title: Stem cell transplantation in multiple myeloma and other plasma cell disorders (report from an EBMT preceptorship meeting).
abstract: The European Society for Blood and Marrow Transplantation Chronic Malignancies Working Party held a preceptorship meeting in Turin, Italy on 25-26 September 2014, to discuss the role of stem cell transplantation (SCT) in the treatment of multiple myeloma and other plasma cell disorders. Scientists and clinicians working in the field gathered to discuss a variety of topics including the results of recent clinical trials, basic research, the concept of minimal residual disease, and immune modulation. As individual presentations revealed, important advances have occurred in our understanding of the pathophysiology of myeloma and the role that SCT, along with other forms of immunotherapy, plays in treating it. Each presentation stimulated discussion and exchange of ideas among the attendants. We decided to summarize and, importantly, to update the meeting proceedings in this review to share stimulating discussions and ideas on potentially novel treatment strategies among clinicians.
authors.affiliation: a Division of Hematology , University of Torino , Torino , Italy ;|b Department of Molecular Biotechnology and Health Sciences , University of Torino , Torino , Italy ;
authors.forename: Benedetto
authors.initials: B
authors.lastname: Bruno
authors.affiliation: c Centre for Hematology, Imperial College London , London , UK ;
authors.forename: Holger W
authors.initials: HW
authors.lastname: Auner
authors.affiliation: d Department of Medicine , Karolinska Institutet , Stockholm , Sweden ;
authors.forename: Gösta
authors.initials: G
authors.lastname: Gahrton
authors.affiliation: e INSERM, UMR_S 938, Proliferation and Differentiation of Stem Cells , Paris , France ;
authors.forename: Laurent
authors.initials: L
authors.lastname: Garderet
authors.affiliation: a Division of Hematology , University of Torino , Torino , Italy ;|b Department of Molecular Biotechnology and Health Sciences , University of Torino , Torino , Italy ;
authors.forename: Moreno
authors.initials: M
authors.lastname: Festuccia
authors.affiliation: f Division of Hematology, Azienda Ospedaliera SS Antonio E Biagio E Cesare Arrigo , Alessandria , Italy ;
authors.forename: Marco
authors.initials: M
authors.lastname: Ladetto
authors.affiliation: g AOU IRCCS S. Martino-IST, Università Di Genova , Genova, Italy ;
authors.forename: Roberto M
authors.initials: RM
authors.lastname: Lemoli
authors.affiliation: h Division of Hematology and Cell Therapy, Ordine Mauriziano Hospital, Department of Molecular Biotechnology and Health Sciences , University of Torino , Torino , Italy ;
authors.forename: Massimo
authors.initials: M
authors.lastname: Massaia
authors.affiliation: i Centre for Cancer Research and Cell Biology , Queen's University of Belfast , Belfast , UK ;
authors.forename: Curly
authors.initials: C
authors.lastname: Morris
authors.affiliation: a Division of Hematology , University of Torino , Torino , Italy ;|b Department of Molecular Biotechnology and Health Sciences , University of Torino , Torino , Italy ;
authors.forename: Antonio
authors.initials: A
authors.lastname: Palumbo
authors.affiliation: j Medical Department V , Amyloidosis Center , Heidelberg , Germany ;
authors.forename: Stefan
authors.initials: S
authors.lastname: Schönland
authors.affiliation: a Division of Hematology , University of Torino , Torino , Italy ;|b Department of Molecular Biotechnology and Health Sciences , University of Torino , Torino , Italy ;
authors.forename: Mario
authors.initials: M
authors.lastname: Boccadoro
authors.affiliation: k Department of Stem Cell Transplantation , University Hospital Hamburg , Hamburg , Germany.
authors.forename: Nicolaus
authors.initials: N
authors.lastname: Kröger
mesh_terms: D000367:Age Factors; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002469:Cell Separation; D003131:Combined Modality Therapy; D060830:Consolidation Chemotherapy; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D060046:Maintenance Chemotherapy; D009101:Multiple Myeloma / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D018365:Neoplasm, Residual; D054219:Neoplasms, Plasma Cell / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D012008:Recurrence; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D016896:Treatment Outcome
keywords: Multiple myeloma; new drugs; stem cell transplantation