title: Corticosteroid Use in a Prospective, Community-Based Cohort of Newly Diagnosed Inflammatory Bowel Disease Patients.
abstract: Systemic corticosteroids (CS) are a mainstay of treatment for patients with newly diagnosed inflammatory bowel disease (IBD). Previous population-based studies report CS exposure rates range from 39 to 75 % within the first year of diagnosis with surgical resection rates as high as 13-18 % in the same time frame. These reports represent an older cohort of patients enrolled over prolonged periods of time and do not necessarily reflect current treatment approaches. We examine CS use during the first year of IBD diagnosis in a community-based, inception cohort.
  
  
  
  Data were derived from the Ocean State Crohn's and Colitis Area Registry (OSCCAR), a prospective inception cohort of IBD patients who are residents of Rhode Island.
  
  
  
  A total of 272 patients were included in the current analyses. Overall, 60 % of Crohn's disease and 57 % of ulcerative colitis patients were exposed to at least one course of CS during year 1 of study enrollment. Most notably, only 2 % of patients (n = 5) required a surgical resection.
  
  
  
  In this community-based cohort, 59 % of patients were exposed to at least one course of CS during their first year of enrollment. In contrast to previous studies, OSCCAR represents a more modern cohort of patients. While steroid exposure rates were similar or slightly higher than those in previous reports, we observed a low rate of surgical resection. As our cohort ages, future analysis will focus on the role more contemporary agents may play on the low rates of surgery we observed.
authors.affiliation: Division of Gastroenterology, Nutrition and Liver Diseases, Hasbro Children's Hospital/Rhode Island Hospital, 593 Eddy Street, 132 Multiphasic Building, Providence, RI, 02903, USA. jshapiro@lifespan.org.|The Warren Alpert School of Medicine at Brown University, Providence, RI, USA. jshapiro@lifespan.org.
authors.forename: Jason M
authors.identifier: 0000-0002-7211-7430
authors.initials: JM
authors.lastname: Shapiro
authors.affiliation: Division of Child and Adolescent Psychiatry, the Department of Psychiatry, Hasbro Children's Hospital/Rhode Island Hospital, Providence, RI, USA.|The Warren Alpert School of Medicine at Brown University, Providence, RI, USA.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Hagin
authors.affiliation: The Warren Alpert School of Medicine at Brown University, Providence, RI, USA.|Gastroenterology Associates, Inc., Providence, RI, USA.
authors.forename: Samir A
authors.initials: SA
authors.lastname: Shah
authors.affiliation: Division of Gastroenterology, Rhode Island Hospital, Providence, RI, USA.
authors.forename: Renee
authors.initials: R
authors.lastname: Bright
authors.affiliation: Division of Gastroenterology, Rhode Island Hospital, Providence, RI, USA.
authors.forename: Meaghan
authors.initials: M
authors.lastname: Law
authors.affiliation: Division of Gastroenterology, Rhode Island Hospital, Providence, RI, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Moniz
authors.affiliation: Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Giacalone
authors.affiliation: Division of Gastroenterology, Nutrition and Liver Diseases, Hasbro Children's Hospital/Rhode Island Hospital, 593 Eddy Street, 132 Multiphasic Building, Providence, RI, 02903, USA.
authors.forename: Taylor
authors.initials: T
authors.lastname: Jackvony
authors.affiliation: The Warren Alpert School of Medicine at Brown University, Providence, RI, USA.|Division of Gastroenterology, Rhode Island Hospital, Providence, RI, USA.
authors.forename: Sasha
authors.initials: S
authors.lastname: Taleban
authors.affiliation: Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, Georgia.
authors.forename: Zahid
authors.initials: Z
authors.lastname: Samad
authors.affiliation: Crohn's and Colitis Foundation of America, New York, NY, USA.
authors.forename: Marjorie
authors.initials: M
authors.lastname: Merrick
authors.affiliation: Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Sands
authors.affiliation: Division of Gastroenterology, Nutrition and Liver Diseases, Hasbro Children's Hospital/Rhode Island Hospital, 593 Eddy Street, 132 Multiphasic Building, Providence, RI, 02903, USA.|The Warren Alpert School of Medicine at Brown University, Providence, RI, USA.
authors.forename: Neal S
authors.initials: NS
authors.lastname: LeLeiko
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D002648:Child; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D003424:Crohn Disease / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Corticosteroids; Crohn’s disease; Inflammatory bowel disease; Surgical resections; Ulcerative colitis