title: Mutual sensitization mechanism and self-degradation property of drug delivery system for in vitro photodynamic therapy.
abstract: In this manuscript, a photosensitive anti-cancer drug, hypocrellin A (HA), and TiO2 nanoparticles were co-loaded on the surface of graphene oxide (GO) as a photosensitive drug delivery system. In vitro studies have demonstrated the active uptake of the system into the mitochondrial of tumor cells. Such system has mutual sensitization mechanism to greatly improve the reactive oxygen species (ROSs) generation ability of the complex by visible light irradiation and, thereby, the strong photodynamic therapy (PDT) efficacy. Furthermore, during such PDT process, GO can be destroyed by the ROSs, which would helpful for the metabolism of this drug delivery system.
authors.affiliation: College of Chemistry and Materials Science, Analysis and Testing Centre, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ding
authors.affiliation: College of Chemistry and Materials Science, Analysis and Testing Centre, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China. Electronic address: zhoulin@njnu.edu.cn.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: College of Chemistry and Materials Science, Analysis and Testing Centre, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: College of Chemistry and Materials Science, Analysis and Testing Centre, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wu
authors.affiliation: College of Chemistry and Materials Science, Analysis and Testing Centre, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Ziyi
authors.initials: Z
authors.lastname: Song
authors.affiliation: College of Chemistry and Materials Science, Analysis and Testing Centre, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Wei
authors.affiliation: College of Chemistry and Materials Science, Analysis and Testing Centre, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China. Electronic address: zhoujiahong@njnu.edu.cn.
authors.forename: Jiahong
authors.initials: J
authors.lastname: Zhou
authors.affiliation: College of Chemistry and Materials Science, Analysis and Testing Centre, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems / Q000379:methods*; D006367:HeLa Cells; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species
keywords: Cancer; Graphene oxide; Hypocrellin A; Mutual sensitization; Self-degradation; TiO(2)