title: The immunological effect of hyaluronan in tumor angiogenesis.
abstract: The relationship between the immune system and angiogenesis has been described in several contexts, both in physiological and pathological conditions, as pregnancy and cancer. In fact, different types of immune cells, such as myeloid, macrophages and denditric cells, are able to modulate tumor neovascularization. On the other hand, tumor microenvironment also includes extracellular matrix components like hyaluronan, which has a deregulated synthesis in different tumors. Hyaluronan is a glycosaminoglycan, normally present in the extracellular matrix of tissues in continuous remodeling (embryogenesis or wound healing processes) and acts as an important modulator of cell behavior by different mechanisms, including angiogenesis. In this review, we discuss hyaluronan as a modulator of tumor angiogenesis, focusing in intracellular signaling mediated by its receptors expressed on different immune cells. Recent observations suggest that the immune system is an important component in tumoural angiogenesis. Therefore, immune modulation could have an impact in anti-angiogenic therapy as a new therapeutic strategy, which in turn might improve effectiveness of treatment in cancer patients.
authors.affiliation: Centro de Investigaciones Básicas y Aplicadas (CIBA), CIT NOBA, Universidad Nacional del Noroeste de la Pcia. de Bs. As. Consejo Nacional de Investigaciones Científicas y Técnicas (UNNOBA-CONICET) , Junín, Pcia. Bs. As., Argentina ; Laboratory of Tumour Microenvironment, CIBA , Junín, Pcia. Bs. As., Argentina.
authors.forename: Fiorella M
authors.initials: FM
authors.lastname: Spinelli
authors.affiliation: Centro de Investigaciones Básicas y Aplicadas (CIBA), CIT NOBA, Universidad Nacional del Noroeste de la Pcia. de Bs. As. Consejo Nacional de Investigaciones Científicas y Técnicas (UNNOBA-CONICET) , Junín, Pcia. Bs. As., Argentina ; Laboratory of Tumour Microenvironment, CIBA , Junín, Pcia. Bs. As., Argentina.
authors.forename: Daiana L
authors.initials: DL
authors.lastname: Vitale
authors.affiliation: Centro de Investigaciones Básicas y Aplicadas (CIBA), CIT NOBA, Universidad Nacional del Noroeste de la Pcia. de Bs. As. Consejo Nacional de Investigaciones Científicas y Técnicas (UNNOBA-CONICET) , Junín, Pcia. Bs. As., Argentina ; Laboratory of Pituitary Physiopathology, CIBA , Junín, Provincia de Buenos Aires, Argentina.
authors.forename: Gianina
authors.initials: G
authors.lastname: Demarchi
authors.affiliation: Centro de Investigaciones Básicas y Aplicadas (CIBA), CIT NOBA, Universidad Nacional del Noroeste de la Pcia. de Bs. As. Consejo Nacional de Investigaciones Científicas y Técnicas (UNNOBA-CONICET) , Junín, Pcia. Bs. As., Argentina ; Laboratory of Pituitary Physiopathology, CIBA , Junín, Provincia de Buenos Aires, Argentina.
authors.forename: Carolina
authors.initials: C
authors.lastname: Cristina
authors.affiliation: Centro de Investigaciones Básicas y Aplicadas (CIBA), CIT NOBA, Universidad Nacional del Noroeste de la Pcia. de Bs. As. Consejo Nacional de Investigaciones Científicas y Técnicas (UNNOBA-CONICET) , Junín, Pcia. Bs. As., Argentina ; Laboratory of Tumour Microenvironment, CIBA , Junín, Pcia. Bs. As., Argentina.
authors.forename: Laura
authors.initials: L
authors.lastname: Alaniz