title: Genetic predisposition to acute lymphoblastic leukemia: Overview on behalf of the I-BFM ALL Host Genetic Variation Working Group.
abstract: Environmental causes of childhood acute lymphoblastic leukemia (ALL) remain largely undiscovered. In contrast, multiple germline ALL risk variants have been identified in the recent years. Apart from the low-risk common ALL risk alleles identified through genome wide association studies, rare germline mutations that cause cancer prone syndromes have been found to be associated with an increased risk of developing ALL. Here, we review the germline genetic changes known to be associated with ALL.
authors.affiliation: Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany. Electronic address: kratz.christian@mh-hannover.de.
authors.forename: Christian Peter
authors.initials: CP
authors.lastname: Kratz
authors.affiliation: Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Stanulla
authors.affiliation: Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpital Robert Debré, Département de Génétique, Paris, France; INSERM UMR 1131, Institut Universitaire d'Hématologie, Université Paris Diderot, Paris-Sorbonne-Cité, Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Cavé
mesh_terms: D000367:Age Factors; D000483:Alleles; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D018095:Germ-Line Mutation; D006801:Humans; D015994:Incidence; D019683:Penetrance; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D012306:Risk; D013577:Syndrome
keywords: Acute lymphoblastic leukemia; Cancer predisposition; Germline mutation; Risk variants