title: Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells.
abstract: DNA mismatch repair (MMR) protects genome integrity by correcting DNA replication-associated mispairs, modulating DNA damage-induced cell cycle checkpoints and regulating homeologous recombination. Loss of MMR function leads to cancer development. This review describes progress in understanding how MMR is carried out in the context of chromatin and how chromatin organization/compaction, epigenetic mechanisms and posttranslational modifications of MMR proteins influence and regulate MMR in eukaryotic cells.
authors.affiliation: Department of Medical Genetics, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern CA Keck School of Medicine, Los Angeles, CA 90033, USA.
authors.forename: Janice
authors.initials: J
authors.lastname: Ortega
authors.affiliation: Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern CA Keck School of Medicine, Los Angeles, CA 90033, USA.
authors.forename: Liya
authors.initials: L
authors.lastname: Gu
authors.affiliation: Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern CA Keck School of Medicine, Los Angeles, CA 90033, USA; Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing 100084, China. Electronic address: guominli@usc.edu.
authors.forename: Guo-Min
authors.initials: GM
authors.lastname: Li
mesh_terms: D000818:Animals; D042002:Chromatin Assembly and Disassembly; D053843:DNA Mismatch Repair; D005057:Eukaryotic Cells / Q000378:metabolism*; D042421:Histone Code; D006801:Humans; D008954:Models, Biological; D011499:Protein Processing, Post-Translational
keywords: Deacetylase; H3K36me3; Histone methylation; MSH2; PCNA; Phosphorylation; Ubiquitination