title: Genetic predisposition resulting in sinusoidal obstruction syndrome in a patient with resected sigmoid cancer on adjuvant oxaliplatin.
abstract: A Chinese man who had undergone a curative high anterior resection for sigmoid cancer was administrated XELOX (capecitabine and oxaliplatin) as postoperative adjuvant chemotherapy. He subsequently developed sinusoidal obstruction syndrome (SOS) that resolved on discontinuation of XELOX treatment. Genetic evaluation determined that he had the GSTT1-null and GSTM1-null genotype, known to be an independent risk factor for developing oxaliplatin-induced SOS.
authors.affiliation: Department of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
authors.forename: Si Xuan
authors.initials: SX
authors.lastname: Koo
authors.affiliation: National Cancer Centre Singapore, Singapore, Singapore.
authors.forename: Sock Hoai
authors.initials: SH
authors.lastname: Chan
authors.affiliation: National Cancer Centre Singapore, Singapore, Singapore.
authors.forename: Joanne
authors.identifier: http://orcid.org/0000-0003-1558-3627
authors.initials: J
authors.lastname: Ngeow
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D000069287:Capecitabine; D017024:Chemotherapy, Adjuvant; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced* / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D010071:Oxaloacetates; D012811:Sigmoid Neoplasms / Q000150:complications* / Q000601:surgery
chemical_list: D000069287:Capecitabine; D003841:Deoxycytidine; D005472:Fluorouracil; D005982:Glutathione Transferase; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D010071:Oxaloacetates; C413545:glutathione S-transferase T1