title: Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects.
abstract: The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an atypical anatomical pattern of the hippocampus, which has been reported in healthy subjects in different studies. However, extensive characterization of IHI in a large sample has not yet been performed. Furthermore, it is unclear whether IHI are restricted to the medial-temporal lobe or are associated with more extensive anatomical changes. Here, we studied the characteristics of IHI in a community-based sample of 2008 subjects of the IMAGEN database and their association with extra-hippocampal anatomical variations. The presence of IHI was assessed on T1-weighted anatomical magnetic resonance imaging (MRI) using visual criteria. We assessed the association of IHI with other anatomical changes throughout the brain using automatic morphometry of cortical sulci. We found that IHI were much more frequent in the left hippocampus (left: 17%, right: 6%, χ(2)-test, p < 10(-28)). Compared to subjects without IHI, subjects with IHI displayed morphological changes in several sulci located mainly in the limbic lobe. Our results demonstrate that IHI are a common left-sided phenomenon in normal subjects and that they are associated with morphological changes outside the medial temporal lobe.
authors.affiliation: Institut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du Cerveau et de la Moelle épinière, Institut du Cerveau et de la Moelle épinièreParis, France; Inria, Aramis Team, Centre de Recherche Paris-RocquencourtParis, France; Centre d'Acquisition et de Traitement des ImagesParis, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Cury
authors.affiliation: Centre National de la Recherche Scientifique, Genes, Synapses and Cognition, URA 2182, Institut PasteurParis, France; Human Genetics and Cognitive Functions, Institut PasteurParis, France.
authors.forename: Roberto
authors.initials: R
authors.lastname: Toro
authors.affiliation: Institut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du Cerveau et de la Moelle épinière, Institut du Cerveau et de la Moelle épinièreParis, France; Inria, Aramis Team, Centre de Recherche Paris-RocquencourtParis, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Cohen
authors.affiliation: Centre d'Acquisition et de Traitement des ImagesParis, France; Institut d'Imagerie Biomédicale; Commissariat à l'énergie atomique et aux énergies alternatives; Direction des Sciences du VivantGif-Sur-Yvette, France.
authors.forename: Clara
authors.initials: C
authors.lastname: Fischer
authors.affiliation: Institut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du Cerveau et de la Moelle épinière, Institut du Cerveau et de la Moelle épinièreParis, France; Inria, Aramis Team, Centre de Recherche Paris-RocquencourtParis, France.
authors.forename: Amel
authors.initials: A
authors.lastname: Mhaya
authors.affiliation: Institut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du Cerveau et de la Moelle épinière, Institut du Cerveau et de la Moelle épinièreParis, France; Inria, Aramis Team, Centre de Recherche Paris-RocquencourtParis, France.
authors.forename: Jorge
authors.initials: J
authors.lastname: Samper-González
authors.affiliation: Institut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du Cerveau et de la Moelle épinière, Institut du Cerveau et de la Moelle épinièreParis, France; Inria, Aramis Team, Centre de Recherche Paris-RocquencourtParis, France; Departments of Neuroradiology and Neurology, AP-HP, Hôpital de la Pitié-SalpétrièreParis, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Hasboun
authors.affiliation: Centre d'Acquisition et de Traitement des ImagesParis, France; Institut d'Imagerie Biomédicale; Commissariat à l'énergie atomique et aux énergies alternatives; Direction des Sciences du VivantGif-Sur-Yvette, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mangin
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, Clinical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg Mannheim, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Banaschewski
authors.affiliation: Discipline of Psychiatry, School of Medicine, Trinity College DublinDublin, Ireland; Institute of Neuroscience, Trinity College DublinDublin, Ireland.
authors.forename: Arun L W
authors.initials: AL
authors.lastname: Bokde
authors.affiliation: Department of Systems Neuroscience, Universitätsklinikum Hamburg Eppendorf Hamburg, Germany.
authors.forename: Uli
authors.initials: U
authors.lastname: Bromberg
authors.affiliation: Department of Systems Neuroscience, Universitätsklinikum Hamburg EppendorfHamburg, Germany; Department of Psychology, Stanford UniversityStanford, CA, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Buechel
authors.affiliation: Institute of Psychiatry, Psychology and Neuroscience, King's College LondonLondon, UK; MRC Social, Genetic and Developmental Psychiatry CentreLondon, UK.
authors.forename: Anna
authors.initials: A
authors.lastname: Cattrell
authors.affiliation: Institute of Psychiatry, Psychology and Neuroscience, King's College LondonLondon, UK; Département de Psychiatrie, Centre Hospitalier Universitaire Sainte-Justine, Université de MontrealMontreal, QC, Canada.
authors.forename: Patricia
authors.initials: P
authors.lastname: Conrod
authors.affiliation: Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University Mannheim, Germany.
authors.forename: Herta
authors.initials: H
authors.lastname: Flor
authors.affiliation: Department of Systems Neuroscience, Universitätsklinikum Hamburg EppendorfHamburg, Germany; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin BerlinGermany.
authors.forename: Juergen
authors.initials: J
authors.lastname: Gallinat
authors.affiliation: Discipline of Psychiatry, School of Medicine, Trinity College Dublin Dublin, Ireland.
authors.forename: Hugh
authors.initials: H
authors.lastname: Garavan
authors.affiliation: School of Physics and Astronomy, University of Nottingham Nottingham, UK.
authors.forename: Penny
authors.initials: P
authors.lastname: Gowland
authors.affiliation: Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Heinz
authors.affiliation: Physikalisch-Technische Bundesanstalt Berlin, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Ittermann
authors.affiliation: Institut national de la santé et de la recherche médicale U1000, Neuroimagerie en Psychiatrie, Université Paris-Sud, Université Paris Descartes Paris, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Lemaitre
authors.affiliation: Institut national de la santé et de la recherche médicale U1000, Neuroimagerie en Psychiatrie, Université Paris-Sud, Université Paris Descartes Paris, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Martinot
authors.affiliation: Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University Mannheim, Germany.
authors.forename: Frauke
authors.initials: F
authors.lastname: Nees
authors.affiliation: Institut national de la santé et de la recherche médicale U1000, Neuroimagerie en Psychiatrie, Université Paris-Sud, Université Paris DescartesParis, France; AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, University Paris Descartes, Sorbonne Paris CitéParis, France.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Paillère Martinot
authors.affiliation: Institut d'Imagerie Biomédicale; Commissariat à l'énergie atomique et aux énergies alternatives; Direction des Sciences du Vivant Gif-Sur-Yvette, France.
authors.forename: Dimitri P
authors.initials: DP
authors.lastname: Orfanos
authors.affiliation: Rotman Research Institute, BaycrestToronto, ON, Canada; Departments of Psychology and Psychiatry, University of TorontoToronto, Canada; Center for Developing Brain, Child Mind InstituteNew York, NY, USA.
authors.forename: Tomas
authors.initials: T
authors.lastname: Paus
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, Clinical Faculty Mannheim, Central Institute of Mental Health, University of HeidelbergMannheim, Germany; Department of Child and Adolescent Psychiatry, Medical University of ViennaVienna, Austria.
authors.forename: Luise
authors.initials: L
authors.lastname: Poustka
authors.affiliation: Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden Dresden, Germany.
authors.forename: Michael N
authors.initials: MN
authors.lastname: Smolka
authors.affiliation: Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin BerlinGermany; Berlin School of Mind and Brain, Humboldt University BerlinBerlin, Germany.
authors.forename: Henrik
authors.initials: H
authors.lastname: Walter
authors.affiliation: Department of Psychology, University College Dublin Dublin, Ireland.
authors.forename: Robert
authors.initials: R
authors.lastname: Whelan
authors.affiliation: Institut d'Imagerie Biomédicale; Commissariat à l'énergie atomique et aux énergies alternatives; Direction des Sciences du Vivant Gif-Sur-Yvette, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Frouin
authors.affiliation: Institute of Psychiatry, Psychology and Neuroscience, King's College LondonLondon, UK; MRC Social, Genetic and Developmental Psychiatry CentreLondon, UK.
authors.forename: Gunter
authors.initials: G
authors.lastname: Schumann
authors.affiliation: MAP5, Université Paris Descartes, Sorbonne Paris Cité Paris, France.
authors.forename: Joan A
authors.initials: JA
authors.lastname: Glaunès
authors.affiliation: Institut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du Cerveau et de la Moelle épinière, Institut du Cerveau et de la Moelle épinièreParis, France; Inria, Aramis Team, Centre de Recherche Paris-RocquencourtParis, France; Centre d'Acquisition et de Traitement des ImagesParis, France; Departments of Neuroradiology and Neurology, AP-HP, Hôpital de la Pitié-SalpétrièreParis, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Colliot
keywords: IMAGEN database; Large database; MRI; anatomical variability; brain development; cortical sulci; human hippocampus; malrotation