title: Mussel-inspired soft-tissue adhesive based on poly(diol citrate) with catechol functionality.
abstract: Marine mussels tightly adhering to various underwater surfaces inspires human to design adhesives for wet tissue adhesion in surgeries. Characterization of mussel adhesive plaques describes a matrix of proteins containing 3,4-dihydroxyphenylalanine (DOPA), which provides strong adhesion in aquatic conditions. Several synthetic polymer systems have been developed based on this DOPA chemistry. Herein, a citrate-based tissue adhesives (POEC-d) was prepared by a facile one-pot melt polycondensation of two diols including 1,8-octanediol and poly(ethylene oxide) (PEO), citric acid (CA) and dopamine, and the effects of hydrophilic and soft PEO on the properties of adhesives were studied. It was found that the obtained adhesives exhibited water-soluble when the mole ratio of PEO to 1,8-octanediol was 70%, and the equilibrium swelling percentage of cured adhesive was about 144%, and degradation rate was in the range of 1-2 weeks. The cured adhesives demonstrated soft rubber-like behavior. The lap shear adhesion strength measured by bonding wet pig skin was in the range of 21.7-33.7 kPa, which was higher than that of commercial fibrin glue (9-15 kPa). The cytotoxicity tests showed the POEC-d adhesives had a low cytotoxicity. Our results supports that POEC-d adhesives, which combined strong wet adhesion with good biodegradability, acceptable swelling ratio, good elasticity and low cytotoxicity, have potentials in surgeries where surgical tissue adhesives, sealants, and hemostatic agents are used.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Material Science and Engineering, Donghua University, Shanghai, 201620, People's Republic of China. jiyali@dhu.edu.cn.
authors.forename: Yali
authors.initials: Y
authors.lastname: Ji
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Material Science and Engineering, Donghua University, Shanghai, 201620, People's Republic of China.
authors.forename: Ting
authors.initials: T
authors.lastname: Ji
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, People's Republic of China.
authors.forename: Kai
authors.initials: K
authors.lastname: Liang
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Material Science and Engineering, Donghua University, Shanghai, 201620, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry; D049872:Bivalvia / Q000737:chemistry*; D002396:Catechols / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002951:Citrates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D019343:Citric Acid / Q000737:chemistry*; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D008422:Materials Testing; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D033081:Shear Strength / Q000187:drug effects; D012867:Skin / Q000166:cytology / Q000187:drug effects; D013552:Swine; D014014:Tissue Adhesives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D002396:Catechols; D002951:Citrates; D011108:Polymers; D014014:Tissue Adhesives; D019343:Citric Acid; D011092:Polyethylene Glycols; C034221:catechol