title: Inorganic Phosphate and Sulfate Transport in S. cerevisiae.
abstract: Inorganic ions such as phosphate and sulfate are essential macronutrients required for a broad spectrum of cellular functions and their regulation. In a constantly fluctuating environment microorganisms have for their survival developed specific nutrient sensing and transport systems ensuring that the cellular nutrient needs are met. This chapter focuses on the S. cerevisiae plasma membrane localized transporters, of which some are strongly induced under conditions of nutrient scarcity and facilitate the active uptake of inorganic phosphate and sulfate. Recent advances in studying the properties of the high-affinity phosphate and sulfate transporters by means of site-directed mutagenesis have provided further insight into the molecular mechanisms contributing to substrate selectivity and transporter functionality of this important class of membrane transporters.
authors.affiliation: Department of Chemistry and Biomedical Sciences, Centre for Biomaterials Chemistry, Linnaeus University, 391 82, Kalmar, Sweden. dieter.samyn@lnu.se.
authors.forename: D R
authors.initials: DR
authors.lastname: Samyn
authors.affiliation: Department of Chemistry and Biomedical Sciences, Centre for Biomaterials Chemistry, Linnaeus University, 391 82, Kalmar, Sweden.
authors.forename: B L
authors.initials: BL
authors.lastname: Persson
mesh_terms: D027321:Anion Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D017136:Ion Transport; D016297:Mutagenesis, Site-Directed; D010710:Phosphates / Q000378:metabolism; D028081:Proton-Phosphate Symporters / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D050611:Sodium-Phosphate Cotransporter Proteins, Type III / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D000076988:Sulfate Transporters; D013431:Sulfates / Q000378:metabolism
chemical_list: D027321:Anion Transport Proteins; C105495:PHO84 protein, S cerevisiae; C493567:PHO89 protein, S cerevisiae; D010710:Phosphates; D028081:Proton-Phosphate Symporters; C094656:SUL1 protein, S cerevisiae; C105781:SUL2 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D050611:Sodium-Phosphate Cotransporter Proteins, Type III; D000076988:Sulfate Transporters; D013431:Sulfates
keywords: Phosphate; Regulation; S. cerevisiae; Sulfate; Transport