title: Baicalin Reverses Depressive-Like Behaviours and Regulates Apoptotic Signalling Induced by Olfactory Bulbectomy.
abstract: Apoptosis is thought to be involved in neurological disorders including major depression. In this study, we examined whether the polyphenolic compound baicalin could decrease apoptosis in the olfactory bulbectomy (OBX) depression rat model. OBX rats exhibited decreased performance in depression-like behavioural tests and showed evidence of increased oxidative stress, decreased synaptophysin expression, and hippocampal apoptosis. Treatment with baicalin (20 and 40 mg/kg) significantly reversed all of these changes. Baicalin modulated the levels or activity of malondialdehyde, superoxide dismutase, and glutathione peroxidase and prevented apoptotic protease-activating factor-1 expression, effectively suppressing caspase-mediated apoptosis signalling cascades. Our results demonstrate that baicalin has potent antidepressant activity, likely because of its ability to suppress apoptosis.
authors.affiliation: Discipline of Chinese and Western Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210046, China.
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Yu
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Zhu-Jun
authors.initials: ZJ
authors.lastname: Yin
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Shui-Jin
authors.initials: SJ
authors.lastname: Yang
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Shi-Ping
authors.initials: SP
authors.lastname: Ma
authors.affiliation: Discipline of Chinese and Western Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210046, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Qu
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D053477:Apoptotic Protease-Activating Factor 1 / Q000378:metabolism; D001522:Behavior, Animal / Q000187:drug effects; D020169:Caspases / Q000378:metabolism; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D005979:Glutathione Peroxidase / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009830:Olfactory Bulb; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D017208:Rats, Wistar; D031363:Scutellaria / Q000737:chemistry*; D015398:Signal Transduction / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D000928:Antidepressive Agents; D053477:Apoptotic Protease-Activating Factor 1; D005419:Flavonoids; D010936:Plant Extracts; D016708:Synaptophysin; C038044:baicalin; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D020169:Caspases
keywords: Apaf-1; apoptosis; baicalin; caspase-3; caspase-9; olfactory bulbectomy