title: Ischemic stroke outcome: A review of the influence of post-stroke complications within the different scenarios of stroke care.
abstract: Stroke remains one of the main causes of death and disability worldwide. The challenge of predicting stroke outcome has been traditionally assessed from a general point of view, where baseline non-modifiable factors such as age or stroke severity are considered the most relevant factors. However, after stroke occurrence, some specific complications such as hemorrhagic transformations or post stroke infections, which lead to a poor outcome, could be developed. An early prediction or identification of these circumstances, based on predictive models including clinical information, could be useful for physicians to individualize and improve stroke care. Furthermore, the addition of biological information such as blood biomarkers or genetic polymorphisms over these predictive models could improve their prognostic value. In this review, we focus on describing the different post-stroke complications that have an impact in short and long-term outcome across different time points in its natural history and on the clinical-biological information that might be useful in their prediction.
authors.affiliation: Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Universitat Autònoma de Barcelona, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Bustamante
authors.affiliation: Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Universitat Autònoma de Barcelona, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: García-Berrocoso
authors.affiliation: Stroke Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: Noelia
authors.initials: N
authors.lastname: Rodriguez
authors.affiliation: Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Universitat Autònoma de Barcelona, Spain.
authors.forename: Victor
authors.initials: V
authors.lastname: Llombart
authors.affiliation: Stroke Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: Marc
authors.initials: M
authors.lastname: Ribó
authors.affiliation: Stroke Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Molina
authors.affiliation: Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Universitat Autònoma de Barcelona, Spain; Stroke Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Electronic address: 31862jmv@comb.cat.
authors.forename: Joan
authors.initials: J
authors.lastname: Montaner
mesh_terms: D015415:Biomarkers / Q000097:blood; D015897:Comorbidity; D006801:Humans; D063868:Patient Outcome Assessment; D011014:Pneumonia / Q000453:epidemiology*; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications* / Q000401:mortality*; D020246:Venous Thrombosis / Q000453:epidemiology*
chemical_list: D015415:Biomarkers
keywords: Biological markers; Infection; Outcome assessment; Reperfusion; Stroke