title: In quest of optimal drug-supported and targeted bone regeneration in the cranio facial area: a review of techniques and methods.
abstract: Craniofacial bone structures are frequently and extensively affected by trauma, tumors, bone infections and diseases, age-related degeneration and atrophy, as well as congenital malformations and developmental anomalies. Consequently, severe encumbrances are imposed on both patients and healthcare systems due to the complex and lengthy treatment duration. The search for alternative methods to bone transplantation, grafting and the use of homologous or heterologous bone thus responds to one of the most significant problems in human medicine. This review focuses on the current consensus of bone-tissue engineering in the craniofacial area with emphasis on drug-induced stem cell differentiation and induced bone regeneration.
authors.affiliation: a Department of Maxillofacial Surgery and Oral Implantology , "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania .
authors.forename: Ondine
authors.initials: O
authors.lastname: Lucaciu
authors.affiliation: a Department of Maxillofacial Surgery and Oral Implantology , "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania .
authors.forename: Bogdan
authors.initials: B
authors.lastname: Crisan
authors.affiliation: a Department of Maxillofacial Surgery and Oral Implantology , "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania .
authors.forename: Liana
authors.initials: L
authors.lastname: Crisan
authors.affiliation: a Department of Maxillofacial Surgery and Oral Implantology , "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania .
authors.forename: Mihaela
authors.initials: M
authors.lastname: Baciut
authors.affiliation: b "Ion Chiricuta" Oncological Institute , Cluj-Napoca , Romania .
authors.forename: Olga
authors.initials: O
authors.lastname: Soritau
authors.affiliation: a Department of Maxillofacial Surgery and Oral Implantology , "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania .
authors.forename: Simion
authors.initials: S
authors.lastname: Bran
authors.affiliation: c National Institute for Research and Development of Isotopic and Molecular Technologies , Cluj-Napoca , Romania .
authors.forename: Alexandru Radu
authors.initials: AR
authors.lastname: Biris
authors.affiliation: a Department of Maxillofacial Surgery and Oral Implantology , "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania .
authors.forename: Lucia
authors.initials: L
authors.lastname: Hurubeanu
authors.affiliation: a Department of Maxillofacial Surgery and Oral Implantology , "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania .
authors.forename: Mihaela
authors.initials: M
authors.lastname: Hedesiu
authors.affiliation: a Department of Maxillofacial Surgery and Oral Implantology , "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania .
authors.forename: Sergiu
authors.initials: S
authors.lastname: Vacaras
authors.affiliation: d Paracelsius Krankenhaus Ruit , Germany , and.
authors.forename: Winfried
authors.initials: W
authors.lastname: Kretschmer
authors.affiliation: e Technical University of Cluj-Napoca , Cluj-Napoca , Romania.
authors.forename: Noemi
authors.initials: N
authors.lastname: Dirzu
authors.affiliation: a Department of Maxillofacial Surgery and Oral Implantology , "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania .
authors.forename: Radu Septimiu
authors.initials: RS
authors.lastname: Campian
authors.affiliation: a Department of Maxillofacial Surgery and Oral Implantology , "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania .
authors.forename: Grigore
authors.initials: G
authors.lastname: Baciut
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D016025:Bone Transplantation / Q000379:methods; D002454:Cell Differentiation / Q000187:drug effects / Q000528:radiation effects; D016503:Drug Delivery Systems; D006801:Humans; D012886:Skull / Q000187:drug effects* / Q000473:pathology / Q000637:transplantation; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
keywords: Drug-supported bone regeneration; biomaterials; drug-enhanced stem cells differentiation; laser-therapy; scaffolds as vehicles for drug delivery; targeted drug delivery