title: The steroid metabolome in men with mood and anxiety disorders.
abstract: The mood and behavior of individuals result from an orchestra of many factors. Among them steroids play an important role; however, only several common hormones have been investigated in this respect. It has been demonstrated that some steroid metabolites long considered merely the products of steroid hormone metabolism in fact possess considerable activity in the CNS. For this reason we studied the steroid metabolome including 50 analytes in 20 men with depression, 20 men with anxiety and 30 healthy controls. Significant differences were found not only between controls and men with either depression or anxiety, but also between men with depression and anxiety. Particularly striking were those steroids until now not generally associated with depression or anxiety, namely conjugated steroid forms, especially sulfates.
authors.affiliation: Institute of Endocrinology, Prague, Czech Republic. mduskova@endo.cz.
authors.forename: M
authors.initials: M
authors.lastname: Dušková
authors.forename: M
authors.initials: M
authors.lastname: Hill
authors.forename: M
authors.initials: M
authors.lastname: Bičíková
authors.forename: M
authors.initials: M
authors.lastname: Šrámková
authors.forename: D
authors.initials: D
authors.lastname: Řípová
authors.forename: P
authors.initials: P
authors.lastname: Mohr
authors.forename: L
authors.initials: L
authors.lastname: Stárka
mesh_terms: D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D055442:Metabolome / Q000502:physiology*; D008875:Middle Aged; D019964:Mood Disorders / Q000097:blood* / Q000175:diagnosis*; D018377:Neurotransmitter Agents / Q000097:blood*; D055815:Young Adult
chemical_list: D018377:Neurotransmitter Agents