title: The cytotoxic activity of Ziziphus Jujube on cervical cancer cells: In Vitro study.
abstract: Recently, there are tendency to use natural products such as Ziziphus Jujube (Jujube) as therapeutic agents for cancer. Understanding the molecular mechanisms of anti-cancer effects of Jujube may improve the current therapeutic strategies against cervical cancer. Our MTT data showed a significant dose- and time-dependent inhibition of OV-2008 cell proliferation following Jujube administration. Moreover, qRT-PCR analyses significantly revealed the suppression of cyclin D1 and the enhancement of P53, P21 and P27 expression in treated cells. These results suggest that the herb exerts a cytotoxic effect on cervical cancer cells through alternation of the expression of the genes that are involved in regulation of cell cycle.
authors.affiliation: Birjand University of Medical Sciences Cellular & Molecular Research Center Birjand Iran.
authors.forename: R
authors.initials: R
authors.lastname: Hoshyar
authors.affiliation: Birjand University of Medical Sciences Cellular & Molecular Research Center Birjand Iran.
authors.forename: S
authors.initials: S
authors.lastname: Jamali
authors.affiliation: Birjand University of Medical Sciences Department of Immunology, Faculty of Medicine Birjand Iran.
authors.forename: M
authors.initials: M
authors.lastname: Fereidouni
authors.affiliation: Birjand University of Medical Sciences Cellular & Molecular Research Center Birjand Iran mohrabe@yahoo.com.
authors.forename: M R
authors.initials: MR
authors.lastname: Abedini
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects* / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002584:Cervix Uteri / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D019938:Cyclin D1 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005638:Fruit / Q000737:chemistry; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D031957:Ziziphus / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C530104:CCND1 protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D010936:Plant Extracts; D016159:Tumor Suppressor Protein p53; D019938:Cyclin D1; D050760:Cyclin-Dependent Kinase Inhibitor p27