title: AIE Luminogen-Functionalized Hollow Mesoporous Silica Nanospheres for Drug Delivery and Cell Imaging.
abstract: Hollow mesoporous silica nanospheres functionalized with aggregation-induced emission (AIE) luminogen tetraphenylethene were prepared by postgrafting method. The as-prepared inorganic-organic hybrid nanospheres show bright blue emission and good biocompatibility as shown by MTT assays. The large cavities of the materials enable high loading of the anticancer drug doxorubicin hydrochloride (DOX), and the mesoporous silica shells allow pH-dependent drug release. The materials can be effectively taken up by cells and function as luminescent bioprobes, demonstrating their potential application in imaging-guided therapy.
authors.affiliation: State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P.R. China.
authors.forename: Zhiying
authors.initials: Z
authors.lastname: Fan
authors.affiliation: State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P.R. China.|Department of Materials Science, Jilin University, 2699 Qianjin Street, Changchun, 130012, P.R. China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Li
authors.affiliation: School of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, P.R. China.
authors.forename: Xue
authors.initials: X
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P.R. China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cai
authors.affiliation: School of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, P.R. China.
authors.forename: Jingji
authors.initials: J
authors.lastname: Jin
authors.affiliation: State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P.R. China. jihong@jlu.edu.cn.
authors.forename: Jihong
authors.initials: J
authors.lastname: Yu
mesh_terms: D045744:Cell Line, Tumor; D003952:Diagnostic Imaging; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D049449:Luminescence; D054118:Nanospheres / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D012822:Silicon Dioxide; D004317:Doxorubicin
keywords: aggregation-induced emission; drug delivery; imaging agents; mesoporous materials; nanostructures