title: [Value of serum IgA/C3 ratio in the diagnosis of IgA nephropathy and its correlation with the clinicopathological features].
abstract: OBJECTIVE
  To investigate the value of serum IgA/C3 ratio in the diagnosis of IgA nephropathy and explore its relationship with the clinicopathological features of the patients.
  
  
  METHODS
  Sixty-six patients with IgA nephropathy, 111 with other glomerular diseases, and 40 healthy control subjects without kidney disease were tested for serum IgA and C3 levels using CRM470 adjusted standardized immune turbidimetric method, and the IgA/C3 ratio was calculated. According to Oxford and Lee's classification criteria, we analyzed the pathological grades of the renal biopsy samples from patients with IgA nephropathy. The ROC curve was used to assess the value of serum IgA and IgA/C3 ratio in predicting IgA nephropathy.
  
  
  RESULTS
  Patients with IgA nephropathy had an elevated serum IgA/C3 ratio than those with other glomerular diseases and the control subjects, with an area under the ROC curve of 0.776. An elevated serum IgA/C3 ratio was not found to significantly correlate with the pathological grade of renal biopsy samples in patients with IgA nephropathy.
  
  
  CONCLUSIONS
  In the absence of renal biopsy findings, serum IgA/C3 ratio can help in the diagnosis of IgA nephropathy.
authors.affiliation: Institute of Nephrology and Urology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. E-mail: zhushuang101@126.com.
authors.forename: Shuangshuang
authors.initials: S
authors.lastname: Zhu
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Li
authors.forename: Shulu
authors.initials: S
authors.lastname: Zhou
authors.forename: Qingzhu
authors.initials: Q
authors.lastname: Wei
authors.forename: Kangping
authors.initials: K
authors.lastname: Deng
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Jianghuan
authors.initials: J
authors.lastname: Liu
authors.forename: Xinyu
authors.initials: X
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Shao
authors.forename: Aiqun
authors.initials: A
authors.lastname: Liu
authors.forename: Bifang
authors.initials: B
authors.lastname: Wu
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Zhao
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Xu
authors.forename: Hanfei
authors.initials: H
authors.lastname: Lin
authors.forename: Qin
authors.initials: Q
authors.lastname: Liu
authors.forename: Jiamin
authors.initials: J
authors.lastname: Li
authors.forename: Honglei
authors.initials: H
authors.lastname: Wang
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhou
authors.forename: Chaoya
authors.initials: C
authors.lastname: Zhu
authors.forename: Daoyuan
authors.initials: D
authors.lastname: Lv
authors.forename: Yue
authors.initials: Y
authors.lastname: Xia
authors.forename: Hequn
authors.initials: H
authors.lastname: Zou
mesh_terms: D001706:Biopsy; D016022:Case-Control Studies; D003176:Complement C3 / Q000032:analysis*; D005922:Glomerulonephritis, IGA / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007668:Kidney / Q000473:pathology
chemical_list: D003176:Complement C3; D007070:Immunoglobulin A