title: Orthogonal chemical functionalization of patterned gold on silica surfaces.
abstract: Single-step orthogonal chemical functionalization procedures have been developed with patterned gold on silica surfaces. Different combinations of a silane and a thiol were simultaneously deposited on a gold/silica heterogeneous substrate. The orthogonality of the functionalization (i.e., selective grafting of the thiol on the gold areas and the silane on the silica) was demonstrated by X-ray photoelectron spectroscopy (XPS) as well as time-of-flight secondary ion mass spectrometry (ToF-SIMS) mapping. The orthogonal functionalization was used to immobilize proteins onto gold nanostructures on a silica substrate, as demonstrated by atomic force microscopy (AFM). These results are especially promising in the development of future biosensors where the selective anchoring of target molecules onto nanostructured transducers (e.g., nanoplasmonic biosensors) is a major challenge.
authors.affiliation: Université de Lyon, Institut des Nanotechnologies de Lyon, site École Centrale de Lyon, CNRS UMR 5270, 36 Avenue Guy de Collongue, 69134 Écully, France.
authors.forename: Francisco
authors.initials: F
authors.lastname: Palazon
authors.affiliation: Université de Lyon, Institut des Sciences Analytiques, Université Claude Bernard Lyon 1 / CNRS / ENS de Lyon, CNRS UMR 5280, 5 rue de la Doua, 69100 Villeurbanne, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Léonard
authors.affiliation: Université de Lyon, École Centrale de Lyon, Laboratoire de Tribologie et Dynamique des Systèmes, CNRS UMR 5513, 36 Avenue Guy de Collongue, 69134 Écully, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Le Mogne
authors.affiliation: Université de Lyon, Institut des Nanotechnologies de Lyon, site École Centrale de Lyon, CNRS UMR 5270, 36 Avenue Guy de Collongue, 69134 Écully, France.
authors.forename: Francesca
authors.initials: F
authors.lastname: Zuttion
authors.affiliation: Laboratoire Nanotechnologies & Nanosystèmes (UMI-LN2 3463), Université de Sherbrooke - CNRS - INSA de Lyon - ECL - UJF-CPE Lyon, Université de Sherbrooke, 3000 Boulevard de l'Université, Sherbrooke, Québec J1K 0A5, Canada,; LTM/CNRS/RENATECH, 17 rue des martyrs, 38054 Grenoble, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Chevalier
authors.affiliation: Université de Lyon, Institut des Nanotechnologies de Lyon, site École Centrale de Lyon, CNRS UMR 5270, 36 Avenue Guy de Collongue, 69134 Écully, France.
authors.forename: Magali
authors.initials: M
authors.lastname: Phaner-Goutorbe
authors.affiliation: Université de Lyon, Institut des Nanotechnologies de Lyon, site École Centrale de Lyon, CNRS UMR 5270, 36 Avenue Guy de Collongue, 69134 Écully, France.
authors.forename: Éliane
authors.initials: É
authors.lastname: Souteyrand
authors.affiliation: Université de Lyon, Institut des Nanotechnologies de Lyon, site École Centrale de Lyon, CNRS UMR 5270, 36 Avenue Guy de Collongue, 69134 Écully, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Chevolot
authors.affiliation: Université de Lyon, Institut des Nanotechnologies de Lyon, site École Centrale de Lyon, CNRS UMR 5270, 36 Avenue Guy de Collongue, 69134 Écully, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Cloarec
keywords: ToF–SIMS; XPS; characterization; self-assembled monolayer; surface functionalization