title: Intrathecal synthesis of onconeural antibodies in patients with paraneoplastic syndromes.
abstract: Paraneoplastic neurological syndromes (PNSs) are a group of immune-mediated neurological disorders occurring in patients with systemic cancers which are associated with the presence of anti-neuronal antibodies. In this retrospective study, serum and cerebrospinal fluid of 489 patients were analyzed for the presence of well characterized onconeural antibodies. The 18 PNS patients positive for onconeural antibodies were reanalyzed to evaluate possible intrathecal synthesis. Intrathecal synthesis of onconeural antibodies, was detected in 10/15 patients affected by PNSs involving the CNS and in 1/3 cases with peripheral syndromes. Our data confirm that onconeural antibodies are produced within the CNS in most PNS patients. Evaluation of intrathecal synthesis of onconeural antibodies on a larger cohort of PNS patients and the correlation with disease course might elucidate whether this marker has a value in predicting the prognosis of the neurological disease.
authors.affiliation: Laboratory of Clinical Pathology and Medical Genetics, Foundation IRCCS Neurological Institute C. Besta, Via Celoria, 11, 20133 Milan, Italy. Electronic address: corsini.e@istituto-besta.it.
authors.forename: Elena
authors.initials: E
authors.lastname: Corsini
authors.affiliation: Unit of Neurooncology, Department of Clinical Neurosciences, Foundation IRCCS Neurological Institute C. Besta, Via Celoria, 11, 20133 Milan, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Gaviani
authors.affiliation: Neuroradiology Department, Foundation IRCCS Neurological Institute C. Besta, Via Celoria, 11, 20133 Milan, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Chiapparini
authors.affiliation: Laboratory of Clinical Pathology and Medical Genetics, Foundation IRCCS Neurological Institute C. Besta, Via Celoria, 11, 20133 Milan, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Lazzaroni
authors.affiliation: Laboratory of Clinical Pathology and Medical Genetics, Foundation IRCCS Neurological Institute C. Besta, Via Celoria, 11, 20133 Milan, Italy.
authors.forename: Emilio
authors.initials: E
authors.lastname: Ciusani
authors.affiliation: Neuroradiology Department, Foundation IRCCS Neurological Institute C. Besta, Via Celoria, 11, 20133 Milan, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Bisogno
authors.affiliation: Unit of Neurooncology, Department of Clinical Neurosciences, Foundation IRCCS Neurological Institute C. Besta, Via Celoria, 11, 20133 Milan, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Silvani
authors.affiliation: Neurological Department, A. Manzoni Hospital, Via dell'Eremo 9/11, 23900 Lecco, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Salmaggi
authors.affiliation: Laboratory of Clinical Pathology and Medical Genetics, Foundation IRCCS Neurological Institute C. Besta, Via Celoria, 11, 20133 Milan, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Bernardi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000912:Antibodies, Neoplasm / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid* / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020361:Paraneoplastic Syndromes, Nervous System / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000276:immunology*; D012189:Retrospective Studies
chemical_list: D000912:Antibodies, Neoplasm; D014408:Biomarkers, Tumor
keywords: Cerebrospinal fluid; Intrathecal synthesis; MRI; Onconeural antibodies; Paraneoplastic neurological syndromes