title: A clustering based method for collagen proportional area extraction in liver biopsy images.
abstract: Collagen Proportional Area (CPA) extraction using digital image analysis (DIA) in liver biopsies provides an effective way to estimate the liver disease staging. CPA represents accurately fibrosis expansion in liver tissue. This paper presents an automated clustering-based method for fibrosis detection and CPA computation. Initially, a k-means based approach is employed to detect the liver tissue and eliminate the background. Next, the method decides about the adequacy of current biopsy, according to the size of liver tissue. Biopsies which contain small and segmented specimens must be repeated. Since the tissue has been detected, fibrosis areas are also found in the tissue. Finally, CPA is computed. For the evaluation of the proposed method 25 images are employed and the percentage errors of CPA are computed for each image. In the majority of the cases, small variation of CPA is computed, comparing to the expert's annotation.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Giannakeas
authors.forename: Markos G
authors.initials: MG
authors.lastname: Tsipouras
authors.forename: Alexandros T
authors.initials: AT
authors.lastname: Tzallas
authors.forename: Kalliroi
authors.initials: K
authors.lastname: Kyriakidi
authors.forename: Zoe E
authors.initials: ZE
authors.lastname: Tsianou
authors.forename: Pinelopi
authors.initials: P
authors.lastname: Manousou
authors.forename: Andrew
authors.initials: A
authors.lastname: Hall
authors.forename: Evaggelos C
authors.initials: EC
authors.lastname: Karvounis
authors.forename: Vasileios
authors.initials: V
authors.lastname: Tsianos
authors.forename: Epameinondas
authors.initials: E
authors.lastname: Tsianos
mesh_terms: D000465:Algorithms; D001706:Biopsy; D016000:Cluster Analysis; D003094:Collagen / Q000032:analysis*; D019992:Databases as Topic; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008099:Liver / Q000378:metabolism* / Q000473:pathology*
chemical_list: D003094:Collagen