title: Clinical Analysis of Familial Nonmedullary Thyroid Carcinoma.
abstract: OBJECTIVE
  To analyze the clinical characteristics of familial nonmedullary thyroid carcinoma (FNMTC), in order to provide evidence for early diagnosis and treatment.
  
  
  METHODS
  We retrospectively investigated the inpatients between September 2006 and September 2013 in the First Bethune Hospital of Jilin University, in which 78 patients with FNMTC from 31 families were analyzed by a comparison with 3445 control cases from the patients with sporadic nonmedullary thyroid carcinoma (SNMTC).
  
  
  RESULTS
  There was no significant difference in gender, age, and tumor size between FNMTC and SNMTC patients. However, the characteristics of disease in multifoci, neck lymph node metastasis, invasion to the surrounding tissues, and coexistence with Hashimoto disease in two types of cancer patients show significant difference. They are: multifoci: 71.8% (56/78) in FNMTC versus 46.3% (1595/3445) in SNMTC; neck lymph node metastasis: 52.6% (41/78) in FNMTC versus 33.3% (1148/3445) in SNMTC; surrounding tissue invasion: 64.1% (50/78) in FNMTC versus 48.5% (1670/3445) in SNMTC; coexistence with Hashimoto disease: 30.8% (24/78) in FNMTC versus 20.0% (689/3445) in SNMTC.
  
  
  CONCLUSIONS
  Lymph node metastasis, multifoci, invasion to the surrounding tissues, and combination with chronic lymphocytic thyroiditis are the main features of FNMTC, which suggests the extent of the operation for FNMTC patients should be amplified properly.
authors.affiliation: Department of Thyroid Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, People's Republic of China. jluzhangqiang@163.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Thyroid Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, People's Republic of China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Thyroid Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, People's Republic of China. 7919728@qq.com.
authors.forename: Xian-ying
authors.initials: XY
authors.lastname: Meng
authors.affiliation: Department of Thyroid Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, People's Republic of China.
authors.forename: Guang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Thyroid Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, People's Republic of China.
authors.forename: Ren-zhu
authors.initials: RZ
authors.lastname: Pang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000175:diagnosis* / Q000628:therapy; D002291:Carcinoma, Papillary; D002648:Child; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000628:therapy; D055815:Young Adult