title: A retrospective analysis on the management of pigmented lesions using a picosecond 755-nm alexandrite laser in Asians.
abstract: OBJECTIVE
  Photo-aging in Chinese often presents with benign pigmentary lesions. Q-switched lasers for pigmentary lesions in Asians had reported a risk of post-inflammatory hyperpigmentation (PIH) up to 25%. Longer pulse widths in the millisecond domains were advocated with reduced risk of PIH. Recently, picosecond lasers of various wavelengths were introduced with proven efficacy in tattoo removal. The objective of this study is to assess the efficacy and safety of a novel picosecond 755-nm alexandrite laser for the treatment of benign pigmented lesions in Asians retrospectively.
  
  
  METHODS
  A list of all patients who received picosecond 755-nm alexandrite laser treatment at a private dermatology center in Hong Kong was included. Those who had any other laser or topical treatment during the period of picosecond laser treatment were excluded. The age, skin phototype, type of pigmentary lesion, number of treatments performed was recorded. The baseline and most recent standardized photographs were assessed by trained physicians for comparison. A score of 0-4, representing poor 0-24%, fair 25-49%, good 50-74%, excellent 75-95%, and complete 95%+ improvement was given. Adverse events associated with the laser treatment were also recorded. All patients were followed up until 6 months after the last laser session.
  
  
  RESULTS
  A total of 13 subjects were included in the present study. The number of treatment sessions received ranged from one to seven. The benign pigmentary lesions consist of Nevus of Ota, café-au-lait patches, lentigines, Becker's nevus, Hori's macules, and nevus spilus. Among patients with Nevus of Ota, one patient achieved complete clearance after four treatments and two other patients had excellent clearance after three and four sessions, respectively. Patients with café-au-lait had fair to good clearance after one to seven treatment sessions. One patient who has Hori's macules was resistant to laser treatments and a fair response was achieved after eight treatments. In the present series, two patients (4.8%) developed transient hypopigmentation, which had improved upon subsequent follow-up in both cases and none had post-inflammatory hyperpigmentation.
  
  
  CONCLUSIONS
  The novel picosecond 755-nm alexandrine laser is effective for the treatment of benign pigmentary lesions in Chinese, especially for the clearance of Nevus of Ota. Picosecond laser appears to be associated with a much lower risk of PIH for treatment of pigmentary lesions in Asians.
authors.affiliation: Division of Dermatology, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China.
authors.forename: Johnny Chun-yin
authors.initials: JC
authors.lastname: Chan
authors.affiliation: Division of Dermatology, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China.
authors.forename: Samantha Yee-nam
authors.initials: SY
authors.lastname: Shek
authors.affiliation: Department of Plastic Surgery, Tokai University, Kanagawa, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Kono
authors.affiliation: Division of Dermatology, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China.
authors.forename: Chi Keung
authors.initials: CK
authors.lastname: Yeung
authors.affiliation: Division of Dermatology, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China.|Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Henry Hin-lee
authors.initials: HH
authors.lastname: Chan
mesh_terms: D044466:Asian People; D001608:Beryllium; D005148:Facial Dermatoses / Q000601:surgery*; D005153:Facial Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000601:surgery*; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D009506:Nevus / Q000601:surgery*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000601:surgery*; D055815:Young Adult
chemical_list: C112654:alexandrite; D001608:Beryllium
keywords: Alexandrite laser; Asian; Nevus of Ota; picosecond laser; pigment; skin pigmentation