title: [Correlation between Expression of Signal Transducer and Activator of Transcription 3 and Pituitary Adenoma Subtypes].
abstract: OBJECTIVE
  To investigate the correlation between signal transducer and activator of transcription 3 (STAT3) expression and pituitary adenoma subtypes.
  
  
  METHODS
  The STAT3 expression profiles in different pituitary adenomas from 74 patients were determined using quantificational real-time polymerase chain reaction,Western blot,and immunohistochemistry.
  
  
  RESULTS
  Expression of STAT3 was observed in all pituitary adenoma subtypes. The STAT3 expression level was highest in growth hormone adenoma when compared with other tumors including prolactin,follicle-stimulating hormone/luteinizing hormone-secreting adenoma,and adrenocorticotrophic hormone-secreting adenoma. The follicle-stimulating hormone/luteinizing hormone adenomas exhibited the lowest STAT3 expression levels.
  
  
  CONCLUSIONS
  STAT3 is differentially expressed in pituitary adenoma subtypes, suggesting the cell-specific features of STAT3 regulation,although further investigations are still warranted to clarify the underlying mechanisms.
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Yong-hui
authors.initials: YH
authors.lastname: Jiao
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Xiao-hai
authors.initials: XH
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Cong-xin
authors.initials: CX
authors.lastname: Dai
authors.affiliation: Department of Neurosurgery,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China.
authors.forename: Feng
authors.initials: F
authors.lastname: Cai
authors.affiliation: Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Ren-zhi
authors.initials: RZ
authors.lastname: Wang
mesh_terms: D000236:Adenoma; D005640:Follicle Stimulating Hormone; D019382:Human Growth Hormone; D006801:Humans; D007150:Immunohistochemistry; D010911:Pituitary Neoplasms; D060888:Real-Time Polymerase Chain Reaction; D050796:STAT3 Transcription Factor; D015398:Signal Transduction
chemical_list: D050796:STAT3 Transcription Factor; D019382:Human Growth Hormone; D005640:Follicle Stimulating Hormone