title: Synthesis of 2,3,5,6-tetrafluoro-pyridine derivatives from reaction of pentafluoropyridine with malononitrile, piperazine and tetrazole-5-thiol.
abstract: Some pentafluoropyridine derivatives have been synthesized by the reaction of pentafluoropyridine with appropriate C, S and N-nucleophile such as malononitrile, 1-methyl-tetrazole-5-thiol and piperazine. These reactions provided 4-substituted 2,3,5,6-tetrafluoropyridine derivatives in good yields. All the compounds were characterized using (1)H, (13)C and (19)F-NMR spectroscopy and X-ray crystallography.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran.
authors.forename: Khalil
authors.initials: K
authors.lastname: Beyki
authors.affiliation: Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Haydari
authors.affiliation: Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran.
authors.forename: Malek Taher
authors.initials: MT
authors.lastname: Maghsoodlou
keywords: 19F-NMR; Heterocycle; Nucleophilic Substitution; Pentafluoropyridine; Synthesis