title: Expression of DNA methylation genes in secondary progressive multiple sclerosis.
abstract: Multiple sclerosis (MS) is an immunoinflammatory disease of the central nervous system that seems to be influenced by DNA methylation. We sought to explore the expression pattern of genes involved in the control of DNA methylation in Secondary Progressive (SP) MS patients' PBMCs. We have found that SP MS is characterized by a significant upregulation of two genes belonging to the MBD family genes, MBD2 and MBD4, and by a downregulation of TDG and TET3.
authors.affiliation: Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Fagone
authors.affiliation: Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
authors.forename: Katia
authors.initials: K
authors.lastname: Mangano
authors.affiliation: Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Di Marco
authors.affiliation: Laboratory of Cellular and Molecular Biology, University of Bab-Ezzouar, Algiers, Algeria.
authors.forename: Chafia
authors.initials: C
authors.lastname: Touil-Boukoffa
authors.affiliation: High Technology Medical Center, Tbilisi 1st Hospital University Clinic, Tbilisi, Georgia.
authors.forename: Tinatin
authors.initials: T
authors.lastname: Chikovan
authors.affiliation: Department of Internal Medicine, Section of Anatomic Pathology, University of Catania, Milan, Italy.
authors.forename: Santo
authors.initials: S
authors.lastname: Signorelli
authors.affiliation: Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
authors.forename: Giuseppe A G
authors.initials: GA
authors.lastname: Lombardo
authors.affiliation: Department of Neurosciences, Section of Anatomic Pathology, University of Catania, Milan, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Patti
authors.affiliation: Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
authors.forename: Santa
authors.initials: S
authors.lastname: Mammana
authors.affiliation: Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy. Electronic address: ferdinic@unict.it.
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Nicoletti
mesh_terms: D000328:Adult; D019175:DNA Methylation / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins
keywords: DNA methylation; Epigenetics; Multiple sclerosis