title: Guar gum succinate as a carrier for colon-specific drug delivery.
abstract: A novel type of pH-sensitive colon-specific controlled drug delivery carrier based on guar gum succinate (GGS) was prepared by reacting guar gum (GG) with succinic anhydride (SA) in the presence of 4-dimethylaminopyridine (DMAP). The formation of GGS was confirmed by FT-IR and (1)H NMR and characterized using XRD techniques. GGS microparticles with 460-740 μm in size were prepared using sodium trimetaphosphate (STMP) as a cross-linking agent. The size and morphologies of GGS microparticles were assessed by scanning electron microscopy (SEM). The swelling degree of the GGS microparticles was found to be higher in pH 7.4 than in pH 1.2. In addition, GGS microparticles showed a pH dependent drug release profile when compared to the GG microparticles. The MTT assay revealed that there is no apparent cytotoxicity of GGS against a mouse mesenchymal stem cell line at a concentration range of 0-200 μg/ml. These results confirm that GGS could be used as a carrier for colon-specific drug delivery.
authors.affiliation: Department of Chemistry, Hindustan Institute of Technology and Science, Padur, Chennai 603 103, India.
authors.forename: D Sathya
authors.initials: DS
authors.lastname: Seeli
authors.affiliation: Department of Chemistry, Hindustan Institute of Technology and Science, Padur, Chennai 603 103, India. Electronic address: mprabaharan@yahoo.com.
authors.forename: M
authors.initials: M
authors.lastname: Prabaharan
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003106:Colon / Q000187:drug effects* / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005685:Galactans / Q000737:chemistry*; D007052:Ibuprofen / Q000008:administration & dosage; D008351:Mannans / Q000737:chemistry*; D051379:Mice; D053149:Plant Gums / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D019802:Succinic Acid / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D019802:Succinic Acid; C007894:guar gum; D007052:Ibuprofen
keywords: Colon specific; Cytotoxicity; Drug delivery; Guar gum; Microparticles