title: Regulatory roles of phosphorylation in model and pathogenic fungi.
abstract: Over the past 20 years, considerable advances have been made toward our understanding of how post-translational modifications affect a wide variety of biological processes, including morphology and virulence, in medically important fungi. Phosphorylation stands out as a key molecular switch and regulatory modification that plays a critical role in controlling these processes. In this article, we first provide a comprehensive and up-to-date overview of the regulatory roles that both Ser/Thr and non-Ser/Thr kinases and phosphatases play in model and pathogenic fungi. Next, we discuss the impact of current global approaches that are being used to define the complete set of phosphorylation targets (phosphoproteome) in medically important fungi. Finally, we provide new insights and perspectives into the potential use of key regulatory kinases and phosphatases as targets for the development of novel and more effective antifungal strategies.
authors.affiliation: Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
authors.forename: Mohammad T
authors.initials: MT
authors.lastname: Albataineh
authors.affiliation: Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 kadosh@uthscsa.edu.
authors.forename: David
authors.initials: D
authors.lastname: Kadosh
mesh_terms: D005656:Fungal Proteins / Q000378:metabolism / Q000502:physiology; D005658:Fungi / Q000201:enzymology / Q000378:metabolism / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D009181:Mycoses; D010750:Phosphoproteins; D010744:Phosphoric Monoester Hydrolases; D010766:Phosphorylation / Q000502:physiology*; D010770:Phosphotransferases; D020543:Proteome
chemical_list: D005656:Fungal Proteins; D010750:Phosphoproteins; D020543:Proteome; D010770:Phosphotransferases; D010744:Phosphoric Monoester Hydrolases
keywords: human fungal pathogens; kinases; phosphatases; phosphoproteome; phosphorylation