title: Is there association between vitamin D levels, apelin 36, and visfatin in PCOS?
abstract: OBJECTIVE
  We aimed to evaluate vitamin D, apelin-36, and visfatin levels in patients with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  The study was completed in six months, including a total of 110 patients who were admitted to the obstetrics and gynecology polyclinic. Patients with a diagnosis of PCOS were divided into two subgroups according to their vitamin D levels. Thirty-four patients had <10 ng/ml of vitamin D deficiency and 21 patients had 10-30 ng/ml of vitamin D insufficiency, with each being defined as a subgroup.
  
  
  RESULTS
  Average apelin-36 and visfatin levels in PCOS patients were 2.52 ± 0.68 nmol/L and 72.63 ± 22:31 ng/ml, in the control group they were 0.92 ± 0.33 nmol/L, 24.66 ± 6 ng/ml, respectively. The difference found in PCOS patients was statistically significant (p = 0.0001, p = 0.0001).
  
  
  CONCLUSIONS
  In conclusion, the present study shows that in PCOS patients with low levels of vitamin D, insulin resistance is greater and apelin-36 serum levels were significantly higher. Although there are different opinions in the literature on this subject, we believe that when vitamin D levels are brought to an optimal level in PCOS patient, it can prevent the negative effects of adipokines in the pathogenesis of PCOS.
authors.affiliation: a Department of Obstetrics and Gynaecology , Faculty of Medicine, Bozok University , Yozgat , Turkey and.
authors.forename: Emel
authors.initials: E
authors.lastname: Kiyak Caglayan
authors.affiliation: a Department of Obstetrics and Gynaecology , Faculty of Medicine, Bozok University , Yozgat , Turkey and.
authors.forename: Yaprak
authors.initials: Y
authors.lastname: Engin-Üstun
authors.affiliation: a Department of Obstetrics and Gynaecology , Faculty of Medicine, Bozok University , Yozgat , Turkey and.
authors.forename: Nagihan
authors.initials: N
authors.lastname: Sari
authors.affiliation: b Department of Biochemistry , Bozok University Faculty of Medicine , Yozgat , Turkey.
authors.forename: Ayşe Yesim
authors.initials: AY
authors.lastname: Göçmen
authors.affiliation: a Department of Obstetrics and Gynaecology , Faculty of Medicine, Bozok University , Yozgat , Turkey and.
authors.forename: Levent
authors.initials: L
authors.lastname: Seckin
authors.affiliation: a Department of Obstetrics and Gynaecology , Faculty of Medicine, Bozok University , Yozgat , Turkey and.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kara
authors.affiliation: b Department of Biochemistry , Bozok University Faculty of Medicine , Yozgat , Turkey.
authors.forename: Asli
authors.initials: A
authors.lastname: Metin
authors.affiliation: b Department of Biochemistry , Bozok University Faculty of Medicine , Yozgat , Turkey.
authors.forename: M Fevzi
authors.initials: MF
authors.lastname: Polat
mesh_terms: D054392:Adipokines / Q000097:blood; D000328:Adult; D000073861:Apelin; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008055:Lipids / Q000097:blood; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D014807:Vitamin D / Q000097:blood*; D055815:Young Adult
chemical_list: C115436:APLN protein, human; D054392:Adipokines; D000073861:Apelin; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D008055:Lipids; D014807:Vitamin D; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human
keywords: Insulin resistance; ovary; polycystic ovary syndrome