title: Is There a Role for Desmopressin in Liver Transplantation? A Case Report.
abstract: Living donor liver transplantation reduces time and mortality on the waiting list. Bleeding is a serious complication; however, "overcorrection" of coagulopathy may lead to hepatic artery thrombosis. We report a case where desmopressin (DDAVP) was used in the management of persistent postreperfusion bleeding (44 red blood cell units transfused). After 1 dose of DDAVP, bleeding improved significantly and the recipient had an unremarkable recovery. DDAVP should be considered for persisting bleeding after correcting common coagulation abnormalities where complexity of the anastomosis may preclude the use of more aggressive procoagulant drugs in liver transplantation.
authors.affiliation: Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, Minnesota, United States.
authors.forename: M M
authors.initials: MM
authors.lastname: Gonzales
authors.affiliation: Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, Minnesota, United States.
authors.forename: D Z
authors.initials: DZ
authors.lastname: Valdes
authors.affiliation: Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, Minnesota, United States.
authors.forename: R
authors.initials: R
authors.lastname: Helmick
authors.affiliation: Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, Minnesota, United States.
authors.forename: T
authors.initials: T
authors.lastname: Taner
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States. Electronic address: Vasdev.Gurinder@mayo.edu.
authors.forename: G
authors.initials: G
authors.lastname: Vasdev
mesh_terms: D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000187:drug effects; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000209:etiology
chemical_list: D006490:Hemostatics; D003894:Deamino Arginine Vasopressin