title: Bioactive spirostane glycosides from Tacca plantaginea.
abstract: Eight new spirostane glycosides, taccaosides E-L (2-7, 11, and 14), along with 7 known spirostane glycosides were isolated from the extract of the whole plants of Tacca plantaginea (Hance) Drenth. Their structures were established on the basis of physical data, spectroscopic analysis (MS, 1D and 2D NMR), and chemical methods. The cytotoxicities of the isolates were evaluated in vitro against two human cancer cell lines (HEK293 and HepG2). The results showed that compound 1 had the strongest cytotoxic activity with IC50 values of 1.7 μM and 1.2 μM against the two cancer cell lines, respectively. Furthermore, the spirostane glycosides with 17α-hydroxyl group at their aglycones (10, 12, and 15) were tested for the induced platelet aggregation activity.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Yan
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Yong-Ai
authors.initials: YA
authors.lastname: Si
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ni
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
authors.forename: Li
authors.initials: L
authors.lastname: He
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: haiyangliu@mail.kib.ac.cn.
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Liu
mesh_terms: D027743:Dioscoreaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D057809:HEK293 Cells; D056945:Hep G2 Cells; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D013150:Spirostans / Q000737:chemistry*
chemical_list: D006027:Glycosides; D013150:Spirostans
keywords: Cytotoxicity; Induced platelet aggregation activity; Spirostane glycosides; Tacca plantaginea; Taccaosides E-L