title: Advances in the knowledge of breast cancer stem cells. A review.
abstract: Much effort has been made by researchers to elucidate the complex biology of breast cancer stem cells (BCSCs), a small subset of breast tumor cells that display stem cell properties, drive tumor initiation, and growth. In recent years, it has been suggested that BCSCs could be responsible for the process of metastasis and the development of drug resistance. These findings make the need to find the distinguishing blend of markers that can recognize only BCSCs of the utmost importance in order to be able to design new targeted therapies. This review will summarize BCSCs' main features as well as the cell surface markers that are currently used to identify them.
authors.affiliation: Functional Genomics Laboratory, National Institute of Genomic Medicine, Col. Arenal Tepepan, Delegación Tlalpan and National Autonomous University of Mexico, Mexico City, México.
authors.forename: Angela
authors.initials: A
authors.lastname: Schwarz-Cruz Y Celis
authors.affiliation: Functional Genomics Laboratory, National Institute of Genomic Medicine, Col. Arenal Tepepan, Delegación Tlalpan, Mexico City, México.
authors.forename: Magali
authors.initials: M
authors.lastname: Espinosa
authors.affiliation: Functional Genomics Laboratory, National Institute of Genomic Medicine, Col. Arenal Tepepan, Delegación Tlalpan, Mexico City, México.
authors.forename: Vilma
authors.initials: V
authors.lastname: Maldonado
authors.affiliation: Functional Genomics Laboratory, National Institute of Genomic Medicine, Col. Arenal Tepepan, Delegación Tlalpan, Mexico City, México. jmelendez@inmegen.gob.mx.
authors.forename: Jorge
authors.initials: J
authors.lastname: Melendez-Zajgla
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology*