title: Influence of White-Coat Hypertension on Left Ventricular Deformation 2- and 3-Dimensional Speckle Tracking Study.
abstract: We sought to compare left ventricular deformation in subjects with white-coat hypertension to normotensive and sustained hypertensive patients. This cross-sectional study included 139 untreated subjects who underwent 24-hour ambulatory blood pressure monitoring and completed 2- and 3-dimensional examination. Two-dimensional left ventricular multilayer strain analysis was also performed. White-coat hypertension was diagnosed if clinical blood pressure was elevated and 24-hour blood pressure was normal. Our results showed that left ventricular longitudinal and circumferential strains gradually decreased from normotensive controls across subjects with white-coat hypertension to sustained hypertensive group. Two- and 3-dimensional left ventricular radial strain, as well as 3-dimensional area strain, was not different between groups. Two-dimensional left ventricular longitudinal and circumferential strains of subendocardial and mid-myocardial layers gradually decreased from normotensive control to sustained hypertensive group. Longitudinal and circumferential strains of subepicardial layer did not differ between the observed groups. We concluded that white-coat hypertension significantly affects left ventricular deformation assessed by 2-dimensional traditional strain, multilayer strain, and 3-dimensional strain.
authors.affiliation: From the Cardiology Department, University Clinical Hospital Center "Dr Dragisa Misovic-Dedinje", Belgrade, Serbia (M.T., I.I., V.C., V.K.); Department of Cardiology, Faculty of Medicine, Belgrade, Serbia (M.T., B.I., V.C.); and Clinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano, Meda, Italy (C.C.). marijana_tadic@hotmail.com.
authors.forename: Marijana
authors.initials: M
authors.lastname: Tadic
authors.affiliation: From the Cardiology Department, University Clinical Hospital Center "Dr Dragisa Misovic-Dedinje", Belgrade, Serbia (M.T., I.I., V.C., V.K.); Department of Cardiology, Faculty of Medicine, Belgrade, Serbia (M.T., B.I., V.C.); and Clinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano, Meda, Italy (C.C.).
authors.forename: Cesare
authors.initials: C
authors.lastname: Cuspidi
authors.affiliation: From the Cardiology Department, University Clinical Hospital Center "Dr Dragisa Misovic-Dedinje", Belgrade, Serbia (M.T., I.I., V.C., V.K.); Department of Cardiology, Faculty of Medicine, Belgrade, Serbia (M.T., B.I., V.C.); and Clinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano, Meda, Italy (C.C.).
authors.forename: Branislava
authors.initials: B
authors.lastname: Ivanovic
authors.affiliation: From the Cardiology Department, University Clinical Hospital Center "Dr Dragisa Misovic-Dedinje", Belgrade, Serbia (M.T., I.I., V.C., V.K.); Department of Cardiology, Faculty of Medicine, Belgrade, Serbia (M.T., B.I., V.C.); and Clinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano, Meda, Italy (C.C.).
authors.forename: Irena
authors.initials: I
authors.lastname: Ilic
authors.affiliation: From the Cardiology Department, University Clinical Hospital Center "Dr Dragisa Misovic-Dedinje", Belgrade, Serbia (M.T., I.I., V.C., V.K.); Department of Cardiology, Faculty of Medicine, Belgrade, Serbia (M.T., B.I., V.C.); and Clinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano, Meda, Italy (C.C.).
authors.forename: Vera
authors.initials: V
authors.lastname: Celic
authors.affiliation: From the Cardiology Department, University Clinical Hospital Center "Dr Dragisa Misovic-Dedinje", Belgrade, Serbia (M.T., I.I., V.C., V.K.); Department of Cardiology, Faculty of Medicine, Belgrade, Serbia (M.T., B.I., V.C.); and Clinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano, Meda, Italy (C.C.).
authors.forename: Vesna
authors.initials: V
authors.lastname: Kocijancic
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D003430:Cross-Sectional Studies; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D059466:White Coat Hypertension / Q000000981:diagnostic imaging* / Q000503:physiopathology
keywords: ambulatory blood pressure monitoring; left ventricle; three-dimensional echocardiography; two-dimensional speckle tracking; white-coat hypertension