title: Targeted Radionuclide Therapy of Human Tumors.
abstract: Targeted radionuclide therapy is one of the most intensively developing directions of nuclear medicine. Unlike conventional external beam therapy, the targeted radionuclide therapy causes less collateral damage to normal tissues and allows targeted drug delivery to a clinically diagnosed neoplastic malformations, as well as metastasized cells and cellular clusters, thus providing systemic therapy of cancer. The methods of targeted radionuclide therapy are based on the use of molecular carriers of radionuclides with high affinity to antigens on the surface of tumor cells. The potential of targeted radionuclide therapy has markedly grown nowadays due to the expanded knowledge base in cancer biology, bioengineering, and radiochemistry. In this review, progress in the radionuclide therapy of hematological malignancies and approaches for treatment of solid tumors is addressed.
authors.affiliation: Laboratory of Optical Theranostics, Lobachevsky Nizhny Novgorod State University, Gagarin Ave. 23, Nizhny Novgorod 603950, Russia. S_makariy@rambler.ru.|Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya St, 3, Pushchino, Moscow 142290, Russia. S_makariy@rambler.ru.|Prokhorov Institute of General Physics, Russian Academy of Sciences, Vavilova St, 38, Moscow 119991, Russia. S_makariy@rambler.ru.
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Gudkov
authors.affiliation: Laboratory of Optical Theranostics, Lobachevsky Nizhny Novgorod State University, Gagarin Ave. 23, Nizhny Novgorod 603950, Russia. nat-lekanova@yandex.ru.
authors.forename: Natalya Yu
authors.initials: NY
authors.lastname: Shilyagina
authors.affiliation: Laboratory of Optical Theranostics, Lobachevsky Nizhny Novgorod State University, Gagarin Ave. 23, Nizhny Novgorod 603950, Russia. v.vodeneev@mail.ru.
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Vodeneev
authors.affiliation: Laboratory of Optical Theranostics, Lobachevsky Nizhny Novgorod State University, Gagarin Ave. 23, Nizhny Novgorod 603950, Russia. andrei.zvyagin@mq.edu.au.|ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), Macquarie University, Sydney 2109, Australia. andrei.zvyagin@mq.edu.au.
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Zvyagin
mesh_terms: D016503:Drug Delivery Systems; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D016499:Radioimmunotherapy
keywords: Auger electron; antibody; peptide; radio-immunotherapy; radionuclide; targeted therapy; α-emitter; β-emitter