title: Epigenetic modulation of gene expression governs the brain's response to injury.
abstract: Mild stress from ischemia, seizure, hypothermia, or infection can produce a transient neuroprotected state in the brain. In the neuroprotected state, the brain responds differently to a severe stress and sustains less injury. At the genomic level, the response of the neuroprotected brain to a severe stress is characterized by widespread differential regulation of genes with diverse functions. This reprogramming of gene expression observed in the neuroprotected brain in response to a stress is consistent with an epigenetic model of regulation mediated by changes in DNA methylation and histone modification. Here, we summarize our evolving understanding of the molecular basis for endogenous neuroprotection and review recent findings that implicate DNA methylation and protein mediators of histone modification as epigenetic regulators of the brain's response to injury.
authors.affiliation: Translational Stroke Program, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA; Grady Memorial Hospital, Atlanta, GA, USA. Electronic address: rsimon@msm.edu.
authors.forename: Roger P
authors.initials: RP
authors.lastname: Simon
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000235:genetics*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D015870:Gene Expression; D042421:Histone Code; D006801:Humans; D000066829:Neuroprotection; D063146:Polycomb-Group Proteins / Q000235:genetics
chemical_list: D063146:Polycomb-Group Proteins
keywords: DNA methylation; Epigenetic regulation; Ischemia; Neuroprotection; PcG proteins; Seizure