title: A rare case of isoniazid-induced erythroderma.
abstract: Tuberculosis is a common infectious disease in developing countries. Isoniazid is established the first-line antitubercular drug and an essential component of all antitubercular regimens. Erythroderma caused by isoniazid is an uncommon but serious adverse drug reaction. We report here a case of a 63-year-old female patient who presented with generalized redness and scaling with itching after 8 weeks of antitubercular treatment (ATT). ATT was stopped immediately, and antihistaminics were started. The patient improved over a period of 2 weeks. On sequential rechallenge, she developed similar lesions all over the body with isoniazid, hence confirming the diagnosis of isoniazid-induced erythroderma.
authors.affiliation: Department of Pharmacology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors.forename: Yashika
authors.initials: Y
authors.lastname: Garg
authors.affiliation: Department of Pharmacology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors.forename: Rajeshwari
authors.initials: R
authors.lastname: Gore
authors.affiliation: Department of Dermatology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors.forename: Sourabh
authors.initials: S
authors.lastname: Jain
authors.affiliation: Department of Pharmacology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003873:Dermatitis, Exfoliative / Q000209:etiology* / Q000517:prevention & control; D023801:Directly Observed Therapy; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D004359:Drug Therapy, Combination / Q000009:adverse effects; D005260:Female; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D011537:Pruritus / Q000209:etiology* / Q000517:prevention & control; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D006633:Histamine Antagonists; D007538:Isoniazid
keywords: Adverse cutaneous drug reaction; erythroderma; isoniazid