title: COX-2 inhibitors: a novel strategy in the management of breast cancer.
abstract: Cyclooxygenase-2 (COX-2) inhibitors are common anti-inflammatory drugs with pleiotropic, endogenous actions that could be useful in the management of breast cancer. Here, we provide a complete understanding of the biochemistry of COX-2 and discuss the various molecular mechanisms behind its increased expression in breast cancer. We also analyze the possible mechanisms responsible for the anticancer effect of COX-2 inhibitors and provide an overview of the available preclinical and clinical data on the use of COX-2 inhibitors in breast cancer. Finally, we describe a mathematical model of the relation between the structure and biological potency of promising new COX-2 inhibitors (trans-stilbenes) using a 2D quantitative structure-activity relationship (QSAR) technique.
authors.affiliation: Poznan University of Medical Sciences, Chair and Department of Toxicology, 30th Dojazd Street, 60-631 Poznań, Poland.
authors.forename: Miłosz
authors.initials: M
authors.lastname: Regulski
authors.affiliation: Greater Poland Oncology Center, 15th Garbary Street, 61-866 Poznań, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Regulska
authors.affiliation: Adam Mickiewicz University in Poznań, Faculty of Chemistry, Nucleosides and Nucleotides Chemistry, 6th Grunwaldzka Street, 60-780 Poznan, Poland.
authors.forename: Wiesław
authors.initials: W
authors.lastname: Prukała
authors.affiliation: Poznan University of Medical Sciences, Chair and Department of Toxicology, 30th Dojazd Street, 60-631 Poznań, Poland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Piotrowska
authors.affiliation: Poznan University of Medical Sciences, Chair and Department of Pharmaceutical Chemistry, 6th Grunwaldzka Street, 60-780 Poznań, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Stanisz
authors.affiliation: Poznan University of Medical Sciences, Chair and Department of Toxicology, 30th Dojazd Street, 60-631 Poznań, Poland. Electronic address: marek.murias@ump.edu.pl.
authors.forename: Marek
authors.initials: M
authors.lastname: Murias
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000737:chemistry / Q000378:metabolism; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011453:Prostaglandins / Q000378:metabolism; D021281:Quantitative Structure-Activity Relationship; D013931:Thromboxanes / Q000378:metabolism
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D011453:Prostaglandins; D013931:Thromboxanes; D051546:Cyclooxygenase 2