title: Effect of age on changes in motor units functional connectivity.
abstract: With age, there is a change in functional connectivity of motor units in muscle. This leads to reduced muscle strength. This study has investigated the effect of age on the changes in the motor unit recruitment by measuring the mutual information between multiple channels of surface electromyogram (sEMG) of biceps brachii muscle. It is hypothesised that with ageing, there is a reduction in number of motor units, which can lead to an increase in the dependency of remaining motor units. This increase can be observed in the mutual information between the multiple channels of the muscle activity. Two channels of sEMG were recorded during the maximum level of isometric contraction. 28 healthy subjects (Young: age range 20-35years and Old: age range - 60-70years) participated in the experiments. The normalized mutual information (NMI), a measure of dependency factor, was computed for the sEMG recordings. Statistical analysis was performed to test the effect of age on NMI. The results show that the NMI among the older cohort was significantly higher when compared with the young adults.
authors.forename: Sridhar P
authors.initials: SP
authors.lastname: Arjunan
authors.forename: Dinesh
authors.initials: D
authors.lastname: Kumar
mesh_terms: D000328:Adult; D000368:Aged; D001132:Arm; D004576:Electromyography; D006801:Humans; D007537:Isometric Contraction; D008875:Middle Aged; D009046:Motor Neurons; D009119:Muscle Contraction; D018482:Muscle, Skeletal; D011999:Recruitment, Neurophysiological; D055815:Young Adult