title: Tri-band spectroscopic optical coherence tomography based on optical parametric amplification for lipid and vessel visualization.
abstract: A tri-band spectroscopic optical coherence tomography (SOCT) system has been implemented for visualization of lipid and blood vessel distribution. The tri-band swept source, which covers output spectrum in 1.3, 1.5, and 1.6  μm wavelength windows, is based on a dual-band Fourier domain mode-locked laser and a fiber optical parametric amplifier. This tri-band SOCT can further differentiate materials, e.g., lipid and artery, qualitatively by contrasting attenuation coefficients difference within any two of these bands. Furthermore, ex vivo imaging of both porcine artery with artificial lipid plaque phantom and mice with coronary artery disease were demonstrated to showcase the capability of our SOCT.
authors.affiliation: The University of Hong Kong, Photonic Systems Research Laboratory, Department of Electrical and Electronic Engineering, Pokfulam Road, Hong Kong, China.
authors.forename: Luoqin
authors.initials: L
authors.lastname: Yu
authors.affiliation: The University of Hong Kong, Photonic Systems Research Laboratory, Department of Electrical and Electronic Engineering, Pokfulam Road, Hong Kong, China.
authors.forename: Jiqiang
authors.initials: J
authors.lastname: Kang
authors.affiliation: The University of Hong Kong, Photonic Systems Research Laboratory, Department of Electrical and Electronic Engineering, Pokfulam Road, Hong Kong, China.
authors.forename: Chandra
authors.initials: C
authors.lastname: Jinata
authors.affiliation: The University of Hong Kong, Photonic Systems Research Laboratory, Department of Electrical and Electronic Engineering, Pokfulam Road, Hong Kong, China.
authors.forename: Xie
authors.initials: X
authors.lastname: Wang
authors.affiliation: The University of Hong Kong, Photonic Systems Research Laboratory, Department of Electrical and Electronic Engineering, Pokfulam Road, Hong Kong, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Wei
authors.affiliation: The University of Hong Kong, Department of Surgery, Hong Kong, Pokfulam Road, Hong Kong, China.
authors.forename: Kin Tak
authors.initials: KT
authors.lastname: Chan
authors.affiliation: The University of Hong Kong, Department of Surgery, Hong Kong, Pokfulam Road, Hong Kong, China.
authors.forename: Nikki P
authors.initials: NP
authors.lastname: Lee
authors.affiliation: The University of Hong Kong, Photonic Systems Research Laboratory, Department of Electrical and Electronic Engineering, Pokfulam Road, Hong Kong, China.
authors.forename: Kenneth K Y
authors.initials: KK
authors.lastname: Wong
mesh_terms: D000669:Amplifiers, Electronic; D000818:Animals; D001158:Arteries / Q000473:pathology; D001808:Blood Vessels / Q000033:anatomy & histology*; D004867:Equipment Design; D005260:Female; D005583:Fourier Analysis; D007091:Image Processing, Computer-Assisted; D007834:Lasers; D008055:Lipids / Q000737:chemistry*; D051379:Mice; D008810:Mice, Inbred C57BL; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D012815:Signal Processing, Computer-Assisted; D013053:Spectrophotometry / Q000379:methods*; D013552:Swine; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D008055:Lipids