title: A critical role of interleukin-1 in preterm labor.
abstract: Preterm birth (PTB) is a leading cause of neonatal mortality and morbidity worldwide, and represents a heavy economic and social burden. Despite its broad etiology, PTB has been firmly linked to inflammatory processes. Pro-inflammatory cytokines are produced in gestational tissues in response to stressors and can prematurely induce uterine activation, which precedes the onset of preterm labor. Of all cytokines implicated, interleukin (IL)-1 has been largely studied, revealing a central role in preterm labor. However, currently approved IL-1-targeting therapies have failed to show expected efficacy in pre-clinical studies of preterm labor. Herein, we (a) summarize animal and human studies in which IL-1 or IL-1-targeting therapeutics are implicated with preterm labor, (b) focus on novel IL-1-targeting therapies and diagnostic tests, and (c) develop the case for commercialization and translation means to hasten their development.
authors.affiliation: Departments of Pediatrics, Ophthalmology and Pharmacology, CHU Sainte-Justine Research Center, Montréal H3T 1C5, Canada; Department of Pharmacology, Université de Montréal, Montréal H3C 3J7, Canada.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Nadeau-Vallée
authors.affiliation: Department of Pharmacology, Université de Montréal, Montréal H3C 3J7, Canada.
authors.forename: Dima
authors.initials: D
authors.lastname: Obari
authors.affiliation: Departments of Pediatrics, Ophthalmology and Pharmacology, CHU Sainte-Justine Research Center, Montréal H3T 1C5, Canada.
authors.forename: Christiane
authors.initials: C
authors.lastname: Quiniou
authors.affiliation: Department of Chemistry, Université de Montréal, Montréal, Québec H3C 3J7, Canada.
authors.forename: William D
authors.initials: WD
authors.lastname: Lubell
authors.affiliation: Departments of Obstetrics and Gynecology, Pediatrics and Physiology, University of Alberta, Edmonton AB TG6 2S2, Canada.
authors.forename: David M
authors.initials: DM
authors.lastname: Olson
authors.affiliation: Departments of Obstetrics and Gynecology, CHU Sainte-Justine Research Centre, Montréal H3T 1C5, Canada. Electronic address: sylvie.girard@recherche-ste-justine.qc.ca.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Girard
authors.affiliation: Departments of Pediatrics, Ophthalmology and Pharmacology, CHU Sainte-Justine Research Center, Montréal H3T 1C5, Canada. Electronic address: sylvain.chemtob@umontreal.ca.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Chemtob
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation / Q000276:immunology; D007375:Interleukin-1 / Q000276:immunology*; D058990:Molecular Targeted Therapy; D007752:Obstetric Labor, Premature / Q000276:immunology* / Q000517:prevention & control; D011247:Pregnancy; D047928:Premature Birth / Q000276:immunology / Q000517:prevention & control
chemical_list: D007375:Interleukin-1
keywords: Infection; Inflammation; Interleukin-1; Preterm birth; Preterm labor