title: Antidepressants substantially affect basic REM sleep characteristics in narcolepsy-cataplexy patients.
abstract: OBJECTIVE
  Antidepressants substantially affect REM sleep characteristics and trigger manifestations of REM sleep behavior disorder (RBD) in the general, non-narcoleptic, population. Antidepressants are also frequently administrated in an attempt to suppress cataplexy. We investigated the role of antidepressants in the development of RBD in narcolepsy with cataplexy (NC) patients.
  
  
  METHODS
  Seventy-five patients diagnosed with NC were assessed by a structured interview (focused on RBD manifestations and the use of antidepressants) and night video-polysomnography followed by the multiple sleep latency test.
  
  
  RESULTS
  Of all 75 NC patients (36 male, 39 female; mean age 46.1±18.5 years), 34 cases had a history of antidepressant use (45.3%; 18 male, 16 female). In this antidepressant-positive group, 13 patients suffered from RBD (38.2%). Among antidepressant-naïve patients, only 5 subjects (12.2%) were diagnosed with RBD. Polysomnographic data showed significantly increased REM latency (p<0.01) and reduced percentage of REM sleep (p<0.01) in the antidepressant-positive group, as well as more periodic limb movements during sleep (p=0.01).
  
  
  CONCLUSIONS
  NC patients with a history of antidepressant use showed a three-fold higher occurrence of RBD in comparison to antidepressant-naïve patients.
authors.affiliation: Department of Neurology and Center for Clinical Neurosciences, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
authors.forename: Jitka
authors.initials: J
authors.lastname: Busková
authors.affiliation: Department of Neurology and Center for Clinical Neurosciences, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Kemlink
authors.affiliation: Department of Neurology and Center for Clinical Neurosciences, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
authors.forename: Veronika
authors.initials: V
authors.lastname: Ibarburu
authors.affiliation: Department of Neurology and Center for Clinical Neurosciences, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
authors.forename: Sona
authors.initials: S
authors.lastname: Nevsímalová
authors.affiliation: Department of Neurology and Center for Clinical Neurosciences, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
authors.forename: Karel
authors.initials: K
authors.lastname: Sonka
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016022:Case-Control Studies; D015331:Cohort Studies; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology*; D017286:Polysomnography; D020187:REM Sleep Behavior Disorder / Q000139:chemically induced* / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors; D012895:Sleep, REM / Q000187:drug effects*; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents