title: Association between high-sensitive troponin I and coronary artery calcification in a Danish general population.
abstract: BACKGROUND
  High-sensitive troponin I (hs-TnI) is an individual predictor of future cardiovascular disease (CVD). However, the relationship between hs-TnI and coronary artery calcification (CAC) as determined by computed tomography (CT) has not previously been investigated in a general population.
  
  
  METHODS
  1173 randomized, middle-aged subjects without known CVD underwent a non-contrast cardiac-CT scan for CAC determination. Hs-TnI was detected using ARCHITECT STAT High Sensitive Troponin-I immunoassay. Total 10-year cardiovascular mortality risk was estimated using HeartScore. The relationship between hs-TnI and CAC was assessed using logistic regression analyses and receiver operating characteristic curves (ROC).
  
  
  RESULTS
  Concentrations of hs-TnI above the limit of detection were measured in 89.3% of all subjects. Presence of CAC (Agatston score >0) was detected in 29% in the lowest hs-TnI quartile compared with 55% in the highest, with a stepwise increase over the quartiles. In fully adjusted regression models with dichotomous CAC outcomes, hs-TnI was able to predict presence of CAC (OR: 1.25, 95% CI: 1.03-1.51, p = 0.025) and an Agatston score >100 (OR: 1.36, 95% CI: 1.08-1.71, p = 0.009). Subjects in the fourth hs-TnI quartile had an increased risk for presence of CAC (OR: 1.56, 95% CI: 1.06-2.26, p = 0.024) and for an Agatston score >100 (OR: 1.82, 95% CI: 1.04-3.18, p = 0.035), when compared with the first quartile. Addition of hs-TnI to HeartScore improved the ROCAUC from 0.671 to 0.695 (p < 0.0001).
  
  
  CONCLUSIONS
  Hs-TnI was associated with CAC in a Danish middle-aged population without previously known CVD. This is a step towards understanding hs-TnI as a risk marker for CVD.
authors.affiliation: Department of Cardiology, Odense University Hospital, Sdr. Boulevard 29, Dk-5000, Odense C, Denmark. Electronic address: fredrik.anders.olsson@rsyd.dk.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Olson
authors.affiliation: Department of Cardiology, Odense University Hospital, Sdr. Boulevard 29, Dk-5000, Odense C, Denmark.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Engborg
authors.affiliation: Department of Cardiology, Odense University Hospital, Sdr. Boulevard 29, Dk-5000, Odense C, Denmark.
authors.forename: Mette H
authors.initials: MH
authors.lastname: Grønhøj
authors.affiliation: Department of Cardiology, Sydvestjyst Hospital, Finsensgade 35, DK-6700, Esbjerg, Denmark.
authors.forename: Niels P
authors.initials: NP
authors.lastname: Sand
authors.affiliation: Department of Cardiology, Svendborg Hospital, Valdemarsgade 53, DK-5700, Svendborg, Denmark.
authors.forename: Jess
authors.initials: J
authors.lastname: Lambrechtsen
authors.affiliation: Department of Cardiology, Vejle Hospital, Kabbeltoft 25, DK-7100, Vejle, Denmark.
authors.forename: Flemming H
authors.initials: FH
authors.lastname: Steffensen
authors.affiliation: Department of Clinical Biochemistry, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense C, Denmark.
authors.forename: Mads
authors.initials: M
authors.lastname: Nybo
authors.affiliation: Department of Nuclear Medicine, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense C, Denmark.
authors.forename: Oke
authors.initials: O
authors.lastname: Gerke
authors.affiliation: Department of Cardiology, Odense University Hospital, Sdr. Boulevard 29, Dk-5000, Odense C, Denmark.
authors.forename: Hans
authors.initials: H
authors.lastname: Mickley
authors.affiliation: Department of Cardiology, Odense University Hospital, Sdr. Boulevard 29, Dk-5000, Odense C, Denmark. Electronic address: Axel.Diederichsen@rsyd.dk.
authors.forename: Axel C P
authors.initials: AC
authors.lastname: Diederichsen
mesh_terms: D002114:Calcinosis / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D014057:Tomography, X-Ray Computed; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I
keywords: Agatston score; Cardiovascular risk; Coronary artery calcification; Coronary artery disease; DanRisk; General population; High-sensitive troponin I