title: Copper-catalyzed tandem Ullmann type C-N coupling and dehydrative cyclization: synthesis of imidazo[1,2-c]quinazolines.
abstract: A simple and efficient one-pot protocol has been demonstrated for the synthesis of imidazo[1,2-c]quinazoline derivatives through a copper catalyzed tandem reaction between substituted 2-(2-bromophenyl)-1H-imidazoles and formamide. The synthetic protocol involves initial Ullmann-type C-N coupling followed by intramolecular dehydrative cyclization. The method uses readily available 2-(2-bromophenyl)-1H-imidazoles as the starting materials to afford imidazo[1,2-c]quinazolines in moderate to good yields and provided 610 mg (71%) yield of 3a from a gram scale reaction.
authors.affiliation: Department of Chemistry, Birla Institute of Technology and Science, Pilani, 333031 Rajasthan, India. anilkumar@pilani.bits-pilani.ac.in.
authors.forename: Nitesh K
authors.initials: NK
authors.lastname: Nandwana
authors.affiliation: Department of Chemistry, Birla Institute of Technology and Science, Pilani, 333031 Rajasthan, India. anilkumar@pilani.bits-pilani.ac.in.
authors.forename: Shiv
authors.initials: S
authors.lastname: Dhiman
authors.affiliation: Department of Chemistry, Birla Institute of Technology and Science, Pilani, 333031 Rajasthan, India. anilkumar@pilani.bits-pilani.ac.in.
authors.forename: Ganesh M
authors.initials: GM
authors.lastname: Shelke
authors.affiliation: Department of Chemistry, Birla Institute of Technology and Science, Pilani, 333031 Rajasthan, India. anilkumar@pilani.bits-pilani.ac.in.
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar