title: Cardiomyocyte Ca2+ dynamics: clinical perspectives.
abstract: In the heart, Ca(2+) signals regulate a variety of biological functions ranging from contractility to gene expression, cellular hypertrophy and death. In this review, we summarize the role of local Ca(2+) homeostasis in these processes in healthy cardiac muscle cells, and highlight how mismanaged Ca(2+) handling contributes to the pathophysiology of conditions such as cardiac arrhythmia, ischemic heart disease, cardiac hypertrophy and heart failure. Aiming to provide an introduction to the field with a clinical perspective, we also indicate how current and future therapies may modulate cardiomyocytes Ca(2+) handling for the treatment of patients.
authors.affiliation: a Bjørknes College , Oslo , Norway ;
authors.forename: Jan Magnus
authors.initials: JM
authors.lastname: Aronsen
authors.affiliation: b Institute for Experimental Medical Research, Oslo University Hospital Ullevål and University of Oslo , Oslo , Norway.
authors.forename: William E
authors.initials: WE
authors.lastname: Louch
authors.affiliation: b Institute for Experimental Medical Research, Oslo University Hospital Ullevål and University of Oslo , Oslo , Norway.
authors.forename: Ivar
authors.initials: I
authors.lastname: Sjaastad
mesh_terms: D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000187:drug effects; D002317:Cardiovascular Agents / Q000627:therapeutic use; D056966:Excitation Contraction Coupling; D006331:Heart Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007700:Kinetics; D009200:Myocardial Contraction; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism*
chemical_list: D002317:Cardiovascular Agents; D002118:Calcium
keywords: Calcium; cardiomyocyte; pathophysiology