title: Two new compounds, deacetylisowortmins A and B, isolated from an endophytic Fungus, Talaromyces wortmannii LGT-4.
abstract: Two new compounds, deacetylisowortmins A (1) and B (2), were isolated from Talaromyces wortmannii LGT-4. Their structures were established by 1D and 2D NMR spectra, as well as comparison of the experimental and calculated electronic circular dichroism spectra. Monoamine oxidase and acetylcholinesterase inhibitory activities of 1 and 2 were also evaluated.
authors.affiliation: a School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , P.R. China.
authors.forename: Guang-Chao
authors.initials: GC
authors.lastname: Fu
authors.affiliation: a School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , P.R. China.|b The Provincial Education Key Laboratory of Screening, Evaluation and Advanced Processing of Traditional Chinese Medicine and Tibetan Medicine, School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , P.R. China.
authors.forename: Zhong-Duo
authors.initials: ZD
authors.lastname: Yang
authors.affiliation: c Department of Chemistry , Lanzhou University , Lanzhou , P.R. China.
authors.forename: Shuang-Yan
authors.initials: SY
authors.lastname: Zhou
authors.affiliation: d Insititute of Plant Protection , Gansu Academy of Agricultural Sciences , Lanzhou , P.R. China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Yu
authors.affiliation: a School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , P.R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Zhang
authors.affiliation: c Department of Chemistry , Lanzhou University , Lanzhou , P.R. China.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Yao
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D002942:Circular Dichroism; D060026:Endophytes / Q000737:chemistry; D005285:Fermentation; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D032901:Talaromyces / Q000737:chemistry*
chemical_list: D002800:Cholinesterase Inhibitors; D006576:Heterocyclic Compounds, 4 or More Rings; D008996:Monoamine Oxidase Inhibitors; C000617371:deacetylisowortmin A; C000617372:deacetylisowortmin B
keywords: Endophytic fungus; Talaromyces wortmannii; deacetylisowortmins; enzyme inhibition; structure elucidation