title: Inflammatory markers and suicidal attempts in depressed patients: A review.
abstract: Major depressive disorder is a chronic and invalidating psychiatric illness and is associated with a greater risk of suicidal behaviors. In recent decades many data have supported a biological link between depressive states and inflammation. Pro-inflammatory cytokines have been found to rise, first of all TNF-α and IL-6. Suicidal behaviors have been consistently associated with increased levels of IL-6 and decreased levels of IL-2. The aim of this review is to investigate the relationship between inflammatory markers in depressed patients with or without suicidal attempts compared to healthy controls.
authors.affiliation: Department of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy sfnmarini@gmail.com.
authors.forename: Stefano
authors.initials: S
authors.lastname: Marini
authors.affiliation: Department of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Vellante
authors.affiliation: Department of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Matarazzo
authors.affiliation: Department of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy.|NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G. Mazzini", ASL 4 Teramo, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: De Berardis
authors.affiliation: NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G. Mazzini", ASL 4 Teramo, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Serroni
authors.affiliation: NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G. Mazzini", ASL 4 Teramo, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Gianfelice
authors.affiliation: NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G. Mazzini", ASL 4 Teramo, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Olivieri
authors.affiliation: NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G. Mazzini", ASL 4 Teramo, Italy.
authors.forename: Fulvia
authors.initials: F
authors.lastname: Di Renzo
authors.affiliation: NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G. Mazzini", ASL 4 Teramo, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Di Marco
authors.affiliation: Department of "Scienze della Formazione", University of Catania, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Fornaro
authors.affiliation: United Hospitals, Academic Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy.|School of Life and Medical Sciences, University of Hertfordshire, Hatfield, Herts, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: Orsolini
authors.affiliation: Villa S. Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Valchera
authors.affiliation: Laboratory of Molecular Psychiatry and Psychopharmacotherapeutics, Section of Psychiatry, Department of Neuroscience, University School of Medicine "Federico II", Naples, Italy.
authors.forename: Felice
authors.initials: F
authors.lastname: Iasevoli
authors.affiliation: Department of Health Science, University of L'Aquila, L'Aquila, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Mazza
authors.affiliation: Hermanas Hospitalarias, Department of Clinical Neurosciences, Villa San Benedetto Menni, Albese con Cassano, Como, Italy.|Department of Psychiatry and Behavioral Sciences, Leonard Miller School of Medicine, University of Miami, Florida, USA.|Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands.
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Perna
authors.affiliation: Department of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinotti
authors.affiliation: Department of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Di Giannantonio
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism; D003865:Major Depressive Disorder / Q000378:metabolism* / Q000523:psychology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000523:psychology*; D013406:Suicide, Attempted / Q000523:psychology*
chemical_list: D015415:Biomarkers; D016207:Cytokines
keywords: inflammatory markers; major depressive disorder; suicidal attempts