title: Nivolumab causing painless thyroiditis in a patient with adenocarcinoma of the lung.
abstract: Thyroiditis is characterised by transient hyperthyroidism, followed sometimes by hypothyroidism, and then recovery. We report a case of painless drug-induced thyroiditis-in a patient with no history of any thyroid disorder-treated with Nivolumab (an IgG4 monoclonal antibody against Programmed Death Receptor 1). The purpose of this case report is to increase awareness among clinicians regarding this possible adverse effect from Nivolumab, and discuss the possible pathophysiology and management strategies in such patients.
authors.affiliation: Department of Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.
authors.forename: Isha
authors.initials: I
authors.lastname: Verma
authors.affiliation: Division of Endocrinology, Diabetes & Metabolism, Cooper University Hospital, Camden, New Jersey, USA.
authors.forename: Anar
authors.initials: A
authors.lastname: Modi
authors.affiliation: Mower Central Research Lab, Sinai Hospital of Baltimore, Baltimore, Maryland, USA.
authors.forename: Hemantkumar
authors.initials: H
authors.lastname: Tripathi
authors.affiliation: Department of Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.
authors.forename: Abhinav
authors.identifier: http://orcid.org/0000-0003-1080-6449
authors.initials: A
authors.lastname: Agrawal
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008875:Middle Aged; D000077594:Nivolumab; D013966:Thyroiditis / Q000139:chemically induced*; D013971:Thyrotoxicosis / Q000209:etiology
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D000077594:Nivolumab