title: High-Resolution Match Rate of 7/8 and 9/10 or Better for the Be The Match Unrelated Donor Registry.
abstract: Estimation of the National Marrow Donor Program's Be The Match Registry 8/8 (HLA-A, -B, -C, and -DRB1) high-resolution (HR) unrelated donor (URD) match rate was determined in a prior study for each of the 4 most frequent patient race/ethnic groups in the United States: white (WH), Hispanic (HIS), Asian/Pacific Islander (API), and African American (AFA). For patients without an 8/8 HLA-matched URD, a 7/8 match, with a single allele or antigen mismatch, is often accepted by many transplant centers. A follow-up study was designed to determine the 7/8 or better match rate among the 4 major race/ethnic groups, using the same study cohort. Of previously HR tested URDs in the Be The Match Registry, 1344 were randomly selected and treated as pseudo-patients where HR testing was performed to identify a 7/8-matched URD; 98% of WH and over 80% of non-WH race/ethnic groups (HIS, API, and AFA) had at least a 7/8 match identified. In most cases after first testing to identify an 8/8-matched URD, a 7/8-matched URD was identified after typing just 1 URD. Extending criteria to identify a 9/10 match (included HLA-DQB1) showed the 9/10 absolute match rate decreased between 14% and 21% from the 7/8 match rate for the non-WH groups. This study provides a baseline 7/8 and 9/10 or better HLA match rate that can be further supplemented using the additional worldwide URD inventory. URD match rate information can equip centers in clinical planning and the education of patients seeking a life-saving therapy.
authors.affiliation: National Marrow Donor Program, Minneapolis, Minnesota. Electronic address: kbuck@nmdp.org.
authors.forename: Kelly
authors.initials: K
authors.lastname: Buck
authors.affiliation: National Marrow Donor Program, Minneapolis, Minnesota.
authors.forename: Kim
authors.initials: K
authors.lastname: Wadsworth
authors.affiliation: National Marrow Donor Program, Minneapolis, Minnesota.
authors.forename: Michelle
authors.initials: M
authors.lastname: Setterholm
authors.affiliation: National Marrow Donor Program, Minneapolis, Minnesota.
authors.forename: Martin
authors.initials: M
authors.lastname: Maiers
authors.affiliation: National Marrow Donor Program, Minneapolis, Minnesota.
authors.forename: Dennis
authors.initials: D
authors.lastname: Confer
authors.affiliation: C.W. Bill Young Marrow Donor Recruitment and Research Program, Department of Defense, Bone Marrow Research Directorate, Naval Medical Research Center, Department of the Navy, Washington, DC.
authors.forename: Robert
authors.initials: R
authors.lastname: Hartzman
authors.affiliation: DKMS German Bone Marrow Donor Center, Tübingen, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Schmidt
authors.affiliation: HistoGenetics LLC, Ossining, New York.
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Yang
authors.affiliation: National Marrow Donor Program, Minneapolis, Minnesota.
authors.forename: Jason
authors.initials: J
authors.lastname: Dehn
mesh_terms: D000328:Adult; D000483:Alleles; D016026:Bone Marrow Transplantation; D005260:Female; D015870:Gene Expression; D006086:Graft vs Host Disease / Q000208:ethnology / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D006680:HLA Antigens / Q000145:classification* / Q000235:genetics / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000208:ethnology*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D044469:Racial Groups; D012042:Registries; D012189:Retrospective Studies; D035781:Siblings; D014184:Transplantation, Homologous; D061349:Unrelated Donors
chemical_list: D006680:HLA Antigens
keywords: Donor registry; HLA matching; Marrow; Stem cell; Transplantation