title: [Transdermal Local Anesthetics].
abstract: Taking EMLA cream and Penles tape 18 mg as examples, this article describes the conditions for skin penetration of topical anesthetics, with their onset time of action, duration of effect and a precautions for their use. EMLA cream is a unique cream for topical anesthesia which is the eutectic mixture of lidocaine and propitocaine to increase skin penetration. The safety study demonstrated that blood concentrations of active ingredients of EMLA cream were below toxic levels. EMLA cream, with confirmed high skin penetrability and safety, should be used for pain reduction of various treatments for many diseases. Here in Japan, EMLA cream has indications not only for pain reduction of skin laser therapy but also for reduction of needle puncture pain. This means the use of topical anesthesia would be expanded to wider ranges of treatments.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hanaoka
authors.forename: Hideko
authors.initials: H
authors.lastname: Arita
authors.forename: Masaki
authors.initials: M
authors.lastname: Nagase
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Sestsuro
authors.initials: S
authors.lastname: Ogawa
mesh_terms: D000279:Administration, Cutaneous; D000772:Anesthesia, Local / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000378:metabolism*; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000378:metabolism; D008297:Male; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D012867:Skin / Q000378:metabolism*
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine