title: Prevalence of hepatitis B and C and sensibility of a selective screening questionnaire in patients receiving chemotherapy for solid tumors.
abstract: BACKGROUND
  Reactivation of hepatitis B or C virus can occur in patients undergoing chemotherapy. Recommendations for selective or systematic hepatitis B virus testing prior chemotherapy for solid tumors differ. The primary aim was to determine the seroprevalence of hepatitis B or C in a low endemic country. The second objective was to assess the relevance of a questionnaire on hepatitis B/C risk factors to consider a selective screening.
  
  
  METHODS
  Patients were prospectively tested for hepatitis B/C markers. HBs antigen positive patients and isolated anti-HBc positive patients with detectable viral load received antiviral preventive treatment. Patients or physicians completed the questionnaire on infection risk factors.
  
  
  RESULTS
  Among the 450 patients included, 388 were tested for all serological markers and had gastrointestinal (63.7%), lung (31.2%) and skin (4.6%) cancers. The prevalence of subjects exposed to hepatitis B virus was 8.5% (33/388). One patient tested positive for HBs antigen and received preventive treatment. Prevalence of subjects exposed to hepatitis C was 1.3% (5/388). The questionnaire sensitivity was 45.5%, 100% and 50% for detecting carriers of hepatitis B, C and one or the other, respectively.
  
  
  CONCLUSIONS
  Seroprevalence of hepatitis B was low. Selective screening with the questionnaire was insufficiently sensitive. Systematic screening with serological tests prior to chemotherapy in patients with solid tumors is therefore relevant.
authors.affiliation: CHU Reims, Hôpital Robert Debré, Structure Interne d'Hépato-Gastro-Entérologie et Cancérologie Digestive, Avenue du Génénal Kœnig, Reims, F-51092, France. mathildebrasseur@gmail.com.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Brasseur
authors.affiliation: CHU Reims, Hôpital Robert Debré, Structure Interne d'Hépato-Gastro-Entérologie et Cancérologie Digestive, Avenue du Génénal Kœnig, Reims, F-51092, France. aheurgue@chu-reims.fr.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Heurgué-Berlot
authors.affiliation: CHU Reims, Hôpital Robert Debré, Unité d'Aide Méthodologique, Avenue du Génénal Kœnig, Reims, F-51092, France. cbarbe@chu-reims.fr.
authors.forename: Coralie
authors.initials: C
authors.lastname: Barbe
authors.affiliation: CHU Reims, Hôpital Robert Debré, Unité de Médecine Ambulatoire Cancérologie Hématologie, Avenue du Génénal Kœnig, Reims, F-51092, France. cloebrami@gmail.com.
authors.forename: Cloé
authors.initials: C
authors.lastname: Brami
authors.affiliation: Institut de Cancérologie Jean Godinot, Département de Pharmacie, Avenue du Génénal Kœnig, Reims, F-51100, France. jean-baptiste.rey@reims.unicancer.fr.|Université de Reims Champagne-Ardenne, Laboratoire EA4691, Avenue du Maréchal Juin, Reims, F-51100, France. jean-baptiste.rey@reims.unicancer.fr.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Rey
authors.affiliation: CHU Reims, Hôpital Maison Blanche, Maladies Respiratoires et Allergologie, Avenue du Génénal Kœnig, Reims, F-51092, France. jvellaboucaud@chu-reims.fr.
authors.forename: Juliette
authors.initials: J
authors.lastname: Vella-Boucaud
authors.affiliation: CHU Reims, Hôpital Robert Debré, Structure interne de Dermatologie, Avenue du Génénal Kœnig, Reims, F-51092, France. dabouz.fadia@gmail.com.
authors.forename: Fadia
authors.initials: F
authors.lastname: Dabouz
authors.affiliation: CHU Reims, Hôpital Maison Blanche, Maladies Respiratoires et Allergologie, Avenue du Génénal Kœnig, Reims, F-51092, France. gdeslee@chu-reims.fr.
authors.forename: Gaëtan
authors.initials: G
authors.lastname: Deslée
authors.affiliation: CHU Reims, Hôpital Robert Debré, Structure interne de Dermatologie, Avenue du Génénal Kœnig, Reims, F-51092, France. fgrange@chu-reims.fr.
authors.forename: Florent
authors.initials: F
authors.lastname: Grange
authors.affiliation: CHU Reims, Hôpital Robert Debré, Structure Interne d'Hépato-Gastro-Entérologie et Cancérologie Digestive, Avenue du Génénal Kœnig, Reims, F-51092, France. jvolet@chu-reims.fr.|CHU Reims, Hôpital Robert Debré, Unité de Médecine Ambulatoire Cancérologie Hématologie, Avenue du Génénal Kœnig, Reims, F-51092, France. jvolet@chu-reims.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Volet
authors.affiliation: CHU Reims, Hôpital Robert Debré, Structure Interne d'Hépato-Gastro-Entérologie et Cancérologie Digestive, Avenue du Génénal Kœnig, Reims, F-51092, France. obouche@chu-reims.fr.|CHU Reims, Hôpital Robert Debré, Unité de Médecine Ambulatoire Cancérologie Hématologie, Avenue du Génénal Kœnig, Reims, F-51092, France. obouche@chu-reims.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Bouché
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006509:Hepatitis B / Q000175:diagnosis / Q000453:epidemiology*; D006526:Hepatitis C / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000821:virology; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D011795:Surveys and Questionnaires; D055815:Young Adult