title: Intravenous Ondansetron and the QT Interval in Adult Emergency Department Patients: An Observational Study.
abstract: OBJECTIVE
  Ondansetron is known to cause QT interval prolongation, but this effect and clinical significance has not been prospectively studied in adult emergency department (ED) patients. The primary objective was to determine the mean maximal corrected QT interval (QTc) prolongation after intravenous (IV) administration of 4 mg of ondansetron. The secondary objective was to report any serious adverse cardiac electrical events.
  
  
  METHODS
  This was a prospective, observational, single-center cohort study conducted between 2012 and 2013 in an academic, military hospital ED. Adult patients ordered to receive 4 mg of IV ondansetron were eligible for the study. A six-lead electrocardiogram was recorded at baseline and every 2 minutes after ondansetron administration for 20 minutes. The QTc was calculated using the Bazett formula. Serious adverse cardiac electrical events (nonsinus rhythm, severe bradycardia, and sudden cardiac death) were also recorded.
  
  
  RESULTS
  Twenty-two adult ED patients were enrolled. Ondansetron caused a mean prolongation of the QTc by 20 ms (95% confidence interval [CI] = 14 to 26 ms), with a mean proportion change from baseline of 5.2% (95% CI = 3.8% to 6.6%). There were zero (95% CI = 0 to 13%) reported serious adverse cardiac electrical events.
  
  
  CONCLUSIONS
  While QTc prolongation does occur in adult ED patients receiving IV ondansetron, the clinical impact is questionable.
authors.affiliation: Department of Emergency Medicine, Virginia Commonwealth University, Richmond, VA.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Moffett
authors.affiliation: Department of Emergency Medicine, Carl R. Darnall Army Medical Center, Fort Hood, TX.
authors.forename: Laquisha
authors.initials: L
authors.lastname: Cartwright
authors.affiliation: Department of Emergency Medicine, Blanchfield Army Community Hospital, Fort Campbell, KY.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Grossart
authors.affiliation: Department of Emergency Medicine, Carl R. Darnall Army Medical Center, Fort Hood, TX.
authors.forename: Dustin
authors.initials: D
authors.lastname: O'Keefe
authors.affiliation: Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, WA.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Kang
mesh_terms: D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000008:administration & dosage / Q000009:adverse effects*; D015331:Cohort Studies; D004562:Electrocardiography / Q000187:drug effects; D004636:Emergency Service, Hospital; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D017294:Ondansetron / Q000008:administration & dosage / Q000009:adverse effects*; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D000932:Antiemetics; D017294:Ondansetron