title: Cerebrospinal fluid viral escape and acute encephalitis in a patient on boosted protease inhibitor monotherapy.
abstract: Although currently available data suffice to support the use of protease inhibitor monotherapy in selected patients, there is concern about the antiviral activity of this regimen in the long term and in viral sanctuaries, such as the central nervous system. We report a case of encephalitis related to viral escape while receiving darunavir/ritonavir monotherapy in a carefully selected patient for participation in a clinical trial.
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, London, UK. JuanManuel.Tiraboschi@gstt.nhs.uk.
authors.forename: Juan
authors.initials: J
authors.lastname: Tiraboschi
authors.forename: Lisa
authors.initials: L
authors.lastname: Hamzah
authors.forename: Ata
authors.initials: A
authors.lastname: Siddiqui
authors.forename: Ranjababu
authors.initials: R
authors.lastname: Kulasegaram
authors.forename: Frank
authors.initials: F
authors.lastname: Post
authors.forename: Julie
authors.initials: J
authors.lastname: Fox
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D000069454:Darunavir / Q000009:adverse effects; D018792:Encephalitis, Viral / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging / Q000209:etiology*; D015658:HIV Infections / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D015497:HIV-1; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D019438:Ritonavir / Q000009:adverse effects; D017211:Treatment Failure; D019562:Viral Load
chemical_list: D017320:HIV Protease Inhibitors; D019438:Ritonavir; D000069454:Darunavir