title: A new coumarin from stem bark of Mesua hexapetala.
abstract: A new alkylated coumarin derivative, hexapetarin (1) along with three other xanthones, trapezifolixanthone (2), cudraxanthone G (3) and 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone (4), and four common triterpenoids, friedelin (5), stigmasterol (6), beta-sitosterol (7) and gamma-sitosterol (8) were isolated from the stem bark of Mesua hexapetala (Clusiaceae), a plant, native to Malaysia. The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. Anti-inflammatory activity assay indicated hexapetarin (1) to possess moderate anti-inflammatory activity, while 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone (4) gave very good activity.
authors.affiliation: a Faculty of Science, Department of Chemistry , Universiti Putra Malaysia , Serdang , Malaysia.
authors.forename: Thiruventhan
authors.initials: T
authors.lastname: Karunakaran
authors.affiliation: a Faculty of Science, Department of Chemistry , Universiti Putra Malaysia , Serdang , Malaysia.
authors.forename: Gwendoline Cheng Lian
authors.initials: GC
authors.lastname: Ee
authors.affiliation: a Faculty of Science, Department of Chemistry , Universiti Putra Malaysia , Serdang , Malaysia.
authors.forename: Soek Sin
authors.initials: SS
authors.lastname: Teh
authors.affiliation: a Faculty of Science, Department of Chemistry , Universiti Putra Malaysia , Serdang , Malaysia.|b Faculty of Applied Science , Universiti Teknologi MARA , Jengka , Malaysia.
authors.forename: Shaari
authors.initials: S
authors.lastname: Daud
authors.affiliation: c School of Biosciences , Taylor's University , Subang Jaya , Malaysia.
authors.forename: Siau Hui
authors.initials: SH
authors.lastname: Mah
authors.affiliation: d Faculty of Science, Department of Chemical Sciences , Universiti Tunku Abdul Rahman , Kampar , Malaysia.
authors.forename: Chan Kiang
authors.initials: CK
authors.lastname: Lim
authors.affiliation: e Centre of Applied Science Studies , Universiti Teknologi MARA , Kuching , Malaysia.
authors.forename: Vivien Yi Mian
authors.initials: VY
authors.lastname: Jong
authors.affiliation: f Faculty of Science, Department of Chemistry , University of Malaya , Kuala Lumpur , Malaysia.
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002478:Cells, Cultured; D028084:Clusiaceae / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008296:Malaysia; D013058:Mass Spectrometry; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003374:Coumarins; D010936:Plant Extracts; C000617282:hexapetarin
keywords: Mesua hexapetala; anti-inflammatory; coumarin; xanthone