title: Action of AlGaInP laser and high frequency generator in cutaneous wound healing. A comparative study.
abstract: OBJECTIVE
  To evaluate in a macroscopic, histological and histomorphometric manner the healing process of cutaneous wounds in mice.
  
  
  METHODS
  The sample consisted of 40 male mice and was divided in four groups: 1st group (control, n=10), 2nd group (High Frequency Generator - HF, the maximum amplitude range, 120s, n=10), 3rd group (AlGaInP Laser 660 nm, 30mW power, 5 J/cm2, applying scan mode, 120s, n=10) and 4thgroup (AlGaInP Laser 660 nm, 30 mW power, 8 J/cm2, applying scan mode, n=10). The surgical incision was made with an 8 mm diameter punch perpendicularly to the back of the animal. The statistical analysis was achieved by the statistical test One Way Anova post hoc Tukey Test and significance at p<0.05 in GraphPad Prism program.
  
  
  RESULTS
  It was observed that in the acute phase the AlGaInP Laser at 5 J/cm2 provided a greater stimulus to healing, and both lasers were effective in the remodeling phase.
  
  
  CONCLUSIONS
  The AlGaInP lasers from 5 J/cm2 to 8 J/cm2 showed better biomodulatory results in the acute and remodeling phases respectively, however, the HF was less effective than the laser, providing significant benefits only in the acute phase of tissue repair.
authors.affiliation: Instituto Federal de Educação, Ciências e Tecnologia, Teresina, PI, Brazil.
authors.forename: Rayssilane Cardoso de
authors.initials: RC
authors.lastname: Sousa
authors.affiliation: Universidade do Vale do Paraíba, Sao Jose dos Campos, SP, Brazil.
authors.forename: Antônio Luiz Martins
authors.initials: AL
authors.lastname: Maia Filho
authors.affiliation: Institute for Research and Development, UNIVAP, Sao Jose dos Campos, SP, Brazil.
authors.forename: Renata Amadei
authors.initials: RA
authors.lastname: Nicolau
authors.affiliation: Universidade Federal do Piauí, Teresina, PI, Brazil.
authors.forename: Lianna Martha Soares
authors.initials: LM
authors.lastname: Mendes
authors.affiliation: Universidade Presbiteriana Mackenzie, Sao Paulo, SP, Brazil.
authors.forename: Talvany Luis de
authors.initials: TL
authors.lastname: Barros
authors.affiliation: UNIVAP, Sao Jose dos Campos, SP, Brazil.
authors.forename: Silvana Maria Véras
authors.initials: SM
authors.lastname: Neves
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D005347:Fibroblasts / Q000473:pathology / Q000528:radiation effects; D007249:Inflammation / Q000473:pathology / Q000532:radiotherapy; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D051379:Mice; D023421:Models, Animal; D010126:Ozone / Q000627:therapeutic use; D011829:Radiation Dosage; D011897:Random Allocation; D012867:Skin / Q000293:injuries* / Q000473:pathology / Q000528:radiation effects; D013997:Time Factors; D014945:Wound Healing / Q000528:radiation effects*
chemical_list: D010126:Ozone