title: Child Intelligence and Reductions in Water Arsenic and Manganese: A Two-Year Follow-up Study in Bangladesh.
abstract: Arsenic (As) exposure from drinking water is associated with modest intellectual deficits in childhood. It is not known whether reducing exposure is associated with improved intelligence.
  
  
  
  We aimed to determine whether reducing As exposure is associated with improved child intellectual outcomes.
  
  
  
  Three hundred three 10-year-old children drinking from household wells with a wide range of As concentrations were enrolled at baseline. In the subsequent year, deep community wells, low in As, were installed in villages of children whose original wells had high water As (WAs ≥ 50 μg/L). For 296 children, intelligence was assessed by WISC-IV (Wechsler Intelligence Scale for Children, 4th ed.), with a version modified for the study population, at baseline and approximately 2 years later; analyses considered standardized scores for both Full Scale IQ and Verbal Comprehension, Perceptual Reasoning, Working Memory, and Processing Speed Indices. Creatinine-adjusted urinary arsenic (UAs/Cr), blood As (BAs), and blood manganese (BMn) were assessed at both times.
  
  
  
  UAs/Cr concentrations declined significantly by follow-up for both the high (≥ 50 μg/L) and low (< 50 μg/L) WAs subgroups. At baseline, adjusting for maternal age and intelligence, plasma ferritin, head circumference, home environment quality, school grade, and BMn, UAs/Cr was significantly negatively associated with Full Scale IQ, and with all Index scores (except Processing Speed). After adjustment for baseline Working Memory scores and school grade, each 100-μg/g reduction in UAs/Cr from baseline to follow-up was associated with a 0.91 point increase in Working Memory (95% CI: 0.14, 1.67). The change in UAs/Cr across follow-up was not significantly associated with changes in Full Scale IQ or Index scores.
  
  
  
  Installation of deep, low-As community wells lowered UAs, BAs, and BMn. A greater decrease in UAs/Cr was associated with greater improvements in Working Memory scores, but not with a greater improvement in Full Scale IQ.
  
  
  
  Wasserman GA, Liu X, Parvez F, Factor-Litvak P, Kline J, Siddique AB, Shahriar H, Uddin MN, van Geen A, Mey JL, Balac O, Graziano JH. 2016. Child intelligence and reductions in water arsenic and manganese: a two-year follow-up study in Bangladesh. Environ Health Perspect 124:1114-1120; http://dx.doi.org/10.1289/ehp.1509974.
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
authors.forename: Gail A
authors.initials: GA
authors.lastname: Wasserman
authors.forename: Xinhua
authors.initials: X
authors.lastname: Liu
authors.forename: Faruque
authors.initials: F
authors.lastname: Parvez
authors.forename: Pam
authors.initials: P
authors.lastname: Factor-Litvak
authors.forename: Jennie
authors.initials: J
authors.lastname: Kline
authors.forename: Abu B
authors.initials: AB
authors.lastname: Siddique
authors.forename: Hasan
authors.initials: H
authors.lastname: Shahriar
authors.forename: Mohammed Nasir
authors.initials: MN
authors.lastname: Uddin
authors.forename: Alexander
authors.initials: A
authors.lastname: van Geen
authors.forename: Jacob L
authors.initials: JL
authors.lastname: Mey
authors.forename: Olgica
authors.initials: O
authors.lastname: Balac
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Graziano
mesh_terms: D001151:Arsenic / Q000032:analysis*; D001459:Bangladesh / Q000453:epidemiology; D002648:Child; D002657:Child Development; D004781:Environmental Exposure / Q000517:prevention & control / Q000706:statistics & numerical data*; D006801:Humans; D007360:Intelligence / Q000187:drug effects*; D008345:Manganese / Q000032:analysis*; D014874:Water Pollutants, Chemical / Q000032:analysis*; D014877:Water Pollution, Chemical / Q000517:prevention & control; D060986:Water Wells
chemical_list: D014874:Water Pollutants, Chemical; D008345:Manganese; D001151:Arsenic