title: A Patient With Pansynostosis and Williams-Beuren Syndrome.
abstract: BACKGROUND
  Williams-Beuren syndrome (WBS) is a multisystemic genetic disorder caused by a gene deletion at gene locus 7q11.23. This article presents the first described case of a patient with WBS and simultaneous pansynostosis.
  
  
  METHODS
  This article presents the management of this young Caucasian boy from birth until the age of 12 years and provides an overview of previously described manifestations of WBS in the craniofacial region.
  
  
  CONCLUSIONS
  This case demonstrates the surgical treatment of pansynostosis in a child with WBS and might provide interesting aspects in the diagnostics and management of this rare malformation.
authors.affiliation: Department of Oral and Cranio-Maxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: Katinka
authors.initials: K
authors.lastname: Kansy
authors.forename: Christian
authors.initials: C
authors.lastname: Freudlsperger
authors.forename: Jürgen
authors.initials: J
authors.lastname: Hoffmann
authors.forename: Michael
authors.initials: M
authors.lastname: Engel
mesh_terms: D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D003398:Craniosynostoses / Q000175:diagnosis* / Q000601:surgery; D003399:Craniotomy / Q000379:methods; D005500:Follow-Up Studies; D005624:Frontal Bone / Q000002:abnormalities / Q000601:surgery; D017353:Gene Deletion; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009915:Orbit / Q000002:abnormalities / Q000601:surgery; D012086:Reoperation; D014057:Tomography, X-Ray Computed / Q000379:methods; D018980:Williams Syndrome / Q000175:diagnosis* / Q000235:genetics