title: Pleomorphic lipoma: A gentle giant of pathology.
abstract: Pleomorphic lipoma is a relatively rare adipocytic neoplasm, occurring predominantly in elderly males in the subcutaneous tissues of the neck or shoulder. To the best of our knowledge, only five cases have been reported in which the lesion was intramuscular. We hereby report a case of a 60-year-old female patient, presenting with an intramuscular, posterior shoulder mass. The aspirate showed a giant cell-rich lesion, admixed with short, plump-looking, spindly cells. There was no overt evidence of malignancy; however, the cell cytology was sufficiently atypical to warrant concern. Subsequent excision revealed a classical pleomorphic lipoma on histology with no evidence of malignancy. CD34 staining by immunohistochemistry further supported the diagnosis. Differential diagnosis and the cytological diagnostic pitfalls of pleomorphic lipomas have been discussed with a review of the literature.
authors.affiliation: Department of Pathology, Prince Aly Khan Hospital, Mumbai, Maharashtra, India.
authors.forename: Uma
authors.initials: U
authors.lastname: Sakhadeo
authors.affiliation: Department of Pathology, Prince Aly Khan Hospital, Mumbai, Maharashtra, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Mundhe
authors.affiliation: Department of Pathology, Prince Aly Khan Hospital, Mumbai, Maharashtra, India.
authors.forename: Maria A
authors.initials: MA
authors.lastname: DeSouza
authors.affiliation: Department of Pathology, Prince Aly Khan Hospital, Mumbai, Maharashtra, India.
authors.forename: Roshan F
authors.initials: RF
authors.lastname: Chinoy
keywords: Bizarre cells; intramuscular; pleomorphic lipoma