title: Association between Estrogen Receptor-α Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility: A Meta-Analysis.
abstract: BACKGROUND
  Certain studies have previously explored the association between the estrogen receptor-α (ER-α) gene polymorphisms and periodontitis susceptibility, although the current results are controversial. The present study, using meta-analysis, aimed to investigate the nature of the genetic susceptibility of the ER-α for developing periodontitis.
  
  
  METHODS
  A comprehensive literature search of PubMed, Embase, CNKI, and Wanfang databases was conducted up to January 8, 2015. Statistical manipulation was performed using Stata version 13.0 software. Odds ratios (ORs) and corresponding 95% confident intervals (CIs) were calculated to estimate the association in five genetic models.
  
  
  RESULTS
  A total of 17 eligible case-control studies from seven identified publications consisting of nine studies for the XbaI polymorphism and eight studies for the PvuII polymorphism were included in the meta-analysis. We found elevated risk of periodontitis in XbaI XX genotype carriers. Moreover, subgroup analyses demonstrated increased risk for chronic periodontitis of XbaI XX genotype carriers, specifically in the Chinese Han female population. No significant association was observed between PvuII polymorphism and periodontitis.
  
  
  CONCLUSIONS
  Current evidence indicated that the homozygote (XX) genotype of ER-α gene XbaI polymorphism, but not PvuII mutation, may increase the risk of chronic periodontitis, specifically in the Chinese Han female population.
authors.affiliation: Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China ; Institute of Medicine and Nursing, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Weng
authors.affiliation: Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Hu
authors.affiliation: Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Rui-Xia
authors.initials: RX
authors.lastname: Yuan
authors.affiliation: Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Zuo
authors.affiliation: Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China ; Institute of Medicine and Nursing, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Jin-Zhu
authors.initials: JZ
authors.lastname: Yan
authors.affiliation: Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China ; Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Niu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D006720:Homozygote; D006801:Humans; D008297:Male; D010518:Periodontitis / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D047628:Estrogen Receptor alpha