title: Maintaining K+balance on the low-Na+, high-K+diet.
abstract: A low-Na+, high-K+diet (LNaHK) is considered a healthier alternative to the "Western" high-Na+diet. Because the mechanism for K+secretion involves Na+reabsorptive exchange for secreted K+in the distal nephron, it is not understood how K+is eliminated with such low Na+intake. Animals on a LNaHK diet produce an alkaline load, high urinary flows, and markedly elevated plasma ANG II and aldosterone levels to maintain their K+balance. Recent studies have revealed a potential mechanism involving the actions of alkalosis, urinary flow, elevated ANG II, and aldosterone on two types of K+channels, renal outer medullary K+and large-conductance K+channels, located in principal and intercalated cells. Here, we review these recent advances.
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon; and.
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Cornelius
authors.affiliation: Department of Cellular/Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Bangchen
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Cellular/Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang-France
authors.affiliation: Department of Cellular/Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska ssansom@unmc.edu.
authors.forename: Steven C
authors.initials: SC
authors.lastname: Sansom
mesh_terms: D000818:Animals; D004032:Diet; D006801:Humans; D017419:Potassium, Dietary / Q000378:metabolism*; D012982:Sodium, Dietary / Q000378:metabolism*
chemical_list: D017419:Potassium, Dietary; D012982:Sodium, Dietary
keywords: Na+-Cl− cotransporter; angiotensin II; epithelial Na+ channel; large-conductance K+ channel; renal outer medullary K+ channel