title: Recurrent giant mandibular ameloblastoma in young adults.
abstract: The purpose of the study was to define the most appropriate management of the giant mandibular ameloblastoma (GMA) in young adults.
  
  
  
  A retrospective study was performed on patients with GMA <30 years old. The data collected included initial treatment, tumor margins, reconstruction, and follow-up. Patients evaluated speech, chewing, swallowing, and facial appearance after definitive treatment.
  
  
  
  Thirteen patients were identified with recurrent solid/multicystic disease requiring further treatment. Definitive treatment involved segmental mandibulectomy and reconstruction with free fibular flap in all patients. Seven patients had immediate reconstruction (group A) and 6 had secondary (group B). Mandibular resection was planned at least 2 cm beyond the radiological limit, free margins were achieved in all patients, and all flaps were transplanted successfully. In group A, functional score was 13.7 ± 0.45 and facial appearance score was 4.5 ± 0.49, whereas in group B were 11.16 ± 0.37 and 3.3 ± 0.5, respectively (both p < .05).
  
  
  
  Aggressive resection of the GMA and immediate reconstruction is strongly advised. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1947-E1954, 2016.
authors.affiliation: Department of Plastic Surgery - Microsurgery and Burn Center " J. Ioannovich", General State Hospital of Athens "G. Gennimatas", Athens, Greece.
authors.forename: Andreas
authors.initials: A
authors.lastname: Gravvanis
authors.affiliation: Department of Oral and Maxillofacial Surgery, General State Hospital of Athens "G. Gennimatas", Athens, Greece.
authors.forename: Harry D
authors.initials: HD
authors.lastname: Koumoullis
authors.affiliation: Department of Oral and Maxillofacial Surgery, General State Hospital of Athens "G. Gennimatas", Athens, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Anterriotis
authors.affiliation: Department of Plastic Surgery - Microsurgery and Burn Center " J. Ioannovich", General State Hospital of Athens "G. Gennimatas", Athens, Greece.
authors.forename: Dimosthenis
authors.initials: D
authors.lastname: Tsoutsos
authors.affiliation: Department of Oral and Maxillofacial Surgery, General State Hospital of Athens "G. Gennimatas", Athens, Greece.
authors.forename: Nick
authors.initials: N
authors.lastname: Katsikeris
mesh_terms: D000328:Adult; D000564:Ameloblastoma / Q000503:physiopathology* / Q000601:surgery*; D016025:Bone Transplantation; D005260:Female; D005360:Fibula / Q000637:transplantation; D006801:Humans; D008297:Male; D008334:Mandible / Q000473:pathology; D008339:Mandibular Neoplasms / Q000503:physiopathology* / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000503:physiopathology* / Q000601:surgery*; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D055815:Young Adult
keywords: free fibular flap; giant mandibular ameloblastoma; immediate reconstruction; mandibular ameloblastoma; recurrence