title: Population Pharmacokinetics of Bisoprolol in Hemodialysis Patients with Hypertension.
abstract: The aim of our study was to estimate clearance of bisoprolol and reveal the factors that could influence its pharmacokinetic (PK) variability in hypertensive patients on hemodialysis, using the population PK analysis. Parameters associated with plasma concentration of bisoprolol at steady state were analyzed in 63 patients (mean age 62.12 years, mean total weight 69.63 kg) who were hypertensive and on hemodialysis due to severe renal failure using non-linear mixed-effect modeling with ADVAN1 subroutine. The final regression model for the clearance of the drug included only creatinine clearance (CLcr) out of 12 tested covariates. The equation that describes CL of bisoprolol is the following: CL (l/h) = 0.12 + 6.33 * CLcr. These findings suggest that the routine measuring of serum creatinine level may be used to facilitate administration of bisoprolol in patients on hemodialysis.
authors.affiliation: Pharmacology Department, Research Center for Biomedicine, Medical Faculty, University of Nis, Nis, Serbia.
authors.forename: Valentina N
authors.initials: VN
authors.lastname: Nikolic
authors.forename: Slobodan M
authors.initials: SM
authors.lastname: Jankovic
authors.forename: Zorica M
authors.initials: ZM
authors.lastname: Dimitrijevic
authors.forename: Miodrag J
authors.initials: MJ
authors.lastname: Sokolovic
authors.forename: Branislav R
authors.initials: BR
authors.lastname: Andric
authors.forename: Dejan S
authors.initials: DS
authors.lastname: Petrovic
authors.forename: Tatjana
authors.initials: T
authors.lastname: Jevtovic-Stoimenov
authors.forename: Slavoljub
authors.initials: S
authors.lastname: Zivanovic
authors.forename: Jasmina R
authors.initials: JR
authors.lastname: Milovanovic
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017298:Bisoprolol / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D008954:Models, Biological; D006435:Renal Dialysis
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D000959:Antihypertensive Agents; D003404:Creatinine; D017298:Bisoprolol