title: [Multi-center comparative study of methylprednisolone and dexamethasone in treatment of all-frequency sudden hearing loss].
abstract: OBJECTIVE
  Through a prospective cohort study, to assess the clinical efficacy of methylprednisolone (MP) and dexamethasone (DXM) in treatment of all-frequency sudden hearing loss.
  
  
  METHODS
  A total of 76 cases of all-frequency sudden hearing loss were included in this study and divided into two groups. The MP group (n = 40) was treated with MP 40 mg qd, for 5 days, combined with conventional treatment. The DXM group (n = 36) was treated with DXM 10 mg qd, for 5 days, combined with conventional treatment. The total period of treatment was 14 days.
  
  
  RESULTS
  After the treatment for 14 days, in the MP group,17 cases were cured (42.5%), 7 cases were markedly improved (17.5%), 9 cases were effective (22.5%), and 7 cases were invalid (17.5%), the total effective rate was 82.5%. As for the patients in the DXM group, 13 cases were cured (36.1%), 6 cases were markedly improved (16.7%), 8 cases were effective (24.2%), and 9 cases were invalid (25%), the total effective rate was 75.0%. The pure tone audiometry in all-frequency was improved (31.5 ± 17.8) dB in the MP group, and (33.1 ± 24.2) dB in the DXM group. The speech recognition rate was improved (41.7 ± 29.8) %, and (42.0 ± 39.1) % in the DXM group. There were no significant differences between two groups.
  
  
  CONCLUSIONS
  There is no significant difference of therapeutic efficacy between the low-dose MP group and High-dose DXM group.
authors.affiliation: Department of Otorhinolaryngology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Jing
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Institute of Otorhinolaryngology, General Hospital of People's Liberation Army, Beijing 100853, China.
authors.forename: Dayong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
authors.forename: Zhaomin
authors.initials: Z
authors.lastname: Fan
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China.
authors.forename: Xiulan
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China.
authors.forename: Xinjia
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Institute of Otorhinolaryngology, General Hospital of People's Liberation Army, Beijing 100853, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Xi
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Institute of Otorhinolaryngology, General Hospital of People's Liberation Army, Beijing 100853, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology, Peking University People's Hospital, Beijing 100044, China; Email: yulish68@163.com.
authors.forename: Lisheng
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Institute of Otorhinolaryngology, General Hospital of People's Liberation Army, Beijing 100853, China; Email: wqcr@263.net.
authors.forename: Qiuju
authors.initials: Q
authors.lastname: Wang
mesh_terms: D001301:Audiometry, Pure-Tone; D003907:Dexamethasone / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000627:therapeutic use; D003639:Hearing Loss, Sudden / Q000188:drug therapy*; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use*; D011446:Prospective Studies; D013067:Speech Perception
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone; D008775:Methylprednisolone