title: Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model.
abstract: Utilizing small animal magnetocardiograms (MCG), we have developed a diagnostic method to detect the development of pulmonary hypertension (PH) in a rat heart. We obtained multiple MCG of rats with monocrotaline-induced PH and monitored the development of pathophysiological conditions. Current dipole estimation was then applied to determine the association between abnormal propagation of the cardiac excited wavefront and disease states. The progress of right ventricular hypertrophy correlated with a decrease in the angles of the current dipoles during R and S waves. In addition, clear changes in the current dipole angles during S waves were observed 9-19 days before the availability of echocardiographic diagnosis of the PH. Our results showed, using a rat PH model, that continuous monitoring of myocardial conditions allows PH to be detected at an earlier stage than echocardiographic screening.
authors.forename: Shotaro
authors.initials: S
authors.lastname: Yasuda
authors.forename: Sho
authors.initials: S
authors.lastname: Higano
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ishiyama
authors.forename: Yumie
authors.initials: Y
authors.lastname: Ono
authors.forename: Ichige
authors.initials: I
authors.lastname: Kajimura
authors.forename: Susumu
authors.initials: S
authors.lastname: Minamisawa
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006976:Hypertension, Pulmonary; D017380:Hypertrophy, Right Ventricular; D016686:Monocrotaline; D011651:Pulmonary Artery; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016686:Monocrotaline