title: Development of a device for detecting target specimens from EUS-guided FNA samples.
abstract: OBJECTIVE
  Specimens collected by fine needle are microscopic and contain blood; therefore, the presence of a target specimen within a sample is often difficult to confirm. Although rapid on-site evaluation (ROSE) during endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNA) is beneficial, many health care facilities are unable to apply this technique due to a lack of cytopathologists. The aim of this study was to develop and validate a device that detects the target specimen within pancreatic tumor EUS-FNA samples.
  
  
  METHODS
  Fifty-eight consecutive patients with solid pancreatic masses were studied for a preliminary case series at a tertiary-care university hospital (Tottori University Hospital, Yonago, Japan). The material collected was checked with a target sample check illuminator (TSCI) and was evaluated by one cytopathologist.
  
  
  RESULTS
  The agreement rate between the TSCI and histopathology was 93.7 %. Further testing procedures were not needed in 91.4 % of patients, and the mean number of needle punctures was 1.2 after a single pass using TSCI. No adverse events were encountered with the procedure.
  
  
  CONCLUSIONS
  With the introduction of the TSCI in EUS-FNA, it became possible to both collect the minimum necessary target samples by EUS-FNA and to end further procedures, even without performing ROSE.
authors.affiliation: Department of Gastroenterology, Tottori University Hospital, Yonago, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Center for Promoting Next-Generation Highly Advanced Medicine, Tottori University Hospital, Yonago, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Ueki
authors.affiliation: Department of Gastroenterology, Tottori University Hospital, Yonago, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Takeda
authors.affiliation: Department of Gastroenterology, Tottori University Hospital, Yonago, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Harada
authors.affiliation: Department of Gastroenterology, Tottori University Hospital, Yonago, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Onoyama
authors.affiliation: Department of Gastroenterology, Tottori University Hospital, Yonago, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Kawata
authors.affiliation: Department of Gastroenterology, Tottori University Hospital, Yonago, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ikebuchi
authors.affiliation: Department of Gastroenterology, Tottori University Hospital, Yonago, Japan.
authors.forename: Ryu
authors.initials: R
authors.lastname: Imamoto
authors.affiliation: Department of Pathology, Tottori University Hospital, Yonago, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Horie
authors.affiliation: Department of Gastroenterology, Tottori University Hospital, Yonago, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Murawaki