title: Long and short range order structural analysis of In-situ formed biphasic calcium phosphates.
abstract: BACKGROUND
  Biphasic calcium phosphates (BCP) have attracted considerable attention as a bone graft substitute. In this study, BCP were prepared by aqueous co-precipitation and calcination method. The crystal phases of in-situ formed BCP consisting of hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) were controlled by the degree of calcium deficiency of precursors. The long and short range order structures of biphasic mixtures was investigated using Rietveld refinement technique and high resolution Raman spectroscopy. The refined structural parameters of in-situ formed BCP confirmed that all the investigated structures have crystallized in the corresponding hexagonal (space group P63/m) and rhombohedral (space group R3c) structures.
  
  
  RESULTS
  The crystal phases, Ca/P molar ratio, and lattice parameters of in-situ formed BCP consisting of HAp and β-TCP were controlled by the degree of calcium deficiency of calcium phosphate precursors. The significant short range order structural change of BCP was determined by Raman analysis.
  
  
  CONCLUSIONS
  The long and short range order structural changes of in-situ formed BCP might be due to the coexistence of β-TCP and HAp crystal phases.
authors.affiliation: School of Materials Science and Engineering, Pusan National University, Busan, 609-735 Republic of Korea.
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
authors.affiliation: School of Nano and Advanced Materials, Gyeongsang National University, Jinju, Gyeongnam 660-701 Republic of Korea.
authors.forename: Kyu-Hong
authors.initials: KH
authors.lastname: Hwang
authors.affiliation: Korea Institute of Industrial Technology, Busan, 618-230 Republic of Korea.
authors.forename: Ju Dong
authors.initials: JD
authors.lastname: Lee
authors.affiliation: School of Materials Science and Engineering, Pusan National University, Busan, 609-735 Republic of Korea.
authors.forename: Hong-Chae
authors.initials: HC
authors.lastname: Park
authors.affiliation: School of Materials Science and Engineering, Pusan National University, Busan, 609-735 Republic of Korea.
authors.forename: Seog-Young
authors.initials: SY
authors.lastname: Yoon
keywords: Biphasic calcium phosphate; Raman spectroscopy; Rietveld refinement