title: G-395A polymorphism in the promoter region of the KLOTHO gene associates with reduced cognitive impairment among the oldest old.
abstract: This study aimed to examine the possible association between G-395A polymorphism in the promoter region of the KLOTHO gene and cognitive impairment among Chinese nonagenarians and centenarians. This study is a secondary analysis of the Project of Longevity and Aging in Dujiangyan (PLAD) study. Community-dwelling Chinese people aged 90 years or older were included. G-395A (rs1207568) genotyping in the promoter region of the KLOTHO gene was performed using the TaqMan allelic discrimination assay. Cognitive function was assessed with the mini-mental status examination (MMSE). A total of 706 participants (68.0 % female; mean age 93.5 ± 3.6 years) were included. The KLOTHO G-395A polymorphism genotype frequencies for the whole sample were 2.0 % AA, 30.3 % GA, and 67.7 % GG. The GG genotype frequencies for the cognitive impairment and control groups were 70.2 and 62.7 %, respectively. Cognitive impairment prevalence was significantly lower in the GA+AA group than in the GG genotype group (61.4 vs. 69.0 %, p = 0.044). GA+AA genotype subjects had a significantly lower risk of cognitive impairment (odds ratio 0.66; 95 % confidence interval 0.44 to 0.98) than GG genotype individuals after adjusting for age, gender, and other relevant risk factors. KLOTHO G-395A polymorphism associates with reduced cognitive impairment in a sample of Chinese nonagenarians and centenarians.
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Qiukui
authors.initials: Q
authors.lastname: Hao
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Ding
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Langli
authors.initials: L
authors.lastname: Gao
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China. yangmier@gmail.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Birong
authors.initials: B
authors.lastname: Dong
mesh_terms: D000369:Aged, 80 and over; D000375:Aging; D002681:China / Q000453:epidemiology; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D004247:DNA / Q000235:genetics*; D005260:Female; D005838:Genotype; D005966:Glucuronidase / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D000090265:Klotho Proteins; D008136:Longevity / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D015995:Prevalence; D011401:Promoter Regions, Genetic; D012307:Risk Factors
chemical_list: D004247:DNA; D005966:Glucuronidase; D000090265:Klotho Proteins
keywords: Cognitive impairment; KLOTHO gene; Single nucleotide polymorphism