title: A Hemophagocytic Lymphohistiocytosis Patient that Presented with Unilateral Panuveitis.
abstract: OBJECTIVE
  To describe a case of hemophagocytic lymphohistiocytosis (HLH) with ocular changes prior to the systemic changes.
  
  
  METHODS
  A 53-year-old man presented with the chief complaint of decreased vision in his right eye. The patient was examined by ocular examination, slit lamp examination, optical coherence tomography, laboratory examination, abdominal ultrasound, and bone marrow biopsy.
  
  
  RESULTS
  Ocular examination revealed uveitis OD and optical coherence tomography revealed macular edema OD. Laboratory examination demonstrated cytopenia in two cell lines, hypofibrinogenemia, and elevated serum ferritin. Abdominal ultrasound findings indicated hepatosplenomegaly. The bone marrow biopsy specimen demonstrated histiocytes and significant hemophagocytosis, leading to a diagnosis of HLH.
  
  
  CONCLUSIONS
  Ophthalmic manifestation can be the first sign of HLH and progress to fatal systemic changes.
authors.affiliation: a Department of Intensive Care Unit, the First Affiliated Hospital , China Medical University , Liaoning , China.
authors.forename: Xu
authors.initials: X
authors.lastname: Li
authors.affiliation: b Department of Intensive Care Unit , General Hospital of Panjin Oilfield , Panjin , Liaoning , China.
authors.forename: Yanquan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: a Department of Intensive Care Unit, the First Affiliated Hospital , China Medical University , Liaoning , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tang
authors.affiliation: a Department of Intensive Care Unit, the First Affiliated Hospital , China Medical University , Liaoning , China.
authors.forename: Tianlu
authors.initials: T
authors.lastname: Chen
authors.affiliation: a Department of Intensive Care Unit, the First Affiliated Hospital , China Medical University , Liaoning , China.
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Ma
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D006529:Hepatomegaly / Q000175:diagnosis; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000188:drug therapy; D008269:Macular Edema / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D000077731:Meropenem; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D015864:Panuveitis / Q000175:diagnosis* / Q000188:drug therapy; D000072776:Slit Lamp Microscopy; D013163:Splenomegaly / Q000175:diagnosis; D013845:Thienamycins / Q000627:therapeutic use; D041623:Tomography, Optical Coherence
chemical_list: D000900:Anti-Bacterial Agents; D016756:Immunoglobulins, Intravenous; D013845:Thienamycins; D000077731:Meropenem; D008775:Methylprednisolone
keywords: hemophagocytic lymphohistiocytosis; multiple organ dysfunction syndrome; retina; uveitis