title: Biological processes in solar lentigo: insights brought by experimental models.
abstract: Common in ageing patient, the solar lentigo is a macular hyperpigmented skin lesion that results from chronic exposure to ultraviolet irradiations. Despite sharing numerous features with other pigmented spots, the diagnostic of this benign lesion is well characterized at the tissue level. Recent studies shed lights on several factors and their pathogenic mechanisms involved in the development of the solar lentigo. This review summarizes how diverse experimental approaches allowed the identification of several biomarkers, which contribute to a better understanding on the initiation and the maintenance of this pigmentary disorder.
authors.affiliation: LIBC, Engineering and Cutaneous Biology Laboratory, UMR 1098 INSERM, University of Franche-Comte, SFR FED 4234, Besançon, France.|UMR 978 INSERM, Bobigny Cedex, France.|ASIH, Signaling Adaptors in Hematology, UFR-SMBH, Labex INFLAMEX, University SPC, Paris 13, Bobigny Cedex, France.|Department of Dermatology, Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC 1431), Besançon University Hospital, Besançon, France.|Dermance Laboratoire, Dermo-cosmetic and Mature Skin Expertise, Paris, France.
authors.forename: Ranesha
authors.initials: R
authors.lastname: Goorochurn
authors.affiliation: LIBC, Engineering and Cutaneous Biology Laboratory, UMR 1098 INSERM, University of Franche-Comte, SFR FED 4234, Besançon, France.
authors.forename: Cécline
authors.initials: C
authors.lastname: Viennet
authors.affiliation: Dermance Laboratoire, Dermo-cosmetic and Mature Skin Expertise, Paris, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Granger
authors.affiliation: Department of Dermatology, Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC 1431), Besançon University Hospital, Besançon, France.
authors.forename: Ferial
authors.initials: F
authors.lastname: Fanian
authors.affiliation: UMR 978 INSERM, Bobigny Cedex, France.|ASIH, Signaling Adaptors in Hematology, UFR-SMBH, Labex INFLAMEX, University SPC, Paris 13, Bobigny Cedex, France.
authors.forename: Nadine
authors.initials: N
authors.lastname: Varin-Blank
authors.affiliation: UMR 978 INSERM, Bobigny Cedex, France.|ASIH, Signaling Adaptors in Hematology, UFR-SMBH, Labex INFLAMEX, University SPC, Paris 13, Bobigny Cedex, France.
authors.forename: Christine Le
authors.initials: CL
authors.lastname: Roy
authors.affiliation: LIBC, Engineering and Cutaneous Biology Laboratory, UMR 1098 INSERM, University of Franche-Comte, SFR FED 4234, Besançon, France.|Department of Dermatology, Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC 1431), Besançon University Hospital, Besançon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Humbert
mesh_terms: D000368:Aged; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy / Q000379:methods; D003880:Dermatology / Q000379:methods; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D015603:Keratinocytes / Q000166:cytology; D007911:Lentigo / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy*; D051379:Mice; D010859:Pigmentation Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D015595:Skin Aging; D013472:Sunlight / Q000009:adverse effects; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D015415:Biomarkers
keywords: biomarkers; experimental models; hyperpigmentation disorders; solar lentigo