title: Chinese Pediatric Organ Donation With Scheduled Cardiac Arrest After Brain Death: A Novel China Classification Beyond Maastricht.
abstract: OBJECTIVE
  Organ donation with scheduled cardiac arrest after brain death (s-DBCD) is a special category in China. This study was to evaluate the procedure of pediatric s-DBCD, graft quality, and clinical outcomes of single kidney transplantation.
  
  
  METHODS
  We retrospectively analyzed the data of 8 Chinese pediatric donors.
  
  
  RESULTS
  The death causes of the donors (age 4-12 years) were cerebral hypoxia after cardiopulmonary resuscitation (n = 1), intracranial vascular malformation (n = 1), severe traumatic brain injury (n = 3), and brain malignancy (n = 3). The functional warm ischemia time of the grafts was 18 (13-26) minutes. Sixteen kidneys were recovered using liver-kidney en bloc procurement after in situ perfusion. All kidneys had a length >7 cm and were transplanted to 3 adolescent and 13 adult recipients. Two cases of delayed graft function occurred. The patients had a median serum creatinine level of 97 (55-123) μmol/L by the last visit. The median estimated glomerular filtration rate level was 85.4 (58-136) mL/min. Five episodes of biopsy-proven acute rejection occurred in 4 patients, which were reversed by methylprednisolone pulse therapy. Renal arterial stenosis was observed in 1 patient, which was cured by interventional balloon dilatation and stent implantation.
  
  
  CONCLUSIONS
  Pediatric s-DBCD is feasible with acceptable graft quality. Single kidney transplantation with pediatric graft size >7 cm has good clinical outcomes.
authors.affiliation: Organ Transplant Institute, Fuzhou General Hospital (Dongfang Hospital), Xiamen University, Fuzhou, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Organ Transplant Institute, Fuzhou General Hospital (Dongfang Hospital), Xiamen University, Fuzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Hepatobiliary Disease, Fuzhou General Hospital (Dongfang Hospital), Xiamen University, Fuzhou, China.
authors.forename: F
authors.initials: F
authors.lastname: Chen
authors.affiliation: Organ Transplant Institute, Fuzhou General Hospital (Dongfang Hospital), Xiamen University, Fuzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: Tao
authors.affiliation: Organ Transplant Institute, Fuzhou General Hospital (Dongfang Hospital), Xiamen University, Fuzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Cai
authors.affiliation: Organ Transplant Institute, Fuzhou General Hospital (Dongfang Hospital), Xiamen University, Fuzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Guo
authors.affiliation: Organ Transplant Institute, Fuzhou General Hospital (Dongfang Hospital), Xiamen University, Fuzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.affiliation: Organ Transplant Institute, Fuzhou General Hospital (Dongfang Hospital), Xiamen University, Fuzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Tan
authors.affiliation: Organ Transplant Institute, Fuzhou General Hospital (Dongfang Hospital), Xiamen University, Fuzhou, China. Electronic address: ysliang@medmail.com.cn.
authors.forename: S
authors.initials: S
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D001926:Brain Death; D002648:Child; D002681:China; D005260:Female; D005919:Glomerular Filtration Rate; D006084:Graft Rejection; D006085:Graft Survival; D006323:Heart Arrest; D006801:Humans; D007668:Kidney / Q000033:anatomy & histology; D016030:Kidney Transplantation; D008297:Male; D012189:Retrospective Studies; D014019:Tissue Donors