title: Altered intrinsic regional spontaneous brain activity in patients with optic neuritis: a resting-state functional magnetic resonance imaging study.
abstract: OBJECTIVE
  To investigate the underlying regional homogeneity (ReHo) in brain-activity deficit in patients with optic neuritis (ON) and its relationship with behavioral performance.
  
  
  METHODS
  In total, twelve patients with ON (four males and eight females) and twelve (four males and eight females) age-, sex-, and education-matched healthy controls underwent resting-state functional magnetic resonance imaging scans. The ReHo method was used to assess the local features of spontaneous brain activity. Correlation analysis was used to explore the relationship between the observed mean ReHo values of the different brain areas and the visual evoked potential (VEP) in patients with ON.
  
  
  RESULTS
  Compared with the healthy controls, patients with ON showed lower ReHo in the left cerebellum, posterior lobe, left middle temporal gyrus, right insula, right superior temporal gyrus, left middle frontal gyrus, bilateral anterior cingulate cortex, left superior frontal gyrus, right superior frontal gyrus, and right precentral gyrus, and higher ReHo in the cluster of the left fusiform gyrus and right inferior parietal lobule. Meanwhile, we found that the VEP amplitude of the right eye in patients with ON showed a positive correlation with the ReHo signal value of the left cerebellum posterior lobe (r=0.701, P=0.011), the right superior frontal gyrus (r=0.731, P=0.007), and the left fusiform gyrus (r=0.644, P=0.024). We also found that the VEP latency of the right eye in ON showed a positive correlation with the ReHo signal value of the right insula (r=0.595, P=0.041).
  
  
  CONCLUSIONS
  ON may involve dysfunction in the default-mode network, which may reflect the underlying pathologic mechanism.
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Department of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Feng-Qin
authors.initials: FQ
authors.lastname: Cai
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Zhong
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China ; Department of Ophthalmology, First People's Hospital of Jiujiang, Jiujiang, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Pei-Hong
authors.initials: PH
authors.lastname: Hu
authors.affiliation: Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Chong-Gang
authors.initials: CG
authors.lastname: Pei
authors.affiliation: Department of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Fu-Qing
authors.initials: FQ
authors.lastname: Zhou
authors.affiliation: Department of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Xian-Jun
authors.initials: XJ
authors.lastname: Zeng
keywords: optic neuritis; regional homogeneity; rs-fMRI; visual evoked potential