title: Neuropeptide Y protects kidney against cisplatin-induced nephrotoxicity by regulating p53-dependent apoptosis pathway.
abstract: Cisplatin is a platinum-based chemotherapeutic drug for treating various types of cancers. However, the use of cisplatin is limited by its negative effect on normal tissues, particularly nephrotoxicity. Various mechanisms such as DNA adduct formation, mitochondrial dysfunction, oxidative stress, and apoptosis are involved in the adverse effect induced by cisplatin treatment. Several studies have suggested that neuropeptide Y (NPY) is involved in neuroprotection as well as restoration of bone marrow dysfunction from chemotherapy induced nerve injury. However, the role of NPY in chemotherapy- induced nephrotoxicity has not been studied. Here, we show that NPY rescues renal dysfunction by reducing the expression of pro-apoptotic proteins in cisplatin induced nephrotoxicity through Y1 receptor, suggesting that NPY can protect kidney against cisplatin nephrotoxicity as a possible useful agent to prevent and treat cisplatin-induced nephrotoxicity. [BMB Reports 2016; 49(5): 288-292].
authors.affiliation: Stem Cell Neuroplasticity Research Group, Kyungpook National University; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University; Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu 41944, Korea.
authors.forename: Namoh
authors.initials: N
authors.lastname: Kim
authors.affiliation: Department of Orthopaedic Surgery, Kyungpook National University Hospital, Daegu 41944, Korea.
authors.forename: Woo-Kie
authors.initials: WK
authors.lastname: Min
authors.affiliation: Stem Cell Neuroplasticity Research Group, Kyungpook National University; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University; Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu 41944, Korea.
authors.forename: Min Hee
authors.initials: MH
authors.lastname: Park
authors.affiliation: Stem Cell Neuroplasticity Research Group, Kyungpook National University; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University; Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu 41944, Korea.
authors.forename: Jong Kil
authors.initials: JK
authors.lastname: Lee
authors.affiliation: Stem Cell Neuroplasticity Research Group, Kyungpook National University; Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu 41944, Korea.
authors.forename: Hee Kyung
authors.initials: HK
authors.lastname: Jin
authors.affiliation: Stem Cell Neuroplasticity Research Group, Kyungpook National University; Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University; Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu 41944, Korea.
authors.forename: Jae-Sung
authors.initials: JS
authors.lastname: Bae
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002945:Cisplatin / Q000009:adverse effects*; D015536:Down-Regulation / Q000187:drug effects; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D008810:Mice, Inbred C57BL; D009478:Neuropeptide Y / Q000494:pharmacology / Q000627:therapeutic use*; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017476:Receptors, Neuropeptide Y / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D009478:Neuropeptide Y; D020011:Protective Agents; D017476:Receptors, Neuropeptide Y; D016159:Tumor Suppressor Protein p53; C097212:neuropeptide Y-Y1 receptor; D002945:Cisplatin