title: Racial and Ethnic Variations in Lung Cancer Incidence and Mortality: Results From the Women's Health Initiative.
abstract: OBJECTIVE
  This study aimed to evaluate racial/ethnic differences in lung cancer incidence and mortality in the Women's Health Initiative Study, a longitudinal prospective cohort evaluation of postmenopausal women recruited from 40 clinical centers.
  
  
  METHODS
  Lung cancer diagnoses were centrally adjudicated by pathology review. Baseline survey questionnaires collected sociodemographic and health information. Logistic regression models estimated incidence and mortality odds by race/ethnicity adjusted for age, education, calcium/vitamin D, body mass index, smoking (status, age at start, duration, and pack-years), alcohol, family history, oral contraceptive, hormones, physical activity, and diet.
  
  
  RESULTS
  The cohort included 129,951 women--108,487 (83%) non-Hispanic white (NHW); 10,892 (8%) non-Hispanic black (NHB); 4,882 (4%) Hispanic; 3,696 (3%) Asian/Pacific Islander (API); 534 (< 1%) American Indian/Alaskan Native; and 1,994 (1%) other. In unadjusted models, Hispanics had 66% lower odds of lung cancer compared with NHW (odds ratio [OR], 0.34; 95% CI, 0.2 to 0.5), followed by API (OR, 0.45; 95% CI, 0.27 to 0.75) and NHB (OR, 0.75; 95% CI, 0.59 to 0.95). In fully adjusted multivariable models, the decreased lung cancer risk for Hispanic compared with NHW women attenuated to the null (OR, 0.59; 95% CI, 0.35 to 0.99). In unadjusted models Hispanic and API women had decreased risk of death compared with NHW women (OR, 0.30 [95% CI, 0.15 to 0.62] and 0.34 [95% CI, 0.16 to 0.75, respectively); however, no racial/ethnic differences were found in risk of lung cancer death in fully adjusted models.
  
  
  CONCLUSIONS
  Differences in lung cancer incidence and mortality are associated with sociodemographic, clinical, and behavioral factors. These findings suggest modifiable exposures and behaviors may contribute to differences in incidence of and mortality by race/ethnicity for postmenopausal women. Interventions focused on these factors may reduce racial/ethnic differences in lung cancer incidence and mortality.
authors.affiliation: Manali I. Patel, Ange Wang, Kristopher Kapphahn, Manisha Desai, Marcia L. Stefanick, and Heather A. Wakelee, Stanford University School of Medicine; Marcia L. Stefanick, Stanford Prevention Research Center; Heather A. Wakelee, Stanford Cancer Institute, Stanford; Rowan T. Chlebowski, Harbor-University of California, Los Angeles, Medical Center, Torrance; Chloe E. Bird, RAND Corporation, Santa Monica; Scarlett Lin Gomez, Cancer Prevention Institute of California, Fremont, CA; Michael S. Simon and Michele L. Cote, Karmanos Cancer Institute Detroit, MI; Giselle Corbie-Smith, University of North Carolina, Chapel Hill, NC; and Lucile L. Adams-Campbell, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC. manalip@stanford.edu.
authors.forename: Manali I
authors.initials: MI
authors.lastname: Patel
authors.affiliation: Manali I. Patel, Ange Wang, Kristopher Kapphahn, Manisha Desai, Marcia L. Stefanick, and Heather A. Wakelee, Stanford University School of Medicine; Marcia L. Stefanick, Stanford Prevention Research Center; Heather A. Wakelee, Stanford Cancer Institute, Stanford; Rowan T. Chlebowski, Harbor-University of California, Los Angeles, Medical Center, Torrance; Chloe E. Bird, RAND Corporation, Santa Monica; Scarlett Lin Gomez, Cancer Prevention Institute of California, Fremont, CA; Michael S. Simon and Michele L. Cote, Karmanos Cancer Institute Detroit, MI; Giselle Corbie-Smith, University of North Carolina, Chapel Hill, NC; and Lucile L. Adams-Campbell, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC.
authors.forename: Ange
authors.initials: A
authors.lastname: Wang
authors.affiliation: Manali I. Patel, Ange Wang, Kristopher Kapphahn, Manisha Desai, Marcia L. Stefanick, and Heather A. Wakelee, Stanford University School of Medicine; Marcia L. Stefanick, Stanford Prevention Research Center; Heather A. Wakelee, Stanford Cancer Institute, Stanford; Rowan T. Chlebowski, Harbor-University of California, Los Angeles, Medical Center, Torrance; Chloe E. Bird, RAND Corporation, Santa Monica; Scarlett Lin Gomez, Cancer Prevention Institute of California, Fremont, CA; Michael S. Simon and Michele L. Cote, Karmanos Cancer Institute Detroit, MI; Giselle Corbie-Smith, University of North Carolina, Chapel Hill, NC; and Lucile L. Adams-Campbell, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC.
authors.forename: Kristopher
authors.initials: K
authors.lastname: Kapphahn
authors.affiliation: Manali I. Patel, Ange Wang, Kristopher Kapphahn, Manisha Desai, Marcia L. Stefanick, and Heather A. Wakelee, Stanford University School of Medicine; Marcia L. Stefanick, Stanford Prevention Research Center; Heather A. Wakelee, Stanford Cancer Institute, Stanford; Rowan T. Chlebowski, Harbor-University of California, Los Angeles, Medical Center, Torrance; Chloe E. Bird, RAND Corporation, Santa Monica; Scarlett Lin Gomez, Cancer Prevention Institute of California, Fremont, CA; Michael S. Simon and Michele L. Cote, Karmanos Cancer Institute Detroit, MI; Giselle Corbie-Smith, University of North Carolina, Chapel Hill, NC; and Lucile L. Adams-Campbell, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC.
authors.forename: Manisha
authors.initials: M
authors.lastname: Desai
authors.affiliation: Manali I. Patel, Ange Wang, Kristopher Kapphahn, Manisha Desai, Marcia L. Stefanick, and Heather A. Wakelee, Stanford University School of Medicine; Marcia L. Stefanick, Stanford Prevention Research Center; Heather A. Wakelee, Stanford Cancer Institute, Stanford; Rowan T. Chlebowski, Harbor-University of California, Los Angeles, Medical Center, Torrance; Chloe E. Bird, RAND Corporation, Santa Monica; Scarlett Lin Gomez, Cancer Prevention Institute of California, Fremont, CA; Michael S. Simon and Michele L. Cote, Karmanos Cancer Institute Detroit, MI; Giselle Corbie-Smith, University of North Carolina, Chapel Hill, NC; and Lucile L. Adams-Campbell, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC.
authors.forename: Rowan T
authors.initials: RT
authors.lastname: Chlebowski
authors.affiliation: Manali I. Patel, Ange Wang, Kristopher Kapphahn, Manisha Desai, Marcia L. Stefanick, and Heather A. Wakelee, Stanford University School of Medicine; Marcia L. Stefanick, Stanford Prevention Research Center; Heather A. Wakelee, Stanford Cancer Institute, Stanford; Rowan T. Chlebowski, Harbor-University of California, Los Angeles, Medical Center, Torrance; Chloe E. Bird, RAND Corporation, Santa Monica; Scarlett Lin Gomez, Cancer Prevention Institute of California, Fremont, CA; Michael S. Simon and Michele L. Cote, Karmanos Cancer Institute Detroit, MI; Giselle Corbie-Smith, University of North Carolina, Chapel Hill, NC; and Lucile L. Adams-Campbell, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Simon
authors.affiliation: Manali I. Patel, Ange Wang, Kristopher Kapphahn, Manisha Desai, Marcia L. Stefanick, and Heather A. Wakelee, Stanford University School of Medicine; Marcia L. Stefanick, Stanford Prevention Research Center; Heather A. Wakelee, Stanford Cancer Institute, Stanford; Rowan T. Chlebowski, Harbor-University of California, Los Angeles, Medical Center, Torrance; Chloe E. Bird, RAND Corporation, Santa Monica; Scarlett Lin Gomez, Cancer Prevention Institute of California, Fremont, CA; Michael S. Simon and Michele L. Cote, Karmanos Cancer Institute Detroit, MI; Giselle Corbie-Smith, University of North Carolina, Chapel Hill, NC; and Lucile L. Adams-Campbell, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC.
authors.forename: Chloe E
authors.initials: CE
authors.lastname: Bird
authors.affiliation: Manali I. Patel, Ange Wang, Kristopher Kapphahn, Manisha Desai, Marcia L. Stefanick, and Heather A. Wakelee, Stanford University School of Medicine; Marcia L. Stefanick, Stanford Prevention Research Center; Heather A. Wakelee, Stanford Cancer Institute, Stanford; Rowan T. Chlebowski, Harbor-University of California, Los Angeles, Medical Center, Torrance; Chloe E. Bird, RAND Corporation, Santa Monica; Scarlett Lin Gomez, Cancer Prevention Institute of California, Fremont, CA; Michael S. Simon and Michele L. Cote, Karmanos Cancer Institute Detroit, MI; Giselle Corbie-Smith, University of North Carolina, Chapel Hill, NC; and Lucile L. Adams-Campbell, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC.
authors.forename: Giselle
authors.initials: G
authors.lastname: Corbie-Smith
authors.affiliation: Manali I. Patel, Ange Wang, Kristopher Kapphahn, Manisha Desai, Marcia L. Stefanick, and Heather A. Wakelee, Stanford University School of Medicine; Marcia L. Stefanick, Stanford Prevention Research Center; Heather A. Wakelee, Stanford Cancer Institute, Stanford; Rowan T. Chlebowski, Harbor-University of California, Los Angeles, Medical Center, Torrance; Chloe E. Bird, RAND Corporation, Santa Monica; Scarlett Lin Gomez, Cancer Prevention Institute of California, Fremont, CA; Michael S. Simon and Michele L. Cote, Karmanos Cancer Institute Detroit, MI; Giselle Corbie-Smith, University of North Carolina, Chapel Hill, NC; and Lucile L. Adams-Campbell, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC.
authors.forename: Scarlett Lin
authors.initials: SL
authors.lastname: Gomez
authors.affiliation: Manali I. Patel, Ange Wang, Kristopher Kapphahn, Manisha Desai, Marcia L. Stefanick, and Heather A. Wakelee, Stanford University School of Medicine; Marcia L. Stefanick, Stanford Prevention Research Center; Heather A. Wakelee, Stanford Cancer Institute, Stanford; Rowan T. Chlebowski, Harbor-University of California, Los Angeles, Medical Center, Torrance; Chloe E. Bird, RAND Corporation, Santa Monica; Scarlett Lin Gomez, Cancer Prevention Institute of California, Fremont, CA; Michael S. Simon and Michele L. Cote, Karmanos Cancer Institute Detroit, MI; Giselle Corbie-Smith, University of North Carolina, Chapel Hill, NC; and Lucile L. Adams-Campbell, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC.
authors.forename: Lucile L
authors.initials: LL
authors.lastname: Adams-Campbell
authors.affiliation: Manali I. Patel, Ange Wang, Kristopher Kapphahn, Manisha Desai, Marcia L. Stefanick, and Heather A. Wakelee, Stanford University School of Medicine; Marcia L. Stefanick, Stanford Prevention Research Center; Heather A. Wakelee, Stanford Cancer Institute, Stanford; Rowan T. Chlebowski, Harbor-University of California, Los Angeles, Medical Center, Torrance; Chloe E. Bird, RAND Corporation, Santa Monica; Scarlett Lin Gomez, Cancer Prevention Institute of California, Fremont, CA; Michael S. Simon and Michele L. Cote, Karmanos Cancer Institute Detroit, MI; Giselle Corbie-Smith, University of North Carolina, Chapel Hill, NC; and Lucile L. Adams-Campbell, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC.
authors.forename: Michele L
authors.initials: ML
authors.lastname: Cote
authors.affiliation: Manali I. Patel, Ange Wang, Kristopher Kapphahn, Manisha Desai, Marcia L. Stefanick, and Heather A. Wakelee, Stanford University School of Medicine; Marcia L. Stefanick, Stanford Prevention Research Center; Heather A. Wakelee, Stanford Cancer Institute, Stanford; Rowan T. Chlebowski, Harbor-University of California, Los Angeles, Medical Center, Torrance; Chloe E. Bird, RAND Corporation, Santa Monica; Scarlett Lin Gomez, Cancer Prevention Institute of California, Fremont, CA; Michael S. Simon and Michele L. Cote, Karmanos Cancer Institute Detroit, MI; Giselle Corbie-Smith, University of North Carolina, Chapel Hill, NC; and Lucile L. Adams-Campbell, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC.
authors.forename: Marcia L
authors.initials: ML
authors.lastname: Stefanick
authors.affiliation: Manali I. Patel, Ange Wang, Kristopher Kapphahn, Manisha Desai, Marcia L. Stefanick, and Heather A. Wakelee, Stanford University School of Medicine; Marcia L. Stefanick, Stanford Prevention Research Center; Heather A. Wakelee, Stanford Cancer Institute, Stanford; Rowan T. Chlebowski, Harbor-University of California, Los Angeles, Medical Center, Torrance; Chloe E. Bird, RAND Corporation, Santa Monica; Scarlett Lin Gomez, Cancer Prevention Institute of California, Fremont, CA; Michael S. Simon and Michele L. Cote, Karmanos Cancer Institute Detroit, MI; Giselle Corbie-Smith, University of North Carolina, Chapel Hill, NC; and Lucile L. Adams-Campbell, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC.
authors.forename: Heather A
authors.initials: HA
authors.lastname: Wakelee
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008175:Lung Neoplasms / Q000201:enzymology* / Q000208:ethnology* / Q000401:mortality; D008875:Middle Aged; D017698:Postmenopause; D011446:Prospective Studies; D014481:United States / Q000453:epidemiology; D016387:Women's Health / Q000706:statistics & numerical data