title: Eosinophils Reduce Chronic Inflammation in Adipose Tissue by Secreting Th2 Cytokines and Promoting M2 Macrophages Polarization.
abstract: Obesity is now recognized as a low-grade, chronic inflammatory disease that is linked to a myriad of disorders including cardiovascular diseases, type 2 diabetes, and liver diseases. Recently it is found that eosinophils accelerate alternative activation macrophage (AAM) polarization by secreting Th2 type cytokines such as interleukin-4 and interleukin-13, thereby reducing metainflammation in adipose tissue. In this review, we focused on the role of eosinophils in regulating metabolic homeostasis and obesity.
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yang
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Cui
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.
authors.forename: Manna
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Qian
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.
authors.forename: Chunjun
authors.initials: C
authors.lastname: Sheng
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.
authors.forename: Shen
authors.initials: S
authors.lastname: Qu
authors.affiliation: Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.
authors.forename: Le
authors.initials: L
authors.lastname: Bu