title: Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B.
abstract: We report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-threatening adverse events and resulted in rapid and sustained clinical and parasitological cure.
authors.affiliation: Plateforme ICAReB, Institut Pasteur, Paris, France.
authors.forename: Gloria
authors.initials: G
authors.lastname: Morizot
authors.affiliation: Service d'anesthésie-réanimation, Hôpital Necker, Paris, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Jouffroy
authors.affiliation: Service de Pédiatrie générale, Hôpital Robert Debré, Paris, France.
authors.forename: Albert
authors.initials: A
authors.lastname: Faye
authors.affiliation: Service de Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Lyon, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Chabert
authors.affiliation: Service de Maladies Infectieuses et Tropicales, Hôpital Pitié-Salpêtrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Katia
authors.initials: K
authors.lastname: Belhouari
authors.affiliation: Service de Maladies Infectieuses et Tropicales, Hôpital Pitié-Salpêtrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Ruxandra
authors.initials: R
authors.lastname: Calin
authors.affiliation: Université Paris Descartes, Centre d'Infectiologie Necker-Pasteur, Hôpital Necker-Enfants malades, IHU Imagine, Paris, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Charlier
authors.affiliation: Service de Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Lyon, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Miailhes
authors.affiliation: Service d'Accueil des Urgences pédiatriques, Hôpital Robert Debré, Paris, France.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Siriez
authors.affiliation: Service de Parasitologie-Mycologie, Hôpital Pitié-Salpêtrière, Paris, France.
authors.forename: Oussama
authors.initials: O
authors.lastname: Mouri
authors.affiliation: Service de Parasitologie-Mycologie. Hôpital Cochin, Faculté de Médecine, Paris Descartes, Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Yera
authors.affiliation: Université Paris Descartes, Centre d'Infectiologie Necker-Pasteur, Hôpital Necker-Enfants malades, IHU Imagine, Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Gilquin
authors.affiliation: Service de Maladies Infectieuses et Tropicales, Hôpital Pitié-Salpêtrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Roland
authors.initials: R
authors.lastname: Tubiana
authors.affiliation: Université Paris Descartes, Centre d'Infectiologie Necker-Pasteur, Hôpital Necker-Enfants malades, IHU Imagine, Paris, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Lanternier
authors.affiliation: Service de transplantation rénale, Hôpital Necker, Paris, France.
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Mamzer
authors.affiliation: Service de transplantation rénale, Hôpital Necker, Paris, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Legendre
authors.affiliation: Service de Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Lyon, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Peyramond
authors.affiliation: Service de Maladies Infectieuses et Tropicales, Hôpital Pitié-Salpêtrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Caumes
authors.affiliation: Université Paris Descartes, Centre d'Infectiologie Necker-Pasteur, Hôpital Necker-Enfants malades, IHU Imagine, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
authors.affiliation: Service de Parasitologie-Mycologie, Hôpital Pitié-Salpêtrière, Paris, France.|945 INSERM, Université Paris 6, Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Buffet
mesh_terms: D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use*; D000965:Antimony / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D007893:Leishmania donovani / Q000187:drug effects*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B; D000965:Antimony