title: G-protein Coupled Receptor Signaling in Pluripotent Stem Cell-derived Cardiovascular Cells: Implications for Disease Modeling.
abstract: Human pluripotent stem cell derivatives show promise as an in vitro platform to study a range of human cardiovascular diseases. A better understanding of the biology of stem cells and their cardiovascular derivatives will help to understand the strengths and limitations of this new model system. G-protein coupled receptors (GPCRs) are key regulators of stem cell maintenance and differentiation and have an important role in cardiovascular cell signaling. In this review, we will therefore describe the state of knowledge concerning the regulatory role of GPCRs in both the generation and function of pluripotent stem cell derived-cardiomyocytes, -endothelial, and -vascular smooth muscle cells. We will consider how far the in vitro disease models recapitulate authentic GPCR signaling and provide a useful basis for discovery of disease mechanisms or design of therapeutic strategies.
authors.affiliation: Myocardial Function, National Heart and Lung Institute, Imperial College London London, UK.
authors.forename: Nazanin F
authors.initials: NF
authors.lastname: Dolatshad
authors.affiliation: Myocardial Function, National Heart and Lung Institute, Imperial College London London, UK.
authors.forename: Nicola
authors.initials: N
authors.lastname: Hellen
authors.affiliation: Myocardial Function, National Heart and Lung Institute, Imperial College London London, UK.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Jabbour
authors.affiliation: Myocardial Function, National Heart and Lung Institute, Imperial College London London, UK.
authors.forename: Sian E
authors.initials: SE
authors.lastname: Harding
authors.affiliation: Myocardial Function, National Heart and Lung Institute, Imperial College London London, UK ; The Heart and Vascular Center of Semmelweis University, Semmelweis University Budapest, Hungary.
authors.forename: Gabor
authors.initials: G
authors.lastname: Földes
keywords: G-protein coupled receptor; Pluripotent stem cells; cardiovascular; disease modeling