title: Intraoperative Oxygen Consumption During Liver Transplantation.
abstract: BACKGROUND
  The aim of this study was to investigate the changes in oxygen consumption during liver transplantation and to examine the relationship between intraoperatively elevated systemic oxygen consumption and postoperative liver function.
  
  
  METHODS
  This study was performed in 33 adult patients undergoing liver transplantation between September 2011 and March 2014. We measured intraoperative oxygen consumption through the use of indirect calorimetry, preoperative and intraoperative data, liver function tests, and postoperative complications and outcomes.
  
  
  RESULTS
  The mean age of patients was 52 ± 9.7 years; 14 (42%) of them were women. Average Model for End-Stage Liver Disease scores were 20 ± 8.9. Oxygen consumption significantly increased after reperfusion from 172 ± 30 mL/min during the anhepatic phase to 209 ± 30 mL/min (P < .0001). We divided patients into 2 groups according to the increase in oxygen consumption after reperfusion (oxygen consumption after reperfusion minus anhepatic phase oxygen consumption: 40 mL/min increase as cutoff). The higher consumption group had a longer cold ischemia time and higher postoperative aspartate aminotransferase and alanine aminotransferase levels as compared with the lower oxygen consumption group. There were no statistically significant differences in major postoperative complications, but the higher oxygen consumption group tended to have shorter hospital stays than the lower consumption group (58 versus 95 days).
  
  
  CONCLUSIONS
  We have demonstrated that oxygen consumption significantly increased after reperfusion. Furthermore, this increased oxygen consumption was associated with a longer cold ischemia time and shorter hospital stays.
authors.affiliation: Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shibata
authors.affiliation: Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan. Electronic address: matusakik@ybb.ne.jp.
authors.forename: T
authors.initials: T
authors.lastname: Matsusaki
authors.affiliation: Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Kaku
authors.affiliation: Department of Surgery, Okayama University Hospital, Okayama, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Umeda
authors.affiliation: Department of Surgery, Okayama University Hospital, Okayama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yagi
authors.affiliation: Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Morimatsu
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D050377:Cold Ischemia / Q000706:statistics & numerical data; D058625:End Stage Liver Disease / Q000097:blood / Q000601:surgery*; D005260:Female; D006801:Humans; D007430:Intraoperative Care / Q000706:statistics & numerical data*; D007902:Length of Stay; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000379:methods / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology; D011184:Postoperative Period; D015424:Reperfusion / Q000706:statistics & numerical data; D013997:Time Factors
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase