title: The dual effect of paradoxical sleep deprivation on murine immune functions.
abstract: We aimed to evaluate the effect of paradoxical sleep deprivation on the cellular migration during inflammation, the peritoneal macrophage phenotype and the infectious stimulus outcomes. A/J mice were inoculated with thioglycollate and exposed to paradoxical sleep deprivation. Sleep-deprived animals presented decreased cell migration compared to controls. Nitric oxide production was reduced in macrophages from sleep-deprived mice compared to controls. Cell surface analysis showed that sleep deprivation reduced F4/80(+)/CD80(low) peritoneal cell population induced by thioglycollate injection. Sleep-deprived mice were not more susceptible to infection than control mice. Our findings challenge the general perception that sleep loss always increases infection susceptibility.
authors.affiliation: Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-900 São Paulo, Brazil. Electronic address: sanunes@usp.br.
authors.forename: Anderson
authors.initials: A
authors.lastname: Sá-Nunes
authors.affiliation: Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-900 São Paulo, Brazil.
authors.forename: Bruna
authors.initials: B
authors.lastname: Bizzarro
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, 04024-002 São Paulo, Brazil.
authors.forename: Flávia
authors.initials: F
authors.lastname: Egydio
authors.affiliation: Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-900 São Paulo, Brazil.
authors.forename: Michele S
authors.initials: MS
authors.lastname: Barros
authors.affiliation: Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, Brazil.
authors.forename: Renata
authors.initials: R
authors.lastname: Sesti-Costa
authors.affiliation: Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, 14040-903, Universidade de São Paulo, Ribeirão Preto, Brazil.
authors.forename: Elyara M
authors.initials: EM
authors.lastname: Soares
authors.affiliation: Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-900 São Paulo, Brazil.
authors.forename: Adriana
authors.initials: A
authors.lastname: Pina
authors.affiliation: Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-900 São Paulo, Brazil.
authors.forename: Momtchilo
authors.initials: M
authors.lastname: Russo
authors.affiliation: Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, 14040-903, Universidade de São Paulo, Ribeirão Preto, Brazil.
authors.forename: Lúcia H
authors.initials: LH
authors.lastname: Faccioli
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, 04024-002 São Paulo, Brazil.
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
authors.affiliation: Departamento de Psicobiologia, Universidade Federal de São Paulo, 04024-002 São Paulo, Brazil.
authors.forename: Monica L
authors.initials: ML
authors.lastname: Andersen
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D003345:Corticosterone / Q000097:blood / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000276:immunology* / Q000378:metabolism; D008297:Male; D051379:Mice; D012892:Sleep Deprivation / Q000097:blood / Q000276:immunology*
chemical_list: D003345:Corticosterone
keywords: Histoplasma capsulatum; Immune response; Inflammation; Macrophages; Sleep; Trypanosoma cruzi