title: Post-traumatic hypopituitarism and fatigue.
abstract: Post-traumatic hypopituitarism (PTH) associated with chronic cognitive, psychiatric, and/or behavioural sequelae is common following moderate to severe traumatic brain injury (TBI). More specifically, due to a cascade of hormonal deficiencies secondary to PTH, individuals with TBI may experience debilitating fatigue that can negatively impact functional recovery, as it can limit participation in brain injury rehabilitation services and lead to an increase in maladaptive lifestyle practices. While the mechanisms underlying fatigue and TBI are not entirely understood, the current review will address the specific anatomy and physiology of the pituitary gland, as well as the association between pituitary dysfunction and fatigue in individuals with TBI.
authors.affiliation: a The Transitional Learning Center , Galveston , TX , USA.
authors.forename: Brent E
authors.initials: BE
authors.lastname: Masel
authors.affiliation: a The Transitional Learning Center , Galveston , TX , USA.
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Zgaljardic
authors.affiliation: a The Transitional Learning Center , Galveston , TX , USA.
authors.forename: Jack
authors.initials: J
authors.lastname: Forman
mesh_terms: D000070642:Brain Injuries, Traumatic / Q000150:complications*; D005221:Fatigue / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007018:Hypopituitarism / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism
keywords: Fatigue; Hormones; Pituitary