title: [Research Progress on Chemoresistance Mechanism of Nuclear Factor Kappa B Signalling Patheway in Acute Myeloid Leukemia].
abstract: Acute myeloid leukemia (AML) is the most common leukemia in adult, among them the childhood acute myeloid leukemia accounts for 15% to 20%. After exploring and investigating this disease for 60 years, the systematic chemotherapy can achieve complete remission for 75%-80% AML patients, but only 20%-30% AML patients out of them can be cured, and other AML patients relapsed or died of this disease. The primary and/or seondary chemotherapy resistance may be the main reasons of the poor prognosis in AML. The activity of nuclear factor kappa B (NF-κB) involved into multi-layers of physiological functions. Among them, the activity of NF-κB and the apoptosis toleration associated with the sensitivity to chemotherapy. All these indicated that the inhibition of NF-κB may be a promising direction to reverse chemoresistance and improve chemotherapeutic effects for AML. Herein is the review of recent research progress on the field of the roles of NF-κB activation in AML and its application in AML therapy.
authors.affiliation: Department of Pediatrics, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong Province, China.
authors.forename: Ran-Ran
authors.initials: RR
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong Province, China. E-mail: zhanghuirjh@sjtu.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong Province, China. E-mail: chen_fuxiong@163.com.
authors.forename: Fu-Xiong
authors.initials: FX
authors.lastname: Chen
mesh_terms: D017209:Apoptosis; D019008:Drug Resistance, Neoplasm; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D016328:NF-kappa B; D012074:Remission Induction; D015398:Signal Transduction
chemical_list: D016328:NF-kappa B