title: Novel targeted therapeutics for mantle cell lymphoma--what's on the horizon?
abstract: Major advances have significantly improved the outcome of mantle cell lymphoma (MCL). Incorporation of rituximab to CHOP regimen, the adoption of high dose cytarabine with frontline autologous stem cell transplantation in young patients, maintenance rituximab or bortezomib based chemotherapy in elderly patients, improved the disease outcome. Bortezomib, lenalidomide, temsirolimus and ibrutinib have proven their efficacy and are approved for the use in refractory or relapsed MCL patients. Several other molecules are currently being evaluated such as cyclin dependent kinase 4/6 (CDK4/6), phosphoinositide 3-kinase (PI3K), B cell lymphoma-2 (BCL2) and Poly ADP-ribose polymerase (PARP) inhibitors. Unfortunately, we don't have specific biomarkers that could reveal which of the underlying pathways or genetic alterations are mostly involved in each individual case of MCL. Efforts should be done in this field aiming to an optimal personalized therapy.
authors.affiliation: a Service d'hématologie, Département de Médecine , Institut Gustave Roussy , Villejuif , France.
authors.forename: Layal
authors.initials: L
authors.lastname: El Halabi
authors.affiliation: a Service d'hématologie, Département de Médecine , Institut Gustave Roussy , Villejuif , France.
authors.forename: David
authors.initials: D
authors.lastname: Ghez
authors.affiliation: a Service d'hématologie, Département de Médecine , Institut Gustave Roussy , Villejuif , France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Ribrag
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects; D004260:DNA Repair / Q000187:drug effects; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D058990:Molecular Targeted Therapy / Q000379:methods; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents
keywords: DNA damage response; Mantle cell lymphoma; apoptosis; cell cycle; chemotherapy; signaling pathways; targeted therapy