title: Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC).
abstract: A novel functionally-graded hybrid (FGHY) scaffold was designed and developed with a load-bearing structure represented by a PU foam loaded with a graded composition of CaPs (biomimetic component) and pectin gel as cell carrier. hPDC populations encapsulated in pectin gels and injected into the FGHY scaffolds demonstrated the ability to differentiate toward the osteogenic lineage. The ability of these biomimetic hybrid scaffolds to stimulate cell adhesion and proliferation and to support differentiation of hPDCs make these scaffolds excellent candidates for an use in bone regeneration.
authors.forename: Silvia
authors.initials: S
authors.lastname: Farè
authors.forename: Serena
authors.initials: S
authors.lastname: Bertoldi
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Meskinfam
authors.forename: Valentina
authors.initials: V
authors.lastname: Spoldi
authors.forename: M Cristina
authors.initials: MC
authors.lastname: Tanzi
authors.forename: Ornella
authors.initials: O
authors.lastname: Parolini
mesh_terms: D032701:Biomimetics / Q000379:methods*; D002448:Cell Adhesion; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D010012:Osteogenesis; D010920:Placenta / Q000166:cytology*; D011140:Polyurethanes / Q000737:chemistry; D011247:Pregnancy; D013499:Surface Properties; D054457:Tissue Scaffolds / Q000737:chemistry*; D016474:Weight-Bearing
chemical_list: D011140:Polyurethanes