title: Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease.
abstract: The single-stranded nucleic acid-binding protein KHSRP (KH-type splicing regulatory protein) modulates RNA life and gene expression at various levels. KHSRP controls important cellular functions as different as proliferation, differentiation, metabolism, and response to infectious agents. We summarize and discuss experimental evidence providing a potential link between changes in KHSRP expression/function and human diseases including neuromuscular disorders, obesity, type II diabetes, and cancer.
authors.affiliation: Gene Expression Regulation Laboratory, IRCCS AOU San Martino-IST, Genova, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Briata
authors.affiliation: Gene Expression Regulation Laboratory, IRCCS AOU San Martino-IST, Genova, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Bordo
authors.affiliation: Gene Expression Regulation Laboratory, IRCCS AOU San Martino-IST, Genova, Italy.
authors.forename: Margherita
authors.initials: M
authors.lastname: Puppo
authors.affiliation: S.C. Ginecologia e Ostetricia Galliera Hospital, Genova, Italy.|School of Medicine, DINOGMI, University of Genova, Genova, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Gorlero
authors.affiliation: Gene Expression Regulation Laboratory, IRCCS AOU San Martino-IST, Genova, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Rossi
authors.affiliation: Department of Neurosciences, School of Medicine, University of New Mexico, Albuquerque, NM, USA.
authors.forename: Nora
authors.initials: N
authors.lastname: Perrone-Bizzozero
authors.affiliation: Gene Expression Regulation Laboratory, IRCCS AOU San Martino-IST, Genova, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Gherzi
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004198:Disease Susceptibility; D005786:Gene Expression Regulation; D006801:Humans; D056747:Immunomodulation; D050356:Lipid Metabolism; D024510:Muscle Development; D009132:Muscles / Q000502:physiology; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D015534:Trans-Activators / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014777:Virus Diseases / Q000276:immunology / Q000378:metabolism / Q000821:virology
chemical_list: C105789:KHSRP protein, human; D016601:RNA-Binding Proteins; D015534:Trans-Activators