title: Primary thyroid spindle cell tumors: spindle cell variant of papillary thyroid carcinoma?
abstract: Primary thyroid spindle cell tumors or spindle cell component in the thyroid tumors are very rare. The spindle tumor cells were positive for thyroid papillary carcinoma markers. So these tumors were diagnosed as spindle cell variant of papillary thyroid carcinoma (PTC). To further delineate clinico-pathological features of primary thyroid spindle cell tumors and discuss differential diagnosis, we reported a 67-year-old man with a mass in the right thyroid without clinical symptom. Microscopy revealed that an encapsulated tumor with lot criss spindle cells arranged in bundles. Nuclear grooves were easy to see and rare displayed pseudoinclusions. Immunohistochemical studied showed that the spindle cells were all strong positive for TTF-1, Pax-8, thyroglobulin. Rare follicular were seen in the periphery of the tumor near the thyroid tissue. The cells formed follicular but the spindle tumor cells were positive for pan-keratins. The pathological diagnosis was primary thyroid spindle cell tumors, suspected spindle cell variant of PTC. Primary thyroid spindle cell tumors were presence and without the unified name. The further reports and more discussion were need about these tumors.
authors.affiliation: Department of Pathology, Changzheng Hospital, Second Military Medical University Shanghai, China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Pathology, Changzheng Hospital, Second Military Medical University Shanghai, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Xia
authors.affiliation: Department of Pathology, Changzheng Hospital, Second Military Medical University Shanghai, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Pathology, Changzheng Hospital, Second Military Medical University Shanghai, China.
authors.forename: Weijian
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D008297:Male; D000072636:PAX8 Transcription Factor; D051761:Paired Box Transcription Factors / Q000378:metabolism; D013954:Thyroglobulin / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D014157:Transcription Factors; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D000072636:PAX8 Transcription Factor; C083325:PAX8 protein, human; D051761:Paired Box Transcription Factors; C504003:TTF1 protein, human; D014157:Transcription Factors; D013954:Thyroglobulin
keywords: Spindle cells; thyroid; tumor