title: Drug the Bug!
abstract: Microbial metabolism of dietary components has been causally linked to cardiovascular disease and atherosclerosis. Now, Wang et al. demonstrate that inhibition of microbial TMA lyases, essential for production of pro-atherogenic trimethylamines, prevents atherosclerosis in vivo.
authors.affiliation: The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg SE-413 45, Sweden.
authors.forename: Annika Lindskog
authors.initials: AL
authors.lastname: Jonsson
authors.affiliation: The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg SE-413 45, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen 2200, Denmark. Electronic address: fredrik.backhed@wlab.gu.se.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Bäckhed
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy*; D002794:Choline / Q000031:analogs & derivatives*; D041981:Gastrointestinal Tract / Q000382:microbiology*; D000441:Hexanols / Q000008:administration & dosage*; D006801:Humans; D008190:Lyases / Q000037:antagonists & inhibitors*; D008744:Methylamines / Q000378:metabolism*
chemical_list: D000441:Hexanols; D008744:Methylamines; D008190:Lyases; D002794:Choline