title: Association between hematologic parameters and in-hospital mortality in patients with infective endocarditis.
abstract: Early and accurate risk prediction is an important clinical demand in patients with infective endocarditis (IE). The platelet-to-lymphocyte ratio (PLR) is an independent predictor of worse prognosis in various cardiovascular diseases. The aim of this study was to determine the value of PLR in the prediction of in-hospital mortality among IE patients. We retrospectively analyzed the clinical, laboratory, and echocardiographic data of 59 adult patients with definite IE and in 40 adult controls. In-hospital mortality occurred in 16 (27%) patients. Vegetation size, levels of high-sensitive C-reactive protein and procalcitonin, neutrophil-to-lymphocyte ratio, and PLR were significantly higher in the in-hospital-mortality-positive group than in the in-hospital-mortality-negative group (p = 0.004, p = 0.009, p = 0.030, p = 0.001, and p = 0.008, respectively). Lymphocyte count was, however, significantly lower in the in-hospital-mortality-positive group (p = 0.004). In the receiver-operating characteristic analysis, PLRs over 191.01 predicted in-hospital mortality with 56.3% sensitivity and 81.4% specificity [area under the curve 0.725, 95% confidence interval (CI) 0.594-0.833; p = 0.0027]. In the multivariate analysis, PLR was found to be an independent predictor of in-hospital mortality in patients with IE (odds ratio 1.022, 95% CI 1.003-1.042; p = 0.021). In conclusion, higher PLR may predict in-hospital mortality in patients with IE.
authors.affiliation: Department of Cardiology, Adnan Menderes University School of Medicine, Aydin, Turkey. Electronic address: drczencir@hotmail.com.
authors.forename: Cemil
authors.initials: C
authors.lastname: Zencir
authors.affiliation: Department of Cardiology, Adnan Menderes University School of Medicine, Aydin, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Akpek
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Celal Bayar University School of Medicine, Manisa, Turkey.
authors.forename: Sebnem
authors.initials: S
authors.lastname: Senol
authors.affiliation: Department of Cardiology, Adnan Menderes University School of Medicine, Aydin, Turkey.
authors.forename: Mithat
authors.initials: M
authors.lastname: Selvi
authors.affiliation: Department of Cardiology, Adnan Menderes University School of Medicine, Aydin, Turkey.
authors.forename: Sevil
authors.initials: S
authors.lastname: Onay
authors.affiliation: Department of Cardiology, Adiyaman University School of Medicine, Adiyaman, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cetin
authors.affiliation: Department of Cardiology, Adnan Menderes University School of Medicine, Aydin, Turkey.
authors.forename: Cagdas
authors.initials: C
authors.lastname: Akgullu
authors.affiliation: Department of Family Medicine, Celal Bayar University School of Medicine, Manisa, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Elbi
authors.affiliation: Department of Cardiology, Adnan Menderes University School of Medicine, Aydin, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Gungor
mesh_terms: D001792:Blood Platelets; D004696:Endocarditis / Q000097:blood* / Q000401:mortality*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012372:ROC Curve; D012044:Regression Analysis
keywords: In-hospital mortality; Infective endocarditis; Platelet-to-lymphocyte ratio