title: 1 Protein Methyltransferases: Their Distribution Among the Five Structural Classes of AdoMet-Dependent Methyltransferases.
abstract: S-adenosyl-l-methionine (AdoMet) dependent methyltransferases (MTases) are involved in biosynthesis, signal transduction, protein repair, chromatin regulation, and gene silencing. Five different structural folds (designated I through V) have been described that bind AdoMet and catalyze methyltransfer to diverse substrates, although the great majority of known MTases have the Class I fold. Even within a particular MTase class the amino-acid sequence similarity can be as low as 10%. Thus, the structural and catalytic requirements for methyltransfer from AdoMet appear to be remarkably flexible. MTases that act on protein substrates have been found to date among three of the five structural classes (I, the classical fold; III, the corrin MTase fold; and V, the SET fold). "There are many paths to the top of the mountain, but the view is always the same."-Chinese proverb The Columbia World of Quotations, New York, Columbia University Press, 1996.
authors.affiliation: Department of Biochemistry University of Utah 15 North Medical DriveEast Salt Lake City, UT 84112, USA.
authors.forename: Heidi L
authors.initials: HL
authors.lastname: Schubert
authors.affiliation: Department of Medical Microbiology and Immunology and Program in Bioinformatics and Proteomics/Genomics Medical University of Ohio 3000 Arlington Avenue Toledo, OH 43614, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Blumenthal
authors.affiliation: Department of Biochemistry Emory University School of Medicine 1510 Clifton Road Northeast Atlanta, GA 30322, USA.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Cheng