title: Acetazolamide in vestibular migraine prophylaxis: a retrospective study.
abstract: The aim of this study is to check the efficacy of acetazolamide in the prophylaxis of vestibular migraine (VM). Treatment options in VM are mainly based on migraine guidelines. We tried to assess the efficacy of acetazolamide in these patients depending on clinical similarities with episodic ataxia type 2 and familial hemiplegic migraine responding to the drug. This is a retrospective cohort study. Among 50 patients with VM and prescribed acetazolamide 500 mg/day, 39 patients were studied as five had been lost on follow-up and six had stopped taking the drug due to side effects. Vertigo and headache frequency determined by number of attacks per month, and the severity determined by visual analog scales measured in centimeters from 0 to 10 were collected from the records. Initial reported figures for frequency and severity were compared with the results gathered after 3 months of treatment. The results were compared. Acetazolamide was effective in reducing both the frequency and severity of vertigo and headache attacks and this effect was more prominent for vertigo frequency and severity.
authors.affiliation: Department of Neurology, Ege University Medical School, Bornova, İzmir, 35100, Turkey. nese.celebisoy@ege.edu.tr.
authors.forename: Neşe
authors.initials: N
authors.lastname: Çelebisoy
authors.affiliation: Department of Neurology, Ege University Medical School, Bornova, İzmir, 35100, Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: Gökçay
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Ege University Medical School, Bornova, İzmir, 35100, Turkey.
authors.forename: Ceyda
authors.initials: C
authors.lastname: Karahan
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Ege University Medical School, Bornova, İzmir, 35100, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Bilgen
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Ege University Medical School, Bornova, İzmir, 35100, Turkey.
authors.forename: Tayfun
authors.initials: T
authors.lastname: Kirazlı
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ege University Medical School, Bornova, İzmir, 35100, Turkey.
authors.forename: Hale
authors.initials: H
authors.lastname: Karapolat
authors.affiliation: Department of Biostatistics and Medical Informatics, Ege University Medical School, Bornova, İzmir, 35100, Turkey.
authors.forename: Timur
authors.initials: T
authors.lastname: Köse
mesh_terms: D000086:Acetazolamide / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use*; D005260:Female; D006261:Headache / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D010147:Pain Measurement; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014717:Vertigo / Q000188:drug therapy* / Q000209:etiology; D014722:Vestibule, Labyrinth
chemical_list: D000700:Analgesics; D000086:Acetazolamide
keywords: Acetazolamide; Prophylaxis; Vestibular migraine