title: Proposal of Gleason-like grading system of canine prostate carcinoma in veterinary pathology practice.
abstract: Gleason grading - the most useful predictor of prognosis for prostate cancer in men - was updated at a 2005 consensus conference by the International Society of Urological Pathology. Since Gleason-like growth patterns have been recognised in dogs, this study aimed to apply the modified Gleason grading to 45 canine prostate carcinomas. A single primary growth pattern was observed in 28 cases, a secondary pattern in 11 cases and a tertiary pattern in 6 cases. Cribriform, solid and small acinar/ductal were the most common primary, secondary and tertiary morphological patterns, respectively. The highest Gleason score (GS10) was obtained in 46.7% of cases. Nine of 14 metastasizing cases were classified as GS10. Gleason pattern 5 was present in 33 of cases. This study suggests that the modified Gleason grading, based on specific histological growth patterns existing in canine prostate carcinomas, may be accepted as a grading system for histopathology in the practice settings in order to complete the clinical assessment for the best management of the patient.
authors.affiliation: School of Veterinary Science, The University of Queensland, Gatton Campus, 4343 Gatton, Queensland, Australia. Electronic address: c.palmieri@uq.edu.au.
authors.forename: Chiara
authors.initials: C
authors.lastname: Palmieri
authors.affiliation: Department of Veterinary Science and Public Health, Universita' degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy. Electronic address: valeria.grieco@unimi.it.
authors.forename: Valeria
authors.initials: V
authors.lastname: Grieco
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D008297:Male; D060787:Neoplasm Grading; D011471:Prostatic Neoplasms / Q000473:pathology / Q000662:veterinary*
keywords: Carcinoma; Dog; Gleason grading; Prostate