title: Desynchronization of stochastically synchronized chemical oscillators.
abstract: Experimental and theoretical studies are presented on the design of perturbations that enhance desynchronization in populations of oscillators that are synchronized by periodic entrainment. A phase reduction approach is used to determine optimal perturbation timing based upon experimentally measured phase response curves. The effectiveness of the perturbation waveforms is tested experimentally in populations of periodically and stochastically synchronized chemical oscillators. The relevance of the approach to therapeutic methods for disrupting phase coherence in groups of stochastically synchronized neuronal oscillators is discussed.
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506-6045, USA.
authors.forename: Razan
authors.initials: R
authors.lastname: Snari
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506-6045, USA.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Tinsley
authors.affiliation: Department of Mechanical Engineering, University of California, Santa Barbara, California 93106, USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Wilson
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506-6045, USA.
authors.forename: Sadegh
authors.initials: S
authors.lastname: Faramarzi
authors.affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: Theoden Ivan
authors.initials: TI
authors.lastname: Netoff
authors.affiliation: Department of Mechanical Engineering, University of California, Santa Barbara, California 93106, USA.
authors.forename: Jeff
authors.initials: J
authors.lastname: Moehlis
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506-6045, USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Showalter
mesh_terms: D008962:Models, Theoretical; D012815:Signal Processing, Computer-Assisted; D013269:Stochastic Processes