title: Optogenetic control of thalamus as a tool for interrupting penicillin induced seizures.
abstract: Penicillin epilepsy model, whose discharge resembles that of human absence epilepsy, is one of the most useful acute experimental epilepsy models. Though closed-loop optogenetic strategy of interrupting seizures was proved sufficient to switch off epilepsy by controlling thalamus in the post-lesion partial chronic epilepsy model, doubts still exist in absence epilepsy attenuation through silencing thalamus. Here we directly arrested the thalamus to modulate penicillin-induced absence seizures through pseudorandom responsive stimulation on eNpHR-transfected rats. Our data suggested that the duration of epileptiform bursts under light conditions, compared with no light conditions, did not increase or decrease when modulated specific eNpHR-expressing neurons in thalamus.
authors.forename: Yechao
authors.initials: Y
authors.lastname: Han
authors.forename: Feiqiang
authors.initials: F
authors.lastname: Ma
authors.forename: Hongbao
authors.initials: H
authors.lastname: Li
authors.forename: Yueming
authors.initials: Y
authors.lastname: Wang
authors.forename: Kedi
authors.initials: K
authors.lastname: Xu
mesh_terms: D000818:Animals; D004832:Epilepsy, Absence / Q000139:chemically induced* / Q000235:genetics / Q000628:therapy; D025602:Halorhodopsins / Q000235:genetics*; D008297:Male; D009474:Neurons / Q000378:metabolism*; D062308:Optogenetics; D010406:Penicillins / Q000009:adverse effects*; D051381:Rats; D013788:Thalamus / Q000378:metabolism*; D019076:Transgenes
chemical_list: D025602:Halorhodopsins; D010406:Penicillins