title: Candida nivariensis as a New Emergent Agent of Vulvovaginal Candidiasis: Description of Cases and Review of Published Studies.
abstract: Candida nivariensis is a new emergent agent related to human infections in the vaginal tract and other localizations, but the phenotypic characteristics are very similar to Candida glabrata and can be misidentified and underdiagnosed. We described four cases of vulvovaginitis identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and confirmed the results with PCR amplification and sequencing of the entire ITS genomic region (ITS1, ITS2 and 5.8 rRNA). We reinforce the need for new diagnostic tools for the correct identification of yeast infections.
authors.affiliation: Clinical Microbiology Lab, Puerta del Mar University Hospital, University of Cádiz, Cádiz, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Aznar-Marin
authors.affiliation: Clinical Microbiology Lab, Puerta del Mar University Hospital, University of Cádiz, Cádiz, Spain.
authors.forename: Fátima
authors.initials: F
authors.lastname: Galan-Sanchez
authors.affiliation: Clinical Microbiology Lab, Puerta del Mar University Hospital, University of Cádiz, Cádiz, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Marin-Casanova
authors.affiliation: Clinical Microbiology Lab, Puerta del Mar University Hospital, University of Cádiz, Cádiz, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: García-Martos
authors.affiliation: Clinical Microbiology Lab, Puerta del Mar University Hospital, University of Cádiz, Cádiz, Spain. manuel.rodrigueziglesias@uca.es.
authors.forename: Manuel
authors.initials: M
authors.lastname: Rodríguez-Iglesias
mesh_terms: D000328:Adult; D002175:Candida / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D002181:Candidiasis, Vulvovaginal / Q000175:diagnosis* / Q000382:microbiology*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D005260:Female; D006801:Humans; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D055815:Young Adult
chemical_list: D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer
keywords: Candida nivariensis; Emerging yeasts; MALDI-TOF; Vaginitis