title: Immunoglobulin G (IgG) Subtype Is Associated with a Favorable Survival Prognosis in Patients Irradiated for Spinal Cord Compression from Myeloma.
abstract: OBJECTIVE
  This study was performed to investigate the prognostic impact of the myeloma subtype on the survival prognosis of patients with spinal cord compression (SCC) from myeloma.
  
  
  METHODS
  In 238 patients irradiated for SCC from myeloma, the myeloma subtype and 10 additional characteristics were evaluated for survival. These characteristics were fractionation of radiotherapy, age, time from myeloma diagnosis to SCC, presence of extra-osseous lesions, additional osseous lesions, gender, time to developing motor weakness, ability to walk, number of vertebrae affected by SCC and performance status.
  
  
  RESULTS
  Immunoglobulin G subtype was associated with significantly better survival than other subtypes both at 1 year (80% vs. 50%) and at 2 years (56% vs. 30%) following radiotherapy of SCC (p<0.001). In the subsequent Cox regression analysis, myeloma subtype maintained significance (risk ratio=2.44; 95% confidence interval=1.56-3.85; p<0.001).
  
  
  CONCLUSIONS
  This study identified myeloma subtype as being an independent prognostic factor of survival in patients with SCC from myeloma.
authors.affiliation: Department of Radiation Oncology, University of Lübeck, Lübeck, Germany Rades.Dirk@gmx.net.
authors.forename: Dirk
authors.initials: D
authors.lastname: Rades
authors.affiliation: Department of Radiation Oncology, Consorcio Hospital Provincial de Castellón, Castellón, Spain.
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Conde-Moreno
authors.affiliation: Department of Medical Oncology, University of Lübeck, Lübeck, Germany.
authors.forename: Niklas
authors.initials: N
authors.lastname: Gebauer
authors.affiliation: Department of Medical Oncology, University of Lübeck, Lübeck, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Bartscht
authors.affiliation: Department of Radiation Oncology, Cruces University Hospital, Barakaldo, Vizcaya, Spain.
authors.forename: Jon
authors.initials: J
authors.lastname: Cacicedo
authors.affiliation: Department of Radiotherapy, Ljubljana Institute of Oncology, Ljubljana, Slovenia.
authors.forename: Barbara
authors.initials: B
authors.lastname: Segedin
authors.affiliation: Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.
authors.forename: Steven E
authors.initials: SE
authors.lastname: Schild
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000401:mortality; D011379:Prognosis; D013117:Spinal Cord Compression / Q000401:mortality / Q000532:radiotherapy*; D016019:Survival Analysis
chemical_list: D007074:Immunoglobulin G
keywords: Immunoglobulin G; myeloma; radiotherapy; spinal cord compression; survival