title: [Clinical efficacy of heated humidified high-flow nasal cannula in preventing extubation failure in neonates: a Meta analysis].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of heated humidified high-flow nasal cannula (HHHFNC) in preventing extubation failure in neonates.
  
  
  METHODS
  A literature search was performed using PubMed, Cochrane Library, FMRS, and CNKI to collect the randomized controlled trials (RCTs) and quasi-RCTs which compared the clinical efficacy of HHHFNC and nasal continuous positive airway pressure (NCPAP) in preventing extubation failure in neonates. The identified studies were finally selected after full-text search and quality assessment and then subjected to a Meta analysis using RevMan 5.3.
  
  
  RESULTS
  Five eligible trials involving 1040 neonates were included in the Meta analysis. The Meta analysis showed that there was no significant difference in treatment failure rate between the HHHFNC and the NCPAP groups. The HHHFNC group had significantly lower incidence rates of nasal trauma (OR=0.49, 95% CI: 0.34-0.71, P=0.0001) and pneumothorax (OR=0.27, 95% CI: 0.07-0.97, P=0.04) than the NCPAP group, but there were no significant differences in the duration to reach full oral feedings and the incidence rates of serious adverse events or other complications between the two groups, such as in-hospital mortality, bronchopulmonary dysplasia, intraventricular hemorrhage, necrotizing enterocolitis, and retinopathy of prematurity.
  
  
  CONCLUSIONS
  HHHFNC is safe and effective in preventing extubation failure in neonates.
authors.affiliation: Department of Neonatology, Suzhou Municipal Hospital of Nanjing Medical University, Suzhou, Jiangsu 215002, China. nanyifzt@126.com.
authors.forename: Zong-Tai
authors.initials: ZT
authors.lastname: Feng
authors.forename: Zu-Ming
authors.initials: ZM
authors.lastname: Yang
authors.forename: Dan-Feng
authors.initials: DF
authors.lastname: Gu
authors.forename: Xiao-Lu
authors.initials: XL
authors.lastname: Yang
mesh_terms: D060666:Airway Extubation / Q000379:methods*; D057785:Catheters; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D006358:Hot Temperature; D006801:Humans; D007231:Infant, Newborn; D009296:Nasal Cavity; D063087:Noninvasive Ventilation / Q000379:methods*