title: Intranasal inoculation of sows with highly pathogenic porcine reproductive and respiratory syndrome virus at mid-gestation causes transplacental infection of fetuses.
abstract: Transplacental infection plays a critical role in the reproductive failure induced by porcine reproductive and respiratory syndrome virus (PRRSV), yet exposure of sows and gilts to classical PRRSV generally leads to reproductive failure after 85 days of gestation. We report, for the first time, that the susceptibility of fetuses to highly pathogenic PRRSV (HP-PRRSV) is similar at 60 days and 90 days of gestation. This difference from classical PRRSV may contribute to its high pathogenicity. A field study of the HP-PRRSV vaccine in pregnant sows at mid-gestation should be considered.
authors.affiliation: Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Veterinary Medicine, Shandong Agricultural University, Taian City, Shandong, China. wangtong.1021@163.com.
authors.forename: Tongtong
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Veterinary Medicine, Shandong Agricultural University, Taian City, Shandong, China. wxf19890908@126.com.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Veterinary Medicine, Shandong Agricultural University, Taian City, Shandong, China. xinan.1987@163.com.
authors.forename: Xin-An
authors.initials: XA
authors.lastname: Li
authors.affiliation: Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Veterinary Medicine, Shandong Agricultural University, Taian City, Shandong, China. nieli1221@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Nie
authors.affiliation: Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Veterinary Medicine, Shandong Agricultural University, Taian City, Shandong, China. 474659627@qq.com.
authors.forename: Minxia
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Veterinary Medicine, Shandong Agricultural University, Taian City, Shandong, China. liusid@sdau.edu.cn.
authors.forename: Sidang
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Veterinary Medicine, Shandong Agricultural University, Taian City, Shandong, China. xmzhao66@sdau.edu.cn.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Institute for Immunology and School of Medicine, Tsinghua University, Beijing, China. yinglish@126.com.
authors.forename: Yingli
authors.initials: Y
authors.lastname: Shang
authors.affiliation: College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China. zhouem@nwsuaf.edu.cn.
authors.forename: En-Min
authors.initials: EM
authors.lastname: Zhou
authors.affiliation: Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK. Julian.Hiscox@liverpool.ac.uk.
authors.forename: Julian A
authors.initials: JA
authors.lastname: Hiscox
authors.affiliation: Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Veterinary Medicine, Shandong Agricultural University, Taian City, Shandong, China. xiaoyihong01@163.com.
authors.forename: Yihong
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D000818:Animals; D005260:Female; D005333:Fetus / Q000821:virology; D008431:Maternal-Fetal Exchange; D019318:Porcine Reproductive and Respiratory Syndrome / Q000635:transmission*; D019316:Porcine respiratory and reproductive syndrome virus / Q000235:genetics / Q000502:physiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000662:veterinary* / Q000821:virology; D013552:Swine