title: [Lab-on-a-chip systems in the point-of-care diagnostics].
abstract: The need in modern medicine for near-patient diagnostics being able to accelerate therapeutic decisions and possibly replacing laboratory measurements is significantly growing. Reliable and cost-effective bioanalytical measurement systems are required which - acting as a micro-laboratory - contain integrated biomolecular recognition, sensing, signal processing and complex microfluidic sample preparation modules. These micro- and nanofabricated Lab-on-a-chip systems open new perspectives in the diagnostic supply chain, since they are able even for quantitative, high-precision and immediate analysis of special disease specific molecular markers or their combinations from a single drop of sample. Accordingly, crucial requirements regarding the instruments and the analytical methods are the high selectivity, extremely low detection limit, short response time and integrability into the healthcare information networks. All these features can make the hierarchical examination chain shorten, and revolutionize laboratory diagnostics, evolving a brand new situation in therapeutic intervention.
authors.affiliation: 77 Elektronika Kft. Budapest, Fehérvári út 98., 1116.
authors.forename: Barnabás
authors.initials: B
authors.lastname: Szabó
authors.affiliation: 77 Elektronika Kft. Budapest, Fehérvári út 98., 1116.
authors.forename: András
authors.initials: A
authors.lastname: Borbíró
authors.affiliation: BioMEMS Csoport, Magyar Tudományos Akadémia-Energiatudományi Kutatóközpont-Műszaki Fizikai és Anyagtudományi Intézet Budapest.
authors.forename: Péter
authors.initials: P
authors.lastname: Fürjes
mesh_terms: D015415:Biomarkers; D015374:Biosensing Techniques / Q000295:instrumentation / Q000639:trends; D006801:Humans; D056656:Lab-On-A-Chip Devices / Q000639:trends; D025202:Molecular Diagnostic Techniques / Q000295:instrumentation / Q000379:methods / Q000639:trends; D057089:Pathology, Molecular / Q000295:instrumentation / Q000379:methods / Q000639:trends; D019095:Point-of-Care Systems / Q000639:trends; D013048:Specimen Handling / Q000639:trends
chemical_list: D015415:Biomarkers
keywords: Lab-on-a-chip; betegágy melletti diagnosztika; biomarker; biosensor; bioszenzor; in vitro diagnostics; in vitro diagnosztika; information system; információs rendszer; laboratórium egy chipen; microfluidics; mikrofluidika; point-of-care diagnostics