title: Characterization of Antibody Bipolar Bridging Mediated by the Human Cytomegalovirus Fc Receptor gp68.
abstract: The human cytomegalovirus glycoprotein gp68 functions as an Fc receptor for host IgGs and can form antibody bipolar bridging (ABB) complexes in which gp68 binds the Fc region of an antigen-bound IgG. Here we show that gp68-mediated endocytosis transports ABB complexes into endosomes, after which the complex is routed to lysosomes, presumably for degradation. These results suggest gp68 contributes to evasion of IgG-mediated immune responses by mediating destruction of host IgG and viral antigens.
authors.affiliation: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
authors.forename: Blaise
authors.initials: B
authors.lastname: Ndjamen
authors.affiliation: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
authors.forename: Devashish S
authors.initials: DS
authors.lastname: Joshi
authors.affiliation: Translational Imaging Center, University of Southern California, Los Angeles, California, USA.
authors.forename: Scott E
authors.initials: SE
authors.lastname: Fraser
authors.affiliation: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA bjorkman@caltech.edu.
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Bjorkman
mesh_terms: D003587:Cytomegalovirus / Q000276:immunology* / Q000502:physiology*; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D017452:Receptors, IgG / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D007074:Immunoglobulin G; D008562:Membrane Glycoproteins; D017452:Receptors, IgG; C464820:UL119-UL118 glycoprotein, Human cytomegalovirus; D014764:Viral Proteins