title: New sesquiterpenes from the rhizomes of homalomena occulta.
abstract: Six new sesquiterpenes (1-6), along with eight known ones (7-14) were isolated from the rhizomes of Homalomena occulta. Structure elucidation of the new compounds was achieved through 1D NMR, 2D NMR spectroscopic techniques and HRESIMS, while the absolute configurations of compounds 1, 2 and 5 were confirmed by X-ray crystallographic analysis. All of the isolates were evaluated for their activity against LPS-induced production of nitrogen oxide (NO) in macrophage cells, and compounds 1 and 5 showed inhibitory effect on NO production with the IC50 values of 21.2 and 15.4 μM, respectively.
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Guanai Road 346, Yantai 264003, China. Electronic address: zhaofeng2015@163.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Yantai Stomatological Hospital, Yantai 264001, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Sun
authors.affiliation: Yantai Stomatological Hospital, Yantai 264001, China.
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Guanai Road 346, Yantai 264003, China.
authors.forename: Yuan-Fang
authors.initials: YF
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Guanai Road 346, Yantai 264003, China.
authors.forename: Ju-Feng
authors.initials: JF
authors.lastname: Sun
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Guanai Road 346, Yantai 264003, China.
authors.forename: Gui-Ge
authors.initials: GG
authors.lastname: Hou
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Guanai Road 346, Yantai 264003, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cong
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Guanai Road 346, Yantai 264003, China.
authors.forename: Hong-Juan
authors.initials: HJ
authors.lastname: Li
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Guanai Road 346, Yantai 264003, China.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Zhang
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Guanai Road 346, Yantai 264003, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ren
authors.affiliation: The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Guanai Road 346, Yantai 264003, China. Electronic address: chunhuawang77@gmail.com.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Wang
mesh_terms: D000818:Animals; D029064:Araceae / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D010936:Plant Extracts / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D010936:Plant Extracts; D012717:Sesquiterpenes; D009569:Nitric Oxide
keywords: Crystallographic analysis; Homalomena occulta; NO production inhibition; Sesquiterpene