title: Maternal and neonatal epidemiological features in clinical subtypes of preterm birth.
abstract: This study was designed to characterize and compare the maternal and newborn epidemiological characteristics through analysis of environmental factors, sociodemographic characteristics and clinical characteristics between the different clinical subtypes of preterm birth (PTB): Idiopathic (PTB-I), premature rupture of the membranes (PTB-PPROM) and medically indicated (PTB-M). The two subtypes PTB-I and PTB-PPROM grouped are called spontaneous preterm births (PTB-S).
  
  
  
  A retrospective, observational study was conducted in 1.291 preterm nonmalformed singleton live-born children to nulliparous and multiparous mother's in Tucumán-Argentina between 2005 and 2010. Over 50 maternal variables and 10 newborn variables were compared between the different clinical subtypes. The comparisons were done to identify heterogeneity between subtypes of preterm birth: (PTB-S) versus (PTB-M), and within spontaneous subtype: (PTB-I) versus (PTB-PPROM). In the same way, two conditional logistic multivariate regressions were used to compare the odds ratio (OR) between PTB-S and PTB-M, as well as PTB-I and PTB-PPROM. We matched for maternal age when comparing maternal variables and gestational age when comparing infant variables.
  
  
  
  The PTB-I subtype was characterized by younger mothers of lower socio-economic status, PTB-PPROM was characterized by environmental factors resulting from inflammatory processes, and PTB-M was characterized by increased maternal or fetal risk pregnancies.
  
  
  
  The main risk factor for PTB-I and PTB-M was having had a prior preterm delivery; however, previous spontaneous abortion was not a risk factor, suggesting a reproductive selection mechanism.
authors.affiliation: a Dirección De Investigación, CEMIC (Centro De Educación Médica E Investigaciones Clínicas) , Galván 4102 , Buenos Aires , Argentina .|b ECLAMC (Estudio Colaborativo Latinoamericano De Malformaciones Congénitas) at CEMIC , Buenos Aires , Argentina .
authors.forename: Lucas G
authors.initials: LG
authors.lastname: Gimenez
authors.affiliation: a Dirección De Investigación, CEMIC (Centro De Educación Médica E Investigaciones Clínicas) , Galván 4102 , Buenos Aires , Argentina .
authors.forename: Hugo B
authors.initials: HB
authors.lastname: Krupitzki
authors.affiliation: c Department of Pediatrics , University of Iowa , IA , USA .
authors.forename: Allison M
authors.initials: AM
authors.lastname: Momany
authors.affiliation: a Dirección De Investigación, CEMIC (Centro De Educación Médica E Investigaciones Clínicas) , Galván 4102 , Buenos Aires , Argentina .|b ECLAMC (Estudio Colaborativo Latinoamericano De Malformaciones Congénitas) at CEMIC , Buenos Aires , Argentina .
authors.forename: Juan A
authors.initials: JA
authors.lastname: Gili
authors.affiliation: a Dirección De Investigación, CEMIC (Centro De Educación Médica E Investigaciones Clínicas) , Galván 4102 , Buenos Aires , Argentina .|b ECLAMC (Estudio Colaborativo Latinoamericano De Malformaciones Congénitas) at CEMIC , Buenos Aires , Argentina .|d Fundação Oswaldo Cruz, INAGEMP (Instituto Nacional De Genética Médica Populacional) at Laboratório De Epidemiologia De Malformações Congênitas, Instituto Oswaldo Cruz , Rio De Janeiro , Brazil .
authors.forename: Fernando A
authors.initials: FA
authors.lastname: Poletta
authors.affiliation: e CIC (Comisión De Investigaciones Científicas) at La Plata , Buenos Aires , Argentina , and.
authors.forename: Hebe
authors.initials: H
authors.lastname: Campaña
authors.affiliation: b ECLAMC (Estudio Colaborativo Latinoamericano De Malformaciones Congénitas) at CEMIC , Buenos Aires , Argentina .
authors.forename: Viviana R
authors.initials: VR
authors.lastname: Cosentino
authors.affiliation: f Maternidad Nuestra Señora De La Merced , Tucumán , Argentina.
authors.forename: César
authors.initials: C
authors.lastname: Saleme
authors.affiliation: a Dirección De Investigación, CEMIC (Centro De Educación Médica E Investigaciones Clínicas) , Galván 4102 , Buenos Aires , Argentina .|b ECLAMC (Estudio Colaborativo Latinoamericano De Malformaciones Congénitas) at CEMIC , Buenos Aires , Argentina .
authors.forename: Mariela
authors.initials: M
authors.lastname: Pawluk
authors.affiliation: c Department of Pediatrics , University of Iowa , IA , USA .
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Murray
authors.affiliation: b ECLAMC (Estudio Colaborativo Latinoamericano De Malformaciones Congénitas) at CEMIC , Buenos Aires , Argentina .|d Fundação Oswaldo Cruz, INAGEMP (Instituto Nacional De Genética Médica Populacional) at Laboratório De Epidemiologia De Malformações Congênitas, Instituto Oswaldo Cruz , Rio De Janeiro , Brazil .
authors.forename: Eduardo E
authors.initials: EE
authors.lastname: Castilla
authors.affiliation: a Dirección De Investigación, CEMIC (Centro De Educación Médica E Investigaciones Clínicas) , Galván 4102 , Buenos Aires , Argentina .
authors.forename: Enrique C
authors.initials: EC
authors.lastname: Gadow
authors.affiliation: a Dirección De Investigación, CEMIC (Centro De Educación Médica E Investigaciones Clínicas) , Galván 4102 , Buenos Aires , Argentina .|b ECLAMC (Estudio Colaborativo Latinoamericano De Malformaciones Congénitas) at CEMIC , Buenos Aires , Argentina .|d Fundação Oswaldo Cruz, INAGEMP (Instituto Nacional De Genética Médica Populacional) at Laboratório De Epidemiologia De Malformações Congênitas, Instituto Oswaldo Cruz , Rio De Janeiro , Brazil .
authors.forename: Jorge S
authors.initials: JS
authors.lastname: Lopez-Camelo
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D001118:Argentina / Q000453:epidemiology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D047928:Premature Birth / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D012959:Socioeconomic Factors; D055815:Young Adult
keywords: Clinical subtypes; epidemiological features; pregnancy; preterm birth