title: 'Dual hit' metabolic modulator LDCA selectively kills cancer cells by efficient competitive inhibition of LDH-A.
abstract: Herein, we synthesize and elucidate the potential of a novel 'dual hit' molecule, LDCA, to constitutively block lactate dehydrogenase isoform-A (LDH-A) to selectively subvert apoptosis and rigorously attenuate breast tumor progression in a mouse model, comprehensively delineating the therapeutic prospectus of LDCA in the field of cancer metabolics.
authors.affiliation: Division of Drug Development, Diagnostics and Biotechnology, CSIR- Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata-700032, West Bengal, India. samirkdutta@iicb.res.in.
authors.forename: Monisankar
authors.initials: M
authors.lastname: Ghosh
authors.affiliation: Division of Drug Development, Diagnostics and Biotechnology, CSIR- Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata-700032, West Bengal, India. samirkdutta@iicb.res.in.
authors.forename: Suchandrima
authors.initials: S
authors.lastname: Saha
authors.affiliation: Division of Drug Development, Diagnostics and Biotechnology, CSIR- Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata-700032, West Bengal, India. samirkdutta@iicb.res.in.
authors.forename: Samir Kumar
authors.initials: SK
authors.lastname: Dutta
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors*; D000080864:Lactate Dehydrogenase 5; D051379:Mice; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology*
chemical_list: D004791:Enzyme Inhibitors; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D000080864:Lactate Dehydrogenase 5