title: Rapid predictors for the occurrence of reduced left ventricular ejection fraction between LAD and non-LAD related ST-elevation myocardial infarction.
abstract: BACKGROUND
  Reduced left ventricular ejection fraction (LVEF) after acute myocardial infarction (AMI), which implies the occurrence of cardiac dysfunction, impacts cardiac prognosis, even after primary percutaneous coronary intervention (PCI). This study was designed to clarify the difference of clinical and angiographic predictors for reduced LVEF in ST-elevation myocardial infarction (STEMI) patients with left anterior descending artery (LAD) or non-LAD vessel as culprit artery.
  
  
  METHODS
  This was a retrospective study to review a total of 553 patients of STEMI underwent primary PCI in our hospital. All patients underwent echocardiography. Univariate analysis, multivariate analysis and classification and regression tree (CART) were performed between LAD related AMI and non-LAD related STEMI. The primary outcome was the occurrence of reduced LVEF 4-6 days after PCI.
  
  
  RESULTS
  In this study, culprit arteries of STEMI were 315 in LAD system (6 in left main artery, 309 in LAD) and 238 in non-LAD system (63 in left circumflex and 175 in right coronary artery). Compared with non-LAD group, post-MI LVEF was significantly reduced in LAD related STEMI group (52.4 ± 9.3% vs. 57.1 ± 7.8%, P < 0.01). Multivariate analysis indicated that elder (>65 years), time to hospital and proximal occlusion were associated with reduced LVEF (<55%) in LAD related STEMI patients. However, in non-LAD patients, time to hospital, multivessel stenosis and post-PCI blood pressure predicted the occurrence of reduced LVEF. Furthermore, CART analysis also obtained similar findings.
  
  
  CONCLUSIONS
  Patients with LAD or non-LAD related STEMI could suffer reduced LVEF, while the clinical and angiographic predictors for the occurrence were different.
authors.affiliation: Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, PR China.
authors.forename: Zhang-Wei
authors.initials: ZW
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, PR China.
authors.forename: Zi-Qing
authors.initials: ZQ
authors.lastname: Yu
authors.affiliation: Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, PR China.
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Yang
authors.affiliation: Department of Endocrinology Medicine, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
authors.forename: Ying-Hua
authors.initials: YH
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, PR China. Qian.juying@zs-hospital.sh.cn.
authors.forename: Ju-Ying
authors.initials: JY
authors.lastname: Qian
authors.affiliation: Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, PR China.
authors.forename: Xian-Hong
authors.initials: XH
authors.lastname: Shu
authors.affiliation: Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, PR China. Ge.junbo@hotmail.com.
authors.forename: Jun-Bo
authors.initials: JB
authors.lastname: Ge
mesh_terms: D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D017023:Coronary Angiography; D054059:Coronary Occlusion / Q000150:complications*; D023921:Coronary Stenosis / Q000150:complications*; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000150:complications* / Q000601:surgery; D062645:Percutaneous Coronary Intervention / Q000706:statistics & numerical data*; D011379:Prognosis; D012044:Regression Analysis; D012189:Retrospective Studies; D013318:Stroke Volume; D061665:Time-to-Treatment / Q000706:statistics & numerical data*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology*