title: Single injection of clenbuterol into newly hatched chicks decreases abdominal fat pad weight in growing broiler chickens.
abstract: The aim of the current study was to examine the effects of clenbuterol injection into newly hatched chicks on both the abdominal fat pad tissue weight and the skeletal muscle weight during subsequent growth. Twenty-seven 1-day-old chicks were divided into two groups, receiving either a single intraperitoneal (i.p.) injection of clenbuterol (0.1 mg/kg body weight) or phosphate-buffered saline (PBS). Body weight gain, feed intake and feed conversion ratio were not affected by clenbuterol injection during the 5-week experimental period, while the abdominal fat pad tissue weight of the clenbuterol-injected chicks was lower than that of the control chicks at 5 weeks post-injection. Plasma non-esterified fatty acid concentrations were significantly increased in the clenbuterol-injected chicks, while plasma triacylglycerol concentrations did not differ. Additionally, the enzymatic activity of fatty acid synthase was lower in the liver of the clenbuterol-injected chicks. Conversely, the skeletal muscle weights were not affected by clenbuterol injection. These results suggest that a single clenbuterol injection into 1-day-old chicks decreases the abdominal fat pad tissue weight, but may not affect skeletal muscle weights during growth. © 2015 Japanese Society of Animal Science.
authors.affiliation: Department of Biochemical Science and Technology, Kagoshima University, Kagoshima, Japan. ijiri@chem.agri.kagoshima-u.ac.jp.
authors.forename: Daichi
authors.initials: D
authors.lastname: Ijiri
authors.affiliation: Department of Biochemical Science and Technology, Kagoshima University, Kagoshima, Japan.
authors.forename: Kanae
authors.initials: K
authors.lastname: Ishitani
authors.affiliation: Department of Biochemical Science and Technology, Kagoshima University, Kagoshima, Japan.|Animal Production Research Institute, Sakha Station, Kafr El-Sheikh, Egypt.
authors.forename: Mahmoud Mohamed Hamza
authors.initials: MM
authors.lastname: El-Deep
authors.affiliation: Department of Biochemical Science and Technology, Kagoshima University, Kagoshima, Japan.
authors.forename: Mana
authors.initials: M
authors.lastname: Kawaguchi
authors.affiliation: Department of Biochemical Science and Technology, Kagoshima University, Kagoshima, Japan.
authors.forename: Saki
authors.initials: S
authors.lastname: Shimamoto
authors.affiliation: Department of Biochemical Science and Technology, Kagoshima University, Kagoshima, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Ishimaru
authors.affiliation: Department of Biochemical Science and Technology, Kagoshima University, Kagoshima, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ohtsuka
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism*; D000818:Animals; D002645:Chickens / Q000254:growth & development* / Q000378:metabolism*; D002976:Clenbuterol / Q000008:administration & dosage* / Q000494:pharmacology*; D064429:Fatty Acid Synthases / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007274:Injections, Intraperitoneal; D008099:Liver / Q000201:enzymology; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects
chemical_list: D005230:Fatty Acids, Nonesterified; D064429:Fatty Acid Synthases; D002976:Clenbuterol
keywords: adipose tissue; beta-2 agonist; chicken; clenbuterol; skeletal muscle