title: Articular manifestations in patients with Lyme disease.
abstract: OBJECTIVE
  To determine the percentage of Lyme patients with articular manifestations in NW Spain and to know their evolution and response to treatment.
  
  
  METHODS
  A retrospective study (2006-2013) was performed using medical histories of confirmed cases of Lyme disease showing articular manifestations. Clinical and laboratory characteristics, together with the treatment and evolution of the patients, were analysed.
  
  
  RESULTS
  Seventeen out of 108 LD confirmed patients (15.7%) showed articular manifestations. Regarding those 17 patients, 64.7%, 29.4% and 5.9% presented arthritis, arthralgia and bursitis, respectively. The knee was the most affected joint. Articular manifestations were often associated to neurological, dermatological and cardiac pathologies. Otherwise, most patients were in Stage III. The 11.8% of the cases progressed to a recurrent chronic arthritis despite the administration of an appropriate treatment.
  
  
  CONCLUSIONS
  Lyme disease patients showing articular manifestations should be included in the diagnosis of articular affections in areas of high risk of hard tick bite, in order to establish a suitable and early treatment and to avoid sequels.
authors.affiliation: Servicio de Pediatría, Hospital Universitario Lucus Agusti, Lugo, España. Electronic address: esther.vazquez.lopez@sergas.es.
authors.forename: María Esther
authors.initials: ME
authors.lastname: Vázquez-López
authors.affiliation: Unidad de Reumatología, Hospital del Bierzo, Ponferrada, León, España.
authors.forename: Carolina
authors.initials: C
authors.lastname: Díez-Morrondo
authors.affiliation: Servicio de Reumatología, Hospital Universitario Lucus Agusti, Lugo, España.
authors.forename: Amalia
authors.initials: A
authors.lastname: Sánchez-Andrade
authors.affiliation: Servicio de Neurología, Hospital Universitario Lucus Agusti, Lugo, España.
authors.forename: Robustiano
authors.initials: R
authors.lastname: Pego-Reigosa
authors.affiliation: Unidad de Epidemiología, Zoonosis y Salud Pública, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo, España.
authors.forename: Pablo
authors.initials: P
authors.lastname: Díaz
authors.affiliation: Servicio de Neuropediatría, Hospital Clínico Universitario, Santiago de Compostela, La Coruña, España.
authors.forename: Manuel
authors.initials: M
authors.lastname: Castro-Gago
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D008193:Lyme Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013030:Spain; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents
keywords: Articular manifestations; Diagnóstico diferencial; Differencial diagnosis; Enfermedad de Lyme; Lyme disease; Manifestaciones articulares; Tratamiento y evolución; Treatment and evolution