title: Improvement in the signs and symptoms of dry eye disease with dobesilate eye drops.
abstract: BACKGROUND
  Dry eye is a multifactor disease of the tear film and ocular surface that substantially affects quality of life.
  
  
  METHODS
  Dobesilate administered as eye drops was well tolerated and effective in treating both the objective signs and subjective symptoms of dry eye disease in this 2-week study.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first clinical report of using dobesilate in eye drops. Dobesilate may provide a novel approach to treating drying diseases of the eye.
authors.affiliation: Facultad de Medicina, Universidad Alfonso X, Madrid, Spain ; Departamento de Oftalmología, Hospital de Día Pío XII, Madrid, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Cuevas
authors.affiliation: Departamento de Oftalmología, Hospital de Día Pío XII, Madrid, Spain.
authors.forename: Luis Antonio
authors.initials: LA
authors.lastname: Outeiriño
authors.affiliation: Departamento de Oftalmología, Hospital de Día Pío XII, Madrid, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Azanza
authors.affiliation: Servicio de Histología. Departamento de Investigación, IRYCIS; Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Angulo
authors.affiliation: Departamento de Estructura y Función de Proteínas, Centro de Investigaciones Biológicas. CSIC, Madrid, Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Giménez-Gallego
keywords: Dobesilate eye drops; Dry eye disease; Fibroblast growth factor; Vascular endothelial growth factor