title: Precision Medicine: Clarity for the Complexity of Dementia.
abstract: Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades in the management of some rare diseases and now gaining broad currency in cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and dementia. This review focuses on the application of precision medicine to address the clinical and biological complexity of two common neurodegenerative causes of dementia: Alzheimer disease and Parkinson disease.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.
authors.forename: Brenna
authors.initials: B
authors.lastname: Cholerton
authors.affiliation: Group Health Research Institute, Seattle, Washington.
authors.forename: Eric B
authors.initials: EB
authors.lastname: Larson
authors.affiliation: Department of Neurology, Oregon Health and Science University, Portland, Oregon; Portland Veterans Affairs Medical Center, Portland, Oregon.
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Quinn
authors.affiliation: Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington; Parkinson's Disease Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington; Department of Neurology, University of Washington, Seattle, Washington.
authors.forename: Cyrus P
authors.initials: CP
authors.lastname: Zabetian
authors.affiliation: Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington; Department of Neurology, University of Washington, Seattle, Washington.
authors.forename: Ignacio F
authors.initials: IF
authors.lastname: Mata
authors.affiliation: Department of Pathology, University of Washington, Seattle, Washington.
authors.forename: C Dirk
authors.initials: CD
authors.lastname: Keene
authors.affiliation: Department of Pathology, University of Washington, Seattle, Washington.
authors.forename: Margaret
authors.initials: M
authors.lastname: Flanagan
authors.affiliation: Department of Medicine, University of Washington, Seattle, Washington.
authors.forename: Paul K
authors.initials: PK
authors.lastname: Crane
authors.affiliation: Department of Neurology, University of Washington, Seattle, Washington; Department of Radiology, University of Washington, Seattle, Washington.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Grabowski
authors.affiliation: Department of Pathology, University of Washington, Seattle, Washington.
authors.forename: Kathleen S
authors.initials: KS
authors.lastname: Montine
authors.affiliation: Department of Pathology, University of Washington, Seattle, Washington. Electronic address: tmontine@uw.edu.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Montine
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D003072:Cognition Disorders / Q000235:genetics / Q000503:physiopathology; D003704:Dementia / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D009154:Mutation; D010300:Parkinson Disease / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy; D057285:Precision Medicine