title: Histone deacetylase activity and recurrent bacterial bronchitis in severe eosinophilic asthma.
abstract: An increase in P13 Kinase activity and an associated reduction in histone deacetylase activity may contribute to both relative steroid insensitivity in patients with severe eosinophilic asthma and impaired macrophage scavenger function and susceptibility to recurrent infective bronchitis that may, in turn, contribute to further steroid insensitivity.
authors.affiliation: Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Zuccaro
authors.affiliation: Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Cox
authors.affiliation: Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Pray
authors.affiliation: Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Radford
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Novakowski
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Dorrington
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.|Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: M G
authors.initials: MG
authors.lastname: Surette
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Bowdish
authors.affiliation: Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Nair
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism*; D001424:Bacterial Infections / Q000150:complications* / Q000382:microbiology*; D001991:Bronchitis / Q000150:complications* / Q000382:microbiology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013183:Sputum / Q000201:enzymology / Q000276:immunology; D055815:Young Adult
keywords: eosinophilic asthma; histone deacetylase; macrophage receptor with collagenous structure; sputum cell counts