title: Penetration of thyroliberin in the blood and brain regions at intranasal or intravenous administration.
abstract: The maximum amounts of the thyroliberin in the blood and brain of rats at intranasal and intravenous administration were determined. It is found that rat hippocampal, cortical, and cerebellar membranes contain two types of specific binding sites (high- and low-affinity) for the labeled ligand. It was shown that, at intranasal and intravenous administration, maximum amounts of the thyroliberin were detected in the cerebellum and then in the cortex and hippocampus. The degradation of the thyroliberin in the rat brain and its regions at intranasal and intravenous administration was studied. It is shown that the degree of degradation and the formation of proteolytic products of the thyroliberin is different in different regions of the rat brain.
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akademika Kurchatova 46, Moscow, 123182, Russia.
authors.forename: K V
authors.initials: KV
authors.lastname: Shevchenko
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akademika Kurchatova 46, Moscow, 123182, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Vyunova
authors.affiliation: Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agency, Ministry of Public Health of the Russian Federation, p/o Kuz'molovskii, Leningrad oblast, 188663, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Radilov
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akademika Kurchatova 46, Moscow, 123182, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akademika Kurchatova 46, Moscow, 123182, Russia.
authors.forename: I Yu
authors.initials: IY
authors.lastname: Nagaev
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akademika Kurchatova 46, Moscow, 123182, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Shevchenko
authors.affiliation: Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agency, Ministry of Public Health of the Russian Federation, p/o Kuz'molovskii, Leningrad oblast, 188663, Russia. gpech@fmbamail.ru.
authors.forename: V R
authors.initials: VR
authors.lastname: Rembovsky
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akademika Kurchatova 46, Moscow, 123182, Russia.
authors.forename: N F
authors.initials: NF
authors.lastname: Myasoedov
mesh_terms: D000281:Administration, Intranasal; D061605:Administration, Intravenous; D000818:Animals; D001921:Brain / Q000378:metabolism*; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D018696:Neuroprotective Agents; D013973:Thyrotropin-Releasing Hormone