title: Two new bicyclic sulfoxides from Welsh onion.
abstract: Newly identified bicyclic sulfoxides, welsonins A1 (1) and A2 (2), were isolated from acetone extracts of the bulbs of the Welsh onion (Allium fistulosum). In this study, the structures of 1 and 2, which are tetrahydrothiophene-S-oxide derivatives, were characterized by spectroscopic analysis. These compounds appeared to be derived from the coupling of 1-propenyl sulfenic acid and uronic acid. Welsonin A1 (1) showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of alternatively activated M2 macrophages.
authors.affiliation: Faculty of Pharmaceutical Sciences, Sojo University, 22-1, 4-Chome, Nishi-ku, Ikeda, Kumamoto, 860-0082, Japan. none@ph.sojo-u.ac.jp.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nohara
authors.affiliation: Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Fujiwara
authors.affiliation: Faculty of Pharmaceutical Sciences, Sojo University, 22-1, 4-Chome, Nishi-ku, Ikeda, Kumamoto, 860-0082, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ikeda
authors.affiliation: Faculty of Pharmaceutical Sciences, Sojo University, 22-1, 4-Chome, Nishi-ku, Ikeda, Kumamoto, 860-0082, Japan.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Murakami
authors.affiliation: School of Agriculture, Tokai University, 5435 Minamiaso, Aso, Kumamoto, 869-1404, Japan.
authors.forename: Masateru
authors.initials: M
authors.lastname: Ono
authors.affiliation: Faculty of Pharmacy, Tanta University, Tanta, 31111, Egypt.
authors.forename: Mona
authors.initials: M
authors.lastname: El-Aasr
authors.affiliation: Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakano
authors.affiliation: Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.
authors.forename: Junei
authors.initials: J
authors.lastname: Kinjo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D008264:Macrophages / Q000187:drug effects; D009369:Neoplasms; D019697:Onions / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D013454:Sulfoxides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013876:Thiophenes / Q000032:analysis
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D013454:Sulfoxides; D013876:Thiophenes; C000611401:welsonin A1; C000611402:welsonin A2; C121030:tetrahydrothiophene
keywords: Allium fistulosum; Anticancer function; Bicyclic sulfoxide; M2 macrophage; Tetrahydrothiophene derivative; Welsonin A1