title: Procoagulant control strategies for the human blood clotting process.
abstract: This paper describes the comparison between two drug control strategies to hemophilia A. To emulate blood clotting and the pathological condition of hemophilia, a mathematical model composed by 14 ordinary differential equations is considered. We adopt a variable structure non-linear PID approach and a Model Predictive Control in order to control the dosage of procoagulant factor used in the treatment of hemophiliac patient. The two control actions are sampled for a practical application. Finally, we discuss and compare the results of the two control approaches, introducing a suited control index (eINR).
authors.forename: Marco
authors.initials: M
authors.lastname: Laurino
authors.forename: Tommaso
authors.initials: T
authors.lastname: Menara
authors.forename: Alessandro
authors.initials: A
authors.lastname: Stella
authors.forename: Monica
authors.initials: M
authors.lastname: Betta
authors.forename: Alberto
authors.initials: A
authors.lastname: Landi
mesh_terms: D001777:Blood Coagulation; D006467:Hemophilia A; D006801:Humans; D008962:Models, Theoretical