title: Effect of PMX-DHP for sepsis due to ESBL-producing E. coli in an extremely low-birthweight infant.
abstract: We report a case of early onset sepsis caused by (CTX for cefotaximase and M for Munich)-type extended-spectrum β-lactamase-producing Escherichia coli (ESBL E. coli) in a preterm infant weighing 601 g. He was given meropenem and treated for endotoxin absorption with polymyxin B-immobilized fibers with only 8 mL of priming volume. The patient survived without any short-term neurological or respiratory sequelae. The choice of antibiotics is particularly important in seriously ill neonates with sepsis due to ESBL-producing organisms. Polymyxin B hemoperfusion might be an innovative therapy for severe neonatal sepsis and could improve outcome even in an extremely low-birthweight infant.
authors.affiliation: Department of Pediatrics, Juntendo University Urayasu Hospital, Chiba, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Nishizaki
authors.affiliation: Department of Pediatrics, Juntendo University Urayasu Hospital, Chiba, Japan.
authors.forename: Mayu
authors.initials: M
authors.lastname: Nakagawa
authors.affiliation: Department of Pediatrics, Juntendo University Urayasu Hospital, Chiba, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hara
authors.affiliation: Department of Pediatrics, Juntendo University Urayasu Hospital, Chiba, Japan.
authors.forename: Hisayuki
authors.initials: H
authors.lastname: Oda
authors.affiliation: Department of Pediatrics, Juntendo University Urayasu Hospital, Chiba, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Kantake
authors.affiliation: Department of Pediatrics, Juntendo University Urayasu Hospital, Chiba, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Obinata
authors.affiliation: Department of Bacteriology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Uehara
authors.affiliation: Department of Bacteriology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hiramatsu
authors.affiliation: Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shimizu
keywords: direct hemoperfusion; early onset sepsis; extended-spectrum β-lactamase-producing Escherichia coli; extremely low-birthweight infant; polymyxin B-immobilized fiber