title: Anatomy and Physiology of Multiscale Modeling and Simulation in Systems Medicine.
abstract: Systems medicine is the application of systems biology concepts, methods, and tools to medical research and practice. It aims to integrate data and knowledge from different disciplines into biomedical models and simulations for the understanding, prevention, cure, and management of complex diseases. Complex diseases arise from the interactions among disease-influencing factors across multiple levels of biological organization from the environment to molecules. To tackle the enormous challenges posed by complex diseases, we need a modeling and simulation framework capable of capturing and integrating information originating from multiple spatiotemporal and organizational scales. Multiscale modeling and simulation in systems medicine is an emerging methodology and discipline that has already demonstrated its potential in becoming this framework. The aim of this chapter is to present some of the main concepts, requirements, and challenges of multiscale modeling and simulation in systems medicine.
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA, UK.
authors.forename: Alexandru
authors.initials: A
authors.lastname: Mizeranschi
authors.affiliation: Chemistry Department, Centre for Computational Science, University College London, 20 Gordon Street, WC1H 0AJ, London, UK.
authors.forename: Derek
authors.initials: D
authors.lastname: Groen
authors.affiliation: Netherlands eScience Center, Science Park 140, 1098 XG, Amsterdam, The Netherlands.
authors.forename: Joris
authors.initials: J
authors.lastname: Borgdorff
authors.affiliation: Computational Science Lab, Institute for Informatics, Faculty of Science, University of Amsterdam, Sciencepark 904, 1098 XH, Amsterdam, The Netherlands.|Advanced Computing Lab, ITMO University, 197101, 49 Kronverkskiy av., St. Petersburg, Russia.
authors.forename: Alfons G
authors.initials: AG
authors.lastname: Hoekstra
authors.affiliation: Computer Science Department, University of Geneva, 7 route de Drize, 1227, Carouge, Switzerland.
authors.forename: Bastien
authors.initials: B
authors.lastname: Chopard
authors.affiliation: Biomedical Sciences Research Institute, University of Ulster, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA, UK. w.dubitzky@ulster.ac.uk.|School of Biomedical Sciences, University of Ulster, Coleraine campus, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA, UK. w.dubitzky@ulster.ac.uk.
authors.forename: Werner
authors.initials: W
authors.lastname: Dubitzky
mesh_terms: D000715:Anatomy; D003198:Computer Simulation; D003628:Database Management Systems; D006801:Humans; D019451:Information Management; D008511:Medicine / Q000379:methods; D008954:Models, Biological; D010827:Physiology; D049490:Systems Biology / Q000379:methods
keywords: Complex disease; Modeling and simulation; Multiscale modeling and simulation; Systems medicine