title: Multiplex in vitro detection using SERS.
abstract: The ability to detect multiple disease-related targets from a single biological sample in a quick and reliable manner is of high importance in diagnosing and monitoring disease. The technique known as surface enhanced Raman scattering (SERS) has been developed for the simultaneous detection of multiple targets present in biological samples. Advances in the SERS method have allowed for the sensitive and specific detection of biologically relevant targets, such as DNA and proteins, which could be useful for the detection and control of disease. This review focuses on the strengths of SERS for the detection of target molecules from complex mixtures and the clinical relevance of recent work combining SERS with multiplexed detection of biological targets.
authors.affiliation: Centre for Molecular Nanometrology, WestCHEM, Pure and Applied Chemistry, University of Strathclyde, Technology and Innovation Centre, 99 George Street, Glasgow, G1 1RD, UK. karen.faulds@strath.ac.uk.
authors.forename: Stacey
authors.initials: S
authors.lastname: Laing
authors.affiliation: Centre for Molecular Nanometrology, WestCHEM, Pure and Applied Chemistry, University of Strathclyde, Technology and Innovation Centre, 99 George Street, Glasgow, G1 1RD, UK. karen.faulds@strath.ac.uk.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Gracie
authors.affiliation: Centre for Molecular Nanometrology, WestCHEM, Pure and Applied Chemistry, University of Strathclyde, Technology and Innovation Centre, 99 George Street, Glasgow, G1 1RD, UK. karen.faulds@strath.ac.uk.
authors.forename: Karen
authors.initials: K
authors.lastname: Faulds
mesh_terms: D004247:DNA / Q000032:analysis*; D003952:Diagnostic Imaging; D004194:Disease; D006801:Humans; D011506:Proteins / Q000032:analysis*; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013499:Surface Properties
chemical_list: D011506:Proteins; D004247:DNA