title: Marine natural products with anti-inflammatory activity.
abstract: Chronic inflammation is believed to play crucial roles in the pathogenesis of various diseases. Several types of drugs are used to treat inflammatory disorders, but they cause adverse side effects. Natural products are alternatives to these drugs which offer hope for discovery of bioactive lead compounds that may be developed into drugs for treatment of inflammatory disorders. The biological and chemical diversity of marine habitats constitutes a sizeable reservoir of novel compounds. Some of them, like sesquiterpenoids, diterpenes, steroids, polysaccharides, alkaloids, fatty acids, proteins, and other chemical compounds, isolated from marine organisms are found to exhibit anti-inflammatory activity. This review reports some recent (2011-2015) investigations and examples of marine natural products and their synthetic derivatives with anti-inflammatory activity. It also highlights those compounds that are currently undergoing preclinical or clinical evaluation.
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Randy Chi Fai
authors.initials: RCF
authors.lastname: Cheung
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. b021770@mailserv.cuhk.edu.hk.
authors.forename: Tzi Bun
authors.initials: TB
authors.lastname: Ng
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Jack Ho
authors.initials: JH
authors.lastname: Wong
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Yangchao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. chanwy@cuhk.edu.hk.
authors.forename: Wai Yee
authors.initials: WY
authors.lastname: Chan
mesh_terms: D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D059001:Aquatic Organisms / Q000737:chemistry*; D001688:Biological Products / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D001688:Biological Products
keywords: Anti-inflammatory activity; Clinical trials; Marine natural products