title: Boronic acids for fluorescence imaging of carbohydrates.
abstract: "Fluorescence imaging" is a particularly exciting and rapidly developing area of research; the annual number of publications in the area has increased ten-fold over the last decade. The rapid increase of interest in fluorescence imaging will necessitate the development of an increasing number of molecular receptors and binding agents in order to meet the demand in this rapidly expanding area. Carbohydrate biomarkers are particularly important targets for fluorescence imaging given their pivotal role in numerous important biological events, including the development and progression of many diseases. Therefore, the development of new fluorescent receptors and binding agents for carbohydrates is and will be increasing in demand. This review highlights the development of fluorescence imaging agents based on boronic acids a particularly promising class of receptors given their strong and selective binding with carbohydrates in aqueous media.
authors.affiliation: Department of Chemistry, University of Bath, Bath, BA2 7AY, UK. t.d.james@bath.ac.uk.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Sun
authors.forename: Wenlei
authors.initials: W
authors.lastname: Zhai
authors.forename: John S
authors.initials: JS
authors.lastname: Fossey
authors.forename: Tony D
authors.initials: TD
authors.lastname: James
mesh_terms: D000818:Animals; D001897:Boronic Acids / Q000737:chemistry*; D019556:COS Cells; D002241:Carbohydrates / Q000737:chemistry*; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D056945:Hep G2 Cells; D006801:Humans; D051379:Mice; D061848:Optical Imaging; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D001897:Boronic Acids; D002241:Carbohydrates