title: RISK OF RHEGMATOGENOUS RETINAL DETACHMENT WITH CENTRAL SEROUS CHORIORETINOPATHY.
abstract: OBJECTIVE
  To investigate the risk of rhegmatogenous retinal detachment (RRD) after central serous chorioretinopathy (CSCR).
  
  
  METHODS
  The study included 2,830 patients with CSCR and 16,980 control patients matched using a propensity score for age, sex, and comorbidities including status after cataract operation, blunt trauma, myopia, diabetes mellitus, hypertension, and hyperlipidemia from January 2001 through December 2010 from the Taiwan Longitudinal Health Insurance Database 2000. Information of each patient was collected until December 2011. Cox proportional hazard regression analysis was used to obtain the adjusted hazard ratio for RRD. The RRD-free survival rate was calculated using Kaplan-Meier analysis.
  
  
  RESULTS
  Thirty-five patients with CSCR (1.24%) and 27 controls (0.16%) had RRD (P < 0.0001) during follow-up, resulting in a significantly higher risk of RRD in the patients with CSCR (incidence rate ratio = 7.83, 95% confidence interval = 4.74-12.93). After adjustment for potential confounders, the adjusted hazard ratio for developing RRD was increased 7.85 times in the cohort of total sample (adjusted hazard ratio = 7.85, 95% confidence interval = 4.75-12.97).
  
  
  CONCLUSIONS
  It was found that CSCR increased the risk of RRD even after adjustment for age, sex, and comorbidities including status after cataract operation, blunt trauma, myopia, diabetes mellitus, hypertension, and hyperlipidemia.
authors.affiliation: *Departments of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan; †Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan; ‡Department of Education, University of Taipei, Taipei, Taiwan; §Medical Research, Chi Mei Medical Center, Tainan, Taiwan; ¶Department of Hospital and Health-Care Administration, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan; **Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan; ††Department of Pediatrics, Chi Mei Medical Center, Liouying, Tainan, Taiwan; and ‡‡Graduate Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Yuh-Shin
authors.initials: YS
authors.lastname: Chang
authors.forename: Chun
authors.initials: C
authors.lastname: Chang
authors.forename: Shih-Feng
authors.initials: SF
authors.lastname: Weng
authors.forename: Jhi-Joung
authors.initials: JJ
authors.lastname: Wang
authors.forename: Ren-Long
authors.initials: RL
authors.lastname: Jan
mesh_terms: D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000150:complications / Q000453:epidemiology*; D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan