title: Antiplasmodial Limonoids from Trichilia rubescens (Meliaceae).
abstract: Two new limonoids, named rubescins D-E (1-2) along with eight known compounds, including five havanensin type limonoids, TS1 (3), TS3 (4), rubescins A-C (5-7) and three known phytosterols, β-sitosterol, stigmasterol and its 3β-O-glucopyranoside derivative were isolated from the roots and stem bark of Trichilia rubescens, collected from Cameroon. The structures of the new compounds were determined by detailed analyses of 1D and 2D NMR spectra, in combination with high-resolution mass spectrometry data and by comparison with related data from literature. Anti-plasmodial activities of some of the isolated limonoids 1, 2, 4, 6 and 7 were evaluated against erythrocytic stages of strain 3D7 Plasmodium falciparum. Compounds 2 and 4 exhibited significant anti-plasmodial in vitro activity with IC50 values of 1.13 and 0.79 μM, respectively.
authors.forename: Tsamo T
authors.initials: TT
authors.lastname: Armelle
authors.forename: Nangmo K
authors.initials: NK
authors.lastname: Pamela
authors.forename: Mkounga
authors.initials: M
authors.lastname: Pierre
authors.forename: Ingrid B
authors.initials: IB
authors.lastname: Müller
authors.forename: Kirk
authors.initials: K
authors.lastname: Marat
authors.forename: Gabriele
authors.initials: G
authors.lastname: Sass
authors.affiliation: Department of Organic Chemistry, University of Yaounde I, P.O. Box 812 Yaounde, Cameroon. ankengf@yahoo.fr.
authors.forename: Nkengfack A
authors.initials: NA
authors.lastname: Ephrem
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D020128:Inhibitory Concentration 50; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029582:Meliaceae / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D000962:Antimalarials; D036701:Limonins