title: Photoacoustic tomography of vascular compliance in humans.
abstract: Characterization of blood vessel elastic properties can help in detecting thrombosis and preventing life-threatening conditions such as acute myocardial infarction or stroke. Vascular elastic photoacoustic tomography (VE-PAT) is proposed to measure blood vessel compliance in humans. Implemented on a linear-array-based photoacoustic computed tomography system, VE-PAT can quantify blood vessel compliance changes due to simulated thrombosis and occlusion. The feasibility of the VE-PAT system was first demonstrated by measuring the strains under uniaxial loading in perfused blood vessel phantoms and quantifying their compliance changes due to the simulated thrombosis. The VE-PAT system detected a decrease in the compliances of blood vessel phantoms with simulated thrombosis, which was validated by a standard compression test. The VE-PAT system was then applied to assess blood vessel compliance in a human subject. Experimental results showed a decrease in compliance when an occlusion occurred downstream from the measurement point in the blood vessels, demonstrating VE-PAT’s potential for clinical thrombosis detection.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Hai
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jinyang
authors.initials: J
authors.lastname: Liang
authors.forename: Chiye
authors.initials: C
authors.lastname: Li
authors.forename: Lihong V
authors.initials: LV
authors.lastname: Wang
mesh_terms: D000328:Adult; D000818:Animals; D001808:Blood Vessels / Q000473:pathology / Q000502:physiology*; D002417:Cattle; D004548:Elasticity; D005385:Fingers / Q000098:blood supply; D005780:Gelatin / Q000737:chemistry; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D010477:Perfusion; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000379:methods*; D013927:Thrombosis / Q000473:pathology; D014054:Tomography / Q000379:methods*; D014655:Vascular Resistance
chemical_list: D005780:Gelatin