title: Structural and functional changes in the zebrafish (Danio rerio) skeletal muscle after cadmium exposure.
abstract: This report describes the alterations induced by an environmentally realistic concentration of cadmium in skeletal muscle fibre organization, composition, and function in the teleost zebrafish. Results demonstrate that the ion induces a significant quantitative and qualitative deterioration, disrupting sarcomeric pattern and altering glycoprotein composition. These events, together with a mitochondrial damage, result in a significant reduction in swimming performance. In conclusion, the evidence here collected indicate that in presence of an environmental cadmium contamination, important economic (yields in fisheries/aquaculture), consumer health (fish is an important source of proteins), and ecological (reduced fitness due to reduced swimming performance) consequences can be expected.
authors.affiliation: Department of Biology, University of Naples Federico II, Via Mezzocannone 8, Naples, 80134, Italy. bice.avallone@unina.it.
authors.forename: Bice
authors.identifier: http://orcid.org/0000-0002-5355-1557
authors.initials: B
authors.lastname: Avallone
authors.affiliation: Department of Biology, University of Naples Federico II, Via Mezzocannone 8, Naples, 80134, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Agnisola
authors.affiliation: Department of Biology, University of Naples Federico II, Via Mezzocannone 8, Naples, 80134, Italy.
authors.forename: Raimondo
authors.initials: R
authors.lastname: Cerciello
authors.affiliation: Department of Biology, University of Naples Federico II, Via Mezzocannone 8, Naples, 80134, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Panzuto
authors.affiliation: Department of Biophysics, GSI Helmholtz Center for Heavy Ion Research, Darmstadt, 64291, Germany.
authors.forename: Palma
authors.initials: P
authors.lastname: Simoniello
authors.affiliation: Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Cretì
authors.affiliation: Department of Biology, University of Naples Federico II, Via Mezzocannone 8, Naples, 80134, Italy.
authors.forename: Chiara Maria
authors.initials: CM
authors.lastname: Motta
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002104:Cadmium / Q000633:toxicity*; D002413:Cations, Divalent; D029941:Fish Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D006023:Glycoproteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology; D018485:Muscle Fibers, Skeletal / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D012518:Sarcomeres / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D013550:Swimming; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015027:Zebrafish
chemical_list: D002413:Cations, Divalent; D029941:Fish Proteins; D006023:Glycoproteins; D014874:Water Pollutants, Chemical; D002104:Cadmium
keywords: Behavioral tests; Cadmium; Lectins; Toxicity; Ucrit; Ultrastructure