title: Chronic and low charge injection wireless intraneural stimulation in vivo.
abstract: Functional stability and in-vivo reliability are significant factors determining the longevity of a neural interface. In this ongoing study, we test the performance of a wireless floating microelectrode array (WFMA) over a period of 143 days. The topography of the microelectrodes has allowed for selective stimulation of different fascicles of the rat sciatic nerve. We confirmed that motor evoked thresholds remain stable over time and that the nerve stimulation charges were within tissue safety limits. Importantly, motor evoked responses were elicited at threshold currents in fully awake animals without causing pain or discomfort. These data validate the use of the WFMA system for intraneural interfacing of peripheral nerves for neuroprosthetic and bioelectronics medical applications.
authors.forename: Mario
authors.initials: M
authors.lastname: Romero-Ortega
authors.forename: Aswini
authors.initials: A
authors.lastname: Kanneganti
authors.forename: Geetanjali
authors.initials: G
authors.lastname: Bendale
authors.forename: Jennifer
authors.initials: J
authors.lastname: Seifert
authors.forename: Samuel
authors.initials: S
authors.lastname: Bredeson
authors.forename: Philip
authors.initials: P
authors.lastname: Troyk
authors.forename: Felix
authors.initials: F
authors.lastname: Deku
authors.forename: Stuart
authors.initials: S
authors.lastname: Cogan
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D007267:Injections; D008839:Microelectrodes; D051381:Rats; D015203:Reproducibility of Results; D012584:Sciatic Nerve; D059015:Wireless Technology