title: Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses.
abstract: Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray structural analysis of GII.17 P domains from 2002 to 2014 and 2015 suggested that surface-exposed substitutions on the uppermost part of the P domain might have generated a novel 2014-2015 GII.17 variant.
authors.affiliation: Schaller Research Group, University of Heidelberg and DKFZ, Heidelberg, Germany Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Bishal Kumar
authors.initials: BK
authors.lastname: Singh
authors.affiliation: Schaller Research Group, University of Heidelberg and DKFZ, Heidelberg, Germany Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Koromyslova
authors.affiliation: Schaller Research Group, University of Heidelberg and DKFZ, Heidelberg, Germany Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Lisa
authors.initials: L
authors.lastname: Hefele
authors.affiliation: Schaller Research Group, University of Heidelberg and DKFZ, Heidelberg, Germany Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Clara
authors.initials: C
authors.lastname: Gürth
authors.affiliation: Schaller Research Group, University of Heidelberg and DKFZ, Heidelberg, Germany Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany g.hansman@dkfz.de.
authors.forename: Grant S
authors.initials: GS
authors.lastname: Hansman
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000914:Antibodies, Viral / Q000276:immunology; D017250:Caliciviridae Infections / Q000821:virology*; D002213:Capsid / Q000737:chemistry* / Q000276:immunology; D003429:Cross Reactions; D018360:Crystallography, X-Ray; D019143:Evolution, Molecular; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D029322:Norovirus / Q000737:chemistry / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D011487:Protein Conformation
chemical_list: D000914:Antibodies, Viral