title: Correlation between nutritional, hematological and infectious characteristics and classification of the type of epidermolysis bullosa of patients assisted at the Dermatology Clinic of the Hospital Universitário de Brasília.
abstract: Epidermolysis bullosa comprises a group of phenotypically different genodermatosis, hereditary or acquired, characterized by skin fragility and subsequent formation of blisters in response to mechanical trauma, and which may also affect mucous membranes. This study aimed to analyze the relation between the nutritional, hematologic, infectious characteristics and the type of epidermolysis bullosa, through a descriptive case study based on data from medical records of 10 patients with epidermolysis bullosa assisted regularly at the Dermatology Clinic of the Hospital Universitário de Brasília. The old classification of the type of epidermolysis bullosa, weight and height, blood count, white blood cell count, platelet count and description of the type and frequency of secondary infections during the service were considered. We verified a predominance of iron deficiency anemia, chronic leukocytosis, thrombocytosis, chronic malnutrition, low height for age and thinness, and people with epidermolysis bullosa simplex exhibited appropriate relation between height/age and BMI/age. The non-specific skin infection was the most prevalent in both sexes. The severity of the type of epidermolysis bullosa and frequency of secondary infections did not form a directly proportional relation. The absence of direct proportion in all cases between the type of epidermolysis bullosa and the analysis parameters suggest a possible significant interference from other aspects such as the extent of the affected skin area, extracutaneous type of engagement and specific genetic mutation. The inclusion of these factors in the new classification proposed by Fine et al can contribute significantly to a better correlation of clinical parameters and appropriate preventive and therapeutic approaches.
authors.affiliation: Universidade de Brasília, Brasília, DF, Brazil.
authors.forename: Márcia Carolline dos Santos
authors.initials: MC
authors.lastname: Sousa
authors.affiliation: Universidade de Brasília, Brasília, DF, Brazil.
authors.forename: Carmen Dea Ribeiro de
authors.initials: CD
authors.lastname: Paula
authors.affiliation: Universidade de Brasília, Brasília, DF, Brazil.
authors.forename: Pedro Luiz
authors.initials: PL
authors.lastname: Tauil
authors.affiliation: Universidade de Brasília, Brasília, DF, Brazil.
authors.forename: Izelda Maria Carvalho
authors.initials: IM
authors.lastname: Costa
mesh_terms: D000293:Adolescent; D001772:Blood Cell Count; D015992:Body Mass Index; D049628:Body Size; D001938:Brazil; D002648:Child; D004820:Epidermolysis Bullosa / Q000097:blood / Q000145:classification* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007239:Infections / Q000503:physiopathology*; D008297:Male; D044342:Malnutrition / Q000503:physiopathology; D009752:Nutritional Status / Q000502:physiology*; D012720:Severity of Illness Index; D013997:Time Factors; D055815:Young Adult