title: Two-micrometer thulium laser resection of the prostate-tangerine technique in benign prostatic hyperplasia patients with previously negative transrectal prostate biopsy.
abstract: The 2-μm thulium laser resection of the prostate-tangerine technique (TmLRP-TT) has been introduced as a minimally invasive treatment for benign prostatic hyperplasia (BPH). This study was undertaken to assess the clinical efficacy and safety of TmLRP-TT for the treatment of BPH patients with previously negative transrectal prostate biopsy. A prospective analysis of 51 patients with previously negative transrectal prostate biopsy who underwent surgical treatment using TmLRP-TT was performed from December 2011 to December 2013. Preoperative status, surgical details, and perioperative complications were recorded. The follow-up outcome was evaluated with subjective and objective tests at 1 and 6 months. TmLRP-TT was successfully completed in all patients. Mean prostate volume, operative duration, and catheterization time were 93.3 ± 37.9 ml, 69.5 ± 39.5 min, and 6.5 ± 1.3 days, respectively. The mean International Prostate Symptom Score, quality of life score, maximum urinary flow rate, and post-void residual urine volume changed notably at 6-month follow-up (22.5 ± 6.9 vs 6.1 ± 3.2, 4.8 ± 1.3 vs 1.1 ± 0.9, 7.3 ± 4.5 vs 18.9 ± 7.1 ml s-1 , and 148.7 ± 168.7 vs 28.4 ± 17.9 ml). Two (3.9%) patients required blood transfusion perioperatively, while 3 (5.9%) patients experienced transient hematuria postoperatively, and 2 (3.9%) patients received 3 days recatheterization due to clot retention. TmLRP-TT is a safe and effective minimally invasive technique for patients with previously negative transrectal prostate biopsy during the 6-month follow-up. This promising technology may be a feasible surgical method for previously negative transrectal prostate biopsy in the future.
authors.affiliation: Department of Urology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhuo
authors.affiliation: Department of Urology, Zhejiang Provincial People's Hospital, Xiacheng District, Hangzhou 310014, China.
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Wei
authors.affiliation: Department of Urology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Urology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Liu
authors.affiliation: Department of Urology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
authors.forename: Fu-Jun
authors.initials: FJ
authors.lastname: Zhao
authors.affiliation: Department of Urology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
authors.forename: Bang-Min
authors.initials: BM
authors.lastname: Han
authors.affiliation: Department of Urology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Sun
authors.affiliation: Department of Urology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
authors.affiliation: Department of Urology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China.
authors.forename: Shu-Jie
authors.initials: SJ
authors.lastname: Xia
mesh_terms: D000368:Aged; D062005:Biopsy, Large-Core Needle; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D009929:Organ Size; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology / Q000601:surgery; D011470:Prostatic Hyperplasia / Q000473:pathology / Q000601:surgery*; D013932:Thulium; D020728:Transurethral Resection of Prostate / Q000379:methods*
chemical_list: D013932:Thulium