title: [Relationship between risk of childhood acute leukemia and children's and parents' lifestyles and household environment exposure].
abstract: OBJECTIVE
  To investigate the association between children's and their parents' lifestyles, household environmental exposures and risk of childhood acute leukemia (AL).
  
  
  METHODS
  A 1:2 matched case-control study of childhood AL was conducted in Shanghai between April 2011 and January 2014. The study enrolled 66 cases aged < 15, diagnosed with AL and 132 controls matched by age, gender and residence. All of the controls had no hematological diseases or previous history of malignancy. Children who had been adopted and had congenital genetic syndromes such as Down's syndrome or a positive HIV test result were not eligible as either cases or controls. Information was obtained from standardized face-to-face interviews of their parents/guardians with detailed questions on demographic characteristics, lifestyle, and household environment. Conditional logistic regression models were used to analyze effecting factors of childhood AL, odds ratios (OR) and their 95% confidence intervals (CI) were calculated.
  
  
  RESULTS
  Among 198 cases, 66 cases were aged (5.0 ± 3.7) years old, and 132 controls were aged (6.0 ± 3.8) years old (t = 0.48, P = 0.523). The paternal drink frequencies of cases and controls were 57.6% (38/66), and 31.1% (41/132), respectively (χ² = 4.91, P = 0.027). And the frequencies of household insecticides usage in the last year in the two groups were 78.8% (52/66), and 65.2% (86/132) (χ² = 3.87, P = 0.049). Chemical exposure during childhood (OR = 4.76, 95% CI: 1.34-16.89), maternal exposure to chemicals (OR = 4.51, 95% CI: 1.65-12.33), household insecticides use during 0-3 years of child (OR = 2.90, 95% CI: 1.31-6.39), and renovating after their children's birth (OR = 3.12, 95% CI: 1.26-7.74) were associated with an increased risk of childhood AL and these differences between the cases and the controls have statistical significance. Besides, we found that frequent contaction with other children during 0-3 years old (OR = 0.32, 95% CI: 0.15-0.69) and ventilation during sleeping in summer (OR = 0.43, 95% CI: 0.18-0.98) were associated with a decreased risk of childhood AL.
  
  
  CONCLUSIONS
  Our results support the association between children's and their parents' lifestyles, household environmental exposures and childhood AL.
authors.affiliation: Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Didi
authors.initials: D
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
authors.forename: Rong
authors.initials: R
authors.lastname: Shi
authors.forename: Xiaojin
authors.initials: X
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Hu
authors.forename: Xiaofan
authors.initials: X
authors.lastname: Ji
authors.forename: Kaiyi
authors.initials: K
authors.lastname: Han
authors.forename: Shiyao
authors.initials: S
authors.lastname: Hu
authors.forename: Shuqian
authors.initials: S
authors.lastname: Mao
authors.forename: Jingyi
authors.initials: J
authors.lastname: Feng
authors.affiliation: Email: gaoyu_ciel@sjtu.edu.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000208:Acute Disease; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007306:Insecticides; D007938:Leukemia / Q000453:epidemiology*; D008019:Life Style; D016015:Logistic Models; D018811:Maternal Exposure; D009369:Neoplasms; D016017:Odds Ratio; D010290:Parents; D012307:Risk Factors
chemical_list: D007306:Insecticides