title: A naphthalimide derived fluorescent sensor for solid-phase screening of cucurbit[7]uril-guest interactions.
abstract: A naphthalimide based fluorescent sensor displaying a significant increase in emission upon binding CB[7] with notable pH stability was developed and utilized in a surface-bound displacement assay for the rapid detection of CB[7] encapsulation of therapeutically relevant drug classes. Previously unknown binders with moderate to strong affinities were discovered.
authors.affiliation: Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, Louisiana, USA. jananj@tulane.edu.
authors.forename: Gyan Hari
authors.initials: GH
authors.lastname: Aryal
authors.affiliation: Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, Louisiana, USA. jananj@tulane.edu.
authors.forename: Cooper Hawkins
authors.initials: CH
authors.lastname: Battle
authors.affiliation: Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, Louisiana, USA. jananj@tulane.edu.
authors.forename: Tod A
authors.initials: TA
authors.lastname: Grusenmeyer
authors.affiliation: Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, Louisiana, USA. jananj@tulane.edu.
authors.forename: Mengyuan
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, Louisiana, USA. jananj@tulane.edu.
authors.forename: Janarthanan
authors.initials: J
authors.lastname: Jayawickramarajah
mesh_terms: D001952:Bridged-Ring Compounds / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D053644:Naphthalimides / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D001952:Bridged-Ring Compounds; D005456:Fluorescent Dyes; D007093:Imidazoles; D053644:Naphthalimides; C456276:cucurbit(7)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils