title: Nanoparticle delivery of sterically hindered platinum(IV) prodrugs shows 100 times higher potency than that of cisplatin upon light activation.
abstract: The introduction of a sterically hindered pyridine ligand to a photosensitive platinum(iv) drug for drug delivery resulted in a >100 fold increase in effectiveness compared to the gold standard, cisplatin.
authors.affiliation: Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 People's Republic of China. zmhtiger@yeah.net and Shanghai Minimally Invasive Surgery Center, Shanghai, 200025 P. R. China.
authors.forename: Haiqin
authors.initials: H
authors.lastname: Song
authors.affiliation: Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Kang
authors.affiliation: Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 People's Republic of China. zmhtiger@yeah.net and Shanghai Minimally Invasive Surgery Center, Shanghai, 200025 P. R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China. Ruoguqix@gmail.com Lesanyan@gmail.com.
authors.forename: Xiabin
authors.initials: X
authors.lastname: Jing
authors.affiliation: Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
authors.forename: Zehua
authors.initials: Z
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China. Ruoguqix@gmail.com Lesanyan@gmail.com and The University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Lesan
authors.initials: L
authors.lastname: Yan
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China. Ruoguqix@gmail.com Lesanyan@gmail.com and The University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Ruogu
authors.initials: R
authors.lastname: Qi
authors.affiliation: Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 People's Republic of China. zmhtiger@yeah.net and Shanghai Minimally Invasive Surgery Center, Shanghai, 200025 P. R. China.
authors.forename: Minhua
authors.initials: M
authors.lastname: Zheng
mesh_terms: D002945:Cisplatin / Q000008:administration & dosage*; D008027:Light; D053758:Nanoparticles; D017671:Platinum Compounds / Q000008:administration & dosage*; D011355:Prodrugs / Q000008:administration & dosage*
chemical_list: D017671:Platinum Compounds; D011355:Prodrugs; D002945:Cisplatin