title: Clinical characteristics and in hospital outcomes of heart transplant recipients with allograft vasculopathy undergoing percutaneous coronary intervention: Insights from the National Cardiovascular Data Registry.
abstract: BACKGROUND
  Cardiac allograft vasculopathy is a major cause of morbidity and mortality following heart transplantation. Large multicenter studies evaluating the clinical characteristics and inhospital outcomes of heart transplant recipients undergoing percutaneous coronary intervention (PCI) are lacking.
  
  
  OBJECTIVE
  To evaluate the clinical characteristics, treatment patterns and inhospital outcomes of heart transplant recipients undergoing PCI compared to general population.
  
  
  METHODS
  We analyzed 1,897,328 patients from the National Cardiovascular Data Registry CathPCI registry who underwent PCI of at least 1 native vessel between July 2009 and December 2013 from 1,477 centers, of which 542 patients (0.03%) were heart transplant recipients. Clinical characteristics were evaluated and, after 1:4 propensity matching, inhospital outcomes were compared between 538 heart transplant patients and 2,128 non-transplant patients.
  
  
  RESULTS
  Transplant recipients undergoing PCI had a higher prevalence of diabetes, dyslipidemia and peripheral vascular disease; lower prevalence of angina, acute coronary syndrome, abnormal noninvasive functional study, and type C coronary lesions compared to the non-transplant PCI population. After propensity matching, all-cause inhospital mortality was similar between transplant and non-transplant groups (1.3% vs 1.0%; OR, 1.21; 95% CI, 0.54-2.67).
  
  
  CONCLUSIONS
  This is the largest series to date outlining the characteristics of heart transplant recipients undergoing PCI. Similar inhospital outcomes were noted in heart transplant recipients compared to the general population. Further studies evaluating long-term outcomes are warranted.
authors.affiliation: Division of Cardiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK. Electronic address: tarun-dasari@ouhsc.edu.
authors.forename: Tarun W
authors.initials: TW
authors.lastname: Dasari
authors.affiliation: Division of Cardiology, Northshore University Health System, Evanston, IL.
authors.forename: Jorge F
authors.initials: JF
authors.lastname: Saucedo
authors.affiliation: John Ochsner Heart and Vascular Institute, Ochsner Clinic Foundation, New Orleans, LA.
authors.forename: Selim
authors.initials: S
authors.lastname: Krim
authors.affiliation: Cardiovascular Division, Temple University, Philadelphia, PA.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Alkhouli
authors.affiliation: Ahmanson-UCLA Cardiomyopathy Center, Ronald Reagan-UCLA Medical Center, Los Angeles, CA.
authors.forename: Gregg C
authors.initials: GC
authors.lastname: Fonarow
authors.affiliation: Cardiovascular Division, Temple University, Philadelphia, PA.
authors.forename: Rene
authors.initials: R
authors.lastname: Alvarez
authors.affiliation: Division of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, TX.
authors.forename: Homam
authors.initials: H
authors.lastname: Ibrahim
authors.affiliation: Duke University Medical Center and Duke Clinical Research Institute (DCRI), Durham, NC.
authors.forename: David
authors.initials: D
authors.lastname: Dai
authors.affiliation: Duke University Medical Center and Duke Clinical Research Institute (DCRI), Durham, NC.
authors.forename: Tracy Y
authors.initials: TY
authors.lastname: Wang
authors.affiliation: Division of Cardiovascular Medicine; UH Case Medical Center, Case Western Reserve University in Cleveland, OH.
authors.forename: Marco
authors.initials: M
authors.lastname: Costa
authors.affiliation: Vanderbilt University, Nashville, TN.
authors.forename: JoAnn
authors.initials: J
authors.lastname: Lindenfeld
authors.affiliation: Division of Cardiology, University of Colorado School of Medicine, Aurora, CO.
authors.forename: John C
authors.initials: JC
authors.lastname: Messenger
mesh_terms: D000328:Adult; D000368:Aged; D064591:Allografts / Q000098:blood supply / Q000473:pathology; D015897:Comorbidity; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology / Q000601:surgery; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D000069451:Long Term Adverse Effects / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D062645:Percutaneous Coronary Intervention / Q000379:methods / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000453:epidemiology / Q000601:surgery; D012042:Registries; D014481:United States / Q000453:epidemiology; D014652:Vascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000601:surgery