title: A new metal-organic polymeric system capable of stimuli-responsive controlled release of the drug ibuprofen.
abstract: A series of new zinc compounds has been prepared easily under mild synthetic conditions with the drug ibuprofen incorporated as a ligand to form different coordination polymers. The host materials have a high drug content and exhibit high stability, low cytotoxicity, good biodegradability and high biocompatibility. The ion exchange mechanism involved in the ibuprofen release process and the pH-controlled drug release have been studied.
authors.affiliation: Departamento de Química Inorgánica, Facultade de Química, Instituto de Investigación Biomédica (IBI)-Universidade de Vigo, 36310 Vigo, Galicia, Spain. ablago@uvigo.es.
authors.forename: Ana Belén
authors.initials: AB
authors.lastname: Lago
authors.forename: Arantxa
authors.initials: A
authors.lastname: Pino-Cuevas
authors.forename: Rosa
authors.initials: R
authors.lastname: Carballo
authors.forename: Ezequiel M
authors.initials: EM
authors.lastname: Vázquez-López
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000737:chemistry*; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013499:Surface Properties; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D009942:Organometallic Compounds; D011108:Polymers; D015032:Zinc; D007052:Ibuprofen