title: A new flavane acid from the fruits of Illicium verum.
abstract: A new compound, illiciumflavane acid (1), along with 13 known compounds (2-14), were isolated from the fruits of Illicium verum Hook. F. Their structures were elucidated through various spectroscopic methods, including 1D NMR ((1)H NMR, (13)C NMR), 2D NMR (HMQC, HMBC and NOESY) and HRMS. The stereochemistry at the chiral centres was determined using CD spectrum as well as analyses of coupling constants and optical rotation data. Cytotoxicity evaluation of four compounds showed that illiciumflavane acid and (E)-1,2-bis(4-methoxyphenyl)ethene exhibited potential against A549 activities with IC50 values of 4.63 μM and 9.17 μM, respectively.
authors.affiliation: a Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Environment and Resource , Guangxi Normal University , Guilin , P. R. China.|b Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Ministry of Education of China) , Guilin , P. R. China.
authors.forename: Liang-Deng
authors.initials: LD
authors.lastname: Wu
authors.affiliation: a Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Environment and Resource , Guangxi Normal University , Guilin , P. R. China.|b Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Ministry of Education of China) , Guilin , P. R. China.
authors.forename: Chun-Lan
authors.initials: CL
authors.lastname: Xiong
authors.affiliation: a Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Environment and Resource , Guangxi Normal University , Guilin , P. R. China.|b Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Ministry of Education of China) , Guilin , P. R. China.
authors.forename: Zi-Zhan
authors.initials: ZZ
authors.lastname: Chen
authors.affiliation: a Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Environment and Resource , Guangxi Normal University , Guilin , P. R. China.|b Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Ministry of Education of China) , Guilin , P. R. China.
authors.forename: Rui-Jie
authors.initials: RJ
authors.lastname: He
authors.affiliation: a Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Environment and Resource , Guangxi Normal University , Guilin , P. R. China.|b Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Ministry of Education of China) , Guilin , P. R. China.
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Zhang
authors.affiliation: c Guangxi Key Laboratory of Tradtional Chinese Medicine Quality Standards , Nanning , P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: b Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Ministry of Education of China) , Guilin , P. R. China.
authors.forename: Sheng-Ping
authors.initials: SP
authors.lastname: Deng
authors.affiliation: b Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Ministry of Education of China) , Guilin , P. R. China.
authors.forename: Rui-Yun
authors.initials: RY
authors.lastname: Yang
authors.affiliation: a Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Environment and Resource , Guangxi Normal University , Guilin , P. R. China.|b Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Ministry of Education of China) , Guilin , P. R. China.|c Guangxi Key Laboratory of Tradtional Chinese Medicine Quality Standards , Nanning , P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D002945:Cisplatin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D029523:Illicium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009904:Optical Rotation
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; C000617281:illiciumflavane acid; D002945:Cisplatin
keywords: Illicium verum; cytotoxicity; illiciumflavane acid