title: Test in canine extraction site preservations by using mineralized collagen plug with or without membrane.
abstract: The aim of this study was to discuss the feasibility of porous mineralized collagen plug and bilayer mineralized collagen-guided bone regeneration membrane in site preservation in extraction sockets. The third mandibular premolars on both sides were extracted from four dogs, thus there were 16 alveolar sockets in all dogs and were randomly assigned into three groups. Group A had six alveolar sockets, and groups B and C had five alveolar sockets, respectively. Each alveolar socket of group A was immediately implanted with a porous mineralized collagen plug and covered with a bilayer mineralized collagen-guided bone regeneration membrane after tooth extraction. Alveolar sockets of group B were implanted with porous mineralized collagen plug only, and group C was set as blank control without any implantation. The healing effects of the extraction sockets were evaluated by gross observation, morphological measurements, and X-ray micro-computed tomography after twelve weeks. Twelve weeks after operation, both groups A and B had more amount of new bone formation compared with group C; in terms of the degree of alveolar bone height, group A was lower than groups B and C with significant differences; the bone mineral density in the region of interest and bone remodeling degree in group A were higher than those of groups B and C. As a result, porous mineralized collagen plug could induce the regeneration of new bone in extraction socket, and combined use of porous mineralized collagen plug and bilayer mineralized collagen guided bone regeneration membrane could further reduce the absorption of alveolar ridge and preserve the socket site.
authors.affiliation: Department of Prosthodontics, Affiliated Stomatological Hospital of Liaoning Medical University, JinZhou, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Prosthodontics, Affiliated Stomatological Hospital of Liaoning Medical University, JinZhou, China wchy1758@sohu.com.
authors.forename: Cheng-Yue
authors.initials: CY
authors.lastname: Wang
authors.affiliation: Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Liaoning Medical University, JinZhou, China.
authors.forename: Zhi-Ying
authors.initials: ZY
authors.lastname: Wang
authors.affiliation: Beijing Allgens Medical Science and Technology Co. Ltd, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Beijing Allgens Medical Science and Technology Co. Ltd, China School of Materials Science and Engineering, Tsinghua University, Beijing, China.
authors.forename: Zhi-Ye
authors.initials: ZY
authors.lastname: Qiu
authors.affiliation: Beijing Allgens Medical Science and Technology Co. Ltd, China.
authors.forename: Tian-Xi
authors.initials: TX
authors.lastname: Song
authors.affiliation: School of Materials Science and Engineering, Tsinghua University, Beijing, China.
authors.forename: Fu-Zhai
authors.initials: FZ
authors.lastname: Cui
mesh_terms: D000539:Alveolar Process / Q000502:physiology / Q000601:surgery / Q000648:ultrastructure; D000818:Animals; D001641:Bicuspid / Q000601:surgery*; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry*; D002113:Calcification, Physiologic; D003094:Collagen / Q000737:chemistry*; D015921:Dental Implants; D004285:Dogs; D008567:Membranes, Artificial; D016062:Porosity; D014081:Tooth Extraction / Q000379:methods*; D020390:Tooth Socket / Q000502:physiology* / Q000601:surgery / Q000648:ultrastructure; D014945:Wound Healing; D055114:X-Ray Microtomography
chemical_list: D018786:Bone Substitutes; D015921:Dental Implants; D008567:Membranes, Artificial; D003094:Collagen
keywords: Mineralized collagen; alveolar ridge; guided bone regeneration membrane; site preservation; tooth-extraction socket