title: Pregabalin Treatment of a Patient With Complex Regional Pain Syndrome.
abstract: BACKGROUND
  Complex regional pain syndrome (CRPS) is a painful and disabling neurovascular condition. There is no consensus on the etiopathogenesis or the treatment. We present a patient with CRPS type 1 accompanied by a psychiatric disorder to discuss the relationship between CRPS and psychiatric disease and to emphasize the response of this case to treatment with pregabalin.
  
  
  METHODS
  A 15-year-old girl presented with swelling, severe pain, edema, hyperesthesia, allodynia, and sweating changes in the left arm and was diagnosed as CRPS type 1. The presence of disturbed family relations was revealed on psychiatric examination, and a diagnosis of major depression was made. Her symptoms did not respond to selective serotonin reuptake inhibitors and noradrenergic and specific serotonergic antidepressives, gabapentin, or stellate ganglion blockage, but the patient's pain resolved with pregabalin. Symptom-oriented measures and psychiatric support enabled ongoing treatment. A social services evaluation led to her being placed in the care of social services to protect her from the chaotic and traumatic family life.
  
  
  CONCLUSIONS
  Detailed psycological and psychiatric evaluation is recommended in individuals with CRPS because psychiatric support and improvement of associated psychosocial concerns in addition to pregabalin seems to facilitate treatments in some patients.
authors.affiliation: Division of Child Neurology, Department of Pediatrics, Istanbul University Cerrahpaşa Medical Faculty, Istanbul, Turkey. Electronic address: sema.saltik@ctf.edu.tr.
authors.forename: Sema
authors.initials: S
authors.lastname: Saltık
authors.affiliation: Department of Child Neurology, Istanbul Medeniyet University Goztepe Research and Training Hospital, Istanbul, Turkey.
authors.forename: Hatice Gulhan
authors.initials: HG
authors.lastname: Sözen
authors.affiliation: Department of Psychology, Faculty of Economics, Administrative and Social Sciences, Hasan Kalyoncu University, Istanbul, Turkey.
authors.forename: Senem
authors.initials: S
authors.lastname: Basgul
authors.affiliation: Department of Child Neurology, Istanbul Medeniyet University Goztepe Research and Training Hospital, Istanbul, Turkey.
authors.forename: Elif Yuksel
authors.initials: EY
authors.lastname: Karatoprak
authors.affiliation: Department of Physical Therapy and Rehabilitation, Istanbul Medeniyet University Goztepe Research and Training Hospital, Istanbul, Turkey.
authors.forename: Afitap
authors.initials: A
authors.lastname: Içağasıoğlu
mesh_terms: D000293:Adolescent; D000700:Analgesics / Q000627:therapeutic use*; D020918:Complex Regional Pain Syndromes / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D003865:Major Depressive Disorder / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006225:Hand / Q000473:pathology; D006801:Humans; D000069583:Pregabalin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D000069583:Pregabalin
keywords: complex regional pain syndrome; depression; pain; pregabalin