title: Nrf2 signaling and redox homeostasis in the aging heart: A potential target to prevent cardiovascular diseases?
abstract: Aging process is often accompanied with a high incidence of cardiovascular diseases (CVD) due to the synergistic effects of age-related changes in heart morphology/function and prolonged exposure to injurious effects of CVD risk factors. Oxidative stress, considered a hallmark of aging, is also an important feature in pathologies that predispose to CVD development, like hypertension, diabetes and obesity. Approaches directed to prevent the occurrence of CVD during aging have been explored both in experimental models and in controlled clinical trials, in order to improve health span, reduce hospitalizations and increase life quality during elderly. In this review we discuss oxidative stress role as a main risk factor that relates CVD with aging. As well as interventions that aim to reduce oxidative stress by supplementing with exogenous antioxidants. In particular, strategies of improving the endogenous antioxidant defenses through activating the nuclear factor related-2 factor (Nrf2) pathway; one of the best studied molecules in cellular redox homeostasis and a master regulator of the antioxidant and phase II detoxification response.
authors.affiliation: Department of Cardiovascular Biomedicine, National Institute of Cardiology "Ignacio Chavez", Juan Badiano No. 1, Section XVI, 14080 D.F. Mexico, Mexico; Department of Health Sciences, Autonomous Metropolitan University-Iztapalapa, Mexico City, Mexico.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Silva-Palacios
authors.affiliation: Department of Health Sciences, Autonomous Metropolitan University-Iztapalapa, Mexico City, Mexico.
authors.forename: Mina
authors.initials: M
authors.lastname: Königsberg
authors.affiliation: Department of Cardiovascular Biomedicine, National Institute of Cardiology "Ignacio Chavez", Juan Badiano No. 1, Section XVI, 14080 D.F. Mexico, Mexico. Electronic address: azazuetam@yahoo.com.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Zazueta
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D061745:Antioxidant Response Elements / Q000502:physiology; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D051267:NF-E2-Related Factor 2 / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human
keywords: Aging; Cardiovascular system; Nrf2; Oxidative stress