title: Impact of the polymorphism in vitamin D receptor gene BsmI and the risk of systemic lupus erythematosus: an updated meta-analysis.
abstract: The etiology of system lupus erythematosus (SLE) still remains unclear, and vitamin D is associated with immune response. Although a few studies are conducted to investigate the association between polymorphism in vitamin D receptor (VDR) genes and SLE risk, their results are conflicting. Following the guideline of PRISMA, we conducted a systematic search and meta-analysis of the BsmI polymorphism rs1544410 and the risk of SLE. The pooled odds ratios (OR) and its 95 % confidential interval (CI) were calculated by using Stata Version 10 with dominant and recessive model and allele analyses. Nine studies were included in our meta-analysis with a total of 1247 SLE cases and 1687 controls. No significant association was found in both models in the overall population. Only Bb + BB genotypes showed a significantly elevated SLE risk in Asian subgroup with an OR of 3.26 (95 % CI = 1.30-8.17) while no significance was observed in Caucasian population. Notably, B allele significantly increased the SLE risk among Asian population with an OR of 2.29 (95 % CI = 1.14-4.61). No positive findings were reported in Caucasian population and in the overall analysis. In Asian population, Bb + BB genotype and B allele can significantly increase the SLE risk.
authors.affiliation: Rheumatism Department, The Second Clinical Medical College, Fujian Medical University, Quanzhou, Fujian, 362000, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Hu
authors.affiliation: Rheumatism Department, The Second Clinical Medical College, Fujian Medical University, Quanzhou, Fujian, 362000, China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Niu
authors.affiliation: Department of Infectious Disease Control, Xiamen Center for Disease Control and Prevention, Xiamen, Fujian, 361021, China.|School of Public Health, Fujian Medical University, Fuzhou, Fujian, 350004, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Rheumatism Department, The Second Clinical Medical College, Fujian Medical University, Quanzhou, Fujian, 362000, China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Chen
authors.affiliation: Rheumatism Department, The Second Clinical Medical College, Fujian Medical University, Quanzhou, Fujian, 362000, China. linling_qzf2@163.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Lin
mesh_terms: D000483:Alleles; D044466:Asian People; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011786:Quality Control; D018167:Receptors, Calcitriol / Q000235:genetics*; D012044:Regression Analysis; D012307:Risk Factors; D044465:White People
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human; C053864:endodeoxyribonuclease BsmI; D015252:Deoxyribonucleases, Type II Site-Specific
keywords: Meta-analysis; Polymorphism; System lupus erythematosus; Vitamin D receptor