title: Effect of Taurine on Hemodiafiltration in Patients With Chronic Heart Failure.
abstract: Taurine, an important factor in the living body, is essential for cardiovascular function and development and function of skeletal muscle, retina and central nervous system. In the present study, its effect on cardiovascular function was specifically taken into consideration. In hemodiafiltration (HDF) patients, the effect of taurine on patients with chronic heart failure (CHF), in whom dry weight was difficult to control, was evaluated. All patients who were subjected to regular HDF for 4 h three times per week at Joban hospital were included in this study. Patients with chronic heart failure, in whom dry weight was difficult to control (N = 4), were included in the evaluation of clinical status. X-ray and echocardiography were determined before and after taurine treatment. Almost all patients were taking nitric acid, warfarin, anti-platelet agents and vasopressors. Because vital signs were unstable in chronic heart failure, all cases withheld antihypertensive drugs during HDF. For unstable vital signs during HDF, pulmonary congestion was chronically recognized. After taurine was started, vital signs stabilized and lowering of dry weight was possible. In addition, X-ray and cardiac diastolic failure on echocardiography improved. Taurine was effective for CHF patients on HDF in whom dry weight was difficult to control in spite of various medications.
authors.affiliation: Department of Medicine IV, Tokyo Women's Medical University, Tokyo, Japan.|Department of Blood Purification, Joban Hospital, Fukushima, Japan.
authors.forename: Shunji
authors.initials: S
authors.lastname: Shiohira
authors.affiliation: Department of Blood Purification, Joban Hospital, Fukushima, Japan.
authors.forename: Mizuki
authors.initials: M
authors.lastname: Komatsu
authors.affiliation: Department of Blood Purification, Joban Hospital, Fukushima, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Okazaki
authors.affiliation: Department of Blood Purification, Joban Hospital, Fukushima, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Naganuma
authors.affiliation: Department of Blood Purification, Joban Hospital, Fukushima, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
authors.affiliation: Department of Medicine IV, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Kosaku
authors.initials: K
authors.lastname: Nitta
authors.affiliation: Department of Medicine IV, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Tsuchiya
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000378:metabolism; D002908:Chronic Disease; D016903:Drug Monitoring / Q000379:methods; D004452:Echocardiography / Q000379:methods; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D008297:Male; D013654:Taurine / Q000008:administration & dosage / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents; D013654:Taurine
keywords: Chronic heart failure; Hemodiafiltration; Taurine