title: Occurrence of Wilms' tumor in a child with hereditary spherocytosis.
abstract: Hereditary spherocytosis (HS) is the most frequent cause of congenital hemolytic anemia. It is an autosomal dominant genetic disorder characterized by cell membrane abnormalities, specifically in red blood cells. Although the association between benign, borderline and malignant tumors and HS is not clear, various tumors such as splenoma, adrenal myolipoma, pancreatic schwannoma, ganglioneuroma, extramedullary hematopoiesis, myeloproliferative disorders, multiple myeloma, B-cell lymphoma and acute lymphoblastic leukemia have been presented in case reports concerning HS patients. Here we describe a 6-year-old boy with HS who presented with a mass in the left kidney. Tru-cut biopsy revealed Wilms' tumor (WT). To the best of our knowledge, this is the first case of WT associated with HS to be reported in the literature.
authors.affiliation: Division of Pediatric Oncology, Department of Pediatrics, Ankara Children's Hematology and Oncology Hospital, Ankara, Turkey. dozyoruk@yahoo.com.
authors.forename: Derya
authors.initials: D
authors.lastname: Özyörük
authors.forename: Hacı Ahmet
authors.initials: HA
authors.lastname: Demir
authors.forename: Suna
authors.initials: S
authors.lastname: Emir
authors.forename: Esra
authors.initials: E
authors.lastname: Karakuş
authors.forename: Bahattin
authors.initials: B
authors.lastname: Tunç
mesh_terms: D001706:Biopsy; D002648:Child; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008297:Male; D013103:Spherocytosis, Hereditary / Q000150:complications* / Q000628:therapy; D009396:Wilms Tumor / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy