title: Medicated Janus fibers fabricated using a Teflon-coated side-by-side spinneret.
abstract: A family of medicated Janus fibers that provides highly tunable biphasic drug release was fabricated using a side-by-side electrospinning process employing a Teflon-coated parallel spinneret. The coated spinneret facilitated the formation of a Janus Taylor cone and in turn high quality integrated Janus structures, which could not be reliably obtained without the Teflon coating. The fibers prepared had one side consisting of polyvinylpyrrolidone (PVP) K60 and ketoprofen, and the other of ethyl cellulose (EC) and ketoprofen. To modulate and tune drug release, PVP K10 was doped into the EC side in some cases. The fibers were linear and had flat morphologies with an indent in the center. They provide biphasic drug release, with the PVP K60 side dissolving very rapidly to deliver a loading dose of the active ingredient, and the EC side resulting in sustained release of the remaining ketoprofen. The addition of PVP K10 to the EC side was able to accelerate the second stage of release; variation in the dopant amount permitted the release rate and extent this phase to be precisely tuned. These results offer the potential to rationally design systems with highly controllable drug release profiles, which can complement natural biological rhythms and deliver maximum therapeutic effects.
authors.affiliation: School of Materials Science & Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address: ydg017@usst.edu.cn.
authors.forename: Deng-Guang
authors.initials: DG
authors.lastname: Yu
authors.affiliation: School of Materials Science & Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Yang
authors.affiliation: UCL School of Pharmacy, University College London, London WC1N 1AX, UK.
authors.forename: Miao
authors.initials: M
authors.lastname: Jin
authors.affiliation: UCL School of Pharmacy, University College London, London WC1N 1AX, UK.
authors.forename: Gareth R
authors.initials: GR
authors.lastname: Williams
authors.affiliation: School of Materials Science & Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zou
authors.affiliation: School of Materials Science & Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address: wangxia@usst.edu.cn.
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.affiliation: Faculty of Science and Technology, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK. Electronic address: a.bligh@westminster.ac.uk.
authors.forename: S W Annie
authors.initials: SW
authors.lastname: Bligh
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000493:pharmacokinetics; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D065546:Drug Liberation; D055664:Electrochemical Techniques / Q000379:methods; D007660:Ketoprofen / Q000737:chemistry* / Q000493:pharmacokinetics; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D011138:Polytetrafluoroethylene / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D015203:Reproducibility of Results; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; C013517:ethyl cellulose; D011138:Polytetrafluoroethylene; D002482:Cellulose; D007660:Ketoprofen; D011205:Povidone
keywords: Janus fibers; Nano drug delivery systems; Side-by-side electrospinning; Structural nanocomposites; Teflon-coated spinneret; Tunable release rates