title: Selected Noninvasive Markers in Diagnosing Liver Diseases.
abstract: OBJECTIVE
  To evaluate the effectiveness of certain noninvasive liver-damage markers in predicting liver diseases and the clinical severity of liver cirrhosis.
  
  
  METHODS
  We tested serum specimens from 57 patients with alcoholic cirrhosis, 30 with nonalcoholic cirrhosis, and 22 with toxic hepatitis (TH). The Bonacini, King, and Göteborg University Cirrhosis Index (GUCI) scores were calculated using specific formulas.
  
  
  RESULTS
  The values of the Bonacini and King scores significantly differ between liver diseases. The Bonacini score was higher in alcoholic and nonalcoholic cirrhosis than in TH, and the King score was higher in alcoholic cirrhosis than in TH. All of the tested scores appeared to vary according to the severity of liver damage and were higher in Child-Pugh class C than that in classes A and B.
  
  
  CONCLUSIONS
  We conclude that the Bonacini and King scores differ between liver diseases and that all the tested scores reflect the severity of liver cirrhosis.
authors.affiliation: Department of Biochemical Diagnostics.
authors.forename: Monika
authors.initials: M
authors.lastname: Gudowska
authors.affiliation: Department of Biochemical Diagnostics.
authors.forename: Ewa
authors.initials: E
authors.lastname: Gruszewska
authors.affiliation: Departments of Infectious Diseases and Hepatology, and.
authors.forename: Anatol
authors.initials: A
authors.lastname: Panasiuk
authors.affiliation: Department of Pediatric Laboratory Diagnostics, Medical University of Bialystok, Poland.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Cylwik
authors.affiliation: Departments of Infectious Diseases and Hepatology, and.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Świderska
authors.affiliation: Departments of Infectious Diseases and Hepatology, and.
authors.forename: Robert
authors.initials: R
authors.lastname: Flisiak
authors.affiliation: Department of Biochemical Diagnostics.
authors.forename: Maciej
authors.initials: M
authors.lastname: Szmitkowski
authors.affiliation: Department of Biochemical Diagnostics, chrostek@umb.edu.pl.
authors.forename: Lech
authors.initials: L
authors.lastname: Chrostek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D003955:Diagnostic Tests, Routine / Q000379:methods*; D005260:Female; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis*; D044967:Serum / Q000737:chemistry; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: liver cirrhosis; liver fibrosis; noninvasive markers; serum markers; toxic hepatitis