title: Abnormal striatal resting-state functional connectivity in adolescents with obsessive-compulsive disorder.
abstract: Neuroimaging research has implicated abnormalities in cortico-striatal-thalamic-cortical (CSTC) circuitry in pediatric obsessive-compulsive disorder (OCD). In this study, resting-state functional magnetic resonance imaging (R-fMRI) was used to investigate functional connectivity in the CSTC circuitry in adolescents with OCD. Imaging was obtained with the Human Connectome Project (HCP) scanner using newly developed pulse sequences which allow for higher spatial and temporal resolution. Fifteen adolescents with OCD and 13 age- and gender-matched healthy controls (ages 12-19) underwent R-fMRI on the 3T HCP scanner. Twenty-four minutes of resting-state scans (two consecutive 12-min scans) were acquired. We investigated functional connectivity of the striatum using a seed-based, whole brain approach with anatomically-defined seeds placed in the bilateral caudate, putamen, and nucleus accumbens. Adolescents with OCD compared with controls exhibited significantly lower functional connectivity between the left putamen and a single cluster of right-sided cortical areas including parts of the orbitofrontal cortex, inferior frontal gyrus, insula, and operculum. Preliminary findings suggest that impaired striatal connectivity in adolescents with OCD in part falls within the predicted CSTC network, and also involves impaired connections between a key CSTC network region (i.e., putamen) and key regions in the salience network (i.e., insula/operculum). The relevance of impaired putamen-insula/operculum connectivity in OCD is discussed.
authors.affiliation: University of Minnesota, Division of Child and Adolescent Psychiatry, F282/2A West, 2450 Riverside Avenue, Minneapolis, MN 55454, USA. Electronic address: berns001@umn.edu.
authors.forename: Gail A
authors.initials: GA
authors.lastname: Bernstein
authors.affiliation: University of Minnesota, Department of Psychiatry, F282/2A West, 2450 Riverside Avenue, Minneapolis, MN 55454, USA. Electronic address: muell093@umn.edu.
authors.forename: Bryon A
authors.initials: BA
authors.lastname: Mueller
authors.affiliation: University of Minnesota, Division of Child and Adolescent Psychiatry, F282/2A West, 2450 Riverside Avenue, Minneapolis, MN 55454, USA. Electronic address: westl110@umn.edu.
authors.forename: Melinda Westlund
authors.initials: MW
authors.lastname: Schreiner
authors.affiliation: University of Minnesota, Division of Child and Adolescent Psychiatry, F282/2A West, 2450 Riverside Avenue, Minneapolis, MN 55454, USA. Electronic address: campb767@umn.edu.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Campbell
authors.affiliation: University of Minnesota, Division of Child and Adolescent Psychiatry, F282/2A West, 2450 Riverside Avenue, Minneapolis, MN 55454, USA. Electronic address: rega0148@umn.edu.
authors.forename: Emily K
authors.initials: EK
authors.lastname: Regan
authors.affiliation: University of Minnesota, Division of Child and Adolescent Psychiatry, F282/2A West, 2450 Riverside Avenue, Minneapolis, MN 55454, USA; Penn State College of Education, Department of Educational Psychology, Counseling, and Special Education, 106 Cedar Building, University Park, PA 16802, USA. Electronic address: pmn12@psu.edu.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Nelson
authors.affiliation: University of Minnesota, Division of Child and Adolescent Psychiatry, F282/2A West, 2450 Riverside Avenue, Minneapolis, MN 55454, USA. Electronic address: houri005@umn.edu.
authors.forename: Alaa K
authors.initials: AK
authors.lastname: Houri
authors.affiliation: University of Minnesota, Division of Child and Adolescent Psychiatry, F282/2A West, 2450 Riverside Avenue, Minneapolis, MN 55454, USA. Electronic address: leexx310@umn.edu.
authors.forename: Susanne S
authors.initials: SS
authors.lastname: Lee
authors.affiliation: University of Minnesota, Division of Child and Adolescent Psychiatry, F282/2A West, 2450 Riverside Avenue, Minneapolis, MN 55454, USA. Electronic address: zagol001@umn.edu.
authors.forename: Alexandra D
authors.initials: AD
authors.lastname: Zagoloff
authors.affiliation: University of Minnesota, Department of Psychiatry, F282/2A West, 2450 Riverside Avenue, Minneapolis, MN 55454, USA. Electronic address: kolim@umn.edu.
authors.forename: Kelvin O
authors.initials: KO
authors.lastname: Lim
authors.affiliation: University of Minnesota, Center for Magnetic Resonance Research, 2021-6th Street SE, Minneapolis, MN 55455, USA. Electronic address: yaco0006@umn.edu.
authors.forename: Essa S
authors.initials: ES
authors.lastname: Yacoub
authors.affiliation: University of Minnesota, Division of Child and Adolescent Psychiatry, F282/2A West, 2450 Riverside Avenue, Minneapolis, MN 55454, USA. Electronic address: rega0026@umn.edu.
authors.forename: Kathryn R
authors.initials: KR
authors.lastname: Cullen
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology; D002648:Child; D003342:Corpus Striatum / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009434:Neural Pathways / Q000473:pathology*; D009714:Nucleus Accumbens / Q000503:physiopathology; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology*; D011699:Putamen / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted; D013788:Thalamus / Q000473:pathology / Q000503:physiopathology*; D055815:Young Adult
keywords: Functional MRI; Insula; Neuroimaging; Operculum; Striatum