title: Polycystic Kidney Disease: Lessons Learned from Caenorhabditis elegans Mating Behavior.
abstract: Male worm mating requires lov-1 and pkd-2 (homologs of the human polycystic kidney disease genes, PKD1 and PKD2), which are expressed in male-specific neurons. Transcriptomic analysis of these neurons now catalogs molecules involved in signaling and ectosome biogenesis, with implications for human PKD.
authors.affiliation: Department of Internal Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, KS 66103, USA. Electronic address: cward6@kumc.edu.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Ward
authors.affiliation: Department of Internal Medicine, Division of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, KS 66103, USA.
authors.forename: Madhulika
authors.initials: M
authors.lastname: Sharma
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D007690:Polycystic Kidney Diseases / Q000235:genetics; D012726:Sexual Behavior, Animal; D050396:TRPP Cation Channels / Q000235:genetics* / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; C515011:LOV-1 protein, C elegans; C527777:PKD-2 protein, C elegans; D050396:TRPP Cation Channels