title: Serum Gamma-Glutamyltransferase Levels are Associated With Concomitant Cardiovascular Risk Factors in Korean Hypertensive Patients: A Nationwide Population-Based Study.
abstract: Previous studies suggested that serum gamma-glutamyltransferase (GGT) levels were associated with the prevalence of cardiovascular disease (CVD) risk factors including hypertension, diabetes mellitus (DM), and metabolic syndrome (MetS) in the general population. We aimed to investigate the relationship between serum GGT levels and CVD risk factors in Korean hypertensive patients. This cross-sectional study was based on data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2011 to 2012. The analysis included 1541 hypertensive participants. Study participants were divided into groups according to tertiles of serum GGT with cutoff points of 20 and 35 U/L. Serum GGT levels were positively associated with the components of MetS (P value < 0.05, except for systolic blood pressure and high-density lipoprotein cholesterol). After adjusting for possible confounders, serum GGT levels were associated with an increased risk of MetS, high waist circumference, high triglyceride level, fasting plasma glucose, DM, and the urinary albumin-to-creatinine ratio (P = 0.001). In hypertensive patients, serum GGT levels are positively associated with major cardiovascular risk factors such as MetS, DM, and urinary albumin excretion.
authors.affiliation: From the Department of Family Medicine, Korea University, College of Medicine, Seoul (SL, DHK, HYN, Y-JY, G-EN, J-SC, J-EL, J-ES); Department of Family Medicine, Hallym University, College of Medicine, Chunchon (Y-KR); Department of Family Medicine, Catholic University, College of Medicine (S-YJ); Department of Biostatistics, Catholic University, College of Medicine, Seoul, Republic of Korea (KDH, Y-GP).
authors.forename: Sangsu
authors.initials: S
authors.lastname: Lee
authors.forename: Do Hoon
authors.initials: DH
authors.lastname: Kim
authors.forename: Hyo Yun
authors.initials: HY
authors.lastname: Nam
authors.forename: Yong-Kyun
authors.initials: YK
authors.lastname: Roh
authors.forename: Sang-Yhun
authors.initials: SY
authors.lastname: Ju
authors.forename: Yeo-Joon
authors.initials: YJ
authors.lastname: Yoon
authors.forename: Ga-Eun
authors.initials: GE
authors.lastname: Nam
authors.forename: Jun-Seok
authors.initials: JS
authors.lastname: Choi
authors.forename: Jong-Eun
authors.initials: JE
authors.lastname: Lee
authors.forename: Jung-Eun
authors.initials: JE
authors.lastname: Sang
authors.forename: Kyungdo
authors.initials: K
authors.lastname: Han
authors.forename: Yong-Gyu
authors.initials: YG
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose; D001794:Blood Pressure; D015992:Body Mass Index; D001837:Body Weights and Measures; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology; D050171:Dyslipidemias / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology; D008875:Middle Aged; D009749:Nutrition Surveys; D056910:Republic of Korea; D012307:Risk Factors; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D001786:Blood Glucose; D003404:Creatinine; D005723:gamma-Glutamyltransferase