title: Architectonic Mapping of the Human Brain beyond Brodmann.
abstract: Brodmann has pioneered structural brain mapping. He considered functional and pathological criteria for defining cortical areas in addition to cytoarchitecture. Starting from this idea of structural-functional relationships at the level of cortical areas, we will argue that the cortical architecture is more heterogeneous than Brodmann's map suggests. A triple-scale concept is proposed that includes repetitive modular-like structures and micro- and meso-maps. Criteria for defining a cortical area will be discussed, considering novel preparations, imaging and optical methods, 2D and 3D quantitative architectonics, as well as high-performance computing including analyses of big data. These new approaches contribute to an understanding of the brain on multiple levels and challenge the traditional, mosaic-like segregation of the cerebral cortex.
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425 Jülich, Germany; C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, 40001 Düsseldorf, Germany; JARA-BRAIN, Jülich-Aachen Research Alliance, 52425 Jülich, Germany. Electronic address: k.amunts@fz-juelich.de.
authors.forename: Katrin
authors.initials: K
authors.lastname: Amunts
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425 Jülich, Germany; JARA-BRAIN, Jülich-Aachen Research Alliance, 52425 Jülich, Germany; Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University, 52072 Aachen, Germany. Electronic address: k.zilles@fz-juelich.de.
authors.forename: Karl
authors.initials: K
authors.lastname: Zilles
mesh_terms: D001271:Atlases as Topic; D001921:Brain / Q000033:anatomy & histology* / Q000166:cytology; D001931:Brain Mapping / Q000379:methods* / Q000639:trends; D006801:Humans; D009415:Nerve Net / Q000033:anatomy & histology* / Q000166:cytology