title: Enterococcus faecalis as multidrug resistance strains in clinical isolates in Imam Reza Hospital in Kermanshah, Iran.
abstract: The current study aimed to investigate the prevalence of vancomycin-resistant Enterococcus in E. faecalis and E. faecium and antimicrobial susceptibility patterns, then dominant genes responsible for vancomycin resistance were determined. For this propose, 180 clinical isolates of Enterococcus were subjected for identification and antibiotic susceptibility assay. Then, the gene responsible vancomycin resistant strains were determined. The results demonstrated the E. faecalis as a dominant Enterococcus. Resistance to erythromycin was dominant and multidrug resistance strains observed in E. faecalis. vanA was responsible for vancomycin resistance. In conclusion, a high rate of resistance to antibiotics in Enterococcus is clearly problematic, and a novel strategy is needed to decrease resistance in Enterococcus.
authors.forename: F
authors.initials: F
authors.lastname: Mohammadi
authors.forename: S
authors.initials: S
authors.lastname: Ghafourian
authors.forename: R
authors.initials: R
authors.lastname: Mohebi
authors.forename: M
authors.initials: M
authors.lastname: Taherikalani
authors.forename: I
authors.initials: I
authors.lastname: Pakzad
authors.forename: H
authors.initials: H
authors.lastname: Valadbeigi
authors.forename: V
authors.initials: V
authors.lastname: Hatami
authors.forename: N
authors.initials: N
authors.lastname: Sadeghifard
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D019729:Carbon-Oxygen Ligases / Q000235:genetics; D003428:Cross Infection / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D013293:Enterococcus faecalis / Q000235:genetics* / Q000302:isolation & purification; D004917:Erythromycin / Q000494:pharmacology; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology*; D006761:Hospitals; D006801:Humans; D007492:Iran; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D014640:Vancomycin / Q000494:pharmacology; D065507:Vancomycin-Resistant Enterococci / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; C071437:VanA ligase, Bacteria; D004917:Erythromycin; D014640:Vancomycin; D019729:Carbon-Oxygen Ligases