title: Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications.
abstract: Biometal systems have been widely used for biomedical applications, in particular, as load-bearing materials. However, major challenges are high stiffness and low bioactivity of metals. In this study, we have developed a new method towards fabricating a new type of bioactive and mechanically reliable porous metal scaffolds-densified porous Ti scaffolds. The method consists of two fabrication processes, 1) the fabrication of porous Ti scaffolds by dynamic freeze casting, and 2) coating and densification of the porous scaffolds. The dynamic freeze casting method to fabricate porous Ti scaffolds allowed the densification of porous scaffolds by minimizing the chemical contamination and structural defects. The densification process is distinctive for three reasons. First, the densification process is simple, because it requires a control of only one parameter (degree of densification). Second, it is effective, as it achieves mechanical enhancement and sustainable release of biomolecules from porous scaffolds. Third, it has broad applications, as it is also applicable to the fabrication of functionally graded porous scaffolds by spatially varied strain during densification.
authors.affiliation: Liquid Processing & Casting Technology R&D Group, Korea Institute of Industrial Technology.
authors.forename: Hyun-Do
authors.initials: HD
authors.lastname: Jung
authors.affiliation: Department of Materials Science and Engineering, Seoul National University.
authors.forename: Hyun
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Materials Science and Engineering, Seoul National University; Advanced Institutes of Convergence Technology, Seoul National University.
authors.forename: Hyoun-Ee
authors.initials: HE
authors.lastname: Kim
authors.affiliation: School of Biomedical Engineering, Korea University.
authors.forename: Young-Hag
authors.initials: YH
authors.lastname: Koh
authors.affiliation: Advanced Institutes of Convergence Technology, Seoul National University; sat105@snu.ac.kr.
authors.forename: Juha
authors.initials: J
authors.lastname: Song
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D005615:Freezing; D016062:Porosity; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods*; D054457:Tissue Scaffolds; D014025:Titanium / Q000737:chemistry*; D016474:Weight-Bearing
chemical_list: D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D014025:Titanium