title: Association study of hsa-mir-603 rs11014002 polymorphism and risk of breast cancer in a sample of Iranian population.
abstract: Accumulated evidence have proposed that single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) are connected to breast cancer (BC) risk. We have done a case-control study with 258 BC patients and 209 control women to examine the potential association of Hsa-mir-603 rs11014002 C>T polymorphisms with BC susceptibility. The polymorphisms were genotyped by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. Our findings showed that the rs11014002 C>T variant was not associated with an increased risk of BC in codominant (OR=0.67, 95%CI=0.42-1.08, P=0.121, CT vs CC; and OR=0.18, 95%CI=0.02-1.67, P=0.170, TT vs CC), dominant (OR=0.64, 95%CI=0.41-1.01, P=0.062, CT+TT vs CC), and recessive (OR=0.20, 95%CI=0.02-1.81, P=0.178, TT vs CC+CT) inheritance models tested. While, the T allele significantly decreased the risk of BC (OR= 0.63; 95% CI =0.41-0.95; P=0.032) compared to C allele. In conclusion, the findings indicated that Mir603 rs11014002 T allele might contribute to decrease the risk of BC in a sample of Iranian population. Further studies with larger sample sizes and different ethnicities are warranted to confirm our findings.
authors.affiliation: Zahedan University of Medical Sciences Cellular and Molecular Research Center Zahedan Iran mhd.hashemi@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Hashemi
authors.affiliation: Zahedan University of Medical Sciences Department of Clinical Biochemistry, School of Medicine Zahedan Iran.
authors.forename: S
authors.initials: S
authors.lastname: Sanaei
authors.affiliation: Zahedan University of Medical Sciences Department of Internal Medicine, School of Medicine Zahedan Iran.
authors.forename: M A
authors.initials: MA
authors.lastname: Mashhadi
authors.affiliation: Zahedan University of Medical Sciences Department of Internal Medicine, School of Medicine Zahedan Iran.
authors.forename: S M
authors.initials: SM
authors.lastname: Hashemi
authors.affiliation: Zahedan University of Medical Sciences Genetic of non&mdash;communicable disease research Center Zahedan Iran.
authors.forename: M
authors.initials: M
authors.lastname: Taheri
authors.affiliation: University of Manitoba Department of Human Anatomy and Cell Science, College of Medicine, Faculty of Health Sciences Winnipeg Canada.
authors.forename: S
authors.initials: S
authors.lastname: Ghavami
mesh_terms: D000328:Adult; D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D008957:Models, Genetic; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: C000597759:MIRN603 microRNA, human; D035683:MicroRNAs