title: A framework for parametric modeling of ankle ligaments to determine the in situ response under gross foot motion.
abstract: Ligament sprains account for a majority of injuries to the foot and ankle complex, but ligament properties have not been understood well due to the difficulties in replicating the complex geometry, in situ stress state, and non-uniformity of the strain. For a full investigation of the injury mechanism, it is essential to build up a foot and ankle model validated at the level of bony kinematics and ligament properties. This study developed a framework to parameterize the ligament response for determining the in situ stress state and heterogeneous force-elongation characteristics using a finite element ankle model. Nine major ankle ligaments and the interosseous membrane were modeled as discrete elements corresponding functionally to the ligamentous microstructure of collagen fibers and having parameterized toe region and stiffness at the fiber level. The range of the design variables in the ligament model was determined from existing experimental data. Sensitivity of the bony kinematics to each variable was investigated by design of experiment. The results highlighted the critical role of the length of the toe region of the ligamentous fibers on the bony kinematics with the cumulative influence of more than 95%, while the fiber stiffness was statistically insignificant with an influence of less than 1% under the given variable range and loading conditions. With the flexibility of variable adjustment and high computational efficiency, the presented ankle model was generic in nature so as to maximize its applicability to capture the individual ligament behaviors in future studies.
authors.affiliation: a Center for Applied Biomechanics , University of Virginia , Charlottesville , VA , USA.
authors.forename: Bingbing
authors.initials: B
authors.lastname: Nie
authors.affiliation: a Center for Applied Biomechanics , University of Virginia , Charlottesville , VA , USA.
authors.forename: Matthew Brian
authors.initials: MB
authors.lastname: Panzer
authors.affiliation: a Center for Applied Biomechanics , University of Virginia , Charlottesville , VA , USA.
authors.forename: Adwait
authors.initials: A
authors.lastname: Mane
authors.affiliation: a Center for Applied Biomechanics , University of Virginia , Charlottesville , VA , USA.
authors.forename: Alexander Ritz
authors.initials: AR
authors.lastname: Mait
authors.affiliation: a Center for Applied Biomechanics , University of Virginia , Charlottesville , VA , USA.
authors.forename: John-Paul
authors.initials: JP
authors.lastname: Donlon
authors.affiliation: a Center for Applied Biomechanics , University of Virginia , Charlottesville , VA , USA.
authors.forename: Jason Lee
authors.initials: JL
authors.lastname: Forman
authors.affiliation: a Center for Applied Biomechanics , University of Virginia , Charlottesville , VA , USA.
authors.forename: Richard Wesley
authors.initials: RW
authors.lastname: Kent
mesh_terms: D000465:Algorithms; D000704:Analysis of Variance; D000842:Ankle / Q000502:physiology*; D000843:Ankle Joint / Q000502:physiology; D001696:Biomechanical Phenomena / Q000502:physiology; D006801:Humans; D008023:Ligaments, Articular / Q000502:physiology*; D008954:Models, Biological; D016059:Range of Motion, Articular / Q000502:physiology*
keywords: Parametric modeling; collagen fibers; computational biomechanics; design of experiment; finite element ankle model; sensitivity study