title: Putative hormone with anti-obesogenic and insulin-sensitizing effect.
abstract: It was confirmed that bone morphogenetic protein-9 (BMP-9), like insulin, improves glycemia in diabetic mice and regulates glucose metabolism in hepatocytes, which is why it is proposed as a candidate for the hepatic insulin-sensitizing substance (HISS). Regarding the fact that BMP-9 has a signaling pathway similar to other BMPs as well as insulin, it is expected that BMP-9 would also have certain effects on the liver. In our 2011 hypothesis, we aimed towards BMP-9 as a possible "hepatic insulin-sensitizing substance" (HISS) and in this article, we provide further evidence, derived from existing studies, suggesting that this putative hormone might in fact be none other than BMP-9.
authors.affiliation: Clinical Hospital Center Rijeka, Rijeka, Croatia ivan.sosa@medri.uniri.hr.
authors.forename: Ivan
authors.initials: I
authors.lastname: Sosa
authors.affiliation: Department of Internal Medicine, Clinical Hospital Center Rijeka, Rijeka, Croatia.
authors.forename: Aron
authors.initials: A
authors.lastname: Grubesic
mesh_terms: D005943:Gluconeogenesis / Q000187:drug effects; D055427:Growth Differentiation Factor 2 / Q000494:pharmacology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D009569:Nitric Oxide / Q000502:physiology
chemical_list: D055427:Growth Differentiation Factor 2; D007004:Hypoglycemic Agents; D007328:Insulin; D009569:Nitric Oxide
keywords: BMP-9; NO; endothelium