title: Evolving Strategies in the Treatment of Tuberous Sclerosis Complex-associated Angiomyolipomas (TSC-AML).
abstract: Tuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disorder characterized by the development of numerous benign tumors that occur in multiple organ systems throughout the lifetime of the affected individuals. Renal angiomyolipomas occur in up to 80% of TSC patients, and chronic kidney disease from increasing tumor burden is the primary cause of TSC-related mortality. Our review evaluates evidence for localized and systemic therapy in the management of TSC-angiomyolipomas. Urologists or nephrologists experienced in TSC disease should coordinate the care of TSC patients with renal involvement to improve care and reduce costs.
authors.affiliation: Division of Urology, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Anil
authors.initials: A
authors.lastname: Kapoor
authors.affiliation: Department of Medicine, The University of Calgary, Alberta, Canada.
authors.forename: Louis
authors.initials: L
authors.lastname: Girard
authors.affiliation: Department of Surgery, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Lattouf
authors.affiliation: University Health Network, Toronto General Hospital, Toronto, Ontario, Canada.
authors.forename: York
authors.initials: Y
authors.lastname: Pei
authors.affiliation: QEII Health Sciences Centre-Department of Urology, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Rendon
authors.affiliation: Kaleidoscope Strategic, Toronto, Ontario, Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Card
authors.affiliation: University of British Columbia, BCCA, Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada. Electronic address: dralanso@mail.ubc.ca.
authors.forename: Alan
authors.initials: A
authors.lastname: So
mesh_terms: D018207:Angiomyolipoma / Q000628:therapy*; D058070:Asymptomatic Diseases; D003663:Decision Trees; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000628:therapy*; D017410:Practice Guidelines as Topic; D014402:Tuberous Sclerosis