title: [Detection of complementary transcripts in intergenic region of the chicken α-globin gene domain].
abstract: Using strand-specific reverse transcription followed by Real Time PCR analysis we have characterized the transcription profile of the segment of chicken α-globin gene domain harboring embryonic gene π, adult gene αD and spacer region separating these genes. It has been demonstrated that in erythroid cells of adult lineage the spacer region is transcribed in both directions. These results suggest a possibility that switching of α-globin genes expression is controlled by RNA-interference mechanism.
authors.affiliation: Institute of Gene Biology, Russian Academy of Sciences, Moscow, 117334;|ioudinkova@inbox.ru.
authors.forename: E S
authors.initials: ES
authors.lastname: Ioudinkova
authors.affiliation: Biological Faculty, Moscow State University, Moscow, 119992 Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Nefedochkina
authors.affiliation: Institute of Gene Biology, Russian Academy of Sciences, Moscow, 117334;
authors.forename: O V
authors.initials: OV
authors.lastname: Iarovaia
authors.affiliation: Institute of Gene Biology, Russian Academy of Sciences, Moscow, 117334;|Biological Faculty, Moscow State University, Moscow, 119992 Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Razin
mesh_terms: D000818:Animals; D002645:Chickens; D021901:DNA, Intergenic; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D055542:alpha-Globins / Q000235:genetics* / Q000378:metabolism
chemical_list: D021901:DNA, Intergenic; D012333:RNA, Messenger; D055542:alpha-Globins
keywords: gene expression; regulation of transcription; α-globin gene domain