title: Squamous Cell Carcinoma Following Photodynamic Therapy for Cutaneous Bowen's Disease in a Series of 105 Patients.
abstract: Photodynamic therapy (PDT) is an alternative to surgery for Bowen's disease. This monocentric retrospective study included 105 patients with Bowen's disease, treated with PDT between 2007 and 2013, who received a total of 151 different PDT fields. Comparison of immunocompromised and non-immunocompromised patients revealed that the former often had a previous history of squamous cell carcinoma (SCC; p = 0.004) and received more PDT fields (p = 0.007) than the latter. At least one SCC occurred post-PDT in 16 out of 105 patients in a PDT field. However, many of the patients were at risk of SCC and the possibility that the lesion did not have a mixed histology at baseline, but might simply be a transformation of non-PDT-responsive Bowen's disease, cannot be excluded. Although it is rare, patients should be closely monitored for SCC post-PDT.
authors.affiliation: Department of Dermatology, Saint Louis Hospital, Paris 7 University, 75010 Paris, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Ratour-Bigot
authors.forename: Mireille
authors.initials: M
authors.lastname: Chemidling
authors.forename: Claire
authors.initials: C
authors.lastname: Montlahuc
authors.forename: Georges
authors.initials: G
authors.lastname: Abirached
authors.forename: Nika
authors.initials: N
authors.lastname: Madjlessi
authors.forename: Chantal
authors.initials: C
authors.lastname: Bullier
authors.forename: Maxime
authors.initials: M
authors.lastname: Battistella
authors.forename: Martine
authors.initials: M
authors.lastname: Bagot
authors.forename: Céleste
authors.initials: C
authors.lastname: Lebbe
authors.forename: Nicole
authors.initials: N
authors.lastname: Basset-Seguin
mesh_terms: D000368:Aged; D001913:Bowen's Disease / Q000188:drug therapy*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D010778:Photochemotherapy / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000188:drug therapy*; D016896:Treatment Outcome