title: Angucycline antibiotics and its derivatives from marine-derived actinomycete Streptomyces sp. A6H.
abstract: Vineomycin A1(1) and B2(2) were isolated from the culture broth of marine actinomycete Streptomyces sp. A6H. Five hydrolysis products were obtained by rational hydrolysis and methanolysis of the fermentation extract. Their structures were characterised as aquayamycin (3), vineomycinone B2(4), 9-C-D-olivosyltetrangulol (5), 7-O-methylgaltamycinone (6) and vineomycinone B2methyl ester (7). In addition to these compounds, two ester derivatives, vineolactone A (8) and vineomycinone B2benzyl ester (9) of compound 4 were generated semisynthetically. Compound 6 is a new analogue of galtamycinone, while compounds 8 and 9 are new members of vineomycins. Cytotoxic activities and antimicrobial activities were determined for all compounds. The results indicate that only compound 1 showed significant activities with IC50value of 0.34 μM against H1975 and MIC value of 4 μg/mL against Staphylococcus aureus.
authors.affiliation: a Ocean College , Zhejiang University , Hangzhou , P.R. China.
authors.forename: Zhijuan
authors.initials: Z
authors.lastname: Hu
authors.affiliation: a Ocean College , Zhejiang University , Hangzhou , P.R. China.
authors.forename: Lele
authors.initials: L
authors.lastname: Qin
authors.affiliation: a Ocean College , Zhejiang University , Hangzhou , P.R. China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: a Ocean College , Zhejiang University , Hangzhou , P.R. China.
authors.forename: Wanjing
authors.initials: W
authors.lastname: Ding
authors.affiliation: b Zhejiang Key Laboratory of Gastro-Intestinal Pathophysiology , Zhejiang Hospital of Traditional Chinese Medicine , Hangzhou , P.R. China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Chen
authors.affiliation: a Ocean College , Zhejiang University , Hangzhou , P.R. China.
authors.forename: Zhongjun
authors.initials: Z
authors.lastname: Ma
keywords: Streptomyces sp. A6H; angucycline; hydrolysis; semisynthesis