title: Assessment of PET/CT in multifocal myeloid sarcomas with loss of TET2: a case report and literature review.
abstract: Myeloid sarcoma is a rare solid tumor consisting of leukemic myeloblasts and/or myeloid precursors occurring outside the blood or bone marrow. The unique site with myeloid sarcoma has been reported, the multiple sites of myeloid sarcoma have rarely been cited in the medical literature. Here we report that the unusual clinical presentation and management of myeloid sarcoma in multiple sites with PET-CT, highlighting the utility of PET-CT was useful in detecting and monitoring myeloid sarcoma. We also found that loss of TET2 and gain of 5 hmC in the case of myeloid sarcoma, indicating the mechanism for myeloid sarcoma is totally different with other hematopoietic malignancies.
authors.affiliation: Department of Pathology, Xiangya Hospital, Central South University Changsha 410078, Hunan, China ; Department of Pathology, School of Basic Medicine, Central South University Changsha 410078, Hunan, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Department of Pathology, Xiangya Hospital, Central South University Changsha 410078, Hunan, China ; Cancer Research Institute, Central South University Changsha 410078, Hunan, China ; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education Changsha 410078, Hunan, China ; Key Laboratory of Carcinogenesis, National Health and Family Planning Commission Changsha 410078, Hunan, China ; Center for Molecular Imaging, Central South University Changsha 410078, Hunan, China.
authors.forename: Yongguang
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Department of Pathology, Xiangya Hospital, Central South University Changsha 410078, Hunan, China ; Department of Pathology, School of Basic Medicine, Central South University Changsha 410078, Hunan, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Fu
authors.affiliation: Cancer Research Institute, Central South University Changsha 410078, Hunan, China ; Department of Pathophysiology, Changzhi Medical College Changzhi 046000, Shanxi, China.
authors.forename: Jiantao
authors.initials: J
authors.lastname: Jia
authors.affiliation: Center for Medicine Research, Xiangya Hospital, Central South University Changsha 410008, Hunan, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Pathology, Xiangya Hospital, Central South University Changsha 410078, Hunan, China ; Department of Pathology, School of Basic Medicine, Central South University Changsha 410078, Hunan, China.
authors.forename: Desheng
authors.initials: D
authors.lastname: Xiao
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D004268:DNA-Binding Proteins / Q000032:analysis*; D049308:Dioxygenases; D005260:Female; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D023981:Sarcoma, Myeloid / Q000473:pathology*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D049308:Dioxygenases; C541081:TET2 protein, human
keywords: 5 hmC; CD117; MPO; Myeloid sarcoma; PET-CT; TET2