title: Aplasia Cutis Congenita in a Newborn Child Associated with Two Fetus Papyraceous.
abstract: Aplasia cutis congenita (ACC) is a rare inborn lesion, presenting with absence of skin. The etiology is unknown and is probably not attributable to a single cause but to a combination of genetic factors. Multiple causes have been suggested for ACC: syndromes and teratogens, intrauterine infection--varicella zoster virus, herpes simplex virus--fetal exposure to cocaine, heroin, alcohol, or antithyroid drugs. The most common site is the scalp. We report a case with multiple lesions on the trunk, resembling an instance with ACC group 5. This form of ACC occurs in association with the in utero death of a twin or more (in this case triple) fetus. Histological findings are available in very few reports. Therapy options depend on the characteristics of the lesion, but conservative treatment is usually chosen.
authors.affiliation: Dubravka Šimić, MD, PhD, Clinic for Dermatology and Venereology, University Clinical Hospital , 88 000 Mostar, Kralja Tvrtka bb, Bosnia and Herzegovina; simicdubravka@gmail.com.
authors.forename: Dubravka
authors.initials: D
authors.lastname: Šimić
authors.forename: Asja
authors.initials: A
authors.lastname: Prohić
authors.forename: Neira
authors.initials: N
authors.lastname: Puizina Ivić
authors.forename: Jasna
authors.initials: J
authors.lastname: Zeljko Penavić
authors.forename: Teo
authors.initials: T
authors.lastname: Tomić
mesh_terms: D004476:Ectodermal Dysplasia / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D005313:Fetal Death; D006801:Humans; D007231:Infant, Newborn; D008297:Male