title: Primary cutaneous CD30+ anaplastic large cell lymphoma treated with radiotherapy and methotrexate with development of xanthomas at the sites of prior disease.
abstract: Primary cutaneous anaplastic large cell lymphoma is a rare type of cutaneous T-cell lymphoma, and the involvement of the ocular adnexa is extremely rare. Secondary xanthoma-like changes after radiation therapy or chemotherapy have been rarely reported in association with large-cell T-cell anaplastic lymphoma. We report one case of a primary C-anaplastic large cell lymphoma affecting the eyelid with fast progression with multiple nodules in various anatomic sites and development of xanthoma-like lesions after treatment.
authors.affiliation: Department of Dermatology, Ramón y Cajal University Hospital, Madrid, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: Turrión-Merino
authors.affiliation: Department of Dermatology, Ramón y Cajal University Hospital, Madrid, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Perez-Gala
authors.affiliation: Department of Dermatology, Ramón y Cajal University Hospital, Madrid, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Hermosa-Zarza
authors.affiliation: Department of Dermatology, Ramón y Cajal University Hospital, Madrid, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Urech-García-de-la-Vega
authors.affiliation: Department of Pathology, Ramón y Cajal University Hospital, Madrid, Spain.
authors.forename: Rosario
authors.initials: R
authors.lastname: Carrillo-Guijón
authors.affiliation: Department of Dermatology, Ramón y Cajal University Hospital, Madrid, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Jaén-Olasolo
mesh_terms: D005142:Eyelid Neoplasms / Q000473:pathology / Q000628:therapy; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects; D014973:Xanthomatosis / Q000209:etiology / Q000473:pathology
chemical_list: D008727:Methotrexate
keywords: anaplastic large cell lymphoma; methotrexate; ocular adnexa; radiotherapy; xanthoma