title: Diagnosis and management of aortic valve stenosis in patients with heart failure.
abstract: Aortic stenosis (AS) is the most frequent degenerative valvular heart disease in Western countries and its prevalence increases in parallel with the ageing process of the population. Heart failure (HF), defined by the presence of reduced left ventricular ejection fraction, may be present in up to a quarter of patients with severe AS, posing diagnostic and management challenges. The present article reviews the prevalence of HF in severe AS patients, discusses the diagnostic challenges and the advances in multimodality imaging to identify the patients that may benefit from surgical or transcatheter aortic valve replacement, and summarizes the current evidence on management for this group of patients.
authors.affiliation: Department of Cardiology, Heart and Lung Centrum, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.|Department of Cardiology, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Vasileios
authors.initials: V
authors.lastname: Kamperidis
authors.affiliation: Department of Cardiology, Heart and Lung Centrum, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.
authors.forename: Victoria
authors.initials: V
authors.lastname: Delgado
authors.affiliation: Department of Cardiology, Thoraxcenter, Erasmus Medical Centre, Rotterdam, the Netherlands.
authors.forename: Nicolas M
authors.initials: NM
authors.lastname: van Mieghem
authors.affiliation: Department of Cardio-Thoracic Surgery, Erasmus Medical Centre, Rotterdam, the Netherlands.
authors.forename: Arie-Pieter
authors.initials: AP
authors.lastname: Kappetein
authors.affiliation: Columbia University Medical Center and The Cardiovascular Research Foundation, New York, NY, USA.
authors.forename: Martin B
authors.initials: MB
authors.lastname: Leon
authors.affiliation: Department of Cardiology, Heart and Lung Centrum, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.
authors.forename: Jeroen J
authors.initials: JJ
authors.lastname: Bax
mesh_terms: D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000601:surgery; D015897:Comorbidity; D019468:Disease Management; D004452:Echocardiography; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D006976:Hypertension, Pulmonary / Q000453:epidemiology; D008279:Magnetic Resonance Imaging; D008944:Mitral Valve Insufficiency / Q000453:epidemiology; D017202:Myocardial Ischemia / Q000453:epidemiology; D015995:Prevalence; D018570:Risk Assessment; D012720:Severity of Illness Index; D013318:Stroke Volume; D065467:Transcatheter Aortic Valve Replacement
keywords: Aortic stenosis; Heart failure; Multi-detector computed tomography; Stress echocardiography; Transcatheter aortic valve replacement