title: Nocardia abscessus-related intracranial aneurysm of the internal carotid artery with associated brain abscess: A case report and review of the literature.
abstract: Nocardia infections primarily begin in the lungs and spread hematogenously to other sites in the body. Thus, a Nocardia brain abscess is not a completely uncommon occurrence. However, a Nocardia brain abscess complicated by a middle cerebral artery and infectious intracranial aneurysm is a very rare clinical entity. We present a case of an infectious intracranial aneurysm with an associated Nocardia brain abscess that required surgical intervention and resection. The patient was an immunocompetent 60-year-old male who presented with a chief complaint of headache and was found to have an infected intracranial aneurysm and cerebral abscess. He underwent drainage of the abscess with subsequent resection of the infected aneurysm. Cultures from both the blood vessel and brain tissue grew Nocardia abscessus. He was successfully treated with 6 weeks of ceftriaxone and high-dose trimethoprim-sulfamethoxazole. Infectious intracranial aneurysms of the brain caused by Nocardia are rare occurrences, and only a single previous case has been described in the literature. The outcomes of this condition can be catastrophic if it is not treated with a combination of surgery and intravenous antibiotics. The guidelines for the management of this infection are not well defined at this time.
authors.affiliation: Department of Medicine, Section of Infectious Diseases, Texas Tech University Health Sciences Center, Paul F. Foster School of Medicine, El Paso, TX, United States.
authors.forename: Yvette
authors.initials: Y
authors.lastname: Farran
authors.affiliation: Department of Medicine, Section of Infectious Diseases, Texas Tech University Health Sciences Center, Paul F. Foster School of Medicine, El Paso, TX, United States. Electronic address: suresh.Antony@att.net.
authors.forename: Suresh
authors.initials: S
authors.lastname: Antony
mesh_terms: D000792:Angiography; D001921:Brain / Q000000981:diagnostic imaging; D001922:Brain Abscess / Q000150:complications* / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D002532:Intracranial Aneurysm / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009615:Nocardia / Q000302:isolation & purification; D009617:Nocardia Infections / Q000139:chemically induced* / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D014057:Tomography, X-Ray Computed
keywords: Brain abscess; Intracranial aneurysm; Nocardia