title: Formal Gold- and Rhodium-Catalyzed Regiodivergent C-H Alkynylation of 2-Pyridones.
abstract: Formal regiodivergent C-H alkynylation of 2-pyridones bearing different N-substituents has been realized under Au(I) and Rh(III) catalysis using a hypervalent iodine alkyne reagent. When catalyzed by Au(I), the alkynylation occurred at the most electron-rich 5-position via an electrophilic alkynylation pathway. The selectivity was switched to the 6-position under assistance of an N-chelation group when a Rh(III) catalyst was employed. A rhodacylic complex has been isolated as a key intermediate.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Science , Dalian 116023, China.
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Science , Dalian 116023, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Xie
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Science , Dalian 116023, China.
authors.forename: Xingwei
authors.initials: X
authors.lastname: Li