title: Electrocatalytic Generation of Amidyl Radicals for Olefin Hydroamidation: Use of Solvent Effects to Enable Anilide Oxidation.
abstract: Oxidative generation of synthetically important amidyl radicals from N-H amides is an appealing and yet challenging task. Previous methods require a stoichiometric amount of a strong oxidant and/or a costly noble-metal catalyst. We report herein the first electrocatalytic method that employs ferrocene (Fc), a cheap organometallic reagent, as the redox catalyst to produce amidyl radicals from N-aryl amides. Based on this radical-generating method, an efficient intramolecular olefin hydroamidation reaction has been developed.
authors.affiliation: Collaborative Innovation Center of Chemistry for Energy Material, Key Laboratory of Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen, 361005, P. R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Collaborative Innovation Center of Chemistry for Energy Material, Key Laboratory of Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen, 361005, P. R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xiong
authors.affiliation: Collaborative Innovation Center of Chemistry for Energy Material, Key Laboratory of Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen, 361005, P. R. China.
authors.forename: Zhong-Yi
authors.initials: ZY
authors.lastname: Mao
authors.affiliation: Collaborative Innovation Center of Chemistry for Energy Material, Key Laboratory of Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen, 361005, P. R. China.
authors.forename: Yong-Heng
authors.initials: YH
authors.lastname: Wang
authors.affiliation: Collaborative Innovation Center of Chemistry for Energy Material, Key Laboratory of Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen, 361005, P. R. China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Yan
authors.affiliation: Collaborative Innovation Center of Chemistry for Energy Material, Key Laboratory of Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen, 361005, P. R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
authors.affiliation: Collaborative Innovation Center of Chemistry for Energy Material, Key Laboratory of Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen, 361005, P. R. China. haichao.xu@xmu.edu.cn.
authors.forename: Hai-Chao
authors.identifier: http://orcid.org/0000-0002-3008-5143
authors.initials: HC
authors.lastname: Xu
keywords: amidyl radicals; electrochemistry; ferrocene; hydroamidation; redox catalysts