title: Sugar and Glycerol Transport in Saccharomyces cerevisiae.
abstract: In Saccharomyces cerevisiae the process of transport of sugar substrates into the cell comprises a complex network of transporters and interacting regulatory mechanisms. Members of the large family of hexose (HXT) transporters display uptake efficiencies consistent with their environmental expression and play physiological roles in addition to feeding the glycolytic pathway. Multiple glucose-inducing and glucose-independent mechanisms serve to regulate expression of the sugar transporters in yeast assuring that expression levels and transporter activity are coordinated with cellular metabolism and energy needs. The expression of sugar transport activity is modulated by other nutritional and environmental factors that may override glucose-generated signals. Transporter expression and activity is regulated transcriptionally, post-transcriptionally and post-translationally. Recent studies have expanded upon this suite of regulatory mechanisms to include transcriptional expression fine tuning mediated by antisense RNA and prion-based regulation of transcription. Much remains to be learned about cell biology from the continued analysis of this dynamic process of substrate acquisition.
authors.affiliation: Department of Viticulture and Enology, University of California, Davis, CA, 95616, USA. lfbisson@ucdavis.edu.
authors.forename: Linda F
authors.initials: LF
authors.lastname: Bisson
authors.affiliation: Department of Viticulture and Enology, University of California, Davis, CA, 95616, USA.
authors.forename: Qingwen
authors.initials: Q
authors.lastname: Fan
authors.affiliation: Department of Viticulture and Enology, University of California, Davis, CA, 95616, USA.
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Walker
mesh_terms: D001692:Biological Transport; D015966:Gene Expression Regulation, Fungal; D005990:Glycerol / Q000737:chemistry / Q000378:metabolism*; D006601:Hexoses / Q000737:chemistry / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011328:Prions / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis; D016372:RNA, Antisense / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D006601:Hexoses; D026901:Membrane Transport Proteins; D011328:Prions; D016372:RNA, Antisense; D029701:Saccharomyces cerevisiae Proteins; D005990:Glycerol
keywords: HXT; PMA1; Post-translational modification; Prion; Stress