title: NUP214-ABL1 fusion defines a rare subtype of B-cell precursor acute lymphoblastic leukemia that could benefit from tyrosine kinase inhibitors.
authors.affiliation: CHU Lille, Biology and Pathology Center, Laboratory of Hematology, Lille, France INSERM UMR-S 1172, Cancer Research Institute, Lille, France nicolas.duployez@chru-lille.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Duployez
authors.affiliation: CHU Lille, Biology and Pathology Center, Laboratory of Hematology, Lille, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Grzych
authors.affiliation: CHU Lille, Biology and Pathology Center, Laboratory of Hematology, Lille, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Ducourneau
authors.affiliation: CHU Lille, Jeanne de Flandre Hospital, Pediatric Hematology Department, Lille, France.
authors.forename: Martin
authors.initials: M
authors.lastname: Alarcon Fuentes
authors.affiliation: CHU Lille, Biology and Pathology Center, Laboratory of Hematology, Lille, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Grardel
authors.affiliation: CHU Lille, Biology and Pathology Center, Laboratory of Hematology, Lille, France INSERM UMR-S 1172, Cancer Research Institute, Lille, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Boyer
authors.affiliation: CHU Lille, Jeanne de Flandre Hospital, Pediatric Hematology Department, Lille, France.
authors.forename: Wadih
authors.initials: W
authors.lastname: Abou Chahla
authors.affiliation: CHU Lille, Jeanne de Flandre Hospital, Pediatric Hematology Department, Lille, France.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Bruno
authors.affiliation: CHU Lille, Jeanne de Flandre Hospital, Pediatric Hematology Department, Lille, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Nelken
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Saint Louis Hospital, Laboratory of Hematology, Paris, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Clappier
authors.affiliation: CHU Lille, Biology and Pathology Center, Laboratory of Hematology, Lille, France INSERM UMR-S 1172, Cancer Research Institute, Lille, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Preudhomme
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D016026:Bone Marrow Transplantation; D005260:Female; D015870:Gene Expression; D006801:Humans; D028861:Nuclear Pore Complex Proteins / Q000235:genetics* / Q000378:metabolism; D015514:Oncogene Proteins, Fusion; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D016315:Proto-Oncogene Proteins c-abl / Q000235:genetics* / Q000378:metabolism; D012008:Recurrence; D012074:Remission Induction; D014185:Transplantation, Isogeneic; D017211:Treatment Failure
chemical_list: C085914:NUP214 protein, human; D028861:Nuclear Pore Complex Proteins; D015514:Oncogene Proteins, Fusion; D047428:Protein Kinase Inhibitors; D016315:Proto-Oncogene Proteins c-abl
keywords: B-cell precursor acute lymphoblastic leukemia; BCR-ABL1-like; adolescents; tyrosine kinase inhibitors