title: [ Mitochondrial DNA polymorphism association with myocardial infarction and prognostic signs for atherosclerosis].
abstract: We have performed association analysis for mtDNA most common variants and haplogroups with myocardial infarction and some prognostic characteristics in patients. Comparison of patients (N=406) and controls (N=183) has shown higher frequency of HV0 haplogroup in patients (6.9% vs. 2.2%; p=0.033). Patients with early infarction (before age 55), comparing to patiens older than 55 and the first infarction, had higher frequency of 16189C variant (24.1 vs. 12.5%; p=0.008); also, haplogroup U2e was registered only in the subgroup with early infarction (4.4%; p=0.004). On the other side, haplogroup U5 was less frequent in the patients with early infarction (5.1% vs. 15.4%; p=0.002). The patients with recurring cardiovascular incidents during one year follow-up had higher frequency of haplogroup H1 (20% versus 4.5% in the patients without complications, p=0.002) and variant 16189C (30% versus 13.5%; p=0.018). Haplogroup U5 was more frequent in the group of patients with left ventricular ejection fraction less than 40%: 17.1% comparing to 8.2% in the group with ejection fraction>40%; p=0.034. The results suggest that mtDNA polymorphism contributes to coronary atherosclerosis. The associations could be explained by the polymorphism effect on oxidative phosphorylation and reactive oxygen production in mitochondria.
authors.affiliation: Research Institute for Medical Genetics, Tomsk, 634050 Russia;|Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, 650002 Russia.|National Research Tomsk State University, Tomsk, 634050 Russia.|maria.golubenko@medgenetics.ru.
authors.forename: M V
authors.initials: MV
authors.lastname: Golubenko
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, 650002 Russia.
authors.forename: R R
authors.initials: RR
authors.lastname: Salakhov
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, 650002 Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Makeeva
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, 650002 Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Goncharova
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, 650002 Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Kashtalap
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, 650002 Russia.
authors.forename: O L
authors.initials: OL
authors.lastname: Barbarash
authors.affiliation: Research Institute for Medical Genetics, Tomsk, 634050 Russia;
authors.forename: V P
authors.initials: VP
authors.lastname: Puzyrev
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000235:genetics*; D016022:Case-Control Studies; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D004272:DNA, Mitochondrial
keywords: genetic polymorphism; mitochondrial DNA; myocardial infarction