title: Variation of resting energy expenditure after the first chemotherapy cycle in acute leukemia patients.
abstract: Changes in resting energy expenditure (REE) of cancer patients vary depending on type of tumor, treatment time point and kind of treatment. Little is known about REE of acute leukemia adult patients after treatment, especially with results related to body weight or fat free mass (FFM). This study aimed to assess changes in REE of acute leukemia adult patients before and after the first remission induction. Evaluation of REE was performed by indirect calorimetry and predicted REE was calculated by Harris-Benedict equation. Weight and height were measured and compared to a control group of healthy individuals. FFM was assessed by bioelectrical impedance for adjusting REE values. We evaluated 18 patients and 26 healthy individuals. At diagnosis, patients presented REE, REE/weight, and REE/FFM higher than the controls. Reductions of REE, REE/weight, and REE/FFM were also observed in patients after the first cycle of chemotherapy. The predicted REE for the patients group showed significant lower value compared with measured REE. Before the first cycle of chemotherapy REE was increased but undergoes a reduction after treatment, reaching values similar to the controls. For predictive Harris-Benedict equation, stress factors should be added to avoid underestimation of REE before and after chemotherapy.
authors.affiliation: a Faculty of Medicine of Ribeirão Preto, University of São Paulo , São Paulo , Brazil.
authors.forename: Paula Cristina
authors.initials: PC
authors.lastname: Galati
authors.affiliation: b Department of Internal Medicine , Faculty of Medicine of Ribeirão Preto, University of São Paulo , Av. Bandeirantes, São Paulo , Brazil.
authors.forename: Paula Garcia
authors.initials: PG
authors.lastname: Chiarello
authors.affiliation: b Department of Internal Medicine , Faculty of Medicine of Ribeirão Preto, University of São Paulo , Av. Bandeirantes, São Paulo , Brazil.
authors.forename: Belinda Pinto
authors.initials: BP
authors.lastname: Simões
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001823:Body Composition; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies