title: Two-Dimensional, pH-Responsive Oligoglycine-Based Nanocarriers.
abstract: The nanocarrier capabilities of atomically smooth two-dimensional sheets of a biantennary oligoglycine peptide C8H16(-CH2-NH-Gly5)2 (also called tectomers) are demonstrated. We show that the pH-controlled, rapid, and reversible assembly and disassembly of oligoglycine can be effectively used for controlled loading and release of the anticancer drug and fluorescent probe coralyne. The calculated partition coefficient in water is of the same order of magnitude or higher when compared to other nanocarriers such as liposomes and micelles, signifying the tectomer's impressive loading capabilities. Moreover, the loading of guest molecules in tectomers facilitates the protection from rapid photochemically induced degradation. Such efficient, pH-sensitive, stable, and biocompatible nanocarriers are extremely attractive for biosensing, therapeutic, and theranostic applications. Additionally, our results suggest that these planar self-assembled materials can also act as phase-transfer vehicles for hydrophobic cargoes further broadening their biomedical and technological applications.
authors.affiliation: Departamento de Química Física, Universidad de Zaragoza , 50009 Zaragoza, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Garriga
authors.affiliation: Department of Physics, Faculty of Engineering & Physical Sciences, University of Surrey , Guildford GU2 7XH, United Kingdom.
authors.forename: Izabela
authors.initials: I
authors.lastname: Jurewicz
authors.affiliation: Instituto de Carboquímica ICB-CSIC , Miguel Luesma Castán 4, 50018 Zaragoza, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Romero
authors.affiliation: Instituto de Carboquímica ICB-CSIC , Miguel Luesma Castán 4, 50018 Zaragoza, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Jarne
authors.affiliation: Instituto de Carboquímica ICB-CSIC , Miguel Luesma Castán 4, 50018 Zaragoza, Spain.
authors.forename: Vicente L
authors.initials: VL
authors.lastname: Cebolla
authors.affiliation: Department of Physics, Faculty of Engineering & Physical Sciences, University of Surrey , Guildford GU2 7XH, United Kingdom.
authors.forename: Alan B
authors.initials: AB
authors.lastname: Dalton
authors.affiliation: Instituto de Carboquímica ICB-CSIC , Miguel Luesma Castán 4, 50018 Zaragoza, Spain.
authors.forename: Edgar
authors.initials: E
authors.lastname: Muñoz
mesh_terms: D001600:Berberine Alkaloids / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010455:Peptides / Q000737:chemistry*; D012995:Solubility; D012996:Solutions; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D019207:beta Carotene / Q000494:pharmacology
chemical_list: D001600:Berberine Alkaloids; D004337:Drug Carriers; D010455:Peptides; D012996:Solutions; D019207:beta Carotene; C011080:polyglycine; C000666:coralyne
keywords: fluorescence; nanocarriers; oligoglycine; pH-controlled release; tectomers