title: Biosynthesis of polyketides by trans-AT polyketide synthases.
abstract: This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that represents one of the major group of proteins involved in the production of bioactive polyketides. The article includes 609 references and covers the literature from 2009 through June 2015.
authors.affiliation: Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland. jpiel@ethz.ch.
authors.forename: Eric J N
authors.initials: EJ
authors.lastname: Helfrich
authors.affiliation: Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 1-5/10, 8093 Zurich, Switzerland. jpiel@ethz.ch.
authors.forename: Jörn
authors.initials: J
authors.lastname: Piel
mesh_terms: D001688:Biological Products / Q000378:metabolism*; D006801:Humans; D015394:Molecular Structure; D048630:Polyketide Synthases / Q000378:metabolism*; D061065:Polyketides / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001688:Biological Products; D061065:Polyketides; D048630:Polyketide Synthases