title: Anti-inflammatory properties of quebecol and its derivatives.
abstract: Herein we report our results on the anti-inflammatory activity of quebecol, a polyphenolic compound discovered in maple syrup. Bioassays demonstrated that quebecol has an anti-inflammatory effect on LPS-induced NF-κB activation and inhibits the secretion of two pro-inflammatory cytokines, IL-6 and TNF-α. We also prepared and tested precursors of quebecol and its derivatives corresponding to its substructures of interest, with the aim to study the structure-activity relationships. Comparing the results obtained for all tested compounds allowed the identification of the main moiety responsible for the anti-inflammatory activity of quebecol.
authors.affiliation: Département de Chimie and PROTEO, Université Laval, 1045 avenue de la Médecine, Québec G1V 0A6, Canada.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Cardinal
authors.affiliation: Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, 2420 rue de la Terrasse, Québec G1V 0A6, Canada.
authors.forename: Jabrane
authors.initials: J
authors.lastname: Azelmat
authors.affiliation: Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, 2420 rue de la Terrasse, Québec G1V 0A6, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Grenier
authors.affiliation: Département de Chimie and PROTEO, Université Laval, 1045 avenue de la Médecine, Québec G1V 0A6, Canada. Electronic address: normand.voyer@chm.ulaval.ca.
authors.forename: Normand
authors.initials: N
authors.lastname: Voyer
mesh_terms: D031002:Acer / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D015850:Interleukin-6 / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D016328:NF-kappa B / Q000276:immunology; D059808:Polyphenols / Q000737:chemistry* / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D008070:Lipopolysaccharides; D016328:NF-kappa B; D059808:Polyphenols; D014409:Tumor Necrosis Factor-alpha
keywords: Anti-inflammatory activity; Inhibition of NF-κB activation; Inhibition of cytokine secretion; Natural polyphenol; Quebecol