title: Geometry-independent assessment of renal volume in polycystic kidney disease from magnetic resonance imaging.
abstract: Total renal volume (TRV) is an important quantitative indicator of the progression of autosomal dominant polycystic kidney disease (ADPKD). The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease proposes a method for TRV computation based on manual tracing and geometric modeling. We developed a fast and nearly-automated technique for kidney segmentation and automatically compute TRV. In this study we aim to compare TRV estimates derived from these two different approaches. The highly-automated technique for the analysis of MR images was tested on 30 ADPKD patients. TRV was computed from both axial and coronal acquisitions, and compared to measurements based on geometric modeling by linear regression and Bland Altman analysis. In addition, to assess reproducibility, intra-observer and inter-observer variabilities were computed. The results of this study provide the feasibility of using a nearly-automated approach for accurate and fast evaluation of TRV also in markedly enlarged ADPKD kidneys.
authors.forename: Dario
authors.initials: D
authors.lastname: Turco
authors.forename: Stefano
authors.initials: S
authors.lastname: Severi
authors.forename: Renzo
authors.initials: R
authors.lastname: Mignani
authors.forename: Riccardo
authors.initials: R
authors.lastname: Magistroni
authors.forename: Cristiana
authors.initials: C
authors.lastname: Corsi
mesh_terms: D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007668:Kidney / Q000473:pathology*; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D008962:Models, Theoretical; D015588:Observer Variation; D010363:Pattern Recognition, Automated; D007690:Polycystic Kidney Diseases / Q000473:pathology*; D016891:Polycystic Kidney, Autosomal Dominant / Q000473:pathology*; D015203:Reproducibility of Results