title: Hybrid Type iterative reconstruction method vs. filter back projection method: Capability for radiation dose reduction and perfusion assessment on dynamic first-pass contrast-enhanced perfusion chest area-detector CT.
abstract: OBJECTIVE
  To directly compare the capability of hybrid-type iterative reconstruction (i.e., adaptive iterative dose reduction using 3D processing: AIDR 3D) and filter back projection (FBP) for radiation dose reduction during dynamic contrast-enhanced (CE-) perfusion area-detector CT (ADCT) for lung and nodule perfusion assessment.
  
  
  METHODS
  Thirty-six patients with lung cancers who underwent perfusion ADCT (SD-ADCT) at 120 mA and were enrolled in this study. ADCT data at 80 mA (reduced-dose ADCT: RD-ADCT), 60 mA (low-dose ADCT: LD-ADCT) and 40 mA (very low-dose ADCT: VLD-ADCT) were computationally simulated using SD-ADCT data, and reconstructed with and without AIDR 3D. Image noise and lung and nodule perfusion parameters were evaluated using ROI measurements. To determine the utility of AIDR 3D for dose reduction, image noise was compared between each protocol with and without AIDR 3D by means of the t-test. Correlations and limits of agreement for parameters obtained with SD-ADCT and other protocols were also evaluated.
  
  
  RESULTS
  Image noise of all protocols with AIDR 3D was significantly lower than that of LD-ADCT and VLD-ADCT without AIDR 3D (p<0.05). Significant correlations for image noise between SD-ADCT and all protocols with AIDR 3D (0.45 ≤ r ≤ 0.99, p<0.0001) were equal to or better than that without AIDR 3D (0.28 ≤ r ≤ 0.99, p<0.0001). The limits of agreement for perfusion parameters with AIDR 3D were smaller than those without AIDR 3D for each tube current.
  
  
  CONCLUSIONS
  AIDR 3D is more effective than FBP for dose reduction of perfusion ADCT while maintaining image quality and reducing measurement errors.
authors.affiliation: Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan; Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. Electronic address: yosirad@med.kobe-u.ac.jp.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Ohno
authors.affiliation: Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Koyama
authors.affiliation: Toshiba Medical Systems Corporation, Otawara, Tochigi, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Fujisawa
authors.affiliation: Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan; Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshikawa
authors.affiliation: Toshiba Medical Systems Corporation, Otawara, Tochigi, Japan.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Inokawa
authors.affiliation: Toshiba Medical Systems Corporation, Otawara, Tochigi, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Sugihara
authors.affiliation: Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Seki
authors.affiliation: Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
authors.forename: Kazuro
authors.initials: K
authors.lastname: Sugimura
mesh_terms: D000368:Aged; D000465:Algorithms; D003287:Contrast Media; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D011446:Prospective Studies; D011829:Radiation Dosage; D011856:Radiographic Image Enhancement; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media
keywords: CT; lung; nodule; perfusion; radiation dose; reconstruction algorithm