title: TLX-Its Emerging Role for Neurogenesis in Health and Disease.
abstract: The orphan nuclear receptor TLX, also called NR2E1, is a factor important in the regulation of neural stem cell (NSC) self-renewal, neurogenesis, and maintenance. As a transcription factor, TLX is vital for the expression of genes implicated in neurogenesis, such as DNA replication, cell cycle, adhesion and migration. It acts by way of repressing or activating target genes, as well as controlling protein-protein interactions. Growing evidence suggests that dysregulated TLX acts in the initiation and progression of human disorders of the nervous system. This review describes recent knowledge about TLX expression, structure, targets, and biological functions, relevant to maintaining adult neural stem cells related to both neuropsychiatric conditions and certain nervous system tumours.
authors.affiliation: Present address: Sree Chitra Tirunal Institute for Medical Sciences and Technology, Biomedical Technology Wing, Thiruvananthapuram, Kerala, 695 012, India.
authors.forename: Praveen K
authors.initials: PK
authors.lastname: Sobhan
authors.affiliation: Sahlgrenska Cancer Center, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, SE 40530, Gothenburg, Sweden. keiko.funa@gu.se.
authors.forename: Keiko
authors.identifier: http://orcid.org/0000-0003-2830-2273
authors.initials: K
authors.lastname: Funa
mesh_terms: D000818:Animals; D016543:Central Nervous System Neoplasms / Q000235:genetics / Q000378:metabolism; D006304:Health Status; D006801:Humans; D001523:Mental Disorders / Q000235:genetics / Q000378:metabolism; D058953:Neural Stem Cells / Q000737:chemistry / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*
chemical_list: C088601:NR2E1 protein, human; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear
keywords: Glioma; NR2E1; Nervous system tumours; Neural stem cells; Neuroblastoma; Neuropsychiatric disorders; Review; TLX