title: Antihyperlipidemic effect of Acanthopanax senticosus (Rupr. et Maxim) Harms leaves in high-fat-diet fed mice.
abstract: BACKGROUND
  Metabolic syndrome is a major risk factor for a variety of obesity-related diseases. Recently, the effects of functional foods have been investigated on lipid metabolism as a means to reduce lipid content in the blood, liver and adipose tissues associated with carnitine O-palmitoyltransferase (CPT) activity. Acanthopanax senticosus (Rupr. et Maxim) Harms (AS) is a medicinal herb possessing a wide spectra of functions including antioxidant, anti-inflammatory and anti-fatigue actions. Despite much research being focused on the cortical roots of AS, little information is available regarding its leaves, which are also expected to promote human health, for example by improving abnormal lipid metabolism. Here, we explored whether AS leaves affect lipid metabolism in mice fed a high-fat diet.
  
  
  RESULTS
  The administration of AS to BALB/c mice fed a high-fat diet significantly decreased plasma triglycerides (TG). CPT activity in the liver of these mice was significantly enhanced by AS treatment.
  
  
  CONCLUSIONS
  These findings indicate that AS leaves have the potential to alleviate increase in plasma TG levels due to high-fat diet intake in mice, possibly by increasing mitochondrial fatty acid β-oxidation, especially via CPT activation. Consequently, daily intake of AS leaves could promote beneficial health effects including the prevention of metabolic syndrome. © 2015 Society of Chemical Industry.
authors.affiliation: Niigata University of Pharmacy and Applied Life Sciences, Niigata, 956-8063, Japan.
authors.forename: Miyako
authors.initials: M
authors.lastname: Nishida
authors.affiliation: Niigata University of Pharmacy and Applied Life Sciences, Niigata, 956-8063, Japan.
authors.forename: Momoko
authors.initials: M
authors.lastname: Kondo
authors.affiliation: Niigata University of Pharmacy and Applied Life Sciences, Niigata, 956-8063, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Shimizu
authors.affiliation: Niigata University of Pharmacy and Applied Life Sciences, Niigata, 956-8063, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Saito
authors.affiliation: Niigata University of Pharmacy and Applied Life Sciences, Niigata, 956-8063, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Sato
authors.affiliation: Niigata University of Pharmacy and Applied Life Sciences, Niigata, 956-8063, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Hirayama
authors.affiliation: Niigata University of Pharmacy and Applied Life Sciences, Niigata, 956-8063, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Konishi
authors.affiliation: Niigata University of Pharmacy and Applied Life Sciences, Niigata, 956-8063, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishida
mesh_terms: D000818:Animals; D002334:Carnitine O-Palmitoyltransferase / Q000378:metabolism; D059305:Diet, High-Fat; D028001:Eleutherococcus; D006949:Hyperlipidemias / Q000097:blood / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008807:Mice, Inbred BALB C; D008928:Mitochondria / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D014280:Triglycerides / Q000097:blood*
chemical_list: D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D002334:Carnitine O-Palmitoyltransferase
keywords: Acanthopanax senticosus (Rupr. et Maxim) Harms; carnitine O-palmitoyltransferase activity; hyperlipidemia; metabolic syndrome