title: [Efficacy of Shugan Yiyang Capsules combined with sertraline on premature ejaculation].
abstract: OBJECTIVE
  To observe the clinical effect of Shugan Yiyang Capsules combined with sertraline in the treatment of premature ejaculation (PE).
  
  
  METHODS
  We randomly assigned 192 PE patients to receive sertraline hydrochloride 50 mg qd (control group, n = 96) or sertraline hydrochloride 50 mg qd plus Shugan Yiyang Capsules at the dose of 4 capsules tid ( combination therapy group, n = 96) , both for 6 weeks. We compared the intravaginal ejaculatory latency time (IELT) and Chinese Index of Premature Ejaculation ( CIPE) scores between the two groups of patients before and after medication and at 6 weeks after drug withdrawal.
  
  
  RESULTS
  Compared with the baseline, the IELT was significantly increased after 6 weeks of medication in the combination therapy group ([1.41 ± 0.53] vs [6.69 ± 3.56] min, P < 0.05) and the control group ([1.43 ± 0.48] vs [5.37 ± 2.91] min, P < 0.05), and so was the CIPE score in the former (9. 80 ± 2.06 vs 21.62 ± 4.76, P < 0.05) and the latter group ([9.41 ± 1.97] vs [20.85 ± 4.83] , P < 0.05). In comparison with the pre-medication indexes, the IELT ([3.77 ± 1.63] min) and CIPE score (16.92 ± 3.37) of the combined therapy group were remarkably improved at 6 weeks after drug withdrawal (P < 0.05), but not those of the control ([1.19 ± 1.34] min and 10.59 ± 2.38, P > 0.05).
  
  
  CONCLUSIONS
  Shugan Yiyang Capsules combined with sertraline have a definite and lasting effect on premature ejaculation.
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Wu
authors.forename: Yu-yan
authors.initials: YY
authors.lastname: Zeng
mesh_terms: D002214:Capsules; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D061686:Premature Ejaculation / Q000188:drug therapy*; D020280:Sertraline / Q000627:therapeutic use*
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; D020280:Sertraline