title: The somatotropic axis may not modulate ageing and longevity in humans.
abstract: Studies in nematodes and mice have shown that the somatotropic axis can modulate their longevity and it has been argued that it could also modulate human longevity. Thus, like nematodes and mice, human beings should live longer when facing starvation and genetic variation of the somatotropic axis should be linked to longevity. This article argues that, because the life-history strategies of humans are very different from those of mice, these hypotheses are not warranted.
authors.affiliation: Centre de Recherches sur la Cognition Animale, Centre de Biologie Intégrative, Université de Toulouse, CNRS, UPS, Toulouse, France. eric.le-bourg@univ-tlse3.fr.
authors.forename: Éric
authors.initials: É
authors.lastname: Le Bourg
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D049628:Body Size; D002149:Energy Intake; D013006:Growth Hormone / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D008136:Longevity / Q000502:physiology*; D010902:Pituitary Gland / Q000502:physiology*
chemical_list: D007328:Insulin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone
keywords: Ageing; Growth hormone; IGF-1; Life history strategies; Longevity; Somatotropic axis