title: Quantitative Susceptibility Mapping of Intracerebral Hemorrhages at Various Stages.
abstract: To investigate the magnetic susceptibility of intracerebral hemorrhages (ICH) at various stages by applying quantitative susceptibility mapping (QSM).
  
  
  
  Blood susceptibility was measured serially using QSM after venous blood withdrawal from healthy subjects. Forty-two patients who provided written consent were recruited in this Institutional Review Board-approved study. Gradient echo magnetic resonance imaging (MRI) data of the 42 patients (17 females; 64 ± 12 years) with ICH were processed with QSM. The susceptibilities of various blood products within hematomas were measured on QSM.
  
  
  
  Blood susceptibility continually increased and reached a plateau 96 hours after venous blood withdrawal. Hematomas at all stages were consistently hyperintense on QSM. Susceptibility was 0.57 ± 0.48, 1.30 ± 0.33, 1.14 ± 0.46, 0.40 ± 0.13, and 0.71 ± 0.31 ppm for hyperacute, acute, early subacute, late subacute, and chronic stages of hematomas, respectively. The susceptibility decrease from early subacute (1.14 ppm) to late subacute (0.4 ppm) was significant (P < 0.01).
  
  
  
  QSM reveals positive susceptibility in hyperacute hematomas, indicating that even at their hyperacute stage, deoxyhemoglobin may exist throughout the hematoma volume, not just at its rim, as seen on conventional T2* imaging. QSM also reveals a reduction of susceptibility from early subacute to late subacute ICH, suggesting that methemoglobin concentration decreases at the late subacute stage. J. Magn. Reson. Imaging 2016;44:420-425.
authors.affiliation: Department of Radiology, Yueyang Hospital of Integrated Traditional Chinese & Western Medicine, Shanghai, China.
authors.forename: Shixin
authors.initials: S
authors.lastname: Chang
authors.affiliation: Department of Radiology, Weill Cornell Medical College, New York, New York, USA.|Department of Biomedical Engineering, Cornell University, New York, New York, USA.
authors.forename: Jingwei
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Weill Cornell Medical College, New York, New York, USA.
authors.forename: Tian
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Radiology, Weill Cornell Medical College, New York, New York, USA.
authors.forename: Apostolos John
authors.initials: AJ
authors.lastname: Tsiouris
authors.affiliation: Department of Surgery, Weill Cornell Medical College, New York, New York, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Shou
authors.affiliation: Department of Radiology, Weill Cornell Medical College, New York, New York, USA.
authors.forename: Thanh
authors.initials: T
authors.lastname: Nguyen
authors.affiliation: Department of Neurology, Weill Cornell Medical College, New York, New York, USA.
authors.forename: Dana
authors.initials: D
authors.lastname: Leifer
authors.affiliation: Department of Radiology, Weill Cornell Medical College, New York, New York, USA.|Department of Biomedical Engineering, Cornell University, New York, New York, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiology, Weill Cornell Medical College, New York, New York, USA.
authors.forename: Ilhami
authors.initials: I
authors.lastname: Kovanlikaya
mesh_terms: D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging* / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D060526:Magnetic Fields; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
keywords: CT; QSM; intracerebral hemorrhage; magnetic susceptibility