title: Genetic variants in EBV reactivation-related genes and the risk and survival of breast cancer.
abstract: Tumor susceptibility gene 101 (TSG101) and activating transcription factor 2 (ATF2) have been suggested to involve in the reactivation of EBV which has implications in the development and progression of breast cancer. Therefore, the polymorphisms of TSG101 and ATF2 may associate with breast cancer risk and prognosis. A case-control study with 1551 breast cancer cases and 1605 age-matched controls were conducted in Guangzhou, China. We have also successfully followed up 1168 cases until December 31, 2014. The variant allele of TSG101 rs2292179 was associated with a non-significant reduced risk of breast cancer, particularly among women with BMI < 24 (kg/m(2)) (P for interaction <0.05). For ATF2 rs3845744, the variant allele was also associated with a significantly reduced breast cancer risk [odds ratio (OR) (95 % confidence interval (CI)) 0.86 (0.74∼1.00)], and the association occurred among only postmenopausal women [OR (95 % CI) 0.69 (0.54∼0.88)] (P for interaction <0.05). Breast cancer risk was further reduced with the increasing numbers of the variant G alleles of the two polymorphisms (P for trend <0.05). We did not find an overall association of the two loci with breast cancer prognosis, while the hazard ratios of the two loci (AG/GG vs. AA) were significantly higher among postmenopausal women than premenopausal women (P = 0.046, 0.016 for TSG101 rs2292179 and ATF2 rs3845744, respectively). In summary, the variant alleles of TSG101 rs2292179 and ATF2 rs3845744 were associated with a reduced risk of breast cancer, particularly for subjects with BMI <24 (kg/m(2)) and postmenopausal women, respectively. The two SNPs and menopausal status may have a significant interaction on breast cancer progression.
authors.affiliation: The School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: The School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China.|Aviation Hygiene Management Division, China Southern Airlines Company Limited, 9/F, Kangda Building, 278 Airport Road, Guangzhou, China.
authors.forename: Zheng-Zheng
authors.initials: ZZ
authors.lastname: Zhang
authors.affiliation: The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.
authors.forename: Lu-Ying
authors.initials: LY
authors.lastname: Tang
authors.affiliation: The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Lin
authors.affiliation: The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
authors.forename: Feng-Xi
authors.initials: FX
authors.lastname: Su
authors.affiliation: The Sun Yat-Sen University Cancer Center, Guangzhou, 510080, China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Xie
authors.affiliation: School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. xuefensu@cuhk.edu.hk.
authors.forename: Xue-Fen
authors.initials: XF
authors.lastname: Su
authors.affiliation: The School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. renzef@mail.sysu.edu.cn.|Department of Statistics and Epidemiology, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou, 510080, China. renzef@mail.sysu.edu.cn.
authors.forename: Ze-Fang
authors.initials: ZF
authors.lastname: Ren
mesh_terms: D051698:Activating Transcription Factor 2 / Q000235:genetics*; D000328:Adult; D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality; D016022:Case-Control Studies; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D056827:Endosomal Sorting Complexes Required for Transport / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D014157:Transcription Factors / Q000235:genetics*; D014775:Virus Activation / Q000502:physiology*; D000099177:Tsg101 Protein
chemical_list: D051698:Activating Transcription Factor 2; D004268:DNA-Binding Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D014157:Transcription Factors; D000099177:Tsg101 Protein; C497105:ATF2 protein, human
keywords: ATF2; Breast cancer; Polymorphisms; Prognosis; TSG101