title: Chromophobe renal cell carcinoma, eosinophilic variant with papillary growth: a case report.
abstract: We report the case of an 80-year-old man who presented with pathologically diagnosed chromophobe renal cell carcinoma composed of eosinophilic cells with partial papillary growth. The patient had a 2.5 cm diameter renal mass incidentally detected by abdominal ultrasound examination. Laparoscopic left partial nephrectomy was performed under a diagnosis of left renal tumor. Histopathology demonstrated uniform eosinophilic cuboidal cells growing with a partially papillary pattern: differential diagnosis of oncocytoma, papillary renal cell carcinoma, or oncocytic papillary renal cell carcinoma was necessary. Immunohistochemical staining with anti-monoclonal antibody 31 and -CD82 antibody, and choroid iron staining, were positive. Cytogenetic analysis by comparative genomic hybridization showed gains of chromosomes 1p, 9q, 19q, 20, and 21q, and losses of chromosomes 1p and q, 2q, 6q and 7q, leading to diagnosis of chromophobe RCC. We describe differential diagnosis for chromophobe renal cell carcinoma, eosinophilic variant, growing in a papillary fashion in the kidney.
authors.affiliation: Department of Urology, Kochi Medical School Nankoku 783-8505, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Karashima
authors.affiliation: Department of Diagnostic Pathology, Kochi Red Cross Hospital Kochi 780-0062, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Kuroda
authors.affiliation: Human Health and Medical Science, Faculty of Medicine, Kochi University Nankoku 783-8505, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Taguchi
authors.affiliation: Laboratory of Diagnostic Pathology, Kochi Medical School Hospital Nankoku 783-8505, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Matsumoto
authors.affiliation: Laboratory of Diagnostic Pathology, Kochi Medical School Hospital Nankoku 783-8505, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hiroi
authors.affiliation: Department of Urology, Kochi Medical School Nankoku 783-8505, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Nao
authors.affiliation: Department of Urology, Kochi Medical School Nankoku 783-8505, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fukata
authors.affiliation: Department of Urology, Kochi Medical School Nankoku 783-8505, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Inoue
authors.affiliation: Department of Urology, Kochi Medical School Nankoku 783-8505, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Shuin
mesh_terms: D018249:Adenoma, Oxyphilic / Q000473:pathology; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male
keywords: Renal cell carcinoma; chromophobe; eosinophilic; oncocytoma; papillary