title: Is migraine a consequence of a loss of neurohormonal and metabolic integrity? A new hypothesis.
abstract: OBJECTIVE
  In 2002 we suggested a new hypothesis of migraine. This hypothesis implies that migraine is a consequence of a loss of neurohormonal and metabolic integrity. The goal of this clinical analysis is to present the evaluation of the effect of a multimodal treatment program in migraine management.
  
  
  METHODS
  We evaluated 30 patients ages 16-66 with migraine who were treated with a multimodal treatment program. All patients received a complex program which included: hormonorestorative therapy (HT) with bio-identical hormones; correction of balance between sympathetic and parasympathetic systems and simultaneously calcium/magnesium balance; "resetting" the pineal gland; improvement of intestinal absorption through restoration of normal intestinal flora, and a cleanse from parasitic infestation (if necessary). Serum levels of total cholesterol (TC), pregnenolone, dehydroepiandrosterone sulfate (DHEAS), progesterone, total estrogen, and total testosterone were determined,
  
  
  RESULTS
  All patients responded to this regimen. We do not have patients who still have migraine after they started to use this program. Laboratory finding prior to HT showed the significant deficiency in production of all basic steroid hormones (progesterone and pregnenolone production declined the most). Concurrent symptoms such as fibromyalgia, insomnia, depression, gastrointestinal disorders, and fatigue had disappeared. Total cholesterol completely normalized in 22 (91.7%) patients. No adverse effects or complications related to this program were registered.
  
  
  CONCLUSIONS
  Our findings support the hypothesis that migraine is a consequence of a loss of neurohormonal and metabolic integrity, and that migraine can be managed by a multimodal approach.
authors.affiliation: Dzugan Institute of Restorative Medicine, Deerfield Beach, FL, USA.
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Dzugan
authors.affiliation: Dzugan Institute of Restorative Medicine, Deerfield Beach, FL, USA.
authors.forename: Konstantine S
authors.initials: KS
authors.lastname: Dzugan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000728:Androgens / Q000627:therapeutic use*; D003687:Dehydroepiandrosterone / Q000627:therapeutic use; D004958:Estradiol / Q000627:therapeutic use; D004964:Estriol / Q000627:therapeutic use; D004967:Estrogens / Q000627:therapeutic use*; D004970:Estrone / Q000627:therapeutic use; D005260:Female; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D011284:Pregnenolone / Q000627:therapeutic use; D011374:Progesterone / Q000627:therapeutic use; D011372:Progestins / Q000627:therapeutic use*; D013739:Testosterone / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000728:Androgens; D004967:Estrogens; D011372:Progestins; D004970:Estrone; D013739:Testosterone; D003687:Dehydroepiandrosterone; D011374:Progesterone; D004958:Estradiol; D011284:Pregnenolone; D004964:Estriol