title: Use of an Ex Vivo Porcine Mucosal Model to Study Superantigen Penetration.
abstract: In vitro perfusion studies are frequently used to determine the penetration of compounds through skin and mucosa. Porcine tissue has been shown to be an excellent model for human tissue in terms of structure, function, and reactivity. We describe the use of porcine tissue ex-vivo in a continuous flow perfusion system to study the behavior of superantigens in this model.
authors.affiliation: Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA, 52242, USA. christopher-squier@uiowa.edu.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Squier
authors.affiliation: Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA, 52242, USA.
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Mantz
mesh_terms: D000818:Animals; D002463:Cell Membrane Permeability; D004195:Disease Models, Animal; D005260:Female; D009061:Mouth Mucosa / Q000166:cytology / Q000378:metabolism; D009092:Mucous Membrane / Q000166:cytology / Q000378:metabolism*; D012867:Skin / Q000166:cytology / Q000378:metabolism; D018089:Superantigens / Q000276:immunology / Q000378:metabolism*; D013552:Swine; D014621:Vagina / Q000166:cytology / Q000378:metabolism
chemical_list: D018089:Superantigens
keywords: Ex-vivo porcine model; Mucosa; Pathogenic microorganisms; Perfusion cells; Permeability; Permeability barrier; Superantigens