title: Relationship of Endothelial Cell-Specific Molecule 1 Level in Stress Hyperglycemia Patients With Acute ST-Segment Elevation Myocardial Infarction: A Pilot Study.
abstract: Endothelial cell-specific molecule 1 ([ESM-1], endocan) is a new biomarker of endothelial dysfunction, which may be involved in the pathogenesis of atherosclerosis and stress hyperglycemia in patients with acute ST-segment elevation myocardial infarction (STEMI). Therefore, we investigated serum ESM-1 levels in patients with stress hyperglycemia having STEMI; 105 patients with STEMI and 33 individuals as a control group were included in the study. The patients were followed up for 3 months and major adverse cardiac events (MACEs) were recorded. Serum ESM-1 level was significantly higher in patients with stress hyperglycemia patients having STEMI (P < .05). In these patients, serum ESM-1 levels correlated positively with glucose levels (r = .21, P < .05). Multiple factor logistic regression analysis showed that serum ESM-1 levels >1.01 ng/mL (odds ratio 3.01, 95% confidence interval 1.05-8.64, P < .05) were an independent predictor of MACEs. Our findings suggest that ESM-1 is a novel biomarker overexpressed in patients with stress hyperglycemia having STEMI, admission glucose levels are associated with ESM-1 levels, and ESM-1 is an independent predictor of MACEs. An ESM-1 level >1.01 ng/mL is likely to predict a greater risk of MACEs.
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People's Republic of China.
authors.forename: Chongrong
authors.initials: C
authors.lastname: Qiu
authors.affiliation: Medical College of Jiangsu University, Zhenjiang, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Sui
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wei
authors.affiliation: Medical College of Jiangsu University, Zhenjiang, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People's Republic of China Institute of Cardiovascular Disease Research, Xuzhou City, Jiangsu Province, People's Republic of China fuqiang@medmail.com.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D016017:Odds Ratio; D010343:Patient Admission; D010865:Pilot Projects; D011446:Prospective Studies; D011509:Proteoglycans / Q000097:blood*; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D013312:Stress, Physiological; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans
keywords: acute ST-segment elevation myocardial infarction; endocan; endothelial cell–specific molecule 1; major adverse cardiac events; stress hyperglycemia