title: Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trial.
abstract: OBJECTIVE
  To evaluate whether myo-inositol supplementation may reduce gestational diabetes mellitus (GDM) rate in overweight women.
  
  
  METHODS
  In an open-label, randomized trial, myo-inositol (2 g plus 200 μg folic acid twice a day) or placebo (200 μg folic acid twice a day) was administered from the first trimester to delivery in pregnant overweight non-obese women (pre-pregnancy body mass index ≥ 25 and < 30 kg/m(2)). The primary outcome was the incidence of GDM.
  
  
  RESULTS
  From January 2012 to December 2014, 220 pregnant women were randomized at two Italian University hospitals, 110 to myo-inositol and 110 to placebo. The incidence of GDM was significantly lower in the myo-inositol group compared to the placebo group (11.6% versus 27.4%, respectively, p = 0.004). Myo-inositol treatment was associated with a 67% risk reduction of developing GDM (OR 0.33; 95% CI 0.15-0.70).
  
  
  CONCLUSIONS
  Myo-inositol supplementation, administered since early pregnancy, reduces GDM incidence in overweight non-obese women.
authors.affiliation: a Department of Pediatrics , Gynecology, Microbiology and Biomedical Sciences, University of Messina , Messina , Italy .
authors.forename: Angelo
authors.initials: A
authors.lastname: Santamaria
authors.affiliation: b Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy , and.
authors.forename: Antonino
authors.initials: A
authors.lastname: Di Benedetto
authors.affiliation: c Obstetric Unit, Mother-Infant Department, University of Modena and Reggio Emilia , Modena , Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Petrella
authors.affiliation: b Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy , and.
authors.forename: Basilio
authors.initials: B
authors.lastname: Pintaudi
authors.affiliation: a Department of Pediatrics , Gynecology, Microbiology and Biomedical Sciences, University of Messina , Messina , Italy .
authors.forename: Francesco
authors.initials: F
authors.lastname: Corrado
authors.affiliation: a Department of Pediatrics , Gynecology, Microbiology and Biomedical Sciences, University of Messina , Messina , Italy .
authors.forename: Rosario
authors.initials: R
authors.lastname: D'Anna
authors.affiliation: c Obstetric Unit, Mother-Infant Department, University of Modena and Reggio Emilia , Modena , Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Neri
authors.affiliation: c Obstetric Unit, Mother-Infant Department, University of Modena and Reggio Emilia , Modena , Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Facchinetti
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000517:prevention & control*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D015994:Incidence; D007294:Inositol / Q000627:therapeutic use*; D050177:Overweight; D011247:Pregnancy; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D014803:Vitamin B Complex; D007294:Inositol
keywords: Body mass index; gestational diabetes; myo-inositol; obese; overweight