title: [Safety and efficacy of sensor augmented insulin pump versus double C therapy in poorly controlled type 2 diabetes].
abstract: OBJECTIVE
  To compare the efficacy, safety and efficiency of sensor augmented insulin pump (SAP) versus double-C therapy in poorly controlled type 2 diabetes (T2DM).
  
  
  METHODS
  A total of 81 patients with T2DM, HbA1c ≥ 9%, were divided randomly into SAP or continuous subcutaneous insulin infusion and retrospective continuous glucose monitoring (double C) group for both 6 days.
  
  
  RESULTS
  In both groups, mean blood glucose (MBG), mean amplitude of glycemic excursion (MAGE) and 24 h area under the curve at 10 (AUC10) significantly decreased after therapy (P < 0.05). These parameters in SAP group were lower than those in double C group (P < 0.05). No significant difference existed in 24 h area under the curve at 3.9 (AUC3.9) (P > 0.05). Compared with double C group, time spend to-blood glucose-target was shorter and in-target range proportion higher in SAP group (P < 0.05). Logistic regression analysis showed that 2 h C peptide (CP)/fasting C peptide (FCP), HbA1c and sensor alert on (all P < 0.05) were independently correlated with up-to blood glucose target.
  
  
  CONCLUSIONS
  Compared with double C, SAP therapy may decrease blood glucose (BG), reduce glucose fluctuation and improve up-to target proportions without a higher risk of hypoglycemia.
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China.
authors.forename: Chunhong
authors.initials: C
authors.lastname: Shi
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Ji
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China; Email: bairan5556@163.com.
authors.forename: Ran
authors.initials: R
authors.lastname: Bai
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China.
authors.forename: Yongbo
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China.
authors.forename: Xueyang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China.
authors.forename: Jianling
authors.initials: J
authors.lastname: Du
mesh_terms: D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2; D006801:Humans; D006946:Hyperinsulinism; D007003:Hypoglycemia; D007328:Insulin; D007332:Insulin Infusion Systems; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose; D007328:Insulin