title: Antifungal Susceptibility and Phylogeny of Opportunistic Members of the Genus Fusarium Causing Human Keratomycosis in South India.
abstract: Fusarium species are reported frequently as the most common causative agents of fungal keratitis in tropical countries such as India. Sixty-five fusaria isolated from patients were subjected to multilocus DNA sequencing to characterize the spectrum of the species associated with keratitis infections in India. Susceptibilities of these fusaria to ten antifungals were determined in vitro by the broth microdilution method. An impressive phylogenetic diversity of fusaria was reflected in susceptibilities differing at species level. Typing results revealed that the isolates were distributed among species in the species complexes (SCs) of F. solani (FSSC; n = 54), F. oxysporum (FOSC; n = 1), F. fujikuroi (FFSC; n = 3), and F. dimerum (FDSC; n = 7). Amphotericin B, voriconazole, and clotrimazole proved to be the most effective drugs, followed by econazole.
authors.affiliation: Department of Microbiology, Dr. G.R. Damodaran College of Science, Coimbatore, India.
authors.forename: Anamangadan Shafeeq
authors.initials: AS
authors.lastname: Hassan
authors.affiliation: CBS-KNAW Fungal Biodiversity Centre, Utrecht, the Netherlands Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, the Netherlands Directorate General of Health Services, Ministry of Health, Ibri Hospital, Ibri, Oman.
authors.forename: Abdullah M S
authors.initials: AM
authors.lastname: Al-Hatmi
authors.affiliation: Department of Microbiology, PSG College of Arts & Science, Coimbatore, India.
authors.forename: Coimbatore Subramanian
authors.initials: CS
authors.lastname: Shobana
authors.affiliation: CBS-KNAW Fungal Biodiversity Centre, Utrecht, the Netherlands.
authors.forename: Anne D
authors.initials: AD
authors.lastname: van Diepeningen
authors.affiliation: Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Kredics
authors.affiliation: Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary Botany and Microbiology Department, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Csaba
authors.initials: C
authors.lastname: Vágvölgyi
authors.affiliation: Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
authors.forename: Mónika
authors.initials: M
authors.lastname: Homa
authors.affiliation: Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: Jacques F
authors.initials: JF
authors.lastname: Meis
authors.affiliation: CBS-KNAW Fungal Biodiversity Centre, Utrecht, the Netherlands Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, the Netherlands Basic Pathology Department, Federal University of Paraná State, Curitiba, Paraná, Brazil.
authors.forename: G Sybren
authors.initials: GS
authors.lastname: de Hoog
authors.affiliation: Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, India.
authors.forename: Venkatapathy
authors.initials: V
authors.lastname: Narendran
authors.affiliation: Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, India Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Kingdom of Saudi Arabia Greenlink Analytical and Research Laboratory India Private Ltd., Coimbatore, India. manikandanpalanisamy@gmail.com.
authors.forename: Palanisamy
authors.initials: P
authors.lastname: Manikandan
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D025141:Drug Resistance, Fungal; D015821:Eye Infections, Fungal / Q000382:microbiology*; D060585:Fusariosis / Q000382:microbiology*; D005670:Fusarium / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007194:India; D007634:Keratitis / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D058885:Multilocus Sequence Typing; D010802:Phylogeny
chemical_list: D000935:Antifungal Agents
keywords: Bisifusarium; Keratitis; Neocosmospora; treatment options