title: New Ent-Kaurane-Type Diterpene Glycosides and Benzophenone from Ranunculus muricatus Linn.
abstract: Two new ent-kaurane diterpene glycosides, ranunculosides A (1) and B (2), and a new benzophenone, ranunculone C (3), were isolated from the aerial part of Ranunculus muricatus Linn. The chemical structures of compounds 1-3 were established to be (2S)-ent-kauran-2β-ol-15-en-14-O-β-d-glucopyranoside, (2S,4S)-ent-kauran-2β,18-diol-15-en-14-O-β-d-glucopyranoside, and (R)-3-[2-(3,4-dihydroxybenzoyl)-4,5-dihydroxy-phenyl]-2-hydroxylpropanoic acid, respectively, by spectroscopic data and chemical methods. The absolute configuration of 1 was determined by the combinational application of RP-HPLC analysis and Mosher's method.
authors.affiliation: Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy Jinan University, Guangzhou 510632, China. Biling5@163.com.
authors.forename: Bi-Ling
authors.initials: BL
authors.lastname: Wu
authors.affiliation: Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy Jinan University, Guangzhou 510632, China. zouhuiliang@163.com.
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Zou
authors.affiliation: Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy Jinan University, Guangzhou 510632, China. qinfangmin_77@126.com.
authors.forename: Fang-Min
authors.initials: FM
authors.lastname: Qin
authors.affiliation: Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy Jinan University, Guangzhou 510632, China. hongyu88926@126.com.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Li
authors.affiliation: Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy Jinan University, Guangzhou 510632, China. guangxzh@sina.com.
authors.forename: Guang-Xiong
authors.initials: GX
authors.lastname: Zhou
mesh_terms: D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D008968:Molecular Conformation; D010936:Plant Extracts; D031947:Ranunculus / Q000737:chemistry*
chemical_list: D001577:Benzophenones; D004224:Diterpenes; D006027:Glycosides; D010936:Plant Extracts; C047723:benzophenone
keywords: Ranunculus muricatus; benzophenone; ent-kaurane diterpene; ranunculone C; ranunculoside