title: Multifunctional commercially pure titanium for the improvement of bone integration: Multiscale topography, wettability, corrosion resistance and biological functionalization.
abstract: The objects of this research are commercially pure titanium surfaces, with multifunctional behavior, obtained through a chemical treatment and biological functionalization. The explored surfaces are of interest for dental implants, in contact with bone, where several simultaneous and synergistic actions are needed, in order to get a fast and effective osseointegration. The here described modified surfaces present a layer of titanium oxide, thicker than the native one, with a multi-scale surface topography (a surface roughness on the nano scale, which can be overlapped to a micro or macro roughness of the substrate) and a high density of OH groups, that increase surface wettability, induce a bioactive behavior (hydroxyapatite precipitation in simulated body fluid) and make possible the grafting of biomolecules (alkaline phosphatase, ALP, in the present research). The surface oxide is an efficient barrier against corrosion, with passive behavior both with and without application of an external voltage.
authors.affiliation: Politecnico di Torinoe, DISAT Department, Corso Duca degli Abruzzi, 24-10129 Torino, Italy. Electronic address: sara.ferraris@polito.it.
authors.forename: Sara
authors.initials: S
authors.lastname: Ferraris
authors.affiliation: Politecnico di Torinoe, DISAT Department, Corso Duca degli Abruzzi, 24-10129 Torino, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Vitale
authors.affiliation: Politecnico di Torinoe, DISAT Department, Corso Duca degli Abruzzi, 24-10129 Torino, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Bertone
authors.affiliation: Politecnico di Torinoe, DISAT Department, Corso Duca degli Abruzzi, 24-10129 Torino, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Guastella
authors.affiliation: NobilBio Ricerche, Portacomaro, AT, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Cassinelli
authors.affiliation: Division of Surface and Corrosion Science, School of Chemical Science and Engineering, Royal Institute of Technology, Drottning Kristinas Väg. 51 SE-100 44, Stockholm, Sweden.
authors.forename: Jinshan
authors.initials: J
authors.lastname: Pan
authors.affiliation: Politecnico di Torinoe, DISAT Department, Corso Duca degli Abruzzi, 24-10129 Torino, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Spriano
mesh_terms: D000469:Alkaline Phosphatase / Q000737:chemistry / Q000378:metabolism; D003343:Corrosion; D015921:Dental Implants; D017886:Durapatite / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D017155:Wettability
chemical_list: D015921:Dental Implants; D017886:Durapatite; D014025:Titanium; D000469:Alkaline Phosphatase
keywords: Bioactivity; Dental implants; Functionalization; Nanostructure; Titanium