title: [Role of glomerular mesangial cell in the pathogenetic progress of lupus nephritis fibrosis].
abstract: OBJECTIVE
  To explore the roles of proliferative lesions of mesangial cell and reactive oxygen species (ROS) in the pathogenetic progress of lupus nephritis fibrosis.
  
  
  METHODS
  Control mice C57BL/6 and model mice NZBWF1 were selected. Kidney tissues were collected for hematoxylin and eosin (HE) and Masson staining at Week 8, 12 and 16. The proliferation of glomerular cells was assessed by BrdU incorporation light microscopy. And the expression of NOX4 protein was detected by Western blot.
  
  
  RESULTS
  HE and Masson staining showed that model mice began to develop interstitial fibrosis and worsened at Weeks 12 and 16. The numbers of mesangial cell increased at Week 8 and became prominent at Weeks 12 and 16. The expression of NOX4 protein increased with the progression of lupus nephritis fibrosis.
  
  
  CONCLUSIONS
  Glomerular mesangial cell and ROS play an role in the pathogenetic progress of lupus nephritis fibrosis.
authors.affiliation: Beijing Children's Hospital, Capital Medical University, Beijing 100045, China; Email: caifeng_li@yeah.net.
authors.forename: Caifeng
authors.initials: C
authors.lastname: Li
authors.affiliation: Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Shipeng
authors.initials: S
authors.lastname: Li
authors.affiliation: Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Junmei
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Tan
authors.affiliation: Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Jianghong
authors.initials: J
authors.lastname: Deng
authors.affiliation: Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yan
mesh_terms: D000818:Animals; D015153:Blotting, Western; D018450:Disease Progression; D005355:Fibrosis; D007678:Kidney Glomerulus; D008181:Lupus Nephritis; D050527:Mesangial Cells; D051379:Mice; D008810:Mice, Inbred C57BL; D008814:Mice, Inbred NZB