title: Role of atrium in automaticity of the sinus node.
abstract: As the electrical source of hearts, sino-atrial node cells (SANCs) play significant roles in rhythmic firings. Due to the complex structure and function of SANCs, electrical interactions of SAN and its surrounding atrium has not yet been fully understood. The aim of the present study is to investigate effects of coupling conductance between SAN and atrial cells as well as the ectopic beats in atrium on automaticity of the SAN by computer simulation methods. On the basis of a dynamic mathematical single cell model considering the heterogeneity of central and peripheral SANCs, a two-dimensional inhomogeneous tissue slice including SAN and atrium was developed. The operator splitting method was used to integrate the tissue model. The results demonstrated that the coupling conductance between SAN and atrium had effects on the direction of spontaneous action potential conduction in SAN. Weak coupling resulted in a shift of the earliest pacemaker site from central to peripheral SANCs. Additionally, the ectopic beat-induced excitation in atrium was found to be able to enter into and overdrive suppress the automaticity of SAN. Even if the ectopic beat was delivered after the spontaneous firing had started in central SANCs, the spontaneous conduction toward the periphery could also be suppressed by the retrograde activation from the entering atrial depolarization wave. These findings suggested a direct link between sinus node dysfunction and atrial arrhythmias, and therefore were helpful in explaining the role of atrium in sinus node dysfunction.
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: R J
authors.initials: RJ
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Huang
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001146:Arrhythmia, Sinus / Q000503:physiopathology; D016275:Atrial Function / Q000502:physiology*; D053840:Brugada Syndrome / Q000503:physiopathology; D000075224:Cardiac Conduction System Disease; D003198:Computer Simulation; D006325:Heart Atria / Q000166:cytology; D006801:Humans; D008955:Models, Cardiovascular; D011817:Rabbits; D012804:Sick Sinus Syndrome / Q000503:physiopathology; D012849:Sinoatrial Node / Q000166:cytology / Q000502:physiology*