title: Sparse generalized volterra model of human hippocampal spike train transformation for memory prostheses.
abstract: In order to build hippocampal prostheses for restoring memory functions, we build multi-input, multi-output (MIMO) nonlinear dynamical models of the human hippocampus. Spike trains are recorded from the hippocampal CA3 and CA1 regions of epileptic patients performing a memory-dependent delayed match-to-sample task. Using CA3 and CA1 spike trains as inputs and outputs respectively, second-order sparse generalized Laguerre-Volterra models are estimated with group lasso and local coordinate descent methods to capture the nonlinear dynamics underlying the spike train transformations. These models can accurately predict the CA1 spike trains based on the ongoing CA3 spike trains and thus will serve as the computational basis of the hippocampal memory prosthesis.
authors.forename: Dong
authors.initials: D
authors.lastname: Song
authors.forename: Brian S
authors.initials: BS
authors.lastname: Robinson
authors.forename: Robert E
authors.initials: RE
authors.lastname: Hampson
authors.forename: Vasilis Z
authors.initials: VZ
authors.lastname: Marmarelis
authors.forename: Sam A
authors.initials: SA
authors.lastname: Deadwyler
authors.forename: Theodore W
authors.initials: TW
authors.lastname: Berger
mesh_terms: D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D017711:Nonlinear Dynamics