title: Clinical and economic burden of idiopathic pulmonary fibrosis: a retrospective cohort study.
abstract: BACKGROUND
  Idiopathic pulmonary fibrosis (IPF) is a devastating condition with a variable course. Not uncommonly, IPF patients are hospitalized for respiratory-related causes, including disease worsening. This study aimed to characterize the prevalence, and economic and health care burden of IPF.
  
  
  METHODS
  Retrospective insurance claims data collected yearly between January 1, 2009 and December 31, 2011, were used to determine prevalence and calculate all-cause and respiratory-related resource utilization and costs. Patients had at least one inpatient claim or two outpatient claims for IPF (ICD-9-CM code 516.3). Results for health care burden are reported for the 2011 cohort (similar findings in 2009-2010). Costs are reported in 2011 US dollars ($).
  
  
  RESULTS
  Patients with IPF had a mean age of 69.8-71.3 years. Overall prevalence for IPF was 28.8, 28.1 and 19.8 per 100,000 insured persons in 2009, 2010 and 2011. In each year, prevalence increased with age. In 2011, 37.7% of patients were hospitalized at least once for any cause; 19.5% for respiratory-related reasons. Also in 2011, the mean number of all-cause outpatient visits and respiratory-related office visits was 18.5 and 5.7 per patient, respectively. All-cause health care costs in 2011 were $59,379 per patient; 36.6% of costs ($21,732) were respiratory related.
  
  
  CONCLUSIONS
  The prevalence of IPF in this claims database increased with age, with a notable increase in those over 65 years. IPF is associated with a large economic and health care burden. Additional research is needed to determine how such burden might be reduced.
authors.affiliation: Genentech Inc., DNA Way, South San Francisco, CA, 94080, USA. raimundo.karina@gene.com.
authors.forename: Karina
authors.initials: K
authors.lastname: Raimundo
authors.affiliation: PHAR, LLC, Beverly Hills, CA, USA. echang@pharllc.com.
authors.forename: Eunice
authors.initials: E
authors.lastname: Chang
authors.affiliation: PHAR, LLC, Beverly Hills, CA, USA. mbroder@pharllc.com.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Broder
authors.affiliation: Genentech Inc., DNA Way, South San Francisco, CA, 94080, USA. alexander.kimberly@gene.com.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Alexander
authors.affiliation: Genentech Inc., DNA Way, South San Francisco, CA, 94080, USA. jamesz@gene.com.
authors.forename: James
authors.initials: J
authors.lastname: Zazzali
authors.affiliation: National Jewish Health, Denver, CO, USA. SwigrisJ@njhealth.org.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Swigris
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care / Q000191:economics / Q000706:statistics & numerical data*; D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D017048:Health Care Costs / Q000706:statistics & numerical data*; D006760:Hospitalization / Q000191:economics / Q000706:statistics & numerical data*; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000191:economics / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology