title: Novel platinum-palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities.
abstract: Medicinal plants serve as rich sources of diverse bioactive phytochemicals that might even take part in bioreduction and stabilization of phytogenic nanoparticles with immense therapeutic properties. Herein, we report for the first time the rapid efficient synthesis of novel platinum-palladium bimetallic nanoparticles (Pt-PdNPs) along with individual platinum (PtNPs) and palladium (PdNPs) nanoparticles using a medicinal plant, Dioscorea bulbifera tuber extract (DBTE). High-resolution transmission electron microscopy revealed monodispersed PtNPs of size 2-5 nm, while PdNPs and Pt-PdNPs between 10 and 25 nm. Energy dispersive spectroscopy analysis confirmed 30.88% ± 1.73% elemental Pt and 68.96% ± 1.48% elemental Pd in the bimetallic nanoparticles. Fourier transform infrared spectra indicated strong peaks at 3,373 cm(-1), attributed to hydroxyl group of polyphenolic compounds in DBTE that might play a key role in bioreduction in addition to the sharp peaks at 2,937, 1,647, 1,518, and 1,024 cm(-1), associated with C-H stretching, N-H bending in primary amines, N-O stretching in nitro group, and C-C stretch, respectively. Anticancer activity against HeLa cells showed that Pt-PdNPs exhibited more pronounced cell death of 74.25% compared to individual PtNPs (12.6%) or PdNPs (33.15%). Further, Pt-PdNPs showed an enhanced scavenging activity against 2,2-diphenyl-1-picrylhydrazyl, superoxide, nitric oxide, and hydroxyl radicals.
authors.affiliation: Institute of Bioinformatics and Biotechnology, University of Pune, Pune, India.
authors.forename: Sougata
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Institute of Bioinformatics and Biotechnology, University of Pune, Pune, India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Nitnavare
authors.affiliation: Institute of Bioinformatics and Biotechnology, University of Pune, Pune, India.
authors.forename: Ankush
authors.initials: A
authors.lastname: Dewle
authors.affiliation: Institute of Bioinformatics and Biotechnology, University of Pune, Pune, India.
authors.forename: Geetanjali B
authors.initials: GB
authors.lastname: Tomar
authors.affiliation: Institute of Bioinformatics and Biotechnology, University of Pune, Pune, India.
authors.forename: Rohan
authors.initials: R
authors.lastname: Chippalkatti
authors.affiliation: Institute of Bioinformatics and Biotechnology, University of Pune, Pune, India.
authors.forename: Piyush
authors.initials: P
authors.lastname: More
authors.affiliation: Department of Applied Physics, Defense Institute of Advanced Technology, Pune, India.
authors.forename: Rohini
authors.initials: R
authors.lastname: Kitture
authors.affiliation: Department of Applied Physics, Defense Institute of Advanced Technology, Pune, India.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Kale
authors.affiliation: Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai, India.
authors.forename: Jayesh
authors.initials: J
authors.lastname: Bellare
authors.affiliation: Department of Microbiology, University of Pune, Pune, India.
authors.forename: Balu A
authors.initials: BA
authors.lastname: Chopade
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D027742:Dioscorea / Q000737:chemistry*; D005434:Flow Cytometry; D006367:HeLa Cells; D006801:Humans; D017665:Hydroxyl Radical / Q000737:chemistry; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D009569:Nitric Oxide / Q000737:chemistry; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010984:Platinum / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission; D013481:Superoxides / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D010936:Plant Extracts; D013481:Superoxides; D009569:Nitric Oxide; D017665:Hydroxyl Radical; D010984:Platinum; D010165:Palladium
keywords: Dioscorea bulbifera; anticancer; antioxidant; palladium nanoparticles; platinum nanoparticles; platinum-palladium bimetallic nanoparticles