title: Simulation of cellular changes on Optical Coherence Tomography of human retina.
abstract: We present a methodology to assess cell level alterations on the human retina responsible for functional changes observable in the Optical Coherence Tomography data in healthy ageing and in disease conditions, in the absence of structural alterations. The methodology is based in a 3D multilayer Monte Carlo computational model of the human retina. The optical properties of each layer are obtained by solving the Maxwell's equations for 3D domains representative of small regions of those layers, using a Discontinuous Galerkin Finite Element Method (DG-FEM). Here we present the DG-FEM Maxwell 3D model and its validation against Mie's theory for spherical scatterers. We also present an application of our methodology to the assessment of cell level alterations responsible for the OCT data in Diabetic Macular Edema. It was possible to identify which alterations are responsible for the changes observed in the OCT scans of the diseased groups.
authors.forename: Miriam
authors.initials: M
authors.lastname: Santos
authors.forename: Aderito
authors.initials: A
authors.lastname: Araujo
authors.forename: Silvia
authors.initials: S
authors.lastname: Barbeiro
authors.forename: Francisco
authors.initials: F
authors.lastname: Caramelo
authors.forename: Antonio
authors.initials: A
authors.lastname: Correia
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: Marques
authors.forename: Luis
authors.initials: L
authors.lastname: Pinto
authors.forename: Pedro
authors.initials: P
authors.lastname: Serranho
authors.forename: Rui
authors.initials: R
authors.lastname: Bernardes
authors.forename: Miguel
authors.initials: M
authors.lastname: Morgado
mesh_terms: D000368:Aged; D003930:Diabetic Retinopathy / Q000175:diagnosis; D006801:Humans; D008269:Macular Edema; D008962:Models, Theoretical; D012160:Retina / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence