title: Aqueous Compatible Protocol to Both Alkyl and Aryl Thioamide Synthesis.
abstract: An efficient aqueous synthesis of thioamides through aldehydes, sodium sulfide, and N-substituted formamides has been developed. Both alkyl and aryl aldehydes are amenable to this protocol. N-Substituted formamides are essential for this transformation. Readily available inorganic salt (sodium sulfide) serves as the sulfur source in water, which makes this method much more practical and efficient. Furthermore, the late-stage modification of bioactive molecules and derivatives through this protocol has been established.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University , Shanghai 200062, P. R. China.
authors.forename: Jianpeng
authors.initials: J
authors.lastname: Wei
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University , Shanghai 200062, P. R. China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University , Shanghai 200062, P. R. China.|Beijing National Laboratory for Molecular Sciences (BNLMS) , Beijing 100190, P. R. China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Jiang