title: [Effects of thrombolytic therapy in patients with cardiac arrest from suspected pulmonary thromboembolism].
abstract: OBJECTIVE
  To explore the effects of thrombolytic therapy with recombinant tissue-type plasminogen activator (rt-PA) in patients with cardiac arrest from suspected pulmonary thromboembolism (PTE).
  
  
  METHODS
  A total of 12 hospitalized patients with cardiac arrest from suspected pulmonary embolism at Beijing Chaoyang Hospital from January 2010 to June 2014 were retrospectively studied. Thrombolysis was given only as a single dose of 50 mg of rt-PA during cardiopulmonary resuscitation. And their clinical features, effocacies and outcomes of thrombolysis were analyzed.
  
  
  RESULTS
  There were 6 males and 6 females with a mean age of (54.8±18.6) (16-81) years. Seven patients were hospitalized in surgery ward while another 6 perioperatively. The mean time of resuscitation before thrombolysis was (47.8±26.0) (17-90) min. Nine patients regained spontaneous circulation. The mean time of restored spontaneous circulation was (15.8±5.4) (5-20). The 24-hour survival rate was 8/12. Four patients had bleeding complications, but only 2 life-threatening major cases. Four patients obtained a long-term survival.
  
  
  CONCLUSIONS
  For suspected PTE patients with sudden cardiac arrest, thrombolysis therapy with 50 mg of rt-PA may restore spontaneous circulation and boost 24-hour survival rate.
authors.affiliation: Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University; Beijing Key Laboratory of Respiratory & Pulmonary Circulation Disorders, Beijing 100020, China.
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University; Beijing Key Laboratory of Respiratory & Pulmonary Circulation Disorders, Beijing 100020, China; Email: zhaizhenguo2011@126.com.
authors.forename: Zhenguo
authors.initials: Z
authors.lastname: Zhai
authors.affiliation: Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University; Beijing Key Laboratory of Respiratory & Pulmonary Circulation Disorders, Beijing 100020, China.
authors.forename: Tuguang
authors.initials: T
authors.lastname: Kuang
authors.affiliation: Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University; Beijing Key Laboratory of Respiratory & Pulmonary Circulation Disorders, Beijing 100020, China.
authors.forename: Wanmu
authors.initials: W
authors.lastname: Xie
authors.affiliation: Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University; Beijing Key Laboratory of Respiratory & Pulmonary Circulation Disorders, Beijing 100020, China.
authors.forename: Yuanhua
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000068476:Beijing; D016887:Cardiopulmonary Resuscitation; D005260:Female; D006323:Heart Arrest; D006801:Humans; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism; D012189:Retrospective Studies; D015996:Survival Rate; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator; D055815:Young Adult
chemical_list: C067262:PLAT protein, human; D010959:Tissue Plasminogen Activator