title: The frequency of HLA alleles in the Romanian population.
abstract: Knowledge of human leukocyte antigen (HLA) allele frequencies is essential for bone marrow and kidney donor searches. The Romanian Caucasian population is heterogeneous and information on HLA polymorphism has not been well studied. We characterized the HLA genetic profile and allele frequencies of regional populations in Romania. HLA-A, B and DRB1 alleles were examined in 8252 individuals, belonging to the four main regions of Romania. The most common alleles found in the Romanian population are the following: HLA-A*01, A*02, A*03, A*11, A*24; HLA-B*18, B*35, B*44, B*51 and HLA-DRB1*01, DRB1*03, DRB1*07, DRB1*11, DRB1*13, DRB1*15, DRB1*16. More than half of the alleles are non-homogeneously spread in Romania. These results provide a starting point for future analyses of genetic heterogeneity in Romania.
authors.affiliation: Department of Transplant Immunology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. ileana.constantinescu@imunogenetica.ro.|Centre for Immunogenetics, Fundeni Clinical Institute, Bucharest, Romania. ileana.constantinescu@imunogenetica.ro.
authors.forename: Ileana
authors.initials: I
authors.lastname: Constantinescu
authors.affiliation: "Gheorghe Mihoc-Caius Iacob" Institute of Mathematical Statistics and Applied Mathematics, Bucharest, Romania.
authors.forename: Voicu
authors.initials: V
authors.lastname: Boșcaiu
authors.affiliation: Laboratory of Immunology and Genetics, "Sf. Spiridon" Hospital, Iasi, Romania.
authors.forename: Petru
authors.initials: P
authors.lastname: Cianga
authors.affiliation: Department of Transplant Immunology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.|Centre for Immunogenetics, Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Andrei-Antoniu
authors.initials: AA
authors.lastname: Dinu
authors.affiliation: Centre for Immunophysiology and Biotechnology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Elena
authors.initials: E
authors.lastname: Gai
authors.affiliation: Centre for Immunogenetics, Emergency Institute for Cardiovascular Diseases and Transplantation, Targu-Mures, Romania.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Melinte
authors.affiliation: Department of Transplant Immunology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.|Centre for Immunogenetics, Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Ana
authors.initials: A
authors.lastname: Moise
mesh_terms: D000483:Alleles; D016000:Cluster Analysis; D005787:Gene Frequency; D008040:Genetic Linkage; D005828:Genetics, Population; D005843:Geography; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis; D012383:Romania
chemical_list: D006680:HLA Antigens
keywords: Allele frequency; HLA polymorphism; Human leukocyte antigen (HLA); Population studies