title: Comparison of the effect of rocuronium dosing based on corrected or lean body weight on rapid sequence induction and neuromuscular blockade duration in obese female patients.
abstract: OBJECTIVE
  To compare onset time, duration of action, and tracheal intubation conditions in obese patients when the intubation dose of rocuronium was based on corrected body weight (CBW) versus lean body weight (LBW) for rapid sequence induction.
  
  
  METHODS
  This prospective study was carried out at Numune Education and Research Hospital, Ankara, Turkey between August 2013 and May 2014. Forty female obese patients scheduled for laparoscopic surgery under general anesthesia were randomized into 2 groups. Group CBW (n=20) received 1.2 mg/kg rocuronium based on CBW, and group LBW (n=20) received 1.2 mg/kg rocuronium based on LBW. Endotracheal intubation was performed 60 seconds after injection of muscle relaxant, and intubating conditions were evaluated. Neuromuscular transmission was monitored using acceleromyography of the adductor pollicis. Onset time, defined as time to depression of the twitch tension to 95% of its control value, and duration of action, defined as time to achieve one response to train-of-four stimulation (T1) were recorded.
  
  
  RESULTS
  No significant differences were observed between the groups in intubation conditions or onset time (50-60 seconds median, 30-30 interquartile range [IQR]). Duration of action was significantly longer in the CBW group (60 minutes median, 12 IQR) than the LBW group (35 minutes median, 16 IQR; p less than 0.01).
  
  
  CONCLUSIONS
  In obese patients, dosing of 1.2 mg/kg rocuronium based on LBW provides excellent or good tracheal intubating conditions within 60 seconds after administration and does not lead to prolonged duration of action.
authors.affiliation: Department of Anesthesiology and Reanimation, Tatvan State Hospital, Bitlis, Turkey. E-mail. drsakizciuyar@gmail.com.
authors.forename: Bahar
authors.initials: B
authors.lastname: Sakızcı-Uyar
authors.forename: Seref
authors.initials: S
authors.lastname: Çelik
authors.forename: Aysun
authors.initials: A
authors.lastname: Postacı
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Bayraktar
authors.forename: Bayazit
authors.initials: B
authors.lastname: Dikmen
authors.forename: Işıl
authors.initials: I
authors.lastname: Özkoçak-Turan
authors.forename: Ozlem
authors.initials: O
authors.lastname: Saçan
mesh_terms: D000328:Adult; D000732:Androstanols / Q000008:administration & dosage*; D000768:Anesthesia, General / Q000379:methods; D001835:Body Weight; D054796:Drug Dosage Calculations; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods*; D010535:Laparoscopy; D008875:Middle Aged; D009213:Myography; D019148:Neuromuscular Blockade / Q000379:methods*; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage*; D009765:Obesity; D000077123:Rocuronium; D013997:Time Factors; D055815:Young Adult
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D000077123:Rocuronium