title: Implications of Fibroblast growth factor/Klotho system in glucose metabolism and diabetes.
abstract: Diabetes mellitus, especially type 2 diabetes, remains the dominant metabolic disease worldwide, with an expected increase in prevalence of over 50% in the next 20 years. Our knowledge about the pathophysiology of type 2 diabetes continues to be incomplete, with unmet medical need for new therapies. The characterization of the fibroblast growth factor (FGF) family and the discovery of endocrine FGFs provided new information on the mechanisms of regulation and homeostasis of carbohydrate metabolism. More specifically, FGF19 and FGF21 signaling pathways have been linked to different glucose metabolic processes, including hepatic glucose synthesis, glycogen synthesis, glucose uptake, and insulin sensitivity, among others, and these molecules have been further related to the pathophysiology of diabetes mellitus. In-depth comprehension of these growth factors may bring to light new potential therapeutic targets for the treatment of diabetes mellitus.
authors.affiliation: Research Unit, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Donate-Correa
authors.affiliation: Research Unit, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Martín-Núñez
authors.affiliation: Clinical Analysis Service, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
authors.forename: Nayra Pérez
authors.initials: NP
authors.lastname: Delgado
authors.affiliation: Clinical Analysis Service, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
authors.forename: Mercedes Muros
authors.initials: MM
authors.lastname: de Fuentes
authors.affiliation: IIS-Fundacion Jiménez Díaz, School of Medicine, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo-IRSIN and REDinREN, Madrid, Spain; Department of Nephrology, Fundación Jiménez Díaz, Madrid, Spain.
authors.forename: Alberto Ortiz
authors.initials: AO
authors.lastname: Arduan
authors.affiliation: Research Unit, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Mora-Fernández
authors.affiliation: Research Unit, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain; Nephrology Service, University Hospital Nuestra Señora de Candelaria, REDinREN, Santa Cruz de Tenerife, Spain. Electronic address: jnavgon@gobiernodecanarias.org.
authors.forename: Juan F
authors.initials: JF
authors.lastname: Navarro González
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D000090265:Klotho Proteins; D008099:Liver / Q000378:metabolism; D015398:Signal Transduction
chemical_list: C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D005966:Glucuronidase; D000090265:Klotho Proteins; D005947:Glucose
keywords: Diabetes; Fibroblast growth factors; Glucose metabolism; Klotho