title: Commensal bacteria modulate the tumor microenvironment.
abstract: It has been recently shown that gut microbes modulate whole host immune and hormonal factors impacting the fate of distant preneoplastic lesions toward malignancy or regression. This raises the possibility that the tumor microenvironment interacts with broader systemic microbial-immune networks. These accumulated findings suggest novel therapeutic opportunities for holobiont engineering in emerging tumor microenvironments.
authors.affiliation: Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Greece 54124.
authors.forename: Theofilos
authors.initials: T
authors.lastname: Poutahidis
authors.affiliation: Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: serdman@mit.edu.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Erdman
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D002471:Cell Transformation, Neoplastic / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D000069196:Gastrointestinal Microbiome; D054884:Host-Pathogen Interactions; D006801:Humans; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D012307:Risk Factors; D015398:Signal Transduction; D013559:Symbiosis; D059016:Tumor Microenvironment
keywords: Carcinogenesis; Commensal; Microbes; Tumor macroenvironment; Tumor microenvironment