title: Multivariate pattern analysis of obsessive-compulsive disorder using structural neuroanatomy.
abstract: Magnetic resonance imaging (MRI) studies have revealed brain structural abnormalities in obsessive-compulsive disorder (OCD) patients, involving both gray matter (GM) and white matter (WM). However, the results of previous publications were based on average differences between groups, which limited their usages in clinical practice. Therefore, the aim of this study was to examine whether the application of multivariate pattern analysis (MVPA) to high-dimensional structural images would allow accurate discrimination between OCD patients and healthy control subjects (HCS). High-resolution T1-weighted images were acquired from 33 OCD patients and 33 demographically matched HCS in a 3.0 T scanner. Differences in GM and WM volume between OCD and HCS were examined using two types of well-established MVPA techniques: support vector machine (SVM) and Gaussian process classifier (GPC). We also drew a receiver operating characteristic (ROC) curve to evaluate the performance of each classifier. The classification accuracies for both classifiers using GM and WM anatomy were all above 75%. The highest classification accuracy (81.82%, P<0.001) was achieved with the SVM classifier using WM information. Regional brain anomalies with high discriminative power were based on three distributed networks including the fronto-striatal circuit, the temporo-parieto-occipital junction and the cerebellum. Our study illustrated that both GM and WM anatomical features may be useful in differentiating OCD patients from HCS. WM volume using the SVM approach showed the highest accuracy in our population for revealing group differences, which suggested its potential diagnostic role in detecting highly enriched OCD patients at the level of the individual.
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Hu
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Mental Health Center, Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: Mental Health Center, Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Wanjie
authors.initials: W
authors.lastname: Tang
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Huaiqiang
authors.initials: H
authors.lastname: Sun
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.affiliation: Mental Health Center, Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China. Electronic address: qiyonggong@hmrrc.org.cn.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China. Electronic address: julianahuang@163.com.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D015999:Multivariate Analysis; D009445:Neuroanatomy; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging / Q000473:pathology*; D011569:Psychiatric Status Rating Scales; D060388:Support Vector Machine; D055815:Young Adult
keywords: Gaussian process classifier; Multivariate pattern analysis; Obsessive–compulsive disorder; Structural magnetic resonance imaging; Support vector machine