title: Integrated Circuit-Based Biofabrication with Common Biomaterials for Probing Cellular Biomechanics.
abstract: Recent advances in bioengineering have enabled the development of biomedical tools with modifiable surface features (small-scale architecture) to mimic extracellular matrices and aid in the development of well-controlled platforms that allow for the application of mechanical stimulation for studying cellular biomechanics. An overview of recent developments in common biomaterials that can be manufactured using integrated circuit-based biofabrication is presented. Integrated circuit-based biofabrication possesses advantages including mass and diverse production capacities for fabricating in vitro biomedical devices. This review highlights the use of common biomaterials that have been most frequently used to study cellular biomechanics. In addition, the influence of various small-scale characteristics on common biomaterial surfaces for a range of different cell types is discussed.
authors.affiliation: Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Chun-Yen
authors.initials: CY
authors.lastname: Sung
authors.affiliation: Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Chung-Yao
authors.initials: CY
authors.lastname: Yang
authors.affiliation: Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: J Andrew
authors.initials: JA
authors.lastname: Yeh
authors.affiliation: Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan. Electronic address: chaomin@mx.nthu.edu.tw.
authors.forename: Chao-Min
authors.initials: CM
authors.lastname: Cheng
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D057005:Bioengineering / Q000379:methods*; D001696:Biomechanical Phenomena; D002468:Cell Physiological Phenomena; D006801:Humans; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials
keywords: cellular biomechanics; integrated circuit-based biofabrication; small-scale architecture