title: Interleukin-13 as an important cytokine: A review on its roles in some human diseases.
abstract: Interleukin-13 (IL-13) as a pleiotropic cytokine acts through the IL-13Ra1/IL-4Ra complex to induce activation responses which contribute to the inflammatory diseases. Genetic polymorphisms in IL-13 and its receptor components have been proved to be associated with higher disease prevalence rates. Animal models such as in IL-13 deficient mice and transgenic animals also have been confirmed the critical role of this cytokine in the immune responses, mostly by IL-13 neutralization and IL-13/IL-4 dual neutralization strategies. This review highlights IL-13 structure as well as its pivotal roles in the normal physiologic and pathologic states. It is followed by a section on the recent findings on IL-13 receptors and signalling mechanisms to briefly summarize its functions in the immune systems. IL-13 roles in the human diseases such as asthma, systematic sclerosis, and some inflammatory diseases are described concisely. Finally some of the ongoing therapeutic applications are presented to comprehensively review IL-13 mediator roles.
authors.affiliation: Immunology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|Immunology Department, Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Narges
authors.initials: N
authors.lastname: Seyfizadeh
authors.affiliation: Umbilical Cord Stem Cell Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|Department of Clinical Biochemistry and Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Nayer
authors.initials: N
authors.lastname: Seyfizadeh
authors.affiliation: Immunology Department, Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Tohid
authors.initials: T
authors.lastname: Gharibi
authors.affiliation: Immunology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Babaloo
mesh_terms: D000818:Animals; D004194:Disease / Q000235:genetics; D006801:Humans; D007107:Immune System / Q000276:immunology; D007109:Immunity; D018793:Interleukin-13 / Q000737:chemistry / Q000235:genetics / Q000276:immunology*
chemical_list: D018793:Interleukin-13
keywords: Interleukin-13; anti-tumour immunity; asthma; gastrointestinal inflammatory diseases; systemic sclerosis