title: Organocatalytic Enantioselective Vinylogous Aldol Reaction of Allyl Aryl Ketones to Activated Acyclic Ketones.
abstract: The first catalytic asymmetric vinylogous aldol reaction of activated allyls to activated acyclic ketones is disclosed. A variety of activated acyclic ketones, such as trifluoromethyl ketones, α-ketoesters, and α-keto phosphonates, were found to be involved forming diverse γ-selective aldol adducts with high enantioselectivities (up to >99% ee). The method provides an effective, general strategy to access valuable chiral electron-withdrawing group-substituted tertiary hydroxyl-based carboxylic acids.
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Jinming Campus, Kaifeng, Henan 475004, China.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Jing
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Jinming Campus, Kaifeng, Henan 475004, China.
authors.forename: Xiangbin
authors.initials: X
authors.lastname: Bai
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Jinming Campus, Kaifeng, Henan 475004, China.
authors.forename: Wenchao
authors.initials: W
authors.lastname: Chen
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Jinming Campus, Kaifeng, Henan 475004, China.
authors.forename: Gao
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Jinming Campus, Kaifeng, Henan 475004, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Jinming Campus, Kaifeng, Henan 475004, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Jiang