title: Macrophage cell death upon intracellular bacterial infection.
abstract: Macrophage-pathogen interaction is a complex process and the outcome of this tag-of-war for both sides is to live or die. Without attempting to be comprehensive, this review will discuss the complexity and significance of the interaction outcomes between macrophages and some facultative intracellular bacterial pathogens as exemplified byFrancisella, Salmonella, ShigellaandYersinia. Upon bacterial infection, macrophages can die by a variety of ways, such as apoptosis, autophagic cell death, necrosis, necroptosis, oncosis, pyronecrosis, pyroptosisetc, which is the focus of this review.
authors.affiliation: Institute of Inflammation and Diseases, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China ; Institute of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Xin-He
authors.initials: XH
authors.lastname: Lai
authors.affiliation: Institute of Inflammation and Diseases, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China ; Institute of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China ; Department of Dermato-venerology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Yunsheng
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Institute of Inflammation and Diseases, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China ; Institute of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China ; Department of Pediatric Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Chen
authors.affiliation: Institute of Inflammation and Diseases, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China ; Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA).
authors.forename: Yi
authors.initials: Y
authors.lastname: Ren
keywords: apoptosis; autophagic cell death; bacterial pathogen; macrophage polarization; necroptosis; necrosis; oncosis; pyronecrosis; pyroptosis