title: The value of FDG-PET/CT by using 3-dimensional stereotactic surface projection software analysis in the differential diagnosis of dementia.
abstract: OBJECTIVE
  To retrospectively reevaluate brain fluor-18-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging studies with 3-dimensional stereotactic surface projection (NEUROSTAT) software in order to detect changes in regional brain metabolism and to find out its contribution to the final diagnosis.
  
  
  METHODS
  A total of 48 cases were included in this study. According to clinical evaluation and neuropsychometric test results, there were 17 (35%) patients with probable Alzheimer disease (AD), 17 (35%) patients with probable frontotemporal dementia (FTD), and 14 (30%) patients with undefined advanced dementia. Brain FDG-PET imaging studies were interpreted visually and also using 3-dimensional stereotactic surface projection.
  
  
  RESULTS
  Clinic and PET findings were consistent in 20 patients and inconsistent in 14 patients. When consensus diagnosis was taken as the reference, the sensitivity, specificity, accuracy, and positive and negative predictive values of FDG-PET imaging were 93%, 85%, 90%, 90%, and 89% respectively, for AD diagnosis. The same values were 85%, 93%, 90%, 89%, and 90%, respectively, for FTD definition.
  
  
  CONCLUSIONS
  Using automatized programs that enable quantitative evaluation of regional brain glucose metabolism, in addition to visual evaluation, may increase diagnostic efficiency, as well as minimize interobserver and/or intercenter variability.
authors.forename: Esra
authors.initials: E
authors.lastname: Arslan
authors.forename: Özgül
authors.initials: Ö
authors.lastname: Ekmekçioğlu
authors.forename: Fatma Arzu
authors.initials: FA
authors.lastname: Görtan
authors.forename: Zeynep Funda
authors.initials: ZF
authors.lastname: Engin Akcan
authors.forename: Melih Engin
authors.initials: ME
authors.lastname: Erkan
authors.forename: Haci Murat
authors.initials: HM
authors.lastname: Emül
authors.forename: Metin
authors.initials: M
authors.lastname: Halaç
authors.forename: Tevfik Fikret
authors.initials: TF
authors.lastname: Çermik
authors.forename: Kerim
authors.initials: K
authors.lastname: Sönmezoğlu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003704:Dementia / Q000175:diagnosis* / Q000378:metabolism / Q000523:psychology; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012984:Software; D013238:Stereotaxic Techniques; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18