title: Cbx4: A new guardian of p63's domain of epidermal control.
abstract: Epigenetic regulators are essential for cell lineage choices during development. In this issue, Mardaryev et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506065) show that Polycomb subunit Cbx4 acts downstream of transcriptional regulator p63 to maintain epidermal progenitor identity and proliferation in the developing epidermis via Polycomb-dependent and -independent SUMO E3 ligase activities.
authors.affiliation: Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
authors.forename: Idan
authors.initials: I
authors.lastname: Cohen
authors.affiliation: Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029 elena.ezhkova@mssm.edu.
authors.forename: Elena
authors.initials: E
authors.lastname: Ezhkova
mesh_terms: D000818:Animals; D019070:Cell Lineage; D004847:Epithelial Cells / Q000166:cytology* / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism*; D063150:Polycomb Repressive Complex 1 / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D063150:Polycomb Repressive Complex 1; D044767:Ubiquitin-Protein Ligases