title: Pyrrolizidine alkaloids from Solenanthus lanatus DC. with acetylcholinesterase inhibitory activity.
abstract: The whole plant ethanolic extract of Solenanthus lanatus was used for the isolation of acetylcholinesterase inhibitors. A new pyrrolizidine alkaloid, 7-O-angeloylechinatine N-oxide, 1, was isolated together with three known compounds of the same class (3'-O-acetylheliosupine N-oxide, 2, heliosupine N-oxide, 3, and heliosupine, 4), by bioassay-guided approach. Their structures were elucidated by spectroscopic methods. All the isolated compounds showed inhibition activity against the AChE, with IC500.53-0.60 mM.
authors.affiliation: a Laboratory of Biochemistry and Natural Products, Department of Biology, Faculty of Natural Sciences and Life , University of Oran 1 Ahmed Benbella , Oran , Algeria.|b Department of Biology, Faculty of Natural Sciences and Life , University of Mostaganem Abdelhamid Ibn Badis , Mostaganem , Algeria.
authors.forename: Houari
authors.initials: H
authors.lastname: Benamar
authors.affiliation: c Department of Environmental Biology , University "Sapienza" , Rome , Italy.
authors.forename: Lamberto
authors.initials: L
authors.lastname: Tomassini
authors.affiliation: c Department of Environmental Biology , University "Sapienza" , Rome , Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Venditti
authors.affiliation: a Laboratory of Biochemistry and Natural Products, Department of Biology, Faculty of Natural Sciences and Life , University of Oran 1 Ahmed Benbella , Oran , Algeria.|d Institute of Science and Technology , Department of Natural Sciences and Life , Ctr Univ Naama , Naama , Algeria.
authors.forename: Abderrazak
authors.initials: A
authors.lastname: Marouf
authors.affiliation: a Laboratory of Biochemistry and Natural Products, Department of Biology, Faculty of Natural Sciences and Life , University of Oran 1 Ahmed Benbella , Oran , Algeria.|e Laboratory of Research in Arid Areas, Faculty of Biological Sciences , University of Science and Technology Houari Boumediene , Algiers , Algeria.
authors.forename: Malika
authors.initials: M
authors.lastname: Bennaceur
authors.affiliation: c Department of Environmental Biology , University "Sapienza" , Rome , Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Nicoletti
keywords: 7-O-angeloylechinatine N-oxide; Boraginaceae; Solenantus lanatus; anti-AChE activity; pyrrolizidine alkaloids