title: Cross-sectional pilot study about the liver enzymes profile in type 2 diabetic patients from an Algerian west region: Wilaya of Mostaganem.
abstract: OBJECTIVE
  The magnitude of abnormal liver enzymes profile in type 2 diabetic patients is unknown in Algerian west region even though it counts among liver diseases considered as an important cause of death in type 2 diabetes. The main objective is to assess the prevalence of elevated liver enzymes levels among patients with type 2 diabetes from Algerian west region and to determine associated risk factors.
  
  
  METHODS
  A descriptive cross sectional study was performed on 180 type 2 diabetic patients in whom anthropometric and biochemical parameters were determined.
  
  
  RESULTS
  Twenty-five patients had abnormal elevated alanine transaminase (ALT) (13.9%) with the gender-wise prevalence being 15.9% (n=17) in women and 10.9% (n=8) in men. The prevalence of abnormal elevated aspartate transaminase (AST), gamma glutamyl transferase and alkaline phosphatase level was respectively 10% (n=18), 6.1% (n=11) and 8.9% (16). High waist circumference (OR: 5, CI: 1.04-24.04) and high blood pressure (OR: 4.86, CI: 0.94-25.12) were only associated with elevated AST. Fasting glucose >1.4g/l were associated both with elevated ALT (OR: 3.03, CI: 0.86-10.67) and AST (OR: 5.7, CI: 1.09-29.8).
  
  
  CONCLUSIONS
  A relatively high prevalence of elevated liver enzymes was found in diabetic patients from west Algeria, especially in female patients.
authors.affiliation: Laboratoire de technologie alimentaire et nutrition, Université Abd ElHamid Ibn Badis, Mostaganem, Algeria. Electronic address: lbelkacemi@hotmail.fr.
authors.forename: Louiza
authors.initials: L
authors.lastname: Belkacemi
authors.affiliation: Laboratoire de structure, Élaboration et application des matériaux moléculaires, Université Abd ElHamid Ibn Badis, Mostaganem, Algeria.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Belalia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood*; D000462:Algeria / Q000453:epidemiology; D001219:Aspartate Aminotransferases / Q000097:blood*; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000097:blood / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008107:Liver Diseases / Q000097:blood / Q000453:epidemiology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D015995:Prevalence; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Algerian west region; Alkaline phosphatase; Gamma glutamyl transferase; Transaminases; Type 2 diabetes