title: Minocycline as A Substitute for Doxycycline in Targeted Scenarios: A Systematic Review.
abstract: Doxycycline, a commonly prescribed tetracycline, remains on intermittent shortage. We systematically reviewed the literature to assess minocycline as an alternative to doxycycline in select conditions, given doxycycline's continued shortage. We identified 19 studies, 10 of which were published before 2000. Thirteen of the studies were prospective, but only 1 of these studies was randomized. Based on the available data, we found minocycline to be a reasonable substitute for doxycycline in the following scenarios: skin and soft-tissue infections and outpatient treatment of community-acquired pneumonia in young, otherwise healthy patients or in patients with macrolide-resistant Mycoplasma pneumoniae, as well as Lyme disease prophylaxis and select rickettsial disease should doxycycline be unavailable.
authors.affiliation: Department of Pharmacotherapeutics and Clinical Research , University of South Florida College of Pharmacy ; Departments of Family Medicine.
authors.forename: Nicholas W
authors.initials: NW
authors.lastname: Carris
authors.affiliation: Department of Pharmacy , North Florida/South Georgia Veterans Health System , Gainesville.
authors.forename: Joe
authors.initials: J
authors.lastname: Pardo
authors.affiliation: Internal Medicine , University of South Florida, Morsani College of Medicine , Tampa.
authors.forename: Jose
authors.initials: J
authors.lastname: Montero
authors.affiliation: Department of Pharmacotherapeutics and Clinical Research , University of South Florida College of Pharmacy ; Internal Medicine , University of South Florida, Morsani College of Medicine , Tampa.
authors.forename: Kristy M
authors.initials: KM
authors.lastname: Shaeer
keywords: alternatives; doxycycline; minocycline; shortage; substitution