title: Vascular Prostheses Based on Nanofibers from Aliphatic Copolyamide.
abstract: Tubular grafts based on nanofibers of copolymer of ε-caprolactam and hexamethylendiaminadipate were obtained by the electrospinning method. The strength of materials based on the dry nanofibers was 6.2 MPa with elongation at break of 133%, or 7.5 MPa and 299% in saline, respectively. The pressure value at which liquid started seeping through the tube wall was P = 10 kPa. Absence of cytotoxicity was proved, as well as adhesion and proliferation of mesenchymal stem cells on the surface. Tubes with inner diameter of 1 mm were tested in vivo in rat abdominal aorta. A layer of endothelial cells was shown to form on the inner side of the prosthesis after 30 days. There was no evidence of stenosis or dilatation of the prosthesis after 14 months with observation of endothelial and subendothelial layers.
authors.affiliation: Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint Petersburg, Russia.|Saint-Petersburg State Polytechnical University, Saint Petersburg, Russia.
authors.forename: P V
authors.initials: PV
authors.lastname: Popryadukhin
authors.affiliation: Saint-Petersburg State I.P. Pavlov Medical University, Saint Petersburg, Russia.
authors.forename: G I
authors.initials: GI
authors.lastname: Popov
authors.affiliation: Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint Petersburg, Russia. dobrov@hq.macro.ru.|Saint-Petersburg State Polytechnical University, Saint Petersburg, Russia. dobrov@hq.macro.ru.
authors.forename: I P
authors.initials: IP
authors.lastname: Dobrovolskaya
authors.affiliation: Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint Petersburg, Russia.|Saint-Petersburg State Polytechnical University, Saint Petersburg, Russia.
authors.forename: V E
authors.initials: VE
authors.lastname: Yudin
authors.affiliation: Saint-Petersburg State I.P. Pavlov Medical University, Saint Petersburg, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Vavilov
authors.affiliation: Saint-Petersburg State I.P. Pavlov Medical University, Saint Petersburg, Russia.
authors.forename: G Yu
authors.initials: GY
authors.lastname: Yukina
authors.affiliation: Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint Petersburg, Russia.|Saint-Petersburg State Polytechnical University, Saint Petersburg, Russia.
authors.forename: E M
authors.initials: EM
authors.lastname: Ivan'kova
authors.affiliation: Saint-Petersburg State Polytechnical University, Saint Petersburg, Russia.
authors.forename: I O
authors.initials: IO
authors.lastname: Lebedeva
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology / Q000601:surgery*; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D001807:Blood Vessel Prosthesis; D002209:Caprolactam / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D059630:Mesenchymal Stem Cells / Q000187:drug effects; D057139:Nanofibers / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D011474:Prosthesis Design; D051381:Rats
chemical_list: D001672:Biocompatible Materials; D002209:Caprolactam
keywords: Abdominal aorta; Aliphatic copolyamide; Endothelial cells; Nanofibers; Vascular prosthesis