title: The epidemiology of rotavirus disease in under-five-year-old children hospitalized with acute diarrhea in central Uganda, 2012-2013.
abstract: A cross-sectional study was undertaken during 2012-2013 to determine the prevalence, strains and factors associated with rotavirus infection among under-5-year-old children hospitalized with acute diarrhea in Uganda. Rotaviruses were detected in 37 % (263/712) of the children. The most prevalent strains were G9P[8] (27 %, 55/204) and G12P[4] (18.6 %, 38/204). Mixed infections were detected in 22.5 % (46/204) of the children. The study suggests that consumption of raw vegetables (OR = 1.45, 95 % CI = 1.03-2.03) and family ownership of dogs (OR = 1.9, 95 % CI = 1.04-3.75) increases the risk of rotavirus infection. The study findings will be used to assess the impact of RV vaccination in Uganda.
authors.affiliation: Uganda Virus Research Institute, 51-59 Nakiwogo Road, P.O. BOX 49, Entebbe, Uganda. josephinebwn@yahoo.co.uk.|Department of Paediatrics and Child Health, College of Health Sciences, Makerere University, P.O. BOX 7072, Kampala, Uganda. josephinebwn@yahoo.co.uk.
authors.forename: Josephine
authors.identifier: http://orcid.org/0000-0001-6975-7106
authors.initials: J
authors.lastname: Bwogi
authors.affiliation: Uganda Virus Research Institute, 51-59 Nakiwogo Road, P.O. BOX 49, Entebbe, Uganda.
authors.forename: Samuel
authors.initials: S
authors.lastname: Malamba
authors.affiliation: Uganda Virus Research Institute, 51-59 Nakiwogo Road, P.O. BOX 49, Entebbe, Uganda.
authors.forename: Brian
authors.initials: B
authors.lastname: Kigozi
authors.affiliation: Uganda Virus Research Institute, 51-59 Nakiwogo Road, P.O. BOX 49, Entebbe, Uganda.
authors.forename: Prossy
authors.initials: P
authors.lastname: Namuwulya
authors.affiliation: Department of Paediatrics and Child Health, College of Health Sciences, Makerere University, P.O. BOX 7072, Kampala, Uganda.
authors.forename: Phionah
authors.initials: P
authors.lastname: Tushabe
authors.affiliation: Department of Paediatrics and Child Health, College of Health Sciences, Makerere University, P.O. BOX 7072, Kampala, Uganda.
authors.forename: Sarah
authors.initials: S
authors.lastname: Kiguli
authors.affiliation: Department of Microbiology, College of Veterinary Medicine and Biosecurity, Makerere University, P.O. BOX 7072, Kampala, Uganda.
authors.forename: Denis Karuhize
authors.initials: DK
authors.lastname: Byarugaba
authors.affiliation: Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Desselberger
authors.affiliation: Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Ronald Ross Building, West Derby Street, Liverpool, L69 7BE, UK.
authors.forename: Miren
authors.initials: M
authors.lastname: Iturriza-Gomara
authors.affiliation: Department of Paediatrics and Child Health, College of Health Sciences, Makerere University, P.O. BOX 7072, Kampala, Uganda.
authors.forename: Charles
authors.initials: C
authors.lastname: Karamagi
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D012400:Rotavirus Infections / Q000453:epidemiology*; D014454:Uganda / Q000453:epidemiology
keywords: Food hygiene; Genotyping; Mixed infections; Reassortment; Rotavirus; Zoonotic transmission