title: Iris-fixated phakic intraocular lens implantation to correct myopia and a predictive model of endothelial cell loss.
abstract: OBJECTIVE
  To report long-term results of Artisan phakic intraocular lens (pIOL) to correct myopia and to propose a model predicting endothelial cell loss after pIOL implantation.
  
  
  METHODS
  Quinze-Vingts National Ophthalmology Hospital, Paris, France.
  
  
  METHODS
  Retrospective, interventional case series.
  
  
  METHODS
  Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and central endothelial cell count (ECC) were determined before and at yearly intervals up to 5 years after pIOL implantation. Linear model analysis was performed to present a model that describes endothelial cell loss as a linear decrease and an additional decrease depending on postoperative loss.
  
  
  RESULTS
  A total of 49 patients (68 eyes) implanted with pIOLs from January 2000 to January 2009 were evaluated. The mean preoperative and final spherical equivalent (SE) were -13 ± 4.10 and -0.75 ± 0.74 diopters (D), respectively. The mean preoperative and final central ECC were 2629 ± 366 and 2250 ± 454 cells/mm(2), respectively. There were no intraoperative complications for any of the eyes. One eye required surgery for repositioning the pIOL, and 1 eye required pIOL exchange for postoperative refractive error. The model predicted that for patients with preoperative ECC of 3000, 2500, and 2000 cells/mm(2), a critical ECC of 1500 cells/mm(2) will be reached at 39, 28, and 15 years after implantation, respectively.
  
  
  CONCLUSIONS
  Implantation of the pIOL was an effective and stable procedure after 5 years of follow-up. The presented model predicted EC loss after pIOL implantation, which can assist ophthalmologists in patient selection and follow-up.
  
  
  BACKGROUND
  The authors report no conflict of interest.
authors.affiliation: From the Quinze-Vingts National Ophthalmology Hospital (Bouheraoua, Bonnet, Sandali, Lecuen, Ameline, Borderie, Laroche), Sorbonne Universités, UPMC Univ Paris 06, Paris, France; INSERM UMR S 968 (Bouheraoua, Labbé, Borderie, Laroche), Institut de la Vision, Paris, France; Sorbonne Universités (Bouheraoua, Labbé, Borderie, Laroche), UPMC Univ Paris 06, UMR S 968, Institut de la Vision, Paris, France; CNRS (Bouheraoua, Labbé, Borderie, Laroche), UMR 7210, Paris, France; Quinze-Vingts National Ophthalmology Hospital (Labbé), and Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, Versailles, France. Electronic address: nacim.bouheraoua@gmail.com.
authors.forename: Nacim
authors.initials: N
authors.lastname: Bouheraoua
authors.affiliation: From the Quinze-Vingts National Ophthalmology Hospital (Bouheraoua, Bonnet, Sandali, Lecuen, Ameline, Borderie, Laroche), Sorbonne Universités, UPMC Univ Paris 06, Paris, France; INSERM UMR S 968 (Bouheraoua, Labbé, Borderie, Laroche), Institut de la Vision, Paris, France; Sorbonne Universités (Bouheraoua, Labbé, Borderie, Laroche), UPMC Univ Paris 06, UMR S 968, Institut de la Vision, Paris, France; CNRS (Bouheraoua, Labbé, Borderie, Laroche), UMR 7210, Paris, France; Quinze-Vingts National Ophthalmology Hospital (Labbé), and Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, Versailles, France.
authors.forename: Clemence
authors.initials: C
authors.lastname: Bonnet
authors.affiliation: From the Quinze-Vingts National Ophthalmology Hospital (Bouheraoua, Bonnet, Sandali, Lecuen, Ameline, Borderie, Laroche), Sorbonne Universités, UPMC Univ Paris 06, Paris, France; INSERM UMR S 968 (Bouheraoua, Labbé, Borderie, Laroche), Institut de la Vision, Paris, France; Sorbonne Universités (Bouheraoua, Labbé, Borderie, Laroche), UPMC Univ Paris 06, UMR S 968, Institut de la Vision, Paris, France; CNRS (Bouheraoua, Labbé, Borderie, Laroche), UMR 7210, Paris, France; Quinze-Vingts National Ophthalmology Hospital (Labbé), and Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, Versailles, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Labbé
authors.affiliation: From the Quinze-Vingts National Ophthalmology Hospital (Bouheraoua, Bonnet, Sandali, Lecuen, Ameline, Borderie, Laroche), Sorbonne Universités, UPMC Univ Paris 06, Paris, France; INSERM UMR S 968 (Bouheraoua, Labbé, Borderie, Laroche), Institut de la Vision, Paris, France; Sorbonne Universités (Bouheraoua, Labbé, Borderie, Laroche), UPMC Univ Paris 06, UMR S 968, Institut de la Vision, Paris, France; CNRS (Bouheraoua, Labbé, Borderie, Laroche), UMR 7210, Paris, France; Quinze-Vingts National Ophthalmology Hospital (Labbé), and Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, Versailles, France.
authors.forename: Otman
authors.initials: O
authors.lastname: Sandali
authors.affiliation: From the Quinze-Vingts National Ophthalmology Hospital (Bouheraoua, Bonnet, Sandali, Lecuen, Ameline, Borderie, Laroche), Sorbonne Universités, UPMC Univ Paris 06, Paris, France; INSERM UMR S 968 (Bouheraoua, Labbé, Borderie, Laroche), Institut de la Vision, Paris, France; Sorbonne Universités (Bouheraoua, Labbé, Borderie, Laroche), UPMC Univ Paris 06, UMR S 968, Institut de la Vision, Paris, France; CNRS (Bouheraoua, Labbé, Borderie, Laroche), UMR 7210, Paris, France; Quinze-Vingts National Ophthalmology Hospital (Labbé), and Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, Versailles, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lecuen
authors.affiliation: From the Quinze-Vingts National Ophthalmology Hospital (Bouheraoua, Bonnet, Sandali, Lecuen, Ameline, Borderie, Laroche), Sorbonne Universités, UPMC Univ Paris 06, Paris, France; INSERM UMR S 968 (Bouheraoua, Labbé, Borderie, Laroche), Institut de la Vision, Paris, France; Sorbonne Universités (Bouheraoua, Labbé, Borderie, Laroche), UPMC Univ Paris 06, UMR S 968, Institut de la Vision, Paris, France; CNRS (Bouheraoua, Labbé, Borderie, Laroche), UMR 7210, Paris, France; Quinze-Vingts National Ophthalmology Hospital (Labbé), and Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, Versailles, France.
authors.forename: Barbara
authors.initials: B
authors.lastname: Ameline
authors.affiliation: From the Quinze-Vingts National Ophthalmology Hospital (Bouheraoua, Bonnet, Sandali, Lecuen, Ameline, Borderie, Laroche), Sorbonne Universités, UPMC Univ Paris 06, Paris, France; INSERM UMR S 968 (Bouheraoua, Labbé, Borderie, Laroche), Institut de la Vision, Paris, France; Sorbonne Universités (Bouheraoua, Labbé, Borderie, Laroche), UPMC Univ Paris 06, UMR S 968, Institut de la Vision, Paris, France; CNRS (Bouheraoua, Labbé, Borderie, Laroche), UMR 7210, Paris, France; Quinze-Vingts National Ophthalmology Hospital (Labbé), and Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, Versailles, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Borderie
authors.affiliation: From the Quinze-Vingts National Ophthalmology Hospital (Bouheraoua, Bonnet, Sandali, Lecuen, Ameline, Borderie, Laroche), Sorbonne Universités, UPMC Univ Paris 06, Paris, France; INSERM UMR S 968 (Bouheraoua, Labbé, Borderie, Laroche), Institut de la Vision, Paris, France; Sorbonne Universités (Bouheraoua, Labbé, Borderie, Laroche), UPMC Univ Paris 06, UMR S 968, Institut de la Vision, Paris, France; CNRS (Bouheraoua, Labbé, Borderie, Laroche), UMR 7210, Paris, France; Quinze-Vingts National Ophthalmology Hospital (Labbé), and Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, Versailles, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Laroche
mesh_terms: D000328:Adult; D002452:Cell Count; D055954:Corneal Endothelial Cell Loss / Q000175:diagnosis*; D004728:Endothelium, Corneal / Q000473:pathology; D005260:Female; D006801:Humans; D007498:Iris / Q000601:surgery*; D019654:Lens Implantation, Intraocular / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D009216:Myopia / Q000601:surgery*; D054120:Phakic Intraocular Lenses; D012189:Retrospective Studies; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult