title: EFFECT OF INTRAOPERATIVE MITOMYCIN-C APPLICATION IN OUTCOME OF EXTERNAL DACRYOCYSTORHINOSTOMY.
abstract: BACKGROUND
  Patients develop postoperative fibrosis at the site of operation after dacryocystorhinostomy (DCR) which results in impairment of the osteum patency. This quasi-experimental study was undertaken to determine the role of intraoperative Mitomycin C (MMC) application in maintaining postoperative patency of the osteum.
  
  
  METHODS
  The present study was conducted at the Eye department of Ayub Medical College, Abbottabad on patients in whom routine DCR was indicated. Subjects were divided into mitomycin C (Test) and non mitomycin C (Control) groups. In test group, Mitomycin C was applied to the anastomosed flaps and osteotomy site for 30 minutes. Postoperative patients were followed for up to 6 months and outcome of patency was documented.
  
  
  RESULTS
  A.total of 73 patients were included, divided into test (30) and control (43) groups. An overall success rate of 86.3% was obtained for patent ostia; this was based on 96.67% success in test group compared to 79.1% in the control group (p=0.031).
  
  
  CONCLUSIONS
  Intraoperative application of Mitomycin-C significantly improves the success rate in external dacryocystorhinostomy.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Jawad
authors.forename: Zulfiqar
authors.initials: Z
authors.lastname: Ali
authors.forename: Sumbal
authors.initials: S
authors.lastname: Tariq
authors.forename: Iftikhar
authors.initials: I
authors.lastname: Qayum
authors.forename: Hamad
authors.initials: H
authors.lastname: Aftab
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D003607:Dacryocystitis / Q000517:prevention & control*; D003608:Dacryocystorhinostomy / Q000379:methods*; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D007767:Lacrimal Duct Obstruction / Q000628:therapy*; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin