title: Sonic Hedgehog Signalling Pathway and Ameloblastoma - A Review.
abstract: Ameloblastoma is a benign but aggressive odontogenic neoplasm arising from odontogenic epithelium. Many theories have been proposed to explain the pathogenesis of ameloblatoma. Numerous signalling pathways have been implicated to be associated in the development and progression of this neoplasm. Studies have found association of various signalling molecules of Sonic Hedgehog Pathway, namely SHH, PTCH1, SMO, Gli 1, Gli 2, Gli 3, with ameloblastoma. Knowledge about this pathway will help us to understand the nature and behaviour of this neoplasm. This will open the door towards new treatment modalities.
authors.affiliation: Postgraduate Trainee, Department of Oral and Maxillofacial Pathology, Kalinga Institute of Dental sciences, KIIT , Bhubaneswar, Odisha, India .
authors.forename: Pallavi
authors.initials: P
authors.lastname: Mishra
authors.affiliation: Reader, Department of Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, KIIT , Bhubaneswar, Odisha. India .
authors.forename: Abikshyeet
authors.initials: A
authors.lastname: Panda
authors.affiliation: Professor and Head of the Department, Department of Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, KIIT , Bhubaneswar. Odisha. India .
authors.forename: Alokenath
authors.initials: A
authors.lastname: Bandyopadhyay
authors.affiliation: Professor, Department of Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, KIIT , Bhubaneswar, Odisha, India .
authors.forename: Harish
authors.initials: H
authors.lastname: Kumar
authors.affiliation: Reader, Department of Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, KIIT , Bhubaneswar, Odisha, India .
authors.forename: Gouse
authors.initials: G
authors.lastname: Mohiddin
keywords: Apoptosis; Gli; Odontogenic tumor; PTCH1; SMO