title: Online detection of tonic-clonic seizures in pediatric patients using ECG and low-complexity incremental novelty detection.
abstract: Home monitoring of refractory epilepsy patients has become of more interest the last couple of decades. A biomedical signal that can be used for online seizure detection at home is the electrocardiogram. Previous studies have shown that tonic-clonic seizures are most often accompanied with a strong heart rate increase. The main issue however is the strong patient-specific behavior of the ictal heart rate features, which makes it hard to make a patient-independent seizure detection algorithm. A patient-specific algorithm might be a solution, but existing methods require the availability of data of several seizures, which would make them inefficient in case the first seizure only occurs after a couple of days. Therefore an online method is described here that automatically converts from a patient-independent towards a patient-specific algorithm as more patient-specific data become available. This is done by using online feedback from the users to previously given alarms. By using a simplified one-class classifier, no seizure training data needs to be available for a good performance. The method is already able to adapt to the patient-specific characteristics after a couple of hours, and is able to detect 23 of 24 seizures longer than 10s, with an average of 0.38 false alarms per hour. Due to its low-complexity, it can be easily used for wearable seizure detection at home.
authors.forename: Thomas
authors.initials: T
authors.lastname: De Cooman
authors.forename: Anouk
authors.initials: A
authors.lastname: Van de Vel
authors.forename: Berten
authors.initials: B
authors.lastname: Ceulemans
authors.forename: Lieven
authors.initials: L
authors.lastname: Lagae
authors.forename: Bart
authors.initials: B
authors.lastname: Vanrumste
authors.forename: Sabine
authors.initials: S
authors.lastname: Van Huffel
mesh_terms: D000465:Algorithms; D002648:Child; D004562:Electrocardiography; D004569:Electroencephalography; D004830:Epilepsy, Tonic-Clonic; D006339:Heart Rate; D006801:Humans; D012640:Seizures