title: A solitary pulmonary ground-glass nodule in adult systemic langerhans' cell histiocytosis.
abstract: During a thoracic computed tomography (CT) scan, a 36-year-old male was diagnosed with a solitary oval pulmonary mixed ground-glass nodule in the right upper lobe of the lung. The edge of the nodule was well-defined, and its largest axial size was approximately 1.1 × 0.9 cm(2). This nodule was slightly lobulated, but not obviously speculated. Solid components, micro-cystic lucency shadow, small high-density rings and tiny vascular branches were all visible in the nodule. During hospitalization, a technetium 99 m methylene diphosphonate (Tc-99 m MDP) bone scan was performed, which showed a skeletal foci with abnormal uptake in the left iliac. A pulmonary lobectomy of the right upper lobe of the lung by video-assisted thoracoscopy was performed. In post-operative pathological photomicrographs, proliferative Langerhans' cells, eosinophils and lymphocytes were found. Immunohistochemistry showed that the expression of S-100 protein, CD1a, and CD68 antigen all stained positive. Since Langerhans' cell histiocytosis (LCH) that is also associated with isolated mixed ground-glass nodules is relatively rare, such a multi-systemic LCH case as identified herein, is reported.
authors.affiliation: Department of Radiology, Shanghai Changzheng Hospital, Second Military Medical University, First People's Hospital Lianyungang 222000, Jiangsu, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Pathobiology, Shanghai Changzheng Hospital, Second Military Medical University Shanghai 200003, China.
authors.forename: Yunyuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Radiology, Shanghai Changzheng Hospital, Second Military Medical University Shanghai 200003, China.
authors.forename: Li
authors.initials: L
authors.lastname: Fan
authors.affiliation: Department of Radiology, Shanghai Changzheng Hospital, Second Military Medical University Shanghai 200003, China.
authors.forename: Shiyuan
authors.initials: S
authors.lastname: Liu
mesh_terms: D000328:Adult; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D003074:Solitary Pulmonary Nodule / Q000473:pathology*
keywords: Histiocytosis; langerhans’ cells; lung; solitary pulmonary nodule