title: Micromorphology of Skeletonized and Pedicled Internal Thoracic and Radial Arteries.
abstract: The objective of the study was to estimate the internal thoracic arteries (ITA) and radial arteries (RA) micromorphologic features by light microscopy after harvesting them using the skeletonization and pedicled methods in patients undergoing coronary artery bypass grafting. The micromorphologic characteristics of ITA and RA were studied by luminous microscopy in 61 patients undergoing coronary artery bypass grafting. A total of 122 ITA and RA segments harvested during surgery, fixed in formalin, and stained with hematoxiline and eosin were evaluated. The mean intima-media thickness of ITA was 9.2 and 134.7 µm and that of RA was 9.1 and 334.2 µm, respectively. In the distal segment of ITA the media-intima relation was 1.5 times bigger than in the proximal segment. None of ITA specimens contained atherosclerotic plaques or lipid inclusions. Atherosclerotic plaques were found in 3 (5%) RA specimens. Other degenerative changes were detected in 30%-74.2% of the specimens: splitting of internal elastic lamina, reduced tortuosity of the internal elastic lamina, and thickening and detachment of the intima; their incidence was associated with the skeletonization of the vessels. In conclusion, the incidence of ITA and RA degenerative changes varies from 30%-74.2% and its increase is associated with the skeletonization of the vessels, which is statistically significant. The media of the RA is 2.5 times thicker than that of the ITA (P < 0.01). This fact shows that RA has higher spasmogenic potential than that of ITA. The distal segment of the ITA has 1.5 times bigger media-intima relation than the proximal segment. Therefore, in case of enough graft length, it is recommended to avoid the distal segment and cut it off.
authors.affiliation: Department of diagnosis of cardiovascular diseases, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation. Electronic address: mamchse@cardio.kem.ru.
authors.forename: Sergey
authors.initials: S
authors.lastname: Mamchur
authors.affiliation: Department of diagnosis of cardiovascular diseases, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation.
authors.forename: Nikita
authors.initials: N
authors.lastname: Bokhan
authors.affiliation: Department of Cardiovascular Surgery, Research Institute of Cardiology, Tomsk, Russian Federation.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Vecherskii
authors.affiliation: Department of Cardiovascular Surgery, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation.
authors.forename: Egor
authors.initials: E
authors.lastname: Malyshenko
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008323:Mammary Arteries / Q000473:pathology* / Q000637:transplantation; D008853:Microscopy; D008875:Middle Aged; D017534:Radial Artery / Q000473:pathology* / Q000637:transplantation; D016707:Tissue Fixation; D020858:Tissue and Organ Harvesting / Q000379:methods*; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology
keywords: coronary artery bypass grafting; internal thoracic artery; micromorphology; radial artery