title: Acute myeloid leukemia of a primary hepatic carcinoma patient after liver transplantation: a case report and literature review.
abstract: Living donor liver transplantation (LDLT) is an important means to treat end-stage liver disease. Although effective immunosuppressant medication greatly assists the survival of patients, it is likely to promote infections and cancer. Acute leukemia (AL) is a rare complication after LDLT and up to now only 1 case of post-transplantation AL has occurred in our liver transplantation center after more than 1,600 LDLT interventions since 1993. In the present report, we describe a rare case of subsequent acute myeloid leukemia (AML), 27 months after LDLT and review the literature of this infrequent complication.
authors.affiliation: The Bone Marrow Transplantation Center & Multiple Myeloma Treatment Center, The First Affiliated Hospital of Medical College, Zhejiang University Hangzhou 310003, China.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Wu
authors.affiliation: The Bone Marrow Transplantation Center & Multiple Myeloma Treatment Center, The First Affiliated Hospital of Medical College, Zhejiang University Hangzhou 310003, China.
authors.forename: Meng-Meng
authors.initials: MM
authors.lastname: Dong
authors.affiliation: Department of Chemotherapy, Zhejiang Provincial People's Hospital Hangzhou 310014, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Chen
authors.affiliation: The Bone Marrow Transplantation Center & Multiple Myeloma Treatment Center, The First Affiliated Hospital of Medical College, Zhejiang University Hangzhou 310003, China.
authors.forename: Jing-Song
authors.initials: JS
authors.lastname: He
authors.affiliation: The Bone Marrow Transplantation Center & Multiple Myeloma Treatment Center, The First Affiliated Hospital of Medical College, Zhejiang University Hangzhou 310003, China.
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.affiliation: The Bone Marrow Transplantation Center & Multiple Myeloma Treatment Center, The First Affiliated Hospital of Medical College, Zhejiang University Hangzhou 310003, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cai
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000601:surgery*; D017809:Fatal Outcome; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000209:etiology* / Q000473:pathology; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D007166:Immunosuppressive Agents; D000509:alpha-Fetoproteins
keywords: Acute myeloid leukemia; alpha-fetoprotein; hepatic carcinoma; liver transplantation; metastases