title: Biological activity of a polypeptide modulator of TRPV1 receptor.
abstract: This paper presents data on the activity of a new APHC2 polypeptide modulator of TRPV1 receptors, which was isolated from the sea anemone Heteractis crispa. It has been shown that APHC2 has an analgesic activity, does not impair normal motor activity, and does not change body temperature of experimental animals, which has a great practical value for design of potent analgesics of a new generation. Further study of the characteristics of binding of the polypeptide to the TRPV1 receptor may show approaches to the development of other antagonists of this receptor that do not influence the body temperature.
authors.affiliation: Pushchino Branch, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow oblast, 142292, Russia. dyachenko@bibch.ru.
authors.forename: I A
authors.initials: IA
authors.lastname: Dyachenko
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117871, Russia. ay@land.ru.
authors.forename: Ya A
authors.initials: YA
authors.lastname: Andreev
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117871, Russia.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Logashina
authors.affiliation: Pushchino Branch, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow oblast, 142292, Russia. murashev@bibch.ru.
authors.forename: A N
authors.initials: AN
authors.lastname: Murashev
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117871, Russia. grev@ibch.ru.
authors.forename: E V
authors.initials: EV
authors.lastname: Grishin
mesh_terms: D000700:Analgesics / Q000008:administration & dosage* / Q000378:metabolism; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002211:Capsaicin / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects; D010146:Pain / Q000188:drug therapy* / Q000378:metabolism; D010455:Peptides / Q000008:administration & dosage* / Q000378:metabolism; D011485:Protein Binding; D012615:Sea Anemones / Q000737:chemistry; D050916:TRPV Cation Channels / Q000378:metabolism*
chemical_list: D000700:Analgesics; D010455:Peptides; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; D002211:Capsaicin