title: Both heat and new chemotherapeutic drug dioxadet in hyperthermic intraperitoneal chemoperfusion improved survival in rat ovarian cancer model.
abstract: OBJECTIVE
  Hyperthermic Intraperitoneal Chemotherapy (HIPEC) at the time of Cytoreductive Surgery (CRS) is an actively researched treatment in patients with advanced ovarian cancer. Relative contribution of heat and chemotherapeutic agents during HIPEC as well as efficacy of a new agent dioxadet for regional chemotherapy in a rat model of ovarian cancer was studied.
  
  
  METHODS
  Sixty rats were divided into three groups: no treatment control group (n = 19), hyperthermia without chemotherapy (HIPEP) (n = 14), HIPEC + cisplatin (n = 14), HIPEC + dioxadet (n = 13). The intra-abdominal tumor was not resected. End points were: median survival (primary), cause of death (secondary).
  
  
  RESULTS
  The median survival of the animals in the control group, HIPEP group, HIPEC + cisplatin, HIPEC + dioxadet were 9 (CI; 8-23), 22.5 (CI; 12-43), 25.5 (CI; 13-62), 49 (Cl; 28-70) days, respectively. The P-values control versus HIPEP, HIPEC + cisplatin versus HIPEC + dioxadet were 0.006, 0.002, and 0.001, respectively.
  
  
  CONCLUSIONS
  During HIPEC both the heat and the cytotoxic drug had antitumor effects in a rat ovarian cancer model. Dioxadet showed potential as a drug for regional chemotherapy. J. Surg. Oncol. 2016;113:438-442. © 2015 Wiley Periodicals, Inc.
authors.affiliation: Department of Cancer Chemoprevention and Oncopharmacology in N.N. Petrov Research Institute of Oncology of the Russian Ministry of Health, 68, Leningradskaya Street, Pesochny, Saint-Petersburg, Russia.|ITMO University, 49, Kronverksky Avenue, Saint-Petersburg, Russia.
authors.forename: Vladimir G
authors.initials: VG
authors.lastname: Bespalov
authors.affiliation: Department of Cancer Chemoprevention and Oncopharmacology in N.N. Petrov Research Institute of Oncology of the Russian Ministry of Health, 68, Leningradskaya Street, Pesochny, Saint-Petersburg, Russia.|ITMO University, 49, Kronverksky Avenue, Saint-Petersburg, Russia.
authors.forename: Galina S
authors.initials: GS
authors.lastname: Kireeva
authors.affiliation: Department of Cancer Chemoprevention and Oncopharmacology in N.N. Petrov Research Institute of Oncology of the Russian Ministry of Health, 68, Leningradskaya Street, Pesochny, Saint-Petersburg, Russia.|ITMO University, 49, Kronverksky Avenue, Saint-Petersburg, Russia.
authors.forename: Olesya A
authors.initials: OA
authors.lastname: Belyaeva
authors.affiliation: Lugansk Oncological Dispensary, Lugansk, Ukraine, 8, Krasnodonskaya Street, Lugansk, Ukraine.
authors.forename: Oleksiy E
authors.initials: OE
authors.lastname: Kalinin
authors.affiliation: Department of Cancer Chemoprevention and Oncopharmacology in N.N. Petrov Research Institute of Oncology of the Russian Ministry of Health, 68, Leningradskaya Street, Pesochny, Saint-Petersburg, Russia.
authors.forename: Konstantin Y
authors.initials: KY
authors.lastname: Senchik
authors.affiliation: Department of Cancer Chemoprevention and Oncopharmacology in N.N. Petrov Research Institute of Oncology of the Russian Ministry of Health, 68, Leningradskaya Street, Pesochny, Saint-Petersburg, Russia.
authors.forename: Alexandr N
authors.initials: AN
authors.lastname: Stukov
authors.affiliation: Department of Cancer Chemoprevention and Oncopharmacology in N.N. Petrov Research Institute of Oncology of the Russian Ministry of Health, 68, Leningradskaya Street, Pesochny, Saint-Petersburg, Russia.
authors.forename: Georgy I
authors.initials: GI
authors.lastname: Gafton
authors.affiliation: Department of Cancer Chemoprevention and Oncopharmacology in N.N. Petrov Research Institute of Oncology of the Russian Ministry of Health, 68, Leningradskaya Street, Pesochny, Saint-Petersburg, Russia.
authors.forename: Konstantin D
authors.initials: KD
authors.lastname: Guseynov
authors.affiliation: Department of Cancer Chemoprevention and Oncopharmacology in N.N. Petrov Research Institute of Oncology of the Russian Ministry of Health, 68, Leningradskaya Street, Pesochny, Saint-Petersburg, Russia.
authors.forename: Alexey M
authors.initials: AM
authors.lastname: Belyaev
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D005260:Female; D006979:Hyperthermia, Induced / Q000379:methods*; D007263:Infusions, Parenteral; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000628:therapy*; D011897:Random Allocation; D051381:Rats; D014227:Triazines / Q000008:administration & dosage*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D014227:Triazines; C040269:dioxadet; D002945:Cisplatin
keywords: cisplatin; dioxadet; hyperthermic intraperitoneal chemoperfusion (HIPEC); ovarian cancer; peritoneal carcinomatosis