title: Dosimetry at the sub-cellular scale of Auger-electron emitter 99mTc in a mouse single thyroid follicle.
abstract: The Auger-electrons emitted by (99m)Tc have been recently associated with the induction of thyroid stunning in in vivo experiments in mice, making the dosimetry at the sub-cellular level of (99m)Tc a pertinent and pressing subject. The S-values for (99m)Tc were calculated using MCNP6, which was first validated for studies at the sub-cellular scale and for low energies electrons. The calculation was then performed for (99m)Tc within different cellular compartments in a single mouse thyroid follicle model, considering the radiative and non-radiative transitions of the (99m)Tc radiation spectrum. It was shown that the contribution of the (99m)Tc Auger and low energy electrons to the absorbed dose to the follicular cells' nucleus is important, being at least of the same order of magnitude compared to the emitted photons' contribution and cannot be neglected. The results suggest that Auger-electrons emitted by (99m)Tc play a significant role in the occurrence of the thyroid stunning effect in mice.
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM/SDI/LEDI, BP-17, 31, Avenue de la Division Leclerc, 92262 Fontenay-aux-Roses, France. Electronic address: ana.taborda@irsn.fr.
authors.forename: A
authors.initials: A
authors.lastname: Taborda
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM/SDI/LEDI, BP-17, 31, Avenue de la Division Leclerc, 92262 Fontenay-aux-Roses, France.
authors.forename: N
authors.initials: N
authors.lastname: Benabdallah
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM/SDI/LEDI, BP-17, 31, Avenue de la Division Leclerc, 92262 Fontenay-aux-Roses, France.
authors.forename: A
authors.initials: A
authors.lastname: Desbrée
mesh_terms: D065638:Absorption, Radiation / Q000502:physiology; D000818:Animals; D003198:Computer Simulation; D004583:Electrons; D051379:Mice; D008954:Models, Biological; D015233:Models, Statistical; D009010:Monte Carlo Method; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D013347:Subcellular Fractions / Q000502:physiology*; D013667:Technetium / Q000032:analysis*; D013961:Thyroid Gland / Q000502:physiology* / Q000648:ultrastructure
chemical_list: D013667:Technetium
keywords: Auger-electrons; Dosimetry; Monte Carlo; Mouse thyroid; Sub-cellular scale