title: Characterization of the central sulcus in the brain in early childhood.
abstract: Characterization of the developing brain during early childhood is of interest for both neuroscience and medicine, and in particular, is key to understanding what goes wrong in neurodevelopmental disorders. In particular, the cortex grows rapidly in the first 3 years of life, and creating a normative atlas can provide a comparison tool to diagnose disorders at an early stage, thereby empowering early interventional therapies. Zooming in on specific sulci may provide additional targeted information, and notably, an understanding of central sulcus growth can provide important insight on the development of laterality. However, there currently do not exist any atlases of specific changes in sulci as the brain grows. In this pilot study, we explore regional differences in the depth of the central sulcus between two and three year old infants using brain magnetic resonance images.
authors.forename: Niharika
authors.initials: N
authors.lastname: Gajawelli
authors.forename: Sean
authors.initials: S
authors.lastname: Deoni
authors.forename: Holly
authors.initials: H
authors.lastname: Dirks
authors.forename: Douglas
authors.initials: D
authors.lastname: Dean
authors.forename: Jonathan
authors.initials: J
authors.lastname: O'Muircheartaigh
authors.forename: Siddhant
authors.initials: S
authors.lastname: Sawardekar
authors.forename: Andrea
authors.initials: A
authors.lastname: Ezis
authors.forename: Yalin
authors.initials: Y
authors.lastname: Wang
authors.forename: Marvin D
authors.initials: MD
authors.lastname: Nelson
authors.forename: Olivier
authors.initials: O
authors.lastname: Coulon
authors.forename: Natasha
authors.initials: N
authors.lastname: Lepore
mesh_terms: D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000254:growth & development*; D002675:Child, Preschool; D016208:Databases, Factual; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D059906:Neuroimaging / Q000379:methods; D010865:Pilot Projects