title: Gender-specific association between metabolic syndrome and decreased glomerular filtration rate in elderly population.
abstract: OBJECTIVE
  Few studies have investigated the association between metabolic syndrome (MS) and chronic kidney disease in the elderly. Accordingly, the aim of this study was to examine the sex-specific association between MS and decreased glomerular filtration rate (GFR) in a Chinese elderly population.
  
  
  METHODS
  We performed cross-sectional analyses of older (age ≥60 years) males (n = 19,015) and females (n = 23,310) classified as 0, 1, 2, 3, 4, and 5 component(s) or MS group based on the presenting MS component(s). Sex-specific relationship of decreased GFR with MS component(s) was analyzed by logistic regression models.
  
  
  RESULTS
  Compared with participants with 0 component of MS, males with 1, 2, 3, 4, and 5 component(s) had 1.40-, 1.79-, 2.41-, 3.29-, and 4.09-fold risks for decreased GFR; females with 1, 2, 3, 4, and 5 component(s) had 1.65-, 1.71-, 1.88-, 2.32-, and 1.96-fold risks for decreased GFR, respectively. The multivariate-adjusted odds ratios for decreased GFR in males and females with MS compared with those without MS were 1.79 and 1.25, respectively. For participants without hypertension and diabetes, the association of MS with decreased GFR was still significant.
  
  
  CONCLUSIONS
  In this study of 42,325 Chinese participants aged ≥60 years, MS was significantly associated with decreased GFR, and the association was more profound for males than females.
authors.affiliation: Department of Cardiology, The Third Xiang-Ya Hospital, Central South University, Changsha, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wen
authors.affiliation: Center of Clinical Pharmacology, The Third Xiang-Ya Hospital, Central South University, 138 Tong-Zi-Po Road, 410013, Changsha, Hunan, People's Republic of China.
authors.forename: Chen-Xian
authors.initials: CX
authors.lastname: Guo
authors.affiliation: School of Community Health Sciences, University of Nevada, Reno, NV, USA.
authors.forename: Ming-Gen
authors.initials: MG
authors.lastname: Lu
authors.affiliation: Center of Clinical Pharmacology, The Third Xiang-Ya Hospital, Central South University, 138 Tong-Zi-Po Road, 410013, Changsha, Hunan, People's Republic of China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Lu
authors.affiliation: School of Pharmacy, Central South University, Changsha, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Cardiology, The Third Xiang-Ya Hospital, Central South University, Changsha, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Liu
authors.affiliation: Center of Clinical Pharmacology, The Third Xiang-Ya Hospital, Central South University, 138 Tong-Zi-Po Road, 410013, Changsha, Hunan, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Center of Clinical Pharmacology, The Third Xiang-Ya Hospital, Central South University, 138 Tong-Zi-Po Road, 410013, Changsha, Hunan, People's Republic of China.
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Huang
authors.affiliation: The Pediatric Heart Center, Beijing Anzhen Hospital, Capital Medical University, 2 An-Zhen Road, 100029, Beijing, People's Republic of China. ping.zhang@hotmail.com.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Zhang
authors.affiliation: Center of Clinical Pharmacology, The Third Xiang-Ya Hospital, Central South University, 138 Tong-Zi-Po Road, 410013, Changsha, Hunan, People's Republic of China. yhxy3yy@126.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Yuan
mesh_terms: D000367:Age Factors; D000368:Aged; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D012307:Risk Factors; D012737:Sex Factors
keywords: Chronic kidney disease; Decreased glomerular filtration rate; Elderly; Metabolic syndrome