title: A nitrous acid biosynthetic pathway for diazo group formation in bacteria.
abstract: Although some diazo compounds have bioactivities of medicinal interest, little is known about diazo group formation in nature. Here we describe an unprecedented nitrous acid biosynthetic pathway responsible for the formation of a diazo group in the biosynthesis of the ortho-diazoquinone secondary metabolite cremeomycin in Streptomyces cremeus. This finding provides important insights into the biosynthetic pathways not only for diazo compounds but also for other naturally occurring compounds containing nitrogen-nitrogen bonds.
authors.affiliation: Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sugai
authors.affiliation: Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Katsuyama
authors.affiliation: Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohnishi
mesh_terms: D001391:Azo Compounds / Q000737:chemistry; D001419:Bacteria / Q000378:metabolism*; D053898:Biosynthetic Pathways / Q000235:genetics*; D002853:Chromatography, Liquid; D003512:Cyclohexanones / Q000737:chemistry; D003979:Diazonium Compounds / Q000737:chemistry*; D005818:Genetic Engineering; D015394:Molecular Structure; D005810:Multigene Family / Q000235:genetics; D009608:Nitrous Acid / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D001391:Azo Compounds; D003512:Cyclohexanones; D003979:Diazonium Compounds; C094831:cremeomycin; D009608:Nitrous Acid