title: Novel stent in the palliation of malignant esophageal strictures: a retrospective study.
abstract: The placement of metal stents is often used as a palliative treatment for malignant esophageal stenosis. We designed a novel stent that has been used clinically since 2011, and we therefore performed a retrospective study to compare the therapeutic effects of this novel metal stent to a conventional partially covered metal stent in patients with malignant esophageal strictures. The records of 201 consecutive patients who underwent placement of either the conventional partially covered metal stents (Group A, n = 92) or the new metal stents (Group B, n = 109) in the Endoscopy Center of General Hospital of Chengdu Military Command from October 2008 to March 2013 were reviewed. The median dysphagia score significantly improved in both groups 1 week following stent placement (P < 0.001). No significant differences were observed in success rate (P = 0.910) or the complication rate (P = 0.426) between groups. Six months after stent placement, recurrent dysphagia due to stent migration, tissue ingrowth or overgrowth or food obstruction occurred in 45% and 29% of patients in the conventional stent and new stent groups, respectively. The results of this retrospective study indicate that the new modified self-expandable metal stents (SEMS) is at least as safe and effective as the conventional partially covered SEMS in treatment of malignant esophageal strictures.
authors.affiliation: Department of Digestion, General Hospital of Chengdu Military Command, Chengdu, Sichuan Province, China.
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Digestion, General Hospital of Chengdu Military Command, Chengdu, Sichuan Province, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Ni
authors.affiliation: Department of Biomedical Engineering, Fourth Military Medical University, Xi'an, China.
authors.forename: D
authors.initials: D
authors.lastname: Jing
authors.affiliation: Department of Anaesthesiology, Children's Hospital of Fudan University, Shanghai, China
authors.forename: L
authors.initials: L
authors.lastname: He
authors.affiliation: CAS Key Laboratory of Mechanical Behavior and Design of Materials, University of Science and Technology of China, Hefei, Anhui, PRC.
authors.forename: L
authors.initials: L
authors.lastname: Qiao
authors.affiliation: Xuzhou Medical College Graduate Academy, Xuzhou, China.
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: Wei
authors.affiliation: Department of Basic Medicine, Institute of Immunology, Third Military Medical University of PLA, Chongqing, China.
authors.forename: M
authors.initials: M
authors.lastname: Jiang
authors.affiliation: College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
authors.forename: S
authors.initials: S
authors.lastname: Tang
authors.affiliation: Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York, USA.
authors.forename: H
authors.initials: H
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003680:Deglutition Disorders / Q000209:etiology; D004938:Esophageal Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D004940:Esophageal Stenosis / Q000150:complications / Q000473:pathology / Q000601:surgery*; D004945:Esophagoscopy / Q000379:methods*; D005260:Female; D005548:Foreign-Body Migration / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010166:Palliative Care / Q000379:methods*; D011183:Postoperative Complications / Q000209:etiology; D012189:Retrospective Studies; D000069322:Self Expandable Metallic Stents / Q000009:adverse effects; D012720:Severity of Illness Index; D016896:Treatment Outcome
keywords: esophageal neoplasm; esophageal stenosis; palliative care; stent