title: Rheological behavior and Ibuprofen delivery applications of pH responsive composite alginate hydrogels.
abstract: Synthesis and structural characterization of hydrogels composed of sodium alginate, polyethylene oxide and acrylic acid with cyclodextrin as the hydrocolloid prepared at different pH values is presented. The hydrogels synthesized show significant variations in rheological properties, drug encapsulation capability and release kinetics. The hydrogels prepared at lower pH (pH 1) are more elastic, have high tensile strength and remain almost unaffected by varying temperature or frequency. Further, their Ibuprofen encapsulation capacity is low and releases it slowly. The hydrogel prepared at neutral pH (pH 7) is viscoelastic, thermo-reversible and also exhibits sol-gel transition on applying frequency and changing temperature. It shows highest Ibuprofen encapsulation capacity and also optimum drug release kinetics. The hydrogel prepared at higher pH (pH 12) is more viscous, has low tensile strength, is unstable to change in temperature and has fast drug release rate. The study highlights the pH responsiveness of three composite alginate hydrogels prepared under different conditions to be employed in drug delivery applications.
authors.affiliation: Department of Chemistry, University of Kashmir, Srinagar 190006, J&K, India.
authors.forename: Suraya
authors.initials: S
authors.lastname: Jabeen
authors.affiliation: Department of Chemistry, University of Kashmir, Srinagar 190006, J&K, India.
authors.forename: Masrat
authors.initials: M
authors.lastname: Maswal
authors.affiliation: Department of Chemistry, University of Kashmir, Srinagar 190006, J&K, India.
authors.forename: Oyais Ahmad
authors.initials: OA
authors.lastname: Chat
authors.affiliation: Department of Chemistry, University of Kashmir, Srinagar 190006, J&K, India. Electronic address: gmrather2002@yahoo.com.
authors.forename: Ghulam Mohammad
authors.initials: GM
authors.lastname: Rather
authors.affiliation: Department of Chemistry, University of Kashmir, Srinagar 190006, J&K, India. Electronic address: aijaz_n5@yahoo.co.in.
authors.forename: Aijaz Ahmad
authors.initials: AA
authors.lastname: Dar
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000464:Alginates / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D065546:Drug Liberation; D004548:Elasticity; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000737:chemistry*; D007700:Kinetics; D044367:Phase Transition; D011092:Polyethylene Glycols / Q000737:chemistry*; D012212:Rheology; D013696:Temperature; D013718:Tensile Strength; D014783:Viscosity
chemical_list: D000179:Acrylates; D000464:Alginates; D003505:Cyclodextrins; D004337:Drug Carriers; D006603:Hexuronic Acids; D020100:Hydrogels; D011092:Polyethylene Glycols; D020723:Glucuronic Acid; C036658:acrylic acid; D007052:Ibuprofen
keywords: Encapsulation capacity; Hydrogel; Sodium alginate; Swelling ratio