title: Mycophenolate mofetil therapy for two cases of antiphospholipid antibody-associated chorea.
abstract: Chorea is associated with involuntary movement and may occur via an autoimmune mechanism. Until now, we treated immune-mediated chorea with glucocorticoids and cyclophosphamide as the efficacy of mycophenolate mofetil (MMF) therapy for this condition was unknown. Here, we report two cases of antiphospholipid antibody (aPL)-associated chorea that were cured by MMF. Measurement of aPL could help for future management of chorea patients. This report provides new insight into the beneficial effects of MMF on aPL-associated chorea.
authors.affiliation: a Department of Pediatrics , Japanese Red Cross Wakayama Medical Center , Wakayama , Japan and.
authors.forename: Koji
authors.initials: K
authors.lastname: Yokoyama
authors.affiliation: b Department of Pharmacovigilance , Tokyo Medical and Dental University , Tokyo , Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Mori
authors.affiliation: a Department of Pediatrics , Japanese Red Cross Wakayama Medical Center , Wakayama , Japan and.
authors.forename: Akira
authors.initials: A
authors.lastname: Yoshida
mesh_terms: D000293:Adolescent; D017152:Antibodies, Antiphospholipid / Q000097:blood; D002648:Child; D002819:Chorea / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D017152:Antibodies, Antiphospholipid; D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid
keywords: Antiphospholipid antibody; Chorea; Mycophenolate mofetil; Side effect