title: Redox-dependent regulation of epidermal growth factor receptor signaling.
abstract: Tyrosine phosphorylation-dependent cell signaling represents a unique feature of multicellular organisms, and is important in regulation of cell differentiation and specialized cell functions. Multicellular organisms also contain a diverse family of NADPH oxidases (NOXs) that have been closely linked with tyrosine kinase-based cell signaling and regulate tyrosine phosphorylation via reversible oxidation of cysteine residues that are highly conserved within many proteins involved in this signaling pathway. An example of redox-regulated tyrosine kinase signaling involves the epidermal growth factor receptor (EGFR), a widely studied receptor system with diverse functions in normal cell biology as well as pathologies associated with oxidative stress such as cancer. The purpose of this Graphical Redox Review is to highlight recently emerged concepts with respect to NOX-dependent regulation of this important signaling pathway.
authors.affiliation: Department of Pathology and Laboratory Medicine, Vermont Lung Center, University of Vermont, Burlington, VT 05405, United States.
authors.forename: David E
authors.initials: DE
authors.lastname: Heppner
authors.affiliation: Department of Pathology and Laboratory Medicine, Vermont Lung Center, University of Vermont, Burlington, VT 05405, United States. Electronic address: albert.van-der-vliet@uvm.edu.
authors.forename: Albert
authors.initials: A
authors.lastname: van der Vliet
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D003545:Cysteine / Q000378:metabolism; D066246:ErbB Receptors / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D019255:NADPH Oxidases / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010766:Phosphorylation; D011485:Protein Binding; D011487:Protein Conformation; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species; D000255:Adenosine Triphosphate; D019255:NADPH Oxidases; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases; D003545:Cysteine
keywords: Cysteine oxidation; EGFR; NADPH oxidase; NOX/DUOX; Tyrosine kinase; Tyrosine phosphatase