title: TLS in Tumors: What Lies Within.
abstract: The role of tertiary lymphoid structures (TLS) in cancer has recently been illustrated and revisited using mouse models. Joshi et al. describe regulatory T (Treg) cell infiltration and functional heterogeneity of TLS in lung tumors. Finkin et al. report that inflammation-associated TLS serve as niche for tumor progenitor cells, which may lead to recurrence in hepatocellular-carcinoma.
authors.affiliation: INSERM, UMR_S 1138, Cordeliers Research Center, F-75006, Paris, France; University Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Cordeliers Research Center, F-75006, Paris, France; UPMC University Paris 06, Sorbonne Universités, UMR_S 1138, Cordeliers Research Center, F-75006, Paris, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Sautès-Fridman
authors.affiliation: INSERM, UMR_S 1138, Cordeliers Research Center, F-75006, Paris, France; University Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Cordeliers Research Center, F-75006, Paris, France; UPMC University Paris 06, Sorbonne Universités, UMR_S 1138, Cordeliers Research Center, F-75006, Paris, France. Electronic address: herve.fridman@crc.jussieu.fr.
authors.forename: Wolf Herman
authors.initials: WH
authors.lastname: Fridman
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006528:Carcinoma, Hepatocellular / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007157:Immunologic Surveillance; D008175:Lung Neoplasms / Q000276:immunology*; D051379:Mice; D014411:Neoplastic Stem Cells / Q000502:physiology*; D055153:Stem Cell Niche; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D000072717:Tertiary Lymphoid Structures / Q000276:immunology*