title: Comparison of survival of adolescents and young adults with hematologic malignancies in Osaka, Japan.
abstract: The survival gap between adolescents and young adults (AYAs) with hematological malignancies persists in many countries. To determine to what extent it does in Japan, we investigated survival and treatment regimens in 211 Japanese AYAs (15-29 years) in the Osaka Cancer Registry diagnosed during 2001-2005 with hematological malignancies, and compared adolescents (15-19 years) with young adults (20-29 years). AYAs with acute lymphoblastic leukemia (ALL) had a poor 5-year survival (44%), particularly young adults (29% vs. 64% in adolescents, p = 0.01). Additional investigation for patients with ALL revealed that only 19% of young adults were treated with pediatric treatment regimens compared with 45% of adolescents (p = 0.05). Our data indicate that we need to focus on young adults with ALL and to consider establishing appropriate cancer care system and guidelines for them in Japan.
authors.affiliation: a Center for Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases , Osaka , Japan ;
authors.forename: Kayo
authors.initials: K
authors.lastname: Nakata-Yamada
authors.affiliation: b Department of Hematology/Oncology , Osaka Medical Center and Research Institute for Maternal and Child Health , Osaka , Japan ;
authors.forename: Masami
authors.initials: M
authors.lastname: Inoue
authors.affiliation: a Center for Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases , Osaka , Japan ;
authors.forename: Akiko
authors.initials: A
authors.lastname: Ioka
authors.affiliation: a Center for Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases , Osaka , Japan ;
authors.forename: Yuri
authors.initials: Y
authors.lastname: Ito
authors.affiliation: a Center for Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases , Osaka , Japan ;
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tabuchi
authors.affiliation: a Center for Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases , Osaka , Japan ;
authors.forename: Isao
authors.initials: I
authors.lastname: Miyashiro
authors.affiliation: c Department of Hematology/Oncology , Osaka Medical Center for Cancer and Cardiovascular Diseases , Osaka , Japan ;
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Masaie
authors.affiliation: c Department of Hematology/Oncology , Osaka Medical Center for Cancer and Cardiovascular Diseases , Osaka , Japan ;
authors.forename: Jun
authors.initials: J
authors.lastname: Ishikawa
authors.affiliation: d Department of Hematology , Graduate School of Medicine, Osaka City University , Osaka , Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hino
authors.affiliation: a Center for Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases , Osaka , Japan ;
authors.forename: Hideaki
authors.initials: H
authors.lastname: Tsukuma
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D005260:Female; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008297:Male; D011159:Population Surveillance; D011379:Prognosis; D016016:Proportional Hazards Models; D055815:Young Adult
keywords: Adolescents and young adults; hematological malignancies; leukemia; lymphoma; survival