title: [Analysis of clinicopathological features and prognosis in patients with advanced gastric cancer in different locations].
abstract: OBJECTIVE
  To investigate the differences of clinicopathological features and prognosis in patients with advanced gastric cancer in different locations after radical gastrectomy, and to provide optimized therapies.
  
  
  METHODS
  Clinicopathological data of 421 patients with advanced gastric cancer undergoing radical gastrectomy in our department from January to December 2011 were analyzed retrospectively. Patients were divided into 3 groups according to cancer locations, including 48 cases of upper gastric cancer, 74 cases of middle gastric cancer and 299 cases of lower gastric cancer. Clinicopathological features and prognosis were compared among groups.
  
  
  RESULTS
  There were significant differences among 3 groups in lesion size(P=0.001), subtypes(P=0.033), pT classification(P=0.010), TNM staging(P=0.019) and lymph node metastasis (P=0.000). Ratio of lesion size >5 cm, and T4, N3, stage III( patients was significantly higher in upper gastric cancer group as compared to middle and lower group (all P<0.05). The survival curves showed that the general prognosis of upper gastric cancer group was worse than that of middle and lower gastric cancer group (P<0.05), while no significant difference was found between middle and lower gastric cancer group (P=0.027). Multivariate analysis revealed that depth of invasion (P=0.034, HR=1.918) was independent prognostic factor of advanced upper gastric cancer, lymph node metastasis (P=0.022, HR=1.406) was independent prognostic factor of advanced middle gastric cancer, and depth of invasion (P=0.022, HR=1.359) and lymph node metastasis (P=0.000, HR=1.519) were independent prognostic factors of advanced lower gastric cancer.
  
  
  CONCLUSIONS
  As compared to advanced middle and lower gastric cancer, advanced upper gastric cancer possesses bigger cancer lesion, deeper depth of invasion, easier metastasis of lymph nodes, later TNM staging, and worse prognosis.
authors.affiliation: Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China. XYW801@163.com.
authors.forename: Wenpeng
authors.initials: W
authors.lastname: Wang
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Xue
authors.forename: Chunyang
authors.initials: C
authors.lastname: Zhuo
authors.forename: Sen
authors.initials: S
authors.lastname: Li
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Li
authors.forename: Long
authors.initials: L
authors.lastname: Cheng
mesh_terms: D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms