title: Altered Saturated and Monounsaturated Plasma Phospholipid Fatty Acid Profiles in Adult Males with Colon Adenomas.
abstract: BACKGROUND
  Altered lipid metabolism and plasma fatty acid (FA) levels are associated with colorectal cancer. Obesity and elevated waist circumference (WC) increase the likelihood of developing precancerous colon adenomas.
  
  
  METHODS
  Venous blood was collected from 126 males, ages 48 to 65 years, who received routine colonoscopies. Plasma phospholipid (PPL) FAs were isolated, derivatized, and then analyzed using gas chromatography. ORs and 95% confidence intervals were determined using polytomous logistic regression after adjusting for confounding factors [i.e., age, smoking, WC, and body mass index (BMI)].
  
  
  RESULTS
  PPL palmitic acid (PA) was inversely correlated with the presence of colon adenomas (P = 0.01). For each unit increase in palmitoleic acid (OR, 3.75; P = 0.04) or elaidic acid (OR, 2.92; P = 0.04), an individual was more likely to have adenomas relative to no colon polyps. Higher enzyme activity estimates (EAE) of stearoyl-CoA desaturase-1 (SCD-1; P = 0.02) and elongation of very long chain fatty acids protein-6 (ELOVL-6; P = 0.03) were associated with an individual being approximately 1.5 times more likely to have an adenoma compared with no polyps.
  
  
  CONCLUSIONS
  PPL FAs and EAEs, which have previously been associated with colorectal cancer, are significantly different in those with adenomas when compared with those without polyps. PPL PA, elaidic acid, and SCD-1 and ELOVL-6 EAEs are associated with adenomas independent of BMI and WC.
  
  
  CONCLUSIONS
  PPL PA, elaidic acid, and SCD-1 and ELOVL-6 EAEs are associated with adenomas even after adjusting for obesity-related risk factors and may function as novel biomarkers of early colorectal cancer risk.
authors.affiliation: Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan.
authors.forename: C Austin
authors.initials: CA
authors.lastname: Pickens
authors.affiliation: Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan.
authors.forename: Ami
authors.initials: A
authors.lastname: Lane-Elliot
authors.affiliation: Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan.
authors.forename: Sarah S
authors.initials: SS
authors.lastname: Comstock
authors.affiliation: Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan. imigjeni@msu.edu.
authors.forename: Jenifer I
authors.initials: JI
authors.lastname: Fenton
mesh_terms: D000236:Adenoma / Q000097:blood*; D000368:Aged; D015179:Colorectal Neoplasms / Q000097:blood*; D005227:Fatty Acids / Q000009:adverse effects*; D005229:Fatty Acids, Monounsaturated / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated