title: Monitoring/Imaging and Regenerative Agents for Enhancing Tissue Engineering Characterization and Therapies.
abstract: The past three decades have seen numerous advances in tissue engineering and regenerative medicine (TERM) therapies. However, despite the successes there is still much to be done before TERM therapies become commonplace in clinic. One of the main obstacles is the lack of knowledge regarding complex tissue engineering processes. Imaging strategies, in conjunction with exogenous contrast agents, can aid in this endeavor by assessing in vivo therapeutic progress. The ability to uncover real-time treatment progress will help shed light on the complex tissue engineering processes and lead to development of improved, adaptive treatments. More importantly, the utilized exogenous contrast agents can double as therapeutic agents. Proper use of these Monitoring/Imaging and Regenerative Agents (MIRAs) can help increase TERM therapy successes and allow for clinical translation. While other fields have exploited similar particles for combining diagnostics and therapy, MIRA research is still in its beginning stages with much of the current research being focused on imaging or therapeutic applications, separately. Advancing MIRA research will have numerous impacts on achieving clinical translations of TERM therapies. Therefore, it is our goal to highlight current MIRA progress and suggest future research that can lead to effective TERM treatments.
authors.affiliation: Department of Biomedical Engineering, University of Texas at Austin, 107 W. Dean Keeton, BME Building, 1 University Station, C0800, Austin, TX, 78712, USA.|Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University School of Medicine, 313 Ferst Dr NW, Atlanta, GA, 30332, USA.
authors.forename: Daniela Y
authors.identifier: http://orcid.org/0000-0001-9388-5722
authors.initials: DY
authors.lastname: Santiesteban
authors.affiliation: School of Electrical and Computer Engineering, Georgia Institute of Technology, 777 Atlantic Drive NW, Atlanta, GA, 30332, USA.|Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University School of Medicine, 313 Ferst Dr NW, Atlanta, GA, 30332, USA.
authors.forename: Kelsey
authors.initials: K
authors.lastname: Kubelick
authors.affiliation: Department of Biomedical Engineering, University of Texas at Austin, 107 W. Dean Keeton, BME Building, 1 University Station, C0800, Austin, TX, 78712, USA.
authors.forename: Kabir S
authors.initials: KS
authors.lastname: Dhada
authors.affiliation: School of Electrical and Computer Engineering, Georgia Institute of Technology, 777 Atlantic Drive NW, Atlanta, GA, 30332, USA.|Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University School of Medicine, 313 Ferst Dr NW, Atlanta, GA, 30332, USA.
authors.forename: Diego
authors.initials: D
authors.lastname: Dumani
authors.affiliation: Department of Biomedical Engineering, University of Texas at Austin, 107 W. Dean Keeton, BME Building, 1 University Station, C0800, Austin, TX, 78712, USA. laura.suggs@mail.utexas.edu.
authors.forename: Laura
authors.initials: L
authors.lastname: Suggs
authors.affiliation: School of Electrical and Computer Engineering, Georgia Institute of Technology, 777 Atlantic Drive NW, Atlanta, GA, 30332, USA. emelian@mail.utexas.edu.|Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University School of Medicine, 313 Ferst Dr NW, Atlanta, GA, 30332, USA. emelian@mail.utexas.edu.
authors.forename: Stanislav
authors.initials: S
authors.lastname: Emelianov
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000627:therapeutic use*; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D003287:Contrast Media
keywords: Imaging contrast agents; In vivo imaging; In vivo tracking; Multimodal tracking; Real-time imaging; Regenerative medicine; Scaffold engineering; Stem cells; Therapeutic agents