title: Crescentic glomerulonephritis in children: a single centre experience.
abstract: BACKGROUND
  Crescentic glomerulonephritis (CsGN) is characterized by crescents in 50% or more of glomeruli and clinically by a sudden and progressive decline in renal function.
  
  
  METHODS
  We evaluated the etiology, clinical features, prognostic factors and long-term outcome of CsGN. Between January 2000 and December 2010, 45 children (26 girls, 19 boys) with biopsy-proven CsGN (>50% crescents) were investigated retrospectively.
  
  
  RESULTS
  The mean age of the patients was 130.86±33.77 months. The mean duration of symptoms prior to diagnosis was 26±12 days (4-40 days). Most of the children had hypertension (62.2%), macroscopic hematuria (73.3%), oligoanuria (44.4%), edema (51.1%) and purpuric rash (40%) at presentation. The final clinical status of the patients was complete remission (n=21), partial remission (n=5) or chronic kidney disease (n=19). Adverse outcomes were significantly associated with a long duration between the onset of symptoms and treatment (P=0.038), the presence of oligoanuria (P=0.006), a severe decreased glomerular filtration rate (GFR <30 mL/min/1.73m²) and the need for dialysis (P=0.003) on admission, the ratio of crescents (>75%) (P=0.03), and the ratio of fibrous crescents (P=0.015).
  
  
  CONCLUSIONS
  The outcome of CsGN in children continues to be poor, and it should be treated as a renal emergency.
authors.affiliation: Department of Pediatric Nephrology, Dr Sami Ulus Childrens and Maternity Hospital, Ankara, Turkey. saredr@gmail.com.|Department of Pathology, Sami Ulus Childrens and Maternity Hospital, Ankara, Turkey. saredr@gmail.com.
authors.forename: Sare Gülfem
authors.initials: SG
authors.lastname: Özlü
authors.affiliation: Department of Pediatric Nephrology, Dr Sami Ulus Childrens and Maternity Hospital, Ankara, Turkey.
authors.forename: Aysun
authors.initials: A
authors.lastname: Çaltık
authors.affiliation: Department of Pediatric Nephrology, Dr Sami Ulus Childrens and Maternity Hospital, Ankara, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Aydoğ
authors.affiliation: Department of Pediatric Nephrology, Dr Sami Ulus Childrens and Maternity Hospital, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bülbül
authors.affiliation: Department of Pediatric Nephrology, Dr Sami Ulus Childrens and Maternity Hospital, Ankara, Turkey.
authors.forename: Gülay
authors.initials: G
authors.lastname: Demircin
authors.affiliation: Department of Pediatric Nephrology, Dr Sami Ulus Childrens and Maternity Hospital, Ankara, Turkey.
authors.forename: Evrim
authors.initials: E
authors.lastname: Çakıcı
authors.affiliation: Department of Pathology, Sami Ulus Childrens and Maternity Hospital, Ankara, Turkey.
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Arda
authors.affiliation: Department of Pediatric Nephrology, Dr Sami Ulus Childrens and Maternity Hospital, Ankara, Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Öner
mesh_terms: D002648:Child; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors
keywords: glomerulonephritis; renal biopsy; renal failure