title: Self-referenced, microdegree, optical rotation polarimeter for biomedical applications: an analysis.
abstract: We comprehensively analyze the performance of a type of optical rotation (OR) polarimeter, which has been designed from the outset to fit the special requirements of two major applications: general chiral detection during the separation of optical isomers by high-pressure liquid chromatography systems in the pharmaceutical industry, and monitoring of glucose in the interstitial fluid of diabetics by a fully implanted long-term optical sensor. Both very demanding applications call for an OR polarimeter that can be miniaturized while maintaining high resolution and accuracy in the microdegree range in the face of considerable noise from various sources. These two characteristics—miniature size and immunity to noise—set this polarimeter apart from the traditional OR polarimeters currently in use, which are both bulky and very susceptible to noise. The following detailed analysis demonstrates the advantages of this polarimeter and its potential as an analytic and diagnostic tool.
authors.affiliation: Shenkar College of Engineering and Design, Electrical Engineering Department, 12 Anne Frank Street, Ramat Gan 52526, Israel.
authors.forename: Zeev
authors.initials: Z
authors.lastname: Weissman
authors.affiliation: MIGAL Galilee Research Institute, Medical and Diagnostic Instruments Development, Southern Industrial Zone, Tarshish Street 1, Kiryat Shmona 11016, IsraelcTel Hai College, Faculty of Science and Technology, Upper Galilee, Kiryat Shmona 12209, Israel.
authors.forename: Doron
authors.initials: D
authors.lastname: Goldberg
mesh_terms: D004867:Equipment Design; D005947:Glucose / Q000032:analysis / Q000737:chemistry; D016014:Linear Models; D009904:Optical Rotation; D055095:Optics and Photonics / Q000295:instrumentation* / Q000379:methods*
chemical_list: D005947:Glucose