title: [The advance of model of action in low-dose chronic benzene exposure induced hematotoxicity].
abstract: Benzene is classified as Group 1 carcinogen by IARC. It has been found that benzene induces hematotoxicity even in low dose exposure. The identification of key events during benzene induced hematotoxicty leads to adjustment of occupational exposure limits of benzene. In this review, we focus on the exposure, metabolism, target organs, key epigenetic changes, toxicty effects and end points of low-dose chronic benzene exposure induced hematotoxicity and finally discuss the perspectives on the future study of this area.
authors.affiliation: School of Pubilc Health, Sun Yat-sen University, Guang zhou 510080, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Gao
authors.affiliation: School of Pubilc Health, Sun Yat-sen University, Guang zhou 510080, China.
authors.forename: Zhengbao
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: School of Pubilc Health, Sun Yat-sen University, Guang zhou 510080, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Chen
authors.affiliation: School of Pubilc Health, Sun Yat-sen University, Guang zhou 510080, China; Email: chenwen@mail.sysu.edu.cn.
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
mesh_terms: D001554:Benzene / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D044127:Epigenesis, Genetic; D006801:Humans; D016273:Occupational Exposure
chemical_list: D002273:Carcinogens; D001554:Benzene