title: Polyhydroxytriterpenoids and Phenolic Constituents from Forsythia suspensa (Thunb.) Vahl Leaves.
abstract: Forsythia suspensa (Thunb.) Vahl leaves have been consumed in China as a health-promoting functional tea for centuries. Three new polyhydroxytriterpenoid glycosides named suspensanosides A-C (1-3), seven known polyhydroxytriterpenoids (4-10), and 12 known phenolics (11-22) were identified from F. suspensa leaves. Compounds 1-10, 15-17, and 22 have not been found in the Forsythia genus previously, whereas compound 14 was first reported to be isolated from the leaves of F. suspensa. All isolates were tested for their antiproliferative activities on BGC-823 and MCF-7 human tumor cell lines, whereas all phenolics were further investigated for their antioxidant activities by a DPPH assay. The results clearly demonstrate that triterpenoids, especially ursane-type triterpenoids, and the diverse phenolic components are crucial for the beneficial effects of F. suspensa leaves.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ge
authors.affiliation: Medical Examination Center, Hebei General Hospital , Shijiazhuang 050051, China.
authors.forename: Yazhen
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Hebei University of Chinese Medicine , Shijiazhuang 050200, China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Chen
authors.forename: Yufang
authors.initials: Y
authors.lastname: Wang
authors.forename: Congcong
authors.initials: C
authors.lastname: Hou
authors.forename: Yibing
authors.initials: Y
authors.lastname: Wu
authors.forename: Manli
authors.initials: M
authors.lastname: Zhang
authors.forename: Ligeng
authors.initials: L
authors.lastname: Li
authors.forename: Changhong
authors.initials: C
authors.lastname: Huo
authors.forename: Qingwen
authors.initials: Q
authors.lastname: Shi
authors.forename: Haixia
authors.initials: H
authors.lastname: Gao
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D031657:Forsythia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; D010636:Phenols; D013729:Terpenes
keywords: Forsythia suspensa (Thunb.) Vahl; antioxidant activity; antiproliferative activity; leaves; phenolics; triterpenoids