title: Serum uric acid predicts cardiovascular mortality in male peritoneal dialysis patients with diabetes.
abstract: OBJECTIVE
  Serum uric acid may predict mortality in diabetic patients and dialysis patients. However, the relationship between serum uric acid and prognosis in diabetic peritoneal dialysis (PD) patients is unclear.
  
  
  RESULTS
  We conducted a cohort study of 1278 incident PD patients, (mean age 47.6 years), of which 328 (25.7%) had diabetes and 289 (22.6%) had diabetic nephropathy. During a median follow-up period of 30.7 months, 231 deaths occurred, of which 126 were ascribed to cardiovascular events. Mean serum uric acid was lower for diabetic patients than non-diabetic patients (6.8 ± 1.3 vs. 7.4 ± 1.4 mg/dL, respectively; P < 0.001). Cox regression models were adjusted for glycated hemoglobin, dialysis-related factors, traditional risk factors, and treatments. After adjustments, the highest sex-specific tertile of uric acid was associated with an increased risk of cardiovascular mortality (HR, 2.26; 95% CI, 1.14-4.48) compared to the lowest tertile in diabetic patients. Adjusted HRs per 1 mg/dL higher uric acid for all-cause and cardiovascular mortality were 1.09 (95% CI, 0.91-1.32) and 1.42 (95% CI, 1.13-1.79) for diabetic men and 1.06 (95% CI, 0.83-1.35) and 1.12 (95% CI, 0.78-1.61) for diabetic women, respectively. Elevated serum uric acid predicted a higher risk of all-cause and cardiovascular mortality in non-diabetic men but not in non-diabetic women.
  
  
  CONCLUSIONS
  Elevated serum uric acid is an independent predictor of cardiovascular mortality in diabetic male PD patients.
authors.affiliation: Department of Nephrology, Key Laboratory of Nephrology, Ministry of Health, Guangdong Provincial Key Laboratory of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: X
authors.initials: X
authors.lastname: Xia
authors.affiliation: Department of Nephrology, Key Laboratory of Nephrology, Ministry of Health, Guangdong Provincial Key Laboratory of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: C
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Nephrology, Key Laboratory of Nephrology, Ministry of Health, Guangdong Provincial Key Laboratory of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: F F
authors.initials: FF
authors.lastname: Peng
authors.affiliation: Department of Nephrology, Key Laboratory of Nephrology, Ministry of Health, Guangdong Provincial Key Laboratory of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Q M
authors.initials: QM
authors.lastname: Luo
authors.affiliation: Department of Nephrology, Key Laboratory of Nephrology, Ministry of Health, Guangdong Provincial Key Laboratory of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Department of Nephrology, Key Laboratory of Nephrology, Ministry of Health, Guangdong Provincial Key Laboratory of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Z C
authors.initials: ZC
authors.lastname: Lin
authors.affiliation: Department of Nephrology, Key Laboratory of Nephrology, Ministry of Health, Guangdong Provincial Key Laboratory of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: X Q
authors.initials: XQ
authors.lastname: Yu
authors.affiliation: Department of Nephrology, Key Laboratory of Nephrology, Ministry of Health, Guangdong Provincial Key Laboratory of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China. Electronic address: hfxyl@163.net.
authors.forename: F X
authors.initials: FX
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology / Q000401:mortality*; D002423:Cause of Death; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D003928:Diabetic Nephropathies / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000175:diagnosis / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010530:Peritoneal Dialysis / Q000009:adverse effects / Q000401:mortality*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid
keywords: Cardiovascular mortality; Diabetes; Peritoneal dialysis; Serum uric acid