title: The diagnostic accuracy of multiparametric MRI to determine pediatric brain tumor grades and types.
abstract: Childhood brain tumors show great histological variability. The goal of this retrospective study was to assess the diagnostic accuracy of multimodal MR imaging (diffusion, perfusion, MR spectroscopy) in the distinction of pediatric brain tumor grades and types. Seventy-six patients (range 1 month to 18 years) with brain tumors underwent multimodal MR imaging. Tumors were categorized by grade (I-IV) and by histological type (A-H). Multivariate statistical analysis was performed to evaluate the diagnostic accuracy of single and combined MR modalities, and of single imaging parameters to distinguish the different groups. The highest diagnostic accuracy for tumor grading was obtained with diffusion-perfusion (73.24%) and for tumor typing with diffusion-perfusion-MR spectroscopy (55.76%). The best diagnostic accuracy was obtained for tumor grading in I and IV and for tumor typing in embryonal tumor and pilocytic astrocytoma. Poor accuracy was seen in other grades and types. ADC and rADC were the best parameters for tumor grading and typing followed by choline level with an intermediate echo time, CBV for grading and Tmax for typing. Multiparametric MR imaging can be accurate in determining tumor grades (primarily grades I and IV) and types (mainly pilocytic astrocytomas and embryonal tumors) in children.
authors.affiliation: Service de Radiopédiatrie/Imagerie 2, CHU de Strasbourg-Hôpital de Hautepierre, 1 Avenue Molière, 67098, Strasbourg Cedex, France. meriam.koob@chru-strasbourg.fr.|Laboratoire ICube, UMR 7357/FMTS/Université de Strasbourg-CNRS, Strasbourg Cedex, France. meriam.koob@chru-strasbourg.fr.
authors.forename: Mériam
authors.identifier: http://orcid.org/0000-0002-3594-6272
authors.initials: M
authors.lastname: Koob
authors.affiliation: Service de Neuroradiologie Diagnostique et Interventionnelle, APHM Timone, 264, rue Saint Pierre, 13385, Marseille Cedex, France.|Aix*Marseille Université, CRMBM, UMR CNRS 7339, 13385, Marseille Cedex, France.
authors.forename: Nadine
authors.initials: N
authors.lastname: Girard
authors.affiliation: Département de Mathématiques, Faculté des Sciences de Luminy, 13385, Marseille, France.
authors.forename: Badih
authors.initials: B
authors.lastname: Ghattas
authors.affiliation: Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, USA.
authors.forename: Slim
authors.initials: S
authors.lastname: Fellah
authors.affiliation: Aix*Marseille Université, CRMBM, UMR CNRS 7339, 13385, Marseille Cedex, France.
authors.forename: Sylviane
authors.initials: S
authors.lastname: Confort-Gouny
authors.affiliation: Service d'Anatomie Pathologique et de Neuropathologie, APHM Timone, 264, rue Saint Pierre, 13385, Marseille Cedex 5, France.|Aix*Marseille Université, Inserm, CR02 UMR -S911, 13385, Marseille, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Figarella-Branger
authors.affiliation: Service de Neurochirurgie Pédiatrique, APHM Timone, 264, rue Saint Pierre, 13385, Marseille Cedex 5, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Scavarda
mesh_terms: D000293:Adolescent; D001254:Astrocytoma / Q000000981:diagnostic imaging / Q000473:pathology; D001932:Brain Neoplasms / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007223:Infant; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Brain neoplasms; Child; Diffusion magnetic resonance imaging; Magnetic resonance angiography; Magnetic resonance spectroscopy