title: THE SEARCH OF COMPOUNDS WITH ANTIAGGREGATION ACTIVITY AMONG S-ESTERS OF THIOSULFONIC ACIDS.
abstract: According to the current understanding, the hyperactivation of platelets may lead to increased intravascular coagulation and thrombosis. Today a relevant issue is the search for new anti-thrombotic agents that are able to modulate the activity of platelet receptors, thus, influence the processes of activation and aggregation of platelets. The aim of this study was to investigate the effects of newly synthesized thiosulfonate derivatives on platelet aggregation. The activity of the compounds was tested in vitro using platelet-rich plasma. As a result of the screening test, structural formulas of four agents with high antiaggregative activity were established. These compounds inhibited ADP- and collagen-induced platelet aggregation in a dose-dependent manner. Two of these compounds were shown to be more effective inhibitors of aggregation induced by ADP (IC50 - 8-10 μM), as well as collagen (IC50 - 1.5-2.0 μM).
authors.forename: T I
authors.initials: TI
authors.lastname: Halenova
authors.forename: I V
authors.initials: IV
authors.lastname: Nikolaeva
authors.forename: A V
authors.initials: AV
authors.lastname: Nakonechna
authors.forename: K B
authors.initials: KB
authors.lastname: Bolibrukh
authors.forename: N Y
authors.initials: NY
authors.lastname: Monka
authors.forename: V I
authors.initials: VI
authors.lastname: Lubenets
authors.forename: O M
authors.initials: OM
authors.lastname: Savchuk
authors.forename: V P
authors.initials: VP
authors.lastname: Novikov
authors.forename: L I
authors.initials: LI
authors.lastname: Ostapchenko
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D055808:Drug Discovery; D004952:Esters; D015394:Molecular Structure; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D053657:Platelet-Rich Plasma / Q000166:cytology; D011817:Rabbits; D013329:Structure-Activity Relationship; D013886:Thiosulfonic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004952:Esters; D010975:Platelet Aggregation Inhibitors; D013886:Thiosulfonic Acids