title: The Clinicopathological Features and Long-Term Survival Outcomes of Mucinous Gastric Carcinoma: a Consecutive Series of 244 Cases from a Single Institute.
abstract: OBJECTIVE
  Mucinous gastric carcinoma (MGC) is a rare kind of malignancy with unclear prognosis. This study aims to assess the clinicopathological features and prognosis of MGC.
  
  
  METHODS
  We retrospectively analyzed a consecutive series of 244 MGC patients who underwent radical gastrectomy with D2 lymphadenectomy, and compared the data with 260 gastric signet ring cell carcinoma (SRC) patients.
  
  
  RESULTS
  The univariate survival analysis showed that the surgical types, diameter of the primary tumor, the Borrmann type, pathological depth of tumor invasion (pT), pathological number of metastatic lymph node (pN), pathological tumor lymph metastasis (pTNM), and vascular invasion were all significant predictors of survival (all P < 0.05). The multivariate survival analysis revealed that the diameter of the tumor, the Borrmann type, pT, pTNM stage, and vascular invasion as an independent predictive factor of survival (all P < 0.05). Compared with the SRC group, the MGC group had more male patients, more elder patients, larger tumor diameter, more T3 and T4 invasion to the gastric wall, more patients with metastatic lymph nodes, more pTNM stage III, and less Borrmann type 1. The overall survival rate of patients with MGC was significantly lower than that of patients with SRC (P < 0.001).
  
  
  CONCLUSIONS
  MGC was an aggressive malignancy which had unique clinicopathological features.
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 17, South of Pan Jiayuan Street, Chaoyang District, Beijing, China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 17, South of Pan Jiayuan Street, Chaoyang District, Beijing, China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 17, South of Pan Jiayuan Street, Chaoyang District, Beijing, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Che
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 17, South of Pan Jiayuan Street, Chaoyang District, Beijing, China.
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Lan
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 17, South of Pan Jiayuan Street, Chaoyang District, Beijing, China.
authors.forename: Yingtai
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 17, South of Pan Jiayuan Street, Chaoyang District, Beijing, China. wangcf369@medmail.com.cn.
authors.forename: Chengfeng
authors.initials: C
authors.lastname: Wang
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001808:Blood Vessels / Q000473:pathology; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D047368:Tumor Burden
keywords: Gastric carcinoma; Mucinous carcinoma; Prognosis; Signet ring cell carcinoma; Surgery