title: [Study of 3D-pcASL in differentiation of acute cerebral infarction and acute encephalitis].
abstract: OBJECTIVE
  To investigate the value of three-dimentional pseudo-continuous arterial spin labeling (ASL) perfusion imaging in differentiating acute cerebral infarction from acute encephalitis.
  
  
  METHODS
  From September 2013 to September 2014, 42 patients with actue stroke onset and 20 healthy volunteers underwent conventional brain MRI DWI and 3D-ASL Perfusion Imaging in our hospital. Only 20 patients whose lesions located in the middle cerebral artery (MCA) territory were enrolled in this study. Of these cases, 12 cases were diagnosed with acute cerebral infarction, 8 were diagnosed with encephalitis. First, we analyzed the imaging features of the 20 patients and 20 volunteers. Then, CBF values of the lesions in the 20 patients and the gray matter of MCA territory in the 20 volunteers were measured on 3D-pcASL images. Third, the difference of mean CBF values between patients and volunteers were analyzed.
  
  
  RESULTS
  Out of 20 study group, 19 patients whose lesions presented high signal intensity on DWI images, 12 cases were acute cerebral infarction and 8 were encephalitis. All the lesions of 20 cases showed abnormal perfusion on 3D-pcASL images. 3D-pcASL has good consistency with DWI in diagnostic capabilities (χ² = 0.565, P = 0.01). On 3D-pcASL, 11 acute cerebral infarction patients presented perfusion defects or low perfusion, 1 acute cerebral infarction patients showed high perfusion, 8 encephalitis patients showed inhomogeneous perfusion. The mean value of CBF was (17 ± 6) ml · min⁻¹ · 100 g⁻¹ in 12 acute cerebral infarction patients, (136 ± 69) ml · min⁻¹ · 100 g⁻¹ in 8 encephalitis patients and (68 ± 12) ml · min⁻¹ · 100 g⁻¹ three in 20 healthy volunteers. The difference in mean value of CBF among the three groups was statistically significant (P < 0.01).
  
  
  CONCLUSIONS
  Acute cerebral infarction often shows low perfusion and acute encephalitis shows high perfusion on 3D-pcASL images, which has a higher application value in diagnosis and differentiation of acute cerebral infarction and encephalitis.
authors.affiliation: Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Chuanwan
authors.initials: C
authors.lastname: Mao
authors.affiliation: Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Yuchuan
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Xinjian
authors.initials: X
authors.lastname: Ye
authors.affiliation: Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Aiqin
authors.initials: A
authors.lastname: Wu
authors.affiliation: Department of Radiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China; Email: yanzhihan@sohu.com.
authors.forename: Zhihan
authors.initials: Z
authors.lastname: Yan
mesh_terms: D001921:Brain; D002545:Brain Ischemia; D002544:Cerebral Infarction; D004660:Encephalitis; D006801:Humans; D021621:Imaging, Three-Dimensional; D018810:Magnetic Resonance Angiography; D020768:Middle Cerebral Artery; D010477:Perfusion; D013113:Spin Labels; D020521:Stroke
chemical_list: D013113:Spin Labels