title: No Association between Catalase Gene Polymorphism and Gastric Carcinoma and Hepatocellular Carcinoma in Koreans.
abstract: OBJECTIVE
  Oxidative stress has been implicated in the pathogenesis of various diseases. Catalase is one of the main defense mechanisms against oxidative stress. To examine the possible relationship between oxidative stress, and gastric and hepatocellular carcinomas, HinfI restriction length polymorphism (RFLP) in the human catalase gene was assessed.
  
  
  METHODS
  The genotype and allele frequencies in the promoter region of the catalase gene were studied by PCR-RFLP in 108 Korean controls, 80 Korean gastric carcinoma (GC) and 106 Korean hepatocellular carcinoma (HCC) patients.
  
  
  RESULTS
  No statistically significant differences were found in the genotypic distribution and allelic frequencies between the controls and both types of carcinoma patient.
  
  
  CONCLUSIONS
  To address the possible contribution of oxidative stresses to the pathogenesis of gastric and hepatocellular carcinomas, the associations between the catalase gene polymorphism and GC and HCC susceptibilities were studied. As a result, the catalase gene polymorphism was found not to be determinant of GC and HCC susceptibilities. Further studies are required on various other oxidative stress related genes to elucidate the mechanisms of GC and HCC.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Ran Young
authors.initials: RY
authors.lastname: Park
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Lee
authors.forename: Euh Jun
authors.initials: EJ
authors.lastname: Jeoung
authors.forename: Su Youn
authors.initials: SY
authors.lastname: Nam
authors.forename: Jae Gun
authors.initials: JG
authors.lastname: Lee
authors.forename: Kye Young
authors.initials: KY
authors.lastname: Han
authors.forename: Hee Jae
authors.initials: HJ
authors.lastname: Lee
authors.forename: Joo Ho
authors.initials: JH
authors.lastname: Chung
authors.forename: Yun Gul
authors.initials: YG
authors.lastname: Ahn
authors.forename: Sung Vin
authors.initials: SV
authors.lastname: Yim
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Cho
authors.forename: Yeon Hee
authors.initials: YH
authors.lastname: Park
keywords: Catalase; Gastric carcinoma; Hepatocellular carcinoma; Oxidative stress; PCR-RFLP; Polymorphism