title: Salivary acinic cell carcinoma: reappraisal and update.
abstract: Epidemiologic and clinicopathologic features, therapeutic strategies, and prognosis for acinic cell carcinoma of the major and minor salivary glands are critically reviewed. We explore histopathologic, histochemical, electron microscopic and immunohistochemical aspects and discuss histologic grading, histogenesis, animal models, and genetic events. In the context of possible diagnostic difficulties, the relationship to mammary analog secretory carcinoma is probed and a classification is suggested. Areas of controversy or uncertainty, which may benefit from further investigations, are also highlighted.
authors.affiliation: Otorhinolaryngology-Head and Neck Surgery and Leuven Cancer Institute, Department of Oncology-Section Head and Neck Oncology, University Hospitals Leuven, KU Leuven, Leuven, Belgium. vincent.vanderpoorten@uzleuven.be.|European Salivary Gland Society, Geneva, Switzerland. vincent.vanderpoorten@uzleuven.be.
authors.forename: V
authors.identifier: http://orcid.org/0000-0003-1341-829X
authors.initials: V
authors.lastname: Vander Poorten
authors.affiliation: School of Dentistry, University of Liverpool, Liverpool, UK.|Pathology Department, Liverpool Clinical Laboratories, Liverpool, UK.
authors.forename: A
authors.initials: A
authors.lastname: Triantafyllou
authors.affiliation: Southern California Permanente Medical Group, Woodland Hills, CA, USA.
authors.forename: L D R
authors.initials: LD
authors.lastname: Thompson
authors.affiliation: Department of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: J
authors.initials: J
authors.lastname: Bishop
authors.affiliation: Department of Imaging and Pathology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Hauben
authors.affiliation: Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: J
authors.initials: J
authors.lastname: Hunt
authors.affiliation: Department of Pathology, Faculty of Medicine in Plzen, Charles, University Prague, Prague, Czech Republic.
authors.forename: A
authors.initials: A
authors.lastname: Skalova
authors.affiliation: European Salivary Gland Society, Geneva, Switzerland.|Department of Pathology, Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Stenman
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: R P
authors.initials: RP
authors.lastname: Takes
authors.affiliation: University Pathologists, Fall River, MA, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Gnepp
authors.affiliation: Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal.
authors.forename: H
authors.initials: H
authors.lastname: Hellquist
authors.affiliation: Department of Pathology, Beth Israel Medical Center, New York, NY, USA.
authors.forename: B
authors.initials: B
authors.lastname: Wenig
authors.affiliation: Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: D
authors.initials: D
authors.lastname: Bell
authors.affiliation: University of Udine School of Medicine, Udine, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Rinaldo
authors.affiliation: Coordinator of the International Head and Neck Scientific Group, Padua, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ferlito
mesh_terms: D000818:Animals; D018267:Carcinoma, Acinar Cell / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D003937:Diagnosis, Differential; D004195:Disease Models, Animal; D006801:Humans; D008854:Microscopy, Electron; D010306:Parotid Gland; D011300:Preoperative Care; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D012470:Salivary Glands, Minor
keywords: Acinic cell carcinoma; Mammary analog secretory carcinoma; Pathology; Prognosis; Salivary glands; Therapy