title: Roles of Presynaptic NMDA Receptors in Neurotransmission and Plasticity.
abstract: Presynaptic NMDA receptors (preNMDARs) play pivotal roles in excitatory neurotransmission and synaptic plasticity. They facilitate presynaptic neurotransmitter release and modulate mechanisms controlling synaptic maturation and plasticity during formative periods of brain development. There is an increasing understanding of the roles of preNMDARs in experience-dependent synaptic and circuit-specific computation. In this review we summarize the latest understanding of compartment-specific expression and function of preNMDARs, and how they contribute to synapse-specific and circuit-level information processing.
authors.affiliation: Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Banerjee
authors.affiliation: Allen Institute for Brain Science, Seattle, WA, USA.
authors.forename: Rylan S
authors.initials: RS
authors.lastname: Larsen
authors.affiliation: Department of Cell Biology and Physiology, Neuroscience Center, and Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, USA. Electronic address: bphilpot@med.unc.edu.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Philpot
authors.affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. Electronic address: op210@cam.ac.uk.
authors.forename: Ole
authors.initials: O
authors.lastname: Paulsen
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D017661:Receptors, Presynaptic / Q000502:physiology*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D017661:Receptors, Presynaptic
keywords: NMDA receptors; cortex; development; synaptic plasticity