title: A proof-of-concept study for predicting the region of atherosclerotic plaque development based on plaque growth modeling in carotid arteries.
abstract: In this work, we present a computational model for plaque growth utilizing magnetic resonance data of a patient's carotid artery. More specifically, we model blood flow utilizing the Navier-Stokes equations, as well as LDL and HDL transport using the convection-diffusion equation in the arterial lumen. The accumulated LDL in the arterial wall is oxidized considering the protective effect of HDL. Macrophages recruitment and foam cells formation are the final step of the proposed multi-level modeling approach of the plaque growth. The simulated results of our model are compared with the follow-up MRI findings in 12 months regarding the change to the arterial wall thickness. WSS and LDL may indicate potential regions of plaque growth (R(2)=0.35), but the contribution of foam cells formation, macrophages and oxidized LDL increased the prediction significantly (R(2)=0.75).
authors.forename: Antonis I
authors.initials: AI
authors.lastname: Sakellarios
authors.forename: Paschalis
authors.initials: P
authors.lastname: Bizopoulos
authors.forename: Kostas
authors.initials: K
authors.lastname: Stefanou
authors.forename: Lambros S
authors.initials: LS
authors.lastname: Athanasiou
authors.forename: Michail I
authors.initials: MI
authors.lastname: Papafaklis
authors.forename: Christos V
authors.initials: CV
authors.lastname: Bourantas
authors.forename: Katerina K
authors.initials: KK
authors.lastname: Naka
authors.forename: Lampros K
authors.initials: LK
authors.lastname: Michalis
authors.forename: Dimitrios I
authors.initials: DI
authors.lastname: Fotiadis
mesh_terms: D002339:Carotid Arteries / Q000473:pathology / Q000503:physiopathology; D003198:Computer Simulation; D006801:Humans; D008955:Models, Cardiovascular; D058226:Plaque, Atherosclerotic / Q000473:pathology / Q000503:physiopathology