title: Effect of functionalization on drug delivery potential of carbon nanotubes.
abstract: The main aim of the present investigation was to explore the effect of functionalization on drug delivery potential of carbon nanotubes (CNTs) and to compare the in vitro and in vivo cancer targeting potential of doxorubicin HCL (DOX)-loaded ox-/multi-walled CNTs (MWCNTs), DOX-loaded PEG-MWCNTs and DOX-loaded FA-PEG-MWCNTs. The DOX/PEG-FA-MWCNTs showed enhanced cytotoxicity and were most preferentially taken up by the cancerous cells. The obtained results also support the extended resistance time and sustained release profile of drug-loaded surface-engineered MWCNTs. Overall, we concluded that the developed MWCNTs nanoformulations have higher cancer targeting potential.
authors.affiliation: a Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences , I.S.F. College of Pharmacy , Moga , India.
authors.forename: Sonam
authors.initials: S
authors.lastname: Sharma
authors.affiliation: a Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences , I.S.F. College of Pharmacy , Moga , India.
authors.forename: Neelesh Kumar
authors.initials: NK
authors.lastname: Mehra
authors.affiliation: a Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences , I.S.F. College of Pharmacy , Moga , India.
authors.forename: Keerti
authors.initials: K
authors.lastname: Jain
authors.affiliation: a Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences , I.S.F. College of Pharmacy , Moga , India.
authors.forename: Narendra Kumar
authors.initials: NK
authors.lastname: Jain
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004317:Doxorubicin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D037742:Nanotubes, Carbon / Q000737:chemistry*
chemical_list: D037742:Nanotubes, Carbon; D004317:Doxorubicin
keywords: carbon nanotubes; cellular trafficking; characterization; functionalization