title: Preparation of a novel chitosan-g-poly(acrylamide)/Zn nanocomposite hydrogel and its applications for controlled drug delivery of ofloxacin.
abstract: Chitosan-g-poly(acrylamide)/Zn (CPA-Zn) nanocomposite was synthesized using simple method in the presence of microwave radiations. CPA-Zn nanocomposite was characterized by various analytical techniques. CPA-Zn nanocomposite was used for controlled drug delivery of ofloxacin. The maximum drug release was 75% which was observed in acidic medium. The cumulative drug release and drug released kinetics of CPA-Zn was investigated. It was noticed that the drug release behavior depended upon the pH of medium as well as on the the nature of matrix. CPA-Zn nanocomposites were also studied for their antibacterial activity against E. coli bacteria.
authors.affiliation: School of Chemistry, Shoolini University of Biotechnology and Management Sciences, Solan, H.P, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Pathania
authors.affiliation: School of Chemistry, Shoolini University of Biotechnology and Management Sciences, Solan, H.P, India.
authors.forename: Divya
authors.initials: D
authors.lastname: Gupta
authors.affiliation: Department of Chemistry, National Institute of Technology, Jalandhar, 144011 Punjab, India.
authors.forename: N C
authors.initials: NC
authors.lastname: Kothiyal
authors.affiliation: School of Chemistry, Shoolini University of Biotechnology and Management Sciences, Solan, H.P, India. Electronic address: gaurav8777@gmail.com.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Sharma
authors.affiliation: Department of Chemistry, College of Science, Bld. #5, King Saud University, Riyadh, Saudi Arabia.
authors.forename: G E
authors.initials: GE
authors.lastname: Eldesoky
authors.affiliation: Department of Chemistry, College of Science, Bld. #5, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Mu
authors.initials: M
authors.lastname: Naushad
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D008826:Microbial Sensitivity Tests; D008962:Models, Theoretical; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D015242:Ofloxacin / Q000008:administration & dosage* / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D015032:Zinc / Q000737:chemistry*; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D048271:Chitosan; D004337:Drug Carriers; D015242:Ofloxacin; D015032:Zinc; D000099166:Polyacrylamides
keywords: Acrylamide; Antibacterial; Chitosan; Drug delivery; Nanocomposite; Ofloxacin