title: Comparing the Structure-Function Relationship at the Macula With Standard Automated Perimetry and Microperimetry.
abstract: OBJECTIVE
  To compare the structure-function relationship between ganglion cell-inner plexiform layer (GCIPL) thickness measurements using spectral-domain optical coherence tomography (SDOCT) and visual sensitivities measured using standard automated perimetry (SAP) and microperimetry (MP) at the macula in glaucoma.
  
  
  METHODS
  In a prospective study, 45 control eyes (29 subjects) and 60 glaucoma eyes (45 patients) underwent visual sensitivity estimation at the macula (central 10°) by SAP and MP, and GCIPL thickness measurement at the macula by SDOCT. Structure-function relationships between GCILP thickness and visual sensitivity loss with SAP and MP at various macular sectors were assessed using the Hood and Kardon model. To compare structure-function relationship with SAP and MP, we calculated the number of data points falling outside the 5th and the 95th percentile values of the Hood and Kardon model with each of the perimeters.
  
  
  RESULTS
  The number of points falling outside the 5th and 95th percentile values of the Hood and Kardon model ranged from 28 (superior sector) to 48 (inferonasal sector) with SAP and 33 (superior sector) to 49 (inferonasal sector) with MP. The difference in the number of points falling outside the 5th and 95th percentile values with SAP and MP was statistically insignificant (P > 0.05, χ(2) test) for all the sectors.
  
  
  CONCLUSIONS
  Visual sensitivity measurements of both SAP and MP demonstrated a similar relationship with the GCIPL measurements of SDOCT at the macula in glaucoma.
authors.affiliation: VST Glaucoma Center L V Prasad Eye Institute, Banjara Hills, Hyderabad, India 2Narayana Nethralaya, Rajajinagar, Bangalore, India.
authors.forename: Harsha L
authors.initials: HL
authors.lastname: Rao
authors.affiliation: VST Glaucoma Center L V Prasad Eye Institute, Banjara Hills, Hyderabad, India.
authors.forename: Manideepak
authors.initials: M
authors.lastname: Januwada
authors.affiliation: VST Glaucoma Center L V Prasad Eye Institute, Banjara Hills, Hyderabad, India.
authors.forename: Raza S M
authors.initials: RS
authors.lastname: Hussain
authors.affiliation: VST Glaucoma Center L V Prasad Eye Institute, Banjara Hills, Hyderabad, India.
authors.forename: Lalitha N
authors.initials: LN
authors.lastname: Pillutla
authors.affiliation: VST Glaucoma Center L V Prasad Eye Institute, Banjara Hills, Hyderabad, India.
authors.forename: Viquar U
authors.initials: VU
authors.lastname: Begum
authors.affiliation: VST Glaucoma Center L V Prasad Eye Institute, Banjara Hills, Hyderabad, India.
authors.forename: Aditya
authors.initials: A
authors.lastname: Chaitanya
authors.affiliation: VST Glaucoma Center L V Prasad Eye Institute, Banjara Hills, Hyderabad, India.
authors.forename: Sirisha
authors.initials: S
authors.lastname: Senthil
authors.forename: Chandra S
authors.initials: CS
authors.lastname: Garudadri
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005901:Glaucoma / Q000503:physiopathology*; D006801:Humans; D008266:Macula Lutea / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000503:physiopathology*; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000502:physiology*; D041623:Tomography, Optical Coherence / Q000379:methods; D058609:Visual Field Tests / Q000379:methods; D014794:Visual Fields / Q000502:physiology*