title: Ultrasound-guided fine-needle aspiration cytology as a diagnostic tool in comparison to ultrasound and MRI for staging in oral- and oropharyngeal squamous cell tumors.
abstract: The aim of this retrospective study was to test the diagnostic performance of ultrasound guided fine-needle aspiration cytology (USFNAC) in comparison to ultrasound (US) and magnetic resonance imaging (MRI) for detecting lymph node metastases in patients with squamous cell carcinoma of the oral and oropharyngeal region. 143 patients with oral cavity and oropharyngeal squamous cell carcinoma were included in the study. US, USFNAC and MRI were routinely performed prior to neck dissection. The results of the imaging studies were compared to histopathology. The sensitivity of MRI was highest at 83%, followed by USFNAC and US at 81% and 73%, respectively. The specificity was highest for FNAC at 100%, followed by MRI and US at 76% and 45%, respectively. Positive predictive value was highest for USFNAC 100%, US 57%, MRI 75% and negative predictive value was 77%, 69% and 84%, respectively. In our patient group with oral and oropharyngeal carcinoma, MRI had a higher sensitivity than USFNAC and US alone. USFNAC provided additional staging information. Especially in an uncertain lymph node situation it can facilitate and optimize preoperative planning with a specificity of 100% regarding tissue entity of cervical lymph nodes.
authors.affiliation: Department of Cranio-Maxillofacial Surgery, Maastricht University Medical Center, P. Debeyelaan 25, AZ 6202 Maastricht, The Netherlands.
authors.forename: Cyriel
authors.initials: C
authors.lastname: Souren
authors.affiliation: Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University Innsbruck, Schöpfstraße 41, 6020 Innsbruck, Austria.
authors.forename: Anita
authors.initials: A
authors.lastname: Kloss-Brandstätter
authors.affiliation: Department of Radiology, Maastricht University Medical Center, P. Debeyelaan 25, AZ 6202 Maastricht, The Netherlands.
authors.forename: Annika
authors.initials: A
authors.lastname: Stadler
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Maastricht University Medical Center, P. Debeyelaan 25, AZ 6202 Maastricht, The Netherlands.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Kross
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Miyagi, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Yamauchi
authors.affiliation: Department of Diagnostic and Interventional Radiology, University of Tuebingen, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany.
authors.forename: Dominik
authors.initials: D
authors.lastname: Ketelsen
authors.affiliation: Department of Cranio-Maxillofacial Surgery, Maastricht University Medical Center, P. Debeyelaan 25, AZ 6202 Maastricht, The Netherlands.
authors.forename: Peter
authors.initials: P
authors.lastname: Kessler
authors.affiliation: Department of Oral and Maxillofacial Surgery, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: blethaus@ukaachen.de.
authors.forename: Bernd
authors.initials: B
authors.lastname: Lethaus
mesh_terms: D044963:Biopsy, Fine-Needle / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003581:Cytodiagnosis / Q000295:instrumentation / Q000379:methods*; D004847:Epithelial Cells; D006801:Humans; D008198:Lymph Nodes; D008279:Magnetic Resonance Imaging; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D014463:Ultrasonography
keywords: Fine needle; Lymph node; MRI; Neck dissection; Oral carcinoma; Ultrasound