title: Simplified fluid-structure coupled analysis of particle movement for designing of microfluidic cell sorter.
abstract: Recently, methods of the separation and selection of cells using a microfluidic device are receiving a lot of attention as the latest technology and those devices are called microfluidic cell sorter. Those methods have many advantages compared to conventional methods. There are a lot of researches on the microfluidic cell sorting but there isn't the automated design method of this device in spite of the necessary. To achieve the automated design of the microfluidic cell sorter, the analysis of the movement of cells in the microfluidic device and optimum design of the microfluidic cell sorter corresponding to kind of various cells are required. In the former case, the fluid-structure interaction analysis of fluid and cell movement is needed. However, it is very complex and needs a lot of computational time. Therefore, we focused on this problem in the fluid-structure interaction analysis for designing the microfluidic cell sorter. We assume cell is a sphere particle and propose the simplified fluid-structure coupled analysis which combines the CFD analysis with the motion equation of a sphere particle.
authors.forename: Yuto
authors.initials: Y
authors.lastname: Takagi
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kotev
authors.forename: Ken'ich
authors.initials: K
authors.lastname: Yano
mesh_terms: D002469:Cell Separation / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D005434:Flow Cytometry; D056656:Lab-On-A-Chip Devices; D044085:Microfluidics / Q000295:instrumentation* / Q000379:methods; D008962:Models, Theoretical