title: Relationship between Single Nucleotide Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Gene and Fatty Acid Composition in Korean Native Cattle.
abstract: The peroxisome proliferator-activated receptor gamma (PPARγ) gene plays an important role in the biosynthesis process controlled by a number of fatty acid transcription factors. This study investigates the relationships between 130 single-nucleotide polymorphisms (SNPs) in the PPARγ gene and the fatty acid composition of muscle fat in the commercial population of Korean native cattle. We identified 38 SNPs and verified relationships between 3 SNPs (g.1159-71208 A>G, g.42555-29812 G>A, and g.72362 G>T) and the fatty acid composition of commercial Korean native cattle (n = 513). Cattle with the AA genotype of g.1159-71208 A>G and the GG genotype of g.42555-29812 G>A and g.72362 G>T had higher levels of monounsaturated fatty acids and carcass traits (p<0.05). The results revealed that the 3 identified SNPs in the PPARγ gene affected fatty acid composition and carcass traits, suggesting that these 3 SNPs may improve the flavor and quality of beef in commercial Korean native cattle.
authors.affiliation: Livestock Research institute, Yeongju 750-871, Korea.
authors.forename: Jea-Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Livestock Research institute, Yeongju 750-871, Korea.
authors.forename: Jae-Jung
authors.initials: JJ
authors.lastname: Ha
authors.affiliation: Department of Equine Industry, Korea National College of Agriculture and Fisheries, Hwaseong 445-760, Korea.
authors.forename: Yong-Soo
authors.initials: YS
authors.lastname: Park
authors.affiliation: Livestock Research institute, Yeongju 750-871, Korea.
authors.forename: Jun-Koo
authors.initials: JK
authors.lastname: Yi
authors.affiliation: Biotechnology Research Center, The University of Tokyo, Bunkyo 113-8657, Tokyo.
authors.forename: Seunguk
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Korea; DKU-Theragen institute for NGS analysis (DTiNa), Cheonan 330-714, Korea.
authors.forename: Seyoung
authors.initials: S
authors.lastname: Mun
authors.affiliation: Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Korea; DKU-Theragen institute for NGS analysis (DTiNa), Cheonan 330-714, Korea.
authors.forename: Kyudong
authors.initials: K
authors.lastname: Han
authors.affiliation: School of Biotechnology, Yeungnam University, Gyeongsan 712-749, Korea.
authors.forename: J-J
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: Livestock Research institute, Yeongju 750-871, Korea.
authors.forename: Hyun-Ji
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Livestock Research institute, Yeongju 750-871, Korea.
authors.forename: Dong-Yep
authors.initials: DY
authors.lastname: Oh
keywords: Fatty Acid Composition; Korean Native Cattle; Marbling Score; PPARγ; SNP