title: Daptomycin-resistant Staphylococcus pettenkoferi of human origin.
abstract: The importance of nosocomial infections caused by coagulase-negative staphylococci is constantly growing. The threat primarily affects immunocompromised patients, the elderly and neonates, particularly after invasive surgery. The problem is fundamentally exacerbated by expanding antibacterial drug resistance. A case report is presented of an 86-year-old patient who underwent a ruptured abdominal aortic aneurysm surgery and developed septicaemia upon surgical wound infection. The causal agent was likely a carbapenem-resistant Klebsiella pneumoniae, however, daptomycin-resistant Staphylococcus pettenkoferi was identified in blood cultures in the absence of daptomycin treatment. To the authors' knowledge, the case study presented is the first published episode of daptomycin-resistant S. pettenkoferi strain.
authors.affiliation: Clinical Microbiology and Virology, Spirito Santo Hospital, Pescara, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Savini
authors.affiliation: Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
authors.forename: Maja
authors.initials: M
authors.lastname: Kosecka
authors.affiliation: LGC Ltd, Newmarket Rd, Fordham, Cambridgeshire, United Kingdom.
authors.forename: Ed
authors.initials: E
authors.lastname: Siegwart
authors.affiliation: Clinical Microbiology and Virology, Spirito Santo Hospital, Pescara, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Marrollo
authors.affiliation: Clinical Microbiology and Virology, Spirito Santo Hospital, Pescara, Italy.
authors.forename: Ennio
authors.initials: E
authors.lastname: Polilli
authors.affiliation: Epidemiological Office, Spirito Santo Hospital, Pescara, Italy.
authors.forename: Dalia
authors.initials: D
authors.lastname: Palmieri
authors.affiliation: Clinical Microbiology and Virology, Spirito Santo Hospital, Pescara, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Fazii
authors.affiliation: Laboratory of Microbiology, IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Carretto
authors.affiliation: Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Międzobrodzki
authors.affiliation: Department of Analytical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
authors.forename: Michal
authors.initials: M
authors.lastname: Bukowski
mesh_terms: D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017576:Daptomycin / Q000494:pharmacology* / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D017809:Fatal Outcome; D005798:Genes, Bacterial; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D012150:Polymorphism, Restriction Fragment Length; D012772:Shock, Septic / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D013210:Staphylococcus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin