title: Investigating cell culture dynamics combining high density recordings with dimensional reduction techniques.
abstract: High density multielectrode array recordings with CMOS-MEAs allow to monitor cell culture activity with unprecedent details respect to previous recording techniques. This is clarifying how network activity develops and is motivating the development of novel data analysis tools. Here, in order to advance in the exploitation of the richness of these large-scale array recordings, we introduce a principal component analysis approach that aims at improving on existing methodologies to describe neural activity events within large networks.
authors.forename: Thierry
authors.initials: T
authors.lastname: Nieus
authors.forename: Stefano
authors.initials: S
authors.lastname: Di Marco
authors.forename: Alessandro
authors.initials: A
authors.lastname: Maccione
authors.forename: Hayder
authors.initials: H
authors.lastname: Amin
authors.forename: Luca
authors.initials: L
authors.lastname: Berdondini
mesh_terms: D000200:Action Potentials; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D018929:Cell Culture Techniques / Q000295:instrumentation / Q000379:methods; D002478:Cells, Cultured; D004558:Electric Stimulation; D004566:Electrodes; D006624:Hippocampus / Q000166:cytology; D009415:Nerve Net / Q000166:cytology; D009474:Neurons / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D025341:Principal Component Analysis
chemical_list: D000316:Adrenergic alpha-Agonists; D009638:Norepinephrine