title: [Impact of preoperative dual antiplatelet therapy on perioperative bleeding in patients undergoing off-pump coronary artery bypass grafting].
abstract: OBJECTIVE
  To evaluate the impact of preoperative dual antiplatelet therapy of aspirin and clopidogrel on perioperative blood loss and blood transfusion requirements.
  
  
  METHODS
  A total of 60 patients underwent off-pump coronary artery bypass grafting (OPCABG) performed by the same surgeons. And they were assigned to receive dual antiplatelet therapy of aspirin and clopidogrel (group AC, n = 30) and discontinue antiplatelet therapy more than 5 days before surgery (group control, n = 30).
  
  
  RESULTS
  No significant inter-group differences existed in basic clinical characteristics (all P > 0.05). Itraoperative blood loss volume was similar for two groups (637 ± 257 vs 635 ± 196 ml, P = 0.978). No significant inter-group difference existed in 24 h chest drainage volume (522 ± 160 vs 524 ± 204 ml, P = 0.961) or total volume of chest drainage (1044 ± 337 vs 1118 ± 198 ml, P = 0.306).
  
  
  CONCLUSIONS
  Preoperative dual antiplatelet therapy of aspirin and clopidogrel does not increase the total volume of postoperative chest drainage.
authors.affiliation: Department of Cardiac Surgery, Affiliated Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Jinwei
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Cardiac Surgery, Affiliated Anzhen Hospital, Capital Medical University, Beijing 100029, China; Email: huangfj999@sina.com.
authors.forename: Fangjiong
authors.initials: F
authors.lastname: Huang
authors.affiliation: Department of Cardiac Surgery, Affiliated Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Jinfei
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Cardiac Surgery, Affiliated Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Cardiac Surgery, Affiliated Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cardiac Surgery, Affiliated Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Cardiac Surgery, Affiliated Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Yixi
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Department of Cardiac Surgery, Affiliated Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Enjun
authors.initials: E
authors.lastname: Zhu
mesh_terms: D001241:Aspirin; D001803:Blood Transfusion; D000077144:Clopidogrel; D047549:Coronary Artery Bypass, Off-Pump; D006470:Hemorrhage; D006801:Humans; D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine / Q000031:analogs & derivatives
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin