title: Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs.
abstract: BACKGROUND
  Local anesthetic infusion techniques have been reported to reduce opiate requirements and pain scores following different kinds of surgery, including orthopedic surgery, inguinal hernia, and Cesarean surgery in women.
  
  
  METHODS
  PRF-108 and PRF-110 formulations were applied to the wound space in an incisional model in pigs to test the hypothesis that these formulations have better and longer analgesic effects than the commercially available ropivacaine solution (Naropin(®), AstraZeneca).
  
  
  RESULTS
  The data show significantly better analgesic activity with PRF-108 and PRF-110 compared to ropivacaine. The duration of the analgesic efficacy of PRF-108 and PRF-110 was at least five times longer than that was measured following treatment with ropivacaine. The data further suggest that active clearance from the injection site (the wound) is much slower for PRF-108 and PRF-110 than for the commercial ropivacaine solution.
  
  
  CONCLUSIONS
  Assessing the local concentration of PRF compounds and commercially available ropivacaine solution suggests that active clearance from the injection site (the wound) is much slower for PRF-108 and PRF-110 than for ropivacaine.
  
  
  BACKGROUND
  PainReform.
authors.affiliation: The Neufeld Cardiac Research Institute and Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Castel
authors.affiliation: PainReform, c/o Medica VP, Herzeliya, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Naveh
authors.affiliation: PainReform, c/o Medica VP, Herzeliya, Israel.
authors.forename: Arnon
authors.initials: A
authors.lastname: Aharon
authors.affiliation: Lahav Research Institute, Kibutz Lahav, Negev, Israel.
authors.forename: Ofer
authors.initials: O
authors.lastname: Doron
authors.affiliation: Neurology Division, MD Biosciences, Ness Ziona, Israel. sigal@mdbiosciences.com.
authors.forename: Sigal
authors.initials: S
authors.lastname: Meilin
keywords: Incision; PRF-108; PRF-110; Pain; Pig; Ropivacain; Surgery