title: Pathogenic Acinetobacter: from the Cell Surface to Infinity and Beyond.
abstract: The genus Acinetobacter encompasses multiple nosocomial opportunistic pathogens that are of increasing worldwide relevance because of their ability to survive exposure to various antimicrobial and sterilization agents. Among these, Acinetobacter baumannii, Acinetobacter nosocomialis, and Acinetobacter pittii are the most frequently isolated in hospitals around the world. Despite the growing incidence of multidrug-resistant Acinetobacter spp., little is known about the factors that contribute to pathogenesis. New strategies for treating and managing infections caused by multidrug-resistant Acinetobacter strains are urgently needed, and this requires a detailed understanding of the pathobiology of these organisms. In recent years, some virulence factors important for Acinetobacter colonization have started to emerge. In this review, we focus on several recently described virulence factors that act at the bacterial surface level, such as the capsule, O-linked protein glycosylation, and adhesins. Furthermore, we describe the current knowledge regarding the type II and type VI secretion systems present in these strains.
authors.affiliation: Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
authors.forename: Brent S
authors.initials: BS
authors.lastname: Weber
authors.affiliation: Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
authors.forename: Christian M
authors.initials: CM
authors.lastname: Harding
authors.affiliation: Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA mariofeldman@wustl.edu.
authors.forename: Mario F
authors.initials: MF
authors.lastname: Feldman
mesh_terms: D000150:Acinetobacter / Q000187:drug effects / Q000472:pathogenicity*; D000151:Acinetobacter Infections / Q000453:epidemiology / Q000382:microbiology*; D018829:Adhesins, Bacterial / Q000378:metabolism; D016667:Bacterial Capsules / Q000378:metabolism; D058947:Bacterial Secretion Systems; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D019081:O Antigens / Q000378:metabolism; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D018829:Adhesins, Bacterial; D058947:Bacterial Secretion Systems; D019081:O Antigens; D037521:Virulence Factors