title: Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma.
abstract: Magnetic particles that can be precisely controlled under a magnetic field and transduce energy from the applied field open the way for innovative cancer treatment. Although these particles represent an area of active development for drug delivery and magnetic hyperthermia, the in vivo anti-tumor effect under a low-frequency magnetic field using magnetic particles has not yet been demonstrated. To-date, induced cancer cell death via the oscillation of nanoparticles under a low-frequency magnetic field has only been observed in vitro. In this report, we demonstrate the successful use of spin-vortex, disk-shaped permalloy magnetic particles in a low-frequency, rotating magnetic field for the in vitro and in vivo destruction of glioma cells. The internalized nanomagnets align themselves to the plane of the rotating magnetic field, creating a strong mechanical force which damages the cancer cell structure inducing programmed cell death. In vivo, the magnetic field treatment successfully reduces brain tumor size and increases the survival rate of mice bearing intracranial glioma xenografts, without adverse side effects. This study demonstrates a novel approach of controlling magnetic particles for treating malignant glioma that should be applicable to treat a wide range of cancers.
authors.affiliation: Shanghai East Hospital, The Institute for Biomedical Engineering and Nano Science, Tongji University School of Medicine, Shanghai, China; The Brain Tumor Center, The University of Chicago, Chicago, IL 60637, United States.
authors.forename: Yu
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, United States.
authors.forename: Megan E
authors.initials: ME
authors.lastname: Muroski
authors.affiliation: Thin Film Magnetism Group, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom.
authors.forename: Dorothée C M C
authors.initials: DCMC
authors.lastname: Petit
authors.affiliation: Thin Film Magnetism Group, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom.
authors.forename: Rhodri
authors.initials: R
authors.lastname: Mansell
authors.affiliation: Thin Film Magnetism Group, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom.
authors.forename: Tarun
authors.initials: T
authors.lastname: Vemulkar
authors.affiliation: The Brain Tumor Center, The University of Chicago, Chicago, IL 60637, United States.
authors.forename: Ramin A
authors.initials: RA
authors.lastname: Morshed
authors.affiliation: Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, United States.
authors.forename: Yu
authors.initials: Y
authors.lastname: Han
authors.affiliation: Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, United States.
authors.forename: Irina V
authors.initials: IV
authors.lastname: Balyasnikova
authors.affiliation: Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, United States.
authors.forename: Craig M
authors.initials: CM
authors.lastname: Horbinski
authors.affiliation: The Brain Tumor Center, The University of Chicago, Chicago, IL 60637, United States.
authors.forename: Xinlei
authors.initials: X
authors.lastname: Huang
authors.affiliation: The Brain Tumor Center, The University of Chicago, Chicago, IL 60637, United States.
authors.forename: Lingjiao
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Thin Film Magnetism Group, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom.
authors.forename: Russell P
authors.initials: RP
authors.lastname: Cowburn
authors.affiliation: Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, United States. Electronic address: maciej.lesniak@northwestern.edu.
authors.forename: Maciej S
authors.initials: MS
authors.lastname: Lesniak
mesh_terms: D000818:Animals; D017209:Apoptosis; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D005910:Glioma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D060526:Magnetic Fields; D008297:Male; D051379:Mice; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000008:administration & dosage* / Q000627:therapeutic use; D014018:Tissue Distribution; D047368:Tumor Burden
keywords: Magnetic field; Magnetic particles; Malignant glioma; Mechanical destruction