title: A Comparative Study of Lipid-Lowering Effects of Guggul and Atorvastatin Monotherapy in Comparison to Their Combination in High Cholesterol Diet-Induced Hyperlipidemia in Rabbits.
abstract: BACKGROUND
  Hypolipidemic activity of gugulipid has been widely described in traditional literature.
  
  
  OBJECTIVE
  This study was done to evaluate hypolipidemic activity of guggul and atorvaststin monotherapy in comparison to their combination in rabbits.
  
  
  METHODS
  Male New Zealand White rabbits (body weight 1.3-1.8 kg and age 8-10 weeks) were made hyperlipidemic by feeding cholesterol (0.5 g/kg) for three weeks and randomly divided into a control and three treatment groups receiving: atorvastatin (3.7 mg/kg), guggul (3.5 mg/kg) and their combination (same dose) for the next three weeks. Body weight measurements, estimation of serum lipid profile were done at the beginning, after three and six weeks, respectively. Histopathological examination of liver, heart and aorta was done after six weeks. Statistical analysis was done with SPSS version 16.0 using one-way and repeated measures analysis of variance (ANOVA) followed by post-hoc multiple comparison test with two tailed P value < 0.05 as significant.
  
  
  RESULTS
  All treated groups had significant reduction in cholesterol, triglyceride, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) in comparison to pre-treatment values and control group, and had significant increase in high-density lipoprotein (HDL) in comparison to pre-treatment values.
  
  
  CONCLUSIONS
  Combination of atorvastatin and guggul was comparable to their monotherapies in improving lipid profile.
authors.affiliation: a Department of Clinical and Experimental Pharmacology , Calcutta School of Tropical Medicine , Kolkata , India.
authors.forename: Saibal
authors.initials: S
authors.lastname: Das
authors.affiliation: a Department of Clinical and Experimental Pharmacology , Calcutta School of Tropical Medicine , Kolkata , India.
authors.forename: Ankur
authors.initials: A
authors.lastname: Datta
authors.affiliation: a Department of Clinical and Experimental Pharmacology , Calcutta School of Tropical Medicine , Kolkata , India.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Bagchi
authors.affiliation: a Department of Clinical and Experimental Pharmacology , Calcutta School of Tropical Medicine , Kolkata , India.
authors.forename: Sandip
authors.initials: S
authors.lastname: Chakraborty
authors.affiliation: b Hospital Division, National Research Institute of Ayurveda for Drug Development , Kolkata , India.
authors.forename: Achintya
authors.initials: A
authors.lastname: Mitra
authors.affiliation: a Department of Clinical and Experimental Pharmacology , Calcutta School of Tropical Medicine , Kolkata , India.
authors.forename: Santanu Kumar
authors.initials: SK
authors.lastname: Tripathi
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D000069059:Atorvastatin / Q000494:pharmacology*; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000009:adverse effects; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D029744:Commiphora / Q000737:chemistry; D059305:Diet, High-Fat; D004338:Drug Combinations; D006949:Hyperlipidemias / Q000188:drug therapy*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D053149:Plant Gums / Q000494:pharmacology*; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004338:Drug Combinations; D010936:Plant Extracts; D053149:Plant Gums; D014280:Triglycerides; C018562:guggulu extract; D000069059:Atorvastatin
keywords: atorvastatin; cholesterol; guggul; hyperlipidemia; lipid profile; rabbits