title: Mixed model of dietary fat effect on postprandial glucose-insulin metabolism from carbohydrates in type 1 diabetes.
abstract: In this study we introduce an extension of a previously developed model of glucose-insulin metabolism in type 1 diabetes (T1D) from carbohydrates that includes the effect of dietary fat on postprandial glycemia. We include two compartments that represent plasma triglyceride and nonesterified fatty acid (NEFA) concentration, in addition to a mathematical representation of delayed gastric emptying and insulin resistance, which are the most well-known effects of dietary fat metabolism. Simulation results show that postprandial glucose as well as lipid levels in our model approximates clinical data from T1D patients.
authors.forename: Claudia Cecilia
authors.initials: CC
authors.lastname: Yamamoto Noguchi
authors.forename: Noriaki
authors.initials: N
authors.lastname: Kunikane
authors.forename: Shogo
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Eiko
authors.initials: E
authors.lastname: Furutani
mesh_terms: D001786:Blood Glucose; D003922:Diabetes Mellitus, Type 1; D004041:Dietary Fats; D005947:Glucose; D006801:Humans; D007328:Insulin; D019518:Postprandial Period; D014280:Triglycerides
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D014280:Triglycerides; D005947:Glucose