title: Infected bone inactivation combined with transplantation of autologous platelet-rich plasma and bone marrow for treatment of chronic osteomyelitis.
abstract: OBJECTIVE
  Here we tested the therapeutic efficacy of infected bone inactivation combined with transplantation of autologous platelet-rich plasma and bone marrow in chronic osteomyelitis.
  
  
  METHODS
  64 patients with chronic osteomyelitis were randomly divided into two groups. Patients in control group received conventional antibiotic and surgical treatments, while patients in the experimental treatment group underwent infected bone inactivation combined with transplantation of autologous platelet-rich plasma and bone marrow. The X-ray, histological, and biochemical (alkaline phosphatase) changes were assessed at 4, 8, 12 and 16 weeks after the treatment.
  
  
  RESULTS
  At all tested study points, X-ray and histological scores, and alkaline phosphatase levels were significantly better in patients of the experimental treatment group.
  
  
  CONCLUSIONS
  Infected bone inactivation combined with transplantation of autologous platelet-rich plasma and bone marrow achieves beneficial therapeutic results in chronic osteomyelitis.
authors.affiliation: Departments of Foot and Ankle Surgery and 2Departments of Surgery; Xi'an Hong Hui Hospital, Xi'an, China. drsunxiaoke@163.com.
authors.forename: J-H
authors.initials: JH
authors.lastname: Wang
authors.forename: K
authors.initials: K
authors.lastname: Zhao
authors.forename: H-L
authors.initials: HL
authors.lastname: Liu
authors.forename: H-M
authors.initials: HM
authors.lastname: Zhao
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: X-K
authors.initials: XK
authors.lastname: Sun
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000379:methods*; D001861:Bone Regeneration / Q000502:physiology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000175:diagnosis* / Q000628:therapy*; D053657:Platelet-Rich Plasma / Q000502:physiology; D014182:Transplantation, Autologous / Q000379:methods; D016896:Treatment Outcome