title: DNA sequencing by two-dimensional materials: As theoretical modeling meets experiments.
abstract: Owing to their extraordinary electrical, chemical, optical, mechanical and structural properties, two-dimensional (2D) materials (mainly including graphene, boron nitride, MoS2etc.) have stimulated exploding interests in sensor applications. 2D-material based nanoscale DNA sequencing is a single-molecule technique with revolutionary potential. In this paper, we review the methodology of DNA sequencing based on the measurements of ionic current, force peak, and transverse electrical currents etc. by 2D materials. The advantages and disadvantages of DNA sequencing by 2D materials are discussed. Besides the recent development of experiments, we will focus on the theoretical calculations of DNA sequencing, which have been played a critical role in the development of this field. Special emphasis will focus on the disagreements between experiments and theoretical calculations, and the explanations for the discrepancy will be highlighted. Finally, some new plausible sequencing methods from computational studies will be discussed, which may be applied in the realistic DNA sequencing experiments in future.
authors.affiliation: Department of Chemistry and §Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Liang
authors.affiliation: School of Medicine, Hangzhou Normal University, Hangzhou 310016, People's Republic of China.
authors.forename: Jia-Wei
authors.initials: JW
authors.lastname: Shen
authors.affiliation: Research Institute for Soft Matter and Biomimetics, Department of Physics, Xiamen University, Xiamen 361005, People' s Republic of China.
authors.forename: Zhisen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Chemistry and §Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000818:Animals; D001483:Base Sequence; D001896:Boron Compounds / Q000737:chemistry; D003198:Computer Simulation; D004247:DNA / Q000032:analysis / Q000235:genetics*; D004220:Disulfides / Q000737:chemistry; D004867:Equipment Design; D006108:Graphite / Q000737:chemistry; D006801:Humans; D008957:Models, Genetic; D008958:Models, Molecular; D008982:Molybdenum / Q000737:chemistry; D058608:Nanopores / Q000648:ultrastructure; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods; D017422:Sequence Analysis, DNA / Q000295:instrumentation* / Q000379:methods
chemical_list: D001896:Boron Compounds; D004220:Disulfides; C017282:boron nitride; D006108:Graphite; D008982:Molybdenum; D004247:DNA; C082964:molybdenum disulfide
keywords: DNA sequence; Nanopore; Theoretical modeling; Two-dimensional material