title: Infusional 5-Fluorouracil, Leucovorin and Docetaxel in Advanced Gastric Cancer.
abstract: OBJECTIVE
  This study was performed to estimate the response rate and toxicity of a combination chemotherapy, which included infusional 5-Fluorouracil, Leucovorin and Docetaxel in the treatment of patients with an advanced gastric carcinoma.
  
  
  METHODS
  Twenty two advanced gastric cancer patients, with a bidimensionally measurable or an evaluable disease, were enrolled in this study. The patients received a 5-fluorouracil 1, 000 mg/m2 intravenous (IV) 24 hour infusion (Day 1~3), leucovorin 20 mg/m2 (Day 1~3) and docetaxel 75 mg/m2 intravenously (Day 2) every 3 weeks.
  
  
  RESULTS
  The overall response rate was 45.0%. The median duration of response was 10.0 weeks (range: 4~24), the median time to response was 8 weeks (range: 8~20) the median time to progression was 30.0 weeks (95% CI: 16.3~43.2) and the median overall survival duration was 36.0 weeks (95% CI: 1.7~70.2). The median cumulative dose of 5-fluorouracil were 316.2 mg/m2/week and docetaxel was 23.9 mg/m2/week. WHO grade III, IV neutropenia, thromocytopenia and anemia occurred in 50.0%, 4.5% and 4.5% of patients, respectively. There were no occurrence of WHO grade III and IV nausea, vomiting, mucositis, conspitation, diarrhea, or neurotoxicity.
  
  
  CONCLUSIONS
  This chemotherapy regimen, including infusional 5-fluorouracil, leucovorin and docetaxel was an active agent against advanced gastric cancer patients, especially for previous chemotherapy naive patients.
authors.forename: Yong Tai
authors.initials: YT
authors.lastname: Kim
authors.forename: Joo Hyuk
authors.initials: JH
authors.lastname: Sohn
authors.forename: So Hun
authors.initials: SH
authors.lastname: Kim
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Rha
authors.forename: Chul
authors.initials: C
authors.lastname: Kim
authors.forename: Jae Kyung
authors.initials: JK
authors.lastname: Roh
authors.forename: Byung Soo
authors.initials: BS
authors.lastname: Kim
authors.forename: Woo Ick
authors.initials: WI
authors.lastname: Jang
authors.forename: Hyun Cheol
authors.initials: HC
authors.lastname: Chung
keywords: Combination Chemotherapy; Docetaxel; Infusional 5-FU; Leucovorin; Stomach neoplasm