title: Modulatory Effects of Ferulic Acid on Cadmium-Induced Brain Damage.
abstract: Studies have shown the pharmacological relevance of phenolics like ferulic acid (FA) in promoting health. This study sought to investigate the modulatory effects of FA on cadmium-induced brain damage in rats. Brain damage was induced in Wistar strain rats by oral administration of cadmium (5 mg/kg body weight) for 21 days. Assays for malondialdehyde (MDA) content, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO), and Na(+)/K(+)-ATPase activities were carried out. The study revealed significant (P < .05) increases in the MDA content and all enzymes' (AChE, BChE, MAO, and Na(+)/K(+)-ATPase) activity investigated following cadmium administration. However, rats administered FA (10 and 20 mg/kg body weight) alongside cadmium significantly (P < .05) protected the brain by reversing the level of lipid peroxidation as measured by the MDA content as well as the enzymes' activity. This study, therefore, substantiates the neuroprotective potentials of FA especially in the management of cadmium-induced toxicity.
authors.affiliation: Federal University of Technology, Akure, Ondo State, Nigeria.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Adefegha
authors.affiliation: Federal University of Technology, Akure, Ondo State, Nigeria.
authors.forename: Olasunkanmi S
authors.initials: OS
authors.lastname: Omojokun
authors.affiliation: Federal University of Technology, Akure, Ondo State, Nigeria goboh2001@yahoo.com.
authors.forename: Ganiyu
authors.initials: G
authors.lastname: Oboh
authors.affiliation: Federal University of Technology, Akure, Ondo State, Nigeria.
authors.forename: Olasunkanmi
authors.initials: O
authors.lastname: Fasakin
authors.affiliation: Federal University of Technology, Akure, Ondo State, Nigeria.
authors.forename: Opeyemi
authors.initials: O
authors.lastname: Ogunsuyi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects; D001930:Brain Injuries / Q000139:chemically induced* / Q000378:metabolism; D002104:Cadmium / Q000633:toxicity*; D003373:Coumaric Acids / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D003373:Coumaric Acids; D002104:Cadmium; C004999:ferulic acid
keywords: Na+/K+-ATPase; cadmium; cholinesterases; ferulic acid; malondialdehyde; monoamine oxidase