title: Ovaries are more vulnerable than hepatocytes for insulin resistance and hyperinsulinemia.
abstract: OBJECTIVE
  Non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) are common metabolic disorders. We aimed to evaluate the underlying mechanisms in the development of NAFLD and PCOS.
  
  
  METHODS
  Thirty female patients with NAFLD and without PCOS; 12 female patients with PCOS; and a control group with 17 healthy females were included. Pancreatic homeostatic model assessment-Beta cell function was measured by the homeostasis model assessment (HOMA)-B test.
  
  
  RESULTS
  The body mass index (BMI) of the NAFLD patients was higher than that of the PCOS patients (29.4±3.8 kg/m² vs 25.6±5.2 kg/m², p<0.05). There was no significant difference between the PCOS patients and controls with respect to BMI. The fasting insulin levels of the NAFLD patients were higher than those of the PCOS patients (5.06 unit more than PCOS, p<0.05) and 12.8 unit more than controls (p<0.001). The HOMA scores of the NAFLD patients were more than those of the PCOS patients (1.41 unit more than PCOS, p<0.05) and 2.95 unit more than controls (p<0.001). The HOMA-B score was higher in the NAFLD patients than in the PCOS patients. There was no statistical difference among the groups for serum triglyceride (p>.05) and cholesterol (p>.05).
  
  
  CONCLUSIONS
  This study showed that rather than pancreatic beta-cell hyperfunction, insulin resistance plays a central role in the development of ovarian abnormalities.
authors.affiliation: Department of Internal Medicine, Bezmialem Vakıf University Faculty of Medicine, İstanbul, Turkey. metin_basaranoglu@yahoo.com.
authors.forename: İlhami
authors.initials: İ
authors.lastname: Gültepe
authors.forename: Metin
authors.initials: M
authors.lastname: Başaranoğlu
authors.forename: Yaser
authors.initials: Y
authors.lastname: Süleymanoğlu
authors.forename: Gökçen
authors.initials: G
authors.lastname: Başaranoğlu
authors.forename: Fatma
authors.initials: F
authors.lastname: Beyazıt
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005215:Fasting / Q000097:blood; D005260:Female; D022781:Hepatocytes / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000378:metabolism; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D010053:Ovary / Q000503:physiopathology; D010179:Pancreas / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D014280:Triglycerides / Q000097:blood
chemical_list: D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol