title: Neutron study of phospholipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-ethanolamine spray coating on titanium implants.
abstract: Permanent implants made from titanium are widely used and successfully implemented in medicine to address problems related to orthopedic and oral disorders. However, implants that interact in all cases optimally and durably with bone tissue have yet to be developed. Here, the authors suggest a phospholipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-ethanolamine (POPE) lipid coating to partially mimic the biological cell membrane. To improve the homogeneity of the POPE distribution on the metal surface, the lipids are applied by spray coating. It is shown that the spray coating leads to two types of multilamellar POPE structures. Our experimental results demonstrate that these coatings are stable in a liquid environment in the range of physiological temperatures due to the unique interbilayer interaction of POPE lipids. Additionally, the interaction of the POPE multilayer structure with human serum albumin is considered. A simultaneous analysis of the specular and off-specular data provides structural information necessary to assess the quality of the coating for future applications.
authors.affiliation: Institute of Structural Biology, University Joseph Fourier, 71 Avenue des Martyrs, 38000 Grenoble, France.
authors.forename: Maksym
authors.initials: M
authors.lastname: Golub
authors.affiliation: Institute of Materials Research, Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung (HZG), Max Plank str. 1, 21502 Geesthacht, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Lott
authors.affiliation: Institute of Materials Research, Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung (HZG), Max Plank str. 1, 21502 Geesthacht, Germany.
authors.forename: Vasil M
authors.initials: VM
authors.lastname: Garamus
authors.affiliation: Institute of Materials Research, Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung (HZG), Max Plank str. 1, 21502 Geesthacht, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Laipple
authors.affiliation: Institute of Materials Research, Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung (HZG), Max Plank str. 1, 21502 Geesthacht, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Stoermer
authors.affiliation: Materials Synthesis & Integrated Devices Group (MPA-11), Materials Physics and Applications Division, Los Alamos National Laboratory, P.O. Box 1663, Mail Stop K763, Los Alamos, New Mexico 87545.
authors.forename: Erik B
authors.initials: EB
authors.lastname: Watkins
authors.affiliation: Institute of Materials Research, Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung (HZG), Max Plank str. 1, 21502 Geesthacht, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Schreyer
authors.affiliation: Institute of Materials Research, Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung (HZG), Max Plank str. 1, 21502 Geesthacht, Germany.
authors.forename: Regine
authors.initials: R
authors.lastname: Willumeit-Römer
mesh_terms: D000336:Aerosols; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D006801:Humans; D033363:Neutron Diffraction / Q000379:methods*; D010714:Phosphatidylethanolamines / Q000032:analysis*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D013499:Surface Properties; D013696:Temperature; D014025:Titanium
chemical_list: D000336:Aerosols; D020099:Coated Materials, Biocompatible; D010714:Phosphatidylethanolamines; D012709:Serum Albumin; D014025:Titanium; C000608529:1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine