title: Translational In Vivo Models for Women's Health: The Nonhuman Primate Endometrium--A Predictive Model for Assessing Steroid Receptor Modulators.
abstract: Macaques and baboons display physiological responses to steroid hormones that are similar to those of women. Herein, we describe various uses of nonhuman primates for preclinical studies on menstruation, endometriosis, and as a model system to evaluate reproductive therapies and contraceptives. Our goal is to outline the strengths of the nonhuman primate model for studies leading to improved therapies for women.
authors.affiliation: Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, 505 N.W. 185th Ave., Beaverton, OR, 97006, USA. slaydeno@ohsu.edu.
authors.forename: Ov Daniel
authors.initials: OD
authors.lastname: Slayden
mesh_terms: D000818:Animals; D004717:Endometrium / Q000187:drug effects*; D005260:Female; D006801:Humans; D008598:Menstruation / Q000187:drug effects; D023421:Models, Animal; D011323:Primates; D011987:Receptors, Steroid / Q000037:antagonists & inhibitors*; D016387:Women's Health
chemical_list: D011987:Receptors, Steroid
keywords: Animal models; Endometriosis; Menstruation; Nonhuman primate; Progesterone receptor modulators