title: Synthesis, Magnetic Properties, Map Images, and Water Proton Relaxivities of D-Glucuronic Acid Coated Ln2O3 Nanoparticles (Ln = Ho and Er).
abstract: T2 MRI contrast agents cannot be synthesized by using molecules but nanoparticles because appreciable magnetic moments at room temperature are needed. Recently, some of lanthanide (Ln) oxide nanoparticles have shown decent magnetic moments at room temperature and even at ultrasmall particle diameters. In this study, we explored D-glucuronic acid coated Ln2O3 nanoparticles (Ln = Ho and Er) with ultrasmall particle diameters. They showed decent magnetic moments at room temperature and as a result, appreciable transverse water proton relaxivities (r2s) at 1.5 tesla MR field. Clear dose-dependent contrast enhancements in R2 map images were observed in both samples. These results showed that D-glucuronic acid coated Ln2O3 nanoparticles (Ln = Ho and Er) would be potential T2 MRI contrast agents at high MR fields.
authors.forename: Krishna
authors.initials: K
authors.lastname: Kattel
authors.forename: Cho Rong
authors.initials: CR
authors.lastname: Kim
authors.forename: Wenlong
authors.initials: W
authors.lastname: Xu
authors.forename: Tae Jeong
authors.initials: TJ
authors.lastname: Kim
authors.forename: Jang Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Chang
authors.forename: Gang Ho
authors.initials: GH
authors.lastname: Lee
mesh_terms: D003287:Contrast Media; D004871:Erbium / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry*; D006695:Holmium / Q000737:chemistry*; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D011522:Protons; D014867:Water
chemical_list: D003287:Contrast Media; D010087:Oxides; D011522:Protons; D014867:Water; C093389:erbium oxide; D004871:Erbium; D020723:Glucuronic Acid; D006695:Holmium