title: Assessment of the Renal Function in Potential Donors of Living Kidney Transplants: Expanded Study.
abstract: BACKGROUND
  It is very important to determine as accurately as possible the renal function in potential living renal transplant donors, especially those with limited renal function (CrCl <90 mL/m/1.73 m(2)), age older than 50 years, and cardiovascular risk factors that might favor the development of long-term kidney diseases.
  
  
  OBJECTIVE
  The objective of this study was to compare the direct measurement of glomerular filtration rate (GFR) using EDTA-Cr51 and the estimations based on creatinine (eGFR): Cr clearance (CCr) with 24-hour urine and estimated using Cockroft-Gault (adjusted by using body surface area-Mosteller formula-SC), MDRD-4, MDRD-6, and CKD-EPI to determine the usefulness of different methods from EDTA-Cr51to evaluate the kidney function.
  
  
  METHODS
  The kidney function evaluation has been made to 105 potential kidney donors using the EDTA-Cr51 method. The GFR obtained through the EDTA-Cr51 is compared with the CCr values in 24-hour urine and eGFR based on creatinine (Cockcroft-Gault, MDRD4, MDRD6, and CKD-EPI).
  
  
  RESULTS
  Using the Bland Altman graphic we have observed that the most dispersed results are obtained with the eGFR using CCr in 24-hour urine and CKD-EPI. By means of Pasing & Bablock, we realized that MDRD-4 and MDRD-6 show the highest approximation to the reference method proposed to be substituted, whereas CCr shows a high dispersion.
  
  
  CONCLUSIONS
  eGFR using MDRD-4 and MDRD-6 formulas reveal the best adjustment to the measure by EDTA-Cr51. This might represent the best option if a direct eGFR measure is not available.
authors.affiliation: UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain. Electronic address: lobama85@hotmail.com.
authors.forename: L B
authors.initials: LB
authors.lastname: Macías
authors.affiliation: UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain.
authors.forename: M S
authors.initials: MS
authors.lastname: Poblet
authors.affiliation: UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain.
authors.forename: N N
authors.initials: NN
authors.lastname: Pérez
authors.affiliation: y Medicina Nuclear, Hospital Virgen del Rocío, Sevilla, Spain.
authors.forename: R I
authors.initials: RI
authors.lastname: Jerez
authors.affiliation: UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain.
authors.forename: F M
authors.initials: FM
authors.lastname: Gonzalez Roncero
authors.affiliation: UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain.
authors.forename: G B
authors.initials: GB
authors.lastname: Blanco
authors.affiliation: UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain.
authors.forename: M A P
authors.initials: MA
authors.lastname: Valdivia
authors.affiliation: UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain.
authors.forename: A S
authors.initials: AS
authors.lastname: Benjumea
authors.affiliation: UGC-Nefrourológica, Hospital Virgen del Rocío, Sevilla, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Gentil Govantes
mesh_terms: D003404:Creatinine / Q000652:urine*; D046148:Donor Selection; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis* / Q000503:physiopathology / Q000652:urine; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests
chemical_list: D003404:Creatinine