title: Mismatch repair and homeologous recombination.
abstract: DNA mismatch repair influences the outcome of recombination events between diverging DNA sequences. Here we discuss how mismatch repair proteins are active in different homologous recombination subpathways and specific reaction steps, resulting in differential modulation of these recombination events, with a focus on the mechanism of heteroduplex rejection during the inhibition of recombination between slightly diverged (homeologous) DNA sequences.
authors.affiliation: Department of Genetics, Cancer Genomics Netherlands, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Khek-Chian
authors.initials: KC
authors.lastname: Tham
authors.affiliation: Department of Genetics, Cancer Genomics Netherlands, Erasmus MC, Rotterdam, The Netherlands; Department of Radiation Oncology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Roland
authors.initials: R
authors.lastname: Kanaar
authors.affiliation: Department of Genetics, Cancer Genomics Netherlands, Erasmus MC, Rotterdam, The Netherlands; Department of Radiation Oncology, Erasmus MC, Rotterdam, The Netherlands. Electronic address: j.lebbink@erasmusmc.nl.
authors.forename: Joyce H G
authors.initials: JHG
authors.lastname: Lebbink
mesh_terms: D000818:Animals; D053843:DNA Mismatch Repair; D004261:DNA Replication; D059765:Homologous Recombination; D006801:Humans; D008954:Models, Biological; D009692:Nucleic Acid Heteroduplexes
chemical_list: D009692:Nucleic Acid Heteroduplexes
keywords: Antirecombination; Heteroduplex rejection; Homeologous recombination; Homologous recombination; Mismatch repair