title: Assessment of Gastric Emptying in Patients with Autoimmune Gastritis.
abstract: Symptoms of patients with autoimmune gastritis are not specific, and some patients may present symptoms suggestive of delayed gastric emptying. This study aims to investigate whether any delay in gastric emptying of solid food exists in patients with autoimmune gastritis and, if so, to identify the factors that might affect delayed gastric emptying.
  
  
  
  A total of 165 patients (106 women) diagnosed as having autoimmune gastritis were analyzed by means of a gastric emptying test. All patients underwent a standardized scintigraphic gastric emptying study. Patients with delayed gastric emptying and normal gastric emptying tests were then compared by means of factors that might affect gastric emptying. Also 65 patients with functional dyspepsia who had a gastric emptying study constituted the control group.
  
  
  
  The median gastric emptying T ½ time was 127.43 min (min-max 50-953) for patients with AIG and 81 min (min-max 21-121.6) for functional dyspepsia patients (p < 0.001), and median percent retention at 2 h was 63.8 versus 20.2 (p < 0.001). In multivariate analysis, parameters that affected gastric emptying T ½ time were found as serum gastrin level (OR 1.002, 95 % CI 1.001-1.004, p < 0.001, chronic inflammation (OR 3.689, 95 % CI 1.44-9.39, p < 0.001), and increase in the degree of the atrophy of the gastric mucosa (OR 8.96, 95 % CI 2.98-26.93, p < 0.001).
  
  
  
  In patients with autoimmune gastritis, gastric emptying is generally delayed. Autoimmune gastritis is an important etiology to explain the finding of delayed gastric emptying on a radionuclide test. This new finding is likely to be relevant to clinicians when evaluating and initiating appropriate medical treatment for patients with autoimmune gastritis manifesting upper gastrointestinal symptoms.
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Çağdaş
authors.initials: Ç
authors.lastname: Kalkan
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Ankara University, Ankara, Turkey. isoykan@medicine.ankara.edu.tr.
authors.forename: Irfan
authors.initials: I
authors.lastname: Soykan
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Çiğdem
authors.initials: Ç
authors.lastname: Soydal
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Elgin
authors.initials: E
authors.lastname: Özkan
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Emra
authors.initials: E
authors.lastname: Kalkan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000473:pathology*; D004415:Dyspepsia / Q000473:pathology; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D005756:Gastritis / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
keywords: Autoimmune gastritis; Gastric atrophy; Gastric emptying; Hypergastrinemia