title: Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.
abstract: Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological activities potentially beneficial to human health. (+)-Aeroplysinin-1 is a secondary metabolite isolated from marine sponges with a wide spectrum of bio-activities. (+)-Aeroplysinin-1 has potent antibiotic effects on Gram-positive bacteria and several dinoflagellate microalgae causing toxic blooms. In preclinical studies, (+)-aeroplysinin-1 has been shown to have promising anti-inflammatory, anti-angiogenic and anti-tumor effects. Due to its versatility, (+)-aeroplysinin-1 might have a pharmaceutical interest for the treatment of different pathologies.
authors.affiliation: Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, and IBIMA (Biomedical Research Institute of Málaga), Universidad de Málaga, Andalucía Tech, Málaga 29071, Spain. jandrovil@hotmail.com.|CIBER de Enfermedades Raras (CIBERER), Málaga E-29071, Spain. jandrovil@hotmail.com.
authors.forename: Javier A
authors.initials: JA
authors.lastname: García-Vilas
authors.affiliation: Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, and IBIMA (Biomedical Research Institute of Málaga), Universidad de Málaga, Andalucía Tech, Málaga 29071, Spain. bmpoveda@gmail.com.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Martínez-Poveda
authors.affiliation: Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, and IBIMA (Biomedical Research Institute of Málaga), Universidad de Málaga, Andalucía Tech, Málaga 29071, Spain. quesada@uma.es.|CIBER de Enfermedades Raras (CIBERER), Málaga E-29071, Spain. quesada@uma.es.
authors.forename: Ana R
authors.initials: AR
authors.lastname: Quesada
authors.affiliation: Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, and IBIMA (Biomedical Research Institute of Málaga), Universidad de Málaga, Andalucía Tech, Málaga 29071, Spain. medina@uma.es.|CIBER de Enfermedades Raras (CIBERER), Málaga E-29071, Spain. medina@uma.es.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Medina
mesh_terms: D000097:Acetonitriles / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D053138:Cyclohexenes / Q000737:chemistry* / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D011161:Porifera; D012623:Seawater
chemical_list: D000097:Acetonitriles; D000900:Anti-Bacterial Agents; D053138:Cyclohexenes; C042151:aeroplysinin I
keywords: (+)-aeroplysinin-1; angiogenesis; cancer; inflammation; marine drugs; sponges