title: Common Medications Which Lead to Unintended Alterations in Weight Gain or Organ Lipotoxicity.
abstract: Obesity is one of the most common chronic conditions in the world. Its management is difficult, partly due to the multiple associated comorbidities including fatty liver, diabetes, hypertension, and hyperlipidemia. As a result, the choice of prescription medications in overweight and obese patients has important implications as some of them can actually worsen the fat accumulation and its associated metabolic complications. Several prescription medications are associated with weight gain with mechanisms that are often poorly understood and under-recognized. Even less data are available on the distribution of fat and lipotoxicity (the organ damage related to fat accumulation). The present review will discuss the drugs associated with weight gain, their mechanism of action, and the magnitude and timing of their effect.
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of California Davis, 4150 V Street, Sacramento, CA, 95816, USA. vmedici@ucdavis.edu.
authors.forename: Valentina
authors.initials: V
authors.lastname: Medici
authors.affiliation: Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville School of Medicine, 550 South Jackson Street, Louisville, KY, 40202, USA. samcclave@louisville.edu.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: McClave
authors.affiliation: Department of Surgery, University of Louisville, ACB 2nd Floor, 550 South Jackson Street, Louisville, KY, 40202, USA. Krmill10@gwise.louisville.edu.
authors.forename: Keith R
authors.initials: KR
authors.lastname: Miller
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D000928:Antidepressive Agents / Q000009:adverse effects; D000959:Antihypertensive Agents / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000009:adverse effects; D003276:Contraceptives, Oral / Q000009:adverse effects; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects; D050356:Lipid Metabolism / Q000187:drug effects*; D009765:Obesity / Q000139:chemically induced*; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D000928:Antidepressive Agents; D000959:Antihypertensive Agents; D014150:Antipsychotic Agents; D003276:Contraceptives, Oral; D007004:Hypoglycemic Agents
keywords: Lipotoxicity; Medications; Obesity; Side effects; Weight