title: Sexual transmission of Trypanosoma cruzi in murine model.
abstract: Trypanosoma cruzi is mainly transmitted by blood-sucking triatomines, but other routes also have epidemiological importance, such as blood transfusion and congenital transmission. Although the possibility of sexual transmission of T. cruzi has been suggested since its discovery, few studies have been published on this subject. We investigated acquisition of T. cruzi by sexual intercourse in an experimental murine model. Male and female mice in the chronic phase of Chagas disease were mated with naive partners. Parasitological, serological and molecular tests demonstrated the parasites in tissues and blood of partners. These results confirm the sexual transmission of T. cruzi in mice.
authors.affiliation: Interdisciplinary Laboratory of Biosciences, Faculty of Medicine, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasília, Federal District 70.910-900, Brazil.
authors.forename: Marcelle
authors.initials: M
authors.lastname: Ribeiro
authors.affiliation: Interdisciplinary Laboratory of Biosciences, Faculty of Medicine, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasília, Federal District 70.910-900, Brazil.
authors.forename: Nadjar
authors.initials: N
authors.lastname: Nitz
authors.affiliation: Interdisciplinary Laboratory of Biosciences, Faculty of Medicine, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasília, Federal District 70.910-900, Brazil.
authors.forename: Camilla
authors.initials: C
authors.lastname: Santana
authors.affiliation: Interdisciplinary Laboratory of Biosciences, Faculty of Medicine, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasília, Federal District 70.910-900, Brazil.
authors.forename: Aline
authors.initials: A
authors.lastname: Moraes
authors.affiliation: Interdisciplinary Laboratory of Biosciences, Faculty of Medicine, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasília, Federal District 70.910-900, Brazil.
authors.forename: Luciana
authors.initials: L
authors.lastname: Hagström
authors.affiliation: Interdisciplinary Laboratory of Biosciences, Faculty of Medicine, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasília, Federal District 70.910-900, Brazil.
authors.forename: Rafael
authors.initials: R
authors.lastname: Andrade
authors.affiliation: Interdisciplinary Laboratory of Biosciences, Faculty of Medicine, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasília, Federal District 70.910-900, Brazil.
authors.forename: Adriano
authors.initials: A
authors.lastname: Rios
authors.affiliation: Interdisciplinary Laboratory of Biosciences, Faculty of Medicine, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasília, Federal District 70.910-900, Brazil.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sousa
authors.affiliation: Laboratory of Animal Welfare, Brasília, Federal District 70.910-900, Brazil.
authors.forename: Bruno
authors.initials: B
authors.lastname: Dallago
authors.affiliation: Laboratory of Medical Parasitology and Vector Biology, Faculty of Medicine, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasília, Federal District 70.910-900, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Gurgel-Gonçalves
authors.affiliation: Interdisciplinary Laboratory of Biosciences, Faculty of Medicine, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasília, Federal District 70.910-900, Brazil. Electronic address: marianahecht@gmail.com.
authors.forename: Mariana
authors.initials: M
authors.lastname: Hecht
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D000953:Antigens, Protozoan / Q000276:immunology; D014355:Chagas Disease / Q000469:parasitology / Q000473:pathology / Q000635:transmission*; D016054:DNA, Protozoan / Q000032:analysis / Q000097:blood / Q000302:isolation & purification; D004195:Disease Models, Animal; D005260:Female; D006066:Gonads / Q000469:parasitology; D006321:Heart / Q000469:parasitology; D007422:Intestines / Q000469:parasitology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018482:Muscle, Skeletal / Q000469:parasitology; D059208:Parasite Load; D012749:Sexually Transmitted Diseases / Q000469:parasitology / Q000473:pathology / Q000635:transmission*; D014349:Trypanosoma cruzi / Q000235:genetics / Q000276:immunology / Q000502:physiology*
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D016054:DNA, Protozoan
keywords: Chronic Chagas disease; Murine model; Sexual transmission; Trypanosoma cruzi