title: Dewar valence isomers, the third type of environmentally relevant DNA photoproducts induced by solar radiation.
abstract: UV-induced DNA damage is the main initiating event in solar carcinogenesis. UV radiation is known to induce pyrimidine dimers in DNA, including cyclobutane dimers and (6-4) photoproducts which have been extensively studied. In contrast, much less attention has been paid to Dewar valence isomers, the photoisomerisation product of (6-4) photoproducts. Yet, the available data show that Dewar isomers can be produced by exposure to sunlight and may lead to mutations. Dewars are thus environmentally and biologically relevant. The present review summarizes currently available information on the formation, mutagenic properties and repair of this class of UV-induced DNA damage.
authors.affiliation: Univ. Grenoble Alpes, INAC, LCIB, LAN, F-38000 Grenoble, France.
authors.forename: T
authors.initials: T
authors.lastname: Douki
authors.forename: E
authors.initials: E
authors.lastname: Sage
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D004249:DNA Damage; D004260:DNA Repair; D008968:Molecular Conformation; D011743:Pyrimidines / Q000737:chemistry*; D013237:Stereoisomerism; D014466:Ultraviolet Rays
chemical_list: D011743:Pyrimidines; D004247:DNA