title: Drug Induced Lupus Erythematosus Due to Capecitabine and Bevacizumab Treatment Presenting with Prolonged Thrombocytopenia.
abstract: Drug induced lupus erythematosus (DLE) is a syndrome that is formed by lupus-like symptoms and laboratory characteristics. Capecitabine is an orally administered tumor-selective fluoropyrimidine that acts as a prodrug of 5-Fluorouracil and bevacizumab is an antivascular endothelial growth factor (anti-VEGF) antibody, both are used for the treatment of patients with colorectal cancer. Herein we report the first case of DILE in a 68-year-old woman who presented with arthralgia, myalgia and prolonged thrombocytopenia after receiving capecitabine and bevacizumab combination treatment as palliative treatment for metastatic colon cancer. Platelet-levels were increased and joint complaints disappeared in the first week of hydroxychloroquine and methylprednisolone treatment after chemotherapy had been discontinued. In conclusion, physicians should be alert to the possibility of DILE in patients presenting with thrombocytopenia under a capecitabine and bevacizumab chemotherapy regimen.
authors.forename: Ersin
authors.initials: E
authors.lastname: Ozaslan
authors.forename: Eray
authors.initials: E
authors.lastname: Eroglu
authors.forename: Kevser
authors.initials: K
authors.lastname: Gok
authors.forename: Soner
authors.initials: S
authors.lastname: Senel
authors.forename: Suleyman
authors.initials: S
authors.lastname: Baldane
authors.forename: Lutfi
authors.initials: L
authors.lastname: Akyol
authors.forename: Metin
authors.initials: M
authors.lastname: Ozkan
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary; D000368:Aged; D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D000068258:Bevacizumab / Q000009:adverse effects*; D000069287:Capecitabine / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000175:diagnosis; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D020533:Angiogenesis Inhibitors; D000964:Antimetabolites, Antineoplastic; D000068258:Bevacizumab; D000069287:Capecitabine