title: Sclerosing Lesions of the Orbit: A Review.
abstract: Orbital sclerosing inflammation is a distinct group of pathologies characterized by indolent growth with minimal or no signs of inflammation. However, contrary to earlier classifications, it should not be considered a chronic stage of acute inflammation. Although rare, orbital IgG4-related disease has been associated with systemic sclerosing pseudotumor-like lesions. Possible mechanisms include autoimmune and IgG4 related defective clonal proliferation. Currently, there is no specific treatment protocol for IgG4-related disease although the response to low dose steroid provides a good response as compared to non-IgG4 sclerosing pseudotumor. Specific sclerosing inflammations (e.g. Wegener's disease, sarcoidosis, Sjogren's syndrome) and neoplasms (lymphoma, metastatic breast carcinoma) should be ruled out before considering idiopathic sclerosing inflammation as a diagnosis.
authors.affiliation: Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Gautam
authors.initials: G
authors.lastname: Lokdarshi
authors.affiliation: Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Neelam
authors.initials: N
authors.lastname: Pushker
authors.affiliation: Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Mandeep S
authors.initials: MS
authors.lastname: Bajaj
mesh_terms: D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006942:Hypergammaglobulinemia / Q000188:drug therapy / Q000209:etiology*; D007074:Immunoglobulin G / Q000276:immunology*; D009915:Orbit / Q000473:pathology*; D016727:Orbital Pseudotumor / Q000188:drug therapy / Q000209:etiology*; D012598:Sclerosis
chemical_list: D005938:Glucocorticoids; D007074:Immunoglobulin G
keywords: IgG4; Inflammation; Neoplasm; Orbit; Sclerosing