title: Impact on behavioral changes due to chronic use of sertraline in Wistar albino rats.
abstract: OBJECTIVE
  Despite having better tolerability and a wide range of clinical applications over other antidepressants, selective serotonin reuptake inhibitors (SSRIs) are also known to be associated with serious adverse effects like suicidal ideation on chronic use. The present study had explored the impact of the chronic use of sertraline, an SSRI, on the behavioral changes in Wistar albino rats.
  
  
  METHODS
  The study was conducted on 30 Wistar albino rats of either sex; divided into five groups. Four groups were subjected to chronic mild stress induced by using various stressors randomly scheduled in a week and continued for a period of 3 weeks. The stressed rodents were subjected to sertraline treatment for 9 weeks in different human therapeutic doses extrapolated to animal doses. Behavioral changes were monitored, assessed, and evaluated throughout the treatment phase with the help of tests such as locomotor activity test, forced swim test, tail suspension test, antianxiety test, and sucrose preference test (SPT).
  
  
  RESULTS
  All tests except SPT, demonstrated significant (P < 0.05) reduction in depressive-like activity in the stressed rodents by the mid-treatment phase, followed by an abrupt onset of the depressive state by the end of the treatment phase. SPT showed a significant (P < 0.05) increase in sucrose consumption throughout the treatment phase.
  
  
  CONCLUSIONS
  Behavioral changes following chronic sertraline administration conferred gradual remission of depression state on initial treatment phase, followed by a reversal of effect on chronic use.
authors.affiliation: Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India; Department of Pharmacology, NSHM Knowledge Campus, Kolkata-Group of Institutions, Kolkata, West Bengal, India.
authors.forename: Shatavisa
authors.initials: S
authors.lastname: Mukherjee
authors.affiliation: Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
authors.forename: Sukanta
authors.initials: S
authors.lastname: Sen
authors.affiliation: Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
authors.forename: Arunava
authors.initials: A
authors.lastname: Biswas
authors.affiliation: Department of Pharmacology, NSHM Knowledge Campus, Kolkata-Group of Institutions, Kolkata, West Bengal, India.
authors.forename: Tapan Kumar
authors.initials: TK
authors.lastname: Barman
authors.affiliation: Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
authors.forename: Santanu Kumar
authors.initials: SK
authors.lastname: Tripathi
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D003863:Depression / Q000188:drug therapy* / Q000209:etiology; D004195:Disease Models, Animal; D004361:Drug Tolerance; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D005518:Food Preferences / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D020280:Sertraline / Q000008:administration & dosage* / Q000627:therapeutic use; D013312:Stress, Physiological; D013315:Stress, Psychological / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline
keywords: Behavioral changes; chronic mild stress; selective serotonin reuptake inhibitors; sertraline