title: [Factors influencing the clinical pregnancy rate following intrauterine insemination].
abstract: OBJECTIVE
  To investigate the factors that affect the clinical pregnancy rate after intrauterine insemination (IUI).
  
  
  METHODS
  We retrospectively analyzed the clinical data of 611 IUI cycles and analyzed the relationship of the clinical pregnancy rate after IUI with the female age, infertility duration, type of infertility, cycle number, cycle protocol, thickness and type of endometrium, and semen parameters before processing.
  
  
  RESULTS
  The clinical pregnancy rate was significantly higher in the ovulation induction than in the natural ovulation cycles (23.03% vs 11.03%, P < 0.01), but lower in the 4th cycle and above than in the 1st, 2nd, and 3rd cycles (2.04% vs 21.30%, 18.13%, and 12.67%, P < 0.01). Marked decreases were found in the clinical pregnancy rate in the females aged ≥ 40 years and the cases with pre-processing total progressively motile sperm count (TPMSC) < 10 x 10(6), progressive motile sperm < 20%, or morphologically normal sperm < 2% (all P < 0.05). Logistic regression analysis revealed the cycle protocol, cycle number, and percentage of progressively motile sperm as three predictive variables affecting the clinical pregnancy rate after IUI (P < 0.05).
  
  
  CONCLUSIONS
  The cycle protocol, cycle number, percentage of progressively motile sperm, female age, TPMSC, and sperm morphology are the main factors affecting the clinical pregnancy rate following IUI, while infertility duration, type of infertility, and thickness and type of endometrium exert little influence.
authors.forename: Wen-jing
authors.initials: WJ
authors.lastname: Liu
authors.forename: Wen-tao
authors.initials: WT
authors.lastname: Li
authors.forename: Rong-ling
authors.initials: RL
authors.lastname: Zhang
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Gao
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Yue-mei
authors.initials: YM
authors.lastname: Li
mesh_terms: D000328:Adult; D000367:Age Factors; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility; D007315:Insemination, Artificial; D008297:Male; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012661:Semen; D013076:Sperm Count; D013081:Sperm Motility