title: Reversible cerebral and brain stem dysfunction in n: Hexane neuropathy.
abstract: A 18-year-old male, screen printer by profession developed sensory motor polyneuropathy, change in his behavior, bilateral 6(th) and 7(th) cranial nerve palsies, down beat nystagmus and cerebellar dysarthria. He had bilaterally prolonged P100 latency; left: 137 ms; right: 144 ms. P 37 was not recordable on either side while N 20 was normal. The inter latency difference between Ipsilateral R2 and Contralateral R2 was 6.15 ms, on the left side and normal on the right side. In the follow-up, there was normalization of the blink reflex study, improvement in P100 latency [left: 114 ms; right: 120 ms.] but worsening of peripheral nerve conductions. The sequential clinical recovery was of the behavioral dysfunction, down beat nystagmus, 6(th) nerve, 7(th) nerve involvement and ataxia, in that order. Sural nerve biopsy showed loss of large diameter myelinated fibers.
authors.affiliation: Department of Neurology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.
authors.forename: Vinod
authors.initials: V
authors.lastname: Puri
authors.affiliation: Department of Neurology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.
authors.forename: Abhijit Das
authors.initials: AD
authors.lastname: Gupta
authors.affiliation: Department of Neurology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.
authors.forename: Neera
authors.initials: N
authors.lastname: Chaudhry
authors.affiliation: Department of Pathology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.
authors.forename: Ravindra Kumar
authors.initials: RK
authors.lastname: Saran
keywords: 6th and 7th nerve palsy; blink reflex; central nervous system involvement; down beat nystagmus; n- Hexane neuropathy