title: Dose-Response Analysis Using R.
abstract: Dose-response analysis can be carried out using multi-purpose commercial statistical software, but except for a few special cases the analysis easily becomes cumbersome as relevant, non-standard output requires manual programming. The extension package drc for the statistical environment R provides a flexible and versatile infrastructure for dose-response analyses in general. The present version of the package, reflecting extensions and modifications over the last decade, provides a user-friendly interface to specify the model assumptions about the dose-response relationship and comes with a number of extractors for summarizing fitted models and carrying out inference on derived parameters. The aim of the present paper is to provide an overview of state-of-the-art dose-response analysis, both in terms of general concepts that have evolved and matured over the years and by means of concrete examples.
authors.affiliation: Department of Nutrition, Exercise and Sports, University of Copenhagen, Rolighedsvej 26, DK-1958 Frederiksberg C, Denmark.
authors.forename: Christian
authors.initials: C
authors.lastname: Ritz
authors.affiliation: Pneumology, Kantonsspital St. Gallen, Rorschacher Strasse 95, CH-9007 St. Gallen, Switzerland.
authors.forename: Florent
authors.initials: F
authors.lastname: Baty
authors.affiliation: Department of Plant and Environmental Sciences, University of Copenhagen, Højbakkegård Allé 13, DK-2630 Taastrup, Denmark.
authors.forename: Jens C
authors.initials: JC
authors.lastname: Streibig
authors.affiliation: School of Mathematics and Statistics, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gerhard
mesh_terms: D000818:Animals; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016018:Least-Squares Analysis; D016013:Likelihood Functions; D015233:Models, Statistical; D017711:Nonlinear Dynamics; D012984:Software