title: OCT-based crystalline lens topography in accommodating eyes.
abstract: Custom Spectral Domain Optical Coherence Tomography (SD-OCT) provided with automatic quantification and distortion correction algorithms was used to measure anterior and posterior crystalline lens surface elevation in accommodating eyes and to evaluate relationships between anterior segment surfaces. Nine young eyes were measured at different accommodative demands. Anterior and posterior lens radii of curvature decreased at a rate of 0.78 ± 0.18 and 0.13 ± 0.07 mm/D, anterior chamber depth decreased at 0.04 ± 0.01 mm/D and lens thickness increased at 0.04 ± 0.01 mm/D with accommodation. Three-dimensional surface elevations were estimated by subtracting best fitting spheres. In the relaxed state, the spherical term accounted for most of the surface irregularity in the anterior lens (47%) and astigmatism (70%) in the posterior lens. However, in accommodated lenses astigmatism was the predominant surface irregularity (90%) in the anterior lens. The RMS of high-order irregularities of the posterior lens surface was statistically significantly higher than that of the anterior lens surface (x2.02, p<0.0001). There was significant negative correlation in vertical coma (Z3 (-1)) and oblique trefoil (Z3 (-3)) between lens surfaces. The astigmatic angle showed high degree of alignment between corneal surfaces, moderate between corneal and anterior lens surface (~27 deg), but differed by ~80 deg between the anterior and posterior lens surfaces (including relative anterior/posterior lens astigmatic angle shifts (10-20 deg).
authors.affiliation: Instituto de Óptica "Daza de Valdés," Consejo Superior de Investigaciones Científicas, C/Serrano 121, 28006 Madrid, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Pérez-Merino
authors.affiliation: Instituto de Óptica "Daza de Valdés," Consejo Superior de Investigaciones Científicas, C/Serrano 121, 28006 Madrid, Spain.
authors.forename: Miriam
authors.initials: M
authors.lastname: Velasco-Ocana
authors.affiliation: Instituto de Óptica "Daza de Valdés," Consejo Superior de Investigaciones Científicas, C/Serrano 121, 28006 Madrid, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Martinez-Enriquez
authors.affiliation: Instituto de Óptica "Daza de Valdés," Consejo Superior de Investigaciones Científicas, C/Serrano 121, 28006 Madrid, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Marcos
keywords: (100.2960) Image analysis; (110.4500) Optical coherence tomography; (110.6880) Three-dimensional image acquisition; (120.6650) Surface measurements, figure; (330.7322) Visual optics, accommodation; (330.7323) Visual optics, aging changes; (330.7327) Visual optics, ophthalmic instrumentation