title: Laser speckle imaging of intra organ drug distribution.
abstract: Laminar flow in arteries causes streaming and uneven distribution of infused agents within the organ. This may lead to misinterpretation of experimental results and affect treatment outcomes. We monitor dynamical changes of superficial cortical blood flow in the rat kidney following different routes of administration of the vasoconstrictor angiotensin II. Our analysis reveals the appearance of large scale oscillations of the blood flow caused by inhomogeneous intra organ drug distribution.
authors.affiliation: Department of Biomedical Sciences, Copenhagen University, Blegdamsvej 3, 2200 Copenhagen N, Denmark.
authors.forename: Dmitry D
authors.initials: DD
authors.lastname: Postnov
authors.affiliation: Department of Biomedical Sciences, Copenhagen University, Blegdamsvej 3, 2200 Copenhagen N, Denmark.
authors.forename: Niels-Henrik
authors.initials: NH
authors.lastname: Holstein-Rathlou
authors.affiliation: Department of Biomedical Sciences, Copenhagen University, Blegdamsvej 3, 2200 Copenhagen N, Denmark.
authors.forename: Olga
authors.initials: O
authors.lastname: Sosnovtseva
keywords: (120.6150) Speckle imaging; (170.1470) Blood or tissue constituent monitoring; (170.5380) Physiology