title: Metal-Free Three-Component Domino Approach to Phosphonylated Triazolines and Triazoles.
abstract: An efficient, three-component domino reaction between aldehydes, amines, and the Bestmann-Ohira reagent is reported that enables a general, mild, and straightforward access to 1,4,5-trisubstituted 1,2,3-triazolines and triazoles. The reaction proceeds through a domino-condensation/1,3-dipolar cycloaddition sequence to afford the triazoline derivatives with excellent diastereoselectivity. Moreover, when both amine and aldehyde employed for this reaction are aromatic, a spontaneous oxidation afforded 1,4,5-trisubstituted triazoles in moderate yields.
authors.affiliation: Academy of Scientific and Innovative Research , New Delhi 110001, India.
authors.forename: Shakir
authors.initials: S
authors.lastname: Ahamad
authors.forename: Ruchir
authors.initials: R
authors.lastname: Kant
authors.affiliation: Academy of Scientific and Innovative Research , New Delhi 110001, India.
authors.forename: Kishor
authors.initials: K
authors.lastname: Mohanan
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D061565:Cycloaddition Reaction; D015394:Molecular Structure; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000588:Amines; D014230:Triazoles