title: Short Communication: Preferential Killing of HIV Latently Infected CD4(+) T Cells by MALT1 Inhibitor.
abstract: We report that the addition of an host paracaspase MALT1 inhibitor, MI-2, to HIV latently infected ACH-2, Jurkat E4, and J-LAT cells accelerated cell death in the presence of cell stimuli or the protein kinase C agonist, bryostatin 1. MI-2-mediated cell death correlated with the induction of the cellular RNase MCPIP1 and requires the presence of viral component(s). Altogether, the combination of MI-2 and bryostatin 1 displays selective killing of HIV latently infected CD4(+) T cells.
authors.affiliation: 1 Research Institute of Medicine and Pharmacy, Qiqihar Medical University , Qiqihar, China .|2 Bioscience Division, Center for Immunology and Infectious Diseases, SRI International , Harrisonburg, Virginia.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Li
authors.affiliation: 3 Department of Basic Medical Science, School of Medicine, University of Missouri-Kansas City , Kansas City, Missouri.
authors.forename: Hui
authors.initials: H
authors.lastname: He
authors.affiliation: 4 Biosciences Division, Center for Chemical Biology, SRI International , Menlo Park, California.
authors.forename: Leyi
authors.initials: L
authors.lastname: Gong
authors.affiliation: 3 Department of Basic Medical Science, School of Medicine, University of Missouri-Kansas City , Kansas City, Missouri.
authors.forename: Mingui
authors.initials: M
authors.lastname: Fu
authors.affiliation: 2 Bioscience Division, Center for Immunology and Infectious Diseases, SRI International , Harrisonburg, Virginia.
authors.forename: Tony T
authors.initials: TT
authors.lastname: Wang
mesh_terms: D000083:Acetanilides / Q000494:pharmacology*; D054713:Bryostatins / Q000494:pharmacology*; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects* / Q000821:virology; D020169:Caspases / Q000378:metabolism; D045744:Cell Line, Tumor; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D019169:Jurkat Cells; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012260:Ribonucleases / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014230:Triazoles / Q000494:pharmacology*; D014775:Virus Activation / Q000187:drug effects; D017735:Virus Latency; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000083:Acetanilides; D054713:Bryostatins; C000612169:MI-2 acetamide; D009363:Neoplasm Proteins; D014157:Transcription Factors; D014230:Triazoles; C046785:bryostatin 1; D012260:Ribonucleases; C510646:ZC3H12A protein, human; D020169:Caspases; C400109:MALT1 protein, human; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein