title: Studies of Tumor Suppressor Genes via Chromosome Engineering.
abstract: The development and progression of malignant tumors likely result from consecutive accumulation of genetic alterations, including dysfunctional tumor suppressor genes. However, the signaling mechanisms that underlie the development of tumors have not yet been completely elucidated. Discovery of novel tumor-related genes plays a crucial role in our understanding of the development and progression of malignant tumors. Chromosome engineering technology based on microcell-mediated chromosome transfer (MMCT) is an effective approach for identification of tumor suppressor genes. The studies have revealed at least five tumor suppression effects. The discovery of novel tumor suppressor genes provide greater understanding of the complex signaling pathways that underlie the development and progression of malignant tumors. These advances are being exploited to develop targeted drugs and new biological therapies for cancer.
authors.affiliation: Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Tottori 683-8503, Japan. kugoh@med.tottori-u.ac.jp.|Chromosome Engineering Research Center (CERC), Tottori University, Yonago, Tottori 683-8503, Japan. kugoh@med.tottori-u.ac.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kugoh
authors.affiliation: Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Tottori 683-8503, Japan. ohira@med.tottori-u.ac.jp.
authors.forename: Takahito
authors.initials: T
authors.lastname: Ohira
authors.affiliation: Chromosome Engineering Research Center (CERC), Tottori University, Yonago, Tottori 683-8503, Japan. oshimura@med.tottori-u.ac.jp.
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Oshimura
keywords: PITX1; TERT; chromosome engineering; melanoma; telomerase; tumor suppressor gene