title: Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma.
abstract: Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease.
authors.affiliation: Department of Surgery, Division of Pediatric Surgery, University of Alabama, Birmingham, AL 35233, USA. egarner@uabmc.edu.
authors.forename: Evan F
authors.initials: EF
authors.lastname: Garner
authors.affiliation: Department of Surgery, Division of Pediatric Surgery, University of Alabama, Birmingham, AL 35233, USA. elizabeth.beierle@childrensal.org.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Beierle
keywords: cancer stem cell; cancer-associated fibroblasts; hypoxia; neuroblastoma