title: Serum Chromium Levels in Type 2 Diabetic Patients and Its Association with Glycaemic Control.
abstract: BACKGROUND
  Chromium is an essential micronutrient which is required for the normal functioning of insulin and regulation of blood sugar levels. It acts as a vital antioxidant for maintaining insulin homeostasis. In diabetes mellitus, the free radical production is increased and levels of antioxidants like chromium, vanadium, selenium and manganese are reduced. There have been previous studies to suggest that low serum levels of chromium are associated with poorer glycaemic control.
  
  
  OBJECTIVE
  To study the level of serum chromium in newly diagnosed patients with type 2 diabetes mellitus and its association with glycaemic control.
  
  
  METHODS
  Serum chromium concentration was determined by using inductively coupled Plasma - Optical Emission Spectophotometry in 42 newly diagnosed type 2 diabetes mellitus patients without any pre-existing complications. They were divided into 2 groups - well controlled (HbA1c ≤7.0%) and uncontrolled groups (HbA1c >7.0%).
  
  
  RESULTS
  Mean serum chromium concentration measured in uncontrolled type 2 diabetic patients was significantly lower (0.065 ± 0.03 mcg/L vs 0.103 ± 0.04 mcg/L, p< 0.05). There was a statistically significant inverse linear correlation of the HbA1c values and the serum chromium concentration (r= -0.6514, p < 0.0001). There was also a decrease in chromium levels across both the groups with advancing age and the decrease being significant beyond 40 years of age (p<0.05).
  
  
  CONCLUSIONS
  The results of our study describes the relationship between serum chromium levels and control of type 2 diabetes mellitus. Significant reduction in chromium levels are probable indicators of metabolic response to oxidative stress in patients with type 2 diabetes mellitus. Further large scale studies relating serum chromium and type 2 diabetes mellitus may help to understand more about the exact relationship.
authors.affiliation: Associate Professor Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University , Thandalam, Chennai, Tamilnadu, India .
authors.forename: Kannan
authors.initials: K
authors.lastname: Rajendran
authors.affiliation: Assistant Professor, Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University , Thandalam, Chennai, Tamilnadu, India .
authors.forename: Senthil
authors.initials: S
authors.lastname: Manikandan
authors.affiliation: Assistant Professor, Department of Pediatrics, Saveetha Medical College & Hospital, Saveetha University , Thandalam, Chennai, Tamilnadu, India .
authors.forename: Lal Devayanivasudevan
authors.initials: LD
authors.lastname: Nair
authors.affiliation: Professor, Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University , Thandalam, Chennai, Tamilnadu, India .
authors.forename: Rajendran
authors.initials: R
authors.lastname: Karuthodiyil
authors.affiliation: Interns, Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University , Thandalam, Chennai, Tamilnadu, India .
authors.forename: Nikhilan
authors.initials: N
authors.lastname: Vijayarajan
authors.affiliation: Interns, Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University , Thandalam, Chennai, Tamilnadu, India .
authors.forename: Rajiv
authors.initials: R
authors.lastname: Gnanasekar
authors.affiliation: Interns, Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University , Thandalam, Chennai, Tamilnadu, India .
authors.forename: Vivian V
authors.initials: VV
authors.lastname: Kapil
authors.affiliation: Interns, Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University , Thandalam, Chennai, Tamilnadu, India .
authors.forename: Azeem S
authors.initials: AS
authors.lastname: Mohamed
keywords: Hyperglycemia; Microvascular complications; Retinopathy