title: Redox Changes Induced by General Anesthesia in Critically Ill Patients with Multiple Traumas.
abstract: The critically ill polytrauma patient is a constant challenge for the trauma team due to the complexity of the complications presented. Intense inflammatory response and infections, as well as multiple organ dysfunctions, significantly increase the rate of morbidity and mortality in these patients. Moreover, due to the physiological and biochemical imbalances present in this type of patients, the bioproduction of free radicals is significantly accelerated, thus installing the oxidative stress. In the therapeutic management of such patients, multiple surgical interventions are required and therefore they are being subjected to repeated general anesthesia. In this paper, we want to present the pathophysiological implications of oxidative stress in critically ill patients with multiple traumas and the implications of general anesthesia on the redox mechanisms of the cell. We also want to summarize the antioxidant treatments able to reduce the intensity of oxidative stress by modulating the biochemical activity of some cellular mechanisms.
authors.affiliation: Clinic of Anesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", 300736 Timisoara, Romania ; Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
authors.forename: Marius
authors.initials: M
authors.lastname: Papurica
authors.affiliation: Clinic of Anesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", 300736 Timisoara, Romania ; Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
authors.forename: Alexandru Florin
authors.initials: AF
authors.lastname: Rogobete
authors.affiliation: Clinic of Anesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", 300736 Timisoara, Romania ; Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
authors.forename: Dorel
authors.initials: D
authors.lastname: Sandesc
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
authors.forename: Raluca
authors.initials: R
authors.lastname: Dumache
authors.affiliation: Faculty of Chemistry, Biology, Geography, West University of Timisoara, 300115 Timisoara, Romania.
authors.forename: Radu
authors.initials: R
authors.lastname: Nartita
authors.affiliation: Clinic of Anesthesia and Intensive Care "Casa Austria", Emergency County Hospital "Pius Brinzeu", 300736 Timisoara, Romania.
authors.forename: Mirela
authors.initials: M
authors.lastname: Sarandan
authors.affiliation: Clinic of Anesthesia and Intensive Care "Casa Austria", Emergency County Hospital "Pius Brinzeu", 300736 Timisoara, Romania.
authors.forename: Alina Carmen
authors.initials: AC
authors.lastname: Cradigati
authors.affiliation: Clinic of Anesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", 300736 Timisoara, Romania.
authors.forename: Loredana
authors.initials: L
authors.lastname: Luca
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
authors.forename: Corina
authors.initials: C
authors.lastname: Vernic
authors.affiliation: Clinic of Anesthesia and Intensive Care, Emergency County Hospital "Pius Brinzeu", 300736 Timisoara, Romania ; Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
authors.forename: Ovidiu Horea
authors.initials: OH
authors.lastname: Bedreag