title: FRZB up-regulated in hepatocellular carcinoma bone metastasis.
abstract: The clinical relevance of frizzled-related protein (FRZB) in hepatocellular carcinoma (HCC) bone metastasis remains uncertain. The aim of this study was to assess the clinical relationship of FRZB in patients with HCC bone metastasis after surgical resection. FRZB expression was evaluated by immunohistochemistry in formalin-fixed paraffin embedded (FFPE) HCC and paired bone metastasis tissues from 13 patients that underwent surgical resection. The clinical characteristics of 13 HCC patients with synchronous or metachronous bone metastasis received surgery were retrospectively reviewed. We found that FRZB was positive in 9 HCC tissues (69.2%) and in 11 paired bone metastatic tissues (84.6%) among these 13 paired samples. The expression of FRZB in the bone metastases was noticeably higher than that in the paired HCC tissues. The expression of FRZB was up-regulated in 10 (76.9%) paired bone metastases tissues. FRZB expression was up-regulated in HCC bone metastasis tissue, which suggested that FRZB might play a key role in the HCC bone metastasis.
authors.affiliation: Department of Cancer Chemotherapy and Radiotherapy, Yinzhou Hospital Affiliated to Medical School of Ningbo University Ningbo 315040, Zhejiang Province, P. R. China.
authors.forename: Jia
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Cancer Chemotherapy and Radiotherapy, Yinzhou Hospital Affiliated to Medical School of Ningbo University Ningbo 315040, Zhejiang Province, P. R. China.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Hu
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou 310003, Zhejiang, P. R. China.
authors.forename: Xiangjin
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou 310003, Zhejiang, P. R. China.
authors.forename: Xuanwei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Gastrointestinal Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University Shaoxing 312000, Zhejiang Province, P. R. China.
authors.forename: Ketao
authors.initials: K
authors.lastname: Jin
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D001859:Bone Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000556:secondary; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism / Q000556:secondary; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006023:Glycoproteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015854:Up-Regulation; D000099274:Frizzled-Related Proteins
chemical_list: D014408:Biomarkers, Tumor; D006023:Glycoproteins; D047908:Intracellular Signaling Peptides and Proteins; D000099274:Frizzled-Related Proteins
keywords: Hepatocellular carcinoma; bone metastasis; frizzled-related protein (FRZB)