title: Chitosan solutions as injectable systems for dermal filler applications: Rheological characterization and biological evidence.
abstract: A new generation of dermal filler for wrinkle filler based on chitosan was compared to current hyaluronic acid-based dermal fillers by using a new rheological performance criterion based on viscosity during injection related to Newtonian viscosity. In addition an in vivo evaluation was performed for preclinical evidence of chitosan use as dermal filler. In this way, biocompatibility and dermis reconstruction was evaluated on a pig model.
authors.forename: C
authors.initials: C
authors.lastname: Halimi
authors.forename: A
authors.initials: A
authors.lastname: Montembault
authors.forename: A
authors.initials: A
authors.lastname: Guerry
authors.forename: T
authors.initials: T
authors.lastname: Delair
authors.forename: E
authors.initials: E
authors.lastname: Viguier
authors.forename: R
authors.initials: R
authors.lastname: Fulchiron
authors.forename: L
authors.initials: L
authors.lastname: David
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D000067548:Dermal Fillers / Q000737:chemistry*; D020405:Dermis / Q000473:pathology / Q000502:physiology; D006820:Hyaluronic Acid / Q000737:chemistry; D007279:Injections, Subcutaneous; D012038:Regeneration; D012212:Rheology; D033081:Shear Strength; D013552:Swine; D014783:Viscosity
chemical_list: D001672:Biocompatible Materials; D000067548:Dermal Fillers; D006820:Hyaluronic Acid; D048271:Chitosan