title: Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study.
abstract: The aim of the present retrospective analysis was to evaluate the treatment results for recurrent laryngeal cancer and to analyze the factors that may affect survival. A retrospective review was performed in 309 patients with recurrent laryngeal carcinoma, 224 of whom were treated between 1996 and 2009 at Sun Yat-Sen University Cancer Center (Guangzhou, Guangdong, China) and 85 of whom were treated between 2006 and 2013 at Zhejiang Cancer Hospital (Hangzhou, Zhejiang, China). The Kaplan-Meier method with the log-rank computation was used for the analysis of survival. The Cox proportional hazards model was applied to identify covariates that were significantly associated with overall survival. The actuarial 3-, 5- and 10-year survival rates were 68.9, 53.6 and 35.7%, respectively. Univariate analysis indicated that the following factors were associated with survival: Age, smoking index, tumor grade, primary tumor site, nodal status of the primary tumor, initial T stage, initial Union for International Cancer Control stage, initial treatment (radiotherapy or chemotherapy), disease-free interval, eligibility for surgery and extent of recurrence. Multivariate analysis of these factors indicated that the initial T stage, tumor grade, nodal status, disease-free interval and eligibility for surgery were significantly associated with survival. Overall, these results indicate that initial tumor stage T1 or T2, a high differentiation rate, no initial cervical lymph node metastasis, a long disease-free interval and a strong indication for salvage surgery are good prognostic factors for the survival of patients with recurrent laryngeal carcinoma.
authors.affiliation: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Peijing
authors.initials: P
authors.lastname: Li
authors.affiliation: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Weihan
authors.initials: W
authors.lastname: Hu
authors.affiliation: Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Radiation Oncology, Shaoxing People's Hospital, Shaoxing, Zhejiang 312000, P.R. China.
authors.forename: Jianjiang
authors.initials: J
authors.lastname: Liu
keywords: laryngeal carcinoma; predictive factor; prognosis; recurrence