title: The impact of selected cytokines in the follow-up of normal pressure hydrocephalus.
abstract: Cytokines are widely known mediators of inflammation accompanying many neurodegenerative disorders including normal pressure hydrocephalus (NPH). NPH is caused by impaired cerebrospinal fluid (CSF) reabsorption and treated by surgical shunt insertion. The diagnostics is still complicated and the shunt effect is not durable; after several years, dementia may develop. In the clinical practice, biomarkers support the diagnostics as well as the further time course of many neurodegenerative diseases. Until recently, no reliable biomarker for NPH was evaluated. The attempt of this review was to make a survey concerning cytokines as possible NPH markers. Among all reviewed cytokines, the most promising are CSF IL-10 and IL-33, enabling to follow-up the disease progression and monitoring the effectiveness of the shunt insertion.
authors.affiliation: Department of Steroids and Proteofactors, Institute of Endocrinology, Prague, Czech Republic. lsosvorova@endo.cz.
authors.forename: L
authors.initials: L
authors.lastname: Sosvorova
authors.forename: M
authors.initials: M
authors.lastname: Mohapl
authors.forename: J
authors.initials: J
authors.lastname: Vcelak
authors.forename: M
authors.initials: M
authors.lastname: Hill
authors.forename: J
authors.initials: J
authors.lastname: Vitku
authors.forename: R
authors.initials: R
authors.lastname: Hampl
mesh_terms: D015415:Biomarkers / Q000097:blood; D002557:Cerebrospinal Fluid Shunts / Q000639:trends; D016207:Cytokines / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000097:blood* / Q000175:diagnosis* / Q000601:surgery; D018836:Inflammation Mediators / Q000097:blood
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators