title: 20D-dynamic representation of protein sequences.
abstract: A new method of comparison of protein sequences has been formulated. The sequence of amino acids is represented by a set of point masses in a 20D space. The distribution of points in the space is obtained by applying the method of a walk in the 20D space. Projections of the 20D representation into 2D or 3D spaces illustrate the distribution of particular amino acids along the sequence. 20D moments of inertia are proposed as new descriptors of protein sequences.
authors.affiliation: Department of Radiological Informatics and Statistics, Medical University of Gdańsk, Tuwima 15, 80-210 Gdańsk, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Czerniecka
authors.affiliation: Department of Radiological Informatics and Statistics, Medical University of Gdańsk, Tuwima 15, 80-210 Gdańsk, Poland. Electronic address: djwaz@gumed.edu.pl.
authors.forename: Dorota
authors.initials: D
authors.lastname: Bielińska-Wąż
authors.affiliation: Department of Nuclear Medicine, Medical University of Gdańsk, Tuwima 15, 80-210 Gdańsk, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Wąż
authors.affiliation: Computer-Chemie-Centrum and Interdisciplinary Center for Molecular Materials, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nägelsbachstrasse 25, 91052 Erlangen, Germany.
authors.forename: Tim
authors.initials: T
authors.lastname: Clark
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D056004:Molecular Dynamics Simulation; D011487:Protein Conformation; D020539:Sequence Analysis, Protein / Q000379:methods*
keywords: Alignment-free methods; Descriptors; Moments of inertia; Similarity/dissimilarity analysis of protein sequences