title: Skeletally Diverse Synthesis of Indole-Fused Diazocine and Diazepine Frameworks by One-Pot, Two-Component Cascade Reaction.
abstract: An expeditious and novel strategy has been explored for the synthesis of structurally diverse indole-fused diazocine and diazepine derivatives. A substrate-based diversification approach of methyl-3-aminoindole/indoline benzoates coupled with the Pictet-Spengler reaction and three different reaction cascades furnished indolodiazepine and indoloquinoxalines. The formation of indolodiazocines proceeds through an initial condensation followed by intramolecular alkylation.
authors.affiliation: Department of Applied Chemistry, National Chiao-Tung University , 1001 Ta-Hseuh Road, Hsinchu 300-10, Taiwan.
authors.forename: Tushar Ulhas
authors.initials: TU
authors.lastname: Thikekar
authors.affiliation: Department of Applied Chemistry, National Chiao-Tung University , 1001 Ta-Hseuh Road, Hsinchu 300-10, Taiwan.
authors.forename: Manikandan
authors.initials: M
authors.lastname: Selvaraju
authors.affiliation: Department of Applied Chemistry, National Chiao-Tung University , 1001 Ta-Hseuh Road, Hsinchu 300-10, Taiwan.|Department of Medicinal and Applied Chemistry, Kaohsiung Medical University , 100 Shih-Chuan First Road, Kaohsiung 807-08, Taiwan.
authors.forename: Chung-Ming
authors.initials: CM
authors.lastname: Sun
mesh_terms: D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D001392:Azocines / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D001381:Azepines; D001392:Azocines; D007211:Indoles; C057812:indoline