title: Transcriptional Control of Dendritic Cell Development.
abstract: The dendritic cells (DCs) of the immune system function in innate and adaptive responses by directing activity of various effector cells rather than serving as effectors themselves. DCs and closely related myeloid lineages share expression of many surface receptors, presenting a challenge in distinguishing their unique in vivo functions. Recent work has taken advantage of unique transcriptional programs to identify and manipulate murine DCs in vivo. This work has assigned several nonredundant in vivo functions to distinct DC lineages, consisting of plasmacytoid DCs and several subsets of classical DCs that promote different immune effector modules in response to pathogens. In parallel, a correspondence between human and murine DC subsets has emerged, underlying structural similarities for the DC lineages between these species. Recent work has begun to unravel the transcriptional circuitry that controls the development and diversification of DCs from common progenitors in the bone marrow.
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
authors.forename: Theresa L
authors.initials: TL
authors.lastname: Murphy
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
authors.forename: Gary E
authors.initials: GE
authors.lastname: Grajales-Reyes
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
authors.forename: Xiaodi
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Biomedicine, University of Basel, 4058 Basel, Switzerland.
authors.forename: Roxane
authors.initials: R
authors.lastname: Tussiwand
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
authors.forename: Carlos G
authors.initials: CG
authors.lastname: Briseño
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
authors.forename: Arifumi
authors.initials: A
authors.lastname: Iwata
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Kretzer
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
authors.forename: Vivek
authors.initials: V
authors.lastname: Durai
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.|Howard Hughes Medical Institute, Washington University School of Medicine in St. Louis, Missouri 63110.
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Murphy
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology*; D002454:Cell Differentiation; D019070:Cell Lineage; D003713:Dendritic Cells / Q000502:physiology*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics; D051379:Mice; D015533:Transcriptional Activation
keywords: common dendritic progenitor; dendritic cell; lineage commitment; transcription factors