title: Oxidative stress, d-ROMs test, and ceruloplasmin.
abstract: Human serum samples were evaluated for oxidative stress with the d-ROMs test. The ceruloplasmin (CP) and copper contents of the samples was independently measured and compared to those calculated on the basis of the d-ROMs test results for pure CP solutions. The d-ROMs readings did not show any significant correlation with either the CP or copper contents of the samples. Critical interference of CP on the d-ROMs test was therefore excluded and the usefulness of the test in the evaluation of global oxidative status of a biological sample could be reassessed.
authors.affiliation: a Diacron International s.r.l. , Grosseto , Italy ;
authors.forename: Francesco
authors.initials: F
authors.lastname: Colombini
authors.affiliation: a Diacron International s.r.l. , Grosseto , Italy ;
authors.forename: Mauro
authors.initials: M
authors.lastname: Carratelli
authors.affiliation: b ISOF-CNR , Bologna , Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Alberti
mesh_terms: D001681:Biological Assay / Q000592:standards*; D002570:Ceruloplasmin / Q000737:chemistry* / Q000378:metabolism; D003300:Copper / Q000097:blood / Q000737:chemistry*; D006801:Humans; D007501:Iron / Q000097:blood / Q000737:chemistry; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010655:Phenylenediamines / Q000097:blood / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000097:blood / Q000737:chemistry*
chemical_list: D010655:Phenylenediamines; D017382:Reactive Oxygen Species; D003300:Copper; C013935:N,N-diethyl 4-phenylenediamine; D007501:Iron; D002570:Ceruloplasmin
keywords: Ceruloplasmin; copper; oxidative stress; radical oxygen metabolites