title: Genetic Structure of a Local Population of the Anopheles gambiae Complex in Burkina Faso.
abstract: Members of the Anopheles gambiae species complex are primary vectors of human malaria in Africa. Population heterogeneities for ecological and behavioral attributes expand and stabilize malaria transmission over space and time, and populations may change in response to vector control, urbanization and other factors. There is a need for approaches to comprehensively describe the structure and characteristics of a sympatric local mosquito population, because incomplete knowledge of vector population composition may hinder control efforts. To this end, we used a genome-wide custom SNP typing array to analyze a population collection from a single geographic region in West Africa. The combination of sample depth (n = 456) and marker density (n = 1536) unambiguously resolved population subgroups, which were also compared for their relative susceptibility to natural genotypes of Plasmodium falciparum malaria. The population subgroups display fluctuating patterns of differentiation or sharing across the genome. Analysis of linkage disequilibrium identified 19 new candidate genes for association with underlying population divergence between sister taxa, A. coluzzii (M-form) and A. gambiae (S-form).
authors.affiliation: Program in Genomics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, 02115, United States of America.
authors.forename: Kyriacos
authors.initials: K
authors.lastname: Markianos
authors.affiliation: Institut Pasteur, Unit of Insect Vector Genetics and Genomics, Department of Parasites and Insect Vectors, CNRS Unit of Hosts, Vectors and Pathogens (URA3012), Paris, 75015, France.|CNRS, Unit of Hosts, Vectors and Pathogens (URA3012), 28 rue du Docteur Roux, Paris, 75015, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bischoff
authors.affiliation: Institut Pasteur, Unit of Insect Vector Genetics and Genomics, Department of Parasites and Insect Vectors, CNRS Unit of Hosts, Vectors and Pathogens (URA3012), Paris, 75015, France.|CNRS, Unit of Hosts, Vectors and Pathogens (URA3012), 28 rue du Docteur Roux, Paris, 75015, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Mitri
authors.affiliation: Centre National de Recherche et de Formation sur le Paludisme, 01 BP 2208 Ouagadougou, Burkina Faso.
authors.forename: Wamdaogo M
authors.initials: WM
authors.lastname: Guelbeogo
authors.affiliation: Centre National de Recherche et de Formation sur le Paludisme, 01 BP 2208 Ouagadougou, Burkina Faso.
authors.forename: Awa
authors.initials: A
authors.lastname: Gneme
authors.affiliation: Institut Pasteur, Unit of Insect Vector Genetics and Genomics, Department of Parasites and Insect Vectors, CNRS Unit of Hosts, Vectors and Pathogens (URA3012), Paris, 75015, France.|CNRS, Unit of Hosts, Vectors and Pathogens (URA3012), 28 rue du Docteur Roux, Paris, 75015, France.
authors.forename: Karin
authors.initials: K
authors.lastname: Eiglmeier
authors.affiliation: Institut Pasteur, Unit of Insect Vector Genetics and Genomics, Department of Parasites and Insect Vectors, CNRS Unit of Hosts, Vectors and Pathogens (URA3012), Paris, 75015, France.|CNRS, Unit of Hosts, Vectors and Pathogens (URA3012), 28 rue du Docteur Roux, Paris, 75015, France.
authors.forename: Inge
authors.initials: I
authors.lastname: Holm
authors.affiliation: Centre National de Recherche et de Formation sur le Paludisme, 01 BP 2208 Ouagadougou, Burkina Faso.
authors.forename: N'Fale
authors.initials: N
authors.lastname: Sagnon
authors.affiliation: Institut Pasteur, Unit of Insect Vector Genetics and Genomics, Department of Parasites and Insect Vectors, CNRS Unit of Hosts, Vectors and Pathogens (URA3012), Paris, 75015, France.|CNRS, Unit of Hosts, Vectors and Pathogens (URA3012), 28 rue du Docteur Roux, Paris, 75015, France.|University of Minnesota, Department of Microbiology, Saint Paul, Minnesota, 55108, United States of America.
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Vernick
authors.affiliation: University of Minnesota, Department of Microbiology, Saint Paul, Minnesota, 55108, United States of America.
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Riehle
mesh_terms: D000818:Animals; D000852:Anopheles / Q000145:classification / Q000235:genetics*; D002050:Burkina Faso / Q000453:epidemiology; D040342:Genetic Structures; D005828:Genetics, Population / Q000379:methods; D049750:Genome, Insect / Q000235:genetics*; D005838:Genotype; D005843:Geography; D006801:Humans; D007303:Insect Vectors / Q000145:classification / Q000235:genetics*; D015810:Linkage Disequilibrium; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000469:parasitology; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D011157:Population Dynamics; D013045:Species Specificity