title: Cinacalcet versus standard treatment for chronic kidney disease: a protocol for a systematic review and meta-analysis.
abstract: BACKGROUND
  Chronic kidney disease-mineral and bone disorders (CKD-MBD) have been associated with poor health outcomes, including diminished quality and length of life. Standard management for CKD-MBD includes phosphate-restricted diet, active vitamin D, vitamin D analogs, and phosphate binders. Persistently elevated parathyroid hormone (PTH) levels may require the addition of Cinacalcet hydrochloride (cinacalcet) which sensitizes calcium receptors on the parathyroid glands. The objective of this systematic review is to compare the effect of cinacalcet versus standard treatment in patients with CKD-MBD.
  
  
  METHODS
  Data sources will include MEDLINE, EMBASE, the Cochrane Register of Controlled Trials, and Web of Science from 1996 to June 2015. Teams of two reviewers will, independently and in duplicate, screen titles and abstracts and potentially eligible full text reports to determine eligibility, and subsequently abstract data and assess risk of bias in eligible trials. We will calculate the effect estimates (risk ratios or mean differences) and 95 % confidence intervals, as well as statistical measures of variability in results across studies using random effect models for patient-important and intermediate outcomes. We will use the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach to rate the quality of evidence about estimates of effect on an outcome-by-outcome basis. We will present our results with a GRADE summary table.
  
  
  CONCLUSIONS
  Our review will explore the effect of cinacalcet versus standard treatment in patients with CKD-MBD. The results of this systematic review will help guide management of this patient population, and identify targets for future research.
  
  
  BACKGROUND
  PROSPERO CRD42015020318 http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015020318.
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada. sekercn@mcmaster.ca.
authors.forename: Nigar
authors.initials: N
authors.lastname: Sekercioglu
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada. bussejw@mcmaster.ca.|The Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Canada. bussejw@mcmaster.ca.|Department of Anesthesia, McMaster University, Hamilton, Canada. bussejw@mcmaster.ca.
authors.forename: Jason W
authors.initials: JW
authors.lastname: Busse
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada. ramustafa@gmail.com.|Departments of Internal Medicine and Biomedical & Health Informatics, University of Missouri-Kansas City, Kansas City, USA. ramustafa@gmail.com.
authors.forename: Reem A
authors.initials: RA
authors.lastname: Mustafa
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada. guyatt@mcmaster.ca.|Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada. guyatt@mcmaster.ca.
authors.forename: Gordon H
authors.initials: GH
authors.lastname: Guyatt
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada. ThabanL@mcmaster.ca.|Department of Pediatrics and Anesthesia, McMaster University, Hamilton, Canada. ThabanL@mcmaster.ca.|Centre for Evaluation of Medicine, St Joseph's Healthcare Hamilton, Hamilton, Canada. ThabanL@mcmaster.ca.|Biostatistics Unit, Father Sean O'Sullivan Research Centre, St Joseph's Healthcare, 3rd Floor, Martha Wing, 50 Charlton Avenue East, Hamilton, Ontario, L8N 4A6, Canada. ThabanL@mcmaster.ca.|Population Health Research Institute, Hamilton Health Sciences, Hamilton, Canada. ThabanL@mcmaster.ca.
authors.forename: Lehana
authors.initials: L
authors.lastname: Thabane
mesh_terms: D057966:Calcimimetic Agents / Q000627:therapeutic use; D000069449:Cinacalcet / Q000627:therapeutic use*; D004032:Diet / Q000379:methods; D006801:Humans; D010281:Parathyroid Hormone / Q000627:therapeutic use; D028044:Phosphate-Binding Proteins / Q000627:therapeutic use; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy / Q000628:therapy*; D000078202:Systematic Reviews as Topic; D016896:Treatment Outcome; D014807:Vitamin D / Q000627:therapeutic use; D015201:Meta-Analysis as Topic
chemical_list: D057966:Calcimimetic Agents; D010281:Parathyroid Hormone; D028044:Phosphate-Binding Proteins; D014807:Vitamin D; D000069449:Cinacalcet