title: Leucocontextins A-R, lanostane-type triterpenoids from Ganoderma leucocontextum.
abstract: Eighteen new lanostane-type triterpenoids, namely leucocontextins A-R (1-18) were isolated from the fruiting bodies of Ganoderma leucocontextum. Their structures were established by 1D and 2D NMR data in conjunction with HRESIMS/HREIMS, X-ray single crystal diffraction analysis. Compound 18 exhibited weak cytotoxicity against K562 and MCF-7 cell lines with IC50 of 20-30 μM.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Zhen-Zhu
authors.initials: ZZ
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: He-Ping
authors.initials: HP
authors.lastname: Chen
authors.affiliation: School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Li
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Ze-Jun
authors.initials: ZJ
authors.lastname: Dong
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Bai
authors.affiliation: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China.
authors.forename: Zhong-Yu
authors.initials: ZY
authors.lastname: Zhou
authors.affiliation: School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. Electronic address: tfeng@mail.scuec.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. Electronic address: jkliu@mail.kib.ac.cn.
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D032902:Ganoderma / Q000737:chemistry*; D006801:Humans; D020014:K562 Cells; D061986:MCF-7 Cells; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D014315:Triterpenes; C000608982:leucocontextin R
keywords: Cytotoxicity; Ganoderma leucocontextum; Triterpenoids