title: The Imaging Modulography Technique Revisited for High-Definition Intravascular Ultrasound: Theoretical Framework.
abstract: Mechanical characterization of atherosclerotic lesions remains an essential step for the detection of vulnerable plaques (VPs). Recently, an intravascular ultrasound (IVUS) elasticity reconstruction method (iMOD) has been tested in vivo by our group. The major limitation of iMOD is the need to estimate the strain field in the entire VP despite attenuated depth penetration signals when using high-definition (HD) IVUS systems. Therefore, an extended iMOD approach (E-iMOD) was designed and applied to coronary lesions of patients imaged in vivo with IVUS. The E-iMOD method (i) quantified necrotic core areas with a mean absolute relative error of 3.5 ± 3.5% and (ii) identified Young's moduli of the necrotic cores and fibrous regions with mean values of 5.7 ± 0.8 kPa and 794.5 ± 22.0 kPa instead of 5 kPa and 800 kPa, respectively. This study demonstrates the potential of the improved HD-IVUS modulography technique E-iMOD to characterize coronary VPs.
authors.affiliation: Laboratory TIMC-IMAG/DyCTiM, UJF, CNRS UMR 5525, Grenoble, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Tacheau
authors.affiliation: Laboratory LMGC, CNRS UMR 5508, University of Montpellier II, Montpellier, France.
authors.forename: Simon
authors.initials: S
authors.lastname: Le Floc'h
authors.affiliation: Department of Hemodynamics and Interventional Cardiology, Hospices Civils de Lyon and Claude Bernard University Lyon, INSERM Unit 886, Lyon, France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Finet
authors.affiliation: Department of Electrical and Computer Engineering, University of Rochester, Rochester, New York, USA.
authors.forename: Marvin M
authors.initials: MM
authors.lastname: Doyley
authors.affiliation: Laboratory of Integrative Cardiovascular Imaging Science, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Roderic I
authors.initials: RI
authors.lastname: Pettigrew
authors.affiliation: Laboratory of Biorheology and Medical Ultrasonics, University of Montreal Hospital Research Center (CRCHUM), Montréal, Québec, Canada.
authors.forename: Guy
authors.initials: G
authors.lastname: Cloutier
authors.affiliation: Laboratory TIMC-IMAG/DyCTiM, UJF, CNRS UMR 5525, Grenoble, France; University Grenoble-Alpes, Polytech Annecy-Chambéry, Le Bourget du Lac, France. Electronic address: jacques.ohayon@imag.fr.
authors.forename: Jacques
authors.initials: J
authors.lastname: Ohayon
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D018084:Ultrasonography, Interventional / Q000379:methods*
keywords: Coronary disease; Elastography; Inverse problem; Linear elasticity; Modulography; Vulnerable plaques