title: Dimeric acylphloroglucinols from Hypericum austrobrasiliense exhibiting antinociceptive activity in mice.
abstract: Three dimeric acylphloroglucinols, austrobrasilol A, austrobrasilol B and isoaustrobrasilol B were isolated from the flowers of Hypericum austrobrasiliense (Hypericaceae, section Trigynobrathys). Their structures were elucidated using mass spectrometry and NMR experiments (1D and 2D), and by comparison with previously reported data for other dimeric acylphloroglucinols isolated from Hypericum and Elaphoglossum genera. The three compounds were orally administered in mice at equimolar doses to uliginosin B (15mg/kg, p.o.) displaying antinociceptive activity in the hot-plate test. The compounds did not induce motor impairment in the rotarod apparatus.
authors.affiliation: Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga 2752, Porto Alegre/RS 90610-000, Brazil.
authors.forename: Henrique
authors.initials: H
authors.lastname: Bridi
authors.affiliation: Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga 2752, Porto Alegre/RS 90610-000, Brazil.
authors.forename: Gari V
authors.initials: GV
authors.lastname: Ccana-Ccapatinta
authors.affiliation: Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga 2752, Porto Alegre/RS 90610-000, Brazil.
authors.forename: Eveline D
authors.initials: ED
authors.lastname: Stolz
authors.affiliation: Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga 2752, Porto Alegre/RS 90610-000, Brazil.
authors.forename: Gabriela C
authors.initials: GC
authors.lastname: Meirelles
authors.affiliation: Programa de Pós Graduação em Avaliação de Impactos Ambientais, UNILASALLE, Av. Victor Barreto, 2288, Canoas/RS 92010000, Brazil.
authors.forename: Sérgio A L
authors.initials: SAL
authors.lastname: Bordignon
authors.affiliation: Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga 2752, Porto Alegre/RS 90610-000, Brazil.
authors.forename: Stela M K
authors.initials: SMK
authors.lastname: Rates
authors.affiliation: Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga 2752, Porto Alegre/RS 90610-000, Brazil. Electronic address: gilsane@farmacia.ufrgs.br.
authors.forename: Gilsane L
authors.initials: GL
authors.lastname: von Poser
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D001938:Brazil; D020902:Hypericum / Q000737:chemistry*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000700:Analgesics; C000611091:austrobrasilol A; C000611092:austrobrasilol B; C000611093:isoaustrobrasilol B; D010696:Phloroglucinol; C547933:uliginosin B
keywords: Antinociceptive activity; Dimeric acylphloroglucinols; Hypericaceae; Hypericum austrobrasiliense