title: [Temporal variation of serum interleukin-37 and its relation with C-reactive protein in patients with acute ST-segment elevation myocardial infarction].
abstract: OBJECTIVE
  To investigate the temporal changes of serum interleukin-37 (IL-37) concentration following acute ST-segment elevation myocardial infarction (ASTEMI) and the relationship between IL-37 and C-reactive protein (CRP) in patients with ASTEMI.
  
  
  METHODS
  This analysis was conducted in a cohort of 20 patients with an established diagnosis of ASTEMI and 26 patients admitted for chest pain but with normal findings in coronary angiography (control) between June 2012 and December 2013. Venous blood was collected at days 1, 3, 5, and 7 after myocardial infarction for measurement of serum IL-37 and CRP levels using enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Compared with the control group, the patients in ASTEMI group showed a significant acute elevation of IL-37 level on day 1 following myocardial infarction; IL-37 level reached the peak on day 3 and began to decrease on day 5, followed by a significant decrease on day 7. The time course of post-infarction CRP changes was consistent with that of IL-37 variations and showed a positive correlation the latter (r=0.63, P<0.05).
  
  
  CONCLUSIONS
  IL-37 may participate in the inflammatory responses in ASTEMI.
authors.affiliation: Department of Cardiology, Guangzhou Nansha Central Hospital, Guangzhou 511457, China. E-mail: henvqin@126.com.
authors.forename: Nvqin
authors.initials: N
authors.lastname: He
authors.forename: Shuxin
authors.initials: S
authors.lastname: Shen
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Shengcun
authors.initials: S
authors.lastname: Guo
authors.forename: Junfen
authors.initials: J
authors.lastname: Wang
authors.forename: Jianping
authors.initials: J
authors.lastname: Bin
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D017023:Coronary Angiography; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D009203:Myocardial Infarction / Q000097:blood*
chemical_list: C508587:IL37 protein, human; D007375:Interleukin-1; D002097:C-Reactive Protein