title: The Impact of MMP-2 and Its Specific Inhibitor TIMP-2 Expression on the WHO Grade and Prognosis of Gliomas in Chinese Population: a Meta-Analysis.
abstract: So far, the prognostic value of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of matrix metalloproteinase 2 (TIMP-2) expressions in patients with gliomas has been widely reported, especially in China. But, the results were inconsistent. Thus, we conducted a meta-analysis to determine the correlation of MMP-2 and TIMP-2 expressions with the prognosis of patients with gliomas. Identical search strategies were used to search relevant literature in electronic databases updated to May 1, 2015, and odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were estimated. Funnel plots and Egger's tests were conducted for the evaluation of publication bias, and heterogeneity and sensitivity were also analyzed. Finally, a total of 25 studies involving 1572 patients were included in the meta-analysis. Coincidentally, all these studies were conducted in Chinese population. It was found that MMP-2 expression was significantly associated with high-WHO grade gliomas (n = 24, OR = 6.54, CI = 4.98-8.60; I2= 0 %, P = 0.911) and poor overall survival (OS), while it did not correlate to age (n = 2, OR = 0.78, CI = 0.35-1.74; I2= 0 %, P = 0.621) and gender (n = 2, OR = 1.15, CI = 0.51-2.62; I2= 0 %, P = 0.995). Moreover, the results of the pooled analysis indicated that there was no association between TIMP-2 expression and the WHO grade of gliomas (n = 7, OR = 1.02, 95 % CI = 0.68-1.54; I2= 71.4 %, P = 0.002), but the ratio of MMP-2 and TIMP-2 (MMP-2/TIMP-2) rose with the increase of the WHO grade of gliomas. In conclusion, there was no correlation between TIMP-2 expression and the WHO grade of gliomas, while MMP-2 expression was potently associated with high-WHO grade of gliomas.
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Avenue North Road No.1838, Guangzhou, 510515, People's Republic of China.
authors.forename: Guo-Zhong
authors.initials: GZ
authors.lastname: Yi
authors.affiliation: The Second College of Clinical Medicine, Southern Medical University, Avenue North Road No.1838, Guangzhou, 510515, People's Republic of China.
authors.forename: Wen-Yan
authors.initials: WY
authors.lastname: Feng
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Avenue North Road No.1838, Guangzhou, 510515, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Avenue North Road No.1838, Guangzhou, 510515, People's Republic of China.
authors.forename: Ya-Wei
authors.initials: YW
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Avenue North Road No.1838, Guangzhou, 510515, People's Republic of China. qisongtaosjwk@163.com.
authors.forename: Song-Tao
authors.initials: ST
authors.lastname: Qi
mesh_terms: D044466:Asian People / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis / Q000235:genetics*; D060787:Neoplasm Grading / Q000639:trends; D011159:Population Surveillance; D011379:Prognosis; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000096:biosynthesis / Q000235:genetics*; D014944:World Health Organization
chemical_list: D014408:Biomarkers, Tumor; C560823:TIMP2 protein, human; D019716:Tissue Inhibitor of Metalloproteinase-2; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2
keywords: Gliomas; MMP-2; Meta-analysis; Prognosis; TIMP-2; WHO grade