title: Optimization of drug viscosity used in gas-powered liquid jet injectors.
abstract: This paper describes the effect of drug viscosity on the performance of gas powered liquid jet injectors. The analysis is accomplished utilizing a Computational Fluid Dynamics (CFD) model that obtains the stagnation pressure at the nozzle outlet. The technique is based on previous work used to predict gas power driven injector piston velocity with time. The results depict the variation in average and peak injector stagnation pressure for three different driven pressures; driving injections which vary from 0.2 cP to 87 cP in viscosity. Furthermore, a numerical representation of jet shape is also obtained to verify the effect of viscosity on jet geometry. These results demonstrate that increasing viscosity by 10 times that of water produces only a slight decrease in injector stagnation pressure and produces jets with greater confinement, which will display better characteristics for puncturing the skin.
authors.forename: Rocco
authors.initials: R
authors.lastname: Portaro
authors.forename: Haruka
authors.initials: H
authors.lastname: Nakayama
authors.forename: Hoi Dick
authors.initials: HD
authors.lastname: Ng
mesh_terms: D007277:Injections, Jet / Q000295:instrumentation / Q000379:methods*; D008962:Models, Theoretical; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011312:Pressure; D014783:Viscosity
chemical_list: D004364:Pharmaceutical Preparations