title: Self-contained diffuse optical imaging system for real-time detection and localization of vascular occlusions.
abstract: Free flap surgery is a procedure where healthy tissue is transferred from a donor site to a recipient site of the body to fill a defect without maintaining the original blood supply to the flap. The anastomosis of the vascular network of the flap to the blood vessels adjacent to the recipient site has associated risks of arterial and/or venous occlusions that must be promptly detected to avoid temporary or permanent tissue damage. In this work, we present a skin-contact diffusion optical imaging (DOI) system able to continuously provide a three-dimensional representation of the flap oxygenation to promptly detect vascular occlusions potentially occurring in the flap. Multiple near-infrared LEDs and photodetectors were embedded into a self-contained optical sensor for prolonged monitoring of concentration changes of oxygenated (HbO) and deoxygenated hemoglobin (HbR) at multiple locations and depths. A time-efficient algorithm mapped measured oxygenation changes in a three-dimensional volume to allow surgeons and clinical personnel to detect and localize abnormal blood perfusion changes during or after surgery, in time for corrective intervention. The image reconstruction algorithm was validated using computerized flap models in which oxygenation was synthetically altered, whereas the optical system was preliminarily tested on a healthy forearm simulating a flap undergoing arterial and venous occlusions, proving the feasibility of implementing DOI in the form of a wearable patch for prolonged perfusion monitoring.
authors.forename: Luca
authors.initials: L
authors.lastname: Pollonini
authors.forename: Kiefer J
authors.initials: KJ
authors.lastname: Forseth
authors.forename: Clifford C
authors.initials: CC
authors.lastname: Dacso
authors.forename: Scott E
authors.initials: SE
authors.lastname: Parazynski
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Friedman
mesh_terms: D005542:Forearm; D058752:Free Tissue Flaps; D006801:Humans; D061848:Optical Imaging; D012867:Skin; D014652:Vascular Diseases