title: Integrin (αvβ3) Targeted RGD Peptide Based Probe for Cancer Optical Imaging.
abstract: Integrins have an important impact on the regulation of normal and tumor cell migration and survival, especially the integrin αvβ3 and its role in angiogenesis and tumor metastasis. Owing to the role of integrins, non-invasive imaging of αvβ3 expression in diseased tissue will be of great benefit in directing adjuvant therapy for cancer patients. To this end, RGD peptide based probes for optical imaging have emerged as a real-time, sensitive, and noninvasive approach for visualization, localization, and measurement of cancer in vivo. With the advantages of optical imaging such as sensitivity, cost effectiveness, and non-invasion, the past decades have witnessed the rapid development of integrin- targeted optical probes and its wide applications in cancer research. In this review, we present and introduce numerous approaches by the term "RGD motif based optical imaging probes" with respect to their probe design strategies and applications. Additionally, a variety of labels such as QDs, UCLs and near-infrared fluorochrome used in these optical imaging probes are also discussed.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Liu
authors.forename: Lun
authors.initials: L
authors.lastname: Yu
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Wang
authors.forename: Xintong
authors.initials: X
authors.lastname: Zhang
authors.forename: Meihui
authors.initials: M
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410078, China. wbzeng@hotmail.com.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Zeng
mesh_terms: D014408:Biomarkers, Tumor; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000737:chemistry / Q000378:metabolism*; D008163:Luminescent Measurements / Q000379:methods; D057054:Molecular Imaging / Q000379:methods; D015336:Molecular Probe Techniques; D015335:Molecular Probes; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism*; D061848:Optical Imaging / Q000379:methods; D055503:Protein Multimerization
chemical_list: D014408:Biomarkers, Tumor; D005456:Fluorescent Dyes; D039302:Integrin alphaVbeta3; D015335:Molecular Probes; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid