title: Diverse Nrf2 Activators Coordinated to Cobalt Carbonyls Induce Heme Oxygenase-1 and Release Carbon Monoxide in Vitro and in Vivo.
abstract: The Nrf2/heme oxygenase-1 (HO-1) axis affords significant protection against oxidative stress and cellular damage. We synthesized a series of cobalt-based hybrid molecules (HYCOs) that combine an Nrf2 inducer with a releaser of carbon monoxide (CO), an anti-inflammatory product of HO-1. Two HYCOs markedly increased Nrf2/HO-1 expression, liberated CO and exerted anti-inflammatory activity in vitro. HYCOs also up-regulated tissue HO-1 and delivered CO in blood after administration in vivo, supporting their potential use against inflammatory conditions.
authors.affiliation: Equipe 12, Inserm U955 , 8 Rue du Général Sarrail, Créteil, 94000, France.|Faculty of Medicine, University Paris Est Créteil , Créteil, 94000, France.
authors.forename: Aniket
authors.initials: A
authors.lastname: Nikam
authors.affiliation: ICMPE (UMR 7182), CNRS, UPEC, University Paris Est , F-94320 Thiais, France.
authors.forename: Anthony
authors.initials: A
authors.lastname: Ollivier
authors.affiliation: ICMPE (UMR 7182), CNRS, UPEC, University Paris Est , F-94320 Thiais, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Rivard
authors.affiliation: Equipe 12, Inserm U955 , 8 Rue du Général Sarrail, Créteil, 94000, France.|Faculty of Medicine, University Paris Est Créteil , Créteil, 94000, France.
authors.forename: Jayne Louise
authors.initials: JL
authors.lastname: Wilson
authors.affiliation: ICMPE (UMR 7182), CNRS, UPEC, University Paris Est , F-94320 Thiais, France.
authors.forename: Kevin
authors.initials: K
authors.lastname: Mebarki
authors.affiliation: ICMPE (UMR 7182), CNRS, UPEC, University Paris Est , F-94320 Thiais, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Martens
authors.affiliation: AP-HP, Henri Mondor Hospital, Service Hospitalier , Créteil, 94000, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Dubois-Randé
authors.affiliation: Equipe 12, Inserm U955 , 8 Rue du Général Sarrail, Créteil, 94000, France.|Faculty of Medicine, University Paris Est Créteil , Créteil, 94000, France.
authors.forename: Roberto
authors.initials: R
authors.lastname: Motterlini
authors.affiliation: Equipe 12, Inserm U955 , 8 Rue du Général Sarrail, Créteil, 94000, France.|Faculty of Medicine, University Paris Est Créteil , Créteil, 94000, France.
authors.forename: Roberta
authors.initials: R
authors.lastname: Foresti
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology; D002248:Carbon Monoxide / Q000097:blood / Q000737:chemistry / Q000378:metabolism*; D002263:Carboxyhemoglobin / Q000378:metabolism; D002460:Cell Line; D002470:Cell Survival; D003035:Cobalt / Q000737:chemistry*; D004789:Enzyme Activation / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D005978:Glutathione / Q000096:biosynthesis; D051547:Heme Oxygenase-1 / Q000096:biosynthesis / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051267:NF-E2-Related Factor 2 / Q000187:drug effects*; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D003035:Cobalt; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; D051547:Heme Oxygenase-1; D005978:Glutathione