title: Autoimmune Neutropenia as a Cause of Periodontal Disease in Preschool Children.
abstract: In autoimmune neutropenia, autoantibodies attack neutrophils resulting in their destruction or alteration of their function. Since neutrophils have important immunologic functions, aberrations in their homeostasis lead to increased susceptibility to diseases, such as periodontitis. Periodontitis as a manifestation of neutropenia can affect adults and children. In this paper, we describe the treatment of periodontal disease in a 2-year-old female with autoimmune neutropenia. The importance of an interdisciplinary approach, frequent recalls, and meticulous mechanical therapy in stabilizing her periodontal condition, despite ongoing systemic infections is emphasized.
authors.affiliation: From Penn Dental Medicine,the University of Pennsylvania, Philadelphia, , USA.
authors.forename: Evlambia
authors.initials: E
authors.lastname: Hajishengallis
authors.affiliation: From Penn Dental Medicine,the University of Pennsylvania, Philadelphia, , USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Rashewsky
authors.affiliation: From Penn Dental Medicine,the University of Pennsylvania, Philadelphia, , USA.
authors.forename: Cyelee
authors.initials: C
authors.lastname: Kulkarni
authors.affiliation: From Penn Dental Medicine,the University of Pennsylvania, Philadelphia, , USA.
authors.forename: Panagiota
authors.initials: P
authors.lastname: Stathopoulou
mesh_terms: D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000276:immunology*; D002675:Child, Preschool; D002710:Chlorhexidine / Q000627:therapeutic use; D003777:Dental Prophylaxis / Q000379:methods; D005260:Female; D005884:Gingival Hemorrhage / Q000276:immunology; D005885:Gingival Hyperplasia / Q000276:immunology; D005891:Gingivitis / Q000276:immunology; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D009503:Neutropenia / Q000276:immunology*; D009910:Oral Hygiene / Q000193:education; D010518:Periodontitis / Q000276:immunology*
chemical_list: D000891:Anti-Infective Agents, Local; D016179:Granulocyte Colony-Stimulating Factor; D002710:Chlorhexidine
keywords: autoimmune neutropenia; children; periodontal disease