title: Duration of Systemic Inflammation in the First Postnatal Month Among Infants Born Before the 28th Week of Gestation.
abstract: Extremely low gestational age newborns (ELGANs, <28 completed weeks of gestation) that exhibit fetal and neonatal systemic inflammatory responses are at increased risk for developmental adversity, especially if the inflammatory process is sustained. We evaluated pro-inflammatory cytokine patterns in whole blood of 1220 ELGANs on one or more of postnatal days 1, 7, 14, 21, and 28. Protein concentrations were divided into quartiles within gestational week categories. We calculated odds ratios (OR) with 99% confidence intervals (CI) for having a concentration in the top quartile for each protein given that the infant had a protein concentration in the top quartile 1 week or more earlier compared to infants who did not. ELGANs who have elevated systemic levels of IL-6R, TNF-α, or RANTES on their first postnatal day are approximately twice as likely to have elevated levels of these cytokines at the end of each of the first postnatal month. In some, this twofold risk increase persisted for the entire first postnatal month. In extremely preterm newborns, inflammatory processes can be sustained over weeks.
authors.affiliation: Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA. olaf.dammann@tufts.edu.|Perinatal Neuropidemiology Unit, Hannover Medical School, Hannover, Germany. olaf.dammann@tufts.edu.
authors.forename: Olaf
authors.identifier: http://orcid.org/0000-0002-0046-4863
authors.initials: O
authors.lastname: Dammann
authors.affiliation: Neuroepidemiology Unit, Department of Neurology, Boston Children's Hospital, Harvard University, Boston, MA, USA.
authors.forename: Elizabeth N
authors.initials: EN
authors.lastname: Allred
authors.affiliation: Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Raina N
authors.initials: RN
authors.lastname: Fichorova
authors.affiliation: Division of Neurology, Department of Pediatrics, Boston Medical Center and Boston University, Boston, MA, USA.
authors.forename: Karl
authors.initials: K
authors.lastname: Kuban
authors.affiliation: Department of Pediatrics, Wake Forest University, Winston-Salem, NC, USA.
authors.forename: T Michael
authors.initials: TM
authors.lastname: O'Shea
authors.affiliation: Neuroepidemiology Unit, Department of Neurology, Boston Children's Hospital, Harvard University, Boston, MA, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Leviton
mesh_terms: D018946:Chemokine CCL5 / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism; D005865:Gestational Age; D006801:Humans; D062071:Infant, Extremely Premature / Q000378:metabolism*; D007231:Infant, Newborn; D019947:Receptors, Interleukin-6 / Q000378:metabolism*; D018746:Systemic Inflammatory Response Syndrome / Q000473:pathology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: C483024:CCL5 protein, human; D018946:Chemokine CCL5; D016207:Cytokines; C508603:IL6R protein, human; D019947:Receptors, Interleukin-6; D014409:Tumor Necrosis Factor-alpha
keywords: cytokines; inflammation; newborn; preterm birth