title: Study of the Determinants of Vitamin D Status in Pediatric Patients With Osteogenesis Imperfecta.
abstract: Vitamin D is essential to the development and maintenance of the skeleton, especially for children with bone disorders such as osteogenesis imperfecta (OI). We evaluated serum 25-hydroxyvitamin D (25-OHD) levels to assess the relationship between determinants of vitamin D status in pediatric patients with OI.
  
  
  
  This cross-sectional study evaluated sex, age, weight, height, body mass index, OI type, sunscreen use, season of assessment, sun exposure, vitamin D and calcium supplementation, bisphosphonate treatment, bone mineral density (BMD), milk and soda consumption, mobility, and time of sedentary activity. Levels of serum 25-OHD, calcium, parathyroid hormone (PTH), phosphorus, and alkaline phosphatase (ALP) were analyzed. Serum levels of 25-OHD were classified according to sufficient (>30 ng/ml or 75 nmol/L), insufficient (20-30 ng/ml or 50-75 nmol/L), moderately deficient (20-10 ng/ml or 50-25 nmol/L), and severely deficient (<10 ng/ml or 25 nmol/L).
  
  
  
  Fifty-two patients were included and 46 (88.4%) were classified as having insufficient or deficient 25-OHD. An inverse correlation between serum 25-OHD and time of sedentary activity (r = -0.597, p < 0.001) and a positive correlation with height (r = 0.521, p = 0.046) and whole body BMD (r = 0.586, p = 0.022) were observed. A significant difference between the number of glasses of milk consumed (p = 0.010) was observed.
  
  
  
  To optimize bone health, patients with OI need to be educated regarding habits that can improve serum 25-OHD levels, such as a reduction in periods of inactivity, the importance of sun exposure, and increasing consumption of milk and fortified dairy products.
authors.affiliation: a PostGraduate Program in Child and Adolescent Health, University of Rio Grande do Sul , Porto Alegre , BRAZIL.
authors.forename: Marina B
authors.initials: MB
authors.lastname: Zambrano
authors.affiliation: a PostGraduate Program in Child and Adolescent Health, University of Rio Grande do Sul , Porto Alegre , BRAZIL.
authors.forename: Evelise
authors.initials: E
authors.lastname: Brizola
authors.affiliation: a PostGraduate Program in Child and Adolescent Health, University of Rio Grande do Sul , Porto Alegre , BRAZIL.
authors.forename: Bruna
authors.initials: B
authors.lastname: Pinheiro
authors.affiliation: a PostGraduate Program in Child and Adolescent Health, University of Rio Grande do Sul , Porto Alegre , BRAZIL.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Vanz
authors.affiliation: a PostGraduate Program in Child and Adolescent Health, University of Rio Grande do Sul , Porto Alegre , BRAZIL.|b Pediatric Service (E.D.M.), Medical Genetics Service (T.M.F.), Hospital de Clinicas of Porto Alegre , Porto Alegre , BRAZIL.
authors.forename: Elza D
authors.initials: ED
authors.lastname: Mello
authors.affiliation: a PostGraduate Program in Child and Adolescent Health, University of Rio Grande do Sul , Porto Alegre , BRAZIL.|b Pediatric Service (E.D.M.), Medical Genetics Service (T.M.F.), Hospital de Clinicas of Porto Alegre , Porto Alegre , BRAZIL.
authors.forename: Têmis Maria
authors.initials: TM
authors.lastname: Félix
mesh_terms: D000818:Animals; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003611:Dairy Products; D004032:Diet; D019587:Dietary Supplements; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D008892:Milk; D009752:Nutritional Status; D010013:Osteogenesis Imperfecta / Q000097:blood* / Q000150:complications; D010281:Parathyroid Hormone / Q000097:blood; D013472:Sunlight; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000150:complications
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: bone health; family education; health professional; nutrition; osteogenesis imperfecta; vitamin D