title: A Randomized, Controlled Trial to Assess the Efficacy of Arthroscopic Debridement in Combination with Oral Medication Versus Oral Medication in Patients with Gouty Knee Arthritis.
abstract: Gouty knee arthritis refers to a form of inflammatory diseases caused by deposits of needle-like crystals of uric acid in knee joint. The aim of this study was to assess the efficacy and safety of arthroscopic debridement in combination with oral medication versus oral medication alone for the treatment of gouty knee arthritis. A total of 60 patients with gouty knee arthritis were randomized to receive either arthroscopic surgery in combination with oral medication or oral medication alone. Efficacy was assessed with the angle of motion, functions, and visual analog scale (VAS). These indices were measured prior to treatment and at 2, 4, 12, 24, and 48 weeks posttreatment. Surgery- and medication-related complications were observed. Significant differences in flexion and extension of the knee joint, lymphoma scores, and VAS were detected between the two groups at 2, 4, and 12 weeks posttreatment (P < 0.05) but not at weeks 24 and 48 posttreatment (P > 0.05) . Significant differences in these indices were detected at different time points in each group (P < 0.05), except between weeks 24 and 48 (P > 0.05). Arthroscopic surgery in combination with oral medication is superior to single oral medication in the flexion and extension of the knee joint, lymphoma scores, and pain relief (VAS) before 24 weeks, although no statistical differences were detected in the efficacy after 24 weeks, and in medication-related safety between the two groups. Although arthroscopic debridement cannot replace systemic uric acid-lowering treatments such as medication and dietary control, it is still an effective approach.
authors.affiliation: First Clinical Medical College of Lanzhou University, the First Hospital of Lanzhou University, Dong Gang West Road, No. 199, Lanzhou, 730000 Gansu China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: The Second Hospital of Lanzhou University, Cui Ying Men, Lanzhou, 730030 Gansu China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Wanyan
authors.affiliation: The First Hospital of Lanzhou University, Dong Gang West Road, No. 199, Lanzhou, 730000 Gansu China.
authors.forename: Jian Min
authors.initials: JM
authors.lastname: Wang
authors.affiliation: Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Dong Gang West Road, No. 199, Lanzhou, 730000 Gansu China.
authors.forename: Jin Hui
authors.initials: JH
authors.lastname: Tian
authors.affiliation: Orthopedics Department, The First Hospital of Lanzhou University, Lanzhou, Gansu China.
authors.forename: Long
authors.initials: L
authors.lastname: Hu
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu China.
authors.forename: Xi Ping
authors.initials: XP
authors.lastname: Shen
authors.affiliation: Evidence-Based Medicine Center, The First Clinical Medical College of Lanzhou University, Dong Gang West Road, No. 199, Lanzhou, 730000 Gansu China.
authors.forename: Ke Hu
authors.initials: KH
authors.lastname: Yang
keywords: Arthroscopic debridement; Gouty knee arthritis; Randomized controlled trial