title: Reflectin as a Material for Neural Stem Cell Growth.
abstract: Cephalopods possess remarkable camouflage capabilities, which are enabled by their complex skin structure and sophisticated nervous system. Such unique characteristics have in turn inspired the design of novel functional materials and devices. Within this context, recent studies have focused on investigating the self-assembly, optical, and electrical properties of reflectin, a protein that plays a key role in cephalopod structural coloration. Herein, we report the discovery that reflectin constitutes an effective material for the growth of human neural stem/progenitor cells. Our findings may hold relevance both for understanding cephalopod embryogenesis and for developing improved protein-based bioelectronic devices.
authors.affiliation: Department of Chemical Engineering and Materials Science, University of California, Irvine , Irvine, California 92697, United States.
authors.forename: Long
authors.initials: L
authors.lastname: Phan
authors.affiliation: Department of Chemical Engineering and Materials Science, University of California, Irvine , Irvine, California 92697, United States.
authors.forename: Rylan
authors.initials: R
authors.lastname: Kautz
authors.affiliation: Department of Biomedical Engineering, University of California, Irvine , Irvine, California 92697, United States.|Sue and Bill Gross Stem Cell Research Center, University of California, Irvine , Irvine, California 92697, United States.
authors.forename: Janahan
authors.initials: J
authors.lastname: Arulmoli
authors.affiliation: Department of Physiology and Biophysics, University of California, Irvine , Irvine, California 92697, United States.
authors.forename: Iris H
authors.initials: IH
authors.lastname: Kim
authors.affiliation: Department of Physiology and Biophysics, University of California, Irvine , Irvine, California 92697, United States.
authors.forename: Dai Trang T
authors.initials: DT
authors.lastname: Le
authors.affiliation: Department of Chemical Engineering and Materials Science, University of California, Irvine , Irvine, California 92697, United States.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Shenk
authors.affiliation: Department of Physiology and Biophysics, University of California, Irvine , Irvine, California 92697, United States.
authors.forename: Medha M
authors.initials: MM
authors.lastname: Pathak
authors.affiliation: Department of Biomedical Engineering, University of California, Irvine , Irvine, California 92697, United States.|Sue and Bill Gross Stem Cell Research Center, University of California, Irvine , Irvine, California 92697, United States.|Department of Neurology, University of California, Irvine , Irvine, California 92697, United States.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Flanagan
authors.affiliation: Department of Physiology and Biophysics, University of California, Irvine , Irvine, California 92697, United States.
authors.forename: Francesco
authors.initials: F
authors.lastname: Tombola
authors.affiliation: Department of Chemical Engineering and Materials Science, University of California, Irvine , Irvine, California 92697, United States.|Department of Chemistry, University of California, Irvine , Irvine, California 92697, United States.
authors.forename: Alon A
authors.initials: AA
authors.lastname: Gorodetsky
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000187:drug effects; D001672:Biocompatible Materials / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D049832:Decapodiformes / Q000737:chemistry; D006801:Humans; D008856:Microscopy, Fluorescence; D058953:Neural Stem Cells / Q000166:cytology* / Q000187:drug effects; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D011506:Proteins / Q000494:pharmacology*
chemical_list: D001672:Biocompatible Materials; D011506:Proteins
keywords: bioelectronics; biointerfaces; cephalopods; reflectin; stem cells