title: Dietary Restriction and Nutrient Balance in Aging.
abstract: Dietary regimens that favour reduced calorie intake delay aging and age-associated diseases. New evidences revealed that nutritional balance of dietary components without food restriction increases lifespan. Particular nutrients as several nitrogen sources, proteins, amino acid, and ammonium are implicated in life and healthspan regulation in different model organisms from yeast to mammals. Aging and dietary restriction interact through partially overlapping mechanisms in the activation of the conserved nutrient-signalling pathways, mainly the insulin/insulin-like growth factor (IIS) and the Target Of Rapamycin (TOR). The specific nutrients of dietary regimens, their balance, and how they interact with different genes and pathways are currently being uncovered. Taking into account that dietary regimes can largely influence overall human health and changes in risk factors such as cholesterol level and blood pressure, these new findings are of great importance to fully comprehend the interplay between diet and humans health.
authors.affiliation: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal ; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
authors.forename: Júlia
authors.identifier: 0000-0002-4035-0692
authors.initials: J
authors.lastname: Santos
authors.affiliation: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal ; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Leitão-Correia
authors.affiliation: Molecular and Environmental Biology Centre (CBMA), Department of Biology, University of Minho, 4710-057 Braga, Portugal.
authors.forename: Maria João
authors.identifier: 0000-0001-9424-4150
authors.initials: MJ
authors.lastname: Sousa
authors.affiliation: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal ; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
authors.forename: Cecília
authors.identifier: 0000-0003-1311-7884
authors.initials: C
authors.lastname: Leão
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000473:pathology; D001794:Blood Pressure; D031204:Caloric Restriction; D002784:Cholesterol / Q000378:metabolism; D004032:Diet; D004044:Dietary Proteins / Q000008:administration & dosage; D006801:Humans; D007328:Insulin / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D004044:Dietary Proteins; D007328:Insulin; D002784:Cholesterol; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases