title: A Review of the Application of Body-on-a-Chip for Drug Test and Its Latest Trend of Incorporating Barrier Tissue.
abstract: High-quality preclinical bioassay models are essential for drug research and development. We reviewed the emerging body-on-a-chip technology, which serves as a promising model to overcome the limitations of traditional bioassay models, and introduced existing models of body-on-a-chip, their constitutional details, application for drug testing, and individual features of these models. We put special emphasis on the latest trend in this field of incorporating barrier tissue into body-on-a-chip and discussed several remaining challenges of current body-on-a-chip.
authors.affiliation: Department of Pathophysiology, College of Basic Medicine, China Medical University, Undergraduate, Shenyang, China.
authors.forename: Haoyi
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Pathophysiology, College of Basic Medicine, China Medical University, Undergraduate, Shenyang, China yqyu@mail.cmu.edu.cn.
authors.forename: Yanqiu
authors.initials: Y
authors.lastname: Yu
mesh_terms: D001681:Biological Assay / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D055808:Drug Discovery / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D006801:Humans; D056656:Lab-On-A-Chip Devices / Q000639:trends; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods* / Q000639:trends
keywords: ADME; bioassay model; chip technology and methods; high-content screening; microfluidics