title: IL4 gene polymorphisms in Iranian patients with autoimmune hepatitis.
abstract: BACKGROUND
  Autoimmune hepatitis (AIH) is a chronic long-lasting hepatocellular inflammation associated with circulating auto antibodies. In addition to the genetic component, several cytokines have been implicated to be involved in AIH. This study was performed to investigate potential associations of AIH with IL4 gene variants.
  
  
  METHODS
  The studied alleles and genotypes included: IL4G/T allele polymorphisms at position -1098 and C/T allele polymorphisms at two positions (-33 and -590) on the IL4 gene, in addition to the A/G allele polymorphisms at position +1902 on the IL4RA gene.
  
  
  RESULTS
  The IL4 C allele and CC genotype at position -590 and TT genotype at position -33 had a significantly higher frequency in AIH patients.
  
  
  CONCLUSIONS
  This study identified the IL4 C allele and CC genotype susceptibility gene in AIH, which will provide better insights into the mechanisms of AIH and potential therapeutic interventions.
authors.affiliation: a Department of Gastroenterology, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Azizollah
authors.initials: A
authors.lastname: Yousefi
authors.affiliation: b Molecular Immunology Research Center; Department of Immunology, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Mahmoudi
authors.affiliation: c Thrombosis Hemostasis Research Center , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Zare Bidoki
authors.affiliation: b Molecular Immunology Research Center; Department of Immunology, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.|d Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA) , Universal Scientific Education and Research Network (USERN) , Tehran , Iran.
authors.forename: Farnaz
authors.initials: F
authors.lastname: Najmi Varzaneh
authors.affiliation: b Molecular Immunology Research Center; Department of Immunology, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.|d Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA) , Universal Scientific Education and Research Network (USERN) , Tehran , Iran.
authors.forename: Behnoud
authors.initials: B
authors.lastname: Baradaran Noveiry
authors.affiliation: b Molecular Immunology Research Center; Department of Immunology, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Sadr
authors.affiliation: a Department of Gastroenterology, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Motamed
authors.affiliation: a Department of Gastroenterology, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Mehri
authors.initials: M
authors.lastname: Najafi
authors.affiliation: a Department of Gastroenterology, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Farahmand
authors.affiliation: b Molecular Immunology Research Center; Department of Immunology, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.|d Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA) , Universal Scientific Education and Research Network (USERN) , Tehran , Iran.|e Research Center for Immunodeficiencies, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
mesh_terms: D016022:Case-Control Studies; D002648:Child; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D019693:Hepatitis, Autoimmune / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics*; D007492:Iran; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C508598:IL4 protein, human; D015847:Interleukin-4
keywords: IL4 gene polymorphisms; SNP; autoimmune hepatitis; cytokines; immunotherapy