title: FDG PET/CT allowing detection and follow-up of tumor cell transplantation.
abstract: After detection of small cell lung cancer in a 67-year-old patient who had donated a kidney 7 months earlier, the graft recipient underwent FDG-PET/CT to determine the presence/absence of tumor cell transmission. It showed abnormal increased uptake of the renal graft, associated with hypermetabolic lymph nodes and hepatic, pulmonary and bone lesions. Emergency graft resection was performed 5 days after PET/CT, permitting immunosuppressive therapy withdrawal. Pathologic examination of the kidney showed parenchymal infiltration by tumor cells compatible with small cell lung cancer. Thereafter, pathologists proved that the recipient's and donor's tumor cells matched using microsatellite markers. FDG-PET/CT was performed in the follow-up and showed progression in the donor despite chemotherapy and radiotherapy. He died a few months later. However, FDG-PET/CT showed a complete metabolic response after only 3 courses of chemotherapy in the recipient.
authors.affiliation: CHU of Lille, Department of Nuclear Medicine, Hôpital Claude Huriez, 2 Avenue Oscar Lambret, 59000, Lille, France. alice.jaillard@gmail.com.
authors.forename: Alice
authors.initials: A
authors.lastname: Jaillard
authors.affiliation: CHU of Lille, Department of Nuclear Medicine, Hôpital Claude Huriez, 2 Avenue Oscar Lambret, 59000, Lille, France.
authors.forename: Clio
authors.initials: C
authors.lastname: Baillet
authors.affiliation: CHU of Lille, Department of Nuclear Medicine, Hôpital Claude Huriez, 2 Avenue Oscar Lambret, 59000, Lille, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Béron
authors.affiliation: CHU of Lille, Department of Nephrology, Hôpital Claude Huriez, 2 Avenue Oscar Lambret, 59000, Lille, France.
authors.forename: Nahid
authors.initials: N
authors.lastname: Tabibzadeh
authors.affiliation: CHU of Lille, Department of Pulmonary and Thoracic Oncology, Hôpital Albert Calmette, 2 Avenue Oscar Lambret, 59000, Lille, France.|Université de Lille, Faculté de Médecine, Place de Verdun, 59000, Lille, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Scherpereel
authors.affiliation: CHU of Lille, Department of Nephrology, Hôpital Claude Huriez, 2 Avenue Oscar Lambret, 59000, Lille, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Frimat
authors.affiliation: CHU of Lille, Department of Anatomopathology, Hôpital Claude Huriez, 2 Avenue Oscar Lambret, 59000, Lille, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Perbet
authors.affiliation: CHU of Lille, Department of Anatomopathology, Hôpital Claude Huriez, 2 Avenue Oscar Lambret, 59000, Lille, France.
authors.forename: Vivianne
authors.initials: V
authors.lastname: Gnemmi
authors.affiliation: CHU of Lille, Department of Nephrology, Hôpital Claude Huriez, 2 Avenue Oscar Lambret, 59000, Lille, France.|Université de Lille, Faculté de Médecine, Place de Verdun, 59000, Lille, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Noël
authors.affiliation: CHU of Lille, Department of Nuclear Medicine, Hôpital Claude Huriez, 2 Avenue Oscar Lambret, 59000, Lille, France.|Université de Lille, Faculté de Médecine, Place de Verdun, 59000, Lille, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Huglo
mesh_terms: D017690:Cell Transplantation; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D055752:Small Cell Lung Carcinoma / Q000000981:diagnostic imaging* / Q000628:therapy*
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: 18F-FDG PET/CT; Donor cancer transmission; Renal transplantation; Small cell lung cancer