title: One-pot Synthesis of Metal-Organic Frameworks with Encapsulated Target Molecules and Their Applications for Controlled Drug Delivery.
abstract: Many medical and chemical applications require target molecules to be delivered in a controlled manner at precise locations. Metal-organic frameworks (MOFs) have high porosity, large surface area, and tunable functionality and are promising carriers for such purposes. Current approaches for incorporating target molecules are based on multistep postfunctionalization. Here, we report a novel approach that combines MOF synthesis and molecule encapsulation in a one-pot process. We demonstrate that large drug and dye molecules can be encapsulated in zeolitic imidazolate framework (ZIF) crystals. The molecules are homogeneously distributed within the crystals, and their loadings can be tuned. We show that ZIF-8 crystals loaded with the anticancer drug doxorubicin (DOX) are efficient drug delivery vehicles in cancer therapy using pH-responsive release. Their efficacy on breast cancer cell lines is higher than that of free DOX. Our one-pot process opens new possibilities to construct multifunctional delivery systems for a wide range of applications.
authors.affiliation: Berzelii Center EXSELENT on Porous Materials, Department of Materials and Environmental Chemistry, Stockholm University , SE-106 91 Stockholm, Sweden.
authors.forename: Haoquan
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Institute of Environmental Medicine, Karolinska Institutet , SE-171 77 Stockholm, Sweden.
authors.forename: Yuning
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Berzelii Center EXSELENT on Porous Materials, Department of Materials and Environmental Chemistry, Stockholm University , SE-106 91 Stockholm, Sweden.
authors.forename: Leifeng
authors.initials: L
authors.lastname: Liu
authors.affiliation: Berzelii Center EXSELENT on Porous Materials, Department of Materials and Environmental Chemistry, Stockholm University , SE-106 91 Stockholm, Sweden.
authors.forename: Wei
authors.initials: W
authors.lastname: Wan
authors.affiliation: Berzelii Center EXSELENT on Porous Materials, Department of Materials and Environmental Chemistry, Stockholm University , SE-106 91 Stockholm, Sweden.
authors.forename: Peng
authors.initials: P
authors.lastname: Guo
authors.affiliation: Institute of Environmental Medicine, Karolinska Institutet , SE-171 77 Stockholm, Sweden.
authors.forename: Andreas M
authors.initials: AM
authors.lastname: Nyström
authors.affiliation: Berzelii Center EXSELENT on Porous Materials, Department of Materials and Environmental Chemistry, Stockholm University , SE-106 91 Stockholm, Sweden.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zou
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D005434:Flow Cytometry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008264:Macrophages / Q000187:drug effects; D018613:Microscopy, Confocal; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010316:Particle Size; D013329:Structure-Activity Relationship; D013499:Surface Properties; D017641:Zeolites / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D009942:Organometallic Compounds; D017641:Zeolites; D004317:Doxorubicin