title: Total Synthesis of Gelsenicine via a Catalyzed Cycloisomerization Strategy.
abstract: The first total synthesis of (±)-gelsenicine is reported. The synthetic route is highly efficient (13 steps), featuring (1) a pivotal metal-catalyzed isomerization/rearrangement process that forges the central core of the molecule and (2) two facile C-N bond-forming steps that establish the flanking heterocycles.
authors.affiliation: Department of Chemistry, University of Georgia , Athens, Georgia 30602, United States.
authors.forename: Eric T
authors.initials: ET
authors.lastname: Newcomb
authors.affiliation: Department of Chemistry, University of Georgia , Athens, Georgia 30602, United States.
authors.forename: Phil C
authors.initials: PC
authors.lastname: Knutson
authors.affiliation: Department of Chemistry, University of Georgia , Athens, Georgia 30602, United States.
authors.forename: Blaine A
authors.initials: BA
authors.lastname: Pedersen
authors.affiliation: Department of Chemistry, University of Georgia , Athens, Georgia 30602, United States.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Ferreira
mesh_terms: D002384:Catalysis; D003500:Cyclization; D026121:Indole Alkaloids / Q000138:chemical synthesis*; D007536:Isomerism
chemical_list: D026121:Indole Alkaloids; C571027:gelsenicine