title: Microtubule Organization in the Axon: TRIM46 Determines the Orientation.
abstract: The microtubule cytoskeleton is a major determinant in neuronal polarity. In this issue of Neuron, van Beuningen et al. (2015) now report that TRIM46 forms parallel microtubule bundles in the proximal axon and reveal that it is crucial for the establishment and maintenance of neuronal polarity.
authors.affiliation: Laboratory for Axon Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE), Ludwig-Erhard-Allee 2, 53175 Bonn, Germany. Electronic address: michele.curcio@dzne.de.
authors.forename: Michele
authors.initials: M
authors.lastname: Curcio
authors.affiliation: Laboratory for Axon Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE), Ludwig-Erhard-Allee 2, 53175 Bonn, Germany. Electronic address: frank.bradke@dzne.de.
authors.forename: Frank
authors.initials: F
authors.lastname: Bradke
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure*; D016764:Cell Polarity / Q000502:physiology*; D005260:Female; D006801:Humans; D008870:Microtubules / Q000502:physiology* / Q000648:ultrastructure*; D009419:Nerve Tissue Proteins / Q000502:physiology* / Q000648:ultrastructure*; D011247:Pregnancy
chemical_list: D009419:Nerve Tissue Proteins