title: Pyoderma Gangrenosum with Ulcerative Colitis Successfully Treated by the Combination of Granulocyte and Monocyte Adsorption Apheresis and Corticosteroids.
abstract: A 36-year-old woman was admitted to our hospital due to swelling and redness of the left lateral malleolus and dorsum of the left foot with severe pain, with a flare-up of ulcerative colitis (UC). A pathologic examination by skin biopsy led to a diagnosis of pyoderma gangrenosum (PG). She was treated with the intravenous administration of prednisolone (60 mg/day), and granulocyte and monocyte adsorption apheresis (GMA) was performed twice-a-week for 5 weeks. This treatment dramatically improved both the skin and colonic mucosal lesions. These results suggest that a combination of GMA and corticosteroids might be recommendable to induce the remission of serious PG complicated with UC.
authors.affiliation: Division of Gastroenterology, Kusatsu General Hospital, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Ohno
authors.forename: Shigeki
authors.initials: S
authors.lastname: Koyama
authors.forename: Mariko
authors.initials: M
authors.lastname: Ohara
authors.forename: Kazumi
authors.initials: K
authors.lastname: Shimamoto
authors.forename: Yu
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Fumiyasu
authors.initials: F
authors.lastname: Nakamura
authors.forename: Kazuki
authors.initials: K
authors.lastname: Mitsuru
authors.forename: Akira
authors.initials: A
authors.lastname: Andoh
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D001781:Blood Component Removal / Q000379:methods*; D003093:Colitis, Ulcerative / Q000150:complications / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007937:Leukapheresis; D009000:Monocytes / Q000276:immunology*; D011239:Prednisolone / Q000008:administration & dosage*; D017511:Pyoderma Gangrenosum / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D011239:Prednisolone