title: Treatment Results of MammoSite Catheter in Combination with Whole-breast Irradiation.
abstract: OBJECTIVE
  To report the initial outcomes of patients treated with the MammoSite brachytherapy device (MSBT) as a boost followed by external whole-breast irradiation (WBI).
  
  
  METHODS
  From June 2011 to March 2014, 107 patients (typically with pT1-2, pN0-1, M0 disease) were treated with breast-conserving therapy and adjuvant radiotherapy with MSBT (15 Gy in 2.5-Gy fractions) followed by WBI (median=50.4 Gy). Toxicity was classified according to the Common Terminology Criteria for Adverse Events v3.0. The median follow-up was 21 months.
  
  
  RESULTS
  To date, no ipsilateral breast-tumor recurrences have been observed; 102 patients (95%) were alive at last follow-up. Two patients (2%) developed distant metastases. Five patients (5%) died during follow-up, only one as a result of breast cancer. The 2-year disease-free survival was 95±3%. The incidence of asymptomatic and symptomatic seroma in 90 days after MSBT was 28% and 10%, respectively. Infectious mastitis was observed in three patients (3%), who were treated successfully with antibiotics. Only three patients (3%) developed RT-induced dermatitis greater than grade 2 after WBI.
  
  
  CONCLUSIONS
  The boost technique used in this study seems to provide excellent local control with acceptable toxicity, similar to the results observed with other forms of interstitial accelerated partial-breast irradiation as a boost. Long-term follow-up is necessary to refine the patient selection criteria and to assess efficacy and late toxicities.
authors.affiliation: Department of Radiation Oncology, Marien Hospital Herne, Ruhr University Bochum, Bochum, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Gitt
authors.affiliation: Department of Radiation Oncology, Marien Hospital Herne, Ruhr University Bochum, Bochum, Germany.
authors.forename: Hugo
authors.initials: H
authors.lastname: Böse-Ribeiro
authors.affiliation: Department of Oncology and Palliative Medicine, Nordland Hospital Bodø, Bodø, Norway Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
authors.forename: Carsten
authors.initials: C
authors.lastname: Nieder
authors.affiliation: Department of Radiation Oncology, Marien Hospital Herne, Ruhr University Bochum, Bochum, Germany.
authors.forename: Philipp Günther
authors.initials: PG
authors.lastname: Kup
authors.affiliation: Department of Radiation Oncology, Marien Hospital Herne, Ruhr University Bochum, Bochum, Germany.
authors.forename: Horst
authors.initials: H
authors.lastname: Hermani
authors.affiliation: Department of Radiation Oncology, Marien Hospital Herne, Ruhr University Bochum, Bochum, Germany.
authors.forename: Helmut
authors.initials: H
authors.lastname: Bühler
authors.affiliation: Department of Senology, St. Anna Hospital Herne, Herne, Germany.
authors.forename: Hasan Yavuz
authors.initials: HY
authors.lastname: Ergönenç
authors.affiliation: Department of Senology, St. Anna Hospital Herne, Herne, Germany.
authors.forename: Dorothee
authors.initials: D
authors.lastname: Drüppel
authors.affiliation: Department of Radiation Oncology, Marien Hospital Herne, Ruhr University Bochum, Bochum, Germany Department of Radiation Oncology, Saint Josef Hospital Bochum, Ruhr University Bochum, Bochum, Germany.
authors.forename: Irenäus Anton
authors.initials: IA
authors.lastname: Adamietz
authors.affiliation: Department of Radiation Oncology, Marien Hospital Herne, Ruhr University Bochum, Bochum, Germany Department of Radiation Oncology, Saint Josef Hospital Bochum, Ruhr University Bochum, Bochum, Germany khfmed@yahoo.com.
authors.forename: Khashayar
authors.initials: K
authors.lastname: Fakhrian
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods*; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D016896:Treatment Outcome
keywords: Breast cancer; MammoSite; accelerated partial-breast irradiation; acute toxicity; boost radiotherapy