title: BRIP1, a potential candidate gene in development of non-BRCA1/2 breast cancer.
abstract: BRIP1 encodes a protein belonging to the RecQ DEAH helicase family. It interacts with BRCA1, and is involved in the repair of DNA damage and tumor suppression. Aberrations in BRIP1 have been mainly associated with the development of breast cancer (BC), ovarian cancer, and type J Fanconi anemia. Based on recent work, we hypothesize that BRIP1 might be the gene involved in the onset of BC in families that do not show BRACA1/2 mutations. This review will focus on the findings supporting this hypothesis, the mechanisms linking BRIP1 to the onset of BC, and the potential clinical relevance of its various inhibitors.
authors.affiliation: Department of Biological and Environmental Sciences, College of Arts & Sciences, Qatar University, Qatar, aet74@cornell.edu.
authors.forename: Allal
authors.initials: A
authors.lastname: Ouhtit
authors.affiliation: Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman.
authors.forename: Ishita
authors.initials: I
authors.lastname: Gupta
authors.affiliation: Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate of Oman.
authors.forename: Zoya
authors.initials: Z
authors.lastname: Shaikh
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D051856:Fanconi Anemia Complementation Group Proteins; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006801:Humans; D020365:RNA Helicases / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D051856:Fanconi Anemia Complementation Group Proteins; C000618935:BRIP1 protein, human; D020365:RNA Helicases