title: Meiotic DSB patterning: A multifaceted process.
abstract: Meiosis is a specialized two-step cell division responsible for genome haploidization and the generation of genetic diversity during gametogenesis. An integral and distinctive feature of the meiotic program is the evolutionarily conserved initiation of homologous recombination (HR) by the developmentally programmed induction of DNA double-strand breaks (DSBs). The inherently dangerous but essential act of DSB formation is subject to multiple forms of stringent and self-corrective regulation that collectively ensure fruitful and appropriate levels of genetic exchange without risk to cellular survival. Within this article we focus upon an emerging element of this control--spatial regulation--detailing recent advances made in understanding how DSBs are evenly distributed across the genome, and present a unified view of the underlying patterning mechanisms employed.
authors.affiliation: a Genome Damage and Stability Centre, School of Life Sciences, University of Sussex , Brighton , UK.
authors.forename: Tim J
authors.initials: TJ
authors.lastname: Cooper
authors.affiliation: b Centre de Recherche en Cancérologie de Marseille , Marseille , France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Garcia
authors.affiliation: a Genome Damage and Stability Centre, School of Life Sciences, University of Sussex , Brighton , UK.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Neale
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000502:physiology*; D059765:Homologous Recombination / Q000502:physiology; D006801:Humans; D008540:Meiosis / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D018797:Cell Cycle Proteins; D029701:Saccharomyces cerevisiae Proteins
keywords: ATM; DSB competition; DSB formation; DSB hotspots; DSB interference; Tel1; meiosis; recombination