title: Antisocial tendencies in alcohol-dependent men and their relation to harman, salsolinol and dopamine.
abstract: Plasma dopamine, β-carbolines (norharman, harman) and isoquinolines ((R)- and (S)-salsolinol) were examined for their relationship to antisocial tendencies in 138 drinking men with an alcohol dependence syndrome according to ICD-10 criteria. Antisociality was assessed according to the following criteria: delinquency, involvement in fist-fights and homelessness. The personality structure was documented by the Tridimensional Personality Questionnaire of Cloninger. An early age of onset of alcohol dependence and a high degree of 'novelty seeking' were associated with antisocial tendencies. Of the β-carbolines and isoquinolines, harman and (S)-salsolinol were significantly decreased among antisocial alcoholics. Norharman, (R)-salsolinol and dopamine were not associated with antisocial personality. The contribution of endogenous alkaloids to the biological characterization of antisocial tendencies in alcoholics is described.
authors.affiliation: Outpatient Unit for Dependencies, Freie Universität Berlin, GermanyInstitute of Neuropsychopharmacology, Freie Universität Berlin, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Podschus
authors.affiliation: Outpatient Unit for Dependencies, Freie Universität Berlin, GermanyInstitute of Neuropsychopharmacology, Freie Universität Berlin, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Dufeu
authors.affiliation: Outpatient Unit for Dependencies, Freie Universität Berlin, GermanyInstitute of Neuropsychopharmacology, Freie Universität Berlin, Germany.
authors.forename: L G
authors.initials: LG
authors.lastname: Schmidt
authors.affiliation: Outpatient Unit for Dependencies, Freie Universität Berlin, GermanyInstitute of Neuropsychopharmacology, Freie Universität Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Sallstrom-Baum
authors.affiliation: Outpatient Unit for Dependencies, Freie Universität Berlin, GermanyInstitute of Neuropsychopharmacology, Freie Universität Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Rommelspacher