title: Intersession test-retest variability of conventional and novel parameters using the MP-1 microperimeter.
abstract: OBJECTIVE
  To investigate the intersession test-retest variability (TRV) of topography- and threshold-based parameters derived from the Nidek MP-1.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  Sixteen participants with and without central scotoma underwent microperimetry in one eye over three sessions at 1-month intervals in a single institution. We calculated 95% coefficient of repeatability (CR) for the number of normal-suspect (NS) loci, relative scotoma (RS) and dense scotoma (DS), median macular sensitivity (MS), mean sensitivity of responding loci (RLS), perilesional loci (PLS), and extralesional loci (ELS). Topographical agreement score of mapping NS and DS loci (TASNS and TASDS) were also calculated for each patient.
  
  
  RESULTS
  Mean (range) age was 50 (21-86) years. The CR (95% confidence intervals) for NS, RS, and DS were 9.9 (6.5-13.3), 9.5 (6.2-12.7), and 3.0 (1.1-4.1) respectively. CR (95% CIs) for median MS, mean RLS, PLS, and ELS were 3.4 (2.3-4.5), 1.6 (1.1-2.2), 1.8 (0.9-2.6), and 2.8 (1.5-4.0) dB. We found significant change in thresholds between Test 1, and Tests 2 and 3 (both P=0.03), but not between Tests 2 and 3 (P=0.8). Medians (range) TASNS and TASDS were 74% (39%-100%) and 77% (0%-97%), respectively, between Tests 2 and 3.
  
  
  CONCLUSIONS
  We recommend the use of four DS loci (upper limit of CR) as the limit of TRV for assessing change. There was large interindividual variability in NS or DS mapping agreement. We recommend discarding the first microperimetry test and caution the use of a change in spatial distribution to determine disease progression.
authors.affiliation: Centre for Ophthalmology and Visual Science, (Lions Eye Institute), The University of Western Australia, Perth, WA, Australia.
authors.forename: Evan N
authors.initials: EN
authors.lastname: Wong
authors.affiliation: Centre for Ophthalmology and Visual Science, (Lions Eye Institute), The University of Western Australia, Perth, WA, Australia.
authors.forename: David A
authors.initials: DA
authors.lastname: Mackey
authors.affiliation: Centre for Ophthalmology and Visual Science, (Lions Eye Institute), The University of Western Australia, Perth, WA, Australia; Department of Ophthalmology, Royal Perth Hospital, Perth, WA, Australia.
authors.forename: William H
authors.initials: WH
authors.lastname: Morgan
authors.affiliation: Centre for Ophthalmology and Visual Science, (Lions Eye Institute), The University of Western Australia, Perth, WA, Australia; Department of Ophthalmology, Royal Perth Hospital, Perth, WA, Australia.
authors.forename: Fred Kuanfu
authors.initials: FK
authors.lastname: Chen
keywords: Nidek MP-1; TASDS; TASNS; test–retest variability