title: New Insights into the Pathogenesis of MDS and the rational therapeutic opportunities.
abstract: Myelodysplastic syndromes (MDS) include a heterogeneous group of acquired hematopoietic malignancies characterized by ineffective hematopoiesis, peripheral cytopenias, and a varying propensity for progression to acute myeloid leukemia. The clinical heterogeneity in MDS is a reflection of its molecular heterogeneity. Better understanding of aberrant epigenetics, dysregulation of immune responses, and del(5q) MDS has provided the rationale for well-established treatments in MDS. Further understanding of abnormal signal transduction and aberrant apoptosis pathways has led to development of new rational therapies that are in advanced phases of clinical translation. This review seeks to describe recent developments in our understanding of the pathogenesis of MDS and the potential therapeutic implications of these observations.
authors.affiliation: a Division of Hematology Oncology , Mount Sinai Beth Israel , New York , NY , USA.
authors.forename: Abdallah
authors.initials: A
authors.lastname: Abou Zahr
authors.affiliation: b Department of Internal Medicine , Mount Sinai Beth Israel , New York , NY , USA.
authors.forename: Carolina
authors.initials: C
authors.lastname: Bernabe Ramirez
authors.affiliation: c Division of Hematology Oncology , Lancaster General Hospital , Lancaster , PA , USA.
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Wozney
authors.affiliation: d Division of Hematology, Department of Medicine , Yale University , New Haven , CT , USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Prebet
authors.affiliation: d Division of Hematology, Department of Medicine , Yale University , New Haven , CT , USA.
authors.forename: Amer M
authors.initials: AM
authors.lastname: Zeidan
mesh_terms: D047389:Casein Kinase I / Q000235:genetics; D019175:DNA Methylation; D057890:Epigenomics; D018380:Hematopoietic Stem Cell Transplantation; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D009154:Mutation; D009190:Myelodysplastic Syndromes / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D011379:Prognosis
chemical_list: D006657:Histones; D007521:Isocitrate Dehydrogenase; D047389:Casein Kinase I
keywords: DNMTI; Del5q; Epigenetics; Myelodysplastic syndrome; Pathogenesis; immune dysregulation