title: Antidiabetic activity of ethanolic extract of Cyperus rotundus rhizomes in streptozotocin-induced diabetic mice.
abstract: OBJECTIVE
  In the present investigation, ethanolic extract of Cyperus rotundus (EECR) rhizomes was evaluated for antidiabetic activity in streptozotocin (STZ)-induced diabetic swiss mice.
  
  
  METHODS
  After administration of EECR extract for 3 weeks, the body weight, blood glucose, biomarker enzymes (serum glutamic pyruvic transaminase [SGPT] and serum glutamic oxaloacetic transaminase [SGOT]), and plasma lipid levels were measured in STZ-induced diabetic mice.
  
  
  RESULTS
  The ethanolic extract at dose levels of 250 and 500 mg/kg body weight revealed significant antidiabetic activity, improvement in body weight, and reduction in elevated biochemical parameters such as SGPT, SGOT, cholesterol, and triglyceride levels.
  
  
  CONCLUSIONS
  These experimental findings seemed to indicate the use of this plant in traditional Indian medicine for the treatment of diabetes.
authors.affiliation: Department of Pharmacognosy, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Singh
authors.affiliation: Department of Pharmaceutical Sciences, Bharat Institute of Technology, Meerut, Uttar Pradesh, India.
authors.forename: Ratan L
authors.initials: RL
authors.lastname: Khosa
authors.affiliation: Department of Pharmacognosy, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
authors.forename: Garima
authors.initials: G
authors.lastname: Mishra
authors.affiliation: Department of Pharmacognosy, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
authors.forename: Keshri K
authors.initials: KK
authors.lastname: Jha
keywords: Antidiabetic activity; Cyperus rotundus; phytochemical analysis; rhizome; streptozotocin