title: Association between rs1801133 polymorphism and risk of adult ischemic stroke: Meta-analysis based on case-control studies.
abstract: BACKGROUND
  This study is aimed to quantify the strength of the association between rs1801133 polymorphism and ischemic stroke risk.
  
  
  METHODS
  We have searched Medline, Springer, and Embase for studies investigating the association between rs1801133 polymorphism and ischemic stroke risk. We estimated the pooled odds ratio with its 95% confidence intervals to assess this possible association.
  
  
  RESULTS
  Forty case-control studies comprising 8809 cases and 9130 controls are eligible for this meta-analysis on the basis of relation of rs1801133 polymorphism to ischemic stroke risk. Hardy-Weinberg equilibrium was used to perform in controls for excluding articles. The overall analysis suggested that rs1801133 polymorphism was associated with increased risk of ischemic stroke (ORT versus C=1.16, 95% CI 1.10-1.22; ORTT versus TC+CC=1.32, 95% CI 1.18-1.47; ORTT+TC versus CC=1.11, 95% CI 1.04-1.18). Subgroup analysis showed that T allele was a significant strength between T allele and stroke risk in Asian, Caucasian, male and young-middle populations (OR=1.19, 1.11, 1.30, 1.16, respectively). Compared with TC+CC, TT genotype was found to be a risk factor for developing ischemic stroke in Asian, Caucasian and male (OR=1.41, 1.20, 1.77, respectively). Additionally, TT+TC retained a significant increase for ischemic stroke only in Asian comparable to CC genotype (OR=1.14).
  
  
  CONCLUSIONS
  The rs1801133 polymorphism could be capable of increasing ischemic stroke susceptibility in Asian, male and young-middle populations.
authors.affiliation: The First Hospital of Jing Zhou, Yangtze University, Hangkong street 8, Jingzhou 434000, Hubei, China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: The First Hospital of Jing Zhou, Yangtze University, Hangkong street 8, Jingzhou 434000, Hubei, China.
authors.forename: Ben Yu
authors.initials: BY
authors.lastname: Mao
authors.affiliation: The First Hospital of Jing Zhou, Yangtze University, Hangkong street 8, Jingzhou 434000, Hubei, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: The First Hospital of Jing Zhou, Yangtze University, Hangkong street 8, Jingzhou 434000, Hubei, China.
authors.forename: Xianglin
authors.initials: X
authors.lastname: Cheng
authors.affiliation: The First Hospital of Jing Zhou, Yangtze University, Hangkong street 8, Jingzhou 434000, Hubei, China. Electronic address: mc1220@126.com.
authors.forename: Chuan Xin
authors.initials: CX
authors.lastname: Xu
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000208:ethnology* / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044469:Racial Groups / Q000706:statistics & numerical data; D018570:Risk Assessment / Q000379:methods; D017678:Sex Distribution; D020521:Stroke / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: Ischemic stroke; Meta-analysis; Polymorphism; rs1801133