title: Clinical Profile of Alcoholic Liver Disease in a Tertiary Care Centre and its Correlation with Type, Amount and Duration of Alcohol Consumption.
abstract: BACKGROUND
  Alcoholic liver disease (ALD) is a major cause of mortality and morbidity worldwide. Various studies show contradictory results about the role of amount, type and duration of alcohol exposure in determining the risk to develop ALD with ethnic variations in susceptibility to develop ALD and South Asians are shown to be more prone to develop ALD. This study was carried out to evaluate clinical profile of ALD in Indian population and to find out the correlation of disease severity and outcome with alcohol intake.
  
  
  METHODS
  201 patients of ALD were evaluated to correlate their clinical complications, biochemical parameters, prognostic markers (Discriminant function [DF] score, Model for end-stage liver disease [MELD] score and Child-Pugh score) and in-hospital mortality with their alcohol intake data in form of type, amount and duration of alcohol intake.
  
  
  RESULTS
  Hepatic encephalopathy, neutrophil to lymphocyte ratio (NLR) and all three prognostic scores showed a dose-dependent relation with the amount of alcohol intake (p < 0.05). However, the mortality rate didn't show a significant relation with amount. Further the type of alcohol intake didn't show any relation with disease severity; however, the duration of alcohol intake showed a positive relation with mortality rate. NLR emerged as a useful bedside marker of disease severity which correlates well with all prognostic markers (p < 0.05 for NLR's Spearman correlation with DF score and Child-Pugh Score), more so with MELD score (p < 0.0001); and complications like hepatic encephalopathy and hepato-renal syndrome. NLR also correlated with mortality rate but it was not statistically significant.
authors.forename: Nitya
authors.initials: N
authors.lastname: Nand
authors.forename: Parveen
authors.initials: P
authors.lastname: Malhotra
authors.forename: Dipesh Kumar
authors.initials: DK
authors.lastname: Dhoot
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D000434:Alcoholic Beverages; D044466:Asian People; D006801:Humans; D007194:India; D008108:Liver Diseases, Alcoholic / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012720:Severity of Illness Index; D062606:Tertiary Care Centers; D013997:Time Factors