title: New diterpenoids from Sapium discolor.
abstract: Chemical fractionation of the ethanolic extract generated from the twigs and leaves of Sapium discolor led to the isolation and identification of four new macrocyclic diterpenoids including three members of the rare casbane family, sapidisins A-C (1-3), and an analog of the cembrane class, sapidisin D (4), a new 3,4-seco ent-kaurane diterpenoid (5), and 18 known phenolic compounds. Their structures were elucidated by comprehensive spectroscopic analyses especially 1D NMR (1)H-(1)H couplings and 2D NMR ROESY data. The discovery of 1-4 from S. discolor provides a clue for further study on the biogenetic evolution of the widely existent tigliane-type diterpenoids in the Sapium species.
authors.affiliation: a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Liu
authors.affiliation: a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.affiliation: a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
authors.forename: Jin-Hai
authors.initials: JH
authors.lastname: Yu
authors.affiliation: a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D031287:Sapium / Q000737:chemistry*
chemical_list: D045786:Diterpenes, Kaurane
keywords: Macrocyclic diterpenoid; Sapium discolor; casbane; cembrane; ent-kaurane