title: Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease.
abstract: The consequences of using aspirin (ASA) for the pathogenesis of Chagas disease are unclear. This study evaluated the effects of treatment of Chagas disease with ASA on the esophageal nitrergic myenteric neuron population and esophageal wall in mice. We observed that treatment of chagasic infection with ASA protects the esophageal myenteric neurons from the atrophy caused by the Trypanosoma cruzi infection. The mice were infected with 1300 trypomastigotes of Y strain T. cruzi intraperitoneally. Part of infected mice was treated with ASA from fifth to twelfth day after inoculation. Our data support the hypothesis that eicosanoids given during the acute phase of the chagasic infection may act as immunomodulators aiding the transition to and maintenance of the chronic phase of the disease. Besides, ASA treatment did not provoke alterations in the esophageal wall and the myenteric neurons in infected mice.
authors.affiliation: Department of Morphological Sciences, Universidade Estadual de Maringá, Maringá, Brazil.
authors.forename: C L
authors.initials: CL
authors.lastname: Massocatto
authors.affiliation: Department of Morphological Sciences, Universidade Estadual de Maringá, Maringá, Brazil.
authors.forename: N M
authors.initials: NM
authors.lastname: Moreira
authors.affiliation: Department of Morphological Sciences, Universidade Estadual de Maringá, Maringá, Brazil.
authors.forename: E
authors.initials: E
authors.lastname: Muniz
authors.affiliation: Department of Pathological Sciences, Universidade Estadual de Londrina, Londrina, Brazil.
authors.forename: P
authors.initials: P
authors.lastname: Pinge-Filho
authors.affiliation: Department of Statistics, Universidade Estadual de Maringá, Maringá, Brazil.
authors.forename: R M
authors.initials: RM
authors.lastname: Rossi
authors.affiliation: Department of Histology, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.
authors.forename: E J de A
authors.initials: EJ
authors.lastname: Araújo
authors.affiliation: Department of Morphological Sciences, Universidade Estadual de Maringá, Maringá, Brazil.
authors.forename: D de M G
authors.initials: DM
authors.lastname: Sant'Ana
mesh_terms: D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001284:Atrophy / Q000517:prevention & control; D014355:Chagas Disease / Q000188:drug therapy* / Q000469:parasitology; D002908:Chronic Disease; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004195:Disease Models, Animal; D004947:Esophagus / Q000294:innervation*; D008297:Male; D051379:Mice; D009197:Myenteric Plexus / Q000187:drug effects* / Q000473:pathology; D026602:Nitrergic Neurons / Q000187:drug effects* / Q000473:pathology; D016896:Treatment Outcome; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D016861:Cyclooxygenase Inhibitors; D001241:Aspirin
keywords: Chagas disease; acetylsalicylic acid; enteric nervous system; esophagus; myenteric plexus