title: Effect of antipsoriatic therapy on oxidative stress index and sialic acid levels in patients with psoriasis.
abstract: OBJECTIVE
  Recent studies have implicated the association between oxidative stress and inflammation in pathogenesis of psoriasis and its associated comorbidities. Hence, we undertook to study inflammatory markers such as sialic acids and the oxidative stress index (OSI) in patients with psoriasis vulgaris.
  
  
  METHODS
  Sixty cases and 60 healthy controls were included in this cohort study. Disease severity was assessed by psoriasis area severity index scoring. Serum levels of oxidative stress (total oxidant status, total antioxidant status) and inflammation (highly sensitive C-reactive protein [hs-CRP], total sialic acid, protein bound sialic acid) markers were estimated in controls and cases at baseline and on follow-up. OSI was calculated as the ratio of total oxidant status to total antioxidant status.
  
  
  RESULTS
  Baseline serum levels of OSI, hs-CRP, and sialic acids were significantly higher in cases compared to controls. Baseline OSI and sialic acids demonstrated a significant correlation with disease severity. After 12 weeks of therapy, there was a significant decline in OSI and serum levels of hs-CRP and sialic acids.
  
  
  CONCLUSIONS
  Our results demonstrate that oxidative stress and inflammation are significantly associated with psoriasis, and treatment with methotrexate results in a significant decline of both the inflammatory and oxidative stress parameters.
authors.affiliation: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors.forename: Medha
authors.initials: M
authors.lastname: Rajappa
authors.affiliation: Department of Dermatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors.forename: Rathika
authors.initials: R
authors.lastname: Shanmugam
authors.affiliation: Department of Dermatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors.forename: Malathi
authors.initials: M
authors.lastname: Munisamy
authors.affiliation: Department of Dermatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors.forename: Laxmisha
authors.initials: L
authors.lastname: Chandrashekar
authors.affiliation: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors.forename: Kalai Selvi
authors.initials: KS
authors.lastname: Rajendiran
authors.affiliation: Department of Dermatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
authors.forename: Devinder Mohan
authors.initials: DM
authors.lastname: Thappa
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007194:India; D016014:Linear Models; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D015999:Multivariate Analysis; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D018384:Oxidative Stress / Q000187:drug effects* / Q000276:immunology; D011379:Prognosis; D011565:Psoriasis / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology; D012720:Severity of Illness Index; D012737:Sex Factors; D018709:Statistics, Nonparametric; D013638:Tars / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D013638:Tars; D002097:C-Reactive Protein; D019158:N-Acetylneuraminic Acid; D008727:Methotrexate