title: Intrinsic Risk Factors of Lateral Ankle Sprain: A Systematic Review and Meta-analysis.
abstract: BACKGROUND
  Lateral ankle ligamentous sprain (LAS) is one of the most common injuries in recreational activities and competitive sports. Many studies have attempted to determine whether there are certain intrinsic factors that can predict LAS. However, no consensus has been reached on the predictive intrinsic factors.
  
  
  OBJECTIVE
  To identify the intrinsic risk factors of LAS by meta-analysis from data in randomized control trials and prospective cohort studies.
  
  
  METHODS
  A systematic computerized literature search of MEDLINE, CINAHL, ScienceDirect, SPORTDiscus, and Cochrane Register of Clinical Trials was performed.
  
  
  METHODS
  A computerized literature search from inception to January 2015 resulted in 1133 studies of the LAS intrinsic risk factors written in English.
  
  
  METHODS
  Systematic review.
  
  
  METHODS
  Level 4.
  
  
  METHODS
  The modified quality index was used to assess the quality of the design of the papers and the standardized mean difference was used as an index to pool included study outcomes.
  
  
  RESULTS
  Eight articles were included in this systematic review. Meta-analysis results showed that body mass index, slow eccentric inversion strength, fast concentric plantar flexion strength, passive inversion joint position sense, and peroneus brevis reaction time correlated with LAS.
  
  
  CONCLUSIONS
  Body mass index, slow eccentric inversion strength, fast concentric plantar flexion strength, passive inversion joint position sense, and the reaction time of the peroneus brevis were associated with significantly increased risk of LAS.
authors.forename: Takumi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Masashi
authors.initials: M
authors.lastname: Tanaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shida
mesh_terms: D016512:Ankle Injuries / Q000209:etiology* / Q000503:physiopathology; D000843:Ankle Joint / Q000502:physiology / Q000503:physiopathology; D015992:Body Mass Index; D006801:Humans; D017844:Lateral Ligament, Ankle / Q000293:injuries*; D053580:Muscle Strength / Q000502:physiology; D011187:Posture / Q000502:physiology; D011434:Proprioception / Q000502:physiology; D016059:Range of Motion, Articular / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012307:Risk Factors; D013180:Sprains and Strains / Q000209:etiology* / Q000503:physiopathology