title: Effects of treadmill exercise-intensity on short-term memory in the rats born of the lipopolysaccharide-exposed maternal rats.
abstract: Maternal infection is an important factor causing neonatal brain injury and later developmental disability. In the present study, we investigated the effects of treadmill exercise intensity on short-term memory, hippocampal neurogenesis, and expression of brain-derived neurotrophic factor (BDNF), and tyrosine kinase receptor B (TrkB) in the rats born of lipopolysaccharide (LPS)-exposed maternal rats. The rats were divided into six groups: control group, mild-intensity exercise group, moderate-intensity exercise group, maternal LPS-exposed group, maternal LPS-exposed and mild-intensity exercise group, maternal LPS-exposed and moderate-intensity exercise group. The rats in the exercise groups were forced to run on a treadmill for 30 min 5 times a week for 4 weeks. The exercise load consisted of running at the speed of 8 m/min for the mild-intensity exercise groups and 14 m/min for moderate-intensity exercise groups. The latency in the step-down avoidance task was deter-mined for the short-term memory. Immunohistochemistry for 5-bro-mo-2'-deoxyuridine was performed to determine hippocampal cell proliferation and neurogenesis. Western blot analysis was performed for the detection of BDNF and TrkB expression. In the present study, tread-mill exercise improved short-term memory deteriorated by maternal LPS exposure. Treadmill exercise increased cell proliferation and neurogenesis in the hippocampal dentate gyrus of the rats born of the LPS-exposed maternal rats. Treadmill exercise increased BDNF and TrkB expression in the hippocampus of the rats born of the LPS-exposed maternal rats. These effects of treadmill exercise were similarly appeared at both mild-intensity and moderate-intensity.
authors.affiliation: School of Exercise & Sport Science, College of Natural Sciences, University of Ulsan, Ulsan, Korea.
authors.forename: Kijeong
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Physical Therapy, College of Natural Science, Kyungnam University, Changwon, Korea.
authors.forename: Yun-Hee
authors.initials: YH
authors.lastname: Sung
authors.affiliation: Division of Sports Science, Baekseok University, Cheonan, Korea.
authors.forename: Jin-Hee
authors.initials: JH
authors.lastname: Seo
authors.affiliation: Department of Physical Education, Korea Military Academy, Seoul, Korea.
authors.forename: Sang-Won
authors.initials: SW
authors.lastname: Lee
authors.affiliation: Division of Leisure & Sports Science, Department of Exercise Prescription, Dongseo University, Busan, Korea.
authors.forename: Baek-Vin
authors.initials: BV
authors.lastname: Lim
authors.affiliation: Department of Oriental Physiology, Gachon University College of Oriental Medicine, Seongnam, Korea.
authors.forename: Choong-Yeol
authors.initials: CY
authors.lastname: Lee
authors.affiliation: Department of Golf Mapping, College of Arts Physical Education, Joongbu University, Geumsan, Korea.
authors.forename: Yong-Rak
authors.initials: YR
authors.lastname: Chung
keywords: Brain-derived neurotrophic factor; Maternal infection; Neurogenesis; Short-term memory; Treadmill exercise; Tyrosine kinase receptor B