title: The new face of non-small-cell lung cancer in men: Results of two French prospective epidemiological studies conducted 10 years apart.
abstract: OBJECTIVE
  To evaluate the impact of epidemiological changes observed in 10 years in men with NSCLC on 1-year mortality; to compare prognosis factors of 1-year mortality according to gender.
  
  
  METHODS
  The French College of General Hospital Respiratory Physicians conducted two prospective epidemiological multicentre studies at a 10-year interval (KBP-2000-CPHG and KBP-2010-CPHG). These studies included all adult patients with primary lung cancer histologically or cytologically diagnosed between 1(st) January and 31(st) December for the years 2000 and 2010, managed in the pneumology department of the participating hospitals. A standardised form was completed for each patient. A steering committee checked recruitment exhaustiveness. Vital status 1 year after diagnosis was collected.
  
  
  RESULTS
  In 2000 and 2010 respectively, 137 and 104 centres included 3921 and 4597 men and 748 and 1486 women with NSCLC. In 2010 compared to 2000, male patients were older but had better performance status (PS); they were less frequently ever-smokers and heavy smokers; their cancer (usually diagnosed at advanced stage) was more often adenocarcinoma (p<0.0001). In 10 years, 1-year mortality has significantly decreased in men (from 61.2% to 56.6%, p<0.0001) and in women (from 58.1% to 50.9%, p<0.0001), but remained higher in men than in women leading to increased difference between men and women. Decreased 1-year mortality remained statistically significant after adjustment on age, PS, smoking, and histology (men: OR=0.81, 95% CI=0.73-0.90, p<0.0001; women: 0.71, 0.57-0.88, p<0.002). Active smoking was not a prognosis factor in men (OR=1.04, CI=0.79-1.37, p=0.78); age (>75 years) had less impact on mortality in men than in women (men: OR=1.43, CI=1.22-1.67, p ≤ 0.0001; women: OR=2.32, CI=1.71-3.15; p<0.0001).
  
  
  CONCLUSIONS
  The improved 1-year survival in 2010 as compared with 2000 was independent of age, smoking, PS, and histology, suggesting that it reflected new treatment and strategy efficacy. One-year mortality remains higher in men than in women.
authors.affiliation: Pneumology Department, Emile Muller Hospital, 20 Avenue du Docteur René Laennec, 68070 Mulhouse, France. Electronic address: debieuvred@ch-mulhouse.fr.
authors.forename: Didier
authors.initials: D
authors.lastname: Debieuvre
authors.affiliation: Pneumology Department, Colmar Civil Hospitals, 39 Avenue de la Liberté, 68024 Colmar Cedex, France. Electronic address: jeanphilippe.oster@ch-colmar.fr.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Oster
authors.affiliation: Pneumology Department, Valence General Hospital, 179 Avenue du Maréchal Juin, 26953 Valence, France. Electronic address: rriou@ch-valence.fr.
authors.forename: Robert
authors.initials: R
authors.lastname: Riou
authors.affiliation: Pneumology Department, Departmental Hospital, Les Oudairies, 85925 La-Roche-sur-Yon, Cedex 9, France. Electronic address: jberruch@chd-vendee.fr.
authors.forename: Jacques
authors.initials: J
authors.lastname: Berruchon
authors.affiliation: Pneumology Department, Jacques Coeur Hospital, 145 Avenue François Mitterrand, CS30010, 18020 Bourges Cedex, France. Electronic address: antoine.levy@ch-bourges.fr.
authors.forename: Antoine
authors.initials: A
authors.lastname: Levy
authors.affiliation: Pneumology Department, Côte Basque Hospital, 13 Avenue de l'interne Jacques Loëb, BP 8, 64109 Bayonne Cedex, France. Electronic address: jpmathieu004@ch-cotebasque.fr.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Mathieu
authors.affiliation: Pneumology Department, Chauny Hospital, 94 Rue des Anciens Combattants dA.F.N. & T.O.M., 02303 Chauny, France. Electronic address: dr.dumont@ch-chauny.fr.
authors.forename: Patrick
authors.initials: P
authors.lastname: Dumont
authors.affiliation: Pneumology Department, Meulan-Les Mureaux Intercommunal Hospital, 1 Rue du Fort, 78250 Meulan-en-Yvelines, France. Electronic address: etiennelt@hotmail.com.
authors.forename: Etienne
authors.initials: E
authors.lastname: Leroy-Terquem
authors.affiliation: Pneumology Department, Avranches-Granville Hospital, 849 Rue des Menneries, BP 629, 50406 Granville Cedex, France. Electronic address: veronique.tizon@ch-avranches-granville.fr.
authors.forename: Véronique
authors.initials: V
authors.lastname: Tizon-Couetil
authors.affiliation: Pneumology and Sleep Disorders Department, Compiègne-Noyon, Intercommunal Hospital, 8 Avenue Henri Adnot, BP 50029, 60321 Compiègne Cedex, France. Electronic address: f.martin@ch-compiegnenoyon.fr.
authors.forename: Francis
authors.initials: F
authors.lastname: Martin
authors.affiliation: Pneumology Department, Hospital, 6-8 Rue Saint Fiacre, BP 218, 77104 Meaux Cedex, France. Electronic address: m-grivaux@ch-meaux.fr.
authors.forename: Michel
authors.initials: M
authors.lastname: Grivaux
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D011446:Prospective Studies; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology / Q000401:mortality
keywords: Adenocarcinoma; Carcinoma; Epidemiology; France; Gender; Hospitals; Male; Non-small-cell lung cancer