title: Imaging lung tissue oscillations using high-speed X-ray velocimetry.
abstract: This work utilized synchrotron imaging to achieve a regional assessment of the lung's response to imparted oscillations. The forced oscillation technique is increasingly being used in clinical and research settings for the measurement of lung function. During the forced oscillation technique, pressure oscillations are imparted to the lungs via the subjects' airway opening and the response is measured. This provides information about the mechanical properties of the airways and lung tissue. The quality of measurements is dependent upon the input signal penetrating uniformly throughout the lung. However, the penetration of these signals is not well understood. The development and use of a novel image-processing technique in conjunction with synchrotron-based imaging was able to regionally assess the lungs' response to input pressure oscillation signals in anaesthetized mice. The imaging-based technique was able to quantify both the power and distribution of lung tissue oscillations during forced oscillations of the lungs. It was observed that under forced oscillations the apices had limited lung tissue expansion relative to the base. This technique could be used to optimize input signals used for the forced oscillation technique or potentially as a diagnostic tool itself.
authors.affiliation: Department of Mechanical and Aerospace Engineering, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
authors.forename: Jordan
authors.initials: J
authors.lastname: Thurgood
authors.affiliation: Department of Mechanical and Aerospace Engineering, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
authors.forename: Stephen
authors.initials: S
authors.lastname: Dubsky
authors.affiliation: SPring-8/JASRI, Hyogo, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Uesugi
authors.affiliation: Department of Mechanical and Aerospace Engineering, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Curtis
authors.affiliation: 4Dx Pty Ltd, Howleys Road, Notting Hill, Victoria 3164, Australia.
authors.forename: Chaminda R
authors.initials: CR
authors.lastname: Samarage
authors.affiliation: Allergy Immunology and Respiratory Medicine, The Alfred Hospital and Department of Medicine, Monash University, Commercial Road, Melbourne, Victoria 3004, Australia.
authors.forename: Bruce
authors.initials: B
authors.lastname: Thompson
authors.affiliation: School of Medicine, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania 7000, Australia.
authors.forename: Graeme
authors.initials: G
authors.lastname: Zosky
authors.affiliation: Department of Mechanical and Aerospace Engineering, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
authors.forename: Andreas
authors.initials: A
authors.lastname: Fouras
mesh_terms: D000818:Animals; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011859:Radiography; D012212:Rheology / Q000379:methods*; D014965:X-Rays
keywords: forced oscillation technique; functional lung imaging; phase contrast X-ray imaging