title: Hematopoietic stem cell transplantation for HIV cure.
abstract: The apparent cure of an HIV-infected person following hematopoietic stem cell transplantation (HSCT) from an allogeneic donor homozygous for the ccr5Δ32 mutation has stimulated the search for strategies to eradicate HIV or to induce long-term remission without requiring ongoing antiretroviral therapy. A variety of approaches, including allogeneic HSCT from CCR5-deficient donors and autologous transplantation of genetically modified hematopoietic stem cells, are currently under investigation. This Review covers the experience with HSCT in HIV infection to date and provides a survey of ongoing work in the field. The challenges of developing HSCT for HIV cure in the context of safe, effective, and convenient once-daily antiretroviral therapy are also discussed.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Kuritzkes
mesh_terms: D064591:Allografts; D064592:Autografts; D015658:HIV Infections / Q000235:genetics / Q000276:immunology / Q000628:therapy; D015497:HIV-1 / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D009154:Mutation; D019713:Receptors, CCR5 / Q000235:genetics / Q000276:immunology
chemical_list: C584933:CCR5 protein, human; D019713:Receptors, CCR5