title: Locomotion and eye behaviour under controlled environment in individuals with Alzheimer's disease.
abstract: This study aimed to examine simple locomotion and eye behaviour of individuals with Posterior Cortical Atrophy (PCA) and typical Alzheimer's disease (tAD) within a simulated real-world environment. Posterior cortical atrophy (PCA) is a neurodegenerative condition characterised by parietal, occipital and occipito-temporal tissue loss and progressive impairment of higher-order visual function in contrast to relatively spared memory and language. Targeted types of locomotion were walking in a series of corridors, up or down stairs, and across an open room with or without the presence of an obstacle. Eye tracking measures and inertial moment units (IMU) were used in this experiment, and resultant acceleration of left foot and fixation duration were extracted. Findings from three participants are presented as a case series: one control, one PCA and one tAD patient. The averaged resultant acceleration of PCA patient was the slowest in all types of locomotion, especially in stairs. The averaged resultant accelerations of PCA and tAD participants were slower than the control participant. The PCA participant had longer mean fixation durations than the tAD and control participants, however, mean fixation duration was similar between tAD and control participants. Results may help characterise locomotion and eye behaviour in PCA and tAD and may suggest ways to support effective diagnosis and assessment of disease progression.
authors.forename: Tatsuto
authors.initials: T
authors.lastname: Suzuki
authors.forename: Keir
authors.initials: K
authors.lastname: Yong
authors.forename: Biao
authors.initials: B
authors.lastname: Yang
authors.forename: Amelia
authors.initials: A
authors.lastname: Carton
authors.forename: Ian
authors.initials: I
authors.lastname: McCarthy
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Papadosifos
authors.forename: Derrick
authors.initials: D
authors.lastname: Boampong
authors.forename: Catherine
authors.initials: C
authors.lastname: Holloway
authors.forename: Nick
authors.initials: N
authors.lastname: Tyler
authors.forename: Sebastian
authors.initials: S
authors.lastname: Crutch
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology*; D001284:Atrophy; D018450:Disease Progression; D004780:Environment, Controlled; D005133:Eye Movements; D005260:Female; D006801:Humans; D008297:Male; D009778:Occipital Lobe / Q000473:pathology; D010296:Parietal Lobe / Q000473:pathology; D016138:Walking