title: Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development.
abstract: Differential scanning calorimetry (DSC) is frequently the thermal analysis technique of choice within preformulation and formulation sciences because of its ability to provide detailed information about both the physical and energetic properties of a substance and/or formulation. However, conventional DSC has shortcomings with respect to weak transitions and overlapping events, which could be solved by the use of the more sophisticated modulated DSC (mDSC). mDSC has multiple potential applications within the pharmaceutical field and the present review provides an up-to-date overview of these applications. It is aimed to serve as a broad introduction to newcomers, and also as a valuable reference for those already practising in the field. Complex mDSC was introduced more than two decades ago and has been an important tool for the quantification of amorphous materials and development of freeze-dried formulations. However, as discussed in the present review, a number of other potential applications could also be relevant for the pharmaceutical scientist.
authors.affiliation: Pharmaceutical Science and CMC Biologics, H. Lundbeck A/S, 2500, Valby, Denmark; Institute of Pharmacy and Biochemistry, Johannes Gutenberg University of Mainz, 55128 Mainz, Germany.
authors.forename: Matthias Manne
authors.initials: MM
authors.lastname: Knopp
authors.affiliation: Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark.
authors.forename: Korbinian
authors.initials: K
authors.lastname: Löbmann
authors.affiliation: Platform Technology and Science, GlaxoSmithKline, SG12 0DP Hertfordshire, United Kingdom.
authors.forename: David P
authors.initials: DP
authors.lastname: Elder
authors.affiliation: Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Rades
authors.affiliation: Pharmaceutical Science and CMC Biologics, H. Lundbeck A/S, 2500, Valby, Denmark; Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark. Electronic address: rhol@lundbeck.com.
authors.forename: René
authors.initials: R
authors.lastname: Holm
mesh_terms: D002152:Calorimetry, Differential Scanning / Q000379:methods*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry*
chemical_list: D004364:Pharmaceutical Preparations
keywords: DSC; Drug development; Modulated differential scanning calorimetry; Pharmaceutical application; Thermal analysis