title: Dynamic thalamus parcellation from resting-state fMRI data.
abstract: The thalamus is a relay center between various subcortical brain areas and the cerebral cortex with delineation of its constituent nuclei being of particular interest in many applications. While previous studies have demonstrated efficacy of connectivity-based thalamus segmentation, they used approaches that do not consider the dynamic nature of thalamo-cortical interactions. In this study, we explicitly exploited the dynamic variation of thalamo-cortical connections to identify different states of functional connectivity and performed state-specific thalamus parcellation. With normalized spectral clustering successively applied in temporal and spatial domains, nine thalamo-cortical connectivity states were identified and the dynamic thalamus parcellation revealed finer thalamic structures with improved atlas correspondence. The present results extend our understanding of thalamo-cortical connectivity and provide a more comprehensive view of the thalamo-cortical interaction.
authors.affiliation: University of Shanghai for Science & Technology, Shanghai, 200093, China.|Biomedical Engineering, Emory University & Georgia Institute of Technology, Atlanta, Georgia.
authors.forename: Bing
authors.initials: B
authors.lastname: Ji
authors.affiliation: Biomedical Engineering, Emory University & Georgia Institute of Technology, Atlanta, Georgia.|Institute of Affective and Social Neuroscience, Shenzhen University, Shenzhen, Guangdong, 518060, China.
authors.forename: Zhihao
authors.initials: Z
authors.lastname: Li
authors.affiliation: Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, 610041, China.
authors.forename: Kaiming
authors.initials: K
authors.lastname: Li
authors.affiliation: Biomedical Engineering, Emory University & Georgia Institute of Technology, Atlanta, Georgia.|Marcus Autism Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Georgia.
authors.forename: Longchuan
authors.initials: L
authors.lastname: Li
authors.affiliation: Biomedical Engineering, Emory University & Georgia Institute of Technology, Atlanta, Georgia.
authors.forename: Jason
authors.initials: J
authors.lastname: Langley
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, 410073, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.affiliation: University of Shanghai for Science & Technology, Shanghai, 200093, China.
authors.forename: Shengdong
authors.initials: S
authors.lastname: Nie
authors.affiliation: University of Shanghai for Science & Technology, Shanghai, 200093, China.
authors.forename: Renjie
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Biomedical Engineering, Emory University & Georgia Institute of Technology, Atlanta, Georgia.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Hu
mesh_terms: D002540:Cerebral Cortex / Q000502:physiology; D063132:Connectome; D066264:Datasets as Topic; D006801:Humans; D020407:Internet; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009434:Neural Pathways / Q000502:physiology; D012146:Rest; D013788:Thalamus / Q000502:physiology*
keywords: dynamic parcellation; functional connectivity; normalized spectral clustering; resting state; thalamus