title: New genetic mechanism, origin and population dynamic of bovine ephemeral fever virus.
abstract: Bovine ephemeral fever virus (BEFV) is a typical species of the genusEphemerovirus in the family Rhabdoviridae. Today, prevailing BEFV can be divided into three phylogeographic lineages, East Asia, Mideast, and Australia. In this study, we provide evidence that the whole East Asia lineage originates from a homologous recombination (HR) between the Mideast and Australia lineages that probably occurred in the 1940s. To our knowledge, HR has not been proposed before as the genetic mechanism of BEFV. According to the HR event and Bayesian estimation, the three BEFV lineages might originate from Africa, and may have spread to Asia and Australia through the Mideast. In addition, the population of the virus may have augmented significantly in the 2000s, suggesting that the risk for outbreaks of BEFV may be high at present.
authors.affiliation: College of Life Science, Shandong Normal University, Jinan 250014, China.
authors.forename: Cheng-Qiang
authors.initials: CQ
authors.lastname: He
authors.affiliation: College of Life Science, Shandong Normal University, Jinan 250014, China.
authors.forename: Ya-Xin
authors.initials: YX
authors.lastname: Liu
authors.affiliation: Dairy Cattle Research Center, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Wang
authors.affiliation: Dairy Cattle Research Center, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
authors.forename: Pei-Li
authors.initials: PL
authors.lastname: Hou
authors.affiliation: Dairy Cattle Research Center, Shandong Academy of Agricultural Sciences, Jinan 250100, China. Electronic address: hongbinh@hotmail.com.
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: He
authors.affiliation: College of Life Science, Shandong Normal University, Jinan 250014, China. Electronic address: nzding@sdnu.edu.cn.
authors.forename: Nai-Zheng
authors.initials: NZ
authors.lastname: Ding
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002417:Cattle; D004810:Ephemeral Fever / Q000453:epidemiology / Q000821:virology*; D018115:Ephemeral Fever Virus, Bovine / Q000235:genetics*; D005202:Asia, Eastern / Q000453:epidemiology; D014943:Global Health; D010802:Phylogeny
keywords: Bovine ephemeral fever virus; Genetic diversity; Homologous recombination