title: Safety and Efficacy of Transcatheter Closure of Patent Ductus Arteriosus With Severe Mitral Regurgitation in Adults.
abstract: BACKGROUND
  Transcatheter closure is the usual treatment for patent ductus arteriosus (PDA), but its safety and efficacy have not been reported in adult PDA patients with severe mitral regurgitation.
  
  
  METHODS
  A retrospective study on 27 consecutive patients diagnosed with PDA and severe mitral regurgitation and treated using transcatheter closure between September 2010 and September 2012 at the Department of Cardiology of Changhai Hospital in Changhai, China. Left ventricular (LV) diastolic volume and function, pulmonary artery pressure, and instantaneous reverse-flow volume were examined by echocardiography before PDA closure, immediately after closure, and 1 year after closure.
  
  
  RESULTS
  After the procedure, the LV diastolic volume (P<.05) and instantaneous reverse-flow volume (P<.001) were significantly decreased. There was no effect on the ejection fraction (P>.05). Pulmonary arterial systolic pressure was unchanged 1 year after closure (from 46.41 ± 19.92 mm Hg to 45.43 ± 13.64 mm Hg; P=.58). All procedures were uneventful and only mild complications occurred (hemolysis in 2 cases, subcutaneous hematoma in 4 cases, and fever in 2 cases).
  
  
  CONCLUSIONS
  Transcatheter closure can decrease the LV volume and instantaneous reverse-flow volume in adult PDA patients with severe mitral regurgitation. This procedure is effective and has a good safety profile.
authors.forename: Zhongkai
authors.initials: Z
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.forename: Yongwen
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China. zxxmedsci@163.com.
authors.forename: Xianxian
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000328:Adult; D006328:Cardiac Catheterization / Q000379:methods*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D002681:China; D004374:Ductus Arteriosus, Patent / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000209:etiology; D010043:Outcome and Process Assessment, Health Care; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology; D012189:Retrospective Studies; D055989:Septal Occluder Device; D012720:Severity of Illness Index