title: The Role of Matrix Metalloproteinase-9 (MMP-9) as a Prognostic Factor in Epithelial and Lymphatic Neoplasia.
abstract: Matrix metalloproteinase 9 is a zinc-dependent extracellular matrix remodeling endopeptidase directly involved in the local invasion mechanisms and in metastasis. The current review aims to evaluate the expression of MMP-9 and its prognostic value in the most common epithelial and lymphatic neoplasia of the pelvic-abdominal region. We included 19 studies published between January 1st, 1995 and July 31st 2015, involving a total of 1523 patients. The analysis indicate that MMP-9 is valid marker of poor survival in epithelial and lymphatic neoplasia.
authors.forename: V
authors.initials: V
authors.lastname: Pârvănescu
authors.forename: M
authors.initials: M
authors.lastname: Georgescu
authors.forename: I
authors.initials: I
authors.lastname: Georgescu
authors.forename: V
authors.initials: V
authors.lastname: Șurlin
authors.forename: Ș
authors.initials: Ș
authors.lastname: Pătraşcu
authors.forename: A M
authors.initials: AM
authors.lastname: Picleanu
authors.forename: E
authors.initials: E
authors.lastname: Georgescu
mesh_terms: D000008:Abdominal Neoplasms / Q000097:blood / Q000175:diagnosis*; D014408:Biomarkers, Tumor / Q000097:blood*; D002277:Carcinoma / Q000097:blood / Q000175:diagnosis*; D019317:Evidence-Based Medicine; D006801:Humans; D008223:Lymphoma / Q000097:blood / Q000175:diagnosis*; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D010386:Pelvic Neoplasms / Q000097:blood / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D020780:Matrix Metalloproteinase 9