title: Medial temporal lobe high resolution magnetic resonance images for the early diagnosis of Alzheimer's disease.
abstract: A challenging point in neuroimaging is the diagnosis of Alzheimer's disease (AD) during its asymptomatic phase. Among all the biomarkers proposed in the literature, a measure of the hippocampal atrophy via Magnetic Resonance Imaging (MRI) seems to be one of the most reliable. Refined image processing techniques were already proposed to automatically extract the hippocampal boxes from images acquired with the standard full brain acquisition protocol suggested by the Alzheimer's Disease Neuroimaging Initiative (ADNI). In order to enhance this approach, here we propose a high resolution (HR) MRI protocol focused on the medial temporal lobe (MTL) mainly conceived for 1.5T MRI device, hereafter referred as MTL-HR protocol. A preliminary characterization of its behavior when compared to the standard ADNI protocol is also presented.
authors.forename: Francesco
authors.initials: F
authors.lastname: Brun
authors.forename: Francesco
authors.initials: F
authors.lastname: Sensi
authors.forename: Rossella
authors.initials: R
authors.lastname: Quartulli
authors.forename: Luca
authors.initials: L
authors.lastname: Rei
authors.forename: Alban
authors.initials: A
authors.lastname: Grucka
authors.forename: Valentina
authors.initials: V
authors.lastname: Mancarella
authors.forename: Andrea
authors.initials: A
authors.lastname: Chincarini
authors.forename: Maja
authors.initials: M
authors.lastname: Ukmar
authors.forename: Agostino
authors.initials: A
authors.lastname: Accardo
authors.forename: Renata
authors.initials: R
authors.lastname: Longo
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D001284:Atrophy; D042241:Early Diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D013702:Temporal Lobe