title: Music supported therapy promotes motor plasticity in individuals with chronic stroke.
abstract: Novel rehabilitation interventions have improved motor recovery by induction of neural plasticity in individuals with stroke. Of these, Music-supported therapy (MST) is based on music training designed to restore motor deficits. Music training requires multimodal processing, involving the integration and co-operation of visual, motor, auditory, affective and cognitive systems. The main objective of this study was to assess, in a group of 20 individuals suffering from chronic stroke, the motor, cognitive, emotional and neuroplastic effects of MST. Using functional magnetic resonance imaging (fMRI) we observed a clear restitution of both activity and connectivity among auditory-motor regions of the affected hemisphere. Importantly, no differences were observed in this functional network in a healthy control group, ruling out possible confounds such as repeated imaging testing. Moreover, this increase in activity and connectivity between auditory and motor regions was accompanied by a functional improvement of the paretic hand. The present results confirm MST as a viable intervention to improve motor function in chronic stroke individuals.
authors.affiliation: Cognition and Brain Plasticity Group [Bellvitge Biomedical Research Institute] IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08097, Spain.|Department of Basic Psychology, Campus Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, 08097, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Ripollés
authors.affiliation: Cognition and Brain Plasticity Group [Bellvitge Biomedical Research Institute] IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08097, Spain.|Department of Basic Psychology, Campus Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, 08097, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Rojo
authors.affiliation: Cognition and Brain Plasticity Group [Bellvitge Biomedical Research Institute] IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08097, Spain.|Department of Basic Psychology, Campus Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, 08097, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Grau-Sánchez
authors.affiliation: Cognition and Brain Plasticity Group [Bellvitge Biomedical Research Institute] IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08097, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Amengual
authors.affiliation: Cognition and Brain Plasticity Group [Bellvitge Biomedical Research Institute] IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08097, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Càmara
authors.affiliation: Cognition and Brain Plasticity Group [Bellvitge Biomedical Research Institute] IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08097, Spain.|Department of Basic Psychology, Campus Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, 08097, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Marco-Pallarés
authors.affiliation: Hospital Universitari de Bellvitge (HUB), Neurology Section, Campus Bellvitge, University of Barcelona - IDIBELL, L'Hospitalet, 08097, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Juncadella
authors.affiliation: Cognition and Brain Plasticity Group [Bellvitge Biomedical Research Institute] IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08097, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Vaquero
authors.affiliation: Hospital Universitari de Bellvitge (HUB), Neurology Section, Campus Bellvitge, University of Barcelona - IDIBELL, L'Hospitalet, 08097, Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Rubio
authors.affiliation: Department of Physical Medicine and Rehabilitation, Parc de Salut Mar, Hospitals del Mar i de l'Esperança, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Duarte
authors.affiliation: Radiology Unit., Hospital Clinic de Barcelona - IDIBAPS, Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Garrido
authors.affiliation: Institute of Music Physiology and Musicians' Medicine, University of Music, Drama and Media Hannover, Hannover, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Altenmüller
authors.affiliation: Department of Neurology, University of Lübeck, Lübeck, Germany.
authors.forename: T F
authors.initials: TF
authors.lastname: Münte
authors.affiliation: Cognition and Brain Plasticity Group [Bellvitge Biomedical Research Institute] IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08097, Spain. arfornells@gmail.com.|Department of Basic Psychology, Campus Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, 08097, Spain. arfornells@gmail.com.|Catalan Institution for Research and Advanced Studies, ICREA, Barcelona, Spain. arfornells@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez-Fornells
mesh_terms: D000328:Adult; D000368:Aged; D001307:Auditory Perception / Q000502:physiology; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D002908:Chronic Disease; D005260:Female; D006225:Hand / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D009147:Music Therapy; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology; D009483:Neuropsychological Tests; D010291:Paresis / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000534:rehabilitation; D020127:Recovery of Function; D020521:Stroke / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology; D000071939:Stroke Rehabilitation; D016896:Treatment Outcome
keywords: Chronic stroke; Functional connectivity; Music-supported therapy; Plasticity; fMRI