title: Peripheral blood leptin and resistin levels as clinical activity biomarkers in Mexican Rheumatoid Arthritis patients.
abstract: OBJECTIVE
  To evaluate the association between the clinical activity of RA patients and serum adipocytokines (Leptin, Adiponectin and Resistin) and inflammatory cytokines.
  
  
  METHODS
  All RA patients fulfilled ACR 1987 criteria and were treated with DMARDs. Adipocytokine and inflammatory cytokine levels were evaluated using ELISA.
  
  
  RESULTS
  121 patients were included in the study. Stratifying according to DAS28 (low, moderate and high activity), there were significant differences for Leptin, Resistin, IL-6 and IL-17, however, no differences were seen for Adiponectin, TNFα or IL-1β. Clinical activity positively correlated with Leptin, Resistin, IL-17 and IL-6 levels, but not with Adiponectin, TNFα or IL-1β. Adiponectin levels negatively correlated with TNFα and positively correlated with IL-1β. IL-1β positively correlated with IL-6 and negatively correlated with TNFα and IL-17.
  
  
  CONCLUSIONS
  Circulating Leptin, Resistin, IL-6 and IL-17 levels positively correlate with RA clinical activity in a manner independent of the subject's BMI. Complex relationships between inflammatory cytokines were observed in RA patients suggesting that other metabolic or inflammatory factors could be involved.
authors.affiliation: Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Mexico; Facultad de Ciencias, Universidad Autónoma del Estado de Morelos, Mexico.
authors.forename: Carolina
authors.initials: C
authors.lastname: Bustos Rivera-Bahena
authors.affiliation: Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Mexico; Hospital General de Cuernavaca "José G. Parres", SSM, Mexico.
authors.forename: Daniel-Xavier
authors.initials: DX
authors.lastname: Xibillé-Friedmann
authors.affiliation: Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Mexico.
authors.forename: Judith
authors.initials: J
authors.lastname: González-Christen
authors.affiliation: Hospital Regional 1°. Octubre, ISSSTE, D.F. Mexico, Mexico.
authors.forename: Sandra Miriam
authors.initials: SM
authors.lastname: Carrillo-Vázquez
authors.affiliation: Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Mexico. Electronic address: jlmontiel@uaem.mx.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Montiel-Hernández
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D052243:Resistin / Q000097:blood*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D018501:Antirheumatic Agents; D015415:Biomarkers; D016207:Cytokines; D020738:Leptin; C499624:RETN protein, human; D052243:Resistin
keywords: Actividad clínica; Adiponectin; Adiponectina; Artrtitis reumatoide; Citocinas pro-inflamatorias; Clinical activity; Leptin; Leptina; Pro-inflammatory cytokines; Resistin; Resistina; Rheumatoid arthritis