title: Antibacterial activity of diisocyanate-modified chitosan for biomedical applications.
abstract: A diisocyanate-modified chitosan (DIMC) was synthesized via a cross-linking reaction with chitosan and diphenyl methane diisocyanate. The structural and thermal properties of the DIMC were systematically characterized by FTIR, UV-vis, TGA, DSC, XRD and SEM. In addition, the optical properties were evaluated by photoluminescence. Finally, the antibacterial activities of the synthesized DIMC were examined against Escherichia coli and Staphylococcus pyogenes bacteria by agar plate diffusion method. The DIMC showed better degree of bacterial growth inhibition against E. coli as compared with unaltered chitosan. These results suggest that the synthesized chitosan xerogel could be used as a novel biodegradable material with improved antibacterial properties for biomedical applications.
authors.affiliation: Department of Chemistry, University of Coimbra, Coimbra 3004-535, Portugal. Electronic address: santoshics@gmail.com.
authors.forename: Santosh
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Biomedical Engineering, National University of Ireland, Galway, Ireland.
authors.forename: Vishwa
authors.initials: V
authors.lastname: Deepak
authors.affiliation: Department of Biotechnology, Vinoba Bhave University, Hazaribagh, Jharkhand, India.
authors.forename: Mridula
authors.initials: M
authors.lastname: Kumari
authors.affiliation: Department of Chemistry, MN National Institute of Technology, Allahabad 211004, India. Electronic address: pkd_437@yahoo.com.
authors.forename: P K
authors.initials: PK
authors.lastname: Dutta
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002152:Calorimetry, Differential Scanning; D048271:Chitosan / Q000737:chemistry*; D003485:Cyanates / Q000737:chemistry*; D052978:Disk Diffusion Antimicrobial Tests; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D003485:Cyanates; D048271:Chitosan
keywords: Antibacterial study; Characterization; Diisocyanate-modified chitosan