title: The analysis of association between SNCA, HUSEYO and CSMD1 gene variants and Parkinson's disease in Iranian population.
abstract: Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. Both genetic and environmental factors are involved in the etiology of the disease. Many studies have revealed the susceptibility genes and variations for PD which need further confirmation. Here we evaluated the association of variations in SNCA, HUSEYO and CSMD1 genes with PD. A case-control study was conducted with 489 PD patients and 489 healthy controls. DNA was extracted from peripheral blood of all subjects and rs356220 and rs11931074 in SNCA, rs2338971 in HUSEYO and rs12681349 in CSMD1 were genotyped using PCR-RFLP method. The genotypes and allele frequencies were significantly different between case and control groups for rs356220, rs11931074 and rs2338971 but not for rs12681349. We provided further evidence that rs356220 is associated with increased risk of PD supporting previous studies in Caucasian-based and Japanese populations. The association of rs11931074 with decreased risk of PD was also significant. This study revealed the first evidence of the association of rs2338971 with increased risk of PD in the Iranian population. Nevertheless, these findings need further validation via more replication studies.
authors.affiliation: Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Neda
authors.initials: N
authors.lastname: Shahmohammadibeni
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Simin
authors.initials: S
authors.lastname: Rahimi-Aliabadi
authors.affiliation: Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Jamshidi
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Emamalizadeh
authors.affiliation: Neurology Department, Jondi-Shapoor University of Medical Sciences, Ahwaz, Iran.
authors.forename: Hossein Ali
authors.initials: HA
authors.lastname: Shahmohammadibeni
authors.affiliation: Thrombosis Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Zare Bidoki
authors.affiliation: Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Haleh
authors.initials: H
authors.lastname: Akhavan-Niaki
authors.affiliation: Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Hajar
authors.initials: H
authors.lastname: Eftekhari
authors.affiliation: Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Shokoufeh
authors.initials: S
authors.lastname: Abdollahi
authors.affiliation: Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.|Neurosceinces Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Shekari Khaniani
authors.affiliation: Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Shahmohammadibeni
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Atena
authors.initials: A
authors.lastname: Fazeli
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Motallebi
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Shaghayegh
authors.initials: S
authors.lastname: Taghavi
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Ahmadifard
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Amir Ehtesham
authors.initials: AE
authors.lastname: Shafiei Zarneh
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Monavvar
authors.initials: M
authors.lastname: Andarva
authors.affiliation: Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Dadkhah
authors.affiliation: Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Ehteram
authors.initials: E
authors.lastname: Khademi
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Alehabib
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mahnoosh
authors.initials: M
authors.lastname: Rahimi
authors.affiliation: Department of Neurology, School of Medicine, Imam Khomeini Hospital, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Tafakhori
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Minoo
authors.initials: M
authors.lastname: Atakhorrami
authors.affiliation: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. darvish_mg@sbmu.ac.ir.
authors.forename: Hossein
authors.initials: H
authors.lastname: Darvish
mesh_terms: D000368:Aged; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007492:Iran; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D025521:Tumor Suppressor Proteins; D051844:alpha-Synuclein / Q000235:genetics*
chemical_list: C477880:CSMD1 protein, human; D008565:Membrane Proteins; C497604:SNCA protein, human; D025521:Tumor Suppressor Proteins; D051844:alpha-Synuclein
keywords: CSMD1; HUSEYO; Iranian; Parkinson’s disease; Polymorphism; SNCA