title: Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities.
abstract: Preeclampsia is a pregnancy-related disease afflicting 3-7% of pregnancies worldwide and leads to maternal and infant morbidity and mortality. The disease is of placental origin and is commonly described as a disease of two stages. A variety of preeclampsia animal models have been proposed, but all of them have limitations in fully recapitulating the human disease. Based on the research question at hand, different or multiple models might be suitable. Multiple animal models in combination with in vitro or ex vivo studies on human placenta together offer a synergistic platform to further our understanding of the etiology of preeclampsia and potential therapeutic interventions. The described animal models of preeclampsia divide into four categories (i) spontaneous, (ii) surgically induced, (iii) pharmacologically/substance induced, and (iv) transgenic. This review aims at providing an inventory of novel models addressing etiology of the disease and or therapeutic/intervention opportunities.
authors.affiliation: Obstetrics and Gynecology, Institution of Clinical Sciences, Lund University, Lund, Sweden.
authors.forename: Lena
authors.initials: L
authors.lastname: Erlandsson
authors.affiliation: Obstetrics and Gynecology, Institution of Clinical Sciences, Lund University, Lund, Sweden.
authors.forename: Åsa
authors.initials: Å
authors.lastname: Nääv
authors.affiliation: School of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
authors.forename: Annemarie
authors.initials: A
authors.lastname: Hennessy
authors.affiliation: INSERM U1016, CNRS UMR8104, Faculté de Médecine, Institut Cochin, Paris, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Vaiman
authors.affiliation: Infection Medicine, Institution of Clinical Sciences, Lund University, Lund, Sweden.
authors.forename: Magnus
authors.initials: M
authors.lastname: Gram
authors.affiliation: Infection Medicine, Institution of Clinical Sciences, Lund University, Lund, Sweden.
authors.forename: Bo
authors.initials: B
authors.lastname: Åkerström
authors.affiliation: Obstetrics and Gynecology, Institution of Clinical Sciences, Lund University, Lund, Sweden.
authors.forename: Stefan R
authors.initials: SR
authors.lastname: Hansson
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000209:etiology / Q000276:immunology / Q000628:therapy; D011247:Pregnancy
keywords: Hypertension; placenta; proteinuria; treatment opportunities; two-stage model; α1-microglobulin