title: Type VI secretion and anti-host effectors.
abstract: Secretion systems play a central role in infectious diseases by enabling pathogenic bacteria to deliver virulence factors into target cells. The type VI secretion system (T6SS) mediates bacterial antagonism in various environments including eukaryotic niches, such as the gut. This molecular machine injects lethal toxins directly in target bacterial cells. It provides an advantage to pathogens encountering the commensal flora of the host and indirectly contributes to colonization and persistence. Yet, the T6SS is not employed for the sole purpose of bacterial killing and several T6SS effectors are dedicated to the subversion of eukaryotic cells. As described for type III and type IV secretion systems, these effectors impede host cell functions and promote immune evasion, thereby enabling successful infection.
authors.affiliation: MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, SW72AZ London, United Kingdom; Department of Pathogen Molecular Biology, Faculty of Infection and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Victoria 3000, Australia.
authors.forename: Abderrahman
authors.initials: A
authors.lastname: Hachani
authors.affiliation: MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, SW72AZ London, United Kingdom.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Wood
authors.affiliation: MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, SW72AZ London, United Kingdom. Electronic address: a.filloux@imperial.ac.uk.
authors.forename: Alain
authors.initials: A
authors.lastname: Filloux
mesh_terms: D000818:Animals; D000898:Antibiosis; D001419:Bacteria / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000276:immunology / Q000382:microbiology*; D001426:Bacterial Proteins / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000382:microbiology; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D051379:Mice; D021381:Protein Transport; D013559:Symbiosis; D000069376:Type VI Secretion Systems / Q000235:genetics / Q000502:physiology*; D037521:Virulence Factors / Q000235:genetics / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D000069376:Type VI Secretion Systems; D037521:Virulence Factors