title: [Obesity as a risk factor in the development of cancer].
abstract: According to the World Health Organization, every year about 3.4 million adults die of consequences related to overweight or obesity. People with a Body Mass Index above 30 are more likely to express certain diseases, including some types of cancer. In this narrative review, we assess the role of adipose tissue as a modulator of the endocrine system and facilitator of chronic subclinical inflammation. We discuss how obesity can induce a suitable micro environment for the development of tumors, mainly by enhancing the levels of oxidative stress and the concentrations of hormones such as leptin, insulin and prolactin. We conclude that all together, these factors increase the probability of cancer development.
authors.affiliation: Centro de Investigaciones Cerebrales, Universidad Veracruzana, Veracruz, México.
authors.forename: Deissy
authors.initials: D
authors.lastname: Herrera-Covarrubias
authors.affiliation: Centro de Investigaciones Cerebrales, Universidad Veracruzana, Veracruz, México.
authors.forename: Genaro Alfonso
authors.initials: GA
authors.lastname: Coria-Avila
authors.affiliation: Centro de Investigaciones Cerebrales, Universidad Veracruzana, Veracruz, México.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Fernández-Pomares
authors.affiliation: Centro de Investigaciones Cerebrales, Universidad Veracruzana, Veracruz, México.
authors.forename: Gonzalo E
authors.initials: GE
authors.lastname: Aranda-Abreu
authors.affiliation: Centro de Investigaciones Cerebrales, Universidad Veracruzana, Veracruz, México.
authors.forename: Jorge
authors.initials: J
authors.lastname: Manzo Denes
authors.affiliation: Centro de Investigaciones Cerebrales, Universidad Veracruzana, Veracruz, México.
authors.forename: María Elena
authors.initials: ME
authors.lastname: Hernández
mesh_terms: D000273:Adipose Tissue; D006801:Humans; D020738:Leptin; D009369:Neoplasms / Q000453:epidemiology*; D009765:Obesity; D012307:Risk Factors
chemical_list: D020738:Leptin