title: [Nodular regenerative hyperplasia associated with common variable immunodeficiency and other comorbidities].
abstract: OBJECTIVE
  Currently, there are not many data on the evolution of nodular regenerative hyperplasia (NRH) associated or not with underlying diseases and in particular that associated with common variable inmunodeficiency (CVID). Twenty cases of NRH are presented, and the differences between the cases associated with CVID and those related to other diseases are analysed.
  
  
  METHODS
  Retrospective and descriptive study over a period of 14 years.
  
  
  RESULTS
  Twelve out of the 20 patients were men; the median age was 51 years. CVID was the main illness associated with NRH. In patients with CVID and NRH, gastrointestinal haemorrhage was more common, all the patients had high gamma glutamyl transferase and alkaline phosphatase and none had altered albumin and bilirubin levels compared to the patients without CVID. On follow-up, 50% of patients with CVID (2/4) had died compared to 33.3% (5/15) without CVID.
  
  
  CONCLUSIONS
  NRH in patients with CVID seems to have more biochemical data of anicteric cholestasis and portal hypertension and could be associated with lower survival.
authors.affiliation: Servicio de Medicina Interna, Hospital General Universitario de Alicante, Alicante, España. Electronic address: leonr86@hotmail.com.
authors.forename: Rafael
authors.initials: R
authors.lastname: León
authors.affiliation: Servicio de Medicina Interna, Hospital General Universitario de Alicante, Alicante, España.
authors.forename: Rosario
authors.initials: R
authors.lastname: Sánchez-Martínez
authors.affiliation: Servicio de Medicina Digestiva, Hospital General Universitario de Alicante, Alicante, España; Departamento de Medicina Clínica, Universidad Miguel Hernández, Elche, Alicante, España.
authors.forename: José M
authors.initials: JM
authors.lastname: Palazón
authors.affiliation: Servicio de Anatomía Patológica, Hospital General Universitario de Alicante, Alicante, España.
authors.forename: Artemio
authors.initials: A
authors.lastname: Payá
authors.affiliation: Servicio de Medicina Interna, Hospital General Universitario de Alicante, Alicante, España; Departamento de Medicina Clínica, Universidad Miguel Hernández, Elche, Alicante, España.
authors.forename: José M
authors.initials: JM
authors.lastname: Ramos
authors.affiliation: Servicio de Medicina Interna, Hospital General Universitario de Alicante, Alicante, España.
authors.forename: Héctor
authors.initials: H
authors.lastname: Pinargote
mesh_terms: D000328:Adult; D000368:Aged; D017074:Common Variable Immunodeficiency / Q000150:complications*; D015897:Comorbidity; D004932:Esophageal and Gastric Varices / Q000209:etiology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D006965:Hyperplasia; D006975:Hypertension, Portal / Q000209:etiology*; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D053208:Kaplan-Meier Estimate; D008099:Liver / Q000473:pathology*; D008115:Liver Regeneration; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
keywords: Common variable immunodeficiency; Hiperplasia nodular regenerativa; Hipertensión portal; Inmunodeficiencia común variable; Nodular regenerative hyperplasia; Portal hypertension