title: Contactin 1 as a potential biomarker promotes cell proliferation and invasion in thyroid cancer.
abstract: Contactin 1 (CNTN1) as a member of the immunoglobulin superfamily plays important role in the development of nervous system. Recent studies find that elevated CNTN1 can promote the metastasis of cancer. However, the expression and function of CNTN1 in thyroid cancer are still unknown. Here, we firstly find CNTN1 is a new gene which can be regulated by RET/PTC3 (Ret proto-oncogene and Ret-activating protein ELE1) rearrangement gene and the protein level of CNTN1 is increasing in thyroid cancer. Besides this change is positively associated with the TNM stage and tumor size. Moreover, we confirm that knockdown of CNTN1 significantly inhibits the tumor proliferation, invasiveness and represses the expression of cyclin D1 (CCND1). In conclusion, CNTN1 will be a potential diagnosis biomarker and therapy target for thyroid cancer.
authors.affiliation: Department of Ultrasonography, Zhejiang Cancer Hospital Hangzhou 310022, China.
authors.forename: Kaiyuan
authors.initials: K
authors.lastname: Shi
authors.affiliation: Department of Ultrasonography, Zhejiang Cancer Hospital Hangzhou 310022, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Xu
authors.affiliation: Department of Ultrasonography, Zhejiang Cancer Hospital Hangzhou 310022, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Ultrasonography, Zhejiang Cancer Hospital Hangzhou 310022, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Ultrasonography, Zhejiang Cancer Hospital Hangzhou 310022, China.
authors.forename: Weiyun
authors.initials: W
authors.lastname: Pan
authors.affiliation: Oncological Surgery of Head and Neck, Zhejiang Cancer Hospital Hangzhou 310022, China.
authors.forename: Chuanming
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Department of Radiology, Zhejiang Cancer Hospital Hangzhou 310022, China.
authors.forename: Linyin
authors.initials: L
authors.lastname: Fan
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D015153:Blotting, Western; D049109:Cell Proliferation / Q000502:physiology; D058967:Contactin 1 / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D055785:Gene Knockdown Techniques; D015321:Gene Rearrangement; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness / Q000235:genetics* / Q000473:pathology; D000090063:Proto-Oncogene Mas; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics; D034741:RNA, Small Interfering; D060888:Real-Time Polymerase Chain Reaction; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology*; D014162:Transfection
chemical_list: D014408:Biomarkers, Tumor; C548669:CNTN1 protein, human; D058967:Contactin 1; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D034741:RNA, Small Interfering; D051096:Proto-Oncogene Proteins c-ret
keywords: RET; Thyroid cancer; biomarker; contactin 1; metastasis; rearrangement