title: In vivo photoacoustic tomography of myoglobin oxygen saturation.
abstract: Myoglobin is an essential oxygen-binding hemoprotein in skeletal and cardiac muscles that buffers intracellular oxygen (O2) concentration in response to hypoxia or elevated muscle activities. We present a method that uses photoacoustic computed tomography to measure the distribution of myoglobin in tissue and the oxygen saturation of myoglobin (sO2-Mb ). From photoacoustic measurements of mice in different oxygenation states, we performed calibration-free quantification of the sO2-Mb change in the backbone muscle in vivo.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.forename: Junjie
authors.initials: J
authors.lastname: Yao
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Lihong V
authors.initials: LV
authors.lastname: Wang
mesh_terms: D000818:Animals; D064131:Back Muscles / Q000378:metabolism*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D051379:Mice; D057054:Molecular Imaging / Q000295:instrumentation; D009211:Myoglobin / Q000378:metabolism*; D010092:Oximetry / Q000295:instrumentation*; D010100:Oxygen / Q000378:metabolism*; D061088:Photoacoustic Techniques / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000295:instrumentation*
chemical_list: D009211:Myoglobin; D010100:Oxygen