title: Topical anti-inflammatory activity of Solanum corymbiflorum leaves.
abstract: Solanum corymbiflorum is popularly known as "baga-de-veado" and its leaves are applied on inflamed legs, scabies, tick bite, boils, mastitis, low back pain and otitis. The aim of this study was evaluate anti-inflammatory in vivo activity and relate this activity with antioxidant compounds present in the extract of S. corymbiflorum leaves. The extract from S. corymbiflorum leaves topically applied was able to reduce the croton oil-induced ear edema and myeloperoxidase (MPO) activity with maximum inhibition of 87±3% and 45±7%, rescpectively in the dose of 1mg/ear. Similar results were found for positive control dexamethasone, which presented inhibitions of ear edema and MPO activity of 89±3% and 50±3%, respectively in a dose of 0.1mg/ear. These findings are due, at least in part, the presence of polyphenols (195.28mg GAE/g) and flavonoids, as chlorogenic acid (59.27mg/g), rutin (12.72mg/g), rosmarinic acid, caffeic acid and gallic acid found by high performance liquid chromatography (HPLC) analysis. This species showed potencial antioxidant by 1,1-diphenyl-2-picrylhydrazyl (DPPH), and carbonyl groups in proteins methods which may be related with the presence of this compounds. This species possess anti-inflammatory activity confirming their popular use for the local treatment of skin inflammatory disorders.
authors.affiliation: Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Camobi Campus, Santa Maria, RS 97105-900, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Piana
authors.affiliation: Graduate Program in Biological Sciences: Toxicological Biochemistry, Federal University of Santa Maria, Camobi Campus, Santa Maria, RS 97105-900, Brazil.
authors.forename: Camila
authors.initials: C
authors.lastname: Camponogara
authors.affiliation: Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Camobi Campus, Santa Maria, RS 97105-900, Brazil.
authors.forename: Aline Augusti
authors.initials: AA
authors.lastname: Boligon
authors.affiliation: Graduate Program in Pharmaceutical Sciences, Federal University of Pampa-UNIPAMPA, Uruguaiana, RS 97500-970, Brazil.
authors.forename: Michel Mansur
authors.initials: MM
authors.lastname: Machado
authors.affiliation: Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Camobi Campus, Santa Maria, RS 97105-900, Brazil.
authors.forename: Thiele Faccim
authors.initials: TF
authors.lastname: de Brum
authors.affiliation: Graduate Program in Biological Sciences: Toxicological Biochemistry, Federal University of Santa Maria, Camobi Campus, Santa Maria, RS 97105-900, Brazil. Electronic address: saramarchesan@hotmail.com.
authors.forename: Sara Marchesan
authors.initials: SM
authors.lastname: Oliveira
authors.affiliation: Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Camobi Campus, Santa Maria, RS 97105-900, Brazil.
authors.forename: Liliane
authors.initials: L
authors.lastname: de Freitas Bauermann
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D001713:Biphenyl Compounds; D002851:Chromatography, High Pressure Liquid; D003907:Dexamethasone / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005419:Flavonoids / Q000032:analysis; D008297:Male; D051379:Mice; D009195:Peroxidase / Q000378:metabolism; D010851:Picrates; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D059808:Polyphenols / Q000032:analysis; D050050:Protein Carbonylation / Q000187:drug effects; D032322:Solanum / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D005419:Flavonoids; D010851:Picrates; D010936:Plant Extracts; D059808:Polyphenols; D003907:Dexamethasone; C004931:1,1-diphenyl-2-picrylhydrazyl; D009195:Peroxidase
keywords: Anti-inflammatory activity; Antioxidant activity; Baga-de-veado; Solanum corymbiflorum