title: Complete resolution of minocycline pigmentation following a single treatment with non-ablative 1550-nm fractional resurfacing in combination with the 755-nm Q-switched alexandrite laser.
abstract: Pigmentation secondary to minocycline ingestion is an uncommon adverse event affecting 3.7-14.8% of treated individuals for which few effective therapies are available. Three patterns of minocycline pigmentation have a characteristic clinical and histological appearance. The pigment composition in each variety is different and occurs at varying skin depths. Accordingly, a tailored approach according to the type of minocycline pigmentation is crucial for treatment success. The purpose of this intervention was to evaluate the efficacy of non-ablative fractional photothermolysis in combination with the Q-switched alexandrite laser for the treatment of type I minocycline pigmentation on the face. A patient with type I minocycline pigmentation was treated with non-ablative 1550-nm fractional photothermolysis followed immediately by 755-nm Q-switched alexandrite laser and then observed clinically to determine the outcome of this modality. The patient was seen in clinic 1 month later following her single treatment session and 100% clearance of all blue facial pigment was observed. Non-ablative fractional photothermolysis in combination with the 755-nm Q-switched alexandrite laser should be considered for treatment of type I minocycline pigmentation.
authors.affiliation: University of Cincinnati Medical Center, Cincinnati, Ohio.
authors.forename: Ramya K
authors.initials: RK
authors.lastname: Vangipuram
authors.affiliation: University of Texas at Houston, Houston, Texas.
authors.forename: Whitney L
authors.initials: WL
authors.lastname: DeLozier
authors.affiliation: Dermatology and Laser Surgery Center, Houston, Texas.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Geddes
authors.affiliation: University of Texas at Houston, Houston, Texas.|Dermatology and Laser Surgery Center, Houston, Texas.|Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Friedman
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced / Q000601:surgery*; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline
keywords: Q-switched alexandrite laser; minocycline pigmentation; non-ablative 1550-nm fractional photothermolysis