title: Acute modification in plasma lipid levels in ultramarathon runners.
abstract: We aimed to evaluate the effects of a 24-h ultramarathon, an aerobic test of high physical load, on lipid profile and apolipoproteins B (ApoB) and A1 (ApoA1) levels, minimally modified low-density lipoprotein (LDL), and oxidised LDL. Prospective evaluation of 16 male athletes who participated in an ultramarathon run, where the objective was to run the greatest distance possible in 24 h. Fourteen participants completed the run. The mean distance achieved was 133.1 km (maximum of 169.6 km). There was a trend in reduction of triglycerides and total cholesterol (P = 0.06 and 0.05, respectively), without significant modifications in high-density lipoprotein, LDL and ApoA1 levels (P = 0.16; 0.55 and 0.67). There was a marked reduction in ApoB levels (P < 0.001), correlated directly to the distance covered (Pearson R = 0.68). Accordingly, an increase in the LDL/ApoB ratio was observed. The stress of this physical activity was not associated to an increase in minimally modified LDL or oxidised LDL. Lipid profile levels were not acutely altered by prolonged physical activity. Similarly, there was no evidence of greater oxidation of LDL over a 24-h period of physical activity. The reduction in ApoB was directly proportional to the distance covered, suggesting an acute positive change in phenotype of LDL molecules.
authors.affiliation: a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil.|b Hospital Cardiologico Costantini , Curitiba , PR , Brazil.
authors.forename: Luiz Gustavo Marin
authors.initials: LG
authors.lastname: Emed
authors.affiliation: a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil.
authors.forename: Daniela Gunther
authors.initials: DG
authors.lastname: Passaglia
authors.affiliation: a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil.
authors.forename: Surya T
authors.initials: ST
authors.lastname: Guerios
authors.affiliation: a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil.
authors.forename: Paula G D
authors.initials: PG
authors.lastname: João
authors.affiliation: a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil.
authors.forename: André I S
authors.initials: AI
authors.lastname: Moser
authors.affiliation: c Faculdade de Ciências Farmacêuticas , Universidade de São Paulo , São Paulo , Brazil.
authors.forename: Dulcinéia S P
authors.initials: DS
authors.lastname: Abdalla
authors.affiliation: a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil.|b Hospital Cardiologico Costantini , Curitiba , PR , Brazil.
authors.forename: Luis Cesar
authors.initials: LC
authors.lastname: Guarita-Souza
authors.affiliation: a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil.
authors.forename: Emanuella Stella
authors.initials: ES
authors.lastname: Mikilita
authors.affiliation: a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil.
authors.forename: Cristina Pellegrino
authors.initials: CP
authors.lastname: Baena
authors.affiliation: a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil.
authors.forename: Ana Beatriz Brenner Affonso
authors.initials: AB
authors.lastname: da Costa
authors.affiliation: a School of Medicine , Pontifícia Universidade Católica do Paraná, PUC-PR , Curitiba , PR , Brazil.
authors.forename: José Rocha
authors.initials: JR
authors.lastname: Faria-Neto
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010807:Physical Endurance / Q000502:physiology*; D012420:Running / Q000502:physiology*; D014280:Triglycerides / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D008055:Lipids; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol
keywords: Physical activity; lipoproteins; oxidised low density lipoprotein; physical endurance