title: nMET, A New Target in Recurrent Cancer.
abstract: Membranous Met is classically identified with its role in cancer metastases, while nuclear Met is associated with a more invasive, aggressive and proliferative form of cancer. Full-length Met or N-terminal transmembrane domain cleaved Met can translocate into nucleus in a cell growth and pH dependent but both ligand-dependent (full length Met) and -independent (cleaved Met) manner. nMET may play greater essential roles in cancer recurrence than membranous Met. For example, in prostate cancer, it has been found that androgen receptor (AR) may inhibit the expression of membranous Met so anti-androgen based prostate cancer therapy may promote the expression of nuclear Met (nMET). We recently found a novel nMET/SOX9/ β-Catenin/AR pathway in relapsed prostate cancer which may contribute to the formation of the feedback loop of AR reactivation via MET/nMET. Emerging evidence suggests the possibility of nMET as a prognostic marker in relapsed cancer. This review summarizes recent findings about nMET and its unique role in recurrent cancer.
authors.affiliation: Department of Biology, Nazarbayev University, School of Science and Technology, 53 Kabanbay Batyr Ave., Astana, 010000, Republic of Kazakhstan. xieautumnus@yahoo.com.
authors.forename: Yingqiu
authors.initials: Y
authors.lastname: Xie
authors.forename: Sholpan
authors.initials: S
authors.lastname: Istayeva
authors.forename: Zhanlin
authors.initials: Z
authors.lastname: Chen
authors.forename: Tursonjan
authors.initials: T
authors.lastname: Tokay
authors.forename: Zhaxybay
authors.initials: Z
authors.lastname: Zhumadilov
authors.forename: Denglong
authors.initials: D
authors.lastname: Wu
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Hortelano
authors.forename: Jinfu
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D009364:Neoplasm Recurrence, Local / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D011379:Prognosis; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D014408:Biomarkers, Tumor; D008565:Membrane Proteins; D019859:Proto-Oncogene Proteins c-met