title: B Cells, Antibodies, and More.
abstract: B cells play a central role in the immunopathogenesis of glomerulonephritides and transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple mechanisms. In addition, B cells contribute to disease pathogenesis in autoimmunity and alloimmunity by presenting antigens as well as providing costimulation and cytokines to T cells. B cells also play an immunomodulatory role in regulating the immune response by secreting cytokines that inhibit disease onset and/or progression. B cell-targeted approaches for treating immune diseases of the kidney and other organs have gained significant momentum. However, much remains to be understood about B-cell biology in order to determine the timing, duration, and context of optimal therapeutic response to B cell-targeted approaches. In this review, we discuss the multifaceted roles of B cells as enhancers and regulators of immunity with relevance to kidney disease and transplantation.
authors.affiliation: Departments of Medicine (Renal-Electrolyte).
authors.forename: William
authors.initials: W
authors.lastname: Hoffman
authors.affiliation: Departments of Medicine (Renal-Electrolyte), Surgery, and Immunology, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, and.
authors.forename: Fadi G
authors.initials: FG
authors.lastname: Lakkis
authors.affiliation: Departments of Medicine (Renal-Electrolyte), Surgery, and Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, and Renal Section, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania gec12@pitt.edu.
authors.forename: Geetha
authors.initials: G
authors.lastname: Chalasani
mesh_terms: D058186:Acute Kidney Injury / Q000276:immunology; D000818:Animals; D000906:Antibodies / Q000502:physiology*; D000938:Antigen-Presenting Cells / Q000502:physiology; D053264:B-Cell Activating Factor / Q000502:physiology; D001402:B-Lymphocytes / Q000502:physiology*; D002454:Cell Differentiation; D005921:Glomerulonephritis / Q000276:immunology; D015433:Glomerulonephritis, Membranous / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D016030:Kidney Transplantation; D008181:Lupus Nephritis / Q000276:immunology; D008213:Lymphocyte Activation
chemical_list: D000906:Antibodies; D053264:B-Cell Activating Factor; C505719:TNFSF13B protein, human
keywords: Antibodies; B regulatory cells; B-Lymphocytes; T-Lymphocytes; autoimmunity; cytokines; glomerulonephritis; graft rejection; immune system diseases; plasma cells