title: Significant impact of transperineal template biopsy of the prostate at a single tertiary institution.
abstract: OBJECTIVE
  The objective was to review the impact of transperineal biopsy (TPB) at our institution by assessing rates of cancer detection/grading, treatment outcomes and complications.
  
  
  METHODS
  A retrospective review of TPBs between 2009 and 2013 was performed. Variables included reason for TPB, age, prostate-specific antigen, previous histology, TPB histology, and management outcomes.
  
  
  RESULTS
  In total, 110 patients underwent 111 TPBs at our institution. On average, 22 cores were taken from each procedure. Disease-upgrade occurred in 37.5% of active surveillance patients, 35% of patients with previous negative transrectal ultrasound, and 58.8% in patients undergoing TPB for other reasons. Of these patients, anterior and/or transition zones were involved in 66%, 79%, and 80%, respectively. Involvement in anterior and/or transition zones only occurred in 40%, 37%, and 10%, respectively. About 77% of patients with disease-upgrading underwent treatment with curative intent. Complications included a 6.3% rate of acute urinary retention and 2.7% of clot retention, with no episodes of urosepsis.
  
  
  CONCLUSIONS
  Transperineal biopsy at our institution showed a high rate of disease-upgrading, with a large proportion involving anterior and transition zones. A significant amount of patients went on to receive curative treatment. TPB is a valuable diagnostic procedure with minimal risk of developing urosepsis. We believe TBP should be offered as an option for all repeat prostate biopsies and considered as an option for initial prostate biopsy.
authors.affiliation: Department of Urology, Alfred Health, Melbourne, Australia.
authors.forename: Sean
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Urology, Alfred Health, Melbourne, Australia.
authors.forename: Fairleigh
authors.initials: F
authors.lastname: Reeves
authors.affiliation: Department of Urology, Alfred Health, Melbourne, Australia.
authors.forename: Jessica
authors.initials: J
authors.lastname: Preece
authors.affiliation: Department of Urology, Alfred Health, Melbourne, Australia.
authors.forename: Prassannah
authors.initials: P
authors.lastname: Satasivam
authors.affiliation: Department of Urology, Alfred Health, Melbourne, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Royce
authors.affiliation: Department of Urology, Alfred Health, Melbourne, Australia.
authors.forename: Jeremy P
authors.initials: JP
authors.lastname: Grummet
keywords: Biopsy; complications; prostate; prostatic neoplasms; sepsis; transperineal