title: Effect of polyunsaturated phosphatidyl-choline on lipid transport system in alcoholic liver injury.
abstract: The aim of this study was to determine whether serum lipid composition and lipolytic activities in alcoholinduced liver dystrophy were modified by the co-administration of polyunsaturated phosphatidylcholine (PPC). Chronic alcohol intoxication was induced in rats by intragastric ethanol administration of 3.5 g/kg body weight per day over 56 days. Aqueous PPC suspension was given intragastrally in doses of 100 and 300 mg/kg body weight. Chronic alcohol intoxication led to the development of protein and lipid dystrophy of hepatocytes. PPC partially prevented alcoholic injury of the liver cells and had a normalizing effect on cholesterol esterification, lipolysis of lipoproteins and on the fatty acid composition of the main lipoprotein classes.
authors.affiliation: Department of Biochemistry, Vitebsk Medical Institute, Vitebsk, BelarusInstitute of Biochemistry, Byelorussian Academy of Sciences, Grodno, Belarus,Department of Clinical Pharmacology, Pomeran Medical Academy, Szczecin, Poland.
authors.forename: A A
authors.initials: AA
authors.lastname: Chirkin
authors.affiliation: Department of Biochemistry, Vitebsk Medical Institute, Vitebsk, BelarusInstitute of Biochemistry, Byelorussian Academy of Sciences, Grodno, Belarus,Department of Clinical Pharmacology, Pomeran Medical Academy, Szczecin, Poland.
authors.forename: N Y
authors.initials: NY
authors.lastname: Konevalova
authors.affiliation: Department of Biochemistry, Vitebsk Medical Institute, Vitebsk, BelarusInstitute of Biochemistry, Byelorussian Academy of Sciences, Grodno, Belarus,Department of Clinical Pharmacology, Pomeran Medical Academy, Szczecin, Poland.
authors.forename: I N
authors.initials: IN
authors.lastname: Grebennikov
authors.affiliation: Department of Biochemistry, Vitebsk Medical Institute, Vitebsk, BelarusInstitute of Biochemistry, Byelorussian Academy of Sciences, Grodno, Belarus,Department of Clinical Pharmacology, Pomeran Medical Academy, Szczecin, Poland.
authors.forename: V A
authors.initials: VA
authors.lastname: Kulikov
authors.affiliation: Department of Biochemistry, Vitebsk Medical Institute, Vitebsk, BelarusInstitute of Biochemistry, Byelorussian Academy of Sciences, Grodno, Belarus,Department of Clinical Pharmacology, Pomeran Medical Academy, Szczecin, Poland.
authors.forename: Y V
authors.initials: YV
authors.lastname: Saraev
authors.affiliation: Department of Biochemistry, Vitebsk Medical Institute, Vitebsk, BelarusInstitute of Biochemistry, Byelorussian Academy of Sciences, Grodno, Belarus,Department of Clinical Pharmacology, Pomeran Medical Academy, Szczecin, Poland.
authors.forename: V U
authors.initials: VU
authors.lastname: Buko
authors.affiliation: Department of Biochemistry, Vitebsk Medical Institute, Vitebsk, BelarusInstitute of Biochemistry, Byelorussian Academy of Sciences, Grodno, Belarus,Department of Clinical Pharmacology, Pomeran Medical Academy, Szczecin, Poland.
authors.forename: I A
authors.initials: IA
authors.lastname: Chirkina
authors.affiliation: Department of Biochemistry, Vitebsk Medical Institute, Vitebsk, BelarusInstitute of Biochemistry, Byelorussian Academy of Sciences, Grodno, Belarus,Department of Clinical Pharmacology, Pomeran Medical Academy, Szczecin, Poland.
authors.forename: E O
authors.initials: EO
authors.lastname: Danchenko
authors.affiliation: Department of Biochemistry, Vitebsk Medical Institute, Vitebsk, BelarusInstitute of Biochemistry, Byelorussian Academy of Sciences, Grodno, Belarus,Department of Clinical Pharmacology, Pomeran Medical Academy, Szczecin, Poland.
authors.forename: K J
authors.initials: KJ
authors.lastname: Gundermann