title: Chitosan/poly-γ-glutamic acid nanoparticles improve the solubility of lutein.
abstract: The aim of this study was to improve the solubility of lutein through the use of chitosan (CS)/poly-γ-glutamic acid (γ-PGA) nanoencapsulation. In terms of redispersibility, water-soluble chitosan (WsCS)/γ-PGA nanoparticles (NPs) were better than insoluble chitosan (InCS)/γ-PGA NPs. The lutein-loaded WsCS/γ-PGA NP has a spherical form with a size around 200nm and a narrow size distribution (PDI<0.1). Solubility measures showed that nanoencapsulation of lutein into WsCS/γ-PGA NPs resulted in a significant 12-fold higher solubility compared to that of non-nanoencapsulated lutein (p<0.05). The redispersibility index of the lutein-loaded NPs was 1.01, indicating that they were completely reconstituted into aqueous solution as same as original aqueous solution. These results suggest that WsCS/γ-PGA nanoencapsulation can be used to enhance the solubility of lutein and other poorly water-soluble compounds.
authors.affiliation: Department of Food and Nutrition, Hanyang University, 17 Haengdang-dong, Sungdong-gu, Seoul 133-791, Republic of Korea.
authors.forename: Da Young
authors.initials: DY
authors.lastname: Hong
authors.affiliation: Department of Food and Nutrition, Hanyang University, 17 Haengdang-dong, Sungdong-gu, Seoul 133-791, Republic of Korea.
authors.forename: Ji-Soo
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Food and Nutrition, Hanyang University, 17 Haengdang-dong, Sungdong-gu, Seoul 133-791, Republic of Korea. Electronic address: hyeonlee@hanyang.ac.kr.
authors.forename: Hyeon Gyu
authors.initials: HG
authors.lastname: Lee
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D004339:Drug Compounding; D014975:Lutein / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D012995:Solubility
chemical_list: C511775:poly(gamma-glutamic acid); D011099:Polyglutamic Acid; D048271:Chitosan; D014975:Lutein
keywords: Lutein; Nanoparticle; Solubility