title: CANCER STEM CELLS IN OSTEOSARCOMA.
abstract: Osteosarcoma is the most common type of bone cancer and the second leading cause of cancer-related deaths in pediatric patients. Despite conventional treatments such as surgery and chemotherapy, long-term survival rates for patients diagnosed with osteosarcoma have not improved over the last 30 years, likely due to drug-resistant metastasis and disease recurrence. An emerging concept in cancer research is that within a heterogeneous tumor there is a small subset of cells called "cancer stem cells" that are responsible for drug resistance, tumor recurrence and metastasis. This brief review summarizes our current knowledge about cancer stem cells in osteosarcoma, including their potential as a new target for osteosarcoma treatment.
authors.affiliation: Department of Orthopaedic Surgery, Case Western Reserve University.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Bashur
authors.affiliation: Department of Orthopaedic Surgery, Case Western Reserve University.
authors.forename: Guang
authors.initials: G
authors.lastname: Zhou