title: [Evaluation of the efficacy of medical screening of blood donors on preventing blood transfusion-transmitted infectious agents].
abstract: BACKGROUND
  The aim of this study was to evaluate the efficacy of medical screening to retain blood donors in window period by comparing the seroprevalence of infectious agents (HIV, hepatitis B and C, syphilis) in deferred versus accepted blood donors.
  
  
  METHODS
  This prospective and transversal study was performed during 4 months in the National Blood Transfusion Center in Dakar (Senegal). We conducted a convenience sampling comparing the seroprevalence of infectious agents (HIV, HBsAg, HCV and syphilis) in deferred versus accepted blood donors after medical selection.
  
  
  RESULTS
  In total, 8219 blood donors were included. Medical selection had authorized 8048 donors (97.92%) and deferred donors were 171 (2.08%). The prevalence of HIV was higher in the deferred than in accepted blood donors (1.75% vs. 0.05%) (P=0.0003; OR=35.91), as well as for HBsAg (12.87% vs. 7.35%) (P=0.006; OR=1.86). HCV antibodies were present in 0.71% of accepted blood donors and 0.58% in deferred blood donors (P=0.65; OR=0.82). Only accepted donors had brought the infection of syphilis (0.34%) (P=0.56; OR=0).
  
  
  CONCLUSIONS
  Medical selection is efficient to exclude blood donors at high risk of HIV transmission and to a lesser extent of HBV. However, current medical screening procedures do not allow us to exclude donors asymptomatic carriers of HCV and syphilis.
authors.affiliation: Centre national de transfusion sanguine, BP 5002, Dakar, Fann, Sénégal; Service d'hématologie, université Cheikh Anta Diop, BP 5002, Dakar, Fann, Sénégal.
authors.forename: M
authors.initials: M
authors.lastname: Seck
authors.affiliation: Centre national de transfusion sanguine, BP 5002, Dakar, Fann, Sénégal.
authors.forename: B
authors.initials: B
authors.lastname: Dièye
authors.affiliation: Centre national de transfusion sanguine, BP 5002, Dakar, Fann, Sénégal.
authors.forename: Y B
authors.initials: YB
authors.lastname: Guèye
authors.affiliation: Centre national de transfusion sanguine, BP 5002, Dakar, Fann, Sénégal; Service d'hématologie, université Cheikh Anta Diop, BP 5002, Dakar, Fann, Sénégal.
authors.forename: B F
authors.initials: BF
authors.lastname: Faye
authors.affiliation: Centre national de transfusion sanguine, BP 5002, Dakar, Fann, Sénégal.
authors.forename: A B
authors.initials: AB
authors.lastname: Senghor
authors.affiliation: Centre national de transfusion sanguine, BP 5002, Dakar, Fann, Sénégal.
authors.forename: S A
authors.initials: SA
authors.lastname: Toure
authors.affiliation: Centre national de transfusion sanguine, BP 5002, Dakar, Fann, Sénégal.
authors.forename: N
authors.initials: N
authors.lastname: Dieng
authors.affiliation: Laboratoire d'hématologie, hôpital Aristide le Dantec, Dakar, Sénégal; Service d'hématologie, université Cheikh Anta Diop, BP 5002, Dakar, Fann, Sénégal.
authors.forename: A
authors.initials: A
authors.lastname: Sall
authors.affiliation: Laboratoire d'hématologie, hôpital Aristide le Dantec, Dakar, Sénégal; Service d'hématologie, université Cheikh Anta Diop, BP 5002, Dakar, Fann, Sénégal.
authors.forename: A O
authors.initials: AO
authors.lastname: Toure
authors.affiliation: Centre national de transfusion sanguine, BP 5002, Dakar, Fann, Sénégal; Service d'hématologie, université Cheikh Anta Diop, BP 5002, Dakar, Fann, Sénégal.
authors.forename: T N
authors.initials: TN
authors.lastname: Dièye
authors.affiliation: Centre national de transfusion sanguine, BP 5002, Dakar, Fann, Sénégal; Service d'hématologie, université Cheikh Anta Diop, BP 5002, Dakar, Fann, Sénégal. Electronic address: saliou.diop@ucad.edu.sn.
authors.forename: S
authors.initials: S
authors.lastname: Diop
mesh_terms: D000293:Adolescent; D000328:Adult; D016470:Bacteremia / Q000175:diagnosis / Q000517:prevention & control / Q000635:transmission; D001782:Blood Donors; D058731:Blood Safety; D017848:Blood-Borne Pathogens; D003430:Cross-Sectional Studies; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D015397:Program Evaluation; D011446:Prospective Studies; D012675:Senegal / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D013587:Syphilis / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D065227:Transfusion Reaction; D014766:Viremia / Q000175:diagnosis / Q000517:prevention & control / Q000635:transmission; D055815:Young Adult
keywords: Blood donors; Donneurs de sang; HBV; HCV; HIV; Medical screening; Sélection médicale; VHB; VHC; VIH