title: Synthesis, structures and urease inhibitory activity of cobalt(III) complexes with Schiff bases.
abstract: A series of new cobalt(III) complexes were prepared. They are [CoL(1)(py)3]·NO3 (1), [CoL(2)(bipy)(N3)]·CH3OH (2), [CoL(3)(HL(3))(N3)]·NO3 (3), and [CoL(4)(MeOH)(N3)] (4), where L(1), L(2), L(3) and L(4) are the deprotonated form of N'-(2-hydroxy-5-methoxybenzylidene)-3-methylbenzohydrazide, N'-(2-hydroxybenzylidene)-3-hydroxylbenzohydrazide, 2-[(2-dimethylaminoethylimino)methyl]-4-methylphenol, and N,N'-bis(5-methylsalicylidene)-o-phenylenediamine, respectively, py is pyridine, and bipy is 2,2'-bipyridine. The complexes were characterized by infrared and UV-Vis spectra, and single crystal X-ray diffraction. The Co atoms in the complexes are in octahedral coordination. Complexes 1 and 4 show effective urease inhibitory activities, with IC50 values of 4.27 and 0.35 μmol L(-1), respectively. Complex 2 has medium activity against urease, with IC50 value of 68.7 μmol L(-1). While complex 3 has no activity against urease. Molecular docking study of the complexes with Helicobacter pylori urease was performed.
authors.affiliation: Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, PR China.
authors.forename: Changling
authors.initials: C
authors.lastname: Jing
authors.affiliation: School of Life Sciences, Shandong University of Technology, Zibo 255049, PR China.
authors.forename: Cunfang
authors.initials: C
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Shandong University of Technology, Zibo 255049, PR China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yan
authors.affiliation: School of Life Sciences, Shandong University of Technology, Zibo 255049, PR China.
authors.forename: Kedong
authors.initials: K
authors.lastname: Zhao
authors.affiliation: School of Life Sciences, Shandong University of Technology, Zibo 255049, PR China.
authors.forename: Guihua
authors.initials: G
authors.lastname: Sheng
authors.affiliation: Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, PR China.
authors.forename: Dan
authors.initials: D
authors.lastname: Qu
authors.affiliation: Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Niu
authors.affiliation: School of Life Sciences, Shandong University of Technology, Zibo 255049, PR China.
authors.forename: Hailiang
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, PR China. Electronic address: youzhonglu@126.com.
authors.forename: Zhonglu
authors.initials: Z
authors.lastname: You
mesh_terms: D003035:Cobalt / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000201:enzymology; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012545:Schiff Bases / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014510:Urease / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D009942:Organometallic Compounds; D012545:Schiff Bases; D003035:Cobalt; D014510:Urease
keywords: Cobalt complex; Crystal structure; Molecular docking; Schiff base; Urease inhibition