title: Overexpression of ADAMTS5 can regulate the migration and invasion of non-small cell lung cancer.
abstract: Non-small cell lung cancer (NSCLC) is the major cause of cancer-related lethality among human cancer patients globally, and the poor prognosis of this cancer is mainly explained by metastasis, so it is essential to find out the molecule mechanisms and a novel therapeutic for NSCLC. A disintegrin and metalloprotease with thrombospondin motif 5 (ADAMTS5) belongs to the protease family. It has been reported to participate in tumor migration and invasion. In this study, we showed that the expression of ADAMTS5 was higher in lung cancer tissues by Western blot. The immunohistochemistry analysis was performed in 140 NSCLC cases, and the result indicated that ADAMTS5 was significantly associated with clinical pathologic variables. The Kaplan-Meier curve showed that the high expression of ADAMTS5 was related to poor prognosis of lung cancer patients. Wound healing assays and transwell migration assays revealed that the high expression of ADAMTS5 promoted the migration and invasion of NSCLC. In a word, our findings suggest that ADAMTS5 can regulate the migration and invasion of NSCLC and it may be a useful target of therapy in NSCLC.
authors.affiliation: Department of Respiratory, The First Affiliated Hospital of Soochow University, Suzhou, China.|Department of Respiratory, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Gu
authors.affiliation: Department of Oncology, Jiangyin People's Hospital, Jiangyin, China.|Department of Oncology, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Respiratory, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Feng
authors.affiliation: Department of Pathology, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Xue
authors.affiliation: Department of Oncology, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Guoxin
authors.initials: G
authors.lastname: Mao
authors.affiliation: Department of Oncology, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Gai
authors.affiliation: Department of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Xiaoning
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Respiratory, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Jialin
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Department of Respiratory, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Oncology, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Mengting
authors.initials: M
authors.lastname: Shao
authors.affiliation: Department of Oncology, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
authors.affiliation: Department of Respiratory, The First Affiliated Hospital of Soochow University, Suzhou, China. huangjianannt@126.com.
authors.forename: Jianan
authors.initials: J
authors.lastname: Huang
mesh_terms: D000071116:ADAMTS5 Protein / Q000378:metabolism*; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015153:Blotting, Western; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D016022:Case-Control Studies; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D005455:Fluorescent Antibody Technique; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007124:Immunoenzyme Techniques; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D014407:Tumor Cells, Cultured
chemical_list: D014408:Biomarkers, Tumor; D000071116:ADAMTS5 Protein; C121532:ADAMTS5 protein, human
keywords: ADAMTS5; Invasion; Migration; Non-small cell lung cancer