title: Multilayer sodium alginate beads with porous core containing chitosan based nanoparticles for oral delivery of anticancer drug.
abstract: To develop efficient and safe anticancer drug doxorubicin hydrochloride (DOX) delivery system for oral chemotherapy, chitosan based nanoparticles (CS/CMCS-NPs) composed of chitosan (CS) and o-carboxymeymethy chitosan (CMCS) were immobilized in multilayer sodium alginate beads (NPs-M-Beads). Two kinds of NPs-M-Beads, with or without porous core, were respectively prepared by internal or external ionic gelation method. In the small intestine, the intact CS/CMCS-NPs were able to escape from porous-beads and sustained release the loading DOX. In vivo results showed that the DOX could be efficiently absorbed by small intestine of SD rat and the higher concentration of the DOX in major organs of rats were found after oral administration of Porous-Beads, which were about 2-4 folds higher than that of non-porous-beads. These results suggested that the NPs-M-Beads with porous core to be exciting and promising for oral delivery of DOX.
authors.affiliation: College of Marine Life Science, Ocean University of China, Qingdao 266003, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Qingdao Municipal Hospital, Qingdao 266003, PR China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Jiang
authors.affiliation: College of Marine Life Science, Ocean University of China, Qingdao 266003, PR China.
authors.forename: Xuqian
authors.initials: X
authors.lastname: Lang
authors.affiliation: College of Marine Life Science, Ocean University of China, Qingdao 266003, PR China.
authors.forename: Ming
authors.initials: M
authors.lastname: Kong
authors.affiliation: College of Marine Life Science, Ocean University of China, Qingdao 266003, PR China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Cheng
authors.affiliation: College of Marine Life Science, Ocean University of China, Qingdao 266003, PR China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Marine Life Science, Ocean University of China, Qingdao 266003, PR China. Electronic address: fengchao@ouc.edu.cn.
authors.forename: Chao
authors.initials: C
authors.lastname: Feng
authors.affiliation: College of Marine Life Science, Ocean University of China, Qingdao 266003, PR China. Electronic address: xgchen@ouc.edu.cn.
authors.forename: Xiguang
authors.initials: X
authors.lastname: Chen
mesh_terms: D000284:Administration, Oral; D000464:Alginates / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008297:Male; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D051381:Rats; D014018:Tissue Distribution
chemical_list: D000464:Alginates; D000970:Antineoplastic Agents; D004337:Drug Carriers; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D048271:Chitosan
keywords: Chitosan; External crosslinking; Internal crosslinking; Porous-beads; Sustained release