title: Concise Total Synthesis of Dehaloperophoramidine.
abstract: Perophoramidine, dehaloperophoramidine, and communesin F are structurally related alkaloids having intriguing polycyclic structures. A strategy for the synthesis of dehaloperophoramidine has been developed. In this synthesis all skeletal atoms and all functional groups required to reach the target molecule are incorporated early in the sequence. This approach led to the discovery of two novel substrate-specific domino processes, one encompassing four steps and the other comprising five steps, thus resulting in an eight-step synthesis of dehaloperophoramidine.
authors.affiliation: Centre for Analysis and Synthesis, Department of Chemistry, Lund University, 22100, Lund, Sweden.
authors.forename: Kirill
authors.initials: K
authors.lastname: Popov
authors.affiliation: Centre for Analysis and Synthesis, Department of Chemistry, Lund University, 22100, Lund, Sweden.
authors.forename: Anita
authors.initials: A
authors.lastname: Hoang
authors.affiliation: Centre for Analysis and Synthesis, Department of Chemistry, Lund University, 22100, Lund, Sweden. peter.somfai@chem.lu.se.|Institute of Technology, University of Tartu, Nooruse 1, 50411, Tartu, Estonia. peter.somfai@chem.lu.se.
authors.forename: Peter
authors.identifier: http://orcid.org/0000-0001-9416-1283
authors.initials: P
authors.lastname: Somfai
mesh_terms: D045744:Cell Line, Tumor; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis*; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis*
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; D006846:Hydrocarbons, Halogenated; C472225:perophoramidine
keywords: alkaloids; domino reactions; heterocycles; natural products; total synthesis