title: In silico modeling techniques for predicting the tertiary structure of human H4 receptor.
abstract: First cloned in 2000, the human Histamine H4 Receptor (hH4R) is the last member of the histamine receptors family discovered so far, it belongs to the GPCR super-family and is involved in a wide variety of immunological and inflammatory responses. Potential hH4R antagonists are proposed to have therapeutic potential for the treatment of allergies, inflammation, asthma and colitis. So far, no hH4R ligands have been successfully introduced to the pharmaceutical market, which creates a strong demand for new selective ligands to be developed. in silico techniques and structural based modeling are likely to facilitate the achievement of this goal. In this review paper we attempt to cover the fundamental concepts of hH4R structure modeling and its implementations in drug discovery and development, especially those that have been experimentally tested and to highlight some ideas that are currently being discussed on the dynamic nature of hH4R and GPCRs, in regards to computerized techniques for 3-D structure modeling.
authors.affiliation: Drug Discovery and Informatics Lab, QRC-Qasemi Research Center, Al-Qasemi Academic College, P.O.B. 124, Baka El-Garbiah 30100, Israel.
authors.forename: Hilal
authors.initials: H
authors.lastname: Zaid
authors.affiliation: modeling techniques.
authors.forename: Jamal
authors.initials: J
authors.lastname: Raiyn
authors.affiliation: Drug Discovery Informatics Lab, QRC - Qasemi Research Center, Al-Qasemi Academic College.
authors.forename: Midhat
authors.initials: M
authors.lastname: Osman
authors.affiliation: Drug Discovery Informatics Lab, QRC.
authors.forename: Mizied
authors.initials: M
authors.lastname: Falah
authors.affiliation: Drug Discovery Informatics Lab, QRC - Qasemi Research Center.
authors.forename: Samer
authors.initials: S
authors.lastname: Srouji
authors.affiliation: Science Education Department, Al-Qasemi Academic College, Baka EL-Garbiah 30100, Israel, a_rayan@qsm.ac.il.
authors.forename: Anwar
authors.initials: A
authors.lastname: Rayan
mesh_terms: D000595:Amino Acid Sequence; D003198:Computer Simulation; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D011968:Receptors, Histamine / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid
chemical_list: D011968:Receptors, Histamine