title: In vivo visualization of the facial nerve in patients with acoustic neuroma using diffusion tensor imaging-based fiber tracking.
abstract: OBJECTIVE Preoperative determination of the facial nerve (FN) course is essential to preserving its function. Neither regular preoperative imaging examination nor intraoperative electrophysiological monitoring is able to determine the exact position of the FN. The diffusion tensor imaging-based fiber tracking (DTI-FT) technique has been widely used for the preoperative noninvasive visualization of the neural fasciculus in the white matter of brain. However, further studies are required to establish its role in the preoperative visualization of the FN in acoustic neuroma surgery. The object of this study is to evaluate the feasibility of using DTI-FT to visualize the FN. METHODS Data from 15 patients with acoustic neuromas were collected using 3-T MRI. The visualized FN course and its position relative to the tumors were determined using DTI-FT with 3D Slicer software. The preoperative visualization results of FN tracking were verified using microscopic observation and electrophysiological monitoring during microsurgery. RESULTS Preoperative visualization of the FN using DTI-FT was observed in 93.3% of the patients. However, in 92.9% of the patients, the FN visualization results were consistent with the actual surgery. CONCLUSIONS DTI-FT, in combination with intraoperative FN electrophysiological monitoring, demonstrated improved FN preservation in patients with acoustic neuroma. FN visualization mainly included the facial-vestibular nerve complex of the FN and vestibular nerve.
authors.affiliation: Department of Neurosurgery, PLA General Hospital, Beijing, China; and.
authors.forename: Fei
authors.initials: F
authors.lastname: Song
authors.affiliation: Department of Neurosurgery, PLA General Hospital, Beijing, China; and.
authors.forename: Yuanzheng
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Department of Neurosurgery, PLA General Hospital, Beijing, China; and.
authors.forename: Guochen
authors.initials: G
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, PLA General Hospital, Beijing, China; and.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, PLA General Hospital, Beijing, China; and.
authors.forename: Bainan
authors.initials: B
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Texas A&M Health Science Center College of Medicine, Bryan, Texas.
authors.forename: Jason H
authors.initials: JH
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, PLA General Hospital, Beijing, China; and.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D056324:Diffusion Tensor Imaging; D005154:Facial Nerve / Q000000981:diagnostic imaging*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D009464:Neuroma, Acoustic / Q000601:surgery*; D011300:Preoperative Care; D012189:Retrospective Studies
keywords: DTI-FT = diffusion tensor imaging–based fiber tracking; FA = fractional anisotropy; FIESTA = fast imaging employing steady-state acquisition; FIESTA-C = FIESTA with cycle phase sequences; FN = facial nerve; IAC = internal auditory canal; REZ = root exit zone; ROI = region of interest; cerebellopontine angle; diagnostic and operative techniques; diffusion tensor imaging; facial nerve; fiber tracking; neuroma