title: Legionella pneumophila, armed to the hilt: justifying the largest arsenal of effectors in the bacterial world.
abstract: Many bacterial pathogens use dedicated translocation systems to deliver arsenals of effector proteins to their hosts. Once inside the host cytosol, these effectors modulate eukaryotic cell biology to acquire nutrients, block microbial degradation, subvert host defenses, and enable pathogen transmission to other hosts. Among all bacterial pathogens studied to date, the gram-negative pathogen, Legionella pneumophila, maintains the largest arsenal of effectors, with over 330 effector proteins translocated by the Dot/Icm type IVB translocation system. In this review, I will discuss some of the recent work on understanding the consequences of this large arsenal. I will also present several models that seek to explain how L. pneumophila has acquired and subsequently maintained so many more effectors than its peers.
authors.affiliation: Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Public Health Ontario, Toronto, Ontario M5G 1M1, Canada. Electronic address: alex.ensminger@utoronto.ca.
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Ensminger
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D058947:Bacterial Secretion Systems / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism; D003600:Cytosol / Q000382:microbiology; D016680:Genome, Bacterial; D054884:Host-Pathogen Interactions / Q000502:physiology; D016952:Legionella pneumophila / Q000378:metabolism / Q000472:pathogenicity*; D007877:Legionnaires' Disease / Q000382:microbiology*; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D021381:Protein Transport
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems; D002352:Carrier Proteins; D008565:Membrane Proteins