title: Statin Use, Incident Dementia and Alzheimer Disease in Elderly African Americans.
abstract: OBJECTIVE
  To investigate the association between statin use, incident dementia, and Alzheimer disease (AD) in a prospective elderly African American cohort.
  
  
  METHODS
  Two stage design with a screening interview followed by a comprehensive in-home assessment conducted over an eight-year period. Diagnoses of incident AD and dementia were made by consensus. Statin use was collected at each evaluation. Measurements of low-density lipoprotein cholesterol (LDL), C-reactive protein (CRP) and APOE genotype were obtained from baseline blood samples. Logistic regression models were used to test the association of statin use on incident dementia and AD and its possible association with lipid and CRP levels.
  
  
  METHODS
  Indianapolis, Indiana.
  
  
  METHODS
  From an original cohort of 2629 participants, a subsample of 974 African Americans aged >70 years with normal cognition, at least one follow up evaluation, complete statin information, and biomarker availability were included.
  
  
  METHODS
  Incident dementia and incident AD.
  
  
  RESULTS
  After controlling for age at diagnosis, sex, education level, presence of the APOE ε4 allele and history of stroke for the incident dementia model, baseline use of statins was associated with a significantly decreased risk of incident dementia (OR=.44, P=.029) and incident AD (OR=.40, P=.029). The significant effect of statin use on reduced AD risk and trend for dementia risk was found only for those participants who reported consistent use over the observational period (incident AD: P=.034; incident dementia: P=.061). Additional models found no significant interaction between baseline statin use, baseline LDL, or CRP level and incident dementia/AD.
  
  
  CONCLUSIONS
  Consistent use of statin medications during eight years of follow-up resulted in significantly reduced risk for incident AD and a trend toward reduced risk for incident dementia.
authors.affiliation: 1. Center for Aging Research, Indiana University School of Medicine ; 4. Department of Psychiatry, Indiana University School of Medicine.
authors.forename: Hugh C
authors.initials: HC
authors.lastname: Hendrie
authors.affiliation: 2. Department of Neurology, Indiana University School of Medicine.
authors.forename: Ann
authors.initials: A
authors.lastname: Hake
authors.affiliation: 3. Department of Biostatistics, Indiana University School of Medicine.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Lane
authors.affiliation: 1. Center for Aging Research, Indiana University School of Medicine.
authors.forename: Christianna
authors.initials: C
authors.lastname: Purnell
authors.affiliation: 4. Department of Psychiatry, Indiana University School of Medicine.
authors.forename: Frederick
authors.initials: F
authors.lastname: Unverzagt
authors.affiliation: 4. Department of Psychiatry, Indiana University School of Medicine.
authors.forename: Valerie
authors.initials: V
authors.lastname: Smith-Gamble
authors.affiliation: 5. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine.
authors.forename: Jill
authors.initials: J
authors.lastname: Murrell
authors.affiliation: 6. College of Medicine, University of Ibadan, Nigeria.
authors.forename: Adesola
authors.initials: A
authors.lastname: Ogunniyi
authors.affiliation: 6. College of Medicine, University of Ibadan, Nigeria.
authors.forename: Olusegun
authors.initials: O
authors.lastname: Baiyewu
authors.affiliation: 1. Center for Aging Research, Indiana University School of Medicine.
authors.forename: Chris
authors.initials: C
authors.lastname: Callahan
authors.affiliation: 7. Center for Neuroimaging, Indiana University School of Medicine.
authors.forename: Andrew
authors.initials: A
authors.lastname: Saykin
authors.affiliation: 3. Department of Biostatistics, Indiana University School of Medicine.
authors.forename: Stanley
authors.initials: S
authors.lastname: Taylor
authors.affiliation: 4. Department of Psychiatry, Indiana University School of Medicine.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Hall
authors.affiliation: 3. Department of Biostatistics, Indiana University School of Medicine.
authors.forename: Su
authors.initials: S
authors.lastname: Gao
mesh_terms: D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000188:drug therapy / Q000208:ethnology*; D008078:Cholesterol, LDL / Q000097:blood; D003704:Dementia / Q000097:blood / Q000188:drug therapy / Q000208:ethnology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D015994:Incidence; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: African Americans; Alzheimer Disease; Cohort Studies; Dementia; Hydroxymethylglutaryl-CoA Reductase Inhibitors