title: Function and mechanism of neurotensin (NTS) and its receptor 1 (NTSR1) in occurrence and development of tumors.
abstract: As a neuropeptide, neurotensin (NTS) is widely expressed in central and peripheral nervous system, which is mainly mediated byneurotensin receptor1 (NTSR1) to activate the related downstream signaling pathways. After summarized the function and mechanism of NTS/NTSR1 in various malignant tumors, we found that NTS/NTSR1 played essential roles during tumor initiation and development. NTS/NTSR1 regulates tumor initiation, proliferation, apoptosis, metastasis and differentiation mainly through three pathways, including IP3/Ca2+ /PKC/MAPKs pathway, MMPs/EGFR/MAPKs (PI3K/Akt) pathway, or Rho-GTPsaes and non-receptor tyrosine kinase pathway. Besides, NTS/NTSR1 is also regulated by some upstream pathways and some traditional Chinese medicine preparations and traditional Chinese medicine therapies. In this article, we summarized the function of NTS/NTSR1 and its mechanisms, and discussed the prospective in its application to clinical diagnosis and drugs targeting.
authors.forename: Huan-rong
authors.initials: HR
authors.lastname: Hu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Dong
authors.forename: Liang
authors.initials: L
authors.lastname: Yi
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: He
authors.forename: Yan-li
authors.initials: YL
authors.lastname: Zhang
authors.forename: Ya-ling
authors.initials: YL
authors.lastname: Liu
authors.forename: Hong-juan
authors.initials: HJ
authors.lastname: Cui
mesh_terms: D000818:Animals; D066246:ErbB Receptors / Q000502:physiology; D006801:Humans; D008516:Medicine, Chinese Traditional; D009369:Neoplasms / Q000209:etiology*; D009496:Neurotensin / Q000737:chemistry / Q000502:physiology*; D018028:Receptors, Neurotensin / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D020742:rhoA GTP-Binding Protein / Q000502:physiology
chemical_list: D018028:Receptors, Neurotensin; C114036:neurotensin type 1 receptor; D009496:Neurotensin; D066246:ErbB Receptors; D020742:rhoA GTP-Binding Protein