title: Tuberculosis transmission and risk factors in a Chinese antimony mining community.
abstract: METHODS
  An antimony mine in Jiangxi Province, China.
  
  
  OBJECTIVE
  To investigate the incidence of tuberculosis (TB) transmission and associated risk factors in a Chinese antimony mining community.
  
  
  METHODS
  Retrospective cohort study
  
  
  METHODS
  The 15-locus mycobacterial interspersed repetitive unit-variable number of tandem repeats (MIRU-VNTR(15-China)) method was used to determine clustering of patients. A region of difference (RD105) deletion-targeted multiplex polymerase chain reaction was adopted to identify Beijing strains. Risk factors for clustering were assessed.
  
  
  RESULTS
  Of 263 TB patients, 175 were distributed into 35 clusters. Estimated recent transmission of TB was 53.2% within the community. Patients who failed treatment were more likely to be in clusters (adjusted odds ratio [aOR] 0.03, 95%CI 2.12-6.89). Patients with multiresistant isolates were more likely to have failed treatment and to be in a cluster than those carrying a susceptible strain (aOR 0.001, 95%CI 4.89-29.7).
  
  
  CONCLUSIONS
  Individuals who fail treatment are an important source of infection in TB transmission, and multiresistant isolates are mostly responsible for this. TB control plans need to focus on treatment failure cases in the community.
authors.affiliation: Key Laboratory of Medical Molecular Virology, Fudan University, Shanghai, China; Department of Clinical Laboratory, First Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: K-S
authors.initials: KS
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: T
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Respiration, Wuning County People's Hospital, Wuning, China.
authors.forename: R-R
authors.initials: RR
authors.lastname: Lin
authors.affiliation: Department of Clinical Laboratory, Jiangxi Provincial Chest Hospital, Nanchang, China.
authors.forename: Y-P
authors.initials: YP
authors.lastname: Peng
authors.affiliation: Department of Clinical Laboratory, Jiangxi Provincial Chest Hospital, Nanchang, China.
authors.forename: G-C
authors.initials: GC
authors.lastname: Xiong
mesh_terms: D000328:Adult; D000965:Antimony; D000995:Antitubercular Agents / Q000494:pharmacology; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D018562:Disease Transmission, Infectious / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D000067572:Miners; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics; D012189:Retrospective Studies; D012307:Risk Factors; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission
chemical_list: D000995:Antitubercular Agents; D000965:Antimony