title: The investigation of glucose metabolism and insulin secretion in subjects of chronic hepatitis B with cirrhosis.
abstract: OBJECTIVE
  To investigate the situations of abnormal glucose metabolism and dysfunction of pancreatic islet beta cells in subjects of chronic hepatitis B (CHB) with cirrhosis.
  
  
  METHODS
  106 hepatitis B virus (HBV) positive subjects with liver cirrhosis as well as with different grade of Child-Pugh and 37 healthy subjects were included in this study. The oral glucose tolerance test (OGTT), C-peptide and insulin release test were detected. Plasma glucose and insulin levels were analyzed periodically for 2 h after oral glucose loading.
  
  
  RESULTS
  There was no significant difference in the level of fasting plasma glucose and C-peptide between cirrhosis group and control group (P>0.05). The levels of OGTT 2 h glucose, insulin and C peptide were significantly higher in cirrhosis group than control group (P<0.01). Peak plasma glucose levels were obtained at 60 min in normal group and cirrhosis group. The peak insulin and C-peptide response occurred at 60 min in normal group, whereas it was delayed to 120 min in cirrhosis group. There was a significant difference between two groups in the pattern of plasma glucose levels at corresponding time points (P<0.05). The OGTT 2 h glucose and insulin levels were positively correlated with Child-Pugh Score (r1 = 0.389, r2 = 0.508, P<0.01).
  
  
  CONCLUSIONS
  These findings implied that there was a certain degree of insulin resistance and abnormal glucose metabolism in the patients with liver cirrhosis.
authors.affiliation: Department of Infectious Diseases, The Affiliated Jiangyin Hospital of Southeast University Medical College Jiangyin 214400, Jiangsu, China.
authors.forename: Chun-Hui
authors.initials: CH
authors.lastname: Guo
authors.affiliation: Department of Infectious Diseases, The Affiliated Jiangyin Hospital of Southeast University Medical College Jiangyin 214400, Jiangsu, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Sun
authors.affiliation: Department of Infectious Diseases, The Affiliated Jiangyin Hospital of Southeast University Medical College Jiangyin 214400, Jiangsu, China.
authors.forename: Xi-Ding
authors.initials: XD
authors.lastname: Weng
authors.affiliation: Department of Infectious Diseases, The Affiliated Jiangyin Hospital of Southeast University Medical College Jiangyin 214400, Jiangsu, China.
authors.forename: Jian-Chun
authors.initials: JC
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, The Affiliated Jiangyin Hospital of Southeast University Medical College Jiangyin 214400, Jiangsu, China.
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Chen
authors.affiliation: Department of Infectious Diseases, The Affiliated Jiangyin Hospital of Southeast University Medical College Jiangyin 214400, Jiangsu, China.
authors.forename: Guo-Jiong
authors.initials: GJ
authors.lastname: Deng
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology; D000078790:Insulin Secretion; D008103:Liver Cirrhosis / Q000378:metabolism* / Q000821:virology; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D005947:Glucose
keywords: Glucose metabolism; hepatitis virus; insulin secretion; liver cirrhosis; oral glucose tolerance test