title: [Structure of poison xenobiotic based on results of toxicological analysis from Toxicological Laboratory in Krakow in years 2003 and 2013].
abstract: The aim of the study was to present changes in structure of toxicological analysis performed for hospitals in south-east Poland in last decennium. Material for the study were data from Toxicological Laboratory in Krakow in years 2003 and 2013. Total number of toxicological analysis decreased by about 30% in the period. The decline was related to analysis of ethanol, drugs of abuse (amphetamines, opiates, THC) and medicines. The number of determinations of acetylocholinoesterase activity (AChE)--marker of exposition to organophosphate and carbamate pesticides and carboxyhemoglobin (COHb)--marker of exposition to carbon monoxide also declined. The number of analysis of toxic alcohols (methanol and ethylene glycol) raised. The demand for determinations of new toxic substances (new drugs of abuse, "spices") appeared in the studied period. Advanced analytical methods (gas chromatography (GC), high performance liquid chromatography (HPLC), atomic absorption spectrometry (AAS) came into use in day-to-day routine. Changes in structure and numbers of determinations performed in regional toxicology laboratory reflects different trends. Prevalence of rapid tests for determination of drugs of abuse and alcohol in general medical laboratories caused decrease of number of the analysis in specialized toxicology laboratory. On the other hand growing demand for specialized analysis: new drugs of abuse, spices, new drugs, toxic alcohols and heavy metals was observed in last decennium.
authors.forename: Dorota
authors.initials: D
authors.lastname: Szpak
authors.forename: Ewa
authors.initials: E
authors.lastname: Gomółka
mesh_terms: D015415:Biomarkers / Q000032:analysis; D004781:Environmental Exposure / Q000032:analysis* / Q000706:statistics & numerical data*; D004784:Environmental Monitoring / Q000706:statistics & numerical data*; D000431:Ethanol / Q000032:analysis; D013287:Illicit Drugs / Q000032:analysis; D007753:Laboratories / Q000706:statistics & numerical data; D010575:Pesticides / Q000032:analysis; D011044:Poland; D015813:Substance Abuse Detection / Q000379:methods* / Q000706:statistics & numerical data*; D015262:Xenobiotics / Q000032:analysis* / Q000737:chemistry
chemical_list: D015415:Biomarkers; D013287:Illicit Drugs; D010575:Pesticides; D015262:Xenobiotics; D000431:Ethanol