title: Obesity-Related Chronic Kidney Disease-The Role of Lipid Metabolism.
abstract: Obesity is an independent risk factor for chronic kidney disease (CKD). The mechanisms linking obesity and CKD include systemic changes such as high blood pressure and hyperglycemia, and intrarenal effects relating to lipid accumulation. Normal lipid metabolism is integral to renal physiology and disturbances of renal lipid and energy metabolism are increasingly being linked with kidney disease. AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) are important regulators of fatty acid oxidation, which is frequently abnormal in the kidney with CKD. A high fat diet reduces renal AMPK activity, thereby contributing to reduced fatty acid oxidation and energy imbalance, and treatments to activate AMPK are beneficial in animal models of obesity-related CKD. Studies have found that the specific cell types affected by excessive lipid accumulation are proximal tubular cells, podocytes, and mesangial cells. Targeting disturbances of renal energy metabolism is a promising approach to addressing the current epidemic of obesity-related kidney disease.
authors.affiliation: Department of Nephrology, Austin Health, Heidelberg, Melbourne 3084, Australia. Peter.Mount@austin.org.au.|Department of Medicine, Austin Health, University of Melbourne, Heidelberg 3084, Australia. Peter.Mount@austin.org.au.|Institute for Breathing and Sleep, Austin Health, Heidelberg, Melbourne 3084, Australia. Peter.Mount@austin.org.au.
authors.forename: Peter
authors.initials: P
authors.lastname: Mount
authors.affiliation: Department of Nephrology, Austin Health, Heidelberg, Melbourne 3084, Australia. Matthew.Davies@austin.org.au.|Department of Medicine, Austin Health, University of Melbourne, Heidelberg 3084, Australia. Matthew.Davies@austin.org.au.|Institute for Breathing and Sleep, Austin Health, Heidelberg, Melbourne 3084, Australia. Matthew.Davies@austin.org.au.
authors.forename: Matthew
authors.initials: M
authors.lastname: Davies
authors.affiliation: Department of Nephrology, Austin Health, Heidelberg, Melbourne 3084, Australia. Suet-Wan.Choy@austin.org.au.|Department of Medicine, Austin Health, University of Melbourne, Heidelberg 3084, Australia. Suet-Wan.Choy@austin.org.au.
authors.forename: Suet-Wan
authors.initials: SW
authors.lastname: Choy
authors.affiliation: Department of Nephrology, Austin Health, Heidelberg, Melbourne 3084, Australia. Natasha.Cook@austin.org.au.
authors.forename: Natasha
authors.initials: N
authors.lastname: Cook
authors.affiliation: Department of Nephrology, Austin Health, Heidelberg, Melbourne 3084, Australia. David.Power@austin.org.au.|Department of Medicine, Austin Health, University of Melbourne, Heidelberg 3084, Australia. David.Power@austin.org.au.|Institute for Breathing and Sleep, Austin Health, Heidelberg, Melbourne 3084, Australia. David.Power@austin.org.au.
authors.forename: David
authors.initials: D
authors.lastname: Power
keywords: AMP-activated protein kinase; acetyl-CoA carboxylase; chronic kidney disease; high fat diet; lipid metabolism; mesangial cell; obesity; podocyte; proximal tubule