title: Favorable Outcomes of Hepatectomy for Ruptured Hepatocellular Carcinoma: Retrospective Analysis of Primary R0-Hepatectomized Patients.
abstract: OBJECTIVE
  The rupture of hepatocellular carcinoma (HCC) is defined as a detrimental staging factor. The aim of the present study was to elucidate whether the prognosis of surgical patients with ruptured HCC was truly appalling.
  
  
  METHODS
  The data obtained from the medical records of 1,031 patients who underwent primary R0 hepatecomy for HCC between August 2003 and November 2014 at the Department of Surgery and Science, Kyushu University Hospital and its two affiliated hospitals, were retrospectively analyzed. Twenty-seven patients had ruptured HCC.
  
  
  RESULTS
  The recurrence-free and overall survival for patients with ruptured HCC were favorable. All 19 patients with ruptured HCC who experienced recurrence had intrahepatic recurrence, while only three had peritoneal recurrence. The multivariate risk factor analyses showed that rupture itself was not relevant to recurrence-free survival nor to overall patient survival.
  
  
  CONCLUSIONS
  Rupture itself does not have much relevance to the outcome for patients who undergo hepatectomy.
authors.affiliation: Department of Surgery and Science, Kyushu University Hospital, Fukuoka, Japan huchi@surg2.med.kyushu-u.ac.jp.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Uchiyama
authors.affiliation: Department of Hepato-Biliary Pancreatic Surgery, Fukuoka City Hospital, Fukuoka, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Minagawa
authors.affiliation: Department of Surgery and Science, Kyushu University Hospital, Fukuoka, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Itoh
authors.affiliation: Department of Hepato-Biliary Pancreatic Surgery, Fukuoka City Hospital, Fukuoka, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kajiyama
authors.affiliation: Department of Surgery and Science, Kyushu University Hospital, Fukuoka, Japan.
authors.forename: Norifumi
authors.initials: N
authors.lastname: Harimoto
authors.affiliation: Department of Surgery and Science, Kyushu University Hospital, Fukuoka, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Ikegami
authors.affiliation: Department of Surgery and Science, Kyushu University Hospital, Fukuoka, Japan.
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Yoshizumi
authors.affiliation: Department of Surgery and Science, Kyushu University Hospital, Fukuoka, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Shirabe
authors.affiliation: Department of Hepato-Biliary Pancreatic Surgery, Fukuoka City Hospital, Fukuoka, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Takenaka
authors.affiliation: Department of Surgery and Science, Kyushu University Hospital, Fukuoka, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Rupture; hepatocellular carcinoma; recurrence; survival