title: Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa.
abstract: Two new cytotoxic furoquinoline alkaloids were isolated from the leaves of Aegle marmelos (Linn.) Correa; one from the total alkaloidal fraction (acid/base shake-out method) of the CHCl3extract and identified as 7,8-dihydroxy-4-hydrofuroquinoline and named trivially as Aegelbine-A. The other new alkaloid isolated from the pet. ether extract and identified as 4-hydro-7-hydroxy-8-prenyloxyfuroquinoline and named trivially as Aegelbine-B, together with a known alkaloid; aegeline and a known phenolic acid; ρ-hydroxybenzoic acid. The structures of all the isolated compounds were established based on 1D and 2D NMR spectroscopy and HR-ESI/MS. The cytotoxic activity of the isolated compounds was evaluated in vitro against HepG-2, PC3, A549 and MCF-7 cell lines. The obtained results revealed promising activity with structure-based relationship which is discussed briefly.
authors.affiliation: a Nucleic Acid Center, Institute of Physics, Chemistry and Pharmacy , University of Southern Denmark , Odense M , Denmark.|b Pharmaceutical and Drug Industries Research Division, Pharmacognosy Department , National Research Centre , Cairo , Egypt.
authors.forename: Magdy M D
authors.initials: MMD
authors.lastname: Mohammed
authors.affiliation: b Pharmaceutical and Drug Industries Research Division, Pharmacognosy Department , National Research Centre , Cairo , Egypt.
authors.forename: Nabaweya A
authors.initials: NA
authors.lastname: Ibrahim
authors.affiliation: c Faculty of Pharmacy, Pharmacognosy Department , Cairo University , Giza , Egypt.
authors.forename: Fatma S
authors.initials: FS
authors.lastname: El-Sakhawy
authors.affiliation: b Pharmaceutical and Drug Industries Research Division, Pharmacognosy Department , National Research Centre , Cairo , Egypt.
authors.forename: Khaled M
authors.initials: KM
authors.lastname: Mohamed
authors.affiliation: b Pharmaceutical and Drug Industries Research Division, Pharmacognosy Department , National Research Centre , Cairo , Egypt.
authors.forename: Doaa A-H
authors.initials: DA
authors.lastname: Deabes
keywords: Aegle marmelos (Linn.) Correa; cytotoxicity; furoquinoline alkaloids; rutaceae; structure–activity relationship studies