title: A NOVEL FLT4 GENE MUTATION AND MR LYMPHANGIOGRAPHY IN A CHINESE FAMILY WITH MILROY DISEASE.
abstract: Milroy disease is a congenital onset lymphedema linked to FLT4 gene mutations in the tyrosine kinase domain. So far, a total of 59 different FLT4 variants have been identified. Here, we report a novel FLT4 gene mutation in a Chinese family with Milroy disease and present their clinical symptoms and MR lymphangiographic findings.
authors.forename: N F
authors.initials: NF
authors.lastname: Liu
authors.forename: Z
authors.initials: Z
authors.lastname: Yu
authors.forename: Y
authors.initials: Y
authors.lastname: Luo
authors.forename: D
authors.initials: D
authors.lastname: Sun
authors.forename: Z
authors.initials: Z
authors.lastname: Yan
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D002675:Child, Preschool; D002681:China; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D040941:Heredity; D006801:Humans; D035002:Lower Extremity / Q000473:pathology*; D008209:Lymphedema / Q000208:ethnology / Q000235:genetics* / Q000473:pathology*; D008220:Lymphography / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D009154:Mutation; D010375:Pedigree; D010641:Phenotype; D011237:Predictive Value of Tests; D040321:Vascular Endothelial Growth Factor Receptor-3 / Q000235:genetics*
chemical_list: C581309:FLT4 protein, human; D040321:Vascular Endothelial Growth Factor Receptor-3