title: [Application of fibrin sealant in patients operated on for differentiated thyroid cancer. What do we improve?].
abstract: BACKGROUND
  In recent years, several publications have shown that new adhesives and sealants, like Tissucol(®), applied in thyroid space reduce local complications after thyroidectomies.
  
  
  OBJECTIVE
  To demonstrate the effectiveness of fibrin glue Tissucol(®) in reducing the post-operative hospital stay of patients operated on for differentiated thyroid carcinoma in which total thyroidectomy with central and unilateral node neck dissection was performed (due to the debit drains decrease), with consequent cost savings.
  
  
  METHODS
  A prospective randomised study was conducted during the period between May 2009 and October 2013 on patients with differentiated thyroid carcinoma with cervical nodal metastases, and subjected to elective surgery. Two groups were formed: one in which Tissucol(®) was used (case group) and another where it was not used (control group). Patients were operated on by surgeons specifically dedicated to endocrine surgical pathology, using the same surgical technique in all cases.
  
  
  RESULTS
  A total of 60 total thyroidectomies with lymph node dissection were performed, with 30 patients in the case group, and 30 patients in control group. No statistically significant differences were observed in most of the studied variables. However, the case group had a shorter hospital stay than the control group with a statistically significant difference (p<0.05).
  
  
  CONCLUSIONS
  Implementation of Tissucol(®) has statistically and significantly reduced the hospital stay of patients undergoing total thyroidectomy with neck dissection, which represents a significant reduction in hospital costs. This decrease in hospital stay has no influence on the occurrence of major complications related to the intervention.
authors.affiliation: Unidad de Cirugía General y Endocrina, Departamento de Cirugía General y Digestiva, Instituto de Enfermedades Digestivas y Metabólicas, Hospital Clínic y Provincial de Barcelona, Universidad de Barcelona, CIRBERHED, IDIBAPS, Barcelona, España. Electronic address: ovidal@clinic.ub.es.
authors.forename: Óscar
authors.initials: Ó
authors.lastname: Vidal-Pérez
authors.affiliation: Unidad de Cirugía General y Endocrina, Departamento de Cirugía General y Digestiva, Instituto de Enfermedades Digestivas y Metabólicas, Hospital Clínic y Provincial de Barcelona, Universidad de Barcelona, CIRBERHED, IDIBAPS, Barcelona, España.
authors.forename: Luis
authors.initials: L
authors.lastname: Flores-Siguenza
authors.affiliation: Unidad de Cirugía General y Endocrina, Departamento de Cirugía General y Digestiva, Instituto de Enfermedades Digestivas y Metabólicas, Hospital Clínic y Provincial de Barcelona, Universidad de Barcelona, CIRBERHED, IDIBAPS, Barcelona, España.
authors.forename: Mauro
authors.initials: M
authors.lastname: Valentini
authors.affiliation: Unidad de Cirugía General y Endocrina, Departamento de Cirugía General y Digestiva, Instituto de Enfermedades Digestivas y Metabólicas, Hospital Clínic y Provincial de Barcelona, Universidad de Barcelona, CIRBERHED, IDIBAPS, Barcelona, España.
authors.forename: Emiliano
authors.initials: E
authors.lastname: Astudillo-Pombo
authors.affiliation: Unidad de Cirugía General y Endocrina, Departamento de Cirugía General y Digestiva, Instituto de Enfermedades Digestivas y Metabólicas, Hospital Clínic y Provincial de Barcelona, Universidad de Barcelona, CIRBERHED, IDIBAPS, Barcelona, España.
authors.forename: Laureano
authors.initials: L
authors.lastname: Fernández-Cruz
authors.affiliation: Unidad de Cirugía General y Endocrina, Departamento de Cirugía General y Digestiva, Instituto de Enfermedades Digestivas y Metabólicas, Hospital Clínic y Provincial de Barcelona, Universidad de Barcelona, CIRBERHED, IDIBAPS, Barcelona, España.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: García-Valdecasas
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000191:economics / Q000601:surgery*; D002291:Carcinoma, Papillary / Q000191:economics / Q000601:surgery*; D017046:Cost Savings; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000191:economics / Q000627:therapeutic use*; D006488:Hemostasis, Surgical / Q000191:economics / Q000379:methods*; D006801:Humans; D007902:Length of Stay / Q000191:economics; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection / Q000191:economics; D011183:Postoperative Complications / Q000209:etiology; D011446:Prospective Studies; D049291:Seroma / Q000209:etiology; D013964:Thyroid Neoplasms / Q000191:economics / Q000601:surgery*; D013965:Thyroidectomy / Q000191:economics
chemical_list: D015718:Fibrin Tissue Adhesive
keywords: Adhesivo de fibrina; Fibrin tissue adhesive; Lymph node excision; Thyroidectomy; Tiroidectomía; Vaciamiento ganglionar