title: [Recent Advances of Research on CEBPA Mutation in Acute Myeloid Leukemia].
abstract: CCAAT/enhancer binding protein alpha gene (CEBPA) is an important transcription factor in maintenance of differentiation of granulocyte series of hematopoietic system. It plays a key role in regulating cell proliferation and differentiation. CEBPA mutation easily occurs in M1 and M2 type of acute myeloid leukemia, about 5%-14% in adult acute myeloid leukemia and 7.9% in children with acute myeloid leukemia. At present, domestic CEBPA mutation research is far less than abroad. This review focuses on the structual characteristics and detection method of CEBPA, CEBPA clinical features, the effect of CEBPA mutation on the prognosis of patients and the choice of treatment.
authors.affiliation: Center of Oncology, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China.
authors.forename: Wen-Qing
authors.initials: WQ
authors.lastname: Yu
authors.affiliation: Center of Oncology, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China.
authors.forename: Jing-Nan
authors.initials: JN
authors.lastname: Sun
authors.affiliation: Center of Oncology, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China.
authors.forename: Ye-Hui
authors.initials: YH
authors.lastname: Tan
authors.affiliation: Center of Oncology, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China.
authors.forename: Jiu-Wei
authors.initials: JW
authors.lastname: Cui
authors.affiliation: Center of Oncology, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China. E-mail: jdyylw@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D022762:CCAAT-Enhancer-Binding Proteins; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D009154:Mutation; D011379:Prognosis
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; C515848:CEBPA protein, human