title: How to Improve the Survival of Transplanted Mesenchymal Stem Cell in Ischemic Heart?
abstract: Mesenchymal stem cell (MSC) is an intensely studied stem cell type applied for cardiac repair. For decades, the preclinical researches on animal model and clinical trials have suggested that MSC transplantation exerts therapeutic effect on ischemic heart disease. However, there remain major limitations to be overcome, one of which is the very low survival rate after transplantation in heart tissue. Various strategies have been tried to improve the MSC survival, and many of them showed promising results. In this review, we analyzed the studies in recent years to summarize the methods, effects, and mechanisms of the new strategies to address this question.
authors.affiliation: Department of Cardiology, Daping Hospital, Third Military Medical University, 10 Changjiangzhilu Road, Chongqing 400042, China.
authors.forename: Liangpeng
authors.initials: L
authors.lastname: Li
authors.affiliation: Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA 14190, USA.
authors.forename: Xiongwen
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Daping Hospital, Third Military Medical University, 10 Changjiangzhilu Road, Chongqing 400042, China.
authors.forename: Wei Eric
authors.initials: WE
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Daping Hospital, Third Military Medical University, 10 Changjiangzhilu Road, Chongqing 400042, China.
authors.forename: Chunyu
authors.initials: C
authors.lastname: Zeng