title: Co-Administration of Saireito Enabled the Withdrawal of Corticosteroids in an Elderly Woman with Autoimmune Hepatitis.
abstract: An 82-year-old woman with autoimmune hepatitis had been treated with 5 mg prednisolone (PSL) orally to maintain normal transaminase levels. The subsequent transaminase levels were elevated and remained unchanged despite increasing the dose of PSL to 20 mg and introducing ursodeoxycholic acid (UDCA) at a dose of 900 mg. This combined treatment with UDCA was, however, ineffective. Treatment with Saireito at a dose of 9.0 g in conjunction with PSL was then initiated, which led to the subsequent normalization of her transaminase levels. Oral administration of PSL was discontinued eight weeks after the co-administration of Saireito. The patient had a significant response to this treatment.
authors.affiliation: 2nd Department of Internal Medicine, Osaka Medical College, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Fukunishi
authors.forename: Shinya
authors.initials: S
authors.lastname: Nishida
authors.forename: Ken
authors.initials: K
authors.lastname: Nakamura
authors.forename: Keisuke
authors.initials: K
authors.lastname: Yokohama
authors.forename: Hideko
authors.initials: H
authors.lastname: Ohama
authors.forename: Akira
authors.initials: A
authors.lastname: Asai
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tsuda
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Higuchi
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D019693:Hepatitis, Autoimmune / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D011239:Prednisolone / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D004365:Drugs, Chinese Herbal; C080903:sairei-to; D011239:Prednisolone; D000410:Alanine Transaminase