title: Calcium leak induced arrhythmias in mouse sino-atrial node and ventricle cells: A simulation study.
abstract: Bradycardia is found to be a complication during catecholaminergic polymorphic ventricular tachycardia in which calcium leak plays a pivotal role. In this computational study, we determined the effects of sarcoplasmic reticulum calcium leak on the function of sino-atrial node and ventricular model cells.
authors.forename: Qingjie
authors.initials: Q
authors.lastname: Wang
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kharche
authors.forename: Gareth
authors.initials: G
authors.lastname: Jones
authors.forename: Cunjin
authors.initials: C
authors.lastname: Luo
authors.forename: Chengchun
authors.initials: C
authors.lastname: Tang
authors.forename: Henggui
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac; D002118:Calcium; D051379:Mice; D019837:Ryanodine Receptor Calcium Release Channel; D012519:Sarcoplasmic Reticulum; D012849:Sinoatrial Node; D017180:Tachycardia, Ventricular
chemical_list: D019837:Ryanodine Receptor Calcium Release Channel; D002118:Calcium