title: Epithelial Plasticity versus EMT in Kidney Fibrosis.
abstract: Ten percent of the population worldwide suffers from chronic kidney disease (CKD), characterized by fibrotic changes in the kidney. Fibrosis is associated with loss of epithelial parenchyma, and accumulation of myofibroblasts, fibrillary collagen, and inflammatory cells. Two recent papers highlight the critical role of Twist and Snai1 transcription factors in kidney fibrosis.
authors.affiliation: Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Shizheng
authors.initials: S
authors.lastname: Huang
authors.affiliation: Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: ksusztak@mail.med.upenn.edu.
authors.forename: Katalin
authors.initials: K
authors.lastname: Susztak
mesh_terms: D000818:Animals; D059447:Cell Cycle Checkpoints; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008297:Male; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D014157:Transcription Factors