title: Histological Spectrum of Large Intestinal Lesions with Clinicopathological Correlation.
abstract: BACKGROUND
  Large intestine is affected by various types of lesions, both non-neoplastic and neoplastic. Due to vague symptoms, the clinical diagnosis is usually delayed. A battery of laboratory tests including biopsy is essential to arrive at a specific diagnosis for appropriate management.
  
  
  METHODS
  This five years study was done during the period of 2005 to 2010 in a tertiary care centre which included 124 biopsies and resected specimens of large intestine and 64 from Anal canal. All tissues were fixed in formalin, stained with H&E and special stains like Periodic Acid Schiff (PAS), Reticulin, Zeihl Neelsen (ZN) along with Immunohistochemistry (IHC) were done as and when required.
  
  
  RESULTS
  Out of the 124 cases of large intestine 38 were non-neoplastic, 77 were neoplastic and 9 were inadequate biopsies. Sixty four cases from Anal canal included 55 non-neoplastic and 9 neoplastic lesions. The non-neoplastic conditions included congenital anomalies, infective and ischaemic lesions while neoplastic included benign and malignant lesions. Most of the cases presented with symptoms like abdominal pain, vomiting and constipation.
  
  
  CONCLUSIONS
  We observed that neoplastic lesions were more common in large intestine while non-neoplastic lesions were frequently seen in Anal canal. Present study emphasizes the need for early histopathological diagnosis for appropriate treatment.
authors.affiliation: Assistant Professor, Department of Pathology, Bidar Institute of Medical Sciences , Bidar, India .
authors.forename: Ritesh
authors.initials: R
authors.lastname: Sulegaon
authors.affiliation: Assistant Professor, Department of Pathology, Dr. V.M. Govt. Medical College , Solapur, India .
authors.forename: Smita
authors.initials: S
authors.lastname: Shete
authors.affiliation: Associate Professor, Department of Pathology, Bidar Institute of Medical Sciences , Bidar, India .
authors.forename: Dinesh
authors.initials: D
authors.lastname: Kulkarni
keywords: Congenital anomalies; Inflammatory; Ischaemic; Neoplastic