title: Endothelial dysfunction of vessels at lung cancer.
abstract: OBJECTIVE
  To evaluate changes in indicators of endothelial function and their relationship with morphological forms of disease, stage of pathological process and tumor markers, by analysis the peripheral blood of lung cancer (LC) patients.
  
  
  METHODS
  38 LC patients without metastases (mean age - 57 years) prior chemo- and radiotherapy were included in the study. The duration of the disease manifestation was 18 months. 21% of patients had small cell LC, and the rest - non-small cell LC. The ratio of patients with stages IA, IB, IIA, IIB, IIIA and IIIB LC was 1 : 3 : 3 : 4 : 4 : 4. The enzyme immunoassay, spectrophotometry, and statistical data analysis were used.
  
  
  RESULTS
  Endothelial dysfunction of vessels was characterized by increased blood levels of vascular endothelial growth factor (VEGF), endothelin-1 (ET1), homocysteine (HCys), cyclic guanosine monophosphate (cGMP), P-selectin (PSel) and nitrites (NO2) and simultaneously by decreased values of prostacyclin (PgI2). Those were observed in 100; 90; 76; 71; 50; 53 and 79% of LC cases, respectively. Disturbances of vascular endothelial function were associated with patient's age, disease duration, and morphological form and LC stage. Such changes were observed in women with higher prevalence. The studied indices correlated with tumor markers, namely transforming growth factor beta (TGFβ1), fibronectin and osteopontin.
  
  
  CONCLUSIONS
  Indices of vascular endothelial dysfunction in LC can be of diagnostic and prognostic value.
authors.affiliation: Maksim Gorky Donetsk National Medical University, Krasnyi Lyman 84400, Ukraine.
authors.forename: Y V
authors.initials: YV
authors.lastname: Dumanskiy
authors.affiliation: National Cancer Institute, Kyiv, 03022, Ukraine.
authors.forename: O Yu
authors.initials: OY
authors.lastname: Stoliarova
authors.affiliation: Maksim Gorky Donetsk National Medical University, Krasnyi Lyman 84400, Ukraine.
authors.forename: O V
authors.initials: OV
authors.lastname: Syniachenko
authors.affiliation: State Medical Academy, Dnipropetrovsk 49044, Ukraine.
authors.forename: E D
authors.initials: ED
authors.lastname: Iegudina
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A