title: Large-scale phenotyping of noise-induced hearing loss in 100 strains of mice.
abstract: A cornerstone technique in the study of hearing is the Auditory Brainstem Response (ABR), an electrophysiologic technique that can be used as a quantitative measure of hearing function. Previous studies have published databases of baseline ABR thresholds for mouse strains, providing a valuable resource for the study of baseline hearing function and genetic mapping of hearing traits in mice. In this study, we further expand upon the existing literature by characterizing the baseline ABR characteristics of 100 inbred mouse strains, 47 of which are newly characterized for hearing function. We identify several distinct patterns of baseline hearing deficits and provide potential avenues for further investigation. Additionally, we characterize the sensitivity of the same 100 strains to noise exposure using permanent thresholds shifts, identifying several distinct patterns of noise-sensitivity. The resulting data provides a new resource for studying hearing loss and noise-sensitivity in mice.
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90089-2821, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Myint
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90089-2821, USA; Bioinformatics and Systems Biology Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0419, USA.
authors.forename: Cory H
authors.initials: CH
authors.lastname: White
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90089-2821, USA; Department of Cell Biology and Genetics, House Research Institute, Los Angeles, CA 90057, USA.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Ohmen
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90089-2821, USA; Department of Cell Biology and Genetics, House Research Institute, Los Angeles, CA 90057, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90089-2821, USA; Department of Cell Biology and Genetics, House Research Institute, Los Angeles, CA 90057, USA.
authors.forename: Juemei
authors.initials: J
authors.lastname: Wang
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90089-2821, USA.
authors.forename: Joel
authors.initials: J
authors.lastname: Lavinsky
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90089-2821, USA.
authors.forename: Pezhman
authors.initials: P
authors.lastname: Salehi
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine of USC, 2250 Alcazar St, Los Angeles, CA 90089-9073, USA.
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Crow
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90089-2821, USA; Department of Cell Biology and Genetics, House Research Institute, Los Angeles, CA 90057, USA.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ohyama
authors.affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90089-2821, USA; Department of Cell Biology and Genetics, House Research Institute, Los Angeles, CA 90057, USA. Electronic address: rick.friedman@med.usc.edu.
authors.forename: Rick A
authors.initials: RA
authors.lastname: Friedman
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001305:Auditory Fatigue; D001933:Brain Stem / Q000503:physiopathology*; D004195:Disease Models, Animal; D016057:Evoked Potentials, Auditory, Brain Stem / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006309:Hearing / Q000235:genetics; D006317:Hearing Loss, Noise-Induced / Q000235:genetics / Q000503:physiopathology*; D006320:Hearing Tests; D009622:Noise / Q000009:adverse effects*; D010641:Phenotype; D013045:Species Specificity
keywords: Hearing loss; Inbred strain; Mouse; Noise