title: Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine.
abstract: Pegaspargase is a chemotherapy drug used in the treatment of acute lymphoblastic leukemia (ALL). One of the adverse effects of pegaspargase is hepatotoxicity, which can rapidly lead to liver failure and death. We report a patient with ALL who developed pegaspargase-induced severe hepatotoxicity that was rescued by treatment with vitamin B complex and L-carnitine. Our patient had a quicker response than prior reported cases, suggesting this treatment might be a better regimen.
authors.affiliation: Department of Hematology/Oncology, Division of Internal Medicine, Baylor Scott & White Health, Temple, Texas.
authors.forename: Gary
authors.initials: G
authors.lastname: Lu
authors.affiliation: Department of Hematology/Oncology, Division of Internal Medicine, Baylor Scott & White Health, Temple, Texas.
authors.forename: Vinit
authors.initials: V
authors.lastname: Karur
authors.affiliation: Department of Hematology/Oncology, Division of Internal Medicine, Baylor Scott & White Health, Temple, Texas.
authors.forename: Jon D
authors.initials: JD
authors.lastname: Herrington
authors.affiliation: Department of Hematology/Oncology, Division of Internal Medicine, Baylor Scott & White Health, Temple, Texas.
authors.forename: Mary G
authors.initials: MG
authors.lastname: Walker