title: Adverse Events in Treating Smear-Positive Tuberculosis Patients in China.
abstract: This study aimed to estimate the adverse events (AE) rate during anti-tuberculosis treatment and to explore AE-related risk factors. New and previously treated smear-positive tuberculosis (TB) cases were enrolled from eight regions in China between April 2009 and October 2010. The AE rate was estimated, and AE risk factors during anti-TB treatment were assessed using Cox proportional models. Among 2091 Chinese subjects with anti-TB treatment, 462 (22.1%, 95% confidence interval (CI), 20.3-23.9) patients developed AE, with liver injury and gastrointestinal reactions constituting the most common AE. Specifically, 9.8% (95% CI, 8.5-11.1) and 6.3% (95% CI, 5.3-7.4) developed liver injuries and gastrointestinal reactions, respectively. We found that AE rate differed by regions, TB knowledge score, symptoms score and smoking status. Liver injuries were associated with age, sex and smoking status; gastrointestinal reactions were associated with education level and symptom score. Improving patients' knowledge on TB could reduce AE rate.
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China. tao_zhang@live.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Clinical Center Office, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China. jdu-sdu@163.com.|Beijing Chest Hospital, Capital Medical University, Beijing 101149, China. jdu-sdu@163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Du
authors.affiliation: National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA 01702-5827, USA. xyin@bu.edu.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Yin
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China. xuefzh@sdu.edu.cn.
authors.forename: Fuzhong
authors.initials: F
authors.lastname: Xue
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China. liu-yx@sdu.edu.cn.
authors.forename: Yanxun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China. runzi_li@hotmail.com.
authors.forename: Runzi
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China. luomadcheng@vip.163.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Luo
authors.affiliation: Clinical Center Office, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China. liliang@tb123.org.|Beijing Chest Hospital, Capital Medical University, Beijing 101149, China. liliang@tb123.org.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China. xjli@sdu.edu.cn.
authors.forename: Xiujun
authors.initials: X
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D005500:Follow-Up Studies; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012307:Risk Factors; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents
keywords: China; adverse events; risk factors; tuberculosis epidemiology