title: Efficacy and Safety of Tension-Free Vaginal Tape-Secur Mini-Sling Versus Standard Midurethral Slings for Female Stress Urinary Incontinence: A Systematic Review and Meta-Analysis.
abstract: OBJECTIVE
  To assess the efficacy and safety of tension-free vaginal tape (TVT)-Secur for stress urinary incontinence (SUI).
  
  
  METHODS
  A literature review was performed to identify all published trials of TVT-Secur. The search included the following databases: MEDLINE, Embase, and the Cochrane Controlled Trial Register.
  
  
  RESULTS
  Seventeen publications involving a total of 1,879 patients were used to compare TVT-Secur with tension-free obturator tape (TVT-O) and TVT. We found that TVT-Secur had significant reductions in operative time, visual analog score for pain, and postoperative complications compared with TVT-O. Even though TVT-Secur had a significantly lower subjective cure rate (P<0.00001), lower objective cure rate (P<0.00001), and higher intraoperative complication rate, compared with TVT-O at 1 to 3 years, there was no significant difference between TVT-Secur and TVT-O in the subjective cure rate (odds ratio [OR], 0.49; 95% confidence interval [CI], 0.22-1.08; P=0.08), objective cure rate (OR, 0.49; 95% CI, 0.22-1.09; P=0.08), or complications at 3 to 5 years. Moreover, TVT-Secur had significantly lower subjective and objective cure rates compared with TVT.
  
  
  CONCLUSIONS
  This meta-analysis indicates that TVT-Secur did not show an inferior efficacy and safety compared with TVT-O for SUI in 3 to 5 years, even though displaying a clear tread toward a lower efficacy in 1 to 3 years. Considering that the safety is similar, there are no advantages in using TVT-Secur.
authors.affiliation: Urology Department, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China ; Neurourology Research Division, China National Clinical Research Center for Neurological Disease, Beijing, China.
authors.forename: Wei
authors.identifier: 0000-0002-1338-4213
authors.initials: W
authors.lastname: Huang
authors.affiliation: Urology Department, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China ; Neurourology Research Division, China National Clinical Research Center for Neurological Disease, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Urology Department, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China ; Neurourology Research Division, China National Clinical Research Center for Neurological Disease, Beijing, China.
authors.forename: Huantao
authors.identifier: 0000-0001-9737-2553
authors.initials: H
authors.lastname: Zong
authors.affiliation: Urology Department, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China ; Neurourology Research Division, China National Clinical Research Center for Neurological Disease, Beijing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
keywords: Randomized Controlled Trial; Suburethral Slings; Urinary Incontinence, Stress