title: Michael Reaction of 3-aAryl-2,4-Dicarboethoxy-5-Hydroxy-5-Methylcyclohexanones.
abstract: The reaction of 3-aryl-2,4-dicarboethoxy-5-hydroxy-5-methylcyclohexanones1with benzalacetone, dibenzalacetone, benzalacetophenone, and 4-benzal-1-phenyl-3-methyl pyrazolone has been investigated to give Michael compounds2-5. hydrolysis of the dioxo derivative4afforded1,5-dicarbonyl derivative6which On condensation with hydrazine and/or substituted hydrazine and hydroxylamine produced1,2-diazepine and 1,2-oxazepine derivatives7,8respectively. Reaction of β-Keto ester1with 1,3-diphenylacetone afforded9. The structures of the hitherto unknown compounds have been confirmed by analytical and spectral data. The newly synthesized compounds have been screened to test their antimicrobial and antifungal activity.
authors.affiliation: Department of Chemistry, Damietta Faculty of Science, Damietta University, Egypt.
authors.forename: Fawzia Zakaria
authors.initials: FZ
authors.lastname: El-Ablack
authors.affiliation: Department of Chemistry, Mansoura Faculty of science, Mansoura University, Egypt.
authors.forename: M A
authors.initials: MA
authors.lastname: Metwally
authors.affiliation: Department of Chemistry, Mansoura Faculty of science, Mansoura University, Egypt.
authors.forename: A M
authors.initials: AM
authors.lastname: Khalil
keywords: 1,2-diazepine; 1,2-oxazepine; Michael addition; Michael adduct; and antifungal activity; antibacterial; dioxo