title: Favorable outcomes in octogenarians treated with bioresorbable polymer drug-eluting stent.
abstract: OBJECTIVE
  As a result of a higher prevalence of comorbidities, elderly adults are often underrepresented in clinical trials, and more often experience complications during percutaneous coronary intervention. Our aim was to evaluate clinical outcomes of patients older than 80 years, compared with their younger counterparts, when bioresorbable polymer biolimus A9 drug-eluting stent is used for their treatment.
  
  
  METHODS
  The prospective, observational e-Nobori registry was created to validate the safety and efficacy of bioresorbable polymer drug-eluting stent in unselected patients. The primary end-point of the study was freedom from target lesion failure defined as a composite of cardiac death, target vessel-related myocardial infarction and clinically-driven target lesion revascularization at 1 year.
  
  
  RESULTS
  There were 781 (7.8%) octogenarians, they were less frequently male (62% vs 77%; P < 0.0001) and more often presented as acute coronary syndrome (44% vs 39%; P = 0.0182). The index percutaneous coronary intervention success was lower in the elderly patients (98% vs 99%; P = 0.0398). One-year follow up was completed for 97% of the elderly patients and 99% of the younger patients. The difference in target lesion failure (3.33% vs 2.83%; log-rank P = 0.0114) was mainly driven by increased mortality in octogenarians (3.73% vs 1.47%; P < 0.0001). Elderly patients had more bleeding and vascular complications (2.67% vs 1.05%; P = 0.0001).
  
  
  CONCLUSIONS
  Despite advanced age, multiple comorbidities and complexity of treated lesions, clinical outcomes are favorable in octogenarians treated by bioresorbable polymer biolimus A9 drug-eluting stent. Geriatr Gerontol Int 2016; 16: 1246-1253.
authors.affiliation: Department of Cardiology, Clinical Hospital Centre Zemun, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Ilic
authors.affiliation: Department of Cardiology, Clinical Hospital Centre Zemun, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Stankovic
authors.affiliation: Department of Cardiology, Clinical Hospital Centre Zemun, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Bojan
authors.initials: B
authors.lastname: Ilisic
authors.affiliation: Department of Cardiology, Clinical Hospital Centre Zemun, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Milivoje
authors.initials: M
authors.lastname: Cerovic
authors.affiliation: Department of Cardiology, Clinical Hospital Centre Zemun, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Aleksic
authors.affiliation: Department of Cardiology, Clinical Hospital Centre Zemun, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Ivica
authors.initials: I
authors.lastname: Nikolajevic
authors.affiliation: Department of Cardiology, Clinical Hospital Centre Zemun, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Srdjan
authors.initials: S
authors.lastname: Kafedzic
authors.affiliation: Cardiology, Hospital de León, León, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Cuellas Ramon
authors.affiliation: Cardiology, Ukrainian Institute of Cardiology, Kiev, Ukraine.
authors.forename: Maxim
authors.initials: M
authors.lastname: Sokolov
authors.affiliation: Cardiology, Om El-kora Cardiac Center, Gharbia, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El Setecha
authors.affiliation: Department of Cardiology, Clinical Hospital Centre Zemun, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Biljana
authors.initials: B
authors.lastname: Putnikovic
authors.affiliation: Department of Cardiology, Clinical Hospital Centre Zemun, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Aleksandar N
authors.initials: AN
authors.lastname: Neskovic
mesh_terms: D020341:Absorbable Implants; D000369:Aged, 80 and over; D054855:Drug-Eluting Stents; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000628:therapy*; D062645:Percutaneous Coronary Intervention; D011108:Polymers; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D011108:Polymers
keywords: 80 and older; aged; biolimus A9; drug-coated stent; percutaneous coronary intervention