title: Crossed cerebellar diaschisis after stroke identified noninvasively with cerebral blood flow-weighted arterial spin labeling MRI.
abstract: OBJECTIVE
  Crossed cerebellar diaschisis (CCD) is most commonly investigated using hemodynamic PET and SPECT imaging. However, noninvasive MRI offers advantages of improved spatial resolution, allowing hemodynamic changes to be compared directly with structural findings and without concerns related to ionizing radiation exposure. The aim of this study was to evaluate relationships between CCD identified from cerebral blood flow (CBF)-weighted arterial spin labeling (ASL) MRI with cerebrovascular reactivity (CVR)-weighted blood oxygenation level dependent (BOLD) MRI, Wallerian degeneration, clinical motor impairment, and corticospinal tract involvement.
  
  
  METHODS
  Subjects (n=74) enrolled in an ongoing observational stroke trial underwent CBF-weighted ASL and hypercapnic CVR-weighted BOLD MRI. Hemispheric asymmetry indices for basal cerebellar CBF, cerebellar CVR, and cerebral peduncular area were compared between subjects with unilateral supratentorial infarcts (n=18) and control subjects without infarcts (n=16). CCD required (1) supratentorial infarct and (2) asymmetric cerebellar CBF (>95% confidence interval relative to controls).
  
  
  RESULTS
  In CCD subjects (n=9), CVR (p=0.04) and cerebral peduncular area (p<0.01) were significantly asymmetric compared to controls. Compared to infarct subjects not meeting CCD criteria (n=9), CCD subjects had no difference in corticospinal tract location for infarct (p=1.0) or motor impairment (p=0.08).
  
  
  CONCLUSIONS
  CCD correlated with cerebellar CVR asymmetry and Wallerian degeneration. These findings suggest that noninvasive MRI may be a useful alternative to PET or SPECT to study structural correlates and clinical consequences of CCD following supratentorial stroke.
authors.affiliation: Department of Radiology and Radiological Sciences, Vanderbilt Medical Center, Nashville, TN, USA.
authors.forename: Megan K
authors.initials: MK
authors.lastname: Strother
authors.affiliation: Department of Radiology and Radiological Sciences, Vanderbilt Medical Center, Nashville, TN, USA.
authors.forename: Cari
authors.initials: C
authors.lastname: Buckingham
authors.affiliation: Department of Radiology and Radiological Sciences, Vanderbilt Medical Center, Nashville, TN, USA.
authors.forename: Carlos C
authors.initials: CC
authors.lastname: Faraco
authors.affiliation: Department of Radiology and Radiological Sciences, Vanderbilt Medical Center, Nashville, TN, USA.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Arteaga
authors.affiliation: Center for Quantitative Sciences, Vanderbilt Medical Center, Nashville, TN, USA.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Lu
authors.affiliation: Center for Quantitative Sciences, Vanderbilt Medical Center, Nashville, TN, USA.
authors.forename: Yaomin
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Radiology and Radiological Sciences, Vanderbilt Medical Center, Nashville, TN, USA. Electronic address: mj.donahue@vanderbilt.edu.
authors.forename: Manus J
authors.initials: MJ
authors.lastname: Donahue
mesh_terms: D002545:Brain Ischemia / Q000150:complications / Q000473:pathology*; D002526:Cerebellar Diseases / Q000473:pathology*; D002531:Cerebellum / Q000098:blood supply / Q000473:pathology*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D013113:Spin Labels; D020521:Stroke / Q000209:etiology / Q000473:pathology*
chemical_list: D013113:Spin Labels
keywords: BOLD; CBF; Cerebrovascular reactivity; Crossed cerebellar diaschisis; Wallerian degeneration; fMRI