title: A facile green approach to prepare core-shell hybrid PLGA nanoparticles for resveratrol delivery.
abstract: Green approach has revolutionized the area of nanoparticles (NPs) synthesis by virtue of eco and health friendly protocols. Advancing this further, the study proposes a captivating solvent free method for the preparation of green PLGA-oil nanohybrids (G-PONHs) using acrysol oil and encapsulation of resveratrol therein. G-PONHs were structurally similar to the standard PONHs, but had larger particle size of 375 nm. Avoidance of organic solvents resulted in the formation of smooth NPs which showed a considerable improvement in drug release profile and antioxidant properties. G-PONHs exhibited superior biocompatibility with normal Vero cells, while the cytotoxicity on breast cancer cells was moderate in comparison to standard NPs owing to their large size. The size of NPs was found to be a critical factor governing the amplitude of cytotoxicity. The comparative high stability of G-PONHs further favors the tremendous potential of this novel preparation method and delivery platform.
authors.affiliation: Department of Pharmaceutics, JCDM College of Pharmacy, Sirsa, 125055, India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Pharmaceutical Chemistry, JCDM College of Pharmacy, Sirsa, 125055, India.
authors.forename: Viney
authors.initials: V
authors.lastname: Lather
authors.affiliation: Department of Pharmaceutics, JCDM College of Pharmacy, Sirsa, 125055, India. Electronic address: deeptipandita@yahoo.co.uk.
authors.forename: Deepti
authors.initials: D
authors.lastname: Pandita
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D000077185:Resveratrol; D017550:Spectroscopy, Fourier Transform Infrared; D013267:Stilbenes / Q000008:administration & dosage*; D014709:Vero Cells
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D004337:Drug Carriers; D013267:Stilbenes; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D000077185:Resveratrol
keywords: Nanocomposites; Polymer-oil; Solvent-free