title: [Expressions of Snail, Slug and KAI1 proteins in cervical carcinoma and their clinicopathological significance].
abstract: OBJECTIVE
  To explore the expression of Snail and Slug in primary cervical squamous cell carcinoma (CSCC) and their relationship with KAI1 expression.
  
  
  METHODS
  The expressions of Snail, Slug, and KAI1 proteins were examined by immunohistochemistry in 154 specimens of CSCC tissues, 50 specimens of cervical intraepithelial neoplasm (CIN), and 40 specimens of normal cervical tissues.
  
  
  RESULTS
  The positivity rates of Snail, Slug, and KAI1 expression were 0%, 2.5%, and 95.0% in normal cervical tissues, 32.0%, 34.0% and 64.0% in CIN tissues, and 66.2%, 66.9%, and 43.5% in CSCC tissues, respectively, showing significant differences in the rates among the 3 groups (P<0.05). The expressions of Snail, Slug, and KAI1 were significantly correlated with the histological grades of the tumor, depth of invasion, lymph node metastasis, International Federation of Gynecology and Obstetrics (FIGO) stages, and postoperative survival time (P<0.05). The expressions of Snail and Slug were positively correlated (r=0.752, P<0.001), and both of them were negatively correlated with the expression of KAI1 (P<0.001). Kaplan-Meier analysis showed that patients positive for Snail and Slug had significantly lower survival rates than the negative patients (P<0.001), while a positive expression of KAI1 was associated with a higher survival rate of the patients. Cox regression analysis identified Snail, KAI1, and FIGO stage as independent factors that affected the outcomes of CSCC (P<0.05).
  
  
  CONCLUSIONS
  The expressions of Snail, Slug, and KAI1 are related to the tumor grade, FIGO stage, invasive depth, lymph node metastasis, and prognosis of CSCC, and their combined detection can help estimate the outcomes of the patients.
authors.affiliation: Department of Pathology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China. E-mail: gongxmeng@163.com.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Gong
authors.forename: Yisheng
authors.initials: Y
authors.lastname: Tao
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.forename: Lan
authors.initials: L
authors.lastname: Yu
authors.forename: Shiwu
authors.initials: S
authors.lastname: Wu
authors.forename: Wenqing
authors.initials: W
authors.lastname: Song
authors.forename: Danna
authors.initials: D
authors.lastname: Wang
authors.forename: Zenong
authors.initials: Z
authors.lastname: Cheng
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051861:Kangai-1 Protein / Q000378:metabolism*; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D000071250:Snail Family Transcription Factors; D015996:Survival Rate; D014157:Transcription Factors / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000378:metabolism / Q000473:pathology
chemical_list: D051861:Kangai-1 Protein; C000604407:SNAI1 protein, human; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors