title: Sonochemically synthesized biocompatible zirconium phosphate nanoparticles for pH sensitive drug delivery application.
abstract: The present work reports the synthesis of biocompatible zirconium phosphate (ZP) nanoparticles as nanocarrier for drug delivery application. The ZP nanoparticles were synthesized via a simple sonochemical method in the presence of cetyltrimethylammonium bromide and their efficacy for the delivery of drugs has been tested through various in-vitro experiments. The particle size and BET surface area of the nanoparticles were found to be ~48 nm and 206.51 m(2)/g respectively. The conventional MTT assay and cellular localization studies of the particles, performed on MDA-MB-231 cell lines, demonstrate their excellent biocompatibility and cellular internalization behavior. The loading of curcumin, an antitumor drug, onto the ZP nanoparticles shows the rapid drug uptake ability of the particles, while the drug release study, performed at two different pH values (at 7.4 and 5) depicts pH sensitive release-profile. The MTT assay and cellular localization studies revealed higher cellular inhibition and better bioavailability of the nanoformulated curcumin compared to free curcumin.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur, West Bengal 721302, India. Electronic address: hkalita74@gmail.com.
authors.forename: Himani
authors.initials: H
authors.lastname: Kalita
authors.affiliation: School of Medical Science and Technology, Indian Institute of Technology Kharagpur, West Bengal 721302, India. Electronic address: prasanthkumar999@gmail.com.
authors.forename: B N
authors.initials: BN
authors.lastname: Prashanth Kumar
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur, West Bengal 721302, India. Electronic address: suraj.konar@gmail.com.
authors.forename: Suraj
authors.initials: S
authors.lastname: Konar
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur, West Bengal 721302, India. Electronic address: sang.chem2@gmail.com.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Tantubay
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur, West Bengal 721302, India. Electronic address: mahtomk0@gmail.com.
authors.forename: Madhusudan
authors.initials: M
authors.lastname: Kr Mahto
authors.affiliation: School of Medical Science and Technology, Indian Institute of Technology Kharagpur, West Bengal 721302, India. Electronic address: mahitosh@smst.iitkgp.ernet.in.
authors.forename: Mahitosh
authors.initials: M
authors.lastname: Mandal
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur, West Bengal 721302, India. Electronic address: ami@chem.iitkgp.ernet.in.
authors.forename: Amita
authors.initials: A
authors.lastname: Pathak
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; C027006:zirconium phosphate; D015040:Zirconium
keywords: Biocompatible; MTT assay; Nanocarrier; Nanoformulation; Sonochemical; Zirconium phosphate