title: The Link Between Inflammatory Disorders and Coronary Heart Disease: a Look at Recent Studies and Novel Drugs in Development.
abstract: Inflammation is a critical component in the development of coronary heart disease (CHD), specifically in the process of atherogenesis. Human translational and preclinical studies have demonstrated that inflammation contributes to the development, sustainment, and progression of atherosclerosis, and epidemiological studies demonstrate that human diseases associated with increased systemic inflammation increase the risk of CHD-related events. Therefore, over the last decade, multiple clinical studies were designed to target the inflammatory cascade in order to reduce the risk of CHD and to identify which populations may benefit from these preventative treatment strategies. This review briefly summarizes inflammation as a risk factor in atherosclerosis, human disease states associated with accelerated atherosclerosis, and current treatment strategies for CHD targeting the inflammatory cascade.
authors.affiliation: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: H
authors.initials: H
authors.lastname: Teague
authors.affiliation: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. nehal.mehta@nih.gov.|Cardiovascular and Pulmonary Branch, NHLBI, National Institutes of Health, 10 Center Drive, CRC, Room 5-5140, Bethesda, MD, 20892, USA. nehal.mehta@nih.gov.
authors.forename: Nehal N
authors.initials: NN
authors.lastname: Mehta
mesh_terms: D050197:Atherosclerosis / Q000150:complications; D003324:Coronary Artery Disease / Q000150:complications* / Q000188:drug therapy*; D018450:Disease Progression; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000150:complications; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Atherosclerosis; Coronary heart disease; Inflammation; Psoriasis; Rheumatoid arthritis; Systemic lupus erythematosus