title: Human herpesvirus-8-unrelated primary effusion lymphoma of the elderly not associated with an increased serum lactate dehydrogenase level: A benign sub-group of effusion lymphoma without chemotherapy.
abstract: Human herpesvirus-8-unrelated primary effusion lymphoma characterized by lymphomatous effusion without nodal lesions occasionally exhibits spontaneous remission. To elucidate the factors associated with a good prognosis, this study analyzed the clinical parameters of four patients treated in the department and 109 patients reported in case reports. The median age was 71 years and the median overall survival was 20 months. Patients possessing two independent favorable factors, an elderly status (≥ 70 years) and low serum lactate dehydrogenase (< 500 IU/L) showed a markedly higher 1-year survival than patients lacking either of the two factors in the absence of chemotherapy (94% vs 20%, p = 3 × 10(-5)), which was similarly observed in the chemotherapy group (94% vs 51%, p = 0.002). The use of rituximab was also a strong predictor of survival (89% vs 49%, p = 7 × 10(-6)). Elderly patients not exhibiting an increased lactate dehydrogenase may represent a benign sub-group of effusion lymphoma, which do not require chemotherapy to achieve remission.
authors.affiliation: a Cellular Transplantation Biology, Kanazawa University , Kanazawa , Japan ;
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Zaimoku
authors.affiliation: a Cellular Transplantation Biology, Kanazawa University , Kanazawa , Japan ;|b Department of Hematology , Ishikawa Prefectural Central Hospital , Kanazawa , Japan.
authors.forename: Wakana
authors.initials: W
authors.lastname: Takahashi
authors.affiliation: a Cellular Transplantation Biology, Kanazawa University , Kanazawa , Japan ;
authors.forename: Noriko
authors.initials: N
authors.lastname: Iwaki
authors.affiliation: a Cellular Transplantation Biology, Kanazawa University , Kanazawa , Japan ;|b Department of Hematology , Ishikawa Prefectural Central Hospital , Kanazawa , Japan.
authors.forename: Chizuru
authors.initials: C
authors.lastname: Saito
authors.affiliation: a Cellular Transplantation Biology, Kanazawa University , Kanazawa , Japan ;
authors.forename: Akiyo
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: a Cellular Transplantation Biology, Kanazawa University , Kanazawa , Japan ;
authors.forename: Go
authors.initials: G
authors.lastname: Aoki
authors.affiliation: b Department of Hematology , Ishikawa Prefectural Central Hospital , Kanazawa , Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Yamaguchi
authors.affiliation: a Cellular Transplantation Biology, Kanazawa University , Kanazawa , Japan ;
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakao
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001706:Biopsy; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D060085:Coinfection; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications* / Q000821:virology; D019288:Herpesvirus 8, Human; D006801:Humans; D016130:Immunophenotyping; D045022:Lactate Dehydrogenases / Q000097:blood*; D054685:Lymphoma, Primary Effusion / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D045022:Lactate Dehydrogenases
keywords: Lymphoma and Hodgkin disease; T-cell mediated immunity; prognostication