title: Complete resolution of autoimmune thyroiditis after R-CHOP in a patient with thyroid lymphoma.
abstract: Hashimoto's thyroiditis is a known risk factor for the development of primary thyroid lymphoma. How the treatment of primary thyroid lymphoma influences thyroid function is however largely unknown. This case shows that treatment with R-CHOP chemotherapy can lead to a recovery of thyroid function in a patient with severe hypothyroidism, without thyroid hormone supplementation. Furthermore, this case shows that in patients with primary hypothyroidism and a rapidly enlarging, asymmetrical thyroid, fine needle aspiration should be performed to rule out primary thyroid lymphoma.
authors.affiliation: Department of Internal Medicine, Bronovo Hospital, The Hague, the Netherlands.
authors.forename: M A
authors.initials: MA
authors.lastname: Sleddering
authors.forename: L Th
authors.initials: LT
authors.lastname: Vlasveld
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications*; D008198:Lymph Nodes / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D009333:Neck; D011241:Prednisone / Q000627:therapeutic use; D020127:Recovery of Function; D000069283:Rituximab; D013964:Thyroid Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D013967:Thyroiditis, Autoimmune / Q000150:complications*; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; C571759:R-CHOP protocol; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone