title: The Intestinal Mucus Layer Comes of Age.
abstract: The mucus layer is critical in limiting contact between host and the complex bacterial consortia that colonize the intestine. A recent paper in Cell Host and Microbe provides comprehensive insight into the dynamics of mucus layer maturation upon bacterial colonization of germ-free (GF) mice that have implications for studies on host-microbe interaction involving colonization of GF mice.
authors.affiliation: Molecular Microbiology and Immunology Department, Brown University, Providence, RI, USA. Electronic address: shipra_vaishnava@brown.edu.
authors.forename: Shipra
authors.initials: S
authors.lastname: Vaishnava
mesh_terms: D000818:Animals; D005856:Germ-Free Life; D054884:Host-Pathogen Interactions; D006801:Humans; D007239:Infections / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D064307:Microbiota; D055262:Mucin-2 / Q000235:genetics / Q000378:metabolism; D009093:Mucus / Q000276:immunology* / Q000382:microbiology; D000073718:Pancreatitis-Associated Proteins; D011506:Proteins / Q000378:metabolism
chemical_list: C524626:Muc2 protein, mouse; D055262:Mucin-2; D000073718:Pancreatitis-Associated Proteins; D011506:Proteins; C490255:Reg3g protein, mouse