title: Validation of Ten Noninvasive Diagnostic Models for Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.
abstract: OBJECTIVE
  Noninvasive models have been developed for fibrosis assessment in patients with chronic hepatitis B. However, the sensitivity, specificity and diagnostic accuracy in evaluating liver fibrosis of these methods have not been validated and compared in the same group of patients. The aim of this study was to verify the diagnostic performance and reproducibility of ten reported noninvasive models in a large cohort of Asian CHB patients.
  
  
  METHODS
  The diagnostic performance of ten noninvasive models (HALF index, FibroScan, S index, Zeng model, Youyi model, Hui model, APAG, APRI, FIB-4 and FibroTest) was assessed against the liver histology by ROC curve analysis in CHB patients. The reproducibility of the ten models were evaluated by recalculating the diagnostic values at the given cut-off values defined by the original studies.
  
  
  RESULTS
  Six models (HALF index, FibroScan, Zeng model, Youyi model, S index and FibroTest) had AUROCs higher than 0.70 in predicting any fibrosis stage and 2 of them had best diagnostic performance with AUROCs to predict F≥2, F≥3 and F4 being 0.83, 0.89 and 0.89 for HALF index, 0.82, 0.87 and 0.87 for FibroScan, respectively. Four models (HALF index, FibroScan, Zeng model and Youyi model) showed good diagnostic values at given cut-offs.
  
  
  CONCLUSIONS
  HALF index, FibroScan, Zeng model, Youyi model, S index and FibroTest show a good diagnostic performance and all of them, except S index and FibroTest, have good reproducibility for evaluating liver fibrosis in CHB patients.
  
  
  BACKGROUND
  ChiCTR-DCS-07000039.
authors.affiliation: Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center of Digestive Diseases, Beijing, China.
authors.forename: Jieyao
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Hepatology Department, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Jinlin
authors.initials: J
authors.lastname: Hou
authors.affiliation: Gastroenterology and Hepatology Department, Beijing Youan Hospital, Capital Medical University, Beijing, China.
authors.forename: Huiguo
authors.initials: H
authors.lastname: Ding
authors.affiliation: Diagnosis and Treatment Center of Liver Fibrosis, 302 Hospital of the China, Beijing, China.
authors.forename: Guofeng
authors.initials: G
authors.lastname: Chen
authors.affiliation: Infectious Diseases Department, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xie
authors.affiliation: Infectious Diseases Department, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Gastroenterology Department, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Minde
authors.initials: M
authors.lastname: Zeng
authors.affiliation: Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center of Digestive Diseases, Beijing, China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Ou
authors.affiliation: Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center of Digestive Diseases, Beijing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ma
authors.affiliation: Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center of Digestive Diseases, Beijing, China.
authors.forename: Jidong
authors.initials: J
authors.lastname: Jia
mesh_terms: D000328:Adult; D001219:Aspartate Aminotransferases / Q000032:analysis; D001706:Biopsy / Q000379:methods; D054459:Elasticity Imaging Techniques / Q000379:methods; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000378:metabolism; D019694:Hepatitis B, Chronic / Q000175:diagnosis*; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000601:surgery; D008103:Liver Cirrhosis / Q000175:diagnosis*; D008297:Male; D015203:Reproducibility of Results
chemical_list: D006514:Hepatitis B Surface Antigens; D001219:Aspartate Aminotransferases