title: Balance of synaptic and electrotonic connections controls the excitability of networks in biophysical model of epilepsy.
abstract: Recent studies have implicated astrocytes in multiple active roles in neuronal networks. In particular they have been shown to be able to moderate and alter neural firing patterns both in normal and epileptic conditions. In addition, it has been proposed that one of the roles of gap junctions between astrocytes, as well as neurons is in increasing synchronization of neuronal firing and potential epileptogenic effect. In this study we build upon a model of a network that incorporates both pyramidal cells and interneurons as well as astrocytes with potassium clearance mechanisms and basic calcium dynamics. We include electrotonic connections between cells to be able to separate the effects of synaptic connections and gap junctions on neuronal hyperexcitability. Preliminary findings of this model show that under normal conditions, when gap junctions are blocked the network exists in an interictal-like state. When the system is put in a zero calcium environment (i.e. synaptic connections are disabled), the network enters spontaneous rhythmic bursting with very regular spiking. This suggests that electrotonic connections play a crucial role in the epileptogenesis within the neuronal network.
authors.forename: Vasily
authors.initials: V
authors.lastname: Grigorovsky
authors.forename: Berj L
authors.initials: BL
authors.lastname: Bardakjian
mesh_terms: D001253:Astrocytes / Q000473:pathology / Q000502:physiology; D001703:Biophysics; D002118:Calcium / Q000378:metabolism; D004827:Epilepsy / Q000503:physiopathology*; D017629:Gap Junctions / Q000502:physiology; D006801:Humans; D007395:Interneurons / Q000473:pathology / Q000502:physiology; D008954:Models, Biological; D008959:Models, Neurological; D009415:Nerve Net; D009434:Neural Pathways / Q000502:physiology / Q000503:physiopathology*; D009474:Neurons / Q000473:pathology / Q000502:physiology; D011188:Potassium / Q000378:metabolism; D017966:Pyramidal Cells / Q000473:pathology / Q000502:physiology; D018091:Receptors, AMPA / Q000378:metabolism; D018079:Receptors, GABA / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism
chemical_list: D018091:Receptors, AMPA; D018079:Receptors, GABA; D016194:Receptors, N-Methyl-D-Aspartate; D011188:Potassium; D002118:Calcium