title: Can Breast Tumors Affect the Oxidative Status of the Surrounding Environment? A Comparative Analysis among Cancerous Breast, Mammary Adjacent Tissue, and Plasma.
abstract: In this paper, we investigated the oxidative profile of breast tumors in comparison with their normal adjacent breast tissue. Our study indicates that breast tumors present enhanced oxidative/nitrosative stress, with concomitant augmented antioxidant capacity when compared to the adjacent normal breast. These data indicate that breast cancers may be responsible for the induction of a prooxidant environment in the mammary gland, in association with enhanced TNF-α and nitric oxide.
authors.affiliation: Laboratory of Inflammatory Mediators, State University of West Paraná (UNIOESTE), Campus Francisco Beltrão, 85605-010 Francisco Beltrão, PR, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: Panis
authors.affiliation: School of Medicine, State University of Sao Paulo (USP), 07112-000 São Paulo, SP, Brazil.
authors.forename: V J
authors.initials: VJ
authors.lastname: Victorino
authors.affiliation: School of Medicine, Pontifícia Universidade Católica (PUC), Campus Londrina, 86051-990 Londrina, PR, Brazil.
authors.forename: A C S A
authors.initials: AC
authors.lastname: Herrera
authors.affiliation: Laboratory of Physiopathology and Free Radicals, Department of General Pathology, State University of Londrina (UEL), 86051-990 Londrina, PR, Brazil.
authors.forename: A L
authors.initials: AL
authors.lastname: Cecchini
authors.affiliation: University Hospital, Department of Pharmacy, State University of Londrina (UEL), 86051-990 Londrina, PR, Brazil.
authors.forename: A N C
authors.initials: AN
authors.lastname: Simão
authors.affiliation: Department of Preventive Medicine, Federal University of São Paulo (UNIFESP), 07112-000 São Paulo, SP, Brazil.
authors.forename: L Y
authors.initials: LY
authors.lastname: Tomita
authors.affiliation: Laboratory of Physiopathology and Free Radicals, Department of General Pathology, State University of Londrina (UEL), 86051-990 Londrina, PR, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Cecchini
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001940:Breast / Q000378:metabolism / Q000473:pathology*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006710:Homocysteine / Q000032:analysis; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000032:analysis; D042361:Mammary Glands, Human / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis; D018384:Oxidative Stress; D050050:Protein Carbonylation; D012372:ROC Curve; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D014409:Tumor Necrosis Factor-alpha; D006710:Homocysteine; D009569:Nitric Oxide; D008315:Malondialdehyde