title: Effect of exogenous hydrogen sulfide on gastric acid secretion.
abstract: OBJECTIVE
  H2 S is an important gasotransmitter in the gastrointestinal tract. The aim of the present study was to investigate the effect of exogenous H2 S on gastric acid secretion.
  
  
  METHODS
  Male Wistar rats were randomly divided into physiological saline (PS) group, sodium hydrosulfide (NaHS; 50, 100, and 150 µmol/kg body weight) group, glibenclamide + NaHS group, and SQ22536 + NaHS group. PH of gastric juice before injection and after injection were determined by a PH meter.
  
  
  RESULTS
  The results showed that NaHS, an exogenous H2 S donor, injected into the enterocoelia significantly reduced the PH of gastric juice, the same volume of PS administered similarly did not change PH of gastric juice, the promotional effect of NaHS on gastric acid secretion could be abolished by glibenclamide, an ATP-sensitive potassium channel K(ATP) blocker SQ22536, an inhibitor of adenyl cyclase.
  
  
  CONCLUSIONS
  The data from these experiments suggest that exogenous H2 S promoted gastric acid secretion, which may occur via K(ATP) channels and activate AC-cAMP pathway.
authors.affiliation: College of Life Science, Qi Lu Normal University, Jinan, China.
authors.forename: Hongzhao
authors.initials: H
authors.lastname: Sun
authors.affiliation: College of Life Science, Qi Lu Normal University, Jinan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Life Science, Qi Lu Normal University, Jinan, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Shi
authors.affiliation: College of Life Science, Qi Lu Normal University, Jinan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: College of Life Science, Qi Lu Normal University, Jinan, China.
authors.forename: Guiyan
authors.initials: G
authors.lastname: Shi
authors.affiliation: College of Life Science, Qi Lu Normal University, Jinan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Life Science, Qi Lu Normal University, Jinan, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Guo
authors.affiliation: College of Life Science, Qi Lu Normal University, Jinan, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Huang
authors.affiliation: College of Life Science, Qi Lu Normal University, Jinan, China.
authors.forename: Yuning
authors.initials: Y
authors.lastname: Ren
authors.affiliation: College of Life Science, Qi Lu Normal University, Jinan, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Zheng
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D005744:Gastric Acid / Q000378:metabolism*; D005905:Glyburide / Q000494:pharmacology; D006862:Hydrogen Sulfide / Q000494:pharmacology*; D054086:KATP Channels / Q000502:physiology; D008297:Male; D017208:Rats, Wistar; D013268:Stimulation, Chemical; D013440:Sulfides / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D054086:KATP Channels; D013440:Sulfides; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; C025451:sodium bisulfide; D005905:Glyburide; D006862:Hydrogen Sulfide
keywords: ATP-sensitive potassium channel; cAMP; gastric acid secretion; hydrogen sulfide