title: Editorial: Cancer-Associated Defects in the DNA Damage Response: Drivers for Malignant Transformation and Potential Therapeutic Targets.
authors.affiliation: Department of Medical Oncology, University Medical Center Groningen, University of Groningen Groningen, Netherlands.
authors.forename: Marcel A T M
authors.initials: MA
authors.lastname: van Vugt
authors.affiliation: Department I of Internal Medicine, University Hospital CologneGermany; Cologne Graduate School of Ageing Research, University of CologneCologne, Germany.
authors.forename: H Christian
authors.initials: HC
authors.lastname: Reinhardt
keywords: DNA damage response (DDR); DNA repair; cell cycle; checkpoint blockade; rewiring; synthetic lethality