title: Auditory evoked potentials in a newborn Wistar rat model of hyperbilirubinemia.
abstract: BACKGROUND
  Hyperbilirubinemia is a common health problem in newborns. Its effects can be different according to the level and duration of the hyperbilirubinemia. The toxic effect of bilirubin on the auditory system can be seen as a sensory neural hearing loss or auditory neuropathy spectrum disorder (ANSD).
  
  
  OBJECTIVE
  The purpose of our study was to determine the effects of toxic bilirubin level on the auditory system by using Auditory Brainstem Response audiometry.
  
  
  METHODS
  Rats are used as animal models due to their low cost and easy attainability. Auditory Brainstem Response was used for auditory assessment. In this study, three groups were established: experimental, control and placebo groups.
  
  
  RESULTS
  In the experimental group, which consists of rats with hyperbilirubinemia, sensory neural hearing loss was found bilaterally in 4 rats (66.67%) and unilaterally in 2 rats (16.67%) and auditory neuropathy spectrum disorder was found unilaterally in 1 rat (8.33%). Auditory Brainstem Response thresholds were significantly elevated compared to control and placebo groups (p<0.05).
  
  
  CONCLUSIONS
  Hyperbilirubinemia of newborn rats may result both in sensory neural hearing loss and auditory neuropathy spectrum disorder.
authors.affiliation: Gazi University Hospital, Audiology Department, Ankara, Turkey. Electronic address: cagilgokdogan@gmail.com.
authors.forename: Çağıl
authors.initials: Ç
authors.lastname: Gökdoğan
authors.affiliation: Hacettepe University Hospital, Audiology Department, Ankara, Turkey.
authors.forename: Aydan
authors.initials: A
authors.lastname: Genç
authors.affiliation: Gazi University Hospital, Biochemistry Department, Ankara, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Gülbahar
authors.affiliation: Memorial Hospital, ENT Department, Ankara, Turkey.
authors.forename: Ozan
authors.initials: O
authors.lastname: Gökdoğan
authors.affiliation: Gazi University Hospital, Pathology Department, Ankara, Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Helvacı
authors.affiliation: Gazi University Hospital, ENT Department, Ankara, Turkey.
authors.forename: Selin Üstün
authors.initials: SÜ
authors.lastname: Bezgin
authors.affiliation: Gazi University Hospital, Pathology Department, Ankara, Turkey.
authors.forename: Leyla
authors.initials: L
authors.lastname: Memiş
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001299:Audiometry; D004195:Disease Models, Animal; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D006319:Hearing Loss, Sensorineural / Q000209:etiology / Q000503:physiopathology*; D051556:Hyperbilirubinemia, Neonatal / Q000150:complications / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
keywords: Auditory evoked potentials; Deficiência auditiva neurosensorial; Hiperbilirrubinemia; Hyperbilirubinemia; Potenciais evocados auditivos; Ratos Wistar; Sensorineural hearing loss; Wistar rats