title: In vitro study of an intra-aortic VAD: Effect of reverse-rotating mode on ventricular recovery.
abstract: Cardiac recovery has been observed in end-stage heart failure patients with mechanical circulatory support. An intra-aortic ventricular assist device (IntraVAD) is a novel rotary blood pump designed to operate in the ascending aorta behind the aortic valve, working in series with the compromised left ventricle (LV). Such a device requires optimal motion control in order to enhance the myocardial perfusion and thus promote cardiac recovery. Therefore, a reverse-rotating control (RRc) mode has been proposed to increase the mean arterial pressure (MAP) in diastole where the most coronary flow occurs. The RRc mode consists of two motions - forward rotating speed (FS) and reversely rotating speed (RS). The capability of cardiac recovery of three control modes, including `continuous', `on/off ' and `RRc' modes, was evaluated in vitro. Stroke work (SW), ventricular volume, coronary perfusion pressure (CPP), and arterial pulsatility index (API) were used to evaluate LV unloading, myocardial perfusion and arterial pulsatility. The results show that, all three modes increased the LV stroke work (0.98W vs 1.00W vs 1.01W for continuous, on/off and RRc, respectively; baseline 0.9W) and decreased both end-diastolic volume (EDV) and end-systolic volume (ESV). The "RRc" mode improved CPP significantly (78.4 mm Hg compared to 66.4 mmHg and 70.9 mm Hg for continuous and on/off modes; baseline 71 mm Hg). The arterial pulsatility was higher in `RRc' mode (0.84 compared to 0.43 and 0.59; baseline 0.48). In summary, the IntraVAD operating in the RRc mode can successfully unload the LV, enhance the myocardial perfusion, and restore the arterial pulsatility; therefore, it could be a promising therapeutic option to bridge heart failure patients to recovery.
authors.lastname: Yaxin Wang
authors.lastname: Po-Lin Hsu
authors.forename: Holley C
authors.initials: HC
authors.lastname: Love
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Timms
authors.forename: Richard A
authors.initials: RA
authors.lastname: McMahon
mesh_terms: D001011:Aorta / Q000503:physiopathology*; D001021:Aortic Valve / Q000503:physiopathology; D062186:Arterial Pressure; D003971:Diastole; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy*; D006352:Heart Ventricles / Q000503:physiopathology; D006353:Heart-Assist Devices; D006801:Humans; D008954:Models, Biological; D016277:Ventricular Function, Left