title: The Ongoing Controversy: Crystalloids Versus Colloids.
abstract: There is still much debate over the optimal fluid to use for resuscitation. Different studies have indicated either crystalloid or colloid is the ideal intravenous solution to administer, based on mortality or various physiological parameters. Older studies found differences between crystalloids and colloids. However, with the evolving science of fluid administration, more recent studies have shown no differences in patient outcomes. This review article will provide an overview of these substances and discuss the advantages, disadvantages, and implications for giving crystalloids and colloids in clinical practice.
authors.affiliation: University of Kansas School of Nursing, Kansas City, Kansas (Drs Pierce and Shen, and Ms Thimmesch). Janet D. Pierce, PhD, APRN, CCRN, FAAN, is the Christine A. Hartley Endowed Professor at the University of Kansas School of Nursing in Kansas City, Kansas. She has completed research related to hemorrhagic shock and reperfusion injury using various intravenous fluids. Qiuhua Shen, PhD, APRN, RN, is an assistant professor at the University of Kansas School of Nursing in Kansas City, Kansas. She collaborated with Dr. Pierce in investigating the effects of administering coenzyme Q10 with fluid resuscitation following hemorrhagic shock. Amanda Thimmesch, BA, is a research associate at the University of Kansas School of Nursing. Ms Thimmesch has worked with Dr. Pierce as a member of her research team, studying hemorrhagic shock and infusion of lactated Ringer's and other antioxidants.
authors.forename: Janet D
authors.initials: JD
authors.lastname: Pierce
authors.forename: Qiuhua
authors.initials: Q
authors.lastname: Shen
authors.forename: Amanda
authors.initials: A
authors.lastname: Thimmesch
mesh_terms: D003102:Colloids / Q000627:therapeutic use*; D000077324:Crystalloid Solutions; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000627:therapeutic use*; D009726:Nurses; D015532:Rehydration Solutions; D012151:Resuscitation
chemical_list: D003102:Colloids; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D015532:Rehydration Solutions