title: Achieving Tolerance with Perforin-Secreting Dendritic Cells.
abstract: Dendritic cells (DCs) regulate the generation of effector adaptive immunity and enforce peripheral tolerance. In the October 2015 issue of Immunity, Zlotnikov-Klionsky et al. present exciting data describing a population of perforin-expressing CD11c(+)DCs that limit obesity as well as metabolic and autoimmune inflammation in mice.
authors.affiliation: Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
authors.forename: Maisa C
authors.initials: MC
authors.lastname: Takenaka
authors.affiliation: Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: fquintana@rics.bwh.harvard.edu.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Quintana
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D007249:Inflammation / Q000276:immunology*; D008297:Male; D024821:Metabolic Syndrome / Q000276:immunology*; D052899:Pore Forming Cytotoxic Proteins / Q000032:analysis*
chemical_list: D052899:Pore Forming Cytotoxic Proteins