title: [Appropriate prescription, adherence and safety of non-steroidal anti-inflammatory drugs].
abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are the most numerous category of drugs sharing the same mechanism of action and therapeutic activities (anti-inflammatory, analgesic and anti-pyretic). Despite having similar efficacy for pain relieve, the different available NSAIDs show variability in its safety profile. The risk of gastrointestinal and cardiovascular complications varies depending on the dose of NSAID and also the presence of different risk factors. It is necessary, therefore, an individualized case assessment before establishing the indication of the best NSAID for each patient, taking account of the best gastroprotection strategy. Improved prescription and enhanced treatment adherence are central objectives to reduce NSAID-related complications. A recent consensus of the Spanish Association of Gastroenterology and the Spanish societies of Cardiology and Rheumatology intends to promote the rational use of NSAIDs according to new recent studies. This review provides additional aspects to facilitate the optimal decision-making process in the routine use of these drugs in clinical practice.
authors.affiliation: Servicio de Aparato Digestivo, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd); Universidad de Zaragoza, Instituto de Investigación Sanitaria (IIS) Aragón, Zaragoza, España. Electronic address: carlossostres@gmail.com.
authors.forename: Carlos
authors.initials: C
authors.lastname: Sostres
authors.affiliation: Servicio de Aparato Digestivo, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd); Universidad de Zaragoza, Instituto de Investigación Sanitaria (IIS) Aragón, Zaragoza, España.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Lanas
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000517:prevention & control; D000075202:Contraindications; D004347:Drug Interactions; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D057970:Inappropriate Prescribing; D055118:Medication Adherence; D015201:Meta-Analysis as Topic; D059408:Pain Management; D017410:Practice Guidelines as Topic; D012306:Risk
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
keywords: Adherence; Adherencia; Antiinflamatorios no esteroideos; Efectos secundarios; Non-steroidal anti-inflammatory drugs; Safety profile; Seguridad; Side effects