title: Antimelanogenic activity of a novel adamantyl benzylbenzamide derivative, AP736: a randomized, double-blind, vehicle-controlled comparative clinical trial performed in patients with hyperpigmentation during the summer.
abstract: OBJECTIVE
  AP736 is a novel compound with an adamantyl benzylbenzamide moiety that has shown antimelanogenic activity in melanocytes in vitro and in artificial skin equivalent through the inhibition of key melanogenic enzymes and suppression of the cAMP-phosphokinase A-cAMP response element-binding protein signaling pathway. To estimate the clinical effectiveness of AP736 for the treatment of facial hyperpigmentation, we examined the efficacy and safety of a topical formulation containing AP736 compared with a vehicle formulation in human facial skin. To evaluate the degree of whitening when used in a real-life situation, subjects with hyperpigmentation conditions were selected and the trial was performed from mid-May to the end of June, when there are strong UV rays in Korea.
  
  
  METHODS
  Forty-eight healthy Korean women aged 20-60 years were enrolled in this study for 6 weeks. Women who were pregnant or undergoing any concurrent therapy were excluded. Subjects were instructed to apply a randomly assigned formulation containing 0.5% AP736 (test formulation; n = 24) or vehicle (vehicle control; n = 24) in addition to an assigned sunscreen with a twice-daily application protocol. The degree of facial pigmentation was measured objectively using a Mexameter MX18 and Chromameter CM700, in addition to assessment by physicians using clinical photographs.
  
  
  RESULTS
  The AP736 formulation was significantly (P < 0.05) more effective than the vehicle control formation in reducing the appearance of pigmentation at 3- and 6-week follow-up visits.
  
  
  CONCLUSIONS
  A formulation containing a novel skin whitening ingredient, AP736, effectively reduced pigmentation and was well tolerated by study subjects in summer season.
authors.affiliation: AMOREPACIFIC Corporation R&D Center, Yongin-si, Korea.|Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea.
authors.forename: Yeon Su
authors.initials: YS
authors.lastname: Jeong
authors.affiliation: AMOREPACIFIC Corporation R&D Center, Yongin-si, Korea.
authors.forename: Jeong-Hwan
authors.initials: JH
authors.lastname: Kim
authors.affiliation: AMOREPACIFIC Corporation R&D Center, Yongin-si, Korea.
authors.forename: Joonho
authors.initials: J
authors.lastname: Choi
authors.affiliation: AMOREPACIFIC Corporation R&D Center, Yongin-si, Korea.
authors.forename: Heung Soo
authors.initials: HS
authors.lastname: Baek
authors.affiliation: AMOREPACIFIC Corporation R&D Center, Yongin-si, Korea.
authors.forename: Yung Hyup
authors.initials: YH
authors.lastname: Joo
authors.affiliation: AMOREPACIFIC Corporation R&D Center, Yongin-si, Korea.
authors.forename: Chang Seok
authors.initials: CS
authors.lastname: Lee
authors.affiliation: AMOREPACIFIC Corporation R&D Center, Yongin-si, Korea.
authors.forename: Hong-Ju
authors.initials: HJ
authors.lastname: Shin
authors.affiliation: AMOREPACIFIC Corporation R&D Center, Yongin-si, Korea.
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Park
authors.affiliation: Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea.|Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Beom Joon
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: AMOREPACIFIC Corporation R&D Center, Yongin-si, Korea.
authors.forename: Song Seok
authors.initials: SS
authors.lastname: Shin
mesh_terms: D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000279:Administration, Cutaneous; D000328:Adult; D001549:Benzamides / Q000008:administration & dosage / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005148:Facial Dermatoses / Q000188:drug therapy*; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000188:drug therapy*; D008875:Middle Aged; D012621:Seasons; D013473:Sunscreening Agents / Q000008:administration & dosage; D055815:Young Adult
chemical_list: C000592311:5-adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide; D001549:Benzamides; D003879:Dermatologic Agents; D013473:Sunscreening Agents; D000218:Adamantane