title: Prototypes of Lanthanide(III) Agents Responsive to Enzymatic Activities in Three Complementary Imaging Modalities: Visible/Near-Infrared Luminescence, PARACEST-, and T1-MRI.
abstract: We report first prototypes of responsive lanthanide(III) complexes that can be monitored independently in three complementary imaging modalities. Through the appropriate choice of lanthanide(III) cations, the same reactive ligand can be used to form complexes providing detection by (i) visible (Tb(3+)) and near-infrared (Yb(3+)) luminescence, (ii) PARACEST- (Tb(3+), Yb(3+)), or (iii) T1-weighted (Gd(3+)) MRI. The use of lanthanide(III) ions of different natures for these imaging modalities induces only a minor change in the structure of complexes that are therefore expected to have a single biodistribution and cytotoxicity.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay , 1, av.de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Jiefang
authors.initials: J
authors.lastname: He
authors.affiliation: Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans , Rue Charles Sadron, F-45071 Orléans 2, France.
authors.forename: Célia S
authors.initials: CS
authors.lastname: Bonnet
authors.affiliation: Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans , Rue Charles Sadron, F-45071 Orléans 2, France.
authors.forename: Svetlana V
authors.initials: SV
authors.lastname: Eliseeva
authors.affiliation: Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans , Rue Charles Sadron, F-45071 Orléans 2, France.
authors.forename: Sara
authors.initials: S
authors.lastname: Lacerda
authors.affiliation: Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans , Rue Charles Sadron, F-45071 Orléans 2, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Chauvin
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay , 1, av.de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Retailleau
authors.affiliation: Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans , Rue Charles Sadron, F-45071 Orléans 2, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Szeremeta
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay , 1, av.de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Badet
authors.affiliation: Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans , Rue Charles Sadron, F-45071 Orléans 2, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Petoud
authors.affiliation: Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans , Rue Charles Sadron, F-45071 Orléans 2, France.
authors.forename: Éva
authors.initials: É
authors.lastname: Tóth
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay , 1, av.de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Durand
mesh_terms: D003287:Contrast Media / Q000737:chemistry; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008163:Luminescent Measurements / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D003287:Contrast Media; D028581:Lanthanoid Series Elements