title: Fecal calprotectin correlated with endoscopic remission for Asian inflammatory bowel disease patients.
abstract: OBJECTIVE
  To evaluate the correlation between fecal calprotectin (fC), C-reactive protein (CRP), and endoscopic disease score in Asian inflammatory bowel disease (IBD) patients.
  
  
  METHODS
  Stool samples were collected and assessed for calprotectin levels by Quantum Blue Calprotectin High Range Rapid test. Crohn's disease endoscopic index of severity (CDEIS) and ulcerative colitis endoscopic index of severity (UCEIS) were used for endoscopic lesion scoring.
  
  
  RESULTS
  A total of 88 IBD patients [36 patients with Crohn's disease (CD) and 52 with ulcerative colitis (UC)] were enrolled. For CD patients, fC correlated with CDEIS (r = 0.465, P = 0.005) and CRP (r = 0.528, P = 0.001). fC levels in UC patients correlated with UCEIS (r = 0.696, P < 0.0001) and CRP (r = 0.529, P = 0.0005). Calprotectin could predict endoscopic remission (CDEIS < 6) with 50% sensitivity and 100% specificity (AUC: 0.74) in CD patients when using 918 μg/g as the cut-off. When using 191 μg/g as the cut-off in UC patients, calprotectin could be used for predicting endoscopic remission (UCEIS < 3) with 88% sensitivity and 75% specificity (AUC: 0.87).
  
  
  CONCLUSIONS
  fC correlated with both CDEIS and UCEIS. fC could be used as a predictor of endoscopic remission for Asian IBD patients.
authors.affiliation: Wei-Chen Lin, Horng-Yuan Wang, Division of Gastroenterology, Department of internal Medicine, Mackay Memorial Hospital, Taipei 104, Taiwan.
authors.forename: Wei-Chen
authors.initials: WC
authors.lastname: Lin
authors.affiliation: Wei-Chen Lin, Horng-Yuan Wang, Division of Gastroenterology, Department of internal Medicine, Mackay Memorial Hospital, Taipei 104, Taiwan.
authors.forename: Jau-Min
authors.initials: JM
authors.lastname: Wong
authors.affiliation: Wei-Chen Lin, Horng-Yuan Wang, Division of Gastroenterology, Department of internal Medicine, Mackay Memorial Hospital, Taipei 104, Taiwan.
authors.forename: Chien-Chih
authors.initials: CC
authors.lastname: Tung
authors.affiliation: Wei-Chen Lin, Horng-Yuan Wang, Division of Gastroenterology, Department of internal Medicine, Mackay Memorial Hospital, Taipei 104, Taiwan.
authors.forename: Ching-Pin
authors.initials: CP
authors.lastname: Lin
authors.affiliation: Wei-Chen Lin, Horng-Yuan Wang, Division of Gastroenterology, Department of internal Medicine, Mackay Memorial Hospital, Taipei 104, Taiwan.
authors.forename: Jen-Wei
authors.initials: JW
authors.lastname: Chou
authors.affiliation: Wei-Chen Lin, Horng-Yuan Wang, Division of Gastroenterology, Department of internal Medicine, Mackay Memorial Hospital, Taipei 104, Taiwan.
authors.forename: Horng-Yuan
authors.initials: HY
authors.lastname: Wang
authors.affiliation: Wei-Chen Lin, Horng-Yuan Wang, Division of Gastroenterology, Department of internal Medicine, Mackay Memorial Hospital, Taipei 104, Taiwan.
authors.forename: Ming-Jium
authors.initials: MJ
authors.lastname: Shieh
authors.affiliation: Wei-Chen Lin, Horng-Yuan Wang, Division of Gastroenterology, Department of internal Medicine, Mackay Memorial Hospital, Taipei 104, Taiwan.
authors.forename: Chin-Hao
authors.initials: CH
authors.lastname: Chang
authors.affiliation: Wei-Chen Lin, Horng-Yuan Wang, Division of Gastroenterology, Department of internal Medicine, Mackay Memorial Hospital, Taipei 104, Taiwan.
authors.forename: Heng-Hsiu
authors.initials: HH
authors.lastname: Liu
authors.affiliation: Wei-Chen Lin, Horng-Yuan Wang, Division of Gastroenterology, Department of internal Medicine, Mackay Memorial Hospital, Taipei 104, Taiwan.
authors.forename: Shu-Chen
authors.initials: SC
authors.lastname: Wei
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D003093:Colitis, Ulcerative / Q000208:ethnology / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D003106:Colon / Q000737:chemistry* / Q000187:drug effects* / Q000473:pathology*; D003113:Colonoscopy; D003424:Crohn Disease / Q000208:ethnology / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012074:Remission Induction; D012720:Severity of Illness Index; D013624:Taiwan; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex; D002097:C-Reactive Protein
keywords: Crohn’s disease; Endoscopic score; Fecal calprotectin; Inflammatory bowel disease; Ulcerative colitis