title: [Influence of As2O3-lipiodol emulsion via transarterial embolization on a VX2 liver tumor model in rabbits].
abstract: To investigate the anticancer efficacy and the hepatic and renal toxicity of As2O3-lipiodol emulsion via transarterial embolization in a rabbit VX2 liver tumor model.
  
  
  
  VX2 tumors were implanted in rabbit livers successfully, followed by transarterial embolization with high-dose As2O3(5 mg/kg with 0.2 mL lipiodol, n=10), low-dose As2O3(1 mg/kg with 0.2 mL lipiodol, n=10), and control(0.2 mL lipiodol, n=10). The growth ratios and microvessel densities(MVDs) of the tumors were estimated by multi-row spiral CT and CD34 immunohistochemical staining, respectively. Hepatic and renal function was also evaluated by means of blood biochemical analysis.
  
  
  
  The growth ratios of the tumors differed significantly among three groups(P<0.01). The high-dose and low dose group showed significantly lower tumor growth ratios[44.05%(-36.40%~64.60%), 95.20%(-11.60%~159.40%)] than control group[145.55%(98.90%~250.30%), all P<0.05]. The MVDs of the tumors were significantly lower in the high-dose(21.4±10.6) and low-dose group(34.1±12.0) than those in control group(57.9±16.1,all P<0.05). The levels of blood ALT and AST obtained 28 days after transarterial embolization were significantly lower in the high-dose[(25.50±12.37)U/L,(24.25±10.89)U/L] and low-dose group[(45.00±14.04)U/L,(35.22±11.86)U/L] than in control group[(79.12±30.52)U/L,(75.25±25.89)U/L, all P<0.05].
  
  
  
  As2O3-lipiodol emulsion via transarterial embolization has anticancer effect without significant hepatic and renal functional damage in rabbit VX2 liver tumors.
authors.affiliation: Department of Radiology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China;Department of Radiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Department of Radiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Chuan-gen
authors.initials: CG
authors.lastname: Guo
authors.affiliation: Department of Radiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Shun-liang
authors.initials: SL
authors.lastname: Xu
authors.affiliation: Department of Radiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Zhi-yi
authors.initials: ZY
authors.lastname: Peng
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Jun-hui
authors.initials: JH
authors.lastname: Sun
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000494:pharmacology*; D004621:Embolization, Therapeutic; D004655:Emulsions / Q000494:pharmacology; D004998:Ethiodized Oil / Q000494:pharmacology*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy*; D010087:Oxides / Q000494:pharmacology*; D011817:Rabbits; D036542:Tomography, Spiral Computed
chemical_list: D000970:Antineoplastic Agents; D001152:Arsenicals; D004655:Emulsions; D010087:Oxides; D004998:Ethiodized Oil; D000077237:Arsenic Trioxide