title: A new cascade halosulfonylation of 1,7-enynes toward 3,4-dihydroquinolin-2(1H)-ones via sulfonyl radical-triggered addition/6-exo-dig cyclization.
abstract: A new cascade three-component halosulfonylation of 1,7-enynes for efficient synthesis of densely functionalized 3,4-dihydroquinolin-2(1H)-ones has been established from readily accessible arylsulfonyl hydrazides and NIS (or NBS). The reaction pathway involves in situ-generated sulfonyl radical-triggered α,β-conjugated addition/6-exo-dig cyclization/radical coupling sequence, resulting in continuous multiple bond-forming events including C-S, C-C and C-I (or C-Br) bonds to rapidly build up molecular complexity.
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, P. R. China. laotu@jsnu.edu.cn jiangchem@jsnu.edu.cn and Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 210009, Jiangsu, P. R. China. weiping@njtech.edu.cn.
authors.forename: Yi-Long
authors.initials: YL
authors.lastname: Zhu
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, P. R. China. laotu@jsnu.edu.cn jiangchem@jsnu.edu.cn and Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, P. R. China. laotu@jsnu.edu.cn jiangchem@jsnu.edu.cn.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Hao
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, P. R. China. laotu@jsnu.edu.cn jiangchem@jsnu.edu.cn.
authors.forename: Ai-Fang
authors.initials: AF
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, P. R. China. laotu@jsnu.edu.cn jiangchem@jsnu.edu.cn and Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 210009, Jiangsu, P. R. China. weiping@njtech.edu.cn.
authors.forename: Jiang-Kai
authors.initials: JK
authors.lastname: Qiu
authors.affiliation: Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 210009, Jiangsu, P. R. China. weiping@njtech.edu.cn.
authors.forename: Ping
authors.initials: P
authors.lastname: Wei
authors.affiliation: Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 210009, Jiangsu, P. R. China. weiping@njtech.edu.cn.
authors.forename: De-Cai
authors.initials: DC
authors.lastname: Wang
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061, USA and Institute of Chemistry & Biomedical Sciences, Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing University, Nanjing 210093, P. R. China.
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, P. R. China. laotu@jsnu.edu.cn jiangchem@jsnu.edu.cn.
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
mesh_terms: D003500:Cyclization; D005609:Free Radicals; D006219:Halogens / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D013450:Sulfones / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D005609:Free Radicals; D006219:Halogens; D013450:Sulfones