title: Solitary Rectal Ulcer Syndrome: Demographic, Clinical, Endoscopic and Histological Panorama.
abstract: OBJECTIVE
  To assess the demographic, clinical, endoscopic and histological spectrum of Solitary Rectal Ulcer Syndrome (SRUS).
  
  
  METHODS
  Cross-sectional observational study.
  
  
  METHODS
  Medical Unit-III, Civil Hospital Karachi (CHK) and Ward 7, Jinnah Postgraduate Medical Centre (JPMC), Karachi, from January 2009 to June 2012.
  
  
  METHODS
  Patients with SRUS, based on characteristic endoscopic and histological findings, were enrolled. Patients were excluded if they had other causes of the rectal lesions (neoplasm, infection, inflammatory bowel disease, and trauma). Endoscopically, lesions were divided on the basis of number (solitary or multiple) and appearance (ulcerative, polypoidal/nodular or erythematous mucosa). Demographic, clinical and endoscopic characteristics of subjects were evaluated.
  
  
  RESULTS
  Forty-four patients met the inclusion criteria; 21 (47.7%) were females and 23 (52.3%) were males with overall mean age of 33.73 &plusmn;13.28 years. Symptom-wise 41 (93.2%) had bleeding per rectum, 39 (88.6%) had mucous discharge, 34 (77.3%) had straining, 34 (77.3%) had constipation, 32 (72.7%) had tenesmus, 5 (11.4%) had rectal prolapse and 2 (4.5%) had fecal incontinence. Twelve (27.27%) patients presented with hemoglobin less 10 gm/dl, 27 (61.36%) with 10 - 12 gm/dl and 05 (11.36%) subjects had hemoglobin more than 12 gm/dl. Endoscopically, 26 (59.1%) patients had mucosal ulceration, 11 (25.0%) had mucosal ulceration with polypoid characteristics; while only polypoid features were found in 7 (15.9%) subjects.
  
  
  CONCLUSIONS
  Solitary rectal ulcer syndrome affects adults of both genders with diverse clinical presentation and nonspecific endoscopic features.
authors.affiliation: Department of Medicine, Medical Unit III, Jinnah Postgraduate Medical Centre (JPMC), Karachi.
authors.forename: Amanullah
authors.initials: A
authors.lastname: Abbasi
authors.affiliation: Department of Medicine, Medical Unit III, Jinnah Postgraduate Medical Centre (JPMC), Karachi.
authors.forename: Abdul Rabb
authors.initials: AR
authors.lastname: Bhutto
authors.affiliation: Department of Medicine II, Indus Hospital, Karachi.
authors.forename: Ali
authors.initials: A
authors.lastname: Taj
authors.affiliation: Department of Medicine, Medical Unit III, Jinnah Postgraduate Medical Centre (JPMC), Karachi.
authors.lastname: Aurangzaib
authors.affiliation: Department of Medicine, Medical Unit III, Jinnah Postgraduate Medical Centre (JPMC), Karachi.
authors.forename: Akhtar
authors.initials: A
authors.lastname: Baloch
authors.affiliation: Department of Medicine, Medical Unit III, Jinnah Postgraduate Medical Centre (JPMC), Karachi.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Masroor
authors.affiliation: Department of Medicine, United Hospital, Karachi.
authors.forename: S M
authors.initials: SM
authors.lastname: Munir
mesh_terms: D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D003248:Constipation; D003430:Cross-Sectional Studies; D003710:Demography; D004724:Endoscopy / Q000379:methods*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D012002:Rectal Diseases / Q000175:diagnosis* / Q000188:drug therapy; D012959:Socioeconomic Factors; D013577:Syndrome; D014456:Ulcer / Q000175:diagnosis* / Q000188:drug therapy; D055815:Young Adult
chemical_list: D000897:Anti-Ulcer Agents