title: Ultrasound-Induced Reactive Oxygen Species Mediated Therapy and Imaging Using a Fenton Reaction Activable Polymersome.
abstract: Ultrasound techniques have been extensively employed for diagnostic purposes. Because of its features of low cost, easy access, and noninvasive real-time imaging, toward clinical practice it is highly anticipated to simply use diagnostic ultrasound to concurrently perform imaging and therapy. We report a H2O2-filled polymersome to display echogenic reflectivity and reactive oxygen species-mediated cancer therapy simply triggered by the microultrasound diagnostic system accompanied by MR imaging. Instead of filling common perfluorocarbons, the encapsulation of H2O2 in H2O2/Fe3O4-PLGA polymersome provides O2 as the echogenic source and (•)OH as the therapeutic element. On exposure to ultrasound, the polymersome can be easily disrupted to yield (•)OH through the Fenton reaction by reaction of H2O2 and Fe3O4. We showed that malignant tumors can be completely removed in a nonthermal process.
authors.affiliation: Department of Chemistry and Advanced Optoelectronic Technology Center, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Wei-Peng
authors.initials: WP
authors.lastname: Li
authors.affiliation: Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital , Kaohsiung 833, Taiwan.
authors.forename: Chia-Hao
authors.initials: CH
authors.lastname: Su
authors.affiliation: Department of Chemistry and Advanced Optoelectronic Technology Center, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Yi-Ching
authors.initials: YC
authors.lastname: Chang
authors.affiliation: Department of Chemistry and Advanced Optoelectronic Technology Center, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Yu-Jiung
authors.initials: YJ
authors.lastname: Lin
authors.affiliation: Department of Chemistry and Advanced Optoelectronic Technology Center, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Chen-Sheng
authors.initials: CS
authors.lastname: Yeh
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D052203:Ferrosoferric Oxide / Q000737:chemistry* / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis / Q000378:metabolism*; D019344:Lactic Acid / Q000737:chemistry* / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental; D011100:Polyglycolic Acid / Q000737:chemistry* / Q000378:metabolism; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D014464:Ultrasonic Therapy / Q000379:methods*
chemical_list: D003287:Contrast Media; D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D006861:Hydrogen Peroxide; D052203:Ferrosoferric Oxide
keywords: hydrogen peroxide; magnetic resonance imaging; polymersome; sonodynamic therapy; ultrasound