title: Tumour necrosis factor alpha, ınterleukin 10 and ınterleukin 6 gene polymorphisms of ıschemic stroke patients ın south Marmara region of Turkey.
abstract: BACKGROUND
  Stroke is an important cause of adult mortality and morbidity; however its pathogenesis is still unknown. Several studies have examined to determine the role of genetic polymorphism of proinflammatory cytokines in the occurence of stroke. The objective of this study was to evaluate the relationship between three polymorphisms; including tumour necrosis alpha (TNFα)-238 GA, interleukin( IL-10)-1028 GA (rs1800896), IL-6-(rs1800795) and ischemic stroke in a Turkish population.
  
  
  METHODS
  Forty two stroke patients and 48 healhty controls were genotyped using PCR analysis for TNFα-238 G/A, IL-10-1028 GA and IL-6-rs1800795 AG polymorphisms.
  
  
  RESULTS
  The frequency of the CC and CG, GG genotype of IL-6 gene (rs1800795) were statiscially significiantly higher in IS patients than controls (for C/C genotype, P=0.03, OR=4.3; 95% CI: 1.13 to 16.29 and for C/G genotype, P=0.04, OR=3.6; 95% CI: 1.03 to 12.95, for G/G genotype, P=0.02, OR=0.25; 95% CI: 0.07-0.85 respectively).
  
  
  CONCLUSIONS
  Il-6 CC genotyped was found strongly associated with ischemic stroke than other two polymorpisms TNF-α and IL-10 in our population.
authors.affiliation: Department of Neurology, Canakkale 18 Mart University Medical Faculty Canakkale, Turkey.
authors.forename: Adile
authors.initials: A
authors.lastname: Ozkan
authors.affiliation: Department of Genetics, Canakkale 18 Mart University Medical Faculty Canakkale, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Sılan
authors.affiliation: Department of Genetics, Canakkale 18 Mart University Medical Faculty Canakkale, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Uludağ
authors.affiliation: Department of Neurology, Duzce University Medical Faculty Duzce, Turkey.
authors.forename: Yıldız
authors.initials: Y
authors.lastname: Degirmenci
authors.affiliation: Department of Neurology, Canakkale 18 Mart University Medical Faculty Canakkale, Turkey.
authors.forename: Handan Isin
authors.initials: HI
authors.lastname: Ozisik Karaman
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020521:Stroke / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D014421:Turkey
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10
keywords: Il-10; Il-6; Stroke; TNF-α; polymorhisms