title: Association of ICAM-1 and HMGA1 Gene Variants with Retinopathy in Type 2 Diabetes Mellitus Among Chinese Individuals.
abstract: To evaluate the association of intercellular cell-adhesion molecule 1 (ICAM-1) and high-mobility group A1 (HMGA1) gene variants with diabetic retinopathy (DR) in a Chinese type 2 diabetes mellitus (T2DM) cohort.
  
  
  
  A total of 792 patients with T2DM were enrolled and categorized into two groups: (1) the DR group consisted of 448 patients, which was further subclassified into the proliferative DR (PDR) group with 220 patients and the nonproliferative DR (NPDR) group with 228 patients; (2) the diabetes without retinopathy (DNR) group comprised 344 patients who had no signs of DR. The single-nucleotide polymorphism (SNP) rs5498 in ICAM-1 gene and IVS5-13insC variant in HMGA1 gene were genotyped.
  
  
  
  No evident association was found in the allele frequencies between SNP rs5498 in ICAM-1 gene and DR patients; the combined p values for the additive, dominant, and recessive models in genotype were greater than 0.05. No significant association was identified between the IVS5-13insC variant in HMGA1 gene and DR individuals.
  
  
  
  Our results revealed that SNP rs5498 in ICAM-1 gene and IVS5-13insC variant in HMGA1 gene were not associated with the susceptibility of DR in the Chinese T2DM cohort.
authors.affiliation: a Department of Ophthalmology , Qilu Hospital of Shandong University , Jinan , China.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Lv
authors.affiliation: a Department of Ophthalmology , Qilu Hospital of Shandong University , Jinan , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: b State Key Lab of Crystal Materials, Shandong University , Jinan , China.
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Wu
authors.affiliation: a Department of Ophthalmology , Qilu Hospital of Shandong University , Jinan , China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Qu
mesh_terms: D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D025741:HMGA1a Protein / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D015994:Incidence; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012189:Retrospective Studies
chemical_list: D025741:HMGA1a Protein; D018799:Intercellular Adhesion Molecule-1
keywords: High-mobility group A1; intercellular cell-adhesion molecule 1; retinopathy; type 2 diabetes mellitus