title: [Old phenotype and new genotypes. Pituitary adenomas].
abstract: Gigantism and acromegaly, usually caused by a pituitary adenoma linked inappropriate secretion of growth hormone (GH), are generally considered as very rare diseases, even if, according to some authors, their cumulative prevalence is about 1/5000. Starting from the historical case of a giant from Liège we shall describe the different types of GH pituitary adenomas and their pathophysiology. We shall particularly discuss rare forms of inherited GH secreting pituitary adenomas like the FIPA (familial inherited isolated pituitary adenomas) and the X-LAG (X linked acrogigantism), both described for the first time in Liège, in 2000 and 2014, respectively.
authors.forename: C
authors.initials: C
authors.lastname: Gérard
authors.forename: H
authors.initials: H
authors.lastname: Jedidi
authors.forename: P
authors.initials: P
authors.lastname: Petrossians
authors.forename: F
authors.initials: F
authors.lastname: Krzesinski
authors.forename: A
authors.initials: A
authors.lastname: Daly
authors.forename: A
authors.initials: A
authors.lastname: Beckers
mesh_terms: D000172:Acromegaly / Q000235:genetics*; D001530:Belgium; D056733:Carney Complex / Q000235:genetics; D041321:Chromosomes, Human, X; D005359:Fibrous Dysplasia, Polyostotic / Q000235:genetics; D005877:Gigantism / Q000235:genetics* / Q000266:history; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000453:epidemiology / Q000235:genetics; D049672:History, 19th Century; D006801:Humans; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics; D009154:Mutation