title: Design, synthesis and in vivo screening of some novel quinazoline analogs as anti-hyperlipidemic and hypoglycemic agents.
abstract: A novel series of substituted quinazoline derivatives were designed, synthesized and evaluated for their hypolipidemic activity in cholesterol induced hyperlipidemic rats. In vivo screening concluded that compounds A-4, C-5 and C-6 have shown potent antihyperlipidemic activity by decreasing the plasma level of triglycerides (TG), very low density lipoprotein (VLDL), low density lipoprotein (LDL), followed by increase in level of high density lipoprotein (HDL).
authors.affiliation: Dr. Rafiq Zakaria Campus, Y. B. Chavan College of Pharmacy, Aurangabad 431001, Maharashtra, India.
authors.forename: Santosh N
authors.initials: SN
authors.lastname: Mokale
authors.affiliation: Dr. Rafiq Zakaria Campus, Y. B. Chavan College of Pharmacy, Aurangabad 431001, Maharashtra, India.
authors.forename: Akash D
authors.initials: AD
authors.lastname: Palkar
authors.affiliation: Dr. Rafiq Zakaria Campus, Y. B. Chavan College of Pharmacy, Aurangabad 431001, Maharashtra, India.
authors.forename: Pritam N
authors.initials: PN
authors.lastname: Dube
authors.affiliation: Dr. Rafiq Zakaria Campus, Y. B. Chavan College of Pharmacy, Aurangabad 431001, Maharashtra, India.
authors.forename: Nikhil S
authors.initials: NS
authors.lastname: Sakle
authors.affiliation: Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmacy, Narhe, Pune, Maharashtra, India.
authors.forename: Pankaj B
authors.initials: PB
authors.lastname: Miniyar
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D011345:Fenofibrate / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D008074:Lipoproteins / Q000378:metabolism; D011799:Quinazolines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000378:metabolism
chemical_list: D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008074:Lipoproteins; D011799:Quinazolines; D014280:Triglycerides; D002784:Cholesterol; D011345:Fenofibrate
keywords: Antihyperlipidemic; Hypoglycemic; Quinazoline