title: Preparation, in-vitro and in-vivo characterisation of CoQ10 microparticles: electrospraying-enhanced bioavailability.
abstract: OBJECTIVE
  This study aimed to prepare Coenzyme Q10 (CoQ10) microparticles using electrospraying technology, and evaluate the in-vitro properties and in-vivo oral bioavailability.
  
  
  RESULTS
  Electrospraying was successfully used to prepare CoQ10 to enhance its solubility and dissolution properties. In-vitro evaluation of the electrosprayed microparticles showed bioavailability-enhancing properties such as reduced crystallinity and particle size. The formulation was evaluated using dissolution study and in-vivo oral bioavailability using rat model. The dissolution study revealed enhanced dissolution properties of electrosprayed microparticles compared with physical mixture and raw material. The absorption profiles showed increasing mean plasma levels CoQ10 in the following order: raw material < physical mixture < electrosprayed microparticles.
  
  
  CONCLUSIONS
  Based on the findings in this study, electrospraying is a highly prospective technology to produce functional nano- and micro-structures as delivery vehicles for drugs with poor oral bioavailability due to rate-limiting solubility.
authors.affiliation: School of Pharmaceutical Sciences, UniversitiSains Malaysia, Penang, Malaysia.
authors.forename: Wai Yee
authors.initials: WY
authors.lastname: Fung
authors.affiliation: School of Industrial Technology, Universiti Sains Malaysia, Penang, Malaysia.
authors.forename: Min Tze
authors.initials: MT
authors.lastname: Liong
authors.affiliation: School of Pharmaceutical Sciences, UniversitiSains Malaysia, Penang, Malaysia.
authors.forename: Kah Hay
authors.initials: KH
authors.lastname: Yuen
mesh_terms: D065567:Absorption, Physiological; D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D008297:Male; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D017207:Rats, Sprague-Dawley; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry
chemical_list: D014451:Ubiquinone; C024989:coenzyme Q10
keywords: CoQ10; amorphisation; bioavailability; dissolution; electrospraying; microparticles