title: The Effects of RANTES Polymorphisms on Susceptibility to HIV-1 Infection and Disease Progression: Evidence from an Updated Meta-Analysis.
abstract: Associations of regulated on activation, normal T cell expressed and secreted (RANTES) -403G/A, -28C/G, and In1.1T/C polymorphisms with HIV-1 infection and the progression of HIV-1 disease have been widely reported with inconsistent results. To clarify this situation, we performed an updated meta-analysis of all available studies from PubMed, EMBASE, and the China National Knowledge Infrastructure. A total of 24 eligible studies involving more than 10,000 subjects were included. By using the healthy controls, we found that -403G/A polymorphism was significantly associated with reduced susceptibility to HIV-1 infection in G/A+A/A versus GG (odds ratio [OR] = 0.755, 95% confidence interval [CI] = 0.581-0.982); and a significantly decreased risk was also found for -28C/G polymorphisms (G vs. C, OR = 0.804, 95% CI = 0.696-0.927; G/G+C/G vs. C/C, OR = 0.826, 95% CI = 0.704-0.969). Whereas for In1.1T/C polymorphism, increased risk of HIV-1 infection was revealed (C vs. T, OR = 1.216, 95% CI = 1.047-1.430; T/C vs. T/T, OR = 1.68, 95% CI = 1.263-2.234; T/C+T/T vs. C/C, OR = 1.466, 95% CI = 1.147-1.875). Subgroup analyses by ethnicity showed significant association among Asians, but not among Caucasians. When HIV-1-exposed seronegative (HESN) controls were used, no significant association was detected. Moreover, -403G/A and -28C/G polymorphisms were also not associated with long-term nonprogressive HIV-1 infection (all p > .05). This meta-analysis suggests that RANTES -403G/A and -28C/G polymorphisms confer possible protection against HIV-1 infection, whereas In1.1T/C polymorphism may increase risk of HIV-1 infection, especially in Asians. These results may contribute to finding a theoretical basis for effective control strategies against HIV/AIDS. Further investigations are needed to validate our conclusions.
authors.affiliation: 1 Department of Clinical Laboratory, the Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region , Nanning, Guangxi, China .|2 Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi, China .
authors.forename: Jiangyang
authors.initials: J
authors.lastname: Zhao
authors.affiliation: 1 Department of Clinical Laboratory, the Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region , Nanning, Guangxi, China .
authors.forename: Shangyang
authors.initials: S
authors.lastname: She
authors.affiliation: 2 Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi, China .
authors.forename: Li
authors.initials: L
authors.lastname: Xie
authors.affiliation: 1 Department of Clinical Laboratory, the Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region , Nanning, Guangxi, China .
authors.forename: Xiaopei
authors.initials: X
authors.lastname: Chen
authors.affiliation: 2 Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi, China .
authors.forename: Cuiju
authors.initials: C
authors.lastname: Mo
authors.affiliation: 2 Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi, China .
authors.forename: Li
authors.initials: L
authors.lastname: Huang
authors.affiliation: 3 Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention , Nanning, Guangxi, China .
authors.forename: Wenqian
authors.initials: W
authors.lastname: Tang
authors.affiliation: 2 Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University , Nanning, Guangxi, China .
authors.forename: Xuejie
authors.initials: X
authors.lastname: Chen
mesh_terms: D018946:Chemokine CCL5 / Q000235:genetics*; D002681:China; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: C483024:CCL5 protein, human; D018946:Chemokine CCL5