title: Randomized placebo-controlled clinical study on enhancement of Medha (intelligence quotient) in school going children with Yahstimadhu granules.
abstract: BACKGROUND
  Optimal intelligence is a vital essentiality in day-to-day life, especially in children who have to build up their life in an apt manner. Yashtimadhu (Glycyrrhiza glabra Linn) is a time tested classical drug indicated for promotion of mental health mentioned in Ayurveda which may also help children to attain optimal intelligence.
  
  
  OBJECTIVE
  To evaluate the role of Yashtimadhu (Glycyrrhiza glabra Linn.) granules in enhancement of Medha (intelligence quotient [IQ]).
  
  
  METHODS
  The study was conducted on healthy school going children aged 14-16 years. Total 94 children were registered and divided into two groups. Yashtimadhu granules was administered in Group A and Wheat flour in the form of granules in Group B, the duration of treatment was 12 weeks with follow up of additional 12 weeks. Objective parameters included assessment of functional aspects of Buddhi (psychological faculty for reasoning and logic) along with the assessment of IQ, Quality of life parameters and general health condition.
  
  
  RESULTS
  Yashtimadhu granules showed statistically highly significant results in improving functional aspects of Buddhi, IQ, several aspects of quality of life parameters and health. The number needed to treat (NNT) with Yashtimadhu granules for children achieving an IQ score of 90 and above was 3.38, suggesting one in every 3.38 patients had achieved this target and for children achieving an IQ score of 110 and above the NNT was 6.66.
  
  
  CONCLUSIONS
  Yashtimadhu granules was safe throughout the course of study and indeed possessed a significant efficacy in improving Medha (IQ).
authors.affiliation: Department of Kaumarabhritya, Mahatma Gandhi Ayurved College, Hospital and Research Centre, Wardha, Maharashtra, India.
authors.forename: Srihari
authors.initials: S
authors.lastname: Sheshagiri
authors.affiliation: Department of Kaumarabhritya, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.
authors.forename: Kalpana S
authors.initials: KS
authors.lastname: Patel
authors.affiliation: Department of Kaumarabhritya, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.
authors.forename: S
authors.initials: S
authors.lastname: Rajagopala
keywords: Children; Medha; Yashtimadhu granules; intelligence quotient