title: Meta-analysis of the TNF-α-308G/A polymorphism and vitiligo risk.
abstract: Several case-control studies have been conducted to investigate the association between the tumor necrosis factor-α (TNF-α)-308G/A polymorphism and vitiligo risk. However, the results of these studies are inconsistent; therefore, we attempted to comprehensively evaluate the association between TNF-α-308G/A polymorphism and vitiligo risk via a meta-analysis. Studies reporting the association between TNF-α-308G/A polymorphism and vitiligo risk were retrieved from PubMed and EmBase databases. Data were extracted from these studies and the pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association. Six case-control studies including 1391 vitiligo cases and 2455 control subjects were included in this meta-analysis. The overall results showed the lack of a significant difference in TNF-α-308G/A genotype distribution between the patients and controls when the G allele and GG, GG + GA, GG, and GG genotypes were compared against the A allele and the GA + AA, AA, AA, and GA genotypes, respectively (ORs = 0.65, 0.53, 0.63, 0.41, 0.55; 95%CI = 0.35-1.23, 0.24-1.18, 0.10-4.09, 0.08-1.97, 0.25-1.21; P = 0.188, 0.121, 0.627, 0.264, 0.135, respectively). This meta-analysis suggests that the TNF-α-308G/A polymorphism may not be associated with vitiligo risk. As few studies are available in this field and current evidence remains limited, these results must be corroborated with well-designed and larger studies in the future.
authors.affiliation: Department of Dermatology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China.|Department of Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi Central Hospital.
authors.forename: G
authors.initials: G
authors.lastname: Nie
authors.affiliation: Department of Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi Central Hospital.
authors.forename: J H
authors.initials: JH
authors.lastname: Qi
authors.affiliation: Department of Dermatology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China.
authors.forename: C W
authors.initials: CW
authors.lastname: Huang
authors.affiliation: Department of Dermatology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China.
authors.forename: T
authors.initials: T
authors.lastname: Yang
authors.affiliation: Department of Dermatology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China.
authors.forename: N
authors.initials: N
authors.lastname: Shi
authors.affiliation: Department of Dermatology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Chen
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D014820:Vitiligo / Q000453:epidemiology / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha