title: The fusion rate of demineralized bone matrix compared with autogenous iliac bone graft for long multi-segment posterolateral spinal fusion.
abstract: BACKGROUND
  Although autogenous iliac bone graft (AIBG) remains the gold standard for spine fusion, harvesting morbidity has prompted the search for alternatives especially for multi-segment fusion. This study aimed to evaluate the efficacy of using demineralized bone matrix (DBM) as a substitute of AIBG for long instrumented posterolateral fusion (≧ three-level fusion).
  
  
  METHODS
  A total of 47 consecutive patients underwent laminectomy decompression, and multi-level instrumented posterolateral fusions were reviewed. Group 1 comprised 26 patients having DBM with autologous laminectomy bone (ALB). Group 2 consisted of 21 patients having AIBG with ALB. The fusion success evaluation was based on findings using the 12-month anteroposterior and dynamic plain radiographs.
  
  
  RESULTS
  Gender, age, and the number of fusion levels were similar for both groups. 21 of 26 (80.8%) patients in group 1 and 18 of 21 (85.7%) patients in group 2 were observed to achieve solid bony fusion. There was no statistical difference in the fusion success (p = 0.72). Blood loss was significantly more in group 2 (p = 0.02). The duration of the hospital stays and operative times being longer for group 2, but the difference was not significant.
  
  
  CONCLUSIONS
  DBM combined with ALB and osteoconductive materials is as effective as an autologous iliac bone graft with respect to long multi-segment posterolateral fusion success. DBM can be used as an effective bone graft substitute and may decrease morbidities associated with iliac bone graft harvest.
authors.affiliation: Department of Orthopaedic Surgery, Chang Gung Memorial Hospital in Keelung, School of Medicine, Chang Gung University, Taoyuan, Taiwan. fts111@adm.cgmh.org.tw.
authors.forename: Tsai-Sheng
authors.initials: TS
authors.lastname: Fu
authors.affiliation: Department of Orthopaedic Surgery, Chang Gung Memorial Hospital in Keelung, School of Medicine, Chang Gung University, Taoyuan, Taiwan. icj0326@adm.cgmh.org.tw.
authors.forename: I-Chun
authors.initials: IC
authors.lastname: Wang
authors.affiliation: Department of Orthopaedic Surgery, Chang Gung Memorial Hospital in Linkou, School of Medicine, Chang Gung University, Taoyuan, Taiwan. mengling@adm.cgmh.org.tw.
authors.forename: Meng-Ling
authors.initials: ML
authors.lastname: Lu
authors.affiliation: Department of Orthopaedic Surgery, Chang Gung Memorial Hospital in Linkou, School of Medicine, Chang Gung University, Taoyuan, Taiwan. mkhsieh@adm.cgmh.org.tw.
authors.forename: Ming-Kai
authors.initials: MK
authors.lastname: Hsieh
authors.affiliation: Department of Orthopaedic Surgery, Chang Gung Memorial Hospital in Linkou, School of Medicine, Chang Gung University, Taoyuan, Taiwan. lhchen2132@adm.cgmh.org.tw.
authors.forename: Lih-Huei
authors.initials: LH
authors.lastname: Chen
authors.affiliation: Department of Orthopaedic Surgery, Chang Gung Memorial Hospital in Linkou, School of Medicine, Chang Gung University, Taoyuan, Taiwan. chenwenj@adm.cgmh.org.tw.
authors.forename: Wen-Jer
authors.initials: WJ
authors.lastname: Chen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials / Q000008:administration & dosage; D018775:Bone Demineralization Technique / Q000379:methods*; D001857:Bone Matrix / Q000000981:diagnostic imaging / Q000637:transplantation*; D016025:Bone Transplantation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007085:Ilium / Q000000981:diagnostic imaging / Q000637:transplantation*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D013123:Spinal Fusion / Q000379:methods*; D014182:Transplantation, Autologous / Q000379:methods
chemical_list: D001672:Biocompatible Materials