title: Long non-coding RNAs: emerging players in osteosarcoma.
abstract: Osteosarcoma is the most common kind of primary bone tumors with high morbidity in infants and adolescents. While the molecular mechanism of osteosarcoma has gained considerable attention, the mechanisms underlying its initiation and progression remain unclear. Recent studies have discovered that long non-coding RNAs (lncRNAs) play an important role in multiply biological processes including cell development, differentiation, proliferation, invasion, and migration. Deregulated expression of lncRNAs has been found in cancers including osteosarcoma. This review summarized the deregulation and functional role of lncRNAs in osteosarcoma and their potential application for diagnosis and treatment of osteosarcoma.
authors.affiliation: Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. shenjianxiong@medmail.com.cn.
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Shen
mesh_terms: D001859:Bone Neoplasms / Q000209:etiology* / Q000235:genetics; D006801:Humans; D012516:Osteosarcoma / Q000209:etiology* / Q000235:genetics; D062085:RNA, Long Noncoding / Q000032:analysis / Q000502:physiology*
chemical_list: C094335:H19 long non-coding RNA; C557041:MALAT1 long non-coding RNA, human; D062085:RNA, Long Noncoding; C000598536:TUG1 long noncoding RNA, human; C581996:loc285194 LncRNA, human
keywords: Long non-coding RNAs; MALAT1; Osteosarcoma; lncRNAs