title: [Increased IL-1 and IL-6 expressions are negatively correlated with modified Japanese Orthopedic Association (mJOA) scores of discogenic low back pain].
abstract: OBJECTIVE
  To detect the expressions of IL-1 and IL-6 in the degenerative intervertebral discs of patients with discogenic low back pain (DLBP), record the modified Japanese Orthopedic Association (mJOA) scores and analyze the correlation between the expressions and the scores.
  
  
  METHODS
  The study chose 30 cases of DLBP aged between 45-65 years old from the same race and district and 10 control cases of vertebral fractures scheduled for surgical treatment but with no history of low back pain within one year and no disc degeneration based on imaging data. The degree of DLBP was evaluated by mJOA scores. Immunohistochemistry and Western blotting were used to observe the expressions of IL-1 and IL-6 in the discs. The relationship between the IL-1, IL-6 expressions and the mJOA scores was revealed by Pearson linear correlation analysis.
  
  
  RESULTS
  Compared with the control group, the expressions of IL-1 and IL-6 in the discs of DLBP patients increased significantly as immunohistochemistry and Western blotting indicated. The highest mJOA score of DLBP group was 16 points and the lowest was 7 points before operation. The expressions of IL-1 and IL-6 were negatively correlated with the mJOA scores of low back pain.
  
  
  CONCLUSIONS
  The expressions of IL-1 and IL-6 in the discs of DLBP patients were significantly elevated and negatively correlated with the mJOA scores of low back pain.
authors.affiliation: Department of Spine Surgery, Affiliated Hospital, Luzhou Medical College, Luzhou 646000, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Spine Surgery, Affiliated Hospital, Luzhou Medical College, Luzhou 646000, China. *Corresponding author, E-mail: kjp8@163.com.
authors.forename: Jianping
authors.initials: J
authors.lastname: Kang
authors.affiliation: Department of Spine Surgery, Affiliated Hospital, Luzhou Medical College, Luzhou 646000, China.
authors.forename: Daxiong
authors.initials: D
authors.lastname: Feng
authors.affiliation: Department of Spine Surgery, Affiliated Hospital, Luzhou Medical College, Luzhou 646000, China.
authors.forename: Song
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Spine Surgery, Affiliated Hospital, Luzhou Medical College, Luzhou 646000, China.
authors.forename: Han
authors.initials: H
authors.lastname: Yang
mesh_terms: D000368:Aged; D015153:Blotting, Western; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007375:Interleukin-1 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D007403:Intervertebral Disc / Q000378:metabolism / Q000473:pathology; D055959:Intervertebral Disc Degeneration / Q000150:complications / Q000378:metabolism*; D007564:Japan; D017116:Low Back Pain / Q000209:etiology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009985:Orthopedics / Q000379:methods; D010147:Pain Measurement / Q000379:methods
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6