title: IL-18 and Cutaneous Inflammatory Diseases.
abstract: Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.
authors.affiliation: Department of Dermatology, Seoul St Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul 137-701, Korea. ejee@catholic.ac.kr.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Life Science, Sookmyung Women's University, Seoul 140-742, Korea. cdhkor@sookmyung.ac.kr.
authors.forename: Dae Ho
authors.initials: DH
authors.lastname: Cho
authors.affiliation: Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, the Catholic University of Korea, 62 Yeouido-dong, Yeongdeungpo-gu, Seoul 150-713, Korea. hjpark@catholic.ac.kr.
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Park
mesh_terms: D000818:Animals; D006086:Graft vs Host Disease / Q000276:immunology / Q000378:metabolism; D006801:Humans; D056747:Immunomodulation; D018836:Inflammation Mediators / Q000502:physiology; D020382:Interleukin-18 / Q000502:physiology*; D015398:Signal Transduction; D012871:Skin Diseases / Q000276:immunology / Q000378:metabolism*
chemical_list: D018836:Inflammation Mediators; D020382:Interleukin-18
keywords: IL-18; alopecia areata; atopic dermatitis; contact dermatitis; drug eruption; fibrosis; graft-versus-host disease; lupus erythematosus; psoriasis; skin disease; skin tumor; urticaria