title: Gastrointestinal motility during sleep assessed by tracking of telemetric capsules combined with polysomnography - a pilot study.
abstract: Studies of gastrointestinal function during sleep are hampered by lack of applicable techniques. Recent development of a novel ambulatory telemetric capsule system, which can be used in conjunction with polysomnography, offers a solution to this problem. The 3D-Transit system consists of ingestible electromagnetic capsules traceable through a portable extracorporeal receiver while traversing the gut. During sleep monitored by polysomnography, gastrointestinal motility was concurrently investigated using 3D-Transit in nine healthy subjects. Overall, the amplitude of gastric contractions decreased with depth of sleep (light sleep, N2 versus deep sleep, N3; P<0.05). Progression through the small intestine did not change with depth of sleep (Kruskal-Wallis probability =0.1), and there was no association between nocturnal awakenings or arousals and the occurrence of colonic or small intestinal propagating movements. Basal colonic activity was suppressed during both deep sleep (P<0.05) and light sleep (P<0.05) when compared with nocturnal wake periods. In conclusion, the novel ambulatory 3D-Transit system combined with polysomnography allows minimally invasive and completely ambulatory investigation of associations between sleep patterns and gastrointestinal motility.
authors.affiliation: Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Anne-Mette
authors.initials: AM
authors.lastname: Haase
authors.affiliation: Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
authors.forename: Sibylle
authors.initials: S
authors.lastname: Fallet
authors.affiliation: Department of Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Marit
authors.initials: M
authors.lastname: Otto
authors.affiliation: Neurogastroenterology Group, Gastrointestinal Physiology Unit, Queen Mary University, London, UK.
authors.forename: S Mark
authors.initials: SM
authors.lastname: Scott
authors.affiliation: Motilis Medica SA, Lausanne, Switzerland.
authors.forename: Vincent
authors.initials: V
authors.lastname: Schlageter
authors.affiliation: Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Klaus
authors.initials: K
authors.lastname: Krogh
keywords: circadian motility; colonic movement; gastric contractions; ingestible capsule; sleep assessment; sleep stage