title: Recollection rejection of new items in individuals with first-episode psychosis.
abstract: Many objects seen for the first time look familiar because they resemble known objects. To overcome this feeling of familiarity and detect novelty, memories of known objects must be recollected and compared to new objects. This experiment examines whether recollection performed when perceiving new items (i.e., recollection rejection) is abnormal in people who experienced a first episode of psychosis (FEP). Recollection of old items is impaired in this clinical population but it has not yet been demonstrated that this impairment influences the processing of new items. Eighteen FEP participants and 19 healthy controls completed an episodic memory task consisting of a study phase and a recognition phase. All the new objects looked familiar because they resembled the studied objects. Brain activity underlying false recognition and correct rejection of new objects was measured with functional resonance magnetic imaging and compared across groups. Behavioral responses to new items were not significantly different between the 2 groups. However, the between-groups analysis revealed significant differences in brain activity in the left middle frontal gyrus, the left inferior parietal lobule, the right superior parietal lobule, and the right temporal fusiform gyrus during the correct rejection of new items. This activity seems related to recollection rejection and suggests that FEP patients do not normally recollect information of past events when they process new items.
authors.affiliation: Department of Psychology, McGill University.
authors.forename: Synthia
authors.initials: S
authors.lastname: Guimond
authors.affiliation: Department of Psychology, McGill University.
authors.forename: Martin
authors.initials: M
authors.lastname: Lepage
authors.affiliation: Douglas Mental Health University Institute.
authors.forename: Audrey
authors.initials: A
authors.lastname: Benoit
authors.affiliation: Center for Research in Neuropsychology and Cognition, University of Montreal.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Charbonneau
authors.affiliation: Department of Psychiatry, University of Toronto.
authors.forename: Colin
authors.initials: C
authors.lastname: Hawco
authors.affiliation: Douglas Mental Health University Institute.
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Malla
authors.affiliation: Douglas Mental Health University Institute.
authors.forename: Ridha
authors.initials: R
authors.lastname: Joober
authors.affiliation: Douglas Mental Health University Institute.
authors.forename: Mathieu B
authors.initials: MB
authors.lastname: Brodeur
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D061212:Memory, Episodic; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000523:psychology*; D021641:Recognition, Psychology / Q000502:physiology*; D055815:Young Adult