title: Immunometabolism governs dendritic cell and macrophage function.
abstract: Recent studies on intracellular metabolism in dendritic cells (DCs) and macrophages provide new insights on the functioning of these critical controllers of innate and adaptive immunity. Both cell types undergo profound metabolic reprogramming in response to environmental cues, such as hypoxia or nutrient alterations, but importantly also in response to danger signals and cytokines. Metabolites such as succinate and citrate have a direct impact on the functioning of macrophages. Immunogenicity and tolerogenicity of DCs is also determined by anabolic and catabolic processes, respectively. These findings provide new prospects for therapeutic manipulation in inflammatory diseases and cancer.
authors.affiliation: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland laoneill@tcd.ie pearceed@ie-freiburg.mpg.de.
authors.forename: Luke A J
authors.initials: LA
authors.lastname: O'Neill
authors.affiliation: Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany laoneill@tcd.ie pearceed@ie-freiburg.mpg.de.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Pearce
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism*; D004734:Energy Metabolism; D005110:Extracellular Space / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006019:Glycolysis; D006031:Glycosylation; D006801:Humans; D007113:Immunity, Innate; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism*; D053858:Metabolic Networks and Pathways; D009569:Nitric Oxide / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D015398:Signal Transduction; D000097983:ERRalpha Estrogen-Related Receptor
chemical_list: D005227:Fatty Acids; D009569:Nitric Oxide; D011453:Prostaglandins; D017382:Reactive Oxygen Species; D011960:Receptors, Estrogen; D000097983:ERRalpha Estrogen-Related Receptor