title: Disparate Metabolic Responses in Mice Fed a High-Fat Diet Supplemented with Maize-Derived Non-Digestible Feruloylated Oligo- and Polysaccharides Are Linked to Changes in the Gut Microbiota.
abstract: Studies have suggested links between colonic fermentation of dietary fibers and improved metabolic health. The objectives of this study were to determine if non-digestible feruloylated oligo- and polysaccharides (FOPS), a maize-derived dietary fiber, could counteract the deleterious effects of high-fat (HF) feeding in mice and explore if metabolic benefits were linked to the gut microbiota. C57BL/6J mice (n = 8/group) were fed a low-fat (LF; 10 kcal% fat), HF (62 kcal% fat), or HF diet supplemented with FOPS (5%, w/w). Pronounced differences in FOPS responsiveness were observed: four mice experienced cecal enlargement and enhanced short chain fatty acid production, indicating increased cecal fermentation (F-FOPS). Only these mice displayed improvements in glucose metabolism compared with HF-fed mice. Blooms in the gut microbial genera Blautia and Akkermansia were observed in three of the F-FOPS mice; these shifts were associated with reductions in body and adipose tissue weights compared with the HF-fed control mice. No improvements in metabolic markers or weights were detected in the four mice whose gut microbiota did not respond to FOPS. These findings demonstrate that FOPS-induced improvements in weight gain and metabolic health in mice depended on the ability of an individual's microbiota to ferment FOPS.
authors.affiliation: Department of Food Science & Technology, University of Nebraska-Lincoln, Lincoln, NE, United States of America.
authors.forename: Junyi
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Food Science & Technology, University of Nebraska-Lincoln, Lincoln, NE, United States of America.
authors.forename: Laure B
authors.initials: LB
authors.lastname: Bindels
authors.affiliation: Department of Food Science & Technology, University of Nebraska-Lincoln, Lincoln, NE, United States of America.
authors.forename: Rafael R
authors.initials: RR
authors.lastname: Segura Munoz
authors.affiliation: Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
authors.forename: Inés
authors.initials: I
authors.lastname: Martínez
authors.affiliation: Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, AB, Canada.|Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada.
authors.forename: Jens
authors.initials: J
authors.lastname: Walter
authors.affiliation: Department of Food Science & Technology, University of Nebraska-Lincoln, Lincoln, NE, United States of America.
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Ramer-Tait
authors.affiliation: Department of Food Science & Technology, University of Nebraska-Lincoln, Lincoln, NE, United States of America.|Department of Agronomy & Horticulture, University of Nebraska-Lincoln, Lincoln, NE, United States of America.
authors.forename: Devin J
authors.initials: DJ
authors.lastname: Rose
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D059305:Diet, High-Fat; D004043:Dietary Fiber / Q000494:pharmacology*; D005232:Fatty Acids, Volatile / Q000378:metabolism; D000069196:Gastrointestinal Microbiome / Q000187:drug effects* / Q000502:physiology; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D011134:Polysaccharides / Q000494:pharmacology; D003313:Zea mays
chemical_list: D004043:Dietary Fiber; D005232:Fatty Acids, Volatile; D011134:Polysaccharides