title: Effect of Randomized Clinical Trial Findings on Emergency Management.
abstract: OBJECTIVE
  Research findings are not consistently adopted in the clinical setting and there is a gap between best evidence and clinical practice across a range of conditions and settings. A number of factors may contribute to this discrepancy, including the direction of the research findings (i.e., whether positive or negative for an intervention). The objectives of this study were to measure the translation of results from randomized controlled trials (RCTs) into clinical care and to determine whether the direction of the trial findings influence the uptake of research reports into clinical practice.
  
  
  METHODS
  This was a retrospective study of clinical care provided in emergency departments (EDs) across the United States with data collected by the National Hospital Ambulatory Medical Care Survey from 1992 to 2010. RCTs published in journals with the highest impact factors and conducted in ED settings were selected and data were extracted on the interventions under study, the patient populations examined, and the trial findings. Changes in clinical practice corresponding to the RCT results were measured by comparing the rates of treatment with the intervention during the 3-year period before and after publication of the trial.
  
  
  RESULTS
  Twenty-one RCTs met the inclusion criteria. Ten studies reported positive interventions, of which nine (90%) were associated with an increased ED use of the intervention after trial publication. Four studies showing the lack of benefit of interventions were not used in ED practice prior to the trial and practice did not change in the postpublication period. The remaining eight trials presented negative findings or results comparing two different interventions, and of these, three (38%) were associated with small changes in the ED use of the interventions, consistent with the trial results.
  
  
  CONCLUSIONS
  In the ED setting, results of RCTs published in high-impact journals are more likely to be translated into clinical care when they demonstrate the benefits of an intervention. Our findings indicate that direction of research evidence is an important factor when evaluating knowledge uptake into clinical practice.
authors.affiliation: Division of Emergency Medicine, Boston Children's Hospital, Boston, MA.|Department of Pediatrics, Harvard Medical School, Boston, MA.
authors.forename: Joel D
authors.initials: JD
authors.lastname: Hudgins
authors.affiliation: Division of Emergency Medicine, Boston Children's Hospital, Boston, MA.|Department of Pediatrics, Harvard Medical School, Boston, MA.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Fine
authors.affiliation: Division of Emergency Medicine, Boston Children's Hospital, Boston, MA.|Department of Pediatrics, Harvard Medical School, Boston, MA.
authors.forename: Florence T
authors.initials: FT
authors.lastname: Bourgeois
mesh_terms: D004632:Emergency Medical Services / Q000592:standards*; D004638:Emergency Treatment / Q000592:standards*; D005260:Female; D006801:Humans; D010043:Outcome and Process Assessment, Health Care; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D014481:United States