title: Carbon Dots with Intrinsic Theranostic Properties for Bioimaging, Red-Light-Triggered Photodynamic/Photothermal Simultaneous Therapy In Vitro and In Vivo.
abstract: Cancer nanotheranostics combining therapeutic and imaging functions within a single nanoplatform are extremely important for nanomedicine. In this study, carbon dots (C-dots) with intrinsic theranostic properties are prepared by using polythiophene benzoic acid as carbon source. The obtained C-dots absorb light in the range of 400-700 nm and emit bright fluorescence in the red region (peaking from 640 to 680 nm at different excitations). More importantly, the obtained C-dots exhibit dual photodynamic and photothermal effects under 635 nm laser irradiation with a singlet oxygen ((1)O2) generating efficiency of 27% and high photothermal conversion efficiency of 36.2%. These unique properties enable C-dots to act as a red-light-triggered theranostic agent for imaging-guided photodynamic-photothermal simultaneous therapy in vitro and in vivo within the therapeutic window (600-1000 nm).
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Jiechao
authors.initials: J
authors.lastname: Ge
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Qingyan
authors.initials: Q
authors.lastname: Jia
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Liu
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Minhuan
authors.initials: M
authors.lastname: Lan
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Bingjiang
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Guo
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Hangyue
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Laser Medicine, Chinese PLA General Hospital, Beijing, 100853, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Laser Medicine, Chinese PLA General Hospital, Beijing, 100853, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Meng
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Wang
mesh_terms: D000818:Animals; D002244:Carbon / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D007834:Lasers; D051379:Mice; D008819:Mice, Nude; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use / Q000648:ultrastructure; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D061848:Optical Imaging; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use; D010789:Phototherapy; D026082:Singlet Oxygen / Q000378:metabolism; D013696:Temperature; D000068936:Theranostic Nanomedicine; D014183:Transplantation, Heterologous
chemical_list: D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D002244:Carbon
keywords: bioimaging; carbon dots; photodynamic therapy; photothermal therapy; theranostics