title: Synthesis and biological evaluation of novel dioxa-bicycle C-aryl glucosides as SGLT2 inhibitors.
abstract: A series of novel C-aryl glucosides containing dioxa-bicycle were synthesized and evaluated for inhibition activity against hSGLT2. Among the compounds tested, compound 6a showed moderate SGLT2 inhibition activities at 700 nM. The results could benefit the discovery of new SGLT2 inhibitors.
authors.affiliation: School of Pharmacy, Fudan University, Shanghai 201203, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Yan
authors.affiliation: School of Pharmacy, Fudan University, Shanghai 201203, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Ding
authors.affiliation: School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address: liyx417@fudan.edu.cn.
authors.forename: Yingxia
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D016466:CHO Cells; D003412:Cricetulus; D005960:Glucosides / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015394:Molecular Structure; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D013329:Structure-Activity Relationship
chemical_list: D005960:Glucosides; D007004:Hypoglycemic Agents; C089180:SLC5A2 protein, human; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors
keywords: C-aryl glucosides; Diabetes; SGLT2