title: Comparison of Naftopidil 75 mg with Tamsulosin Hydrochloride 0.2 mg in the Treatment of Lower Urinary Tract Symptoms with Benign Prostatic Hyperplasia.
abstract: OBJECTIVE
  To compare the efficacy of two α1 -adrenoceptor antagonists, α1D -adrenoceptor-selective naftopidil (Naf) 75 mg and α1A -adrenoceptor-selective tamsulosin hydrochloride (Tam) 0.2 mg, for the treatment of lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH).
  
  
  METHODS
  Seventy-seven patients with LUTS secondary to BPH were enrolled. Data were gathered from patients retrospectively: 41 patients who were prescribed Naf 75 mg for 4 weeks and 36 patients who were prescribed Tam 0.2 mg for 4 weeks, respectively. The efficacy criteria were improvement in LUTS International Prostate Symptom Score (IPSS) and quality of life (QOL) scores after dosing.
  
  
  RESULTS
  Naf 75 mg significantly improved symptoms in all 11 categories (overall IPSS, incomplete emptying, voiding symptoms [Intermittency, poor flow and straining], storage symptoms [daytime frequency, urgency and nocturia frequency], QOL index, intermittency, poor flow, straining, daytime frequency, urgency, and nocturia frequency) (P < 0.05). Tam 0.2 mg significantly suppressed 10 of the 11 tested symptom categories except straining (P < 0.05). Comparison data of the two drugs tended to show Naf 75 mg had better efficacy on nocturia frequency than Tam 0.2 mg (P < 0.05).
  
  
  CONCLUSIONS
  Naf 75 mg might show a better efficacy for LUTS with BPH in nocturia frequency than Tam 0.2 mg.
authors.affiliation: Department of Urology, Shinko Hospital, Kobe, JapanDivision of Urology, Department of Organs Therapeutics, Kobe University Graduate School of Medicine, Kobe, JapanDepartment of Urology, Akashi Municipal Hospital, Kobe, Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shigemura
authors.affiliation: Department of Urology, Shinko Hospital, Kobe, JapanDivision of Urology, Department of Organs Therapeutics, Kobe University Graduate School of Medicine, Kobe, JapanDepartment of Urology, Akashi Municipal Hospital, Kobe, Japan.
authors.forename: Fukashi
authors.initials: F
authors.lastname: Yamamichi
authors.affiliation: Department of Urology, Shinko Hospital, Kobe, JapanDivision of Urology, Department of Organs Therapeutics, Kobe University Graduate School of Medicine, Kobe, JapanDepartment of Urology, Akashi Municipal Hospital, Kobe, Japan.
authors.forename: Minori
authors.initials: M
authors.lastname: Matsumoto
authors.affiliation: Department of Urology, Shinko Hospital, Kobe, JapanDivision of Urology, Department of Organs Therapeutics, Kobe University Graduate School of Medicine, Kobe, JapanDepartment of Urology, Akashi Municipal Hospital, Kobe, Japan.
authors.forename: Kazushi
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Department of Urology, Shinko Hospital, Kobe, JapanDivision of Urology, Department of Organs Therapeutics, Kobe University Graduate School of Medicine, Kobe, JapanDepartment of Urology, Akashi Municipal Hospital, Kobe, Japan.
authors.forename: Masuo
authors.initials: M
authors.lastname: Yamashita
authors.affiliation: Department of Urology, Shinko Hospital, Kobe, JapanDivision of Urology, Department of Organs Therapeutics, Kobe University Graduate School of Medicine, Kobe, JapanDepartment of Urology, Akashi Municipal Hospital, Kobe, Japan.
authors.forename: Soichi
authors.initials: S
authors.lastname: Arakawa
authors.affiliation: Department of Urology, Shinko Hospital, Kobe, JapanDivision of Urology, Department of Organs Therapeutics, Kobe University Graduate School of Medicine, Kobe, JapanDepartment of Urology, Akashi Municipal Hospital, Kobe, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Fujisawa
keywords: benign prostatic hyperplasia; lower urinary tract symptoms; naftopidil 75 mg; nocturia frequency; symptom scores