title: A novel and practical asymmetric synthesis of dapoxetine hydrochloride.
abstract: A novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent.
authors.affiliation: State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, China; School of Pharmacy, Fudan University, No. 826, Zhangheng Rd., Shanghai 201203, China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, China.
authors.forename: Zhenren
authors.initials: Z
authors.lastname: Liu
authors.affiliation: State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Li
authors.affiliation: School of Pharmacy, Fudan University, No. 826, Zhangheng Rd., Shanghai 201203, China.
authors.forename: Deyong
authors.initials: D
authors.lastname: Ye
authors.affiliation: State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, China.
authors.forename: Weicheng
authors.initials: W
authors.lastname: Zhou
keywords: (S)-tert-butanesulfinamide; asymmetric synthesis; dapoxetine hydrochloride; stereoselectivity