title: Effect of Multiple Sclerosis Disease-Modifying Therapies on B Cells and Humoral Immunity.
abstract: The unequivocal success of B-cell-depleting agents in reducing magnetic resonance imaging and clinical activity in therapeutic trials indicates that B cells play a vital role in mediating the clinical course of relapsing multiple sclerosis (MS). Although no agent that specifically targets B cells has yet been approved for clinical use, all existing disease-modifying therapies (DMTs) for MS modulate B-cell immunity to some degree. This review examines the effects of MS DMTs on B-cell immunity. Most MS DMTs induced a relative decrease in circulating memory B cells with concomitant expansion of circulating B-cell precursors and/or naive B cells. B-cell function was also altered; most DMTs induced B-cell production of the anti-inflammatory cytokine interleukin 10 while inhibiting B-cell expression of proinflammatory cytokines. The commonalities in the effects of approved DMTs on B-cell phenotype and function among treated patients with MS are striking and suggest that effects on B cells underlie part of their efficacy. More complete understanding of how the existing DMTs modulate B-cell immunity may identify future targets for therapeutic intervention.
authors.affiliation: Department of Neurology, Washington University, St Louis, Missouri.
authors.forename: Erin E
authors.initials: EE
authors.lastname: Longbrake
authors.affiliation: Department of Neurology, Washington University, St Louis, Missouri.
authors.forename: Anne H
authors.initials: AH
authors.lastname: Cross
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D056724:Immunity, Humoral / Q000187:drug effects* / Q000276:immunology; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D009103:Multiple Sclerosis / Q000188:drug therapy*; D012008:Recurrence
chemical_list: D016207:Cytokines; D007166:Immunosuppressive Agents