title: [Cancer stem cells: Radiotherapeutic features and therapeutic targets].
abstract: Recent evidences suggest that many types of cancers contain a cell population presenting stem cell properties. While the great majority of tumor cells are destined to differentiate, and eventually stop dividing, only a minority population of cells, termed cancer stem cells (CSCs), possesses extensive self-renewal capability and can recapitulate tumor pathophysiology in an immune-compromised animal model. Tumor initiating cells have been identified and isolated in many tumor types including brain, colon and prostate. They are virtually resistant to radiation and may contribute to treatment resistance and recurrence. Therefore, therapies specifically targeting CSCs will likely be needed for complete tumor eradication. The present study reviews published reports identifying the mechanisms of radioresistance of CSCs and potential targets based on the pathways of self-renewal. Further elucidation of pathways that regulate CSCs may provide insights into the development of novel innovative therapies.
authors.affiliation: Institut de cancérologie de la Loire-Lucien-Neuwirth, département de radiothérapie, 108, bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France; Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France.
authors.forename: Benoîte
authors.initials: B
authors.lastname: Méry
authors.affiliation: Institut de cancérologie de la Loire-Lucien-Neuwirth, département de radiothérapie, 108, bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Chloé
authors.initials: C
authors.lastname: Rancoule
authors.affiliation: Institut de cancérologie de la Loire-Lucien-Neuwirth, département de radiothérapie, 108, bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France; Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Guy
authors.affiliation: Institut de cancérologie de la Loire-Lucien-Neuwirth, département de radiothérapie, 108, bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Espenel
authors.affiliation: Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Wozny
authors.affiliation: Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Simonet
authors.affiliation: Institut de cancérologie de la Loire-Lucien-Neuwirth, département de radiothérapie, 108, bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Vallard
authors.affiliation: Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France.
authors.forename: Gersende
authors.initials: G
authors.lastname: Alphonse
authors.affiliation: Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Ardail
authors.affiliation: Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Rodriguez-Lafrasse
authors.affiliation: Institut de cancérologie de la Loire-Lucien-Neuwirth, département de radiothérapie, 108, bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France; Faculté de médecine Lyon-Sud, laboratoire de radiobiologie cellulaire et moléculaire de Lyon-Sud, EMR 3738, 165, chemin du Grand-Revoyet, BP 12, 69921 Oullins cedex, France. Electronic address: nicolas.magne@icloire.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Magné
mesh_terms: D002455:Cell Division; D060833:Cellular Microenvironment; D004260:DNA Repair; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D009364:Neoplasm Recurrence, Local; D009369:Neoplasms / Q000473:pathology / Q000628:therapy; D014411:Neoplastic Stem Cells / Q000502:physiology / Q000528:radiation effects*; D011836:Radiation Tolerance / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D053823:Hedgehog Proteins; D016328:NF-kappa B; D017382:Reactive Oxygen Species
keywords: Cancer stem cells (CSCs); Cellules souches tumorales; Cibles; Pathways; Radioresistance; Radiorésistance; Radiotherapy; Radiothérapie; Review; Revue de la littérature; Targets; Voies de signalisation