title: Dietary intake variability in the cycle of cytotoxic chemotherapy.
abstract: This study was conducted to evaluate the dietary intake at different time points of the chemotherapeutic cycle.
  
  
  
  Fifty-five ovarian cancer patients receiving at least 2 cycles of chemotherapy were deemed eligible for this study, of which 41 participants completed the study. Anthropometrical measurements and Subjective Global Assessment were used to estimate nutritional status. The dietary intake was evaluated by 3-day food records: 3 days prior to, the day of, and the following day after chemotherapy.
  
  
  
  Mean energy intake was the lowest on the day of chemotherapy and the highest 3 days before treatment (mean difference, 413.8 kcal; p < 0.001). Similarly, some vitamins and macro- and micronutrients (K, Ca, vit D, folate, vit C) failed to reach 50 % of the recommended dietary allowances. When dividing patients into BMI categories, the energy intake per kilogram of body weight, in the normal-weight patients, was statistically higher than that in overweight and obese subjects (23.6 vs. 20.9 vs. 12.3 kcal, respectively; p = 0.0015). Similarly, the statistically significant differences were observed by the intake of fats (0.80 vs. 0.69 vs. 0.39 g, p = 0.0283) and carbohydrates (3.52 vs. 3.05 vs. 1.71 g, p = 0.0004).
  
  
  
  Dietary intake varies in the cycle of chemotherapy, with the lowest intake at the day of cytotoxic treatment and the highest before the next chemotherapy. Further studies evaluating dietary intake in patients undergoing chemotherapy should include in the protocol the exact time point of dietary assessment. The intake of energy, fats, and carbohydrates differs significantly across BMI categories.
authors.affiliation: Department of Human Nutrition and Hygiene, Poznan University of Life Science, Poznan, Poland.|Department of Oncology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Mardas
authors.affiliation: Department of Oncology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Radosław
authors.initials: R
authors.lastname: Mądry
authors.affiliation: Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany. stelmach@dife.de.|Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland. stelmach@dife.de.
authors.forename: Marta
authors.initials: M
authors.lastname: Stelmach-Mardas
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001835:Body Weight; D000077216:Carcinoma, Ovarian Epithelial; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D002149:Energy Intake; D005260:Female; D006801:Humans; D018977:Micronutrients / Q000008:administration & dosage; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D009752:Nutritional Status; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D018977:Micronutrients; D014815:Vitamins
keywords: Chemotherapy; Dietary intake; Energy; Epithelial ovarian cancer; Nutrients