title: Thrombocytopenia-associated multi-organ failure caused by diabetic ketoacidosis.
abstract: Thrombocytopenia-associated multi-organ failure (TAMOF) is an increasingly reported entity in the pediatric intensive care unit. The clinical presentation is similar to thrombotic thrombocytopenic purpura, but with no evidence of hemolysis and no schistocytes on peripheral smear. We report a case of TAMOF induced by diabetic ketoacidosis and treated with therapeutic plasma exchange (TPE). Early diagnosis and initiation of TPE significantly decrease the morbidity associated with TAMOF.
authors.affiliation: Pediatric Residency Training Program, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Tarek
authors.initials: T
authors.lastname: Alsaied
authors.affiliation: Center for Acute Care Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.|Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Goldstein
authors.affiliation: Center for Acute Care Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Kaddourah
authors.affiliation: Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Sue E
authors.initials: SE
authors.lastname: Poynter
mesh_terms: D000293:Adolescent; D016883:Diabetic Ketoacidosis / Q000150:complications*; D005260:Female; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications*
keywords: diabetes mellitus; diabetic ketoacidosis; multiple organ failure; plasma exchange; thrombocytopenia