title: Immunoexpression of Glucose Transporters 1 and 3 and Macrophage Colony-Stimulating Factor in Central and Peripheral Giant Cell Lesions of the Jaws.
abstract: OBJECTIVE
  The peripheral giant cell lesion (PGCL) is a reactive process associated with a local irritating factor that shows low recurrence after treatment, especially if the irritating factor is eliminated. In contrast, the central giant cell lesion (CGCL) presents variable clinical behavior ranging from slow and asymptomatic growth without recurrence to rapid, painful, and recurrent growth. The immunoexpression of glucose transporter (GLUT)-1, GLUT-3, and macrophage colony-stimulating factor (M-CSF) was compared in CGCL and PGCL.
  
  
  METHODS
  Twenty nonaggressive CGCLs, 20 aggressive CGCLs, and 20 PGCLs were selected for analysis of the immunoexpression of GLUT-1, GLUT-3, and M-CSF in multinuclear giant cells (MGCs) and mononuclear cells (MCs).
  
  
  RESULTS
  There was a difference in the percentage of immunoreactive cells of GLUT-1 and GLUT-3 in MC components among lesions and in the intensity of GLUT-1 in MCG and MC components, GLUT-3 in MGC components, and M-CSF in MC components.
  
  
  CONCLUSIONS
  These results suggest that GLUT-1, GLUT-3, and M-CSF could play a role in the pathogenesis of the lesions studied. The stronger immunostaining of these proteins in MCs shows that these cells have greater metabolic activity and osteoclastogenesis, especially in aggressive CGCL. The MCs showed a stronger relation than the MGCs to the pathogenesis of the studied lesions.
authors.affiliation: Professor, Universidade Estadual da Paraíba, Araruna, PB, Brazil.
authors.forename: Rodrigo Gadelha
authors.initials: RG
authors.lastname: Vasconcelos
authors.affiliation: Professor, Universidade Federal de Sergipe, Lagarto, SE, Brazil.
authors.forename: Felipe Rodrigues
authors.initials: FR
authors.lastname: de Matos
authors.affiliation: Professor, Universidade Estadual da Paraíba, Araruna, PB, Brazil.
authors.forename: Marcelo Gadelha
authors.initials: MG
authors.lastname: Vasconcelos
authors.affiliation: Dentist, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Anderson Nicolly Fernandes
authors.initials: AN
authors.lastname: da Costa
authors.affiliation: Professor, Postgraduate Program, Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil. Electronic address: lmgqueiroz@hotmail.com.
authors.forename: Lélia Maria Guedes
authors.initials: LM
authors.lastname: Queiroz
mesh_terms: D015726:Giant Cells / Q000378:metabolism; D051272:Glucose Transporter Type 1 / Q000378:metabolism* / Q000502:physiology; D051274:Glucose Transporter Type 3 / Q000378:metabolism* / Q000502:physiology; D006101:Granuloma, Giant Cell / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007571:Jaw Diseases / Q000378:metabolism* / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D016173:Macrophage Colony-Stimulating Factor / Q000378:metabolism* / Q000502:physiology
chemical_list: D051272:Glucose Transporter Type 1; D051274:Glucose Transporter Type 3; D016173:Macrophage Colony-Stimulating Factor