title: Developmental Pathways Direct Pancreatic Cancer Initiation from Its Cellular Origin.
abstract: Pancreatic ductal adenocarcinoma (PDA) is characterized by an extremely poor prognosis, since it is usually diagnosed at advanced stages. In order to employ tools for early detection, a better understanding of the early stages of PDA development from its main precursors, pancreatic intraepithelial neoplasia (PanIN), and intraductal papillary mucinous neoplasm (IPMN) is needed. Recent studies on murine PDA models have identified a different exocrine origin for PanINs and IPMNs. In both processes, developmental pathways direct the initiation of PDA precursors from their cellular ancestors. In this review, the current understanding of early PDA development is summarized.
authors.affiliation: II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar München, Technische Universität München, 81675 Munich, Germany ; Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Reichert
authors.affiliation: II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar München, Technische Universität München, 81675 Munich, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Blume
authors.affiliation: Department of Internal Medicine I, Ulm University, 89081 Ulm, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kleger
authors.affiliation: Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar München, Technische Universität München, 81675 Munich, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hartmann
authors.affiliation: II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar München, Technische Universität München, 81675 Munich, Germany.
authors.forename: Guido
authors.initials: G
authors.lastname: von Figura