title: NLR-regulated pathways in cancer: opportunities and obstacles for therapeutic interventions.
abstract: NLRs (nucleotide-binding domain, leucine-rich repeat containing receptors) are pattern recognition receptors associated with immunity and inflammation in response to endogenous and exogenous pathogen and damage associated molecular patterns (PAMPs and DAMPs respectively). Dysregulated NLR function is associated with several diseases including cancers, metabolic diseases, autoimmune disorders and autoinflammatory syndromes. In the last decade, distinct cell and organ specific roles for NLRs have been identified however; their roles in cancer initiation, development and progression remain controversial. This review summarizes the emerging role of NLRs in cancer and their possible future as targets for cancer therapeutics.
authors.affiliation: Department of Biology, Indian Institute of Technology Jodhpur, Old Residency Road, Ratanada, Jodhpur, Rajasthan, 342011, India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Sharma
authors.affiliation: Department of Biology, Indian Institute of Technology Jodhpur, Old Residency Road, Ratanada, Jodhpur, Rajasthan, 342011, India. sushmitajha@gmail.com.
authors.forename: Sushmita
authors.identifier: http://orcid.org/0000-0003-2336-5064
authors.initials: S
authors.lastname: Jha
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D053468:CARD Signaling Adaptor Proteins / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D000070576:NLR Proteins; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D051616:Neuronal Apoptosis-Inhibitory Protein / Q000378:metabolism
chemical_list: C410167:AIM2 protein, human; D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D053468:CARD Signaling Adaptor Proteins; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D058847:Inflammasomes; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; C496800:NAIP protein, human; D000070576:NLR Proteins; C503285:NLRC3 protein, human; C435692:NLRC4 protein, human; C427903:NLRP1 protein, human; C468563:NLRP6 protein, human; D051616:Neuronal Apoptosis-Inhibitory Protein
keywords: ASC; Caspase; Inflammasomes; Innate immunity; Interleukins; Therapeutics; Tumor microenvironment