title: Hydrophobic lappaconitine loaded into iota-carrageenan by one step self-assembly.
abstract: New data on the loading of pH-sensitive lappaconitine loaded into iota-carrageenan (LA-ICG) is provided. This LA-ICG ionic biopolymer was prepared by one step self-assembly. The LA-ICG was characterized in terms of the loading capacity, lappaconitine (LA) releasing behavior, pH-sensitivity, and analgesic properties. Iota-carrageenan (ICG) high loading capacity reached up to 26.18% (w/w). Also, the LA, loaded with ICG, was released faster in an acidic environment than that in neutral or alkaline environments. Animal analgesic experiments showed that the LA-ICG of low molecular weight had earlier onset time and longer duration than the LA. These results suggest that the ICG of low molecular weight has great potential to achieve the synergistic effect of LA. In addition, the ICG can be used as a novel natural polymeric carrier for loading a hydrophobic alkaloid.
authors.affiliation: College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018 China; Department of Agricultural, Food and Nutritional Science (AFNS), University of Alberta, T6G 2P5 Edmonton, AB, Canada; College of life sciences, Northwest Normal University, Lanzhou 730070 China. Electronic address: wenxiu_sun@imau.edu.cn.
authors.forename: Wenxiu
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of Agricultural, Food and Nutritional Science (AFNS), University of Alberta, T6G 2P5 Edmonton, AB, Canada.
authors.forename: Marleny D A
authors.initials: MDA
authors.lastname: Saldaña
authors.affiliation: Department of Agricultural, Food and Nutritional Science (AFNS), University of Alberta, T6G 2P5 Edmonton, AB, Canada.
authors.forename: Yujia
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018 China; Department of Agricultural, Food and Nutritional Science (AFNS), University of Alberta, T6G 2P5 Edmonton, AB, Canada.
authors.forename: Lingling
authors.initials: L
authors.lastname: Wu
authors.affiliation: College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018 China.
authors.forename: Tungalag
authors.initials: T
authors.lastname: Dong
authors.affiliation: College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018 China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Jin
authors.affiliation: College of life sciences, Northwest Normal University, Lanzhou 730070 China.
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
keywords: Analgesic property; Drug release; Iota-carrageenan; Lappaconitine; Self-assembly