title: Success of an International Learning Health Care System in Hematopoietic Cell Transplantation: The American Society of Blood and Marrow Transplantation Clinical Case Forum.
abstract: The American Society for Blood and Marrow Transplantation (ASBMT) Clinical Case Forum (CCF) was launched in 2014 as an online secure tool to enhance interaction and communication among hematopoietic cell transplantation (HCT) professionals worldwide through the discussion of challenging clinical care issues. After 14 months, we reviewed clinical and demographical data of cases posted in the CCF from January 29, 2014 to March 18, 2015. A total of 137 cases were posted during the study period. Ninety-two cases (67%) were allogeneic HCT, 29 (21%) were autologous HCT, and in 16 (12%), the type of transplantation (autologous versus allogeneic) was still under consideration. The diseases most frequently discussed included non-Hodgkin lymphoma (NHL; n = 30, 22%), acute myeloid leukemia (n = 23, 17%), and multiple myeloma (MM; n = 20, 15%). When compared with the US transplantation activity reported by the US Department of Health and Human Services, NHL and acute lymphoblastic leukemia cases were over-represented in the CCF, whereas MM was under-represented (P < .001). A total of 259 topics were addressed in the CCF with a median of 2 topics/case (range, 1 to 6). Particularly common topics included whether transplantation was indicated (n = 57, 41%), conditioning regimen choice (n = 44, 32%), and post-HCT complications after day 100 (n = 43, 31%). The ASBMT CCF is a successful tool for collaborative discussion of complex cases in the HCT community worldwide and may allow identification of areas of controversy or unmet need from clinical, educational and research perspectives.
authors.affiliation: Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York.|Hematology Department. Hospital Universitario Vall d'Herbon-Universidad Autonoma de Barcelona.
authors.forename: Pere
authors.initials: P
authors.lastname: Barba
authors.affiliation: National Marrow Donor Program, University of Minnesota, Minneapolis, Minnesota.
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Burns
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Litzow
authors.affiliation: Department of Medicine, University of Wisconsin, Madison, Wisconsin.
authors.forename: Mark B
authors.initials: MB
authors.lastname: Juckett
authors.affiliation: Adult Stem Cell Transplant Program, University of Miami Sylvester Cancer Center, Miami, Florida.
authors.forename: Krishna V
authors.initials: KV
authors.lastname: Komanduri
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Devlin
authors.affiliation: University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Luciano J
authors.initials: LJ
authors.lastname: Costa
authors.affiliation: Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: Shakila
authors.initials: S
authors.lastname: Khan
authors.affiliation: Department of Medicine, American Society of Blood and Marrow Transplantation, Tufts Medical Center, Boston, Massachusetts.
authors.forename: Andrea
authors.initials: A
authors.lastname: King
authors.affiliation: Divison of Hematology/Oncology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts.
authors.forename: Andreas
authors.initials: A
authors.lastname: Klein
authors.affiliation: Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California.
authors.forename: Amrita
authors.initials: A
authors.lastname: Krishnan
authors.affiliation: The Mount Sinai Medical Center, New York, New York.
authors.forename: Adriana
authors.initials: A
authors.lastname: Malone
authors.affiliation: Penn State Hershey Cancer Institute, Hershey, Pennsylvania.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Mir
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Carina
authors.initials: C
authors.lastname: Moravec
authors.affiliation: Department of Medicine/Hematology-Oncology, University of Oklahoma, Oklahoma City, Oklahoma.
authors.forename: George
authors.initials: G
authors.lastname: Selby
authors.affiliation: Hematology-Oncology Division, Mayo Clinic, Jacksonville, Florida.
authors.forename: Vivek
authors.initials: V
authors.lastname: Roy
authors.affiliation: Stem Cell Transplant Program, Dana-Farber Cancer Institute, Boston, Massachusetts.
authors.forename: Melissa
authors.initials: M
authors.lastname: Cochran
authors.affiliation: Blood and Marrow Transplant Program, University of Minnesota.
authors.forename: Melisa K
authors.initials: MK
authors.lastname: Stricherz
authors.affiliation: The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Westmoreland
authors.affiliation: Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Miguel-Angel
authors.initials: MA
authors.lastname: Perales
authors.affiliation: Division of Hematology/Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina. On behalf of the ASBMT Committee on Education.
authors.forename: William A
authors.initials: WA
authors.lastname: Wood
mesh_terms: D064591:Allografts; D064592:Autografts; D019337:Hematologic Neoplasms / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D012955:Societies, Medical; D014481:United States
keywords: Allogeneic hematopoietic stem cell transplantation; Autologous stem cell transplantation; Case discussions