title: Relationship Between Peritoneal Transport Characteristics and Natriuretic Peptides in Peritoneal Dialysis Patients.
abstract: Few studies have attempted to evaluate the relationship between peritoneal permeability and fluid status in peritoneal dialysis (PD). The aim of the present study was to clarify the relationship between change in the dialysate-to-plasma ratio of creatinine (D/P Cr) and change in fluid status as evaluated by natriuretic peptides. We studied 49 PD patients (29 men, 62 ± 11 years, 36.7% with diabetes) who underwent a peritoneal equilibration test at least twice after PD initiation. We evaluated correlations between the rate of change in the D/P Cr (R C-D/P Cr), the rate of change in a human atrial natriuretic polypeptide (RC-αhANP), and the rate of change in brain natriuretic peptide (RC-BNP). The RC-αhANP was strongly correlated with RC-BNP (r = 0.637, p < 0.001). In contrast, the RC-D/P Cr was not correlated with RC-αhANP (r = 0.041, p = 0.781) or with RC-BNP (r = 0.114, p = 0.435). However, positive correlations between RC-D/P Cr and RC-αhANP (r = 0.530, p = 0.006) and between RC-D/P Cr and RC-BNP (r = 0.625, p = 0.001) were observed in patients with increased D/P Cr The present study showed a positive correlation between change in peritoneal transport characteristics and change influid status in patients whose D/P Cr increased.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kojima
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sakurada
authors.forename: Masahiro
authors.initials: M
authors.lastname: Uehara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Okamoto
authors.forename: Nagayuki
authors.initials: N
authors.lastname: Kaneshiro
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Konno
authors.forename: Yugo
authors.initials: Y
authors.lastname: Shibagaki
mesh_terms: D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001692:Biological Transport; D003404:Creatinine / Q000097:blood*; D015314:Dialysis Solutions / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000378:metabolism*; D010539:Permeability; D051437:Renal Insufficiency / Q000378:metabolism / Q000628:therapy*; D012189:Retrospective Studies
chemical_list: D015314:Dialysis Solutions; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor; D003404:Creatinine