title: Copper-Catalyzed Coupling of Oxime Acetates with Isothiocyanates: A Strategy for 2-Aminothiazoles.
abstract: A new strategy for 2-aminothiazoles is developed via the copper-catalyzed coupling of oxime acetates with isothiocyanates. Various 4-substituted and 4,5-disubstituted 2-aminothiazoles were formed smoothly under mild reaction conditions. This process involved copper-catalyzed N-O bond cleavage, activation of vinyl sp(2) C-H bonds, and C-S/C-N bond formations. It is noteworthy that the oxime acetates were used not only as a substrate but also as a single oxidant.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, P. R. China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Tang
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, P. R. China.
authors.forename: Zhongzhi
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, P. R. China.
authors.forename: Chaorong
authors.initials: C
authors.lastname: Qi
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, P. R. China.
authors.forename: Wanqing
authors.initials: W
authors.lastname: Wu
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, P. R. China.
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang