title: Pathology and Genetics of Syndromic Gastric Polyps.
abstract: Gastric polyps are found in 1% to 4% of patients undergoing gastroscopy. The vast majority are sporadic, but some gastric polyps indicate an underlying syndrome. Gastric polyps can manifest in each of the gastrointestinal polyposis syndromes, including the recently described gastric adenocarcinoma and proximal polyposis of the stomach syndrome. In addition, gastric polyps occur in Lynch syndrome and in a few rare conditions that are not primarily gastrointestinal. While some of these syndromes are clearly associated with an increased risk of gastric cancer, others are not. Interestingly, even in disorders with a well-established risk of gastric cancer, the neoplastic potential and the precursor status of these gastric polyps are not always clear. Although rare, recognition of syndromic gastric polyps is important for individual patient management. These conditions also serve as important models to study gastric homeostasis and gastric tumorigenesis.
authors.affiliation: University Medical Center Utrecht, Utrecht, The Netherlands l.a.a.brosens@umcutrecht.nl.
authors.forename: Lodewijk A A
authors.initials: LA
authors.lastname: Brosens
authors.affiliation: The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Laura D
authors.initials: LD
authors.lastname: Wood
authors.affiliation: University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: G Johan
authors.initials: GJ
authors.lastname: Offerhaus
authors.affiliation: The Ohio State University Wexner Medical Center, Columbus, OH, USA.
authors.forename: Christina A
authors.initials: CA
authors.lastname: Arnold
authors.affiliation: Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Dora
authors.initials: D
authors.lastname: Lam-Himlin
authors.affiliation: The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Francis M
authors.initials: FM
authors.lastname: Giardiello
authors.affiliation: The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Montgomery
mesh_terms: D018256:Adenomatous Polyps / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*
keywords: Cronkhite-Canada syndrome; Lynch syndrome; McCune-Albright syndrome; Peutz-Jeghers; familial adenomatous polyposis; gastric cancer; gastric polyp; hamartomatous polyp; juvenile polyposis; neurofibromatosis type 1; polyposis