title: A case study of the neuropsychological outcomes following microsurgery, conventional radiotherapy and stereotactic radiotherapy for an adult's recurrent craniopharyngioma.
abstract: OBJECTIVE
  To examine the neuropsychological outcomes for an adult patient, 2 years after receiving microsurgery and conventional radiotherapy for a recurrent craniopharyngioma; and the impact of a further intervention, stereotactic radiotherapy, on this level of neuropsychological functioning.
  
  
  METHODS
  JD, a 30 year old male whose recurrent craniopharyngioma had 2 years earlier been treated with two operations and conventional radiotherapy.
  
  
  METHODS
  JD was assessed (using standardized clinical tests) before and after a course of stereotactic radiotherapy.
  
  
  RESULTS
  Prior to stereotactic radiotherapy (and 2 years after microsurgery and conventional radiotherapy) JD's IQ was intact, but considerable impairments were present in executive functioning, memory, theory of mind and processing speed. Fifteen months after stereotactic radiotherapy, all neuropsychological domains remained largely static or improved, supporting the utility of this treatment option in the neuropsychological domain. However, deficits in executive functioning, memory and processing speed remained.
  
  
  CONCLUSIONS
  These findings suggest that, even after multiple treatments, substantial cognitive impairments can be present in an adult patient with a recurrent craniopharyngioma. This profile of deficits underlines the inadequacy of relying purely on IQ as a marker for cognitive health in this population and emphasizes the need to include neuropsychological impairments as a focus of rehabilitation with these patients.
authors.affiliation: a School of Psychology and Social Science, Edith Cowan University , Perth WA , Australia.
authors.forename: David
authors.initials: D
authors.lastname: Preece
authors.affiliation: a School of Psychology and Social Science, Edith Cowan University , Perth WA , Australia.
authors.forename: Alfred
authors.initials: A
authors.lastname: Allan
authors.affiliation: a School of Psychology and Social Science, Edith Cowan University , Perth WA , Australia.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Becerra
mesh_terms: D000328:Adult; D060825:Cognitive Dysfunction / Q000209:etiology*; D003131:Combined Modality Therapy; D003397:Craniopharyngioma / Q000523:psychology* / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D056344:Executive Function; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D008866:Microsurgery / Q000379:methods; D009483:Neuropsychological Tests; D010911:Pituitary Neoplasms / Q000523:psychology* / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D011832:Radiation Injuries / Q000209:etiology; D016634:Radiosurgery / Q000379:methods*; D016896:Treatment Outcome
keywords: Executive functioning; intelligence; memory; neuropsychological; outcome; surgery