title: Old and new pathogenic Nakaseomyces species: epidemiology, biology, identification, pathogenicity and antifungal resistance.
abstract: During the previous decades, as the number of immunocompromised patients, the average age of Western populations and the widespread use of indwelling medical devices have increased concomitantly, so has the incidence of infections caused by Candida species. Candida albicans remains the most frequently isolated agent of candidiasis. However, C. glabrata now accounts for a substantial part of clinical isolates, ranking number two among the etiologic agents of either superficial or invasive candidiasis in North America and Europe. Along with C. glabrata and belonging to the Nakaseomyces clade, two new species, C. nivariensis and C bracarensis have recently been described as emerging pathogens. This review provides information on the current state of knowledge on the epidemiology, biology, identification, pathogenicity and antifungal resistance of C. glabrata, C. nivariensis and C. bracarensis.
authors.affiliation: Laboratoire de Parasitologie-Mycologie, University Hospital Bicêtre, APHP, 94275 Le Kremlin-Bicêtre, France CNRS UMR 8621, Génétique Quantitative et Évolution, Univ Paris-Sud, Le Moulon, 91190 Gif-sur-Yvette, France adela.angoulvant@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Angoulvant
authors.affiliation: Service de Parasitologie-Mycologie, University Hospital St Antoine, APHP, 75012 Paris, France Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Univ Paris 06 UPMC, Sorbonne Universités, CR7, 75013 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Guitard
authors.affiliation: Service de Parasitologie-Mycologie, University Hospital St Antoine, APHP, 75012 Paris, France Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Univ Paris 06 UPMC, Sorbonne Universités, CR7, 75013 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Hennequin
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification* / Q000502:physiology; D002177:Candidiasis / Q000453:epidemiology* / Q000382:microbiology*; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000382:microbiology; D025141:Drug Resistance, Fungal; D014943:Global Health; D006801:Humans; D037521:Virulence Factors / Q000235:genetics
chemical_list: D000935:Antifungal Agents; D037521:Virulence Factors
keywords: C. bracarensis: epidemiology; C. glabrata; C. nivariensis; biology; pathogenicity