title: Glycine transporter2 inhibitors: Getting the balance right.
abstract: Neurotransmitter transporters are targets for a wide range of therapeutically useful drugs. This is because they have the capacity to selectively manipulate the dynamics of neurotransmitter concentrations and thereby enhance or diminish signalling through particular brain pathways. High affinity glycine transporters (GlyTs) regulate extracellular concentrations of glycine and provide novel therapeutic targets for neurological disorders.
authors.affiliation: Discipline of Pharmacology, School of Medical Sciences, Sydney Medical School, University of Sydney, Sydney, NSW, 2006, Australia. Electronic address: robert.vandenberg@sydney.edu.au.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Vandenberg
authors.affiliation: Discipline of Pharmacology, School of Medical Sciences, Sydney Medical School, University of Sydney, Sydney, NSW, 2006, Australia.
authors.forename: Shannon N
authors.initials: SN
authors.lastname: Mostyn
authors.affiliation: Discipline of Pharmacology, School of Medical Sciences, Sydney Medical School, University of Sydney, Sydney, NSW, 2006, Australia.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Carland
authors.affiliation: Discipline of Pharmacology, School of Medical Sciences, Sydney Medical School, University of Sydney, Sydney, NSW, 2006, Australia.
authors.forename: Renae M
authors.initials: RM
authors.lastname: Ryan
mesh_terms: D000818:Animals; D050487:Glycine Plasma Membrane Transport Proteins / Q000037:antagonists & inhibitors*; D006801:Humans; D009422:Nervous System Diseases / Q000188:drug therapy / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D050487:Glycine Plasma Membrane Transport Proteins; D018377:Neurotransmitter Agents
keywords: Glycine neurotransmission; Glycine transport; Glycine transport inhibitors; Pain