title: α-Glucosidase Inhibitory Prenylated Anthranols from Harungana madagascariensis.
abstract: Four new prenylated anthranols, harunganols C-F (1-4), along with kenganthranol A (5), harunganin (6), and ferruginin A (7), were identified from the leaves of Harungana madagascariensis. The structures of compounds 2, 5, and 7 were confirmed by single-crystal X-ray diffraction analysis. Compound 1 is a unique symmetrical anthranol dimer connected via a CH2 group. Compound 4 possesses a unique C-10 hemiketal group. All anthranols were evaluated for their α-glucosidase inhibitory activities. They displayed a higher potency compared to acarbose except for 3 and 4. In particular, harunganol C (1) showed an IC50 value of 1.2 μM.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.|Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos , CMUL Campus, Lagos 100254, Nigeria.
authors.forename: Oluwatosin O
authors.initials: OO
authors.lastname: Johnson
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
authors.forename: Jordan
authors.initials: J
authors.lastname: Gunn
authors.affiliation: Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago , Chicago, Illinois 60607, United States.
authors.forename: Bernard D
authors.initials: BD
authors.lastname: Santarsiero
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.|Department of Natural Medicinal Chemistry & State Key Laboratory of Natural Medicines, China Pharmaceutical University , Nanjing 210009, People's Republic of China.
authors.forename: Zhi-Qi
authors.initials: ZQ
authors.lastname: Yin
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos , CMUL Campus, Lagos 100254, Nigeria.
authors.forename: Gloria A
authors.initials: GA
authors.lastname: Ayoola
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos , CMUL Campus, Lagos 100254, Nigeria.
authors.forename: H A B
authors.initials: HA
authors.lastname: Coker
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
authors.forename: Chun-Tao
authors.initials: CT
authors.lastname: Che
mesh_terms: D000875:Anthralin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D028084:Clusiaceae / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009549:Nigeria; D018515:Plant Leaves / Q000737:chemistry; D000520:alpha-Glucosidases / Q000187:drug effects*
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D000520:alpha-Glucosidases; D000875:Anthralin