title: Effect of NaFeEDTA-Fortified Soy Sauce on Anemia Prevalence in China: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
abstract: OBJECTIVE
  To assess the effect of sodium iron ethylenediaminetetraacetate (NaFeEDTA)-fortified soy sauce on anemia prevalence in the Chinese population.
  
  
  METHODS
  A systematic review was performed to identify potential studies by searching the electronic databases of PubMed, Cochrane Library, WHO Library, HighWire, CNKI, and other sources. The selection criteria included randomized controlled trials that compared the efficacy of NaFeEDTA-fortified soy sauce with that of non-fortified soy sauce. Anemia rates and hemoglobin levels were the outcomes of interest. Inclusion decisions, quality assessment, and data extraction were performed by two reviewers independently. A total of 16 studies met the inclusion criteria for anemia rate analysis, of which 12 studies met the inclusion criteria for hemoglobin analysis. All included studies assessed the effect of NaFeEDTA-fortified soy sauce on anemia rates and hemoglobin concentrations.
  
  
  RESULTS
  After the intervention, the hemoglobin concentration increased and anemia rates decreased significantly as compared with the non-fortified soy sauce groups. For anemia rates, data from 16 studies could be pooled, and the pooled estimate odds ratio was 0.25 (95% CI 0.19-0.35). For hemoglobin concentrations, data from 12 studies could be pooled, and the pooled weighted mean difference was 8.81 g/L (95% CI 5.96-11.67).
  
  
  CONCLUSIONS
  NaFeEDTA-fortified soy sauce has a positive effect on anemia control and prevention in the at-risk population.
authors.affiliation: Key Laboratory of trace element nutrition of Ministry of health, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Beijing 100050, China.
authors.forename: Jun Sheng
authors.initials: JS
authors.lastname: Huo
authors.affiliation: Key Laboratory of trace element nutrition of Ministry of health, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Beijing 100050, China.
authors.forename: Ji Yong
authors.initials: JY
authors.lastname: Yin
authors.affiliation: Key Laboratory of trace element nutrition of Ministry of health, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Beijing 100050, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: Key Laboratory of trace element nutrition of Ministry of health, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Beijing 100050, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.affiliation: Global Alliance of Improved Nutrition, Singapore 247672, Singapore.
authors.forename: Zhen Xin
authors.initials: ZX
authors.lastname: Lu
authors.affiliation: Global Alliance of Improved Nutrition, Singapore 247672, Singapore.
authors.forename: Moench-Pfanner
authors.initials: MP
authors.lastname: Regina
authors.affiliation: Key Laboratory of trace element nutrition of Ministry of health, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Beijing 100050, China.
authors.forename: Jun Shi
authors.initials: JS
authors.lastname: Chen
authors.affiliation: Key Laboratory of trace element nutrition of Ministry of health, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Beijing 100050, China.
authors.forename: Chun Ming
authors.initials: CM
authors.lastname: Chen
mesh_terms: D000367:Age Factors; D018798:Anemia, Iron-Deficiency / Q000453:epidemiology / Q000517:prevention & control*; D002681:China / Q000453:epidemiology; D004492:Edetic Acid; D005290:Ferric Compounds; D005527:Food, Fortified; D006400:Hematocrit; D006801:Humans; D015995:Prevalence; D016032:Randomized Controlled Trials as Topic; D045730:Soy Foods
chemical_list: D005290:Ferric Compounds; D004492:Edetic Acid; C019179:Fe(III)-EDTA
keywords: Anemia; Food fortification; Hemoglobin; Iron deficiency; Meta-analyses; NaFeEDTA; Sodium iron ethylenediaminetetraacetate