title: [Analysis of clinicopathologic and survival characteristics in patients with right-or left-sided colon cancer].
abstract: OBJECTIVE
  This study aimed to clarify the clinical and histological parameters, and survival difference between right- and left-sided colon cancer.
  
  
  METHODS
  We retrospectively analyzed the medical records (2006.1-2009.12) of 1 088 consecutive colon cancer patients who received surgery at our hospital. Right- and left-sided colon cancers were compared regarding the clinical and histological parameters. The survival analysis was performed by the Kaplan-Meier method, and the log-rank test was used to determine the statistical significance of differences.
  
  
  RESULTS
  Right-sided colon cancer was associated with older age, a more advanced state, and poorly differentiated and undifferentiated adenocarcinoma (25.2% vs 13.2%), mucinous adenocarcinoma (33.5% vs 17.3%) and vascular invasion (9.9% vs 3.9%) were more commonly seen in right-sided colon cancer compared with right-sided colon cancer, and all these differences were statistically significant. Median overall survival was right, 67 months; and left, 68 months. The five-years overall survival of right- and left-sided colon cancer was I/II stage, 91.4% vs 88.6% (P = 0.819); III stage, 66.1% vs 75.4% (P = 0.010); and IV stage, 27.8% vs 38.5% (P = 0.020) respectively.
  
  
  CONCLUSIONS
  Right- and left-sided colon cancers are significantly different regarding clinical and histological parameters. Right-sided colon cancers in stage III and IV have a worse prognosis.
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital (Institute), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital (Institute), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China; Email: zhouzx01@163.com.
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital (Institute), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital (Institute), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital (Institute), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Xingmao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital (Institute), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
authors.forename: Weigen
authors.initials: W
authors.lastname: Zeng
mesh_terms: D000230:Adenocarcinoma; D003110:Colonic Neoplasms; D006801:Humans; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016019:Survival Analysis