title: [Interleukin-6 From molecular mechanisms of signal transduction to physiological properties and therapeutic targeting].
abstract: Interleukin-6 (IL-6)--one of the most important pro-inflammatory cytokines that has a broad spectrum of immunoregulatory properties. Molecular mechanisms of signal transduction of IL-6 and its receptor, which were previously established, have recently been supplemented with a concept of trans-signaling. Selective inhibition of this signaling cascade would allow to modulate the pathological effects of IL-6. Methods of reverse genetics have helped to establish the physiological functions of IL-6 in normal state and in various diseases, including neoplasias. Therapeutic inhibitors of IL-6 or its receptor are already used for the treatment of several autoimmune diseases, however, systemic inhibition inevitably also neutralizes the protective functions of this cytokine. It is expected that in the future systemic therapy will be replaced by more specific and effective approaches that take into account the peculiarities of molecular signaling pathways in target cells and differences in the function of IL-6, depending on the cell source.
authors.affiliation: Engelhardt Institute of Molecular Biology Russian Academy of Sciences, Moscow, 119991 Russia;|marinadru@gmail.com.
authors.forename: M S
authors.initials: MS
authors.lastname: Drutskaya
authors.affiliation: Engelhardt Institute of Molecular Biology Russian Academy of Sciences, Moscow, 119991 Russia;|Department of Biology, Moscow State University, Moscow, 119991 Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Nosenko
authors.affiliation: Engelhardt Institute of Molecular Biology Russian Academy of Sciences, Moscow, 119991 Russia;|Department of Biology, Moscow State University, Moscow, 119991 Russia.
authors.forename: K-S N
authors.initials: KS
authors.lastname: Atretkhany
authors.affiliation: Engelhardt Institute of Molecular Biology Russian Academy of Sciences, Moscow, 119991 Russia;|Department of Biology, Moscow State University, Moscow, 119991 Russia.
authors.forename: G A
authors.initials: GA
authors.lastname: Efimov
authors.forename: S A
authors.initials: SA
authors.lastname: Nedospasov
mesh_terms: D000818:Animals; D019138:Antibodies, Blocking / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000188:drug therapy; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy; D019947:Receptors, Interleukin-6 / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D019138:Antibodies, Blocking; D015850:Interleukin-6; D019947:Receptors, Interleukin-6
keywords: IL-6; IL-6R; anti-cytokine therapy; chronic inflammation; gp130; interleukin 6; proinflammatory cytokines; trans-signaling