title: [Pathogenesis of atypical femoral fracture].
abstract: We demonstrated microdamage accumulation in the fracture sites in the patients of subtrochanteric atypical femoral fracture with long term bisphosphonate therapy and of incomplete shaft fracture of lateral femoral bowing without bisphosphonate therapy. Based on these findings, pathogenesis of atypical femoral fracture is revealed stress fracture caused by accumulation of microdamages between distal to the lesser trochanter and proximal to the supracondylar flare in the femur in association with severely suppressed bone turnover and/or abnormal lower limb alignment, that causes stress concentration on the lateral side cortex of the femur.
authors.affiliation: Department of Orthopedic Surgery, Kagawa University Faculty of Medicine, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Iwata
authors.affiliation: Department of Orthopedic Surgery, Kagawa University Faculty of Medicine, Japan.
authors.forename: Tasuku
authors.initials: T
authors.lastname: Mashiba
mesh_terms: D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D004164:Diphosphonates / Q000009:adverse effects*; D005264:Femoral Fractures / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology*; D005269:Femur / Q000378:metabolism / Q000473:pathology; D015775:Fractures, Stress / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology*; D006801:Humans
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates