title: Is arterial stiffness predicted by continuous metabolic syndrome score in obese children?
abstract: The aim of the article was to evaluate arterial stiffness, an early marker of increased cardiovascular risk, in relation to obesity. The continuous metabolic syndrome (cMetS) score was calculated as sum of Z score of mean arterial pressure, body mass index, serum glucose, triglyceride, and high-density lipoprotein cholesterol in 144 obese patients and 66 nonobese controls. Ambulatory arterial stiffness index (AASI) was calculated as 1 minus regression slope of diastolic on systolic blood pressure from ambulatory blood pressure measurements. The mean AASI increased progressively with severity of obesity. The receiver operator curve analysis of body mass index and AASI showed area under the curve of 0.64 ± 0.06; cMetS area under the curve was 0.72 ± 0.05 suggesting a better predictive power of the cMetS for an increased AASI (>0.3). Patients with obesity have significantly higher arterial stiffness. A composite score such as cMetS seems to be better predictor of an increased stiffness than individual risk factors.
authors.affiliation: 2(nd) Department of Pediatrics, Comenius University Medical School, University Children's Hospital, Bratislava, Slovakia. Electronic address: katka.prochotska@gmail.com.
authors.forename: Katarina
authors.initials: K
authors.lastname: Prochotska
authors.affiliation: 2(nd) Department of Pediatrics, Comenius University Medical School, University Children's Hospital, Bratislava, Slovakia.
authors.forename: Laszlo
authors.initials: L
authors.lastname: Kovacs
authors.affiliation: 2(nd) Department of Pediatrics, Comenius University Medical School, University Children's Hospital, Bratislava, Slovakia.
authors.forename: Eva
authors.initials: E
authors.lastname: Vitariusova
authors.affiliation: Division of Nephrology, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada.
authors.forename: Janusz
authors.initials: J
authors.lastname: Feber
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D015992:Body Mass Index; D002170:Canada / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D011237:Predictive Value of Tests; D012107:Research Design; D012307:Risk Factors; D012720:Severity of Illness Index; D013223:Statistics as Topic; D014280:Triglycerides / Q000097:blood; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D014280:Triglycerides
keywords: Arterial stiffness index; continuous metabolic syndrome; hypertension; obesity