title: The Good, the Bad, or the Pretty: IL-17 Builds Lymphoid Tissues in the Brain.
abstract: Lymph node development depends on well-orchestrated interactions between lymphoid tissue inducer cells and stromal cells. In this issue of Immunity, Pikor and colleagues (2015) find that signals from IL-17-producing T helper cells can alter the stromal microenvironment of the inflamed brain to generate a neo-lymphoid organ that drives further inflammation.
authors.affiliation: Institute of Experimental Immunology, Inflammation Research, University of Zurich, 8057 Zurich, Switzerland. Electronic address: becher@immunology.uzh.ch.
authors.forename: Burkhard
authors.initials: B
authors.lastname: Becher
mesh_terms: D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D005260:Female; D006801:Humans; D008233:Lymphotoxin-alpha / Q000276:immunology*; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000276:immunology*; D017154:Stromal Cells / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D008233:Lymphotoxin-alpha