title: A Comparison of Nephrotoxicity of Contrast Medium in Elderly Patients who Underwent Renal or Peripheral Arterial Vascular Intervention.
abstract: OBJECTIVE
  To compare the nephrotoxicity of iodixanol in elderly patients who underwent a renal artery intervention (RAI) with those who underwent an other peripheral vascular intervention (OPI).
  
  
  METHODS
  Three hundred fifty-four consecutive patients (>60 years old) received iodixanol during RAI (n=150) or OPI (n=204). The level of serum creatinine (SCr) was measured at the baseline, 24 hours, 48 hours, 72 hours and 1 month after intervention.
  
  
  RESULTS
  Within 72 hours after the intervention, the adjusted mean of the peak SCr increase was 11.22 umol/L 〔95% confidence interval (CI): 9.21-13.24〕 in the RAI group and 12.40 umol/L (95%CI: 10.7-14.09) in the OPI group. The difference in the peak SCr increase was -1.17 umol/L (95%CI: -3.94-1.60; p=0.406). Contrast-induced nephropathy occurred in 26 patients (17.3%) of the RAI group and in 27 patients (13.2%) of the OPI group (p=0.286). Patients who underwent an RAI showed no increased risk for contrast-induced nephropathy in comparison with patients who underwent an OPI 〔adjusted odds ratio (OR)=1.108; 95%CI: 0.540-2.273; p=0.780〕.
  
  
  CONCLUSIONS
  The nephrotoxic effect of iodixanol in elderly patients who underwent RAI or OPI was comparable.
authors.affiliation: Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Peng
authors.forename: Xiong-jing
authors.initials: XJ
authors.lastname: Jiang
authors.forename: Hui
authors.initials: H
authors.lastname: Dong
authors.forename: Yu-bao
authors.initials: YB
authors.lastname: Zou
authors.forename: Lei
authors.initials: L
authors.lastname: Song
authors.forename: Hui-min
authors.initials: HM
authors.lastname: Zhang
authors.forename: Hai-ying
authors.initials: HY
authors.lastname: Wu
authors.forename: Yue-jin
authors.initials: YJ
authors.lastname: Yang
authors.forename: Run-lin
authors.initials: RL
authors.lastname: Gao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000601:surgery*; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects* / Q000633:toxicity; D017023:Coronary Angiography; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D011446:Prospective Studies; D012077:Renal Artery; D051437:Renal Insufficiency / Q000139:chemically induced*; D012307:Risk Factors; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000009:adverse effects* / Q000633:toxicity
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D003404:Creatinine; C044834:iodixanol