title: Morphology and Function over a One-Year Follow Up Period after Intravitreal Dexamethasone Implant (Ozurdex) in Patients with Diabetic Macular Edema.
abstract: BACKGROUND
  To investigate changes in macular morphology and function after an intravitreal dexamethasone implant for diabetic macular edema (DME).
  
  
  METHODS
  Twenty-seven eyes in 27 treatment-naive patients affected by DME were treated with intravitreal Ozurdex® injections (IVOI) and followed up 12 months to evaluate morphological and functional changes by means of best-corrected visual acuity (BCVA), microperimetry (MP1), multifocal electroretinography (mfERG), pattern electroretinography (PERG) and spectral domain optical coherence tomography (SD-OCT).
  
  
  RESULTS
  Both BCVA and retinal sensitivity improved significantly at one month after the IVOI (p = 0.031 and p<0.0001, respectively). After five months, the improvement of BCVA remained statistically significant compared with baseline values (p = 0.022); retinal sensitivity improvement was statistically significant for up to four months after the IVOI (p = 0.059). Moreover, central macular thickness significantly decreased for up to four months. Interestingly, PERG and mfERG values did not change significantly for up to four months post-IVOI, but then began to worsen.
  
  
  CONCLUSIONS
  In eyes with DME, intravitreal dexamethasone implant determined morphological and functional improvement as soon as one month and for up to four months after the treatment.
authors.affiliation: Ophthalmology Clinic, University of Verona, Verona, Italy.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Mastropasqua
authors.affiliation: Department of Medicine and Science of Aging, Ophthalmology Clinic, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
authors.forename: Lisa
authors.initials: L
authors.lastname: Toto
authors.affiliation: Department of Medicine and Science of Aging, Ophthalmology Clinic, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Borrelli
authors.affiliation: Department of Medicine and Science of Aging, Ophthalmology Clinic, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Di Antonio
authors.affiliation: Department of Medicine and Science of Aging, Ophthalmology Clinic, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: De Nicola
authors.affiliation: Department of Medicine and Science of Aging, Ophthalmology Clinic, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Mastrocola
authors.affiliation: Center of Excellence on Aging and Department of Biomedical Science, University "G. D'Annunzio" of Chieti, Laboratory of Biostatistics, Chieti, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Di Nicola
authors.affiliation: Department of Medicine and Science of Aging, Ophthalmology Clinic, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Carpineto
mesh_terms: D000368:Aged; D003907:Dexamethasone / Q000008:administration & dosage* / Q000627:therapeutic use*; D003930:Diabetic Retinopathy / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D004343:Drug Implants / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D058449:Intravitreal Injections; D008269:Macular Edema / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D013997:Time Factors
chemical_list: D004343:Drug Implants; D003907:Dexamethasone