title: Gastroretentive extended release of metformin from methacrylamide-g-gellan and tamarind seed gum composite matrix.
abstract: Formulation of a gastroretentive extended release tablet of metformin based on polymethacrylamide-g-gellan (Pmaa-g-GG)-tamarind seed gum (TSG) composite matrix is the main purpose of this study. Tablets were prepared employing wet granulation method taking amount of Pmaa-g-GG, TSG and NaHCO3 (SBC, buoyancy contributor) as independent formulation variables. The tablets were then evaluated for in vitro drug release, buoyancy, ex vivo mucoadhesion, swelling and surface morphology. Compatibility between drug and excipients was checked by DSC, FTIR and XRD analysis. Buoyancy-lag-time, mucoadhesive strength, % drug release and release-rate constant were statistically analyzed using Design-Expert software (version 9.0.4.1) and the formulation was then numerically optimized to obtain USP-reference release profile. The optimized formulation showed excellent buoyancy over a 10h period with buoyancy lag time of 2.76min, significant mucoadhesion and drug release over a period of 10h with f2=71.58. Kinetic modeling unveiled anomalous non-Fickian transport based drug release mechanism.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
authors.forename: Rosy
authors.initials: R
authors.lastname: Priyadarshini
authors.affiliation: BCDA College of Pharmacy and Technology, 78, Jessore Road (S), Hridaypur, Kolkata 700127, India. Electronic address: nandi_gouranga@yahoo.co.in.
authors.forename: Gouranga
authors.initials: G
authors.lastname: Nandi
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
authors.forename: Abhijit
authors.initials: A
authors.lastname: Changder
authors.affiliation: BCDA College of Pharmacy and Technology, 78, Jessore Road (S), Hridaypur, Kolkata 700127, India.
authors.forename: Sailee
authors.initials: S
authors.lastname: Chowdhury
authors.affiliation: BCDA College of Pharmacy and Technology, 78, Jessore Road (S), Hridaypur, Kolkata 700127, India.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Chakraborty
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
authors.forename: Lakshmi Kanta
authors.initials: LK
authors.lastname: Ghosh
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000818:Animals; D003692:Delayed-Action Preparations / Q000737:chemistry*; D065546:Drug Liberation; D005079:Excipients / Q000737:chemistry; D006041:Goats; D008687:Metformin / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*; D029861:Tamarindus / Q000737:chemistry*
chemical_list: D000178:Acrylamides; D003692:Delayed-Action Preparations; D005079:Excipients; D011135:Polysaccharides, Bacterial; C048288:gellan gum; D008687:Metformin; C045985:methacrylamide
keywords: Composite-matrix; Gastroretentive; Metformin; Polymethacrylamide-g-gellan; Tamarind seed gum