title: Modeling leukocyte trafficking at the human blood-nerve barrier in vitro and in vivo geared towards targeted molecular therapies for peripheral neuroinflammation.
abstract: Peripheral neuroinflammation is characterized by hematogenous mononuclear leukocyte infiltration into peripheral nerves. Despite significant clinical knowledge, advancements in molecular biology and progress in developing specific drugs for inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis, there are currently no specific therapies that modulate pathogenic peripheral nerve inflammation. Modeling leukocyte trafficking at the blood-nerve barrier using a reliable human in vitro model and potential intravital microscopy techniques in representative animal models guided by human observational data should facilitate the targeted modulation of the complex inflammatory cascade needed to develop safe and efficacious therapeutics for immune-mediated neuropathies and chronic neuropathic pain.
authors.affiliation: Department of Neurology, Neuromuscular Immunopathology Research Laboratory, Division of Neuromuscular Disease, The University of Alabama at Birmingham, 1825 University Boulevard, Room 1131, Birmingham, AL, 35294-0017, USA. kelseymgreathouse@gmail.com.
authors.forename: Kelsey M
authors.initials: KM
authors.lastname: Greathouse
authors.affiliation: Department of Neurology, Neuromuscular Immunopathology Research Laboratory, Division of Neuromuscular Disease, The University of Alabama at Birmingham, 1825 University Boulevard, Room 1131, Birmingham, AL, 35294-0017, USA. stephenpalladino@uabmc.edu.
authors.forename: Steven P
authors.initials: SP
authors.lastname: Palladino
authors.affiliation: Department of Neurology, Neuromuscular Immunopathology Research Laboratory, Division of Neuromuscular Disease, The University of Alabama at Birmingham, 1825 University Boulevard, Room 1131, Birmingham, AL, 35294-0017, USA. chaolingdong@uabmc.edu.
authors.forename: Chaoling
authors.initials: C
authors.lastname: Dong
authors.affiliation: Department of Neurology, Neuromuscular Immunopathology Research Laboratory, Division of Neuromuscular Disease, The University of Alabama at Birmingham, 1825 University Boulevard, Room 1131, Birmingham, AL, 35294-0017, USA. erichelton@uabmc.edu.
authors.forename: Eric S
authors.initials: ES
authors.lastname: Helton
authors.affiliation: Department of Neurology, Neuromuscular Immunopathology Research Laboratory, Division of Neuromuscular Disease, The University of Alabama at Birmingham, 1825 University Boulevard, Room 1131, Birmingham, AL, 35294-0017, USA. eeubogu@uabmc.edu.
authors.forename: Eroboghene E
authors.initials: EE
authors.lastname: Ubogu
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000503:physiopathology*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D009443:Neuritis / Q000235:genetics / Q000628:therapy*; D017933:Peripheral Nervous System / Q000378:metabolism / Q000473:pathology*