title: Neuronal Entropy-Rate Feature of Entopeduncular Nucleus in Rat Model of Parkinson's Disease.
abstract: The function of the nigro-striatal pathway on neuronal entropy in the basal ganglia (BG) output nucleus, i.e. the entopeduncular nucleus (EPN) was investigated in the unilaterally 6-hyroxydopamine (6-OHDA)-lesioned rat model of Parkinson's disease (PD). In both control subjects and subjects with 6-OHDA lesion of dopamine (DA) the nigro-striatal pathway, a histological hallmark for parkinsonism, neuronal entropy in EPN was maximal in neurons with firing rates ranging between 15 and 25 Hz. In 6-OHDA lesioned rats, neuronal entropy in the EPN was specifically higher in neurons with firing rates above 25 Hz. Our data establishes that the nigro-striatal pathway controls neuronal entropy in motor circuitry and that the parkinsonian condition is associated with abnormal relationship between firing rate and neuronal entropy in BG output nuclei. The neuronal firing rates and entropy relationship provide putative relevant electrophysiological information to investigate the sensory-motor processing in normal condition and conditions such as movement disorders.
authors.affiliation: 1 Department of Neurology, University South Alabama, 307 University Blvd., Mobile, AL 36688, USA.|2 Division of System Neurophysiology, National Institute for Physiological Sciences, Okazaki, 444-8585, Japan.|3 Animal Resource Program, University Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Olivier
authors.initials: O
authors.lastname: Darbin
authors.affiliation: 4 Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Xingxing
authors.initials: X
authors.lastname: Jin
authors.affiliation: 4 Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Christof
authors.initials: C
authors.lastname: Von Wrangel
authors.affiliation: 4 Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Schwabe
authors.affiliation: 2 Division of System Neurophysiology, National Institute for Physiological Sciences, Okazaki, 444-8585, Japan.|5 Department of Physiological Sciences, SOKENDAI (The Graduate University for Advanced Studies), Okazaki, 444-8585, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nambu
authors.affiliation: 1 Department of Neurology, University South Alabama, 307 University Blvd., Mobile, AL 36688, USA.
authors.forename: Dean K
authors.initials: DK
authors.lastname: Naritoku
authors.affiliation: 4 Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Joachim K
authors.initials: JK
authors.lastname: Krauss
authors.affiliation: 4 Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Mesbah
authors.initials: M
authors.lastname: Alam
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D020392:Entopeduncular Nucleus / Q000503:physiopathology*; D019277:Entropy; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D009474:Neurons / Q000502:physiology; D010300:Parkinson Disease / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
keywords: 6-OHDA; Entropy; basal ganglia; dopamine; globus pallidus internal; rat