title: Chronic myeloid leukemia in pregnancy: an absolute contraindication to neuraxial anesthesia?
abstract: Chronic myeloid leukemia is rare in pregnancy with an estimated incidence of 1:75000. It is a genetic myeloproliferative disorder marked by increased and unregulated growth of myeloid cells in the bone marrow. The terminal phase of chronic myeloid leukemia may develop into a blast crisis, defined as >30% myeloblasts in the circulation. A blast crisis resembles an acute leukemia and is associated with rapid clinical deterioration and short survival. Targeted gene therapy with tyrosine kinase inhibitors is effective in treatment but when these agents are discontinued, as in pregnancy, the patient may relapse and blast cells may enter the circulation. Theoretically, a central nervous system blast crisis may be induced by inadvertent intrathecal seeding of circulating blast cells, and is associated with a high mortality rate and a median life expectancy of three months. We describe the anesthetic management of a patient with chronic myeloid leukemia and blast cells in the circulation who required cesarean delivery. After considering the potential anesthetic risks and benefits, general anesthesia was chosen. Although an iatrogenic central nervous system blast crisis is extremely rare, the high morbidity and mortality associated with such an event should be considered when formulating an anesthetic plan.
authors.affiliation: Department of Anesthesiology, Loyola University Health System, Maywood, IL, USA. Electronic address: joanne.naamo@gmail.com.
authors.forename: J N
authors.initials: JN
authors.lastname: Owsiak
authors.affiliation: Department of Anesthesiology, Loyola University Health System, Maywood, IL, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Bullough
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical / Q000379:methods*; D001752:Blast Crisis / Q000473:pathology*; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology*
keywords: Cesarean delivery; Chronic myeloid leukemia; General anesthesia