title: Multiple viral introductions: molecular characterization of influenza B virus in Wenzhou, Zhejiang, China, from 2011 to 2014 based on hemagglutinin and neuraminidase genes.
abstract: Influenza B virus is a major causative agent of respiratory disease in humans. Our study of an outbreak of influenza B virus in Wenzhou from 2011 to 2014 revealed that 163 (5.58 %) of 2921 samples were influenza B positive. Sequencing of the hemagglutinin and neuraminidase genes showed substitutions at the amino acid level. Phylogenetic analysis revealed co-circulation of the B/Victoria and B/Yamagata lineages in the Wenzhou area from 2011 to 2014. Multiple viral introductions from both Chinese and international sources played important roles in endemic co-circulation and transmission in coastal southeastern China.
authors.affiliation: Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.affiliation: First People's Hospital of Huzhou, Huzhou Teachers College, Huzhou, Zhejiang, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wen
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou, 310051, Zhejiang, China. ysun@cdc.zj.cn.
authors.forename: Yi
authors.identifier: http://orcid.org/0000-0001-7549-8286
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou, 310051, Zhejiang, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Mao
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou, 310051, Zhejiang, China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou, 310051, Zhejiang, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou, 310051, Zhejiang, China.
authors.forename: Xinying
authors.initials: X
authors.lastname: Wang
authors.affiliation: Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang, China.
authors.forename: Baochang
authors.initials: B
authors.lastname: Sun
authors.affiliation: Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000595:Amino Acid Sequence; D002681:China / Q000453:epidemiology; D015967:Gene Expression Regulation, Viral / Q000502:physiology; D006388:Hemagglutinins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009981:Influenza B virus / Q000235:genetics*; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology*; D008969:Molecular Sequence Data; D009439:Neuraminidase / Q000235:genetics / Q000378:metabolism*; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D006388:Hemagglutinins; D012367:RNA, Viral; D014764:Viral Proteins; D009439:Neuraminidase
keywords: Influenza B virus; Molecular epidemiology; Phylogenetic; Victoria; Yamagata