title: Isolated Langerhans cell histiocytosis of the sublingual gland in an adult.
abstract: Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the proliferation of pathologic Langerhans cells. Its clinical presentation is highly variable, that range from single-system, limited disease to severe, multi-organ disease with high mortality. LCH usually affects children and young adults. The most frequent sites for LCH are the bone, skin, lung, pituitary gland, and lymph nodes. Salivary gland involvement by LCH is extremely rare, and only a few cases of LHC involving the parotid glands have been reported in the English literature. To our knowledge, the involvement of the sublingual gland as a part of single or multisystem LCH has not been previously described. Herein we reported the first case of primary LCH of the sublingual gland. A 40-year-old woman presented with a 2-month history of a painless mass on the right sublingual area. Excision of the lesion including the right sublingual gland was performed. Histopathological diagnosis of LCH was rendered. The patient remains free of symptoms 17 months after surgery.
authors.affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education Hubei, China ; Department of Pathology, School and Hospital of Stomatology, Wuhan University Wuhan, Hubei, China.
authors.forename: Shaodong
authors.initials: S
authors.lastname: Yang
authors.affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education Hubei, China ; Department of Pathology, School and Hospital of Stomatology, Wuhan University Wuhan, Hubei, China.
authors.forename: Xinming
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Pathology, School and Hospital of Stomatology, Wuhan University Wuhan, Hubei, China.
authors.forename: Jiali
authors.initials: J
authors.lastname: Zhang
authors.affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education Hubei, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Fang
mesh_terms: D000328:Adult; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D010306:Parotid Gland / Q000473:pathology; D012867:Skin / Q000473:pathology; D013361:Sublingual Gland / Q000473:pathology / Q000601:surgery
keywords: Langerhans cell histiocytosis; salivary gland; sublingual gland