title: Discovery and Current Status of Evaluation System of Bioavailability and Related Pharmaceutical Technologies for Traditional Chinese Medicines--Flos Lonicerae Japonicae--Fructus Forsythiae Herb Couples as an Example.
abstract: Traditional Chinese medicines (TCMs) have attracted extensive interest throughout the world due to their long history of health protection and disease control, and the internalization of TCM preparations or patented drugs has been considered a wind vane in the process of TCM modernization. However, multi-target effects, caused by multiple components in TCMs, hinder not only the construction of the quality evaluation system (bioavailability), but also the application of pharmaceutical technologies, which results in the poor efficacy in clinical practice. This review describes the methods in the literature as well as in our thoughts about how to identify the marker components, establish the evaluation system of bioavailability, and improve the bioavailability in TCM preparations. We expect that the current study will be positive and informative.
authors.affiliation: College of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. zhouwei19860506@163.com.|Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing 210023, China. zhouwei19860506@163.com.|Nanjing Engineering Research Center for Industrialization of Chinese Medicine Pellets, Nanjing 210023, China. zhouwei19860506@163.com.|Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China. zhouwei19860506@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.affiliation: College of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. bccai@126.com.|Nanjing Haichang Chinese Medicine Group Co., Ltd., Nanjing 210023, China. bccai@126.com.
authors.forename: Baochang
authors.initials: B
authors.lastname: Cai
authors.affiliation: Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China. dfsjj@163.com.
authors.forename: Jinjun
authors.initials: J
authors.lastname: Shan
authors.affiliation: Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China. wscnj@126.com.
authors.forename: Shouchuan
authors.initials: S
authors.lastname: Wang
authors.affiliation: College of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. diliuqing@hotmail.com.|Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing 210023, China. diliuqing@hotmail.com.|Nanjing Engineering Research Center for Industrialization of Chinese Medicine Pellets, Nanjing 210023, China. diliuqing@hotmail.com.|Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China. diliuqing@hotmail.com.
authors.forename: Liuqing
authors.initials: L
authors.lastname: Di
mesh_terms: D000818:Animals; D001682:Biological Availability; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000493:pharmacokinetics*; D031657:Forsythia / Q000737:chemistry*; D006801:Humans; D031239:Lonicera / Q000737:chemistry*; D008516:Medicine, Chinese Traditional / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D004365:Drugs, Chinese Herbal
keywords: absorption enhancer; active constitutes identification; bio-pharmaceutics of TCMs preparations; evaluation system of bioavailability; pharmaceutical technologies