title: Apoptosis in Drosophila: which role for mitochondria?
abstract: It is now well established that the mitochondrion is a central regulator of mammalian cell apoptosis. However, the importance of this organelle in non-mammalian apoptosis has long been regarded as minor, mainly because of the absence of a crucial role for cytochrome c in caspase activation. Recent results indicate that the control of caspase activation and cell death in Drosophila occurs at the mitochondrial level. Numerous proteins, including RHG proteins and proteins of the Bcl-2 family that are key regulators of Drosophila apoptosis, constitutively or transiently localize in mitochondria. These proteins participate in the cell death process at different levels such as degradation of Diap1, a Drosophila IAP, production of mitochondrial reactive oxygen species or stimulation of the mitochondrial fission machinery. Here, we review these mitochondrial events that might have their counterpart in human.
authors.affiliation: Laboratoire de Génétique et Biologie Cellulaire, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, 2 Avenue de la Source de la Bièvre, 78180, Montigny-le-Bretonneux, France.|Laboratoire de Génétique Moléculaire et Physiologique, Ecole Pratique des Hautes Etudes, PSL Research University, 78180, Montigny-le-Bretonneux, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Clavier
authors.affiliation: Laboratoire de Génétique et Biologie Cellulaire, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, 2 Avenue de la Source de la Bièvre, 78180, Montigny-le-Bretonneux, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Rincheval-Arnold
authors.affiliation: Laboratoire de Génétique et Biologie Cellulaire, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, 2 Avenue de la Source de la Bièvre, 78180, Montigny-le-Bretonneux, France.|Laboratoire de Génétique Moléculaire et Physiologique, Ecole Pratique des Hautes Etudes, PSL Research University, 78180, Montigny-le-Bretonneux, France.
authors.forename: Jessie
authors.initials: J
authors.lastname: Colin
authors.affiliation: Laboratoire de Génétique et Biologie Cellulaire, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, 2 Avenue de la Source de la Bièvre, 78180, Montigny-le-Bretonneux, France.|Laboratoire de Génétique Moléculaire et Physiologique, Ecole Pratique des Hautes Etudes, PSL Research University, 78180, Montigny-le-Bretonneux, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Mignotte
authors.affiliation: Laboratoire de Génétique et Biologie Cellulaire, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, 2 Avenue de la Source de la Bièvre, 78180, Montigny-le-Bretonneux, France. isabelle.guenal@uvsq.fr.
authors.forename: Isabelle
authors.identifier: http://orcid.org/0000-0003-1186-1458
authors.initials: I
authors.lastname: Guénal
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D020169:Caspases / Q000378:metabolism; D045304:Cytochromes c / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics / Q000378:metabolism*; D008928:Mitochondria / Q000235:genetics / Q000502:physiology*; D063154:Mitochondrial Dynamics; D009154:Mutation; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C111891:DIAP1 protein, Drosophila; D029721:Drosophila Proteins; D051034:Inhibitor of Apoptosis Proteins; D017382:Reactive Oxygen Species; D045304:Cytochromes c; D020169:Caspases
keywords: Apoptosis; Bcl-2 family proteins; Drosophila; IAP; Mitochondria; Mitochondrial dynamics; RHG proteins; Reactive oxygen species