title: Fetal programming and gestational diabetes mellitus.
abstract: Gestational diabetes mellitus is defined by new-onset glucose intolerance during pregnancy. About 2-5% of all pregnant women develop gestational diabetes during their pregnancies and the prevalence has increased considerably during the last decade. This metabolic condition is manifested when pancreatic β-cells lose their ability to compensate for increased insulin resistance during pregnancy, however, the pathogenesis of the disease remains largely unknown. Gestational diabetes is strongly associated with adverse pregnancy outcome as well as with long-term adverse effects on the offspring which likely occurs due to epigenetic modifications of the fetal genome. In the current review we address gestational diabetes and the short and long term complications for both mothers and offspring focusing on the importance of fetal programming in conferring risk of developing diseases in adulthood.
authors.affiliation: Department of Obstetrics & Gynecology, Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de Los Andes, Santiago, Chile.
authors.forename: Lara J
authors.initials: LJ
authors.lastname: Monteiro
authors.affiliation: Tommy's Centre for Fetal and Maternal Health, Medical Research Council Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Norman
authors.affiliation: Centre for Clinical Diagnostics, Faculty of Medicine and Biomedical Sciences, University of Queensland Centre for Clinical Research, Brisbane, QLD, Australia.
authors.forename: Gregory E
authors.initials: GE
authors.lastname: Rice
authors.affiliation: Department of Obstetrics & Gynecology, Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de Los Andes, Santiago, Chile; Centre for Clinical Diagnostics, Faculty of Medicine and Biomedical Sciences, University of Queensland Centre for Clinical Research, Brisbane, QLD, Australia. Electronic address: sillanes@uandes.cl.
authors.forename: Sebastián E
authors.initials: SE
authors.lastname: Illanes
mesh_terms: D016640:Diabetes, Gestational / Q000503:physiopathology*; D044127:Epigenesis, Genetic; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology*; D012307:Risk Factors
keywords: Epigenetics; Fetal programming; Gestational diabetes mellitus