title: Low-Cost Interactive Image-Based Virtual Endoscopy for the Diagnosis and Surgical Planning of Suprasellar Arachnoid Cysts.
abstract: OBJECTIVE
  To investigate the feasibility and reliability of virtual endoscopy (VE) as a rapid, low-cost, and interactive tool for the diagnosis and surgical planning of suprasellar arachnoid cysts (SACs).
  
  
  METHODS
  Eighteen patients with SACs treated with endoscopic ventriculocystostomy were recruited, and 18 endoscopic patients treated with third ventriculostomy were randomly selected as a VE reconstruction control group. After loading their DICOM data into free 3D Slicer software, VE reconstruction was independently performed by 3 blinded clinicians and the time required for each reconstruction was recorded. Another 3 blinded senior neurosurgeons interactively graded the visibility of VE by watching video recordings of the endoscopic procedures. Based on the visibility scores, receiver operating characteristic curve analysis was used to investigate the reliability of VE to diagnose SACs, and Bland-Altman plots were used to assess the reliability of VE for surgical planning. In addition, the intraclass correlation coefficient was calculated to estimate the consistency among the results of 3 reconstruction performers.
  
  
  RESULTS
  All 3 independent reconstructing performers successfully completed VE simulation for all cases, and the average reconstruction time was 10.2 ± 9.7 minutes. The area under the receiver operating characteristic curve of the cyst visibility score was 0.96, implying its diagnostic value for SACs. The Bland-Altman plot indicated good agreement between VE and intraoperative viewings, suggesting the anatomic accuracy of the VE for surgical planning. In addition, the intraclass correlation coefficient was 0.81, which revealed excellent interperformer consistency of our simulation method.
  
  
  CONCLUSIONS
  This study substantiated the feasibility and reliability of VE as a rapid, low-cost, and interactive modality for diagnosis and surgical planning of SACs.
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China; School of Medicine, Nankai University, Tianjin, China; Surgical Planning Laboratory, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors.forename: Ye
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China; School of Medicine, Nankai University, Tianjin, China.
authors.forename: Yining
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
authors.forename: Jiashu
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
authors.forename: Guojun
authors.initials: G
authors.lastname: Dong
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
authors.forename: Xinguang
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
authors.forename: Bainan
authors.initials: B
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China. Electronic address: cxl73@msn.com.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D016080:Arachnoid Cysts; D001927:Brain Diseases; D002648:Child; D002675:Child, Preschool; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007223:Infant; D008297:Male; D011300:Preoperative Care; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014584:User-Computer Interface; D014696:Ventriculostomy / Q000401:mortality*; D055815:Young Adult
keywords: 3D Slicer; Suprasellar arachnoid cyst; Surgical planning; Virtual endoscopy