title: [Newly developed drugs to improve bone strength].
abstract: Drugs for the treatment of osteoporosis improve bone strength by inhibiting bone resorption or stimulating bone formation. New drugs already using some action mechanism such as bisphosphonate or parathyroid hormone-related peptide analog are being developed in Japan. In addition, new drugs with new action mechanisms such as cathepsin K inhibitor or anti-sclerostin antibody are also being developed and it has been reported that they have good potential to increase bone mineral density.
authors.affiliation: School of Health Science and Rehabilitation Division, Tottori University, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hagino
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000368:Aged; D000906:Antibodies / Q000494:pharmacology / Q000627:therapeutic use; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000494:pharmacology / Q000627:therapeutic use; D019485:Bone Morphogenetic Proteins / Q000276:immunology; D001862:Bone Resorption / Q000517:prevention & control; D056657:Cathepsin K / Q000037:antagonists & inhibitors; D002986:Clinical Trials as Topic; D004164:Diphosphonates / Q000494:pharmacology / Q000627:therapeutic use; D055808:Drug Discovery / Q000639:trends*; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D018565:Food-Drug Interactions; D005819:Genetic Markers / Q000276:immunology; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy* / Q000378:metabolism; D044162:Parathyroid Hormone-Related Protein / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000906:Antibodies; D050071:Bone Density Conservation Agents; D019485:Bone Morphogenetic Proteins; D004164:Diphosphonates; D004791:Enzyme Inhibitors; D005819:Genetic Markers; D044162:Parathyroid Hormone-Related Protein; C422903:SOST protein, human; D056657:Cathepsin K