title: Migraine and its psychiatric comorbidities.
abstract: Migraine is a highly prevalent and disabling neurological disorder associated with a wide range of psychiatric comorbidities. In this manuscript, we provide an overview of the link between migraine and several comorbid psychiatric disorders, including depression, anxiety and post-traumatic stress disorder. We present data on psychiatric risk factors for migraine chronification. We discuss the evidence, theories and methods, such as brain functional imaging, to explain the pathophysiological links between migraine and psychiatric disorders. Finally, we provide an overview of the treatment considerations for treating migraine with psychiatric comorbidities. In conclusion, a review of the literature demonstrates the wide variety of psychiatric comorbidities with migraine. However, more research is needed to elucidate the neurocircuitry underlying the association between migraine and the comorbid psychiatric conditions and to determine the most effective treatment for migraine with psychiatric comorbidity.
authors.affiliation: Department of Neurology, NYU Langone Medical Center, New York, New York, USA.
authors.forename: Mia Tova
authors.initials: MT
authors.lastname: Minen
authors.affiliation: Department of Internal Medicine, NYU Langone Medical Center, New York, New York, USA.
authors.forename: Olivia
authors.initials: O
authors.lastname: Begasse De Dhaem
authors.affiliation: Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Medical Center, Cincinnati, Ohio, USA.
authors.forename: Ashley
authors.initials: A
authors.lastname: Kroon Van Diest
authors.affiliation: Cincinnati Children's Medical Center, Headache Center, Office for Clinical and Translational Research, Center for Child Behavior and Nutrition Research and Training, Pediatrics, Cincinnati, Ohio, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Powers
authors.affiliation: Department of Neurology, Mayo Clinic, Phoenix, USA.
authors.forename: Todd J
authors.initials: TJ
authors.lastname: Schwedt
authors.affiliation: Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Lipton
authors.affiliation: Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors.forename: David
authors.initials: D
authors.lastname: Silbersweig
mesh_terms: D002908:Chronic Disease; D015897:Comorbidity; D006801:Humans; D001523:Mental Disorders / Q000453:epidemiology* / Q000523:psychology* / Q000628:therapy; D008881:Migraine Disorders / Q000453:epidemiology* / Q000523:psychology* / Q000628:therapy; D012307:Risk Factors
keywords: MIGRAINE; NEUROEPIDEMIOLOGY; NEUROPSYCHIATRY; NEURORADIOLOGY; PSYCHOPHARMACOLOGY