title: Childhood stunting and the metabolic syndrome components in young adults from a Brazilian birth cohort study.
abstract: The aim of this study was to investigate the association between stunting in the second year of life and metabolic syndrome components in early adulthood among subjects who have been prospectively followed-up since birth, in a city in Southern Brazil.
  
  
  
  In 1984, we attempted to follow-up the entire cohort; the subjects were examined and their mothers interviewed. Stunting was defined by a length-for-age Z-score 2 s.d. or more below the mean, in accordance with the World Health Organization reference. Between 2004 and 2005, we again tried to follow the entire cohort; during this period the subjects were evaluated for the following metabolic syndrome components: high-density lipoprotein (HDL) cholesterol, triglycerides, random blood glucose, waist circumference and systolic and diastolic blood pressure. Family income at the time of the baby's birth, asset index, mother's education, mother's smoking during pregnancy and duration of breastfeeding were considered possible confounders. Linear regression was used in the unadjusted and adjusted analyses.
  
  
  
  Among men, stunting was inversely associated with triglycerides (β=-11.90, confidence interval (CI)=-22.33 to -1.48) and waist circumference (β=-4.29, CI=-5.62 to -2.97), whereas for women stunting was negatively related to HDL-cholesterol (β=-4.50, CI=-6.47 to -2.52), triglycerides (β=-9.61, CI=-17.66 to -1.56) and waist circumference (β=-1.14, CI=-4.22 to -1.02). However, after controlling for confounding variables, these associations vanished.
  
  
  
  The findings suggest that stunting in childhood is not associated with metabolic syndrome components in young adults.
authors.affiliation: Departament of Nutrition, Vale of Itajaí University, Itajaí, Santa Catarina, Brazil.|Epidemiological Research Center, Epidemiology Postgraduate Program, Federal University of Pelotas, Rio Grande do Sul, Brazil.
authors.forename: L P
authors.initials: LP
authors.lastname: Grillo
authors.affiliation: Epidemiological Research Center, Epidemiology Postgraduate Program, Federal University of Pelotas, Rio Grande do Sul, Brazil.|Departament of Nutrition, Federal University of Pelotas, Rio Grande do Sul, Brazil.
authors.forename: D P
authors.initials: DP
authors.lastname: Gigante
authors.affiliation: Epidemiological Research Center, Epidemiology Postgraduate Program, Federal University of Pelotas, Rio Grande do Sul, Brazil.
authors.forename: B L
authors.initials: BL
authors.lastname: Horta
authors.affiliation: Epidemiological Research Center, Epidemiology Postgraduate Program, Federal University of Pelotas, Rio Grande do Sul, Brazil.
authors.forename: F C F
authors.initials: FC
authors.lastname: de Barros
mesh_terms: D001794:Blood Pressure; D001938:Brazil; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D006801:Humans; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides