title: Childhood brucellosis: Review of 317 cases.
abstract: OBJECTIVE
  To describe the main epidemiological, clinical, and laboratory features, treatment options and outcome in children with brucellosis.
  
  
  METHODS
  Retrospectively evaluated data were obtained from 317 pediatric patients with brucellosis that were treated at the University Clinic for Infectious Diseases and Febrile Conditions in Skopje, during the period from 1989 to 2011. The medical records and follow-up protocols were used for evaluation.
  
  
  RESULTS
  Childhood brucellosis composed 317 (18.7%) of 1691 patients with brucellosis. The patients were median 9 years old, ranging from 7 months to 14 years, and 201 (63.4%) were males. Family history was present in 197 (62.1%), and direct contact with animals occurred in 140 (44.2%) of the children. The dominant manifestations were fever in 248 (78.2%), joint pain in 228 (71.9%) and hepatomegaly in 216 (68.1%). Organ affection was present in 206 (65.0%) of the patients. One hundred and six (33.4%) of the patients were treated with combination composed of two, and 211 (66.6%) with three antimicrobial agents. Relapses were registered in 21 (6.6%), and therapeutic failures in 3 (0.9%) of the children.
  
  
  CONCLUSIONS
  In endemic regions childhood brucellosis represents a significant part of human cases. Wide spectrum of clinical manifestations, frequent affection of various organ systems and possibility of relapses show that brucellosis could be a serious disease in this age group. The presence of fever, joint pain, sweating, and affection of various systems in children from endemic regions should alert pediatricians for the possibility of brucellosis.
authors.affiliation: Medical Faculty, 'Ss Cyril and Methodius' University, Skopje, Macedonia. Electronic address: milebos@yahoo.com.
authors.forename: Mile
authors.initials: M
authors.lastname: Bosilkovski
authors.affiliation: University Clinic for Infectious Diseases and Febrile Conditions, Skopje, Macedonia.
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Krteva
authors.affiliation: University Clinic for Infectious Diseases and Febrile Conditions, Skopje, Macedonia.
authors.forename: Sonja
authors.initials: S
authors.lastname: Caparoska
authors.affiliation: Medical Faculty, 'Ss Cyril and Methodius' University, Skopje, Macedonia; Institute for Clinical Pharmacology, Skopje, Macedonia.
authors.forename: Nikola
authors.initials: N
authors.lastname: Labacevski
authors.affiliation: Medical Faculty, 'Ss Cyril and Methodius' University, Skopje, Macedonia; University Clinic for Pediatric Surgery, Skopje, Macedonia.
authors.forename: Mile
authors.initials: M
authors.lastname: Petrovski
keywords: Brucellosis; Children; Clinical manifestation; Outcome; Treatment