title: Au nanoparticle-based sensor for apomorphine detection in plasma.
abstract: Artificially roughened gold surfaces with controlled nanostructure produced by pulsed laser deposition have been investigated as sensors for apomorphine detection aiming at clinical application. The use of such gold surfaces has been optimized using aqueous solutions of apomorphine in the concentration range between 3.3 × 10(-4) M and 3.3 × 10(-7) M. The experimental parameters have been investigated and the dynamic concentration range of the sensor has been assessed by the selection of two apomorphine surface enhanced Raman scattering (SERS) peaks. The sensor behavior used to detect apomorphine in unfiltered human blood plasma is presented and discussed.
authors.affiliation: Dipartimento di Energia, Politecnico di Milano, Via Ponzio 34/3, 20133 Milano, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Zanchi
authors.affiliation: Dipartimento di Chimica, Materiali e Ingegneria Chimica 'Giulio Natta', Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Lucotti
authors.affiliation: Dipartimento di Chimica, Materiali e Ingegneria Chimica 'Giulio Natta', Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Tommasini
authors.affiliation: CNR-IPCF, Istituto per i Processi Chimico-Fisici del CNR, V.le. F. S. D'Alcontres 37, 98158 Messina, Italy.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Trusso
authors.affiliation: Laboratorio di Patologia Clinica e Genetica Medica, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, Italy.
authors.forename: Ugo
authors.initials: U
authors.lastname: de Grazia
authors.affiliation: Laboratorio di Patologia Clinica e Genetica Medica, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, Italy.
authors.forename: Emilio
authors.initials: E
authors.lastname: Ciusani
authors.affiliation: Dipartimento di Energia, Politecnico di Milano, Via Ponzio 34/3, 20133 Milano, Italy.
authors.forename: Paolo M
authors.initials: PM
authors.lastname: Ossi
keywords: Au NPs; SERS; apomorphine; nano-roughened films; pulsed laser deposition; self-assembled films