title: Patient global assessment in psoriatic arthritis - what does it mean? An analysis of 223 patients from the Psoriatic arthritis impact of disease (PsAID) study.
abstract: OBJECTIVE
  Patient global assessment is a key outcome measure in psoriatic arthritis. To explore the meaning of patient global assessment in psoriatic arthritis by examining associations to domains of health assessed by the Psoriatic arthritis impact of disease score.
  
  
  METHODS
  Post-hoc analysis of a multicentre cross-sectional study of patients with psoriatic arthritis. Data collection included patient global assessment, specific joint and skin global patient assessments, Psoriatic arthritis impact of disease questions covering physical (including joints and skin), psychological and social impact, and other comparator outcomes. Univariate analyses (Pearson correlation) and multivariate linear regression were performed to explain patient global assessment and the specific joint and skin global patient assessments.
  
  
  RESULTS
  Among 223 patients (mean age: 51.0 [standard deviation, ±13.3] years; mean disease duration: 9.9 [±10.1] years; mean swollen joint count: 4.1 [±5.1]; 84.3% with current psoriasis [mainly of less than 5% body surface area]), 50.2% were females. Mean patient global assessment was 4.8 (±2.7), mean joint and skin patient assessments were respectively 5.6 (±2.5) and 4.1 (±3.0). Intraclass correlation between patient global assessment and joint or skin patient assessment was respectively 0.71 (95% confidence interval, 0.64-0.77) and 0.52 (95% confidence interval, 0.42-0.60). In multivariate analyses, patient global assessment was explained (R(2) of model: 0.754) by coping (β = 0.287); pain (β = 0.240); work and/or leisure activities (β = 0.141); and anxiety (β = 0.109).
  
  
  CONCLUSIONS
  Patient global assessment in psoriatic arthritis was explained mainly by physical, but also psychological aspects of the disease.
authors.affiliation: Sorbonne universités, UPMC université Paris 06, institut Pierre-Louis d'épidémiologie et de santé publique, 75013 Paris, France; AP-HP, Pitié-Salpêtrière hospital, department of rheumatology, 47-83, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Tälli
authors.affiliation: Paris Descartes university, department of rheumatology, Cochin hospital and epidemiology, 75014 Paris, France; Biostatistics unit, Sorbonne Paris Cité research center, Inserm U1153, 75004 Paris, France.
authors.forename: Adrien
authors.initials: A
authors.lastname: Etcheto
authors.affiliation: Sorbonne universités, UPMC université Paris 06, institut Pierre-Louis d'épidémiologie et de santé publique, 75013 Paris, France; AP-HP, Pitié-Salpêtrière hospital, department of rheumatology, 47-83, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Fautrel
authors.affiliation: Research center of rheumatic diseases, Sf. Maria hospital, university of medicine and pharmacy Carol Davila, 011172 Bucharest, Romania.
authors.forename: Andra
authors.initials: A
authors.lastname: Balanescu
authors.affiliation: Rheumazentrum Ruhrgebiet, 44649 Herne, Germany; Ruhr-Universität Bochum, 44801 Bochum, Germany.
authors.forename: Jurgen
authors.initials: J
authors.lastname: Braun
authors.affiliation: Arthritis unit, department of rheumatology, hospital Clínic and IDIBAPS, 08036 Barcelona, Spain.
authors.forename: Juan D
authors.initials: JD
authors.lastname: Cañete
authors.affiliation: Department of rheumatology, university hospitals Leuven, 1348 Leuven, Belgium.
authors.forename: Kurt
authors.initials: K
authors.lastname: de Vlam
authors.affiliation: People with Arthritis/Rheumatism in Europe (PARE), 8000 Zurich, Switzerland.
authors.forename: Maarten
authors.initials: M
authors.lastname: de Wit
authors.affiliation: Faculty of health and social studies, Oestfold university college, NO-1757 Halden, regional research support Oslo, university hospital Postbox 4956 Nydalen, NO-0424 Oslo, Norway.
authors.forename: Turid
authors.initials: T
authors.lastname: Heiberg
authors.affiliation: Institute of rheumatic and musculoskeletal medicine, university of Leeds, LS2 9JT Leeds, United Kindom.
authors.forename: Philip
authors.initials: P
authors.lastname: Helliwell
authors.affiliation: University faculty of medicine, division of rheumatology, 06560 Ankara, Turkey.
authors.forename: Umut
authors.initials: U
authors.lastname: Kalyoncu
authors.affiliation: Rheumazentrum Ruhrgebiet, 44649 Herne, Germany; Ruhr-Universität Bochum, 44801 Bochum, Germany.
authors.forename: Uta
authors.initials: U
authors.lastname: Kiltz
authors.affiliation: Associazione per la Difesa degli Psoriasici (ADIPSO) - Pan European Psoriasis Patients' Organization Forum (PE.Pso.POF), 00193 Rome, Italy.
authors.forename: Mara
authors.initials: M
authors.lastname: Maccarone
authors.affiliation: 3rd rheumatology department, National institute of rheumatology and physiotherapy, 1051 Budapest, Hungary.
authors.forename: Dora
authors.initials: D
authors.lastname: Niedermayer
authors.affiliation: East-Tallinn central hospital, rheumatology department, 10001 Tallinn, Estonia.
authors.forename: Kati
authors.initials: K
authors.lastname: Otsa
authors.affiliation: Dipartimento di medicina interna e specialità mediche, reumatologia, Sapienza università di Roma, 00185 Rome, Italy.
authors.forename: Rossana
authors.initials: R
authors.lastname: Scrivo
authors.affiliation: Division of rheumatology, department of medicine 3, medical university of Vienna, 2nd department of medicine, Hietzing hospital, 1130 Vienna, Austria.
authors.forename: Josef S
authors.initials: JS
authors.lastname: Smolen
authors.affiliation: Division of rheumatology, department of medicine 3, medical university of Vienna, 2nd department of medicine, Hietzing hospital, 1130 Vienna, Austria; University of applied sciences FH Campus Wien, department of health, division of health assisting engineering, 1140 Vienna, Austria.
authors.forename: Tanja
authors.initials: T
authors.lastname: Stamm
authors.affiliation: Dublin academic medical centre, Saint-Vincent's university hospital, Elm Park, Dublin 4, Ireland.
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Veale
authors.affiliation: Department of rheumatology, Diakonhjemmet hospital, 0370 Oslo, Norway.
authors.forename: Tore K
authors.initials: TK
authors.lastname: Kvien
authors.affiliation: Sorbonne universités, UPMC université Paris 06, institut Pierre-Louis d'épidémiologie et de santé publique, 75013 Paris, France; AP-HP, Pitié-Salpêtrière hospital, department of rheumatology, 47-83, boulevard de l'Hôpital, 75013 Paris, France. Electronic address: laure.gossec@psl.aphp.fr.
authors.forename: Laure
authors.initials: L
authors.lastname: Gossec
mesh_terms: D000328:Adult; D015535:Arthritis, Psoriatic / Q000150:complications / Q000523:psychology; D017281:Cost of Illness; D005060:Europe; D005260:Female; D014943:Global Health; D006801:Humans; D008297:Male; D008875:Middle Aged; D063868:Patient Outcome Assessment
keywords: Outcome measure; Pain; Patient global assessment; PsAID; Psoriatic arthritis