title: In situ rapid preparation of homochiral metal-organic framework coated column for open tubular capillary electrochromatography.
abstract: Fabricating metal-organic frameworks (MOFs) with the use of nucleating agents in the microenvironment have attracted increasing attention recently. Herein, a simple and rapid synthesis method was developed to in situ fabricate homochiral MOF [Zn(s-nip)2]n in the capillary inner wall by using ZnO nanoparticles as efficient nucleating agents for open tubular capillary electrochromatography (OT-CEC) separation of monoamine neurotransmitters enantiomers of epinephrine, isoprenaline and synephrine, the diastereoisomers of ephedrine and pseudoephedrine, the isomers of nitrophenols and analogues of bisphenols with good resolution. The relative standard deviations (RSDs) for the analytes migration time of intra-day, inter-day and column-to-column were in the range of 0.8-2.1% (n=10), 0.3-3.2% (n=3) and 3.2-9.3% (n=3), respectively. Additionally, the homochiral MOF [Zn(s-nip)2]n coated capillary column could be successively used over 260 runs without observable change in the separation efficiency.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China; Department of Chemistry, Lanzhou University, Lanzhou 730000, China.
authors.forename: Congjie
authors.initials: C
authors.lastname: Pan
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China; Department of Chemistry, Lanzhou University, Lanzhou 730000, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China; Department of Chemistry, Lanzhou University, Lanzhou 730000, China; Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou 730000, China. Electronic address: chenxg@lzu.edu.cn.
authors.forename: Xingguo
authors.initials: X
authors.lastname: Chen
mesh_terms: D015306:Biogenic Monoamines / Q000032:analysis; D053801:Capillary Electrochromatography / Q000295:instrumentation* / Q000379:methods; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry; D053768:Metal Nanoparticles; D018377:Neurotransmitter Agents / Q000032:analysis; D009596:Nitrophenols / Q000032:analysis; D011422:Propionates / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D015032:Zinc; D015034:Zinc Oxide / Q000737:chemistry
chemical_list: C000609754:(S)-2-(1,8-naphthalimido)-3-(4-imidazole)propanoate; D015306:Biogenic Monoamines; D056831:Coordination Complexes; D007093:Imidazoles; D018377:Neurotransmitter Agents; D009596:Nitrophenols; D011422:Propionates; D015032:Zinc; D015034:Zinc Oxide
keywords: Homochiral metal-organic framework; In situ synthesis; Nucleating agent; Open tubular capillary electrochromatography; ZnO nanoparticles