title: [Tobacco smoking as a cofactor for the development of cervical cancer].
abstract: Etiopathogenesis of cervical cancer is mainly related to persistent HPV infection. However in neoplastic transformation participate additional factors, one of the main is tobacco smoking. Nowadays, in Poland is conduced prophylactic program with the target to decrease incidence and mortality according to cervical cancer. The basis of this program is Pap smears, histological diagnostics and colposcopy.
  
  
  OBJECTIVE
  The aim of this paper was evaluation of correlation between histopatological changes uterin cervix in respect of tobacco smoking and immunohistochemistry LI capsid protein test.
  
  
  METHODS
  From 3520 patients with incorrect Pap smears selected 36 cases (medium age 36) with incorrect Pap smears and histology. Used immunohistochemical methods (with HRP system) for evaluation of L1 protein.
  
  
  RESULTS
  In group with positive L1 test significant part were smokers and those who quite smoking. The results revealed directly relate between cigarette.
authors.forename: Dagmara
authors.initials: D
authors.lastname: Jabłonowska-Fudzińska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Marszałek
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Szylberg
mesh_terms: D000328:Adult; D003127:Colposcopy; D015897:Comorbidity; D005260:Female; D006801:Humans; D065006:Papanicolaou Test; D030361:Papillomavirus Infections / Q000453:epidemiology*; D011044:Poland / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D014626:Vaginal Smears