title: Purpura fulminans associated with acute West Nile virus encephalitis.
abstract: Purpura fulminans is a progressive thrombotic disorder that presents with widespread purpura due to deficiency or dysfunction of protein C or protein S. Lesions present as well-demarcated erythematous macules that progress to irregular areas of hemorrhagic necrosis.West Nile virus is a member of the Flaviviridae family transmitted to humans through the bite of various mosquito species. It manifests as West Nile fever in 25% of those infected and less commonly as neuroinvasive disease. An African American man in his fortiespresented with altered mental status and was noted to have evidence of disseminated intravascular coagulation according to his lab data. He then developed dusky skin discoloration and systemic flaccid bullae with desquamation. Biopsy was consistent with purpura fulminans and the patient eventually developed symmetric peripheral gangrene, requiring amputations of all four extremities. Infectious work up revealed positive testing for IgM and IgG antibodies in serum and cerebrospinal fluid leading to the diagnosis of acute West Nile Virus encephalitis. We present this case to describe the rarely reported association of purpura fulminans with West Nile Virus infection.
authors.affiliation: Texas A&M Health Science Center College of Medicine, Temple, TX, United States.
authors.forename: Sheevam
authors.initials: S
authors.lastname: Shah
authors.affiliation: Department of Dermatology, Scott & White Memorial Hospital, Temple, TX, United States. Electronic address: lfite@sw.org.
authors.forename: Laura Paul
authors.initials: LP
authors.lastname: Fite
authors.affiliation: Department of Dermatology, Scott & White Memorial Hospital, Temple, TX, United States.
authors.forename: Natalie
authors.initials: N
authors.lastname: Lane
authors.affiliation: Department of Dermatology, Scott & White Memorial Hospital, Temple, TX, United States.
authors.forename: Palak
authors.initials: P
authors.lastname: Parekh
mesh_terms: D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005734:Gangrene / Q000209:etiology / Q000601:surgery; D006801:Humans; D008297:Male; D055665:Purpura Fulminans / Q000209:etiology*; D014901:West Nile Fever / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology*; D014902:West Nile virus
keywords: Encephalitis; Fulminans; Nile; Purpura; Virus; West