title: Vaccine-Induced Antibody Responses Prevent the Induction of Interferon Type I Responses Upon a Homotypic Live Virus Challenge.
abstract: During acute viral infections, innate immunity provides essential protective measures to minimize virus dissemination and regulate adaptive immunity. This helps to successfully eliminate the pathogen and establish long-term memory. Here, we investigated the effect of vaccine-induced antibody responses on the induction of IFN-I responses and the associated lymphocyte activation using influenza A virus vaccination and challenge models. Mice were vaccinated with gamma-irradiated influenza A virus (γ-FLU) and challenged three weeks later with live virus. Our data show a significant reduction in IFN-I responses and lymphocyte activation following a homotypic virus challenge. We confirmed the role of vaccine-induced antibody responses in the observed impairment of IFN-I and the associated lymphocyte activation using adoptive transfer of immune sera and the administration of sera-treated viruses prior to challenge. Overall, we addressed a fundamental concept in immunology and provided experimental data illustrating the inhibition of IFN-I responses in vaccinated animals upon a homotypic virus challenge.
authors.affiliation: Vaccine Research Group, Centre for Molecular Pathology, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Chan
authors.affiliation: Vaccine Research Group, Centre for Molecular Pathology, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Babb
authors.affiliation: Vaccine Research Group, Centre for Molecular Pathology, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia.
authors.forename: S C
authors.initials: SC
authors.lastname: David
authors.affiliation: Vaccine Research Group, Centre for Molecular Pathology, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia.
authors.forename: S R
authors.initials: SR
authors.lastname: McColl
authors.affiliation: Vaccine Research Group, Centre for Molecular Pathology, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Alsharifi
mesh_terms: D000818:Animals; D000917:Antibody Formation; D002460:Cell Line; D006224:Cricetinae; D004285:Dogs; D005260:Female; D005720:Gamma Rays; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000276:immunology* / Q000517:prevention & control; D007370:Interferon Type I / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000517:prevention & control; D014611:Vaccination; D014613:Vaccines, Attenuated
chemical_list: D007252:Influenza Vaccines; D007370:Interferon Type I; D014613:Vaccines, Attenuated