title: Influence of End-Stage Renal Disease on Hematoma Volume and Intraventricular Hemorrhage in Patients with Intracerebral Hemorrhage: A Cohort Study and Meta-Analysis.
abstract: OBJECTIVE
  To assess the association between end-stage renal disease (ESRD) and hematoma volume and intraventricular hemorrhage (IVH), we performed a meta-analysis of all available evidence, including data from our own center.
  
  
  METHODS
  We reviewed major literature databases to identify studies on association between ESRD and hematoma volume and IVH, and the association between ESRD and hematoma site. We then combined these data with those from our own retrospective cohort study. The relationship between ESRD and functional outcome was analyzed using logistic regression.
  
  
  RESULTS
  Our retrospective study involved 15 patients with ESRD of 302 subjects. The results showed that patients with ESRD had larger hematoma volume (p = 0.028), higher proportion of patients with hematoma volume over 30 ml (OR 3.89, 95% CI 1.20-12.56 in model 1 and OR 3.72, 95% CI 1.15-12.06 in model 3), and higher incidence of IVH (OR 3.45, 95% CI 1.14-10.46 in model 1 and OR 3.22, 95% CI 1.07-9.66 in model 2) than patients without ESRD. The meta-analysis further supported a relationship between the risk of ESRD and hematoma volume (p = 0.014), as well as IVH (OR 2.82, 95% CI 2.03-3.91). On multivariate analysis, ESRD was significantly associated with the mortality at the third month (OR 7.534, 95% CI 1.495-38.491).
  
  
  CONCLUSIONS
  Evidence strongly suggests that ESRD is independently associated with hematoma volume and IVH, and is an independent risk factor for mortality at the third month.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, PR China.
authors.forename: Mangmang
authors.initials: M
authors.lastname: Xu
authors.forename: Chunyan
authors.initials: C
authors.lastname: Lei
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Junfeng
authors.initials: J
authors.lastname: Liu
authors.forename: Ge
authors.initials: G
authors.lastname: Tan
authors.forename: Dan
authors.initials: D
authors.lastname: Li
mesh_terms: D000368:Aged; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000473:pathology*; D015331:Cohort Studies; D006406:Hematoma / Q000209:etiology / Q000473:pathology; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000150:complications*; D016015:Logistic Models; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors