title: Thyroid Sporadic Goiter with Adult Heterotopic Bone Formation.
abstract: Thyroid heterotopic bone formation (HBF) in goiter is a rare finding. Five thyroid resection specimens were analyzed for HBF. The results were correlated with clinicomorphological features. All patients were women (33-82 years). The preoperative diagnosis was thyroid goiter or nodule. Treatment consisted in thyroidectomy and lobectomy (3 and 2, resp.). Microscopy showed sporadic nodular goiter. Malformative blood vessels and vascular calcifications were seen in intra- and extrathyroid location (5 and 3, resp.). The number and size of HBFs (total: 28) ranged between 1 and 23/thyroid gland (one bilateral) and 1 and 10 mm, respectively. Twelve HBFs were in contact with the thyroid capsule. Most were extranodular (21, versus 6 intranodular). The medical history was positive for dyslipidemia, hyperglycemia, renal dysfunction, and hyperuricemia (2, 3, and 3 cases and 1 case, resp.) without any parathyroid abnormality. In conclusion, thyroid HBF may be characterized by subcapsular or extranodular location, various size (usually ≥2 mm), and vascular calcifications and malformations. Features of metabolic syndrome and renal dysfunction may be present, but their exact role in the pathogenesis of HBFs remains to be elucidated.
authors.affiliation: Service d'Anatomie Pathologique, APHP GHU Avicenne, UFR Médecine, Université Paris Nord Sorbonne Cité, 125 rue Stalingrad, 93009 Bobigny, France.
authors.forename: Adriana
authors.initials: A
authors.lastname: Handra-Luca
authors.affiliation: Service Medecine Nucleaire, APHP GHU Avicenne, 93009 Bobigny, France.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Dumuis-Gimenez
authors.affiliation: Service d'Anatomie Pathologique, APHP GHU Avicenne, UFR Médecine, Université Paris Nord Sorbonne Cité, 125 rue Stalingrad, 93009 Bobigny, France.
authors.forename: Mouna
authors.initials: M
authors.lastname: Bendib
authors.affiliation: Division of Endocrinology, Police Medical Centre, Monastiriou 326, 54627 Thessaloniki, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Anagnostis