title: Protein arrays for biomarker discovery in lupus.
abstract: Lupus is one of the most common autoimmune diseases, yet many mechanisms of its pathogenesis are not fully known. Over the last few years, advances in protein array technology have accelerated rapidly, resulting in many promising insights toward the discovery of novel lupus biomarkers that may become useful in disease diagnosis and management. Still, only two types of analytical protein arrays thus far, being antibody and antigen arrays, have found notable usage toward lupus biomarker discovery. In this review, we summarize current protein array technologies being used for biomarker discoveries in lupus and associated biomarker findings, as well as protein arrays that are likely to be used for lupus biomarker discovery in the near future.
authors.affiliation: Department of Biomedical Engineering, University of Houston, Houston, TX, USA.
authors.forename: Taylor E
authors.initials: TE
authors.lastname: Hinchliffe
authors.affiliation: Department of Biomedical Engineering, University of Houston, Houston, TX, USA.
authors.forename: Zuan-Tao
authors.initials: ZT
authors.lastname: Lin
authors.affiliation: Department of Biomedical Engineering, University of Houston, Houston, TX, USA.
authors.forename: Tianfu
authors.initials: T
authors.lastname: Wu
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000097:blood*; D015551:Autoimmunity; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D016207:Cytokines / Q000097:blood; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D040081:Protein Array Analysis / Q000295:instrumentation / Q000379:methods*; D020543:Proteome / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D015415:Biomarkers; D001798:Blood Proteins; D016207:Cytokines; D020543:Proteome
keywords: Aptamer; Diagnostics; Lupus; Plasmonics; Protein array