title: Schizophrenia Spectrum Disorders in a Danish 22q11.2 Deletion Syndrome Cohort Compared to the Total Danish Population--A Nationwide Register Study.
abstract: OBJECTIVE
  Cross-sectional studies have shown associations between 22q11.2 deletion syndrome and schizophrenia. However, large-scale prospective studies have been lacking. We, therefore, conducted the first large-scale population based study on the risk of being diagnosed with schizophrenia in persons identified with 22q11.2 deletion syndrome.
  
  
  METHODS
  Danish nationwide registers were linked to establish a cohort consisting of all Danish citizens born during 1955-2004 and the cohort was followed from January 1, 1994 until December 31, 2013. Data were analyzed using survival analyses and adjusted for calendar year, age, sex, and parental mental health history.
  
  
  RESULTS
  A total of 156 individuals with 22q11.2 deletion syndrome were identified, out of which 6 individuals were diagnosed with schizophrenia spectrum disorders following identification with 22q11 deletion syndrome. Identified carriers of 22q11.2 deletion had an 8.13(95% CI: 3.65-18.09) fold increased risk of schizophrenia spectrum disorder.
  
  
  CONCLUSIONS
  Carriers of a 22q11.2 deletion who had been clinically identified had a highly increased risk of schizophrenia spectrum disorders.
authors.affiliation: Mental Health Services Copenhagen, Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen, Denmark; Initiative for Integrative Psychiatric Research, iPSYCH, The Lundbeck Foundation, Copenhagen, Denmark;
authors.forename: Anders
authors.initials: A
authors.lastname: Vangkilde
authors.affiliation: Mental Health Services Copenhagen, Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen, Denmark; Initiative for Integrative Psychiatric Research, iPSYCH, The Lundbeck Foundation, Copenhagen, Denmark; line.olsen@regionh.dk.
authors.forename: Line
authors.initials: L
authors.lastname: Olsen
authors.affiliation: Mental Health Services Copenhagen, Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen, Denmark; Initiative for Integrative Psychiatric Research, iPSYCH, The Lundbeck Foundation, Copenhagen, Denmark;
authors.forename: Louise K
authors.initials: LK
authors.lastname: Hoeffding
authors.affiliation: Initiative for Integrative Psychiatric Research, iPSYCH, The Lundbeck Foundation, Copenhagen, Denmark; National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark; Centre for Integrated Register-based Research, CIRRAU, Aarhus University, Aarhus, Denmark;
authors.forename: Carsten B
authors.initials: CB
authors.lastname: Pedersen
authors.affiliation: Initiative for Integrative Psychiatric Research, iPSYCH, The Lundbeck Foundation, Copenhagen, Denmark; National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark;
authors.forename: Preben B
authors.initials: PB
authors.lastname: Mortensen
authors.affiliation: Mental Health Services Copenhagen, Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen, Denmark; Initiative for Integrative Psychiatric Research, iPSYCH, The Lundbeck Foundation, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Werge
authors.affiliation: Initiative for Integrative Psychiatric Research, iPSYCH, The Lundbeck Foundation, Copenhagen, Denmark; National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark;
authors.forename: Betina
authors.initials: B
authors.lastname: Trabjerg
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D015331:Cohort Studies; D015897:Comorbidity; D003718:Denmark / Q000453:epidemiology; D004062:DiGeorge Syndrome / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012042:Registries; D012559:Schizophrenia / Q000453:epidemiology*; D055815:Young Adult
keywords: 22q11 deletion syndrome; health registry; incidence rate; schizophrenia; schizophrenia spectrum disorders