title: Serum adiponectin is independently associated with the metabolic syndrome in Hong Kong, Chinese women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate the association of serum adiponectin level with the metabolic syndrome in Chinese women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  This was a cross-sectional study carried out in Hong Kong Chinese women with PCOS at a university-affiliated tertiary hospital between January 2010 and January 2011. Clinical and biochemical parameters of the women were analysed. Prediction of the metabolic syndrome was determined by receiver-operator characteristic (ROC) curves, univariate and multivariate logistic regression analyses.
  
  
  RESULTS
  A total of 116 women diagnosed to have PCOS were analysed. The area under the ROC curve of adiponectin for the prediction of metabolic syndrome was 0.820, 95% confidence interval (CI) 0.737-0.886. Univariate binary logistic regression showed that testosterone, sex hormone-binding globulin (SHBG), free androgen index (FAI), waist circumference, body mass index (BMI), quantitative insulin-sensitivity check index (QUICKI), homeostasis model assessment of insulin resistance (HOMA-IR) and adiponectin were significantly associated with the metabolic syndrome. On multivariate logistic regression analysis, adiponectin (p =  0.020), HOMA-IR, age (p =  0.011) and BMI (p =  0.019) were independently associated with the metabolic syndrome, but not FAI (p =  0.256).
  
  
  CONCLUSIONS
  Serum adiponectin is independently associated with the metabolic syndrome in Chinese women with PCOS. Further longitudinal follow-up studies are needed to determine whether serum adiponectin adds to the prediction of long-term cardiometabolic morbidity conferred by age, BMI and measures of insulin resistance.
authors.affiliation: a Department of Obstetrics and Gynaecology , The University of Hong Kong, Queen Mary Hospital , Hong Kong .
authors.forename: Jennifer Ka Yee
authors.initials: JK
authors.lastname: Ko
authors.affiliation: a Department of Obstetrics and Gynaecology , The University of Hong Kong, Queen Mary Hospital , Hong Kong .
authors.forename: Hang Wun Raymond
authors.initials: HW
authors.lastname: Li
authors.affiliation: b Department of Medicine , The University of Hong Kong, Queen Mary Hospital , Hong Kong , and.
authors.forename: Karen Siu Ling
authors.initials: KS
authors.lastname: Lam
authors.affiliation: b Department of Medicine , The University of Hong Kong, Queen Mary Hospital , Hong Kong , and.|c Department of Pathology and Clinical Biochemistry , The University of Hong Kong, Queen Mary Hospital , Hong Kong.
authors.forename: Sidney
authors.initials: S
authors.lastname: Tam
authors.affiliation: a Department of Obstetrics and Gynaecology , The University of Hong Kong, Queen Mary Hospital , Hong Kong .
authors.forename: Vivian Chi Yan
authors.initials: VC
authors.lastname: Lee
authors.affiliation: a Department of Obstetrics and Gynaecology , The University of Hong Kong, Queen Mary Hospital , Hong Kong .
authors.forename: Tracy Wing Yee
authors.initials: TW
authors.lastname: Yeung
authors.affiliation: a Department of Obstetrics and Gynaecology , The University of Hong Kong, Queen Mary Hospital , Hong Kong .
authors.forename: Pak Chung
authors.initials: PC
authors.lastname: Ho
authors.affiliation: a Department of Obstetrics and Gynaecology , The University of Hong Kong, Queen Mary Hospital , Hong Kong .
authors.forename: Ernest Hung Yu
authors.initials: EH
authors.lastname: Ng
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006723:Hong Kong; D006801:Humans; D007328:Insulin / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D009765:Obesity / Q000097:blood* / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D013739:Testosterone / Q000097:blood; D055105:Waist Circumference
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone
keywords: Adiponectin; metabolic syndrome; polycystic ovary syndrome