title: Peripapillary Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Thickness in Children with Familial Mediterranean Fever.
abstract: OBJECTIVE
  To evaluate the thickness of the peripapillary retinal nerve fiber layer (RNFL) and retinal ganglion cell-inner plexiform layer (GCIPL) in children with familial Mediterranean fever (FMF).
  
  
  METHODS
  The study included 39 FMF patients and 36 healthy controls. After detailed ocular examination, the thickness of the peripapillary RNFL and GCIPL were measured by spectral domain optic coherence tomography (SD-OCT). All measurements were taken from the right eye of the patients and controls. According to their disease severity score (DSS), the patients were divided into two groups: patients with DSS ≤5 and those with DSS >5.
  
  
  RESULTS
  There were no statistically significant differences in peripapillary RNFL and retinal GCIPL thickness between patients with FMF and controls.
  
  
  CONCLUSIONS
  It appears that FMF does not affect the RNFL and GCIPL thickness.
authors.affiliation: a Department of Ophthalmology , Gaziosmanpaşa University Faculty of Medicine , Tokat , Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Alim
authors.affiliation: b Department of Pediatrics , Gaziosmanpaşa University Faculty of Medicine , Tokat , Turkey.
authors.forename: Samet
authors.initials: S
authors.lastname: Özer
authors.affiliation: a Department of Ophthalmology , Gaziosmanpaşa University Faculty of Medicine , Tokat , Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Demir
authors.affiliation: a Department of Ophthalmology , Gaziosmanpaşa University Faculty of Medicine , Tokat , Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Ortak
authors.affiliation: b Department of Pediatrics , Gaziosmanpaşa University Faculty of Medicine , Tokat , Turkey.
authors.forename: Ergün
authors.initials: E
authors.lastname: Sönmezgöz
authors.affiliation: c Department of Ophthalmology , Niksar State Hospital , Tokat , Turkey.
authors.forename: Ergün
authors.initials: E
authors.lastname: Er
authors.affiliation: d Department of Biostatistics , Tokat , Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Demir
mesh_terms: D002648:Child; D010505:Familial Mediterranean Fever / Q000150:complications*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity
keywords: Childhood disease; disease severity score; familial Mediterranean fever; ganglion cell inner plexiform layer; retinal nerve fiber layer