title: Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer.
authors.affiliation: Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC.
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Ganson
authors.affiliation: Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Povsic
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, NC.
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Sullenger
authors.affiliation: Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC.
authors.forename: John H
authors.initials: JH
authors.lastname: Alexander
authors.affiliation: Regado Biosciences, Basking Ridge, NJ.
authors.forename: Steven L
authors.initials: SL
authors.lastname: Zelenkofske
authors.affiliation: Sailstad & Associates, Durham, NC.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Sailstad
authors.affiliation: Regado Biosciences, Durham, NC.
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Rusconi
authors.affiliation: Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC; Department of Biochemistry, Duke University Medical Center, Durham, NC. Electronic address: michael.hershfield@dm.duke.edu.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Hershfield
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects* / Q000276:immunology; D052157:Aptamers, Nucleotide / Q000009:adverse effects* / Q000276:immunology; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D011092:Polyethylene Glycols
chemical_list: D000925:Anticoagulants; D052157:Aptamers, Nucleotide; D007074:Immunoglobulin G; C515724:RB 006; D011092:Polyethylene Glycols