title: Lysophospholipids and their G protein-coupled receptors in atherosclerosis.
abstract: Lysophospholipids (LPLs) are bioactive lipid-derived signaling molecules generated by the enzymatic and chemical processes of regiospecific phospholipases on substrates such as membrane phospholipids (PLs) and sphingolipids (SLs). They play a major role as extracellular mediators by activating G-protein coupled receptors (GPCRs) and stimulating diverse cellular responses from their signaling pathways. LPLs are involved in various pathologies of the vasculature system including coronary heart disease and hypertension. Many studies suggest the importance of LPLs in their association with the development of atherosclerosis, a chronic and severe vascular disease. This paper focuses on the pathophysiological effects of different lysophospholipids on atherosclerosis, which may promote the pathogenesis of myocardial infarction and strokes. Their atherogenic biological activities take place in vascular endothelial cells, vascular smooth muscle cells, fibroblasts, monocytes and macrophages, dendritic cells, T-lymphocytes, platelets, etc.
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province 430060, China.
authors.forename: Ya-Feng
authors.initials: YF
authors.lastname: Li
authors.affiliation: Department of Nephrology and Hemodialysis Center, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, China, rongshanli13@163.com.
authors.forename: Rong-Shan
authors.initials: RS
authors.lastname: Li
authors.affiliation: Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
authors.forename: Sonia B
authors.initials: SB
authors.lastname: Samuel
authors.affiliation: Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
authors.forename: Ramon
authors.initials: R
authors.lastname: Cueto
authors.affiliation: Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Li
authors.affiliation: Department of Lung Cancer, Affiliated Hospital of Academy of Military Medical Sciences(307 Hospital, PLA), No.8 DongDa Road, FengTai Area, Beijing, P. R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, Cardiovascular Research Center.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Yang
mesh_terms: D050197:Atherosclerosis / Q000503:physiopathology*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008246:Lysophospholipids / Q000096:biosynthesis / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000502:physiology*
chemical_list: D008246:Lysophospholipids; D043562:Receptors, G-Protein-Coupled