title: [Expressions of Estrogen Receptor,Progestogen Receptor,Cerb-B2,and Ki67 Index in the Simple Mucinous Carcinoma of the Breast].
abstract: OBJECTIVE
  To approach the expressions of estrogen receptor (ER),progestogen receptor (PR),Cerb-B2,and Ki67 index in simple mucinous carcinoma of the breast and their clinical significance.
  
  
  METHODS
  The clinicopathological data of 72 patients with simple mucinous carcinoma of the breast who were treated in our hospital from 1997 to 2012 were retrospectively studied. Expressions of ER,PR,Cerb-B2,and Ki67 index and their relationship with clinical characteristics were analyzed.
  
  
  RESULTS
  Nine patients had lymph node metastasis. Expressions of ER,PR,and Cerb-B2 were 77.8%,69.4%,and 3.1%,respectively. The expressions of ER,PR,and Cerb-B2 showed no correlation with age,menstrual status,and axillary lymph node metastasis (P>0.05). The expression of ER was correlated with tumor diameter (P=0.008) while the expression of PR and Cerb-B2 showed no such correlation.
  
  
  CONCLUSIONS
  High ER or PR expression and low Cerb-B2 expression predict good prognosis in patients with simple mucinous carcinoma of the breast. Combined detection of ER,PR,Cerb-B2,and Ki67 index may help to improve the multidisciplinary management of simple mucinous carcinoma of the breast.
authors.affiliation: Department of Breast Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100005,China.
authors.forename: Peng Li
authors.initials: PL
authors.lastname: Peng
authors.affiliation: Department of Pathology,PUMC Hospital,CAMS and PUMC,Beijing 100005,China.
authors.forename: Da-chun
authors.initials: DC
authors.lastname: Zhao
authors.affiliation: Department of Breast Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100005,China.
authors.forename: Yi-dong
authors.initials: YD
authors.lastname: Zhou
authors.affiliation: Department of Breast Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100005,China.
authors.forename: Feng
authors.initials: F
authors.lastname: Mao
authors.affiliation: Department of Breast Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100005,China.
authors.forename: Jia-lin
authors.initials: JL
authors.lastname: Zhao
authors.affiliation: Department of Breast Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100005,China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Sun
mesh_terms: D002288:Adenocarcinoma, Mucinous; D001943:Breast Neoplasms; D006801:Humans; D019394:Ki-67 Antigen; D008207:Lymphatic Metastasis; D011372:Progestins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D012189:Retrospective Studies
chemical_list: D019394:Ki-67 Antigen; D011372:Progestins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone