title: Radiation-induced undifferentiated pleomorphic sarcoma after radiation therapy for a desmoid tumour.
abstract: Radiation-induced sarcoma is a long-term complication of radiation therapy. The most common secondary neoplasia is the undifferentiated pleomorphic sarcoma, which is usually described in the deep soft tissue of the trunk or extremities. Radiation-induced sarcomas have a poor prognosis. An early diagnosis and management are needed to improve the survival rate of such patients. We presently report a case of a radiation-induced undifferentiated pleomorphic sarcoma of the left gluteus maximus muscle, which developed 25 years after an initial diagnosis of aggressive fibromatosis and 21 years after a tumour recurrence. This case study illustrates the risk of developing a sarcoma in a radiation field and the need for long-term follow-up after radiation therapy. Unnecessary radiation therapy, in particular in the case of benign conditions in young patients, should be avoided.
authors.affiliation: Department of rheumatology, hôpital Lariboisière, 2, rue Ambroise-Paré, 75010 Paris, France. Electronic address: julie_dimarco@hotmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Di Marco
authors.affiliation: Department of pathology, hôpital Lariboisière, 2, rue Ambroise-Paré, 75010 Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Kaci
authors.affiliation: Department of rheumatology, hôpital Lariboisière, 2, rue Ambroise-Paré, 75010 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Orcel
authors.affiliation: Department of orthopaedic surgery, hôpital Lariboisière, 2, rue Ambroise-Paré, 75010 Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Nizard
authors.affiliation: Department of radiology, hôpital Lariboisière, 2, rue Ambroise-Paré, 75010 Paris, France.
authors.forename: J-D
authors.initials: JD
authors.lastname: Laredo
mesh_terms: D002081:Buttocks; D005260:Female; D018222:Desmoid Tumors / Q000532:radiotherapy; D006801:Humans; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D012509:Sarcoma / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000532:radiotherapy
keywords: Aggressive fibromatosis; Radiation therapy; Radiation-induced sarcoma; Radiothérapie; Sarcome radio-induit; Sarcome à cellules pléomorphes; Soft tissue tumour; Tumeur des tissus mous; Tumeur desmoïde; Undifferentiated pleomorphic sarcoma