title: The Synthesis of the Metabolites of 2',3',5'-Tri-O-acetyl-N₆-(3-hydroxyphenyl) Adenosine (WS070117).
abstract: Seven metabolites of 2',3',5'-tri-O-acetyl-N₆-(3-hydroxyphenyl) adenosine (WS070117) were synthesized by deacetylation, hydrolysis, cyclization, sulfonylation and glycosylation reactions, respectively. All these compounds, which could be useful as material standards for metabolic research, were characterized by NMR and HPLC-MS (ESI) analyses.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. wxzhang@imm.ac.cn.
authors.forename: Wen-Xuan
authors.initials: WX
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. hongnawu@imm.ac.cn.
authors.forename: Hong-Na
authors.initials: HN
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. bolee@imm.ac.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. redwoods86@sina.com.
authors.forename: Hong-Lin
authors.initials: HL
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. wangdmchina@imm.ac.cn.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. ws@imm.ac.cn.
authors.forename: Song
authors.initials: S
authors.lastname: Wu
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry; D003500:Cyclization; D006031:Glycosylation; D006868:Hydrolysis; D015394:Molecular Structure
chemical_list: C561084:O2',O3',O5'-triacetyl-N6-(3-hydroxylaniline)adenosine; D000241:Adenosine
keywords: WS070117; metabolites; synthesis