title: Effect of survivin on tumor growth of colorectal cancer in vivo.
abstract: Survivin, a member of the inhibitor of apoptosis gene family regulates two critical processes in neoplastic transformation, namely, cell proliferation and apoptosis. This study aimed to detect the effect of survivin on tumor growth of colorectal cancer (CRC) in vivo. We found that inhibition of survivin by interference decreased the sizes and weights of xenografts in nude mice. The number of apoptotic cells of the shRNA survivin group was higher than that of the black group and the shRNA control group. The downregulated expression of survivin decreased the expression levels of bcl2 and ki67. Our results indicated that inhibition of survivin significantly enhanced the inhibition of tumor growth and induced apoptosis. Survivin is an attractive target for CRC treatment.
authors.affiliation: Department of Pathology, Anhui Medical University Hefei 230032, Anhui Province, China.
authors.forename: Yongping
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Department of Pathology, Cancer Hospital and Institute, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ma
authors.affiliation: Department of Pathology, Anhui Medical University Hefei 230032, Anhui Province, China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Pathology, Anhui Medical University Hefei 230032, Anhui Province, China.
authors.forename: Liyu
authors.initials: L
authors.lastname: Cao
authors.affiliation: Department of Pathology, Anhui Medical University Hefei 230032, Anhui Province, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Pathology, Anhui Medical University Hefei 230032, Anhui Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Pathology, The First People's Hospital Hefei 230061, Anhui Province, China.
authors.forename: Nana
authors.initials: N
authors.lastname: Lu
authors.affiliation: Department of Pathology, Anhui Medical University Hefei 230032, Anhui Province, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yin
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics* / Q000378:metabolism; D019394:Ki-67 Antigen / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D000077022:Survivin
chemical_list: C117749:Birc5 protein, mouse; D051034:Inhibitor of Apoptosis Proteins; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D012097:Repressor Proteins; D000077022:Survivin; C052617:Bcl2 protein, mouse
keywords: RNA interference; Survivin; apoptosis; colorectal cancer; proliferation