title: Translocation of microbes and changes of immunocytes in the gut of rapid- and slow-progressor Chinese rhesus macaques infected with SIVmac239.
abstract: Human/simian immunodeficiency virus (HIV/SIV) infection can cause severe depletion of CD4(+) T cells in both plasma and mucosa; it also results in damage to the gut mucosa barrier, which makes the condition more conducive to microbial translocation. In this study, we used SIV-infected Chinese rhesus macaques to quantify the extent of microbial translocation and the function of immune cells in the entire gastrointestinal tract and to compare their differences between rapid and slow progressors. The results showed that in the slow progressors, microbial products translocated considerably and deeply into the lamina propria of the gut; the tissue macrophages had no significant differences compared with the rapid progressors, but there was a slightly higher percentage of mucosal CD8(+) T cells and a large amount of extracellular microbial products in the lamina propria of the intestinal mucosa of the slow progressors. The data suggested that although microbial translocation increased markedly, the mucosal macrophages and CD8(+) T cells were insufficient to clear the infiltrated microbes in the slow progressors. Also, therapies aimed at suppressing the translocation of microbial products in the mucosa could help to delay the progression of SIV disease.
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.|Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Lin-Tao
authors.initials: LT
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.|Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
authors.forename: Ren-Rong
authors.initials: RR
authors.lastname: Tian
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.|School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China.
authors.forename: Hong-Yi
authors.initials: HY
authors.lastname: Zheng
authors.affiliation: The Pathology Department, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Pan
authors.affiliation: The Pathology Department, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Tuo
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
authors.forename: Hou-Jun
authors.initials: HJ
authors.lastname: Xia
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
authors.forename: Xue-Shan
authors.initials: XS
authors.lastname: Xia
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Pang
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D018450:Disease Progression; D000069196:Gastrointestinal Microbiome; D007413:Intestinal Mucosa / Q000166:cytology* / Q000276:immunology* / Q000382:microbiology / Q000473:pathology / Q000821:virology; D018655:Lymphocyte Count; D008253:Macaca mulatta; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D008297:Male; D010587:Phagocytosis / Q000276:immunology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D019562:Viral Load
keywords: lamina propria; microbial translocation; mucosa; simian immunodeficiency virus