title: Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy.
abstract: Duchenne Muscular Dystrophy (DMD) is a fatal genetic muscle wasting disease with no current cure. A prominent, yet poorly treated feature of dystrophic muscle is the dysregulation of energy homeostasis which may be associated with intrinsic defects in key energy systems and promote muscle wasting. As such, supplementative nutriceuticals that target and augment the bioenergetical expansion of the metabolic pathways involved in cellular energy production have been widely investigated for their therapeutic efficacy in the treatment of DMD. We describe the metabolic nuances of dystrophin-deficient skeletal muscle and review the potential of various metabogenic and nutriceutical compounds to ameliorate the pathological and clinical progression of the disease.
authors.affiliation: Centre for Chronic Disease, College of Health &amp; Biomedicine, Victoria University, Melbourne 8001, Australia. emma.rybalka@vu.edu.au.|Institute of Sport, Exercise &amp; Healthy Living, Victoria University, Melbourne 8001, Australia. emma.rybalka@vu.edu.au.|Australian Institute of Musculoskeletal Science, Western Health, Melbourne 3021, Australia. emma.rybalka@vu.edu.au.
authors.forename: Emma
authors.initials: E
authors.lastname: Rybalka
authors.affiliation: Centre for Chronic Disease, College of Health &amp; Biomedicine, Victoria University, Melbourne 8001, Australia. cara.timpani@vu.edu.au.|Institute of Sport, Exercise &amp; Healthy Living, Victoria University, Melbourne 8001, Australia. cara.timpani@vu.edu.au.
authors.forename: Cara A
authors.initials: CA
authors.lastname: Timpani
authors.affiliation: Centre for Chronic Disease, College of Health &amp; Biomedicine, Victoria University, Melbourne 8001, Australia. christos.stathis@vu.edu.au.|Institute of Sport, Exercise &amp; Healthy Living, Victoria University, Melbourne 8001, Australia. christos.stathis@vu.edu.au.|Australian Institute of Musculoskeletal Science, Western Health, Melbourne 3021, Australia. christos.stathis@vu.edu.au.
authors.forename: Christos G
authors.initials: CG
authors.lastname: Stathis
authors.affiliation: Centre for Chronic Disease, College of Health &amp; Biomedicine, Victoria University, Melbourne 8001, Australia. alan.hayes@vu.edu.au.|Institute of Sport, Exercise &amp; Healthy Living, Victoria University, Melbourne 8001, Australia. alan.hayes@vu.edu.au.|Australian Institute of Musculoskeletal Science, Western Health, Melbourne 3021, Australia. alan.hayes@vu.edu.au.
authors.forename: Alan
authors.initials: A
authors.lastname: Hayes
authors.affiliation: Centre for Chronic Disease, College of Health &amp; Biomedicine, Victoria University, Melbourne 8001, Australia. matthew.cooke@vu.edu.au.|Institute of Sport, Exercise &amp; Healthy Living, Victoria University, Melbourne 8001, Australia. matthew.cooke@vu.edu.au.|Australian Institute of Musculoskeletal Science, Western Health, Melbourne 3021, Australia. matthew.cooke@vu.edu.au.
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Cooke
mesh_terms: D019587:Dietary Supplements; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D018482:Muscle, Skeletal / Q000473:pathology*; D009133:Muscular Atrophy / Q000178:diet therapy* / Q000209:etiology / Q000473:pathology; D020388:Muscular Dystrophy, Duchenne / Q000473:pathology*
keywords: Duchenne Muscular Dystrophy; dietary supplementation; metabolism; mitochondria; nutriceuticals