title: Modification of surface/neuron interfaces for neural cell-type specific responses: a review.
abstract: Surface/neuron interfaces have played an important role in neural repair including neural prostheses and tissue engineered scaffolds. This comprehensive literature review covers recent studies on the modification of surface/neuron interfaces. These interfaces are identified in cases both where the surfaces of substrates or scaffolds were in direct contact with cells and where the surfaces were modified to facilitate cell adhesion and controlling cell-type specific responses. Different sources of cells for neural repair are described, such as pheochromocytoma neuronal-like cell, neural stem cell (NSC), embryonic stem cell (ESC), mesenchymal stem cell (MSC) and induced pluripotent stem cell (iPS). Commonly modified methods are discussed including patterned surfaces at micro- or nano-scale, surface modification with conducting coatings, and functionalized surfaces with immobilized bioactive molecules. These approaches to control cell-type specific responses have enormous potential implications in neural repair.
authors.affiliation: Bio-X Center, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, People's Republic of China.
authors.forename: Cen
authors.initials: C
authors.lastname: Chen
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Kong
authors.forename: In-Seop
authors.initials: IS
authors.lastname: Lee
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D004867:Equipment Design; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry; D009416:Nerve Regeneration / Q000502:physiology; D058953:Neural Stem Cells / Q000166:cytology* / Q000502:physiology* / Q000637:transplantation; D013499:Surface Properties; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials