title: Immunohistochemical Assessment of HER3 Expression in Odontogenic Cysts.
abstract: BACKGROUND
  It has been demonstrated that HER3 plays an important role in some human cancers and the HER3 expression is associated with worse survival in solid tumors.
  
  
  OBJECTIVE
  This study was conducted to compare HER3 expression in epithelial lining of radicular cysts (RCs), dentigerous cysts (DCs) and odontogenic keratocysts (OKCs).
  
  
  METHODS
  This was a descriptive-analytical study, which assessed all 57 paraffin blocks of RCs, DCs and OKCs (21 RCs, 16 DCs, 20 OKC) from pathological archive of Dentistry College of Zahedan, Iran. The HER3 expression in cytoplasm and membrane was examined by immunohistochemical method. The data collected was analyzed using SPSS16 by ANOVA and Chi-square. P < 0.05 was considered as statistically significant.
  
  
  RESULTS
  The HER3 expression had positive results in 52.4% of OKC, 50% of DC and only 20% of RC samples. There was a significant difference between HER3 expression in OKCs and RCs.
  
  
  CONCLUSIONS
  The HER3 expression in developmental odontogenic cysts was higher than that in inflammatory odontogenic cysts. The higher rate of HER3 expression in OKC may justify inherent growth potential, stimulation-independent proliferation capability, invasive growth and high recurrence rate of the cyst accepted today as a tumor.
authors.affiliation: Oral and Dental Disease Research Centre, Department of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, IR Iran.
authors.forename: Marieh
authors.initials: M
authors.lastname: Honarmand
authors.affiliation: Oral and Dental Disease Research Centre, Department of Oral and Maxillofacial Pathology, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, IR Iran.
authors.forename: Shirin
authors.initials: S
authors.lastname: Saravani
authors.affiliation: Department of Oral Medicine, School of Dentistry, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran.
authors.forename: Nazanin
authors.initials: N
authors.lastname: Kamyab
authors.affiliation: Department of Pathology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Jahantigh
authors.affiliation: Department of Oral and Maxillofacial Pathology, School of Dentistry, Kerman University of Medical Sciences, Kerman, IR Iran.
authors.forename: Molouk
authors.initials: M
authors.lastname: Torabi Parizi
keywords: Dentigerous Cyst; Human Epidermal Growth Factor Receptor3; Odontogenic Cysts; Radicular Cyst