title: [Merkel cell carcinoma in patient after organ transplantation].
abstract: Merkel cell carcinoma (MCC) is a rare, neuroendocrine tumour of the skin characterized by a very aggressive course. Firm, red-to-purple, typically non tender papules or nodules is a common of it's clinical manifestation. This carcinoma is more common among white Caucasians males in advanced age. The important risk factors for MCC are immunodeficiency or immunosuppression in patients after organ transplantation. MCC observed in organ recipients is associated with especially rapid progression as compared with general population and tendency to metastasis. Surgical excision of primary tumour with adequate margins and sentinel lymph node dissection with adjuvant radiotherapy improves regional control of disease and patients survival. Chemotherapy is usually used as a palliative treatment for advanced forms of the disease.
authors.forename: Joanna
authors.initials: J
authors.lastname: Sułowicz
authors.forename: Anna
authors.initials: A
authors.lastname: Wojas-Pelc
authors.forename: Władysław
authors.initials: W
authors.lastname: Sułowicz
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D015266:Carcinoma, Merkel Cell / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000517:prevention & control; D016377:Organ Transplantation / Q000009:adverse effects*; D010166:Palliative Care; D018714:Radiotherapy, Adjuvant; D012878:Skin Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents