title: Macrophages and pancreatic ductal adenocarcinoma.
abstract: Monocytes and macrophages make up part of the innate immune system and provide one of the first defenses against variety of treats. Macrophages can also modulate the adaptive immune system. Efficient sensing and response to tissue environmental cues highlights the complexity and dynamic nature of macrophages and their plasticity. Macrophages may have divergent roles depending on their polarity and stimulus received. Accumulating evidence demonstrates the critical role played by macrophages in tumor initiation, development, and progression. In this review, we discuss the characteristics of tumor-associated macrophages (TAMs) and their role in pancreatic adenocarcinoma. In addition, we give an overview on recent advances related to the therapeutic implication associated with targeting TAMs in pancreas cancer.
authors.affiliation: Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: aidah@stanford.edu.
authors.forename: Aida
authors.initials: A
authors.lastname: Habtezion
authors.affiliation: Departments of Medicine and Biomedical Sciences Cedars-Sinai Medical Center, Veterans Affairs Greater Los Angeles Healthcare System & University of California at Los Angeles, Los Angeles, CA, USA.
authors.forename: Mouad
authors.initials: M
authors.lastname: Edderkaoui
authors.affiliation: Departments of Medicine and Biomedical Sciences Cedars-Sinai Medical Center, Veterans Affairs Greater Los Angeles Healthcare System & University of California at Los Angeles, Los Angeles, CA, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Pandol
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D021441:Carcinoma, Pancreatic Ductal / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction; D059016:Tumor Microenvironment
chemical_list: D000970:Antineoplastic Agents
keywords: Macrophages; Pancreas cancer; Pancreatic ductal adenocarcinoma; Tumor associated macrophages