title: Heme metabolism in stress regulation and protein production: From Cinderella to a key player.
abstract: Heme biosynthesis is a highly conserved pathway which is present in all kingdoms, from Archaea to higher organisms such as plants and mammals. The heme molecule acts as a prosthetic group for different proteins and enzymes involved in energy metabolism and reactions involved in electron transfer. Based on our recent findings and other recent reports, we here illustrate that heme is more than a co-factor. We also discuss the necessity to gain more insight into the heme biosynthesis pathway regulation, as this interacts closely with overall stress control. Understanding heme biosynthesis and its regulation could impact our ability to develop more efficient yeast cell factories for heterologous protein production.
authors.affiliation: a Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology , Gothenburg , Sweden.|b Department of Biology and Biological Engineering , Chalmers University of Technology , Göteborg , Sweden.
authors.forename: J L
authors.initials: JL
authors.lastname: Martínez
authors.affiliation: a Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology , Gothenburg , Sweden.|b Department of Biology and Biological Engineering , Chalmers University of Technology , Göteborg , Sweden.
authors.forename: D
authors.initials: D
authors.lastname: Petranovic
authors.affiliation: a Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology , Gothenburg , Sweden.|b Department of Biology and Biological Engineering , Chalmers University of Technology , Göteborg , Sweden.|c Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , Hørsholm , Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Nielsen
mesh_terms: D000818:Animals; D001105:Archaea / Q000378:metabolism; D006418:Heme / Q000096:biosynthesis*; D010944:Plants / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
chemical_list: D029701:Saccharomyces cerevisiae Proteins; D006418:Heme
keywords: Hap1; cell stress; heme biosynthesis; protein production; yeast cell factories