title: Glioma Stem-like Cells Keep Their H3.3 Variant Levels at Bay.
abstract: Pediatric glioblastomas (GBMs) commonly harbor mutations in histone variant H3.3, while adult GBMs do not. In this issue of Cancer Cell, Gallo and colleagues demonstrate that adult GBM stem-like cells repress H3.3 expression to maintain self-renewal properties.
authors.affiliation: Division of Pediatric Hematology-Oncology, Duke University Medical Center, Durham, NC 27710, USA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: oren.becher@duke.edu.
authors.forename: Oren J
authors.initials: OJ
authors.lastname: Becher
authors.affiliation: Division of Human Biology, Solid Tumor and Translational Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Alvord Brain Tumor Center, University of Washington, Seattle, WA 98104, USA. Electronic address: eholland@fhcrc.org.
authors.forename: Eric C
authors.initials: EC
authors.lastname: Holland
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism*; D000066673:Cell Self Renewal; D042002:Chromatin Assembly and Disassembly; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005909:Glioblastoma / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D006657:Histones