title: Enhanced Analytical Performance of Paper Microfluidic Devices by Using Fe3O4 Nanoparticles, MWCNT, and Graphene Oxide.
abstract: Spheres, tubes, and planar-shaped nanomaterials as Fe3O4 nanoparticles (MNPs), multiwalled carbon nanotubes (MWCNT), and graphene oxide (GO) were used for the first time to treat microfluidic paper-based analytical devices (μPADs) and create a biocompatible layer with high catalytic surface. Once glucose measurements are critical for diabetes or glycosuria detection and monitoring, the analytical performance of the proposed devices was studied by using bienzymatic colorimetric detection of this carbohydrate. The limit of detection values achieved for glucose with μPADs treated with MNPs, MWCNT, and GO were 43, 62, and 18 μM, respectively. The paper surface modification solves problems associated with the lack of homogeneity on color measurements that compromise the sensitivity and detectability levels in clinical diagnosis.
authors.affiliation: Instituto de Química, Universidade Federal de Goiás , Goiânia, GO 74690-900, Brazil.|Laboratorio de Biosensores y Bioanálisis (LABB), Departamento de Química Biológica e IQUIBICEN-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA) , Pabellón 2, Ciudad Universitaria, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Federico
authors.initials: F
authors.lastname: Figueredo
authors.affiliation: Instituto de Química, Universidade Federal de Goiás , Goiânia, GO 74690-900, Brazil.
authors.forename: Paulo T
authors.initials: PT
authors.lastname: Garcia
authors.affiliation: Laboratorio de Biosensores y Bioanálisis (LABB), Departamento de Química Biológica e IQUIBICEN-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA) , Pabellón 2, Ciudad Universitaria, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Cortón
authors.affiliation: Instituto de Química, Universidade Federal de Goiás , Goiânia, GO 74690-900, Brazil.
authors.forename: Wendell K T
authors.initials: WK
authors.lastname: Coltro
mesh_terms: D003116:Color; D005290:Ferric Compounds / Q000737:chemistry*; D005947:Glucose / Q000032:analysis; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D056656:Lab-On-A-Chip Devices; D053758:Nanoparticles / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010209:Paper
chemical_list: D005290:Ferric Compounds; D037742:Nanotubes, Carbon; C000499:ferric oxide; D006108:Graphite; D005947:Glucose
keywords: carbon nanotubes; cellulose; clinical diagnostics; colorimetric biosensors; digital image analysis; magnetic nanoparticles; paper microfluidics