title: Expression of MTA2 and Ki-67 in hepatocellular carcinoma and their correlation with prognosis.
abstract: The aim of this study was to investigate the relationship among MTA2, Ki-67 and HCC patient prognosis. Tissue microarray and immunohistochemistry were used to detect the expression of MTA2 and Ki-67 in HCC samples and corresponding adjacent samples. We found MTA2 and Ki-67 were both increased in HCC tissues than those in adjacent tissues and nuclear MTA2 was associated with Ki-67 (P = 0.019). Moreover, nuclear MTA2 was a risk factor of distant metastasis in patients with HCC andKi-67 showed a negative correlation with histological grade (P < 0.05, P < 0.01, respectively). Multivariate Cox model analysis revealed that Ki-67 expression was an independent prognosis factor in HCC patients (P = 0.020). These results indicated there might be a tight correlation among MTA2, Ki-67 and HCC prognosis. MTA2 combined with Ki-67 might be used to predict HCC patient prognosis.
authors.affiliation: Department of General Surgery, Huashan Hospital, Fudan University Shanghai 200040, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.affiliation: Department of Gastroenterology, Tongji Hospital, Tongji University Shanghai 200065, China.
authors.forename: Jiangfeng
authors.initials: J
authors.lastname: Hu
authors.affiliation: National Engineering Center for Biochip at Shanghai Shanghai 201203, China.
authors.forename: Shizhang
authors.initials: S
authors.lastname: Zhu
authors.affiliation: National Engineering Center for Biochip at Shanghai Shanghai 201203, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Shen
authors.affiliation: National Engineering Center for Biochip at Shanghai Shanghai 201203, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Tongji Hospital, Tongji University Shanghai 200065, China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, Tongji Hospital, Tongji University Shanghai 200065, China ; National Engineering Center for Biochip at Shanghai Shanghai 201203, China.
authors.forename: Hengjun
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of General Surgery, Huashan Hospital, Fudan University Shanghai 200040, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D006655:Histone Deacetylases / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D019394:Ki-67 Antigen / Q000032:analysis / Q000096:biosynthesis*; D008113:Liver Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012097:Repressor Proteins / Q000032:analysis / Q000096:biosynthesis*; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D012097:Repressor Proteins; C120917:MTA2 protein, human; D006655:Histone Deacetylases
keywords: HCC; Ki-67; MTA2; liver cancer