title: Production of interleukins 4 and 10 in children with hepatic involvement in the course of Toxocara spp. infection.
abstract: Toxocara spp. infestations present with a wide spectrum of symptoms, from general inflammation of internal organs with eosinophilic granuloma formulation through ocular or brain involvement. There is also an asymptomatic form. The known factors that influence the clinical form of the disease are the intensity of the infestation, the localization of the larvae, the age of the patient, the efficiency of the immune system and the history of reinfection. The aim of our study was to evaluate the production of interleukins 4 (IL-4) and 10 (IL-10) in children in the course of Toxocara spp. infections with hepatic involvement. The analysis of peripheral leucocytes, eosinophils, immunoglobulin E, and IL-4 and IL-10 concentrations presented significantly higher values in children with radiologically confirmed liver granuloma than in uncomplicated hepatomegaly. Based on statistical analysis, we confirmed the IL-4/IL-10 ratio variation in the analysed groups: patients with liver lesions showed a ratio of <1, while children without granulomas had a ratio of >2. The relevant analysis confirmed a positive statistical correlation in both seropositive groups for IgE and IL-4, and only in the granuloma group for IgE and IL-10.
authors.affiliation: Department of Infectious Diseases and Child Neurology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Mazur-Melewska
authors.affiliation: Department of Infectious Diseases and Child Neurology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Figlerowicz
authors.affiliation: Department of Infectious Diseases and Child Neurology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Cwalińska
authors.affiliation: Department of Paediatric Endocrinology and Rheumatology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Mikoś
authors.affiliation: Pediatric Radiology Department Chair of Radiology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Jończyk-Potoczna
authors.affiliation: Department of Paediatric Cardiology and Nephrology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Lewandowska-Stachowiak
authors.affiliation: Department of Infectious Diseases and Child Neurology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Służewski
mesh_terms: D000818:Animals; D002648:Child; D004803:Eosinophilic Granuloma / Q000276:immunology / Q000469:parasitology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007249:Inflammation / Q000276:immunology* / Q000469:parasitology; D016753:Interleukin-10 / Q000276:immunology*; D015847:Interleukin-4 / Q000276:immunology*; D007958:Leukocyte Count; D008099:Liver / Q000473:pathology; D008297:Male; D014119:Toxocara / Q000502:physiology*; D014120:Toxocariasis / Q000276:immunology* / Q000469:parasitology / Q000473:pathology
chemical_list: C508609:IL10 protein, human; C508598:IL4 protein, human; D016753:Interleukin-10; D015847:Interleukin-4; D007073:Immunoglobulin E
keywords: Toxocara spp.; children; granuloma; interleukin 10; interleukin 4