title: In-Vivo Higher Plasma Levels of Platelet-Derived Growth Factor and Matrix Metalloproteinase-9 in Coronary Artery at the Very Onset of Myocardial Infarction with ST-Segment Elevation.
abstract: OBJECTIVE
  Platelet-derived growth factor (PDGF) induces matrix metalloproteinase (MMP), which is regarded as a biomarker of plaque rupture or vulnerability. The aim of this study is to investigate those interactions in human coronary arteries at the onset of ST-segment elevation myocardial infarction (STEMI).
  
  
  METHODS
  Thirty-two patients with STEMI who underwent primary percutaneous coronary intervention (PCI) were enrolled in this study. Plasma levels of PDGF-BB and MMP-9 were measured from infarct-related artery (IRA) and from femoral artery (FA) during PCI.
  
  
  RESULTS
  Plasma levels of PDGF-BB and MMP-9 in the IRA were significantly higher than those in the FA (PDGF-BB: median 3130 pg/ml, IQR (interquartile range): 2020 to 4375 pg/ml vs. median 2605 pg/ml, IQR: 1305 to 3290 pg/ml, p <0.01, MMP-9: median 49 ng/ml, IQR: 35 to 100 ng/ml vs. median 42 ng/ml, IQR: 27 to 78 ng/ml, p = 0.04, IRA and FA, respectively).
  
  
  CONCLUSIONS
  This in vivo study demonstrated that PDGF-BB with MMP-9 seems to play a role in coronary plaque instability in acute phase of STEMI.
authors.affiliation: Department of Cardiovascular Medicine, Saitama International Medical Center, Saitama Medical University, Hidaka, Saitama, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Koizumi
authors.affiliation: Department of Cardiovascular Medicine, Saitama International Medical Center, Saitama Medical University, Hidaka, Saitama, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Komiyama
authors.affiliation: Department of Cardiovascular Medicine, Saitama International Medical Center, Saitama Medical University, Hidaka, Saitama, Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Nishimura
keywords: coronary artery plaque; myocardial infarction; platelet-derived mediator