title: [β-Catenin: Structure, Function and Role in Malignant Transformation of Epithelial Cells].
abstract: The article presents the data on the structure and mechanisms of β-catenin functioning. The basic aspects of the role of β-catenin in malignant transformation have been studied at various tumors. Primary structure of β-catenin allows it to interact with many factors and ligands, including transcription factors, α-catenin, cadherin, Axin, Rho family GTPases, Bcl9 et al. This interaction is the base for β-catenin's intracellular multi-functioning. The review presents data on the participation of β-catenin in the mechanisms of adhesion, regulation of RNA metabolism, formation contacts with the cytoskeleton and its role in the canonical Wnt signaling pathway, marked examples pro-inflammatory and anti-inflammatory effects of β-catenin. The β-catenin involvement in malignant transformation and progression of certain tumors is not in doubt. The data on the changes in β-catenin expression in the given examples of colon cancer, prostate cancer, different forms of thyroid cancer and hepatocellular carcinoma are presented with the prospects of its use as a marker and a predictor of malignant transformation. Continued research in this area will not only make use of β-catenin as a potential predictor of malignant tumors, but also to develop approaches to targeted therapy.
authors.forename: A V
authors.initials: AV
authors.lastname: Isaeva
authors.forename: A P
authors.initials: AP
authors.lastname: Zima
authors.forename: I P
authors.initials: IP
authors.lastname: Shabalova
authors.forename: N V
authors.initials: NV
authors.lastname: Ryazantseva
authors.forename: O A
authors.initials: OA
authors.lastname: Vasil'eva
authors.forename: K T
authors.initials: KT
authors.lastname: Kasoayn
authors.forename: T V
authors.initials: TV
authors.lastname: Saprina
authors.forename: V N
authors.initials: VN
authors.lastname: Latypova
authors.forename: I S
authors.initials: IS
authors.lastname: Berezkina
authors.forename: V V
authors.initials: VV
authors.lastname: Novitskii
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction; D014157:Transcription Factors; D014158:Transcription, Genetic; D051176:beta Catenin / Q000737:chemistry* / Q000235:genetics*
chemical_list: D014157:Transcription Factors; D051176:beta Catenin