title: Chemotherapy-Induced Intestinal Mucosal Barrier Damage: a Cause of Falsely Elevated Serum 1,3-Beta-d-Glucan Levels?
abstract: Blood citrulline and intestinal fatty acid binding protein were determined as biomarkers for intestinal mucositis. Biomarker levels were correlated with corresponding serum 1,3-beta-D-glucan levels in 56 samples obtained from 33 cases with underlying hematological malignancies receiving induction chemotherapy. No correlation between biomarkers of intestinal mucositis and BDG levels was observed. (This study has been registered at ClinicalTrials.gov under registration no. NCT01576653.).
authors.affiliation: Section of Infectious Diseases and Tropical Medicine, Medical University of Graz, Graz, Austria Center for Biomarker Research in Medicine, Graz, Austria.
authors.forename: Juergen
authors.initials: J
authors.lastname: Prattes
authors.affiliation: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria martin.hoenigl@medunigraz.at reinhard.raggam@medunigraz.at.
authors.forename: Reinhard B
authors.initials: RB
authors.lastname: Raggam
authors.affiliation: Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences University Hospital Leuven, Leuven, Belgium.
authors.forename: Kim
authors.initials: K
authors.lastname: Vanstraelen
authors.affiliation: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
authors.forename: Jasmin
authors.initials: J
authors.lastname: Rabensteiner
authors.affiliation: Division of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria.
authors.forename: Christoph
authors.initials: C
authors.lastname: Hoegenauer
authors.affiliation: Section of Infectious Diseases and Tropical Medicine, Medical University of Graz, Graz, Austria Center for Biomarker Research in Medicine, Graz, Austria.
authors.forename: Robert
authors.initials: R
authors.lastname: Krause
authors.affiliation: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
authors.forename: Florian
authors.initials: F
authors.lastname: Prüller
authors.affiliation: Division of Hematology, Medical University of Graz, Graz, Austria.
authors.forename: Albert
authors.initials: A
authors.lastname: Wölfler
authors.affiliation: Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences University Hospital Leuven, Leuven, Belgium.
authors.forename: Isabel
authors.initials: I
authors.lastname: Spriet
authors.affiliation: Section of Infectious Diseases and Tropical Medicine, Medical University of Graz, Graz, Austria Center for Biomarker Research in Medicine, Graz, Austria Division of Infectious Diseases, Department of Medicine, University of California, San Diego, San Diego, California, USA Division of Pulmonology, Medical University of Graz, Graz, Austria martin.hoenigl@medunigraz.at reinhard.raggam@medunigraz.at.
authors.forename: Martin
authors.initials: M
authors.lastname: Hoenigl
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015415:Biomarkers; D005189:False Positive Reactions; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D052016:Mucositis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D012680:Sensitivity and Specificity; D055815:Young Adult; D047071:beta-Glucans / Q000097:blood
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D047071:beta-Glucans; C033363:beta-1,3-glucan