title: Direct Synthesis of an α,ω-Diester from 2,7-Octadienol as Bulk Feedstock in Three Tandem Catalytic Steps.
abstract: A new tandem catalytic process was designed and developed as a tool for the direct conversion of the widely available feedstock 2,7-octadienol into an α,ω-diester. This innovative auto-tandem catalysis is atom efficient and consists of three consecutive palladium-catalysed reactions: ether formation, ether carbonylation and alkoxycarbonylation. By using the design of experiments (DoE) approach, significant parameters were determined and the yield of the desired α,ω-diester was optimised. Model substrates allowed deeper insight into the progress of the reaction to be gained and, as a result, the reaction sequence was uncovered. Furthermore, by simply applying other ligands, a different reaction path was followed, allowing other, new tandem catalytic sequences to be explored and enabling new compounds to be obtained.
authors.affiliation: Technische Universität Dortmund, Fakultät Bio- und Chemieingenieurwesen, Emil-Figgestr. 66, 44227, Dortmund, Germany.
authors.forename: Karoline A
authors.initials: KA
authors.lastname: Ostrowski
authors.affiliation: Technische Universität Dortmund, Fakultät Bio- und Chemieingenieurwesen, Emil-Figgestr. 66, 44227, Dortmund, Germany.
authors.forename: Dennis
authors.initials: D
authors.lastname: Vogelsang
authors.affiliation: Technische Universität Dortmund, Fakultät Bio- und Chemieingenieurwesen, Emil-Figgestr. 66, 44227, Dortmund, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Seidensticker
authors.affiliation: Technische Universität Dortmund, Fakultät Bio- und Chemieingenieurwesen, Emil-Figgestr. 66, 44227, Dortmund, Germany.
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Vorholt
keywords: carbonylation; high-pressure chemistry; homogeneous catalysis; palladium; tandem catalysis