title: Effective Treatment of Pleural Epitheloid Hemangio-endothelioma with Pazopanib: A Case Report.
abstract: A patient with a pleural epitheloid hemangio-endothelioma (EHE) who failed to respond to six cycles of initial chemotherapy with iphosphamide and epirubicine was treated with pazopanib in second-line. A significant subjective and objective metabolic response on (18)F-fluoro-deoxyglucose positron-emission tomography-computed tomography was noted. Based on this observation, the role of vasculoendothelial growth factor receptor inhibitors such as pazopanib (or other tyrosine kinase inhibitors), in the treatment of pleural EHE should be established through prospective collaborative studies as upfront medication and in combination with chemotherapy.
authors.affiliation: Department of Medical Oncology, University Hospital Brussel, Brussels, Belgium denis.schallier@uzbrussel.be.
authors.forename: Denis
authors.initials: D
authors.lastname: Schallier
authors.affiliation: Department of Pulmonology OLV Aalst, Aalst, Belgium.
authors.forename: Berend-Jan
authors.initials: BJ
authors.lastname: Berendes
authors.affiliation: Department of Pathology, University Hospital Brussel, Brussels, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Lefesvre
authors.affiliation: Department of Nuclear Medicine University Hospital Brussel, Brussels, Belgium.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Everaert
mesh_terms: D000328:Adult; D018572:Disease-Free Survival; D006390:Hemangioendothelioma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007191:Indazoles; D008297:Male; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D012509:Sarcoma / Q000188:drug therapy* / Q000473:pathology; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007191:Indazoles; D011743:Pyrimidines; D013449:Sulfonamides; C516667:pazopanib
keywords: Epitheloid hemangio-endothelioma; case report; pazopanib; soft-tissue sarcoma