title: Treating appendicitis with antibiotics.
abstract: A nonsurgical approach using antimicrobial agents has been advocated as the initial treatment of uncomplicated appendicitis. Several studies and meta-analyses explored this approach. Because many of these studies included individuals with resolving appendicitis, their results were biased. Antimicrobials, however, are warranted and needed for the management of surgical high-risk patients with perforated appendicitis and those with localized abscess or phlegmon. Randomized placebo-controlled trials that focus on early identification of complicated acute appendicitis patients needing surgery and that prospectively evaluate the optimal use of antibiotic treatment in patients with uncomplicated acute appendicitis are warranted.
authors.affiliation: Department of Pediatrics, Georgetown, University School of Medicine Washington DC. Electronic address: ib6@georgetown.edu.
authors.forename: Itzhak
authors.initials: I
authors.lastname: Brook
mesh_terms: D000038:Abscess / Q000188:drug therapy*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001062:Appendectomy; D001064:Appendicitis / Q000188:drug therapy*; D006801:Humans; D007416:Intestinal Perforation / Q000188:drug therapy*; D012008:Recurrence
chemical_list: D000900:Anti-Bacterial Agents