title: [Poised RNA polymerase II and master regulation in Metazoa].
abstract: This review is devoted to the mechanisms of transcriptional pause and poised state of RNA polymerase II. Features of poised promoters and chromatin are considered in brief. Role of regulated transcriptional pause as discrete and important stage in regulation of master genes that determine stem-cell differentiation, cell lineage and development in Metazoa is discussed. This work was supported by the Russian Science Foundation (project No. 14-50-00131).
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997 Russia.
authors.forename: K N
authors.initials: KN
authors.lastname: Kashkin
authors.forename: E D
authors.initials: ED
authors.lastname: Sverdlov
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D012319:RNA Polymerase II
keywords: RNA polymerase II; chromatin; master regulation; promoter; transcription