title: The Biochemical Evolution of Protein Complexes.
abstract: Over the past decade, it became evident that proteins perform critical functions as components of specialized macromolecular complexes. Here, we discuss a recent study by Wan and colleagues, which highlights the significance of protein complexes by studying their conservation in organisms separated by up to a billion years of evolution.
authors.affiliation: Department of Molecular Biology, 210 Lewis Thomas Laboratory, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Greco
authors.affiliation: Department of Molecular Biology, 210 Lewis Thomas Laboratory, Princeton University, Princeton, NJ 08544, USA. Electronic address: icristea@princeton.edu.
authors.forename: Ileana M
authors.initials: IM
authors.lastname: Cristea
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D046912:Multiprotein Complexes / Q000737:chemistry* / Q000378:metabolism*; D060066:Protein Interaction Maps
chemical_list: D046912:Multiprotein Complexes
keywords: Protein interactions; evolution; interactome; macromolecular complex; mass spectrometry; protein-protein interaction