title: Tuning the properties of a novel short cell-penetrating peptide by intramolecular cyclization with a triazole bridge.
abstract: Cell-penetrating peptides (CPPs) present a versatile alternative to viral gene delivery vectors, addressing the still challenging task to suitably transport the desired gene to the target cell. In this work, the rational design of triazole-bridged CPPs and their detailed investigation concerning peptide/lipid interactions, using also NMR-based structure calculations, are reported.
authors.affiliation: Department of Chemistry, Institute of Biochemistry, 50674 Cologne, Germany. ines.neundorf@uni-koeln.de.
authors.forename: M
authors.initials: M
authors.lastname: Horn
authors.affiliation: Department of Chemistry, Institute of Biochemistry, 50674 Cologne, Germany. ines.neundorf@uni-koeln.de.
authors.forename: F
authors.initials: F
authors.lastname: Reichart
authors.affiliation: Department of Chemistry, Institute of Biochemistry, 50674 Cologne, Germany. ines.neundorf@uni-koeln.de.
authors.forename: S
authors.initials: S
authors.lastname: Natividad-Tietz
authors.affiliation: Department of Chemistry, Organic Chemistry, 50939 Cologne, Germany. mdiazher@uni-koeln.de.
authors.forename: D
authors.initials: D
authors.lastname: Diaz
authors.affiliation: Department of Chemistry, Institute of Biochemistry, 50674 Cologne, Germany. ines.neundorf@uni-koeln.de.
authors.forename: I
authors.initials: I
authors.lastname: Neundorf
mesh_terms: D003500:Cyclization; D010455:Peptides / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D010455:Peptides; D014230:Triazoles