title: Element Mapping in Organic Samples Utilizing a Benchtop X-Ray Fluorescence Emission Tomography (XFET) System.
abstract: X-ray fluorescence computed tomography (XFCT) is an emerging imaging modality that maps the three-dimensional distribution of elements, generally metals, inex vivospecimens and potentially in living animals and humans. Building on our previous synchrotron-based work, we experimentally explored the use of abenchtopX-ray fluorescence computed tomography system for mapping trace-metal ions in biological samples. This system utilizes a scanning pencil-beam to stimulate the object and then relies on a detection system, with single or multiple slit apertures placed in front of position-sensitive X-ray detectors, to collect the fluorescence X-rays and to form 3-D elemental map without the need for tomographic imaging reconstruction. The technique was used to generate images of the elemental distributions of a triple-tube phantom and an osmium-stained zebrafish.
authors.affiliation: Nuclear, Plasma, and Radiological Engineering, University of Illinois at Urbana-Champaign, IL 61801 USA.
authors.forename: A
authors.initials: A
authors.lastname: Groll
authors.affiliation: Nuclear, Plasma, and Radiological Engineering, University of Illinois at Urbana-Champaign, IL 61801 USA.
authors.forename: J
authors.initials: J
authors.lastname: George
authors.affiliation: Department of Radiology, University of Chicago, IL 60637 USA, telephone: 773-702-6975.
authors.forename: P
authors.initials: P
authors.lastname: Vargas
authors.affiliation: Department of Radiology, University of Chicago, IL 60637 USA, telephone: 773-702-6975.
authors.forename: P J
authors.initials: PJ
authors.lastname: La Rivière
authors.affiliation: Nuclear, Plasma, and Radiological Engineering, University of Illinois at Urbana-Champaign, IL 61801 USA, telephone: 217-333-7710.
authors.forename: L J
authors.initials: LJ
authors.lastname: Meng