title: [Clinical practice guideline for ANCA-associated vasculitis with renal involvement].
abstract: The ANCA-associated vasculitis (AAV) is a group of systemic conditions characterized by inflammation and necrosis in small and medium vessels. AAV with different levels of disease severity could respond to different therapeutics protocols. Early diagnosis and treatment could significantly improve the outcome of the disease. The objective was to investigate the quality evidence in different therapeutical protocols proposed to AAV with renal involvement in pediatrics and adults patients and evaluate the ANCA applicability in AAV diagnosis and outcome. Using methodological search filters, we identified literature in Medline, Embase, Lilacs and Cochrane Trials Register published between 1997 and July 2015. From 4236 articles, 59 were included. The quality of evidence was assessed using the check list designed by the Cochrane Renal Group. The strength of recommendation was determinated by Levels of Evidence (Oxford Centre for Evidence-based Medicine). On the basis of current evidence, 20 recommendations were elaborated for the treatment and monitoring of patients with AAV with renal involvement in several clinical scenarios, in order to provide physicians a rational approach in daily clinical practice.
authors.affiliation: Área Nefrología, Hospital Provincial Simplemente Evita, González Catán, Buenos Aires, Argentina. E-mail: vazquezvanina64@gmail.com.
authors.forename: Vanina
authors.initials: V
authors.lastname: Vazquez
authors.affiliation: Servicio de Nefrología, Hospital de Niños Dr. Ricardo Gutiérrez, Argentina.
authors.forename: Alicia
authors.initials: A
authors.lastname: Fayad
authors.affiliation: División Nefrología, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Argentina.
authors.forename: Gabriela
authors.initials: G
authors.lastname: González
authors.affiliation: Instituto de Nefrología de Buenos Aires (Nephrology), Buenos Aires, Argentina.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Smuclir Quevedo
authors.affiliation: División Nefrología, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Argentina.
authors.forename: Javier
authors.initials: J
authors.lastname: Robaina Sindín
mesh_terms: D000328:Adult; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000150:complications / Q000453:epidemiology / Q000628:therapy*; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001379:Azathioprine / Q000627:therapeutic use; D002648:Child; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000627:therapeutic use; D019317:Evidence-Based Medicine / Q000379:methods*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D060828:Induction Chemotherapy; D007674:Kidney Diseases / Q000150:complications / Q000453:epidemiology / Q000628:therapy*; D060046:Maintenance Chemotherapy; D008727:Methotrexate / Q000627:therapeutic use; D063305:Organ Dysfunction Scores; D010956:Plasmapheresis; D012008:Recurrence; D012720:Severity of Illness Index
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D018501:Antirheumatic Agents; D005938:Glucocorticoids; D003520:Cyclophosphamide; D001379:Azathioprine; D008727:Methotrexate
keywords: ANCA-associated vasculitis; anti-neutrophil cytoplasmic antibodies; eosinophilic granulomatosis with poliangiitis; granulomatosis with polyangiitis; microscopic polyangiitis; treatment