title: Profile of Cytokines and Chemokines Triggered by Wild-Type Strains of Rabies Virus in Mice.
abstract: Rabies is a lethal infectious disease that causes 55,000 human deaths per year and is transmitted by various mammalian species, such as dogs and bats. The host immune response is essential for avoiding viral progression and promoting viral clearance. Cytokines and chemokines are crucial in the development of an immediate antiviral response; the rabies virus (RABV) attempts to evade this immune response. The virus's capacity for evasion is correlated with its pathogenicity and the host's inflammatory response, with highly pathogenic strains being the most efficient at hijacking the host's defense mechanisms and thereby decreasing inflammation. The purpose of this study was to evaluate the expression of a set of cytokine and chemokine genes that are related to the immune response in the brains of mice inoculated intramuscularly or intracerebrally with two wild-type strains of RABV, one from dog and the other from vampire bat. The results demonstrated that the gene expression profile is intrinsic to the specific rabies variant. The prompt production of cytokines and chemokines seems to be more important than their levels of expression for surviving a rabies infection.
authors.affiliation: Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
authors.forename: Camila Michele
authors.initials: CM
authors.lastname: Appolinário
authors.affiliation: Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
authors.forename: Susan Dora
authors.initials: SD
authors.lastname: Allendorf
authors.affiliation: Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
authors.forename: Marina Gea
authors.initials: MG
authors.lastname: Peres
authors.affiliation: Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
authors.forename: Bruna Devidé
authors.initials: BD
authors.lastname: Ribeiro
authors.affiliation: Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
authors.forename: Clóvis R
authors.initials: CR
authors.lastname: Fonseca
authors.affiliation: Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
authors.forename: Acácia Ferreira
authors.initials: AF
authors.lastname: Vicente
authors.affiliation: Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
authors.forename: João Marcelo A de Paula
authors.initials: JM
authors.lastname: Antunes
authors.affiliation: Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil jane@fmvz.unesp.br.
authors.forename: Jane
authors.initials: J
authors.lastname: Megid
mesh_terms: D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D012313:RNA / Q000235:genetics / Q000378:metabolism; D011818:Rabies / Q000276:immunology* / Q000821:virology*; D011820:Rabies virus / Q000276:immunology*; D013047:Specific Pathogen-Free Organisms; D059467:Transcriptome
chemical_list: D016207:Cytokines; D012313:RNA