title: [Allelic variants of the CYP2D6: *4, *6 and *10 in a sample of resident from the Aragua state, Venezuela].
abstract: The aim of this study was to determine the CYP2D6: * 4, * 6 and * 10 gene variants frequency and to predict the metabolizer phenotype in a sample of 145 unrelated apparently healthy individuals residing in the state of Aragua, Venezuela. Genotypes were determined by Polymerase chain reaction assays followed by restriction endonucleases digestion. The metabolizer phenotype prediction was made based on the activity score system. The frequencies of CYP2D6 * 4, * 6 and * 10 allelic variants were 14.5%, 0.3% and 1%. A significant percentage of individuals were categorized as heterozygote-extensive/intermediate (23.5%) and poor metabolizers (4.1%), this information has potential clinical impact, because the CYP2D6 protein is involved in the metabolism of drugs frequently prescribed as: carvedilol, captopril, chloroquine, codeine, fluoxetine, fluvastatin, haloperidol, idarubicin, indinavir, imatinib, loperamide, nifedipine, ondansetron and tamoxifen.
authors.affiliation: Instituto de Investigaciones Biomédicas Dr. Francisco J. Triana Alonso (BIOMED), Facultad de Ciencias de la Salud, Universidad de Carabobo Sede Aragua, Maracay, Aragua, Venezuela.
authors.forename: Carlos
authors.initials: C
authors.lastname: Flores-Angulo
authors.affiliation: Instituto de Investigaciones Biomédicas Dr. Francisco J. Triana Alonso (BIOMED), Facultad de Ciencias de la Salud, Universidad de Carabobo Sede Aragua, Maracay, Aragua, Venezuela.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Villegas
authors.affiliation: Instituto de Investigaciones Biomédicas Dr. Francisco J. Triana Alonso (BIOMED), Facultad de Ciencias de la Salud, Universidad de Carabobo Sede Aragua, Maracay, Aragua, Venezuela.
authors.forename: Yuselin
authors.initials: Y
authors.lastname: Mora
authors.affiliation: Instituto de Investigaciones Biomédicas Dr. Francisco J. Triana Alonso (BIOMED), Facultad de Ciencias de la Salud, Universidad de Carabobo Sede Aragua, Maracay, Aragua, Venezuela.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Martínez
authors.affiliation: Instituto de Investigaciones Biomédicas Dr. Francisco J. Triana Alonso (BIOMED), Facultad de Ciencias de la Salud, Universidad de Carabobo Sede Aragua, Maracay, Aragua, Venezuela.
authors.forename: Teresa
authors.initials: T
authors.lastname: Oropeza
authors.affiliation: Instituto de Investigaciones Biomédicas Dr. Francisco J. Triana Alonso (BIOMED), Facultad de Ciencias de la Salud, Universidad de Carabobo Sede Aragua, Maracay, Aragua, Venezuela.
authors.forename: Nancy
authors.initials: N
authors.lastname: Moreno
mesh_terms: D000483:Alleles; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010641:Phenotype; D014687:Venezuela
chemical_list: D004364:Pharmaceutical Preparations; D019389:Cytochrome P-450 CYP2D6