title: Triglyceride-Lowering Effects of Two Probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia.
abstract: The triglyceride-lowering effect of probiotics Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 were investigated. Male SD Wistar rats were randomly divided into three groups and fed high-fat diet (HFD), HFD and probiotics (5 X 10(9) CFU/day of L. plantarum KY1032 and 5 X 10(9) CFU/day of L. curvatus HY7601), or normal diet for 6 weeks. Probiotic treatment significantly lowered the elevated plasma triglyceride and increased plasma free fatty acid, glycerol, and plasma apolipoprotein A-V (ApoA-V) levels. The probiotic-treated group showed elevated hepatic mRNA expression of PPARα, bile acid receptor (FXR), and ApoA-V. These results demonstrate that L. plantarum KY1032 and L. curvatus HY7601 lower triglycerides in hypertriglyceridemic rats by upregulating ApoA-V, PPARα, and FXR.
authors.affiliation: Korea Yakult Co., Ltd., Yongin 17086, Republic of Korea.
authors.forename: Il-Dong
authors.initials: ID
authors.lastname: Choi
authors.affiliation: Korea Yakult Co., Ltd., Yongin 17086, Republic of Korea.
authors.forename: Sung-Hwan
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Korea Yakult Co., Ltd., Yongin 17086, Republic of Korea.
authors.forename: Ji-Woong
authors.initials: JW
authors.lastname: Jeong
authors.affiliation: Korea Yakult Co., Ltd., Yongin 17086, Republic of Korea.
authors.forename: Dong Eun
authors.initials: DE
authors.lastname: Lee
authors.affiliation: Graduate School of International Agricultural Technology, Institute of Green Bio Science & Technology, Seoul National University, Pyeongchang 25354, Republic of Korea.
authors.forename: Chul-Sung
authors.initials: CS
authors.lastname: Huh
authors.affiliation: Division of Gastroenterology, Vievis NAMUH Hospital, Seoul 06117, Republic of Korea.
authors.forename: Seong Soo
authors.initials: SS
authors.lastname: Hong
authors.affiliation: Korea Yakult Co., Ltd., Yongin 17086, Republic of Korea.
authors.forename: Jae-Hun
authors.initials: JH
authors.lastname: Sim
authors.affiliation: Korea Yakult Co., Ltd., Yongin 17086, Republic of Korea.
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Ahn
mesh_terms: D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects; D019587:Dietary Supplements; D004195:Disease Models, Animal; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy* / Q000378:metabolism; D007778:Lactobacillus / Q000502:physiology*; D048191:Lactiplantibacillus plantarum / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D008297:Male; D019936:Probiotics / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D014280:Triglycerides
keywords: Lactobacillus curvatus; Lactobacillus plantarum; Triglyceride; apolipoprotein A-V; probiotics