title: Serum Levels of Monocyte Chemoattractant Protein-1 Correlate with Poor Clinical Grades in Cerebral Aneurysms.
abstract: BACKGROUND
  Ruptured cerebral aneurysms (ICAs) are the most common non-traumatic cause of subarachnoid hemorrhage (SAH) that is associated with life threatening complications such as Vasospasm, Infarction, and Hydrocephalus (HCP). The active participation of macrophage/monocyte-mediated inflammatory response in the pathogenesis of cerebral aneurysm as labeled with Monocyte Chemoattractant Protein-1 (MCP-1) is suggested.
  
  
  OBJECTIVE
  To measure the serum level of MCP-1 in ruptured CAs in different time intervals.
  
  
  METHODS
  We measured the serum levels of MCP-1 in SAH patients who had CAs and compared it with that of MCP-1 in two control groups: including patients with SAH without CAs, and the normal population of blood donors. We also measured the MCP-1 levels in patients with CAs one week afterward to evaluate the effect of treatment. Serum level of MCP-1 was measured by a commercial ELISA assay.
  
  
  RESULTS
  Mean serum MCP-1 level in patients with SAH and CAs was 188.2168 Pg/ml and 331.3982 Pg/ml in the normal population. There was no statistically significant difference between serum levels of MCP-1 on the first (mean=188.2168 Pg/ml) and 7th days after SAH onset (mean=171.8450 Pg/ml) (p=0.739). Serum level of MCP-1 increased significantly as Glasgow Coma Scale decreased (p=0.078) and Hunt and Hess score increased (p=0.089).
  
  
  CONCLUSIONS
  Our results did not show an increasing MCP-1 serum level in patients with aneurysmal SAH. There was a relationship between poor clinical grade and MCP-1 levels in patients with CAs. MCP-1 may be a local inflammatory marker for cerebral aneurysms without systemic manifestation.
authors.affiliation: Department of Neurosurgery, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran, e-mail:ak.rahmanian@gmail.com.
authors.forename: Abdolkarim
authors.initials: A
authors.lastname: Rahmanian
authors.forename: Navideh
authors.initials: N
authors.lastname: Mohebali
authors.forename: Ali
authors.initials: A
authors.lastname: Haghnegahdar
authors.forename: Eskandar
authors.initials: E
authors.lastname: Kamali Sarvestani
authors.forename: Ali
authors.initials: A
authors.lastname: Razmkon
authors.forename: Juri
authors.initials: J
authors.lastname: Kivelev
authors.forename: Fahim
authors.initials: F
authors.lastname: Baghban
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood*; D018450:Disease Progression; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; C111835:CCL2 protein, human; D018932:Chemokine CCL2