title: Prognostic significance of CD44V6 expression in osteosarcoma: a meta-analysis.
abstract: Numerous individual studies evaluating the relationship between CD44V6 over-expression and prognostic impact in patients with osteosarcoma (OS) have yielded in conclusive results. This meta-analysis aimed to determine the value of cell adhesion molecule CD44V6 in prognosis of OS by conducting a systematic review and meta-analysis. A comprehensive search was conducted using PubMed (medline), Embase, ISI Web of Knowledge, Springer, the Cochrane Library, Scopus, BioMed Central, ScienceDirect, Wanfang, Weipu, and China National Knowledge Internet (CNKI) databases from inception through May 26, 2015. All available articles written in English or Chinese that investigated the expression of CD44V6 and the prognosis of OS were included. The quantity of the studies was evaluated according to the critical review checklist of the Dutch Cochrane Centre proposed by MOOSE. Finally, a total of eight studies with 486 OS patients were involved and the results indicated that the positive expression of CD44V6 predicts neoplasm metastasis (RR = 1.76, 95 % CI 1.38-2.25, p < 0.00001), and poor survival in OS with the pooled HR of 1.53 (95 % CI 1.25-1.88, p < 0.0001). No significant heterogeneity was observed among all studies. In conclusion, the present meta-analysis and systematic review strongly suggest that CD44V6 over-expression is associated with overall survival rate and metastasis in OS, and may be used as a prognostic biomarker to guide the clinical therapy for OS.
authors.affiliation: Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China. hellozyycool@163.com.
authors.forename: Yunyuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics, Qingdao Municipal Hospital, Qingdao, 266071, China.
authors.forename: Chunming
authors.initials: C
authors.lastname: Ding
authors.affiliation: College of Laboratory Medicine, Key Laboratory of Laboratory Medical Diagnostics designated by Chinese Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.|Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, IL, 60637, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
authors.forename: Guirong
authors.initials: G
authors.lastname: Sun
authors.affiliation: Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
authors.forename: Yongxian
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
authors.forename: Longqiang
authors.initials: L
authors.lastname: Xu
authors.affiliation: College of Laboratory Medicine, Key Laboratory of Laboratory Medical Diagnostics designated by Chinese Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China. cxkakicoco2014@163.com.
authors.forename: Xian
authors.initials: X
authors.lastname: Chen
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis* / Q000235:genetics; D012516:Osteosarcoma / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality; D011379:Prognosis; D015996:Survival Rate / Q000639:trends
chemical_list: D014408:Biomarkers, Tumor; C112697:CD44v6 antigen; D018960:Hyaluronan Receptors