title: Association of Body Mass Index With Tuberculosis Mortality: A Population-Based Follow-Up Study.
abstract: Evidence regarding the association between body mass index (BMI) and mortality in TB patients is limited and inconsistent. We investigated the effect of BMI on TB-specific and non-TB-specific mortality in TB patients. All adult Taiwanese with TB in Taipei, Taiwan, during 2011 to 2012 were included in this retrospective cohort study. Multinomial logistic regression was used to evaluate associations of BMI with cause of death in TB patients. Of the 1608 eligible patients, 83.6% (1345) were successfully treated, 3.3% (53) died of TB-specific causes, and 13.1% (210) died of non-TB-specific causes. Mean age was 64.6 years, and 67.5% of patients were male. After controlling for potential confounders, underweight was significantly associated with higher risks of all-cause mortality (adjusted odds ratio [AOR], 1.66; 95% confidence interval [CI], 1.21-2.30), TB-specific mortality (AOR, 2.14; 95% CI, 1.18-3.89), and non-TB-specific mortality (AOR, 1.58; 95% CI, 1.11-2.25) during TB treatment, while overweight was not. When gender differences on the association of BMI with mortality were considered, underweight only significantly increased risks of TB-specific (AOR, 2.37; 95% CI, 1.19-4.72) and non-TB-specific mortality (AOR, 1.58; 95% CI, 1.05-2.37) during treatment in male patients, but not female subjects.T he present findings indicate that underweight was associated with higher risks of TB-specific and non-TB-specific mortality during TB treatment, particularly in male patients.
authors.affiliation: From the Section of Infectious Diseases, Taipei City Hospital, Taipei City Government (YY); School of Medicine, National Yang-Ming University (YY); Center for Prevention and Treatment of Occupational Injury and Diseases, Taipei Veterans General Hospital (PC); Division of Clinical Toxicology and Occupational Medicine, Department of Medicine, Taipei Veterans General Hospital (PC); Department of Disease Control and Prevention, Taipei City Hospital, Taipei City Government (MY, PC, MY); Department of Education and Research, Taipei City Hospital (SL); Department of Chest Medicine, Taipei City Hospital, Taipei City Government (BH); Community Medicine Research Center and Institute of Public Health, National Yang-Ming University (PC); and Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan (CD).
authors.forename: Yung-Feng
authors.initials: YF
authors.lastname: Yen
authors.forename: Pei-Hung
authors.initials: PH
authors.lastname: Chuang
authors.forename: Muh-Yong
authors.initials: MY
authors.lastname: Yen
authors.forename: Shu-Yi
authors.initials: SY
authors.lastname: Lin
authors.forename: Peing
authors.initials: P
authors.lastname: Chuang
authors.forename: Mei-Jen
authors.initials: MJ
authors.lastname: Yuan
authors.forename: Bo-Lung
authors.initials: BL
authors.lastname: Ho
authors.forename: Pesus
authors.initials: P
authors.lastname: Chou
authors.forename: Chung-Yeh
authors.initials: CY
authors.lastname: Deng
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use; D015992:Body Mass Index; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D050177:Overweight / Q000453:epidemiology; D012189:Retrospective Studies; D012737:Sex Factors; D012959:Socioeconomic Factors; D013624:Taiwan; D013851:Thinness / Q000453:epidemiology*; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents