title: Association of metabolic complications with plasma mid-regional pro-adrenomedullin level in stable kidney transplant recipients.
abstract: BACKGROUND
  Recently, increased plasma mid-regional pro-adrenomedullin (MR-proADM) concentrations have been demonstrated in patients with chronic renal failure. In this study, we attempted to identify significant clinical factors associated with MR-proADM concentration in stable kidney transplant recipients.
  
  
  METHODS
  Forty-seven Japanese kidney transplant recipients who underwent transplantation >180days prior to the study were analyzed. To facilitate comparability of anti-hypertensive regimens across recipients taking different drugs, we calculated the treatment intensity score of anti-hypertensive drugs in each recipient. Morning blood samples were collected and plasma MR-proADM concentrations were measured using an enzyme immunoassay.
  
  
  RESULTS
  Multiple regression analysis identified treatment intensity score for anti-hypertensive drugs, serum albumin, creatinine clearance and use of lipid-lowering agents as significant independent factors associated with plasma MR-proADM concentration. Adjusted coefficient of determination for this model was 0.46.
  
  
  CONCLUSIONS
  Apart from indicating lowered renal function, plasma MR-proADM concentration may be a useful biomarker for metabolic disorders, especially hypertension and hyperlipidemia, in stable kidney transplant patients.
authors.affiliation: Department of Clinical Pharmacy, Oita University Hospital, Hasama-machi, Oita 879-5593, Japan. Electronic address: y-suzuki@oita-u.ac.jp.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Laboratory of Clinical Biochemistry, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Katagiri
authors.affiliation: Department of Urology, Faculty of Medicine, Oita University, Hasama-machi, Oita 879-5593, Japan.
authors.forename: Fuminori
authors.initials: F
authors.lastname: Sato
authors.affiliation: Department of Clinical Pharmacy, Oita University Hospital, Hasama-machi, Oita 879-5593, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujioka
authors.affiliation: Department of Clinical Pharmacy, Oita University Hospital, Hasama-machi, Oita 879-5593, Japan.
authors.forename: Ryota
authors.initials: R
authors.lastname: Tanaka
authors.affiliation: Department of Clinical Pharmacy, Oita University Hospital, Hasama-machi, Oita 879-5593, Japan.
authors.forename: Yuhki
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Department of Urology, Faculty of Medicine, Oita University, Hasama-machi, Oita 879-5593, Japan.
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Mimata
authors.affiliation: Department of Clinical Pharmacy, Oita University Hospital, Hasama-machi, Oita 879-5593, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Itoh
mesh_terms: D000293:Adolescent; D053607:Adrenomedullin / Q000097:blood*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood* / Q000209:etiology / Q000378:metabolism*; D011498:Protein Precursors / Q000097:blood*; D055815:Young Adult
chemical_list: D011498:Protein Precursors; D053607:Adrenomedullin
keywords: Hyperlipidemia; Hypertension; Kidney transplantation; Metabolic complications; Mid-regional pro-adrenomedullin