title: Carcinosarcoma of the larynx consisting of squamous cell carcinoma and inflammatory myofibroblastic tumor components.
abstract: OBJECTIVE
  Carcinosarcoma is a rare malignant tumor with both carcinomatous and sarcomatous components. Carcinosarcoma can appear in various organs, but its occurrence in the head and neck, particularly larynx, is extremely rare. Furthermore, its response to treatment has not been well established.
  
  
  METHODS
  We report the case of a 79-year-old man with a 6-month history of hoarseness who presented with a mass having a polypoid appearance at the anterior commissure of the larynx. Further analyses revealed carcinosarcoma in the larynx that consisted of squamous cell carcinoma and an inflammatory myofibroblastic tumor (IMT).
  
  
  RESULTS
  The tumor was excised at the first hospital visited. Because pathological examination revealed an IMT and positive margin, the patient was referred to our hospital. A front lateral vertical partial laryngectomy was performed for further treatment. Histological examination demonstrated a biphasic component, consisting of squamous cell carcinoma (SCC) and IMT.
  
  
  CONCLUSIONS
  IMT rarely occurs in the head and neck region. Moreover, to best of our knowledge, no carcinosarcoma cases consisting of SCC and IMT in the larynx have been reported in the literature. The prognosis of carcinosarcoma is considered to be dependent on the type of malignant mesenchyme, and surgical excision with wide margins is generally used to treat IMT. Therefore, the treatment of laryngeal carcinosarcoma consisting of IMT can be best accomplished with complete excision of the tumor.
authors.affiliation: Department of Otorhinolaryngology & Head and Neck Surgery, Akita University Graduate School of Medicine, Akita 010-8543, Japan. Electronic address: suzukis@med.akita-u.ac.jp.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Department of Otorhinolaryngology, Noshiro Kousei Medical Center, Noshiro 016-0014, Japan.
authors.forename: Kyoshi
authors.initials: K
authors.lastname: Hanata
authors.affiliation: Department of Otorhinolaryngology & Head and Neck Surgery, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Toyoma
authors.affiliation: Division of Surgical Pathology, Akita University Hospital, Akita 010-8543, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nanjo
authors.affiliation: Department of Otorhinolaryngology & Head and Neck Surgery, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Saito
authors.affiliation: Department of Otorhinolaryngology & Head and Neck Surgery, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
authors.forename: Nobuko
authors.initials: N
authors.lastname: Iikawa
authors.affiliation: Department of Otorhinolaryngology & Head and Neck Surgery, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ishikawa
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D002296:Carcinosarcoma / Q000473:pathology* / Q000601:surgery; D006104:Granuloma, Plasma Cell / Q000473:pathology* / Q000601:surgery; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D000077195:Squamous Cell Carcinoma of Head and Neck
keywords: Carcinosarcoma; Front lateral vertical partial laryngectomy; Inflammatory myofibroblastic tumor; Laryngeal cancer; Laryngeal tumor; Partial laryngectomy; Squamous cell carcinoma