title: Gestational Gigantomastia Complicating Pregnancy: A Case Report and Review of the Literature.
abstract: Background. Gestational gigantomastia is a rare disorder without clear etiology or well-established risk factors. Several pathogenic mechanisms contributing to the disease process have been proposed, all of which can lead to a similar phenotype of breast hypertrophy. Case. A 28-year-old Guinean woman presented at 37 weeks of gestation with bilateral gigantomastia, mastalgia, peau d'orange, and back pain. Prolactin levels were 103.3 μg/L (with a normal reference value for prolactin in pregnancy being 36-372 μg/L). The patient was treated with bromocriptine (2.5 mg twice daily), scheduled for a repeat cesarean, and referred to surgery for bilateral mammoplasty. Conclusion. Gestational gigantomastia is a rare disorder, characterized by enlargement and hypertrophy of breast tissue. Our patient presented with no endocrine or hematological abnormalities, adding to a review of the literature for differential diagnoses, workup, and management of cases of gestational gigantomastia with normal hormone levels.
authors.affiliation: Department of Obstetrics and Gynecology, Lincoln Medical and Mental Health Center, Bronx, NY 10451, USA.
authors.forename: Shadi
authors.initials: S
authors.lastname: Rezai
authors.affiliation: School of Medicine, St. George's University, West Indies, Grenada.
authors.forename: Jenna T
authors.initials: JT
authors.lastname: Nakagawa
authors.affiliation: School of Medicine, St. George's University, West Indies, Grenada.
authors.forename: John
authors.initials: J
authors.lastname: Tedesco
authors.affiliation: Department of Obstetrics and Gynecology, Lincoln Medical and Mental Health Center, Bronx, NY 10451, USA.
authors.forename: Annika
authors.initials: A
authors.lastname: Chadee
authors.affiliation: Department of Obstetrics and Gynecology, Lincoln Medical and Mental Health Center, Bronx, NY 10451, USA.
authors.forename: Sri
authors.initials: S
authors.lastname: Gottimukkala
authors.affiliation: Department of Obstetrics and Gynecology, Lincoln Medical and Mental Health Center, Bronx, NY 10451, USA.
authors.forename: Ray
authors.initials: R
authors.lastname: Mercado
authors.affiliation: Department of Obstetrics and Gynecology, Lincoln Medical and Mental Health Center, Bronx, NY 10451, USA.
authors.forename: Cassandra E
authors.initials: CE
authors.lastname: Henderson