title: Study of the Annexin A1 and Its Associations with Carcinoembryonic Antigen and Mismatch Repair Proteins in Colorectal Cancer.
abstract: OBJECTIVE
  Annexin-A1 (ANXA1) has been implicated in various tumor types, but few studies have investigated its involvement in colorectal cancer. The study aimed to analyze ANXA1 expression in the normal margin and colorectal tumor tissues of 104 patients who underwent surgery for colorectal cancer and to associate the ANXA1 expression with predictive clinicopathological variables.
  
  
  METHODS
  Hematoxylin-eosin and immunohistochemical staining were used for the analysis.
  
  
  RESULTS
  ANXA1 expression was higher in colorectal cancer than in normal margin tissue (p = 0.0001). However, no differences were observed when we analyzed the ANXA1 expression in colon and rectal tumors (p = 0.830). Also, this protein positivity was associated with increased carcinoembryonic antigen levels (p = 0.004). Our data in the DNA-mismatch repair proteins expression was in accordance to the literature. And their positivity was not associated with ANXA1 presence in colorectal cancer.
  
  
  CONCLUSIONS
  The high incidence of ANXA1 positive expression in colorectal cancer and its association with carcinoembryonic antigen levels might indicate the importance of this protein in the colorectal cancer biology.
authors.affiliation: Post-Graduate Program in Health Sciences, Faculty of Medicine (FM), Federal University of Mato Grosso (UFMT), 78060-900, Cuiabá, MT, Brazil. lenuceydy@gmail.com.
authors.forename: Lenuce Ribeiro Aziz
authors.initials: LR
authors.lastname: Ydy
authors.affiliation: Department of Surgery, Faculty of Medicine, UFMT, Cuiabá, MT, Brazil.
authors.forename: Gilmar Ferreira
authors.initials: GF
authors.lastname: do Espírito Santo
authors.affiliation: Post-Graduate Program in Health Sciences, Faculty of Medicine (FM), Federal University of Mato Grosso (UFMT), 78060-900, Cuiabá, MT, Brazil.|Laboratory of Pathology, Faculty of Medicine, University Hospital Júlio Muller, UFMT, Cuiabá, MT, Brazil.
authors.forename: Ivana
authors.initials: I
authors.lastname: de Menezes
authors.affiliation: Undergraduate Course in Medicine, Faculty of Medicine, UFMT, Cuiabá, MT, Brazil.
authors.forename: Michelle Santos
authors.initials: MS
authors.lastname: Martins
authors.affiliation: Post-Graduate Program in Health Sciences, Faculty of Medicine (FM), Federal University of Mato Grosso (UFMT), 78060-900, Cuiabá, MT, Brazil.|Department of Nursing, State University of Mato Grosso (UNEMAT), Cáceres, MT, Brazil.
authors.forename: Eliane
authors.initials: E
authors.lastname: Ignotti
authors.affiliation: Post-Graduate Program in Health Sciences, Faculty of Medicine (FM), Federal University of Mato Grosso (UFMT), 78060-900, Cuiabá, MT, Brazil. asdamazo@yahoo.com.br.|Department of Basic Health Sciences, Faculty of Medicine (FM), Federal University of Mato Grosso (UFMT), 78060-900, Cuiabá, MT, Brazil. asdamazo@yahoo.com.br.
authors.forename: Amílcar Sabino
authors.initials: AS
authors.lastname: Damazo
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017305:Annexin A1 / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002272:Carcinoembryonic Antigen / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D003430:Cross-Sectional Studies; D045643:DNA Repair Enzymes / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D017305:Annexin A1; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D045643:DNA Repair Enzymes
keywords: Annexin A1; Carcinoembryonic antigen levels; Colorectal tumor; Mismatch repair proteins