title: Adipose triglyceride lipase (Atgl) mediates the antibiotic jinggangmycin-stimulated reproduction in the brown planthopper, Nilaparvata lugens Stål.
abstract: The antibiotic jinggangmycin (JGM) is an agrochemical product widely used in China for controlling rice sheath blight, Rhizoctonia solani. Unexpectedly, it stimulates reproduction in the brown planthopper (BPH), Nilaparvata lugens (Stål). However, the underlying molecular mechanisms of the stimulation are unclear. The present investigation demonstrates that adipose triglyceride lipase (Atgl) is one of the enzymes involved in the JGM-stimulated reproduction in BPH. Silence of Atgl in JGM-treated (JGM + dsAtgl) females eliminated JGM-stimulated fecundity of BPH females. In addition, Atgl knockdown significantly reduced the protein and glycerin contents in the ovaries and fat bodies of JGM + dsAtgl females required for reproduction. We conclude that Atgl is one of the key enzymes responsible for JGM-stimulated reproduction in BPH.
authors.affiliation: School of Plant Protection, Yangzhou University, Yangzhou 220059, P.R. China.
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Jiang
authors.affiliation: School of Plant Protection, Yangzhou University, Yangzhou 220059, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: School of Plant Protection, Yangzhou University, Yangzhou 220059, P.R. China.
authors.forename: Zong-Yu
authors.initials: ZY
authors.lastname: Liu
authors.affiliation: School of Plant Protection, Yangzhou University, Yangzhou 220059, P.R. China.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: You
authors.affiliation: School of Plant Protection, Yangzhou University, Yangzhou 220059, P.R. China.
authors.forename: You
authors.initials: Y
authors.lastname: Wu
authors.affiliation: School of Plant Protection, Yangzhou University, Yangzhou 220059, P.R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
authors.affiliation: School of Plant Protection, Yangzhou University, Yangzhou 220059, P.R. China.
authors.forename: Lin-Quan
authors.initials: LQ
authors.lastname: Ge
authors.affiliation: Division of Plant Sciences, University of Missouri, Columbia, MO 65211, USA.
authors.forename: Qi-Sheng
authors.initials: QS
authors.lastname: Song
authors.affiliation: School of Plant Protection, Yangzhou University, Yangzhou 220059, P.R. China.
authors.forename: Jin-Cai
authors.initials: JC
authors.lastname: Wu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D005216:Fat Body / Q000201:enzymology; D005260:Female; D005990:Glycerol / Q000378:metabolism; D006430:Hemiptera / Q000201:enzymology*; D007294:Inositol / Q000031:analogs & derivatives* / Q000494:pharmacology; D019476:Insect Proteins / Q000502:physiology*; D008049:Lipase / Q000502:physiology*; D008297:Male; D010053:Ovary / Q000201:enzymology; D012098:Reproduction / Q000187:drug effects; D059467:Transcriptome / Q000187:drug effects; D015854:Up-Regulation
chemical_list: D000900:Anti-Bacterial Agents; D019476:Insect Proteins; C030790:validamycin A; D007294:Inositol; D008049:Lipase; D005990:Glycerol