title: Evaluation of a pre-surgical functional MRI workflow: From data acquisition to reporting.
abstract: OBJECTIVE
  Present and assess clinical protocols and associated automated workflow for pre-surgical functional magnetic resonance imaging in brain tumor patients.
  
  
  METHODS
  Protocols were validated using a single-subject reliability approach based on 10 healthy control subjects. Results from the automated workflow were evaluated in 9 patients with brain tumors, comparing fMRI results to direct electrical stimulation (DES) of the cortex.
  
  
  RESULTS
  Using a new approach to compute single-subject fMRI reliability in controls, we show that not all tasks are suitable in the clinical context, even if they show meaningful results at the group level. Comparison of the fMRI results from patients to DES showed good correspondence between techniques (odds ratio 36).
  
  
  CONCLUSIONS
  Providing that validated and reliable fMRI protocols are used, fMRI can accurately delineate eloquent areas, thus providing an aid to medical decision regarding brain tumor surgery.
authors.affiliation: Brain Research Imaging Centre, The University of Edinburgh, UK; Centre for Clinical Brain Sciences, The University of Edinburgh, UK. Electronic address: cyril.pernet@ed.ac.uk.
authors.forename: Cyril R
authors.initials: CR
authors.lastname: Pernet
authors.affiliation: Department of Psychology, Stanford University, Stanford, USA.
authors.forename: Krzysztof J
authors.initials: KJ
authors.lastname: Gorgolewski
authors.affiliation: Brain Research Imaging Centre, The University of Edinburgh, UK; Centre for Clinical Brain Sciences, The University of Edinburgh, UK.
authors.forename: Dominic
authors.initials: D
authors.lastname: Job
authors.affiliation: Brain Research Imaging Centre, The University of Edinburgh, UK; Centre for Clinical Brain Sciences, The University of Edinburgh, UK.
authors.forename: David
authors.initials: D
authors.lastname: Rodriguez
authors.affiliation: School of Informatics, The University of Edinburgh, UK.
authors.forename: Amos
authors.initials: A
authors.lastname: Storkey
authors.affiliation: Brain Research Imaging Centre, The University of Edinburgh, UK; Division of Clinical Neuroscience, NHS-Lothian, Edinburgh, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Whittle
authors.affiliation: Brain Research Imaging Centre, The University of Edinburgh, UK; Centre for Clinical Brain Sciences, The University of Edinburgh, UK.
authors.forename: Joanna
authors.initials: J
authors.lastname: Wardlaw
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods*; D001932:Brain Neoplasms / Q000503:physiopathology* / Q000601:surgery; D016022:Case-Control Studies; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D057188:Workflow
keywords: Brain tumors; Functional MRI; Protocol; Surgical planning; Workflow