title: Gadolinium-based contrast agents: did we miss something in the last 25 years?
abstract: In the last 24 months, several clinical and experimental studies, suggested first and demonstrated later, a progressive concentration of Gadolinium in the brain of normal renal function patients, following repeated injections of some of the commercially approved Gadolinium-Based Contrast Agents. Although, till now, Gadolinium brain deposits have not been associated to any kind of neurological signs or symptoms, they oblige the radiology community to modify the actual approach in using Gadolinium contrast media in daily practice, to reduce unknown possible risks for patients.
authors.affiliation: Department of Medicine, Unit of Diagnostic Imaging, Università Campus Bio-Medico di Roma, via Alvàro del Portillo 21, 00128, Rome, Italy. b.zobel@unicampus.it.
authors.forename: Bruno
authors.initials: B
authors.lastname: Beomonte Zobel
authors.affiliation: Department of Medicine, Unit of Diagnostic Imaging, Università Campus Bio-Medico di Roma, via Alvàro del Portillo 21, 00128, Rome, Italy.
authors.forename: Carlo Cosimo
authors.initials: CC
authors.lastname: Quattrocchi
authors.affiliation: Department of Medicine, Unit of Diagnostic Imaging, Università Campus Bio-Medico di Roma, via Alvàro del Portillo 21, 00128, Rome, Italy.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Errante
authors.affiliation: Department of Medicine, Unit of Diagnostic Imaging, Università Campus Bio-Medico di Roma, via Alvàro del Portillo 21, 00128, Rome, Italy.
authors.forename: Rosario Francesco
authors.initials: RF
authors.lastname: Grasso
mesh_terms: D001921:Brain / Q000378:metabolism*; D003287:Contrast Media / Q000378:metabolism*; D005682:Gadolinium / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging
chemical_list: D003287:Contrast Media; D005682:Gadolinium
keywords: Chronic contrast adverse reaction; Contrast agents; Gadolinium; Human brain accumulation; Magnetic resonance; Safety; Trace elements