title: Small Cell Carcinoma of the Esophagus: Clinicopathological Features and Outcome of 22 Cases.
abstract: BACKGROUND
  Small cell esophageal carcinoma (SCEC) is a highly aggressive and rare neoplasm.
  
  
  OBJECTIVE
  This study aimed to report the characteristics, prognostic factors, and treatment outcomes of 22 patients with SCEC.
  
  
  METHODS
  This brief report was carried out by reviewing the medical records of 22 patients with newly histologically proven SCEC that were treated between 2000 and 2010 at 2 tertiary academic hospitals. All the potential prognostic variables, including the patients' characteristics, tumor features, and treatment modalities were analyzed to establish their influence on the patients' survival rates.
  
  
  RESULTS
  This study was conducted on 7 males and 15 females with a median age of 61 years. Dysphagia and weight loss were the most prevalent symptoms. According to the results, 14 patients (64%) had limited diseases and 8 cases (36%) had extensive diseases. In those with extensive diseases, liver, lung, and lymph nodes (LNs) were the most metastatic sites. Besides, most tumors were located in lower (50%) and middle (32%) part of the esophagus. Most patients (91%) were treated with sequential (55%) or concurrent (36%) chemoradiation (CRT). Surgical resection was also performed for 7 patients. Chemotherapy regimen consisted of cisplatin and etoposide in 14 patients (64%). The median follow up time was 12 months. The 1, 3, and 5-year overall survival rates were 27%, 14%, and 4%, respectively. Yet, no prognostic factors were found because of the small sample size of the study.
  
  
  CONCLUSIONS
  Primary SCEC is a rare and highly aggressive tumor. However, prognosis is poor and long-term survival is exceptional. CRT could be an appropriate alternative to operation.
authors.affiliation: Cancer Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.
authors.forename: Sare
authors.initials: S
authors.lastname: Hosseini
authors.affiliation: Cancer Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.
authors.forename: Roham
authors.initials: R
authors.lastname: Salek
authors.affiliation: Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Nasrolahi
authors.affiliation: Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mohammadianpanah
authors.affiliation: Cancer Research Centre, Mashhad University of Medical Sciences, Mashhad, IR Iran.
authors.forename: Mona
authors.initials: M
authors.lastname: Judi
keywords: Chemotherapy; Esophagus; Prognosis; Small Cell Carcinoma; Surgical Procedures