title: Magnetically triggered nanovehicles for controlled drug release as a colorectal cancer therapy.
abstract: Magnetic silica core/shell nanovehicles presenting atherosclerotic plaque-specific peptide-1 (AP-1) as a targeting ligand (MPVA-AP1 nanovehicles) have been prepared through a double-emulsion method and surface modification. Amphiphilic poly(vinyl alcohol) was introduced as a polymer binder to encapsulate various drug molecules (hydrophobic, hydrophilic, polymeric) and magnetic iron oxide (Fe3O4) nanoparticles. Under a high-frequency magnetic field, magnetic carriers (diameter: ca. 50 nm) incorporating the anti-cancer drug doxorubicin collapsed, releasing approximately 80% of the drug payload, due to the heat generated by the rapidly rotating Fe3O4 nanoparticles, thereby realizing rapid and accurate controlled drug release. Simultaneously, the magnetic Fe3O4 themselves could also kill the tumor cells through a hyperthermia effect (inductive heating). Unlike their ungrafted congeners (MPVA nanovehicles), the AP1-grafted nanovehicles bound efficiently to colorectal cancer cells (CT26-IL4Rα), thereby displaying tumor-cell selectivity. The combination of remote control, targeted dosing, drug-loading flexibility, and thermotherapy and chemotherapy suggests that magnetic nanovehicles such as MPVA-AP1 have great potential for application in cancer therapy.
authors.affiliation: Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan.
authors.forename: Chih-Yu
authors.initials: CY
authors.lastname: Kuo
authors.affiliation: Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan. Electronic address: tyliu0322@gmail.com.
authors.forename: Ting-Yu
authors.initials: TY
authors.lastname: Liu
authors.affiliation: Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan.
authors.forename: Tzu-Yi
authors.initials: TY
authors.lastname: Chan
authors.affiliation: Institute of Microbiology and Immunology, School of Life Science, Nation Yang-Ming University, Taipei 11221, Taiwan.
authors.forename: Sung-Chen
authors.initials: SC
authors.lastname: Tsai
authors.affiliation: Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
authors.forename: Andri
authors.initials: A
authors.lastname: Hardiansyah
authors.affiliation: Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Huang
authors.affiliation: Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
authors.forename: Ming-Chien
authors.initials: MC
authors.lastname: Yang
authors.affiliation: Department of Surgery, Taipei City Hospital, Zhongxing Branch, Taipei 10341, Taiwan.
authors.forename: Ruey-Hwa
authors.initials: RH
authors.lastname: Lu
authors.affiliation: Department of Surgery, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan; Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11221, Taiwan.
authors.forename: Jeng-Kai
authors.initials: JK
authors.lastname: Jiang
authors.affiliation: Department of Education and Research, Taipei City Hospital, Taipei 10629, Taiwan.
authors.forename: Chih-Yung
authors.initials: CY
authors.lastname: Yang
authors.affiliation: Institute of Microbiology and Immunology, School of Life Science, Nation Yang-Ming University, Taipei 11221, Taiwan; Department of Surgery, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
authors.forename: Chi-Hung
authors.initials: CH
authors.lastname: Lin
authors.affiliation: Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan; Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan; Department of Materials Science and Engineering, National Taiwan University, Taipei 10617, Taiwan.
authors.forename: Wen-Yen
authors.initials: WY
authors.lastname: Chiu
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D004317:Doxorubicin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry; D065546:Drug Liberation; D005290:Ferric Compounds / Q000737:chemistry; D060526:Magnetic Fields; D051379:Mice; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D013499:Surface Properties; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005290:Ferric Compounds; C000499:ferric oxide; D004317:Doxorubicin
keywords: Drug controlled release; Magnetic nanovehicles; Stimuli-triggered release; Surface modification; Targeting therapy