title: Rosai-Dorfman disease (RDD) in the paraglottic space: report of a case and review of literature.
abstract: Sinus histiocytosis with massive lymphadenopathy is also known as Rosai-Dorfman disease (RDD) and is characterized by painless bilateral cervical lymphadenopathy. In the present case report, a 67-year-old Chinese woman presented with a 3-month history of progressive voice hoarseness, progressive dyspnea on exertion and a foreign body sensation. MRI revealed a lesion involving the right side of the paraglottic space. The lesion was totally resected. Based on the histologic features and immunoreactivity for the S-100 protein and CD68, a diagnosis of RDD was made. We described an extremely unique case of RDD that was observed in the paraglottic space and discussed its clinical and histopathologic features, differential diagnoses and treatment options.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Luzhou Medical College Luzhou, Sichuan Province, China.
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Ma
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Luzhou Medical College Luzhou, Sichuan Province, China.
authors.forename: Zhuo-Ping
authors.initials: ZP
authors.lastname: Liang
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Luzhou Medical College Luzhou, Sichuan Province, China.
authors.forename: Sheng-En
authors.initials: SE
authors.lastname: Xu
authors.affiliation: Department of Pathology, Affiliated Hospital of Luzhou Medical College Luzhou, Sichuan Province, China.
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Yang
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Luzhou Medical College Luzhou, Sichuan Province, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Luzhou Medical College Luzhou, Sichuan Province, China.
authors.forename: Xiao-Qiang
authors.initials: XQ
authors.lastname: Sun
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Luzhou Medical College Luzhou, Sichuan Province, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Qin
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D005260:Female; D005931:Glottis / Q000473:pathology*; D015618:Histiocytosis, Sinus / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009418:S100 Proteins / Q000378:metabolism; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009418:S100 Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule
keywords: Laryngeal; Rosai-Dorfman disease; paraglottic space; sinus histiocytosis with massive lymphadenopathy