title: [Onset time and efficacy of sublingual immunotherapy with Dermatophagoides farinae drops in children with allergic rhinitis].
abstract: OBJECTIVE
  To investigate the onset time and efficacy of sublingual immunotherapy (SLIT) with Dermatophagoides farinae drops in children with house dust mites (HDM)-induced allergic rhinitis (AR).
  
  
  METHODS
  One hundred and forty three children with perennial moderate to severe HDM-induced AR were treated by SLIT with standardized Dermatophagoides farinae extract. One hundred children who finally completed two years treatment were divided into two groups according to the age: younger children group (aged 4-8 years, n = 52) and older children group (aged 9-14 years, n = 48). Respectively, Each children was assessed before and after 1st, 2nd, 3rd, 6th, 12th, 24th months of the treatment. Total nasal symptom score (TNSS), total medication score (TMS) and visual analogue scale (VAS) were evaluated at each visit. All clinical data were analyzed retrospectively with the SPSS 19.0 software.
  
  
  RESULTS
  TNSS, TMS and VAS of two groups decreased significantly after three months of the treatment compared with before (younger children group: Z value was -3.843, -3.534, -3.940, older children group: Z value was -3.938, -3.405, -3.953, all P < 0.05). TNSS and VAS of younger children group decreased significantly after two months of the treatment compared with before (6.4 ± 1.6, 5.3 ± 1.4 vs 8.6 ± 1.2, 7.9 ± 1.6, Z value was -3.843, -3.940, both P < 0.05). Five children (5%) experienced local adverse events and 2 children (2%) experienced mild systemic adverse events. No severe adverse events happened during the treatment.
  
  
  CONCLUSIONS
  SLIT with Dermatophagoides farinae drops is an efficient and safe treatment for children with HDM-induced AR. Its onset of action can be observed as early as 3 months after treatment.
authors.affiliation: Department of Otorhinolaryngology, Hangzhou Traditional Chinese Medicine Hospital, Hangzhou 310007, China; Email: 15957169678@163.com.
authors.forename: Zhiling
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Otorhinolaryngology, Hangzhou Traditional Chinese Medicine Hospital, Hangzhou 310007, China.
authors.forename: Yasheng
authors.initials: Y
authors.lastname: Qian
authors.affiliation: Department of Otorhinolaryngology, Hangzhou Traditional Chinese Medicine Hospital, Hangzhou 310007, China.
authors.forename: Suqin
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Otorhinolaryngology, Hangzhou Traditional Chinese Medicine Hospital, Hangzhou 310007, China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Otorhinolaryngology, Hangzhou Traditional Chinese Medicine Hospital, Hangzhou 310007, China.
authors.forename: Shiying
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Otorhinolaryngology, Hangzhou Traditional Chinese Medicine Hospital, Hangzhou 310007, China.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Yin
authors.affiliation: Department of Otorhinolaryngology, Hangzhou Traditional Chinese Medicine Hospital, Hangzhou 310007, China.
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Otorhinolaryngology, Hangzhou Traditional Chinese Medicine Hospital, Hangzhou 310007, China.
authors.forename: Huawei
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Otorhinolaryngology, Hangzhou Traditional Chinese Medicine Hospital, Hangzhou 310007, China.
authors.forename: Gan
authors.initials: G
authors.lastname: Wang
mesh_terms: D000286:Administration, Sublingual; D000293:Adolescent; D000485:Allergens / Q000008:administration & dosage*; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D040001:Dermatophagoides farinae; D006801:Humans; D012189:Retrospective Studies; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D012984:Software; D063729:Sublingual Immunotherapy; D016896:Treatment Outcome
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides