title: Short Communication: Limited Anti-HIV-1 Activity of Maraviroc in Mucosal Tissues.
abstract: The potential of maraviroc (MVC), a small-molecule CCR5 antagonist, as a candidate to prevent HIV-1 sexual transmission by oral or topical dosing has not yet been completely established. Using relevant cellular and mucosal tissue explant models, we show partial antiviral activity of MVC when tested in multiple preclinical dosing strategies.
authors.affiliation: 1 Division of Cellular and Molecular Medicine, Centre for Infection, St. George's University of London , London, United Kingdom .
authors.forename: Patricia
authors.initials: P
authors.lastname: Fletcher
authors.affiliation: 1 Division of Cellular and Molecular Medicine, Centre for Infection, St. George's University of London , London, United Kingdom .
authors.forename: Carolina
authors.initials: C
authors.lastname: Herrera
authors.affiliation: 1 Division of Cellular and Molecular Medicine, Centre for Infection, St. George's University of London , London, United Kingdom .
authors.forename: Naomi
authors.initials: N
authors.lastname: Armanasco
authors.affiliation: 2 International Partnership for Microbicides, Silver Springs, Maryland.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Nuttall
authors.affiliation: 1 Division of Cellular and Molecular Medicine, Centre for Infection, St. George's University of London , London, United Kingdom .
authors.forename: Robin J
authors.initials: RJ
authors.lastname: Shattock
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002478:Cells, Cultured; D003510:Cyclohexanes / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D000077592:Maraviroc; D008954:Models, Biological; D009092:Mucous Membrane / Q000821:virology*; D009924:Organ Culture Techniques; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D003510:Cyclohexanes; D014230:Triazoles; D000077592:Maraviroc