title: Fucoidan from sea cucumber may improve hepatic inflammatory response and insulin resistance in mice.
abstract: Nutrition excess-induced inflammation positively contributed to insulin resistance. Fucoidan from sea cucumber can increase glucose translocation in skeletal muscle. However, its effects on inflammation-associated insulin resistance are not understood. We investigated fucoidan from Isostichopus badionotus (Ib-FUC)-alleviated inflammatory response and signaling as well as -improved insulin resistance in the liver of obesity mice. The results showed that Ib-FUC reduced body weight and glucose levels, increased insulin sensitivity, and inhibited serum lipid concentrations. Meanwhile, Hepatic glycogen synthesis was promoted by Ib-FUC via activation of the PI3K/PKB/GSK-3β signaling and regulation of glucose metabolism-related enzymatic activities. Ib-FUC regulated serum inflammatory cytokines and their mRNA expression in the liver. Ib-FUC-induced inactivation of the JNK and IKKβ/NFκB pathways was involved in the activation of insulin signal cascade and inflammatory factor production. These findings suggested that Ib-FUC supplementary-induced alleviation of inflammatory response could be a mechanism responsible for its beneficial effects against hepatic insulin resistance.
authors.affiliation: Innovation Application Institute, Zhejiang Ocean University, Zhoushan, Zhejiang Province 316022, China.
authors.forename: Jinhui
authors.initials: J
authors.lastname: Wang
authors.affiliation: Innovation Application Institute, Zhejiang Ocean University, Zhoushan, Zhejiang Province 316022, China; College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province 266003, China. Electronic address: hushiweihai@163.com.
authors.forename: Shiwei
authors.initials: S
authors.lastname: Hu
authors.affiliation: Innovation Application Institute, Zhejiang Ocean University, Zhoushan, Zhejiang Province 316022, China; College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province 266003, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Innovation Application Institute, Zhejiang Ocean University, Zhoushan, Zhejiang Province 316022, China.
authors.forename: Wendong
authors.initials: W
authors.lastname: Song
authors.affiliation: Innovation Application Institute, Zhejiang Ocean University, Zhoushan, Zhejiang Province 316022, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Cai
authors.affiliation: College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province 266003, China.
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D005947:Glucose / Q000378:metabolism; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D009765:Obesity / Q000188:drug therapy* / Q000276:immunology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D011134:Polysaccharides / Q000008:administration & dosage*; D012616:Sea Cucumbers / Q000276:immunology; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D011134:Polysaccharides; C007789:fucoidan; D019869:Phosphatidylinositol 3-Kinases; D005947:Glucose
keywords: Fucoidan; Inflammatory response; Insulin resistance; Sea cucumber