title: Correlation between erythropoietin serum levels and erythrocyte susceptibility to lipid peroxidation in elderly with type 2 diabetes.
abstract: Erythropoietin (EPO), a key hormone involved in red blood cell formation has been recently acknowledged for its pleiotropic actions and protective role in ageing and various pathological conditions concurrent with oxidative stress, vascular diseases and metabolic abnormalities such as diabetes mellitus. The aim of the study was to evaluate the relationship between circulating erythropoietin levels and oxidative stress biomarkers, in elderly with type 2 diabetes (T2DM). The study was carried out in 67 subjects with T2DM (69 ± 5 years; n = 37) without anemia, and aged-matched controls (70 ± 6 years; n = 30). EPO serum levels, erythrocyte susceptibility to lipid peroxidation (ESP) and total antioxidant capacity (TAC) were evaluated. Lower EPO levels (p < 0.01) and higher ESP values (p < 0.001) were found in T2DM group, compared to healthy subjects. EPO levels showed significant negative associations with ESP, both in T2DM subjects (r = -0.565; p < 0.001) and in all study population (r = -0,600; p < 0,001; n = 67). In conclusion, we provide new data regarding the cytoprotective effect of EPO exerted at systemic level on erythrocyte membrane, in the particular state of impaired glucose metabolism associated with oxidative stress, in the elderly.
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Carol Davila-University of Medicine and Pharmacy , 6 Taian Vuia street, sector 2, 020956, Bucharest , Romania.|Ana Aslan-National Institute of Gerontology and Geriatrics , Bucharest , Romania.
authors.forename: D
authors.initials: D
authors.lastname: Gradinaru
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Carol Davila-University of Medicine and Pharmacy , 6 Taian Vuia street, sector 2, 020956, Bucharest , Romania.
authors.forename: D
authors.initials: D
authors.lastname: Margina
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Carol Davila-University of Medicine and Pharmacy , 6 Taian Vuia street, sector 2, 020956, Bucharest , Romania.
authors.forename: M
authors.initials: M
authors.lastname: Ilie
authors.affiliation: Ana Aslan-National Institute of Gerontology and Geriatrics , Bucharest , Romania.
authors.forename: C
authors.initials: C
authors.lastname: Borsa
authors.affiliation: Ana Aslan-National Institute of Gerontology and Geriatrics , Bucharest , Romania.
authors.forename: C
authors.initials: C
authors.lastname: Ionescu
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Carol Davila-University of Medicine and Pharmacy , 6 Taian Vuia street, sector 2, 020956, Bucharest , Romania.|Ana Aslan-National Institute of Gerontology and Geriatrics , Bucharest , Romania.
authors.forename: G I
authors.initials: GI
authors.lastname: Prada
mesh_terms: D000368:Aged; D000740:Anemia; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D004921:Erythropoietin; D005947:Glucose
keywords: ageing; erythropoietin; lipid peroxidation; oxidative stress; type 2 diabetes