title: Higher BNP levels within physiological range correlate with beneficial nonfasting lipid profiles in the elderly: a cross-sectional study.
abstract: BACKGROUND
  Emerging studies indicate that B-type natriuretic peptide (BNP), a well-known biomarker for heart failure, also plays pivotal roles in metabolic control. Circulating BNP levels progressively increase as ages grow older. However, the association between BNP levels and lipid metabolism in the elderly remains unknown.
  
  
  METHODS
  A total of 680 eligible volunteers (male/female: 334/346) aged between 60 and 80 years old without overt heart failure (BNP <100 pg/ml) were enrolled. Random nonfasting venous samples were obtained for biochemical analysis. The subjects were stratified based on BNP quartiles: BNP Q1 (range: 2.2-9.0 pg/ml), Q2 (9.1-20.4 pg/ml), Q3 (20.5-44.4 pg/ml) and Q4 (44.6-99.7 pg/ml). Difference of metabolic parameters was compared among the subjects grouped by BNP quartiles. Univariate correlation and multiple linear regression were performed to analyze the association between BNP levels and metabolic parameters. The odds ratios (OR) and 95 % confidence intervals (CI) for dyslipidemia in subjects within BNP Q1-3 relative to subjects within BNP Q4 were calculated.
  
  
  RESULTS
  Circulating BNP levels positively correlated with age, while negatively correlated with body mass index (BMI), eGFR and non-HDL. Subjects with lower BNP quartiles had significantly elevated prevalence of dyslipidemia, including hypertriglyceridemia, hyper-LDL-emia and hypercholesterolemia. The OR of hypertriglyceridemia and hypercholesterolemia for subjects within BNP Q1-2 significantly increased relative to BNP Q4.
  
  
  CONCLUSIONS
  The elderly people with higher BNP levels have significantly reduced risks for nonfasting dyslipidemia. Verification of the cause-effect relationship between BNP and dyslipidemia may bring therapeutic implications.
authors.affiliation: Department of Community Medicine, Kanazawa Medical University Himi Municipal Hospital, Himi, Toyama, 935-8531, Japan. wthe@tjh.tjmu.edu.cn.|Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. wthe@tjh.tjmu.edu.cn.
authors.forename: Wen-Tao
authors.initials: WT
authors.lastname: He
authors.affiliation: Department of Community Medicine, Kanazawa Medical University Himi Municipal Hospital, Himi, Toyama, 935-8531, Japan. mori@kanazawa-med.ac.jp.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Mori
authors.affiliation: Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. jzxnn1@163.com.
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Yu
authors.affiliation: Department of Community Medicine, Kanazawa Medical University Himi Municipal Hospital, Himi, Toyama, 935-8531, Japan. kandat@kanazawa-med.ac.jp.
authors.forename: Tsugiyasu
authors.initials: T
authors.lastname: Kanda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood; D005215:Fasting / Q000097:blood*; D005260:Female; D006801:Humans; D016014:Linear Models; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012307:Risk Factors
chemical_list: D008055:Lipids; D020097:Natriuretic Peptide, Brain