title: Histological changes caused by meclofenamic acid in androgen-independent prostate cancer tumors: evaluation in a mouse model.
abstract: Meclofenamic acid is a nonsteroidal anti-inflammatory drug that has shown therapeutic potential for different types of cancers, including androgen-independent prostate neoplasms. The antitumor effect of diverse nonsteroidal anti-inflammatory drugs has been shown to be accompanied by histological and molecular changes that are responsible for this beneficial effect. The objective of the present work was to analyze the histological changes caused by meclofenamic acid in androgen-independent prostate cancer. Tumors were created in a nude mouse model using PC3 cancerous human cells. Meclofenamic acid (10 mg/kg/day; experimental group, n=5) or saline solution (control group, n=5) was administered intraperitoneally for twenty days. Histological analysis was then carried out on the tumors, describing changes in the cellular architecture, fibrosis, and quantification of cellular proliferation and tumor vasculature. Meclofenamic acid causes histological changes that indicate less tumor aggression (less hypercellularity, fewer atypical mitoses, and fewer nuclear polymorphisms), an increase in fibrosis, and reduced cellular proliferation and tumor vascularity. Further studies are needed to evaluate the molecular changes that cause the beneficial and therapeutic effects of meclofenamic acid in androgen-independent prostate cancer.
authors.affiliation: School of Medicine, University of Colima, Colima, México.|Instituto Estatal de Cancerología, Servicios de Salud del Estado de Colima, Colima, México.
authors.forename: Iván
authors.initials: I
authors.lastname: Delgado-Enciso
authors.affiliation: School of Medicine, University of Colima, Colima, México.
authors.forename: Alejandro D
authors.initials: AD
authors.lastname: Soriano-Hernández
authors.affiliation: School of Medicine, University of Colima, Colima, México.
authors.forename: Alejandrina
authors.initials: A
authors.lastname: Rodriguez-Hernandez
authors.affiliation: School of Medicine, University of Colima, Colima, México.|Instituto Estatal de Cancerología, Servicios de Salud del Estado de Colima, Colima, México.
authors.forename: Héctor R
authors.initials: HR
authors.lastname: Galvan-Salazar
authors.affiliation: School of Medicine, University of Colima, Colima, México.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Montes-Galindo
authors.affiliation: School of Medicine, University of Colima, Colima, México.
authors.forename: Rafael
authors.initials: R
authors.lastname: Martinez-Martinez
authors.affiliation: Chemical Sciences School, University of Colima, Colima, México.
authors.forename: Laura L
authors.initials: LL
authors.lastname: Valdez-Velazquez
authors.affiliation: School of Medicine, University of Colima, Colima, México.
authors.forename: Rafael
authors.initials: R
authors.lastname: Gonzalez-Alvarez
authors.affiliation: School of Medicine, University of Colima, Colima, México.
authors.forename: Francisco
authors.initials: F
authors.lastname: Espinoza-Gómez
authors.affiliation: School of Medicine, University of Colima, Colima, México.
authors.forename: Oscar A
authors.initials: OA
authors.lastname: Newton-Sanchez
authors.affiliation: Servicios de Salud del Estado de Colima, Colima, México.
authors.forename: Agustín
authors.initials: A
authors.lastname: Lara-Esqueda
authors.affiliation: School of Medicine, University of Colima, Colima, México.|Hospital General de Zona Nº1 del IMSS, Colima, México.
authors.forename: Jose
authors.initials: J
authors.lastname: Guzman-Esquivel
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004195:Disease Models, Animal; D005355:Fibrosis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008469:Meclofenamic Acid / Q000494:pharmacology*; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D011467:Prostate / Q000187:drug effects / Q000473:pathology; D064129:Prostatic Neoplasms, Castration-Resistant / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology*; D015203:Reproducibility of Results
chemical_list: D000970:Antineoplastic Agents; D016861:Cyclooxygenase Inhibitors; D008469:Meclofenamic Acid