title: Nuclear Image-Guided Approaches for Cardiac Resynchronization Therapy (CRT).
abstract: Cardiac resynchronization therapy (CRT) is a standard treatment for patients with heart failure. However, 30-40 % of the patients having CRT do not respond to CRT with improved clinical symptom and cardiac functions. It is important for CRT response that left ventricular (LV) lead is placed away from scar and at or near the site of the latest mechanical activation. Nuclear image-guided approaches for CRT have shown significant clinical value to assess LV myocardial viability and mechanical dyssynchrony, recommend the optimal LV lead position, and navigate the LV lead to the target coronary venous site. All these techniques, once validated and implemented, should impact the current clinical practice.
authors.affiliation: School of Computing, University of Southern Mississippi, 730 East Beach Blvd, Long Beach, MS, 39560, USA. weihua.zhou@usm.edu.
authors.forename: Weihua
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd NE, Atlanta, GA, USA. ernest.garcia@emory.edu.
authors.forename: Ernest V
authors.initials: EV
authors.lastname: Garcia
mesh_terms: D058406:Cardiac Resynchronization Therapy / Q000379:methods* / Q000401:mortality; D058409:Cardiac Resynchronization Therapy Devices; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D025321:Surgery, Computer-Assisted; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional; D016277:Ventricular Function, Left
keywords: Cardiac resynchronization therapy (CRT); Heart failure (HF); Left ventricle (LV); Mechanical dyssynchrony