title: Differentially expressed microRNAs in colorectal cancer metastasis.
abstract: Tumor metastasis continues to be the most significant contributor to cancer related mortality, and although several studies have examined expression profiles emanating from patients with metastatic disease, very little information is available about signatures that differentiate metastatic lesions from primary tumors and associated normal tissues, largely because such matched tissue sample series are rare. This study was specifically designed to identify the metastasis relevant microRNAs in colorectal cancer and characterize microRNAs that modulate the metastatic phenotype. Here we describe in detail how the data, deposited in the Gene Expression Omnibus (GEO) with the accession number GSE54088, was generated including the basic analysis as contained in the manuscript published in Cancer Research with the PMID 26069251.
authors.affiliation: Department of Experimental Surgery, Medical Faculty Mannheim, University of Heidelberg, Germany ; Centre for Biomedicine and Medical Technology (CBTM), Mannheim, Germany.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Abba
authors.affiliation: Department of Biostatistics, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Benner
authors.affiliation: Department of Experimental Surgery, Medical Faculty Mannheim, University of Heidelberg, Germany ; Centre for Biomedicine and Medical Technology (CBTM), Mannheim, Germany.
authors.forename: Nitin
authors.initials: N
authors.lastname: Patil
authors.affiliation: Genomics and Proteomics Core Facility, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Heil
authors.affiliation: Department of Experimental Surgery, Medical Faculty Mannheim, University of Heidelberg, Germany ; Centre for Biomedicine and Medical Technology (CBTM), Mannheim, Germany.
authors.forename: Heike
authors.initials: H
authors.lastname: Allgayer
keywords: Colorectal cancer; Illumina microRNA array; Metastasis; MicroRNAs