title: Cardiovascular medicine heart failure (CVM-HF) index as prognostic model for candidates to MitraClip therapy.
abstract: Transcatheter MitraClip repair is a new tool for the management of severe mitral regurgitation in patients at very high risk for conventional surgery. Aim of our study was reporting one-year clinical outcomes in candidates to MitraClip procedures, divided into three groups according to the cardiovascular medicine heart failure (CVM-HF) index. The study population consists of 46 consecutive patients, divided, in accordance with CVM-HF index, as follows: one patient in the low-risk category (group A); 27 patients in the medium-risk (group B) and 18 patients in high-risk category (group C). The primary study endpoint was a combined of all-cause mortality and re-hospitalization rate. Secondary endpoints were all-cause mortality and cardiac mortality. Patients of group B and group C were compared. Regarding the primary endpoint, patients in group C had significantly poorer outcomes than patients in group B, with a 12-month survival freedom from events of 44.4  and 74.1 %, respectively (log-rank test, p = 0.039); survival freedom from cardiac mortality was 100 and 83.3 % in group B and C, respectively (log-rank test, p = 0.027). One-year survival free from re-hospitalization was 74.1 % in group B and 39.9 % in group C (log-rank test; p = 0.036). Survival free from all-cause of mortality was 92.6 and 77.8 %, respectively (log-rank test; p = 0.129). In our initial experience the CVM-HF index showed to be valuable for understanding if the patient with advanced heart failure and functional mitral regurgitation can really benefit by MitraClip therapy.
authors.affiliation: Department of Cardiovascular Disease, Tor Vergata University of Rome, Viale Oxford, 81, 00133, Rome, Italy. gpussia@hotmail.com.
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Ussia
authors.affiliation: Department of Cardiovascular Disease, Tor Vergata University of Rome, Viale Oxford, 81, 00133, Rome, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Cammalleri
authors.affiliation: Department of Cardiovascular Disease, Tor Vergata University of Rome, Viale Oxford, 81, 00133, Rome, Italy.
authors.forename: Ersilia
authors.initials: E
authors.lastname: Mazzotta
authors.affiliation: Department of Cardiovascular Disease, Tor Vergata University of Rome, Viale Oxford, 81, 00133, Rome, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Pascuzzo
authors.affiliation: Department of Cardiovascular Disease, Tor Vergata University of Rome, Viale Oxford, 81, 00133, Rome, Italy.
authors.forename: Saverio
authors.initials: S
authors.lastname: Muscoli
authors.affiliation: Department of Cardiovascular Disease, Tor Vergata University of Rome, Viale Oxford, 81, 00133, Rome, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Marchei
authors.affiliation: Department of Cardiovascular Disease, Tor Vergata University of Rome, Viale Oxford, 81, 00133, Rome, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Macrini
authors.affiliation: Department of Cardiovascular Disease, Tor Vergata University of Rome, Viale Oxford, 81, 00133, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Anceschi
authors.affiliation: Department of Cardiovascular Disease, Tor Vergata University of Rome, Viale Oxford, 81, 00133, Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Romeo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006328:Cardiac Catheterization / Q000295:instrumentation*; D002423:Cause of Death; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000175:diagnosis* / Q000401:mortality; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000601:surgery*; D010359:Patient Readmission / Q000706:statistics & numerical data*; D011183:Postoperative Complications / Q000209:etiology; D016896:Treatment Outcome
keywords: Heart failure; MitraClip; Mitral regurgitation; Prognosis