title: Notch signalling in the nucleus: roles of Mastermind-like (MAML) transcriptional coactivators.
abstract: Notch signalling plays pivotal roles in development and homeostasis of all metazoan species. Notch is a receptor molecule that directly translates information of cell-cell contact to gene expression in the nucleus. Mastermind is a conserved and essential nuclear factor that supports the activity of Notch. Here, the past and current studies of the interplay between these factors are reviewed.
authors.affiliation: Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-Ku, Chiba 260-8670, Japan kitagawa@faculty.chiba-u.jp.
authors.forename: Motoo
authors.initials: M
authors.lastname: Kitagawa
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C430872:MAML1 protein, human; C471297:MAML2 protein, human; C471298:MAML3 protein, human; C467910:MAML3 protein, mouse; C495418:MECT1-MAML2 fusion protein, human; C486455:Maml1 protein, mouse; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; D051880:Receptors, Notch; D015534:Trans-Activators; D014157:Transcription Factors; C085316:mam protein, Drosophila
keywords: MAML; Mastermind; Notch signalling; signal transduction; transcription