title: miR-506 inhibits the proliferation and invasion by targeting IGF2BP1 in glioblastoma.
abstract: Increasing evidence has indicated that microRNAs (miRNAs) play an essential role in cancers. Deregulation of miR-506 was reported in several cancers. However, the expression and function of miR-506 in glioblastoma remain unclear. Our data showed that the level of miR-506 was downregulated in glioblastoma tissues and cell lines. Overexpression of miR-506 repressed cell growth, blocked G1/S transition, and suppressed cell invasion in glioblastoma cell. Moreover, IGF2BP1 was a direct target of miR-506 in glioblastoma cells. Knockdown of IGF2BP1 recapitulated the anti-proliferative and anti-invasive effects of miR-506, whereas IGF2BP1 overexpression antagonized the tumor-suppressive function of miR-506. Our data showed that miRNA-506 played a tumor suppressor gene role in human glioblastoma by regulating IGF2BP1 gene and might be a new therapeutic target of human glioblastoma.
authors.affiliation: Department of Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China.
authors.forename: Ranran
authors.initials: R
authors.lastname: Sun
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China.
authors.forename: Tongwen
authors.initials: T
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China.
authors.forename: Xianzhi
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
keywords: Glioblastoma; IGF2BP1; miR-506; miRNA