title: A model of electrical stimulation of a retinal cell population using a multi-electrode array.
abstract: A novel computational modelling approach is employed to investigate the response of a population of retinal ganglion cells (RGCs) to external electrical stimulation. Current is delivered via a multi-electrode array design that would be employed in a future retinal prosthesis device being developed by our group. The RGCs are morphologically realistic and allow examination of the biophysical responses of intracellular compartments to externally applied currents. A number of stimulation paradigms are simulated including the use of monopolar, hexapolar and quasi-monopolar return paths. The model provides a powerful simulation tool to test and optimize electrical stimulation strategies for future retinal prosthesis devices.
authors.forename: Amr
authors.initials: A
authors.lastname: Al Abed
authors.forename: Nigel H
authors.initials: NH
authors.lastname: Lovell
authors.forename: Gregg
authors.initials: G
authors.lastname: Suaning
authors.forename: Socrates
authors.initials: S
authors.lastname: Dokos
mesh_terms: D004558:Electric Stimulation / Q000295:instrumentation / Q000379:methods; D004566:Electrodes; D006801:Humans; D008959:Models, Neurological; D012165:Retinal Ganglion Cells / Q000502:physiology*