title: Successful combination chemotherapy for metastatic inflammatory myofibroblastic tumor: A case report.
abstract: A 64-year-old male presented with increased abdo-minal fullness and fever. Radiological examination revealed moderate ascites, a tumor with a diameter of 12.5 cm in the mesenteric region, as well as multiple tumors in the thoracic and abdominal para-aortic regions and in the left supraclavicular regions. Pathohistological findings of the biopsy specimen revealed atypical spindle cells accompanied by infiltration of lymphocytes. The plasmacytes were positive for CD68, murine double minute 2 and S-100, while they were negative for α-smooth muscle actin, cyclin-dependent kinase 4 and anaplastic lymphoma kinase. Clinically, the patient presented systemic symptoms and laboratory results indicated an elevation in the inflammatory response, while the CT and MRI findings were consistent with an inflammatory myofibroblastic tumor (IMT). Based on the clinical and histological findings, the patient was diagnosed with IMT. In total, 4 cycles of combination chemotherapy with doxorubicin and ifosfamide were administered. Tumor size reduction by 50% was achieved subsequent to the 4th chemotherapy cycle. In conclusion, successful control of this rare metastatic IMT was achieved by systemic chemotherapy.
authors.affiliation: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Inadomi
authors.affiliation: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Hozumi
authors.initials: H
authors.lastname: Kumagai
authors.affiliation: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Kotoe
authors.initials: K
authors.lastname: Takayoshi
authors.affiliation: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ariyama
authors.affiliation: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kusaba
authors.affiliation: Department of Clinical Radiology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nishie
authors.affiliation: Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Yamamoto
authors.affiliation: Department of Hematology, National Hospital Organization Kyushu Medical Center, Fukuoka 810-0065, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Takase
authors.affiliation: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Sagara
authors.affiliation: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Okumura
authors.affiliation: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Nio
authors.affiliation: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Michitaka
authors.initials: M
authors.lastname: Nakano
authors.affiliation: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Arita
authors.affiliation: Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Oda
authors.affiliation: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812-8582, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Akashi
authors.affiliation: Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors.forename: Eishi
authors.initials: E
authors.lastname: Baba
keywords: anaplastic lymphoma kinase rearrangement negative; chemotherapy; inflammatory pseudotumor; metastatic inflammatory myofibroblastic tumor