title: The Impact of Visual Field Clusters on Performance-based Measures and Vision-Related Quality of Life in Patients With Glaucoma.
abstract: OBJECTIVE
  To investigate how visual field (VF) clusters affect performance-based measures of the ability to perform activities of daily living and subjective measures of vision-related quality of life (QoL) in patients with glaucoma.
  
  
  METHODS
  Prospective, cross-sectional study.
  
  
  METHODS
  setting: Institutional - Wills Eye Hospital.
  
  
  METHODS
  322 eyes of 161 patients with moderate-stage glaucoma.
  
  
  METHODS
  VF tests were conducted using the Humphrey 24-2 Swedish Interactive Thresholding Algorithm standard perimeter. The VFs of each patient were divided into 5 clusters: nasal, temporal, central, paracentral, and peripheral. The score for each cluster was the averaged total deviation scores of all tested points within the cluster. Each cluster score was correlated with performance-based measures of visual function and subjective assessment of vision-related QoL.
  
  
  METHODS
  The Compressed Assessment of Ability Related to Vision, the National Eye Institute Visual Functioning Questionnaire 25 (NEI VFQ-25), and the Modified Glaucoma Symptom Scale.
  
  
  RESULTS
  The central VF cluster in the better eye was positively correlated with all Compressed Assessment of Ability Related to Vision (performance-based measure) subscales. The strongest correlation for the better eye was between the central VF cluster and total Compressed Assessment of Ability Related to Vision score (0.39, P < .001). The inferior VF hemisphere in both eyes was positively correlated with most Compressed Assessment of Ability Related to Vision subscales. Central VF clusters in the better eye were positively correlated with a majority of the NEI VFQ-25 subscales. There were no significant correlations between VF clusters and Modified Glaucoma Symptom Scale subscales.
  
  
  CONCLUSIONS
  Scores of central VF defects in the better eye and inferior hemisphere defects in both eyes were positively correlated with performance-based measures of the ability to perform activities of daily living. Glaucoma patients with central defects in the better eye were more likely to have reduced scores on assessments of vision-related QoL.
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital, Philadelphia, Pennsylvania.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital, Philadelphia, Pennsylvania.
authors.forename: Clarissa
authors.initials: C
authors.lastname: Lin
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital, Philadelphia, Pennsylvania.
authors.forename: Michael
authors.initials: M
authors.lastname: Waisbourd
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital, Philadelphia, Pennsylvania.
authors.forename: Feyzahan
authors.initials: F
authors.lastname: Ekici
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital, Philadelphia, Pennsylvania.
authors.forename: Elif
authors.initials: E
authors.lastname: Erdem
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital, Philadelphia, Pennsylvania.
authors.forename: Sheryl S
authors.initials: SS
authors.lastname: Wizov
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital, Philadelphia, Pennsylvania.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Hark
authors.affiliation: Glaucoma Research Center, Wills Eye Hospital, Philadelphia, Pennsylvania. Electronic address: gspaeth@willseye.org.
authors.forename: George L
authors.initials: GL
authors.lastname: Spaeth
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D005901:Glaucoma / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D014065:Tonometry, Ocular; D014786:Vision Disorders / Q000503:physiopathology*; D014792:Visual Acuity / Q000502:physiology*; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*