title: FRMD3 gene: its role in diabetic kidney disease. A narrative review.
abstract: Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus, which is considered a worldwide epidemic. Several studies have been developed in order to elucidate possible genetic factors involved in this disease. The FRMD3 gene, a strong candidate selected from genome wide association studies (GWAS), encodes the structural protein 4.1O involved in maintaining cell shape and integrity. Some single nucleotide polymorphisms (SNPs) located in FRMD3 have been associated with DKD in different ethnicities. However, despite these findings, the matter is still controversial. The aim of this narrative review is to summarize the evidence regarding the role of FRMD3 in DKD.
authors.affiliation: Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, prédio 12, 4° andar, Porto Alegre, RS 90035-003 Brazil ; Endocrinology, Federal University of Rio Grande do Sul, Porto Alegre, RS Brazil ; Federal University of Rio Grande do Sul, Porto Alegre, RS Brazil.
authors.forename: Marjoriê Piuco
authors.initials: MP
authors.lastname: Buffon
authors.affiliation: Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, prédio 12, 4° andar, Porto Alegre, RS 90035-003 Brazil ; Endocrinology, Federal University of Rio Grande do Sul, Porto Alegre, RS Brazil ; Federal University of Rio Grande do Sul, Porto Alegre, RS Brazil.
authors.forename: Denise Alves
authors.initials: DA
authors.lastname: Sortica
authors.affiliation: Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, prédio 12, 4° andar, Porto Alegre, RS 90035-003 Brazil ; Endocrinology, Federal University of Rio Grande do Sul, Porto Alegre, RS Brazil ; Federal University of Rio Grande do Sul, Porto Alegre, RS Brazil.
authors.forename: Fernando
authors.initials: F
authors.lastname: Gerchman
authors.affiliation: Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, prédio 12, 4° andar, Porto Alegre, RS 90035-003 Brazil ; Endocrinology, Federal University of Rio Grande do Sul, Porto Alegre, RS Brazil.
authors.forename: Daisy
authors.initials: D
authors.lastname: Crispim
authors.affiliation: Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, prédio 12, 4° andar, Porto Alegre, RS 90035-003 Brazil ; Endocrinology, Federal University of Rio Grande do Sul, Porto Alegre, RS Brazil ; Federal University of Rio Grande do Sul, Porto Alegre, RS Brazil.
authors.forename: Luís Henrique
authors.initials: LH
authors.lastname: Canani