title: Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography.
abstract: A clinical grade prototype of posterior multifunctional Jones matrix optical coherence tomography (JM-OCT) is presented. This JM-OCT visualized depth-localized birefringence in addition to conventional cumulative phase retardation imaging through local Jones matrix analysis. In addition, it simultaneously provides a sensitivity enhanced scattering OCT, a quantitative polarization uniformity contrast, and OCT-based angiography. The probe beam is at 1-μm wavelength band. The measurement speed and the depth-resolution were 100,000 A-lines/s, and 6.6 μm in tissue, respectively. Normal and pathologic eyes are examined and several clinical features are revealed, which includes high birefringence in the choroid and lamina cribrosa, and birefringent layered structure of the sclera. The theoretical details of the depth-localized birefringence imaging and conventional phase retardation imaging are formulated. This formulation indicates that the birefringence imaging correctly measures a depth-localized single-trip phase retardation of a tissue, while the conventional phase retardation can provide correct single-trip phase retardation only for some specific types of samples.
authors.affiliation: Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan ; Tomey Corporation, Nagoya, Aichi, Japan ; Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sugiyama
authors.affiliation: Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan ; Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan.
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Hong
authors.affiliation: Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan ; Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan.
authors.forename: Deepa
authors.initials: D
authors.lastname: Kasaragod
authors.affiliation: Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan ; Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Makita
authors.affiliation: Department of Ophthalmology, Osaka University Hospital, Suita, Osaka, Japan.
authors.forename: Sato
authors.initials: S
authors.lastname: Uematsu
authors.affiliation: Department of Ophthalmology, Osaka University Hospital, Suita, Osaka, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ikuno
authors.affiliation: Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Miura
authors.affiliation: Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan ; Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yasuno
keywords: (110.4500) Optical coherence tomography; (110.5405) Polarimetric imaging; (120.5410) Polarimetry; (170.4460) Ophthalmic optics and devices; (170.4470) Ophthalmology; (170.4500) Optical coherence tomography