title: Receiver Operating Characteristic Curve Analysis of Screening Tools for Bipolar Disorder Comorbid With ADHD in Schoolchildren.
abstract: Objective:We compared Child Behavior Checklist (CBCL)-AAA (Attention Problems, Aggressive Behavior, and Anxious/Depressed) and Parent-Young Mania Rating Scale (P-YMRS) profiles in Brazilian children with ADHD, pediatric-onset bipolar disorder (PBD), and PBD + ADHD.Method:Following analyses of variance or Kruskal-Wallis tests with multiple-comparison Least Significant Difference (LSD) or Dunn's Tests, thresholds were determined by Mann-WhitneyUTests and receiver operating characteristic (ROC) plots.Results:Relative to ADHD, PBD and PBD + ADHD groups scored higher on the Anxious/Depressed, Thought Problems, Rule-Breaking, and Aggressive Behavior subscales and Conduct/Delinquency Diagnostic Scale of the CBCL; all three had similar attention problems. The PBD and PBD + ADHD groups scored higher than the ADHD and healthy control (HC) groups on all CBCL problem scales. The AAA-profile ROC had good diagnostic prediction of PBD + ADHD. PBD and PBD-ADHD were associated with (similarly) elevated P-YMRS scores.Conclusion:The CBCL-PBD and P-YMRS can be used to screen for manic behavior and assist in differential diagnosis.
authors.affiliation: University of California, Los Angeles, USA.|Pelé Pequeno Príncipe Research Institute, Curitiba, Brazil.|Faculdades Pequeno Príncipe, Curitiba, Brazil.
authors.forename: Mara L
authors.initials: ML
authors.lastname: Cordeiro
authors.affiliation: Pelé Pequeno Príncipe Research Institute, Curitiba, Brazil.|Children's Hospital Pequeno Príncipe, Curitiba, Brazil.
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Farias
authors.affiliation: University of California, Los Angeles, USA.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Whybrow
authors.affiliation: Santa Catarina State University, Florianópolis, Brazil.
authors.forename: Erico P G
authors.initials: EPG
authors.lastname: Felden
authors.affiliation: Pelé Pequeno Príncipe Research Institute, Curitiba, Brazil.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Cunha
authors.affiliation: Pelé Pequeno Príncipe Research Institute, Curitiba, Brazil.
authors.forename: Vilmar
authors.initials: V
authors.lastname: da Veiga
authors.affiliation: Pelé Pequeno Príncipe Research Institute, Curitiba, Brazil.
authors.forename: Cássia R
authors.initials: CR
authors.lastname: Benko
authors.affiliation: University of California, Los Angeles, USA.
authors.forename: James T
authors.initials: JT
authors.lastname: McCracken
mesh_terms: D000374:Aggression; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000453:epidemiology; D001714:Bipolar Disorder / Q000175:diagnosis / Q000453:epidemiology; D057189:Checklist; D002648:Child; D006801:Humans; D012372:ROC Curve
keywords: ADHD; bipolar; diagnostic validity; receiver operating characteristic