title: The microbiome and childhood diseases: Focus on brain-gut axis.
abstract: Many childhood diseases such as autism spectrum disorders, allergic disease, and obesity are on the increase. Although environmental factors are thought to play a role in this increase. The mechanisms at play are unclear but increasing evidence points to an interaction with the gastrointestinal microbiota as being potentially important. Recently this community of bacteria and perturbation of its colonization in early life has been linked to a number of diseases. Many factors are capable of influencing this colonization and ultimately leading to an altered gut microbiota which is known to affect key systems within the body. The impact of the microbial composition of our gastrointestinal tract on systems outside the gut is also becoming apparent. Here we highlight the factors that are capable of impacting on microbiota colonization in early-life and the developing systems that are affected and finally how this may be involved in the manifestation of childhood diseases.
authors.affiliation: Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.|Laboratory of Neurogastroenterology, APC Microbiome Institute, Cork, Ireland.
authors.forename: Siobhain M
authors.initials: SM
authors.lastname: O' Mahony
authors.affiliation: Laboratory of Neurogastroenterology, APC Microbiome Institute, Cork, Ireland.
authors.forename: Roman M
authors.initials: RM
authors.lastname: Stilling
authors.affiliation: Laboratory of Neurogastroenterology, APC Microbiome Institute, Cork, Ireland.|Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland.
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Dinan
authors.affiliation: Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.|Laboratory of Neurogastroenterology, APC Microbiome Institute, Cork, Ireland.
authors.forename: John F
authors.initials: JF
authors.lastname: Cryan
mesh_terms: D001927:Brain Diseases / Q000382:microbiology*; D002648:Child; D005767:Gastrointestinal Diseases / Q000382:microbiology*; D006801:Humans; D064307:Microbiota / Q000502:physiology*
keywords: child development; microbiome