title: Comparison of the Protective Effects of Melatonin and Silymarin Against Gentamicin-Induced Nephrotoxicity in Rats.
abstract: This study compared the possible protective effects of silymarin and melatonin against gentamicin (GEN)-induced nephrotoxicity in rats. Rats were allocated to 6 groups: Group I, control group; Groups II and III, administered with silymarin or melatonin; Group IV, injected with GEN; and Groups V and VI, administered with silymarin or melatonin, and then injected with GEN. Compared with the rats in the control group, all rats injected with GEN significantly presented elevated levels of serum creatinine and urea that was accompanied by an increase in relative kidney weight, increase in renal reactive oxygen species (ROS) and malondialdehyde (MDA) levels, and reduction in renal glutathione (GSH) level and superoxide dismutase (SOD) activity. Silymarin and melatonin pretreatment significantly lowered the elevated serum urea and creatinine concentration, kidney weight, and renal ROS and MDA levels. In addition, silymarin and melatonin significantly enhanced renal GSH level and SOD activity. This study indicates that silymarin and melatonin can attenuate renal injury in rats treated with GEN possibly by reducing the ROS level.
authors.affiliation: Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Habib
authors.initials: H
authors.lastname: Ghaznavi
authors.affiliation: Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Mehrzadi
authors.affiliation: Department of Pediatric Nephrology, AJA University of Medical Sciences, Tehran, Iran dr.dormanesh@yahoo.com.
authors.forename: Banafshe
authors.initials: B
authors.lastname: Dormanesh
authors.affiliation: Department of Pediatric Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Seyyed Mohammad Taghi Hosseini
authors.initials: SM
authors.lastname: Tabatabaei
authors.affiliation: Health Sciences Research Center, Department of Food and Nutrition, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Habib
authors.initials: H
authors.lastname: Vahedi
authors.affiliation: Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Azam
authors.initials: A
authors.lastname: Hosseinzadeh
authors.affiliation: Physiology Research Center (PRC), Iran University of Medical Sciences, Tehran, Iran.
authors.forename: HamidReza
authors.initials: H
authors.lastname: Pazoki-Toroudi
authors.affiliation: Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Rashidian
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D005839:Gentamicins / Q000633:toxicity*; D005978:Glutathione / Q000032:analysis; D007668:Kidney / Q000737:chemistry / Q000187:drug effects* / Q000201:enzymology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D010088:Oxidoreductases / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D012838:Silymarin / Q000494:pharmacology*; D014508:Urea / Q000097:blood
chemical_list: D000975:Antioxidants; D005839:Gentamicins; D012838:Silymarin; D014508:Urea; D003404:Creatinine; D010088:Oxidoreductases; D005978:Glutathione; D008550:Melatonin
keywords: antioxidants; kidney; lipid peroxidation; reactive oxygen species