title: Validation of the Generalized Anxiety Disorder-7 (GAD-7) among Chinese people with epilepsy.
abstract: OBJECTIVE
  To validate the Chinese version of the Generalized Anxiety Disorder-7 (GAD-7) in Chinese people with epilepsy (PWE).
  
  
  METHODS
  A consecutive cohort of PWE from the West China Hospital was recruited. Each patient received a psychiatric evaluation comprising the Mini International Neuropsychiatric Interview (MINI) and the GAD-7. Demographic and clinical characteristics were collected. Cronbach's α coefficient was calculated and receiver operating curve (ROC) analysis was conducted.
  
  
  RESULTS
  A total of 213 PWE completed the psychiatric evaluation. The GAD-7 was easily understood and quickly completed by all participants. Fifty patients (23.5%) had GAD according to the MINI criteria. Cronbach's α coefficient for the GAD-7 was 0.888. ROC analysis showed an area under the curve of 0.974 (95% CI=0.956-0.993). At a cut-off score of >6, the GAD-7 achieved the largest Youden index of 0.854 with a sensitivity of 94%, a specificity of 91.4%, a positive predictive value of 77% and a negative predictive value of 98%.
  
  
  CONCLUSIONS
  The Chinese version of the GAD-7 is a valuable tool for screening for GAD in Chinese PWE.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Tong
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China. Electronic address: zhoudong66@yahoo.de.
authors.forename: Dongmei
authors.initials: D
authors.lastname: An
authors.affiliation: Aix Marseille Université, Inserm, INS UMR_S 1106, CHU Timone, Service de Neurophysiologie Clinique, Assistance Publique des Hôpitaux de Marseille, Marseille 13005, France.
authors.forename: Aileen
authors.initials: A
authors.lastname: McGonigal
authors.affiliation: Department of Neurology, School of Medicine, Kyungpook National University, Daegu, South Korea.
authors.forename: Sung-Pa
authors.initials: SP
authors.lastname: Park
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001008:Anxiety Disorders / Q000150:complications* / Q000175:diagnosis*; D002681:China; D015331:Cohort Studies; D004827:Epilepsy / Q000150:complications* / Q000523:psychology; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D007802:Language; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012372:ROC Curve; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Anxiety; China; Epilepsy; GAD-7; Screening; Validation