title: One-Day Use of Preoperative Topical Nonsteroidal Anti-Inflammatory Drug Prevents Intraoperative Prostaglandin Level Elevation During Femtosecond Laser-Assisted Cataract Surgery.
abstract: To determine if pretreatment with topical nonsteroidal anti-inflammatory drug (NSAID) prior to femtosecond laser-assisted cataract surgery (FLACS) prevents intraoperative prostaglandin level elevation as a potential risk factor of postoperative complications.
  
  
  
  Thirty-six patients with clinically significant cataract and without any concomitant general or ophthalmic disease were enrolled into the three age-matched groups of the study. The mean age of the patients was 62.3 ± 13.1 years. The first group of patients underwent traditional phacoemulsification (Control group), on the second group of patients FLACS was performed, and the third group of patients received topical 0.1% nepafenac pretreatment for 1one day prior to FLACS. Before the phacoemulsification part of the cataract surgery, approximately 110 µL of aqueous humor was collected in all groups. Total prostaglandin concentrations of the collected aqueous humor samples were evaluated by enzyme immunoassay (EIA).
  
  
  
  The mean of the total prostaglandin concentrations of the aqueous humor samples was 208.8 ± 140.5 pg/mL in patients in the control group, 1449.1 ± 1019.7 pg/mL in the FLACS group (p > 0.001), and 92.2 ± 51.7 pg/mL in the group pretreated with topical NSAID before the FLACS (p > 0.001 compared to FLACS; p > 0.01 compared to control), respectively.
  
  
  
  FLACS surgery increases intracameral prostaglandin concentration. However, using preoperative 1-day-long nonsteroid anti-inflammatory drops prior to FLACS, this intraoperative increase diminishes. Our study raises the possibility that NSAID pretreatment may be routinely administered before FLACS cataract surgeries to achieve a further decrease in the potential complications of increased total prostaglandin concentration during FLACS surgeries.
authors.affiliation: a Department of Ophthalmology , Semmelweis University , Budapest H-1085 , Hungary.
authors.forename: Huba J
authors.initials: HJ
authors.lastname: Kiss
authors.affiliation: a Department of Ophthalmology , Semmelweis University , Budapest H-1085 , Hungary.
authors.forename: Agnes I
authors.initials: AI
authors.lastname: Takacs
authors.affiliation: a Department of Ophthalmology , Semmelweis University , Budapest H-1085 , Hungary.
authors.forename: Kinga
authors.initials: K
authors.lastname: Kranitz
authors.affiliation: a Department of Ophthalmology , Semmelweis University , Budapest H-1085 , Hungary.
authors.forename: Gabor L
authors.initials: GL
authors.lastname: Sandor
authors.affiliation: a Department of Ophthalmology , Semmelweis University , Budapest H-1085 , Hungary.
authors.forename: Gabor
authors.initials: G
authors.lastname: Toth
authors.affiliation: b Department of Medical Chemistry , Semmelweis University , Budapest H-1094 , Hungary.
authors.forename: Beatrix
authors.initials: B
authors.lastname: Gilanyi
authors.affiliation: a Department of Ophthalmology , Semmelweis University , Budapest H-1085 , Hungary.
authors.forename: Zoltan Z
authors.initials: ZZ
authors.lastname: Nagy
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001082:Aqueous Humor / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007432:Intraoperative Period; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D018918:Phacoemulsification / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control; D011300:Preoperative Care / Q000379:methods*; D011453:Prostaglandins / Q000378:metabolism*; D013997:Time Factors; D014792:Visual Acuity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers; D009883:Ophthalmic Solutions; D011453:Prostaglandins
keywords: Cataract; NSAID; femtosecond laser; nepafenac; prostaglandin