title: Prefrontal-Hippocampal Interactions in Memory and Emotion.
abstract: The hippocampal formation (HPC) and medial prefrontal cortex (mPFC) have well-established roles in memory encoding and retrieval. However, the mechanisms underlying interactions between the HPC and mPFC in achieving these functions is not fully understood. Considerable research supports the idea that a direct pathway from the HPC and subiculum to the mPFC is critically involved in cognitive and emotional regulation of mnemonic processes. More recently, evidence has emerged that an indirect pathway from the HPC to the mPFC via midline thalamic nucleus reuniens (RE) may plays a role in spatial and emotional memory processing. Here we will consider how bidirectional interactions between the HPC and mPFC are involved in working memory, episodic memory and emotional memory in animals and humans. We will also consider how dysfunction in bidirectional HPC-mPFC pathways contributes to psychiatric disorders.
authors.affiliation: Department of Psychology and Institute for Neuroscience, Texas A&M University College Station, TX, USA.
authors.forename: Jingji
authors.initials: J
authors.lastname: Jin
authors.affiliation: Department of Psychology and Institute for Neuroscience, Texas A&M University College Station, TX, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Maren
keywords: PTSD; context; emotion; extinction; memory; prefrontal cortex; working memory