title: In Vitro Release Kinetics and Transferrin Saturation Study of Intravenous Iron Sucrose Entrapped in Poly(ethylene glycol)-Assisted Silica Xerogel.
abstract: The presence of labile iron fractions in intravenous iron supplements compromises their safety. Poly(ethylene glycol) (PEG)-assisted silica xerogel was evaluated as a potential drug carrier for iron sucrose with the purpose of limiting labile iron available for in vitro uptake by transferrin. The drug entrapped xerogels were synthesized by the sol-gel process with varying amounts of PEG. In vitro release studies were conducted in simulated body fluid (SBF) at 37 ± 0.02 °C (pH 7.4). The results indicated that the cumulative release percentage increased with the increase in the amount of PEG in the matrix. The biphasic release profile followed first-order kinetics for the first 6 h and Higuchi model for the remaining time (up to 168 h). The sample showing highest percentage of cumulative release (the xerogel with 16 % PEG) was used for in vitro transferrin saturation studies in contrast with the plain drug. The xerogel formulation exhibited 7.25 ± 0.4 % transferrin saturation in 180 min as compared to 12.89 ± 0.2 % for the raw drug. These results indicate that encapsulation of iron sucrose in PEG-assisted silica xerogel and subsequent sustained release from the matrix can improve the safety of the drug when presence of labile iron is a major concern.
authors.affiliation: School of Materials Science and Nanotechnology, Jadavpur University, Kolkata, 700032, India. jahnavijha90@gmail.com.|, 3, Lake Gardens, Kolkata, 700045, West Bengal, India. jahnavijha90@gmail.com.
authors.forename: Jahnavi
authors.initials: J
authors.lastname: Jha
authors.affiliation: School of Materials Science and Nanotechnology, Jadavpur University, Kolkata, 700032, India.
authors.forename: Suparna
authors.initials: S
authors.lastname: Chakraborty
authors.affiliation: School of Materials Science and Nanotechnology, Jadavpur University, Kolkata, 700032, India.
authors.forename: Mahua Ghosh
authors.initials: MG
authors.lastname: Chaudhuri
authors.affiliation: Department of Metallurgical and Material Engineering, Jadavpur University, Kolkata, 700032, India.
authors.forename: Rajib
authors.initials: R
authors.lastname: Dey
mesh_terms: D004337:Drug Carriers; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005290:Ferric Compounds / Q000737:chemistry / Q000494:pharmacology; D000077605:Ferric Oxide, Saccharated; D005782:Gels / Q000737:chemistry / Q000494:pharmacology*; D005937:Glucaric Acid / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology; D012822:Silicon Dioxide / Q000737:chemistry / Q000494:pharmacology; D014168:Transferrin / Q000187:drug effects / Q000378:metabolism*
chemical_list: D004337:Drug Carriers; D005290:Ferric Compounds; D005782:Gels; D014168:Transferrin; D011092:Polyethylene Glycols; D012822:Silicon Dioxide; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid
keywords: Drug delivery; Iron sucrose; PEG-assisted silica xerogel; Release kinetics; Transferrin saturation