title: Influenza and pneumococcal vaccine coverage in 584 patients taking biological therapy for chronic inflammatory joint: A retrospective study.
abstract: OBJECTIVE
  To evaluate influenza and pneumococcal vaccine coverage in patients taking biological therapy for chronic inflammatory joint disease and to identify factors associated with the decision to administer these two vaccines.
  
  
  METHODS
  Retrospective cross-sectional questionnaire study of a cohort of 584 patients taking biological therapy for chronic inflammatory joint disease (rheumatoid arthritis or spondyloarthritis). We studied the influenza and pneumococcal vaccine coverage rates, information about these vaccines given to patients by the primary-care physician and rheumatologist, and reasons for not administering the vaccines.
  
  
  RESULTS
  Overall vaccine coverage rates were 44% for influenza and 62% for pneumococcus. Factors associated with being vaccinated were patient age, previous influenza vaccination, and patient information. Concern about adverse effects and absence of patient information by the primary-care physician and rheumatologist were associated with very low coverage rates.
  
  
  CONCLUSIONS
  This study showed insufficient vaccine coverage rates, particularly against influenza, in a population at high risk because of exposure to biological therapy. Patient information by healthcare professionals about influenza and pneumococcal vaccination has a major impact and should be renewed as often as possible.
authors.affiliation: Rhumatologie, centre hospitalier Princesse Grâce, boulevard Pasteur, 98000 Monaco, Monaco. Electronic address: obrocq@chpg.mc.
authors.forename: Olivier
authors.initials: O
authors.lastname: Brocq
authors.affiliation: Service de rhumatologie, hôpital Archet 1, université de Nice, 06200 Nice, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Acquacalda
authors.affiliation: Département d'information médicale, CHPG, 98000 Monaco, Monaco.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Berthier
authors.affiliation: Service de rhumatologie, hôpital Archet 1, université de Nice, 06200 Nice, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Albert
authors.affiliation: Service de rhumatologie, centre hospitalier de Cannes, 06400 Cannes, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Bolla
authors.affiliation: Service de rhumatologie, centre hospitalier Fréjus-Saint-Raphaël, 83800 Saint-Raphaël, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Millasseau
authors.affiliation: Service de rhumatologie, centre hospitalier Fréjus-Saint-Raphaël, 83800 Saint-Raphaël, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Destombe
authors.affiliation: Service de rhumatologie, centre hospitalier de Cannes, 06400 Cannes, France.
authors.forename: Johanna
authors.initials: J
authors.lastname: Azulay
authors.affiliation: Service de rhumatologie, centre hospitalier de Cannes, 06400 Cannes, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Asquier
authors.affiliation: Service de rhumatologie, hôpital Archet 1, université de Nice, 06200 Nice, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Florent
authors.affiliation: Service de rhumatologie, centre hospitalier Fréjus-Saint-Raphaël, 83800 Saint-Raphaël, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Le Seaux
authors.affiliation: Service de rhumatologie, hôpital Archet 1, université de Nice, 06200 Nice, France.
authors.forename: Liana
authors.initials: L
authors.lastname: Euller-Ziegler
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy; D001691:Biological Therapy / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000209:etiology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000209:etiology / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D012189:Retrospective Studies; D025241:Spondylarthritis / Q000150:complications* / Q000188:drug therapy; D011795:Surveys and Questionnaires
chemical_list: D007252:Influenza Vaccines; D022242:Pneumococcal Vaccines
keywords: Biological therapy; Chronic inflammatory joint disease; Influenza vaccination; Pneumococcal vaccination