title: Novel Attributions of TREMs in Immunity.
abstract: The emerging role of the TREMs (Triggering Receptors Expressed by Myeloid cells) family in inflammation makes it important to explore their molecular mechanisms governing key pathways in inflammatory diseases. The TREMs family interaction with microbial products make it a strong candidate to target inflammatory diseases and raises an important question of its potential as a useful target in inflammatory diseases caused by products other than microbes, for example psoriasis. The interaction of TREMs with various immune responses can be of key importance in handling inflammatory diseases. The well established interaction of TREM-1 with microbial products like LPS and the emerging interactions with products from different important diseases of brain, heart, lungs and skin demands its full investigation as a therapeutic target. The post translational modifications (PTMs) that might regulate the functions of genes are also discussed and its future potential is reviewed. Furthermore, Its close cross talk with TLRs, NLRs and NODs is also reviewed in context of developing novel therapeutics.
authors.affiliation: Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education China, Huazhong Agricultural University, Wuhan 430070, People's Republic of China.
authors.forename: Nuruliarizki Shinta
authors.initials: NS
authors.lastname: Pandupuspitasari
authors.forename: Faheem Ahmed
authors.initials: FA
authors.lastname: Khan
authors.forename: Chun-Jie
authors.initials: CJ
authors.lastname: Huang
authors.forename: Xing
authors.initials: X
authors.lastname: Chen
authors.forename: ShuJun
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D006801:Humans; D007113:Immunity, Innate; D011971:Receptors, Immunologic / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D011971:Receptors, Immunologic