title: Fluvastatin Decreases Oxidative Stress in Kidney Transplant Patients.
abstract: OBJECTIVE
  Oxidative stress has been suggested to have a pivotal role in the development of cardiovascular disease in kidney transplant patients (KTPs). The effects of fluvastatin on oxidative status in KTPs have not been well evaluated. The aim of the present study was to evaluate the effects of fluvastatin on oxidative status by investigating erythrocyte superoxide dismutase (SOD), erythrocyte glutathione peroxidase (GPx), serum paraoxonase (PON1), and serum arylesterase (ARE), along with lipid peroxidation products, serum malonldialdehyde, and apolipoprotein B malondialdehyde (ApoB MDA).
  
  
  METHODS
  Eighteen KTPs were included in the present study. Blood samples were obtained after 1 night's fast. Erythrocyte SOD, erythrocyte GPx, serum PON1, serum ARE, serum MDA, and ApoB MDA were measured using methods described previously. Paired-sample t test was used for comparing the changes from week 0 to week 4 of parameters that might be associated with fluvastatin treatment.
  
  
  RESULTS
  The present study has shown that erythrocyte SOD and GPx, and serum PON1 and ARE activities increased at the fourth week of the statin treatment. Furthermore an increase in the antioxidant enzymes following fluvastatin may be a clue for the antioxidant effects of this drug. Four weeks of fluvastatin long-acting tablets 80 mg/day led to a decrease in plasma Apo-MDA and MDA levels.
  
  
  CONCLUSIONS
  The findings of the present study demonstrate that fluvastatin 80 mg long-acting tablets may be used safely for 4 weeks and decrease atherogenic lipoproteins in KTPs. Furthermore, after 4 weeks of fluvastatin treatment, the levels of antioxidant parameters increased and oxidative parameters decreased. Further placebo-controlled treatment studies would be helpful to evaluate the effects of fluvastatin on oxidant and antioxidant parameters including PON1 in patients with KT.
authors.affiliation: Department of Nephrology, Uludag University Medical School, Bursa, Turkey. Electronic address: mecityildiz@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Yildiz
authors.affiliation: Department of Nephrology, Bursa Sevket Yilmaz Training and Research Hospital, Bursa, Turkey.
authors.forename: C B
authors.initials: CB
authors.lastname: Gul
authors.affiliation: Department of Biochemistry, Uludag University Medical School, Bursa, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Ocak
authors.affiliation: Department of Nephrology, Uludag University Medical School, Bursa, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Ersoy
authors.affiliation: Department of Cardiology, Uludag University Medical School, Bursa, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Sag
authors.affiliation: Department of Nephrology, Uludag University Medical School, Bursa, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Oruc
authors.affiliation: Department of Nephrology, Uludag University Medical School, Bursa, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Ayar
authors.affiliation: Department of Nephrology, Bursa Sevket Yilmaz Training and Research Hospital, Bursa, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Dagel
authors.affiliation: Department of Biochemistry, Uludag University Medical School, Bursa, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Dirican
authors.affiliation: Department of Nephrology, Uludag University Medical School, Bursa, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Gullulu
mesh_terms: D000328:Adult; D001055:Apolipoproteins B / Q000097:blood; D043303:Aryldialkylphosphatase / Q000097:blood; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated / Q000627:therapeutic use*; D005260:Female; D000077340:Fluvastatin; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007211:Indoles / Q000627:therapeutic use*; D016030:Kidney Transplantation; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000097:blood; D066027:Transplant Recipients
chemical_list: D001055:Apolipoproteins B; D005229:Fatty Acids, Monounsaturated; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D000077340:Fluvastatin; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase