title: Palisading and Verocay body-prominent dermatofibrosarcoma protuberans: A case report.
abstract: Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous sarcoma with a tendency for local recurrence, which commonly presents as a slowly growing flesh-colored skin lesion without epidermal invasion but with intracutaneous and subcutaneous spread. Pathologically, the tumor generally presents with an infiltrating dermal mass containing closely packed fibroblasts arranged in a storiform pattern. Several uncommon growth patterns have been described, including sclerosing, atrophic, myxoid, pigmented, giant cell-rich, granular cell, herringbone pattern and palisading/Verocay body-prominent forms. To our knowledge, only five cases of DFSP with nuclear palisading/Verocay body formation have been reported in the literature, and no t(17:22) translocation study has been done on these cases. In this report we describe such a case with negative t(17:22) translocation.
authors.affiliation: Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, 6th Floor Founders Building, Philadelphia, PA 19104, USA. Electronic address: weishuanzeng@hotmail.com.
authors.forename: Shuanzeng
authors.initials: S
authors.lastname: Wei
authors.affiliation: Dianon Pathology, 1 Forest Parkway, Shelton, CT 06484, USA. Electronic address: dumasa@labcorp.com.
authors.forename: Alain
authors.initials: A
authors.lastname: Dumas
authors.affiliation: Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, 6th Floor Founders Building, Philadelphia, PA 19104, USA. Electronic address: pjz@mail.med.upenn.edu.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Zhang
authors.affiliation: Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, 6th Floor Founders Building, Philadelphia, PA 19104, USA. Electronic address: kumarasen.cooper@uphs.upenn.edu.
authors.forename: Kumarasen
authors.initials: K
authors.lastname: Cooper
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001706:Biopsy; D018223:Dermatofibrosarcoma / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018365:Neoplasm, Residual; D012086:Reoperation; D012878:Skin Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor
keywords: Dermatofibrosarcoma protuberans; Palisading; Verocay body; t(17:22) translocation