title: Polycyclic Aromatic Hydrocarbons-Associated MicroRNAs and Heart Rate Variability in Coke Oven Workers.
abstract: OBJECTIVE
  We aimed to evaluate the association between polycyclic aromatic hydrocarbons (PAHs)-related microRNAs (miRNAs) and heart rate variability indices in coke oven workers.
  
  
  METHODS
  We recruited 365 male coke oven workers and measured urinary PAH metabolites by gas chromatography-mass spectrometry. Five heart rate variability indices were measured using three-channel Holter monitor. Six miRNAs were detected by TaqMan miRNA assays (Life Technologies, Foster City, CA).
  
  
  RESULTS
  miR-24-3p, miR-27a-3p, miR-142-5p, and miR-320b were negatively associated with the root mean of square of successive differences between adjacent normal NN intervals (RMSSD) (P(trend) = 0.006, 0.047, 0.019, 0.011, respectively). miR-142-5p and miR-320b were also negatively associated with standard deviation of all normal to normal NN intervals (SDNN) (P(trend) = 0.01 and 0.035). miR-24-3p, miR-27a-3p, and miR-320b were significantly interacted with multiple PAH metabolites and influenced heart rate variability indices, whereas miR-24-3p also significantly interacted with smoking to influence low frequency (P(interaction) < 0.05 for all).
  
  
  CONCLUSIONS
  Plasma miRNAs might act as potential biomarkers for the adverse effect of PAH exposure on the cardiovascular system.
authors.affiliation: Shenzhen Center for Disease Control and Prevention (Drs Huang, Cheng); Key Laboratory of Environment and Health (Drs Deng, Feng, Zhang, Dai, Li, Wu), Ministry of Education and Ministry of Environmental Protection; State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei (Drs Deng, Feng, Zhang, Dai, Li, Wu); and State Key Lab of Respiratory Disease (Dr Yang), Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical University, Guangdong, China.
authors.forename: Suli
authors.initials: S
authors.lastname: Huang
authors.forename: Qifei
authors.initials: Q
authors.lastname: Deng
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiayun
authors.initials: X
authors.lastname: Dai
authors.forename: Lu
authors.initials: L
authors.lastname: Li
authors.forename: Binyao
authors.initials: B
authors.lastname: Yang
authors.forename: Tangchun
authors.initials: T
authors.lastname: Wu
authors.forename: Jinquan
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis / Q000633:toxicity; D003077:Coke; D006339:Heart Rate; D006801:Humans; D008297:Male; D008669:Metallurgy; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D011084:Polycyclic Aromatic Hydrocarbons / Q000009:adverse effects* / Q000032:analysis / Q000652:urine*
chemical_list: D000395:Air Pollutants, Occupational; D003077:Coke; D035683:MicroRNAs; D011084:Polycyclic Aromatic Hydrocarbons; C527111:MIRN126 microRNA, human; C555159:MIRN142 microRNA, human; C533097:MIR150, human; C543845:MIRN24 microRNA, human; C531388:MIRN27 microRNA, human; C572916:MIRN320 microRNA, human