title: Short- and long-term health consequences and current satisfaction levels for altruistic anonymous, identity-release and known oocyte donors.
abstract: OBJECTIVE
  What are the short- and long-term health consequences and current satisfaction of altruistic oocyte donors?
  
  
  CONCLUSIONS
  Donating oocytes in the majority (>90%) of donation cycles is not associated with harmful long-term general or reproductive health effects.
  
  
  BACKGROUND
  Knowledge of long-term health effects of oocyte donation on donors is sparse and follow-up studies have usually been carried out on commercial donors. Thus far, no major long-term harmful effects have been demonstrated. Most studies have reported a high level of donor satisfaction, but also less favorable experiences have been published.
  
  
  METHODS
  A retrospective cross-sectional survey of all women who had donated oocytes between 1990 and 2012 at three fertility clinics was carried out in spring 2013. A self-administered questionnaire was sent out to a total of 569 former oocyte donors.
  
  
  METHODS
  In all, 428 past donors answered the questionnaire assessing donor's demographic characteristics, short- and long-term medical and psychological experiences and satisfaction related to donations. Of the donors, 87% (371/428) were unknown and 13% (57/428) were known to the recipient. The mean follow-up time after the donation was 11.2 years (range from 0.5 to 23 years) and the mean age of the respondents was 42 years at the time of the study. To learn whether the demographic profile of donors was affected by the Finnish Assisted Reproduction Technology (ART) Act of 2007, we divided the 428 respondents into two groups: (i) women whose first donation took place between 1990 and 2007 (79% of the respondents) and (ii) women whose first donation took place between 2008 and 2012 (21% of the respondents). Before 2008, donors were non-identifiable (anonymous) but after 2008 persons born as a result of gamete donation could, from the age of 18, receive on request information identifying the donor.
  
  
  RESULTS
  The response rate was 75% (428/569). The mean age of the donors did not differ between the two time periods, but there was a higher proportion of donors in the youngest age group (20-24 years) and more childless donors (P < 0.05) after 2008 than between 1990 and 2007. Immediate complications occurred in 7.2% (42/582) of the donation cycles and the most common complication was ovarian hyperstimulation syndrome (OHSS) in 5.0% (29/582) of the treatments. There were no reports of ovarian or uterine cancer and only one case of breast cancer. After the donation, 11.5% of the donors experienced unsuccessful attempts to become pregnant. Almost all donors (99%) were satisfied or very satisfied with their decision to donate and 95% would warmly recommend it to other women. There were no differences between the known and unknown donors in this respect, or between the two time periods (before or after the ART Act in 2008). Four donors (1%) had regretted donation, and 7% would have wanted to have more support before and 14% after the donation.
  
  
  CONCLUSIONS
  Although the response rate was high, 25% of all former donors in the three participating clinics could not be included due to lack of response. The results are based on self-reported assessment of the experiences of former donors, and it is not possible to estimate the influence of recall bias.
  
  
  CONCLUSIONS
  To our knowledge, this is the largest study of health consequences and satisfaction levels on oocyte donors. Data from this study can be used to inform donor candidates about the medical aspects involved in the treatment and it provides information on how to support these women during and after the donation.
  
  
  BACKGROUND
  This study was supported by grants from the Medical Society Life and Health, and from the Otto A. Malm Foundation. There are no competing interests to report.
authors.affiliation: Väestöliitto (The Family Federation of Finland) Fertility Clinic, Olavinkatu 1 B, Helsinki, 00100 Helsinki, Finland viveca.soderstrom-anttila@vaestoliitto.fi.
authors.forename: Viveca
authors.initials: V
authors.lastname: Söderström-Anttila
authors.affiliation: Population Research Institute, Väestöliitto, 00100 Helsinki, Finland.
authors.forename: Anneli
authors.initials: A
authors.lastname: Miettinen
authors.affiliation: Population Research Institute, Väestöliitto, 00100 Helsinki, Finland.
authors.forename: Anna
authors.initials: A
authors.lastname: Rotkirch
authors.affiliation: Väestöliitto Fertility Clinic, Oulu, Finland.
authors.forename: Sinikka
authors.initials: S
authors.lastname: Nuojua-Huttunen
authors.affiliation: Väestöliitto Fertility Clinic, Turku, Finland.
authors.forename: Anna-Kaisa
authors.initials: AK
authors.lastname: Poranen
authors.affiliation: Väestöliitto (The Family Federation of Finland) Fertility Clinic, Olavinkatu 1 B, Helsinki, 00100 Helsinki, Finland.
authors.forename: Mari
authors.initials: M
authors.lastname: Sälevaara
authors.affiliation: Väestöliitto (The Family Federation of Finland) Fertility Clinic, Olavinkatu 1 B, Helsinki, 00100 Helsinki, Finland.
authors.forename: Anne-Maria
authors.initials: AM
authors.lastname: Suikkari
mesh_terms: D000328:Adult; D000533:Altruism; D003219:Confidentiality; D003430:Cross-Sectional Studies; D033001:Directed Tissue Donation; D005260:Female; D006801:Humans; D018587:Oocyte Donation / Q000009:adverse effects / Q000523:psychology*; D017060:Patient Satisfaction; D012189:Retrospective Studies; D013997:Time Factors
keywords: altruistic help; complication; long-term health; oocyte donor; satisfaction