title: NQO1 C609T Polymorphism is Associated with Coronary Artery Disease in a Gender-Dependent Manner.
abstract: Findings on the association of NQO1 C609T polymorphism in the NQO1 gene and cardiovascular disease susceptibility are controversial. The objective of the current study was to examine the relationship between this polymorphism and the presence and severity of angiographically determined coronary artery disease (CAD). One-hundred and forty-five patients with newly diagnosed angiographically documented CAD (≥50 % luminal stenosis of any coronary vessel) as case group were compared to 139 controls (subjects with no luminal stenosis at coronary arteries). The presence of C609T polymorphism was analyzed using polymerase chain reaction-based restriction fragment length polymorphism. Among total population, those with combined CT/TT (T allele carrier) genotype showed a trend toward lower odds of CAD compared to those with CC (wild type) genotype, but it did not reach a statistically significant level (p = 0.061). When data were analyzed separately for men or women, CT + TT group as compared to CC genotype was associated with decreased odds of CAD in women (adjusted OR 0.4, 95 % CI 0.2-0.9; p = 0.043), but not in men (adjusted OR 0.8, 95 % CI 0.3-1.9; p = 0.612). The C609T polymorphism within NQO1 is independently associated with CAD in women, but no association was observed in whole study population or in men.
authors.affiliation: Department of Clinical Pathology and Laboratory Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, P.O. Box 1411713138, Iran.
authors.forename: Mohammadali
authors.initials: M
authors.lastname: Boroumand
authors.affiliation: Department of Clinical Pathology and Laboratory Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, P.O. Box 1411713138, Iran.|Department of Pharmacology and Toxicology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, P.O. Box 7616911319, Iran.
authors.forename: Leyla
authors.initials: L
authors.lastname: Pourgholi
authors.affiliation: Department of Cardiac Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, P.O. Box 1411713138, Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Goodarzynejad
authors.affiliation: Department of Clinical Pathology and Laboratory Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, P.O. Box 1411713138, Iran.
authors.forename: Shayan
authors.initials: S
authors.lastname: Ziaee
authors.affiliation: Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, P.O. Box 141556451, Iran.
authors.forename: Azita
authors.initials: A
authors.lastname: Hajhosseini-Talasaz
authors.affiliation: Department of Clinical Pathology and Laboratory Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, P.O. Box 1411713138, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Sotoudeh-Anvari
authors.affiliation: Department of Pharmacology and Toxicology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, P.O. Box 7616911319, Iran. alimandegary@yahoo.com.|Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, P.O. Box 7616911319, Iran. alimandegary@yahoo.com.
authors.forename: Ali
authors.initials: A
authors.lastname: Mandegary
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000201:enzymology / Q000235:genetics*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human
keywords: Coronary artery disease; Gender; NAD(P)H: quinone oxidoreductase 1; NQO1 C609T polymorphism