title: Impact of Statin Use on Development of New-Onset Diabetes Mellitus in Asian Population.
abstract: There have been several reports showing that the statin use is associated with new-onset diabetes mellitus (DM). The aim of the present study was to evaluate the impact of chronic statin use on development of new-onset DM in a series of Asian population. The patients were retrospectively enrolled using the electronic database of Korea University Guro Hospital from January 2004 to February 2010. A total of 10,994 patients without a history of diabetes were analyzed. Baseline lipid profiles, fasting glucose, Hemoglobin (Hb) A1c, and glucose tolerance tests were measured in all patients before statin treatment. Included patients had HbA1c ≤ 5.7% and fasting glucose level ≤ 100 (mg/dl). The patients were divided into 2 groups according to the use of statins (the statin group, n = 2,324 patients and the nonstatin group, n = 8,670 patients). To adjust baseline potential confounders, a propensity score-matched analysis was performed using logistic regression model. After propensity score matching, 2 propensity-matched groups (1,699 pairs, n = 3,398, C statistic = 0.859) were generated and analyzed. After propensity score matching, baseline characteristics of both groups were balanced except that the statin group was older and had higher rate of coronary artery disease compared with the nonstatin group. During a 3-year follow-up, the statin group had higher incidence of new-onset DM compared with the nonstatin group (hazard ratio 1.99, 95% CI 1.36 to 2.92, p <0.001), but the statin group showed lower incidence of major adverse cerebral-cardiovascular events compared with the nonstatin group (hazard ratio 0.40, 95% CI 0.19 to 0.85, p <0.001). In the present study, although the use of statins was associated with higher rate of new-onset DM, it markedly improved 3-year cardiovascular outcomes in Asian population.
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea. Electronic address: swrha617@yahoo.co.kr.
authors.forename: Seung-Woon
authors.initials: SW
authors.lastname: Rha
authors.affiliation: Department of Medicine, Korea University Graduate School, Seoul, Korea.
authors.forename: Byoung Geol
authors.initials: BG
authors.lastname: Choi
authors.affiliation: Material and Life Science Research Division, KU-KIST Graduate School Converging Science and Technology, Seoul, Korea.
authors.forename: Hong Seog
authors.initials: HS
authors.lastname: Seo
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Sang-Ho
authors.initials: SH
authors.lastname: Park
authors.affiliation: Department of Cardiology, Eulji University, Eulji General Hospital, Seoul, Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Park
authors.affiliation: Department of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Kang-Yin
authors.initials: KY
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Yoonjee
authors.initials: Y
authors.lastname: Park
authors.affiliation: Department of Medicine, Korea University Graduate School, Seoul, Korea.
authors.forename: Se Yeon
authors.initials: SY
authors.lastname: Choi
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Min-Suk
authors.initials: MS
authors.lastname: Shim
authors.affiliation: Department of Cardiology, Sejong General Hospital, Bucheon, Korea.
authors.forename: Ji Bak
authors.initials: JB
authors.lastname: Kim
authors.affiliation: Department of Cardiology, Weiss Memorial Hospital, Chicago, Illinois.
authors.forename: Taeshik
authors.initials: T
authors.lastname: Park
authors.affiliation: Department of Cardiology, Incheon Christian Hospital, Incheon, Korea.
authors.forename: Joonhyung
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Jae Joong
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Park
authors.affiliation: Department of Cardiology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
authors.forename: Sung Hun
authors.initials: SH
authors.lastname: Park
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Jah Yeon
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Sunki
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Jin Oh
authors.initials: JO
authors.lastname: Na
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Cheol Ung
authors.initials: CU
authors.lastname: Choi
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Hong Euy
authors.initials: HE
authors.lastname: Lim
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Eung Ju
authors.initials: EJ
authors.lastname: Kim
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Chang Gyu
authors.initials: CG
authors.lastname: Park
authors.affiliation: Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Dong Joo
authors.initials: DJ
authors.lastname: Oh
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D015994:Incidence; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D057216:Propensity Score; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids; C517652:hemoglobin A1c protein, human