title: Cobalt(iii) catalyzed C-8 selective C-H and C-O coupling of quinoline N-oxide with internal alkynes via C-H activation and oxygen atom transfer.
abstract: An efficient, scalable, atom-economical, regio-selective air stable Cp*Co(iii) catalyzed C-H and C-O coupling via a C-H activation/oxygen atom transfer reaction of quinoline N-oxide and an internal alkyne is reported. Such a catalytic transformation is witnessed for the first time with a cobalt catalyst and using N-oxide as a traceless directing group, in contrast to the existing literature. The developed synthetic methodology is straightforward and possesses various functional group tolerances, including heterocycles.
authors.affiliation: Fine Chemical Laboratory, Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, UP, India. basker@iitk.ac.in.
authors.forename: Nagaraju
authors.initials: N
authors.lastname: Barsu
authors.affiliation: Fine Chemical Laboratory, Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, UP, India. basker@iitk.ac.in.
authors.forename: Malay
authors.initials: M
authors.lastname: Sen
authors.affiliation: Center for Molecular Modelling, Indian Institute of Chemical Technology, Hyderabad - 500 067, India.
authors.forename: J Richard
authors.initials: JR
authors.lastname: Premkumar
authors.affiliation: Fine Chemical Laboratory, Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, UP, India. basker@iitk.ac.in.
authors.forename: Basker
authors.initials: B
authors.lastname: Sundararaju
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*
chemical_list: D000480:Alkynes; D011804:Quinolines; D003035:Cobalt