title: Herpes simplex virus type-1: replication, latency, reactivation and its antiviral targets.
abstract: Infection by herpes simplex virus type-1 (HSV-1) causes several diseases, ranging from cutaneous, oral and genital infections to fatal encephalitis. Despite the availability of antiviral therapies on the market, their efficacies are incomplete, and new cases of resistant strains arise, mainly in the immunocompromised, but also recently documented in immunocompetent patients. Over the last decades a lot has been discovered about the molecular basis of infection which has been of great benefit to the investigation of new anti-HSV-1 molecules. In this review we summarize replication, latency and reactivation highlighting potential antiviral targets and new molecules described in the past several years in the literature.
authors.affiliation: Department of Cellular and Molecular Biology, Universidade Federal Fluminense, Biology Institute, Niterói, Brazil.
authors.forename: Camilly P
authors.initials: CP
authors.lastname: Pires de Mello
authors.forename: David C
authors.initials: DC
authors.lastname: Bloom
authors.forename: Izabel Cnp
authors.initials: IC
authors.lastname: Paixão
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006561:Herpes Simplex / Q000188:drug therapy* / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D017735:Virus Latency / Q000502:physiology*; D014779:Virus Replication / Q000502:physiology*
chemical_list: D000998:Antiviral Agents