title: Understanding the chemically-reactive proteome.
abstract: The reactivity of amino acid residues in proteins is context-dependent and difficult to predict. Chemical biology can be used to understand the chemical modifications of proteins to help elucidate the nature of the reactive proteome. The resulting insights can be applied to pharmacoproteomics, target identification and molecular pathology.
authors.affiliation: Worldwide Medicinal Chemistry, Pfizer, 610 Main Street, Cambridge MA, 02139, USA. lyn.jones@pfizer.com.
authors.forename: Lyn H
authors.initials: LH
authors.lastname: Jones
mesh_terms: D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism*; D055808:Drug Discovery; D006801:Humans; D011499:Protein Processing, Post-Translational; D020543:Proteome / Q000737:chemistry* / Q000378:metabolism*; D040901:Proteomics / Q000379:methods
chemical_list: D000596:Amino Acids; D020543:Proteome