title: Neurofibromatosis type 1 and cardiac manifestations.
abstract: OBJECTIVE
  Cardiac manifestations of neurofibromatosis type 1 (NF1) may include hypertension, congenital heart disease, and hypertrophic cardiomyopathy. The aim of this study was to evaluate cardiac abnormalities in patients with NF1.
  
  
  METHODS
  Sixty-five NF1 patients (mean age: 9±4.48 years) were retrospectively studied. Standard electrocardiography and echocardiography were performed in all patients.
  
  
  RESULTS
  Cardiac abnormalities were found in 11 of the 65 patients (15.3%). Five patients had mitral valve regurgitation, 2 patients had secundum atrial septal defect, 1 patient had pulmonary valvular stenosis, 1 patient had ventricular septal defect, 1 patient had tricuspid valve regurgitation, and 1 patient had aortic valve regurgitation.
  
  
  CONCLUSIONS
  Cardiac abnormalities have potential long-term hemodynamic consequences that justify an early diagnosis. Thus, for any patient with NF1, a cardiologic assessment is mandatory at the time of diagnosis and with regular follow-up intervals.
authors.affiliation: Department of Pediatric Neurology, Çukurova University Faculty of Medicine, Balcalı Hospital, Adana, Turkey. fincecik@gmail.com.
authors.forename: Faruk
authors.initials: F
authors.lastname: İncecik
authors.affiliation: Department of Pediatric Neurology, Çukurova University Faculty of Medicine, Balcalı Hospital, Adana, Turkey.
authors.forename: Özlem M
authors.initials: ÖM
authors.lastname: Hergüner
authors.affiliation: Department of Pediatric Cardiology, Çukurova University Faculty of Medicine, Balcalı Hospital, Adana, Turkey.
authors.forename: Sevcan
authors.initials: S
authors.lastname: Alınç Erdem
authors.affiliation: Department of Pediatric Neurology, Çukurova University Faculty of Medicine, Balcalı Hospital, Adana, Turkey.
authors.forename: Şakir
authors.initials: Ş
authors.lastname: Altunbaşak
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006331:Heart Diseases / Q000150:complications* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000453:epidemiology*; D012189:Retrospective Studies