title: In vivo evaluation of the effects of hydraulic calcium silicate dental cements on plasma and liver aluminium levels in rats.
abstract: Our aim was to test whether the presence of three hydraulic calcium silicate dental cements--MTA Angelus, MTA Fillapex, and Theracal LC--in the dental extraction socket of an in vivo model, would affect the levels of aluminium (Al) in the plasma and liver. Following anesthesia, the right upper incisor of each male Wistar albino rat was extracted and polyethylene tubes filled with MTA Angelus, MTA Fillapex, or Theracal LC were inserted into the depth of the extraction socket and gingival tissue was sutured. The rats were killed 7, 30, or 60 d after the operation. Blood and liver samples were obtained from the rats before they were killed, and the levels of Al were measured by atomic absorption spectrometry. Plasma Al levels were higher in the rats in which the mineral trioxide aggregate (MTA) cements were implanted, especially MTA Angelus and MTA Fillapex, compared with control rats. In liver samples, however, the differences in Al level were not statistically significant. Our results show that Al might have been released into the circulation from the three dental cements tested, especially MTA Angelus and MTA Fillapex. Further research should be carried out on the possible biological effects of Al liberated from dental cements.
authors.affiliation: Department of Restorative Dentistry and Endodontics, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Kadriye
authors.initials: K
authors.lastname: Demirkaya
authors.affiliation: Department of Biomedical Engineering, TOBB University of Economics and Technology, Ankara, Turkey.
authors.forename: Birsen
authors.initials: B
authors.lastname: Can Demirdöğen
authors.affiliation: Department of Restorative Dentistry and Endodontics, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Öncel Torun
authors.affiliation: Department of Toxicology, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Erdem
authors.affiliation: Department of Toxicology, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Çetinkaya
authors.affiliation: Department of Toxicology, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Cemal
authors.initials: C
authors.lastname: Akay
mesh_terms: D000535:Aluminum / Q000097:blood*; D017607:Aluminum Compounds; D000818:Animals; D002118:Calcium; D003738:Dental Cements; D004338:Drug Combinations; D008099:Liver; D008297:Male; D008422:Materials Testing; D010087:Oxides; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials; D017640:Silicates
chemical_list: D017607:Aluminum Compounds; D003738:Dental Cements; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; D000535:Aluminum; D002118:Calcium
keywords: MTA Angelus; MTA Fillapex; Theracal LC; endodontics; mineral trioxide aggregate