title: Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7.
abstract: Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 3-5. Their structures were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were measured in vitro. Compound 4 exhibited potent activity against the U937 cell line with an IC50 value of 4.2 μM.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang 110122, China. xiaowangyu21@163.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory of Structure-Based Drug Design &amp; Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. lidahong0203@163.com.|School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. lidahong0203@163.com.
authors.forename: Da-Hong
authors.initials: DH
authors.lastname: Li
authors.affiliation: Key Laboratory of Structure-Based Drug Design &amp; Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. lzl1030@hotmail.com.|School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. lzl1030@hotmail.com.
authors.forename: Zhan-Lin
authors.initials: ZL
authors.lastname: Li
authors.affiliation: School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. sunyanjun2011@hactcm.edu.cn.
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Sun
authors.affiliation: Key Laboratory of Structure-Based Drug Design &amp; Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. huimhua@163.com.|School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. huimhua@163.com.
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Hua
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang 110122, China. taoliu0307@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.affiliation: Key Laboratory of Structure-Based Drug Design &amp; Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. baijiao@hotmail.com.|School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. baijiao@hotmail.com.
authors.forename: Jiao
authors.initials: J
authors.lastname: Bai
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020298:U937 Cells
chemical_list: D000970:Antineoplastic Agents; D013729:Terpenes
keywords: Aspergillus fumigatus; cell growth inhibition; marine-derived fungus; terpenoid