title: TP53 codon 72 polymorphic variants (Rs1042522) frequency in the Ukrainian population.
abstract: OBJECTIVE
  To estimate frequencies of polymorphic variants of TP53 codon 72 in the Ukrainian population.
  
  
  METHODS
  We determined the allele frequencies for 148 healthy people. Genotyping was performed by allele specific polymerase chain reaction.
  
  
  RESULTS
  We identified 31 individuals (20.9 %) with Arg/Arg genotype, Arg/Pro genotype was identified for 116 indi viduals (78.4 %), whereas genotype Pro/Pro was rare and was found in one person only (0.7 %). Genotype distribu tions were not within Hardy Weinberg equilibrium (χ2 = 59,7, p < 0.0001).
  
  
  CONCLUSIONS
  Arg and Pro allele frequencies in the population of Ukraine are 60 and 40 % respectively, which is sig nificantly differ from the frequencies described in the literature for Poland, the Czech Republic, the USA and Brazil.
authors.affiliation: Taras Shevchenko National University of Kyiv, Educational and Scientific Centre Institute of Biology, Volodymyrska str., 64, Kyiv, 01601, Ukraine.
authors.forename: Y M
authors.initials: YM
authors.lastname: Mishchuk
authors.affiliation: Taras Shevchenko National University of Kyiv, Educational and Scientific Centre Institute of Biology, Volodymyrska str., 64, Kyiv, 01601, Ukraine.
authors.forename: S V
authors.initials: SV
authors.lastname: Serga
authors.affiliation: State Institution D. F. Chebotarev Institute of Gerontology NAMS Ukraine, Vyshhorodska str., 67, Kyiv, 04114, Ukraine.
authors.forename: O K
authors.initials: OK
authors.lastname: Koliada
authors.affiliation: Taras Shevchenko National University of Kyiv, Educational and Scientific Centre Institute of Biology, Volodymyrska str., 64, Kyiv, 01601, Ukraine.
authors.forename: L I
authors.initials: LI
authors.lastname: Ostapchenko
authors.affiliation: Taras Shevchenko National University of Kyiv, Educational and Scientific Centre Institute of Biology, Volodymyrska str., 64, Kyiv, 01601, Ukraine.
authors.forename: S V
authors.initials: SV
authors.lastname: Demydov
authors.affiliation: Taras Shevchenko National University of Kyiv, Educational and Scientific Centre Institute of Biology, Volodymyrska str., 64, Kyiv, 01601, Ukraine.
authors.forename: I A
authors.initials: IA
authors.lastname: Kozeretska
keywords: UV radiation; codon 72 polymorphism; gene TP53; the cancer risk