title: Ceruminous Adenoma of the External Auditory Canal: A Case Report with Imaging and Pathologic Findings.
abstract: Ceruminous adenomas are benign tumors that are rare in humans and present with a nonspecific symptomatology. The treatment of choice is surgical excision. We present an 87-year-old woman who presented with a reddish, tender, round, soft mass of the outer third of the inferior wall of the left external auditory canal, discharging a yellowish fluid upon pressure. Coincidentally, due to her poor general condition, this patient also showed symptoms consistent with chronic otitis media, parotitis, and cervical lymphadenopathy, such as otorrhea, through a ruptured tympanic membrane and swelling of the parotid gland and cervical lymph nodes. The external auditory canal lesion was surgically excised under general anesthesia, utilizing a transmeatal approach. The pathological diagnosis was ceruminous gland adenoma. The tumor was made of tubular and cystic structures and embedded in a fibrous, focally hyalinized stroma. Immunohistochemistry confirmed the presence of two distinct cell populations. The luminal cells expressed keratin 7, while peripheral (basal) cells expressed keratins 5/6, S100 protein, and p63. The apocrine gland-related antigen GCDFP-15 was focally expressed by tumor cells. The postoperative course was uneventful and at the 2-year follow-up no recurrence of the ceruminous adenoma was noted.
authors.affiliation: 1st Academic ENT Department, Aristotle University of Thessaloniki, AHEPA Hospital, 1 Stilponos Kyriakidi Street, 546 36 Thessaloniki, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Psillas
authors.affiliation: 1st Academic ENT Department, Aristotle University of Thessaloniki, AHEPA Hospital, 1 Stilponos Kyriakidi Street, 546 36 Thessaloniki, Greece.
authors.forename: Argyrios
authors.initials: A
authors.lastname: Krommydas
authors.affiliation: Department of Pathology, Aristotle University of Thessaloniki, School of Medicine, 541 24 Thessaloniki, Greece.
authors.forename: Georgia
authors.initials: G
authors.lastname: Karayannopoulou
authors.affiliation: Department of Pathology, Aristotle University of Thessaloniki, School of Medicine, 541 24 Thessaloniki, Greece.
authors.forename: Kyriakos
authors.initials: K
authors.lastname: Chatzopoulos
authors.affiliation: Department of Dermatology, Ed. Herriot Hospital Group, Lyon, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Kanitakis
authors.affiliation: 1st Academic ENT Department, Aristotle University of Thessaloniki, AHEPA Hospital, 1 Stilponos Kyriakidi Street, 546 36 Thessaloniki, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Markou