title: Dietary Total Isoflavone Intake Is Associated With Lower Systolic Blood Pressure: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.
abstract: The effect of dietary isoflavone intake on systolic blood pressure (SBP) has not been studied in a large community-based cohort inclusive of African Americans. The authors analyzed data from the year 20 examination of the Coronary Artery Risk Development in Young Adults (CARDIA) study, including medical history, physical examination, and dietary intake surveys for 3142 participants. Multivariable linear regression models controlled for age, sex, body mass index, smoking, physical activity, and intakes of alcohol and total energy. Effect modification by race was tested. Overall, patients with hypertension had a lower daily intake of total dietary isoflavones (2.2±5.2 mg/d vs 4.1±11.7 mg/d; P<.001). In fully adjusted models, the highest quartile of dietary isoflavone intake was associated with a 4.4 mm Hg lower SBP on average compared with SBP for the lowest quartile. The relationship between dietary isoflavone intake and SBP was more pronounced among African Americans compared with Caucasians (P for interaction <.001). Greater dietary intake of isoflavones was independently associated with a lower SBP.
authors.affiliation: Department of Medicine, Hofstra North Shore-LIJ School of Medicine, Manhasset, NY.
authors.forename: Safiya I
authors.initials: SI
authors.lastname: Richardson
authors.affiliation: Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.
authors.forename: Lyn M
authors.initials: LM
authors.lastname: Steffen
authors.affiliation: Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
authors.forename: Katrina
authors.initials: K
authors.lastname: Swett
authors.affiliation: Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
authors.forename: Che
authors.initials: C
authors.lastname: Smith
authors.affiliation: University of Pittsburgh School of Nursing, Pittsburgh, PA.
authors.forename: Lora
authors.initials: L
authors.lastname: Burke
authors.affiliation: Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL.
authors.forename: James M
authors.initials: JM
authors.lastname: Shikany
authors.affiliation: Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
authors.forename: Carlos J
authors.identifier: 0000-0003-0860-9008
authors.initials: CJ
authors.lastname: Rodriguez
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D001794:Blood Pressure / Q000187:drug effects*; D003324:Coronary Artery Disease / Q000517:prevention & control*; D003430:Cross-Sectional Studies; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D006973:Hypertension / Q000178:diet therapy* / Q000208:ethnology / Q000503:physiopathology; D007529:Isoflavones / Q000032:analysis* / Q000494:pharmacology; D008297:Male; D012044:Regression Analysis; D044465:White People / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D007529:Isoflavones