title: Chenopodium ambrosioides L. extract prevents bone loss.
abstract: OBJECTIVE
  To evaluate the effect of the Chenopodium ambrosioides L (mastruz) extract for preventing bone loss and bone metabolism in ovariectomized rats.
  
  
  METHODS
  Twelve rats were subjected to bilateral ovariectomy for inducing osteoporosis. After surgery, they were divided into two groups: Ovariectomy-control group (G1, n=6), receiving 0.5 ml distilled water by gavage for 30 days, and Ovariectomy plus mastruz group (G2, n=6), receiving 0.5 ml of the hydroalcoholic extract of mastruz at 10% concentration (50mg) daily, for the same period. Then, the blood of the animals was collected for further biochemical analysis (liver function) and tibia and liver were removed for histological and histomorphometric analyses.
  
  
  RESULTS
  The cortical bone was significantly larger in the G2 than G1, whereas G1 presented the highest amount of adipocytes in the bone marrow (p<0.05). The blood levels of aspartate aminotransferase, triglycerides and cholesterol were significantly higher, whereas globulin and lactate dehydrogenase were smaller in G2 than G1.
  
  
  CONCLUSIONS
  The hydroalcoholic extract of mastruz has effects on bone metabolism by changing blood proteins and enzymes and preventing both bone loss and the substitution of bone marrow cells by.
authors.affiliation: Department of Dentistry, Universidade Potiguar, Natal, RN, Brazil.
authors.forename: Ciro Dantas
authors.initials: CD
authors.lastname: Soares
authors.affiliation: Department of Medicine, UnP, Natal, RN, Brazil.
authors.forename: Maria Goretti Freire de
authors.initials: MG
authors.lastname: Carvalho
authors.affiliation: Department of Dentistry, UnP, Natal, RN, Brazil.
authors.forename: Rejane Andrade de
authors.initials: RA
authors.lastname: Carvalho
authors.affiliation: Department of Dentistry, Universidade Potiguar, Natal, RN, Brazil.
authors.forename: Sérgio Rodrigo Pereira
authors.initials: SR
authors.lastname: Trindade
authors.affiliation: Department of Dentistry, UnP, Natal, RN, Brazil.
authors.forename: Amália Cinthia Meneses do
authors.initials: AC
authors.lastname: Rêgo
authors.affiliation: Department of Dentistry, UnP, Natal, RN, Brazil.
authors.forename: Irami
authors.initials: I
authors.lastname: Araújo-Filho
authors.affiliation: School of Dentistry, Universidade de São Paulo, Brazil.
authors.forename: Márcia Martins
authors.initials: MM
authors.lastname: Marques
mesh_terms: D017667:Adipocytes / Q000648:ultrastructure; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015519:Bone Density / Q000187:drug effects*; D001854:Bone Marrow Cells / Q000378:metabolism; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D027464:Chenopodium ambrosioides / Q000737:chemistry*; D002784:Cholesterol / Q000097:blood; D005260:Female; D005269:Femur / Q000648:ultrastructure; D023421:Models, Animal; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control*; D010052:Ovariectomy / Q000009:adverse effects; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology*; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol; D001219:Aspartate Aminotransferases