title: Species sensitivity distribution for chlorpyrifos to aquatic organisms: Model choice and sample size.
abstract: Species sensitivity distribution (SSD) is a widely used model that extrapolates the ecological risk to ecosystem levels from the ecotoxicity of a chemical to individual organisms. However, model choice and sample size significantly affect the development of the SSD model and the estimation of hazardous concentrations at the 5th centile (HC5). To interpret their effects, the SSD model for chlorpyrifos, a widely used organophosphate pesticide, to aquatic organisms is presented with emphases on model choice and sample size. Three subsets of median effective concentration (EC50) with different sample sizes were obtained from ECOTOX and used to build SSD models based on parametric distribution (normal, logistic, and triangle distribution) and nonparametric bootstrap. The SSD models based on the triangle distribution are superior to the normal and logistic distributions according to several goodness-of-fit techniques. Among all parametric SSD models, the one with the largest sample size based on the triangle distribution gives the most strict HC5 with 0.141μmolL(-1). The HC5 derived from the nonparametric bootstrap is 0.159μmol L(-1). The minimum sample size required to build a stable SSD model is 11 based on parametric distribution and 23 based on nonparametric bootstrap. The study suggests that model choice and sample size are important sources of uncertainty for application of the SSD model.
authors.affiliation: College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: jszhao@mail.hzau.edu.cn.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Zhao
authors.affiliation: College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070, China; Suyu District Environmental Monitoring Station, Suqian 223800, China.
authors.forename: Boyu
authors.initials: B
authors.lastname: Chen
mesh_terms: D059001:Aquatic Organisms / Q000187:drug effects*; D004390:Chlorpyrifos / Q000633:toxicity*; D017753:Ecosystem; D008954:Models, Biological; D018570:Risk Assessment; D018401:Sample Size; D013045:Species Specificity
chemical_list: D004390:Chlorpyrifos
keywords: Aquatic organism; Model choice; Organophosphate pesticide; Parametric and nonparametric bootstrap; Sample size; Species sensitivity distribution