title: Development of an experimental model of neurocysticercosis-induced hydrocephalus. Pilot study.
abstract: OBJECTIVE
  To develop an experimental model of neurocysticercosis-induced hydrocephalus
  
  
  METHODS
  There were used 17 rats. Ten animals were inoculated with Taenia crassiceps cysts into the subarachnoid. Five animals were injected with 0. ml of 25% kaolin (a standard solution for the development of experimental hydrocephalus) and two animals were injected with saline. Magnetic resonance imaging (MRI) was used to evaluate enlargement of the ventricles after one or three months of inoculation. Volumetric study was used to quantify the ventricle enlargement.
  
  
  RESULTS
  Seven of the 10 animals in the cyst group developed hydrocephalus, two of them within one month and five within three months after inoculation. Three of the five animals in the kaolin group had hydrocephalus and none in the saline group. Ventricle volumes were significantly higher in the 3-months MRI cyst subgroup than in the 1-month cyst subgroup. Differences between cyst subgroups and kaolin group did not reach statistical significance.
  
  
  CONCLUSIONS
  The developed model may reproduce the human condition of neurocysticercosis-related hydrocephalus, which exhibits a slowly progressive chronic course.
authors.affiliation: Botucatu Medical School, Universidade Estadual Paulista, Botucatu, SP, Brazil.
authors.forename: Pedro Tadao
authors.initials: PT
authors.lastname: Hamamoto Filho
authors.affiliation: Department of Neurology, Psychology and Psychiatry, Botucatu Medical School, UNESP, Botucatu, SP, Brazil.
authors.forename: Marco Antônio
authors.initials: MA
authors.lastname: Zanini
authors.affiliation: Botucatu Medical School, UNESP, Botucatu, SP, Brazil.
authors.forename: Fabio Pires
authors.initials: FP
authors.lastname: Botta
authors.affiliation: Department of Microbiology and Immunology, Institute of Biosciences, UNESP, Botucatu, SP, Brazil.
authors.forename: Marianna Vaz
authors.initials: MV
authors.lastname: Rodrigues
authors.affiliation: Department of Neurology, Psychology and Psychiatry, Botucatu Medical School, UNESP, Botucatu, SP, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Bazan
authors.affiliation: Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, UNESP, Botucatu, SP, Brazil.
authors.forename: Luiz Carlos
authors.initials: LC
authors.lastname: Vulcano
authors.affiliation: Department of Veterinary Hygiene ad Public Health, School of Veterinary Medicine and Animal Science, UNESP, Botucatu, SP, Brazil.
authors.forename: Germano Francisco
authors.initials: GF
authors.lastname: Biondi
mesh_terms: D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000473:pathology; D004195:Disease Models, Animal; D006849:Hydrocephalus / Q000139:chemically induced*; D007616:Kaolin; D008279:Magnetic Resonance Imaging; D020019:Neurocysticercosis / Q000469:parasitology* / Q000473:pathology; D010865:Pilot Projects; D017208:Rats, Wistar; D013621:Taenia
chemical_list: D007616:Kaolin