title: A novel cream formulation containing nicotinamide 4%, arbutin 3%, bisabolol 1%, and retinaldehyde 0.05% for treatment of epidermal melasma.
abstract: Epidermal melasma is a common hyperpigmentation disorder that can be challenging to treat. Although current treatment options for melasma are limited, topical skin-lightening preparations have widely been used as alternatives to hydroquinone. In this prospective, single-arm, open-label study, treatment of epidermal melasma with a novel cream formulation containing nicotinamide 4%, arbutin 3%, bisabolol 1%, and retinaldehyde 0.05% was associated with reductions in Melasma Area and Severity Index (MASI) scores as well as total melasma surface area as measured by medical imaging software. Treatment outcomes including tolerance and safety profiles as well as patient satisfaction and product appreciation showed this novel cosmetic compound may be valuable in the treatment of epidermal melasma.
authors.affiliation: Dermatology Clinic, Santa Casa de São Paulo Hospital and Medical School, Brazil.
authors.forename: Elisete I
authors.initials: EI
authors.lastname: Crocco
authors.affiliation: Dermatology Clinic, Santa Casa de São Paulo Hospital and Medical School, Brazil.
authors.forename: John V
authors.initials: JV
authors.lastname: Veasey
authors.affiliation: Dermatology Clinic, Santa Casa de São Paulo Hospital and Medical School, Brazil.
authors.forename: Maria F
authors.initials: MF
authors.lastname: Boin
authors.affiliation: Department of Pathology, Santa Casa de São Paulo Hospital and Medical School, Brazil.
authors.forename: Rute F
authors.initials: RF
authors.lastname: Lellis
authors.affiliation: Dermatology Clinic, Santa Casa de São Paulo Hospital and Medical School, Brazil.
authors.forename: Renata O
authors.initials: RO
authors.lastname: Alves
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D001104:Arbutin / Q000008:administration & dosage; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008548:Melanosis / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D000081222:Monocyclic Sesquiterpenes; D009536:Niacinamide / Q000008:administration & dosage; D017060:Patient Satisfaction; D011446:Prospective Studies; D012172:Retinaldehyde / Q000008:administration & dosage; D012717:Sesquiterpenes / Q000008:administration & dosage; D012720:Severity of Illness Index; D063465:Skin Cream; D012984:Software; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes; C004497:bisabolol; D009536:Niacinamide; D001104:Arbutin; D012172:Retinaldehyde