title: Regression of Fibroadenomas with Centchroman: a Randomized Controlled Trial.
abstract: Fibroadenoma is a common cause of breast lump in young girls. Nearly 10-15 % of lesions regress spontaneously over the period of 6 to 60 months. The aim of study was to investigate the role of Centchroman in regression of fibroadenoma in comparison to natural observation and to study the association of hormonal receptors with degree of regression. The study was carried out at the outpatient clinic of Department of Surgery, All India Institute of Medical Sciences, New Delhi, from November 2004 to November 2007. Patients aged ≤30 years with fibroadenoma were included. Patients with fibroadenoma equal to or larger than 5 cm and with polycystic ovarian disease were excluded. Patients were randomized in two groups. Patients in active therapy arm were prescribed Centchroman 30 mg daily for 12 weeks, and another group was observed without any intervention (control group). Patients were followed at weeks 4, 8, 12, and 24 to assess response to therapy. Twenty-two (31.88 %) fibroadenomas in Centchroman arm disappeared completely as compared to four (7.69 %) in control arm over a period of 6 months. There was a decrease in the volume of fibroadenoma in ten (19.23 %) patients in control arm and 36 (52.17 %) patients in Centchroman arm. Centchroman therapy allowed 31 % fibroadenoma to regress completely with scanty menses or amenorrhea as the only side effect.
authors.affiliation: SMS Medical College, Jaipur, India.
authors.forename: Prakash Laxmichand
authors.initials: PL
authors.lastname: Tejwani
authors.affiliation: All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Hrishikesh
authors.initials: H
authors.lastname: Nerkar
authors.affiliation: All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Anita
authors.initials: A
authors.lastname: Dhar
authors.affiliation: All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Kamal
authors.initials: K
authors.lastname: Kataria
authors.affiliation: All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Smriti
authors.initials: S
authors.lastname: Hari
authors.affiliation: All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Thulkar
authors.affiliation: All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Chumber
authors.affiliation: All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Sunesh
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Surgical Disciplines, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029 India.
authors.forename: Anurag
authors.initials: A
authors.lastname: Srivastava
keywords: Antiestrogen; Centchroman; Fibroadenoma; Hormone receptor; Polycystic ovarian disease; Saheli