title: Behavioral effects in mice of postnatal exposure to low-doses of 137-cesium and bisphenol A.
abstract: Bisphenol A (BPA) is the most important plasticizer used in many household products such as polycarbonate plastics or epoxy resins. Public and scientific concerns exist regarding the possibility that the neonatal exposure to BPA may contribute to neurobehavioral disorders. On the other hand, there is little information on the effects of low doses of ionizing radiation during critical phases of postnatal brain development, as well as the combination of radiation and environmental chemicals. In this study, C57BL/6J mice were exposed to low doses of internal radiation ((137)Cs), and/or BPA on postnatal day 10 (PND10). At the age of two months, animals were submitted to several tests to assess anxiety, activity, learning, and memory. Results showed that exposure to (137)Cs, alone or in combination with BPA, increased the anxiety-like of the animals without changing the activity levels. Animals exposed to (137)Cs showed impaired learning, and spatial memory, an impairment that was not observed in the groups co-exposed to BPA.
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain; CRAMC (Research Center for Behavior Assessment), Department of Psychology, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Heredia
authors.affiliation: Physiology Unit, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain; Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Bellés
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: LLovet
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: Jose L
authors.initials: JL
authors.lastname: Domingo
authors.affiliation: Physiology Unit, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain; Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Spain. Electronic address: mvictoria.linares@urv.cat.
authors.forename: Victoria
authors.initials: V
authors.lastname: Linares
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001007:Anxiety / Q000139:chemically induced / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects* / Q000528:radiation effects*; D001559:Benzhydryl Compounds / Q000633:toxicity*; D001921:Brain / Q000187:drug effects* / Q000254:growth & development / Q000528:radiation effects*; D002588:Cesium Radioisotopes / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D018782:Maze Learning / Q000187:drug effects / Q000528:radiation effects; D008569:Memory Disorders / Q000139:chemically induced / Q000523:psychology; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects / Q000528:radiation effects; D010636:Phenols / Q000633:toxicity*; D010968:Plasticizers / Q000633:toxicity*; D065852:Spatial Memory / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D002588:Cesium Radioisotopes; D010636:Phenols; D010968:Plasticizers; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: 137-Cesium; Behavior; Bisphenol A; Ionizing radiation; Mice; Postnatal