title: Jet injection of a monoclonal antibody: A preliminary study.
abstract: Monoclonal antibodies (mAbs) represent a major group of biotherapeutics. The high concentration and volume of drug administered together with a shift to administration via the subcutaneous route have generated interest in alternative delivery technologies. The feasibility of using a novel, highly controllable jet injection technology to deliver a mAb is presented. The effect of delivery parameters on protein structure were evaluated and compared with delivery using a conventional needle and syringe. Injection of mAb into a rat model showed that jet injection using the device resulted in more rapid absorption and longer duration of exposure.
authors.forename: N Catherine
authors.initials: NC
authors.lastname: Hogan
authors.forename: A M
authors.initials: AM
authors.lastname: Cloutier
authors.forename: I W
authors.initials: IW
authors.lastname: Hunter
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000378:metabolism / Q000493:pharmacokinetics; D001682:Biological Availability; D015151:Immunoblotting; D007277:Injections, Jet / Q000295:instrumentation* / Q000379:methods*; D007279:Injections, Subcutaneous / Q000295:instrumentation / Q000379:methods; D008297:Male; D009339:Needles; D017208:Rats, Wistar; D054380:Receptors, CXCR5 / Q000276:immunology; D013594:Syringes
chemical_list: D000911:Antibodies, Monoclonal; D054380:Receptors, CXCR5