title: Malignant Melanocytic Matricoma: A Report of 2 Cases and Review of the Literature.
abstract: BACKGROUND
  To describe 2 cases of melanocytic matricoma with malignant histological features and systematically review previously reported cases of malignant melanocytic matricoma.
  
  
  METHODS
  Two cases of malignant melanocytic matricoma were identified from the practice of the authors. Additional 3 cases were identified in the literature. The clinical and pathological features of these 5 cases are described.
  
  
  RESULTS
  Malignant melanocytic matricoma occurs predominantly in sun-damaged skin of elderly individuals. The tumor is composed of atypical epithelial cells with brisk mitotic activity showing evidence of matrical keratinization and widespread positivity with beta-catenin. There is an admixed cytologically bland dendritic melanocytic component. To date, local recurrence has occurred in one case, but no cases of disseminated disease or death have been reported.
  
  
  CONCLUSIONS
  Recognition of this rare tumor and separation from a range of diagnostic mimics is important to ensure adequate treatment by local excision and to allow further cases to be identified to better define the biological potential of this lesion.
authors.affiliation: *Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Perth, Australia; †Histology Unit, Western Diagnostic Pathology, Perth, Australia; and ‡School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.
authors.forename: Nima Mesbah
authors.initials: NM
authors.lastname: Ardakani
authors.forename: David L G
authors.initials: DL
authors.lastname: Palmer
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Wood
mesh_terms: D000368:Aged; D005260:Female; D006201:Hair Diseases / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000473:pathology*; D009336:Necrosis / Q000473:pathology; D018296:Pilomatrixoma / Q000737:chemistry / Q000473:pathology*; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*; D051176:beta Catenin / Q000032:analysis
chemical_list: D051176:beta Catenin