title: Metabolite analysis in sepsis through conditional independence maps.
abstract: Sepsis is the response of the host to an infection that produces lesions in its own organs and tissues. Despite the great advances in modern medicine, including vaccines, antibiotics and intensive care, it is still the primary cause of death due to infection. Sepsis may result in shock, multi-organic failure and death unless there is a rapid identification of the infection and timely administration of treatment. Its mortality rates can reach up to 45.7% for septic shock, its most acute manifestation. In this paper we also present these conditional independence maps in the context of algebraic statistics. The results of this analysis over a small cohort of nine patients at three different times (ICU admission, 48h and ICU discharge) showed that there is a significant interaction between C3- DC / C4-OH (Hydroxybutyrylcarnitine) and C5 (Valerylcarnitin) for the three time snapshots. We also found a significant interaction between C3-DC / C4-OH (Hydroxybutyrylcarnitine) and C5 (Valerylcarnitine) and Isoleucine (Ile) at 48h and ICU discharge.
authors.forename: Vicent
authors.initials: V
authors.lastname: Ribas Ripoll
authors.forename: Eduardo
authors.initials: E
authors.lastname: Romay
authors.forename: Laura
authors.initials: L
authors.lastname: Brunelli
authors.forename: Roberta
authors.initials: R
authors.lastname: Pastorelli
authors.forename: Gemma
authors.initials: G
authors.lastname: Goma
authors.forename: Ana
authors.initials: A
authors.lastname: Navas
authors.forename: Antoni
authors.initials: A
authors.lastname: Artigas
authors.forename: Ricard
authors.initials: R
authors.lastname: Ferrer
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001499:Bayes Theorem; D015415:Biomarkers / Q000378:metabolism; D002331:Carnitine / Q000031:analogs & derivatives / Q000097:blood; D003196:Computer Graphics; D003422:Critical Care; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007532:Isoleucine / Q000097:blood; D007902:Length of Stay; D008297:Male; D008390:Markov Chains; D055432:Metabolomics; D008875:Middle Aged; D015233:Models, Statistical; D010351:Patient Discharge; D011336:Probability; D011446:Prospective Studies; D018805:Sepsis / Q000097:blood* / Q000401:mortality*; D012772:Shock, Septic
chemical_list: D015415:Biomarkers; C513202:hydroxybutyrylcarnitine; D007532:Isoleucine; D002331:Carnitine