title: [SOME CLINICAL AND CYTOKINE FEATURES OF THE CLINICAL COURSE OF RECURRENT RESPIRATORY SYSTEM DISEASES IN CHILDREN WITH THE TOXOCARIASIS INVASION].
abstract: The aim of the present study was to analyze clinical and cytokine features of recurrent respiratory system diseases in children with toxocariasis. 50 children aged 1 to 17 years (mean age - 10±5 years) with recurrent current of respiratory system disorders were studied. During the survey such clinical manifestations of the respiratory system disorders as obstructive bronchitis (50%), bronchial asthma (30%), pneumonia (10%) and laryngotracheitis (10%) have been revealed. Statistical analysis of the results was performed using the software package STATISTICA 6.1 (SNANSOFT). We have shown that the disorders of respiratory system in case of toxocariasis invasion often occur with severe intoxication and bronchial obstruction syndromes, temperature reaction, respiratory insufficiency and hepatomegaly. A prolonged course of the disease has been noted. "Inflammatory" indicators of general blood analysis, such as leukocytosis and increased of ESR have been recorded in patients with respiratory system disorders in children with T.canis infection significantly more often, significant "allergic" laboratory changes were in the form of eosinophilia. High average levels of pro-inflammatory IL-6, as well as low levels of IL 5 have been determined in children suffering from the respiratory system disorders and with toxocariasis invasion in the anamnesis. The obtained findings require further study.
authors.affiliation: Zaporozhye State Medical University, Ukraine.
authors.forename: A
authors.initials: A
authors.lastname: Dralova
authors.affiliation: Zaporozhye State Medical University, Ukraine.
authors.forename: E
authors.initials: E
authors.lastname: Usachova
mesh_terms: D000293:Adolescent; D000818:Animals; D000947:Antigens, Helminth / Q000097:blood / Q000276:immunology; D001249:Asthma / Q000097:blood / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D001991:Bronchitis / Q000097:blood / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004802:Eosinophilia / Q000097:blood / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D015848:Interleukin-5 / Q000097:blood / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology; D007827:Laryngitis / Q000097:blood / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D018410:Pneumonia, Bacterial / Q000097:blood / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D017166:Toxocara canis / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D014120:Toxocariasis / Q000097:blood / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D014136:Tracheitis / Q000097:blood / Q000150:complications / Q000276:immunology / Q000503:physiopathology*
chemical_list: D000947:Antigens, Helminth; C508599:IL5 protein, human; C508600:IL6 protein, human; D015848:Interleukin-5; D015850:Interleukin-6