title: The effect of low-sodium dialysate on ambulatory blood pressure measurement parameters in patients undergoing hemodialysis.
abstract: BACKGROUND
  End stage renal disease is related to increased cardiovascular mortality and morbidity. Hypertension is an important risk factor for cardiovascular disorder among hemodialysis (HD) patients. The aim of this study was to investigate the effect of low-sodium dialysate on the systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels detected by ambulatory BP monitoring (ABPM) and interdialytic weight gain (IDWG) in patients undergoing sustained HD treatment.
  
  
  METHODS
  The study included 46 patients who had creatinine clearance levels less than 10 mL/min/1.73 m(2) and had been on chronic HD treatment for at least 1 year. After the enrollment stage, the patients were allocated low-sodium dialysate or standard sodium dialysate for 6 months via computer-generated randomization.
  
  
  RESULTS
  Twenty-four hour SBP, daytime SBP, nighttime SBP, and nighttime DBP were significantly decreased in the low-sodium dialysate group (P<0.05). No significant reduction was observed in both groups in terms of 24-hour DBP and daytime DBP (P=NS). No difference was found in the standard sodium dialysate group in terms of ABPM. Furthermore, IDWG was found to be significantly decreased in the low-sodium dialysate group after 6 months (P<0.001).
  
  
  CONCLUSIONS
  The study revealed that low-sodium dialysate leads to a decrease in ABPM parameters including 24-hour SBP, daytime SBP, nighttime SBP, and nighttime DBP and it also reduces the number of antihypertensive drugs used and IDWG.
authors.affiliation: Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Akdag
authors.affiliation: Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Aytac
authors.initials: A
authors.lastname: Akyol
authors.affiliation: Department of Cardiology, Rize Kackar Government Hospital, Rize, Turkey.
authors.forename: Huseyin Altug
authors.initials: HA
authors.lastname: Cakmak
authors.affiliation: Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Training Hospital, Istanbul, Turkey.
authors.forename: Aydin Rodi
authors.initials: AR
authors.lastname: Tosu
authors.affiliation: Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Muntecep
authors.initials: M
authors.lastname: Asker
authors.affiliation: Department of Cardiology, Samsun Education and Training Hospital, Samsun, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yaman
authors.affiliation: Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Naci
authors.initials: N
authors.lastname: Babat
authors.affiliation: Department of Nephrology, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Soyoral
authors.affiliation: Department of Anesthesiology and Reanimation, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Muhammed Bilal
authors.initials: MB
authors.lastname: Cegin
authors.affiliation: Department of Cardiovascular Surgery, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Ali Kemal
authors.initials: AK
authors.lastname: Gur
authors.affiliation: Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: Gumrukcuoglu
keywords: hemodialysis; hypertension; sodium dialysate