title: [Diagnostic value of SATB2, CK7 and CK20 in colorectal cancer].
abstract: OBJECTIVE
  To study the diagnostic value of SATB2, together with CK7 and CK20, in colorectal cancer.
  
  
  METHODS
  Immunohistochemical study for SATB2, CK7 and CK20 was carried out in 210 cases of colorectal cancer tissue, 100 cases of non-colorectal cancer tissue, 90 cases of lymph node metastases and 50 cases of normal colorectal mucosa.
  
  
  RESULTS
  The sensitivity and specificity of CK20+/CK7- immunophenotype for diagnosis of colorectal adenocarcinoma were 78.1% and 92.0%, respectively. When triple markers were used, the immunophenotype CK20+/CK7-/SATB2+ had a sensitivity of 57.1% and a specificity of 98.0%. When combining the immunophenotype of SATB2+/CK7- or CK20+/CK7-, the sensitivity was 85.7% and specificity was 90.0%.
  
  
  CONCLUSIONS
  A panel of immunohistochemical markers SATB2, CK7 and CK20 could increase the specificity for diagnosis of colorectal adenocarcinoma significantly. SATB2 is considered as a useful adjunct in this respect.
authors.affiliation: Department of Pathology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Jinghuan
authors.initials: J
authors.lastname: Lyn
authors.forename: Yanfen
authors.initials: Y
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Minghong
authors.initials: M
authors.lastname: Shen
authors.affiliation: E-mail: zhouxj3456@163.com.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D016130:Immunophenotyping; D053554:Keratin-20 / Q000378:metabolism; D053552:Keratin-7 / Q000378:metabolism*; D008207:Lymphatic Metastasis; D036961:Matrix Attachment Region Binding Proteins / Q000378:metabolism*; D012680:Sensitivity and Specificity; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C507499:KRT20 protein, human; D053554:Keratin-20; D053552:Keratin-7; D036961:Matrix Attachment Region Binding Proteins; C521297:SATB2 protein, human; D014157:Transcription Factors