title: A multi-criteria evaluation method for assessing the defibrillation outcome of different electrode placements in swine.
abstract: Compared with clinical and experimental approaches, numerical modeling of defibrillation offers a great opportunity to optimize the defibrillation strategy in a more individualized way. Through numerical simulation of the shock-induce electric field distribution, the outcome of a certain defibrillation shock could be predicted according to several different metrics. In this paper, we propose a novel evaluation method, in which four defibrillation criteria are assigned with separate weighting factors to quantitatively assess the efficiency of a certain defibrillation shock. Three anatomically realistic finite element models of swine were constructed for the evaluation study of 8 electrode pairs in different placements. In addition, corresponding animal experiments were performed to determine the defibrillation threshold of 8 electrode placements. Both computational and experimental results suggest that the clinical recommended anterior-lateral position is the most efficient electrode displacement for transthoracic defibrillation in swine. In conclusion, the good agreement between stimulations and experiments indicates that the present multi-criteria evaluation method would be potentially useful for optimizations of cardiac defibrillation outcome.
authors.lastname: Dakun Lai
authors.lastname: Pengye Li
authors.lastname: Qi Xu
mesh_terms: D032761:Animal Experimentation; D000818:Animals; D004554:Electric Countershock; D004560:Electricity; D004566:Electrodes; D006321:Heart; D013552:Swine; D014693:Ventricular Fibrillation