title: Convulsions following rapid ceftazidime administration for preinduction antibiotic prophylaxis during neurosurgical procedure.
abstract: Ceftazidime is a widely used antibiotic with broad spectrum activity against Gram-positive and Gram-negative microbes and is used prophylactically in neurosurgical patients prior to surgery. Neurotoxicity is a recognized complication of ceftazidime use but is reported predominantly after repeated administration in patients with impaired renal status. We encountered a patient with an intracranial tumor who developed generalized convulsions following a single dose of ceftazidime, which was infused rapidly and attempt to provide an explanation of this uncommon occurrence.
authors.affiliation: Department of Anaesthesiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: Rudrashish
authors.initials: R
authors.lastname: Haldar
authors.affiliation: Department of Anaesthesiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Kaushal
authors.affiliation: Department of Anaesthesiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: Devendra
authors.initials: D
authors.lastname: Gupta
authors.affiliation: Department of Anaesthesiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: Shashi
authors.initials: S
authors.lastname: Srivastava
authors.affiliation: Department of Anaesthesiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: Prabhat K
authors.initials: PK
authors.lastname: Singh
authors.affiliation: Department of Internal Medicine, Motilal Nehru Medical College, Allahabad, Uttar Pradesh, India.
authors.forename: Paurush
authors.initials: P
authors.lastname: Ambesh
keywords: Ceftazidime; convulsions; neurosurgery; neurotoxicity