title: [The effect of catalase on smoking related laryngeal squamous cell carcinoma].
abstract: OBJECTIVE
  Investigate the effect of oxidative stress on the occurrence and development of laryngeal squamous cell carcinoma associated with smoking, and the clinical diagnostic value of catalase on smoking related laryngeal squamous cell carcinoma.
  
  
  METHODS
  Collecting 119 smokers(including the smoking related laryngeal cancer group 68 cases, the control group 51 cases), the indexes of catalase (CAT), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH), nitric oxide (NO) in blood plasma and cancerous tissue in two groups were compared. The association between these oxidative stress indicators and the occurrence and severity of smoking related laryngeal squamous cell carcinoma was analysised by SPSS 17.0.
  
  
  RESULTS
  (1) Compared with control group, the smoke frequency and amount, CAT, MDA, GSH increased significantly in the smoking related laryngeal cancer group (P = 0.000; 0.000; 0.000; 0.000; 0.000); whereas SOD, NO decreased (P = 0.000; 0.000). (2) The lower the differentiation degree, the higher the serum CAT (P = 0.000) and the higher CAT, MDA, GSH of larynx tissue (P = 0.000; 0.000; 0.000), but the lower the serum NO (P = 0.000) and the lower SOD, NO of larynx tissue (P = 0.000; 0.000); The higher the clinical stage, the higher CAT of serum and larynx tissue and the higher GSH of larynx tissue (P = 0.000; 0.001), the lower NO of larynx tissue (P = 0.009). (3) The serum CAT, MDA were independent risk factors of smoking related laryngeal squamous cell carcinoma (OR = 1.060, 2.475; P < 0.01, P < 0.05).
  
  
  CONCLUSIONS
  Oxidative stress is the key factor of the occurrence of smoking related laryngeal squamous cell carcinoma, and the CAT can be used as the indicator of clinical diagnosis of smoking related laryngeal squamous cell carcinoma.
authors.forename: Yachao
authors.initials: Y
authors.lastname: Liu
authors.forename: Caifeng
authors.initials: C
authors.lastname: La
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Liu
authors.forename: Guogang
authors.initials: G
authors.lastname: Xu
authors.forename: Yantao
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000201:enzymology*; D002374:Catalase / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D006258:Head and Neck Neoplasms / Q000201:enzymology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000201:enzymology*; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D000077195:Squamous Cell Carcinoma of Head and Neck; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D009569:Nitric Oxide; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione