title: Griseofulvin and/or Terbinafine Induced Toxic Epidermal Necrolysis in an Adult Female Patient - A Case Report.
abstract: An 18 years old female patient, who was taking treatment for tinea cruris developed Toxic Epidermal Necrolysis (TEN) due to therapeutic dose of griseofulvin with concomitant use of terbinafine. Both the drugs were stopped; patient's condition was gradually improved after starting the treatment. As per WHO-UMC causality assessment criteria, association between reaction and drug was possible (for both griseofulvin and terbinafine). Griseofulvin and terbinafine, both are widely used as an oral antifungal agent to treat fungal infections, careful monitoring is required in the initial periods of the treatment to prevent such type of serious adverse drug reaction. We report a case of TEN possibly caused by griseofulvin with concomitant use of terbinafine resulting in diagnostic difficulty.
authors.affiliation: Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001, Gujarat, India. dharamvir.jadeja@yahoo.com.
authors.forename: Dharamvirsinh
authors.initials: D
authors.lastname: Jadeja
authors.forename: Chandra S
authors.initials: CS
authors.lastname: Jaiswal
authors.forename: Ashwin
authors.initials: A
authors.lastname: Panchasra
authors.forename: Chandrabhanu B
authors.initials: CB
authors.lastname: Tripathi
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D006118:Griseofulvin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D009281:Naphthalenes / Q000008:administration & dosage / Q000009:adverse effects*; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D000077291:Terbinafine
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D006118:Griseofulvin; D003907:Dexamethasone; D000077291:Terbinafine