title: PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome.
abstract: Hypertension is an important component of metabolic syndrome. Adulthood hypertension and metabolic syndrome can be programmed in response to nutritional insults in early life. Peroxisome proliferator-activated receptors (PPARs) serve as a nutrient-sensing signaling linking nutritional programming to hypertension and metabolic syndrome. All three members of PPARs, PPARα, PPARβ/δ, and PPARγ, are expressed in the kidney and involved in blood pressure control. This review provides an overview of potential clinical applications of targeting on the PPARs in the kidney to prevent programmed hypertension and metabolic syndrome, with an emphasis on the following areas: mechanistic insights to interpret programmed hypertension; the link between the PPARs, nutritional insults, and programmed hypertension and metabolic syndrome; the impact of PPAR signaling pathway in a maternal high-fructose model; and current experimental studies on early intervention by PPAR modulators to prevent programmed hypertension and metabolic syndrome. Animal studies employing a reprogramming strategy via targeting PPARs to prevent hypertension have demonstrated interesting results. It is critical that the observed effects on developmental reprogramming in animal models are replicated in human studies, to halt the globally-growing epidemic of metabolic syndrome-related diseases.
authors.affiliation: Departments of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. tainyl@cgmh.org.tw.|Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. tainyl@cgmh.org.tw.
authors.forename: You-Lin
authors.initials: YL
authors.lastname: Tain
authors.affiliation: Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. cnhsu@cgmh.org.tw.|School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. cnhsu@cgmh.org.tw.
authors.forename: Chien-Ning
authors.initials: CN
authors.lastname: Hsu
authors.affiliation: Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. jchan@cgmh.org.tw.
authors.forename: Julie Y H
authors.initials: JY
authors.lastname: Chan
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D004040:Dietary Carbohydrates / Q000009:adverse effects*; D005260:Female; D005632:Fructose / Q000009:adverse effects; D005786:Gene Expression Regulation; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D018811:Maternal Exposure; D024821:Metabolic Syndrome / Q000209:etiology / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control; D009752:Nutritional Status; D047492:Peroxisome Proliferator-Activated Receptors / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control; D020033:Protein Isoforms / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000959:Antihypertensive Agents; D004040:Dietary Carbohydrates; D047492:Peroxisome Proliferator-Activated Receptors; D020033:Protein Isoforms; D005632:Fructose
keywords: developmental programming; hypertension; kidney; metabolic syndrome; nutrient sensing; peroxisome proliferator-activated receptor