title: Adenoid cystic carcinoma of the minor salivary glands: a retrospective series of 29 cases and review of the literature.
abstract: OBJECTIVE
  Approximately 78% of minor salivary gland tumors are malignant, of which adenoid cystic carcinoma (ACC) represents 15% in our series. ACC is an uncommon tumor characterized by slow growth and a high potential for recurrence. This series of 29 consecutive patients examines clincopathologic features, management, and survival outcomes.
  
  
  METHODS
  This study is a retrospective chart review of 29 patients with ACC of the minor salivary glands in a period of 23 years (1989 and 2012).
  
  
  RESULTS
  The mean age was 61.2 years (16-89 years), with no gender predilection. The majority occurred in the palate/maxilla (66%) and initial presentation was stage IV. Mean follow-up was 42.6 months. Recurrence rate was 10% local, 14% distant over the observation period.
  
  
  CONCLUSIONS
  The palate/maxilla is the preferred location for occurrence, and initial presentation at stage IV is common. Postoperative radiation remains a common strategy to prevent local recurrence in lesions with adverse features.
authors.affiliation: Assistant Professor, Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center, Houston, TX, USA. Electronic address: Jonathan.shum@uth.tmc.edu.
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Shum
authors.affiliation: Assistant Professor, Department of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Chatzistefanou
authors.affiliation: Assistant Professor, Department of Oral and Maxillofacial Surgery, University of Mississippi, Jackson, MS, USA.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Qaisi
authors.affiliation: Assistant Professor and Fellowship Director Oral, Head and Neck Surgery/Microvascular Surgery, Department of Oral and Maxillofacial Surgery, University of Maryland School of Dentistry and Greenebaum Cancer Center, Baltimore, MD, USA.
authors.forename: Joshua E
authors.initials: JE
authors.lastname: Lubek
authors.affiliation: Professor and Chair, Department of Oral and Maxillofacial Surgery, University of Maryland School of Dentistry and Greenebaum Cancer Center, Baltimore, MD, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Ord
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008396:Maryland; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000473:pathology* / Q000628:therapy*; D012470:Salivary Glands, Minor / Q000473:pathology*; D015996:Survival Rate; D016896:Treatment Outcome