title: Nonadherence to anti-HIV medication is associated with higher level of anxiety: Experience from a tertiary care hospital of Odisha.
abstract: OBJECTIVE
  To correlate the level of anxiety with nonadherence to antiretroviral medication.
  
  
  METHODS
  This observational, cross-sectional, hospital-based study was conducted in 78 patients attending antiretroviral therapy (ART) center of a tertiary care hospital of Odisha. The study duration was 6 months. Patients were designated as nonadherent by referring to the white card. Utilization of ART drugs and adverse drug reactions were included in a predesigned format. The anxiety level of all included patients was scored as per Hamilton Anxiety Rating Scale. Mean anxiety score of the adherent group was compared with that of the nonadherent group. Possible causes of nonadherence leading to high anxiety level were evaluated.
  
  
  RESULTS
  46% of patients in the nonadherent group had very severe, 17% had moderate to severe, 28% had mild to moderate and 9% had a mild level of anxiety. In the adherent group, however, mild to moderate level of anxiety was observed only in 10% patients.
  
  
  CONCLUSIONS
  Anxiety is associated with sub-optimal medication adherence in HIV infected patients.
authors.affiliation: Department of Pharmacology, SCB Medical College, Cuttack, Odisha, India.
authors.forename: Mousumee
authors.initials: M
authors.lastname: Panigrahi
authors.affiliation: Department of Pharmacology, SCB Medical College, Cuttack, Odisha, India.
authors.forename: Trupti Rekha
authors.initials: TR
authors.lastname: Swain
authors.affiliation: Department of Pharmacology, SCB Medical College, Cuttack, Odisha, India.
authors.forename: Srikanta
authors.initials: S
authors.lastname: Mohanty
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001007:Anxiety / Q000150:complications / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination / Q000009:adverse effects; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D062606:Tertiary Care Centers; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents
keywords: Adherence; Hamilton Anxiety Rating Scale; antiretroviral therapy; nonadherence