title: Behçet's disease-like syndrome secondary to microbial infection: a case report and review of the literature.
abstract: Behçet's disease (BD)-like syndrome is an extremely rare situation occurred after Mycobacterium tuberculosis infection and virus infection. We reported a 45-year-old woman who visited our hospital complaining of swollen left ankle, painful genital ulcer, redness in the left eye and skin rash on lower limbs. The patient had a history of pleural tuberculosis and had received anti-tuberculous therapy for one year. Her left cervical lymph node sample demonstrated tubercle bacilli DNA fragmentation. The diagnosis of tuberculous lymphadenitis and Behçet's disease (BD)-like syndrome were made. This patient's symptoms remitted following treatment with anti-tuberculous therapy. This case indicates that some microbial infection can trigger the onset of BD-like syndrome in genetically susceptible subjects. However, treatment strategy of BD-like syndrome secondary to infection is totally different from primary BD. The aim of this case report is to present our experience of the different clinical signs and treatment of BD-like syndrome to expedite its early diagnosis in future. Combination of clinical, radiological, immunophenotypic, pathological, and genetic data contribute to improving the rate of diagnosis.
authors.affiliation: Department of Rheumatology and Immunology, West China Hospital, Sichuan University Chengdu, China.
authors.forename: Lingshu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Rheumatology and Immunology, The First Affiliated Hospital of Sichuan Medical University Luzhou, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Rheumatology and Immunology, West China Hospital, Sichuan University Chengdu, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Department of Rheumatology and Immunology, West China Hospital, Sichuan University Chengdu, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Yan
authors.affiliation: Department of Rheumatology and Immunology, West China Hospital, Sichuan University Chengdu, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D001528:Behcet Syndrome / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D014388:Tuberculosis, Lymph Node / Q000150:complications* / Q000473:pathology
keywords: Behçet’s disease; Behçet’s disease-like syndrome; Mycobacterium tuberculosis; virus