title: PET Neurochemical Imaging Modes.
abstract: PET has deep roots in neuroscience stemming from its first application in brain tumor and brain metabolism imaging. PET emerged over the past few decades and continues to play a prominent role in the study of neurochemistry in the living human brain. Over time, neurochemical imaging with PET has been expanded to address a host of research questions related to, among many others, protein density, drug occupancy, and endogenous neurochemical release. Each of these imaging modes has distinct design and analysis considerations that are critical for enabling quantitative measurements. The number of considerations required for a neurochemical PET study can make it unapproachable. This article aims to orient those interested in neurochemical PET imaging to three of the common imaging modes and to provide some perspective on needs that exist for expansion of neurochemical PET imaging.
authors.affiliation: Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA; Department of Psychiatry, McLean Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Placzek
authors.affiliation: Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA.
authors.forename: Hsiao-Ying
authors.initials: HY
authors.lastname: Wey
authors.affiliation: Department of Psychology, Tufts University, Medford, MA.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Morin
authors.affiliation: Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA. Electronic address: hooker@nmr.mgh.harvard.edu.
authors.forename: Jacob M
authors.initials: JM
authors.lastname: Hooker
mesh_terms: D000818:Animals; D006801:Humans; D009448:Neurochemistry / Q000379:methods*; D018377:Neurotransmitter Agents / Q000378:metabolism; D049268:Positron-Emission Tomography / Q000379:methods*; D011506:Proteins / Q000378:metabolism; D011849:Radioactive Tracers
chemical_list: D018377:Neurotransmitter Agents; D011506:Proteins; D011849:Radioactive Tracers