title: Molecularly Imprinted Polymers: Novel Discovery for Drug Delivery.
abstract: BACKGROUND
  Molecularly imprinted polymers (MIP) are novel carriers synthesized by imprinting of a template over a polymer. This paper presents the recent application of MIP for diagnostic and therapeutic drug delivery.
  
  
  BACKGROUND
  MIP owing to their 3D polymeric structures and due to bond formation with the template serves as a reservoir of active causing stimuli sensitive, enantioselective, targetted and/or controlled release. The review elaborates about key factors for optimization of MIP, controlled release by MIP for various administration routes various forms like patches, contact lenses, nanowires along with illustrations. To overcome the limitation of organic solvent usage causing increased cost, water compatible MIP and use of supercritical fluid technology for molecular imprinting were developed. Novel methods for developing water compatible MIP like pickering emulsion polymerization, co-precipitation method, cyclodextrin imprinting, surface grafting, controlled/living radical chain polymerization methods are described with illustration in this review. Various protein imprinting methods like bulk, epitope and surface imprinting are described along with illustrations. Further, application of MIP in microdevices as biomimetic sensing element for personalized therapy is elaborated.
  
  
  CONCLUSIONS
  Although development and application of MIP in drug delivery is still at its infancy, constant efforts of researchers will lead to a novel intelligent drug delivery with commercial value. Efforts should be directed in developing solid oral dosage forms consisting of MIP for therapeutic protein and peptide delivery and targeted release of potent drugs addressing life threatening disease like cancer. Amalgamation of bio-engineering and pharmaceutical techniques can make these future prospects into reality.
authors.affiliation: Bharati Vidyapeeth&#39;s College of Pharmacy, Belapur, C.B.D. 400614, India. dhanashri31@gmail.com.
authors.forename: Surve
authors.initials: S
authors.lastname: Dhanashree
authors.forename: Mohite
authors.initials: M
authors.lastname: Priyanka
authors.forename: Karpe
authors.initials: K
authors.lastname: Manisha
authors.forename: Kadam
authors.initials: K
authors.lastname: Vilasrao
mesh_terms: D025924:Chromatography, Supercritical Fluid; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D008968:Molecular Conformation; D054802:Molecular Imprinting / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011108:Polymers; D012997:Solvents; D014867:Water