title: Long-Term Efficacy of Etanercept for Plaque-Type Psoriasis and Estimated Cost in Daily Clinical Practice.
abstract: BACKGROUND
  There are numerous clinical trials proving efficacy and safety profiles of etanercept. Newer studies, however, include patients with significant comorbidities, unstable psoriasis, or concomitant treatments.
  
  
  OBJECTIVE
  The objective of this study was to provide data on long-term response to etanercept and estimate the cost in daily practice.
  
  
  METHODS
  This is an observational retrospective study including patients with plaque-type psoriasis receiving etanercept 50 mg/wk for more than 6 months at the Dermatology Department of the University Hospital of La Coruña (Spain). Psoriasis severity was determined using the Psoriasis Area and Severity Index (PASI) at baseline and then at 12 weeks, 24 weeks, and annually until treatment discontinuation.
  
  
  RESULTS
  A total of 102 patients aged 24 to 78 years were included. Response rates of 58.8% and 66.3% for PASI 75 score (reduction of at least 75% in PASI score compared with baseline) were achieved after 12 and 24 weeks of treatment, respectively. Among patients who continued treatment, the PASI 75 score was maintained by 75.3% at 1 year, 82.5% at 2 years, and 88.2% at 3 years. The percentage of patients receiving other systemic treatments was 38.2%. Adverse effects were reported in 13.7%, all of them mild, except one case of urinary sepsis. The average cost per patient was €244.68 ± €45.27 per week and €34.95 ± €6.46 per day.
  
  
  CONCLUSIONS
  We provide data on long-term response to etanercept and its costs in a real-world setting. Response rates were higher than in some clinical trials, with progressive efficacy and not related to body mass index. Etanercept cost was comparable with that estimated in other studies. Combination with a conventional systemic agent can enhance efficacy without additional adverse events.
authors.affiliation: Department of Dermatology, University Hospital of La Coruña, La Coruña, Spain. Electronic address: rosaftorres@gmail.com.
authors.forename: Rosa
authors.initials: R
authors.lastname: María Fernández-Torres
authors.affiliation: Department of Dermatology, University Hospital of La Coruña, La Coruña, Spain.
authors.forename: Sabela
authors.initials: S
authors.lastname: Paradela
authors.affiliation: Department of Dermatology, University Hospital of La Coruña, La Coruña, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Fonseca
mesh_terms: D000328:Adult; D000368:Aged; D003365:Costs and Cost Analysis; D000068800:Etanercept / Q000009:adverse effects / Q000191:economics* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000191:economics* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013030:Spain
chemical_list: D007166:Immunosuppressive Agents; D000068800:Etanercept
keywords: aque-type psoriasis; cost; daily clinical practice; efficacy; etanercept