title: Hsa-miR-449a genetic variant is associated with risk of gastric cancer in a Chinese population.
abstract: Gastric cancer (GC) is one of the most common malignancies and one of the major causes of cancer-related deaths worldwide. In the present study, we investigated the association between miR-449a rs112310158 SNP and GC risk. Our findings revealed that a variant GG genotype increased the risk of occurrence of GC compared to a wild type AA genotype (OR = 2.542, 95% CI: 1.304-4.954, P = 0.005). Specifically, the G allele reduced the risk of occurrence of cervical cancer in women compared to the A allele (OR = 1.279, 95% CI: 1.012-1.617, P = 0.043). In conclusion, our findings suggest that miR-449a rs112310158 is a genetic risk factor for GC.
authors.affiliation: Emzymological Institute, The Affiliated Hospital of Nantong University Nantong 226001, Jiangsu, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Shi
authors.affiliation: Department of Radiotherapy, Taixing People's Hospital Taixing 225400, Jiangsu, China.
authors.forename: Yangchen
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Oncology, Taixing People's Hospital Taixing 225400, Jiangsu, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Oncology, Taixing People's Hospital Taixing 225400, Jiangsu, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D060888:Real-Time Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: C544530:MIRN449 microRNA, human; D035683:MicroRNAs
keywords: Gastric cancer; miR-449a; polymorphism