title: [Potentiation of activation of soluble guanylate cyclase by YC-1, NO-donors and increase of the synergistic effect of YC-1 on NO-dependent activation of the enzyme by 1,2,3-triazolyl-1,2,5-oxadiazole derivatives].
abstract: The influence of (1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole derivatives: 4-amino-3-(5-methyl-4- ethoxycarbonyl-(1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole (TF4CH3) and 4,4'-bis(5-methel-4-ethoxycarbonyl-1H- 1,2,3-triazol-1-yl)-3,3'-azo-1,2,5-oxadiazole (2TF4CH3) on stimulation of human platelet soluble guanylate cyclase by YC-1, NO-donors (sodium nitroprusside, SNP, and spermine NONO) and on a synergistic increase of NO-dependent enzyme activation in the presence of YC-1 has been investigated. Both compounds increased guanylate cyclase activation by YC-1, potentiated guanylate cyclase stimulation by NO-donors and increased the synergistic effect of YC-1 on NO-dependent activation of soluble guanylate cyclase. The similarity in the properties of the examined TF4CH3 and 2TF4CH3 with that of YC-1 and the possible mechanism underlying the revealed properties of compounds used are discussed.
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: I S
authors.initials: IS
authors.lastname: Severina
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Pyatakova
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Shchegolev
authors.affiliation: Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia.
authors.forename: V Yu
authors.initials: VY
authors.lastname: Rozhkov
authors.affiliation: Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Batog
authors.affiliation: Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Makhova
mesh_terms: D000328:Adult; D004789:Enzyme Activation; D006162:Guanylate Cyclase / Q000737:chemistry*; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000737:chemistry*; D010069:Oxadiazoles / Q000737:chemistry*; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry*; D000071756:Soluble Guanylyl Cyclase
chemical_list: D020030:Nitric Oxide Donors; D010069:Oxadiazoles; D018160:Receptors, Cytoplasmic and Nuclear; D009569:Nitric Oxide; D006162:Guanylate Cyclase; D000071756:Soluble Guanylyl Cyclase
keywords: (1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole derivatives; YC-1; nitric oxidt; soluble guanylate cyclase