title: Low antioxidant status of serum bilirubin, uric acid, albumin and creatinine in patients with myasthenia gravis.
abstract: OBJECTIVE
  Oxidative stress and low antioxidant status play a major role in the pathogenesis of inflammatory and autoimmune diseases. Myasthenia gravis (MG) is an autoimmune condition targeting the neuromuscular junction, and its antioxidant status is still controversial. Our study aimed to investigate the correlation between the clinical characteristics of MG and the serum antioxidant status of bilirubin (Tbil, Dbil and Ibil), uric acid, albumin and creatinine.
  
  
  METHODS
  We measured serum antioxidant molecule levels of bilirubin (Tbil, Dbil and Ibil), uric acid, albumin and creatinine in 380 individuals, including 166 MG and 214 healthy controls.
  
  
  RESULTS
  We found that MG patients had significantly lower serum levels of bilirubin (Tbil, Dbil and Ibil), uric acid, albumin and creatinine than healthy controls, whether male or female. Moreover, it was also shown in our study that uric acid, albumin and creatinine levels in patients with MG were correlated with disease activity and classifications performed by the Myasthenia Gravis Foundation of America.
  
  
  CONCLUSIONS
  Our findings demonstrated that serum levels of bilirubin (Tbil, Dbil and Ibil), uric acid, albumin and creatinine were reduced in patients with MG. This suggested an active oxidative process in MG patients who had low antioxidant status.
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Dehao
authors.initials: D
authors.lastname: Yang
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Zhongqian
authors.initials: Z
authors.lastname: Su
authors.affiliation: b Department of Cardiology, The Heart Center , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Shengjie
authors.initials: S
authors.lastname: Wu
authors.affiliation: c Department of Neurology , Zhejiang Provincial People's Hospital , Hangzhou , China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Bi
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: d School of the First Clinical Medical Sciences , Wenzhou Medical University , Wenzhou , China , and.
authors.forename: Kangliang
authors.initials: K
authors.lastname: Lou
authors.affiliation: e School of Pharmacy, Key Laboratory of Biotechnology and Pharmaceutical Engineering , Wenzhou Medical University , Wenzhou , China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhang
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000097:blood*; D003404:Creatinine / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood* / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism*; D013945:Thymoma / Q000097:blood / Q000473:pathology; D014527:Uric Acid / Q000097:blood*
chemical_list: D017382:Reactive Oxygen Species; D012709:Serum Albumin; D014527:Uric Acid; D003404:Creatinine; D001663:Bilirubin
keywords: albumin; antioxidant; bilirubin; creatinine; myasthenia gravis; uric acid