title: Morbidity in preterm infants with fetal inflammatory response syndrome.
abstract: BACKGROUND
  The aim of this study was to evaluate the relationship between umbilical cord blood interleukin (IL)-6 concentration and preterm morbidity and mortality in premature infants born with fetal inflammatory response syndrome (FIRS).
  
  
  METHODS
  This prospective, observational study included 84 preterm infants with a gestational age of 24-36 weeks who had been admitted to the neonatal intensive care unit (NICU). FIRS was defined as umbilical cord blood IL-6 > 11 pg/mL. In premature infants with FIRS, morbidities (multiple organ failure [MOF], respiratory distress syndrome [RDS], patent ductus arteriosus, intraventricular hemorrhage, bronchopulmonary dysplasia, retinopathy of prematurity) and death were evaluated. Critical umbilical cord blood IL-6 concentrations for the development of RDS, death, and for MOF were determined in premature infants with FIRS.
  
  
  RESULTS
  Fifty-two infants with IL-6 concentration > 11 pg/mL constituted the FIRS group. Thirty-two infants without FIRS served as a control group. RDS, MOF, and mortality were significantly higher in the FIRS group (P = 0.001, P = 0.001, and P = 0.005, respectively). Umbilical cord blood IL-6 concentration > 26.7 pg/mL in the FIRS group was found to be predictive of RDS, with 70% sensitivity and 85% specificity. Umbilical cord blood IL-6 concentration > 37.7 pg/mL was found to be predictive of death, with 78.6% sensitivity and 60% specificity. The predictive value of IL-6 for the development of MOF was 17.5 pg/mL, with 91% sensitivity and 66% specificity.
  
  
  CONCLUSIONS
  Umbilical cord blood IL-6 concentration > 26.7, 37.7, and 17.5 pg/mL in premature infants with FIRS was found to be predictive for RDS, death, and MOF, respectively.
authors.affiliation: Zeynep Kamil Maternity and Children's Training Hospital, Istanbul, Turkey. elifozalkay@gmail.com.
authors.forename: Elif
authors.initials: E
authors.lastname: Ozalkaya
authors.affiliation: Zeynep Kamil Maternity and Children's Training Hospital, Istanbul, Turkey.
authors.forename: Güner
authors.initials: G
authors.lastname: Karatekin
authors.affiliation: Zeynep Kamil Maternity and Children's Training Hospital, Istanbul, Turkey.
authors.forename: Sevilay
authors.initials: S
authors.lastname: Topcuoğlu
authors.affiliation: Zeynep Kamil Maternity and Children's Training Hospital, Istanbul, Turkey.
authors.forename: Tuğba
authors.initials: T
authors.lastname: Gürsoy
authors.affiliation: Zeynep Kamil Maternity and Children's Training Hospital, Istanbul, Turkey.
authors.forename: Fahri
authors.initials: F
authors.lastname: Ovalı
mesh_terms: D005260:Female; D005312:Fetal Blood; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood / Q000453:epidemiology*; D007363:Intensive Care Units, Neonatal; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009017:Morbidity / Q000639:trends; D011446:Prospective Studies; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood / Q000453:epidemiology*; D014421:Turkey / Q000453:epidemiology
chemical_list: D015850:Interleukin-6
keywords: fetal inflammatory response syndrome; multiple organ failure; preterm infants; squarfs