title: Aging Biology in the Kidney.
abstract: The notion that kidney function declines with age in the general population is well known in the Nephrology community and the average loss of glomerular filtration rate (GFR) about 1ml per year in most longitudinal studies. There is much debate within the community about whether this represents "normal aging" or whether this constitutes a form of renal disease. However this debate turns out, the real question is whether this decline is preventable - can it be modified or slowed? Efforts to find drivers of this decline are still in the very earliest stages, but have shown some promise at elucidating some of the pathologies involved. This article will address both the wider issue of the biology of aging as well as the specific pathologies of the aging kidney.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI; and Division of Geriatrics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
authors.forename: Markus
authors.initials: M
authors.lastname: Bitzer
authors.affiliation: Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI; and Division of Geriatrics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI. Electronic address: wiggi@umich.edu.
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Wiggins
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D004249:DNA Damage; D044127:Epigenesis, Genetic; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D051437:Renal Insufficiency / Q000235:genetics / Q000503:physiopathology* / Q000517:prevention & control; D015398:Signal Transduction