title: Risk for Colorectal Adenomas Among Patients with Pancreatic Intraductal Papillary Mucinous Neoplasms: a Prospective Case-Control Study.
abstract: OBJECTIVE
  It has been reported that patients with intraductal papillary mucinous neoplasms of the pancreas are at an increased risk of colorectal cancer. The aim of our study was to investigate whether patients with intraductal papillary mucinous neoplasms are at a higher risk of colorectal adenomas with respect to the general population, as this condition represents the precursor of sporadic colorectal cancer.
  
  
  METHODS
  A case-control study was conducted at the Catholic University and University Sapienza, Rome, Italy. The cases were patients with intraductal papillary mucinous neoplasms without history of colorectal cancer, who had underwent screening colonoscopy for the first time. The controls were individuals who had underwent first time colonoscopy for screening or evaluation of non-specific abdominal symptoms. Chi-square and Fisher tests were used to compare the distributions of categorical variables.
  
  
  RESULTS
  We enrolled 122 cases and 246 controls. Colorectal polyps were found in 52 cases (42.6%) and 79 controls (32.1%) (p<0.05). In 29 cases (23.8%) and 57 controls (23.2%) histological examination disclosed adenomatous polyps (p=0.90). There was no difference between the groups in relation to the presence of polyps with low-grade (19.7% vs. 19.8%, p=0.98) and high-grade dysplasia (4.9% vs. 4.5%, p=0.85).
  
  
  CONCLUSIONS
  Patients with intraductal papillary mucinous neoplasms of the pancreas are not at an increased risk for the development of adenomatous colorectal polyps.
authors.affiliation: Digestive Endoscopy Unit;Institute of Public Health, Section of Hygiene, Catholic University; Rome, Italy.
authors.forename: Nikola
authors.initials: N
authors.lastname: Panic
authors.affiliation: Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome , Rome, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Capurso
authors.affiliation: Digestive Endoscopy Unit; Rome, Italy.
authors.forename: Fabia
authors.initials: F
authors.lastname: Attili
authors.affiliation: Digestive Endoscopy Unit; Rome, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Vitale
authors.affiliation: Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome , Rome, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Stigliano
authors.affiliation: Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome , Rome, Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Delle Fave
authors.affiliation: Institute of Public Health, Section of Hygiene, Catholic University; Rome, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Leoncini
authors.affiliation: Digestive Endoscopy Unit; Rome, Italy.
authors.forename: Milutin
authors.initials: M
authors.lastname: Bulajic
authors.affiliation: Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome , Rome, Italy.
authors.forename: Emilio
authors.initials: E
authors.lastname: Di Giulio
authors.affiliation: Digestive Endoscopy Unit; Rome, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Costamagna
authors.affiliation: Institute of Public Health, Section of Hygiene, Catholic University; Rome, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Boccia
authors.affiliation: Digestive Endoscopy Unit; Rome, Italy. albertolarghi@yahoo.it.
authors.forename: Alberto
authors.initials: A
authors.lastname: Larghi
mesh_terms: D018256:Adenomatous Polyps / Q000175:diagnosis / Q000453:epidemiology*; D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003111:Colonic Polyps / Q000175:diagnosis / Q000453:epidemiology*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000175:diagnosis / Q000453:epidemiology*; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012384:Rome / Q000453:epidemiology