title: Stem cells, telomerase regulation and the hypoxic state.
abstract: The cellular response to a hypoxic environment is regulated by hypoxia inducible factors. Hypoxia inducible factor 1 alpha (Hif1alpha) in particular, is tightly regulated by the hypoxic environment in most cells, and plays an important role in regulating the stress response of cells to hypoxia. Interestingly, substantial observations are now emerging that point to an important role for Hif1alpha in stem cells, including embryonic stem cells, neuronal stem cells and hematopoietic stem cells. Notably, Hif1alpha has been shown to enhance self renewal of stem cells, mediate a shift to glycolytic metabolism, and promote telomerase expression.
authors.affiliation: Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawai'i, 651 Ilalo Street, Honolulu, HI.
authors.forename: Juanita
authors.initials: J
authors.lastname: Mathews
authors.affiliation: 1.
authors.forename: Philip M C
authors.initials: PM
authors.lastname: Davy
authors.affiliation: Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawai'i, 651 Ilalo Street, Honolulu, HI.
authors.forename: Lauren H
authors.initials: LH
authors.lastname: Gardner
authors.affiliation: 651 Ilalo St. BSB Room 163B, University of Hawai'i, Honolulu, HI, 96813, allsopp@hawaii.edu.
authors.forename: Richard C
authors.initials: RC
authors.lastname: Allsopp
mesh_terms: D015687:Cell Hypoxia; D016922:Cellular Senescence; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000502:physiology; D013234:Stem Cells / Q000166:cytology* / Q000201:enzymology; D019098:Telomerase / Q000378:metabolism*
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D019098:Telomerase