title: [Clinicopathologic analysis of HIV-negative plasmablastic lymphoma].
abstract: OBJECTIVE
  To study the clinical, pathologic, immunophenotype, molecular characteristics and prognosis of HIV-negative plasmablastic lymphoma (PBL).
  
  
  METHODS
  Twelve cases of HIV-negative PBLs diagnosed between 2005 and 2014 in Guangdong General Hospital were identified according to WHO classification of tumors of haematopoietic and lymphoid tissues (2008). The clinicopathologic features and outcome were analyzed and the relevant literatures were reviewed.
  
  
  RESULTS
  The patients were predominantly male (11/12) with a median age of 55.5 years. The tumor cells showed the characteristic combination of immunoblastic/plasmablastic morphology, plasma cell phenotype and high proliferation, no expression of mature B cell markers. 7/10 of the cases were EBER positive. Two cases were positive for C-myc translocation. Four of twelve patients were died.
  
  
  CONCLUSIONS
  PBL is a rare, aggressive B-cell lymphoma. HIV-negative PBL has lower rate of oral involvement and EBER expression than HIV-positive patients, the differential diagnosis is very challenging, and the prognosis is worse.
authors.affiliation: Department of Pathology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: E-mail: yanh_liu@163.com.
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Liu
authors.forename: Donglan
authors.initials: D
authors.lastname: Luo
authors.forename: Fen
authors.initials: F
authors.lastname: Zhang
authors.forename: Fangping
authors.initials: F
authors.lastname: Xu
authors.forename: Yan
authors.initials: Y
authors.lastname: Ge
authors.forename: Xinlan
authors.initials: X
authors.lastname: Luo
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D018023:HIV Seronegativity; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000145:classification; D000069293:Plasmablastic Lymphoma / Q000175:diagnosis* / Q000473:pathology*; D011379:Prognosis; D014178:Translocation, Genetic