title: Retinal and Choroidal Thickness in Patients with Uveitis.
abstract: OBJECTIVE
  To study retinal thickness (RT) and choroidal thickness (CT) in patients with inactive uveitis. We also investigated the correlation between RT and CT and the duration and frequency of inflammation and visual acuity in patients with inactive uveitis.
  
  
  METHODS
  One-hundred and forty-eight eyes from 97 patients (mean age 51.0 ± 15.7 years) and 98 eyes from 55 normal subjects (mean age 59.3 ± 14.4 years) were studied. Routine ophthalmic examination included spectral-domain optical coherence tomography with enhanced depth imaging of the retina and choroid. CT was measured from the outer border of the retinal pigment epithelium to the inner scleral border at 500-µm intervals of the horizontal section between 2.5 mm temporal and 2.5 mm nasal to the fovea. RT was measured between the inner limiting membrane and the retinal pigment epithelium.
  
  
  RESULTS
  Mean subfoveal RT did not differ significantly between uveitis patients and controls. Mean CT at multiple locations was significantly lower in patients with uveitis compared to normal subjects; this difference was most significant at the fovea (uveitis group, 229 ± 85 µm vs. control group, 276 ± 74 µm; p < 0.001). Only CT was associated with duration and frequency of inflammation in patients with anterior uveitis (r = -0.298, p = 0.008; r = -0.349, p = 0.002, respectively).
  
  
  CONCLUSIONS
  CT is reduced in patients with inactive uveitis and is associated with disease duration and frequency whereas RT does not seem to be affected by disease processes.
authors.affiliation: a Department of Ophthalmology , Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education Beijing , Beijing , China.
authors.forename: Honggai
authors.initials: H
authors.lastname: Yan
authors.affiliation: a Department of Ophthalmology , Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education Beijing , Beijing , China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: a Department of Ophthalmology , Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education Beijing , Beijing , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: a Department of Ophthalmology , Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education Beijing , Beijing , China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
mesh_terms: D002829:Choroid / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012160:Retina / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014605:Uveitis / Q000150:complications* / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology
keywords: choroidal thickness; inactive uveitis; optical coherence tomography; retinal thickness; uveitis