title: Alzheimer disease, inflammation, and novel inflammatory marker: resistin.
abstract: Inflammation may play an important role in Alzheimer disease (AD) pathogenesis. A growing amount of evidence indicates that resistin has hallmark regulatory functions such as inflammatory states. The aim of this study was to determine whether plasma resistin levels would be useful in the diagnosis of patients with AD and to investigate the relationships between resistin and other inflammatory markers such as hs-CRP and TNF-α. Materials and methods: In this cross-sectional study, 38 AD patients and 32 control subjects with normal cognitive function aged 65 years and over were included. The diagnosis of AD was made according to DSM-IV and NINCDS-ADRDA criteria. Serum levels of resistin were measured with an enzyme-linked immunosorbent assay method using the human resistin E50 kit. Results: The median resistin level of AD patients was significantly higher than in the control group (86.3 vs. 70.8 pg/mL, P = 0.002). Overall accuracy of resistin in determining AD was 70.66%, with sensitivity, specificity, PPV, and NPV of 75.0%, 65.5%, 73.0%, and 67.9%, respectively. There was no statistically significant difference between AD patients and control subjects with respect to hs-CRP and TNF-α levels. Conclusion: Resistin levels may be considered as a predictor of AD and it may predict activation of the immune system in AD pathophysiology.
authors.forename: Muhammet Cemal
authors.initials: MC
authors.lastname: Kizilarslanoğlu
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Kara
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yeşil
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Kuyumcu
authors.forename: Zeynel Abidin
authors.initials: ZA
authors.lastname: Öztürk
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cankurtaran
authors.forename: Samed
authors.initials: S
authors.lastname: Rahatli
authors.forename: Nagehan
authors.initials: N
authors.lastname: Pakaştiçali
authors.forename: Esat
authors.initials: E
authors.lastname: Çinar
authors.forename: Meltem Gülhan
authors.initials: MG
authors.lastname: Halil
authors.forename: Burçin
authors.initials: B
authors.lastname: Sener
authors.forename: Eylem Sahin
authors.initials: ES
authors.lastname: Cankurtaran
authors.forename: Servet
authors.initials: S
authors.lastname: Arioğul
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D011237:Predictive Value of Tests; D012372:ROC Curve; D052243:Resistin / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; C499624:RETN protein, human; D052243:Resistin; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein