title: Acaricidal activity of Asarum heterotropoides root-derived compounds and hydrodistillate constitutes toward Dermanyssus gallinae (Mesostigmata: Dermanyssidae).
abstract: The acaricidal activity of Asarum heterotropoides root-derived principles, methyleugenol, safrole, 3-carene, α-asarone, pentadecane and A. heterotropoides root steam distillate constituents was tested against poultry red mites Dermanyssus gallinae (De Geer). All active principles were identified by spectroscopic analysis. Results were compared with those of two conventional acaricides, benzyl benzoate and N,N-diethyl-3-methylbenzamide (DEET). Methyleugenol (24 h LC50 = 0.57 µg/cm(2)) and safrole (24 h LC50 = 8.54 µg/cm(2)) were the most toxic compounds toward D. gallinae, followed by 3,4,5-trimethoxytoluene, 3,5-dimethoxytoluene, estragole, α-terpineol, verbenone, eucarvone, linalool, and terpinen-4-ol (LC50 = 15.65-27.88 µg/cm(2)). Methyleugenol was 16.7× and 11.0× more toxic than benzyl benzoate (LC50 = 9.52 μg/cm(2)) and DEET (LC50 = 6.28 μg/cm(2)), respectively; safrole was 1.1× and 0.73× more toxic. Asarum heterotropoides root-derived materials, particularly methyleugenol and safrole, merit further study as potential acaricides. Global efforts to reduce the level of highly toxic synthetic acaricides in indoor environments justify further studies on A. heterotropoides root extract and steam distillate preparations containing the active constituents described as potential contact-action fumigants for the control of mites.
authors.affiliation: Crop Protection Division, Department of Agro-food Safety and Crop Protection, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, 565-851, Republic of Korea. jr2004@korea.kr.
authors.forename: Jun-Ran
authors.initials: JR
authors.lastname: Kim
authors.affiliation: Research Institute for Agriculture and Life Science, Seoul National University, Seoul, 151-921, South Korea.
authors.forename: Haribalan
authors.initials: H
authors.lastname: Perumalsamy
authors.affiliation: Crop Protection Division, Department of Agro-food Safety and Crop Protection, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, 565-851, Republic of Korea.
authors.forename: Ju-Hee
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Research Institute for Agriculture and Life Science, Seoul National University, Seoul, 151-921, South Korea.
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Ahn
authors.affiliation: Gyeonggi Agricultural Research and Extension Services, Hwaseong, 445-784, Republic of Korea.
authors.forename: Young Su
authors.initials: YS
authors.lastname: Lee
authors.affiliation: Crop Protection Division, Department of Agro-food Safety and Crop Protection, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, 565-851, Republic of Korea.
authors.forename: Sang-Guie
authors.initials: SG
authors.lastname: Lee
mesh_terms: D056810:Acaricides / Q000737:chemistry; D000818:Animals; D030023:Asarum / Q000737:chemistry*; D002645:Chickens / Q000469:parasitology; D008925:Mites / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry
chemical_list: D056810:Acaricides; D010936:Plant Extracts
keywords: Asarum heterotropoides; Botanical acaricide; Dermanyssus gallinae; Methyleugenol; Poultry red mites