title: Maternal obesity and offspring body composition by indirect methods: a systematic review and meta-analysis.
abstract: This study reviewed the evidence that assessed the association between maternal pre-pregnancy body mass index (BMI) and/or gestational weight gain and offspring body composition in childhood. A systematic review was conducted. Cohort studies, case-control studies and randomized controlled trials measuring offspring body composition by indirect methods were included. Meta-analyses of the effect of pre-pregnancy BMI on offspring fat-free mass, body fat percent, and fat mass were conducted through random-effects models. 20 studies were included, most of which reported a positive association of pre-pregnancy BMI with offspring body fat. Standardized mean differences in body fat percent, fat mass and fat-free mass between infants of women with normal pre-pregnancy BMI and those of overweight/obese women were 0.31 percent points (95%CI: 0.19; 0.42), 0.38 kg (95%CI: 0.26; 0.50), and 0.18 kg (95%CI: -0.07; 0.42), respectively. Evidence so far suggests that pre-pregnancy maternal overweight is associated with higher offspring adiposity.
authors.affiliation: Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, Brasil.
authors.forename: Helen
authors.initials: H
authors.lastname: Castillo-Laura
authors.affiliation: Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, Brasil.
authors.forename: Iná S
authors.initials: IS
authors.lastname: Santos
authors.affiliation: Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, Brasil.
authors.forename: Lenice C M
authors.initials: LC
authors.lastname: Quadros
authors.affiliation: Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil.
authors.forename: Alicia
authors.initials: A
authors.lastname: Matijasevich
mesh_terms: D050154:Adiposity; D001724:Birth Weight; D001823:Body Composition / Q000235:genetics*; D015992:Body Mass Index; D001938:Brazil; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology; D050177:Overweight / Q000378:metabolism / Q000503:physiopathology*; D011247:Pregnancy; D015430:Weight Gain / Q000235:genetics*