title: High-Level Expression and Prognostic Significance of Matrix Metalloprotease-19 and Matrix Metalloprotease-20 in Human Pancreatic Ductal Adenocarcinoma.
abstract: Matrix metalloproteinase (MMP)-19 and MMP-20 are important members of the MMP family, and their roles in tumor survivorship and progression are continually reported. This work aimed to determine the expression and prognostic significance of MMP-19 and MMP-20 in pancreatic ductal adenocarcinoma (PDAC).
  
  
  
  Immunohistochemistry was used to investigate the levels of MMP-19 and MMP-20 expression in carcinoma tissues and paracancerous tissues from 102 PDAC patients.
  
  
  
  The MMP-19 and MMP-20 were, respectively, expressed in 71.6% (73/102) and 70.6% (72/102) of carcinoma tissues, and the expression was positively correlated (r = 0.643, P < 0.001). High-level expression of MMP-19 and MMP-20 was strongly correlated with aggressive clinicopathological characteristics. Kaplan-Meier analysis showed that high-level expression of MMP-19 and MMP-20 was significantly associated with decreased event-free survival (P < 0.001) and overall survival (P < 0.001). Multivariate analysis showed that high-level expression of MMP-19 could act as an independent predictive biomarker for poor event-free survival and overall survival.
  
  
  
  Levels of MMP-19 and MMP-20 expression are significantly increased in PDAC. High-level expression of MMP-19 and MMP-20 is closely correlated to progression and prognosis of PDAC, and these may be considered as promising markers for unfavorable prognoses.
authors.affiliation: From the Department of General Surgery, Affiliated Provincial Hospital of Anhui Medical University; and Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Hefei, People's Republic of China.
authors.forename: Lu-Lu
authors.initials: LL
authors.lastname: Zhai
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
authors.forename: Chong-Yang
authors.initials: CY
authors.lastname: Cai
authors.forename: Qiang
authors.initials: Q
authors.lastname: Huang
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Tang
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D053519:Matrix Metalloproteinase 20 / Q000096:biosynthesis*; D053505:Matrix Metalloproteinases, Secreted / Q000096:biosynthesis*; D008875:Middle Aged; D015999:Multivariate Analysis; D010179:Pancreas / Q000201:enzymology* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D053519:Matrix Metalloproteinase 20; D053505:Matrix Metalloproteinases, Secreted; C108362:matrix metalloproteinase 19