title: Additional chromosomal abnormalities in core-binding factor acute myeloid leukemia.
abstract: Despite sharing a similar genetic abnormality, patients with core binding factor acute myeloid leukemia (CBF-AML), which is characterized by the presence of t(8;21) or inv(16)/t(16;16), show heterogeneous survival. Other molecular or cytogenetic factors are supposed to have an impact on the prognosis. We enrolled 24 CBF-AML patients to determine the impact of cytogenetic abnormality, and c-KIT, FLT3, NPM1, and CEBPA mutations on the prognosis. Only three patients had the c-KIT mutation (3/24, 12.5%) and one had the FLT3 mutation. However, over half of the patients (14/24) harbored additional cytogenetic changes, including ten with loss of sexual chromosomes (LOS) [all in the t(8;21) group], and six had additional abnormalities (two cases had both LOS and additional abnormalities). From this small-number study, no association was found between c-KIT mutation and survival and relapse rate. However, additional chromosome abnormalities had a significant association with relapse of the disease (P = 0.027). Stem cell transplant had a trend of benefitting patients after relapse (P = 0.065). This implies that chromosome abnormalities occur in CBF-AML and might take part in the heterogeneous nature of CBF-AML.
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung, Taiwan.|Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.|Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: H H
authors.initials: HH
authors.lastname: Hsiao
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung, Taiwan.|Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Y C
authors.initials: YC
authors.lastname: Liu
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung, Taiwan.
authors.forename: H C
authors.initials: HC
authors.lastname: Wang
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung, Taiwan.
authors.forename: Y F
authors.initials: YF
authors.lastname: Tsai
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung, Taiwan.
authors.forename: C H
authors.initials: CH
authors.lastname: Wu
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung, Taiwan.
authors.forename: S F
authors.initials: SF
authors.lastname: Cho
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung, Taiwan.
authors.forename: J F
authors.initials: JF
authors.lastname: Hsu
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung, Taiwan.
authors.forename: C T
authors.initials: CT
authors.lastname: Huang
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung, Taiwan.
authors.forename: S Y
authors.initials: SY
authors.lastname: Hsiao
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung, Taiwan.
authors.forename: C P
authors.initials: CP
authors.lastname: Lee
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung, Taiwan.|Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: C S
authors.initials: CS
authors.lastname: Chang
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung, Taiwan.|Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: S F
authors.initials: SF
authors.lastname: Lin
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung, Taiwan.|Department of Laboratory Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.|Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: T C
authors.initials: TC
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D050660:Core Binding Factors / Q000235:genetics*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009154:Mutation; D000090243:Nucleophosmin; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D055815:Young Adult
chemical_list: D050660:Core Binding Factors; C000716967:NPM1 protein, human; D000090243:Nucleophosmin; D019009:Proto-Oncogene Proteins c-kit