title: 3D axonal network coupled to Microelectrode Arrays: A simulation model to study neuronal dynamics.
abstract: Action Potentials in a neuron are generated and propagated by exchange of ions through the membrane. The model of Hodgkin and Huxley (HH) describes these time-dependent complex ion dynamics. We have implemented the FitzHugh-Nagumo model, one of the simplified versions of HH model on a pyramidal neuron with branches of axons to study the spontaneous activity of neurons. The network is then coupled to Micro-Electrode Arrays to record the extracellular potential in a neurochip environment. This in silico model is used to study the coupling of AP with the electrodes. Such a model is also a first step to investigate the morphological influence of neurons on their signaling properties.
authors.forename: Revathi
authors.initials: R
authors.lastname: Appali
authors.forename: Kiran K
authors.initials: KK
authors.lastname: Sriperumbudur
authors.forename: Ursula
authors.initials: U
authors.lastname: van Rienen
mesh_terms: D000200:Action Potentials / Q000502:physiology; D001369:Axons / Q000502:physiology; D020342:Finite Element Analysis; D008839:Microelectrodes; D008959:Models, Neurological; D017966:Pyramidal Cells / Q000502:physiology*