title: Fabrication of Magnetic Upconversion Nanohybrid for Luminescent Resonance Energy Transfer-Based Detection of Glutathione.
abstract: This study introduces the facile fabrication of a bimodal nanohybrid for the luminescent ON/OFF detection of glutathione. The proposed nanosensor consists of magnetic (Fe3O4) and upconversion nanoparticles (UCP) co-encapsulated in a silica matrix, and decorated with gold nanoparticle (AuNP) as a luminescent quencher. The detection mechanism is based on the Luminescent Resonance Energy Transfer (LRET) between the donor (UCP) and the acceptor (AuNP) with the help of a disulfide bond as a bridging element. In the presence of glutathione, the disulfide bridges between AuNPs and Fe3O4/UCP@SiO2 was cleaved and the amount of glutathione could be traced by the restored luminescence (ON state) of the nanohybrids after magnetic separation.
authors.forename: Phuong-Diem
authors.initials: PD
authors.lastname: Nguyen
authors.forename: Vu Thanh
authors.initials: VT
authors.lastname: Cong
authors.forename: Sang Jun
authors.initials: SJ
authors.lastname: Son
authors.forename: Junhong
authors.initials: J
authors.lastname: Min
mesh_terms: D006046:Gold / Q000737:chemistry*; D008163:Luminescent Measurements / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D058185:Magnetite Nanoparticles; D006046:Gold; D012822:Silicon Dioxide