title: Fabrication of an ionic liquid-based macroporous polymer monolithic column via atom transfer radical polymerization for the separation of small molecules.
abstract: A polymer monolithic column was prepared in a stainless steel column (50×4.6mm i.d.) via atom transfer radical polymerization technique using triallyl isocyanurate and ionic liquid (1-allyl-3-methylimidazolium chloride) as co-monomers, ethylene dimethacrylate as cross linking agent, polyethylene glycol 200, 1,4-butanediol, and N, N- dimethylformamide as porogen system, CCl4 as initiator, and FeCl2 as catalyst. The optimized polymer columns were characterized by scanning electron microscope, nitrogen adsorption-desorption instrument, mercury intrusion porosimetry, infrared spectrometer, and thermogravimetric analysis technique. Respectively, all of these factors above could illustrate that the optimized columns had relative uniform macroporous structure and high thermal stability. A series of basic and acidic small molecules, isomers, and homologues were used to evaluate the performance of these monoliths and enhanced column efficiency was obtained.
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China; College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China; College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China. Electronic address: blg@hbu.edu.cn.
authors.forename: Ligai
authors.initials: L
authors.lastname: Bai
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China; College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wei
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China; College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China.
authors.forename: Sha
authors.initials: S
authors.lastname: Liu
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China; College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China. Electronic address: lhy1610@126.com.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Liu
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China; College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, China.
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Yan
mesh_terms: D000498:Allyl Compounds / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D007093:Imidazoles / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: C544334:1-allyl-3-methylimidazolium; D000498:Allyl Compounds; D007093:Imidazoles; D052578:Ionic Liquids; D011108:Polymers
keywords: High performance liquid chromatography (HPLC); Ionic liquids (ILs); Monolithic polymer column; small molecules