title: Three decades of research on angiogenin: a review and perspective.
abstract: As a member of the vertebrate-specific secreted ribonucleases, angiogenin (ANG) was first isolated and identified solely by its ability to induce new blood vessel formation, and now, it has been recognized to play important roles in various physiological and pathological processes through regulating cell proliferation, survival, migration, invasion, and/or differentiation. ANG exhibits very weak ribonucleolytic activity that is critical for its biological functions, and exerts its functions through activating different signaling transduction pathways in different target cells. A series of recent studies have indicated that ANG contributes to cellular nucleic acid metabolism. Here, we comprehensively review the results of studies regarding the structure, mechanism, and function of ANG over the past three decades. Moreover, current problems and future research directions of ANG are discussed. The understanding of the function and mechanism of ANG in a wide context will help to better delineate its roles in diseases, especially in cancer and neurodegenerative diseases.
authors.affiliation: Institute of Environmental Health, Zhejiang University School of Public Health, Hangzhou 310058, China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310003, China Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Jinghao
authors.initials: J
authors.lastname: Sheng
authors.affiliation: Institute of Environmental Health, Zhejiang University School of Public Health, Hangzhou 310058, China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310003, China Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China zpxu@zju.edu.cn.
authors.forename: Zhengping
authors.initials: Z
authors.lastname: Xu
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D006801:Humans; D007108:Immune Tolerance; D008958:Models, Molecular; D018919:Neovascularization, Physiologic; D019636:Neurodegenerative Diseases / Q000209:etiology; D009696:Nucleic Acids / Q000378:metabolism; D060066:Protein Interaction Maps; D012259:Ribonuclease, Pancreatic / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction
chemical_list: D009696:Nucleic Acids; C046366:angiogenin; D012259:Ribonuclease, Pancreatic
keywords: RNA metabolism; angiogenesis; angiogenin; neurodegeneration disease; tumorigenesis