title: Comparison of the mucoadhesive properties of thiolated polyacrylic acid to thiolated polyallylamine.
abstract: Synthetic polymers, polyacrylic acid (PAA) and polyallylamine (PAAm), were thiolated using different methods of thiolation. Both polymers resulted in comparable thiol contents, thus allowing for the direct comparison of mucoadhesive and cohesive properties between the well-established thiolated PAA and the more novel thiolated PAAm. Thiolation of both polymers improved the swelling ability and the cohesive and mucoadhesive properties in comparison to unmodified control samples. In this study, it was shown that the swelling abilities of the thiolated PAAm sample were far greater than that of the thiolated PAA sample which, in turn, affected the drug release profile of the thiolated PAAm sample. Importantly, however, the mucoadhesive properties of thiolated PAAm were equivalent to that of the thiolated PAA sample as demonstrated by both the adhesion times on porcine intestinal tissue as measured by the rotating cylinder method and by rheological studies with a mucin solution. This study demonstrates the potential thiolated polyallylamine has as a mucoadhesive drug delivery device.
authors.affiliation: Pharmaceutical and Molecular Biotechnology Research Centre, Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland. Electronic address: sduggan@wit.ie.
authors.forename: Sarah
authors.initials: S
authors.lastname: Duggan
authors.affiliation: Pharmaceutical and Molecular Biotechnology Research Centre, Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland.
authors.forename: Orla
authors.initials: O
authors.lastname: O'Donovan
authors.affiliation: Pharmaceutical and Molecular Biotechnology Research Centre, Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland.
authors.forename: Eleanor
authors.initials: E
authors.lastname: Owens
authors.affiliation: Pharmaceutical and Molecular Biotechnology Research Centre, Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland.
authors.forename: Elaine
authors.initials: E
authors.lastname: Duggan
authors.affiliation: Pharmaceutical and Molecular Biotechnology Research Centre, Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland.
authors.forename: Helen
authors.initials: H
authors.lastname: Hughes
authors.affiliation: Pharmaceutical and Molecular Biotechnology Research Centre, Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, Ireland.
authors.forename: Wayne
authors.initials: W
authors.lastname: Cummins
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry* / Q000378:metabolism*; D000268:Adhesiveness; D000818:Animals; D007413:Intestinal Mucosa / Q000378:metabolism*; D009924:Organ Culture Techniques; D011073:Polyamines / Q000737:chemistry* / Q000378:metabolism*; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000378:metabolism; D013552:Swine
chemical_list: D000180:Acrylic Resins; D011073:Polyamines; D011108:Polymers; D013438:Sulfhydryl Compounds; C063994:polyallylamine; C006903:carbopol 940
keywords: Mucoadhesion; Polyacrylic acid; Polyallylamine; Thiolation; Traut’s reagent