title: Deciphering the role of interleukin-22 in metabolic alterations.
abstract: Inflammatory processes and metabolic alterations are supposed to substantially interact. Recently, cumulating reports describe a profound role of interleukin(IL)-22 in this relationship. IL-22 is a particular kind of immune mediator that is produced by certain lymphocyte populations and regulates the function of several tissue cells but not immune cells. So far, IL-22 was known to plays a fundamental role in the elimination of bacterial infections at border surfaces of the body and to protect tissues from damage. This research highlight article arranges the facts regarding the effects of IL-22 in the context of adiposity and metabolic alterations and postulates a new function of the immune system.
authors.affiliation: Psoriasis Research and Treatment Center, University Hospital Charité, Charitéplatz 1, 10117 Berlin, Germany ; Research Center Immunosciences, University Hospital Charité, Charitéplatz 1, 10117 Berlin, Germany ; Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charité, Charitéplatz 1, 10117 Berlin, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Sabat
authors.affiliation: Psoriasis Research and Treatment Center, University Hospital Charité, Charitéplatz 1, 10117 Berlin, Germany ; Research Center Immunosciences, University Hospital Charité, Charitéplatz 1, 10117 Berlin, Germany ; Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charité, Charitéplatz 1, 10117 Berlin, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Wolk
keywords: Arteriosclerosis; Diabetes mellitus; IL-17; ILC3; Immunity; Metabolic alterations; Obesity; TNF-α; Th1-cells; Th17-cells; Th22-cells