title: LDH-A promotes malignant progression via activation of epithelial-to-mesenchymal transition and conferring stemness in muscle-invasive bladder cancer.
abstract: Lactate dehydrogenase-A(LDH-A) is an important rate-limiting enzyme in the Warburg effect. Survival analysis indicated poor clinical outcomes in MIBC with high LDH-A expression. The results of in vitro experiment indicated that LDH-A promotes MIBC cells proliferation, invasion and migration. The positive relationship between LDH-A expression and CSC/EMT markers was confirmed both in invasive bladder cell line and in 136 MIBC specimens. Thus, we conclude that LDH-A may be a promising target for MIBC.
authors.affiliation: Department of Urinary Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Department of Urinary Surgery, Huai'an Hospital to Xuzhou Medical University, Huai'an, Jiangsu, China.
authors.forename: Fujin
authors.initials: F
authors.lastname: Jiang
authors.affiliation: Department of Urinary Surgery, Huai'an Hospital to Xuzhou Medical University, Huai'an, Jiangsu, China.
authors.forename: Song
authors.initials: S
authors.lastname: Ma
authors.affiliation: Department of Medical Oncology, Huai'an Hospital to Xuzhou Medical University, Huai'an, Jiangsu, China.
authors.forename: Yubao
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Department of Urinary Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address: Jianquanhou@aliyun.com.
authors.forename: Jianquan
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of Medical Oncology, Huai'an Hospital to Xuzhou Medical University, Huai'an, Jiangsu, China. Electronic address: zhangyj0818@126.com.
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D063646:Carcinogenesis / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D002681:China / Q000453:epidemiology; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D000080864:Lactate Dehydrogenase 5; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000201:enzymology / Q000473:pathology; D009361:Neoplasm Invasiveness; D014411:Neoplastic Stem Cells / Q000201:enzymology / Q000473:pathology*; D015995:Prevalence; D016019:Survival Analysis; D001749:Urinary Bladder Neoplasms / Q000201:enzymology* / Q000401:mortality* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D000080864:Lactate Dehydrogenase 5
keywords: E-cadherin; Epithelial-to-mesenchymal transition; Histone deacetylases; Lactate dehydrogenase-A; Muscle-invasive bladder cancer; Oct4