title: Hydroxychloroquine-induced acute generalized exanthematous pustulosis with positive patch-testing.
abstract: Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction, mostly induced by drugs. Hydroxychloroquine have been rarely reported in literature as a causative drug of this reaction. We report a case of AGEP induced by hydroxychloroquine with systemic involvement and confirmed by positive patch testing.
authors.affiliation: Department of Pharmacology, National Center of Pharmacovigilance, 9 Avenue du Dr Zouhaier Essafi 1006, Tunis, Tunisia.
authors.forename: Ons
authors.initials: O
authors.lastname: Charfi
authors.affiliation: Department of Pharmacology, National Center of Pharmacovigilance, 9 Avenue du Dr Zouhaier Essafi 1006, Tunis, Tunisia; Department of Pharmacology, Tunis El Manar University, Faculty of Medicine, 15 Rue Djebel Lakhdhar, La Rabta, 1007, Tunis, Tunisia.
authors.forename: Sarrah
authors.initials: S
authors.lastname: Kastalli
authors.affiliation: Department of Pharmacology, National Center of Pharmacovigilance, 9 Avenue du Dr Zouhaier Essafi 1006, Tunis, Tunisia; Department of Pharmacology, Tunis El Manar University, Faculty of Medicine, 15 Rue Djebel Lakhdhar, La Rabta, 1007, Tunis, Tunisia.
authors.forename: Rym
authors.initials: R
authors.lastname: Sahnoun
authors.affiliation: Department of Pharmacology, National Center of Pharmacovigilance, 9 Avenue du Dr Zouhaier Essafi 1006, Tunis, Tunisia; Department of Pharmacology, Tunis El Manar University, Faculty of Medicine, 15 Rue Djebel Lakhdhar, La Rabta, 1007, Tunis, Tunisia.
authors.forename: Ghozlane
authors.initials: G
authors.lastname: Lakhoua
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000175:diagnosis / Q000209:etiology*; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D018771:Arthralgia / Q000209:etiology / Q000517:prevention & control; D002738:Chloroquine / Q000009:adverse effects / Q000627:therapeutic use; D016903:Drug Monitoring; D004351:Drug Resistance; D004359:Drug Therapy, Combination / Q000009:adverse effects; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000009:adverse effects* / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000503:physiopathology; D010328:Patch Tests; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006886:Hydroxychloroquine; D002738:Chloroquine; D011239:Prednisolone
keywords: Hydroxychloroquine; patch test; pustulosis