title: Activation of the ventral and dorsal striatum during cue reactivity in Internet gaming disorder.
abstract: Studies conducted in drug addiction suggest a transition in processing of drug-related cues from the ventral to the dorsal component of the striatum. However, this process has not been studied in a behavioral addiction. Assessment of this process in a non-drug addiction can provide insight into the pathophysiology of both substance and behavioral addictions. Thirty-nine male Internet gaming disorder (IGD) subjects and 23 male matched healthy controls (HCs) participated in functional magnetic resonance imaging during performance of a cue-reactivity task involving alternating presentation of Internet gaming-related stimuli (game cues) and general Internet surfing-related stimuli (control cues). Cue-induced neural activations in the ventral and dorsal striatum (DS) were compared between IGD and HC participants. Associations between cue-reactivity within these regions and cue-induced craving and severity and duration of IGD were also explored. IGD participants exhibited higher cue-induced activations within both the ventral and DS when compared with HCs. Within the IGD group, activity within the left ventral striatum (VS) was correlated negatively with cue-induced craving; positive associations were found between activations within the DS (right putamen, pallidum and left caudate) and duration of IGD. Cue-induced activity within the left putamen was negatively associated with right VS volumes among IGD participants. Consistent with studies in substance addictions, our results suggest that a transition from ventral to dorsal striatal processing may occur among individuals with IGD, a condition without the impact of substance intake.
authors.affiliation: Institute of Developmental Psychology, Beijing Normal University, Beijing, 100875, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06519, USA.|CASA Columbia, Yale University School of Medicine, New Haven, CT, 06519, USA.
authors.forename: Sarah W
authors.initials: SW
authors.lastname: Yip
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, 100875, China.
authors.forename: Jin-Tao
authors.initials: JT
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
authors.forename: Ling-Jiao
authors.initials: LJ
authors.lastname: Wang
authors.affiliation: Institute of Developmental Psychology, Beijing Normal University, Beijing, 100875, China.
authors.forename: Zi-Jiao
authors.initials: ZJ
authors.lastname: Shen
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
authors.forename: Ben
authors.initials: B
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
authors.forename: Yuan-Wei
authors.initials: YW
authors.lastname: Yao
authors.affiliation: Institute of Developmental Psychology, Beijing Normal University, Beijing, 100875, China.
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Fang
mesh_terms: D000328:Adult; D016739:Behavior, Addictive / Q000503:physiopathology*; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003463:Cues; D006801:Humans; D020407:Internet; D008297:Male; D066328:Ventral Striatum / Q000000981:diagnostic imaging / Q000503:physiopathology; D018910:Video Games; D055815:Young Adult
keywords: Internet gaming disorder; cue-reactivity; dorsal striatum; fMRI; ventral striatum