title: BDNF Val66Met genotype and neuroticism predict life stress: A longitudinal study from childhood to adulthood.
abstract: The brain-derived neurotrophic factor gene (BDNF) Val66Met polymorphism and life stress have been associated with negative emotionality (e.g., neuroticism), but relevant evidence is far from unequivocal. Possible confounding factors include the type and timing of stressful events measured, such as childhood adversity vs. recent stressful events, and variable gene × environment interactions. The aim of this study was to longitudinally assess the BDNF Val66Met polymorphism and environment interaction effect on neuroticism in a population representative sample, depending upon the type of stress, gender and family relations. In the original older cohort of the Estonian Children Personality Behavior and Health Study (ECPBHS, n=593), neuroticism was measured at age 15 (parental assessment), 18 and 25 (self-assessments). Childhood stress was reported at age 15, quality of family relations was measured at age 18, and recent stressful life events at age 25. The BDNF Val66Met polymorphism interacted with recent stressful life events, but not with childhood adversities, to impact neuroticism. Interestingly, in female participants, neuroticism at age 18 predicted future stressful life events dependent upon genotype: individuals with Val/Val genotype and high neuroticism experienced higher, but Met-allele carriers with high neuroticism lower stress exposure at age 25. Similar tendencies were observed using parental assessments at age 15. The protective effect of Met-allele in the high stress exposure group could result from better early family environment. In conclusion, we herewith provide further evidence for a role of BDNF gene variance contributing to plasticity in response to environmental demands.
authors.affiliation: Division of Neuropsychopharmacology, Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Ravila 14A, 50411 Tartu, Estonia; National Institute for Health Development, Estonian Centre of Behavioural and Health Sciences, Tallinn, Estonia.
authors.forename: Kelli
authors.initials: K
authors.lastname: Lehto
authors.affiliation: Department of Sports Biology and Physiotherapy, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Tartu, Estonia.
authors.forename: Jarek
authors.initials: J
authors.lastname: Mäestu
authors.affiliation: Division of Neuropsychopharmacology, Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Ravila 14A, 50411 Tartu, Estonia.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Kiive
authors.affiliation: National Institute for Health Development, Estonian Centre of Behavioural and Health Sciences, Tallinn, Estonia.
authors.forename: Toomas
authors.initials: T
authors.lastname: Veidebaum
authors.affiliation: Division of Neuropsychopharmacology, Department of Psychology, Estonian Centre of Behavioural and Health Sciences, University of Tartu, Ravila 14A, 50411 Tartu, Estonia. Electronic address: jaanus.harro@ut.ee.
authors.forename: Jaanus
authors.initials: J
authors.lastname: Harro
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D001008:Anxiety Disorders / Q000235:genetics* / Q000523:psychology*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002648:Child; D005195:Family Relations; D005260:Female; D059647:Gene-Environment Interaction; D005838:Genotype; D006801:Humans; D008016:Life Change Events; D008137:Longitudinal Studies; D008297:Male; D008715:Methionine / Q000235:genetics; D000075384:Neuroticism; D010555:Personality Inventory; D011110:Polymorphism, Genetic / Q000235:genetics*; D013315:Stress, Psychological / Q000150:complications*; D014633:Valine / Q000235:genetics; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D008715:Methionine; D014633:Valine
keywords: BDNF genotype; Development; Gender; Gene–environment Interaction; Neuroticism; Stressful events