title: Altered dendritic cell subset distribution in patients with Parkinson's disease: Impact of CMV serostatus.
abstract: Parkinson's disease (PD) is characterised by low-level systemic inflammation, which may be at least partly due to pathophysiological activation of immunity. Here, the frequencies of different types of circulating dendritic cells (DCs) with and without a pro-inflammatory phenotype were determined in PD patients and controls. A high proportion of older people is infected with cytomegalovirus (CMV), which acts as a chronic antigenic stressor that could also contribute to increased inflammation. Following this idea, we found higher frequencies of myeloid DCs with a pro-inflammatory CD16+ILT2(high) phenotype in CMV-positive PD patients than controls, suggesting the potential involvement of CMV in exacerbating PD.
authors.affiliation: Department of Internal Medicine II, Centre for Medical Research, University of Tübingen, Tübingen Aging and Tumour Immunology Group, Waldhörnlestr. 22, 72072 Tübingen, Germany. Electronic address: david.goldeck@uni-tuebingen.de.
authors.forename: David
authors.initials: D
authors.lastname: Goldeck
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Hoppe Seyler-Str. 3, 72076 Tübingen, Germany; German Center of Neurodegenerative Diseases, University of Tübingen, Germany.
authors.forename: Walter
authors.initials: W
authors.lastname: Maetzler
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Hoppe Seyler-Str. 3, 72076 Tübingen, Germany; German Center of Neurodegenerative Diseases, University of Tübingen, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Berg
authors.affiliation: Department of Internal Medicine II, Centre for Medical Research, University of Tübingen, Tübingen Aging and Tumour Immunology Group, Waldhörnlestr. 22, 72072 Tübingen, Germany.
authors.forename: Lilly
authors.initials: L
authors.lastname: Oettinger
authors.affiliation: Department of Internal Medicine II, Centre for Medical Research, University of Tübingen, Tübingen Aging and Tumour Immunology Group, Waldhörnlestr. 22, 72072 Tübingen, Germany; School of Science and Technology, Nottingham Trent University, Nottingham, UK.
authors.forename: Graham
authors.initials: G
authors.lastname: Pawelec
mesh_terms: D000328:Adult; D000368:Aged; D003587:Cytomegalovirus / Q000302:isolation & purification* / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism* / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000276:immunology / Q000821:virology*; D010865:Pilot Projects
keywords: Cytomegalovirus; Ig-like transcript 2; Myeloid dendritic cells; Plasmacytoid dendritic cells