title: Muscle-specific microRNAs in skeletal muscle development.
abstract: Proper muscle function constitutes a precondition for good heath and an active lifestyle during an individual's lifespan and any deviations from normal skeletal muscle development and its functions may lead to numerous health conditions including e.g. myopathies and increased mortality. It is thus not surprising that there is an increasing need for understanding skeletal muscle developmental processes and the associated molecular pathways, especially as such information could find further uses in therapy. The understanding of complex skeletal muscle developmental networks was broadened with the discovery of microRNA (miRNA) molecules. MicroRNAs are evolutionary conserved small non-coding RNAs capable of negatively regulating gene expression on a post-transcriptional level by means of miRNA-mRNA interaction. Several miRNAs expressed exclusively in muscle have been labeled myomiRs. MyomiRs represent an integral part of skeletal muscle development, i.e. playing a significant role during skeletal muscle proliferation, differentiation and regeneration. The purpose of this review is to provide a summary of current knowledge regarding the involvement of myomiRs in the individual phases of myogenesis and other aspects of skeletal muscle biology, along with an up-to-date list of myomiR target genes and their functions in skeletal muscle and miRNA-related therapeutic approaches and future prospects.
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic. Electronic address: 376148@mail.muni.cz.
authors.forename: Martin
authors.initials: M
authors.lastname: Horak
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic; Department of Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic. Electronic address: jnmedved@seznam.cz.
authors.forename: Jan
authors.initials: J
authors.lastname: Novak
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic; Research Centre for Toxic Compounds in the Environment, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic. Electronic address: Vasku.Julie@seznam.cz.
authors.forename: Julie
authors.initials: J
authors.lastname: Bienertova-Vasku
mesh_terms: D000818:Animals; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000196:embryology* / Q000378:metabolism
chemical_list: C544547:MIRN1 microRNA, human; C548234:MIRN133 microRNA, human; C546087:MIRN206 microRNA, human; C560945:MIRN486 microRNA, human; C548683:MIRN499 microRNA, human; D035683:MicroRNAs
keywords: miR-1; miR-133; miR-206; miR-208b; miR-486; miR-499