title: [Effects of rocuronium on gastric insufflation related to facemask ventilation in general anaesthesia patients].
abstract: OBJECTIVE
  To explore the effect of rocuronium on gastric insufflation related to facemask ventilation in general anaesthesia patients.
  
  
  METHODS
  Eighty patients from June to October 2015 undergoing elective operation under general anaesthesia at Ningbo NO.2 Hospital , ASA I or II grade, aged 18-65, were enrolled in this study and divided into two groups (n=40): Group R (rocuronium) and Group C (for control). Facemask pressure-controlled ventilation was started after general anaesthesia induced with propofol and remifentanil for a 2 min period while gastric insufflation was detected by ultrasonography of the antrum. The cross-sectional antral area (CSA) was measured using ultrasonography before and after facemask ventilation. Respiratory parameters were also recorded.
  
  
  RESULTS
  Compared to the antral area before FMV, the CSA significantly increased in group R and C after FMV [post-FMV:(579.5 ± 167.3), (508.1 ± 112.2)mm²; pre-FMV(479.4 ± 110.2), (451.2 ± 103.4) mm²; t=5.938, 4.302, P<0.001]. All the patients were divided into four subgroups according to the gastric insufflation (R+, R-, C +, C-) and there were significant increases in the values of CSA before and after FMV in groups R+ and C+[post-FMV(647.7 ± 150.6), (546.2 ± 121.1) mm²; pre-FMV (501.2 ± 113.6), (422.6 ± 101.5) mm²; t=7.885, 8.719, P<0.001], without any significant increase in groups R- and C-[post-FMV(496.0 ± 150.9), (489.8 ± 105.1) mm²; pre-FMV (452.9 ± 102.8), (465.0 ± 103.3) mm²; t=1.793, 1.663, P>0.05]. Compared with the group R- , the CSA of group R+ significantly increased before and after FMV[group R+ (146.6 ± 87.2) mm²; group R- (43.1 ± 102.1) mm²; t=3.458, P<0.001]; compared with the group C- , the CSA of group C+ significantly increased before and after FMV [group C+ (123.6 ± 51.1) mm²; group C- (24.8 ± 77.4) mm²; t=4.172, P<0.001]; there was no significant difference between the difference value of CSA in groups R+ and C+ before and after FMV (t=0.983, P>0.05). The incidence of gastric insufflation was 55% and 32.5% in group R and C, respectively (χ² =4.114, P<0.05). There was no significant difference in respiratory parameters between group R and C.
  
  
  CONCLUSIONS
  The study suggests that rocuronium may promote gastric insufflation related to facemask ventilation (15 cmH₂O PCV)in general anaesthesia patients.
authors.affiliation: Department of Anesthesiology, the First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou 310003, China.
authors.forename: Chunying
authors.initials: C
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Lu
authors.forename: Bo
authors.initials: B
authors.lastname: Meng
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Fan
authors.forename: Guorong
authors.initials: G
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Junping
authors.initials: J
authors.lastname: Chen
authors.affiliation: Email: smzhu20088@163.com.
authors.forename: Shengmei
authors.initials: S
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000732:Androstanols; D000768:Anesthesia, General; D000769:Anesthesia, Inhalation; D003430:Cross-Sectional Studies; D006801:Humans; D007327:Insufflation; D017214:Laryngeal Masks; D008875:Middle Aged; D010880:Piperidines; D015742:Propofol; D000077208:Remifentanil; D000077123:Rocuronium; D013270:Stomach; D055815:Young Adult
chemical_list: D000732:Androstanols; D010880:Piperidines; D000077208:Remifentanil; D000077123:Rocuronium; D015742:Propofol