title: An Improved System for the Aqueous Lipshutz-Negishi Cross-Coupling of Alkyl Halides with Aryl Electrophiles.
abstract: The development of a palladacyclic precatalyst supported by a new biaryl(dialkyl)phosphine ligand (VPhos) in combination with octanoic acid/sodium octanoate as a simple and effective surfactant system provided an improved catalyst system for the rapid construction of a broad spectrum of alkylated scaffolds from alkyl zinc reagents generated in situ.
authors.affiliation: Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Vasudev R
authors.identifier: http://orcid.org/0000-0001-6602-6500
authors.initials: VR
authors.lastname: Bhonde
authors.affiliation: Pfizer Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Groton, CT, 06340, USA.
authors.forename: Brian T
authors.initials: BT
authors.lastname: O'Neill
authors.affiliation: Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. sbuchwal@mit.edu.
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D006219:Halogens / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D006219:Halogens; D014867:Water
keywords: alkyl zinc reagents; cross-coupling; micelles; palladium precatalysts; surfactants