title: Identification of new pyrrole alkaloids from the fruits of Lycium chinense.
abstract: Three new minor pyrrole alkaloids, 3-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]pentanedioic acid (1), (2R)-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-1-methoxy-1-oxobutanoic acid (2), and methyl (2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-4-methylpentanoate (3) were isolated from the fruits of Lycium chinense Miller (Solanaceae), along with the known compound, methyl (2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-3-(phenyl)propanoate (4). The structures of 1-4 were elucidated by analysis of their 1D- and 2D-NMR and HRMS data. The absolute configurations of 2-4, possessing a stereogenic center in each structure, were determined by comparison of their experimental electronic circular dichroism (ECD) with those of calculated ECD values.
authors.affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea.
authors.forename: Ui Joung
authors.initials: UJ
authors.lastname: Youn
authors.affiliation: Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea.
authors.forename: Joo Yun
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea.
authors.forename: Yun-Seo
authors.initials: YS
authors.lastname: Kil
authors.affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea.
authors.forename: Ah-Reum
authors.initials: AR
authors.lastname: Han
authors.affiliation: Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea.
authors.forename: Chong Hak
authors.initials: CH
authors.lastname: Chae
authors.affiliation: Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea.
authors.forename: Shi Yong
authors.initials: SY
authors.lastname: Ryu
authors.affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea. yuny@ewha.ac.kr.
authors.forename: Eun-Kyoung
authors.initials: EK
authors.lastname: Seo
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D002942:Circular Dichroism; D005638:Fruit / Q000737:chemistry; D032305:Lycium / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000470:Alkaloids; D010936:Plant Extracts; D011758:Pyrroles
keywords: Absolute configuration; ECD; Lycium chinense; Pyrrole alkaloid; Solanaceae