title: Engineering β-sheet peptide assemblies for biomedical applications.
abstract: Hydrogels have been widely studied in various biomedical applications, such as tissue engineering, cell culture, immunotherapy and vaccines, and drug delivery. Peptide-based nanofibers represent a promising new strategy for current drug delivery approaches and cell carriers for tissue engineering. This review focuses on the recent advances in the use of self-assembling engineered β-sheet peptide assemblies for biomedical applications. The applications of peptide nanofibers in biomedical fields, such as drug delivery, tissue engineering, immunotherapy, and vaccines, are highlighted. The current challenges and future perspectives for self-assembling peptide nanofibers in biomedical applications are discussed.
authors.affiliation: School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510515, China. Liusw@smu.edu.cn.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Yu
authors.affiliation: School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510515, China. Liusw@smu.edu.cn.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Cai
authors.affiliation: School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510515, China. Liusw@smu.edu.cn.
authors.forename: Qiling
authors.initials: Q
authors.lastname: Chen
authors.affiliation: School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510515, China. Liusw@smu.edu.cn.
authors.forename: Menghua
authors.initials: M
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510515, China. Liusw@smu.edu.cn.
authors.forename: Ling
authors.initials: L
authors.lastname: Ye
authors.affiliation: Department of Food Science and Technology, South China University of Technology, Wushan Road 381, Guangzhou, Guangdong, China. wenzhenliao@163.com.
authors.forename: Jiaoyan
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Food Science and Technology, South China University of Technology, Wushan Road 381, Guangzhou, Guangdong, China. wenzhenliao@163.com.
authors.forename: Wenzhen
authors.initials: W
authors.lastname: Liao
authors.affiliation: School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510515, China. Liusw@smu.edu.cn.
authors.forename: Shuwen
authors.initials: S
authors.lastname: Liu
mesh_terms: D018929:Cell Culture Techniques; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry* / Q000494:pharmacology; D007167:Immunotherapy; D057139:Nanofibers / Q000627:therapeutic use*; D000072757:Protein Conformation, beta-Strand; D023822:Tissue Engineering; D014612:Vaccines / Q000737:chemistry*
chemical_list: D020100:Hydrogels; D014612:Vaccines