title: Analysis of Postsurgical Health-Related Quality of Life and Quality of Voice of Patients With Laryngeal Carcinoma.
abstract: This study aims to analyze the postsurgical health-related quality of life (HRQOL) and quality of voice (QOV) of patients with laryngeal carcinoma with an expectation of improving the treatment and HRQOL of these patients. Based on the collection of information of patients with laryngeal carcinoma regarding clinical characteristics (age, TNM stage, with or without laryngeal preservation and/or neck dissection, with or without postoperative irradiation and/or chemotherapy, etc.), QOV using Voice Handicap Index (VIH) scale and HRQOL using EORTC QLQ-C30 and EORTCQLQ-H&N35 scales, the differences of postsurgical HRQOL related to their clinical characteristics were analyzed using univariate nonparametric tests, the main factors impacting the postsurgical HRQOL were analyzed using regression analyses (generalized linear models) and the correlation between QOV and HRQOL analyzed using spearman correlation analysis. A total of 92 patients were enrolled in this study, on whom the use of EORTC QLQ-C30, EORTC QLQ-H&N35 and VHI scales revealed that: the differences of HRQOL were significant among patients with different ages, TNM stages, and treatment modalities; the main factors impacting the postsurgical HRQOL were pain, speech disorder, and dry mouth; and QOV was significantly correlated with HRQOL. For the patients with laryngeal carcinoma included in our study, the quality of life after open surgeries were impacted by many factors predominated by pain, speech disorder, and dry mouth. It is suggested that doctors in China do more efforts on the patients' postoperative pain and xerostomia management and speech rehabilitation with the hope of improving the patients' quality of life.
authors.affiliation: From the Otorhinolaryngology Hospital, Otorhinolaryngology Institute, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China (JL, JL W(Jieli Wu), KX L(Kexing Lv), YW, HT, AJ, ZW, WW, WL); Tianyou Hospital Affiliated to Tongji University, Shanghai, China (JL, KC L(Kaichun Li)); Otorhinolaryngology Institute, Meizhou People's Hospital, Meizhou, Guangdong, China (JW); and The Fourth People's Hospital of Shenzhen (Affiliated Futian Hospital of Guangdong Medical College), Shenzhen, China (XL).
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.forename: Jieli
authors.initials: J
authors.lastname: Wu
authors.forename: Kexing
authors.initials: K
authors.lastname: Lv
authors.forename: Kaichun
authors.initials: K
authors.lastname: Li
authors.forename: Jianhui
authors.initials: J
authors.lastname: Wu
authors.forename: Yihui
authors.initials: Y
authors.lastname: Wen
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Li
authors.forename: Haocheng
authors.initials: H
authors.lastname: Tang
authors.forename: Aiyun
authors.initials: A
authors.lastname: Jiang
authors.forename: Zhangfeng
authors.initials: Z
authors.lastname: Wang
authors.forename: Weiping
authors.initials: W
authors.lastname: Wen
authors.forename: Wenbin
authors.initials: W
authors.lastname: Lei
mesh_terms: D000367:Age Factors; D017024:Chemotherapy, Adjuvant; D002681:China; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000523:psychology / Q000601:surgery* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010146:Pain / Q000453:epidemiology / Q000523:psychology; D011183:Postoperative Complications / Q000453:epidemiology / Q000523:psychology*; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant; D013064:Speech Disorders / Q000453:epidemiology / Q000523:psychology; D014831:Voice; D014987:Xerostomia / Q000453:epidemiology / Q000523:psychology