title: Selenium supplementation restores the decreased albumin level of peripheral blood mononuclear cells in streptozotocin-induced diabetic mice.
abstract: Previously, it has been suggested that the phenotypic level of albumin in peripheral blood mononuclear cells (PBMC) decreased in streptozotocin (STZ)-induced diabetic rats. Concomitantly, the production of oxidative stresses was also elevated in the diabetic PBMC compared to that of normal control. These results suggest the close relationship between PBMC-albumin and its antioxidant roles. Here, we expanded the previous studies and investigated the effect of selenium supplementation as inorganic (sodium selenate) forms on the levels of albumin expression and oxidative stress in PBMC of STZ-induced diabetic mice. Selenium intake recovered the decreased albumin levels to those of normal mice and reduced the production of reactive oxygen species (ROS). These results support that selenium intake may alleviate the etiology and pathology of PBMC in type 1 diabetic mice by restoring the decrease in albumin contents and the production of ROS.
authors.affiliation: College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of Korea.
authors.forename: Taeho
authors.initials: T
authors.lastname: Ahn
authors.forename: Chun-Sik
authors.initials: CS
authors.lastname: Bae
authors.forename: Chul-Ho
authors.initials: CH
authors.lastname: Yun
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000178:diet therapy*; D019587:Dietary Supplements; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D017382:Reactive Oxygen Species / Q000097:blood; D064586:Selenic Acid / Q000627:therapeutic use*; D012643:Selenium / Q000627:therapeutic use; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species; D012709:Serum Albumin; D012643:Selenium; D064586:Selenic Acid