title: Dedifferentiated Chondrosarcoma of the Larynx.
abstract: Primary dedifferentiated chondrosarcoma occurring in the larynx is a rare head and neck malignancy. The cases reported in the literature suggest male gender predilection and variable clinical outcomes ranging from disease-free survival to disease-related death. Although a calcified matrix is suggestive of chondrosarcoma, the dedifferentiated component is not readily appreciated on conventional imaging modalities and thorough tissue sampling is necessary for confirming the diagnosis. Histologically, there is an abrupt transition from a well-differentiated chondrosarcoma to a high-grade spindle cell component, which can show focal heterologous differentiation. These features are exemplified in this sine qua non radiology-pathology correlation article.
authors.affiliation: Department of Pathology, The University of Chicago, Chicago, IL, USA. shiraz.fidai@uchospitals.edu.
authors.forename: Shiraz S
authors.identifier: http://orcid.org/0000-0001-8063-5046
authors.initials: SS
authors.lastname: Fidai
authors.affiliation: Department of Radiology, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA.
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Ginat
authors.affiliation: Department of Otolaryngology, Vanderbilt University, Nashville, TN, USA.
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Langerman
authors.affiliation: Department of Pathology, The University of Chicago, Chicago, IL, USA.
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Cipriani
mesh_terms: D001859:Bone Neoplasms / Q000473:pathology*; D002454:Cell Differentiation; D002813:Chondrosarcoma / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged
keywords: Cricoid cartilage; Head and neck malignancy; Heterologous differentiation; Larynx; Primary dedifferentiated chondrosarcoma; Well-differentiated chondrosarcoma