title: Substance P and Acute Pain in Patients Undergoing Orthopedic Surgery.
abstract: OBJECTIVE
  There is a limited information about the role of Substance P (SP) in acute pain nociception following surgical stimulation in patients with a chronic inflammatory state not to mention the link between this neuropeptide level changes and intensity of pain. The goal of the research was to find the correlation between SP level changes and acute pain intensity in patients with rheumatoid arthritis undergoing elective orthopedic surgery.
  
  
  METHODS
  Patients with rheumatoid arthritis (RA) were enrolled in the study. The correlation between acute pain intensity and concentration of SP in serum as well as in drainage fluid from postoperative wound was assessed in patients with RA who underwent Total Knee Replacement (TKA) under spinal anesthesia.
  
  
  RESULTS
  In patients with RA a correlation between intensity of acute pain and serum SP was found postoperatively, whereas there was no correlation between intensity of acute pain and concentration of SP in drainage fluid.
  
  
  CONCLUSIONS
  1. The correlation between acute pain intensity and SP serum concentration was found postoperatively in patients with RA. 2. The correlation between acute pain intensity and SP concentration in drainage fluid was not found postoperatively in patients with RA.
authors.affiliation: Department of Anaesthesiology, Medical Centre for Postgraduate Education Clinical Hospital Adam Gruca, CMKP Otwock, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Lisowska
authors.affiliation: Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Siewruk
authors.affiliation: Faculty of Production Engineering, Warsaw University of Life Sciences, Warsaw, Poland.
authors.forename: Aleksander
authors.initials: A
authors.lastname: Lisowski
mesh_terms: D059787:Acute Pain / Q000097:blood* / Q000601:surgery; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000601:surgery; D019645:Arthroplasty, Replacement, Knee; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013373:Substance P / Q000097:blood*
chemical_list: D013373:Substance P