title: Approach to the Solid Organ Transplant Patient with Suspected Fungal Infection.
abstract: In solid organ transplant (SOT) recipients, invasive fungal infections (IFIs) are associated with significant morbidity and mortality. Detection of IFIs can be difficult because the signs and symptoms are similar to those of viral or bacterial infections, and diagnostic techniques have limited sensitivity and specificity. Clinicians must rely on knowledge of the patient's risk factors for fungal infection to make a diagnosis. The authors describe their approach to the SOT recipient with suspected fungal infection. The epidemiology of IFIs in the SOT population is reviewed, and a syndromic approach to suspected IFI in SOT recipients is described.
authors.affiliation: Division of Infectious Diseases, University of Pennsylvania, 3400 Spruce Street, 3 Silverstein, Suite E, Philadelphia, PA 19104, USA.
authors.forename: Judith A
authors.initials: JA
authors.lastname: Anesi
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, 1900 University Boulevard, 229 THT, Birmingham, AL 35294, USA; Medical Service, Birmingham VA Medical Center, 700 South 19th street, Birmingham, AL 35233, USA. Electronic address: jbaddley@uab.edu.
authors.forename: John W
authors.initials: JW
authors.lastname: Baddley
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D009181:Mycoses / Q000175:diagnosis* / Q000276:immunology* / Q000382:microbiology; D016377:Organ Transplantation / Q000009:adverse effects*
chemical_list: D000935:Antifungal Agents
keywords: Aspergillus; Candida; Cryptococcus; Endemic fungi; Invasive fungal infection; Mold; Solid organ transplant