title: Ultrananocrystalline Diamond Integration with Pyrolytic Carbon Components of Mechanical Heart Valves.
abstract: In this report, an idea of integrating ultrananocrystalline diamond (UNCD) with pyrolytic carbon (PyC) -based mechanical heart valves, has been demonstrated. The report addresses the strategies to avoid graphitization and film delamination during the diamond coating. Raman and scratch tests showed that a UNCD film with high purity could adhere to the PyC substrate strongly. A thrombin generation study demonstrated an excellent biocompatibility of UNCD towards fresh human platelets. These results suggest that UNCD could be a good candidate of surface material for next generation heart valves and other implantable devices.
authors.affiliation: Advanced Diamond Technologies, Inc. 48 E Belmont Drive, Romeoville, IL 60446, USA.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Zeng
authors.affiliation: Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794.
authors.forename: Wei
authors.initials: W
authors.lastname: Yin
authors.affiliation: Advanced Diamond Technologies, Inc. 48 E Belmont Drive, Romeoville, IL 60446, USA.
authors.forename: Grace
authors.initials: G
authors.lastname: Catausan
authors.affiliation: Advanced Diamond Technologies, Inc. 48 E Belmont Drive, Romeoville, IL 60446, USA.
authors.forename: Nicolaie
authors.initials: N
authors.lastname: Moldovan
authors.affiliation: Advanced Diamond Technologies, Inc. 48 E Belmont Drive, Romeoville, IL 60446, USA.
authors.forename: John
authors.initials: J
authors.lastname: Carlisle
keywords: Ultrananocrystalline diamond (UNCD); biocompatibility; implantable devices; mechanical heart valve; pyrolytic carbon