title: A CMOS sensor for rapid testing of pathogen susceptibility to pore-forming antibiotics.
abstract: An integrated CMOS chip is implemented in 0.13μm technology that detects the efficacy of pore-forming antibiotics on bacterial samples in 10 minutes. The chip has been tested using two strains of E. coli and polymyxin B as the model antibiotic. An array of potassium-sensitive ISFETs and their readout circuits are integrated on the CMOS chip and a potassium-sensitive membrane is directly attached to the top metal electrodes, to measure potassium efflux from the affected bacterial cells.
authors.forename: Nasim
authors.initials: N
authors.lastname: Nikkhoo
authors.forename: P Glenn
authors.initials: PG
authors.lastname: Gulak
authors.forename: Karen
authors.initials: K
authors.lastname: Maxwell
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D056656:Lab-On-A-Chip Devices; D008826:Microbial Sensitivity Tests / Q000295:instrumentation; D011112:Polymyxin B / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D011112:Polymyxin B; D011188:Potassium