title: Association between resistin levels and cardiovascular disease events in older adults: The health, aging and body composition study.
abstract: OBJECTIVE
  Prospective data on the association between resistin levels and cardiovascular disease (CVD) events are sparse with conflicting results.
  
  
  METHODS
  We studied 3044 aged 70-79 years from the Health, Aging, and Body Composition Study. CVD events were defined as coronary heart disease (CHD) or stroke events. «Hard » CHD events were defined as CHD death or myocardial infarction. We estimated hazard ratio (HR) and 95% confidence intervals (CI) according to the quartiles of serum resistin concentrations and adjusted for clinical variables, and then further adjusted for metabolic disease (body mass index, fasting plasma glucose, abdominal visceral and subcutaneous adipose tissue, leptin, adiponectin, insulin) and inflammation (C-reactive protein, interleukin-6, tumor necrosis factors-α).
  
  
  RESULTS
  During a median follow-up of 10.1 years, 559 patients had « hard » CHD events, 884 CHD events and 1106 CVD Events. Unadjusted incidence rate for CVD events was 36.6 (95% CI 32.1-41.1) per 1000 persons-year in the lowest quartile and 54.0 per 1000 persons-year in the highest quartile (95% CI 48.2-59.8, P for trend < 0.001). In the multivariate models adjusted for clinical variables, HRs for the highest vs. lowest quartile of resistin was 1.52 (95% CI 1.20-1.93, P < 0.001) for « Hard » CHD events, 1.41 (95% CI 1.16-1.70, P = 0.001) for CHD events and 1.35 (95% CI 1.14-1.59, P = 0.002) for CVD events. Further adjustment for metabolic disease slightly reduced the associations while adjustment for inflammation markedly reduced the associations.
  
  
  CONCLUSIONS
  In older adults, higher resistin levels are associated with CVD events independently of clinical risk factors and metabolic disease markers, but markedly attenuated by inflammation.
authors.affiliation: Cardiology Division, Department of Medicine, Geneva University Hospital, Switzerland.
authors.forename: Baris
authors.initials: B
authors.lastname: Gencer
authors.affiliation: Department of Ambulatory and Community Medicine, Lausanne University Hospital, Switzerland.
authors.forename: Reto
authors.initials: R
authors.lastname: Auer
authors.affiliation: Geriatric Section, Department of Internal Medicine, Yale University, New Haven, CT, USA.
authors.forename: Nathalie
authors.initials: N
authors.lastname: de Rekeneire
authors.affiliation: Division of Cardiology, Stony Brook University, Long Island, New York, USA.
authors.forename: Javed
authors.initials: J
authors.lastname: Butler
authors.affiliation: Cardiology Division, Emory University, Atlanta, GA, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kalogeropoulos
authors.affiliation: Department of Medicine, University of California, San Francisco, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, USA.
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Bauer
authors.affiliation: Sticht Center on Aging, Wake Forrest School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Kritchevsky
authors.affiliation: Center for Aging and Population Health, Department of Epidemiology, University of Pittsburgh, Pennsylvania, USA.
authors.forename: Iva
authors.initials: I
authors.lastname: Miljkovic
authors.affiliation: Department of Medicine, University of California, San Francisco, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Vittinghoff
authors.affiliation: Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD, USA.
authors.forename: Tamara
authors.initials: T
authors.lastname: Harris
authors.affiliation: Department of General Internal Medicine, Bern University Hospital, Switzerland. Electronic address: Nicolas.Rodondi@insel.ch.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Rodondi
mesh_terms: D000368:Aged; D000375:Aging; D001823:Body Composition; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology; D005260:Female; D005544:Forecasting; D006801:Humans; D015994:Incidence; D008297:Male; D011446:Prospective Studies; D052243:Resistin / Q000097:blood*; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D052243:Resistin
keywords: Biomarkers; Cardiovascular prevention; Cohort studies; Inflammation; Insulin resistance