title: The effect of desensitizing dentifrices on dentin wear and tubule occlusion.
abstract: OBJECTIVE
  To evaluate the effect of desensitizing dentifrices on dentin erosive wear, using a 5-day erosion-abrasion-remineralization cycling model. The effect of the dentifrices on dentin's tubule occlusion was also investigated.
  
  
  METHODS
  30 samples of root dentin were randomly divided into three groups (n = 10): (1) Colgate Total 12 Clean Mint (control, 1,450 ppm F); (2) Colgate Sensitive Pro-Relief (1,450 ppm F, Pro-Argin); and (3) Sensodyne Repair&Protect (1,450 ppm F, Novamin). Erosion was performed with a cola drink, for 5 minutes, 4x/day. Toothbrushing with the slurry dentifrices (1:2) was performed 2x/day, with electric toothbrushes, using standard pressure for 15 seconds. Surface loss (SL) was determined with optical profilometry at baseline and after the first, third and fifth days of cycling. Before treatment and in the end of the cycling, the amount of opened dentin tubules per area was evaluated in three randomly selected specimens from each group, by environmental scanning electron microscopy. The relative dentin abrasitivity (RDA) of the dentifrices was also measured. Data were statistically analyzed (α = 0.05).
  
  
  RESULTS
  All the dentifrices showed a progressive increase in SL over time. However, no significant differences in SL among the dentifrices were observed at any time studied. Sensodyne Repair&Protect significantly reduced the number of opened dentin tubules when compared to the other groups. Colgate Total 12 Clean Mint showed the highest RDA, followed by Sensodyne Repair&Protect and then by Colgate Sensitive Pro-Relief. The desensitizing dentifrices tested produced a similar rate of erosive dentin wear to the conventional dentifrice; however, only Sensodyne Repair&Protect was able to promote tubule occlusion.
authors.forename: Raquel Marianna
authors.initials: RM
authors.lastname: Lopes
authors.forename: Miriam Lacalle
authors.initials: ML
authors.lastname: Turbino
authors.forename: Denise Maria
authors.initials: DM
authors.lastname: Zezell
authors.forename: Tais
authors.initials: T
authors.lastname: Scaramucci
authors.forename: Ana Cecilia Corrêa
authors.initials: AC
authors.lastname: Aranha
mesh_terms: D001120:Arginine / Q000494:pharmacology; D002119:Calcium Carbonate / Q000494:pharmacology; D002253:Carbonated Beverages / Q000009:adverse effects; D003802:Dentifrices / Q000494:pharmacology*; D003804:Dentin / Q000187:drug effects* / Q000648:ultrastructure; D057133:Dentin Desensitizing Agents / Q000494:pharmacology*; D004338:Drug Combinations; D005459:Fluorides / Q000494:pharmacology; D005898:Glass; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D009566:Nitrates / Q000494:pharmacology; D010710:Phosphates / Q000494:pharmacology; D011897:Random Allocation; D012824:Silicic Acid / Q000494:pharmacology; D014072:Tooth Abrasion / Q000209:etiology; D014077:Tooth Erosion / Q000209:etiology; D014089:Tooth Remineralization; D014092:Tooth Root / Q000187:drug effects / Q000648:ultrastructure; D057085:Tooth Wear / Q000209:etiology*; D014099:Toothbrushing / Q000295:instrumentation; D014100:Toothpastes / Q000494:pharmacology
chemical_list: D003802:Dentifrices; D057133:Dentin Desensitizing Agents; D004338:Drug Combinations; D009566:Nitrates; C510984:NovaMin; D010710:Phosphates; C097427:Sensodyne; D014100:Toothpastes; C546060:hydrated silica gel-based toothpaste; C585805:pro-argin; D012824:Silicic Acid; D001120:Arginine; D002119:Calcium Carbonate; D005459:Fluorides