title: Association of age and admission mean arterial blood pressure in patients with stroke-data from a national stroke registry.
abstract: Elevated blood pressure (BP) upon admission is common in patients with ischemic stroke (IS) and intracerebral hemorrhage (ICH). Older patients have a higher prevalence of stroke, but data on admission mean arterial pressure (MAP) patterns in older patients with stroke are scarce. All 6060 patients with IS (72%), ICH (8%) and transient ischemic attack (TIA; 20%) with data on BP and hypertension status on admission in the National Acute Stroke Israeli Registry were included. Admission MAP in the emergency department was studied by age group (<60, 60-74 and ⩾75 years) and stroke type. Linear regression models for admission MAP were produced, including age group, gender, hypertension status and stroke severity as covariates. Interactions between hypertension and age were assessed. Lower MAP (s.d.) was associated with older ages in hypertensive patients (113 (18) mm Hg for age <60 years, 109 (17) for age 60-74 years and 108 (19) for age ⩾75 years, P<0.0001) but not in non-hypertensive IS patients. Among patients with ICH and TIA, a significant negative association of MAP with age was observed for hypertensive patients (P=0.015 and P=0.023, respectively), whereas a significant positive association with age was found in non-hypertensive patients (P=0.023 and P=0.038, respectively). In adjusted regression models, MAP was significantly associated with hypertension in IS, ICH and TIA patients. The interaction between hypertension and age was significantly associated with MAP in IS and ICH patients. In hypertensive patients, the average admission MAP was lower in persons at older ages.
authors.affiliation: Department of Endocrinology, Diabetes and Metabolism, Clalit Health Services, Tel Aviv-Yaffo district, Israel.
authors.forename: Yoav
authors.initials: Y
authors.lastname: Eizenberg
authors.affiliation: Stanley Steyer School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Silvia
authors.initials: S
authors.lastname: Koton
authors.affiliation: Neurology Department and Joseph Sagol Neuroscience Center, The Chaim Sheba Medical Center, Affiliated to the Sackler School of Medicine, Tel Aviv University, Tel-Hashomer, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Tanne
authors.affiliation: Internal Medicine Department D and Hypertension Unit, The Chaim Sheba Medical Center, Affiliated to the Sackler School of Medicine, Tel Aviv University, Tel-Hashomer, Israel.
authors.forename: Ehud
authors.initials: E
authors.lastname: Grossman
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D062186:Arterial Pressure / Q000502:physiology*; D002543:Cerebral Hemorrhage / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010343:Patient Admission; D011379:Prognosis; D012042:Registries; D012307:Risk Factors; D020521:Stroke / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*