title: Ultrasound biomicroscopic study of the effects of topical latanoprost on the anterior segment and ciliary body thickness in dogs.
abstract: OBJECTIVE
  The goal of this study was to evaluate the effects of topical latanoprost on the anterior segment and ciliary body using ultrasound biomicroscopy (UBM) in dogs.
  
  
  METHODS
  This study included six eyes of six clinically normal beagles.
  
  
  METHODS
  UBM scans were performed on six sedated dogs before and 2 h after topical latanoprost instillation. From the next day on, latanoprost was topically applied twice daily for 7 days. After 1 week of instillation, the UBM scans were repeated. The ciliary body thickness (CBT) and the anterior segment parameters, including the iridocorneal angle (ICA), the width of the ciliary cleft (CC) entry, the length of the CC, and the width of the mid-CC, were measured.
  
  
  RESULTS
  The topical latanoprost decreased the ICA and CC entry width and increased the mid-CC width without any significant alterations in the CC length. There were time-dependent alterations in the CBT: a reduction in the CBT after 2 h of instillation and rebound thickening after 1 week of instillation.
  
  
  CONCLUSIONS
  The topical latanoprost widened the ciliary cleft despite the narrowing of the ICA and CC entry. Time-dependent alterations in the CBT were demonstrated by the UBM and might be a reflection of the mechanism of the uveoscleral outflow enhancement induced by the topical latanoprost.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.
authors.forename: Sangwan
authors.initials: S
authors.lastname: Park
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.
authors.forename: Seonmi
authors.initials: S
authors.lastname: Kang
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.
authors.forename: Euiri
authors.initials: E
authors.lastname: Lee
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.
authors.forename: Jiyoon
authors.initials: J
authors.lastname: Kwak
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.
authors.forename: Eunjin
authors.initials: E
authors.lastname: Park
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea.
authors.forename: Jaegook
authors.initials: J
authors.lastname: Lim
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea. kmseo@snu.ac.kr.
authors.forename: Kangmoon
authors.initials: K
authors.lastname: Seo
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects*; D002924:Ciliary Body / Q000187:drug effects*; D004285:Dogs; D000077338:Latanoprost; D033401:Microscopy, Acoustic; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*
chemical_list: D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost
keywords: canine; ciliary body thickness; ciliary cleft; latanoprost; ultrasound biomicroscopy; uveoscleral outflow