title: Antidepressants modulate glycine action in rat hippocampus.
abstract: Antidepressants are drugs that relieve symptoms of depressive disorders. Fluoxetine, tianeptine, and milnacipran are different types of antidepressants, and they have widely been used for relieving of depression symptoms. In the present study, the effects of fluoxetine, tianeptine, and milnacipran on the glycine-induced ion current by nystatin-perforated patch clamp and on the amplitude of field potential in the hippocampal CA1 region by multichannel extracellular recording, MED64, system, were studied. In the present results, fluoxetine, tianeptine, and milnacipran reduced glycine-induced ion current in the hippocampal CA1 neurons in nystatin-perforated patch clamp method. These drugs enhanced the amplitude of the field potential in the hippocampal CA1 region in MED64 system. These results suggest that antidepressants may increase neuronal activity by enhancing field potential through inhibition on glycine-induced ion current.
authors.affiliation: Department of Urology, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, Korea.
authors.forename: Hyun-Kyung
authors.initials: HK
authors.lastname: Chang
authors.affiliation: Department of Urology, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, Korea.
authors.forename: Khae Hawn
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Anesthesiology and Pain Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Ki-Woon
authors.initials: KW
authors.lastname: Kang
authors.affiliation: Department of Anesthesiology and Pain Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Yoo-Jin
authors.initials: YJ
authors.lastname: Kang
authors.affiliation: Department of Community Sport and Recreation, College of Health Science, Jangan University, Hwasung, Korea.
authors.forename: Tae-Wook
authors.initials: TW
authors.lastname: Kim
authors.affiliation: Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Hun-Kyung
authors.initials: HK
authors.lastname: Park
authors.affiliation: Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Sung-Eun
authors.initials: SE
authors.lastname: Kim
authors.affiliation: Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Kim
keywords: Antidepressants; Field potential; Glycine-induced ion current; Hippocampus