title: MRI Measurements of Iron Load in Transfusion-Dependent Patients: Implementation, Challenges, and Pitfalls.
abstract: Magnetic resonance imaging (MRI) has played a key role in studies of iron overload in transfusion-dependent patients, providing insights into the relations among liver and cardiac iron loading, iron chelator dose, and morbidity. Currently, there is rapid uptake of these methods into routine clinical practice as part of the management strategy for iron overload in regularly transfused patients. Given the manifold methods of data acquisition and analysis, there are several potential pitfalls that may result in inappropriate decision making. Herein, we review the challenges of establishing suitable MRI techniques for tissue iron measurement in regularly transfused patients.
authors.affiliation: Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Charles T
authors.initials: CT
authors.lastname: Quinn
authors.affiliation: School of Physics, The University of Western Australia, Crawley, Australia.
authors.forename: Tim G
authors.initials: TG
authors.lastname: St Pierre
mesh_terms: D006801:Humans; D007501:Iron / Q000097:blood; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D019190:Iron Overload / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology; D008279:Magnetic Resonance Imaging; D011859:Radiography; D065227:Transfusion Reaction
chemical_list: D007502:Iron Chelating Agents; D007501:Iron
keywords: anemia; iron overload; magnetic resonance imaging; sickle cell disease; thalassemia; transfusion