title: STANDARD CUT RATE 25-GAUGE VITRECTOMY VERSUS ULTRAHIGH-SPEED 25-GAUGE SYSTEM IN CORE VITRECTOMY: A Randomized Clinical Trial.
abstract: OBJECTIVE
  The aim of this study was to compare the efficiency and safety of ultrahigh-speed cut rate 25-gauge system and standard cut rate 25-gauge vitrectomy system.
  
  
  METHODS
  In this single-center, prospective randomized study, all consecutive eyes that underwent 25-gauge vitrectomy at the Eye Clinic of the University of Ancona from September 2014 to November 2014 were randomized to receive 25-gauge vitrectomy with 7,500 cuts per minute (cpm) probes (7,500 Group) or 25-gauge vitrectomy with 5,000 cpm probes (Standard Group). Exclusion criteria were previously vitrectomized eye, trauma cases, retinal detachment with proliferative vitreoretinopathy, and endophthalmitis. Main outcome measure was core vitrectomy duration. Secondary outcome was the incidence of iatrogenic retinal breaks and other complications related to surgery.
  
  
  RESULTS
  Overall, 62 eyes were enrolled; 31 eyes received 25-gauge 7,500 cpm vitrectomy and 31 eyes received 25-gauge 5,000 cpm vitrectomy. The duration of core vitrectomy was significantly lower in the 7,500 Group (P = 0.030, t-test for independent samples). Mean ± standard deviation core vitrectomy time was 161.32 ± 39.10 seconds in the 7,500 Group and 184.10 ± 41.69 seconds in the Standard Group. The observed difference in mean core vitrectomy duration between subjects treated with 7,500 cpm probes and those in the Standard Group was equal -22 seconds (95% confidence interval: -43.3 to -2.2). There was no difference in the incidence of iatrogenic breaks between the 2 groups, and there were no other complications over a 3-month follow-up period.
  
  
  CONCLUSIONS
  The 25-gauge 7,500 cpm vitrectomy is an effective and safe surgical procedure, and it can significantly reduce core vitrectomy time in eyes undergoing vitreoretinal surgery.
authors.affiliation: *Eye Clinic, Polytechnic University of Marche, Ancona, Italy; †Eye clinic, University Hospital "Ospedali Riuniti", Ancona, Italy; ‡Center of Epidemiology, Biostatistics and Medical Information Technology, Polytechnic University of Marche, Ancona, Italy; and §Department of Ophthalmology, University of Catania, Catania, Italy.
authors.forename: Cesare
authors.initials: C
authors.lastname: Mariotti
authors.forename: Michele
authors.initials: M
authors.lastname: Nicolai
authors.forename: Andrea
authors.initials: A
authors.lastname: Saitta
authors.forename: Emanuele
authors.initials: E
authors.lastname: Orsini
authors.forename: Francesca
authors.initials: F
authors.lastname: Viti
authors.forename: Edlira
authors.initials: E
authors.lastname: Skrami
authors.forename: Rosaria
authors.initials: R
authors.lastname: Gesuita
authors.forename: Michele
authors.initials: M
authors.lastname: Reibaldi
authors.forename: Alfonso
authors.initials: A
authors.lastname: Giovannini
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D019654:Lens Implantation, Intraocular; D008297:Male; D008866:Microsurgery / Q000379:methods; D061646:Operative Time; D018918:Phacoemulsification; D011446:Prospective Studies; D016896:Treatment Outcome; D014821:Vitrectomy / Q000295:instrumentation / Q000379:methods*; D057586:Vitreoretinal Surgery