title: Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins.
abstract: We have synthesized two novel fluorescent 3-(4-diethylaminocinnamoyl) coumarins that exhibit fluorescence quenching upon exposure to a nerve agent simulant, diethylchlorophosphate (DCP), providing a basis for rapid and sensitive DCP chemosensing. Furthermore, these coumarin derivatives display two-photon fluorescence upon illumination with near-infrared laser pulses and their two-photon (TP) absorption cross-section was evaluated. The potential for TP bio-imaging of these compounds was investigated by their cellular uptake in HeLa cells by TP confocal microscopy.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110007, India. sandesh4preeti@gmail.com.
authors.forename: Preeti
authors.initials: P
authors.lastname: Yadav
authors.affiliation: Center for Advanced Materials, University of Massachusetts Lowell, Lowell, MA 01854, USA. hardeep_gill@student.uml.edu.
authors.forename: Hardeep Singh
authors.initials: HS
authors.lastname: Gill
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110007, India. kc4chemistry@gmail.com.|Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal. kc4chemistry@gmail.com.
authors.forename: Karam
authors.initials: K
authors.lastname: Chand
authors.affiliation: Center for Advanced Materials, University of Massachusetts Lowell, Lowell, MA 01854, USA. Lian_Li@uml.edu.
authors.forename: Lian
authors.initials: L
authors.lastname: Li
authors.affiliation: Center for Advanced Materials, University of Massachusetts Lowell, Lowell, MA 01854, USA. sksharma@chemistry.du.ac.in.
authors.forename: Jayant
authors.initials: J
authors.lastname: Kumar
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110007, India. jayant_kumar@uml.edu.
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Sharma
mesh_terms: D003374:Coumarins / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D000067397:Nerve Agents / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism
chemical_list: D003374:Coumarins; D005456:Fluorescent Dyes; D000067397:Nerve Agents; D009943:Organophosphorus Compounds; C548970:diethylchlorophosphate
keywords: 3-(4-diethylaminocinnamoyl) coumarins; DCP; fluorescence; nerve gas sensors; two-photon fluorescence