title: [Controlled study of gadobenate dimeglumine versus gadopentetate in breast tumor MR dynamic enhancement scanning].
abstract: OBJECTIVE
  To compare the differences in diagnosing breast lesions between gadobenate (Gd-DTPA) and gadopentetate dimeglumine (Gd-BOPTA) in MR dynamic enhancement scanning.
  
  
  METHODS
  Continuous collection patients because of breast lesions from General Hospital of Lanzhou Command PLA in August 2012 to December 2014. Fifty-three women with breast lesions detected by clinical touch or by X-ray mammography and ultrasound examination were included. The patients were randomly injected with equivalent dose of Gd-BOPTA or Gd-DTPA. Two dynamic enhanced scanning were performed on the 3.0 T MR scanner separated by 48 to 72 hours and eight phases were collected 25 seconds after the injection. Analysis was done double-blinded to find out the lesions, make differential diagnosis, and to compare with the histopathology.
  
  
  RESULTS
  Among the 87 lesions diagnosed by postoperative pathological detection, more lesions were detected by Gd-BOPTA than by Gd-DTPA, 83/87 (95.4%) vs 69/87 (79.3%) (P < 0.01), respectively, the difference is statistically significant. In the detection of malignant lesions, the sensitivity was 96.3% and 76.3%, and the specificity was 78.1% and 68.7%, for Gd-BOPTA and Gd-DTPA, respectively.
  
  
  CONCLUSIONS
  Gd-BOPTA was better for the detection of breast lesions and differential diagnosis of benign and malignant lesions than Gd-DTPA. Especially, Gd-BOPTA is obviously better than Gd-DTPA in detection of breast nodules, and the lesions with weak strengthening effect or located inconspicuously.
authors.affiliation: Department of Radiology, the First Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Yang
authors.forename: Guangyao
authors.initials: G
authors.lastname: Liu
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Yu
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Email: cjr.guoyoumin@vip.163.com.
authors.forename: Youmin
authors.initials: Y
authors.lastname: Guo
mesh_terms: D001940:Breast; D001943:Breast Neoplasms; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography; D008536:Meglumine / Q000031:analogs & derivatives; D009942:Organometallic Compounds; D011184:Postoperative Period
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D019786:Gadolinium DTPA