title: Analogues of boswellic acids as inhibitors of pro-inflammatory cytokines TNF-α and IL-6.
abstract: A library of boswellic acid analogues were synthesized and tested for their anti-inflammatory potential on key inflammatory mediators, TNF-α and IL-6. The study led to the identification of lead compounds showing significant inhibition of the cytokines, TNF-α and IL-6 both in vitro and in vivo.
authors.affiliation: Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India.
authors.forename: Simmi
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India.
authors.forename: Shilpa
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India.
authors.forename: Vidushi
authors.initials: V
authors.lastname: Khajuria
authors.affiliation: Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India.
authors.forename: Asha
authors.initials: A
authors.lastname: Bhagat
authors.affiliation: Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India. Electronic address: zahmed@iiim.ac.in.
authors.forename: Zabeer
authors.initials: Z
authors.lastname: Ahmed
authors.affiliation: Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India; Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India. Electronic address: bashah@iiim.ac.in.
authors.forename: Bhahwal Ali
authors.initials: BA
authors.lastname: Shah
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D015850:Interleukin-6 / Q000276:immunology; D051379:Mice; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000276:immunology; D000093242:Interleukin-6 Inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D014315:Triterpenes; D014409:Tumor Necrosis Factor-alpha; D000093242:Interleukin-6 Inhibitors; C054625:boswellic acid
keywords: Anti-inflammatory; Cytokine; IL-6; TNF-α; β-Boswellic acid