title: [Role of NF-κB p65 and p38 MAPK in lung injury in rats suffered chronic intermittent hypoxia].
abstract: OBJECTIVE
  To explore the role of NF-κB p65 and p38 MAPK in lung injury in rats suffered chronic intermittent hypoxia.
  
  
  METHODS
  Experiment were divided into a control group and a hypoxia group (n=20). After 5 weeks of hypoxia treatment, the expression of NF-κB p65 and p38 MAPK in lung tissues of rats were detected by optical microscope and immunohistochemical techniques and Western blot.
  
  
  RESULTS
  Pathological examination showed pulmonary interval thickness was (0.45 ± 0.12) μm and (2.15 ± 0.49) μm in the control and hypoxia group, respectively (P<0. 05). Compared with the control group, the levels of both NF-κB p65 and p38 MAPK were increased in the hypoxia group (P<0. 01), which were confirmed by Western blot.
  
  
  CONCLUSIONS
  NF-κB p65 and p38 MAPK may play important roles in lung injury reconstruction in of the rats treated by chronic intermittent hypoxia.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The First Hospital Affiliated to Xi'an Medical University, Xi'an 710077, China.
authors.forename: Liqiao
authors.initials: L
authors.lastname: Ge
authors.affiliation: Department of Anesthesia, The First Hospital Affiliated to Xi'an Medical University, Xi'an 710077, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Ming
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Infection Control, The First Hospital Affiliated to Xi'an Medical University, Xi'an 710077, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The First Hospital Affiliated to Xi'an Medical University, Xi'an 710077, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Qiao
mesh_terms: D000818:Animals; D015153:Blotting, Western; D000860:Hypoxia / Q000503:physiopathology*; D008168:Lung / Q000378:metabolism / Q000473:pathology; D055370:Lung Injury / Q000378:metabolism / Q000503:physiopathology*; D051381:Rats; D051996:Transcription Factor RelA / Q000378:metabolism*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: C498145:Rela protein, rat; D051996:Transcription Factor RelA; D048051:p38 Mitogen-Activated Protein Kinases