title: O-Acyl oximes: versatile building blocks for N-heterocycle formation in recent transition metal catalysis.
abstract: O-Acyl oximes are versatile building blocks being widely applied in organic synthesis, especially for N-heterocycle construction under transition metal catalysis. In the last decade, aza-Heck cyclization using oximes has been progressing in the preparation of functionalized pyrrolines, and instead of Pd catalysis, copper-based catalytic systems were found to work well in some cases. O-Acyl oximes as oxidizing directing groups have attracted intensive attention in transition metal-mediated C-H activation reactions, which avoid the use of external oxidants to feature advantages including mild reaction conditions, higher levels of reactivities, chemo-selectivities, etc. Moreover, catalytic α C(sp(3))-H functionalization of O-acyl oximes and subsequent annulations provide a lot of opportunities for novel N-heterocycle synthesis. These transformations feature certain advantages: diversified and poly-functionalized products, mild and easy handling conditions, oximes serving as an internal oxidant to avoid the use of external oxidants, and so forth.
authors.affiliation: Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China. hwhuang@xtu.edu.cn gjdeng@xtu.edu.cn.
authors.forename: Huawen
authors.initials: H
authors.lastname: Huang
authors.affiliation: Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China. hwhuang@xtu.edu.cn gjdeng@xtu.edu.cn.
authors.forename: Jinhui
authors.initials: J
authors.lastname: Cai
authors.affiliation: Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China. hwhuang@xtu.edu.cn gjdeng@xtu.edu.cn.
authors.forename: Guo-Jun
authors.initials: GJ
authors.lastname: Deng