title: Associations of Toll-like receptor 7 and 8 Polymorphisms with Asthma and Asthma-related Phenotypes in a Chinese Han Population.
abstract: Toll-like receptor (TLR) 7 and 8 mediate anti-virus immunity and are of particular relevance to asthma. However, very little information about genetic association on TLR7/8 and asthma are available. This study aimed to evaluate the effects of polymorphisms in TLR7 and 8 on asthma risk and asthma-related phenotypes in a Chinese Han population. We enrolled 462 unrelated adult asthmatic patients and 398 healthy volunteers. The genotypes of tagging single nucleotide polymorphisms (SNPs) in TLR7 and 8 genes were determined using multiplex SNaPshot SNP genotyping assay. We used case-control and case-only studies to assess any links with asthma and asthma-related phenotypes. There was no association between the variants in TLR7 and 8 and asthma susceptibility. However, our results revealed that the genetic variants in TLR7 and 8 were associated with asthma-related phenotypes, including eosinophil counts, serum immunoglobulin E levels, lung function, and asthma severity as well. Our study suggests that TLR7 and 8 polymorphisms may play a considerable role in the pathogenesis of asthma. It will help in better understanding the pathogenesis of asthma and development of more effective strategies for asthma prevention, prediction, and therapy.
authors.affiliation: Department of Respiratory Medicine, Affiliated Changzhou No.2 People's Hospital, Nanjing Medical University, Changzhou, China AND Department of Respiratory Medicine, Nanjing General Hospital of Nanjing Military Command, Nanjing, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Affiliated Jiangbing Hospital, Jiangsu University, Zhenjiang, China.
authors.forename: Fen-Hong
authors.initials: FH
authors.lastname: Qian
authors.affiliation: Department of Respiratory Medicine, Affiliated Changzhou No.2 People's Hospital, Nanjing Medical University, Changzhou, China.
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Yin
authors.affiliation: Department of Respiratory Medicine, Affiliated Changzhou No.2 People's Hospital, Nanjing Medical University, Changzhou, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Cao
authors.affiliation: Department of epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
authors.forename: Jian-Ling
authors.initials: JL
authors.lastname: Bai
authors.affiliation: Department of Respiratory Medicine, Second Affiliated Hospital, Nanjing Medical University, Nanjing , China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Du
authors.affiliation: Department of Respiratory Medicine, Nanjing General Hospital of Nanjing Military Command, Nanjing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D051199:Toll-Like Receptor 7 / Q000235:genetics*; D051200:Toll-Like Receptor 8 / Q000235:genetics*
chemical_list: C495348:TLR7 protein, human; C495349:TLR8 protein, human; D051199:Toll-Like Receptor 7; D051200:Toll-Like Receptor 8
keywords: Allergy; Asthma; Genotype; Polymorphism; Toll-like receptor 7 and 8