title: [Drop in suicide rate after first psychosis: a comparison with the situation two decades ago].
abstract: OBJECTIVE
  Over two decades ago a study reported that a percentage as high as 11% of the patients with a psychotic disorder in the northern Netherlands died by committing suicide. The primary objective of the current study was to replicate these findings in the same geographical area. A secondary objective was to investigate potential predictors of suicide.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  From patient files we identified the current status of all patients who experienced their first episode of psychosis and participated in the Psychosis Recent Onset Groningen-Survey (PROGR-S) between 2000 and 2009. The PROGR-S is a diagnostic protocol for persons with suspected first psychosis. Kaplan-Meier survival analysis was used to identify the current suicide risk in this group and this was compared with the 1973-1988 patients using a log rank test. We also determined the standardized mortality rate in relation to the general population. Cox regression analysis was used to assess significant predictors of suicide.
  
  
  RESULTS
  The suicide risk dropped drastically over the course of two decades from 11% to 2.4%. Older age was the strongest predictor of suicide. The standardized mortality rate was 41.6.
  
  
  CONCLUSIONS
  Despite the significant decline in suicide after a first episode of psychosis, the risk of suicide should be given the highest priority in psychiatric psychosis care, as it is very high at 4162% compared with the suicide risk in general population.
authors.affiliation: *Dit onderzoek werd eerder gepubliceerd in PLoS One (2015;10:e0129263) met als titel 'Suicide in recent onset psychosis revisited: significant reduction of suicide rate over the last two decades - a replication study of a Dutch incidence cohort'. Afgedrukt met toestemming.
authors.forename: Stynke
authors.initials: S
authors.lastname: Castelein
authors.forename: Edith J
authors.initials: EJ
authors.lastname: Liemburg
authors.forename: Jill S
authors.initials: JS
authors.lastname: de Lange
authors.forename: Frank  D
authors.initials: F
authors.lastname: van Es
authors.forename: Ellen
authors.initials: E
authors.lastname: Visser
authors.forename: André
authors.initials: A
authors.lastname: Aleman
authors.forename: Richard
authors.initials: R
authors.lastname: Bruggemans
authors.forename: Henderikus
authors.initials: H
authors.lastname: Knegtering