title: [Posttranscriptional messenger RNA modifications in eukaryotes].
abstract: Genomewide mapping of posttranscriptional modification in eukaryotic RNA allowed to reveal tens of thousands modification sites. Among modified nucleotides of eukaryotic RNA 6-methyladenosine, 5-methylcytidine, pseudouridine, inosine, and others. Many modification sites are conserved, many are regulated. Function is known for a small subset of modified nucleotides, while the role of majority of them is still obscure. Global character of mRNA modifications allowed scientists to coin a new term, RNA epigenetics. The review is about posttranscriptional messenger RNA modifications in eukaryotes. Main modifications, their role in cell, their mapping techniques and proteins, that are responsible for such RNA modifications are observed.
authors.affiliation: Department of Chemistry, Moscow State University, Moscow, 119991 Russia;|whiteswan92@gmail.com.
authors.forename: I G
authors.initials: IG
authors.lastname: Laptev
authors.affiliation: Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119992 Russia.
authors.forename: A Ya
authors.initials: AY
authors.lastname: Golovina
authors.affiliation: Department of Chemistry, Moscow State University, Moscow, 119991 Russia;|Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119992 Russia.
authors.forename: P V
authors.initials: PV
authors.lastname: Sergiev
authors.affiliation: Department of Chemistry, Moscow State University, Moscow, 119991 Russia;|Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119992 Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Dontsova
mesh_terms: D000818:Animals; D006801:Humans; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D016601:RNA-Binding Proteins
keywords: 5-methylcytidine; 6-methyladenosine; inosine; pseuouridine