title: Merkel cell carcinoma of the eyelid. A series of 5 cases and review of the literature.
abstract: OBJECTIVE
  Presentation of 5 clinical cases of Merkel cell carcinoma of the eyelid, highlighting the clinical, histopathological, management, and monitoring features. Review of related literature.
  
  
  METHODS
  Retrospective review of clinical records and telephone interview of the 5 patients treated for Merkel cell carcinoma between 2006 and 2013, in the Orbit and Oculoplastic Department, Clinical Hospital of the University of Chile.
  
  
  RESULTS
  Five patients (2 men, 3 women); 79.2 years (range 64-94 years), with a mean onset of 10 weeks (range 5-16 weeks), tumour size reaching a mean of 2.5×2×2.1cm at the time of surgery. Described as a nodular mass, exophytic, solid, reddish coloured. With no infiltrated lymph nodes or metastases in the first match. Staging as T2N0M0, after the first surgery with oncological criteria. Two lymph node recurrences detected during monitoring. Distant metastasis was found in one patient. The histopathological diagnosis was confirmed by immunohistochemical study of the biopsy. The surgical strategy was full excision, control of surgical margins in the intraoperative period, and eyelid reconstruction with Hughes flap, Cutler/Beard flap or primary closure, depending on the case.
  
  
  CONCLUSIONS
  Early diagnosis, wide excision of the tumour with intraoperative control of clear margins with conventional or Mohs surgery, and proper eyelid reconstruction are adequate for a good survival in elderly patients with this eyelid tumour. The study of sentinel lymph node biopsy in primary intervention is recommended; with subsequent radiotherapy to decrease the recurrence and increase survival.
authors.affiliation: Servicio de Oftalmología, Hospital Clínico de la Universidad de Chile J.J. Aguirre, Santiago, Chile. Electronic address: benjaminriesco@gmail.com.
authors.forename: B
authors.initials: B
authors.lastname: Riesco
authors.affiliation: Servicio de Oftalmología, Hospital Clínico de la Universidad de Chile J.J. Aguirre, Santiago, Chile.
authors.forename: N
authors.initials: N
authors.lastname: Cárdenas
authors.affiliation: Servicio de Oftalmología, Hospital del Salvador, Santiago, Chile.
authors.forename: V
authors.initials: V
authors.lastname: Sáez
authors.affiliation: Servicio de Oftalmología, Hospital Clínico de la Universidad de Chile J.J. Aguirre, Santiago, Chile.
authors.forename: G
authors.initials: G
authors.lastname: Torres
authors.affiliation: Servicio de Anatomía Patológica, Hospital Clínico Universidad de Chile, J.J. Aguirre, Santiago, Chile.
authors.forename: I
authors.initials: I
authors.lastname: Gallegos
authors.affiliation: Servicio de Oftalmología, Hospital Clínico de la Universidad de Chile J.J. Aguirre, Santiago, Chile.
authors.forename: J
authors.initials: J
authors.lastname: Dassori
authors.affiliation: Servicio de Oftalmología, Hospital Clínico de la Universidad de Chile J.J. Aguirre, Santiago, Chile.
authors.forename: N
authors.initials: N
authors.lastname: Saldías
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015266:Carcinoma, Merkel Cell / Q000175:diagnosis / Q000628:therapy; D005142:Eyelid Neoplasms / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies
keywords: Carcinoma neuroendocrino; Células de Merkel; Eyelid; Ganglio centinela; Immunohistochemistry; Inmunohistoquímica; Merkel cells; Neuroendocrine carcinoma; Párpado; Sentinel lymph node