title: Nafamostat mesilate as a regional anticoagulant in patients with bleeding complications during extracorporeal membrane oxygenation.
abstract: OBJECTIVE
  Anticoagulation is mandatory for extracorporeal membrane oxygenation (ECMO), but systemic heparinization, which has been most widely used as an anticoagulant, has been associated with bleeding complications. The present study reviewed the usefulness and safety of nafamostat mesilate as a regional anticoagulant in patients with bleeding complication during ECMO.
  
  
  METHODS
  We retrospectively reviewed the record of 13 cases. The nafamostat mesilate dose was regulated to maintain the activated clotting time (ACT) or activated partial thromboplastin time (aPTT) values within an adequate range at the ECMO reinfusion route. ACT or aPTT values in blood samples from the ECMO circuit and from the patients were measured simultaneously and consecutively.
  
  
  RESULTS
  We measured the ACT value in 6 cases and aPTT in 7 cases. The bleeding complications were treated in 11 cases. When we compared the difference in 2 anticoagulation values (ACT and aPTT) between the 2 blood samples, one taken from ECMO and the other from patients, mean anticoagulation values of blood from patients were lower than those from ECMO circuit in 11 cases. With respect to the type of ECMO reinfusion mode, the difference was significant only in veno-arterial mode ECMO group (p&lt;0.001).
  
  
  CONCLUSIONS
  Nafamostat mesilate, with which we can reduce anticoagulation values of patient to a safe level without losing the ECMO anticoagulation values is expected to be useful as a regional anticoagulant in patients with bleeding complications or a high risk of bleeding during ECMO.
authors.affiliation: Department of Internal Medicine, Inje University, College of Medicine, Haeundae Paik Hospital, Busan - Republic of Korea.
authors.forename: Jin-Han
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Anesthesiology and Pain medicine, Inje University, College of Medicine, Haeundae Paik Hospital, Busan - Republic of Korea.
authors.forename: Charles
authors.initials: C
authors.lastname: Her
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Inje University, College of Medicine, Haeundae Paik Hospital, Busan - Republic of Korea.
authors.forename: Ho-Ki
authors.initials: HK
authors.lastname: Min
authors.affiliation: Department of Internal Medicine, Inje University, College of Medicine, Haeundae Paik Hospital, Busan - Republic of Korea.
authors.forename: Dong-Kie
authors.initials: DK
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Inje University, College of Medicine, Haeundae Paik Hospital, Busan - Republic of Korea.
authors.forename: Si-Hyung
authors.initials: SH
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Inje University, College of Medicine, Haeundae Paik Hospital, Busan - Republic of Korea.
authors.forename: Hang-Jea
authors.initials: HJ
authors.lastname: Jang
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D001550:Benzamidines; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects*; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D001550:Benzamidines; D006146:Guanidines; C032855:nafamostat