title: Parkinsonism in adult-onset Rasmussens's encephalitis: a clinical picture presenting as corticobasal syndrome.
abstract: Rasmussen's encephalitis (RE) is an immune-mediated disease, typically affecting a single cerebral hemisphere. Intractable epilepsy, hemiplegia and cognitive decline represent the clinical features; movement disorders have rarely been described. We report a case of adult-onset RE which developed hemiparkinsonism after an extraordinarily long prodromal period; to date, this is the first description of parkinsonism in RE. The association between cortical symptoms and extrapyramidal features evokes a clinical suspect of corticobasal syndrome (CBS); our patient satisfies the diagnostic criteria for possible CBS. Clinical and neuro-radiological reasons might further explain why RE accompanied by extrapyramidal signs may present as a CBS.
authors.affiliation: a Department of Neurosciences and Reproductive and Odontostomatological Sciences , Federico II University , Naples , Italy.
authors.forename: Leonilda
authors.initials: L
authors.lastname: Bilo
authors.affiliation: a Department of Neurosciences and Reproductive and Odontostomatological Sciences , Federico II University , Naples , Italy.
authors.forename: Silvio
authors.initials: S
authors.lastname: Peluso
authors.affiliation: a Department of Neurosciences and Reproductive and Odontostomatological Sciences , Federico II University , Naples , Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Antenora
authors.affiliation: a Department of Neurosciences and Reproductive and Odontostomatological Sciences , Federico II University , Naples , Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: De Rosa
authors.affiliation: a Department of Neurosciences and Reproductive and Odontostomatological Sciences , Federico II University , Naples , Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Esposito
authors.affiliation: a Department of Neurosciences and Reproductive and Odontostomatological Sciences , Federico II University , Naples , Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Barbato
authors.affiliation: b Biostructure and Bioimaging Institute , CNR , Naples , Italy.
authors.forename: Sabina
authors.initials: S
authors.lastname: Pappatà
authors.affiliation: a Department of Neurosciences and Reproductive and Odontostomatological Sciences , Federico II University , Naples , Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: De Michele
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D004660:Encephalitis / Q000150:complications* / Q000000981:diagnostic imaging; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging / Q000209:etiology*; D049268:Positron-Emission Tomography; D015898:Tomography Scanners, X-Ray Computed; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Rasmussen's encephalitis; corticobasal syndrome; dysimmune syndrome; parkinsonism