title: Are itch and scratching the nausea and vomiting of skin?
abstract: The physiologic similarities between itch and nausea may not be evident initially, but they share the role of repelling irritants and toxins from the body by inducting scratching and vomiting, respectively. In addition, itch and nausea frequently occur together in certain conditions such as uraemia. Here we show that the mechanisms underlying itch and nausea overlap and that advances in either field may influence the identification of novel drug targets, particularly for itch.
authors.affiliation: Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.|Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.|Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Sattar
authors.initials: S
authors.lastname: Ostadhadi
authors.affiliation: Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Azimi
authors.affiliation: Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA.
authors.forename: Ethan A
authors.initials: EA
authors.lastname: Lerner
authors.affiliation: Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.|Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.|Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ahmad-Reza
authors.initials: AR
authors.lastname: Dehpour
mesh_terms: D000818:Animals; D006801:Humans; D009325:Nausea / Q000209:etiology* / Q000378:metabolism; D011537:Pruritus / Q000209:etiology* / Q000378:metabolism
keywords: itch; nausea; scratching; vomiting