title: Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics of pig lines generated by crossing an MPS pulmonary lesion selected Landrace line and a highly immune capacity selected Large White line.
abstract: To understand the influence of crossbreeding on Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics, two crossbred lines were characterized. One crossbred line, LaWa, was generated by crossing the MPS pulmonary lesion selected Landrace line (La) and the highly immune-selected Large White line (Wa). The second crossbred line, LaWb, was generated by crossing the La line and the nonselected Large White line (Wb). The crossbred LbWb line (nonselected Landrace line × nonselected Large White line) and the La line were used as controls. The LaWa and LaWb lines had an intermediate level of MPS lung lesions between La and LbWb lines, although the difference was not statistically significant. After stimulation with sheep red blood cells (SRBCs), the LaWb and LaWa lines showed immune characteristics similar to that of the La line; the number of monocytes in peripheral blood increased, while B cells, T cells, secretion of SRBC-specific immunoglobulin G, and interleukin (IL)-13 decreased. Additionally, the number of natural killer (NK) cells and the expression of IL-4 and IL-17 were significantly higher in the LaWb and LaWa lines, respectively. These data suggested that crossbreeding of La and Wa lines resulted in the inheritance of some of the selected immune responses.
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Liushiqi
authors.initials: L
authors.lastname: Borjigin
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shimazu
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Katayama
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Haruki
authors.initials: H
authors.lastname: Kitazawa
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Sang-Gun
authors.initials: SG
authors.lastname: Roh
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Aso
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Katoh
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Uchida
authors.affiliation: Department of Food, Agriculture and Environment, Miyagi University, Sendai, Japan.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Suda
authors.affiliation: Miyagi Prefecture Animal Industry Experiment Station, Miyagi, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Sakuma
authors.affiliation: Miyagi Prefecture Animal Industry Experiment Station, Miyagi, Japan.
authors.forename: Mituru
authors.initials: M
authors.lastname: Nakajo
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000276:immunology; D006824:Hybridization, Genetic / Q000235:genetics* / Q000276:immunology*; D007074:Immunoglobulin G; D018793:Interleukin-13; D020381:Interleukin-17; D015847:Interleukin-4; D007694:Killer Cells, Natural; D007962:Leukocytes / Q000276:immunology; D045729:Pneumonia of Swine, Mycoplasmal / Q000235:genetics* / Q000276:immunology*; D012756:Sheep; D013552:Swine / Q000145:classification / Q000235:genetics* / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D018793:Interleukin-13; D020381:Interleukin-17; D015847:Interleukin-4
keywords: crossbred pig; disease resistance; immunogenic properties; mycoplasma pneumonia lesions