title: Highly enantioselective hydrogenation of α-oxy functionalized α,β-unsaturated acids catalyzed by a ChenPhos-Rh complex in CF3CH2OH.
abstract: Rhodium complexes coordinated by Chenphos are very effective catalysts for the enantioselective hydrogenation of α-aryloxy- and α-alkoxy-substituted α,β-unsaturated carboxylic acids under mild conditions in CF3CH2OH. The catalytic system could be successfully employed in building the core structure of a new FDA approved drug LCZ 696.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032, P. R. China. wpchen@fmmu.edu.cn syzhang@fmmu.edu.cn and Department of Chemistry & Chemical Biology, Department of Medicinal Chemistry, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA. xumu@rci.rutgers.edu.
authors.forename: Lin
authors.initials: L
authors.lastname: Yao
authors.affiliation: Department of Chemistry & Chemical Biology, Department of Medicinal Chemistry, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA. xumu@rci.rutgers.edu.
authors.forename: Jialin
authors.initials: J
authors.lastname: Wen
authors.affiliation: Department of Chemistry & Chemical Biology, Department of Medicinal Chemistry, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA. xumu@rci.rutgers.edu.
authors.forename: Shaodong
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Chemistry & Chemical Biology, Department of Medicinal Chemistry, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA. xumu@rci.rutgers.edu.
authors.forename: Renchang
authors.initials: R
authors.lastname: Tan
authors.affiliation: Department of Chemistry & Chemical Biology, Department of Medicinal Chemistry, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA. xumu@rci.rutgers.edu.
authors.forename: Noel Marie
authors.initials: NM
authors.lastname: Wood
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032, P. R. China. wpchen@fmmu.edu.cn syzhang@fmmu.edu.cn.
authors.forename: Weiping
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, 169 Changle West Road, Xi'an, 710032, P. R. China. wpchen@fmmu.edu.cn syzhang@fmmu.edu.cn.
authors.forename: Shengyong
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Chemistry & Chemical Biology, Department of Medicinal Chemistry, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA. xumu@rci.rutgers.edu.
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang