title: Dengue Virus (DENV) Neutralizing Antibody Kinetics in Children After Symptomatic Primary and Postprimary DENV Infection.
abstract: The immune response to dengue virus (DENV) infection is complex and not fully understood. Using longitudinal data from 181 children with dengue in Thailand who were followed for up to 3 years, we describe neutralizing antibody kinetics following symptomatic DENV infection. We observed that antibody titers varied by serotype, homotypic vs heterotypic responses, and primary versus postprimary infections. The rates of change in antibody titers over time varied between primary and postprimary responses. For primary infections, titers increased from convalescence to 6 months. By comparing homotypic and heterotypic antibody titers, we saw an increase in type specificity from convalescence to 6 months for primary DENV3 infections but not primary DENV1 infections. In postprimary cases, there was a decrease in titers from convalescence up until 6 months after infection. Beginning 1 year after both primary and postprimary infections, there was evidence of increasing antibody titers, with greater increases in children with lower titers, suggesting that antibody titers were boosted due to infection and that higher levels of neutralizing antibody may be more likely to confer a sterilizing immune response. These findings may help to model virus transmission dynamics and provide baseline data to support the development of vaccines and therapeutics.
authors.affiliation: Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland.
authors.forename: Hannah E
authors.initials: HE
authors.lastname: Clapham
authors.affiliation: Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland.
authors.forename: Isabel
authors.initials: I
authors.lastname: Rodriguez-Barraquer
authors.affiliation: Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Azman
authors.affiliation: Institute for Disease Modeling, Bellevue, Washington Santa Fe Institute, Las Cruces, New Mexico New Mexico State University, Las Cruces, New Mexico.
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Althouse
authors.affiliation: Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland.
authors.forename: Henrik
authors.initials: H
authors.lastname: Salje
authors.affiliation: US Army Institute of Surgical Research, San Antonio, Texas.
authors.forename: Robert V
authors.initials: RV
authors.lastname: Gibbons
authors.affiliation: University of Rhode Island, Providence.
authors.forename: Alan L
authors.initials: AL
authors.lastname: Rothman
authors.affiliation: Department of Virology, Armed Forces Research Institute of Medical Science.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Jarman
authors.affiliation: Department of Virology, Armed Forces Research Institute of Medical Science.
authors.forename: Ananda
authors.initials: A
authors.lastname: Nisalak
authors.affiliation: Department of Virology, Armed Forces Research Institute of Medical Science.
authors.forename: Butsaya
authors.initials: B
authors.lastname: Thaisomboonsuk
authors.affiliation: Queen Sirikit National Institute of Child Health, Bangkok, Thailand.
authors.forename: Siripen
authors.initials: S
authors.lastname: Kalayanarooj
authors.affiliation: Queen Sirikit National Institute of Child Health, Bangkok, Thailand.
authors.forename: Suchitra
authors.initials: S
authors.lastname: Nimmannitya
authors.affiliation: Department of Virology, Armed Forces Research Institute of Medical Science.
authors.forename: David W
authors.initials: DW
authors.lastname: Vaughn
authors.affiliation: Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester.
authors.forename: Sharone
authors.initials: S
authors.lastname: Green
authors.affiliation: Dengue Vaccine Initiative, International Vaccine Institute, Seoul, Korea.
authors.forename: In-Kyu
authors.initials: IK
authors.lastname: Yoon
authors.affiliation: Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland Department of Biology, University of Florida, Gainesville Emerging Pathogens Institute, University of Florida, Gainesville.
authors.forename: Derek A T
authors.initials: DA
authors.lastname: Cummings
mesh_terms: D057134:Antibodies, Neutralizing / Q000097:blood / Q000276:immunology*; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000453:epidemiology / Q000276:immunology*; D003716:Dengue Virus / Q000276:immunology*; D006801:Humans; D007700:Kinetics; D008137:Longitudinal Studies; D013785:Thailand / Q000453:epidemiology
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral
keywords: dengue; longitudinal antibody kinetics; neutralizing antibody; vaccine