title: [Peripheral T-Cell Lymphoma, Not Otherwise Specified Occurring After the Treatment of Relapsed Follicular Lymphoma].
abstract: A 77-year-old-man was diagnosed with follicular lymphoma (FL), grade 3A. After six courses of R-THP-COP (rituximab, pirarubicin, cyclophosphamide, vincristine and prednisolone) therapy, he achieved complete remission (CR). He achieved a second CR after radiotherapy, a third CR after six courses of bendamustine /rituximab (BR) therapy, and a fourth CR after six courses of BR therapy. However 2 months after the last chemotherapy, his tumor progressed rapidly and he died. Autopsy results showed medium and large lymphoid cells with pleomorphic, irregular nuclei and prominent nucleoli infiltrated in multiple lymph nodes, the liver, the lung, and the spleen. The lymphoid cells were positive for CD3, CD8, granzymeB, TIA-1 and negative for CD4, CD20, CD79a, CD10, and CD56. Autopsy diagnosis was peripheral T-cell lymphoma, not otherwise specified. Occurrence of lymphoma in T-cell lineage should be considered, if the course of low-grade B-cell lymphomas, such as FL rapidly progresses.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Fukushima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Inoue
authors.forename: Naomi
authors.initials: N
authors.lastname: Ishi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Okuno
authors.forename: Reika
authors.initials: R
authors.lastname: Son
authors.forename: Chiaki
authors.initials: C
authors.lastname: Soejima
authors.forename: Mirei
authors.initials: M
authors.lastname: Horiuchi
authors.forename: Hideya
authors.initials: H
authors.lastname: Ueda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshida
authors.forename: Kiyoyuki
authors.initials: K
authors.lastname: Hagihara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kanashima
authors.forename: Takafumi
authors.initials: T
authors.lastname: Nakao
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamane
mesh_terms: D000368:Aged; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D008224:Lymphoma, Follicular; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D060787:Neoplasm Grading; D012008:Recurrence