title: The effects of temperature changes on retinal ganglion cell responses to electrical stimulation.
abstract: Little is known about how the retina's response to electrical stimulation is modified by temperatures. In vitro experiments are often used to inform in vivo studies, hence it is important to understand what changes occur at physiological temperature. To investigate this, we recorded from eight RGCs in vitro at three temperatures; room temperature (24°C), 30°C and 34°C. Results show that response latencies and thresholds are reduced, bursting spike rates in response to stimulation increases, and the spiking becomes more consistently locked to the stimulus at higher temperatures.
authors.forename: Matias I
authors.initials: MI
authors.lastname: Maturana
authors.forename: Nicholas V
authors.initials: NV
authors.lastname: Apollo
authors.forename: David J
authors.initials: DJ
authors.lastname: Garrett
authors.forename: Tatiana
authors.initials: T
authors.lastname: Kameneva
authors.forename: Hamish
authors.initials: H
authors.lastname: Meffin
authors.forename: Michael R
authors.initials: MR
authors.lastname: Ibbotson
authors.forename: Shaun L
authors.initials: SL
authors.lastname: Cloherty
authors.forename: David B
authors.initials: DB
authors.lastname: Grayden
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000528:radiation effects*; D004558:Electric Stimulation; D051381:Rats; D020318:Rats, Long-Evans; D011930:Reaction Time / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000502:physiology* / Q000528:radiation effects*