title: Assessment of the environmental and genetic factors influencing prevalence of metabolic syndrome in Saudi Arabia.
abstract: Metabolic syndrome (MS) is a combination of factors that increases the risk of cardiovascular atherosclerotic diseases including diabetes, obesity, dyslipidemia, and high blood pressure. Cardiovascular diseases are one of the leading causes of death in the adult Saudi population where the increase in cardiovascular-related mortality is augmented by the rise in the prevalence of MS. Metabolic syndrome is a multi-factorial disorder influenced by interactions between genetic and environmental components. This review aims to provide a comprehensive assessment of studied environmental and genetic factors explaining the prevalence of MS in the Kingdom of Saudi Arabia. Additionally, this review aims to illustrate factors related to the population genetics of Saudi Arabia, which might explain a proportion of the prevalence of MS.
authors.affiliation: Prince Sattam Chair for Epidemiology and Public Health Research, Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail. gossady@hotmail.com.
authors.forename: Ibrahim M
authors.initials: IM
authors.lastname: Gosadi
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D004032:Diet; D050171:Dyslipidemias / Q000235:genetics*; D015444:Exercise; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000235:genetics*; D020412:Multifactorial Inheritance; D009765:Obesity / Q000235:genetics*; D012307:Risk Factors; D012529:Saudi Arabia / Q000453:epidemiology