title: Disturbed spontaneous brain-activity pattern in patients with optic neuritis using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study.
abstract: OBJECTIVE
  To use the amplitude of low-frequency fluctuation (ALFF) technique to investigate the local features of spontaneous brain activity in optic neuritis (ON) and their relationship with behavioral performance.
  
  
  METHODS
  Twelve patients with ON (four male, eight female) and twelve age-, sex-, and education status-matched healthy controls (HCs) (four male, eight female) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. The ALFF technique was used to assess local features of spontaneous brain activity. Correlation analysis was used to explore the relationship between the observed mean ALFF values of the different areas and visual evoked potentials (VEPs) in patients with ON.
  
  
  RESULTS
  Compared with HCs, patients with ON had significantly decreased ALFF values in the posterior and anterior lobes of the right cerebellum, right putamen, right inferior frontal gyrus, right insula, right supramarginal gyrus, right inferior parietal lobule, left medial frontal gyrus, left superior temporal gyrus, bilateral anterior cingulate/medial frontal gyrus, and bilateral precuneus, and significantly increased ALFF values in the posterior lobes of the left and right cerebellum, right inferior temporal gyrus, right inferior temporal/fusiform gyrus, left parahippocampal gyrus, left fusiform gyrus, left calcarine fissure, left inferior parietal lobule, and left cuneus. We found negative correlations between the mean ALFF signal value of the left parahippocampal gyrus and the VEP amplitude of the right eye in ON (r=-0.584, P=0.046), and a positive correlation between the mean ALFF signal value of the bilateral precuneus and the best-corrected visual acuity of the left eye (r=0.579, P=0.048) in patients with ON.
  
  
  CONCLUSIONS
  ON mainly seems to involve dysfunction in the default-mode network, cerebellum, and limbic system, which may reflect the underlying pathologic mechanism of ON.
authors.affiliation: Department of Ophthalmology, Jiangxi Province Clinical Ophthalmology Institute, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China ; Department of Ophthalmology, First People's Hospital of Jiujiang, Jiujiang, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Feng-Qin
authors.initials: FQ
authors.lastname: Cai
authors.affiliation: Department of Ophthalmology, Jiangxi Province Clinical Ophthalmology Institute, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Pei-Hong
authors.initials: PH
authors.lastname: Hu
authors.affiliation: Department of Ophthalmology, Jiangxi Province Clinical Ophthalmology Institute, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Zhong
authors.affiliation: Department of Ophthalmology, Jiangxi Province Clinical Ophthalmology Institute, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, Jiangxi Province Clinical Ophthalmology Institute, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Rong
authors.initials: R
authors.lastname: Wei
authors.affiliation: Department of Ophthalmology, Jiangxi Province Clinical Ophthalmology Institute, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Chong-Gang
authors.initials: CG
authors.lastname: Pei
authors.affiliation: Department of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Fu-Qing
authors.initials: FQ
authors.lastname: Zhou
authors.affiliation: Department of Ophthalmology, Jiangxi Province Clinical Ophthalmology Institute, First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shao
keywords: ALFF; fMRI; optic neuritis; resting state; spontaneous activity; visual evoked potential