title: Chemical immobilization of antimicrobial peptides on biomaterial surfaces.
abstract: The hospital infections associated with surgical procedures and implants still represents a severe problem to modern society. Therefore, new strategies to combat bacterial infections mainly caused by microorganisms resistant to conventional antibiotics are extremely necessary. In this context, antimicrobial peptides have gained prominence due their biocompatibility, low toxicity and effectiveness. The immobilization of antimicrobial peptides (AMPs) onto a biomaterial surface is an excellent alternative to the development of new biodevices with microbicide properties. Herein, we describe reports related to physical-chemical characterization, in vitro/in vivo studies and clinical applicability. In this review, we focused on the AMPs mechanisms of action, different peptide immobilization strategies on solid surface and their microbicide effectiveness.
authors.affiliation: Programa de Pos-Graduacao em Inovacao Terapeutica, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brasil.
authors.forename: Rafael R
authors.initials: RR
authors.lastname: Silva
authors.affiliation: Departamento de Bioquímica, Universidade Federal de Pernambuco, 50670-901, Recife, PE, Brasil.
authors.forename: Karen Y P S
authors.initials: KY
authors.lastname: Avelino
authors.affiliation: Programa de Pos-Graduacao em Inovacao Terapeutica, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brasil.
authors.forename: Kalline L
authors.initials: KL
authors.lastname: Ribeiro
authors.affiliation: Centro de Analise Proteomicas e Bioquimicas de Brasilia, Universidade Catolica de Brasília, 71966-700, Brasilia, DF, Brasil.
authors.forename: Octavio L
authors.initials: OL
authors.lastname: Franco
authors.affiliation: Departamento de Bioquímica, Universidade Federal de Pernambuco, 50670-901, Recife, PE, Brasil.
authors.forename: Maria D L
authors.initials: MD
authors.lastname: Oliveira
authors.affiliation: Programa de Pos-Graduacao em Inovacao Terapeutica, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brasil,2Departamento de Bioquímica, Universidade Federal de Pernambuco, 50670-901, Recife, PE, Brasil, csrandrade@gmail.com.
authors.forename: Cesar A S
authors.initials: CA
authors.lastname: Andrade
mesh_terms: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D001672:Biocompatible Materials; D010455:Peptides / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D001672:Biocompatible Materials; D010455:Peptides