title: CD56 and RUNX1 isoforms in AML prognosis and their therapeutic potential.
abstract: Neural cell adhesion molecule (NCAM/CD56) expression in acute myeloid leukemia (AML) has been associated with extramedullary leukemia, multidrug resistance, shorter remission and survival. Recently, Bloomfield et al. published a succinct review of issues surrounding the AML prognostication and current therapeutics. However, we want to reiterate the prognostic value and therapeutic potential of CD56 that is frequently expressed in AML as was also reported by their own group earlier. In addition, novel RUNX1 isoforms contribute in controlling CD56 expression in AML cells. Anti-CD56 antibody therapy deserves exploration as an arsenal against AML patients expressing CD56. Relevantly, targeting RNA splicing machinery or RUNX1 isoform-specific siRNA may also become part of future therapeutic strategies for AML with CD56 overexpression.
authors.affiliation: Department of Adult Hematology/BMT, King Fahad Medical City, Riyadh, Saudi Arabia; Faculty of Medicine, King Saud Bin Abdulaziz University of Health Sciences, Riyadh, Saudi Arabia. Electronic address: szazaidi@hotmail.com.
authors.forename: Syed Z A
authors.initials: SZ
authors.lastname: Zaidi
authors.affiliation: Department of Adult Hematology/BMT, King Fahad Medical City, Riyadh, Saudi Arabia; Faculty of Medicine, King Saud Bin Abdulaziz University of Health Sciences, Riyadh, Saudi Arabia.
authors.forename: Ibraheem H
authors.initials: IH
authors.lastname: Motabi
authors.affiliation: National Blood and Cancer Center, Riyadh, Saudi Arabia; King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
authors.forename: Ali
authors.initials: A
authors.lastname: Al-Shanqeeti
mesh_terms: D019002:CD56 Antigen / Q000378:metabolism*; D050676:Core Binding Factor Alpha 2 Subunit / Q000378:metabolism*; D018572:Disease-Free Survival; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D011379:Prognosis; D020033:Protein Isoforms / Q000378:metabolism
chemical_list: D019002:CD56 Antigen; D050676:Core Binding Factor Alpha 2 Subunit; D020033:Protein Isoforms; C493728:RUNX1 protein, human
keywords: AML; Anti-CD56 antibody; CD56; NCAM; Prognosis; RUNX1