title: Proton magnetic resonance spectroscopy in oncology: the fingerprints of cancer?
abstract: Abnormal metabolism is a key tumor hallmark. Proton magnetic resonance spectroscopy (1H-MRS) allows measurement of metabolite concentration that can be utilized to characterize tumor metabolic changes. 1H-MRS measurements of specific metabolites have been implemented in the clinic. This article performs a systematic review of image acquisition and interpretation of 1H-MRS for cancer evaluation, evaluates its strengths and limitations, and correlates metabolite peaks at 1H-MRS with diagnostic and prognostic parameters of cancer in different tumor types.
authors.affiliation: Department of Radiology, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain. roberto.garcia.figueiras@sergas.es.
authors.forename: Roberto
authors.initials: R
authors.lastname: García-Figueiras
authors.forename: Sandra
authors.initials: S
authors.lastname: Baleato-González
authors.forename: Anwar R
authors.initials: AR
authors.lastname: Padhani
authors.forename: Laura
authors.initials: L
authors.lastname: Oleaga
authors.forename: Joan C
authors.initials: JC
authors.lastname: Vilanova
authors.forename: Antonio
authors.initials: A
authors.lastname: Luna
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Cobas Gómez
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D011379:Prognosis; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods*; D012680:Sensitivity and Specificity