title: Toll-like receptors, triggering receptor expressed on myeloid cells family members and receptor for advanced glycation end-products in allergic airway inflammation.
abstract: Asthma is a chronic disorder of the airways characterized by cellular infiltration, airway hyper-responsive and airway inflammation. Innate immune cells are the first line of defense against endogenous and exogenous signals in the airways and as such possess a diverse array of pattern recognition receptors. Toll-like receptors are crucial sentinels which when activated, can either promote or ameliorate the inflammatory response in predisposed individuals. The recently discovered triggering receptor expressed on myeloid cells family members are emerging mediators of inflammation. These receptors are believed to modulate inflammatory responses by collaborating with classic PRRs. Endogenous signals like HMGB-1, signaling through the receptor for advanced glycation end products, also promotes inflammation, however, its contribution to inflammation in the airways is not well known. Here, we discuss the role of each receptor in airway inflammation and highlight potential synergistic mechanisms, which contribute to disease pathogenesis in allergic asthma.
authors.affiliation: a Department of Biomedical Science , Creighton University School of Medicine , Omaha , NE , USA.
authors.forename: Sannette C
authors.initials: SC
authors.lastname: Hall
authors.affiliation: a Department of Biomedical Science , Creighton University School of Medicine , Omaha , NE , USA.|b Department of Medical Microbiology and Immunology , Creighton University School of Medicine , Omaha , NE , USA.|c Department of Clinical and Translational Science , Creighton University School of Medicine , Omaha , NE , USA.
authors.forename: Devendra K
authors.initials: DK
authors.lastname: Agrawal
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000503:physiopathology; D017127:Glycation End Products, Advanced / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000503:physiopathology; D022423:Myeloid Cells / Q000276:immunology*; D000067759:Receptor for Advanced Glycation End Products / Q000502:physiology*; D051193:Toll-Like Receptors / Q000502:physiology*
chemical_list: D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D051193:Toll-Like Receptors
keywords: Allergic airway inflammation; DAP12; HMGB-1; NF-κB; RAGE; TLR; TREM; asthma