title: [Association between CMTM5 gene rs723840 single nucleotide polymorphism and high on asprin platelet reactivity].
abstract: OBJECTIVE
  To elucidate the correlation between the single nucleotide polymorphism of CKLF-like MARVEL transmembrane member 5 (CMTM5) gene rs723840 and the occurrence of high on aspirin platelet reactivity (HAPR).
  
  
  METHODS
  The present study is a case-control study. A total of 210 hospitalized patients in Peking University First Hospital were enrolled. Aspirin response was assessed by 0.5 g/L arachidonic acid (AA)-induced platelet aggregation ratio (PR), and ≥ 3/4 quartile of PR of the population was defined as HAPR. Accordingly all the enrolled 210 coronary artery diseases (CAD) patients were divided into HAPR group and No-HAPR group. The genotypes were determined by polymerase chain reaction (PCR) and sequencing analysis for rs723840 of CMTM5 gene.
  
  
  RESULTS
  The genotype frequencies in rs723840 C>T of CMTM5 gene conformed well to the Hardy-Weinberg equilibrium in both HAPR group and No-HAPR group. Between the two groups, the genotypes frequencies in HAPR and No-HAPR groups were 48.4%, 51.6%, 0.0% and 73.7%, 22.9%, 0.034%, respectively (P=0.004). The C, T allele frequencies were significantly different in the two groups (P=0.031,OR=0.501, 95% CI: 0.264-0.947).
  
  
  CONCLUSIONS
  Our study finds a significant correlation between CMTM5 gene rs723840 polymorphism and high on aspirin platelet reactivity.
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Teng-fei
authors.initials: TF
authors.lastname: Liu
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Jing-wei
authors.initials: JW
authors.lastname: Zhang
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Xia-huan
authors.initials: XH
authors.lastname: Chen
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Xue-ru
authors.initials: XR
authors.lastname: Feng
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Zhong-sheng
authors.initials: ZS
authors.lastname: Bai
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Mei-lin
authors.initials: ML
authors.lastname: Liu
mesh_terms: D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects*; D016022:Case-Control Studies; D018925:Chemokines / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D062792:MARVEL Domain-Containing Proteins / Q000235:genetics*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D010979:Platelet Function Tests; D020641:Polymorphism, Single Nucleotide; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: C525020:CMTM5 protein, human; D018925:Chemokines; D062792:MARVEL Domain-Containing Proteins; D010975:Platelet Aggregation Inhibitors; D025521:Tumor Suppressor Proteins; D001241:Aspirin