title: A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model.
abstract: The first off-on probe, Mito-TRFS, for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells was reported. In a cellular model of Parkinson's disease (PD), Mito-TRFS staining discloses a drastic decline of the TrxR2 activity, providing a mechanistic link of TrxR2 dysfunction to the etiology of PD.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. fangjg@lzu.edu.cn.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. fangjg@lzu.edu.cn.
authors.forename: Huilong
authors.initials: H
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. fangjg@lzu.edu.cn.
authors.forename: Liangwei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. fangjg@lzu.edu.cn.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Cui
authors.affiliation: State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. fangjg@lzu.edu.cn.
authors.forename: Xiaoting
authors.initials: X
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. fangjg@lzu.edu.cn.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Fang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008928:Mitochondria / Q000201:enzymology*; D015335:Molecular Probes; D010300:Parkinson Disease / Q000201:enzymology*; D013880:Thioredoxin-Disulfide Reductase / Q000378:metabolism*
chemical_list: D015335:Molecular Probes; D013880:Thioredoxin-Disulfide Reductase