title: [Multiple linear regression and ROC curve analysis of the factors of lumbar spine bone mineral density].
abstract: OBJECTIVE
  To investigate the correlation between the lumbar vertebra bone mineral density (BMD) and age, gender, height, weight, body mass index, waistline, hipline, bone marrow and abdomen fat, and to explore the key factor affecting the BMD.
  
  
  METHODS
  A total of 72 cases were randomly recruited. All the subjects underwent a spectroscopic examination of the third lumber vertebra with single-voxel method in 1.5T MR. Lipid fractions (FF%) were measured. Quantitative CT were also performed to get the BMD of L3 and the corresponding abdomen subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). The statistical analysis were performed by SPSS 19.0.
  
  
  RESULTS
  Multiple linear regression showed except the age and FF% showed significant difference (P<0.05) , the gender, height, weight, BMI, waistline, hipline, SAT and VAT showed no significant difference (P>0.05). The correlation of age and FF% with BMD was statistically negatively significant (r=-0.830, -0.521, P<0.05). The ROC curve analysis showed that the sensitivety and specificity of predicting osteoporosis were 81.8% and 86.9%, with a threshold of 58.5 years old. And it showed that the sensitivety and specificity of predicting osteoporosis were 90.9% and 55.7%, with a threshold of 52.8% for FF%.
  
  
  CONCLUSIONS
  The lumbar vertebra BMD was significantly and negatively correlated with age and bone marrow FF%, but it was not significantly correlated with gender, height, weight, BMI, waistline, hipline, SAT and VAT. And age was the critical factor.
authors.affiliation: Department of Medical Imaging, Third Affiliated Hospital, Southern Medical University, the Institute of Medical Imaging of Bone and Joints, Academy of Orthopedics Guangdong Province, Guangzhou 510630, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Medical Imaging, Third Affiliated Hospital, Southern Medical University, the Institute of Medical Imaging of Bone and Joints, Academy of Orthopedics Guangdong Province, Guangzhou 510630, China.
authors.forename: Yinxia
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Medical Imaging, Third Affiliated Hospital, Southern Medical University, the Institute of Medical Imaging of Bone and Joints, Academy of Orthopedics Guangdong Province, Guangzhou 510630, China.
authors.forename: Shaoyong
authors.initials: S
authors.lastname: Hu
authors.affiliation: Department of Medical Imaging, Third Affiliated Hospital, Southern Medical University, the Institute of Medical Imaging of Bone and Joints, Academy of Orthopedics Guangdong Province, Guangzhou 510630, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Hao
authors.affiliation: Department of Medical Imaging, Third Affiliated Hospital, Southern Medical University, the Institute of Medical Imaging of Bone and Joints, Academy of Orthopedics Guangdong Province, Guangzhou 510630, China.
authors.forename: Jiewen
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Medical Imaging, Third Affiliated Hospital, Southern Medical University, the Institute of Medical Imaging of Bone and Joints, Academy of Orthopedics Guangdong Province, Guangzhou 510630, China.
authors.forename: Lingyan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Medical Imaging, Third Affiliated Hospital, Southern Medical University, the Institute of Medical Imaging of Bone and Joints, Academy of Orthopedics Guangdong Province, Guangzhou 510630, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Medical Imaging, Third Affiliated Hospital, Southern Medical University, the Institute of Medical Imaging of Bone and Joints, Academy of Orthopedics Guangdong Province, Guangzhou 510630, China; Email: lishaolin1963@126.com.
authors.forename: Shaolin
authors.initials: S
authors.lastname: Li
mesh_terms: D050153:Abdominal Fat; D015992:Body Mass Index; D001835:Body Weight; D015519:Bone Density; D001853:Bone Marrow; D006801:Humans; D050152:Intra-Abdominal Fat; D016014:Linear Models; D008055:Lipids; D008159:Lumbar Vertebrae; D015999:Multivariate Analysis; D010024:Osteoporosis; D012372:ROC Curve
chemical_list: D008055:Lipids