title: Nanosuspension: Principles, Perspectives and Practices.
abstract: In the last three decades, nano-sizing of hydrophobic drugs has emerged as one of the most commonly used strategies to overcome their solubility and bioavailability related issues. Nanosuspensions offer versatile features and unique advantages over other approaches that have been utilized for this purpose. The unique inherent properties of nanosuspensions have been explored for a wide variety of applications. Commercial production of stable nanosuspensions has been made possible by the use of techniques such as media milling and high pressure homogenization. This article reviews various techniques being employed for production, characterization, merits and limitations of nanosuspensions and mechanisms that play a role in the physicochemical stability of nanosuspensions. The common strategies applied so far to overcome their stability and commercialization related aspects are also highlighted.
authors.affiliation: School of Pharmaceutical Sciences, Lovely Professional University, Phagwara-144411, Punjab, India. sachin_pharma06@yahoo.co.in.
authors.forename: Sachin Kumar
authors.initials: SK
authors.lastname: Singh
authors.forename: Yogyata
authors.initials: Y
authors.lastname: Vaidya
authors.forename: Monica
authors.initials: M
authors.lastname: Gulati
authors.forename: Sibasis
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: Varun
authors.initials: V
authors.lastname: Garg
authors.forename: Narendra Kumar
authors.initials: NK
authors.lastname: Pandey
mesh_terms: D000818:Animals; D004355:Drug Stability; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D013535:Suspensions / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D013535:Suspensions