title: How to Create an Embryo Penetration Route.
abstract: Numerous past investigations into human implantation have tended to pay attention to the mechanism of embryo adhesion to endometrial cells or embryo invasion into endometrial stromal tissue. For successful pregnancy, however, embryo penetration through the endometrial epithelial cell (EEC) sheet is also absolutely required. To improve the performance of assisted reproductive technology, implantation studies should also focus on EEC dynamics, in particular, the action of EECs during embryo penetration. Although only EEC apoptosis has been proposed as a mechanism for the formation of the embryo penetration route, we have also recently reported that characteristic EEC collective motion, regulated by the epithelial to mesenchymal transition, also plays a key role in permitting embryo penetration. We review here how EECs form embryo penetration routes in light of our findings.
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Hiroshi
authors.identifier: http://orcid.org/0000-0001-6148-7658
authors.initials: H
authors.lastname: Uchida
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Maruyama
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Masuda
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Uchida
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Fumie
authors.initials: F
authors.lastname: Miki
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Hanako
authors.initials: H
authors.lastname: Hihara
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Satomi
authors.initials: S
authors.lastname: Katakura
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Yoshimasa
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology; D010064:Embryo Implantation / Q000276:immunology*; D004622:Embryo, Mammalian / Q000276:immunology*; D004717:Endometrium / Q000166:cytology / Q000276:immunology*; D004847:Epithelial Cells / Q000166:cytology / Q000276:immunology*; D058750:Epithelial-Mesenchymal Transition / Q000276:immunology*; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000276:immunology*
keywords: Apoptosis; endometrial epithelial cell; epithelial to mesenchymal transition; motility; steroid hormone