title: Proposal of thermal imaging application in photodynamic therapy-Preliminary report.
abstract: There are many different skin lesions that manifest a skin temperature gradient. Basal cell carcinoma (BCC) is the most frequently occurring type of malignant skin lesion (almost 95% of all skin tumors). BCC is sometimes treated by using photodynamic therapy which is very well tolerated by patients and provides good results, especially in superficial skin layer lesions. The results of our studies showed significant changes in the area of temperature gradient due to photodynamic therapy. It seems that the ability to acquire knowledge of such area changes may provide additional useful information to physicians. The increase of observed isotherm area in comparison to lesion size on the skin was a few times higher. It may suggest the range of areas where the metabolism processes take place. Due to the accumulation of photosensitivity only in tumor cells, we theorize that such a large region of increased metabolism observed during therapy may be connected with a larger range of tumor cells than was previously predicted through diagnosis. However, it should be noted that the region can be much bigger due to the existing heat transfer. The results obtained have a potential meaning in describing the range of chemical and physiological processes occurring during photodynamic therapy.
authors.affiliation: A. Chełkowski Institute of Physics, Department of Medical Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland. Electronic address: armand.cholewka@gmail.com.
authors.forename: Armand
authors.initials: A
authors.lastname: Cholewka
authors.affiliation: School of Medicine with the Division of Dentistry in Zabrze, Department and Clinic of Internal Diseases, Angiology and Physical Medicine in Bytom, Medical University of Silesia, Batorego Street 15, 41-902 Bytom, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Stanek
authors.affiliation: School of Medicine with the Division of Dentistry in Zabrze, Department and Clinic of Internal Diseases, Angiology and Physical Medicine in Bytom, Medical University of Silesia, Batorego Street 15, 41-902 Bytom, Poland.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kwiatek
authors.affiliation: Radiotherapy and Brachytherapy Planning Department, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Wybrzeże Armii Krajowej 15, Gliwice, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Cholewka
authors.affiliation: School of Medicine with the Division of Dentistry in Zabrze, Department and Clinic of Internal Diseases, Angiology and Physical Medicine in Bytom, Medical University of Silesia, Batorego Street 15, 41-902 Bytom, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Cieślar
authors.affiliation: School of Medicine with the Division of Dentistry in Zabrze, Department and Clinic of Internal Diseases, Angiology and Physical Medicine in Bytom, Medical University of Silesia, Batorego Street 15, 41-902 Bytom, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Straszak
authors.affiliation: A. Chełkowski Institute of Physics, Department of Medical Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Gibińska
authors.affiliation: School of Health Sciences in Katowice, Department of Physical Medicine, Chair of Physiotherapy, Medical University of Silesia, Medyków Street 12, 40-752 Katowice, Poland.
authors.forename: Karolina
authors.initials: K
authors.lastname: Sieroń-Stołtny
mesh_terms: D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D002280:Basal Cell Carcinoma / Q000000981:diagnostic imaging* / Q000628:therapy*; D006801:Humans; D008297:Male; D010778:Photochemotherapy; D012878:Skin Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D012881:Skin Temperature
chemical_list: D000622:Aminolevulinic Acid
keywords: Basal cell carcinoma; Photodynamic diagnosis; Photodynamic therapy; Temperature; Thermovision diagnostics