title: [Survival analysis of the AIDS patients under 14 years of age and receiving antiretroviral treatment in Henan province from 2003 to 2014].
abstract: OBJECTIVE
  To analyze the survival status and influencing factors of the AIDS patients under 14 years of age and receiving antiretroviral treatment in Henan Province.
  
  
  METHODS
  Database of children AIDS patients receiving ART were download from China information system for disease preventioin and control-AIDS, AIDS cases from January, 2003 to June, 2014 were selected to be analyzed. Demographic characteristics baseline laboratory inclusion criteria: F First time receive national free ART during study; aged 14 years or below; and with relatively complete baseline information and follow-up information. 1 037 cases were selected. Patient information about survival status, death, demographic characteristics, and baseline laboratory test results were analyzed. The accumulated survival rate of AIDS patients was calculated by life table method and the influencing factors were analyzed by COX proportional hazard model.
  
  
  RESULTS
  A total of 1 037 AIDS children-cases ((9.52 ± 3.56) years old) which included 628 boys and 409 girls were recruited in the study, 939 cases survived 1 to 9 years from starting ART treatment and 98 cases died. Accumulated survival rate of AIDS children receiving ART from 1 year to 9 years were 96.11%, 94.17%, 92.74%, 91.28%, 90.54%, 89.47%, 88.52%, 88.52%, 86.84%, respectively. Results of multivariate analysis showed baseline count of CD4⁺ T lymphocyte (HR = 0.51, 95% CI: 0.36-0.72), duration from confirmation to the initial ART time (HR = 0.85, 95% CI: 0.75-0.97) and hemoglobin level (HR = 2.26, 95% CI: 1.09-4.70) were influence factors for survival time of AIDS children patients receiving ART.
  
  
  CONCLUSIONS
  Survival rate of AIDS children aged 14 years or below and receiving ART in Henan Province was relatively high. Timely surveillance of CD4⁺ T and the hemoglobin level of the AIDS patients so as to timely launch HARRT could extend survival time of AIDS patients.
authors.affiliation: Center for Disease Prevention and Control of Henan Province, Zhengzhou 450016, China.
authors.forename: Dingyong
authors.initials: D
authors.lastname: Sun
authors.affiliation: Center for Disease Prevention and Control of Henan Province, Zhengzhou 450016, China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Yang
authors.affiliation: Center for Disease Prevention and Control of Henan Province, Zhengzhou 450016, China.
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Center for Disease Prevention and Control of Henan Province, Zhengzhou 450016, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Center for Disease Prevention and Control of Henan Province, Zhengzhou 450016, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Center for Disease Prevention and Control of Henan Province, Zhengzhou 450016, China.
authors.forename: Panying
authors.initials: P
authors.lastname: Fan
authors.affiliation: Center for Disease Prevention and Control of Henan Province, Zhengzhou 450016, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: Center for Disease Prevention and Control of Henan Province, Zhengzhou 450016, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Center for Disease Prevention and Control of Henan Province, Zhengzhou 450016, China; Email: wangzhe@hncdc.com.cn.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000401:mortality*; D000293:Adolescent; D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D016016:Proportional Hazards Models; D016019:Survival Analysis; D015996:Survival Rate