title: Differences in and correlations between cognitive abilities and brain volumes in healthy control, mild cognitive impairment, and Alzheimer disease groups.
abstract: The purpose of this study is to investigate differences in and correlations between cognitive abilities and brain volumes in healthy control (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) groups. The Korean Version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K), which is used to diagnose AD, was used to measure the cognitive abilities of the study subjects, and the volumes of typical brain components related to AD diagnosis-cerebrospinal fluid (CSF), gray matter (GM), and white matter (WM)-were acquired. Of the CERAD-K subtests, the Boston Naming Test distinguished significantly among the HC, MCI, and AD groups. GM and WM volumes differed significantly among the three groups. There was a significant positive correlation between Boston Naming Test scores and GM and WM volumes. In conclusion, the Boston Naming Test and GM and WM brain volumes differentiated the three tested groups accurately, and there were strong correlations between Boston Naming Test scores and GM and WM volumes. These results will help to establish a test method that differentiates the three groups accurately and is economically feasible.
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea.
authors.forename: Soon-Cheol
authors.initials: SC
authors.lastname: Chung
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea.
authors.forename: Mi-Hyun
authors.initials: MH
authors.lastname: Choi
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea.
authors.forename: Hyung-Sik
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea.
authors.forename: Jung-Chul
authors.initials: JC
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea.
authors.forename: Sung-Jun
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea.
authors.forename: Ul-Ho
authors.initials: UH
authors.lastname: Jeong
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea.
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Baek
authors.affiliation: Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea.
authors.forename: Seon-Young
authors.initials: SY
authors.lastname: Gim
authors.affiliation: Department of Radiology, School of Medicine, Konkuk University, Chungju, South Korea.
authors.forename: Young Chil
authors.initials: YC
authors.lastname: Choi
authors.affiliation: Department of Anatomy, School of Medicine, Konkuk University, Seoul, South Korea.
authors.forename: Beob-Yi
authors.initials: BY
authors.lastname: Lee
authors.affiliation: Department of Information & Communication Engineering, Dongguk University, Seoul, South Korea.
authors.forename: Dae-Woon
authors.initials: DW
authors.lastname: Lim
authors.affiliation: Department of Philosophical Counseling and Psychology, Dong-Eui University, Busan, South Korea.
authors.forename: Boseong
authors.initials: B
authors.lastname: Kim
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000473:pathology*; D001284:Atrophy; D001921:Brain / Q000033:anatomy & histology / Q000473:pathology*; D016022:Case-Control Studies; D003071:Cognition; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009929:Organ Size
keywords: Alzheimer's disease; brain volume; cognitive ability; mild cognitive impairment