title: Development of a Rapid Cartilage Damage Quantification Method for the Lateral Tibiofemoral Compartment Using Magnetic Resonance Images: Data from the Osteoarthritis Initiative.
abstract: The purpose of this study was to expand and validate the cartilage damage index (CDI) to detect cartilage damage in the lateral tibiofemoral compartment. We used an iterative 3-step process to develop and validate the lateral CDI: development (100 knees), testing (80 knees), and validation (100 knees). The validation set included 100 knees from the Osteoarthritis Initiative that was enriched to include all grades of lateral joint space narrowing (JSN, 0-3). Measurement of the CDI was rapid at 7.4 (s.d. 0.73) minutes per knee pair (baseline and follow-up of one knee). The intratester reliability is good (intraclass correlation coefficient (3, 1 model) = 0.86 to 0.98). At baseline, knees with greater KL grade and lateral JSN had a lower mean CDI (i.e., greater cartilage damage). Baseline lateral CDI is associated with both lateral JSW (r = 0.81 to 0.85, p < 0.01) and HKA (r = -0.30 to -0.33, p < 0.05). The SRM is good (lateral femur SRM = -0.76; lateral tibia SRM = -0.73; lateral tibiofemoral total SRM = -0.87). The lateral tibiofemoral CDI quantification allows for rapid evaluation and is reliable and responsive, with good construct validity. It may be an efficient method to measure lateral tibiofemoral articular cartilage in large clinical and epidemiologic studies.
authors.affiliation: Division of Rheumatology, Tufts Medical Center, 800 Washington Street, P.O. Box 406, Boston, MA 02111, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Division of Rheumatology, Tufts Medical Center, 800 Washington Street, P.O. Box 406, Boston, MA 02111, USA.
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Driban
authors.affiliation: The Institute for Clinical Research and Health Policy Studies, 800 Washington Street, P.O. Box 63, Boston, MA 02111, USA ; Tufts Medical Center and Tufts Clinical and Translational Science Institute, Tufts University, 800 Washington Street, P.O. Box 63, Boston, MA 02111, USA.
authors.forename: Lori Lyn
authors.initials: LL
authors.lastname: Price
authors.affiliation: Medical Care Line and Research Care Line, Houston Health Services Research and Development (HSR&D) Center of Excellence Michael E. DeBakey VAMC, Houston, TX 77030, USA ; Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, 1 Baylor Plaza, BCM-285, Houston, TX 77030, USA.
authors.forename: Grace H
authors.initials: GH
authors.lastname: Lo
authors.affiliation: Department of Electrical and Computer Engineering, Tufts University, 216 Halligan Hall, Medford, MA 02155, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Miller
authors.affiliation: Division of Rheumatology, Tufts Medical Center, 800 Washington Street, P.O. Box 406, Boston, MA 02111, USA.
authors.forename: Timothy E
authors.initials: TE
authors.lastname: McAlindon
mesh_terms: D000368:Aged; D002358:Cartilage, Articular / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging* / Q000473:pathology; D011859:Radiography; D012720:Severity of Illness Index; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology