title: Alzheimer's disease: the amyloid hypothesis on trial.
abstract: The pathogenesis of Alzheimer's disease is complex. The amyloid hypothesis has directed research efforts for many years, but it has recently been questioned after failed drug trials. Here, we review the evidence for and against and suggest that it might be premature to abandon the amyloid hypothesis.
authors.affiliation: Judith R. Harrison, MBChB, Michael J. Owen, PhD, FRCPsych, MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK harrisonjr1@cardiff.ac.uk.
authors.forename: Judith R
authors.initials: JR
authors.lastname: Harrison
authors.affiliation: Judith R. Harrison, MBChB, Michael J. Owen, PhD, FRCPsych, MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000000981:diagnostic imaging*; D002986:Clinical Trials as Topic; D006801:Humans; D049268:Positron-Emission Tomography
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers