title: The importance of surgical margins in retroperitoneal sarcoma.
abstract: Surgery is the "gold-standard" treatment for retroperitoneal sarcomas, but local recurrence is common, and can cause disease-related death. Complete gross resection is associated with improved survival, but debate exists as to whether resection of adjacent organs to improve margins or prescription of neoadjuvant radiation leads to better outcomes. This review summarizes data addressing prognostic value of margin, extent of surgery necessary to optimize treatment of retroperitoneal sarcomas, and role of histology in optimizing therapy.
authors.affiliation: Department of Surgery, Memorial Sloan Kettering Cancer Center, Gastric and Mixed Tumor Service, New York, New York.|Department of Surgery, Weill Cornell Medical School, New York, New York.
authors.forename: Amanda
authors.initials: A
authors.lastname: Kirane
authors.affiliation: Department of Surgery, Memorial Sloan Kettering Cancer Center, Gastric and Mixed Tumor Service, New York, New York.|Department of Surgery, Weill Cornell Medical School, New York, New York.
authors.forename: Aimee M
authors.initials: AM
authors.lastname: Crago
mesh_terms: D017024:Chemotherapy, Adjuvant; D006801:Humans; D007890:Leiomyosarcoma / Q000517:prevention & control / Q000601:surgery; D008080:Liposarcoma / Q000517:prevention & control / Q000601:surgery; D020360:Neoadjuvant Therapy / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D018365:Neoplasm, Residual / Q000517:prevention & control; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012186:Retroperitoneal Neoplasms / Q000473:pathology / Q000517:prevention & control* / Q000601:surgery*; D012509:Sarcoma / Q000473:pathology / Q000517:prevention & control* / Q000601:surgery*; D013514:Surgical Procedures, Operative / Q000379:methods / Q000592:standards*; D015996:Survival Rate; D016896:Treatment Outcome
keywords: extended compartment resection; leiomyosarcoma; liposarcoma; retroperitoneal sarcoma