title: Association of common variants of FTO in women with polycystic ovary syndrome.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is a common and complex multisystemic genetic disease. Previous genome-wide association study (GWAS) of PCOS has found several potentially causative single nucleotide polymorphisms (SNPs) in Han Chinese population. The goal of present investigation was to assess the potential association between rs1121980, rs1421085, rs1558902, rs8050136 SNPs and PCOS. In order to make a better elucidation of this disease, further investigations of association between SNPs susceptibility and PCOS become necessary.
  
  
  METHODS
  In the present study, we enrolled 212 patients with PCOS and 198 control subjects. Four polymorphisms of FTO gene (rs1121980, rs1421085, rs1558902, rs8050136) were genotyped by Taqman-MGB method, and their relationship with PCOS was speculated.
  
  
  RESULTS
  The allele frequency has no significant difference between the PCOS group and the controls. Genotype frequencies of the four SNPs in the additive, dominant and recessive models showed no significant difference between PCOS cases and controls.
  
  
  CONCLUSIONS
  Our results demonstrate that FTO gene has little association in PCOS development.
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Key Laboratory of Reproductive Medicine Jinan, China ; Department of Reproductive Medicine, Rizhao City Hospital of Traditional Chinese Medicine Rizhao, China ; National Research Center for Assisted Reproductive Technology and Reproductive Genetics Jinan, China ; The Key Laboratory for Reproductive Endocrinology of Ministry of Education Jinan, China.
authors.forename: Hongxi
authors.initials: H
authors.lastname: Xue
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Key Laboratory of Reproductive Medicine Jinan, China ; National Research Center for Assisted Reproductive Technology and Reproductive Genetics Jinan, China ; The Key Laboratory for Reproductive Endocrinology of Ministry of Education Jinan, China.
authors.forename: Han
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Key Laboratory of Reproductive Medicine Jinan, China ; National Research Center for Assisted Reproductive Technology and Reproductive Genetics Jinan, China ; The Key Laboratory for Reproductive Endocrinology of Ministry of Education Jinan, China.
authors.forename: Yueran
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Key Laboratory of Reproductive Medicine Jinan, China ; National Research Center for Assisted Reproductive Technology and Reproductive Genetics Jinan, China ; The Key Laboratory for Reproductive Endocrinology of Ministry of Education Jinan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Key Laboratory of Reproductive Medicine Jinan, China ; National Research Center for Assisted Reproductive Technology and Reproductive Genetics Jinan, China ; The Key Laboratory for Reproductive Endocrinology of Ministry of Education Jinan, China.
authors.forename: Zijiang
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Key Laboratory of Reproductive Medicine Jinan, China ; National Research Center for Assisted Reproductive Technology and Reproductive Genetics Jinan, China ; The Key Laboratory for Reproductive Endocrinology of Ministry of Education Jinan, China.
authors.forename: Jinlong
authors.initials: J
authors.lastname: Ma
mesh_terms: D000328:Adult; D000483:Alleles; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
keywords: FTO; genome-wide association study (GWAS); polycystic ovary syndrome (PCOS)