title: Preparation of a New Chiral Stationary Phase Based on Macrocyclic Amide Chiral Selector for the Liquid Chromatographic Chiral Separations.
abstract: A new chiral stationary phase (CSP) based on macrocyclic amide receptor was prepared starting from (1R,2R)-1,2-diphenylethylenediamine. The new CSP was successfully applied to the resolution of various N-(substituted benzoyl)-α-amino amides with reasonably good separation factors and resolutions (α = 1.75 ~ 2.97 and RS  = 2.89 ~ 6.82 for 16 analytes). The new CSP was also applied to the resolution of 3-substituted 1,4-benzodiazepin-2-ones and some diuretic chiral drugs including bendroflumethiazide and methylchlothiazide and metolazone. The resolution results for 3-substituted 1,4-benzodiazepin-2-ones and some diuretic chiral drugs were also reasonably good.
authors.affiliation: Department of Chemistry, Pusan National University, Busan, Republic of Korea.
authors.forename: Ji Yeong
authors.initials: JY
authors.lastname: Sung
authors.affiliation: Department of Chemistry, Pusan National University, Busan, Republic of Korea.
authors.forename: Seung Hyuck
authors.initials: SH
authors.lastname: Choi
authors.affiliation: Department of Chemistry, Pusan National University, Busan, Republic of Korea.
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Hyun
keywords: chiral stationary phase; enantiomer separation; liquid chromatography; macrocyclic amide chiral selector