title: Plexiform myxoid gastrointestinal stromal tumor: a potential diagnostic pitfall in pathological findings.
abstract: Gastrointestinal stromal tumors (GISTs) have a rather wide morphologic spectrum. Here, we report a rare variant plexiform GIST in gastric antrum. Microscopically, the tumor showed plexiform or multinodular growth pattern, proliferation of spindle cells, presence of epithelioid cells, and abundant myxoid stroma with thin-walled blood vessels. The histologic features were similar to plexiform fibromyxoma. The typical characteristics of immunohistochemistry (positive for CD34, DOG-1 and CD117) confirmed the final diagnosis of GIST. This is a rare case of myxoid GIST characterized by a plexiform growth pattern.
authors.affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University Shenyang 110004, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Pathology, College of Basic Medical Sciences and The First Affiliated Hospital of China Medical University Shenyang 110001, People's Republic of China.
authors.forename: Qing-Fu
authors.initials: QF
authors.lastname: Zhang
authors.affiliation: Department of Breast Surgery, The First Affiliated Hospital of China Medical University Shenyang 110001, People's Republic of China.
authors.forename: Yu-Nan
authors.initials: YN
authors.lastname: Han
authors.affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University Shenyang 110004, People's Republic of China.
authors.forename: Ling
authors.initials: L
authors.lastname: Ouyang
mesh_terms: D000368:Aged; D000075369:Anoctamin-1; D018952:Antigens, CD34 / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018118:Chloride Channels / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000473:pathology* / Q000601:surgery; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D009363:Neoplasm Proteins / Q000378:metabolism; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: C476213:ANO1 protein, human; D000075369:Anoctamin-1; D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D018118:Chloride Channels; D009363:Neoplasm Proteins; D019009:Proto-Oncogene Proteins c-kit
keywords: Gastrointestinal stromal tumors; c-KIT mutation; plexiform fibromyxoma