title: Modular Vaccine Design Using Carrier-Free Capsules Assembled from Polyionic Immune Signals.
abstract: New vaccine adjuvants that direct immune cells toward specific fates could support more potent and selective options for diseases spanning infection to cancer. However, the empirical nature of vaccines and the complexity of many formulations has hindered design of well-defined and easily characterized vaccines. We hypothesized that nanostructured capsules assembled entirely from polyionic immune signals might support a platform for simple, modular vaccines. These immune-polyelectrolyte (iPEM) capsules offer a high signal density, selectively expand T cells in mice, and drive functional responses during tumor challenge. iPEMs incorporating clinically relevant antigens could improve vaccine definition and support more programmable control over immunity.
authors.affiliation: Fischell Department of Bioengineering, University of Maryland , 2212 Jeong H. Kim Building, College Park, Maryland 20742, United States.
authors.forename: Yu-Chieh
authors.initials: YC
authors.lastname: Chiu
authors.affiliation: Fischell Department of Bioengineering, University of Maryland , 2212 Jeong H. Kim Building, College Park, Maryland 20742, United States.
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Gammon
authors.affiliation: Fischell Department of Bioengineering, University of Maryland , 2212 Jeong H. Kim Building, College Park, Maryland 20742, United States.
authors.forename: James I
authors.initials: JI
authors.lastname: Andorko
authors.affiliation: Fischell Department of Bioengineering, University of Maryland , 2212 Jeong H. Kim Building, College Park, Maryland 20742, United States.
authors.forename: Lisa H
authors.initials: LH
authors.lastname: Tostanoski
authors.affiliation: Fischell Department of Bioengineering, University of Maryland , 2212 Jeong H. Kim Building, College Park, Maryland 20742, United States ; Department of Microbiology and Immunology, University of Maryland Medical School , 685 West Baltimore Street, HSF-I Suite 380, Baltimore, Maryland 21201, United States ; Marlene and Stewart Greenebaum Cancer Center , 22 South Greene Street, Suite N9E17, Baltimore, Maryland 21201, United States.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Jewell
keywords: immunology; polyelectrolyte multilayer; rational design; self-assembly; vaccine