title: Cobaltoceniumethynyl gold(I) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes.
abstract: A cobaltoceniumethynyl gold(i) complex with a triphenylphosphane ligand triggered efficient cytotoxic effects in cancer cells in contrast to a derivative with two cobaltocenium moieties. The complex effectively inhibited the enzyme thioredoxin reductase (TrxR) suggesting this enzyme as a possible biological target. The cellular uptake of both metal fragments of the active complex was studied by atomic absorption spectroscopy and indicated a high biological stability of the complex.
authors.affiliation: Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Center for Chemistry and Biomedicine, Innrain 80-82, A-6020 Innsbruck, Austria. Benno.Bildstein@uibk.ac.at.
authors.forename: S
authors.initials: S
authors.lastname: Vanicek
authors.affiliation: Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Center for Chemistry and Biomedicine, Innrain 80-82, A-6020 Innsbruck, Austria. Benno.Bildstein@uibk.ac.at.
authors.forename: H
authors.initials: H
authors.lastname: Kopacka
authors.affiliation: Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Center for Chemistry and Biomedicine, Innrain 80-82, A-6020 Innsbruck, Austria. Benno.Bildstein@uibk.ac.at.
authors.forename: K
authors.initials: K
authors.lastname: Wurst
authors.affiliation: Institute of Organic Chemistry, University of Innsbruck, Center for Chemistry and Biomedicine, Innrain 80-82, A-6020 Innsbruck, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Vergeiner
authors.affiliation: Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106 Braunschweig, Germany. ingo.ott@tu-bs.de.
authors.forename: S
authors.initials: S
authors.lastname: Kankowski
authors.affiliation: Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106 Braunschweig, Germany. ingo.ott@tu-bs.de.
authors.forename: J
authors.initials: J
authors.lastname: Schur
authors.affiliation: Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Center for Chemistry and Biomedicine, Innrain 80-82, A-6020 Innsbruck, Austria. Benno.Bildstein@uibk.ac.at.
authors.forename: B
authors.initials: B
authors.lastname: Bildstein
authors.affiliation: Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106 Braunschweig, Germany. ingo.ott@tu-bs.de.
authors.forename: I
authors.initials: I
authors.lastname: Ott
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry / Q000494:pharmacology*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006046:Gold / Q000737:chemistry / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013880:Thioredoxin-Disulfide Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D004791:Enzyme Inhibitors; D003035:Cobalt; D006046:Gold; D013880:Thioredoxin-Disulfide Reductase