title: Long Noncoding RNAs: An Overview.
abstract: Recently an explosion in the discovery of long noncoding RNAs (lncRNAs) was obtained by high throughput sequencing. Genome-wide transcriptome analyses, in conjugation with research for epigenetic modifications of chromatins, identified a novel type of non-protein-coding transcripts longer than 200 nucleotides named lncRNAs. They are gradually emerging as functional and critical participants in many physiological processes. Here we give an overview of the characteristics, biological functions, and working mechanism for this new class of noncoding factors.
authors.affiliation: State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Biology, Zhongshan School of Medicine, Center for Stem Cell Biology and Tissue Engineering, Sun Yat-Sen University, Guangzhou, 510080, China.
authors.forename: Minmin
authors.initials: M
authors.lastname: Xiong
authors.affiliation: Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200011, China.
authors.forename: Congjian
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Biology, Zhongshan School of Medicine, Center for Stem Cell Biology and Tissue Engineering, Sun Yat-Sen University, Guangzhou, 510080, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xiang
authors.affiliation: Department of Biology, Zhongshan School of Medicine, Center for Stem Cell Biology and Tissue Engineering, Sun Yat-Sen University, Guangzhou, 510080, China. zhongxm23@mail.sysu.edu.cn.|Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200011, China. zhongxm23@mail.sysu.edu.cn.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Zhong
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming; D044127:Epigenesis, Genetic; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D062085:RNA, Long Noncoding / Q000235:genetics*; D013234:Stem Cells / Q000378:metabolism; D049951:X Chromosome Inactivation
chemical_list: D062085:RNA, Long Noncoding
keywords: Cancer; Epigenetic; Long noncoding RNAs; Stem cell