title: Prediction of Protein-Protein Interaction Sites Based on Naive Bayes Classifier.
abstract: Protein functions through interactions with other proteins and biomolecules and these interactions occur on the so-called interface residues of the protein sequences. Identifying interface residues makes us better understand the biological mechanism of protein interaction. Meanwhile, information about the interface residues contributes to the understanding of metabolic, signal transduction networks and indicates directions in drug designing. In recent years, researchers have focused on developing new computational methods for predicting protein interface residues. Here we creatively used a 181-dimension protein sequence feature vector as input to the Naive Bayes Classifier- (NBC-) based method to predict interaction sites in protein-protein complexes interaction. The prediction of interaction sites in protein interactions is regarded as an amino acid residue binary classification problem by applying NBC with protein sequence features. Independent test results suggested that Naive Bayes Classifier-based method with the protein sequence features as input vectors performed well.
authors.affiliation: Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Haijiang
authors.initials: H
authors.lastname: Geng
authors.affiliation: Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing 210009, China ; State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Lu
authors.affiliation: Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing 210009, China ; State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Fangrong
authors.initials: F
authors.lastname: Yan