title: Evaluation of response after neoadjuvant treatment in soft tissue sarcomas; the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG) recommendations for pathological examination and reporting.
abstract: At present, there is not a commonly used and generally accepted standardized approach for the pathologic evaluation of pretreated soft tissue sarcomas. Also, it is still unclear whether the cut-off for prognostic relevance is similar in the many different histological subtypes of STS. This manuscript, produced by a European Organization for Research and Treatment of Cancer - Soft Tissue and Bone Sarcoma Group (EORTC-STBSG) endorsed task force, aims to propose standardization of the pathological examination process and the reporting of STS resection specimens after neoadjuvant radio- and/or chemotherapy.
authors.affiliation: Gerhard-Domagk-Institute of Pathology of the University Hospital, Münster, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Wardelmann
authors.affiliation: Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address: r.haas@nki.nl.
authors.forename: R L
authors.initials: RL
authors.lastname: Haas
authors.affiliation: Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: J V M G
authors.initials: JV
authors.lastname: Bovée
authors.affiliation: Department of Medical Biology and Pathology of Gustave Roussy, Villejuif, France.
authors.forename: Ph
authors.initials: P
authors.lastname: Terrier
authors.affiliation: Department of Pathology, University of Texas MD Anderson Cancer Center, Houston TX, USA.
authors.forename: A
authors.initials: A
authors.lastname: Lazar
authors.affiliation: Department of Radiology, The Royal Marsden Hospital, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Messiou
authors.affiliation: Department of Radiotherapy, Institut Gustave Roussy, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: LePechoux
authors.affiliation: Gerhard-Domagk-Institute of Pathology of the University Hospital, Münster, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Hartmann
authors.affiliation: Department of Pathology, Centre Georges-Francois Leclerc, Dijon, France.
authors.forename: F
authors.initials: F
authors.lastname: Collin
authors.affiliation: Sarcoma Unit, The Royal Marsden Hospital, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Fisher
authors.affiliation: Institute of Pathology, University of Heidelberg, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Mechtersheimer
authors.affiliation: Department of Oncology and of Anatomic Pathology, General Hospital of Treviso, Italy.
authors.forename: A P
authors.initials: AP
authors.lastname: DeiTos
authors.affiliation: Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Stacchiotti
authors.affiliation: Department of Medical Oncology, The Royal Marsden Hospital, London, UK.
authors.forename: R L
authors.initials: RL
authors.lastname: Jones
authors.affiliation: Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Gronchi
authors.affiliation: Department of Surgery, Institute Curie, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Bonvalot
mesh_terms: D001859:Bone Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008853:Microscopy / Q000379:methods; D020360:Neoadjuvant Therapy / Q000379:methods; D012509:Sarcoma / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy
keywords: Chemotherapy; Guideline; Pathology; Radiotherapy; Response evaluation; Soft tissue sarcoma