title: MID TERM RESULTS AFTER OPEN HEART SURGERY IN HEMODIALYSIS PATIENTS AWAITING KIDNEY TRANSPLANT: DOES CARDIOVASCULAR SURGICAL INTERVENTION PRIOR TO TRANSPLANTATION PROLONG SURVIVAL?
abstract: The aim of this study was to compare the mid and long term postoperative outcomes between the hemodialysis-dependent patients awaiting kidney transplantat who underwent open heart surgery in our department during the last five years, and those who did not receive a renal transplant, to determine the predictors of mortality, and assess the possible contribution of post heart surgery kidney transplantation to survival. The patients were separated into two groups: those who underwent a transplantation after open heart surgery were included in the Tp+ group, and those who did not in the Tp- group Between June 2008 and December 2012, 127 dialysis dependent patients awaiting kidney transplant and who underwent open heart surgery were separated into two groups. Those who underwent transplantation after open heart surgery were determined as Tp+ (n=33), and those who did not as Tp- (n=94). Both groups were compared with respect to preoperative paramaters including age, sex, diabetes mellitus (DM), hypertension (HT), hyperlipidemia (HL), obesity, smoking, chronic obstructive pulmonary disease (COPD), peripheral vascular disease (PVD), left ventricle ejection fraction (EF), Euroscore; operative parameters including cross clamp time, perfusion time, number of grafts, use of internal mammary artery (IMA); postoperative parameters including revision, blood transfusion, ventilation time, use of inotropic agents, length of stay in the intensive care unit and hospital, and follow up findings. Problems encountered during follow up were recorded. Predictors of mortality were determined and the survival was calculated. Among the preoperative parameters, when compared with the Tp- group, the Tp+ group had significantly lower values in mean age, presence of DM, obesity, PVD, and Euroscore levels, and higher EF values. Assessment of postoperative values showed that blood transfusion requirement and length of hospital stay were significantly lower in the Tp+ group compared to the Tp- group, whereas the length of follow up was significantly higher in the Tp+ group. The use of inotropic agents was significantly higher in the Tp- group. A logistic regression analysis was made to determine the factors affecting mortality. Revision (p=0.013), blood transfusion (p=0.017), ventilation time (p=0.019), and length of stay in the intensive care unit (p=0.009) were found as predictors of mortality. Survival rates at years 1, 2 and 3 were 86.1%, 81%, 77.5% in the Tp- group, and 96.0%, 96.3%, 90.4% in the Tp+ group. Median survival rate was 41.35±2.02 in the Tp- group, and 49.64±1.59 in the Tp+ group which was significantly higher compared to the Tp- group (p=0.048). Chronic renal failure is among the perioperative risk factors for patients undergoing open heart surgery. Transplantation is still an important health issue due to insufficiency of available transplant organs. Patients with chronic renal failure are well known to have higher risks for coronary artery disease. A radical solution of the cardiovascular system problems prior to kidney transplantation seems to have a significant contribution to the post transplant survival.
authors.affiliation: Gaziosmanpasa Hospital, Cardiovascular Surgery Department; Istanbul Bilim University, Thoracic Surgery Department; Gaziosmanpasa Hospital, Cardiology Department; Istanbul University, Medical Faculty, Department of Cardiovascular Surgery; Gaziosmanpasa Hospital, Transplantation Department, Istanbul, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Ozbek
authors.affiliation: Gaziosmanpasa Hospital, Cardiovascular Surgery Department; Istanbul Bilim University, Thoracic Surgery Department; Gaziosmanpasa Hospital, Cardiology Department; Istanbul University, Medical Faculty, Department of Cardiovascular Surgery; Gaziosmanpasa Hospital, Transplantation Department, Istanbul, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Sever
authors.affiliation: Gaziosmanpasa Hospital, Cardiovascular Surgery Department; Istanbul Bilim University, Thoracic Surgery Department; Gaziosmanpasa Hospital, Cardiology Department; Istanbul University, Medical Faculty, Department of Cardiovascular Surgery; Gaziosmanpasa Hospital, Transplantation Department, Istanbul, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Demirhan
authors.affiliation: Gaziosmanpasa Hospital, Cardiovascular Surgery Department; Istanbul Bilim University, Thoracic Surgery Department; Gaziosmanpasa Hospital, Cardiology Department; Istanbul University, Medical Faculty, Department of Cardiovascular Surgery; Gaziosmanpasa Hospital, Transplantation Department, Istanbul, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Mansuroglu
authors.affiliation: Gaziosmanpasa Hospital, Cardiovascular Surgery Department; Istanbul Bilim University, Thoracic Surgery Department; Gaziosmanpasa Hospital, Cardiology Department; Istanbul University, Medical Faculty, Department of Cardiovascular Surgery; Gaziosmanpasa Hospital, Transplantation Department, Istanbul, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Kurtoglu
authors.affiliation: Gaziosmanpasa Hospital, Cardiovascular Surgery Department; Istanbul Bilim University, Thoracic Surgery Department; Gaziosmanpasa Hospital, Cardiology Department; Istanbul University, Medical Faculty, Department of Cardiovascular Surgery; Gaziosmanpasa Hospital, Transplantation Department, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Ugurlucan
authors.affiliation: Gaziosmanpasa Hospital, Cardiovascular Surgery Department; Istanbul Bilim University, Thoracic Surgery Department; Gaziosmanpasa Hospital, Cardiology Department; Istanbul University, Medical Faculty, Department of Cardiovascular Surgery; Gaziosmanpasa Hospital, Transplantation Department, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Sevmis
authors.affiliation: Gaziosmanpasa Hospital, Cardiovascular Surgery Department; Istanbul Bilim University, Thoracic Surgery Department; Gaziosmanpasa Hospital, Cardiology Department; Istanbul University, Medical Faculty, Department of Cardiovascular Surgery; Gaziosmanpasa Hospital, Transplantation Department, Istanbul, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Karakayali
mesh_terms: D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures / Q000379:methods* / Q000401:mortality; D003324:Coronary Artery Disease / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D003920:Diabetes Mellitus / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D016030:Kidney Transplantation; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000503:physiopathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology; D006435:Renal Dialysis; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors