title: Estimation of oxidative stress parameters in rats after simultaneous administration of rosuvastatin with antidepressants.
abstract: BACKGROUND
  Patients commonly receive statin drugs for the primary or secondary prevention of cardiovascular events and also commonly receive antidepressant drugs for the treatment of depression. A many-year polypharmacotherapy can lead to increased side effects of these drugs. It may lead to an oxidation-reduction imbalance and the growth of a generation of reactive oxygen species (ROS) which may induce cellular dysfunctions.
  
  
  METHODS
  The aim of this study was to assess oxidative stress parameters in the blood of rats after simultaneous administration of rosuvastatin (10mg/kg) with paroxetine (10mg/kg) or citalopram (10mg/kg). The activity of glutathione peroxidase (GPX) was determined in whole blood, and the activity of glutathione reductase (GR) and the total antioxidant status (TAS) were determined in the serum.
  
  
  RESULTS
  The 14-day simultaneous administration of rosuvastatin with paroxetine or citalopram caused an increase in glutathione peroxidase and glutathione reductase activity and did not influence the level of the total antioxidant status. Rosuvastatin (10mg/kg) or citalopram (10mg/kg) administered alone to rats for 14 days did not affect the examined parameters. The 14-day application of paroxetine (10mg/kg) significantly decreased a glutathione peroxidase activity, increased a glutathione reductase activity and did not affect the level of TAS.
  
  
  CONCLUSIONS
  The observed changes may indicate an increased activity of the enzyme system preventing oxidation, which appears to be the effect of the reaction on the severity of oxidative stress during the combined treatment with rosuvastatin and antidepressants.
authors.affiliation: Chair and Department of Toxicology, Medical University of Lublin, Lublin, Poland. Electronic address: mariola.herbet@umlub.pl.
authors.forename: Mariola
authors.initials: M
authors.lastname: Herbet
authors.affiliation: Chair and Department of Toxicology, Medical University of Lublin, Lublin, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Izdebska
authors.affiliation: Chair and Department of Toxicology, Medical University of Lublin, Lublin, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Piątkowska-Chmiel
authors.affiliation: Chair and Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Poleszak
authors.affiliation: Chair and Department of Toxicology, Medical University of Lublin, Lublin, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Jagiełło-Wójtowicz
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D000068718:Rosuvastatin Calcium / Q000008:administration & dosage*
chemical_list: D000928:Antidepressive Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017382:Reactive Oxygen Species; D000068718:Rosuvastatin Calcium; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase
keywords: Citalopram; Oxidative stress parameters; Paroxetine; Rat; Rosuvastatin