title: Vitamin D Level is Associated with Increased Left Ventricular Mass and Arterial Stiffness in Older Patients with Impaired Renal Function.
abstract: BACKGROUND Impaired renal function is common among older patients. Deficiency of vitamin D is a frequent phenomenon among patients with impaired renal function, who are likely to develop cardiovascular diseases. This study aimed to explore the association of 25 (OH) D levels with left ventricular mass and arterial stiffness in older patients with impaired renal function. MATERIAL AND METHODS Based on their admission estimate glomerular filtration rate (eGFR), 273 inpatients (≥65 years) were allocated into a normal eGFR group (≥60 ml/min) and an impaired eGFR group (<60 ml/min). The 25 (OH) D levels were measured and the left ventricular mass index (LVMI) was estimated. Pulse wave velocity (PWV) was used to explore arterial stiffness. RESULTS The 25 (OH) D levels of patients in the impaired eGFR group were significantly lower than in the normal eGFR group [(11.92±6.01) μg/L vs. (18.14±8.07) μg/L, p<0.05). LVMI and PWV were both significantly higher in the impaired eGFR group than in the normal eGFR group [(104.89±33.50) g/m2 vs. (92.95±18.95) g/m2, P<0.05; (15.99±3.10) m/s vs. (13.62±2.90) m/s, P<0.05]. After adjusting for age, sex, eGFR, cardiovascular risk factors, serum calcium, and iPTH levels, the inverse association between LVMI and 25 (OH) D, PWV, and 25 (OH) D were statistically significant. CONCLUSIONS Vitamin D level is lower in older patients with impaired renal function. Lower vitamin D levels were correlated with higher left ventricular mass and increased arterial stiffness in older patients.
authors.affiliation: Department of Geriatrics, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (mainland).
authors.forename: Jing
authors.initials: J
authors.lastname: Chang
authors.affiliation: Department of Heart Ultersound, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (mainland).
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Ye
authors.affiliation: Department of Geriatrics, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (mainland).
authors.forename: Yuan-Ping
authors.initials: YP
authors.lastname: Hou
authors.affiliation: Department of Geriatrics, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (mainland).
authors.forename: Jin-Ling
authors.initials: JL
authors.lastname: Wu
authors.affiliation: Department of Geriatrics, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (mainland).
authors.forename: Sheng-Li
authors.initials: SL
authors.lastname: Li
authors.affiliation: Department of Geriatrics, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (mainland).
authors.forename: Qian-Mei
authors.initials: QM
authors.lastname: Sun
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005919:Glomerular Filtration Rate; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D009929:Organ Size; D059289:Vascular Stiffness; D014807:Vitamin D / Q000097:blood*
chemical_list: D014807:Vitamin D