title: 3D Micropillars Guide the Mechanobiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
abstract: 3D micropillars generated by photolithography are used as a platform to probe by atomic force microscopy the mechanodynamics of human induced pluripotent stem cell-derived cardiomyocytes. 3D micropillars guide subcellular cytoskeletal modifications of cardiomyocytes and lead to biochemical changes altering beating rate, stiffness, and calcium dynamics of the cells.
authors.affiliation: ZIK HIKE - Centre for Innovation Competence (Humoral Immune Reactions in Cardiovascular Diseases), Ernst-Moritz-Arndt-University, 17489, Greifswald, Germany.
authors.forename: Raghavendra
authors.initials: R
authors.lastname: Palankar
authors.affiliation: ZIK HIKE - Centre for Innovation Competence (Humoral Immune Reactions in Cardiovascular Diseases), Ernst-Moritz-Arndt-University, 17489, Greifswald, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Glaubitz
authors.affiliation: Institute for Physics, University of Greifswald, 17489, Greifswald, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Martens
authors.affiliation: ZIK HIKE - Centre for Innovation Competence (Humoral Immune Reactions in Cardiovascular Diseases), Ernst-Moritz-Arndt-University, 17489, Greifswald, Germany.
authors.forename: Nikolay
authors.initials: N
authors.lastname: Medvedev
authors.affiliation: Institute for Physics, University of Greifswald, 17489, Greifswald, Germany.
authors.forename: Marvin
authors.initials: M
authors.lastname: von der Ehe
authors.affiliation: Clinic for Internal Medicine B (Cardiology), University of Greifswald Sauebruchstrasse, 17475, Greifswald, Germany.|DZHK (German Centre for Cardiovascular Research) partner site, Greifswald, Germany.
authors.forename: Stephan B
authors.initials: SB
authors.lastname: Felix
authors.affiliation: Institute for Physics, University of Greifswald, 17489, Greifswald, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Münzenberg
authors.affiliation: ZIK HIKE - Centre for Innovation Competence (Humoral Immune Reactions in Cardiovascular Diseases), Ernst-Moritz-Arndt-University, 17489, Greifswald, Germany.|DZHK (German Centre for Cardiovascular Research) partner site, Greifswald, Germany.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Delcea
mesh_terms: D002118:Calcium / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism / Q000502:physiology*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000502:physiology*
chemical_list: D002118:Calcium
keywords: 3D micropillars; atomic force microscopy; induced pluripotent stem cells; mechanobiology; sarcomeres