title: In vivo MR spectroscopy of human breast tissue: quantification of fatty acid composition at a clinical field strength (3 T).
abstract: OBJECTIVE
  To evaluate the feasibility of in vivo measurement of the fatty acid (FA) composition of breast adipose tissue by MRS on a clinical platform.
  
  
  METHODS
  MRS experiments were performed at 3 T, using a STEAM sequence, on 25 patients diagnosed with breast cancer. MR spectra, acquired on healthy breast tissue, were analysed with the LCModel.
  
  
  RESULTS
  The measured values of the saturated fatty acid (SFA), mono-unsaturated fatty acid (MUFA) and poly-unsaturated fatty acid (PUFA) fractions were 23.8 ± 7.1%, 55.4 ± 6.8% and 20.8 ± 4.4%, respectively. The values of SFA, MUFA and PUFA observed in the current study are in the same range as those found in two previous studies performed at 7 T.
  
  
  CONCLUSIONS
  The results of the current study show that it is possible to quantify the fatty acid composition of breast tissue in vivo in a clinical setting (3 T).
authors.affiliation: Université de Rennes 1, 35000, Rennes, France. amandine.coum@gmail.com.|LTSI, INSERM, UMR 1099, 35000, Rennes, France. amandine.coum@gmail.com.
authors.forename: Amandine
authors.initials: A
authors.lastname: Coum
authors.affiliation: Département de Gynécologie, CHRU de Tours, 37044, Tours, France.|INSERM U1069, 37044, Tours, France.|Université François-Rabelais, 37044, Tours, France.
authors.forename: Lobna
authors.initials: L
authors.lastname: Ouldamer
authors.affiliation: Université de Rennes 1, 35000, Rennes, France.|LTSI, INSERM, UMR 1099, 35000, Rennes, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Noury
authors.affiliation: Université François-Rabelais, 37044, Tours, France.|INSERM U930, 37044, Tours, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Barantin
authors.affiliation: Département de Radiologie, CHRU de Tours, 37044, Tours, France.
authors.forename: Aymeric
authors.initials: A
authors.lastname: Saint-Hilaire
authors.affiliation: Département de Radiologie, CHRU de Tours, 37044, Tours, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Vilde
authors.affiliation: INSERM U1069, 37044, Tours, France.|Université François-Rabelais, 37044, Tours, France.|Département d'Oncologie, CHRU de Tours, 37044, Tours, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Bougnoux
authors.affiliation: Université de Rennes 1, 35000, Rennes, France.|LTSI, INSERM, UMR 1099, 35000, Rennes, France.
authors.forename: Giulio
authors.initials: G
authors.lastname: Gambarota
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000368:Aged; D014408:Biomarkers, Tumor / Q000737:chemistry; D001940:Breast / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000473:pathology; D005227:Fatty Acids / Q000737:chemistry*; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry; D005231:Fatty Acids, Unsaturated / Q000737:chemistry; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D012984:Software
chemical_list: D014408:Biomarkers, Tumor; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated
keywords: Breast cancer; Fatty acid; MRS; Quantification