title: A meta-analysis of xeroderma pigmentosum gene D Ls751Gln polymorphism and susceptibility to hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is one of most common malignant tumors worldwide, but with unclear mechanisms. Xeroderma pigmentosum gene D (XPD) is one important DNA damage repair gene and can be involved in protein mutation. Currently little has been known about XPD polymorphism and HCC susceptibility in Chinese people. This study used a meta-analysis approach to comprehensively investigate the correlation between XPD polymorphism and HCC susceptibility in Chinese population, based on previously published literatures. A computer retrieval system was used to collect all case-control studies about XPD Lys751Gln polymorphism and HCC susceptibility. Data in literatures were extracted for meta-analysis. After the primary screening, four independent studies, which were published in 3 English articles and one Chinese article, were recruited in this study. There were 1,717 samples included in all studies. Using Gln/Gln + Lys/Gln, Lys/Lys + Lys/Gln and Lys allels as the reference, HCC disease alleles including Lys/Lys, Gln/Gln and Gln had OR values (95% CI, I(2)) of 1.007 (0.657~4.672, 91%), 3.516 (0.220~20.661, 48%) and 3.225 (0.278~12.326, 84%), respectively. The polymorphism of XPD751 loci is closely correlated with primary HCC. Lys751Gln polymorphism of XPD gene can be used as one susceptibility factor for HCC.
authors.affiliation: Department of Infectious Diseases, Xi'an Jiaotong University School of Medicine, General Hospital of Ningxia Medical University Yinchuan 750004, Ningxia, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University School of Medicine Xi'an 710061, Shanxi, China.
authors.forename: Yingren
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Infectious Diseases, Infectious Disease Department of General Hospital of Ningxia Medical University Yinchuan 750004, Ningxia, China.
authors.forename: Aiyun
authors.initials: A
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, Infectious Disease Department of General Hospital of Ningxia Medical University Yinchuan 750004, Ningxia, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Infectious Diseases, Infectious Disease Department of General Hospital of Ningxia Medical University Yinchuan 750004, Ningxia, China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Infectious Diseases, Infectious Disease Department of General Hospital of Ningxia Medical University Yinchuan 750004, Ningxia, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human
keywords: Lys715Gln; Xeroderma pigmentosum gene D; gene polymorphism; hepatocellular carcinoma; meta-analysis