title: Is there a relationship between tea intake and maternal whole blood heavy metal concentrations?
abstract: The aim of this analysis was to examine the association between tea intake during pregnancy and maternal and infant metal exposures. Data from the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a pan-Canadian pregnancy cohort, were used. All participants with a gestational age of ⩾20 weeks (n=1954) with available biomarkers were included. Geometric means (GMs) for lead, arsenic, mercury, cadmium and manganese in maternal (first and third trimesters) and cord blood, as well as speciated arsenic in maternal urine in the first trimester, were calculated for participants who drank regular, green or herbal tea and for those who did not. Differences between groups were examined using chi-square tests. Adjusted least squares geometric means (LSGMs) were estimated by tea intake, controlling for factors such as country of birth, coffee intake and maternal smoking. Concentrations of all metals were above the limits of detection in most participants in the first trimester: lead (GM): 0.62 μg/dl), mercury (GM: 2.99 nmol/l); cadmium (GM 1.93 nmol/l), arsenic (GM 9.75 nmol/l) and manganese (GM 160.1 nmol/l). Adjusted LSGMs for lead in the first trimester were higher for tea drinkers than for those who were non-tea drinkers (LSGM 0.65 μg/dl, 95%CI: 0.62, 0.69 and 0.61 μg/dl, 95%CI: 0.59, 0.62), and there was evidence of a dose-response relationship for green and herbal tea. Those who consumed herbal tea in the third trimester had significantly higher third trimester maternal and cord blood lead concentrations than non-herbal tea drinkers. This study provides evidence of an association between blood lead concentrations and green or herbal tea consumption. However, the GM blood lead concentrations of the highest tea consumers were still less than 1 μg/dl and within the normal range of blood lead concentrations in the Canadian population.
authors.affiliation: Department of Obstetrics and Gynecology, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: Cynthia K
authors.initials: CK
authors.lastname: Colapinto
authors.affiliation: Population Studies Division, Environmental Health Science and Research Bureau, Environmental and Radiation Health Sciences Directorate, Healthy Environments and Consumer Safety Branch, Health Canada, Environmental Health Center, Ottawa, Ontario, Canada.
authors.forename: Tye E
authors.initials: TE
authors.lastname: Arbuckle
authors.affiliation: Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Lise
authors.initials: L
authors.lastname: Dubois
authors.affiliation: Department of Obstetrics and Gynecology, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: William
authors.initials: W
authors.lastname: Fraser
mesh_terms: D000328:Adult; D001151:Arsenic; D002101:Cacodylic Acid / Q000652:urine; D002104:Cadmium; D002170:Canada; D015331:Cohort Studies; D004785:Environmental Pollutants / Q000097:blood / Q000652:urine; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007854:Lead; D008345:Manganese; D018811:Maternal Exposure / Q000009:adverse effects*; D008431:Maternal-Fetal Exchange; D008628:Mercury; D019216:Metals, Heavy / Q000097:blood* / Q000652:urine*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011263:Pregnancy Trimester, Third; D012044:Regression Analysis; D011795:Surveys and Questionnaires; D013662:Tea / Q000737:chemistry*; D000069459:Teas, Herbal / Q000032:analysis*; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D019216:Metals, Heavy; D013662:Tea; D000069459:Teas, Herbal; D002104:Cadmium; D007854:Lead; D008345:Manganese; D002101:Cacodylic Acid; D008628:Mercury; D001151:Arsenic