title: Nonthyroidal illnesses syndrome in full-term newborns with sepsis.
abstract: OBJECTIVE
  To assess hormonal changes in nonthyroidal illness syndrome (NTIS) in full-term newborns (NT) with sepsis.
  
  
  METHODS
  We included 28 NT with sepsis divided into 2 groups according to the time of normalization of serum and clinical indicators of infection: group A(A), 16 NT with improvement in up to 8 days; and group B(B), 12 NT improvement after 8 days. Among the 28 NT, 15 NT progressed to septic shock, with 5 NT group A and 10 NT in group B. NT were excluded when they showed severe sepsis and asphyxia, and congenital malformations, as well as those whose mothers had thyroid disease and IUGR.
  
  
  RESULTS
  17 NT (60.7%) presented NTIS. Low T3 was observed in NTIS in 10 NT (58.8%), and low T4 and T3 in 5 NT (29.5%), all of them with septic shock. Two NT showed mixed changes (11.7%). After sepsis was cured, there was no hormonal change, except in 3 NT. Administration of dopamine, furosemide, and corticosteroids did not affect the results.
  
  
  CONCLUSIONS
  This study indicates that nonthyroidal illness syndrome may be transiently present during sepsis in full-term newborns, especially in cases of prolonged sepsis. Low T3 can occur without changes in reverse T3 (different from adults), and low T4 and T3 occur mainly in patients with septic shock.
authors.affiliation: Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Maria Helena Baptista Nunes da
authors.initials: MH
authors.lastname: Silva
authors.affiliation: Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Maria Cristina Korbage de
authors.initials: MC
authors.lastname: Araujo
authors.affiliation: Departamento de Pediatria, FMUSP, São Paulo, SP, Brasil.
authors.forename: Edna Maria de Albuquerque
authors.initials: EM
authors.lastname: Diniz
authors.affiliation: Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Maria Esther Jurfest Rivero
authors.initials: ME
authors.lastname: Ceccon
authors.affiliation: Departamento de Pediatria, FMUSP, São Paulo, SP, Brasil.
authors.forename: Werther Brunow de
authors.initials: WB
authors.lastname: Carvalho
mesh_terms: D018450:Disease Progression; D005067:Euthyroid Sick Syndromes / Q000097:blood / Q000150:complications*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018805:Sepsis / Q000150:complications; D012772:Shock, Septic / Q000097:blood / Q000150:complications*; D047929:Term Birth; D013974:Thyroxine / Q000097:blood; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013974:Thyroxine