title: Serum adiponectin level in obstructive sleep apnea: Relation of adiponectin to obesity and long-term continuous positive airway pressure therapy.
abstract: OBJECTIVE
  The study aimed to determine the effect of OSA and obesity on the plasma levels of adiponectin and the long-term effect of CPAP on its plasma levels and obesity parameters.
  
  
  METHODS
  A prospective observational study included 159 newly diagnosed OSA patients. The cohort was divided into CPAP treated (n=82) and control group (n=77). Both groups were examined at the beginning and a year later. The CPAP-treated patients were additionally tested after a month of therapy. The examinations included Epworth Sleepiness Scale questionnaire, anthropometric and polysomnographic measurements, and blood serum tests. Changes in the studied parameters of OSA, obesity, and adiponectin obtained at the beginning and after follow-up period were compared in each group.
  
  
  RESULTS
  In CPAP group, all studied OSA parameters improved already after a month of CPAP therapy. Contrarily, obesity parameters (except of neck and waist circumference) remained unchanged after CPAP therapy. Serum adiponectin levels dropped during CPAP therapy. In the control group, both obesity and OSA parameters did not show changes. The only exceptions were deteriorated mean SpO2 and decreased hip circumference. Adiponectin remained unchanged in this group. In neither group, the Spearman correlation analyses showed any association of serum adiponectin levels with obesity or OSA parameters, except of mean SpO2.
  
  
  CONCLUSIONS
  Only correlation found was between adiponectin and mean SpO2. Although CPAP therapy improves all OSA parameters, it did not change most obesity parameters. Additionally in the CPAP group, there was a significant drop in adiponectin levels, suggesting its protective role in this group of patients.
authors.affiliation: Department of Respiratory Medicine, University Hospital and Palacky University Olomouc, Olomouc, Czech Republic. Electronic address: milada.hobzova@seznam.cz.
authors.forename: Milada
authors.initials: M
authors.lastname: Hobzová
authors.affiliation: Department of Otorhinolaryngology, Olomouc University Hospital and Palacky University Olomouc, Olomouc, Czech Republic.
authors.forename: Richard
authors.initials: R
authors.lastname: Salzman
authors.affiliation: Department of Medical Chemistry and Biochemistry, Palacky University Olomouc, Olomouc, Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Stejskal
authors.affiliation: Department of Medical Biophysics, Palacky University Olomouc, Olomouc, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Zapletalová
authors.affiliation: Department of Respiratory Medicine, University Hospital and Palacky University Olomouc, Olomouc, Czech Republic.
authors.forename: Vítězslav
authors.initials: V
authors.lastname: Kolek
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D045422:Continuous Positive Airway Pressure; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications*; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications / Q000628:therapy*; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin
keywords: Adiponectin; Continuous positive airway pressure; Obesity; Obstructive sleep apnea; Oxygen saturation