title: [The efficacy and safety of subconjunctival triamcinolone acetonide injections in treatment of uveitic macular edema].
abstract: OBJECTIVE
  To observe the efficacy and safety of subconjunctival triamcinolone acetonide injections in the treatment of uveitic macular edema (UME).
  
  
  METHODS
  A retrospective case series study. The clinical data of uveitis patients with macular edema were collected and analyzed at Peking Union Medical College Hospital from July 2009 to June 2014 with a minimum follow-up period of 6 months. The main outcome was central macular thickness (CMT) measured by optical coherence tomography at the 1st and the 3rd month after injection. The secondary outcomes included best corrected visual acuity (BCVA) at the 1st and the 3rd month, recurrence rate and intraocular pressure (IOP) within 6 months after injection.
  
  
  RESULTS
  Thirty two patients (37 eyes) were included in the study. At the 1st month after the first injection, 24 of the 37 eyes (64.9%) showed an obvious reduction of CMT (at least 20%), among them 15 eyes (40.5%) showed a total resolution. The mean CMT decreased from (498.9 ± 211.9) µm at baseline to (392.4 ± 232.3) µm (t = -4.070, P < 0.01). The BCVA improved in 20 eyes (54.1%) and 15 eyes (40.5%) gained more than 0.2 log MAR unit. The mean BCVA increased from logMAR, 0.45 ± 0.29 at baseline to logMAR, 0.33 ± 0.30 (t = -4.835, P < 0.01). No statistically significant difference was found in mean CMT or BCVA in 23 eyes between the 1st and the 3rd month after injection. These eyes didn't receive any additional medications for improvement of the condition. Seven eyes (30.4%, 7/23) got a second injection because of relapse within 6 months after the first injection and the efficacy was good. The elevation of IOP over 21 mmHg (1 mmHg = 0.133 kPa) were observed in 9 eyes and 3 eyes after the first and the second injection respectively. All of them were well controlled by either topical IOP lowering drugs or removal of the subconjunctival TA deposition.
  
  
  CONCLUSIONS
  Subconjunctival injection of triamcinolone acetonide is an effective and safe method for uveitic macular edema.
authors.affiliation: Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
authors.forename: Xinshu
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
authors.forename: Chan
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China; Email: meifen_zhang@hotmail.com.
authors.forename: Meifen
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects; D003228:Conjunctiva; D006801:Humans; D056965:Injections, Intraocular / Q000379:methods; D007429:Intraocular Pressure / Q000187:drug effects; D008266:Macula Lutea / Q000473:pathology; D008269:Macular Edema / Q000188:drug therapy* / Q000209:etiology; D012008:Recurrence; D019233:Retreatment; D012189:Retrospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000009:adverse effects; D014605:Uveitis / Q000150:complications*; D014792:Visual Acuity; D014822:Vitreous Body
chemical_list: D000893:Anti-Inflammatory Agents; D014222:Triamcinolone Acetonide