title: Curcumin loaded mesoporous silica: an effective drug delivery system for cancer treatment.
abstract: In the present study, we report the delivery of anti-cancer drug curcumin to cancer cells using mesoporous silica materials. A series of mesoporous silica material based drug delivery systems (S2, S4 and S6) were first designed and developed through the amine functionalization of KIT-6, MSU-2 and MCM-41 followed by the loading of curcumin. The curcumin loaded materials were characterized with several physico-chemical techniques and thoroughly screened on cancer cells to evaluate their in vitro drug delivery efficacy. All the curcumin loaded silica materials exhibited higher cellular uptake and inhibition of cancer cell viability compared to pristine curcumin. The effective internalization of curcumin in cancer cells through the mesoporous silica materials initiated the generation of intracellular reactive oxygen species and the down regulation of poly ADP ribose polymerase (PARP) enzyme levels compared to free curcumin leading to the activation of apoptosis. This study shows that the anti-cancer activity of curcumin can be potentiated by loading onto mesoporous silica materials. Therefore, we strongly believe that mesoporous silica based curcumin loaded drug delivery systems may have future potential applications for the treatment of cancers.
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, India. crpatra@iict.res.in patra.chitta@gmail.com.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kotcherlakota
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, India. crpatra@iict.res.in patra.chitta@gmail.com and Academy of Scientific and Innovative Research (AcSIR), Training and Development Complex, CSIR Campus, CSIR Road, Taramani, Chennai - 600 113, India.
authors.forename: Ayan Kumar
authors.initials: AK
authors.lastname: Barui
authors.affiliation: Departamento de Biología y Geología, Física y Quimica Inorgánica, E.S.C.E.T., Universidad Rey Juan Carlos, Calle Tulipán s/n, 28933, Móstoles, Madrid, Spain. santiago.gomez@urjc.es.
authors.forename: Sanjiv
authors.initials: S
authors.lastname: Prashar
authors.affiliation: Departamento de Biología y Geología, Física y Quimica Inorgánica, E.S.C.E.T., Universidad Rey Juan Carlos, Calle Tulipán s/n, 28933, Móstoles, Madrid, Spain. santiago.gomez@urjc.es.
authors.forename: Mariano
authors.initials: M
authors.lastname: Fajardo
authors.affiliation: Departamento de Química Inorgánica, Universidad de Granada, Facultad de Ciencias, Fuente Nueva s/n 18071, Granada, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Briones
authors.affiliation: Departamento de Química Inorgánica, Universidad de Granada, Facultad de Ciencias, Fuente Nueva s/n 18071, Granada, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Rodríguez-Diéguez
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, India. crpatra@iict.res.in patra.chitta@gmail.com and Academy of Scientific and Innovative Research (AcSIR), Training and Development Complex, CSIR Campus, CSIR Road, Taramani, Chennai - 600 113, India.
authors.forename: Chitta Ranjan
authors.initials: CR
authors.lastname: Patra
authors.affiliation: Departamento de Biología y Geología, Física y Quimica Inorgánica, E.S.C.E.T., Universidad Rey Juan Carlos, Calle Tulipán s/n, 28933, Móstoles, Madrid, Spain. santiago.gomez@urjc.es.
authors.forename: Santiago
authors.initials: S
authors.lastname: Gómez-Ruiz
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000737:chemistry* / Q000494:pharmacology*; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry* / Q000378:metabolism; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; C509968:MCM-41; D012822:Silicon Dioxide; D011065:Poly(ADP-ribose) Polymerases; D003474:Curcumin