title: Synthesis and Evaluation of Neuroprotective Selenoflavanones.
abstract: The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier (BBB). They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments.
authors.affiliation: College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea. uriys2@gmail.com.
authors.forename: Yong-Sung
authors.initials: YS
authors.lastname: Choi
authors.affiliation: Office of Research Affairs, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03720, Korea. dongmk@yonsei.ac.kr.
authors.forename: Dong-Myung
authors.initials: DM
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea. sunshine333@naver.com.
authors.forename: Yoon-Jung
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea. saiyang871001@gmail.com.
authors.forename: Sai
authors.initials: S
authors.lastname: Yang
authors.affiliation: College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02453, Korea. ktlee@khu.ac.kr.
authors.forename: Kyung-Tae
authors.initials: KT
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02453, Korea. jhryu63@khu.ac.kr.
authors.forename: Jong Hoon
authors.initials: JH
authors.lastname: Ryu
authors.affiliation: College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Korea. organicjeong@yonsei.ac.kr.
authors.forename: Jin-Hyun
authors.initials: JH
authors.lastname: Jeong
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D044950:Flavanones / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy; D008297:Male; D008813:Mice, Inbred ICR; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D018384:Oxidative Stress; D012643:Selenium / Q000737:chemistry
chemical_list: D000975:Antioxidants; D044950:Flavanones; D018696:Neuroprotective Agents; D009942:Organometallic Compounds; D012643:Selenium
keywords: antioxidant; blood-brain barrier (BBB); flavanone; neuroprotect; selenium; selenoflavanone