title: Preliminary study of optical coherence tomography imaging to identify microscopic extrathyroidal extension in patients with papillary thyroid carcinoma.
abstract: OBJECTIVE
  We evaluated the feasibility of using optical coherence tomography (OCT), to identify microscopic extrathyroidal extension (mETE) in ex vivo thyroidectomy specimens of patients who underwent thyroidectomy for the treatment of papillary thyroid carcinoma (PTC).
  
  
  METHODS
  A total of 170 ex vivo OCT images of the tumor, were acquired just after completion of thyroidectomy in 17 patients. The OCT images of each patient were separately evaluated by two blinded investigators, and the outcomes were compared with the histopathology reports.
  
  
  RESULTS
  The sensitivity and specificity of mETE identification from the OCT images were 81.4% and 86.0%, respectively, for the first investigator, and 82.9% and 87.0%, respectively, for the second investigator. Substantial agreement between the investigators was verified by Cohen's κ (Cohen's κ = 0.772).
  
  
  CONCLUSIONS
  In this preliminary study of a limited series of ex vivo thyroidectomy specimens, we verified the feasibility of OCT as a method of identifying mETE in patients with PTC.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, South Korea.|Innovative Biomedical Technology Research Center, College of Medicine, Kosin University, Busan, Korea.
authors.forename: Hyoung Shin
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea.
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Shin
authors.affiliation: Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea.
authors.forename: Jung Kweon
authors.initials: JK
authors.lastname: Bae
authors.affiliation: Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea.
authors.forename: Woong Gyu
authors.initials: WG
authors.lastname: Jung
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, South Korea.|Innovative Biomedical Technology Research Center, College of Medicine, Kosin University, Busan, Korea.
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Innovative Biomedical Technology Research Center, College of Medicine, Kosin University, Busan, Korea.|Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea.
authors.forename: Chulho
authors.initials: C
authors.lastname: Oak
authors.affiliation: Department of Pathology, Kosin University College of Medicine, Busan, South Korea.
authors.forename: Bong Kwon
authors.initials: BK
authors.lastname: Chun
authors.affiliation: Innovative Biomedical Technology Research Center, College of Medicine, Kosin University, Busan, Korea.|Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology, Pukyong National University, Busan, South Korea.
authors.forename: Yeh-Chan
authors.initials: YC
authors.lastname: Ahn
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Busan, South Korea.
authors.forename: Byung-Joo
authors.initials: BJ
authors.lastname: Lee
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, South Korea.
authors.forename: Kang Dae
authors.initials: KD
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D002291:Carcinoma, Papillary; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D015588:Observer Variation; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy; D041623:Tomography, Optical Coherence
keywords: extrathyroidal extension; optical coherence tomography; papillary thyroid carcinoma; thyroid