title: [Association between oral hygiene, chronic diseases, and oral squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the association between oral hygiene, chronic diseases, and oral squamous cell carcinoma.
  
  
  METHODS
  We performed a case-control study with 414 cases and 870 controls in Fujian during September 2010 to January 2015. Patients were newly diagnosed oral squamous cell carcinoma cases according to the pathologic diagnoses, control subjects were enrolled from community population. Epidemiological data were collected by in-person interviews using a standard questionnaire. The contents of the questionnaire included demography character, history of tobacco smoking and alcohol drinking, dietary habits, oral hygiene status, family history of cancer, etc. Using unconditional logistic regression analysis to estimate adjusted odds ratios (OR) and corresponding 95% confidence intervals (CI) for oral hygiene and chronic diseases. We also stratified by sex, smoking and drinking to explore possible difference in association between subgroups.
  
  
  RESULTS
  The multivariate logistic regression analysis indicated that number of teeth (20-27 and < 20), bad prosthesis, recurrent oral ulceration were the risk factors of oral squamous cell carcinoma, the adjusted OR (95% CI) values were 2.01 (1.49-2.73), 3.51 (2.39-5.15), 2.33 (1.79-3.04), 3.96 (2.11-7.44), respectively; brushing tooth once per bay, brushing tooth more than once per day, regular oral health examination at least 5 years per time were the protective factors of oral squamous cell carcinoma, the adjusted OR (95% CI) values were 0.24 (0.13-0.43), 0.13 (0.07-0.24), 0.37 (0.26-0.53), respectively. The stratification analysis indicated that recurrent oral ulceration could increase the risk of oral squamous cell carcinoma for non-smokers and non-drinking, the adjusted OR (95% CI) value was 5.21 (2.42-11.18) and 4.71 (2.37-9.36); and a risky effect of hypertension on risk of oral squamous cell carcinoma was observed for non-smokers and non-drinking, the adjusted OR (95% CI) values were 1.70 (1.10-2.61) and 1.58 (1.07-2.34).
  
  
  CONCLUSIONS
  Oral hygiene and chronic diseases could affect the incidence of oral squamous cell carcinoma.
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
authors.forename: Jiangfeng
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
authors.forename: Baochang
authors.initials: B
authors.lastname: He
authors.forename: Fa
authors.initials: F
authors.lastname: Chen
authors.forename: Fangping
authors.initials: F
authors.lastname: Liu
authors.forename: Lingjun
authors.initials: L
authors.lastname: Yan
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Hu
authors.forename: Lisong
authors.initials: L
authors.lastname: Lin
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.affiliation: Email: cailin_cn@ hotmail.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Cai
mesh_terms: D000428:Alcohol Drinking; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology*; D016022:Case-Control Studies; D002908:Chronic Disease / Q000453:epidemiology*; D004032:Diet; D006801:Humans; D015994:Incidence; D009062:Mouth Neoplasms / Q000453:epidemiology*; D016017:Odds Ratio; D009910:Oral Hygiene; D012307:Risk Factors; D012907:Smoking; D011795:Surveys and Questionnaires