title: Simulation and evaluation of tablet-coating burst based on finite element method.
abstract: The objective of this study was to simulate and evaluate the burst behavior of coated tablets. Three-dimensional finite element models of tablet-coating were established using software ANSYS. Swelling pressure of cores was measured by a self-made device and applied at the internal surface of the models. Mechanical properties of the polymer film were determined using a texture analyzer and applied as material properties of the models. The resulted finite element models were validated by experimental data. The validated models were used to assess the factors those influenced burst behavior and predict the coating burst behavior. The simulation results of coating burst and failure location were strongly matched with the experimental data. It was found that internal swelling pressure, inside corner radius and corner thickness were three main factors controlling the stress distribution and burst behavior. Based on the linear relationship between the internal pressure and the maximum principle stress on coating, burst pressure of coatings was calculated and used to predict the burst behavior. This study demonstrated that burst behavior of coated tablets could be simulated and evaluated by finite element method.
authors.affiliation: a School of Pharmacy , Zhejiang University of Technology , Hangzhou , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: a School of Pharmacy , Zhejiang University of Technology , Hangzhou , China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: a School of Pharmacy , Zhejiang University of Technology , Hangzhou , China.
authors.forename: Kong-Song
authors.initials: KS
authors.lastname: Miao
authors.affiliation: a School of Pharmacy , Zhejiang University of Technology , Hangzhou , China.
authors.forename: Wei-Guang
authors.initials: WG
authors.lastname: Shan
authors.affiliation: a School of Pharmacy , Zhejiang University of Technology , Hangzhou , China.
authors.forename: Lan
authors.initials: L
authors.lastname: Tang
authors.affiliation: a School of Pharmacy , Zhejiang University of Technology , Hangzhou , China.
authors.forename: Hai-Ning
authors.initials: HN
authors.lastname: Yu
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003198:Computer Simulation; D005079:Excipients / Q000737:chemistry; D020342:Finite Element Analysis; D008962:Models, Theoretical; D011108:Polymers / Q000737:chemistry; D011312:Pressure; D013314:Stress, Mechanical; D013607:Tablets / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D005079:Excipients; D011108:Polymers; D013607:Tablets
keywords: Finite element simulation; geometrical model; swelling pressure; tablet-coating burst behavior