title: Successful Treatment of Genetically Profiled Pediatric Extranodal NK/T-Cell Lymphoma Targeting Oncogenic STAT3 Mutation.
abstract: Extranodal natural killer (NK)/T-cell lymphoma (ENKTCL) is a distinct type of non-Hodgkin lymphoma predominantly observed in Asian and Latin American adult males. A 12-year-old Hispanic female diagnosed with ENKTCL was enrolled in our genomic profiling research protocol. We identified specific somatic alterations consistent with diagnosis of ENKTCL as well as oncogenic mutations in MAP2K1 and STAT3. To our knowledge, this is the first report of an immunophenotypically confirmed and genetically profiled case of ENKTCL in a female pediatric patient in the United States, including its unique treatment and favorable outcome.
authors.affiliation: Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, Arizona.|Hyundai Cancer Genomics Center, Children's Hospital of Orange County, Orange, California.
authors.forename: Troy A
authors.initials: TA
authors.lastname: McEachron
authors.affiliation: Division of Oncology, Hyundai Cancer Institute, Children's Hospital of Orange County, Orange, California.
authors.forename: Ivan
authors.initials: I
authors.lastname: Kirov
authors.affiliation: Pediatric Hematology/Oncology Residency Program, School of Medicine, University of California-Irvine/Children's Hospital of Orange County, Orange, California.
authors.forename: Minkkwan
authors.initials: M
authors.lastname: Wungwattana
authors.affiliation: Pediatric Hematology/Oncology Fellowship Program, School of Medicine, University of California-Irvine/Children's Hospital of Orange County, Orange, California.
authors.forename: Daisy
authors.initials: D
authors.lastname: Cortes
authors.affiliation: Hyundai Cancer Genomics Center, Children's Hospital of Orange County, Orange, California.|Division of Hematology-Oncology, Department of Medicine, School of Medicine, University of California-Irvine, Orange, California.
authors.forename: Keri B
authors.initials: KB
authors.lastname: Zabokrtsky
authors.affiliation: Department of Pathology, Children's Hospital of Orange County, Orange, California.
authors.forename: Aaron
authors.initials: A
authors.lastname: Sassoon
authors.affiliation: Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona.
authors.forename: David
authors.initials: D
authors.lastname: Craig
authors.affiliation: Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, Arizona.
authors.forename: John D
authors.initials: JD
authors.lastname: Carpten
authors.affiliation: Hyundai Cancer Genomics Center, Children's Hospital of Orange County, Orange, California.|Division of Oncology, Hyundai Cancer Institute, Children's Hospital of Orange County, Orange, California.|Division of Hematology-Oncology, Department of Medicine, School of Medicine, University of California-Irvine, Orange, California.|Department of Pediatrics, School of Medicine, University of California-Irvine, Orange, California.
authors.forename: Leonard S
authors.initials: LS
authors.lastname: Sender
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage; D059248:Chemoradiotherapy / Q000379:methods*; D002648:Child; D003561:Cytarabine / Q000008:administration & dosage; D004252:DNA Mutational Analysis; D003907:Dexamethasone / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D006877:Hydroxamic Acids / Q000008:administration & dosage; D007069:Ifosfamide / Q000008:administration & dosage; D054391:Lymphoma, Extranodal NK-T-Cell / Q000235:genetics* / Q000628:therapy*; D048369:MAP Kinase Kinase 1 / Q000235:genetics; D008727:Methotrexate / Q000008:administration & dosage; D009154:Mutation; D000074462:Positive Regulatory Domain I-Binding Factor 1; D057285:Precision Medicine / Q000379:methods*; D012097:Repressor Proteins / Q000235:genetics; D050796:STAT3 Transcription Factor / Q000235:genetics*; D000077337:Vorinostat
chemical_list: D006877:Hydroxamic Acids; D012097:Repressor Proteins; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D003561:Cytarabine; C087042:PRDM1 protein, human; D000077337:Vorinostat; D005047:Etoposide; D003907:Dexamethasone; D000074462:Positive Regulatory Domain I-Binding Factor 1; D048369:MAP Kinase Kinase 1; C482125:MAP2K1 protein, human; D001215:Asparaginase; D007069:Ifosfamide; D006854:Hydrocortisone; D008727:Methotrexate
keywords: STAT3; extranodal NK/T-cell lymphoma; genome