title: Assessing Heavy Metal and PCB Exposure from Tap Water by Measuring Levels in Plasma from Sporadic Breast Cancer Patients, a Pilot Study.
abstract: Breast cancer (BrCA) is the most common cancer affecting women around the world. However, it does not arise from the same causative agent among all women. Genetic markers have been associated with heritable or familial breast cancers, which may or may not be confounded by environmental factors, whereas sporadic breast cancer cases are more likely attributable to environmental exposures. Approximately 85% of women diagnosed with BrCA have no family history of the disease. Given this overwhelming bias, more plausible etiologic mechanisms should be investigated to accurately assess a woman's risk of acquiring breast cancer. It is known that breast cancer risk is highly influenced by exogenous environmental cues altering cancer genes either by genotoxic mechanisms (DNA mutations) or otherwise. Risk assessment should comprehensively incorporate exposures to exogenous factors that are linked to a woman's individual susceptibility. However, the exact role that some environmental agents (EA) play in tumor formation and/or cancer gene regulation is unclear. In this pilot project, we begin a multi-disciplinary approach to investigate the intersection of environmental exposures, cancer gene response, and BrCA risk. Here, we present data that show environmental exposure to heavy metals and PCBs in drinking water, heavy metal presence in plasma of nine patients with sporadic BrCA, and Toxic Release Inventory and geological data for a metal of concern, uranium, in Northeast Georgia.
authors.affiliation: Department of Environmental Health Sciences, University of Georgia, Athens, GA 30602, USA. zimeri@uga.edu.
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Zimeri
authors.affiliation: Department of Epidemiology &amp; Biostatistics, University of Georgia, Athens, GA 30602, USA. swagner@uga.edu.
authors.forename: Sara Wagner
authors.initials: SW
authors.lastname: Robb
authors.affiliation: Laboratory for Environmental Analysis, University of Georgia, Athens, GA 30602, USA. shassan@uga.edu.
authors.forename: Sayed M
authors.initials: SM
authors.lastname: Hassan
authors.affiliation: Department of Genetics, Medical Partnership, University of Georgia, Athens, GA 30602, USA; Davidson Life Sciences Building, 120 East Green St., Athens, GA 30602, USA. rupahire@uga.edu.
authors.forename: Rupali R
authors.initials: RR
authors.lastname: Hire
authors.affiliation: Department of Genetics, Medical Partnership, University of Georgia, Athens, GA 30602, USA; Davidson Life Sciences Building, 120 East Green St., Athens, GA 30602, USA. mbdavis@uga.edu.
authors.forename: Melissa B
authors.initials: MB
authors.lastname: Davis
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics*; D060766:Drinking Water / Q000009:adverse effects* / Q000737:chemistry*; D005260:Female; D005786:Gene Expression Regulation; D019398:Genes, BRCA1 / Q000187:drug effects*; D005845:Georgia; D006801:Humans; D019216:Metals, Heavy / Q000097:blood / Q000633:toxicity*; D008875:Middle Aged; D010865:Pilot Projects; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000633:toxicity*; D018570:Risk Assessment
chemical_list: D060766:Drinking Water; D019216:Metals, Heavy; D011078:Polychlorinated Biphenyls
keywords: PCBs; heavy metals; sporadic breast cancer; uranium