title: Efficacy of Tranexamic Acid on Myomectomy-Associated Blood Loss in Patients With Multiple Myomas: A Randomized Controlled Clinical Trial.
abstract: To evaluate the efficacy of tranexamic acid (TA) in decreasing blood loss during and after open myomectomy for patients with 3 or more uterine fibroids.
  
  
  
  This prospective randomized trial was conducted among 132 women subjected to abdominal myomectomy. Patients were equally divided into 2 groups by simple randomization. The study group received perioperative intravenous TA while the control group did not. Intraoperative blood loss was calculated by measuring the volume in the suction apparatus and weighing the surgical swabs in addition to postoperative blood loss collected via a suction drain. Hemoglobin and hematocrit values were determined preoperatively and on the third postoperative day for all cases. Any adverse effects were recorded in both groups.
  
  
  
  No significant difference was found between the two groups regarding age, body mass index, number, and size of myomas removed. The TA group showed lower amount of blood loss (407 mL) when compared to control group (677 mL; P < .01). Risk estimation has revealed that treatment with TA resulted in decrease in risk of perioperative blood loss by 40%. In the study group, 13 (19.7%) patients required blood transfusion in contrast to 23 (34.8%) patients in the control group (P < .01). Hemoglobin and hematocrit levels were significantly lower in the control group on the third postoperative day (P value = .001) .
  
  
  
  The TA reduces blood loss during and after myomectomy for patients with multiple uterine fibroids.
authors.affiliation: Obstetrics and Gynecology Department, Suez Canal University, Ismaili, Egypt.
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Shaaban
authors.affiliation: Obstetrics and Gynecology Department, Suez Canal University, Ismaili, Egypt dr_magdygyn@yahoo.com.
authors.forename: Magdy R
authors.initials: MR
authors.lastname: Ahmed
authors.affiliation: Obstetrics and Gynecology Department, Suez Canal University, Ismaili, Egypt.
authors.forename: Rasha E
authors.initials: RE
authors.lastname: Farhan
authors.affiliation: Obstetrics and Gynecology Department, Suez Canal University, Ismaili, Egypt.
authors.forename: Hanaa H
authors.initials: HH
authors.lastname: Dardeer
mesh_terms: D000328:Adult; D000933:Antifibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000601:surgery; D011446:Prospective Studies; D014148:Tranexamic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D063186:Uterine Myomectomy / Q000009:adverse effects*; D014594:Uterine Neoplasms / Q000601:surgery
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid
keywords: blood loss; open myomectomy; tranexamic acid