title: Obese Patients With a Binge Eating Disorder Have an Unfavorable Metabolic and Inflammatory Profile.
abstract: To evaluate whether obese patients with a binge eating disorder (BED) have an altered metabolic and inflammatory profile related to their eating behaviors compared with non-BED obese.A total of 115 White obese patients consecutively recruited underwent biochemical, anthropometrical evaluation, and a 75-g oral glucose tolerance test. Patients answered the Binge Eating Scale and were interviewed by a psychiatrist. The patients were subsequently divided into 2 groups according to diagnosis: non-BED obese (n = 85) and BED obese (n = 30). Structural equation modeling analysis was performed to elucidate the relation between eating behaviors and metabolic and inflammatory profile.BED obese exhibited significantly higher percentages of altered eating behaviors, body mass index (P < 0.001), waist circumference (P < 0.01), fat mass (P < 0.001), and a lower lean mass (P < 0.001) when compared with non-BED obese. Binge eating disorder obese also had a worse metabolic and inflammatory profile, exhibiting significantly lower high-density lipoprotein cholesterol levels (P < 0.05), and higher levels of glycated hemoglobin (P < 0.01), uric acid (P < 0.05), erythrocyte sedimentation rate (P < 0.001), high-sensitive C-reactive protein (P < 0.01), and white blood cell counts (P < 0.01). Higher fasting insulin (P < 0.01) and higher insulin resistance (P < 0.01), assessed by homeostasis model assessment index and visceral adiposity index (P < 0.001), were observed among BED obese. All differences remained significant after adjusting for body mass index. No significant differences in fasting plasma glucose or 2-hour postchallenge plasma glucose were found. Structural equation modeling analysis confirmed the relation between the altered eating behaviors of BED and the metabolic and inflammatory profile.Binge eating disorder obese exhibited an unfavorable metabolic and inflammatory profile, which is related to their characteristic eating habits.
authors.affiliation: From the Department of Medical and Surgical Sciences (ES, MR, GS, FA) and the Department of Health Sciences (CS-G, MC, MR, MA, PDF), University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Succurro
authors.forename: Cristina
authors.initials: C
authors.lastname: Segura-Garcia
authors.forename: Mariafrancesca
authors.initials: M
authors.lastname: Ruffo
authors.forename: Mariarita
authors.initials: M
authors.lastname: Caroleo
authors.forename: Marianna
authors.initials: M
authors.lastname: Rania
authors.forename: Matteo
authors.initials: M
authors.lastname: Aloi
authors.forename: Pasquale
authors.initials: P
authors.lastname: De Fazio
authors.forename: Giorgio
authors.initials: G
authors.lastname: Sesti
authors.forename: Franco
authors.initials: F
authors.lastname: Arturi
mesh_terms: D000328:Adult; D056912:Binge-Eating Disorder / Q000150:complications / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007333:Insulin Resistance; D007406:Interview, Psychological / Q000379:methods; D007958:Leukocyte Count / Q000379:methods; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000175:diagnosis / Q000378:metabolism / Q000523:psychology; D013223:Statistics as Topic
chemical_list: D008076:Cholesterol, HDL; D002097:C-Reactive Protein