title: Contralateral breast dose from partial breast brachytherapy.
abstract: The purpose of this study was to determine the dose to the contralateral breast during accelerated partial breast irradiation (APBI) and to compare it to external beam-published values. Thermoluminescent dosimeter (TLD) packets were used to measure the dose to the most medial aspect of the contralateral breast during APBI simulation, daily quality assurance (QA), and treatment. All patients in this study were treated with a single-entry, multicatheter device for 10 fractions to a total dose of 34 Gy. A mark was placed on the patient's skin on the medial aspect of the opposite breast. Three TLD packets were taped to this mark during the pretreatment simulation. Simulations consisted of an AP and Lateral scout and a limited axial scan encompassing the lumpectomy cavity (miniscan), if rotation was a concern. After the simulation the TLD packets were removed and the patients were moved to the high-dose-rate (HDR) vault where three new TLD packets were taped onto the patients at the skin mark. Treatment was administered with a Nucletron HDR afterloader using Iridium-192 as the treatment source. Post-treatment, TLDs were read (along with the simulation and QA TLD and a set of standards exposed to a known dose of 6 MV photons). Measurements indicate an average total dose to the contralateral breast of 70 cGy for outer quadrant implants and 181 cGy for inner quadrant implants. Compared to external beam breast tangents, these results point to less dose being delivered to the contralateral breast when using APBI.
authors.affiliation: The University of Texas M.D. Anderson Cancer Center. rcrobins@mdanderson.org.
authors.forename: R Cole
authors.initials: RC
authors.lastname: Robinson
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Nelson
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Bloom
authors.forename: Kelly D
authors.initials: KD
authors.lastname: Kisling
authors.forename: Bryan E
authors.initials: BE
authors.lastname: Mason
authors.forename: Gary D
authors.initials: GD
authors.lastname: Fisher
authors.forename: Steven M
authors.initials: SM
authors.lastname: Kirsner
mesh_terms: D001918:Brachytherapy / Q000379:methods* / Q000592:standards / Q000706:statistics & numerical data; D001940:Breast / Q000528:radiation effects; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D015412:Mastectomy, Segmental; D011785:Quality Assurance, Health Care; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods / Q000706:statistics & numerical data; D013819:Thermoluminescent Dosimetry; D014057:Tomography, X-Ray Computed
chemical_list: D007496:Iridium Radioisotopes