title: Homocysteine and the C677T Gene Polymorphism of Its Key Metabolic Enzyme MTHFR Are Risk Factors of Early Renal Damage in Hypertension in a Chinese Han Population.
abstract: The combined hyperhomocysteinemia condition is a feature of the Chinese hypertensive population. This study used the case-control method to investigate the association between plasma homocysteine and the C677T gene polymorphism of its key metabolic enzyme, 5, 10-methylenetetrahydrofolate reductase (MTHFR), and early renal damage in a hypertensive Chinese Han population.A total of 379 adult essential hypertensive patients were selected as the study subjects. The personal information, clinical indicators, and the C677T gene polymorphism of MTHFR were texted. This study used the urine microalbumin/urine creatinine ratio (UACR) as a grouping basis: the hypertension without renal damage group (NRD group) and the hypertension combined with early renal damage group (ERD group).Early renal damage in the Chinese hypertensive population was associated with body weight, systolic pressure, diastolic pressure, urea nitrogen, serum creatinine, cystatin C, uric acid, aldosterone, and glomerular filtration rate. The homocysteine level and the UACR in the TT genotype group were higher than those in the CC genotype group. The binary logistic regression analysis results showed that after sex and age were adjusted, the MTHFR C677T gene polymorphism was correlated with early renal damage in hypertension in both the recessive model and in the additive model.Plasma homocysteine and the C677T gene polymorphism of its key metabolic enzyme MTHFR might be independent risk factors of early renal damage in the hypertensive Chinese Han population.
authors.affiliation: From the Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University (RX, GL, YY, JL); and Department of Medicine, Jinan Maternity and Child Care Hospital, Jinan, P.R. China (LY, DC, XX, LZ).
authors.forename: Lin
authors.initials: L
authors.lastname: Yun
authors.forename: Rui
authors.initials: R
authors.lastname: Xu
authors.forename: Guohua
authors.initials: G
authors.lastname: Li
authors.forename: Yucai
authors.initials: Y
authors.lastname: Yao
authors.forename: Jiamin
authors.initials: J
authors.lastname: Li
authors.forename: Dehong
authors.initials: D
authors.lastname: Cong
authors.forename: Xingshun
authors.initials: X
authors.lastname: Xu
authors.forename: Lihua
authors.initials: L
authors.lastname: Zhang
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D006710:Homocysteine / Q000097:blood / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D006710:Homocysteine; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)