title: Analysis and classification of oximetry recordings to predict obstructive sleep apnea severity in children.
abstract: Current study is focused around the potential use of oximetry to determine the obstructive sleep apnea-hypopnea syndrome (OSAHS) severity in children. Single-channel SpO2 recordings from 176 children were divided into three severity groups according to the apnea-hypopnea index (AHI): AHI<;1 events per hour (e/h), 1≤AHI<;5 e/h, and AHI ≥5 e/h. Spectral analysis was conducted to define and characterize a frequency band of interest in SpO2. Then we combined the spectral data with the 3% oxygen desaturation index (ODI3) by means of a multi-layer perceptron (MLP) neural network, in order to classify children into one of the three OSAHS severity groups. Following our MLP multiclass approach, a diagnostic protocol with capability to reduce the need of polysomnography tests by 46% could be derived. Moreover, our proposal can be also evaluated, in a binary classification task for two common AHI diagnostic cutoffs (AHI = 1 e/h and AHI= 5 e/h). High diagnostic ability was reached in both cases (84.7% and 85.8% accuracy, respectively) outperforming the clinical variable ODI3 as well as other measures reported in recent studies. These results suggest that the information contained in SpO2 could be helpful in pediatric OSAHS severity detection.
authors.forename: Gonzalo C
authors.initials: GC
authors.lastname: Gutierrez-Tobal
authors.forename: Leila
authors.initials: L
authors.lastname: Kheirandish-Gozal
authors.forename: Daniel
authors.initials: D
authors.lastname: Alvarez
authors.forename: Andrea
authors.initials: A
authors.lastname: Crespo
authors.forename: Mona F
authors.initials: MF
authors.lastname: Philby
authors.forename: Meelad
authors.initials: M
authors.lastname: Mohammadi
authors.forename: Felix
authors.initials: F
authors.lastname: Del Campo
authors.forename: David
authors.initials: D
authors.lastname: Gozal
authors.forename: Roberto
authors.initials: R
authors.lastname: Hornero
mesh_terms: D002648:Child; D006801:Humans; D016571:Neural Networks, Computer; D010092:Oximetry; D010100:Oxygen; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive
chemical_list: D010100:Oxygen