title: Genetic variants of the class A scavenger receptor gene are associated with essential hypertension in Chinese.
abstract: BACKGROUND
  The class A scavenger receptor, which is encoded by the macrophage scavenger receptor 1 (MSR1) gene, is a pattern recognition receptor (PPR) primarily expressed in macrophages. It has been reported that genetic polymorphisms of MSR1 are significantly associated with many cardiovascular events. However, whether it links genetically to essential hypertension (EH) in Chinese is not defined.
  
  
  METHODS
  We performed an independent case-control study in a Chinese population consisting of 617 EH cases and 620 controls by genotyping three single nucleotide polymorphisms (SNPs) of MSR1.
  
  
  RESULTS
  We found that rs13306541 and rs3747531 were significantly associated with an increased risk of EH with per allele odds ratio (OR) of 1.63 [95% confidence interval (CI): 1.27-2.09; P<0.001] and 1.29 (95% CI: 1.09-1.52; P=0.003), respectively. Individuals with 2-4 risk alleles had a 2.03-fold (95% CI: 1.48-2.78) increased risk of EH compared with those having none of the risk alleles (P for trend <0.001).
  
  
  CONCLUSIONS
  Our results indicate that genetic variants of MSR1 may serve as predictive markers for the risk of EH in combination with traditional risk factors of EH in Chinese population.
authors.affiliation: 1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: 1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Han
authors.affiliation: 1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
authors.forename: Zihe
authors.initials: Z
authors.lastname: Yan
authors.affiliation: 1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
authors.forename: Qichen
authors.initials: Q
authors.lastname: Cui
authors.affiliation: 1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
authors.forename: Yuhai
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: 1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
authors.forename: Mingzhu
authors.initials: M
authors.lastname: Gao
authors.affiliation: 1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.affiliation: 1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Hua
authors.affiliation: 1 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 2 Department of Cardiology Surgery, Wuxi Third People's Hospital, Wuxi 214000, China, 3 Department of Cardiology Surgery, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Huang
keywords: Chinese population; Class A scavenger receptor gene; essential hypertension (EH); single nucleotide polymorphisms (SNPs)