title: A 3D paper-based enzymatic fuel cell for self-powered, low-cost glucose monitoring.
abstract: In this work, we demonstrate a novel low-cost, self-powered paper-based biosensor for glucose monitoring. The device operating mechanism is based on a glucose/oxygen enzymatic fuel cell using an electrochemical energy conversion as a transducing element for glucose monitoring. The self-powered glucose biosensor features (i) a 3D origami paper-based structure for easy system integration onto paper, (ii) an air-cathode on paper for low-cost production and easy operation, and (iii) a screen printed chitosan/glucose oxidase anode for stable current generation as an analytical signal for glucose monitoring. The sensor showed a linear range of output current at 1-5mM glucose (R(2)=0.996) with a sensitivity of 0.02 µA mM(-1). The advantages offered by such a device, including a low cost, lack of external power sources/sophisticated external transducers, and the capacity to rapidly generate reliable results, are well suited for the clinical and social settings of the developing world.
authors.affiliation: Briarcliff High School, 444 Pleasantville Rd., Briarcliff Manor, NY, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Fischer
authors.affiliation: Bioelectronics & Microsystems Laboratory, Department of Electrical & Computer Engineering, State University of New York at Binghamton, 4400 Vestal Pkwy, Binghamton, NY 13902, USA.
authors.forename: Arwa
authors.initials: A
authors.lastname: Fraiwan
authors.affiliation: Bioelectronics & Microsystems Laboratory, Department of Electrical & Computer Engineering, State University of New York at Binghamton, 4400 Vestal Pkwy, Binghamton, NY 13902, USA. Electronic address: sechoi@binghamton.edu.
authors.forename: Seokheun
authors.initials: S
authors.lastname: Choi
mesh_terms: D001674:Bioelectric Energy Sources; D015374:Biosensing Techniques; D004566:Electrodes; D005947:Glucose / Q000302:isolation & purification*; D005949:Glucose Oxidase / Q000737:chemistry*; D010100:Oxygen; D010209:Paper
chemical_list: D005949:Glucose Oxidase; D005947:Glucose; D010100:Oxygen
keywords: Biosensors; Enzymatic fuel cells; Glucose monitoring; Paper-based devices; Self-powered sensors