title: Role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome.
abstract: We aimed to explore the role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome (PI-IBS). Fifty NIH mice were divided into five groups (n = 10). The visceral sensitivities of PI-2W and PI-8W groups significantly exceeded than those of normal control groups (P < 0.05), which was significantly decreased in PI-B group (P < 0.05). Significantly more IL-18 and IL-1β were expressed in PI-2W and PI-8W groups than those in normal control groups (P < 0.05), which was significantly decreased in PI-B group (P < 0.05). Bifidobacterium longum may down-regulate IL-18 and IL-1β expressions by inhibiting NLRP3 inflammasome and thus reduce the visceral hypersensitivity of PI-IBS.
authors.affiliation: a Department of Gastroenterology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an , Shaanxi Province , P.R. China.|b Department of Gastroenterology , The Affiliated Hospital of Yan'an University , Yan'an , Shaanxi Province , P.R. China.
authors.forename: Qiao-Yan
authors.initials: QY
authors.lastname: Gu
authors.affiliation: a Department of Gastroenterology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an , Shaanxi Province , P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: b Department of Gastroenterology , The Affiliated Hospital of Yan'an University , Yan'an , Shaanxi Province , P.R. China.
authors.forename: Yi-Chao
authors.initials: YC
authors.lastname: Feng
mesh_terms: D000818:Animals; D000069978:Bifidobacterium longum / Q000276:immunology*; D058847:Inflammasomes / Q000276:immunology*; D036341:Intercellular Signaling Peptides and Proteins / Q000276:immunology; D053583:Interleukin-1beta / Q000276:immunology; D043183:Irritable Bowel Syndrome / Q000276:immunology*; D051379:Mice; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein / Q000276:immunology*
chemical_list: C587672:IL1B protein, mouse; D058847:Inflammasomes; D036341:Intercellular Signaling Peptides and Proteins; D053583:Interleukin-1beta; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C492716:Nlrp3 protein, mouse; C118370:interleukin-18 binding protein
keywords: Bifidobacterium longum; NLRP3; inflammasome; postinfectious irritable bowel syndrome