title: Atheroprotective Properties of Serum IGF-1 in the Carotid and Coronary Territories and Beneficial Role on the Physical Fitness of the Oldest Old.
abstract: Our aim was to investigate whether physiological levels of soluble insulin-like growth factor-1 (IGF-1) associate with coronary and carotid atherosclerotic burden and physical fitness in the oldest old by means of a cross-sectional study including 100 community-dwelling individuals with no previous cardiovascular events. Linear correlation was found between IGF-1 and intima-media thickness, number of carotid plaques, and walking speed. Individuals in the upper IGF-1 tertile had smaller right and left intima-media thickness compared with the intermediate and lower tertiles, along with reduced atherosclerotic plaques. Also, walking speed was greater in the upper IGF-1 tertile. On the other hand, a nonlinear correlation was observed between IGF-1 and coronary calcification scores, with the intermediate IGF-1 tertile associated to the lowest scores of calcification and participants with lower circulating levels of IGF-1 showing higher frequency of high-risk morphology plaques. All in all, our report supports a territory-dependent, atherorefractory phenotype in the oldest old carrying middle and/or higher serum levels of IGF-1.
authors.affiliation: Gerontology Program and Physical Education Program, Catholic University of Brasília (UCB-DF), DF, Brazil.
authors.forename: Claudio
authors.initials: C
authors.lastname: Córdova
authors.affiliation: Physical Education Program, Catholic University of Brasília (UCB-DF), DF, Brazil.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Boullosa
authors.affiliation: Physical Education Program, Catholic University of Brasília (UCB-DF), DF, Brazil.
authors.forename: Misael R M
authors.initials: MR
authors.lastname: Custódio
authors.affiliation: Medical Faculty, State University of Campinas (UNICAMP), São Paulo, Brazil.
authors.forename: Luiz A
authors.initials: LA
authors.lastname: Quaglia
authors.affiliation: Medical Faculty, Universidade de Brasília (UnB), Federal District, Brazil.
authors.forename: Simone N
authors.initials: SN
authors.lastname: Santos
authors.affiliation: Medical Faculty, State University of Campinas (UNICAMP), São Paulo, Brazil.
authors.forename: Wladimir M
authors.initials: WM
authors.lastname: Freitas
authors.affiliation: Medical Faculty, State University of Campinas (UNICAMP), São Paulo, Brazil.
authors.forename: Andrei C
authors.initials: AC
authors.lastname: Sposito
authors.affiliation: Medical Faculty, Universidade de Brasília (UnB), Federal District, Brazil. nobrega@pq.cnpq.br.
authors.forename: Otávio T
authors.initials: OT
authors.lastname: Nóbrega
mesh_terms: D000369:Aged, 80 and over; D001938:Brazil; D002340:Carotid Artery Diseases / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D010641:Phenotype; D010809:Physical Fitness; D012307:Risk Factors; D000072797:Walking Speed
chemical_list: D007334:Insulin-Like Growth Factor I
keywords: Carotid atherosclerosis; Coronary calcification; Insulin-like growth factor-1; Physical fitness; Risk factor