title: Withania somnifera: From prevention to treatment of cancer.
abstract: The identification of bioactive molecules that have potential to interrupt carcinogenesis continues to garner research interest. In particular, molecules that have dietary origin are most attractive because of their safety, cost-effectiveness and feasibility of oral administration. Nutraceuticals have played an important role in the overall well-being of humans for many years, with or without rigorous evidence backing their health claims. Traditional medicine systems around the world have utilized plants that have medicinal properties for millennia, providing an opportunity for modern day researchers to assess their efficacies against ailments such as cancer. Withania somnifera (WS) is a plant that has been used in Ayurveda (an ancient form of medicine in Asia) and in the recent past, has been demonstrated to have anti-tumorigenic properties in experimental models. While scientific research performed on WS has exploded in the past decade, much regarding the mode of action and molecular targets involved remains unknown. In this review, we discuss the traditional uses of the plant, the experimental evidence supporting its chemopreventive potential as well as roadblocks that need to be overcome in order for WS to be evaluated as a chemopreventive agent in humans.
authors.affiliation: Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Dushani L
authors.initials: DL
authors.lastname: Palliyaguru
authors.affiliation: Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Shivendra V
authors.initials: SV
authors.lastname: Singh
authors.affiliation: Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.|Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Kensler
mesh_terms: D000818:Animals; D001208:Asia; D045744:Cell Line, Tumor; D018890:Chemoprevention; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008515:Medicine, Ayurvedic; D009369:Neoplasms / Q000188:drug therapy* / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D032341:Withania / Q000737:chemistry*; D054358:Withanolides / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D054358:Withanolides; C009684:withaferin A
keywords: Ayurveda; Cancer; Chemoprevention; Nutraceuticals; Withaferin A; Withania somnifera