title: Reduction of CD4(+)CD25(+) regulatory T-cells in migraine: Is migraine an autoimmune disorder?
abstract: Migraine is believed to be a chronic neurological disorder with the exact aetiology being unknown. But, there is a debate on the role of immune dysfunction in migraine pathophysiology. Hence, authors made a debut attempt to explore the link between lymphocyte subset populations and migraine. A significant increase in CD4(+) and decrease in CD8(+) population were observed in migraine patients compared to healthy volunteers. Interestingly, the immunoregulator CD4(+)CD25(+) levels were less in migraine patients compared to the healthy volunteers. The results of the present study indicate that failure of immunoregulation could be implicated in the pathophysiology of migraine.
authors.affiliation: Department of Pharmacy, Annamalai University, Annamalai Nagar, India.
authors.forename: Murugesan
authors.initials: M
authors.lastname: Arumugam
authors.affiliation: Department of Pharmacy, Annamalai University, Annamalai Nagar, India. Electronic address: vapartha@yahoo.com.
authors.forename: Varadarajan
authors.initials: V
authors.lastname: Parthasarathy
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000097:blood*; D008297:Male; D008881:Migraine Disorders / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers; C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit
keywords: Autoimmunity; CD4(+); CD4(+)D25(+); CD4:CD8 ratio; CD8(+); Migraine