title: Carbohydrate polymer inspired silver nanoparticles for filaricidal and mosquitocidal activities: A comprehensive view.
abstract: The carbohydrate polymer inspired silver nanoparticles (AgNPs) are designed and synthesized through ultrasound assisted green process using unique combination of a biomolecule (tyrosine) and a natural polymer (starch). A comprehensive mechanistic study on the reactive oxygen species (ROS) mediated filaricidal (against Setaria cervi) and mosquitocidal (against second and fourth instar larvae of Culex quinquefasciatus) activities of AgNPs has been made for the first time for controlling filariasis by taking care of both filariid and its vector. The mechanism may help in formulating antifilarial drug based on carbohydrate polymer inspired AgNPs. The role of carbohydrate polymer in inspiring bioactivity of AgNPs has been looked into and its activities have been compared with the commercially available AgNPs. Cytotoxicity of AgNPs on macrophages of Wistar rat has been evaluated to ensure its selectivity towards filariid and larvae.
authors.affiliation: Polymer & Nano Research Laboratory, Department of Chemistry, Visva-Bharati University, Santiniketan 731235, India.
authors.forename: Swadhin K
authors.initials: SK
authors.lastname: Saha
authors.affiliation: Parasitology Laboratory, Department of Zoology, Visva-Bharati University, Santiniketan 731235, India.
authors.forename: Priya
authors.initials: P
authors.lastname: Roy
authors.affiliation: Parasitology Laboratory, Department of Zoology, Visva-Bharati University, Santiniketan 731235, India.
authors.forename: Prasanta
authors.initials: P
authors.lastname: Saini
authors.affiliation: Polymer & Nano Research Laboratory, Department of Chemistry, Visva-Bharati University, Santiniketan 731235, India.
authors.forename: Maloy K
authors.initials: MK
authors.lastname: Mondal
authors.affiliation: Polymer & Nano Research Laboratory, Department of Chemistry, Visva-Bharati University, Santiniketan 731235, India. Electronic address: pranesh_02@yahoo.co.in.
authors.forename: Pranesh
authors.initials: P
authors.lastname: Chowdhury
authors.affiliation: Parasitology Laboratory, Department of Zoology, Visva-Bharati University, Santiniketan 731235, India.
authors.forename: Santi P
authors.initials: SP
authors.lastname: Sinha Babu
mesh_terms: D000330:Aedes / Q000187:drug effects; D000818:Animals; D003465:Culex / Q000187:drug effects; D007306:Insecticides / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D053768:Metal Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012834:Silver / Q000737:chemistry*
chemical_list: D007306:Insecticides; D011108:Polymers; D012834:Silver
keywords: Apoptosis; Carbohydrate polymer; Filaricidal; Mosquitocidal; ROS; Silver nanoparticle