title: Standard Operating Procedures (SOPs) for Evaluating the Heart in Preclinical Studies of Duchenne Muscular Dystrophy.
abstract: A recent working group meeting focused on contemporary cardiac issues in Duchenne muscular dystrophy (DMD) was hosted by the National Heart, Lung, and Blood Institute in collaboration with the Parent Project Muscular Dystrophy. An outcome of this meeting was to provide freely available detailed protocols for preclinical animal studies. The goal of these protocols is to improve the quality and reproducibility of cardiac preclinical studies aimed at developing new therapeutics for the prevention and treatment of DMD cardiomyopathy.
authors.affiliation: Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO, USA.|Department of Neurology, School of Medicine, University of Missouri, Columbia, MO, USA.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Duan
authors.affiliation: Departments of Physiology & Cell Biology and Molecular & Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, OH, USA.
authors.forename: Jill A
authors.initials: JA
authors.lastname: Rafael-Fortney
authors.affiliation: Institute of Genetic Medicine, Newcastle University, Newcastle, UK.
authors.forename: Alison
authors.initials: A
authors.lastname: Blain
authors.affiliation: The Johns Hopkins University Medical Institutions, Baltimore, MD, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Kass
authors.affiliation: Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: McNally
authors.affiliation: Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Metzger
authors.affiliation: Division of Cardiology and Center for Genetic Medicine Research, Children's National Heart Institute, Children's National Health System, Washington, DC, USA.
authors.forename: Christopher F
authors.initials: CF
authors.lastname: Spurney
authors.affiliation: Parent Project Muscular Dystrophy, Middletown, OH, USA. kathi@parentprojectmd.org.
authors.forename: Kathi
authors.initials: K
authors.lastname: Kinnett
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000592:standards; D032921:Consensus; D003245:Consensus Statements as Topic; D004195:Disease Models, Animal; D006321:Heart / Q000503:physiopathology; D020388:Muscular Dystrophy, Duchenne / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D009206:Myocardium / Q000473:pathology; D015203:Reproducibility of Results; D017410:Practice Guidelines as Topic
keywords: Cardiology; Cardiomyopathy; Duchenne; Preclinical; Standard operating procedures (SOPs)