title: A new tigliane-type diterpene from Euphorbia dracunculoides Lam.
abstract: One new tigliane-type diterpene, 4-deoxy-4(β)H-8-hydroperoxyphorbol-12-benzoate-13-isobutyrate (1), together with two known diterpenoids, 3-acetyl-5,8-dibenzoyl-14α-propanoyl-13,17-epoxy-7-myrsinaone diterpene with C9-C10 cyclised to form an additional lactone ring (2), Euphodendriane A (3) have been isolated from the whole plants of Euphorbia dracunculoides Lam. Their structures were elucidated by means of extensive spectroscopic analysis (NMR and HR-ESI-MS) and comparison with data reported in the literature. This is the first isolation of 8-hydroperoxy tigliane diterpene (1) from the genus of Euphorbia. All compounds were evaluated for their antifungal activities.
authors.affiliation: a Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education , Southwest Forestry University , Kunming , P.R. China.
authors.forename: Lin-Feng
authors.initials: LF
authors.lastname: Dai
authors.affiliation: a Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education , Southwest Forestry University , Kunming , P.R. China.|b Department of Medicinal Plant, School of Forestry , Southwest Forestry University , Kunming , P.R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liang
authors.affiliation: a Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education , Southwest Forestry University , Kunming , P.R. China.
authors.forename: Tie
authors.initials: T
authors.lastname: Liu
authors.affiliation: a Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education , Southwest Forestry University , Kunming , P.R. China.
authors.forename: Ming-Yu
authors.initials: MY
authors.lastname: He
authors.affiliation: a Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education , Southwest Forestry University , Kunming , P.R. China.|b Department of Medicinal Plant, School of Forestry , Southwest Forestry University , Kunming , P.R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhao
authors.affiliation: a Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education , Southwest Forestry University , Kunming , P.R. China.
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Xu
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: C000617289:4-deoxy-4(beta)H-8-hydroperoxyphorbol-12-benzoate-13-isobutyrate; D000935:Antifungal Agents; D004224:Diterpenes
keywords: Euphorbia dracunculoides; diterpenoids; hydroperoxy; tigliane