title: MR Angiography of Renal Transplant Vasculature with Ferumoxytol:: Comparison of High-Resolution Steady-State and First-Pass Acquisitions.
abstract: OBJECTIVE
  This work aimed to quantify the differences in signal-to-noise ratio (SNR) and vessel sharpness between steady-state and first-pass magnetic resonance angiography (MRA) with ferumoxytol in renal transplant recipients.
  
  
  METHODS
  We performed a retrospective study of adult patients who underwent steady-state and first-pass MRA with ferumoxytol to evaluate renal transplant vasculature. SNR was calculated in the external iliac artery, and vessel sharpness was calculated in the external iliac and renal transplant arteries for both acquisitions. Data were compared using Student's t test.
  
  
  RESULTS
  Fifteen patients were included (mean age 56.9 years, 10 males). The mean SNR of the external iliac artery was 42.2 (SD, 11.9) for the first-pass MRA and 41.8 (SD, 9.7) for the steady-state MRA (p = 0.92). The mean vessel sharpness was significantly higher for the steady-state MRA compared to first-pass MRA for both external iliac (1.24 vs. 0.80 mm(-1), p < 0.01) and renal transplant arteries (1.26 vs. 0.79 mm(-1), p < 0.01).
  
  
  CONCLUSIONS
  Steady-state MRA using ferumoxytol improves vessel sharpness while maintaining equivalent SNR compared to conventional first-pass MRA in renal transplant patients.
authors.affiliation: Department of Radiology, University of California, Davis Medical Center, 4860 Y Street, Suite 3100, Sacramento, California 95817, USA. Electronic address: mtcorwin@ucdavis.edu.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Corwin
authors.affiliation: Department of Radiology, University of California, Davis Medical Center, 4860 Y Street, Suite 3100, Sacramento, California 95817, USA.
authors.forename: Ghaneh
authors.initials: G
authors.lastname: Fananapazir
authors.affiliation: Department of Radiology, University of California, Davis Medical Center, 4860 Y Street, Suite 3100, Sacramento, California 95817, USA.
authors.forename: Abhijit J
authors.initials: AJ
authors.lastname: Chaudhari
mesh_terms: D000328:Adult; D000465:Algorithms; D003287:Contrast Media; D005260:Female; D052203:Ferrosoferric Oxide; D006801:Humans; D007083:Iliac Artery / Q000000981:diagnostic imaging; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D007668:Kidney / Q000098:blood supply* / Q000000981:diagnostic imaging; D016030:Kidney Transplantation; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D059629:Signal-To-Noise Ratio
chemical_list: D003287:Contrast Media; D052203:Ferrosoferric Oxide
keywords: MRA; Steady state; contrast; ferumoxytol; nephrotoxicity; renal transplant