title: Mathematical analysis of dermal absorption rate of heavy metals.
abstract: Presently 90 - 95% of children in the US wear disposable diapers before completing their toilet training at average age of 30 months. The diaper absorbs urine and liquid component from feces contaminated with excreted toxicants. In this initial study, we posit that the long contact between the diaper and the skin leads to increased dermal reabsorption of excreted body toxicants, mainly heavy metals, which are statistically associated with autism and neurodevelopmental disorder. We developed a mathematical model to analyse the increase of the level of toxicants due to dermal reabsorption after excretion. This simple kinetic model gives us the average reabsorbtion factor in the range of 1.6 to 5. The limitation of this work is that only mathematical model has been considered and it has not been verified experimentally.
authors.forename: Izmail
authors.initials: I
authors.lastname: Batkin
authors.forename: Miodrag
authors.initials: M
authors.lastname: Bolic
mesh_terms: D006801:Humans; D016496:Incontinence Pads; D019216:Metals, Heavy; D012867:Skin; D012869:Skin Absorption
chemical_list: D019216:Metals, Heavy