title: Anti-inflammatory activity of Kochia scoparia fruit on contact dermatitis in mice.
abstract: The mature fruit of Kochia scoparia (L.) Schrad. is widely administered in China and Korea as a medicinal herb for treatment of skin diseases, diabetes mellitus and rheumatoid arthritis. The present study investigated the effects of methanol extracts of K. scoparia dried fruit (MEKS) on ear swelling, histopathological changes (such as epidermal acanthosis, spongiosis and immune cell infiltration) and cytokine production in 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis mice. Topical application of MEKS inhibited DNFB-induced ear thickness and weight increases, as well as DNFB-induced epidermal acanthosis, spongiosis and immune cell infiltration. In addition, treatment with MEKS significantly decreased the levels of tumor necrosis factor-α, interferon-γ and monocyte chemotactic protein-1 in inflamed tissues. These data indicate that the mature fruit of K. scoparia has the potential to be administered for the treatment of inflammatory skin diseases and that the anti-inflammatory action of K. scoparia is involved in the inhibition of type 1 T helper cell skewing reactions.
authors.affiliation: Department of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan, Gyeongsangnam‑do 626‑870, Republic of Korea.
authors.forename: Suzy
authors.initials: S
authors.lastname: Jo
authors.affiliation: Department of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan, Gyeongsangnam‑do 626‑870, Republic of Korea.
authors.forename: Junghyun
authors.initials: J
authors.lastname: Ryu
authors.affiliation: Department of Oral Pathology, School of Dentistry, Pusan National University, Yangsan, Gyeongsangnam‑do 626‑870, Republic of Korea.
authors.forename: Hye-Yeon
authors.initials: HY
authors.lastname: Han
authors.affiliation: Department of Herbology, College of Korean Medicine, Wonkwang University, Iksan, Jeollabuk‑do 565-806, Republic of Korea.
authors.forename: Geumsan
authors.initials: G
authors.lastname: Lee
authors.affiliation: Department of Oral Pathology, School of Dentistry, Pusan National University, Yangsan, Gyeongsangnam‑do 626‑870, Republic of Korea.
authors.forename: Mi Heon
authors.initials: MH
authors.lastname: Ryu
authors.affiliation: Department of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan, Gyeongsangnam‑do 626‑870, Republic of Korea.
authors.forename: Hyungwoo
authors.initials: H
authors.lastname: Kim
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D027467:Bassia scoparia / Q000737:chemistry*; D001835:Body Weight / Q000187:drug effects; D018932:Chemokine CCL2 / Q000378:metabolism; D003877:Dermatitis, Contact / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D004139:Dinitrofluorobenzene; D004423:Ear / Q000473:pathology; D004817:Epidermis / Q000187:drug effects / Q000473:pathology; D005638:Fruit / Q000737:chemistry*; D007249:Inflammation / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D008297:Male; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; C491768:Ccl2 protein, mouse; D018932:Chemokine CCL2; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma; D004139:Dinitrofluorobenzene