title: [Mechanisms of growth, development and disease of the craniofacial skeleton].
abstract: Craniofacial skeleton is derived from several pieces of bone, which hold the brain and house the sensory organ of vision, hearing, taste and smell. It also serves as an entrance of the digestive and respiratory tracts. Hence, craniofacial complex develops under sophisticated balance between the shape and the function. Disruption of such balance leads to various types of malformation and/or deformation of the face. This review focuses on the molecular aspects of growth and developments of the craniofacial structures and also on the genetic basis of congenital craniofacial malformations.
authors.affiliation: Department of Orthodontics and Dentofacial Orthopedics, Osaka University Graduate School of Dentistry, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamashiro
mesh_terms: D000818:Animals; D001848:Bone Diseases, Developmental / Q000235:genetics; D019465:Craniofacial Abnormalities / Q000235:genetics; D005147:Facial Bones / Q000254:growth & development; D055106:Genome-Wide Association Study; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics; D010750:Phosphoproteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics; D011986:Receptors, Somatotropin / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D012886:Skull / Q000254:growth & development; D051879:Twist-Related Protein 1 / Q000235:genetics
chemical_list: D018398:Homeodomain Proteins; C084119:MSX2 protein; D009687:Nuclear Proteins; D010750:Phosphoproteins; D011986:Receptors, Somatotropin; C105442:TCOF1 protein, human; C103173:TWIST1 protein, human; D051879:Twist-Related Protein 1; C496353:FGFR2 protein, human; D051497:Receptor, Fibroblast Growth Factor, Type 2