title: Microbial production of value-added nutraceuticals.
abstract: Nutraceuticals are important natural bioactive compounds that confer health-promoting and medical benefits to humans. Globally growing demands for value-added nutraceuticals for prevention and treatment of human diseases have rendered nutraceuticals a multi-billion dollar market. However, supply limitations and extraction difficulties from natural sources such as plants, animals or fungi, restrict the large-scale use of nutraceuticals. Metabolic engineering via microbial production platforms has been advanced as an eco-friendly alternative approach for production of value-added nutraceuticals from simple carbon sources. Microbial platforms like the most widely used Escherichia coli and Saccharomyces cerevisiae have been engineered as versatile cell factories for production of diverse and complex value-added chemicals such as phytochemicals, prebiotics, polysaccaharides and poly amino acids. This review highlights the recent progresses in biological production of value-added nutraceuticals via metabolic engineering approaches.
authors.affiliation: College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Division of Biochemistry, Sher-e-Kashmir University of Agricultural Sciences and Technology, Main Campus Chatha-180009, Jammu, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Guleria
authors.affiliation: Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies (CBIS), Rensselaer Polytechnic Institute, 110 8(th) Street, Troy, NY 12180, United States; Department of Biology, Center for Biotechnology and Interdisciplinary Studies (CBIS), Rensselaer Polytechnic Institute, 110 8(th) Street, Troy, NY 12180, United States. Electronic address: koffam@rpi.edu.
authors.forename: Mattheos Ag
authors.initials: MA
authors.lastname: Koffas
authors.affiliation: BioChemical Engineering Program, College of Engineering, University of Georgia, Athens, Georgia 30602, United States. Electronic address: yajunyan@uga.edu.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Yan
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001688:Biological Products / Q000378:metabolism*; D019587:Dietary Supplements; D004926:Escherichia coli / Q000378:metabolism; D006801:Humans; D060847:Metabolic Engineering; D012441:Saccharomyces cerevisiae / Q000378:metabolism
chemical_list: D000596:Amino Acids; D001688:Biological Products