title: [Signal intensity-time curve and quantitative dynamic contrast-enhanced magnetic resonance imaging in differentiating neoplasms of uterus].
abstract: OBJECTIVE
  To evaluate signal intensity-time (SI-Time) curve and quantitative dynamic contrast-enhanced 3.0T magnetic resonance imaging in diagnosis and differentiating neoplasm of uterus.
  
  
  METHODS
  A total of 42 cases of uterine neoplasm (20 were malignant and 22 were benign) were evaluated in our study. All cases received dynamic contrast-enhanced scanning on 3.0T MRI. The raw data was processed by Siemens Tissue 4D software and the SI-Time curve was obtained and analyzed. Pharmacokinetic modeling of Tofts with a modeled vascular input function was used for calculating volume parameters: volume transfer constant (Ktrans), reverse volume transfer constant (Kep), the extravascular extracellular space volume per unit volume of tissue (Ve). The correlation of these parameters at each groups were investigated. The SI-Time curve and the data of perfusion parameters between the 2 groups were compared by T test.
  
  
  RESULTS
  Among 20 malignant tumors, 12 were cervical carcinoma and 8 were endometrial cancer. Among the benign tumors, 13 were leiomyomas, 3 were endometrial polyp, 3 were endometrial hyperplasia, and 3 were adenomyosis. 59.1% cases of benign tumors belong to Type I curve and 65% cases of malignant tumors belong to Type II curve. There was significant difference in SI-Time curve between benign and malignant tumors (P=0.011). If Type I curve was used as diagnostic criteria for benign tumors, and Type II and III curve were for malignant tumors, the diagnostic sensitivity, specificity, positive predictive value, negative predictive value were 90.0%, 59.1%, 66.7%, and 86.7%, respectively. Ve was 0.477 ± 0.143 in malignant and 0.614 ± 0.146 in control group with significant difference (P=0.004). Ve was 0.477 ± 0.143 in malignant and 0.589 0.176 in benign group with significant difference (P=0.004). Ktrans was (0.178 ± 0.067) min⁻¹ in malignant and (0.263 ± 0.111) min⁻¹ in control group with significant difference (P=0.003). Ktrans was (0.182 ± 0.096) min⁻¹ in benign and (0.263 ± 0.111) min⁻¹ in control group with significant difference (P=0.011).
  
  
  CONCLUSIONS
  The type of SI-Time curve and perfusion parameters were important for differentiating benign and malignant uterine tumors in dynamic enhanced MRI. These parameters provide a supplement for conventional morphological MR diagnosis.
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Jinan University, Guangzhou 510630;Department of Radiology, Guangzhou First People's Hospital, Guangzhou 510180, China.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Jinan University, Guangzhou 510630;Department of Radiology, Guangzhou First People's Hospital, Guangzhou 510180, China.
authors.forename: Xinqing
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Radiology, Guangzhou First People's Hospital, Guangzhou 510180, China.
authors.forename: Guoshun
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Radiology, Guangzhou First People's Hospital, Guangzhou 510180, China.
authors.forename: Yunhai
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Radiology, Guangzhou First People's Hospital, Guangzhou 510180, China.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Xu
mesh_terms: D003287:Contrast Media; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D012680:Sensitivity and Specificity; D014594:Uterine Neoplasms / Q000175:diagnosis*; D014599:Uterus / Q000473:pathology*
chemical_list: D003287:Contrast Media