title: New insights on hormones and factors that modulate Sertoli cell metabolism.
abstract: Sertoli cells (SCs) play a key role in spermatogenesis by providing the physical support for developing germ cells and ensuring them the appropriate nutrients, energy sources, hormones, and growth factors. The control of SCs metabolism has been in the spotlight for reproductive biologists, since it may be crucial to determine germ cells' fate. Indeed, the maintenance of spermatogenesis is highly dependent on the metabolic cooperation established between SCs and germ cells, though this event has been overlooked. It depends on the orchestration of various metabolic pathways and an intricate network of signals. Several factors and/or hormones modulate the metabolic activity of SCs, which are major targets for the hormonal signalling that regulates spermatogenesis. Any alteration in the regulation of these cells' metabolic behaviour may compromise the normal development of spermatogenesis and consequently, male fertility. In this context, SC metabolism arises as a key regulation point for spermatogenesis. Herein, we present an up-to-date overview on the impact of hormones and factors that modulate SC metabolism, with special focus on glycolytic metabolism, highlighting their relevance in determining male reproductive potential.
authors.affiliation: CICS - UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
authors.forename: Luís
authors.initials: L
authors.lastname: Rato
authors.affiliation: Department of Microscopy, Laboratory of Cell Biology and Unit for Multidisciplinary Research in Biomedicine, Abel Salazar Institute of Biomedical Sciences, University of Porto - UMIB/ICBAS/UP, Porto, Portugal.
authors.forename: Maria João
authors.initials: MJ
authors.lastname: Meneses
authors.affiliation: CICS - UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
authors.forename: Branca M
authors.initials: BM
authors.lastname: Silva
authors.affiliation: Department of Microscopy, Laboratory of Cell Biology and Unit for Multidisciplinary Research in Biomedicine, Abel Salazar Institute of Biomedical Sciences, University of Porto - UMIB/ICBAS/UP, Porto and Centre for Reproductive Genetics Professor Alberto Barros,Porto, Portugal.
authors.forename: Mário
authors.initials: M
authors.lastname: Sousa
authors.affiliation: CICS - UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal. alvesmarc@gmail.com.
authors.forename: Marco G
authors.initials: MG
authors.lastname: Alves
authors.affiliation: Department of Microscopy, Laboratory of Cell Biology and Unit for Multidisciplinary Research in Biomedicine, Abel Salazar Institute of Biomedical Sciences, University of Porto - UMIB/ICBAS/UP, Porto and I3S - Institute for Innovation and Health Research, University of Porto, Porto, Portugal. pfobox@gmail.com.
authors.forename: Pedro F
authors.initials: PF
authors.lastname: Oliveira
mesh_terms: D000818:Animals; D042341:Gonadal Hormones / Q000378:metabolism; D006801:Humans; D008297:Male; D012708:Sertoli Cells / Q000378:metabolism*; D013091:Spermatogenesis / Q000502:physiology*
chemical_list: D042341:Gonadal Hormones