title: Association of Interleukin-10-1082A/G Polymorphism with Idiopathic Recurrent Miscarriage: A Systematic Review and Meta-Analysis.
abstract: OBJECTIVE
  This systematic review and meta-analysis aimed to synthesize and assess the correlation between the interleukin-10 (IL-10)-1082A/G polymorphism and idiopathic recurrent miscarriage (IRM) using relevant studies.
  
  
  METHODS
  Five electronic databases (Cochrane Library of Systematic Reviews, PubMed, EMBASE, Web of Science, and Google Scholar) were comprehensively searched up to August 2015. Data were extracted independently by two members of our team.
  
  
  RESULTS
  The meta-analysis of 13 eligible studies suggested a recessive effect of the G allele (-1082A/G polymorphism) for IRM risk.
  
  
  CONCLUSIONS
  The pooled evidence demonstrated that the GG genotype increased IRM risk.
authors.affiliation: Department of Clinical Laboratory, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Peng
authors.affiliation: Department of Clinical Laboratory, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, China.
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Lv
authors.affiliation: Department of Clinical Laboratory, Liuzhou Hospital of Traditional Chinese Medicine, Liuzhou, Guangxi, China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Clinical Laboratory, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China.
authors.forename: Shengming
authors.initials: S
authors.lastname: Dai
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011247:Pregnancy
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
keywords: IL-10; Idiopathic recurrent miscarriage; meta-analysis; polymorphism