title: Eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammation.
abstract: Eriodictyol, a flavonoid present in citrus fruits, has been reported to have antioxidant and anti-inflammatory effects. In this study, the protective effects of eriodictyol on cisplatin (CP)-induced kidney injury were detected. CP-induced kidney injury model was established by administration of CP (20mg/kg). The results showed that treatment of eriodictyol inhibited the production of blood urea nitrogen (BUN), creatinine, MDA, TBARS, reactive oxygen species (ROS), as well as the production of TNF-α, and IL-1β in kidney tissues induced by CP. Eriodictyol also up-regulated the activities of SOD, CAT, and GSH-PX decreased by CP. Furthermore, eriodictyol was found to up-regulate the expression of Nrf2/HO-1 and inhibited CP-induced NF-κB activation in kidney tissues. In conclusion, eriodictyol protected against CP-induced kidney injury through activating Nrf2 and inhibiting NF-κB activation.
authors.affiliation: Department of Family Medicine, College of Medicine, Dong-A University, Busan 604-714, Republic of Korea; Department of Emergency, Heilongjiang Provincial Hospital, Harbin 150000, China.
authors.forename: Cheng-zhen
authors.initials: CZ
authors.lastname: Li
authors.affiliation: Department of gynaecology and obstetrics, Heilongjiang Provincial Hospital, Harbin 150000, China.
authors.forename: Hai-hong
authors.initials: HH
authors.lastname: Jin
authors.affiliation: Department of Emergency, Heilongjiang Provincial Hospital, Harbin 150000, China.
authors.forename: Hong-xin
authors.initials: HX
authors.lastname: Sun
authors.affiliation: Department of Emergency, Heilongjiang Provincial Hospital, Harbin 150000, China.
authors.forename: Zhong-zhe
authors.initials: ZZ
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin 150000, China.
authors.forename: Jia-xin
authors.initials: JX
authors.lastname: Zheng
authors.affiliation: Department of Nephrology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin 150000, China.
authors.forename: Shu-hua
authors.initials: SH
authors.lastname: Li
authors.affiliation: Department of Family Medicine, College of Medicine, Dong-A University, Busan 604-714, Republic of Korea. Electronic address: lichengzhen12@163.com.
authors.forename: Seong-ho
authors.initials: SH
authors.lastname: Han
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D002945:Cisplatin / Q000009:adverse effects*; D016207:Cytokines / Q000378:metabolism; D019610:Cytoprotection / Q000187:drug effects*; D044950:Flavanones / Q000494:pharmacology* / Q000627:therapeutic use; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D051547:Heme Oxygenase-1 / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy; D007668:Kidney / Q000187:drug effects* / Q000293:injuries* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D016328:NF-kappa B / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016207:Cytokines; D044950:Flavanones; D008565:Membrane Proteins; D016328:NF-kappa B; D017382:Reactive Oxygen Species; D051547:Heme Oxygenase-1; C496542:Hmox1 protein, mouse; D002945:Cisplatin; C007619:eriodictyol
keywords: Cisplatin; Eriodictyol; Kidney injury; NF-κB; Nrf2