title: In Vitro Capture of Small Ferrous Particles with a Magnetic Filtration Device Designed for Intravascular Use with Intraarterial Chemotherapy: Proof-of-Concept Study.
abstract: OBJECTIVE
  To establish that a magnetic device designed for intravascular use can bind small iron particles in physiologic flow models.
  
  
  METHODS
  Uncoated iron oxide particles 50-100 nm and 1-5 µm in size were tested in a water flow chamber over a period of 10 minutes without a magnet (ie, control) and with large and small prototype magnets. These same particles and 1-µm carboxylic acid-coated iron oxide beads were likewise tested in a serum flow chamber model without a magnet (ie, control) and with the small prototype magnet.
  
  
  RESULTS
  Particles were successfully captured from solution. Particle concentrations in solution decreased in all experiments (P < .05 vs matched control runs). At 10 minutes, concentrations were 98% (50-100-nm particles in water with a large magnet), 97% (50-100-nm particles in water with a small magnet), 99% (1-5-µm particles in water with a large magnet), 99% (1-5-µm particles in water with a small magnet), 95% (50-100-nm particles in serum with a small magnet), 92% (1-5-µm particles in serum with a small magnet), and 75% (1-µm coated beads in serum with a small magnet) lower compared with matched control runs.
  
  
  CONCLUSIONS
  This study demonstrates the concept of magnetic capture of small iron oxide particles in physiologic flow models by using a small wire-mounted magnetic filter designed for intravascular use.
authors.affiliation: Department of Radiology and Biomedical Imaging, San Francisco, California. Electronic address: marc.mabray@ucsf.edu.
authors.forename: Marc C
authors.initials: MC
authors.lastname: Mabray
authors.affiliation: Department of Radiology and Biomedical Imaging, San Francisco, California.
authors.forename: Prasheel
authors.initials: P
authors.lastname: Lillaney
authors.affiliation: Department of Radiology and Biomedical Imaging, San Francisco, California.
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Sze
authors.affiliation: Department of Radiology and Biomedical Imaging, San Francisco, California.
authors.forename: Aaron D
authors.initials: AD
authors.lastname: Losey
authors.affiliation: Department of Radiology and Biomedical Imaging, San Francisco, California.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Bioengineering, University of California, Berkeley, Berkeley, California.
authors.forename: Sravani
authors.initials: S
authors.lastname: Kondapavulur
authors.affiliation: Department of Bioengineering, University of California, Berkeley, Berkeley, California.
authors.forename: Derek
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Radiology and Biomedical Imaging, San Francisco, California.
authors.forename: Maythem
authors.initials: M
authors.lastname: Saeed
authors.affiliation: Department of Radiology and Biomedical Imaging, San Francisco, California.
authors.forename: Anand
authors.initials: A
authors.lastname: Patel
authors.affiliation: Department of Radiology and Biomedical Imaging, San Francisco, California.
authors.forename: Daniel
authors.initials: D
authors.lastname: Cooke
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California.
authors.forename: Young-Wook
authors.initials: YW
authors.lastname: Jun
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California.
authors.forename: Ivan
authors.initials: I
authors.lastname: El-Sayed
authors.affiliation: Department of Radiology and Biomedical Imaging, San Francisco, California.
authors.forename: Mark
authors.initials: M
authors.lastname: Wilson
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California.
authors.forename: Steven W
authors.initials: SW
authors.lastname: Hetts
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers; D004339:Drug Compounding; D004867:Equipment Design; D005290:Ferric Compounds / Q000737:chemistry*; D005296:Ferrous Compounds / Q000737:chemistry*; D005374:Filtration / Q000295:instrumentation*; D007269:Injections, Intra-Arterial; D059346:Magnets; D008422:Materials Testing; D008955:Models, Cardiovascular; D010316:Particle Size; D012039:Regional Blood Flow; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005290:Ferric Compounds; D005296:Ferrous Compounds; C000499:ferric oxide; C034236:ferrous oxide