title: Near infrared fluorescent imaging after intravenous injection of indocyanine green during neck dissection in patients with head and neck cancer: A feasibility study.
abstract: Indocyanine green (ICG) has not been studied during therapeutic lymph node dissections after intravenous injection. The purpose of this study was to explore the distribution of ICG in lymphatic nodes during neck dissection.
  
  
  
  Eleven patients requiring neck dissection with or without resection of the primary lesion were included. ICG was intravenously injected at induction time of anesthesia. Imaging was performed before and after surgical resection. Fluorescence was measured in arbitrary units (AUs) in the pathology department. Mixed linear model and generalized estimating equations (GEEs) were used.
  
  
  
  Mean fluorescence of invaded nodes was 22.6 AUs (SD = 24.9) and 3.9 AUs (SD = 8.1) in negative nodes (p = .016). After adjustment for the size of the node, the risk of invasion when fluorescence was observed was 12.2 (95% confidence interval [CI] = 5.3-28.2; p < .0001).
  
  
  
  This study demonstrates the feasibility of ICG to bring a contrast during surgery between healthy and invaded nodes after i.v. injection. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1833-E1837, 2016.
authors.affiliation: Department of Head and Neck Surgery, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: Antoine
authors.initials: A
authors.lastname: Digonnet
authors.affiliation: Department of Nuclear Medicine, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: Sophie
authors.initials: S
authors.lastname: van Kerckhove
authors.affiliation: Department of Biostatistics, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: Michel
authors.initials: M
authors.lastname: Moreau
authors.affiliation: Department of Head and Neck Surgery, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: Esther
authors.initials: E
authors.lastname: Willemse
authors.affiliation: Department of Head and Neck Surgery, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: Marie
authors.initials: M
authors.lastname: Quiriny
authors.affiliation: Department of Nuclear Medicine, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: Bissan
authors.initials: B
authors.lastname: Ahmed
authors.affiliation: Department of Pathology, Jules Bordet Institute, Université Libre de Bruxelles, Belgium.
authors.forename: Nicolas
authors.initials: N
authors.lastname: de Saint Aubain
authors.affiliation: Department of Head and Neck Surgery, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: Guy
authors.initials: G
authors.lastname: Andry
authors.affiliation: Department of Nuclear Medicine, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Bourgeois
mesh_terms: D000328:Adult; D000368:Aged; D005240:Feasibility Studies; D005456:Fluorescent Dyes; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging*; D006801:Humans; D007208:Indocyanine Green; D007275:Injections, Intravenous; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008875:Middle Aged; D037981:Neck Dissection; D061848:Optical Imaging
chemical_list: D005456:Fluorescent Dyes; D007208:Indocyanine Green
keywords: fluorescence abstract; indocyanine green; lymph node; neck dissection; oncology