title: Relationship of plasma matrix metalloproteinase-9 and hematoma expansion in acute hypertensive cerebral hemorrhage.
abstract: In the present study, we aimed to investigate the relationship of plasma matrix metalloproteinase-9 (MMP-9) and hematoma expansion (HE) in acute hypertensive cerebral hemorrhage (AHCH) (HE-in-AHCH). Patients with hypertensive cerebral hemorrhage, confirmed by head computed tomography (CT) within 12 h of onset, were prospectively collected. Venous blood was sampled within 4 h of the confirmation to determine the serum MMP-9 concentration. The blood pressure and National Institute of Health Stroke Score of the patients were recorded on hospital admission. CT re-scanning was performed within 42-54 h of the first head CT examination or immediately after worsening of the patients' consciousness disorder. The relationship between MMP-9 level and HE was analyzed. A total of 186 patients were included. Of these patients, 41 had HE (22.0%). Multivariate logistic regression analysis showed that, in addition to the short interval between onset and the first CT examination, and the irregularity of hematoma shape, increasing MMP-9 level was an independent risk factor for HE-in-AHCH (OR value = 15.65, 95% CI: 5.30-46.15). Moreover, increasing plasma MMP-9 level was identified as an independent risk factor in patients with HE-in-AHCH.
authors.affiliation: a Department of Neurology , Affiliated Zhongshan Hospital of Xiamen University , Xiamen China.
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Yang
authors.affiliation: a Department of Neurology , Affiliated Zhongshan Hospital of Xiamen University , Xiamen China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Zhuang
authors.affiliation: a Department of Neurology , Affiliated Zhongshan Hospital of Xiamen University , Xiamen China.
authors.forename: Feng
authors.initials: F
authors.lastname: Peng
authors.affiliation: a Department of Neurology , Affiliated Zhongshan Hospital of Xiamen University , Xiamen China.
authors.forename: Weihong
authors.initials: W
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000150:complications / Q000473:pathology; D005260:Female; D006406:Hematoma / Q000097:blood* / Q000150:complications / Q000473:pathology; D006801:Humans; D020299:Intracranial Hemorrhage, Hypertensive / Q000097:blood* / Q000150:complications / Q000473:pathology; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D020780:Matrix Metalloproteinase 9
keywords: hematoma expansion; hypertensive; intracranial hemorrhage; matrix metalloproteinase-9