title: FASTmC: A Suite of Predictive Models for Nonreference-Based Estimations of DNA Methylation.
abstract: We describe a suite of predictive models, coined FAST(m)C, for nonreference, cost-effective exploration and comparative analysis of context-specific DNA methylation levels. Accurate estimations of true DNA methylation levels can be obtained from as few as several thousand short-reads generated from whole-genome bisulfite sequencing. These models make high-resolution time course or developmental and large diversity studies practical regardless of species, genome size, and availability of a reference genome.
authors.affiliation: Department of Genetics, University of Georgia, Athens, Georgia 30602.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Bewick
authors.affiliation: Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602.
authors.forename: Brigitte T
authors.initials: BT
authors.lastname: Hofmeister
authors.affiliation: Department of Genetics, University of Georgia, Athens, Georgia 30602.
authors.forename: Kevin
authors.initials: K
authors.lastname: Lee
authors.affiliation: Department of Plant Biology, University of Georgia, Athens, Georgia 30602.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Genetics, University of Georgia, Athens, Georgia 30602.
authors.forename: David W
authors.initials: DW
authors.lastname: Hall
authors.affiliation: Department of Genetics, University of Georgia, Athens, Georgia 30602 schmitz@uga.edu.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Schmitz
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods*; D018899:CpG Islands; D019175:DNA Methylation; D030561:Databases, Nucleic Acid; D044127:Epigenesis, Genetic; D057890:Epigenomics / Q000379:methods*; D020869:Gene Expression Profiling; D055106:Genome-Wide Association Study; D006801:Humans; D012984:Software
keywords: DNA methylation; epigenetics; methylome; modeling; whole-genome bisulfite sequencing