title: Antimicrobial acylphloroglucinols from the leaves of Rhodomyrtus tomentosa.
abstract: Phytochemical study on the leaves of Rhodomyrtus tomentosa resulted in the isolation of fourteen compounds including a new acylphloroglucinol, named tomentosone C (1), and a new flavonol glycoside, namely myricetin-3,7,3'-trimethyl ether-5'-O-β-glucopyranoside (2). Their structures were characterized by spectral data interpretation for new structures and in comparison with published data for known compounds. The antimicrobial activity evaluation revealed that 1 and the known acylphloroglucinol rhodomyrtone (3) exhibited significant antimicrobial activity with MIC 3.66 and 1.83 μg ml(-1), respectively, toward Staphylococcus aureus, responsible for the antimicrobial activity observed with the n-hexane and EtOAc-soluble fraction of the ethanol extract of R. tomentosa leaves.
authors.affiliation: a Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650 , China.|b University of Chinese Academy of Sciences , Beijing 100049 , China.
authors.forename: Hong-Xin
authors.initials: HX
authors.lastname: Liu
authors.affiliation: a Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650 , China.
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Tan
authors.affiliation: a Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650 , China.
authors.forename: Sheng-Xiang
authors.initials: SX
authors.lastname: Qiu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids; D044948:Flavonols; D006027:Glycosides / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D006586:Hexanes / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D027822:Myrtaceae / Q000737:chemistry*; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D005419:Flavonoids; D044948:Flavonols; D006027:Glycosides; D006586:Hexanes; D044004:Xanthones; C541823:rhodomyrtone; C026385:n-hexane; C040015:myricetin; D010696:Phloroglucinol
keywords: Rhodomyrtus tomentosa; antimicrobial activity; myricetin-3,7,3′-trimethyl ether 5′-O-β-glucopyranoside; tomentosone C