title: Prognostic Significance of Serum and Urinary Neopterin Concentrations in Patients with Rectal Carcinoma Treated with Chemoradiation.
abstract: OBJECTIVE
  To analyze the prognostic significance of serum and urinary neopterin concentrations in patients with rectal adenocarcinoma treated with (chemo)radiation.
  
  
  METHODS
  Urinary and serum neopterin and peripheral blood cell count were determined in 49 patients with rectal carcinoma before the start of (chemo)radiation.
  
  
  RESULTS
  Neopterin concentrations exhibited a significant inverse correlation with hemoglobin and positive correlation with leukocyte count, platelet count and platelet-to-lymphocyte ratio. Increased serum neopterin concentration was associated with significantly inferior relapse-free survival (RFS) and overall survival. However, a significant association was observed only in 28 patients treated in the neoadjuvant setting. Although increased urinary neopterin was also associated with inferior RFS and overall survival, this was not statistically significant. The neutrophil-to-lymphocyte ratio was also associated with poor prognosis.
  
  
  CONCLUSIONS
  The data presented herein indicate a prognostic significance of serum neopterin concentrations in patients with rectal cancer treated with neoadjuvant chemoradiation.
authors.affiliation: Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.
authors.forename: Michaela
authors.initials: M
authors.lastname: Zezulová
authors.affiliation: Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.
authors.forename: Marie
authors.initials: M
authors.lastname: Bartoušková
authors.affiliation: Department of Clinical Biochemistry, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic Institute of Molecular and Translational Medicine, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Hlídková
authors.affiliation: Department of Hemato-Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.
authors.forename: Jarmila
authors.initials: J
authors.lastname: Juráňová
authors.affiliation: Third Department of Medicine, Charles University Teaching Hospital, Hradec Králové, Czech Republic.
authors.forename: Barbora
authors.initials: B
authors.lastname: Červinková
authors.affiliation: Third Department of Medicine, Charles University Teaching Hospital, Hradec Králové, Czech Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Kasalová
authors.affiliation: Department of Clinical Biochemistry, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic Institute of Molecular and Translational Medicine, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Adam
authors.affiliation: Third Department of Medicine, Charles University Teaching Hospital, Hradec Králové, Czech Republic Department of Analytical Chemistry, Charles University School of Pharmacy, Hradec Králové, Czech Republic.
authors.forename: Lenka Kujovská
authors.initials: LK
authors.lastname: Krčmová
authors.affiliation: Third Department of Medicine, Charles University Teaching Hospital, Hradec Králové, Czech Republic.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Solichová
authors.affiliation: Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.
authors.forename: Karel
authors.initials: K
authors.lastname: Cwiertka
authors.affiliation: Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic Institute of Molecular and Translational Medicine, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic davvrana@gmail.com.
authors.forename: David
authors.initials: D
authors.lastname: Vrána
authors.affiliation: Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic Institute of Molecular and Translational Medicine, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.
authors.forename: Bohuslav
authors.initials: B
authors.lastname: Melichar
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D059248:Chemoradiotherapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000097:blood* / Q000652:urine*; D011379:Prognosis; D012004:Rectal Neoplasms / Q000532:radiotherapy* / Q000628:therapy
chemical_list: D019798:Neopterin
keywords: Chemoradiation; neopterin; prognosis; rectal carcinoma