title: Biomechanical analysis of a salt-modified polyvinyl alcohol hydrogel for knee meniscus applications, including comparison with human donor samples.
abstract: The primary objective of this research was the biomechanical analysis of a salt-modified polyvinyl alcohol hydrogel, in order to assess its potential for use as an artificial meniscal implant. Aqueous polyvinyl alcohol (PVA) was treated with a sodium sulphate (Na2SO4) solution to precipitate out the polyvinyl alcohol resulting in a pliable hydrogel. The freeze-thaw process, a strictly physical method of crosslinking, was employed to crosslink the hydrogel. Development of a meniscal shaped mould and sample housing unit allowed the production of meniscal shaped hydrogels for direct comparison to human meniscal tissue. Results obtained show that compressive responses were slightly higher in PVA/Na2SO4 menisci, displaying maximum compressive loads of 2472N, 2482N and 2476N for samples having undergone 1, 3 and 5 freeze-thaw cycles respectively. When compared to the human meniscal tissue tested under the same conditions, an average maximum load of 2467.5N was observed. This suggests that the PVA/Na2SO4 menisci are mechanically comparable to the human meniscus. Biocompatibility analysis of PVA/Na2SO4 hydrogels revealed no acute cytotoxicity. The work described herein has innovative potential in load bearing applications, specifically as an alternative to meniscectomy as replacement of critically damaged meniscal tissue in the knee joint where repair is not viable.
authors.affiliation: Centre for Industrial Services and Design, Athlone Institute of Technology, Co. Westmeath, Ireland.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Hayes
authors.affiliation: Centre for Industrial Services and Design, Athlone Institute of Technology, Co. Westmeath, Ireland.
authors.forename: Colin
authors.initials: C
authors.lastname: Curley
authors.affiliation: School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
authors.forename: Paul
authors.initials: P
authors.lastname: Tierney
authors.affiliation: Centre for Industrial Services and Design, Athlone Institute of Technology, Co. Westmeath, Ireland. Electronic address: jkennedy@ait.ie.
authors.forename: James E
authors.initials: JE
authors.lastname: Kennedy
mesh_terms: D001696:Biomechanical Phenomena; D002102:Cadaver; D002460:Cell Line; D019245:Compressive Strength; D006801:Humans; D007717:Knee; D008422:Materials Testing; D000072600:Meniscus / Q000166:cytology*; D011142:Polyvinyl Alcohol / Q000737:chemistry* / Q000633:toxicity; D013431:Sulfates / Q000737:chemistry*
chemical_list: D013431:Sulfates; C062364:polyvinyl alcohol hydrogel; C012036:sodium sulfate; D011142:Polyvinyl Alcohol
keywords: Biocompatibility; Biomechanical analysis; Cytotoxicological analysis; Hydrogel; Knee meniscus; Polyvinyl alcohol