title: Association between tumor necrosis factor-α gene polymorphisms and diffuse large B-cell lymphoma in Chinese Han population: evidence from two center case-control study and a meta-analysis.
abstract: OBJECTIVE
  The tumor necrosis factor-α (TNF-α) gene, which plays crucial roles in tumorigenesis, is reported to be an independent marker for cancer. This study aims to examine the association between the TNF-α G308A polymorphism and DLBCL risk based on the two center case-control studies and meta-analysis.
  
  
  METHODS
  In the current study, we performed a two centers case-control study to investigate the effect of the TNF-α G308A polymorphism on DLBCL risk in Chinese Han population. A meta-analysis including 10 published datasets along with current dataset, including 111 comparisons containing 34,041 cases and 42,730 controls were enrolled, was next performed to further confirm the association after literature search was conducted and relevant studies were identified from PubMed, Embase, and Web of Science.
  
  
  RESULTS
  The TNF-α -308A allele was associated with a significantly increased DLBCL risk in the two independent patient case-control studies and additionally for pooled analysis from the two sets (P<0.05 for both). The result of meta-analysis further demonstrated that the A allele of -308A was significantly correlated with DLBCL risk under the allelic model (OR=1.35, 95% CI=1.27-1.44) without heterogeneity by fixed-effects model analysis (Q=17.30, P=0.139). Moreover, sensitivity analysis supported the robustness of this meta-analysis.
  
  
  CONCLUSIONS
  This study suggested that -308A polymorphism may be associated with the susceptibility of DLBCL in a Chinese population. The further meta-analysis provides additional evidence supporting the above result that the risk allele of the -308A polymorphism may increase DLBCL risk.
authors.affiliation: Department of Hematology, First Affiliated Hospital of Xinxiang Medical University 88 Jiankang Road, Weihui 453100, Henan Province, China.
authors.forename: Cui
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Hematology, First Affiliated Hospital of Xinxiang Medical University 88 Jiankang Road, Weihui 453100, Henan Province, China.
authors.forename: Wanling
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Hematology, First Affiliated Hospital of Xinxiang Medical University 88 Jiankang Road, Weihui 453100, Henan Province, China.
authors.forename: Youmei
authors.initials: Y
authors.lastname: Zi
authors.affiliation: Department of Hematology, First Affiliated Hospital of Xinxiang Medical University 88 Jiankang Road, Weihui 453100, Henan Province, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Hematology, First Affiliated Hospital of Xinxiang Medical University 88 Jiankang Road, Weihui 453100, Henan Province, China.
authors.forename: Xiaoxue
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of Hematology, First Affiliated Hospital of Xinxiang Medical University 88 Jiankang Road, Weihui 453100, Henan Province, China.
authors.forename: Jingdong
authors.initials: J
authors.lastname: Li
authors.affiliation: Medical Center, Vanderbilt University School of Medicine Nashville, TN 37212, USA.
authors.forename: Honggang
authors.initials: H
authors.lastname: Ren
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha
keywords: TNF-α; diffuse large B-cell lymphoma; polymorphism