title: Dynamic prediction of the need for renal replacement therapy in intensive care unit patients using a simple and robust model.
abstract: We aimed at identifying a model that dynamically predicts future need for renal replacement therapy (RRT) in intensive care unit (ICU) patients and can easily be implemented for online monitoring at the bedside. 7290 interdisciplinary ICU admissions were investigated. Patients with <3 days of stay or RRT in the first 2 days were excluded. 1624 of the remaining 2625 patients had a normal serum creatinine at admission. Every second of these 1624 patients was used for model calibration whereas the other half and, in addition, the 1001 patients with elevated serum creatinine were exclusively used for validation. Discriminant analysis was used to determine and validate a combination of clinical parameters that predicts the need for RRT 72 h ahead. Based on the calibration sample, stepwise discriminant analysis selected the serum values of (1) current urea, (2) current lactate, (3) the ratio of current and admission serum creatinine, and (4) the mean urine output of the previous 24 h. In the validation datasets, the model reached areas under the receiver operating characteristic curve of 0.866 and 0.833 in patients with normal and elevated serum creatinine at admission, respectively. Moreover, the model's predictive value extended to at least 5 days prior to initiation of RRT and exceeded that of the RIFLE classification at all investigated prediction intervals. We identified a robust model that dynamically predicts the future need for RRT successfully. This tool may help improve timing of therapy and prognosis in ICU patients.
authors.affiliation: Applied Mathematical Physiology (AMP) Lab, Department of Anesthesiology and Intensive Care Medicine, University of Bonn Medical Center, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Erdfelder
authors.affiliation: Applied Mathematical Physiology (AMP) Lab, Department of Anesthesiology and Intensive Care Medicine, University of Bonn Medical Center, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Grigutsch
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, University of Bonn Medical Center, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Hoeft
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine and Pain, Tel Aviv Medical Center, Weizmann 6, 64239, Tel Aviv, Israel.
authors.forename: Evgeny
authors.initials: E
authors.lastname: Reider
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine and Pain, Tel Aviv Medical Center, Weizmann 6, 64239, Tel Aviv, Israel.
authors.forename: Idit
authors.initials: I
authors.lastname: Matot
authors.affiliation: Applied Mathematical Physiology (AMP) Lab, Department of Anesthesiology and Intensive Care Medicine, University of Bonn Medical Center, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. zenker@uni-bonn.de.
authors.forename: Sven
authors.initials: S
authors.lastname: Zenker
mesh_terms: D058186:Acute Kidney Injury / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D002138:Calibration; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D003422:Critical Care / Q000379:methods*; D020000:Decision Support Systems, Clinical; D016002:Discriminant Analysis; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D009862:Online Systems; D010343:Patient Admission; D011336:Probability; D011379:Prognosis; D012372:ROC Curve; D017582:Renal Replacement Therapy / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult
chemical_list: D003404:Creatinine
keywords: Acute kidney injury; Decision support techniques; Online prediction; Renal replacement therapy