title: [Analysis of Clinical Features and Prognosis in 31 Patients with Primary Myelofibrosis].
abstract: OBJECTIVE
  To investigate the clinical and laboratorial features of primary myelofibrosis (PMF) patients treated in our hospital, to analyze the risk factors influancing survival, and to compare several prognostic scoring systems.
  
  
  METHODS
  parameters about clinical and laboratorial features were taken from medical documents at diagnosis, univariate analysis was conducted by Kaplan-Meier method, the survival data were compared with Log-rank test, and a COX model was used for multivariate analyses.
  
  
  RESULTS
  In our center the anemia and JAK2V617F mutation were more common, while the abnormal karyotype was less common, the constitutional symptoms, splenomegaly, Hb level < 100 g/L and LDH are adverse factors for survival in univariate analysis. Constitutional symptoms and Plt count < 100 × 10(9)/L are adverse factors of survival according to multivariate analysis.
  
  
  CONCLUSIONS
  The anemia is more frequent in Chinese patients. Constitutional symptoms and Plt count < 100 × 10(9)/L are independent risk factors for survival. LILLI, modified IPSS, modified DIPSS are suitable to our data.
authors.affiliation: Department of Hematology, Zhongda Hospital, Southeast University Medical School, Nanjing 210009, Jiangsu Province, China.
authors.forename: Hai-Ju
authors.initials: HJ
authors.lastname: He
authors.affiliation: Department of Hematology, Zhongda Hospital, Southeast University Medical School, Nanjing 210009, Jiangsu Province, China. E-mail: cba8888@hotmail.com.
authors.forename: Bao-An
authors.initials: BA
authors.lastname: Chen
mesh_terms: D059786:Abnormal Karyotype; D044466:Asian People; D006801:Humans; D053614:Janus Kinase 2; D009154:Mutation; D055728:Primary Myelofibrosis; D011379:Prognosis; D012307:Risk Factors
chemical_list: C507924:JAK2 protein, human; D053614:Janus Kinase 2