title: Association between Manganese Superoxide Dismutase (MnSOD Val-9Ala) genotypes with the risk of generalized aggressive periodontitis disease.
abstract: Generalized aggressive periodontitis (GAP) is a subtype of periodontal diseases that characterized by rapid destruction of periodontal supporting tissues. The MnSOD Val-9Ala mutation of manganese superoxide dismutase gene (MnSOD Val-9Ala) and its correlation with periodontal diseases has been studied in different populations. The purpose of this study was to investigate the possible association of MnSODVal-9Ala polymorphism with periodontitis disease in sample of GAP patients in Iran for the first time. Following a GAP examination, 50 GAP patients and 100 healthy individuals were recruited. Genomic DNA was extracted from peripheral blood leukocytes and the MnSODVal-9Ala polymorphismwas detected using PCR-RFLP method. The frequency of Ala/Ala, Ala/Val and Val/Val genotypes in healthy individuals were 25, 66 and 9%, respectively. In periodontitis patients, frequencies were as Ala/Ala (12%), Ala/Val (50%) and Val/Val (38%) genotypes. There was a significant positive association between distribution of MnSOD Val-9Ala genotypes and the risk of periodontitis disease (p<0.05). Our results indicated that MnSOD Val-9Ala gene polymorphism has a positive association with the risk of periodontitis disease.
authors.affiliation: Kermanshah University of Medical Sciences Medical Biology Research Center Kermanshah Iran.
authors.forename: E
authors.initials: E
authors.lastname: Kazemi
authors.affiliation: Kermanshah University of Medical Sciences Fertility and Infertility Research Center Kermanshah Iran.
authors.forename: M-T
authors.initials: MT
authors.lastname: Moradi
authors.affiliation: Kermanshah University of Medical Sciences Medical Biology Research Center Kermanshah Iran Kyari@kums.ac.ir.
authors.forename: K
authors.initials: K
authors.lastname: Yari
authors.affiliation: The Scripps Research Institute Howard Hughes Medical Institute, Molecular and Cellular Neuroscience La Jolla USA.
authors.forename: S A R
authors.initials: SA
authors.lastname: Mousavi
authors.affiliation: Incubator Center of Razi University Zagros Bioidea Laboratory Kermanshah Iran.
authors.forename: D
authors.initials: D
authors.lastname: Kahrizi
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran; D007963:Leukocytes, Mononuclear / Q000378:metabolism* / Q000473:pathology; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012306:Risk; D013482:Superoxide Dismutase / Q000235:genetics*; D000099156:Superoxide Dismutase 2
chemical_list: D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2