title: Hemozoin Detection for Human Malaria Diagnosis Investigated in Rodent Models: How Similar Is Similar?
abstract: New malaria diagnostic methods based on hemozoin (Hz) detection have been reported recently and were investigated in rodent models. These models are likely to produce unduly favorable results compared to the reality of Plasmodium falciparum malaria. Thus, for malaria diagnostics, results from rodent malaria experiments must be interpreted with caution.
authors.affiliation: Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisbon, Portugal. Electronic address: t.hanscheid@medicina.ulisboa.pt.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hänscheid
authors.affiliation: Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisbon, Portugal.
authors.forename: Tânia
authors.initials: T
authors.lastname: Carvalho
authors.affiliation: Center for Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, PO Box 22660, Amsterdam, DD 1100 The Netherlands.
authors.forename: Martin P
authors.initials: MP
authors.lastname: Grobusch
mesh_terms: D000818:Animals; D019937:Diagnostic Techniques and Procedures / Q000592:standards; D004195:Disease Models, Animal; D006420:Hemeproteins / Q000032:analysis*; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000175:diagnosis*; D010963:Plasmodium falciparum; D015203:Reproducibility of Results
chemical_list: D006420:Hemeproteins; C020753:hemozoin
keywords: diagnosis; hemozoin; laboratory medicine; malaria; rodent models; validation studies