title: Differentiation therapy: a promising strategy for cancer treatment.
abstract: Poor differentiation is an important hallmark of cancer cells, and differentiation therapy holds great promise for cancer treatment. The restoration of IkB kinase α (IKKα) leads to the differentiation of nasopharyngeal carcinoma cells with reduced tumorigenicity. The findings by Yan et al. validate the polycomb protein enhancer of zeste homologue 2 (EZH2) as a target for intervention.
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, Guangdong, P.R. China. yanmin@sysucc.org.cn.|Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, 116044, Dalian, Liaoning, P.R. China. yanmin@sysucc.org.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Yan
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, Guangdong, P.R. China. liuq9@mail.sysu.edu.cn.|Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, 116044, Dalian, Liaoning, P.R. China. liuq9@mail.sysu.edu.cn.
authors.forename: Quentin
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002277:Carcinoma; D002454:Cell Differentiation / Q000187:drug effects; D000071221:Enhancer of Zeste Homolog 2 Protein / Q000378:metabolism*; D044127:Epigenesis, Genetic / Q000187:drug effects; D006801:Humans; D051550:I-kappa B Kinase / Q000235:genetics* / Q000378:metabolism; D058990:Molecular Targeted Therapy; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; C498409:EZH2 protein, human; D000071221:Enhancer of Zeste Homolog 2 Protein; C496559:CHUK protein, human; D051550:I-kappa B Kinase