G/C polymorphism in the IL-6 gene and cancer risk. Therefore, the results of this meta-analysis suggested that the IL-6 -572G/C polymorphism was not associated with an elevated risk of cancer.
authors.affiliation: Department of Nursing, People's Hospital of Zhangqiu, Zhangqiu, Shandong Province, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Intensive Care Unit, People's Hospital of Zhangqiu, Zhangqiu, Shandong Province, China.
authors.forename: B
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Nursing, People's Hospital of Zhangqiu, Zhangqiu, Shandong Province, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Intensive Care Unit, People's Hospital of Zhangqiu, Zhangqiu, Shandong Province, China.
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Nursing, People's Hospital of Zhangqiu, Zhangqiu, Shandong Province, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Nursing, People's Hospital of Zhangqiu, Zhangqiu, Shandong Province, China.
authors.forename: H
authors.initials: H
authors.lastname: Fan
authors.affiliation: Department of Nursing, People's Hospital of Zhangqiu, Zhangqiu, Shandong Province, China.
authors.forename: S M
authors.initials: SM
authors.lastname: Li
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk
chemical_list: D015850:Interleukin-6