title: Use of the BioGRID Database for Analysis of Yeast Protein and Genetic Interactions.
abstract: The BioGRID database is an extensive repository of curated genetic and protein interactions for the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyces pombe, and the yeast Candida albicans SC5314, as well as for several other model organisms and humans. This protocol describes how to use the BioGRID website to query genetic or protein interactions for any gene of interest, how to visualize the associated interactions using an embedded interactive network viewer, and how to download data files for either selected interactions or the entire BioGRID interaction data set.
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Rose
authors.initials: R
authors.lastname: Oughtred
authors.affiliation: Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3C 3J7, Canada;
authors.forename: Andrew
authors.initials: A
authors.lastname: Chatr-aryamontri
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
authors.forename: Bobby-Joe
authors.initials: BJ
authors.lastname: Breitkreutz
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Christie S
authors.initials: CS
authors.lastname: Chang
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Rust
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Chandra L
authors.initials: CL
authors.lastname: Theesfeld
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Sven
authors.initials: S
authors.lastname: Heinicke
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
authors.forename: Ashton
authors.initials: A
authors.lastname: Breitkreutz
authors.affiliation: Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3C 3J7, Canada;
authors.forename: Daici
authors.initials: D
authors.lastname: Chen
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Jodi
authors.initials: J
authors.lastname: Hirschman
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
authors.forename: Nadine
authors.initials: N
authors.lastname: Kolas
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Michael S
authors.initials: MS
authors.lastname: Livstone
authors.affiliation: School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom.
authors.forename: Julie
authors.initials: J
authors.lastname: Nixon
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
authors.forename: Lara
authors.initials: L
authors.lastname: O'Donnell
authors.affiliation: School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Ramage
authors.affiliation: School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom.
authors.forename: Andrew
authors.initials: A
authors.lastname: Winter
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
authors.forename: Teresa
authors.initials: T
authors.lastname: Reguly
authors.affiliation: Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3C 3J7, Canada;
authors.forename: Adnane
authors.initials: A
authors.lastname: Sellam
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
authors.forename: Chris
authors.initials: C
authors.lastname: Stark
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada;
authors.forename: Lorrie
authors.initials: L
authors.lastname: Boucher
authors.affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544;
authors.forename: Kara
authors.initials: K
authors.lastname: Dolinski
authors.affiliation: Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3C 3J7, Canada; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada; School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom.
authors.forename: Mike
authors.initials: M
authors.lastname: Tyers
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D005656:Fungal Proteins / Q000235:genetics* / Q000378:metabolism*; D053263:Gene Regulatory Networks; D020407:Internet; D025941:Protein Interaction Mapping; D015003:Yeasts / Q000378:metabolism
chemical_list: D005656:Fungal Proteins