title: Cardiac Arrest in a Heart Transplant Patient Receiving Dexmedetomidine During Cardiac Catheterization.
abstract: Dexmedetomidine is an α-2 agonist with a sedative and cardiopulmonary profile that makes it an attractive anesthetic in pediatric cardiac patients. Cardiac transplant patients may suffer from acute cellular rejection of the cardiac conduction system and, therefore, are at an increased risk of the electrophysiological effect of dexmedetomidine. We present such a patient who had a cardiac arrest while receiving dexmedetomidine during cardiac catheterization. Because acute cellular rejection of the cardiac conduction system is difficult to diagnose, dexmedetomidine should be used with caution in pediatric heart transplant patients.
authors.affiliation: Children's Hospital Colorado, Aurora, CO, USA University of Colorado, Denver, Aurora, CO, USA lawrence.schwartz@childrenscolorado.org.
authors.forename: Lawrence Israel
authors.initials: LI
authors.lastname: Schwartz
authors.affiliation: Children's Hospital Colorado, Aurora, CO, USA University of Colorado, Denver, Aurora, CO, USA.
authors.forename: Shelley D
authors.initials: SD
authors.lastname: Miyamoto
authors.affiliation: Children's Hospital Colorado, Aurora, CO, USA University of Colorado, Denver, Aurora, CO, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Stenquist
authors.affiliation: Children's Hospital Colorado, Aurora, CO, USA University of Colorado, Denver, Aurora, CO, USA.
authors.forename: Mark David
authors.initials: MD
authors.lastname: Twite
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000009:adverse effects*; D000328:Adult; D006328:Cardiac Catheterization; D020927:Dexmedetomidine / Q000009:adverse effects*; D005260:Female; D006323:Heart Arrest / Q000209:etiology*; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine
keywords: cardiac anesthesia; circulatory arrest; dexmedetomidine; electrophysiology; heat transplant