title: Use of a bioartificial dermal regeneration template for skin restoration in combat casualty injuries.
abstract: Military personnel who survive combat injuries frequently have large soft tissue wounds complicated by concomitant injuries and contamination. These devastating wounds present a therapeutic challenge to not only restore the protective skin barrier but also to preserve tendon and muscle excursion, provide protective padding around nerves and restore adequate joint motion. Accordingly, regenerative medicine modalities that can accomplish these goals are of great interest. The use of bioartificial dermal regeneration templates (DRT), such as Integra DRT (Integra Lifesciences Corporation, Plainsboro, NJ, USA), in the management of complex soft tissue injuries has an important role in the reconstruction of war wounds. These DRTs provide initial wound coverage and help establish a well-vascularized wound bed suitable for definitive soft tissue coverage.
authors.affiliation: Department of Orthopaedic Surgery, Walter Reed National Military Medical Center, 8901 Wisconsin Ave., Bethesda, MD 20889 USA.
authors.forename: Jonathan G
authors.initials: JG
authors.lastname: Seavey
authors.affiliation: Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
authors.forename: Zachary A
authors.initials: ZA
authors.lastname: Masters
authors.affiliation: Department of Orthopaedic Surgery, Walter Reed National Military Medical Center, 8901 Wisconsin Ave., Bethesda, MD 20889 USA.
authors.forename: George C
authors.initials: GC
authors.lastname: Balazs
authors.affiliation: Department of Orthopaedic Surgery, Walter Reed National Military Medical Center, 8901 Wisconsin Ave., Bethesda, MD 20889 USA.|Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
authors.forename: Scott M
authors.initials: SM
authors.lastname: Tintle
authors.affiliation: Department of General Surgery, Walter Reed National Military Medical Center, 8901 Wisconsin Ave., Bethesda, MD 20889, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Sabino
authors.affiliation: Department of Orthopaedic Surgery, Walter Reed National Military Medical Center, 8901 Wisconsin Ave., Bethesda, MD 20889 USA.|Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Fleming
authors.affiliation: Department of Plastic Surgery, The Ohio State University Wexner Medical Center, 915 Olentangy River Road, Ste 2100, Columbus, OH 43212, USA.
authors.forename: Ian L
authors.initials: IL
authors.lastname: Valerio
mesh_terms: D000328:Adult; D003646:Debridement; D020405:Dermis / Q000502:physiology*; D005260:Female; D006230:Hand Injuries / Q000628:therapy; D006801:Humans; D007869:Leg Injuries / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012038:Regeneration; D016038:Skin Transplantation; D017768:Skin, Artificial; D007507:Therapeutic Irrigation; D000067398:War-Related Injuries / Q000628:therapy*; D014945:Wound Healing; D055815:Young Adult
keywords: amputation; bioartificial dermal regeneration template; bioartificial dermal substitute; engineered dermis; integra; polytrauma wound management; soft tissue coverage