title: Green Synthesis of Silver Nanorods and Optimization of Its Therapeutic Cum Toxic Dose.
abstract: Germinated Fenugreek seeds are relatively rich in flavonoids and polyphenols than dry seeds. Therefore, germinated fenugreek seeds possess better pharmacological activities. We have used an aqueous extract of germinated fenugreek seeds to reduce silver nitrate into nanoscale silver rods. The silver nanorods showed Surface Plasmon peak at 450 nm as revealed from UV visible spectrum. Field Emission Scanning Electron Microscopy images revealed the monodispersity and rod morphology. X ray diffraction spectrum revealed the FCC crystal structure of nanorods. Fourier transform infrared spectroscopy peaks revealed the interaction between the phytochemicals of germinated fenugreek seeds and the silver nanorods. Characterization studies reveal the validation of the proposed green synthesis protocol to produce monodispersed silver nanorods with phytochemical capping. The phytosynthesized silver nanorods exhibited anticancer activity in skin cancer cell line, which may be due to its nanoscale dimension and the surface functionalization. For the first time, we have optimized the therapeutic cum toxic dose of phytostabilized silver nanorods using skin cancer cell model.
authors.forename: T R
authors.initials: TR
authors.lastname: Suganya
authors.forename: T
authors.initials: T
authors.lastname: Devasena
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D055772:Green Chemistry Technology; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D012834:Silver / Q000494:pharmacology*; D012835:Silver Nitrate / Q000737:chemistry; D012878:Skin Neoplasms / Q000188:drug therapy; D017550:Spectroscopy, Fourier Transform Infrared; D029910:Trigonella / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D012834:Silver; D012835:Silver Nitrate