title: Premature subclinical atherosclerosis in children and young adults with juvenile idiopathic arthritis. A review considering preventive measures.
abstract: Many studies show that Juvenile Idiopathic Arthritis (JIA) is associated with early subclinical signs of atherosclerosis. Chronic inflammation per se may be an important driver but other known risk factors, such as dyslipidemia, hypertension, insulin insensitivity, a physically inactive lifestyle, obesity, and tobacco smoking may also contribute substantially. We performed a systematic review of studies through the last 20 years on early signs of subclinical atherosclerosis in children and adolescents with JIA with the purpose of investigating whether possible risk factors, other than inflammation, were considered.We found 13 descriptive cross sectional studies with healthy controls, one intervention study and two studies on adults diagnosed with JIA. Only one study addressed obesity, and physical activity (PA) has only been assessed in one study on adults with JIA and only by self-reporting. This is important as studies on PA in children with JIA have shown that most patients are less physically active than their healthy peers, and as physical inactivity in several large studies of normal schoolchildren is found to be associated with increased clustering of risk factors for cardiovascular disease. It is thus possible that an inactive lifestyle in patients with JIA is an important contributor to development of the subclinical signs of atherosclerosis seen in children with JIA, and that promotion of an active lifestyle in childhood and adolescence may diminish the risk for premature atherosclerotic events in adulthood.
authors.affiliation: Department of Paediatrics and Adolescent Medicine, JMC Research Unit, Rigshospitalet Afs. 7821, Tagensvej 22, DK 2200, Copenhagen N, Denmark. anna-helene.bohr@regionh.dk.
authors.forename: Anna-Helene
authors.initials: AH
authors.lastname: Bohr
authors.affiliation: Children's Hospital Boston, Boston, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Fuhlbrigge
authors.affiliation: Department of Paediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Freddy Karup
authors.initials: FK
authors.lastname: Pedersen
authors.affiliation: Children's Hospital Boston, Boston, USA.
authors.forename: Sarah D
authors.initials: SD
authors.lastname: de Ferranti
authors.affiliation: Department of Paediatrics and Adolescent Medicine, and Institute for Inflammation Research, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Klaus
authors.initials: K
authors.lastname: Müller
mesh_terms: D001171:Arthritis, Juvenile / Q000150:complications* / Q000503:physiopathology; D050197:Atherosclerosis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D002648:Child; D014943:Global Health; D006801:Humans; D015994:Incidence; D009043:Motor Activity; D012307:Risk Factors; D055815:Young Adult