title: H2S- and NO-Signaling Pathways in Alzheimer's Amyloid Vasculopathy: Synergism or Antagonism?
abstract: Alzheimer's type of neurodegeneration dramatically affects H2S and NO synthesis and interactions in the brain, which results in dysregulated vasomotor function, brain tissue hypoperfusion and hypoxia, development of perivascular inflammation, promotion of Aβ deposition, and impairment of neurogenesis/angiogenesis. H2S- and NO-signaling pathways have been described to offer protection against Alzheimer's amyloid vasculopathy and neurodegeneration. This review describes recent developments of the increasing relevance of H2S and NO in Alzheimer's disease (AD). More studies are however needed to fully determine their potential use as therapeutic targets in Alzheimer's and other forms of vascular dementia.
authors.affiliation: Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky Krasnoyarsk, Russia.
authors.forename: Alla B
authors.initials: AB
authors.lastname: Salmina
authors.affiliation: Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky Krasnoyarsk, Russia.
authors.forename: Yulia K
authors.initials: YK
authors.lastname: Komleva
authors.affiliation: Experimental and Clinical Research Center, Charité - University Medicine Berlin and the Max Delbrück Center for Molecular Medicine Berlin, Germany.
authors.forename: István A
authors.initials: IA
authors.lastname: Szijártó
authors.affiliation: Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky Krasnoyarsk, Russia.
authors.forename: Yana V
authors.initials: YV
authors.lastname: Gorina
authors.affiliation: Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky Krasnoyarsk, Russia.
authors.forename: Olga L
authors.initials: OL
authors.lastname: Lopatina
authors.affiliation: Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky Krasnoyarsk, Russia.
authors.forename: Galina E
authors.initials: GE
authors.lastname: Gertsog
authors.affiliation: Department of Chemistry and Pharmacy, Friedrich-Alexander-University of Erlangen-Nürnberg Erlangen, Germany.
authors.forename: Milos R
authors.initials: MR
authors.lastname: Filipovic
authors.affiliation: Experimental and Clinical Research Center, Charité - University Medicine Berlin and the Max Delbrück Center for Molecular Medicine Berlin, Germany.
authors.forename: Maik
authors.initials: M
authors.lastname: Gollasch
keywords: Alzheimer disease (AD); H2S; KCNQ channels; NO; obesity; vascular dysfunction