title: Protein-protein interactions in DNA mismatch repair.
abstract: The principal DNA mismatch repair proteins MutS and MutL are versatile enzymes that couple DNA mismatch or damage recognition to other cellular processes. Besides interaction with their DNA substrates this involves transient interactions with other proteins which is triggered by the DNA mismatch or damage and controlled by conformational changes. Both MutS and MutL proteins have ATPase activity, which adds another level to control their activity and interactions with DNA substrates and other proteins. Here we focus on the protein-protein interactions, protein interaction sites and the different levels of structural knowledge about the protein complexes formed with MutS and MutL during the mismatch repair reaction.
authors.affiliation: Institute for Biochemistry FB 08, Justus Liebig University, Heinrich-Buff-Ring 17, D-35392 Giessen, Germany. Electronic address: peter.friedhoff@chemie.bio.uni-giessen.de.
authors.forename: Peter
authors.initials: P
authors.lastname: Friedhoff
authors.affiliation: Institute for Biochemistry FB 08, Justus Liebig University, Heinrich-Buff-Ring 17, D-35392 Giessen, Germany.
authors.forename: Pingping
authors.initials: P
authors.lastname: Li
authors.affiliation: Institute for Biochemistry FB 08, Justus Liebig University, Heinrich-Buff-Ring 17, D-35392 Giessen, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Gotthardt
mesh_terms: D000818:Animals; D053843:DNA Mismatch Repair; D006801:Humans; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000378:metabolism; D011485:Protein Binding; D025941:Protein Interaction Mapping; D055503:Protein Multimerization
chemical_list: D046912:Multiprotein Complexes