title: The Effects of Hydrophilic Polyethylene Glycol-Based Adhesion Barrier Use to Prevent Intra-abdominal Adhesions in Intra-abdominal Sepsis Model.
abstract: Postoperative adhesion formation is still an important cause of morbidity and mortality. Hydrophilic polyethylene glycol-based adhesion barrier (SprayGel™, Confluent Surgical, Inc., Waltham, MA) is reported to prevent adhesion formation after gynecologic surgery. This study aims to determine the effectiveness of SprayGel™ on adhesion formation after laparotomy in an experimental septic peritonitis model. Wistar albino male rats with weights of 250-350 g were used in this study. Forty rats were grouped into four groups: group I (control), laparotomy and sham operation; group II, laparotomy and cecal ligation puncture (CLP); group III (SprayGel™), laparotomy, sham operation, and SprayGel™; group IV (CLP + SprayGel™), laparotomy, CLP, and SprayGel™. Intra-abdominal sepsis was achieved by perforating the cecum with a 26-gauge needle in selected groups. All animals were sacrificed after 10 days. The results were evaluated according to the score systems of Nair and Knightly. Kruskal-Wallis variance analysis was used for statistical analysis. There were significant differences for the development of adhesion between groups II (CLP) and III-IV (SprayGel™ - CLP + SprayGel™) (p < 0.02). Mortality and wound infection rates were significantly lower in the SprayGel™ treatment groups compared to control groups. Intraperitoneal administration of SprayGel™ significantly decreased the intraperitoneal adhesion formation, and it reduced mortality and wound infection as well.
authors.affiliation: Department of General Surgery, Faculty of Medicine, 19 Mayıs University, Samsun, Turkey.
authors.forename: Gökhan Selçuk
authors.initials: GS
authors.lastname: Ozbalci
authors.affiliation: Department of General Surgery, Faculty of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Marlen
authors.initials: M
authors.lastname: Sulaimanov
authors.affiliation: Department of General Surgery, Faculty of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Selçuk M
authors.initials: SM
authors.lastname: Hazinedaroğlu
authors.affiliation: Department of General Surgery, Faculty of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Attila
authors.initials: A
authors.lastname: Törüner
keywords: Bioabsorbable barrier; Hydrophilic polyethylene glycol (HPG); Intra-abdominal sepsis; Peritoneal adhesions; SprayGel™