title: Comparative analysis of cerebrospinal fluid biomarkers in the differential diagnosis of neurodegenerative dementia.
abstract: The analysis of cerebrospinal fluid biomarkers gains importance in clinical routine and is effective in substantiating dementia diagnosis in the differential diagnostic context.
  
  
  
  We evaluated the levels of β-amyloid (Aβ) 42, Aβ40, tau, and P-tau in a large patient population subdivided into prion diseases, tauopathies, synucleinopathies, and controls. Diagnostic test evaluation was assessed by ROC area under the curve analysis.
  
  
  
  High tau levels were detected in sporadic Creutzfeldt-Jakob disease (sCJD) and high P-tau levels in Alzheimer's disease (AD) and sCJD. Aβ40 was lower exclusively in prionopathies, but low Aβ42 was detected in AD, sCJD, and Lewy body dementia. When disease groups were stratified according to the underlying proteinopathy, we detected disease-type specificities for all biomarkers. P-tau/tau, Aβ42/40, Aβ42/tau, and Aβ40/tau ratios proved valuable in discriminating disease groups and controls, especially P-tau/tau ratio in the identification of sCJD cases.
  
  
  
  Combining the biomarker panel allows differentiating between various types of neurodegenerative dementias and contributes to a better understanding of their pathophysiological processes.
authors.affiliation: Clinical Dementia Center, Department of Neurology, University Medical Center Göttingen, Göttingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany. Electronic address: franc.llorens@gmail.com.
authors.forename: Franc
authors.initials: F
authors.lastname: Llorens
authors.affiliation: Clinical Dementia Center, Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Schmitz
authors.affiliation: Department of Epidemiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
authors.forename: André
authors.initials: A
authors.lastname: Karch
authors.affiliation: Clinical Dementia Center, Department of Neurology, University Medical Center Göttingen, Göttingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Cramm
authors.affiliation: Clinical Dementia Center, Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Lange
authors.affiliation: Clinical Dementia Center, Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Kerim
authors.initials: K
authors.lastname: Gherib
authors.affiliation: Clinical Dementia Center, Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Varges
authors.affiliation: Clinical Dementia Center, Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Schmidt
authors.affiliation: Clinical Dementia Center, Department of Neurology, University Medical Center Göttingen, Göttingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
authors.forename: Inga
authors.initials: I
authors.lastname: Zerr
authors.affiliation: Clinical Dementia Center, Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Stoeck
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000503:physiopathology; D003937:Diagnosis, Differential; D006801:Humans; D020961:Lewy Body Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000503:physiopathology; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; D016875:tau Proteins
keywords: Biomarkers; Cerebrospinal fluid; Neurodegenerative dementias; Prionopathy; Synucleinopathy; Tauopathy