title: Layer-by-layer assembly of copper nanoparticles and manganese dioxide-multiwalled carbon nanotubes film: A new nonenzymatic electrochemical sensor for glucose.
abstract: A nonenzymatic glucose sensor based on Cu/MnO2/MWCNTs nanocomposite modified glass carbon electrode was fabricated by an electrochemical method. Transmission electron microscopic (TEM) measurement showed that MnO2 in the nanocomposite held a nanostructure of three-dimension (3D) spheres assembled by many densely arranged nanosheets. The electrocatalytic activity of the present sensor toward the oxidation of glucose was investigated by amperometry. The current response was linearly related to glucose concentration in a range from 6.4×10(-7)-2.0×10(-3)molL(-1) with a sensitivity of 494μA mM(-1)cm(-2) and a correlation coefficient of 0.9990, and another range from 10 to 1000μM with a sensitivity of 1302μA mM(-1)cm(-2) and a correlation coefficient of 0.9990. The detection limit was estimated to be 0.17μM at a signal-to-noise ratio of 3, and the response time was found to be 3s.
authors.affiliation: Institute of Analytical Science, Shaanxi Provincial Key Laboratory of Electroanalytical Chemistry, Northwest University, Xi'an, Shaanxi 710069, China; College of Pharmacy, Xi'an Medical University, Xi'an, Shaanxi 710021, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Analytical Science, Shaanxi Provincial Key Laboratory of Electroanalytical Chemistry, Northwest University, Xi'an, Shaanxi 710069, China.
authors.forename: Sai
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Institute of Analytical Science, Shaanxi Provincial Key Laboratory of Electroanalytical Chemistry, Northwest University, Xi'an, Shaanxi 710069, China.
authors.forename: Wushuang
authors.initials: W
authors.lastname: Bai
authors.affiliation: Institute of Analytical Science, Shaanxi Provincial Key Laboratory of Electroanalytical Chemistry, Northwest University, Xi'an, Shaanxi 710069, China. Electronic address: zhengjb@nwu.edu.cn.
authors.forename: Jianbin
authors.initials: J
authors.lastname: Zheng
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D003300:Copper / Q000737:chemistry*; D055664:Electrochemical Techniques; D005947:Glucose / Q000032:analysis* / Q000737:chemistry; D006801:Humans; D017895:Manganese Compounds / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D017895:Manganese Compounds; D037742:Nanotubes, Carbon; D010087:Oxides; D003300:Copper; D005947:Glucose; C016552:manganese dioxide
keywords: Copper; Glucose; MWCNTs; Manganese dioxide; Nonenzymatic sensor