title: KPC-Like Carbapenemase-Producing Enterobacteriaceae Colonizing Patients in Europe and Israel.
abstract: In a 2008-2011 survey, 17,945 patients in 18 hospital units in Europe and Israel were screened for carriage of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae, resulting in identification of 124 positive patients. The isolates were dominated by Klebsiella pneumoniae sequence type 258 (ST258) KPC-2 and ST512 KPC-3, mainly from Greece and Italy, respectively, whereas Israeli isolates were of diverse species, clones, and KPC variants. Various blaKPC platforms were observed, among which IncFIIK-FIBK plasmids with blaKPC-2/-3 genes in the Tn4401a transposon prevailed.
authors.affiliation: National Medicines Institute, Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Baraniak
authors.affiliation: National Medicines Institute, Warsaw, Poland.
authors.forename: R
authors.initials: R
authors.lastname: Izdebski
authors.affiliation: National Medicines Institute, Warsaw, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Fiett
authors.affiliation: National Medicines Institute, Warsaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Herda
authors.affiliation: University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: L P G
authors.initials: LP
authors.lastname: Derde
authors.affiliation: University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: M J M
authors.initials: MJ
authors.lastname: Bonten
authors.affiliation: Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Adler
authors.affiliation: Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Carmeli
authors.affiliation: University of Antwerp, Antwerp, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Goossens
authors.affiliation: National Medicines Institute, Warsaw, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Hryniewicz
authors.affiliation: INSERM U957 and Université Paris-Est, Créteil, France.
authors.forename: C
authors.initials: C
authors.lastname: Brun-Buisson
authors.affiliation: National Medicines Institute, Warsaw, Poland gniadkow@cls.edu.pl.
authors.forename: M
authors.initials: M
authors.lastname: Gniadkowski
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics*; D015780:Carbapenems / Q000627:therapeutic use*; D016971:Citrobacter freundii / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D004251:DNA Transposable Elements / Q000235:genetics; D004756:Enterobacteriaceae Infections / Q000188:drug therapy* / Q000382:microbiology; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D005060:Europe; D006801:Humans; D007557:Israel; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D010957:Plasmids / Q000235:genetics; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D004251:DNA Transposable Elements; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases; C495220:beta-lactamase KPC-3, Klebsiella pneumoniae; C063912:carbapenemase