title: Emergence of the default-mode network from resting-state to activation-state in reciprocal social interaction via eye contact.
abstract: The default-mode network has been identified as a resting state BOLD response that is often associated with self-referential or sensory task-passive processes. Many recent studies reveal that this vaguely defined network often plays an essential role in many pervasive mental diseases. By taking advantage of the recent development of dyadic fMRI, this study presents the initial experimental evidence that the default-mode network emerges from resting-state to activation-state in social interaction during live eye contact. Moreover, by comparing the BOLD responses between dyadic fMRI and monadic fMRI, it suggests that live eye contact excites empathy networks in the exogenous system which further activates the default mode network in endogenous system; whereas seeing eyes in face pictures activates completely different brain responses in which the default-mode network remains in resting-state.
authors.forename: Ray F
authors.initials: RF
authors.lastname: Lee
mesh_terms: D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D003071:Cognition; D004645:Empathy / Q000502:physiology*; D005123:Eye; D005149:Facial Expression; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008279:Magnetic Resonance Imaging; D008297:Male; D010775:Photic Stimulation; D012677:Sensation