title: [Small cell neuroendocrine carcinoma of the upper urinary tract: A case report].
abstract: Small cell neuroendocrine carcinoma of the upper urinary tract is extremely rare. To our knowledge, only 25 cases have been reported in the literature. The current study reports the case of an 80-year-old patient who suffered from macroscopic haematuria. A first screening by thoracic-abdominal-pelvic CT scan showed a mass located in the patient's left ureter and a left nephro-ureterectomy was consequently performed. The pathological examination of the resected specimen allowed the diagnosis of a small cell neuroendocrine carcinoma of the left ureter. After four months of follow-up, a PET-CT detected an isolated local recurrence on the left common iliac lymphadenopathy. After seven cycles of chemotherapy (carboplatin-etoposide), we observed a partial response followed by a new progression. It was then decided to perform an image-guided radiotherapy at a dose of 46.8 Gy, at 1.8 Gy per fraction, during 37 days to the left common iliac lymphadenopathy. After 16 months of follow-up, a complete metabolic remission was achieved. Indeed, this observation, followed by a short literature review, demonstrates the interest of radiotherapy for the treatment of a rare cancer: the small cell neuroendocrine carcinoma of the upper urinary tract.
authors.affiliation: Service de radiothérapie oncologique, centre hospitalier intercommunal Compiègne-Noyon, 8, rue Henri-Adnot, 60200 Compiègne, France; Service d'oncologie-radiothérapie, CHU d'Amiens, avenue René-Laënnec, 80480 Salouël, France. Electronic address: a.beddok@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Beddok
authors.affiliation: Service d'oncologie-hématologie, centre hospitalier intercommunal Compiègne-Noyon, 8, rue Henri-Adnot, 60200 Compiègne, France.
authors.forename: J
authors.initials: J
authors.lastname: Vanbocksteal
authors.affiliation: Service de radiothérapie oncologique, centre hospitalier intercommunal Compiègne-Noyon, 8, rue Henri-Adnot, 60200 Compiègne, France.
authors.forename: A
authors.initials: A
authors.lastname: Rakotonavalona
authors.affiliation: Service d'oncologie-hématologie, centre hospitalier intercommunal Compiègne-Noyon, 8, rue Henri-Adnot, 60200 Compiègne, France.
authors.forename: É-C
authors.initials: ÉC
authors.lastname: Ngatchou Taenga
authors.affiliation: Service de radiothérapie oncologique, centre hospitalier intercommunal Compiègne-Noyon, 8, rue Henri-Adnot, 60200 Compiègne, France.
authors.forename: M
authors.initials: M
authors.lastname: Faraldi
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000628:therapy; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D018714:Radiotherapy, Adjuvant; D012074:Remission Induction; D014516:Ureteral Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D005047:Etoposide; D016190:Carboplatin
keywords: Carcinome à petites cellules; Neuroendocrine; Small cell carcinoma; Tumeur des voies urinaires excrétrices supérieures; Upper urinary tract tumour