title: Effectiveness of varenicline and counselling for smoking cessation in an observational cohort study in China.
abstract: OBJECTIVE
  To evaluate the effectiveness of varenicline for smoking cessation in Chinese smokers in a real world cessation clinic practice.
  
  
  METHODS
  A prospective observational study.
  
  
  METHODS
  Beijing, China.
  
  
  METHODS
  A total of 924 smokers (883 men and 41 women) who attended a smoking cessation clinic of a large general hospital were assessed with data from structured questionnaires at baseline and follow-up at 1, 3 and 6 months. Trained physician counsellors provided free individual counselling for all subjects and follow-up interviews with brief counselling. 332 subjects additionally prescribed varenicline according to their own choice were compared with those without varenicline.
  
  
  METHODS
  Primary outcomes were self-reported 7-day point prevalence abstinence rate and 3-month continuous abstinence rate at 6-month follow-up. Secondary outcomes were 7-day point prevalence abstinence rates at 1 and 3-month follow-up, and 1-month continuous abstinence rate at 3-month follow-up.
  
  
  RESULTS
  By intention-to-treat, the 7-day point prevalence abstinence rate with varenicline and counselling at 6 months was significantly higher than counselling only (37.0% vs 23.1%; OR, 1.75; 95% CI 1.46 to 2.62; p=0.001). The 3-month continuous abstinence rate at 6 months was higher with varenicline (33.1% vs 18.4%; OR, 2.04; 95% CI 1.61 to 2.99; p<0.001). Varenicline also showed better secondary outcomes.
  
  
  CONCLUSIONS
  Varenicline prescription in the smoking cessation clinic appeared to be effective with doubling of quit rates in Chinese smokers in a real world cessation clinic practice.
  
  
  BACKGROUND
  NCT01935505; Results.
authors.affiliation: Nanlou Faculty of Clinical Medicine, Department of Traditional Chinese Medicine and Acupuncture, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Department of Epidemiology, Institute of Geriatrics, Beijing key laboratory of Aging and Geriatrics, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: He
authors.affiliation: Nanlou Faculty of Clinical Medicine, Department of Traditional Chinese Medicine and Acupuncture, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zuo
authors.affiliation: Department of Epidemiology, Institute of Geriatrics, Beijing key laboratory of Aging and Geriatrics, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wu
authors.affiliation: Nanlou Faculty of Clinical Medicine, Department of Respiration, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Qing-Hui
authors.initials: QH
authors.lastname: Liu
authors.affiliation: Nanlou Faculty of Clinical Medicine, Department of Rehabilitation, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Nanlou Faculty of Clinical Medicine, Department of Respiration, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Chang-Xi
authors.initials: CX
authors.lastname: Zhou
authors.affiliation: Public Health, Epidemiology and Biostatistics, University of Birmingham, Birmingham, UK.
authors.forename: K K
authors.initials: KK
authors.lastname: Cheng
authors.affiliation: School of Nursing, School of Public Health, The University of Hong Kong, Hong Kong, China.
authors.forename: Sophia S C
authors.initials: SS
authors.lastname: Chan
authors.affiliation: Department of Community Medicine, School of Public Health and The University of Hong Kong, Hong Kong, China.
authors.forename: Tai Hing
authors.initials: TH
authors.lastname: Lam
mesh_terms: D000328:Adult; D000554:Ambulatory Care Facilities; D000068476:Beijing; D003376:Counseling; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018722:Nicotinic Agonists / Q000627:therapeutic use*; D010820:Physicians; D011446:Prospective Studies; D012907:Smoking / Q000188:drug therapy / Q000628:therapy*; D016540:Smoking Cessation / Q000379:methods*; D011795:Surveys and Questionnaires; D014029:Tobacco Use Disorder / Q000188:drug therapy / Q000628:therapy*; D016896:Treatment Outcome; D000068580:Varenicline / Q000627:therapeutic use*
chemical_list: D018722:Nicotinic Agonists; D000068580:Varenicline
keywords: EPIDEMIOLOGY; PREVENTIVE MEDICINE; PUBLIC HEALTH