title: Natural products in the discovery of novel sonosensitizers.
abstract: Sonodynamic therapy (SDT), which involves a combination of low-intensity ultrasound and chemotherapeutic agents called sonosensitizers, has been developed for its promising, distinct advantages, such as its noninvasive nature relative to traditional surgery and radiotherapy, greater accessibility to treat deeply located diseases than photodynamic therapy, and low systemic toxicity. Sonosensitizers derived from natural products play an important role in SDT, exerting potent sonodynamic activity for the treatment of various diseases including cancer, infections, and inflammation. In this review, the mechanism of SDT is systematically discussed and the recent advancements in the discovery and development of novel natural sonosensitizers for SDT are summarized. Furthermore, potential limitations and future perspectives are also presented.
authors.affiliation: School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
authors.forename: Xin
authors.initials: X
authors.lastname: Pang
authors.affiliation: School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong. Electronic address: csxu@cuhk.edu.hk.
authors.forename: Chuanshan
authors.initials: C
authors.lastname: Xu
authors.affiliation: School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
authors.forename: Yue
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
authors.forename: Qicai
authors.initials: Q
authors.lastname: Xiao
authors.affiliation: School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong. Electronic address: awnleung@cuhk.edu.hk.
authors.forename: Albert Wingnang
authors.initials: AW
authors.lastname: Leung
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001688:Biological Products / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D014464:Ultrasonic Therapy
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products
keywords: Cancer; Natural products; Sonodynamic therapy; Sonosensitizers; Ultrasound