title: RETINAL MANIFESTATIONS IN ADULT T-CELL LEUKEMIA/LYMPHOMA RELATED TO INFECTION BY THE HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-1.
abstract: OBJECTIVE
  To describe the retinal manifestations in adult T-cell leukemia (ATL) related to an infection by the human T-cell lymphotropic virus type-1 (HTLV-1).
  
  
  METHODS
  Retrospective case series of patients with ATL with retinal findings.
  
  
  RESULTS
  A total of 175 patients were diagnosed with ATL in Martinique between 1983 and 2013. Three of them showed intraocular findings related to ATL. They were bilateral deep retinal infiltrates associated with intermediate uveitis. In two cases, the ATL diagnosis was known. In the third, fluorescein angiography was remarkable for deep retinal infiltrates although fundus examination was unremarkable. The ATL cells were found in the blood of this patient. Despite chemotherapy, infiltrates progressed from the retinal periphery to the posterior pole in two patients, thus reducing visual acuity to light perception. They were associated with vasculitis.
  
  
  CONCLUSIONS
  Retinal involvement in ATL is very rare. It can occur at any point during the natural course of the disease. Human T-cell lymphotropic virus type-1 carriers should benefit from a regular ophthalmic examination, and a fluorescein angiography must be performed in all patients with human T-cell lymphotropic virus type-1 with vitreous cells. The presence of deep retinal infiltrates must raise suspicion for ATL in a patient with human T-cell lymphotropic virus type-1.
authors.affiliation: Departments of *Ophthalmology, †Hematology, and ‡Internal Medicine, Centre Hospitalier Universitaire de Martinique, Martinique, France.
authors.forename: Harold
authors.initials: H
authors.lastname: Merle
authors.forename: Rabih
authors.initials: R
authors.lastname: Hage
authors.forename: Jean-Côme
authors.initials: JC
authors.lastname: Meniane
authors.forename: Christophe
authors.initials: C
authors.lastname: Deligny
authors.forename: Yves
authors.initials: Y
authors.lastname: Plumelle
authors.forename: Angélique
authors.initials: A
authors.lastname: Donnio
authors.forename: Albert
authors.initials: A
authors.lastname: Jean-Charles
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015828:Eye Infections, Viral / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D017809:Fatal Outcome; D005260:Female; D005451:Fluorescein Angiography; D015490:HTLV-I Infections / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D008875:Middle Aged; D019572:Retinal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D012189:Retrospective Studies; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D016898:Interferon-alpha; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine