title: Pulmonary macrophages activity in CO intoxication.
abstract: The presence of macrophages and their activation on the pulmonary tissues of 21 subjects deceased after CO intoxication has been studied. A notable number of activated macrophages, especially in the interstitial level, have been evidenced, and such phenomenon supports the hypothesis of a possible association between CO intoxication and pulmonary macrophages activity. The highlighted association could be mediated by changes of the surfactant, by impairing of mitochondrial respiration and by release of pro-inflammatory cytokines.
authors.affiliation: Department of Advanced Biomedical Science-Legal Medicine Section, University of Naples "Federico II", Naples, Italy. Electronic address: maria.pieri@unina.it.
authors.forename: Maria
authors.initials: M
authors.lastname: Pieri
authors.affiliation: AORN "Sant'Anna e San Sebastiano" Caserta- Legal Medicine Section, Caserta, Italy. Electronic address: dottgiugliano@tiscali.it.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Giugliano
authors.affiliation: Department of Law, Economics and Mathematical Methods, University of Sannio, Benevento, Italy. Electronic address: givacchi@tin.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Vacchiano
mesh_terms: D000293:Adolescent; D000328:Adult; D002249:Carbon Monoxide Poisoning / Q000473:pathology*; D002452:Cell Count; D005260:Female; D049429:Forensic Pathology; D006801:Humans; D008168:Lung / Q000473:pathology*; D008264:Macrophages / Q000473:pathology*; D008297:Male; D055815:Young Adult
keywords: CO intoxications; Macrophages; Prolonged asphyxia