title: Differentiation of human innate lymphoid cells (ILCs).
abstract: During the last years, a high complexity in innate lymphoid lineages now collectively referred to as innate lymphoid cells (ILCs) has been revealed. ILCs can be grouped according to their effector functions and transcriptional requirements into three main groups, termed group 1, 2 and 3 ILCs. The differentiation of ILC lineages from hematopoietic precursors and the molecular switches guiding their developmental fate have started to be characterized both in mice and humans. In this review, we discuss the origin, differentiation stages and plasticity of human ILC subsets as well as the signals that drive ILC lineage commitment and acquisition of their unique effector programs.
authors.affiliation: Innate Immunity, Deutsches Rheuma Forschungszentrum (DRFZ) Berlin, Leibniz-Gemeinschaft, Berlin, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Juelke
authors.affiliation: Innate Immunity, Deutsches Rheuma Forschungszentrum (DRFZ) Berlin, Leibniz-Gemeinschaft, Berlin, Germany. Electronic address: romagnani@drfz.de.
authors.forename: Chiara
authors.initials: C
authors.lastname: Romagnani
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D002454:Cell Differentiation; D019070:Cell Lineage / Q000276:immunology*; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D016130:Immunophenotyping; D007372:Interferons / Q000235:genetics / Q000276:immunology; D007378:Interleukins / Q000235:genetics / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D051379:Mice; D009928:Organ Specificity; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology
chemical_list: D015703:Antigens, CD; D007378:Interleukins; D014157:Transcription Factors; D007372:Interferons