title: [Research progress on ubiquitin-specific protease in antiviral immunity].
abstract: Ubiquitin-specific protease(USP), which belongs to cysteine protease, is an important member of the deubiquitinating enzyme family(DUB). USP plays an important role in the immune response against viral infections, in which it can regulate the production of type I interferon through various ways to initiate or weaken the antiviral immune response. USP2b, USP3, USP18, USP25, UL36USP and HAUSP play a role of antivirus; while USP4, USP13, USP15 and USP17 negatively regulate antiviral immune response. In this article we review the recent progress on roles of USP family in antiviral immune response.
authors.affiliation: Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Hui-hui
authors.initials: HH
authors.lastname: Zhu
authors.affiliation: Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Xi-bao
authors.initials: XB
authors.lastname: Zhao
authors.affiliation: Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Hu
authors.affiliation: Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Wei-lin
authors.initials: WL
authors.lastname: Chen
mesh_terms: D006801:Humans; D007370:Interferon Type I / Q000276:immunology; D064570:Ubiquitin-Specific Proteases / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
chemical_list: D007370:Interferon Type I; D064570:Ubiquitin-Specific Proteases