title: Enhanced efficacy of a topical antioxidants regimen in conjunction with a home-use non-ablative fractional diode laser in photodamaged facial skin.
abstract: BACKGROUND
  Photodamaged facial skin is characterized by fine lines and wrinkles, mottled pigmentation, and other changes.
  
  
  OBJECTIVE
  To evaluate and compare the efficacy and tolerance of a home-use laser device when used alone or in combination with an antioxidant facial treatment for moderate photodamage.
  
  
  METHODS
  This was a 49-subject, evaluator-blinded, split-face, randomized, single-center, 24-week, phase-2, study. In phase 1, all subjects were treated on one facial side with test products and a home-use laser device and the other side was treated with laser alone for 12 weeks, followed by a 2-week regression period during which they used only support materials. For phase 2, all subjects were divided into 2 independent treatment groups. For the next 10 weeks, subjects of first group treated the assigned facial side with test products and support materials and the other facial side with only support materials. Subjects in the second group treated their entire face with only support materials. Efficacy and tolerance were assessed by clinical grading, VISIA-CR imaging, and self-assessment questionnaires.
  
  
  RESULTS
  The combination of laser and test products improved all photodamage parameters evaluated.
  
  
  CONCLUSIONS
  The test products enhanced and prolonged clinical benefits obtained with the laser alone.
authors.affiliation: a Laser & Skin Surgery Center of New York , New York , NY , USA ;
authors.forename: Roy
authors.initials: R
authors.lastname: Geronemus
authors.affiliation: b L'Oreal Research & Innovation , Clark , NJ , USA ;
authors.forename: Ana
authors.initials: A
authors.lastname: Du
authors.affiliation: b L'Oreal Research & Innovation , Clark , NJ , USA ;
authors.forename: Margarita
authors.initials: M
authors.lastname: Yatskayer
authors.affiliation: b L'Oreal Research & Innovation , Clark , NJ , USA ;
authors.forename: Stephen
authors.initials: S
authors.lastname: Lynch
authors.affiliation: c SkinCeuticals Inc. , New York , NY , USA.
authors.forename: Yevgeniy
authors.initials: Y
authors.lastname: Krol
authors.affiliation: b L'Oreal Research & Innovation , Clark , NJ , USA ;
authors.forename: Christian
authors.initials: C
authors.lastname: Oresajo
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D003879:Dermatologic Agents / Q000008:administration & dosage; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000628:therapy*; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012060:Rejuvenation; D016037:Single-Blind Method; D015595:Skin Aging / Q000187:drug effects / Q000528:radiation effects; D012880:Skin Pigmentation
chemical_list: D000975:Antioxidants; D003879:Dermatologic Agents
keywords: Antioxidants; cosmeceuticals; home-use laser; photodamage