title: A reduced-order modeling for efficient design study of artificial valve in enlarged ventricular outflow tracts.
abstract: A computational approach is proposed for efficient design study of a reducer stent to be percutaneously implanted in enlarged right ventricular outflow tracts (RVOT). The need for such a device is driven by the absence of bovine or artificial valves which could be implanted in these RVOT to replace the absent or incompetent native valve, as is often the case over time after Tetralogy of Fallot repair. Hemodynamics are simulated in the stented RVOT via a reduce order model based on proper orthogonal decomposition, while the artificial valve is modeled as a thin resistive surface. The reduced order model is obtained from the numerical solution on a reference device configuration, then varying the geometrical parameters (diameter) for design purposes. To validate the approach, forces exerted on the valve and on the reducer are monitored, varying with geometrical parameters, and compared with the results of full CFD simulations. Such an approach could also be useful for uncertainty quantification.
authors.affiliation: a Weierstrass Institute for Applied Analysis and Stochastics (WIAS) , Berlin , Germany .
authors.forename: A
authors.initials: A
authors.lastname: Caiazzo
authors.affiliation: b Institut de Mécanique des Fluides de Toulouse , Toulouse , France .
authors.forename: R
authors.initials: R
authors.lastname: Guibert
authors.affiliation: c INRIA Paris-Rocquencourt and Sorbonne Universités, UPMC Univ Paris 6 , Paris , France .
authors.forename: I E
authors.initials: IE
authors.lastname: Vignon-Clementel
mesh_terms: D000465:Algorithms; D000818:Animals; D002417:Cattle; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006352:Heart Ventricles / Q000601:surgery*; D006439:Hemodynamics; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D015203:Reproducibility of Results
keywords: Device design; blood flow CFD; finite element method; percutaneous pulmonary valve replacement; proper orthogonal decomposition (POD); repaired Tetralogy of Fallot