title: [Prevalence of gene polymorphisms associated with immune-dependent diseases in the populations of North Eurasia].
abstract: The data on distribution of genetic diversity in gene polymorphisms associated with autoimmune and allergic diseases and with regulation of immunoglobulin E and cytokines levels in 26 populations of the Northern Eurasia is presented. Substantial correlation between the values of average expected heterozygosity by 44 gene polymorphisms with climatic and geographical factors has not been revealed. Clustering of population groups in correspondence with their geographic locations is observed. The degree of gene differentiation among populations and the selective neutrality of gene polymorphisms have been assessed. The results of our work evidence the substantial genetic diversity and differentiation of human populations by studied genes.
authors.affiliation: National Research Tomsk State University, Tomsk, 634050 Russia;|Research Institute for Medical Genetics, Tomsk, 634050 Russia.|anastasia.cherednichenko@medgenetics.ru.
authors.forename: A A
authors.initials: AA
authors.lastname: Cherednichenko
authors.affiliation: National Research Tomsk State University, Tomsk, 634050 Russia;|Research Institute for Medical Genetics, Tomsk, 634050 Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Trifonova
authors.affiliation: National Research Tomsk State University, Tomsk, 634050 Russia;|Research Institute for Medical Genetics, Tomsk, 634050 Russia.
authors.forename: K V
authors.initials: KV
authors.lastname: Vagaitseva
authors.affiliation: Research Institute for Medical Genetics, Tomsk, 634050 Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Bocharova
authors.affiliation: Chiril Draganiuc Institute of Phthisiopulmonology, Chisinau, MD 2025, Republic of Moldova.
authors.forename: A M
authors.initials: AM
authors.lastname: Varzari
authors.affiliation: Analytical Center for Collective Use, Dagestan Scientific Center, Russian Academy of Sciences, Makhachkala, 367001 Russia.|Dagestan Medical Dental Institute, Makhachkala, 367015 Russia.
authors.forename: M O
authors.initials: MO
authors.lastname: Radzhabov
authors.affiliation: National Research Tomsk State University, Tomsk, 634050 Russia;|Research Institute for Medical Genetics, Tomsk, 634050 Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Stepanov
mesh_terms: D016207:Cytokines / Q000235:genetics; D017753:Ecosystem; D005787:Gene Frequency; D006801:Humans; D007154:Immune System Diseases / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D007073:Immunoglobulin E / Q000235:genetics; D011110:Polymorphism, Genetic; D011153:Population / Q000235:genetics*; D012800:Siberia
chemical_list: D016207:Cytokines; D007073:Immunoglobulin E
keywords: climate and geographic factors; genetic diversity; immune disorders; populations of Northern Eurasia; single nucleotide polymorphisms