title: Tigroid background in cytology of hyalinizing clear cell carcinoma of the salivary gland.
abstract: Hyalinizing clear cell carcinoma (HCCC) is a rare and low grade salivary gland carcinoma with a unique recurrent EWSR1 gene translocation. HCCC most commonly arises from intraoral minor salivary glands and its cytological features have not been well evaluated. We report a 28-year-old man with palatal HCCC and emphasize the "tigroid background" and metachromatic matrix observed in scrape cytology. This "tigroid background," usually associated with glycogen-rich clear cell tumors, is an important cytological feature of HCCC. Awareness of this feature can do great help in pathological research and diagnosis.
authors.affiliation: Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Chang-Tsu
authors.initials: CT
authors.lastname: Yuan
authors.affiliation: Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Min-Shu
authors.initials: MS
authors.lastname: Hsieh
mesh_terms: D051697:Activating Transcription Factor 1 / Q000235:genetics*; D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D000328:Adult; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D015870:Gene Expression; D015321:Gene Rearrangement; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins / Q000235:genetics*; D012468:Salivary Gland Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D012469:Salivary Glands / Q000378:metabolism / Q000473:pathology / Q000601:surgery
chemical_list: C531110:ATF1 protein, human; D051697:Activating Transcription Factor 1; D002148:Calmodulin-Binding Proteins; C500986:EWSR1 protein, human; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins
keywords: cytology; hyalinizing clear cell carcinoma; tigroid background