title: The Immunologic Complexity of Growing Up with Malaria--Is Scientific Understanding Coming of Age?
abstract: In the current issue of Clinical and Vaccine Immunology, Mandala et al. report changes in lymphocyte populations in children with uncomplicated malaria, severe malarial anemia, and cerebral malaria compared to controls (W. L. Mandala et al., Clin Vaccine Immunol 23:95-103, 2016, http://dx.doi.org/10.1128/CVI.00564-15). This commentary discusses the importance of understanding both helpful and detrimental aspects of the antimalarial immune response that are critical to malaria vaccine development and considers how these responses may relate to antimalarial vaccine safety and efficacy.
authors.affiliation: Division of Malaria Research and Center for Vaccine Development, Institute for Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA mlaurens@medicine.umaryland.edu.
authors.forename: Matthew B
authors.identifier: http://orcid.org/0000-0003-3874-581X
authors.initials: MB
authors.lastname: Laurens
mesh_terms: D000740:Anemia; D000962:Antimalarials; D006801:Humans; D017780:Malaria Vaccines; D016779:Malaria, Cerebral; D016778:Malaria, Falciparum
chemical_list: D000962:Antimalarials; D017780:Malaria Vaccines