title: Evaluation of adverse events in atomic bomb survivors receiving curative-intent radiation therapy from 2005 to 2010.
abstract: OBJECTIVE
  To evaluate the safety of radiation therapy (RT) in atomic bomb (A-bomb) survivors (ABS), we evaluated the frequency of RT-associated adverse events (AEs) in ABS.
  
  
  METHODS
  We selected patients who underwent curative external-beam RT (EBRT) at Hiroshima University Hospital between January 2005 and December 2010 and were born before August 1946; the patients were divided into ABS and non-ABS groups, which groups received identical treatments without stratification.
  
  
  RESULTS
  We retrospectively reviewed the medical records of 220 ABS and 753 non-ABS patients. The median age was 72 years. The median observation durations were 41 and 37 months for the ABS and non-ABS groups, respectively. The ABS group had higher frequencies of women, breast cancer patients, and concurrent chemotherapy and had a lower incidence of only acute hematological AEs. However this tendency disappeared when breast cancer patients were excluded, and no significant differences were observed between the ABS and non-ABS groups regarding Grade ⩾ 3 other acute and late AEs. The overall cumulative incidence of Grade ⩾ 3 late AEs did not significantly differ between the ABS and non-ABS groups.
  
  
  CONCLUSIONS
  Notable increases in AEs were not observed during or after RT among ABS. This study clarified that stratification is not required when treating ABS with RT.
authors.affiliation: Department of Radiation Oncology, Graduate School of Biomedical Sciences, Hiroshima University, Japan. Electronic address: yoshikod@hiroshima-u.ac.jp.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Doi
authors.affiliation: Department of Radiation Oncology, Graduate School of Biomedical Sciences, Hiroshima University, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Murakami
authors.affiliation: Department of Radiation Oncology, Graduate School of Biomedical Sciences, Hiroshima University, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kenjo
authors.affiliation: Department of Radiation Oncology, Graduate School of Biomedical Sciences, Hiroshima University, Japan.
authors.forename: Nobuki
authors.initials: N
authors.lastname: Imano
authors.affiliation: Department of Radiation Oncology, Graduate School of Biomedical Sciences, Hiroshima University, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Kimura
authors.affiliation: Department of Radiation Oncology, Graduate School of Biomedical Sciences, Hiroshima University, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nagata
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality* / Q000532:radiotherapy*; D054043:Nuclear Weapons; D012189:Retrospective Studies; D017741:Survivors / Q000706:statistics & numerical data*
keywords: Adverse events; Atomic bomb survivors; Radiation therapy