title: Association of ADIPOQ gene with type 2 diabetes and related phenotypes in African American men and women: the Jackson Heart Study.
abstract: BACKGROUND
  African Americans experience disproportionately higher prevalence of type 2 diabetes and related risk factors. Little research has been done on the association of ADIPOQ gene on type 2 diabetes, plasma adiponectin, blood glucose, HOMA-IR and body mass index (BMI) in African Americans. The objective of our research was to assess such associations with selected SNPs. The study included a sample of 3,020 men and women from the Jackson Heart Study who had ADIPOQ genotyping information. Unadjusted and adjusted regression models with covariates were used with type 2 diabetes and related phenotypes as the outcome stratified by sex.
  
  
  RESULTS
  There was no association between selected ADIPOQ SNPs with type 2 diabetes, blood glucose, or BMI in men or women. There was a significant association between variant rs16861205 and lower adiponectin in women with minor allele A in the fully adjusted model (β(SE) p = -.13(0.05), 0.003). There was also a significant association with variant rs7627128 and lower HOMA-IR among men with minor allele A in the fully adjusted model (β(SE) p = -0.74(0.20), 0.0002).
  
  
  CONCLUSIONS
  These findings represent new insights regarding the association of ADIPOQ gene and type 2 diabetes and related phenotypes in African American men and women.
authors.affiliation: National Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. sharon.davis@nih.gov.
authors.forename: Sharon K
authors.initials: SK
authors.lastname: Davis
authors.affiliation: National Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. ruihua.xu@nih.gov.
authors.forename: Ruihua
authors.initials: R
authors.lastname: Xu
authors.affiliation: National Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. samson.gebreab@nih.gov.
authors.forename: Samson Y
authors.initials: SY
authors.lastname: Gebreab
authors.affiliation: National Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. teresa.riestra@nih.gov.
authors.forename: Pia
authors.initials: P
authors.lastname: Riestra
authors.affiliation: National Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. amadou.gaye@nih.gov.
authors.forename: Amadou
authors.initials: A
authors.lastname: Gaye
authors.affiliation: National Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. rumana.khan@nih.gov.
authors.forename: Rumana J
authors.initials: RJ
authors.lastname: Khan
authors.affiliation: Department of Physiology, University of Mississippi Center, 2500 N State St, Jackson, MS, 39216, USA. jgwilson2@umc.edu.
authors.forename: James G
authors.initials: JG
authors.lastname: Wilson
authors.affiliation: Indiana University Bloomington, School of Public Health, 1025 E. 7th St, Suite 111, Bloomington, IN, 47405, USA. abidules@indiana.edu.
authors.forename: Aurelian
authors.initials: A
authors.lastname: Bidulescu
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics*; D001741:Black or African American / Q000235:genetics*; D001786:Blood Glucose; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose