title: Metabolic scaling predicts posthepatectomy liver regeneration after accounting for hepatocyte hypertrophy.
abstract: We adapted a mathematical model of posthepatectomy liver regeneration using data from a subset of patients in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study. The original model addressed changes in the number of quiescent, primed, and proliferating cells. Our adapted model takes into account hypertrophy of primed and replicating cells, and it is better able to predict liver volume. In addition, by building off the hypothesis that cell cycle parameters are approximately the same across all mammals, we found that changing only a single parameter characterizing metabolic load could model liver regeneration in 5 species of mammals. In conclusion, we improved a mathematical model of liver regeneration, predicted mammalian liver regeneration based on metabolism, and found correlations between model parameters and physiological measurements from liver donors.
authors.affiliation: Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.
authors.forename: LeAnne H
authors.initials: LH
authors.lastname: Young
authors.affiliation: Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.
authors.forename: Vipul
authors.initials: V
authors.lastname: Periwal
mesh_terms: D000818:Animals; D049108:Cell Enlargement; D049109:Cell Proliferation; D015331:Cohort Studies; D004285:Dogs; D006498:Hepatectomy; D022781:Hepatocytes / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000502:physiology*; D008107:Liver Diseases / Q000601:surgery; D008115:Liver Regeneration / Q000502:physiology*; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D051379:Mice; D008962:Models, Theoretical; D011817:Rabbits; D051381:Rats