title: Synthesis, antibacterial and cytotoxic activities of new biflorin-based hydrazones and oximes.
abstract: Biflorin 1 is a biologically active quinone, isolated from Capraria biflora. Five new biflorin-based nitrogen derivatives were synthesized, of which two were mixtures of (E)- and (Z)- isomers: (Z)-2a, (Z)-2b, (Z)-3a, (Z)- and (E)-3b, (Z)- and (E)-3c. The antibacterial activity was investigated using the microdilution method for determining the minimum inhibitory concentration (MIC) against six bacterial strains. Tests have shown that these derivatives have potential against all bacterial strains. The cytotoxic activity was also evaluated against three strains of cancer cells, but none of the derivatives showed activity.
authors.affiliation: Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Campus do Pici, 60451-970 Fortaleza, CE, Brazil.
authors.forename: Luciana G
authors.initials: LG
authors.lastname: da S Souza
authors.affiliation: Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Campus do Pici, 60451-970 Fortaleza, CE, Brazil.
authors.forename: Macia C S
authors.initials: MCS
authors.lastname: Almeida
authors.affiliation: Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Campus do Pici, 60451-970 Fortaleza, CE, Brazil. Electronic address: tlemos@ufc.br.
authors.forename: Telma L G
authors.initials: TLG
authors.lastname: Lemos
authors.affiliation: Embrapa Agroindustria Tropical, R Dra Sara Mesquita, 2270, 60511-110 Fortaleza, CE, Brazil.
authors.forename: Paulo R V
authors.initials: PRV
authors.lastname: Ribeiro
authors.affiliation: Embrapa Agroindustria Tropical, R Dra Sara Mesquita, 2270, 60511-110 Fortaleza, CE, Brazil.
authors.forename: Edy S
authors.initials: ES
authors.lastname: de Brito
authors.affiliation: Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal.
authors.forename: Vera L M
authors.initials: VLM
authors.lastname: Silva
authors.affiliation: Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: artur.silva@ua.pt.
authors.forename: Artur M S
authors.initials: AMS
authors.lastname: Silva
authors.affiliation: Laboratório de Ciências Químicas, Universidade Estadual do Norte Fluminense Darcy Ribeiro, 28013-602 Campos dos Goytacazes, RJ, Brazil.
authors.forename: Raimundo
authors.initials: R
authors.lastname: Braz-Filho
authors.affiliation: Laboratório de Pesquisa de Produtos Naturais, Universidade Regional do Cariri, 63105-000 Crato, CE, Brazil.
authors.forename: José G M
authors.initials: JGM
authors.lastname: Costa
authors.affiliation: Laboratório de Pesquisa de Produtos Naturais, Universidade Regional do Cariri, 63105-000 Crato, CE, Brazil.
authors.forename: Fábio F G
authors.initials: FFG
authors.lastname: Rodrigues
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, 60430-270 Fortaleza, CE, Brazil.
authors.forename: Francisco S
authors.initials: FS
authors.lastname: Barreto
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, 60430-270 Fortaleza, CE, Brazil.
authors.forename: Manoel O
authors.initials: MO
authors.lastname: de Moraes
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D045744:Cell Line, Tumor; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D028083:Scrophulariaceae / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D006835:Hydrazones; D009285:Naphthoquinones; D010091:Oximes; C522781:biflorin
keywords: Antibacterial; Antitumoral; Biflorin; Hydrazones; Oximes