title: Treatment of metastatic head and neck cancer with mesenchymal stem cells combined with prodrug gene therapy.
abstract: This is a clinical observation of a patient treated for metastatic head and neck cancer with mesenchymal stem cells mediated prodrug gene therapy. The cells were applied intravenously. We did not observe any therapeutic effect. However, a temporal bicytopenia was observed.
authors.affiliation: Laboratory of Molecular Oncology, Cancer Research Institute, Slovak Academy of Sciences, Bratislava 83391, Slovakia.
authors.forename: J
authors.initials: J
authors.lastname: Lakota
authors.affiliation: Department of Medical Oncology, St. Elizabeth Cancer Institute, Bratislava 81250, Slovakia.
authors.forename: K
authors.initials: K
authors.lastname: Gocarova
authors.affiliation: Department of Medical Oncology, St. Elizabeth Cancer Institute, Bratislava 81250, Slovakia.
authors.forename: S
authors.initials: S
authors.lastname: Spanik
mesh_terms: D000328:Adult; D015316:Genetic Therapy / Q000379:methods; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000628:therapy*; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D009362:Neoplasm Metastasis / Q000188:drug therapy / Q000628:therapy; D011355:Prodrugs / Q000627:therapeutic use*
chemical_list: D011355:Prodrugs