title: Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives.
abstract: Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3-2-carbamothioylhydrazonolup-20(29)-en-28-oic acid.
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania. ionut.ledeti@umft.ro.
authors.forename: Ionuţ
authors.initials: I
authors.lastname: Ledeţi
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania. stefana.avram@umft.ro.
authors.forename: Ştefana
authors.initials: Ş
authors.lastname: Avram
authors.affiliation: Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University Timişoara, 6 Carol Telbisz, 300001 Timisoara, Romania. vbercean@gmail.com.
authors.forename: Vasile
authors.initials: V
authors.lastname: Bercean
authors.affiliation: Research Centre for Thermal Analysis in Environmental Problems, West University of Timişoara, 300115 Timisoara, Romania. gabriela.vlase@e-uvt.ro.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Vlase
authors.affiliation: Research Centre for Thermal Analysis in Environmental Problems, West University of Timişoara, 300115 Timisoara, Romania. titus.vlase@e-uvt.ro.
authors.forename: Titus
authors.initials: T
authors.lastname: Vlase
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania. afulias@umft.ro.
authors.forename: Adriana
authors.initials: A
authors.lastname: Ledeţi
authors.affiliation: Department of Pharmacodynamics and Biopharmacy, University of Szeged, 6 Eotvos Str., H-6720 Szeged, Hungary. zupko@pharm.u-szeged.hu.
authors.forename: Istvan
authors.initials: I
authors.lastname: Zupko
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania. marius.mioc@umft.ro.
authors.forename: Marius
authors.initials: M
authors.lastname: Mioc
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania. suta.lenuta@umft.ro.
authors.forename: Lenuţa-Maria
authors.initials: LM
authors.lastname: Şuta
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania. codrutasoica@umft.ro.
authors.forename: Codruţa
authors.initials: C
authors.lastname: Şoica
authors.affiliation: Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania. cadehelean@umft.ro.
authors.forename: Cristina
authors.initials: C
authors.lastname: Dehelean
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D000094062:Betulinic Acid
chemical_list: D000970:Antineoplastic Agents; D009828:Oleanolic Acid; C118308:betulonic acid; D000094062:Betulinic Acid
keywords: MTT assay; betulonic acid derivatives; biological activity; synthesis; thermal analysis; triterpene