title: Development and physicochemical characterization of alginate composite film loaded with simvastatin as a potential wound dressing.
abstract: Previously, studies have demonstrated that topical application of simvastatin can promote wound healing in diabetic mice via augmentation of angiogenesis and lymphangiogenesis. This study aimed to formulate and characterize simvastatin in alginate-based composite film wound dressings. Biopolymers used for composite films were sodium alginate blended with pectin or gelatin. The films were prepared and characterized based on their physical properties, surface morphology, mechanical strength and rheology. Then, in vitro drug releases from the films were investigated and, finally, the cell viability assay was performed to assess the cytotoxicity profile. From the pre-formulation studies, alginate/pectin composite film showed to possess desirable wound dressing properties and superior mechanical properties. The in vitro drug release profile revealed that alginate/pectin film produced a controlled release drug profile, and cell viability assay showed that the film was non-toxic. In summary, alginate/pectin composite film is suitable to be formulated with simvastatin as a potential wound dressing.
authors.affiliation: Centre of Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
authors.forename: Masoud
authors.initials: M
authors.lastname: Rezvanian
authors.affiliation: Centre of Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
authors.forename: Mohd Cairul Iqbal Mohd
authors.initials: MCIM
authors.lastname: Amin
authors.affiliation: Centre of Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia. Electronic address: nsfern@gmail.com.
authors.forename: Shiow-Fern
authors.initials: SF
authors.lastname: Ng
mesh_terms: D000464:Alginates / Q000737:chemistry*; D001458:Bandages; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D010368:Pectins / Q000737:chemistry; D019821:Simvastatin / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D014945:Wound Healing / Q000187:drug effects; D014961:X-Ray Diffraction
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D010368:Pectins; D020723:Glucuronic Acid; D019821:Simvastatin
keywords: Alginate; Composite film; Film wound dressing; Pectin; Simvastatin