title: Systemic administration of omeprazole interferes with bone healing and implant osseointegration: an in vivo study on rat tibiae.
abstract: BACKGROUND
  Proton pump inhibitors, over-the-counter drugs taken by millions of patients, diminish bone accrual. Accordingly, we hypothesized that these drugs could impair bone healing and implant osseointegration. This study investigated the effect of post-operative systemic administration of omeprazole on bone healing and implant osseointegration in rat tibiae.
  
  
  METHODS
  In 24 Sprague-Dawley rats, a titanium implant was placed in the left tibia, and a bone defect was created in the right tibia. During the 2 weeks following surgery, 12 rats were treated with omeprazole (5 mg/kg, daily) and the other 12 with saline. Then, after euthanasia, the volume (mm(3) ) of the cortical defect and the percentages of newly formed bone in the defect, were assessed using microcomputed tomography; peri-implant bone volume/tissue volume and bone-implant contact percentage were assessed by histomorphometry.
  
  
  RESULTS
  Omeprazole-treated rats presented larger cortical defects (2.75 ± 0.59 mm(3) , p = 0.003 versus 2.11 ± 0.36 mm(3) ; p = 0.002) and a lower percentage of newly formed bone in the defects (28.62 ± 13.12; 45.89 ± 9.73; p = 0.003) than controls. Omeprazole-treated rats presented lower peri-implant bone volume/tissue volume (14.3 ± 7.3% versus 30.8 ± 11.0%; p < 0.001) and bone-implant contact (23.3 ± 10.8% versus 41.8 ± 13.3%; p < 0.001) than controls.
  
  
  CONCLUSIONS
  Systemically administered omeprazole impairs bone healing and implant osseointegration.
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, QC, Canada.|College of Dentistry, University of Dammam, Dammam, Saudi Arabia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Al Subaie
authors.affiliation: Faculty of Dentistry, University of Montreal, Montreal, QC, Canada.
authors.forename: Elham
authors.initials: E
authors.lastname: Emami
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, QC, Canada.
authors.forename: Iskandar
authors.initials: I
authors.lastname: Tamimi
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, QC, Canada.
authors.forename: Marco
authors.initials: M
authors.lastname: Laurenti
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, QC, Canada.
authors.forename: Hazem
authors.initials: H
authors.lastname: Eimar
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, QC, Canada.
authors.forename: Mohamed-Nur
authors.initials: MN
authors.lastname: Abdallah
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, QC, Canada.
authors.forename: Faleh
authors.initials: F
authors.lastname: Tamimi
mesh_terms: D000818:Animals; D015921:Dental Implants; D005260:Female; D009853:Omeprazole / Q000627:therapeutic use*; D016348:Osseointegration; D051381:Rats; D017207:Rats, Sprague-Dawley; D013977:Tibia; D014025:Titanium; D055114:X-Ray Microtomography
chemical_list: D015921:Dental Implants; D014025:Titanium; D009853:Omeprazole
keywords: bone healing; implant; omeprazole; osseointegration; proton pump inhibitors; titanium