title: Endothelial Dysfunction in Renal Failure: Current Update.
abstract: Endothelial dysfunction is principally characterized by impaired endothelium- dependent transduction mechanisms related to vascular relaxation, as an outcome of decreased release of endothelium-derived relaxing factors, mainly nitric oxide, as well as augmented oxidative stress, increased inflammation and predominance of vascular action produced by endothelium-derived contracting factors. Current data strongly suggest that pathological development of different types of kidney impairment with further progression to renal failure includes notable vascular changes associated with endothelial dysfunction. In accordance, this scientific field represents an advancing area of investigation, involving different biomarkers of endothelial dysfunction linked to renal impairment, as well as clinical findings with new information that can provide a more comprehensive understanding of the role of endothelial dysfunction in kidney disease. With regards to quoted facts, the aim of this article was to review the latest data related to endothelial dysfunction and renal failure by selection of relevant articles released from 2010 to 2015.
authors.affiliation: Department of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, PO Box 38, 11129 Belgrade, Serbia. mradenkovic@med.bg.ac.rs.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Radenkovic
authors.forename: Marko
authors.initials: M
authors.lastname: Stojanovic
authors.forename: Milica
authors.initials: M
authors.lastname: Prostran
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D051437:Renal Insufficiency / Q000150:complications / Q000473:pathology* / Q000628:therapy; D014511:Uremia / Q000150:complications; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism; D014808:Vitamin D Deficiency / Q000150:complications
chemical_list: D019010:Vascular Cell Adhesion Molecule-1; D009569:Nitric Oxide; C024917:symmetric dimethylarginine; C018524:N,N-dimethylarginine; D001120:Arginine