title: A trend towards increasing viral load in newly diagnosed HIV-infected inpatients in southeast China.
abstract: Peripheral blood viral load is an important indicator of viral production and clearance. Previous studies have suggested that viral load might predict the rate of decrease in CD4+ cell count and progression to AIDS and death. Here, we conducted a retrospective analysis of the trends in HIV-1 viral load in southeast China. Among inpatients newly diagnosed with HIV infection, we found that viral load has increased over the past decade from 4·20 log10 copies/ml in 2002 to 6·61 log10 copies/ml in 2014, with a mean increase of 0·19 log10 copies/ml each year. However, the CD4+ cell count was stable and insensitive to changes in viral load. Thus, increasing viral load appears to be an emerging trend in newly diagnosed HIV-infected inpatients.
authors.affiliation: Fuzhou Infectious Disease Hospital of Fujian Medical University,Fuzhou,P.R. China.
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Fuzhou Infectious Disease Hospital of Fujian Medical University,Fuzhou,P.R. China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Fuzhou Infectious Disease Hospital of Fujian Medical University,Fuzhou,P.R. China.
authors.forename: A
authors.initials: A
authors.lastname: Huang
authors.affiliation: Fuzhou Infectious Disease Hospital of Fujian Medical University,Fuzhou,P.R. China.
authors.forename: J
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Fuzhou Infectious Disease Hospital of Fujian Medical University,Fuzhou,P.R. China.
authors.forename: D
authors.initials: D
authors.lastname: Wei
authors.affiliation: Fuzhou Infectious Disease Hospital of Fujian Medical University,Fuzhou,P.R. China.
authors.forename: H
authors.initials: H
authors.lastname: Ye
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D002681:China; D005260:Female; D015658:HIV Infections / Q000175:diagnosis* / Q000473:pathology / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D019562:Viral Load
keywords: HIV; increasing trends; viral load