title: Adenosine: an endogenous mediator in the pathogenesis of psoriasis.
abstract: It is known that inflammatory and immune responses protect us from the invasion of micro-organisms and eliminate "wastes" from the injured sites, but they may also be responsible for significant tissue damage. Adenosine, as a purine nucleoside, which is produced in inflamed or injured sites, fulfills its role in limiting tissue damage. Although, it may have a pleiotropic effect, which signals it with a proinflammatory state in certain situations, it can be considered a potent anti-inflammatory mediator. The effects of adenosine, which acts through its receptors on T cell, on mast cell and macrophages, on endothelial cells, on neutrophils and dendritic cells, as they indicate TNF-alpha and cytokines, show that this mediator has a central role in the pathogenesis of psoriasis. The way it acts in psoriasis will be reviewed in this study.
authors.affiliation: Caxias do Sul, Caxias do Sul, RS, Brazil.
authors.forename: Moira
authors.initials: M
authors.lastname: Festugato
mesh_terms: D000241:Adenosine / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D008727:Methotrexate / Q000378:metabolism; D011565:Psoriasis / Q000209:etiology* / Q000378:metabolism*
chemical_list: D016207:Cytokines; D007166:Immunosuppressive Agents; D018836:Inflammation Mediators; D000243:Adenosine Deaminase; D000241:Adenosine; D008727:Methotrexate