title: Association of four new candidate genetic variants with Parkinson's disease in a Han Chinese population.
abstract: Large-scale meta-analysis of genome-wide association data has identified six new risk loci (SIPA1L2, INPP5F, MIR4697, GCH1, VPS13C, and DDRGK1) for Parkinson's disease (PD). However, the characteristics of those loci in a Han Chinese population from mainland China are unknown. We examined genetic associations of VPS13C rs2414739, MIR4697 rs329648, GCH1 rs11158026, and SIPA1L2 rs10797576 with PD susceptibility in a Han Chinese population of 1028 sporadic PD patients and 1109 healthy controls. All subjects were genotyped for these loci using the Sequenom iPLEX Assay. We also conducted further stratified analysis according to age at onset and compared the clinical characteristics between minor allele carriers and non-carriers for each locus. However, we did not observe any significant difference in genotype distribution between PD patients and controls for the four loci, even after being stratified by age at onset. Besides, minor allele carriers cannot be distinguished from non-carriers based on their clinical features. Our findings first demonstrated that VPS13C rs2414739, MIR4697 rs329648, GCH1 rs11158026, and SIPA1L2 rs10797576 do not confer a significant risk for PD in Chinese population. Additional replication studies in other populations and functional studies are warranted to better validate the role of the four new loci in PD risk.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Sichuan, P.R. China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Sichuan, P.R. China.
authors.forename: Lan
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Sichuan, P.R. China.
authors.forename: Nan-Nan
authors.initials: NN
authors.lastname: Li
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Sichuan, P.R. China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Yu
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Sichuan, P.R. China.
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Sun
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Sichuan, P.R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Peng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
keywords: GCH1; MIR4697; Parkinson's disease; SIPA1L2; SNPs; VPS13C