title: Fibroids: Genotype and Phenotype.
abstract: Fibroids represent a major public health care problem as the most prevalent pelvic tumors in women of reproductive age and as the leading cause of gynecologic surgeries in the United States. The recent advances in the genomic technologies including genome-wide association studies and high-throughput sequencing provide insight into their pathogenesis and molecular classification. Understanding the molecular basis of fibroids may facilitate development of effective targeted treatment options of this very common disease.
authors.affiliation: *Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital †Department of Pathology, Massachusetts General Hospital ‡Harvard Medical School, Boston, Massachusetts.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Ordulu
mesh_terms: D024141:Collagen Type IV / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D044127:Epigenesis, Genetic; D054890:Fatty Acid Synthase, Type I / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D024003:HMGA Proteins / Q000235:genetics; D051548:Histone Acetyltransferases / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D007889:Leiomyoma / Q000235:genetics*; D056892:Mediator Complex / Q000235:genetics; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics; D010641:Phenotype; D012097:Repressor Proteins / Q000235:genetics; D014157:Transcription Factors; D014594:Uterine Neoplasms / Q000235:genetics*
chemical_list: C478159:COL4A5 protein, human; C559044:COL4A6 protein, human; C080632:CUX1 protein, human; D024141:Collagen Type IV; D004268:DNA-Binding Proteins; D024003:HMGA Proteins; D018398:Homeodomain Proteins; C460107:MED12 protein, human; D056892:Mediator Complex; D009687:Nuclear Proteins; C413002:RAD51B protein, human; D012097:Repressor Proteins; D014157:Transcription Factors; D051548:Histone Acetyltransferases; C487137:KAT6B protein, human; C518729:FASN protein, human; D054890:Fatty Acid Synthase, Type I