title: A Comparison of Taste and Odor Perception in Pediatric Patients Receiving a 0.9% Sodium Chloride Flush From 2 Different Brands of Prefilled 0.9% Sodium Chloride Syringes.
abstract: The aim of this randomized single-blind study is to compare taste and odor disturbances in patients receiving 0.9% sodium chloride flushes from 2 brands. Seventy-five patients from 6 to 18 years of age received intravenous 0.9% sodium chloride infusions, and 50 healthy volunteers who tasted the 2 brands of 0.9% sodium chloride from prefilled syringes were assessed for taste and/or odor disturbances. Taste or odor disturbances were equally present in patients flushed with MedXL and Becton-Dickinson 0.9% sodium chloride. Disturbances are more frequent when 0.9% sodium chloride is flushed through central venous access devices than through peripheral catheters. No difference between the brands was found when healthy volunteers tasted it orally.
authors.affiliation: Octapharma France, Paris, France (Dr Hamze), and Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (Drs Vaillancourt and Villareal, and Ms Sharp). Benjamin Hamze, PharmD, is a pharmacien chargé affairs pharmaceutiques (regulatory affairs pharmacist) at Octapharma France in Lingolsheim, France. Régis Vaillancourt, OMM, CD, PharmD, BPharm, FCSHP, FFIP, is a clinical investigator at the Children's Hospital of Eastern Ontario Research Institute and the director of the Pharmacy Department at Children's Hospital of Eastern Ontario in Ottawa, Ontario, Canada. Diane Sharp, RN, is a vascular access-certified nurse and a care facilitator for the vascular access team at Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada. Gilda Villarreal, PhD, MHA, is a researcher in the Pharmacy Department of Children's Hospital of Eastern Ontario in Ottawa, Ontario, Canada.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Hamze
authors.forename: Régis
authors.initials: R
authors.lastname: Vaillancourt
authors.forename: Diane
authors.initials: D
authors.lastname: Sharp
authors.forename: Gilda
authors.initials: G
authors.lastname: Villarreal
mesh_terms: D000293:Adolescent; D000328:Adult; D002405:Catheterization, Central Venous; D002406:Catheterization, Peripheral; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009812:Odorants; D016037:Single-Blind Method; D012965:Sodium Chloride / Q000008:administration & dosage*; D013594:Syringes; D013649:Taste
chemical_list: D012965:Sodium Chloride