title: The requirement of iron transport for lymphocyte function.
abstract: Iron is essential in multiple cellular processes and is especially critical for cellular respiration and division. A new study identified a mutation affecting the iron import receptor TfR1 as the cause of a human primary immunodeficiency, illuminating the importance of iron in immune cell function.
authors.affiliation: Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA, and in the Division of Translational Medicine, Sidra Medical and Research Center, Doha, Qatar.
authors.forename: Bernice
authors.initials: B
authors.lastname: Lo
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics* / Q000276:immunology*; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics*; D008297:Male; D020125:Mutation, Missense; D011990:Receptors, Transferrin / Q000235:genetics* / Q000276:immunology*
chemical_list: D015703:Antigens, CD; C068126:CD71 antigen; D011990:Receptors, Transferrin