title: Two novel prenylated kaempferol derivatives from fresh bud's fur of Platanus acerifolia and their anti-proliferative activities.
abstract: Two novel prenylated kaempferol derivatives (1, 2), together with seven known metabolites were isolated from ethanol extract of fresh Platanus acerifolia bud's fur by multistep chromatographic processing. Structure of compounds 1 and 2 was confirmed by 1D, 2D NMR spectra and HR-ESI-MS. In addition, compound 1 was further analysed by X-ray crystallography. Anti-proliferative activities in vitro against human breast carcinoma (MCF-7) and human hepatocellular carcinoma (Hep-G2) cell lines for compound 1, 2 and 8 were evaluated. Compound 1 exhibited cytotoxic activity towards MCF-7 and Hep-G2 cell lines with the IC50values 38.2 and 39.5 μM, respectively. Moreover, compound 2 showed weak cytotoxic activities against the two cell lines.
authors.affiliation: a Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering , Southeast University , Nanjing , P.R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zuo
authors.affiliation: a Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering , Southeast University , Nanjing , P.R. China.|c Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering , Southeast University Cheng-Xian College , Nanjing , P.R. China.
authors.forename: Zhi-Xin
authors.initials: ZX
authors.lastname: Liao
authors.affiliation: a Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering , Southeast University , Nanjing , P.R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Xu
authors.affiliation: b Institute of Agro-Food Science and Technology , Shandong Academy of Agricultural Sciences , Jinan , P.R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
keywords: C-prenyl kaempferol; Platanaceae; Platanus acerifolia; cytotoxic