title: Genomic Discoveries and Personalized Medicine in Neurological Diseases.
abstract: In the past decades, we have witnessed dramatic changes in clinical diagnoses and treatments due to the revolutions of genomics and personalized medicine. Undoubtedly we also met many challenges when we use those advanced technologies in drug discovery and development. In this review, we describe when genomic information is applied in personal healthcare in general. We illustrate some case examples of genomic discoveries and promising personalized medicine applications in the area of neurological disease particular. Available data suggest that individual genomics can be applied to better treat patients in the near future.
authors.affiliation: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. lizhang07@gmail.com.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: U.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA. Huixiao.Hong@fda.hhs.gov.
authors.forename: Huixiao
authors.initials: H
authors.lastname: Hong
keywords: genomics; neurological disease; personalized medicine