title: Type 2 Diabetes and Hearing Impairment.
abstract: Hearing impairment (HI) and type 2 diabetes are both highly prevalent disabling conditions. Type 2 diabetes has been modestly associated with a higher likelihood of HI in many, but not all, population-based studies, with stronger associations found in studies that included younger age groups. Pathophysiologic studies suggest that persons with diabetes are predisposed to HI in the higher frequencies. Proposed mechanisms underlying the association between diabetes and HI include the combined contributions of hyperglycemia and oxidative stress to cochlear microangiopathy and auditory neuropathy. In this review, we highlight recent population-based studies of type 2 diabetes and HI and examine evidence for diabetes-induced pathophysiologic changes that may result in damage to the auditory system.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Medical Center, 450 Clarkson Avenue, Mail Stop 43, Brooklyn, NY, 11203, USA. Elizabeth.Helzner@downstate.edu.
authors.forename: Elizabeth Purchase
authors.initials: EP
authors.lastname: Helzner
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Contrera
mesh_terms: D000375:Aging; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology*; D034381:Hearing Loss / Q000150:complications* / Q000453:epidemiology*; D006801:Humans; D015201:Meta-Analysis as Topic; D018384:Oxidative Stress; D015995:Prevalence
keywords: Diabetes; Epidemiology; Hearing; Presbycusis