title: Optimization of chronic obstructive pulmonary disease treatment in clean-up workers of the Chornobyl NPP accident in the remote period after irradiation.
abstract: BACKGROUND
  According to the results of the clinical and epidemiological studies in clean-up workers of Chernobyl NPP accident in the remote period were detected the growth of morbidity of chronic obstructive pulmonary disease with substantial features of pathomorphosis, that make difficulties for treatment. The aim of the study was to determine the effectiveness of long-term administration (6 months) combination Аmbroxol (30 mg x 3 times per day) and Essenciale (600 mg x 2 times per day) added to basic treatment in patients with moderate to severe COPD - clean-up workers of the Chornobyl NPP accident.
  
  
  METHODS
  Studied 60 COPD patients before treatment and after 1 year from the beginning, who were randomly assigned to two groups: the first group of patients ( 32 persons ) additionally was appointed long reception (6 months) combination ambroxol (30 mg three times a day ) and Essenciale (600 mg twice daily ), in the second group (28 people) patients received only basic therapy. The doses of radiation exposure were 25 - 500 mSv. Were studied clinical, functional characteristics, the number of exacerbations.
  
  
  CONCLUSIONS
  Low response to the basic COPD therapy were shown by clean-up workers of the Chornobyl NPP accident, which is defined by the absence of significant changes in lung function tests. Additional appointments to the basic treatment of COPD ambroxol combination (30 mg 3 g / d) of Essenciale (600 mg 3 g / d) within 6 months of the liquidators of the Chernobyl possible to reduce the frequency of exacerbations in 46.9% patients without significant improvement in lung function tests.
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykova str., 53, Kyiv, 04050, Ukraine.
authors.forename: V O
authors.initials: VO
authors.lastname: Sushko
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykova str., 53, Kyiv, 04050, Ukraine.
authors.forename: L I
authors.initials: LI
authors.lastname: Shvaiko
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykova str., 53, Kyiv, 04050, Ukraine.
authors.forename: K D
authors.initials: KD
authors.lastname: Bazyka
authors.affiliation: State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykova str., 53, Kyiv, 04050, Ukraine.
authors.forename: A S
authors.initials: AS
authors.lastname: Riazhska
keywords: Chernobyl NPP accident; chronic obstructive pulmonary disease; ionizing radiation; lung function tests; treatment