title: Small Cell Lung Cancer Accompanied by Tonsillar Metastasis and Anti-Hu Antibody-Associated Paraneoplastic Neuropathy: A Rare Case Report With Long-Term Survival.
abstract: Tonsillar metastatic small cell lung cancer (SCLC) is rare, while anti-Hu antibodies are frequently found in SCLC. A 66-year-old man was admitted to our hospital with painful dysesthesia and muscle weakness in the distal extremities for over 1 year, progressive dysphagia for over 1 month, and severe cough and dyspnea for over 1 week. He was diagnosed with SCLC accompanied by tonsillar metastasis and anti-Hu antibody-associated paraneoplastic sensory neuropathy (PSN). The patient tolerated 6 cycles of sequential chemoradiotherapy and gradually recovered. The patient's disease remained in remission 2 years after the diagnosis with a remarkable reduction of tumor burden and a persisting high titer of anti-Hu antibodies. To our knowledge, this is the first case of tonsillar metastatic SCLC accompanied by anti-Hu antibody-associated PSN, whereby the anticancer immune response was presumed to play a vital role in disease control. Unilateral tonsillar metastasis of SCLC accompanied by anti-Hu antibody-associated PSN can occur and in certain circumstances, may have a favorable prognosis.
authors.affiliation: From the Department of Medical Oncology (JN, LW), Department of Neurology (ML), Department of Otolaryngology (HY); and Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (YW).
authors.forename: Jianjiao
authors.initials: J
authors.lastname: Ni
authors.forename: Linqian
authors.initials: L
authors.lastname: Weng
authors.forename: Mingsheng
authors.initials: M
authors.lastname: Liu
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.forename: Yingyi
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000368:Aged; D000906:Antibodies / Q000378:metabolism*; D051959:ELAV Proteins / Q000276:immunology*; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008297:Male; D020364:Paraneoplastic Polyneuropathy / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D055752:Small Cell Lung Carcinoma / Q000276:immunology / Q000378:metabolism / Q000556:secondary*; D014067:Tonsillar Neoplasms / Q000276:immunology / Q000378:metabolism / Q000556:secondary*
chemical_list: D000906:Antibodies; D051959:ELAV Proteins