title: Myeloid-derived suppressor cells mediate immune suppression in spinal cord injury.
abstract: Spinal cord injury (SCI) is characterized by the loss of motor and sensory functions in areas below the level of the lesion and numerous accompanying deficits. Previous studies have suggested that myeloid-derived suppressor cell (MDSC)-induced immune depression may play a pivotal role in the course of SCI. However, the concrete mechanism of these changes regarding immune suppression remains unknown. Here, we created an SCI mouse model to gain further evidence regarding the relationship between MDSCs following SCI and T lymphocyte suppression. We showed that in the SCI mouse model, the expanding MDSCs have the capacity to suppress T cell proliferation, and this suppression could be reversed by blocking the arginase.
authors.affiliation: Department of General Surgery, Beijing Charity Hospital, China Rehabilitation Research Center, Rehabilitation College of Capital Medical University, Beijing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Beijing Charity Hospital, China Rehabilitation Research Center, Rehabilitation College of Capital Medical University, Beijing, China.
authors.forename: Wei-bo
authors.initials: WB
authors.lastname: Yu
authors.affiliation: Department of General Surgery, Peking University Third Hospital, Beijing, China.
authors.forename: Lian-yuan
authors.initials: LY
authors.lastname: Tao
authors.affiliation: Department of General Surgery, Beijing Charity Hospital, China Rehabilitation Research Center, Rehabilitation College of Capital Medical University, Beijing, China. Electronic address: yinyufeng@yeah.net.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
mesh_terms: D000818:Animals; D007108:Immune Tolerance / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D022423:Myeloid Cells / Q000276:immunology*; D013119:Spinal Cord Injuries / Q000276:immunology* / Q000517:prevention & control
keywords: Immune suppression; Myeloid-derived suppressor cells; Spinal cord injury; T cells