title: Bilateral Spontaneous Hyphema, Vitreous Hemorrhage, and Choroidal Detachment With Concurrent Dabigatran Etexilate Therapy.
abstract: A 79-year-old woman was referred for rapid onset of painless bilateral vision loss. Anterior segment exams revealed bilateral spontaneous hyphema and fibrin accumulation. Observation of the posterior chamber by B-scan ultrasound showed vitreous hemorrhage and choroidal detachment bilaterally. No evidence of additional intraocular inflammation was present. Laboratory work-up for hematologic abnormalities was unremarkable. These hemorrhagic events were suspected to be a complication from taking the novel anticoagulant, dabigatran etexilate (Pradaxa; Boehringer, Ingelheim, Germany). She initially underwent non-surgical therapy, which included immediate cessation of dabigatran, and administration of topical and systemic steroids. The lack of response to medical therapy in the left eye led to surgical treatment of vitreous and persistent subcapsular hemorrhage via pars planar vitrectomy with capsulectomy.
authors.forename: Kevin
authors.initials: K
authors.lastname: Wang
authors.forename: Justis P
authors.initials: JP
authors.lastname: Ehlers
mesh_terms: D000368:Aged; D000991:Antithrombins / Q000009:adverse effects*; D001281:Atrial Fibrillation / Q000188:drug therapy; D015862:Choroid Diseases / Q000139:chemically induced* / Q000175:diagnosis; D000069604:Dabigatran / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006988:Hyphema / Q000139:chemically induced* / Q000175:diagnosis; D014792:Visual Acuity; D014823:Vitreous Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000991:Antithrombins; D000069604:Dabigatran