title: Ischemic long-term-potentiation (iLTP): perspectives to set the threshold of neural plasticity toward therapy.
abstract: The precise role of neural plasticity under pathological conditions remains not well understood. It appears to be well accepted, however, that changes in the ability of neurons to express plasticity accompany neurological diseases. Here, we discuss recent experimental evidence, which suggests that synaptic plasticity induced by a pathological stimulus, i.e., ischemic long-term-potentiation (iLTP) of excitatory synapses, could play an important role for post-stroke recovery by influencing the post-lesional reorganization of surviving neuronal networks.
authors.affiliation: Department of Neurology, The J. Sagol Neuroscience Center, The Chaim Sheba Medical Center, Tel HaShomer, Israel ; Institute of Clinical Neuroanatomy, Neuroscience Center Frankfurt, Goethe-University Frankfurt, Frankfurt, Germany.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Lenz
authors.affiliation: Institute of Clinical Neuroanatomy, Neuroscience Center Frankfurt, Goethe-University Frankfurt, Frankfurt, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Vlachos
authors.affiliation: Department of Neurology, The J. Sagol Neuroscience Center, The Chaim Sheba Medical Center, Tel HaShomer, Israel ; Talpiot Medical Leadership Program, The Chaim Sheba Medical Center, Tel HaShomer, Israel.
authors.forename: Nicola
authors.identifier: 0000-0001-5041-2108
authors.initials: N
authors.lastname: Maggio
keywords: ischemic LTP (iLTP); neural homeostasis; neural repair; stroke; synaptic plasticity