title: Highly water-dispersible silver sulfadiazine decorated with polyvinyl pyrrolidone and its antibacterial activities.
abstract: Highly water-dispersible silver sulfadiazine (SSD) was prepared by liquid phase method with polyvinyl pyrrolidone (PVP) as a surface modification agent. The structure and morphology of the PVP-modified silver sulfadiazine (P-SSD) were investigated by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and Fourier-transform infrared (FT-IR) spectrometry. The produced particles are ginkgo leaf-like architecture with the sizes of micron-nanometer. Due to hydrophilic PVP decorated on the surface, the P-SSD has excellent dispersion in water over a period of 24h, which is obviously stable by comparison to that of the commercial silver sulfadiazine (C-SSD). In addition, the P-SSD exhibits good antibacterial activities against Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus).
authors.affiliation: Key Laboratory for Special Functional Materials, Henan University, Kaifeng 475004, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: Key Laboratory for Special Functional Materials, Henan University, Kaifeng 475004, PR China.
authors.forename: Longlong
authors.initials: L
authors.lastname: Wu
authors.affiliation: Key Laboratory for Special Functional Materials, Henan University, Kaifeng 475004, PR China; Medical School of Henan University, Kaifeng 475004, PR China. Electronic address: lbj821@163.com.
authors.forename: Binjie
authors.initials: B
authors.lastname: Li
authors.affiliation: Key Laboratory for Special Functional Materials, Henan University, Kaifeng 475004, PR China.
authors.forename: Yanbao
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Chemistry, Shangqiu Normal University, Shangqiu 476000, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Qu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011205:Povidone / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012837:Silver Sulfadiazine / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D011205:Povidone; D012837:Silver Sulfadiazine
keywords: Antibacterial activities; Polyvinyl pyrrolidone; Silver sulfadiazine; Water-dispersible