title: Expression of Early Growth Response Gene-2 and Regulated Cytokines Correlates with Recovery from Guillain-Barré Syndrome.
abstract: Guillain-Barré syndrome (GBS) is an immune-mediated peripheral neuropathy. The goal of this research was the identification of biomarkers associated with recovery from GBS. In this study, we compared the transcriptome of PBMCs from a GBS patient and her healthy twin to discover possible correlates of disease progression and recovery. The study was then extended using GBS and spinal cord injury unrelated patients with similar medications and healthy individuals. The early growth response gene-2 (EGR2) was upregulated in GBS patients during disease recovery. The results provided evidence for the implication of EGR2 in GBS and suggested a role for EGR2 in the regulation of IL-17, IL-22, IL-28A, and TNF-β cytokines in GBS patients. These results identified biomarkers associated with GBS recovery and suggested that EGR2 overexpression has a pivotal role in the downregulation of cytokines implicated in the pathophysiology of this acute neuropathy.
authors.affiliation: Hospital Nacional de Parapléjicos, Servicio de Salud de Castilla La Mancha, 45071 Toledo, Spain;
authors.forename: Ernesto
authors.identifier: http://orcid.org/0000-0002-2704-9782
authors.initials: E
authors.lastname: Doncel-Pérez
authors.affiliation: SaBio, Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, 13005 Ciudad Real, Spain;
authors.forename: Lourdes
authors.initials: L
authors.lastname: Mateos-Hernández
authors.affiliation: Oh no sequences! Research Group, Era7 Bioinformatics, 18001 Granada, Spain;
authors.forename: Eduardo
authors.identifier: http://orcid.org/0000-0002-7878-0786
authors.initials: E
authors.lastname: Pareja
authors.affiliation: Hospital Nacional de Parapléjicos, Servicio de Salud de Castilla La Mancha, 45071 Toledo, Spain;
authors.forename: Ángel
authors.initials: Á
authors.lastname: García-Forcada
authors.affiliation: SaBio, Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, 13005 Ciudad Real, Spain;
authors.forename: Margarita
authors.initials: M
authors.lastname: Villar
authors.affiliation: Oh no sequences! Research Group, Era7 Bioinformatics, 18001 Granada, Spain;
authors.forename: Raquel
authors.identifier: http://orcid.org/0000-0001-7032-8720
authors.initials: R
authors.lastname: Tobes
authors.affiliation: Hospital Nacional de Parapléjicos, Servicio de Salud de Castilla La Mancha, 45071 Toledo, Spain;
authors.forename: Francisco
authors.initials: F
authors.lastname: Romero Ganuza
authors.affiliation: Hospital Nacional de Parapléjicos, Servicio de Salud de Castilla La Mancha, 45071 Toledo, Spain;
authors.forename: Virginia
authors.identifier: http://orcid.org/0000-0002-5606-2767
authors.initials: V
authors.lastname: Vila Del Sol
authors.affiliation: Fundación Parque Científico de Madrid, 28049 Madrid, Spain; and.
authors.forename: Ricardo
authors.identifier: http://orcid.org/0000-0002-6331-9786
authors.initials: R
authors.lastname: Ramos
authors.affiliation: SaBio, Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, 13005 Ciudad Real, Spain;
authors.forename: Isabel G
authors.identifier: http://orcid.org/0000-0001-5936-4018
authors.initials: IG
authors.lastname: Fernández de Mera
authors.affiliation: SaBio, Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, 13005 Ciudad Real, Spain; Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078 jose_delafuente@yahoo.com.
authors.forename: José
authors.initials: J
authors.lastname: de la Fuente
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis*; D016207:Cytokines / Q000096:biosynthesis; D051767:Early Growth Response Protein 2 / Q000096:biosynthesis* / Q000276:immunology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D020127:Recovery of Function; D059467:Transcriptome; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; C497326:EGR2 protein, human; D051767:Early Growth Response Protein 2