title: Increase in cases of Guillain-Barré syndrome during a Chikungunya outbreak, French Polynesia, 2014 to 2015.
abstract: During the recent chikungunya fever outbreak in French Polynesia in October 2014 to March 2015, we observed an abnormally high number of patients with neurological deficit. Clinical presentation and complementary exams were suggestive of Guillain-Barré syndrome (GBS) for nine patients. All nine had a recent dengue-like syndrome and tested positive for chikungunya virus (CHIKV) in serology or RT-PCR. GBS incidence was increased four- to nine-fold during this period, suggesting a link to CHIKV infection.
authors.affiliation: Internal Medicine Department, French Polynesia Tertiary Hospital, Tahiti, French Polynesia.
authors.forename: Erwan
authors.initials: E
authors.lastname: Oehler
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Fournier
authors.forename: Isabelle
authors.initials: I
authors.lastname: Leparc-Goffart
authors.forename: Philippe
authors.initials: P
authors.lastname: Larre
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Cubizolle
authors.forename: Chantal
authors.initials: C
authors.lastname: Sookhareea
authors.forename: Stéphane
authors.initials: S
authors.lastname: Lastère
authors.forename: Frédéric
authors.initials: F
authors.lastname: Ghawche
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D000368:Aged; D065632:Chikungunya Fever / Q000453:epidemiology; D002646:Chikungunya virus / Q000235:genetics / Q000302:isolation & purification; D004196:Disease Outbreaks; D004576:Electromyography; D005260:Female; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007136:Immunoglobulins / Q000008:administration & dosage*; D007155:Immunologic Factors / Q000008:administration & dosage*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009443:Neuritis / Q000188:drug therapy / Q000276:immunology*; D011114:Polynesia / Q000453:epidemiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016896:Treatment Outcome
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007155:Immunologic Factors
keywords: French Polynesia; chikungunya; chikungunya virus; clinic; outbreaks; vector-borne infections; viral infections