title: Male Gender and Body Mass Index Are Associated With Hypertension and Reduced Kidney Function 5 or More Years After Living Kidney Donation.
abstract: BACKGROUND
  The objective of this study was to evaluate renal function and to explore the relationship between some risk factors in kidney donors 12.37 ± 7.60 years after donation.
  
  
  METHODS
  In a cross-sectional study conducted in a transplant unit, 77 nephrectomized subjects were assessed ≥5 years after donation to evaluate their renal function and the presence or absence of hypertension, dyslipidemia, and microalbuminuria.
  
  
  RESULTS
  Twenty donors had an estimated glomerular filtration rate of <60 mL/min/1.73 m(2). Nine donors showed urinary albumin excretion of >20 μg/min (11.68%). Subjects with an EGFR of <60 mL/min were predominantly male and hypertensive and showed higher body mass index (BMI), higher uric acid, higher total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C), and logarithm of triglycerides/HDL-C (log TG/HDL-C) ratios than donors with an EGFR of >60 mL/min. Hypertensive donors were older and had higher BMI, higher UA serum values, higher TC/HDL-C and log TG/HDL-C ratios and microalbuminuria than nonhypertensive donors (P < .005). A multivariate analysis was conducted and, after final adjustment, a filtration rate of <60 mL/min was 3.05 times higher in men than women, increased 10% for each 1-unit increase in BMI and was positively associated with log (TG/HDL-C). The frequency of hypertension increased by 10% for each 1-unit increase in BMI and was positively associated with microalbuminuria.
  
  
  CONCLUSIONS
  In this sample of kidney donors from a single transplant unit, ≥5 years after donation, male sex and high BMI were positively associated with the presence of kidney failure.
authors.affiliation: Department of Nephrology and Transplant of the Federal District Hospital, Brasilia, Brazil. Electronic address: robertacasanovas@terra.com.
authors.forename: R C
authors.initials: RC
authors.lastname: Bello
authors.affiliation: Department of Nephrology and Transplant of the Federal District Hospital, Brasilia, Brazil.
authors.forename: V A
authors.initials: VA
authors.lastname: Bello
authors.affiliation: Division of Nephrology, Catholic University, Faculty of Medicine, Brasilia, Brazil.
authors.forename: T T
authors.initials: TT
authors.lastname: Rosa
authors.affiliation: Division of Cardiology, University of Brasilia Hospital, Faculty of Medicine, Brasilia, Brazil.
authors.forename: L F
authors.initials: LF
authors.lastname: Junqueira
authors.affiliation: Department of Statistics, University of Brasilia Hospital, Faculty of Medicine, Brasilia, Brazil.
authors.forename: E
authors.initials: E
authors.lastname: Freitas
authors.affiliation: Division of Nephrology, University of Brasilia Hospital, Faculty of Medicine, Brasilia, Brazil.
authors.forename: J P R
authors.initials: JP
authors.lastname: Veiga
mesh_terms: D000419:Albuminuria / Q000150:complications; D015992:Body Mass Index; D001938:Brazil; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000150:complications*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency / Q000150:complications*; D012307:Risk Factors; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides