title: Dynamic thiol/disulphide homeostasis in patients with newly diagnosed primary hypertension.
abstract: We aimed to investigate the thiol/disulphide homeostasis in patients with newly diagnosed primary hypertension with a novel and automated method. Blood thiol/disulphide homeostasis, which consists of native thiol/disulphide exchanges, was investigated in 45 patients with primary hypertension and 45 healthy controls. The levels of native thiol, total thiol, and native thiol/total thiol ratio were lower while the disulphide level and disulphide/native thiol and disulphide/total thiol ratios were higher in patients with primary hypertension when compared with those in the control group. Positive correlation was detected between 24-hour systolic and diastolic blood pressure levels and disulphide/native thiol ratio. With reference to the stepwise multiple linear regression model; increase in disulphide/native thiol ratio and log(24-hour urine microalbumin) and decrease in native thiol/total thiol ratio are independent predictors of 24-hour systolic and diastolic blood pressure. This study demonstrated that thiol/disulphide homeostasis was shifted toward disulphide formation in patients with primary hypertension.
authors.affiliation: Internal Medicine Department, Ankara Numune Training and Research Hospital, Ankara, Turkey. Electronic address: dr.ihsanates@hotmail.com.
authors.forename: Ihsan
authors.initials: I
authors.lastname: Ates
authors.affiliation: Nephrology Department, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Nihal
authors.initials: N
authors.lastname: Ozkayar
authors.affiliation: Internal Medicine Department, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Bayram
authors.initials: B
authors.lastname: Inan
authors.affiliation: Biochemistry Department, Ankara Numune Training and Research Hospital, Ankara, Turkey; Department of Biochemistry, Yildirim Beyazit University Medical Faculty, Ankara, Turkey.
authors.forename: Fatma Meric
authors.initials: FM
authors.lastname: Yilmaz
authors.affiliation: Biochemistry Department, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Topcuoglu
authors.affiliation: Department of Biochemistry, Yildirim Beyazit University Medical Faculty, Ankara, Turkey.
authors.forename: Salim
authors.initials: S
authors.lastname: Neselioglu
authors.affiliation: Department of Biochemistry, Yildirim Beyazit University Medical Faculty, Ankara, Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
authors.affiliation: Nephrology Department, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Dede
authors.affiliation: Internal Medicine Department, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Nisbet
authors.initials: N
authors.lastname: Yilmaz
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis* / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002623:Chemistry Techniques, Analytical / Q000379:methods; D004220:Disulfides / Q000097:blood / Q000378:metabolism*; D000075222:Essential Hypertension; D005260:Female; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D013438:Sulfhydryl Compounds / Q000097:blood / Q000378:metabolism*; D014421:Turkey
chemical_list: D000975:Antioxidants; D004220:Disulfides; D013438:Sulfhydryl Compounds
keywords: Blood pressure; oxidative stress; oxidized thiol; sulfur bonds