title: Sarcoidosis and Aspergillosis: case presentation.
abstract: Sarcoidosis is a multisystemic inflammatory disease of unknown etiology, characterized by noncaseous epithelioid cell granulomas. The evolution of the disease may be complicated by opportunistic infections such as aspergillosis, that usually appears in type IV sarcoidosis. We present the case of a 74 year-old women with a history of sarcoidosis for over 7 years, who presented for hemoptysis. She was diagnosed with pulmonary cavitary aspergillosis and treatment with ltraconazole was initiated. The patient was monitored every two months. At the one year follow up, the patient was asymptomatic, with a good treatment tolerance and no decline in lung function, despite the pulmonary fibrosis. The sputum exams continued to be positive for Aspergillus, the HRCT-scan described a chronic pulmonary aspergillosis. The antifungical treatment was continued, under careful monitoring. The patient remained asymptomatic with no further decline in lung volumes. The particularity of the case consists in the lack of symptoms, despite pulmonary fibrosis, and the therapeutic challenges of chronic pulmonary aspergillosis.
authors.forename: Bianca
authors.initials: B
authors.lastname: Paraschiv
authors.forename: Anne-Charlotte
authors.initials: AC
authors.lastname: Sellier
authors.forename: Camelia
authors.initials: C
authors.lastname: Diaconu
authors.forename: Rèmy
authors.initials: R
authors.lastname: Bernard
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001230:Aspergillus / Q000302:isolation & purification*; D005260:Female; D006469:Hemoptysis / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000627:therapeutic use; D009894:Opportunistic Infections / Q000150:complications* / Q000188:drug therapy; D055732:Pulmonary Aspergillosis / Q000150:complications* / Q000188:drug therapy; D012507:Sarcoidosis / Q000150:complications*; D013183:Sputum / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole