title: [Diagnose pituitary adenoma using dynamic enhanced MRI: a quantitative approach].
abstract: OBJECTIVE
  To evaluate the diagnostic value of quantitative Dynamic Contrast Enhanced MRI analysis on pituitary adenoma.
  
  
  METHODS
  With the standard of pathology and follow-up results, 67 cases of microadenoma, 20 cases of macroadenoma and 15 cases of normal pituitary were selected and taken routine scanning, meanwhile the dynamic contrast-enhanced scanning was performed, then the characteristics of lesions on conventional images were analyzed, and the mean permeability parameters were measured, including transfer rate (K(trans)), back flux rate (Kep), fractional EES volume (Ve) using Tofts model, which were compared with each other among those three groups and between prolactinoma and somatotroph adenoma; finally, the areas under the ROC curve of permeability parameters were compared.
  
  
  RESULTS
  61 cases of 67 cases of pituitary adenoma could be diagnosed by conventional methods, therefore the diagnostic accuracy was 91.1%. The K(trans), Kep and Ve values were(0.90 ± 0.23)/min, (1.14 ± 0.58)/min, 1.02 ± 0.51 respectively in normal pituitary, and (0.46 ± 0.23)/min, (0.80 ± 0.27)/min, 0.73 ± 0.32 in microadenoma and (0.41 ± 0.25)/min, (0.71 ± 0.48)/min, 0.66 ± 0.40 in macroadenoma. The K(trans) and Kep in normal adenoma were respectively higher than in microadenoma and macroadenoma, and the difference had statistical significance (P < 0.05), while the Ve value among these three groups had no statistical significance; the K(trans) in prolactinoma was higher than in somatotroph adenoma, and the difference had statistical significance(P < 0.05), while the difference of Kep and Ve between prolactinoma and somatotroph adenoma had no statistical significance. The area under the ROC curve in finding the microadenoma, K(trans), Kep were 0.915 and 0.738, and the sensitivity of K(trans) and Kep were 92.3% and 53.8%, and the specificity of K(trans) and Kep were 85% and 100%.
  
  
  CONCLUSIONS
  Dynamic contrast-enhanced quantitative parameters, K(trans) and Kep are help to the diagnosis of pituitary adenoma, and K(trans) exhibits a relatively high diagnostic efficacy, and the value of diagnosis in K(trans) is higher than which in MRI conventional method; while K(trans) can differentiate certain secreting type of pituitary microadenoma.
authors.affiliation: Department of Radiology, First Affliated Hospital, Wannan Medical College, Wuhu 241000, China.
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Department of Radiology, First Affliated Hospital, Wannan Medical College, Wuhu 241000, China; Email: yjszhaij@126.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhai
authors.affiliation: Department of Radiology, First Affliated Hospital, Wannan Medical College, Wuhu 241000, China.
authors.forename: Yuanjun
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000236:Adenoma; D003287:Contrast Media; D006801:Humans; D008279:Magnetic Resonance Imaging; D010911:Pituitary Neoplasms; D015175:Prolactinoma; D012372:ROC Curve
chemical_list: D003287:Contrast Media