title: LncRNAs: key players and novel insights into cervical cancer.
abstract: Cervical cancer contributed the second highest number of deaths in female cancers, exceeded only by breast cancer, carrying high risks of morbidity and mortality. There was a great need and urgency in searching novel treatment targets and prognosis biomarkers to improve the survival rate of cervical cancer patients. Many long non-coding RNAs (lncRNAs) were emerging as pivotal regulators in various biological processes and took vitally an effect on the oncogenesis and progression of cervical cancer. In this review, we summarized the origin and overview function of lncRNAs; highlighted the roles of lncRNAs in cervical cancer in terms of prognosis and tumor progression, invasion and metastasis, apoptosis, and radio-resistance; and outlined the molecular mechanisms of lncRNAs in cervical cancer from the aspects of the interaction of lncRNAs with proteins/mRNAs (especially in HPV protein) and miRNAs, as well as RNA N-methyladenosine (m6A) methylation of lncRNAs. Meanwhile, the application of lncRNAs as biomarkers in cervical cancer prognosis and predictors for metastasis was also discussed. An overview of these researches will be valuable for broadening horizons into mechanisms, selection of meritorious biomarkers for diagnosis as well as prognosis, and future targeted therapy of cervical cancer.
authors.affiliation: Cancer Research Institute, Central South University, Changsha, 410078, China.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha, 410078, China.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, 410078, China.
authors.forename: Li
authors.initials: L
authors.lastname: Peng
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.|Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Cancer Research Institute, Central South University, Changsha, 410078, China.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha, 410078, China.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, 410078, China.
authors.forename: Binyuan
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Department of Medical Record Management and Statistics, the First Affiliated Hospital, University of South China, Hengyang, 421002, China.
authors.forename: Zaili
authors.initials: Z
authors.lastname: Tang
authors.affiliation: Cancer Research Institute, Central South University, Changsha, 410078, China. libsun@163.com.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha, 410078, China. libsun@163.com.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha, 410078, China. libsun@163.com.
authors.forename: Guan-Cheng
authors.initials: GC
authors.lastname: Li
mesh_terms: D017209:Apoptosis; D049109:Cell Proliferation; D018450:Disease Progression; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D062085:RNA, Long Noncoding / Q000502:physiology*; D011836:Radiation Tolerance; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology*
chemical_list: D062085:RNA, Long Noncoding
keywords: Cervical cancer; Dysregulation; EMT; EZH2; Function; GAS5; HOTAIR; LncRNA; LncRNA-ANRIL; LncRNA-CCHE1; LncRNA-EBIC; LncRNA-LET; MALAT1; MEG3; Mechanism; NEAT2; TUSC8; Xist; ceRNA; m6A