title: [SMALL CELL CARCINOMA OF THE PROSTATE: A CASE REPORT OF RELATIVE LONG-TERM SURVIVAL].
abstract: Small cell carcinoma of the prostate (SCCP) is rare, and no standard treatment regimen has yet been established. The overall prognosis remains poor. We experienced a case who obtained relative long-term survival with two types of chemotherapy treatments. A 69-year-old man underwent combined androgen blockade (CAB) with a diagnosis of prostate adenocarcinoma (Gleason score = 5 + 3) that was staged T3bN1M1b (initial PSA = 352 ng/ml). Twenty-five months after hormonal therapy, the level of serum PSA had elapsed remain low, however, FDG-PET/CT revealed high value at the lymph node of para-aortic and pelvic lesion. The levels of serum NSE and Pro-GRP elevated, and a prostate re-biopsy revealed a small cell carcinoma. Therefore, he was treated with 12-cycles of combination chemotherapy consisting of etoposide and carboplatin. Then, disease has progressed, so he was changed to second line chemotherapy with amrubicin. He underwent 12-cycles chemotherapy with amrubicin, but he died of cancer 39 months after the initial treatment of SCCP.
authors.forename: Masaru
authors.initials: M
authors.lastname: Hirai
authors.forename: Tsuzumi
authors.initials: T
authors.lastname: Konishi
authors.forename: Kimitoshi
authors.initials: K
authors.lastname: Saito
authors.forename: Satoshi
authors.initials: S
authors.lastname: Washino
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Nokubi
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Miyagawa
mesh_terms: D000368:Aged; D018943:Anthracyclines / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000556:secondary; D005047:Etoposide / Q000008:administration & dosage; D017809:Fatal Outcome; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D018943:Anthracyclines; D000970:Antineoplastic Agents; D005047:Etoposide; C055866:amrubicin; D016190:Carboplatin