title: Red-Light-Responsive Supramolecular Valves for Photocontrolled Drug Release from Mesoporous Nanoparticles.
abstract: Red-light-responsive supramolecular valves constructed by tetra-ortho-methoxy-substituted azobenzene (mAzo) and β-cyclodextrin (β-CD) were used to control drug release from mesoporous silica nanoparticles (MSNs). Doxorubicin (DOX) was used as a model drug and loaded into nanopores of mAzo modified MSNs. β-CD formed supramolecular valves with mAzo by host-guest interaction and closed the nanopores. Red light was able to open the supramolecular valves and induce DOX release even in deep tissue.
authors.affiliation: Max Planck Institute for Polymer Research , Ackermannweg 10, D-55128 Mainz, Germany.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Wang
authors.affiliation: Max Planck Institute for Polymer Research , Ackermannweg 10, D-55128 Mainz, Germany.
authors.forename: Si
authors.initials: S
authors.lastname: Wu
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D004339:Drug Compounding; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D008027:Light; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D058608:Nanopores / Q000648:ultrastructure; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D003692:Delayed-Action Preparations; D047392:beta-Cyclodextrins; D012822:Silicon Dioxide; D004317:Doxorubicin; C009850:azobenzene; C031215:betadex