title: Experimental models of renal dysfunction in female rats. Functional and histological aspects after unilateral nephrectomy or ligation of right renal vein with kidney preservation.
abstract: OBJECTIVE
  To compare renal dysfunction after right nephrectomy and ligation of the right renal vein with preservation of kidney.
  
  
  METHODS
  Animals' weight, pH, density, protein in urine and histological samples of the kidneys were evaluated. Fifteen female rats (Wistar) were divided into three groups. In the control group, right renal vein dissections were performed. In the second group, the right nephrectomy was performed. In the third group, the right renal vein was ligated and the kidney was preserved. Urine samples were taken before, three and seven days after the procedure. On the seventh postoperative day the kidneys were removed to histopathological study. Analysis by Student's t test was performed.
  
  
  RESULTS
  weight loss, alterations of urine pH (p<0.05), in specific gravity, proteinuria (p<0.05) were found in groups 2 and 3; hemorrhagic infarction and edema were found after ligation of the right renal vein; changes in the left kidney were also observed on the seventh day.
authors.affiliation: Universidade Nove de Julho, Sao Paulo, SP, Brazil.
authors.forename: Ingrid Anita Colombo Wadih Schumann
authors.initials: IA
authors.lastname: Racanicchi
authors.affiliation: Universidade Nove de Julho, Sao Paulo, SP, Brazil.
authors.forename: Ana Beatriz Soares de
authors.initials: AB
authors.lastname: Oliveira
authors.affiliation: Laboratory of Experimental Research on Histology, UNINOVE, Sao Paulo, SP, Brazil.
authors.forename: Renato Lamounier
authors.initials: RL
authors.lastname: Barbieri
authors.affiliation: Laboratory of Experimental Research on Physiology, UNINOVE, Sao Paulo, SP, Brazil.
authors.forename: Humberto
authors.initials: H
authors.lastname: Dellê
authors.affiliation: Laboratory of Experimental Research on Surgery, UNINOVE, Sao Paulo, SP, Brazil.
authors.forename: Ivone da Silva
authors.initials: Ida S
authors.lastname: Duarte
authors.affiliation: Laboratory of Experimental Research on Surgery, UNINOVE, Sao Paulo, SP, Brazil.
authors.forename: Pedro Luiz Squilacci
authors.initials: PL
authors.lastname: Leme
mesh_terms: D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D005260:Female; D007668:Kidney / Q000473:pathology / Q000503:physiopathology*; D007674:Kidney Diseases / Q000209:etiology*; D008026:Ligation / Q000009:adverse effects; D009392:Nephrectomy / Q000009:adverse effects*; D019106:Postoperative Hemorrhage / Q000209:etiology*; D011507:Proteinuria / Q000652:urine; D017208:Rats, Wistar; D012082:Renal Veins