title: [Characteristics of persister cells and the diversity of type II toxin - antitoxin system in Acinetobacter baumannii].
abstract: OBJECTIVE
  To study the biological features of the Acinetobacter baumannii persisters and the correlation between Type II toxin-antitoxin systems (TAs) and the persisters.
  
  
  METHODS
  Different antibiotics were used to isolate the persisters; BLAST programs were adopted to analyze candidate TAs; PCR was used to detect the distribution of TAs.
  
  
  RESULTS
  The number of persisters was different when treated by different antibiotics. For most antibiotics, the higher the concentration used, the lower the persister number was obtained. Persister numbers in exponential phase populations were lower than that in stationary phase. Polymyxin B and tobramycin could kill persisters.
  
  
  CONCLUSIONS
  The persistence level of A. baumannii is related to the growth state of the strains, the class and concentration of antibiotics.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Ma
authors.forename: Yuying
authors.initials: Y
authors.lastname: Zhu
authors.forename: Weicheng
authors.initials: W
authors.lastname: Li
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.forename: Na
authors.initials: N
authors.lastname: Lv
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Baoli
authors.initials: B
authors.lastname: Zhu
authors.forename: Yongfei
authors.initials: Y
authors.lastname: Hu
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000992:Antitoxins / Q000378:metabolism*; D001427:Bacterial Toxins / Q000378:metabolism*; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D000992:Antitoxins; D001427:Bacterial Toxins