title: A new flavone C-glycoside and a new bibenzyl from Bulbophyllum retusiusculum.
abstract: A new flavone C-glycoside, apigenin 6-C-α-arabinofuranosyl 8-C-α-arabinopyranoside (1) and a new bibenzyl, bulbotetusine (2), were isolated from the tubers of Bulbophyllum retusiusculum. Their structures were established on the basis of extensive spectroscopic analyses. The absolute configuration of 2 was determined by the comparison of experimental and calculated electronic circular dichroism. Compounds 1 and 2 showed no obvious cytotoxic activity against any five human tumour cell lines with IC50 values >40 μM.
authors.affiliation: a School of Pharmaceutical Sciences and Chemistry , Dali University , Dali , P.R. China.|b Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming , P.R. China.
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Yang
authors.affiliation: b Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming , P.R. China.|c School of Chemical Science and Technology , Kunming University , Kunming , P.R. China.
authors.forename: Yun-Shan
authors.initials: YS
authors.lastname: Fang
authors.affiliation: b Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming , P.R. China.
authors.forename: Le
authors.initials: L
authors.lastname: Cai
authors.affiliation: b Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming , P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: b Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming , P.R. China.
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Dong
authors.affiliation: b Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming , P.R. China.
authors.forename: Tian-Peng
authors.initials: TP
authors.lastname: Yin
authors.affiliation: b Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming , P.R. China.
authors.forename: Cai-Li
authors.initials: CL
authors.lastname: Huang
authors.affiliation: b Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming , P.R. China.
authors.forename: Zhong-Tao
authors.initials: ZT
authors.lastname: Ding
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D047310:Apigenin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001632:Bibenzyls / Q000737:chemistry / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008968:Molecular Conformation; D029595:Orchidaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D035281:Plant Tubers / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001632:Bibenzyls; D006027:Glycosides; D010936:Plant Extracts; C000617305:bulbotetusine; C000617454:flavone C-glycoside, apigenin 6-C-alpha-arabinofuranosyl 8-C-alpha-arabinopyranoside; D047310:Apigenin
keywords: Bulbophyllum retusiusculum; apigenin 6-C-α-arabinofuranosyl 8-C-α-arabinopyranoside; bibenzyl; bulbotetusine; flavone C-glycoside