title: BioGRID: A Resource for Studying Biological Interactions in Yeast.
abstract: The Biological General Repository for Interaction Datasets (BioGRID) is a freely available public database that provides the biological and biomedical research communities with curated protein and genetic interaction data. Structured experimental evidence codes, an intuitive search interface, and visualization tools enable the discovery of individual gene, protein, or biological network function. BioGRID houses interaction data for the major model organism species--including yeast, nematode, fly, zebrafish, mouse, and human--with particular emphasis on the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe as pioneer eukaryotic models for network biology. BioGRID has achieved comprehensive curation coverage of the entire literature for these two major yeast models, which is actively maintained through monthly curation updates. As of September 2015, BioGRID houses approximately 335,400 biological interactions for budding yeast and approximately 67,800 interactions for fission yeast. BioGRID also supports an integrated posttranslational modification (PTM) viewer that incorporates more than 20,100 yeast phosphorylation sites curated through its sister database, the PhosphoGRID.
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Rose
authors.initials: R
authors.lastname: Oughtred
authors.affiliation: Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3C 3J7, Canada;
authors.forename: Andrew
authors.initials: A
authors.lastname: Chatr-aryamontri
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
authors.forename: Bobby-Joe
authors.initials: BJ
authors.lastname: Breitkreutz
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Christie S
authors.initials: CS
authors.lastname: Chang
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Rust
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Chandra L
authors.initials: CL
authors.lastname: Theesfeld
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Sven
authors.initials: S
authors.lastname: Heinicke
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
authors.forename: Ashton
authors.initials: A
authors.lastname: Breitkreutz
authors.affiliation: Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3C 3J7, Canada;
authors.forename: Daici
authors.initials: D
authors.lastname: Chen
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Jodi
authors.initials: J
authors.lastname: Hirschman
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
authors.forename: Nadine
authors.initials: N
authors.lastname: Kolas
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Michael S
authors.initials: MS
authors.lastname: Livstone
authors.affiliation: School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom.
authors.forename: Julie
authors.initials: J
authors.lastname: Nixon
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
authors.forename: Lara
authors.initials: L
authors.lastname: O'Donnell
authors.affiliation: School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Ramage
authors.affiliation: School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom.
authors.forename: Andrew
authors.initials: A
authors.lastname: Winter
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
authors.forename: Teresa
authors.initials: T
authors.lastname: Reguly
authors.affiliation: Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3C 3J7, Canada;
authors.forename: Adnane
authors.initials: A
authors.lastname: Sellam
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
authors.forename: Chris
authors.initials: C
authors.lastname: Stark
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
authors.forename: Lorrie
authors.initials: L
authors.lastname: Boucher
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Kara
authors.initials: K
authors.lastname: Dolinski
authors.affiliation: Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3C 3J7, Canada; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada; School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom.
authors.forename: Mike
authors.initials: M
authors.lastname: Tyers
mesh_terms: D000818:Animals; D030541:Databases, Genetic / Q000706:statistics & numerical data*; D053263:Gene Regulatory Networks; D006801:Humans; D025941:Protein Interaction Mapping; D012441:Saccharomyces cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
chemical_list: D029701:Saccharomyces cerevisiae Proteins