title: Transdermal Wound Oxygen Therapy on Pressure Ulcer Healing: A Single-Blind Multi-Center Randomized Controlled Trial.
abstract: BACKGROUND
  Although healthcare quality has considerably improved in many countries, pressure ulcer is still a major health challenge worldwide.
  
  
  OBJECTIVE
  The current study aimed to evaluate the effects of TWOT on the healing of pressure ulcers.
  
  
  METHODS
  This study was a randomized controlled trial, and the convenient sample including 100 patients hospitalized in two university-affiliated medical-surgical intensive care units and one neurology unit located in Qazvin, Iran were studied. Patients with stage II-IV pressure ulcer on the sacral or ischial areas were randomly assigned to either the control or the experimental groups. The experimental group received a 12-day transdermal wound oxygen therapy. Wound status was assessed seven times before the intervention, as well as two, four, six, eight, ten, and twelve days after the intervention.
  
  
  RESULTS
  After 12 days of wound oxygen therapy, the number of patients with complete wound healing in the experimental group was significantly greater than that of the control group. Moreover, the total mean of wound area in the experimental group was significantly lower than that of the control group.
  
  
  CONCLUSIONS
  Transdermal wound oxygen therapy can effectively promote wound healing in patients with pressure ulcers.
authors.affiliation: Nursing and Midwifery Faculty, School of Nursing and Midwifery, Qazvin University of Medical Sciences, Qazvin, IR Iran; Nursing and Midwifery Faculty, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Jalil
authors.initials: J
authors.lastname: Azimian
authors.affiliation: Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, IR Iran.
authors.forename: Nahid
authors.initials: N
authors.lastname: Dehghan Nayeri
authors.affiliation: Department of Nursing, Qazvin University of Medical Sciences, Kosar General Hospital, Qazvin, IR Iran.
authors.forename: Enis
authors.initials: E
authors.lastname: Pourkhaleghi
authors.affiliation: Department of Nursing, Qazvin University of Medical Sciences, Boali Medical Hospital, Qazvin, IR Iran.
authors.forename: Monireh
authors.initials: M
authors.lastname: Ansari
keywords: Oxygen Therapy; Pressure Ulcer; Wounds