title: The role of nitric oxide in regulation of leukocyte migration into the heart tissue in vitro.
abstract: Characteristics of leukocyte migration have been studied during the incubation of the right and left ventricles of rat heart explants in autologous blood plasma. Within the first 60 min, the leukocyte amount in the medium increases. Moreover, it is associated with cell release from the heart tissue. During further incubation, the cell release decreases; after 3 h of incubation, the cells begin to migrate back into the heart tissue. However, neutrophil migration does not change. Sodium nitrite, being a donor of nitric oxide significantly, reduces the leukocyte migration from the heart explants into the incubation medium, especially from left ventricle explants.
authors.affiliation: St. Petersburg State University, St. Petersburg, 199034, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Petenkova
authors.affiliation: St. Petersburg State University, St. Petersburg, 199034, Russia.
authors.forename: R I
authors.initials: RI
authors.lastname: Kovalenko
authors.affiliation: St. Petersburg State University, St. Petersburg, 199034, Russia. nastia_85@list.ru.
authors.forename: A D
authors.initials: AD
authors.lastname: Nozdrachev
mesh_terms: D000818:Animals; D054441:Cell Migration Assays, Leukocyte; D002465:Cell Movement; D006352:Heart Ventricles / Q000166:cytology / Q000378:metabolism*; D007962:Leukocytes / Q000166:cytology / Q000378:metabolism*; D009504:Neutrophils / Q000166:cytology / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D009924:Organ Culture Techniques; D051381:Rats
chemical_list: D009569:Nitric Oxide