title: Evidence of anhedonia and differential reward processing in prefrontal cortex among post-withdrawal patients with prescription opiate dependence.
abstract: Anhedonia is an important but understudied element of a neuroadaptive model underlying vulnerability to relapse in opioid dependence. Previous research using fMRI has shown reduced activation to pleasant stimuli in rostral prefrontal cortex among heroin-dependent patients in early recovery. This study evaluated the presence of anhedonia among recently withdrawn prescription opiate dependent patients (PODP) in residential treatment compared to control subjects. Anhedonia was assessed using self-report, affect-modulated startle response (AMSR), and a cue reactivity task during which participant's rostral prefrontal cortex (RPFC) and ventrolateral prefrontal cortex (VLPFC) was monitored with functional near infrared spectroscopy (fNIRS). The cue reactivity task included three distinct categories of natural reward stimuli: highly palatable food, positive social situations, and intimate (non-erotic) interactions. PODP reported greater anhedonia on self-report (Snaith-Hamilton Pleasure Scale), and showed reduced hedonic response to positive stimuli in the AMSR task relative to controls. PODP also exhibited reduced neural activation in bilateral RPFC and left VLPFC in response to food images and reduced left VLPFC in response to images depicting positive social situations relative to controls. No differences were found for emotionally intimate stimuli. When patients were divided into groups based on the Snaith-Hamilton criteria for the presence or absence of anhedonia, patients endorsing anhedonia showed reduced neural responses to images depicting positive social stimuli and food relative to patients who did not endorse anhedonia. Activations were in areas of RPFC that support the retrieval of episodic memories. The results suggest the presence of anhedonia in a subsample of PODP.
authors.affiliation: Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA, United States.
authors.forename: A S
authors.initials: AS
authors.lastname: Huhn
authors.affiliation: Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA, United States.
authors.forename: R E
authors.initials: RE
authors.lastname: Meyer
authors.affiliation: Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA, United States.
authors.forename: J D
authors.initials: JD
authors.lastname: Harris
authors.affiliation: School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United States.
authors.forename: H
authors.initials: H
authors.lastname: Ayaz
authors.affiliation: Caron Treatment Centers, Wernersville, PA, United States.
authors.forename: E
authors.initials: E
authors.lastname: Deneke
authors.affiliation: Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA, United States.
authors.forename: D M
authors.initials: DM
authors.lastname: Stankoski
authors.affiliation: Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA, United States; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United States. Electronic address: sbunce@hmc.psu.edu.
authors.forename: S C
authors.initials: SC
authors.lastname: Bunce
mesh_terms: D000328:Adult; D059445:Anhedonia / Q000187:drug effects* / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D016022:Case-Control Studies; D003463:Cues; D004644:Emotions / Q000187:drug effects; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009293:Opioid-Related Disorders / Q000150:complications / Q000378:metabolism / Q000523:psychology*; D017397:Prefrontal Cortex / Q000502:physiology; D012201:Reward; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013375:Substance Withdrawal Syndrome / Q000378:metabolism
keywords: Affect modulated startle response; Anhedonia; Cue reactivity; Functional near-infrared spectroscopy; Lack of pleasure; Prescription opioids