title: Mechanisms and Functions of Vinculin Interactions with Phospholipids at Cell Adhesion Sites.
abstract: The cytoskeletal protein vinculin is a major regulator of cell adhesion and attaches to the cell surface by binding to specific phospholipids. Structural, biochemical, and biological studies provided much insight into how vinculin binds to membranes, what components it recognizes, and how lipid binding is regulated. Here we discuss the roles and mechanisms of phospholipids in regulating the structure and function of vinculin and of its muscle-specific metavinculin splice variant. A full appreciation of these processes is necessary for understanding how vinculin regulates cell motility, migration, and wound healing, and for understanding of its role in cancer and cardiovascular diseases.
authors.affiliation: From the Cell Adhesion Laboratory, Department of Cancer Biology and Department of Immunology and Microbial Sciences, The Scripps Research Institute, Jupiter, Florida 33458 and cmorrow@scripps.edu.
authors.forename: Tina
authors.initials: T
authors.lastname: Izard
authors.affiliation: the Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216.
authors.forename: David T
authors.initials: DT
authors.lastname: Brown
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002448:Cell Adhesion / Q000235:genetics; D002462:Cell Membrane / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002465:Cell Movement; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D010743:Phospholipids / Q000235:genetics / Q000378:metabolism*; D016596:Vinculin / Q000235:genetics / Q000378:metabolism*
chemical_list: D010743:Phospholipids; C488955:VCL protein, human; C103334:metavinculin; D016596:Vinculin
keywords: cell adhesion; cell junction; cytoskeleton; lipid; phosphoinositide; vinculin