title: Expression of somatostatin receptors (SSTR1-SSTR5) in meningiomas and its clinicopathological significance.
abstract: Meningiomas are benign brain tumors that are usually to recur. Studies have shown in vitro and in vivo that meningiomas, regardless of histology and classification, express somatostatin receptors (SSTRs). We investigated the immunohistochemical expression of five SSTR subtypes (SSTR1-SSTR5) in tumor tissue sections from 60 patients with diagnosis of meningioma who underwent surgical resection and relating it to patient age and sex, tumor histology, location, regrowth/recurrence and follow-up. Mean (SD) patients age was 53.18 (12.6) years and 44 were women (73.3%). According to the WHO histological grading criteria, 47 (78.3%) meningiomas were grade I, 11 (18.3%) were grade II, and 2 (3.3%) were grade III. All five SSTRs were expressed in our sample, at frequencies ranging from 61.6 to 100%, with a predominance of SSTR2. SSTR5 was more frequently expressed in tumors benign than in tumors malignant (P<0.013). Recurrence-free survival rate at 2 years was 75.2%. There were no significant differences in SSTR expression regarding age, sex, tumor location and regrowth/recurrence. SSTR expression was detected at a significant frequency in this series. SSTR5 showed higher expression in tumors benign supporting the use of these SSTRs in diagnostic of meningiomas and their influence in process of tumorigenesis in meningiomas recurrence.
authors.affiliation: Department of Laboratory of Pathology, Hospital Complex Santa Casa de Porto Alegre, University of Health Sciences of Porto Alegre Rio Grande do Sul, Brazil ; Neuroendocrinology Center, Hospital Complex Santa Casa de Porto Alegre, University of Health Sciences of Porto Alegre Rio Grande do Sul, Brazil.
authors.forename: Camila Batista de Oliveira
authors.initials: CB
authors.lastname: Silva
authors.affiliation: Department of Laboratory of Pathology, Hospital Complex Santa Casa de Porto Alegre, University of Health Sciences of Porto Alegre Rio Grande do Sul, Brazil ; Neuroendocrinology Center, Hospital Complex Santa Casa de Porto Alegre, University of Health Sciences of Porto Alegre Rio Grande do Sul, Brazil.
authors.forename: Bárbara Roberta
authors.initials: BR
authors.lastname: Ongaratti
authors.affiliation: Department of Laboratory of Pathology, Hospital Complex Santa Casa de Porto Alegre, University of Health Sciences of Porto Alegre Rio Grande do Sul, Brazil ; Neuroendocrinology Center, Hospital Complex Santa Casa de Porto Alegre, University of Health Sciences of Porto Alegre Rio Grande do Sul, Brazil.
authors.forename: Geraldine
authors.initials: G
authors.lastname: Trott
authors.affiliation: Department of Laboratory of Pathology, Hospital Complex Santa Casa de Porto Alegre, University of Health Sciences of Porto Alegre Rio Grande do Sul, Brazil ; Neuroendocrinology Center, Hospital Complex Santa Casa de Porto Alegre, University of Health Sciences of Porto Alegre Rio Grande do Sul, Brazil.
authors.forename: Taiana
authors.initials: T
authors.lastname: Haag
authors.affiliation: Neuroendocrinology Center, Hospital Complex Santa Casa de Porto Alegre, University of Health Sciences of Porto Alegre Rio Grande do Sul, Brazil.
authors.forename: Nelson Pires
authors.initials: NP
authors.lastname: Ferreira
authors.affiliation: Department of Laboratory of Pathology, Hospital Complex Santa Casa de Porto Alegre, University of Health Sciences of Porto Alegre Rio Grande do Sul, Brazil ; Neuroendocrinology Center, Hospital Complex Santa Casa de Porto Alegre, University of Health Sciences of Porto Alegre Rio Grande do Sul, Brazil.
authors.forename: Carolina Garcia Soares
authors.initials: CG
authors.lastname: Leães
authors.affiliation: Department of Laboratory of Pathology, Hospital Complex Santa Casa de Porto Alegre, University of Health Sciences of Porto Alegre Rio Grande do Sul, Brazil ; Neuroendocrinology Center, Hospital Complex Santa Casa de Porto Alegre, University of Health Sciences of Porto Alegre Rio Grande do Sul, Brazil.
authors.forename: Julia Fernanda Semmelmann
authors.initials: JF
authors.lastname: Pereira-Lima
authors.affiliation: Department of Laboratory of Pathology, Hospital Complex Santa Casa de Porto Alegre, University of Health Sciences of Porto Alegre Rio Grande do Sul, Brazil ; Neuroendocrinology Center, Hospital Complex Santa Casa de Porto Alegre, University of Health Sciences of Porto Alegre Rio Grande do Sul, Brazil.
authors.forename: Miriam da Costa
authors.initials: Mda C
authors.lastname: Oliveira
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D008579:Meningioma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D008875:Middle Aged; D011379:Prognosis; D017481:Receptors, Somatostatin / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; D017481:Receptors, Somatostatin
keywords: Immunohistochemistry; brain tumor; meningioma; receptors of somatostatin; recurrence; somatostatin