title: Therapeutic depletion of monocyte-derived cells protects from long-term axonal loss in experimental autoimmune encephalomyelitis.
abstract: Studies in multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE) suggest that peripheral monocyte-derived cells (MDCs) are instrumental for disease initiation. MDCs, however, are plastic, and may exert various functions once in the central nervous system (CNS) for prolonged periods. Furthermore, the long-term effect of MDC depletion on continuing axon loss is not known. We show that long-lasting depletion of MDCs, after onset of EAE clinical deficits, is accompanied by decreased CNS infiltration by pathogenic T lymphocytes. Although this treatment does not reverse clinical disease, it prevents worsening of neurological deficits and long-term axonal loss.
authors.affiliation: Shriners Hospital for Children, Northern California, Sacramento, CA, USA; University of California, Davis, School of Medicine, Sacramento, CA, USA.
authors.forename: Monica A
authors.initials: MA
authors.lastname: Moreno
authors.affiliation: Shriners Hospital for Children, Northern California, Sacramento, CA, USA.
authors.forename: Travis
authors.initials: T
authors.lastname: Burns
authors.affiliation: Shriners Hospital for Children, Northern California, Sacramento, CA, USA.
authors.forename: Pamela
authors.initials: P
authors.lastname: Yao
authors.affiliation: Shriners Hospital for Children, Northern California, Sacramento, CA, USA; University of California, Davis, School of Medicine, Sacramento, CA, USA.
authors.forename: Laird
authors.initials: L
authors.lastname: Miers
authors.affiliation: Shriners Hospital for Children, Northern California, Sacramento, CA, USA; University of California, Davis, School of Medicine, Sacramento, CA, USA.
authors.forename: David
authors.initials: D
authors.lastname: Pleasure
authors.affiliation: Shriners Hospital for Children, Northern California, Sacramento, CA, USA; University of California, Davis, School of Medicine, Sacramento, CA, USA. Electronic address: asoulika@ucdavis.edu.
authors.forename: Athena M
authors.initials: AM
authors.lastname: Soulika
mesh_terms: D000818:Animals; D001369:Axons / Q000276:immunology / Q000378:metabolism*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000378:metabolism* / Q000628:therapy*; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009000:Monocytes / Q000276:immunology / Q000378:metabolism*
keywords: Axonal protection; Clodronate; EAE; Macrophages; Microglia; Monocyte-derived cells