title: Laparoscopic right hemicolectomy: short- and long-term outcomes of intracorporeal versus extracorporeal anastomosis.
abstract: The use of laparoscopy for right hemicolectomy has gained popularity allowing the option of a totally laparoscopic intracorporeal anastomosis (IA) for intestinal reconstruction. This technique may alleviate some of the technical limitations that a surgeon faces with a laparoscopic-assisted extracorporeal anastomosis (EA).
  
  
  
  A retrospective chart review of 195 consecutive patients who underwent laparoscopic right hemicolectomy by four colorectal surgeons at three institutions from March 2005 to June 2014 was performed. Multivariate regression analysis was used to compare postoperative and oncologic outcomes.
  
  
  
  A total of 195 patients underwent laparoscopic right hemicolectomy over the study period, with 86 (44 %) patients receiving IA and 109 (56 %) patients receiving an EA. The most common indication for surgery in both groups was cancer: 56 (65 %) of IA cases and 57 (52 %) of EA cases. IA had a significantly higher rate of minor complications but no difference in serious complications compared to EA. Conversion to open resection was higher in EA. Using multivariate analysis to compare IA versus EA, there was no significant difference in length of stay, return of bowel function, risk of anastomotic leak, risk of intraabdominal abscess or risk of wound complications. Amongst cancer resections, there was no significant difference in the median number of lymph nodes harvested (18 LNs in IA group vs. 19 LNs in EA group, P > 0.05). There was also no significant difference in overall survival and disease-free survival at 5.7 years between the two groups.
  
  
  
  IA in laparoscopic right hemicolectomy is associated with similar postoperative and oncologic outcomes compared to EA. IA may possess advantages in terms of conversion and flexibility of specimen extraction, but this is counterbalanced by a higher incidence of minor complications. These findings suggest that IA represents a valid technique in the arsenal of the experienced colorectal surgeon without compromising outcomes.
authors.affiliation: Department of Surgery, University of California, Irvine School of Medicine, 333 City Blvd. West Suite 850, Orange, CA, 92868, USA. markhh@uci.edu.
authors.forename: Mark H
authors.initials: MH
authors.lastname: Hanna
authors.affiliation: Department of Surgery, University of Southern California, Los Angeles, CA, USA.
authors.forename: Grace S
authors.initials: GS
authors.lastname: Hwang
authors.affiliation: Department of Statistics, University of California Irvine, Irvine, CA, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Phelan
authors.affiliation: Department of Surgery, University of California, Irvine School of Medicine, 333 City Blvd. West Suite 850, Orange, CA, 92868, USA.
authors.forename: Thanh-Lan
authors.initials: TL
authors.lastname: Bui
authors.affiliation: Department of Surgery, University of California, Irvine School of Medicine, 333 City Blvd. West Suite 850, Orange, CA, 92868, USA.
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Carmichael
authors.affiliation: Department of Surgery, University of California, Irvine School of Medicine, 333 City Blvd. West Suite 850, Orange, CA, 92868, USA.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Mills
authors.affiliation: Department of Surgery, University of California, Irvine School of Medicine, 333 City Blvd. West Suite 850, Orange, CA, 92868, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Stamos
authors.affiliation: Department of Surgery, University of California, Irvine School of Medicine, 333 City Blvd. West Suite 850, Orange, CA, 92868, USA.
authors.forename: Alessio
authors.initials: A
authors.lastname: Pigazzi
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical / Q000379:methods*; D003082:Colectomy / Q000379:methods*; D003110:Colonic Neoplasms / Q000601:surgery; D061887:Conversion to Open Surgery; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000601:surgery; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
keywords: Intracorporeal anastomosis; Laparoscopy; Outcomes; Right hemicolectomy