title: Occurrence of deoxynivalenol in wheat, Hebei Province, China.
abstract: Analysis of deoxynivalenol (DON) and its metabolites 3-acetyl and 15-acetyldeoxynivalenol (3-ADON and 15-ADON) in wheat flour samples by liquid chromatography-tandem mass spectrometry (LC/MS/MS) during 2011-2013 was conducted. [(13)C15]-DON was used as the internal standard to accomplish as accurate as possible quantitation. Of all wheat samples (n=672), 91.5% were positive for DON, at levels ranging from 2.4 to 1130 μg/kg, with a median value of 154 μg/kg. The DON derivatives (3-Ac-DON, 15-Ac-DON) were far less frequently found and at lower levels than DON. The probable daily intakes (PDI) of DON (0.49 in 2011; 0.86 in 2012; 0.56 in 2013, expressed as μg/kg body weight/day) were all within the PDI of 1.0 μg/kg of bw/day for DON set by Scientific Committee for Food (SCF) in 2002. Still, persistent monitoring of DON is important.
authors.affiliation: Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, PR China.
authors.forename: Yinping
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, PR China.
authors.forename: Liying
authors.initials: L
authors.lastname: Wang
authors.affiliation: Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, PR China.
authors.forename: Fengqi
authors.initials: F
authors.lastname: Chang
authors.affiliation: Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, PR China. Electronic address: yanglixin241@163.com.
authors.forename: Lixin
authors.initials: L
authors.lastname: Yang
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods; D005433:Flour / Q000032:analysis; D006801:Humans; D018570:Risk Assessment; D053719:Tandem Mass Spectrometry / Q000379:methods; D014255:Trichothecenes / Q000032:analysis*; D014908:Triticum / Q000737:chemistry*
chemical_list: D014255:Trichothecenes; C043247:3-acetyldeoxynivalenol; C046760:15-acetyldeoxynivalenol; C007262:deoxynivalenol
keywords: China; Deoxynivalenol; LC/MS/MS; Wheat flour