title: Diagnosis value of CD117 and PDGFRA, alone or in combination DOG1, as biomarkers for gastrointestinal stromal tumors.
abstract: BACKGROUND
  To explore the diagnostic values of CD117 and PDGFRA protein expressions, used alone or in combination with DOG1 protein, for gastrointestinal stromal tumors (GIST).
  
  
  METHODS
  The CD117, PDGFRA and DOG1 protein expressions in 99 GIST specimens and 25 non-GIST specimens were retrospectively determined, and the potential correlations were analyzed.
  
  
  RESULTS
  The positive rates of CD117, PDGFRA, and DOG1 expressions were 93.94% (93/99), 53.54% (53/99), and 90.91% (90/99) in GIST group and 4.00% (1/25), 4.00% (1/25), and 12.00% (3/25) in non-GIST group (all P<0.05). The expressions of CD117, PDGFRA, and DOG1 had no significant correlation with clinicopathological parameters including gender, age, tumor diameter, tumor location, histotype, and risk degree (all P>0.05). The sensitivities of CD117, PDGFRA, DOG1, CD117 + DOG1, PDGFRA + DOG1, and CD117 + PDGFRA + DOG1 were 0.989, 0.981, 0.968, 0.960, 0.933, and 0.961 in judging GIST, respectively, and the specificities were 0.800, 0.343, 0.710, 0.840, 0.947, and 0.955, respectively. The areas under the ROC curve (AUC) in these six groups were 0.945, 0.748, 0.895, 0.895, 0.840, and 0.975, respectively.
  
  
  CONCLUSIONS
  The populations that may benefit more from the detection of CD117, PDGFRA, and DOG1 protein expression for GIST need to be further identified. Detection of CD117 and PDGFRA protein, alone or in combination with DOG1, may increase the accuracy of GIST diagnosis.
authors.affiliation: 1 Department of Pathology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China ; 2 Department of Pathology, the Military General Hospital of Beijing PLA, Beijing 100700, China.
authors.forename: Chunwei
authors.initials: C
authors.lastname: Xu
authors.affiliation: 1 Department of Pathology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China ; 2 Department of Pathology, the Military General Hospital of Beijing PLA, Beijing 100700, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Han
authors.affiliation: 1 Department of Pathology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China ; 2 Department of Pathology, the Military General Hospital of Beijing PLA, Beijing 100700, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Wang
authors.affiliation: 1 Department of Pathology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China ; 2 Department of Pathology, the Military General Hospital of Beijing PLA, Beijing 100700, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.affiliation: 1 Department of Pathology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China ; 2 Department of Pathology, the Military General Hospital of Beijing PLA, Beijing 100700, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Shao
authors.affiliation: 1 Department of Pathology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China ; 2 Department of Pathology, the Military General Hospital of Beijing PLA, Beijing 100700, China.
authors.forename: Liying
authors.initials: L
authors.lastname: Zhang
authors.affiliation: 1 Department of Pathology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China ; 2 Department of Pathology, the Military General Hospital of Beijing PLA, Beijing 100700, China.
authors.forename: Huaitao
authors.initials: H
authors.lastname: Wang
authors.affiliation: 1 Department of Pathology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China ; 2 Department of Pathology, the Military General Hospital of Beijing PLA, Beijing 100700, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Wang
authors.affiliation: 1 Department of Pathology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China ; 2 Department of Pathology, the Military General Hospital of Beijing PLA, Beijing 100700, China.
authors.forename: Yongfang
authors.initials: Y
authors.lastname: Wu
authors.affiliation: 1 Department of Pathology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China ; 2 Department of Pathology, the Military General Hospital of Beijing PLA, Beijing 100700, China.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Li
authors.affiliation: 1 Department of Pathology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China ; 2 Department of Pathology, the Military General Hospital of Beijing PLA, Beijing 100700, China.
authors.forename: Ruiming
authors.initials: R
authors.lastname: Li
authors.affiliation: 1 Department of Pathology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China ; 2 Department of Pathology, the Military General Hospital of Beijing PLA, Beijing 100700, China.
authors.forename: Yuwang
authors.initials: Y
authors.lastname: Tian
keywords: CD117; DOG1; Gastrointestinal stromal tumors (GIST); PDGFRA; diagnosis