title: Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity.
abstract: BACKGROUND
  Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity.
  
  
  OBJECTIVE
  The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects.
  
  
  METHODS
  Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity.
  
  
  RESULTS
  The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls.
  
  
  CONCLUSIONS
  The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.
authors.affiliation: a Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Mardan-Nik
authors.affiliation: b Department of Modern Sciences and Technologies , School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.|c Division of Applied Medicine , Medical School, University of Aberdeen , Foresterhill , Aberdeen , UK.
authors.forename: Alireza
authors.initials: A
authors.lastname: Pasdar
authors.affiliation: d Department of Medical Biotechnology , School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.|e Biotechnology Research Center, Mashhad University of Medical Sciences , Mashhad , Iran.
authors.forename: Khadijeh
authors.initials: K
authors.lastname: Jamialahmadi
authors.affiliation: b Department of Modern Sciences and Technologies , School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Avan
authors.affiliation: a Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Mohebati
authors.affiliation: f Department of Biostatistics and Epidemiology , School of Health, Mashhad University of Medical Sciences , Mashhad , Iran.
authors.forename: Habibollah
authors.initials: H
authors.lastname: Esmaily
authors.affiliation: g Department of Biochemistry , Golestan University , Gorgan , Iran.
authors.forename: Atefeh
authors.initials: A
authors.lastname: Biabangard-Zak
authors.affiliation: h Student Research Committee, Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Afzal Javan
authors.affiliation: h Student Research Committee, Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Rivandi
authors.affiliation: i Brighton & Sussex Medical School, Division of Medical Education , Falmer , Brighton , Sussex , UK.
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Ferns
authors.affiliation: j Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D009765:Obesity / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D018840:HSP70 Heat-Shock Proteins; C525621:HSPA1B protein, human
keywords: Obesity; PCR-RFLP; coronary artery disease; heat shock protein 70; polymorphism