title: Preparation and characterization of electrospun in-situ cross-linked gelatin-graphite oxide nanofibers.
abstract: Electrospun gelatin(Gel) nanofibers scaffold has such defects as poor mechanical property and quick degradation due to high solubility. In this study, the in situ cross-linked electrospinning technique was used for the production of gelatin nanofibers. Deionized water was chosen as the spinning solvent and graphite oxide (GO) was chosen as the enhancer. The morphological structure, porosity, thermal property, moisture absorption, and moisture retention performance, hydrolysis resistance, mechanical property, and biocompatibility of the produced nanofibers were investigated. Compared with in situ cross-linked gelatin nanofibers scaffold, in situ cross-linked Gel-GO nanofibers scaffold has the following features: (1) the hydrophilicity, moisture absorption, and moisture retention performance slightly reduce, while the hydrolysis resistance is improved; (2) the breaking strength, breaking elongation, and Young's modulus are significantly improved; (3) the porosity slightly reduces while the biocompatibility considerably increases. The in situ cross-linked Gel-GO nanofibers scaffold is likely to be applied in such fields as drug delivery and scaffold for skin tissue engineering.
authors.affiliation: a Chemical Engineering and Biotechnology , College of Chemistry, Donghua University , Shanghai , P.R. China.|b College of Materials and Textile Engineering , Jiaxing University , Zhejiang Province , P.R. China.
authors.forename: Jianchao
authors.initials: J
authors.lastname: Zhan
authors.affiliation: c Faculty of Engineering and Industrial Sciences , Swinburne University of Technology , Hawthorn , Australia.
authors.forename: Yosry
authors.initials: Y
authors.lastname: Morsi
authors.affiliation: d Department of Chemistry , College of Science, King Saud University , Riyadh , Kingdom of Saudi Arabia.|e Faculty of Science, Department of Chemistry , Tanta University , Tanta , Egypt.
authors.forename: Hany
authors.initials: H
authors.lastname: Ei-Hamshary
authors.affiliation: d Department of Chemistry , College of Science, King Saud University , Riyadh , Kingdom of Saudi Arabia.
authors.forename: Salem S
authors.initials: SS
authors.lastname: Al-Deyab
authors.affiliation: a Chemical Engineering and Biotechnology , College of Chemistry, Donghua University , Shanghai , P.R. China.
authors.forename: Xiumei
authors.initials: X
authors.lastname: Mo
mesh_terms: D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004560:Electricity; D005780:Gelatin / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006868:Hydrolysis; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D055595:Mechanical Phenomena; D051379:Mice; D057139:Nanofibers / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D016062:Porosity; D012867:Skin / Q000166:cytology; D012997:Solvents / Q000737:chemistry; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D010087:Oxides; D012997:Solvents; D006108:Graphite; D005780:Gelatin
keywords: Gelatin; electrospinning; graphite oxide; nanofibers; scaffold