title: Synthesis of bi- and bis-1,2,3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistry.
abstract: The Cu(I)-catalyzed azide-alkyne cycloaddition reaction, also known as click chemistry, has become a useful tool for the facile formation of 1,2,3-triazoles. Specifically, the utility of this reaction has been demonstrated by the synthesis of structurally diverse bi- and bis-1,2,3-triazoles. The present review focuses on the synthesis of such bi- and bistriazoles and the importance of using copper-promoted click chemistry (CuAAC) for such transformations. In addition, the application of bitriazoles and the related CuAAAC reaction in different fields, including medicinal chemistry, coordination chemistry, biochemistry, and supramolecular chemistry, have been highlighted.
authors.affiliation: Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, and College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310012, P. R. China.
authors.forename: Zhan-Jiang
authors.initials: ZJ
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, and College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310012, P. R. China.
authors.forename: Ding
authors.initials: D
authors.lastname: Wang
authors.affiliation: Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, and College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310012, P. R. China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, and College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310012, P. R. China; State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P. R. China.
authors.forename: Li-Wen
authors.initials: LW
authors.lastname: Xu
keywords: bistriazoles; click chemistry; cycloaddition; homogeneous catalysis; oxidative coupling