title: Cell-to-Cell Transcript Variability: Seeing Signal in the Noise.
abstract: How stochastic is gene expression in mammalian cells? Not very, according to Battich et al., who report that single-cell variability in cytoplasmic mRNAs is remarkably predictable given measurements of a cell's phenotypic state and microenvironment. The noise from transcriptional bursts is buffered by a hallmark of eukaryotes-the nucleus.
authors.affiliation: Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: kjanes@virginia.edu.
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Janes
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D006801:Humans