title: Resting-state brain activity in the motor cortex reflects task-induced activity: A multi-voxel pattern analysis.
abstract: It has been suggested that resting-state brain activity reflects task-induced brain activity patterns. In this study, we examined whether neural representations of specific movements can be observed in the resting-state brain activity patterns of motor areas. First, we defined two regions of interest (ROIs) to examine brain activity associated with two different behavioral tasks. Using multi-voxel pattern analysis with regularized logistic regression, we designed a decoder to detect voxel-level neural representations corresponding to the tasks in each ROI. Next, we applied the decoder to resting-state brain activity. We found that the decoder discriminated resting-state neural activity with accuracy comparable to that associated with task-induced neural activity. The distribution of learned weighted parameters for each ROI was similar for resting-state and task-induced activities. Large weighted parameters were mainly located on conjunctive areas. Moreover, the accuracy of detection was higher than that for a decoder whose weights were randomly shuffled, indicating that the resting-state brain activity includes multi-voxel patterns similar to the neural representation for the tasks. Therefore, these results suggest that the neural representation of resting-state brain activity is more finely organized and more complex than conventionally considered.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Kusano
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kurashige
authors.forename: Isao
authors.initials: I
authors.lastname: Nambu
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Moriguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Hanakawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Wada
authors.forename: Rieko
authors.initials: R
authors.lastname: Osu
mesh_terms: D001931:Brain Mapping; D007858:Learning; D008279:Magnetic Resonance Imaging; D009044:Motor Cortex; D012146:Rest