title: Efficacy and Safety of Landiolol Compared to Amiodarone for the Management of Postoperative Atrial Fibrillation in Intensive Care Patients.
abstract: OBJECTIVE
  The authors assessed the efficacy and safety of landiolol, an ultra-short-acting beta-blocker, with those of amiodarone in the restoration of sinus rhythm for postoperative atrial fibrillation (POAF) in intensive care unit (ICU) patients.
  
  
  METHODS
  A retrospective data analysis.
  
  
  METHODS
  Data were collected from patients admitted to the ICU in a single university hospital between 2012 and 2015.
  
  
  METHODS
  Records of a total of 276 patients who developed POAF after ICU admission were collected from hospital records.
  
  
  METHODS
  None.
  
  
  RESULTS
  Treatment success was defined as restoration of sinus rhythm without concomitant therapy within 24 hours of treatment and lasting for more than an hour. The landiolol dosage was in the range of 0.7 µg/kg/min-to-2.5 µg/kg/min. The authors compared a total of 55 patients with POAF who received either landiolol (n = 32) or intravenous amiodarone (n = 23) in the ICU. The major findings were that the median time required for conversion to sinus rhythm was shorter in landiolol patients compared with amiodarone patients (75 v 150 min respectively, p = 0.0355). However, treatment success rates did not differ significantly after 24 hours (odds ratio 1.25, 95% confidence interval 0.17-9.09, p = 0.60). Adverse events with bradycardia leading to drug discontinuation were seen only in the patients receiving amiodarone (n = 3, p = 0.032).
  
  
  CONCLUSIONS
  Landiolol achieved swift and safe restoration of sinus rhythm in ICU patients with POAF and could be considered as a favorable drug choice over amiodarone in such patients.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medicine, Osaka University, Yamadaoka Suita, Osaka, Japan. Electronic address: karlshibata@pain.med.osaka-u.ac.jp.
authors.forename: Sho C
authors.initials: SC
authors.lastname: Shibata
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medicine, Osaka University, Yamadaoka Suita, Osaka, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Uchiyama
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medicine, Osaka University, Yamadaoka Suita, Osaka, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ohta
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medicine, Osaka University, Yamadaoka Suita, Osaka, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Fujino
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy*; D003422:Critical Care; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000009:adverse effects / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy*; D012189:Retrospective Studies; D014508:Urea / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000889:Anti-Arrhythmia Agents; D009025:Morpholines; C077049:landiolol; D014508:Urea; D000638:Amiodarone
keywords: amiodarone; beta-blocker; intensive care; landiolol; postoperative atrial fibrillation