title: A 3D-continuum bidomain model of retinal electrical stimulation using an anatomically detailed mesh.
abstract: A continuum bidomain model of sub-retinal electrical stimulation on an anatomically detailed mesh of retina is presented. The underlying geometry is made up of 256 B-scans of optical coherence tomography (OCT) images of a healthy human retina, covering approximately 6×2 mm(2) centered on the macula. The OCT images are initially segmented and digitized into five major retinal layers comprising passive and active retinal cell types. This computational mesh is then used to model a subretinal hexapolar biphasic electrical stimulation. Our results indicate that the ultra-structure of the retina results in an asymmetric spatial extracellular potential distribution, leading to an irregular pattern of retinal ganglion cell activation. This finding is in contrast to focal circular activation previously reported in retinal electrical stimulation modeling with a uniform mesh.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Shalbaf
authors.forename: Peng
authors.initials: P
authors.lastname: Du
authors.forename: Nigel H
authors.initials: NH
authors.lastname: Lovell
authors.forename: Socrates
authors.initials: S
authors.lastname: Dokos
authors.forename: Ehsan
authors.initials: E
authors.lastname: Vaghefi
mesh_terms: D004558:Electric Stimulation; D006801:Humans; D021621:Imaging, Three-Dimensional; D008954:Models, Biological; D012160:Retina / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000502:physiology*; D041623:Tomography, Optical Coherence