title: Misconstrued versatility of Ganoderma lucidum: a key player in multi-targeted cellular signaling.
abstract: A Basidiomycetes fungus belonging to polypore family of mushrooms, Ganoderma lucidum (GL), has been known since a long time for their myriad therapeutic indications. Renowned as an invaluable resource of cardinal mycoconstituents they encompass numerous terpenoids polysaccharides and proteins. Possessing the therapeutically potent lanosteroidal skeleton, terpenoids are upheld for their invariable participation in therapeutically diverse bioactivities. Polysaccharides and proteins exhibiting distinguishable bioactivities provide this oriental mushroom with additional edges over immune function and anti-cancer potential. This review is a concerted effort to throw light upon the therapeutic versatility of the fungus, shadowed by various other natural products. An effort has been made towards conglomerating the mycoconstituents decisive for the many activities portrayed by this fungus. More importantly, this review seeks to fathom the inextricable role played by derivatives in modulating signaling cascades such as downregulation of various mitogenic pathways, inhibiting growth factors, or upregulating certain pathways enhancing cellular integrity.
authors.affiliation: Centre for Biosciences, Central University of Punjab, Bathinda, 151001, India.
authors.forename: Balraj Singh
authors.initials: BS
authors.lastname: Gill
authors.affiliation: Centre for Biosciences, Central University of Punjab, Bathinda, 151001, India.
authors.forename: Prateek
authors.initials: P
authors.lastname: Sharma
authors.affiliation: Centre for Chemical and Pharmaceutical Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, 151001, India.
authors.forename: Raj
authors.initials: R
authors.lastname: Kumar
authors.affiliation: Centre for Biosciences, Central University of Punjab, Bathinda, 151001, India. sanjeevpuchd@gmail.com.|Centre for Chemical and Pharmaceutical Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, 151001, India. sanjeevpuchd@gmail.com.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Kumar
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology; D011134:Polysaccharides / Q000494:pharmacology; D020940:Reishi / Q000737:chemistry; D015398:Signal Transduction; D013729:Terpenes / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D007155:Immunologic Factors; D011134:Polysaccharides; D013729:Terpenes
keywords: Cancer; Ganoderic acid (GA); Ganoderma lucidum; Polysaccharides; Terpenoids