title: Impulsive mathematical modeling of ascorbic acid metabolism in healthy subjects.
abstract: In this work, we develop an impulsive mathematical model of Vitamin C (ascorbic acid) metabolism in healthy subjects for daily intake over a long period of time. The model includes the dynamics of ascorbic acid plasma concentration, the ascorbic acid absorption in the intestines and a novel approach to quantify the glomerular excretion of ascorbic acid. We investigate qualitative and quantitative dynamics. We show the existence and uniqueness of the global asymptotic stability of the periodic solution. We also perform a numerical simulation for the entire time period based on published data reporting parameters reflecting ascorbic acid metabolism at different oral doses of ascorbic acid.
authors.affiliation: Department of Mathematics, College of Sciences, King Saud University, Riyadh, Saudi Arabia. Electronic address: mbachar@ksu.edu.sa.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Bachar
authors.affiliation: Renal Research Institute, 4th Floor, 315 East 62th Street, New York, NY 10065, United States.
authors.forename: Jochen G
authors.initials: JG
authors.lastname: Raimann
authors.affiliation: Renal Research Institute, 4th Floor, 315 East 62th Street, New York, NY 10065, United States; Icahn School of Medicine at Mount Sinai, 1428 Madison Avenue, New York, NY 10029, United States.
authors.forename: Peter
authors.initials: P
authors.lastname: Kotanko
mesh_terms: D000284:Administration, Oral; D001205:Ascorbic Acid / Q000493:pharmacokinetics* / Q000494:pharmacology*; D006801:Humans; D008954:Models, Biological
chemical_list: D001205:Ascorbic Acid
keywords: Ascorbic acid deficiency; Ascorbic acid metabolism in human; Bio-availability; Fixed point theory; Global stability; Impulsive ordinary differential equation