title: High-pressure high-temperature phase diagram of organic crystal paracetamol.
abstract: High-pressure high-temperature (HPHT) Raman spectroscopy studies have been performed on the organic crystal paracetamol in a diamond anvil cell utilizing boron-doped heating diamond anvil. Isobaric measurements were conducted at pressures up to 8.5 GPa and temperature up to 520 K in five different experiments. Solid state phase transitions from monoclinic Form I  →  orthorhombic Form II were observed at various pressures and temperatures as well as transitions from Form II  →  unknown Form IV. The melting temperature for paracetamol was observed to increase with increasing pressures to 8.5 GPa. This new data is combined with previous ambient temperature high-pressure Raman and x-ray diffraction data to create the first HPHT phase diagram of paracetamol.
authors.affiliation: Department of Physics, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.
authors.forename: Spencer J
authors.initials: SJ
authors.lastname: Smith
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Montgomery
authors.forename: Yogesh K
authors.initials: YK
authors.lastname: Vohra