title: Rabbit Model for Superantigen-Mediated Lethal Pulmonary Disease.
abstract: Staphylococcus aureus is a highly significant cause of serious human infections in the USA. Many of these illnesses are mediated by interactions between the host immune system and staphylococcal superantigens (SAgs). Several of these severe staphylococcal infections are initiated in the lungs, making this an important site to study. Here, we describe the rabbit model for investigating the role of staphylococcal SAgs in pulmonary-associated lethal infection and intoxication.
authors.affiliation: Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA. krististrandberg@gmail.com.
authors.forename: Kristi L
authors.initials: KL
authors.lastname: Strandberg
authors.affiliation: Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
authors.forename: Jessica H
authors.initials: JH
authors.lastname: Rotschafer
authors.affiliation: Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Schlievert
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage / Q000276:immunology; D004195:Disease Models, Animal; D007114:Immunization; D008171:Lung Diseases / Q000276:immunology* / Q000382:microbiology* / Q000401:mortality / Q000517:prevention & control; D011817:Rabbits; D013211:Staphylococcus aureus / Q000276:immunology*; D018089:Superantigens / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D018089:Superantigens
keywords: Pulmonary infection; Pulmonary intoxication; Rabbit model; Staphylococcus aureus; Superantigen; Toxic shock syndrome