title: Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study.
abstract: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia.
  
  
  
  To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35).
  
  
  
  A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA).
  
  
  
  (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P < .05, Family-Wise Error [FWE] corrected). (2) Pooled-sample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task.
  
  
  
  During self-agency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic; filip.spaniel@nudz.cz.
authors.forename: Filip
authors.initials: F
authors.lastname: Spaniel
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic; MR-Unit ZRIR, IKEM, Institute for Clinical and Experimental Medicine, Prague, Czech Republic;
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Tintera
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic; MR-Unit ZRIR, IKEM, Institute for Clinical and Experimental Medicine, Prague, Czech Republic;
authors.forename: Jan
authors.initials: J
authors.lastname: Rydlo
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic; MR-Unit ZRIR, IKEM, Institute for Clinical and Experimental Medicine, Prague, Czech Republic;
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ibrahim
authors.affiliation: Department of Psychiatry, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic;
authors.forename: Tomas
authors.initials: T
authors.lastname: Kasparek
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic;
authors.forename: Jiri
authors.initials: J
authors.lastname: Horacek
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic;
authors.forename: Yuliya
authors.initials: Y
authors.lastname: Zaytseva
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic; Psychiatric Hospital Bohnice, Prague, Czech Republic;
authors.forename: Martin
authors.initials: M
authors.lastname: Matejka
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic; Psychiatric Hospital Bohnice, Prague, Czech Republic;
authors.forename: Marketa
authors.initials: M
authors.lastname: Fialova
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic; Psychiatric Hospital Bohnice, Prague, Czech Republic;
authors.forename: Andrea
authors.initials: A
authors.lastname: Slovakova
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic; Psychiatric Hospital Bohnice, Prague, Czech Republic;
authors.forename: Pavol
authors.initials: P
authors.lastname: Mikolas
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic;
authors.forename: Tomas
authors.initials: T
authors.lastname: Melicher
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic;
authors.forename: Natalie
authors.initials: N
authors.lastname: Görnerova
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic;
authors.forename: Cyril
authors.initials: C
authors.lastname: Höschl
authors.affiliation: National Institute of Mental Health, Klecany, Czech Republic; Department of Psychiatry, Dalhousie University, Halifax, Canada.
authors.forename: Tomas
authors.initials: T
authors.lastname: Hajek
mesh_terms: D000328:Adult; D063132:Connectome / Q000379:methods*; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009043:Motor Activity; D009415:Nerve Net / Q000503:physiopathology*; D010468:Perceptual Disorders / Q000209:etiology / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology*; D011597:Psychomotor Performance; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology*
keywords: fMRI; first-episode schizophrenia; independent component analysis; neuroimaging; self-agency