title: Expression of tumor necrosis factor receptor-associated protein 1 and its clinical significance in kidney cancer.
abstract: OBJECTIVE
  To investigate the expression and clinical significance of TRAP1 (tumor necrosis factor receptor-associated protein 1) in kidney cancer.
  
  
  METHODS
  TRAP1 expression was detected in kidney cancer and normal kidney tissues by qRT-PCR and immunohistochemistry (IHC), respectively. Then, the correlation of TRAP1 expression with clinicopathological characters and patients' prognosis was evaluated in kidney cancer.
  
  
  RESULTS
  IHC results revealed that the high-expression rates of TRAP1 in kidney cancer tissues and normal kidney tissues were 51.3% (41/80), 23.3% (7/30), and the difference was statistically significant (P=0.01). Also, TRAP1 mRNA level in kidney cancer was found to be significantly greater compared with those in normal kidney by qRT-PCR. In addition, TRAP1 expression in kidney cancer significantly correlated with lymph node metastasis and clinical stage (P<0.05). Kaplan-Meier survival analysis indicated that the mean survival time of patients with TRAP1 low-expression was significantly higher (56 months) than those patients with TRAP1 high-expression (47 months). Meanwhile, Kaplan-Meier and Cox survival analysis indicated that TRAP1, lymph node metastasis and clinical stage were correlated with patients' prognosis.
  
  
  CONCLUSIONS
  TRAP1 is highly expressed in kidney cancer and correlates with patients prognosis, which may be served as a potential marker for the diagnosis and treatment of kidney cancer.
authors.affiliation: Department of Urology, Guangdong No. 2 Provincial People's Hospital Guangzhou, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Si
authors.affiliation: Department of Urology, Guangdong No. 2 Provincial People's Hospital Guangzhou, China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Urology, Guangdong No. 2 Provincial People's Hospital Guangzhou, China.
authors.forename: Xiaofu
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Department of Urology, Guangdong No. 2 Provincial People's Hospital Guangzhou, China.
authors.forename: Youhua
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Urology, Guangdong No. 2 Provincial People's Hospital Guangzhou, China.
authors.forename: Baichuan
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Urology, Guangdong No. 2 Provincial People's Hospital Guangzhou, China.
authors.forename: Bingwei
authors.initials: B
authors.lastname: Wang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D018841:HSP90 Heat-Shock Proteins / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D007680:Kidney Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D018841:HSP90 Heat-Shock Proteins; C092306:TRAP1 protein, human
keywords: Kidney cancer; TRAP1; clinical stage; histological grade; lymph node metastasis; prognosis