title: [Overview of patents on targeted genome editing technologies and their implications for innovation and entrepreneurship education in universities].
abstract: Zinc finger nuclease, transcription activator-like effector nuclease, and clustered regularly interspaced short palindromic repeats/Cas9 nuclease are important targeted genome editing technologies. They have great significance in scientific research and applications on aspects of functional genomics research, species improvement, disease prevention and gene therapy. There are past or ongoing disputes over ownership of the intellectual property behind every technology. In this review, we summarize the patents on these three targeted genome editing technologies in order to provide some reference for developing genome editing technologies with self-owned intellectual property rights and some implications for current innovation and entrepreneurship education in universities.
authors.affiliation: 1. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in the Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei 400715, China; 2. School of Biological Science and Technology, University of Jinan, Jinan 250022, China;
authors.forename: Xiang-yu
authors.initials: XY
authors.lastname: Fan
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in the Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei 400715, China.
authors.forename: Yan-ping
authors.initials: YP
authors.lastname: Lin
authors.affiliation: Institute of Modern Biopharmaceuticals, School of Pharmaceutical Sciences, Southwest University, Beibei 400715, China.
authors.forename: Guo-jian
authors.initials: GJ
authors.lastname: Liao
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in the Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei 400715, China.
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Xie
mesh_terms: D000818:Animals; D064113:CRISPR-Cas Systems; D004720:Endonucleases / Q000191:economics / Q000235:genetics / Q000378:metabolism; D016520:Entrepreneurship / Q000191:economics / Q000331:legislation & jurisprudence; D005823:Genetics / Q000191:economics / Q000193:education* / Q000331:legislation & jurisprudence*; D016678:Genome; D006801:Humans; D010330:Patents as Topic; D014495:Universities
chemical_list: D004720:Endonucleases