title: Recurrent skin infection associated with nasal carriage of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus closely related to the EMRSA-15 clone.
abstract: We report the case of a soldier with recurrent skin infection associated with nasal carriage of a Panton-Valentine leukocidin (PVL)-producing methicillin-susceptible Staphylococcus aureus (MSSA), closely related to the EMRSA-15 clone. MSSA isolates causing infection not requiring hospitalization usually go unnoticed; however, their typing may be useful to understand the global distribution of successful staphylococcal lineages related to epidemic clones. PVL-positive MSSA strains might serve as reservoirs from which virulent methicillin-resistant strains may evolve and spread.
authors.affiliation: Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, via Brecce Bianche, 60131 Ancona, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Vignaroli
authors.affiliation: Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, via Brecce Bianche, 60131 Ancona, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Di Sante
authors.affiliation: S.C. Microbiologia Clinica e Virologia, Azienda per l'Assistenza Sanitaria N.5 'Friuli Occidentale', Presidio Ospedaliero di Pordenone, Pordenone, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Stano
authors.affiliation: Dipartimento di Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, Ancona, Italy.
authors.forename: Pietro E
authors.initials: PE
authors.lastname: Varaldo
authors.affiliation: S.C. Microbiologia Clinica e Virologia, Azienda per l'Assistenza Sanitaria N.5 'Friuli Occidentale', Presidio Ospedaliero di Pordenone, Pordenone, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Camporese
mesh_terms: D000328:Adult; D001427:Bacterial Toxins / Q000235:genetics*; D002353:Carrier State / Q000382:microbiology*; D005098:Exotoxins / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007956:Leukocidins / Q000235:genetics*; D008297:Male; D008889:Military Personnel; D058889:Molecular Typing; D009666:Nose / Q000382:microbiology*; D012008:Recurrence; D013203:Staphylococcal Infections / Q000382:microbiology*; D013207:Staphylococcal Skin Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D037521:Virulence Factors
keywords: MSSA; Panton–Valentine leukocidin; clonal complex; nasal carriage; skin infection