title: rs3806268 of NLRP3 gene polymorphism is associated with the development of primary gout.
abstract: The aim of the present study was to investigate the association between seven functional SNPs in NALP3 gene and the susceptibility to primary gout. A total of 247 patients with primary gout and 247 controls were selected in this study. Genotyping of NALP3 rs4612666, rs3806268, rs12239046, rs10754558, rs7512998, rs12137901 and rs12565738 was performed using the Sequenom MassARRAY platform. Comparison analysis showed that primary gout patients were more likely to have a higher body mass index, DBP, SBP, TG, urea nitrogen and uric acid (P < 0.05). According to logistic regression analysis, individuals carrying with the GG genotype of rs3806268 were associated with increased risk of primary gout when compared with the AA genotype (OR=1.83, 95% CI=1.03-3.26). However, no significant associations were identified for the remaining SNPs. In conclusion, we found a significant association between rs3806268 in NLRP3 gene and the risk of primary gout in a Chinese population. Further clinical and genetic studies are required to investigate the mechanisms underlying the association between NALP3 polymorphisms and the development of primary gout.
authors.affiliation: Clinical Laboratory, Love & Health Hospital of Huangshi Huangshi 435000, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Deng
authors.affiliation: Clinical Laboratory, Love & Health Hospital of Huangshi Huangshi 435000, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Lin
authors.affiliation: Clinical Laboratory, Love & Health Hospital of Huangshi Huangshi 435000, China.
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Clinical Laboratory, Love & Health Hospital of Huangshi Huangshi 435000, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Clinical Laboratory, Love & Health Hospital of Huangshi Huangshi 435000, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Yin
authors.affiliation: Clinical Laboratory, Love & Health Hospital of Huangshi Huangshi 435000, China.
authors.forename: Chunhong
authors.initials: C
authors.lastname: Yao
authors.affiliation: Clinical Laboratory, Love & Health Hospital of Huangshi Huangshi 435000, China.
authors.forename: Tangbing
authors.initials: T
authors.lastname: Liu
authors.affiliation: Clinical Laboratory, Love & Health Hospital of Huangshi Huangshi 435000, China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Lv
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006073:Gout / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014527:Uric Acid / Q000097:blood
chemical_list: D015415:Biomarkers; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; D014527:Uric Acid
keywords: NLRP3; polymorphism; primary gout