title: Prediction of urine volume soon after birth using serum cystatin C.
abstract: BACKGROUND
  Urine volume is an important clinical finding particularly during the early neonatal period. Oliguria is not a sign of impaired renal function but also a predictive factor for various complications and prognoses. It has been postulated that serum cystatin C (S-CysC) is a more sensitive biomarker for renal function than serum creatinine (S-Cr) in both adults and children. The objective of the current study was to investigate whether urine volume during 24 h after birth can be predicted using S-CysC.
  
  
  METHODS
  The subjects were 87 infants. The average gestational age was 34.7 ± 2.9 weeks and the average birth weight was 2135 ± 614 g. Blood samples were obtained from either the umbilical cord or the peripheral veins or artery of the newborn at birth. Data regarding the amount of urine volume and fluid intake during the first 24 h of life, maternal S-Cr and S-CysC levels within 48 h before delivery, and neonatal S-Cr and S-CysC levels at birth were collected from the medical records.
  
  
  RESULTS
  A significantly positive correlation was observed between maternal and neonatal S-Cr levels (r = 0.84, p < 0.0001) but not between maternal S-Cr levels and neonatal S-CysC levels (r = -0.069, p = 0.52). A significant negative correlation was seen between neonatal S-CysC levels and urine volume (r = -0.47, p < 0.0001).
  
  
  CONCLUSIONS
  The present study findings indicate that it may be possible to use S-CysC levels at birth to predict urine volume during the first 24 h of life.
authors.affiliation: Department of Obstetrics and Gynecology, Kansai Medical University, Osaka, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kasamatsu
authors.affiliation: Department of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ohashi
authors.affiliation: Department of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Tsuji
authors.affiliation: Department of Obstetrics and Gynecology, Kansai Medical University, Osaka, Japan.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Okada
authors.affiliation: Department of Obstetrics and Gynecology, Kansai Medical University, Osaka, Japan.
authors.forename: Hideharu
authors.initials: H
authors.lastname: Kanzaki
authors.affiliation: Department of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan. kanekok@hirakata.kmu.ac.jp.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Kaneko
mesh_terms: D015415:Biomarkers / Q000097:blood; D055316:Cystatin C / Q000097:blood*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D009846:Oliguria / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013997:Time Factors; D014554:Urination; D014563:Urodynamics
chemical_list: D015415:Biomarkers; D055316:Cystatin C
keywords: Creatinine; Cystatin C; Neonate; Oliguria; Urine volume