title: Protease-activated receptors and their biological role - focused on skin inflammation.
abstract: OBJECTIVE
  For several years, protease-activated receptors (PARs) are targets of science regarding to various diseases and platelet aggregation. In the past, a number of publications related to PARs have been published, which refer to a variety of aspects. An important point of view is the inflammation of the skin, which has not been reported in detail yet. This review will provide an overview of the current knowledge on PARs, and in particular, on the involvement of PARs in terms of skin inflammation.
  
  
  RESULTS
  Wound healing is an important step after skin injury and is connected with involvement of PARs and inflammation. An important point in skin inflammation is the coagulation-dependent skin inflammation.
  
  
  CONCLUSIONS
  PARs are a special kind of receptors, being activated by proteolytic cleavage or chemical agonists. They may play an important role in various physiological processes. It is shown that the proteases are involved in many diseases for example Parkinson's disease and Alzheimer's disease. The fact, that proteases regulate the coagulation, and are involved in interleukin and cytokine release leads to the conclusion that they are involved in inflammation processes.
authors.affiliation: Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Guenther
authors.affiliation: Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany.
authors.forename: Matthias F
authors.initials: MF
authors.lastname: Melzig
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D016207:Cytokines / Q000378:metabolism; D003872:Dermatitis / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D044462:Receptors, Proteinase-Activated / Q000378:metabolism*; D015398:Signal Transduction; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D014945:Wound Healing
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D044462:Receptors, Proteinase-Activated
keywords: molecular and clinical pharmacology; molecular and receptor pharmacology