title: [Subjective cognitive impairment and Alzheimer's disease: a two year follow up of 51 subjects during two years].
abstract: Subjective cognitive impairment (SCI) is defined by a state of subjective complaint, without objective cognitive deterioration. Amnestic mild cognitive impairment (A-MCI), which characterizes a syndrome between normal cognitive aging and early Alzheimer's disease (E-AD), is preceded by A-MCI from many years. SCI expresses a metacognitive impairment. A cohort of 51 subjects [7 normal controls (NC), 28 SCI, 12 A-MCI and 5 E-AD] was followed up during 24 months, with a neuropsychological evaluation each 6 months during 1 year (V1, V2, V3), then 1 year later (V4). Among the 28 SCI, 6 converted to A-MCI at V4 (21.42%), 1 to A-MCI-A at V3, then to E-AD at V4. These results suggest a continuum from SCI to A-MCI, and E-AD. Progressive SCI differed from non-progressive SCI on verbal episodic memory and executive functions tests at the initial examination. MRI showed anterior cingular atrophy in all SCI patients but hippocampal atrophy was only observed in 20 patients. Our results suggest that metacognition impairment is the expression of a dysfunction in the anterior pre-frontal cortex, in correlation with a syndrome of hyper-attention.
authors.affiliation: Service de neurologie comportementale, Hôpital Sainte Marguerite, Marseille, France, CNRS LNIA UMR 7260 FR3C FR 3512, Aix-Marseille Université, Marseille, France, Groupe de recherche sur la maladie d'Alzheimer, Campus Santé Timone, Marseille, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Sambuchi
authors.affiliation: Service de neurologie comportementale, Hôpital Sainte Marguerite, Marseille, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Muraccioli
authors.affiliation: CNRS LNIA UMR 7260 FR3C FR 3512, Aix-Marseille Université, Marseille, France, Groupe de recherche sur la maladie d'Alzheimer, Campus Santé Timone, Marseille, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Alescio-Lautier
authors.affiliation: CNRS LNIA UMR 7260 FR3C FR 3512, Aix-Marseille Université, Marseille, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Paban
authors.affiliation: Laboratoire de santé publique, Faculté de médecine, Marseille, France.
authors.forename: Roland
authors.initials: R
authors.lastname: Sambuc
authors.affiliation: Laboratoire de santé publique, Faculté de médecine, Marseille, France.
authors.forename: Élisabeth
authors.initials: É
authors.lastname: Jouve
authors.affiliation: Alzheimer's disease research center Mayo-Clinic, Rochester Minnesota, États-Unis, Groupe de recherche sur la maladie d'Alzheimer, Campus Santé Timone, Marseille, France.
authors.forename: Yonas Endale
authors.initials: YE
authors.lastname: Geda
authors.affiliation: Alzheimer's disease research center Mayo-Clinic, Rochester Minnesota, États-Unis.
authors.forename: Ronald Karl
authors.initials: RK
authors.lastname: Petersen
authors.affiliation: Service de neurologie comportementale, Hôpital Sainte Marguerite, Marseille, France, CNRS LNIA UMR 7260 FR3C FR 3512, Aix-Marseille Université, Marseille, France, Alzheimer's disease research center Mayo-Clinic, Rochester Minnesota, États-Unis, Groupe de recherche sur la maladie d'Alzheimer, Campus Santé Timone, Marseille, France.
authors.forename: Bernard François
authors.initials: BF
authors.lastname: Michel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000523:psychology*; D003072:Cognition Disorders / Q000523:psychology*; D060825:Cognitive Dysfunction / Q000523:psychology*; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
keywords: Alzheimer's disease; amnestic mild cognitive impairment; anterior cingular cortex; memory complaint; metacognition; subjective cognitive impairment