title: The activities of serum paraoxonase and arylesterase and lipid profile in acute myeloid leukemia: preliminary results.
abstract: OBJECTIVE
  To investigate the activities of serum paraoxonase-1 (PON1) and arylesterase (ARE), and the lipid profile in newly diagnosed acute myeloid leukemia (AML) patients.
  
  
  METHODS
  Thirty-two persons (16 of AML and 16 of healthy control) were included to the study. PON1 and ARE activities were measured as spectrophotometrically in serum samples. High density lipoprotein (HDL), low density lipoprotein (LDL), total cholesterol (TC), triglyceride (TG) were analyzed in autoanalyzer.
  
  
  RESULTS
  PON1 activities were respectively 16.04 U/L and 18.6 U/L in AML and healthy controls. There was no statistical significance between groups (p > 0.05). The mean ARE activities were respectively 0.21 U/L and 0.36 U/L in AML and healthy controls. Serum ARE activity significantly decreased in AML group (p < 0.001). Serum HDL values were significantly decreased (181.8 ± 76.2 mg/dl; p = 0.002) in AML. There was no difference in total cholesterol, LDL and triglyceride values (respectively; 181.8 ± 76.2 mg/dl, 120.6 ± 64.6 mg/dl, 157.3 ± 87.2 mg/dl; p > 0.05) between AML and controls.
  
  
  CONCLUSIONS
  This is the first documented study about serum PON1 activity in AML patients. Although serum PON1 activities were not changed in both groups, our data suggest that the decreased serum ARE activity and HDL levels may be related the pathogenesis of AML.
authors.affiliation: 1Giresun University, Faculty of Health Sciences, Piraziz/Giresun, Turkey. egemen.akgun@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Çebi
authors.forename: E
authors.initials: E
authors.lastname: Akgun
authors.forename: R
authors.initials: R
authors.lastname: Esen
authors.forename: H
authors.initials: H
authors.lastname: Demir
authors.forename: A
authors.initials: A
authors.lastname: Çifci
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase