title: Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis.
abstract: The role of GRK4 and DRD1 genes in hypertension remains controversial. We performed a meta-analysis to determine whether GRK4 and DRD1 polymorphisms influence the risk of hypertension and examined the relationship between the genetic variances and the etiology of hypertension. Relevant case-control studies were retrieved by database searches and selected according to established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. Meta-regression, subgroup analysis, and sensitivity analysis were performed. A total of 15 articles containing 29 studies were finally included. In the dominant model, rs4532 locus of DRD1 gene was related to hypertension with a pooled OR of 1.353 (95% CI =1.016-1.802, P=0.038). Subgroup analysis for ethnicity showed that rs1024323 locus of GRK4 gene was associated with hypertension in Caucasians (OR =1.826, 95% CI =1.215-2.745, P=0.004) but not in East Asians and Africans. Rs4532 locus was associated with hypertension in East Asians (OR =1.833, 95% CI =1.415-2.376, P,0.001) but not in Caucasians. These data provide possible references for future case-control studies in hypertension.
authors.affiliation: Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
authors.forename: He
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
authors.forename: Zhao-qing
authors.initials: ZQ
authors.lastname: Sun
authors.affiliation: Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
authors.forename: Shuang-shuang
authors.initials: SS
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
authors.forename: Li-na
authors.initials: LN
authors.lastname: Yang
mesh_terms: D044466:Asian People / Q000235:genetics; D054771:G-Protein-Coupled Receptor Kinase 4 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C583260:DRD1 protein, human; D017447:Receptors, Dopamine D1; D054771:G-Protein-Coupled Receptor Kinase 4; C517855:GRK4 protein, human
keywords: DRD1; GRK4; gene polymorphism; hypertension; meta-analysis