title: Prevalence of Obesity and Its Influence on Achievement of Cardiometabolic Therapeutic Goals in Chinese Type 2 Diabetes Patients: An Analysis of the Nationwide, Cross-Sectional 3B Study.
abstract: BACKGROUND
  There are few data on the prevalence of obesity and its influence on achieving blood glucose, blood pressure, and blood lipid (3B) goals in Chinese type 2 diabetes outpatients.
  
  
  METHODS
  Patient demographic data, anthropometric measurements, medications, and blood glucose and lipid profiles of 24,512 type 2 diabetes patients from a large, geographically diverse study (CCMR-3B) were analyzed. Using cut-points for body mass index (BMI) and waist circumference (WC) recommended by the Working Group on Obesity in China, overweight and obesity were defined as BMIs of 24-27.9 kg/m2 and ≥28.0 kg/m2. Central obesity was defined as a waist circumference ≥80 cm in women and ≥85 cm in men. The 3B therapeutic goals were HbA1c<7.0%, BP<140/90 mmHg and LDL-C<2.6 mmol/L.
  
  
  RESULTS
  Overall, 43.0% of type 2 diabetes patients were overweight and 16.7% were obese; 13.3% of overweight and and 10.1% of obese patients achieved all the 3B target goals. Overweight or obese patients were less likely to achieve 3B goals than those with normal BMIs. More than a half the overweight or obese patients (69.6%) were centrally obese. Patients with abdominal obesity were less likely to achieve cardiometabolic targets than those without abdominal obesity. In multivariate logistic regression analysis, female, higher BMI and waist circumference, smoking, drinking, sedentary lifestyle, and longer diabetes duration were significantly correlated with failure to achieve 3B control goals.
  
  
  CONCLUSIONS
  Obesity is highly prevalent and associated with poor 3B control in Chinese type 2 diabetes patients. In clinical practice, more attention and resources should focus on weight loss for such patients.
authors.affiliation: Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.|Peking University Diabetes Center, Beijing, China.
authors.forename: Xianghai
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.|Peking University Diabetes Center, Beijing, China.
authors.forename: Linong
authors.initials: L
authors.lastname: Ji
authors.affiliation: Department of Endocrinology & Metabolism, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Xingwu
authors.initials: X
authors.lastname: Ran
authors.affiliation: Department of Endocrinology & Metabolism, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
authors.forename: Benli
authors.initials: B
authors.lastname: Su
authors.affiliation: Department of Endocrinology, Xijing Hospital, Forth Military Medical University, Xi'an, China.
authors.forename: Qiuhe
authors.initials: Q
authors.lastname: Ji
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Changyu
authors.initials: C
authors.lastname: Pan
authors.affiliation: Department of Endocrinology and Metabolism, The Third Affiliated Hospital Sun Yat-sen University, Guangzhou, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Weng
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.
authors.forename: Changsheng
authors.initials: C
authors.lastname: Ma
authors.affiliation: Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Chuanming
authors.initials: C
authors.lastname: Hao
authors.affiliation: Vital Strategic Research Institute, Berwyn, Pennsylvania, United States of America.
authors.forename: Danyi
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Peking University People's Hospital, Beijing, China.
authors.forename: Dayi
authors.initials: D
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology; D044466:Asian People; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000453:epidemiology* / Q000378:metabolism; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000453:epidemiology*; D056128:Obesity, Abdominal / Q000097:blood / Q000453:epidemiology; D010045:Outpatients; D050177:Overweight / Q000097:blood / Q000453:epidemiology; D012307:Risk Factors; D057185:Sedentary Behavior; D012907:Smoking / Q000453:epidemiology; D013997:Time Factors; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D008055:Lipids