title: [Noninvasive Estimation of Liver Fibrosis and Hepatocellular Carcinoma Development Using WFA(+)-M2BP in Chronic Hepatitis C Patients].
abstract: Wisteria floribunda agglutinin (WFA) -positive human Mac-2-binding protein (WFA(+)-M2BP) is a new glycol marker related to liver fibrosis. The aim of the present study was to evaluate WFA(+)-M2BP as a predictor of liver fibrosis and hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C. A total of 115 patients with chronic hepatitis C who underwent liver biopsy were included, and the diagnostic accuracy of WFA(+)-M2BP for liver fibrosis was evaluated. A case-control study was conducted including 14 patients with chronic hepatitis C who developed HCC and 52 controls to estimate the utility of WFA(+)-M2BP as a predictor of HCC development. WFA(+)-M2BP increased stepwisely with the progression of liver fibrosis (p < 0.001). The cumulative incidence of HCC development was significantly higher in patients with WFA(+)-M2BP ≥ 4.2 (p < 0.001) or in those with time-course changes in WFA(+)-M2BP (ΔWFA(+)-M2BP/year) =0.3(p=0.03). Multivariate analyses demonstrated that WFA(+)-M2BP ≥ 4.2 [hazard ratio (HR): 4.1, p = 0.04], AWFA'-M2BP/year ≥ 0.3 (HR: 5.5, p=0.008), and AFP ≥ 10 ng/mL (HR: 4.7, p = 0.03) were independent predictive factors of HCC development. Based on these data, we developed a simple scoring system to predict HCC development using these three factors. Using these scores, patients were classified into four groups; the cumulative incidence of HCC development significantly increased with increasing scores (p < 0.001). WFA(+)-M2BP measurements were useful as a predictor of liver fibrosis and HCC development. Furthermore, real-time monitoring of WFA(+)-M2BP may be a novel predictor of HCC development.
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Tamaki
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kurosaki
authors.forename: Namiki
authors.initials: N
authors.lastname: Izumi
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis*; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000209:etiology; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications / Q000473:pathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology; D008113:Liver Neoplasms / Q000209:etiology; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis*; D008875:Middle Aged; D037121:Plant Lectins / Q000032:analysis*; D034781:Receptors, N-Acetylglucosamine / Q000032:analysis*
chemical_list: D000951:Antigens, Neoplasm; D008562:Membrane Glycoproteins; D037121:Plant Lectins; D034781:Receptors, N-Acetylglucosamine; C114782:TAA90K protein, human; C040129:wisteria lectin