title: Cryptochromes Interact Directly with PIFs to Control Plant Growth in Limiting Blue Light.
abstract: Sun-loving plants have the ability to detect and avoid shading through sensing of both blue and red light wavelengths. Higher plant cryptochromes (CRYs) control how plants modulate growth in response to changes in blue light. For growth under a canopy, where blue light is diminished, CRY1 and CRY2 perceive this change and respond by directly contacting two bHLH transcription factors, PIF4 and PIF5. These factors are also known to be controlled by phytochromes, the red/far-red photoreceptors; however, transcriptome analyses indicate that the gene regulatory programs induced by the different light wavelengths are distinct. Our results indicate that CRYs signal by modulating PIF activity genome wide and that these factors integrate binding of different plant photoreceptors to facilitate growth changes under different light conditions.
authors.affiliation: Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: upedmale@salk.edu.
authors.forename: Ullas V
authors.initials: UV
authors.lastname: Pedmale
authors.affiliation: Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Genomic Analysis Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Shao-Shan Carol
authors.initials: SC
authors.lastname: Huang
authors.affiliation: Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Zander
authors.affiliation: Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Cole
authors.affiliation: Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Hetzel
authors.affiliation: Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, SE-901 83 Umeå, Sweden.
authors.forename: Karin
authors.initials: K
authors.lastname: Ljung
authors.affiliation: Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Departamento de Bioquímica e Biologia Molecular/BIOAGRO, National Institute of Science and Technology in Plant-Pest Interactions, Universidade Federal de Viçosa, 36570.000 Viçosa, Minas Gerais, Brazil.
authors.forename: Pedro A B
authors.initials: PAB
authors.lastname: Reis
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Priya
authors.initials: P
authors.lastname: Sridevi
authors.affiliation: Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Nito
authors.affiliation: Genomic Analysis Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Nery
authors.affiliation: Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Genomic Analysis Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Ecker
authors.affiliation: Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: chory@salk.edu.
authors.forename: Joanne
authors.initials: J
authors.lastname: Chory
mesh_terms: D017360:Arabidopsis / Q000254:growth & development / Q000378:metabolism* / Q000528:radiation effects; D029681:Arabidopsis Proteins / Q000378:metabolism*; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D056931:Cryptochromes / Q000378:metabolism*; D015870:Gene Expression; D018546:Hypocotyl / Q000254:growth & development; D008027:Light; D051939:Phytochrome B / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D051792:Basic Helix-Loop-Helix Proteins; D056931:Cryptochromes; D051939:Phytochrome B; C538962:CRY1 protein, Arabidopsis; C103618:CRY2 protein, Arabidopsis; C497952:PHYB protein, Arabidopsis; C459466:PIF4 protein, Arabidopsis; C497729:PIF5 protein, Arabidopsis