title: Silver nanoparticles well-dispersed in amine-functionalized, one-pot made vesicles as an effective antibacterial agent.
abstract: We report a simple route to prepare silver nanoparticle (Ag NP) loaded amine functionalized poly-oligomeric (ethylene glycol) methyl ether methacrylate block poly-glycidyl methacrylate (POEGMA-b-PGMA) vesicles as an effective antibacterial agent. Self-assemblies of POEGMA-b-PGMA were prepared from reversible addition-fragmentation chain transfer (RAFT) dispersion polymerization mediated by a POEGMA macro-chain transfer agent (macro-CTA) in ethanol. Amine-functionalized self-assemblies were applied for Ag NP loading by using amine and hydroxyl groups as both the coordination agent and reductant under hydrothermal condition in high-pressure steam sterilization. 12.7 wt.% content of fine Ag NP well-dispersed in vesicles showed excellent antibacterial activities with the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) below 5.0 and 10.0 mg/L against Escherichia coli and 2.5 and 80 mg/L against Staphylococcus aureus respectively.
authors.affiliation: Shenzhen Key Laboratory of Special Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
authors.forename: Yuanming
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Shenzhen Key Laboratory of Special Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
authors.forename: Jiefeng
authors.initials: J
authors.lastname: Li
authors.affiliation: Shenzhen Key Laboratory of Special Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
authors.forename: Junyan
authors.initials: J
authors.lastname: Yu
authors.affiliation: Shenzhen Key Laboratory of Special Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
authors.forename: Jinlai
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Shenzhen Key Laboratory of Special Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China. Electronic address: tjn@szu.edu.cn.
authors.forename: Jiaoning
authors.initials: J
authors.lastname: Tang
mesh_terms: D000588:Amines / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D053768:Metal Nanoparticles / Q000737:chemistry*; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000588:Amines; D000900:Anti-Bacterial Agents; D012834:Silver
keywords: Antibacterial; Nanocomposites; Nanoparticles; RAFT dispersion polymerization; Self-assemblies; Silver