title: Preferential binding of 4-hydroxynonenal to lysine residues in specific parasite proteins in plakortin-treated Plasmodium falciparum-parasitized red blood cells.
abstract: The data show the frequencies by which the amino acid residues lysine, histidine and cysteine of six proteins of the malaria parasite Plasmodium falciparum are post-translationally modified by the lipoperoxydation endproduct 4-hydroxynonenal after challenging the parasitized red blood cell with plakortin. Plakortin is an antimalarial endoperoxide whose molecular anti-parasitic effect is described in Skorokhod et al. (2015) [1]. Plakortin did not elicit hemoglobin leakage from host red blood cells and did not oxidize reduced glutathione.
authors.affiliation: Department of Oncology, University of Torino, Via Santena 5bis, 10126 Torino, Italy.
authors.forename: Evelin
authors.initials: E
authors.lastname: Schwarzer
authors.affiliation: Department of Oncology, University of Torino, Via Santena 5bis, 10126 Torino, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Gallo
authors.affiliation: Department of Oncology, University of Torino, Via Santena 5bis, 10126 Torino, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Valente
authors.affiliation: Department of Oncology, University of Torino, Via Santena 5bis, 10126 Torino, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Ulliers
authors.affiliation: Department of Pharmacy, University of Napoli "Federico II", Via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Orazio
authors.initials: O
authors.lastname: Taglialatela-Scafati
authors.affiliation: Department of Oncology, University of Torino, Via Santena 5bis, 10126 Torino, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Arese
authors.affiliation: Department of Oncology, University of Torino, Via Santena 5bis, 10126 Torino, Italy.
authors.forename: Oleksii A
authors.initials: OA
authors.lastname: Skorokhod
keywords: 4-hydroxynonenal; Plasmodium falciparum; antimalarial drug; endoperoxide; plakortin; post-translational modifications; red blood cell