title: The crystal structure of a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer in complex with the target RNA.
abstract: It has been confirmed by our previous studies that a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer displays high affinity and selectivity to the target RNA strand, promising mRNA inhibitory activity and excellent nuclease resistance. Herein, we have obtained a crystal structure that provides insights into these excellent antisense properties.
authors.affiliation: Department of Materials and Life Sciences, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, 102-8554 Tokyo, Japan. j.kondo@sophia.ac.jp.
authors.forename: Jiro
authors.initials: J
authors.lastname: Kondo
authors.affiliation: Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, 162-8601 Tokyo, Japan. htorigoe@rs.kagu.tus.ac.jp and Division of Medical Devices, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, 158-8501 Tokyo, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nomura
authors.affiliation: Department of Materials and Life Sciences, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, 102-8554 Tokyo, Japan. j.kondo@sophia.ac.jp.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kitahara
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, 565-0871 Osaka, Japan. obika@phs.osaka-u.ac.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Obika
authors.affiliation: Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, 162-8601 Tokyo, Japan. htorigoe@rs.kagu.tus.ac.jp.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Torigoe
mesh_terms: D001952:Bridged-Ring Compounds / Q000737:chemistry*; D018360:Crystallography, X-Ray / Q000379:methods*; D008958:Models, Molecular; D015394:Molecular Structure; D009711:Nucleotides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
chemical_list: C527205:2',4'-BNA(NC); D001952:Bridged-Ring Compounds; D009711:Nucleotides; D012313:RNA