title: A pH-Driven and photoresponsive nanocarrier: Remotely-controlled by near-infrared light for stepwise antitumor treatment.
abstract: The hollow gold nanospheres (HAuNS) have shown medicinal promise due to their inert and nontoxic properties with unique photothermal therapy capabilities. In this study, the electrostatic approach was employed to successfully absorb Chlorin e6 (Ce6) simultaneously with the pH (low) insertion peptide (pHLIP) onto surface of HAuNS, forming HAuNS-pHLIP-Ce6 with desirable pH-driven and NIR light-stimulated controlled therapeutical effect. The HAuNS-pHLIP-Ce6 experienced hyperthermia within 5 min of laser exposure, which marked the photothermal therapy (PTT) and deduced the agents release due to the reduction of electrostatic interaction. The improved strategy facilitated a stepwise photoresponsive system capable of active accumulation and retention effects, photothermal ablation of tumor cells, release of photosensitizers (PS), and subsequently photodynamic therapy (PDT) in a single light irradiation session. The smart delivery system had been proved with multi-functionalities via conjugated targeting ligand and PS. The external absorption of patient tailored medication combinations was also possible with this treatment platform.
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
authors.forename: Meng
authors.initials: M
authors.lastname: Yu
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Guo
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
authors.forename: Jinping
authors.initials: J
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
authors.forename: Fengping
authors.initials: F
authors.lastname: Tan
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China. Electronic address: linan19850115@163.com.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
mesh_terms: D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D002735:Chlorophyllides; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000528:radiation effects*; D004058:Diffusion / Q000528:radiation effects; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry / Q000528:radiation effects; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D011166:Porphyrins / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D002735:Chlorophyllides; D003692:Delayed-Action Preparations; D053769:Nanocapsules; D017319:Photosensitizing Agents; D011166:Porphyrins; C062985:phytochlorin; D006046:Gold
keywords: PTT/PDT effect; Photoresponsive; Single light trigger; Stepwise therapy; pH-driven