title: Determination of Insecticidal Effect (LC50 and LC90) of Organic Fatty Acids Mixture (C8910+Silicone) Against Aedes aegypti and Aedes albopictus (Diptera: Culicidae).
abstract: Emerging and re-emerging vector-borne diseases such as chikungunya and dengue and associated Aedes vectors are expanding their historical ranges; thus, there is a need for the development of novel insecticides for use in vector control programs. The mosquito toxicity of a novel insecticide and repellent consisting of medium-chain carbon fatty acids (C8910) was examined. Determination of LC50and LC90was made against colony-reared Aedes aegypti (L.) and Aedes albopictus (Skuse) using probit analysis on mortality data generated by Centers for Disease Control and Prevention bottle bioassays. Six different concentrations of C8910 + silicone oil yielded an LC50of 160.3 µg a.i/bottle (147.6-182.7) and LC90of 282.8 (233.2-394.2) in Ae. aegypti; five concentrations yielded an LC50of 125.4 (116.1-137.6) and LC90of 192.5 (165.0-278.9) in Ae. albopictus. Further development of C8910 and similar compounds could provide vector control specialists novel insecticides for controlling insect disease vectors.
authors.affiliation: Navy Environmental and Preventive Medicine Unit 2, Norfolk, VA 23511 (dunford@ufl.edu), dunford@ufl.edu.
authors.forename: James C
authors.initials: JC
authors.lastname: Dunford
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA 30341 (aneikafalconer@gmail.com; xhn4@cdc.gov; bew5@cdc.gov; wgb1@cdc.gov).
authors.forename: Aneika
authors.initials: A
authors.lastname: Falconer
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA 30341 (aneikafalconer@gmail.com; xhn4@cdc.gov; bew5@cdc.gov; wgb1@cdc.gov).
authors.forename: Laura N
authors.initials: LN
authors.lastname: Leite
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA 30341 (aneikafalconer@gmail.com; xhn4@cdc.gov; bew5@cdc.gov; wgb1@cdc.gov).
authors.forename: Robert A
authors.initials: RA
authors.lastname: Wirtz
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA 30341 (aneikafalconer@gmail.com; xhn4@cdc.gov; bew5@cdc.gov; wgb1@cdc.gov).
authors.forename: William G
authors.initials: WG
authors.lastname: Brogdon
mesh_terms: D000330:Aedes / Q000187:drug effects* / Q000254:growth & development; D000818:Animals; D005227:Fatty Acids / Q000633:toxicity*; D007303:Insect Vectors / Q000187:drug effects* / Q000254:growth & development; D007306:Insecticides / Q000633:toxicity*; D012828:Silicones / Q000633:toxicity*
chemical_list: D005227:Fatty Acids; D007306:Insecticides; D012828:Silicones
keywords: Aedes; C8910; LC50; LC90; bioassay