title: Treatment Outcome of Brain Metastasis after the Cranial Radiotherapy Followed by Fractionated Stereotactic Radiotherapy and Its Prognostic Factors.
abstract: OBJECTIVE
  To evaluate the effectiveness of whole brain radiotherapy followed by stereotactic radiotherapy for newly diagnosed brain metastasis.
  
  
  METHODS
  Thirty-three metastatic brain tumors received radiotherapy to the whole brain and stereotactic radiotherapy in 25 patients. Lung carcinomas were the most common (17/25) primary tumor. The radiation dose was 30 to 40 Gy for the whole brain, with a 12 to 40 Gy boost to the metastatic foci. Survival and local control rates were determined, and the prognostic factors for survival were evaluated.
  
  
  RESULTS
  The overall median survival was 15 months and the actuarial survivals at 1- and 2-year were 67% and 31%, respectively. The local tumor control rate was 79%, with a median follow-up period of 9 months (2~36 months). The prognostic factors associated with survival were age, tumor size and the existence of active extracranial metastasis, with the performance status showing marginal significance. No acute or chronic complications were observed in the patients.
  
  
  CONCLUSIONS
  From our data, cranial radiotherapy followed by stereotactic radiotherapy was useful in the local control of metastatic tumors, and in the survival of patients with tumor factors, such as small size or the absence of extracranial tumor activity, and host factors, such as young age or good performance status.
authors.forename: Hak Jae
authors.initials: HJ
authors.lastname: Kim
authors.forename: Semie
authors.initials: S
authors.lastname: Hong
authors.forename: Suzy
authors.initials: S
authors.lastname: Kim
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Il Han
authors.initials: IH
authors.lastname: Kim
authors.forename: Charn Il
authors.initials: CI
authors.lastname: Park
authors.forename: Sung Whan
authors.initials: SW
authors.lastname: Ha
authors.forename: Hong Gyun
authors.initials: HG
authors.lastname: Wu
authors.forename: Wee Saing
authors.initials: WS
authors.lastname: Kang
keywords: Brain metastasis; Cranial radiotherapy; Prognostic factor; Stereotactic radiotherapy