title: Continuum modeling of the electric-field-induced tension in deforming lipid vesicles.
abstract: We computationally investigate the deformation of a closed bilayer membrane (vesicle) in a DC electric pulse with a goal of understanding cell electroporation. The electric stresses exerted on the area-incompressible interface generate non-uniform tension that can exceed the membrane lysis tension and drive pore opening. Using the two-dimensional boundary integral method, we track the spatial and temporal evolution of the highest membrane tension. Our simulations highlight the dynamic nature of electrotension and, in contrast to the common assumption, a possibility of electroporation away from the poles.
authors.affiliation: Department of Mathematics and Statistics, University of New Mexico, Albuquerque, New Mexico 87131, USA.
authors.forename: Lane C
authors.initials: LC
authors.lastname: McConnell
authors.affiliation: Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, Illinois 60208, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Miksis
authors.affiliation: School of Engineering, Brown University, Providence, Rhode Island 02912, USA.
authors.forename: Petia M
authors.initials: PM
authors.lastname: Vlahovska
mesh_terms: D004574:Electromagnetic Fields; D018274:Electroporation; D057446:Hydrodynamics; D008051:Lipid Bilayers / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular
chemical_list: D008051:Lipid Bilayers