title: Repetitive trigeminal nociceptive stimulation in rats increases their susceptibility to cortical spreading depression.
abstract: We examined the ability of trigeminal nerve activation to induce cortical spreading depression in rats. Capsaicin was injected into the bilateral plantar or whisker pad for either 4 or 6 days in rats. The number and duration of cortical spreading depressions induced by potassium were significantly increased in animals injected with capsaicin in the bilateral whisker pad compared with animals injected in the bilateral plantar or in controls, while administration of a GABAA receptor agonist decreased these effects. Repetitive nociceptive stimulation of the trigeminal nerve lowers the threshold for the induction of cortical spreading depression by altering GABAergic neuronal activity.
authors.affiliation: Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Haruki
authors.initials: H
authors.lastname: Toriumi
authors.affiliation: Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address: shimizu-toshi@umin.ac.jp.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Shimizu
authors.affiliation: Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Taeko
authors.initials: T
authors.lastname: Ebine
authors.affiliation: Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Takizawa
authors.affiliation: Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kayama
authors.affiliation: Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Anri
authors.initials: A
authors.lastname: Koh
authors.affiliation: Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Shibata
authors.affiliation: Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D013181:Cortical Spreading Depression / Q000187:drug effects*; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology; D059225:Nociception; D017207:Rats, Sprague-Dawley; D014276:Trigeminal Nerve / Q000187:drug effects* / Q000502:physiology
chemical_list: D002211:Capsaicin
keywords: Capsaicin; Cortical spreading depression; GABA; Nociceptive stimulation; Trigeminal nerve