title: Comparison of three different concurrent chemoradiation regimens for treatment of laryngeal cancer.
abstract: During last decades, laryngeal organ preservation strategies have emerged. The data about the oncological outcomes mainly come from multi-institutional prospective studies. In this study, we aimed to determine the oncological outcomes of different organ preservation regimens applied in routine practice. Patients who had definitive concurrent chemoradiation (CRT) for treatment of laryngeal cancer between January 2001 and June 2013 were retrospectively reviewed. There were 139 subjects who met the inclusion criteria. Three groups were defined: group A (n = 59) consisted of subjects who had concurrent cisplatin and radiotherapy (RT), group B (n = 47) consisted of subjects who had cisplatin/docetaxel-based concurrent CRT, and group C (n = 33) had induction chemotherapy before concurrent cisplatin and RT. The Kaplan-Meier estimated 5-year overall survival, disease-specific survival, disease-free survival, and local recurrence-free survival (LRFS) rates for the whole study group were 66.5, 69.2, 69.6, and 88.9 %, respectively. None of these survival rates were statistically different when the treatment arms were compared. The 3- and 5-year LRFS rates were significantly lower in subjects with a T4a tumor (p = 0.030). According to our results, the oncological outcomes of three different platinum-based concurrent chemotherapy schemes were similar and high local control rates could be achieved with the use of these protocols. Neoadjuvant chemotherapy before concurrent CRT was not superior to conventional concurrent treatment.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Gazi University School of Medicine, Beşevler, 06500, Ankara, Turkey. utkuaydil@yahoo.com.
authors.forename: Utku
authors.initials: U
authors.lastname: Aydil
authors.affiliation: Department of Radiation Oncology, Gazi University School of Medicine, Ankara, Turkey.
authors.forename: Müge
authors.initials: M
authors.lastname: Akmansu
authors.affiliation: Department of Medical Oncology, Gazi University School of Medicine, Ankara, Turkey.
authors.forename: Özge
authors.initials: Ö
authors.lastname: Gumusay
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Gazi University School of Medicine, Beşevler, 06500, Ankara, Turkey.
authors.forename: Faruk Kadri
authors.initials: FK
authors.lastname: Bakkal
authors.affiliation: Department of Radiation Oncology, Gazi University School of Medicine, Ankara, Turkey.
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Yazıcı
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Gazi University School of Medicine, Beşevler, 06500, Ankara, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Kızıl
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Gazi University School of Medicine, Beşevler, 06500, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Köybaşıoğlu
authors.affiliation: Department of Medical Oncology, Gazi University School of Medicine, Ankara, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Yıldız
authors.affiliation: Department of Medical Oncology, Gazi University School of Medicine, Ankara, Turkey.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Büyükberber
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Gazi University School of Medicine, Beşevler, 06500, Ankara, Turkey.
authors.forename: Erdoğan
authors.initials: E
authors.lastname: İnal
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D059248:Chemoradiotherapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D011446:Prospective Studies; D012074:Remission Induction; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D014421:Turkey / Q000453:epidemiology
chemical_list: D000970:Antineoplastic Agents
keywords: Concurrent chemoradiotherapy; Laryngectomy; Larynx cancer; Neoadjuvant therapy; Survival