title: Live Long and Prosper for Antigen Cross-Presentation.
abstract: Even though proteolytic antigen fragments are displayed for cross-presentation, rapid proteolysis of endocytosed antigens inhibits this process. In this issue of Immunity, Alloatti et al. (2015) describe how maturing dendritic cells keep phagosomes and lysosomes apart to ensure extended antigen life that leads to prosperous cross-presentation.
authors.affiliation: Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland. Electronic address: christian.muenz@uzh.ch.
authors.forename: Christian
authors.initials: C
authors.lastname: Münz
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D045142:Cross-Priming / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D051197:Toll-Like Receptor 4 / Q000276:immunology*
chemical_list: D051197:Toll-Like Receptor 4