title: Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis.
abstract: Background and Aims. It is widely accepted that obstructive sleep apnea (OSA) is independently associated with atherosclerosis. Similar to OSA, hypertension (HTN) is a condition associated with atherosclerosis. However, to date, the impact of the simultaneous presence of OSA and HTN on the risk of atherosclerosis has not been extensively studied. The aim of this study was to evaluate the consequences of the coexistence of OSA and HTN on carotid intima-media thickness (IMT) and on inflammatory markers of atherosclerosis (such as interleukin- [IL-] 6 and pentraxin- [PTX-] 3). Methods. The study design allowed us to define 4 groups: (1) controls (n = 30); (2) OSA patients without HTN (n = 30); (3) HTN patients without OSA (n = 30); (4) patients with OSA and HTN (n = 30). In the morning after portable monitoring (between 7 am and 8 am), blood samples were collected, and carotid IMT was measured. Results. Carotid IMT, IL-6, and PTX-3 in OSA normotensive patients and in non-OSA HTN subjects were significantly higher compared to control subjects; in addition, in OSA hypertensive patients they were significantly increased compared to OSA normotensive, non-OSA HTN, or control subjects. Conclusions. OSA and HTN have an additive role in the progression of carotid atherosclerosis and in blood levels of inflammatory markers for atherosclerosis, such as interleukin-6 and pentraxin-3.
authors.affiliation: Institute of Respiratory Disease, University of Bari, Bari, Italy.
authors.forename: Mario Francesco
authors.initials: MF
authors.lastname: Damiani
authors.affiliation: Section of Cardiovascular Disease, University of Bari, Bari, Italy.
authors.forename: Annapaola
authors.initials: A
authors.lastname: Zito
authors.affiliation: Institute of Respiratory Disease, University of Bari, Bari, Italy.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Carratù
authors.affiliation: Institute of Respiratory Disease, University of Bari, Bari, Italy.
authors.forename: Vito Antonio
authors.initials: VA
authors.lastname: Falcone
authors.affiliation: Institute of Respiratory Disease, University of Bari, Bari, Italy.
authors.forename: Elioda
authors.initials: E
authors.lastname: Bega
authors.affiliation: Section of Cardiovascular Disease, University of Bari, Bari, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Scicchitano
authors.affiliation: Section of Cardiovascular Disease, University of Bari, Bari, Italy.
authors.forename: Marco Matteo
authors.initials: MM
authors.lastname: Ciccone
authors.affiliation: Institute of Respiratory Disease, University of Bari, Bari, Italy.
authors.forename: Onofrio
authors.initials: O
authors.lastname: Resta