title: Epigenetic Regulation of Epidermal Stem Cell Biomarkers and Their Role in Wound Healing.
abstract: As an actively renewable tissue, changes in skin architecture are subjected to the regulation of stem cells that maintain the population of cells responsible for the formation of epidermal layers. Stems cells retain their self-renewal property and express biomarkers that are unique to this population. However, differential regulation of the biomarkers can initiate the pathway of terminal cell differentiation. Although, pockets of non-clarity in stem cell maintenance and differentiation in skin still exist, the influence of epigenetics in epidermal stem cell functions and differentiation in skin homeostasis and wound healing is clearly evident. The focus of this review is to discuss the epigenetic regulation of confirmed and probable epidermal stem cell biomarkers in epidermal stratification of normal skin and in diseased states. The role of epigenetics in wound healing, especially in diseased states of diabetes and cancer, will also be conveyed.
authors.affiliation: Department of Biological Sciences, Alabama State University, Montgomery, AL 36104, USA. ssaldanha@alasu.edu.
authors.forename: Sabita N
authors.initials: SN
authors.lastname: Saldanha
authors.affiliation: Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA. kendroy@uab.edu.
authors.forename: Kendra J
authors.initials: KJ
authors.lastname: Royston
authors.affiliation: Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA. nehau@uab.edu.
authors.forename: Neha
authors.initials: N
authors.lastname: Udayakumar
authors.affiliation: Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA. trygve@uab.edu.|Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA. trygve@uab.edu.|Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA. trygve@uab.edu.|Center for Aging, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA. trygve@uab.edu.|Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA. trygve@uab.edu.
authors.forename: Trygve O
authors.initials: TO
authors.lastname: Tollefsbol
mesh_terms: D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation; D004817:Epidermis / Q000378:metabolism / Q000502:physiology*; D044127:Epigenesis, Genetic; D006801:Humans; D011506:Proteins / Q000235:genetics*; D013234:Stem Cells / Q000378:metabolism / Q000502:physiology*; D014945:Wound Healing / Q000235:genetics*
chemical_list: D015415:Biomarkers; D011506:Proteins
keywords: biomarkers; epidermal stem cells; epigenetics; microRNA; skin; wound healing