title: Hydrogels Constructed from Engineered Proteins.
abstract: Due to their various potential biomedical applications, hydrogels based on engineered proteins have attracted considerable interest. Benefitting from significant progress in recombinant DNA technology and protein engineering/design techniques, the field of protein hydrogels has made amazing progress. The latest progress of hydrogels constructed from engineered recombinant proteins are presented, mainly focused on biorecognition-driven physical hydrogels as well as chemically crosslinked hydrogels. The various bio-recognition based physical crosslinking strategies are discussed, as well as chemical crosslinking chemistries used to engineer protein hydrogels, and protein hydrogels' various biomedical applications. The future perspectives of this fast evolving field of biomaterials are also discussed.
authors.affiliation: Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 1Z1, Canada.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 1Z1, Canada.
authors.forename: Na
authors.initials: N
authors.lastname: Kong
authors.affiliation: Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 1Z1, Canada.
authors.forename: Bryce
authors.initials: B
authors.lastname: Laver
authors.affiliation: Key Lab for Supramolecular Structure and Materials, Jilin University, Changchun, Jilin Province, 130012, P. R. China.
authors.forename: Junqiu
authors.initials: J
authors.lastname: Liu
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D003432:Cross-Linking Reagents / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry; D015202:Protein Engineering
chemical_list: D000596:Amino Acids; D003432:Cross-Linking Reagents; D020100:Hydrogels; D010455:Peptides
keywords: biomedical applications; biorecognition; chemical crosslinking; hydrogels; protein engineering; protein hydrogels