title: Antimüllerian hormone and pregnancy loss from the Effects of Aspirin in Gestation and Reproduction trial.
abstract: OBJECTIVE
  To evaluate if antimüllerian hormone (AMH) is associated with pregnancy loss.
  
  
  METHODS
  Prospective cohort study within a block-randomized, double-blind, placebo-controlled trial of low-dose aspirin.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  Women (n = 1,228) were of ages 18-40 years with a history of one to two pregnancy losses and were actively attempting pregnancy without fertility treatment.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  Pregnancy loss.
  
  
  RESULTS
  Relative risks (and 95% confidence interval [CIs]) of human chorionic gonadotropin (hCG)-detected and clinical pregnancy loss were assessed with the use of log binomial models with robust variance and inverse probability weights adjusted for age, race, body mass index, income, trial treatment assignment, parity, number of previous losses, and time since most recent loss. AMH levels were defined as: low (<1.00 ng/mL; n = 124), normal (referent; 1.00-3.5 ng/mL; n = 595), and high (>3.5 ng/mL; n = 483). Of the 1,202 women with baseline AMH data, 19 (17.3%) with low AMH experienced a clinical loss, compared with 61 (11.4%) with normal AMH and 50 (11.8%) with high AMH levels. Low or high AMH levels, compared with normal AMH, were not associated with clinical loss. Results for hCG-detected pregnancy loss mirrored those of clinical loss.
  
  
  CONCLUSIONS
  AMH values were not associated with hCG-detected or clinical pregnancy loss in unassisted conceptions in women with a history of one to two previous losses. Our data do not support routine AMH testing for prediction of pregnancy loss.
  
  
  BACKGROUND
  NCT00467363.
authors.affiliation: Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland; Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
authors.forename: Shvetha M
authors.initials: SM
authors.lastname: Zarek
authors.affiliation: Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
authors.forename: Emily M
authors.initials: EM
authors.lastname: Mitchell
authors.affiliation: Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
authors.forename: Lindsey A
authors.initials: LA
authors.lastname: Sjaarda
authors.affiliation: Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
authors.forename: Sunni L
authors.initials: SL
authors.lastname: Mumford
authors.affiliation: Department of Obstetrics and Gynecology, University of Utah and Intermountain Healthcare, Salt Lake City, Utah.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Silver
authors.affiliation: Department of Obstetrics and Gynecology, University of Utah and Intermountain Healthcare, Salt Lake City, Utah.
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Stanford
authors.affiliation: Department of Statistics, University of Haifa, Haifa, Israel.
authors.forename: Noya
authors.initials: N
authors.lastname: Galai
authors.affiliation: Department of Statistics, University of Haifa, Haifa, Israel.
authors.forename: Karen C
authors.initials: KC
authors.lastname: Schliep
authors.affiliation: Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
authors.forename: Rose G
authors.initials: RG
authors.lastname: Radin
authors.affiliation: Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland; Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
authors.forename: Torie C
authors.initials: TC
authors.lastname: Plowden
authors.affiliation: Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
authors.forename: Alan H
authors.initials: AH
authors.lastname: DeCherney
authors.affiliation: Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland. Electronic address: schistee@mail.nih.gov.
authors.forename: Enrique F
authors.initials: EF
authors.lastname: Schisterman
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D001241:Aspirin / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate / Q000639:trends*; D011446:Prospective Studies; D012098:Reproduction / Q000187:drug effects / Q000502:physiology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone; D001241:Aspirin
keywords: Antimüllerian hormone; aneuploidy; miscarriage; pregnancy loss; spontaneous abortion