title: ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target.
abstract: The ClC-2 chloride channel is a member of the voltage-gated chloride channel family. ClC-2 is involved in various physiological processes, including fluid transport and secretion, regulation of cell volume and pH, maintaining the membrane potential of the cell, cell-to-cell communication, and tissue homeostasis. Recently, our laboratory has accumulated evidence indicating a critical role of ClC-2 in the regulation of intestinal barrier function by altering inter-epithelial tight junction composition. This review will detail the role of ClC-2 in intestinal barrier function during intestinal disorders, including experimental ischemia/reperfusion injury and dextran sodium sulfate (DSS)-induced inflammatory bowel disease. Details of pharmacological manipulation of ClC-2 via prostone agonists will also be provided in an effort to show the potential therapeutic relevance of ClC-2 regulation, particularly during intestinal barrier disruption.
authors.affiliation: Department of Clinical Sciences; College of Veterinary Medicine, North Carolina State University ; Raleigh, NC, USA.
authors.forename: Younggeon
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Department of Clinical Sciences; College of Veterinary Medicine, North Carolina State University ; Raleigh, NC, USA.
authors.forename: Anthony T
authors.initials: AT
authors.lastname: Blikslager
keywords: ClC-2 chloride channel; gastrointestinal diseases; intestinal barrier function; lubiprostone; tight junctions