title: Introduction: Examining the many potential reasons why euploid blastocysts do not always result in viable pregnancies: part 1.
abstract: The environment of the oocyte and embryo includes the metabolic effects of aging, lifestyle issues, psychological stress, nutritional supplements/replacements, cellular energy levels, endocrine and paracrine factors, the cumulus, exogenous gonadotropins and adjunctive medications, culture media, and the in vitro fertilization laboratory's conditions and manipulations. These complex factors, which will be examined in the following series of reviews, explain in part why not all euploid blastocysts result in viable pregnancies.
authors.affiliation: Reproductive Partners La Jolla, La Jolla, California; Division of Reproductive Endocrinology and Infertility, Department of Reproductive Medicine, University of California at San Diego, San Diego, California. Electronic address: drmeldrum@gmail.com.
authors.forename: David R
authors.initials: DR
authors.lastname: Meldrum
mesh_terms: D000367:Age Factors; D000818:Animals; D001755:Blastocyst / Q000473:pathology*; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000009:adverse effects; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro / Q000009:adverse effects; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D008019:Life Style; D054315:Oocyte Retrieval / Q000009:adverse effects; D009865:Oocytes / Q000473:pathology; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects*; D012307:Risk Factors; D013312:Stress, Physiological; D013315:Stress, Psychological / Q000150:complications; D017211:Treatment Failure
keywords: CoQ10; Oocyte environment; aging; embryo culture; psychological stress