title: The association between CD209 gene polymorphisms and pulmonary tuberculosis susceptibility: a meta-analysis.
abstract: OBJECTIVE
  Three common polymorphisms in CD209 gene (-336A/G, -871A/G and -139G/A) have been reportedly associated with pulmonary tuberculosis risk. However, the findings from different studies were inconsistent. Therefore, we conducted a comprehensive meta-analysis to determine the association between CD209 gene polymorphisms and pulmonary tuberculosis susceptibility.
  
  
  METHODS
  The PubMed, SCI and Elsevier were searched up to April 18, 2015 for studies on the association of CD209 gene polymorphisms and pulmonary tuberculosis. Pooled odds ratio (ORs) and 95% confidence intervals (95% CIs) were calculated in a fixed-effects or random-effects model.
  
  
  RESULTS
  Twelve case-control studies with 3114 cases and 3088 controls were included. For -871A/G mutation, significant decreased pulmonary tuberculosis risk was observed in allele model (G vs. A: P = 0.009; OR = 0.70, 95% CI = 0.54-0.92), heterozygous model (AG vs. AA: P = 0.009; OR = 0.59, 95% CI = 0.40 to 0.88) and dominant model (AG+GG vs. AA: p =0.01; OR = 0.61, 95% CI = 0.42 to 0.89). For -336A/G polymorphism, no associations were found in all genetic models. In the subgroup analysis by ethnicity, statistical association was observed for Asians in GG vs. AA (P = 0.04; OR = 2.31, 95% CI = 1.05-5.09). No significant association was identified between -139G/A variation and pulmonary tuberculosis risk.
  
  
  CONCLUSIONS
  This meta-analysis provides evidences that CD209 gene -871A/G is associated with decreased susceptibility to pulmonary tuberculosis in overall population; -336A/G polymorphism is associated with increased susceptibility of pulmonary tuberculosis in Asians. However, the -139G/A polymorphism is not associated with susceptibility to pulmonary tuberculosis.
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, China ; Key Laboratory of Respiratory Diseases, National Health and Family Planning Commission of The People's Republic of China China ; National Clinical Research Center for Respiratory Diseases China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Yi
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, China ; Key Laboratory of Respiratory Diseases, National Health and Family Planning Commission of The People's Republic of China China ; National Clinical Research Center for Respiratory Diseases China.
authors.forename: Kan
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, China ; Key Laboratory of Respiratory Diseases, National Health and Family Planning Commission of The People's Republic of China China ; National Clinical Research Center for Respiratory Diseases China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Mo
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, China ; Key Laboratory of Respiratory Diseases, National Health and Family Planning Commission of The People's Republic of China China ; National Clinical Research Center for Respiratory Diseases China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Zhen
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, China ; Key Laboratory of Respiratory Diseases, National Health and Family Planning Commission of The People's Republic of China China ; National Clinical Research Center for Respiratory Diseases China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhao
mesh_terms: D044466:Asian People / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011956:Receptors, Cell Surface / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics*; D044465:White People / Q000235:genetics; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
keywords: CD209; Meta-analysis; polymorphism; pulmonary tuberculosis