title: Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women.
abstract: BACKGROUND
  Serum uric acid (SUA) and triglyceride (TG) levels are strongly correlated with insulin resistance; however, the association after a walking exercise program in community-dwelling older women has not been investigated.
  
  
  METHODS
  The present study included 100 postmenopausal women (mean ± standard deviation, 68 ± 7 years) from a rural village in Japan. The Nordic walking program of 120 min per week was performed for 12 weeks. Before and after the intervention, SUA, TG, various relevant factors and homeostasis model assessment of insulin resistance (HOMA-IR) were measured.
  
  
  CONCLUSIONS
  Multivariate linear regression analysis showed that baseline TG and γ-glutamyltransferase (GGT) were significantly associated with baseline HOMA-IR. After the 12-week training program, changes in TG, SUA and GGT were significantly associated with changes in HOMA-IR. In addition to their direct associations, we observed a synergistic association between changes in TG and SUA and changes in HOMA-IR. Participants were divided into three groups (tertiles) according to changes in TG and SUA. The tertiles of changes in SUA correlated significantly with changes in HOMA-IR in participants in the tertile with the greatest decrease in TG (r = 0.525, p = 0.001), but not in the other two tertiles of change in TG (r = 0.049, p = 0.699). There was a significant interaction between SUA and TG for changes in HOMA-IR (β = 0.281, p = 0.005). These results suggest that changes in TG and SUA are synergistic factors associated with changes in insulin resistance after a 12-week walking exercise program in community-dwelling older women.
authors.affiliation: a Department of Community Medicine.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kawamoto
authors.affiliation: b Department of Geriatric Medicine , Ehime University Graduate School of Medicine , Ehime , Japan.
authors.forename: Takeaki
authors.initials: T
authors.lastname: Katoh
authors.affiliation: a Department of Community Medicine.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ninomiya
authors.affiliation: a Department of Community Medicine.
authors.forename: Teru
authors.initials: T
authors.lastname: Kumagi
authors.affiliation: a Department of Community Medicine.
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
authors.affiliation: b Department of Geriatric Medicine , Ehime University Graduate School of Medicine , Ehime , Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kohara
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D057187:Independent Living; D007333:Insulin Resistance / Q000502:physiology*; D007564:Japan; D008875:Middle Aged; D012424:Rural Population; D014280:Triglycerides / Q000097:blood*; D014527:Uric Acid / Q000097:blood*; D016138:Walking / Q000502:physiology*
chemical_list: D014280:Triglycerides; D014527:Uric Acid
keywords: Synergism; insulin resistance; serum uric acid; triglycerides; walking exercise