title: The potential of food protein-derived anti-inflammatory peptides against various chronic inflammatory diseases.
abstract: Inflammation is considered as one of the major causes for the initiation of various chronic diseases such as asthma, cancer, cardiovascular disease, diabetes, obesity, inflammatory bowel disease, osteoporosis and neurological diseases like Parkinson's disease. Increasing scientific evidence has delineated that inflammatory markers such as TNF-α, IL-1, IL-6, IL-8 and CRP and different transcription factors such as NF-κB and STAT are the major key factors that regulate these inflammatory diseases. Food protein-derived bioactive peptides have been shown to exhibit anti-inflammatory activity by inhibiting or reducing the expression of these inflammatory biomarkers and/or by modulating the activity of these transcription factors. This review aims to discuss various molecular targets and underlying mechanisms of food protein-derived anti-inflammatory peptides and to explore their potential against various chronic inflammatory diseases. © 2015 Society of Chemical Industry.
authors.affiliation: Department of Agricultural, Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, AB, Canada.|Department of Food Science, University of Guelph, Guelph, ON, Canada.
authors.forename: Kaustav
authors.initials: K
authors.lastname: Majumder
authors.affiliation: Department of Food Science, University of Guelph, Guelph, ON, Canada.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Mine
authors.affiliation: Department of Agricultural, Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, AB, Canada.|Cardiovascular Research Centre, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
authors.forename: Jianping
authors.initials: J
authors.lastname: Wu
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D002908:Chronic Disease; D005504:Food Analysis; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D011506:Proteins / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011506:Proteins
keywords: atherosclerosis; bioactive peptides; chronic disease; food protein; inflammation; insulin resistance; obesity, anti-inflammatory activity; type 2 diabetes