title: Clinical and pathologic diagnosis and different diagnosis of syphilis cervical lymphadenitis.
abstract: OBJECTIVE
  To study the clinical pathologic characteristics and differential diagnosis of syphilitic cervical lymphadenitis, and to improve the rate of its diagnosis and treatment.
  
  
  METHODS
  Retrospectively analyzed the clinical history, Trepone pallidum-ELISA (TP-ELISA), rapid plasma regain test (RPR) and routine pathological examination of the patient diagnosed as syphilis lymphadenitis. And review related literatures.
  
  
  RESULTS
  The main clinical presentation was multiple palpable cervical lymph nodes. The multiple nodes were hard, fixed, and the major diameter of the larger one was 2 cm. The main pathological changes included: the capsule was significantly thickened; reactive hyperplasia of lymphoid follicular with sky star phenomenon; occlusive endovasculitis; perivascular inflammation; the proliferation of epithelioid histiocytes can form granulomas with few multinucleated giant cells; few necrosis. TP-ELISA and RPR were positive.
  
  
  CONCLUSIONS
  The pathological changes of syphilitic lymphadenitis have a variety of performance with relatively specific and suggestive alterations which requires a combination of clinical history and laboratory test before the diagnosis, and the clinicians can reduce misdiagnosis and missed diagnosis of the disease by increasing vigilance of it.
authors.affiliation: Department of Pathology, Anyang Tumor Hospital Anyang 455000, Henan, China.
authors.forename: Yufen
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Dermatology and Venerology, Anyang County Hospital of Traditional Chinese Anyang 455000, China.
authors.forename: Xinlian
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Anyang Tumor Hospital Anyang 455000, Henan, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Xu
authors.affiliation: Department of Pathology, Anyang Tumor Hospital Anyang 455000, Henan, China.
authors.forename: Libo
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Laboratory, Anyang Tumor Hospital Anyang 455000, Henan, China.
authors.forename: Fangchao
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Pathology, Anyang Tumor Hospital Anyang 455000, Henan, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Anyang Tumor Hospital Anyang 455000, Henan, China.
authors.forename: Lanfang
authors.initials: L
authors.lastname: Miao
authors.affiliation: Department of Pathology, Anyang Tumor Hospital Anyang 455000, Henan, China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Yang
mesh_terms: D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007249:Inflammation; D008198:Lymph Nodes / Q000473:pathology; D008199:Lymphadenitis / Q000175:diagnosis* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000473:pathology; D009336:Necrosis / Q000473:pathology; D012189:Retrospective Studies; D013587:Syphilis / Q000175:diagnosis* / Q000382:microbiology; D013588:Syphilis Serodiagnosis; D014210:Treponema pallidum / Q000276:immunology*
keywords: Syphilis; clinical; diagnosis; lymphadenitis; pathologic