title: Recent developments in the Raman and infrared investigations of amorphous pharmaceuticals and protein formulations: A review.
abstract: The success rate for drug discovery and the development of innovative therapeutic strategies are intimately related to the physical properties of the solid-state condensed matter, which have direct influence on the bioavailability of Active Pharmaceutical Ingredients. In order to transform a new molecule in efficient drug, the material is brought into an amorphous state using various manufacturing processes including freeze drying, spray drying, hot melt extrusion and loading in different delivery devices. The infrared and Raman spectroscopic analyses used for exploring disordered and amorphous states, for the monitoring of the drug physical stability in drug delivery systems are described in this review.
authors.affiliation: Université Lille Nord de France, F-59000 Lille, France; USTL UMET UMR, 8207F-59655 Villeneuve d'Ascq, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Hédoux
mesh_terms: D002626:Chemistry, Pharmaceutical; D003890:Desiccation; D004355:Drug Stability; D004364:Pharmaceutical Preparations; D011506:Proteins; D013059:Spectrum Analysis, Raman
chemical_list: D004364:Pharmaceutical Preparations; D011506:Proteins
keywords: Chemometrics; Drug delivery systems; Low-frequency Raman spectroscopy; Physical stability