title: Localization of collagen modifying enzymes on fibroblastic reticular cells and follicular dendritic cells in non-neoplastic and neoplastic lymphoid tissues.
abstract: The aim of this study was to evaluate the localization of collagen modifying enzymes (CMEs) on fibroblastic reticular cells (FRCs) and follicular dendritic cells (FDCs) in non-neoplastic lymphoid tissues and various malignant lymphomas. The expression of prolyl 4-hydroxylase 1 (P4H1), lysyl hydroxylase 3 (LH3), and protein disulfide isomerase (PDI) was frequently observed on FRCs and FDCs in the germinal center (GC), except for the mantle zone. The expression of CMEs was lower in most lymphomas than in their respective postulated normal counterparts. The ratio of transglutaminase II(+) FRCs/CD35(+) FDCs was also lower in follicular lymphomas (FL) than in other lymphomas. The mRNAs of some CMEs (P4H1, prolyl 4-hydroxylase 3, LH3, and heat shock protein 47) were confirmed in almost all lymphomas. These results indicate that lymphoma cell proliferation suppresses/decreases the number of CMEs expressing FRCs and FDCs in most lymphomas.
authors.affiliation: a Department of Pathological Diagnostics , Yamagata University Faculty of Medicine , Yamagata , Japan.
authors.forename: Rintaro
authors.initials: R
authors.lastname: Ohe
authors.affiliation: a Department of Pathological Diagnostics , Yamagata University Faculty of Medicine , Yamagata , Japan.
authors.forename: Naing Ye
authors.initials: NY
authors.lastname: Aung
authors.affiliation: a Department of Pathological Diagnostics , Yamagata University Faculty of Medicine , Yamagata , Japan.
authors.forename: Hongxue
authors.initials: H
authors.lastname: Meng
authors.affiliation: a Department of Pathological Diagnostics , Yamagata University Faculty of Medicine , Yamagata , Japan.
authors.forename: Takanobu
authors.initials: T
authors.lastname: Kabasawa
authors.affiliation: a Department of Pathological Diagnostics , Yamagata University Faculty of Medicine , Yamagata , Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Suto
authors.affiliation: a Department of Pathological Diagnostics , Yamagata University Faculty of Medicine , Yamagata , Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Tamazawa
authors.affiliation: a Department of Pathological Diagnostics , Yamagata University Faculty of Medicine , Yamagata , Japan.
authors.forename: Suran
authors.initials: S
authors.lastname: Yang
authors.affiliation: a Department of Pathological Diagnostics , Yamagata University Faculty of Medicine , Yamagata , Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kato
authors.affiliation: a Department of Pathological Diagnostics , Yamagata University Faculty of Medicine , Yamagata , Japan.
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Yamakawa
mesh_terms: D015415:Biomarkers; D003094:Collagen / Q000378:metabolism*; D003713:Dendritic Cells / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007150:Immunohistochemistry; D008221:Lymphoid Tissue / Q000378:metabolism* / Q000473:pathology; D008224:Lymphoma, Follicular / Q000235:genetics* / Q000378:metabolism*; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D017463:Receptors, Complement 3b / Q000378:metabolism; D011503:Transglutaminases / Q000235:genetics / Q000378:metabolism
chemical_list: D015415:Biomarkers; D017463:Receptors, Complement 3b; D003094:Collagen; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins
keywords: Collagen modifying enzyme; fibroblastic reticular cell; follicular dendritic cell; malignant lymphoma