title: Organocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones witho-Formyl-β-nitrostyrenes.
abstract: A highly diastereo- and enantioselective domino Michael/Henry reaction of 1-acetylindolin-3-ones witho-formyl-(E)-β-nitrostyrenes catalyzed by low loading of a quinine-derived amine-squaramide provides the corresponding indolin-3-one derivatives bearing four adjacent stereogenic centers in good to high yields and with excellent stereoselectivities.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
authors.forename: Suruchi
authors.initials: S
authors.lastname: Mahajan
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Chauhan
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
authors.forename: Charles C J
authors.initials: CC
authors.lastname: Loh
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
authors.forename: Server
authors.initials: S
authors.lastname: Uzungelis
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Raabe
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Enders
keywords: domino reaction; indolin-3-one; organocatalysis; oxindole; squaramide