title: Copper-catalyzed asymmetric conjugate addition of organometallic reagents to extended Michael acceptors.
abstract: The copper-catalyzed asymmetric conjugate addition (ACA) of nucleophiles onto polyenic Michael acceptors represents an attractive and powerful methodology for the synthesis of relevant chiral molecules, as it enables in a straightforward manner the sequential generation of two or more stereogenic centers. In the last decade, various chiral copper-based catalysts were evaluated in combination with different nucleophiles and Michael acceptors, and have unambiguously demonstrated their usefulness in the control of the regio- and enantioselectivity of the addition. The aim of this review is to report recent breakthroughs achieved in this challenging field.
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, UMR CNRS 6226, 11 Allée de Beaulieu, 35708, Rennes cedex 7, France.
authors.forename: Thibault E
authors.initials: TE
authors.lastname: Schmid
authors.affiliation: Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-UM-ENSCM, Ecole Nationale Supérieure de Chimie, 8 Rue de l'Ecole Normale, 34296 Montpellier Cedex 5, France.
authors.forename: Sammy
authors.initials: S
authors.lastname: Drissi-Amraoui
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, UMR CNRS 6226, 11 Allée de Beaulieu, 35708, Rennes cedex 7, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Crévisy
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, UMR CNRS 6226, 11 Allée de Beaulieu, 35708, Rennes cedex 7, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Baslé
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, UMR CNRS 6226, 11 Allée de Beaulieu, 35708, Rennes cedex 7, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Mauduit
keywords: conjugate additions; electron-deficient alkenes; enantioselective catalysis; extended Michael acceptors; organometallic nucleophiles; sequential addition