title: Prostate stem cell antigen gene TT genotype and development of intestinal metaplasia in Helicobacter pylori infection.
abstract: OBJECTIVE
  Gastric cancer is etiologically related to interactions between Helicobacter pylori (H. pylori) infection, environmental and host factors. Gastric carcinoma is associated with a cascade of increasing atrophic gastric mucosal damage. Prostate stem cell antigen (PSCA) polymorphisms have been associated with an increased risk of gastric cancer. We aimed to examine the interaction between PSCA polymorphisms and H. pylori in the progression of H. pylori-related gastritis.
  
  
  METHODS
  The genotypes (TT, TC and CC) of PSCA single nucleotide polymorphism rs2294008 among H. pylori infected and uninfected Bhutanese were compared with the severity of H. pylori-related gastritis [neutrophils, monocytes, atrophy scores, H. pylori density, and the presence and extent of intestinal metaplasia (IM)] using the updated Sydney system.
  
  
  RESULTS
  Biopsies from 339 participants were included. The proportion of biopsies with IM was significantly (P < 0.05) greater in those with the TT genotype than in either those with the CT or CC genotype. Although no significant differences were found in inflammation or H. pylori density scores, the scores for IM at both gastric corpus and antrum among participants infected by H. pylori with the TT genotype was significantly (P < 0.05) greater than in the C allele carriers.
  
  
  CONCLUSIONS
  PSCA TT genotype is associated with a more than a threefold increase in the prevalence and the extent of gastric mucosal IM compared to C allele carriers among H. pylori-infected Bhutanese.
authors.affiliation: Department of Gastroenterology and Hepatology, Baylor College of Medicine and Michael DeBakey Veterans Affairs Medical Center, Houston, USA.|Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Oita.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Uotani
authors.affiliation: Division of Digestive Endoscopy, Shiga University of Medical Science Hospital, Otsu.
authors.forename: Mitsushige
authors.initials: M
authors.lastname: Sugimoto
authors.affiliation: First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Ichikawa
authors.affiliation: Department of Gastroenterology and Hepatology, Baylor College of Medicine and Michael DeBakey Veterans Affairs Medical Center, Houston, USA.|Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Oita.
authors.forename: Shingo
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: Gastroenterological Medicine, Rumoi City Hospital, Rumoi.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nagashima
authors.affiliation: Department of Molecular Pathology, Oita University Faculty of Medicine, Yufu, Oita, Japan.
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Uchida
authors.affiliation: Department of Gastroenterology and Hepatology, Baylor College of Medicine and Michael DeBakey Veterans Affairs Medical Center, Houston, USA.
authors.forename: David Y
authors.initials: DY
authors.lastname: Graham
authors.affiliation: Department of Gastroenterology and Hepatology, Baylor College of Medicine and Michael DeBakey Veterans Affairs Medical Center, Houston, USA.|Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Oita.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamaoka
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005773:Gastroscopy; D020022:Genetic Predisposition to Disease; D005838:Genotype; D016481:Helicobacter Infections / Q000150:complications / Q000235:genetics* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D007610:Kallikreins / Q000235:genetics*; D008297:Male; D008679:Metaplasia / Q000235:genetics / Q000382:microbiology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011230:Precancerous Conditions / Q000235:genetics* / Q000382:microbiology* / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000382:microbiology / Q000473:pathology; D055815:Young Adult
chemical_list: C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen
keywords: Helicobacter pylori; gastric neoplasms; intestinal metaplasia; prostate stem cell antigen gene; single nucleotide polymorphism