title: An unexpected Bromolactamization of Olefinic Amides Using a Three-Component Co-catalyst System.
abstract: Reaction between (N,N-dimethylamino)pyridine and isocyanate unexpectedly produced a three-component mixture. By using this mixture as an unprecedented three-component catalyst system, a facile and selective bromolactamization of olefinic amides has been developed. The protocol confers enhanced selectivity of N- over O-cyclization, leading to the formation of a structurally diverse range of lactams including both small and medium ring sizes.
authors.affiliation: Department of Chemistry, National University of Singapore , 3 Science Drive 3, Singapore 117543.
authors.forename: Yi An
authors.initials: YA
authors.lastname: Cheng
authors.affiliation: Department of Chemistry, National University of Singapore , 3 Science Drive 3, Singapore 117543.
authors.forename: Wesley Zongrong
authors.initials: WZ
authors.lastname: Yu
authors.affiliation: Department of Chemistry, The Chinese University of Hong Kong , Shatin, NT, Hong Kong, China.|Department of Chemistry, National University of Singapore , 3 Science Drive 3, Singapore 117543.
authors.forename: Ying-Yeung
authors.initials: YY
authors.lastname: Yeung