title: Age-related macular degeneration and Alzheimer disease.
abstract: This review highlight the similarities in the pathogenesis between Alzheimer disease and age-related macular degeneration. All studies published between 1990 and 2014 were reviewed to identify the common pathological pathways. Alzheimer disease and age-related macular degeneration share common features such as vitronectin and amyloid-β accumulation, increased oxidative stress, and apolipoprotein and complement activation pathways, which are reviewed as histologic and immunologic common features.
authors.forename: Eren
authors.initials: E
authors.lastname: Çerman
authors.forename: Muhsin
authors.initials: M
authors.lastname: Eraslan
authors.forename: Osman
authors.initials: O
authors.lastname: Çekiç
mesh_terms: D000367:Age Factors; D000544:Alzheimer Disease / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000502:physiology; D001053:Apolipoproteins / Q000502:physiology; D003167:Complement Activation; D006801:Humans; D008268:Macular Degeneration / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology; D019096:Vitronectin / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides; D001053:Apolipoproteins; D019096:Vitronectin