title: FOXC2 is up-regulated in pancreatic ductal adenocarcinoma and promotes the growth and migration of cancer cells.
abstract: The transcriptional factor Forkhead box protein C2 (FOXC2) was recently demonstrated to be up-regulated in various cancer types. However, its expression profile and the biological functions in pancreatic cancer remain unknown. In this study, we examined the expression pattern of FOXC2 in pancreatic ductal adenocarcinoma (PDAC) tissues and investigated the functions of FOXC2 in the progression of PDAC. It was found that the expression of FOXC2 was up-regulated in PDAC samples. Forced expression of FOXC2 promoted the growth and migration of the PDAC cells, while knocking down the expression of FOXC2 inhibited the growth and migration of the PDAC cells. Moreover, FOXC2 was found to interact with beta-catenin and promote cell growth by activating beta-catenin/TCF signaling. Taken together, this study demonstrated the oncogenic roles of FOXC2 in PDAC, and FOXC2 might be a therapeutic target for PDAC.
authors.affiliation: General Surgery Department, Affiliated Hospital, Jiangsu University, 438 Jie-Fang Rd., Zhenjiang, 212003, Jiangsu Province, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Cui
authors.affiliation: General Surgery Department, Affiliated Hospital, Jiangsu University, 438 Jie-Fang Rd., Zhenjiang, 212003, Jiangsu Province, People's Republic of China.
authors.forename: Shengchun
authors.initials: S
authors.lastname: Dang
authors.affiliation: General Surgery Department, Affiliated Hospital, Jiangsu University, 438 Jie-Fang Rd., Zhenjiang, 212003, Jiangsu Province, People's Republic of China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Qu
authors.affiliation: General Surgery Department, Affiliated Hospital, Jiangsu University, 438 Jie-Fang Rd., Zhenjiang, 212003, Jiangsu Province, People's Republic of China.
authors.forename: Zhengfa
authors.initials: Z
authors.lastname: Mao
authors.affiliation: General Surgery Department, Affiliated Hospital, Jiangsu University, 438 Jie-Fang Rd., Zhenjiang, 212003, Jiangsu Province, People's Republic of China.
authors.forename: Xuqing
authors.initials: X
authors.lastname: Wang
authors.affiliation: General Surgery Department, Affiliated Hospital, Jiangsu University, 438 Jie-Fang Rd., Zhenjiang, 212003, Jiangsu Province, People's Republic of China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: General Surgery Department, Affiliated Hospital, Jiangsu University, 438 Jie-Fang Rd., Zhenjiang, 212003, Jiangsu Province, People's Republic of China. chengjixiang1010@sina.com.
authors.forename: Jixiang
authors.initials: J
authors.lastname: Chen
mesh_terms: D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D015153:Blotting, Western; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D016022:Case-Control Studies; D002465:Cell Movement; D049109:Cell Proliferation; D005500:Follow-Up Studies; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D047468:Immunoprecipitation; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015996:Survival Rate; D014407:Tumor Cells, Cultured
chemical_list: D014408:Biomarkers, Tumor; D051858:Forkhead Transcription Factors; D012333:RNA, Messenger; C082078:mesenchyme fork head 1 protein
keywords: Beta-catenin/TCF signaling; Cell growth and migration; FOXC2; PDAC