title: Advanced image processing for optical coherence tomographic angiography of macular diseases.
abstract: This article provides an overview of advanced image processing for three dimensional (3D) optical coherence tomographic (OCT) angiography of macular diseases, including age-related macular degeneration (AMD) and diabetic retinopathy (DR). A fast automated retinal layers segmentation algorithm using directional graph search was introduced to separates 3D flow data into different layers in the presence of pathologies. Intelligent manual correction methods are also systematically addressed which can be done rapidly on a single frame and then automatically propagated to full 3D volume with accuracy better than 1 pixel. Methods to visualize and analyze the abnormalities including retinal and choroidal neovascularization, retinal ischemia, and macular edema were presented to facilitate the clinical use of OCT angiography.
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Alex D
authors.initials: AD
authors.lastname: Pechauer
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Hwang
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Simon S
authors.initials: SS
authors.lastname: Gao
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Steven T
authors.initials: ST
authors.lastname: Bailey
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Wilson
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: David
authors.initials: D
authors.lastname: Huang
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Yali
authors.initials: Y
authors.lastname: Jia
keywords: (100.0100) Image processing; (100.2960) Image analysis; (110.4500) Optical coherence tomography; (170.4470) Ophthalmology