title: A meta-analysis to determine the effect of pharmacological and non-pharmacological treatments on fibromyalgia symptoms comprising OMERACT-10 response criteria.
abstract: Fibromyalgia is characterized by widespread pain, sleep problems, fatigue, functional impairment, psychological distress, and cognitive dysfunction. The objective of this meta-analysis is to synthesize the available data on the effectiveness of pharmacological and non-pharmacological interventions across all domains included in the Outcome Measures in Rheumatology Clinical Trials (OMERACT-10) fibromyalgia response definitions, and to examine response based on these definitions. We searched Cochrane, PubMed, Scopus, and the reference lists of articles for randomized controlled trials of any drug formulation or non-pharmacological intervention used for fibromyalgia treatment. We extracted efficacy data regarding pain, sleep, physical function, fatigue, anxiety, depression, and cognition. The available data were insufficient to draw definite conclusions regarding response. Indirect evidence indicates that it may be expected with the use of serotonin noradrenaline reuptake inhibitors (SNRIs), noradrenaline reuptake inhibitors (NRIs), and multidisciplinary treatment.
authors.affiliation: Pain Relief and Palliative Care Unit, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece. papadopould@med.uoa.gr.
authors.forename: Despoina
authors.initials: D
authors.lastname: Papadopoulou
authors.affiliation: National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Argyro
authors.initials: A
authors.lastname: Fassoulaki
authors.affiliation: Institute for Continuing Medical Education of Ioannina, Ioannina, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Tsoulas
authors.affiliation: Pain Relief and Palliative Care Unit, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Ioanna
authors.initials: I
authors.lastname: Siafaka
authors.affiliation: Pain Relief and Palliative Care Unit, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Athina
authors.initials: A
authors.lastname: Vadalouca
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D005081:Exercise Therapy; D005356:Fibromyalgia / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D006801:Humans; D009125:Muscle Relaxants, Central / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D009125:Muscle Relaxants, Central
keywords: Fibromyalgia; Meta-analysis; Response; Treatment effect