title: Autologous cord blood transplantation for metastatic neuroblastoma.
abstract: Auto-SCT is a common approach for metastatic neuroblastoma with the intention to rescue hematopoiesis after megadose chemotherapy. PBSC or BM is the usual stem cell source for auto-SCT. Auto-CBT for neuroblastoma has very rarely been performed. Currently, case reports are available for two patients only. We performed 13 auto-SCTs for high-risk neuroblastoma from 2007 to 2013, including four cases of metastatic neuroblastoma aged 11-64 months treated with auto-CBT. All four patients had partial or CR to upfront treatments before auto-CBT. Nucleated cell dose and CD34+ cell dose infused were 2.8-8.7 × 10(7) /kg and 0.36-3.9 × 10(5) /kg, respectively. Post-thawed viability was 57-76%. Neutrophil engraftment (>0.5 × 10(9) /L) occurred at 15-33 days, while platelet engraftment occurred at 31-43 days (>20 × 10(9) /L) and 33-65 days (>50 × 10(9) /L) post-transplant, respectively. There was no severe acute or chronic complication. Three patients survived for 1.9-7.7 yr without evidence of recurrence. One patient relapsed at 16 months post-transplant and died of progressive disease. Cord blood may be a feasible alternative stem cell source for auto-SCT in patients with stage 4 neuroblastoma, and outcomes may be improved compared to autologous PBSC or BM transplants.
authors.affiliation: Department of Pediatric Intensive Care Unit, Children's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Botao
authors.initials: B
authors.lastname: Ning
authors.affiliation: Department of Paediatrics & Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
authors.forename: Daniel Ka-Leung
authors.initials: DK
authors.lastname: Cheuk
authors.affiliation: Department of Paediatrics & Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
authors.forename: Alan Kwok-Shing
authors.initials: AK
authors.lastname: Chiang
authors.affiliation: Department of Paediatrics & Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
authors.forename: Pamela Pui-Wah
authors.initials: PP
authors.lastname: Lee
authors.affiliation: Department of Paediatrics & Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
authors.forename: Shau-Yin
authors.initials: SY
authors.lastname: Ha
authors.affiliation: Department of Paediatrics & Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
authors.forename: Godfrey Chi-Fung
authors.initials: GC
authors.lastname: Chan
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D001771:Blood Banks; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D002470:Cell Survival; D002648:Child; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation; D018450:Disease Progression; D004358:Drug Therapy / Q000379:methods; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D006801:Humans; D007223:Infant; D008297:Male; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009447:Neuroblastoma / Q000473:pathology / Q000628:therapy*; D009504:Neutrophils / Q000166:cytology; D012008:Recurrence; D012189:Retrospective Studies; D014182:Transplantation, Autologous
chemical_list: D018952:Antigens, CD34
keywords: autologous; cord blood; neuroblastoma; transplantation