title: Bioresorbable vascular scaffolds: design, clinical trials, and current applications.
abstract: In recent years, bioresorbable vascular scaffolds (BVS) have been introduced into clinical practice. The main advantage of BVS is that they overcome the problem of the foreign body in the treated artery. BVS, once placed into narrowed coronary vessels, behave like a conventional drug-eluting stent, but a device that disappears over time can preserve the anatomy and physiology of the treated vessel. The progression of stenosis after stenting has been attributed, at least in part, to inflammation around metallic struts, that, however, disappears gradually when using BVS. BVS have proven to be effective and safe as drug-eluting stents; in fact, the rate of adverse cardiovascular events and scaffold thrombosis in patients is low. The aim of this review article is to provide a comprehensive and updated description of the status of the art on BVS, highlighting the current evidence and future perspectives of this technology.
authors.affiliation: aDepartment of Emergency and Organ Transplantation, Section of Cardiovascular Diseases, School of Medicine, University of Bari, Bari bCardiology Department, University of Foggia, Foggia, Italy cDepartment of Internal Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine University dSystematic Investigation and Research on Interventions and Outcomes (SIRIO) MEDICINE Research Network, Düsseldorf, Germany eCochrane Heart Group, London, UK.
authors.forename: Fiorella
authors.initials: F
authors.lastname: Devito
authors.forename: Annapaola
authors.initials: A
authors.lastname: Zito
authors.forename: Annamaria
authors.initials: A
authors.lastname: Dachille
authors.forename: Rosa
authors.initials: R
authors.lastname: Carbonara
authors.forename: Francesco
authors.initials: F
authors.lastname: Giardinelli
authors.forename: Gabriella
authors.initials: G
authors.lastname: Bulzis
authors.forename: Eliano P
authors.initials: EP
authors.lastname: Navarese
authors.forename: Pietro
authors.initials: P
authors.lastname: Scicchitano
authors.forename: Antonio
authors.initials: A
authors.lastname: Gaglione
authors.forename: Filippo
authors.initials: F
authors.lastname: Masi
authors.forename: Marco M
authors.initials: MM
authors.lastname: Ciccone
mesh_terms: D020341:Absorbable Implants; D001807:Blood Vessel Prosthesis; D003324:Coronary Artery Disease / Q000601:surgery*; D023903:Coronary Restenosis; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000295:instrumentation / Q000379:methods; D054457:Tissue Scaffolds