title: Dosing antiretroviral medication when crossing time zones: a review.
abstract: International tourism continues to increase worldwide, and people living with HIV and their clinicians are increasingly confronted with the problem of how to dose antiretroviral therapy during transmeridian air travel across time zones. No guidance on this topic currently exists. This review is a response to requests from patient groups for clear, practical and evidence-based guidance for travelling on antiretroviral therapy; we present currently available data on the pharmacokinetic forgiveness and toxicity of various antiretroviral regimens, and synthesize this data to provide guidelines on how to safely dose antiretrovirals when travelling across time zones.
authors.affiliation: aTropical and Infectious Diseases Unit, Royal Liverpool University Hospital bWellcome Trust Liverpool Glasgow Centre for Global Health Research, University of Liverpool, Liverpool, UK cEuropean AIDS Treatment Group, Brussels, Belgium dDepartment of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool eSt Stephen's Centre, Chelsea & Westminster Foundation Trust, London, UK.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Lewis
authors.forename: Alain
authors.initials: A
authors.lastname: Volny-Anne
authors.forename: Catriona
authors.initials: C
authors.lastname: Waitt
authors.forename: Marta
authors.initials: M
authors.lastname: Boffito
authors.forename: Saye
authors.initials: S
authors.lastname: Khoo
mesh_terms: D044966:Anti-Retroviral Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D014195:Travel
chemical_list: D044966:Anti-Retroviral Agents