title: The catalytic enantioselective synthesis of tetrahydroquinolines containing all-carbon quaternary stereocenters via the formation of aza-ortho-xylylene with 1,2-dihydroquinoline as a precursor.
abstract: Tetrahydroquinolines () with an all-carbon quaternary stereocenter were effectively obtained via the in situ formation of aza-ortho-xylylene () with easily accessible 1,2-dihydroquinolines as precursors. The reaction was rationalized with chiral phosporic acid to afford chiral with high yield and excellent enantioselectivity.
authors.affiliation: Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Science, Chengdu, Sichuan 610041, China. ligx@cib.ac.cn tangzhuo@cib.ac.cn.
authors.forename: Guangxun
authors.initials: G
authors.lastname: Li
authors.affiliation: Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Science, Chengdu, Sichuan 610041, China. ligx@cib.ac.cn tangzhuo@cib.ac.cn.
authors.forename: Hongxin
authors.initials: H
authors.lastname: Liu
authors.affiliation: College of Chemical Engineering, Si Chuan University, Chengdu, Sichuan 610041, China.
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Chemical Engineering, Si Chuan University, Chengdu, Sichuan 610041, China.
authors.forename: Shiqi
authors.initials: S
authors.lastname: Zhang
authors.affiliation: College of Art and Sciences, Shanxi Agricultural University Taigu, Shanxi 030800, China.
authors.forename: Shujun
authors.initials: S
authors.lastname: Lai
authors.affiliation: Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Science, Chengdu, Sichuan 610041, China. ligx@cib.ac.cn tangzhuo@cib.ac.cn.
authors.forename: Ling
authors.initials: L
authors.lastname: Tang
authors.affiliation: College of Art and Sciences, Shanxi Agricultural University Taigu, Shanxi 030800, China.
authors.forename: Jinzhong
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Science, Chengdu, Sichuan 610041, China. ligx@cib.ac.cn tangzhuo@cib.ac.cn.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Tang
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D015363:Quinolones; D002244:Carbon