title: A novel long noncoding RNA IRAIN regulates cell proliferation in non small cell lung cancer.
abstract: Long non-coding RNAs (lncRNAs) are a novel class of RNA molecules defined as transcripts longer than 200 nucleotides that lack protein coding potential. LncRNA IRAIN has been verified that it is related to acute myeloid leukemia (AML) and breast cancer. However, there was no study to clarify whether it is involved in non-small cell lung cancer (NSCLC). Here, we demonstrated IRAIN as a tumor promoter in NSCLC. Its expression level was remarkably upregulated in NSCLC tissues and connected with tumor size and smoking status. Knockdown of IRAIN suppressed NSCLC cells proliferation in vitro. These data identify IRAIN as a novel promoting gene, which plays a vital role in tumorigenesis of NSCLC.
authors.affiliation: Department of Oncology, First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
authors.affiliation: Department of Oncology, First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Biochemistry and Molecular Biology, Nanjing Medical University Nanjing, Jiangsu, China.
authors.forename: Er-Bao
authors.initials: EB
authors.lastname: Zhang
authors.affiliation: Department of Oncology, First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, China.
authors.forename: Xi-Yi
authors.initials: XY
authors.lastname: Lu
authors.affiliation: Department of Oncology, First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, China.
authors.forename: Shi-Dai
authors.initials: SD
authors.lastname: Jin
authors.affiliation: Department of Oncology, First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, China.
authors.forename: Ren-Hua
authors.initials: RH
authors.lastname: Guo
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding
keywords: A549; IRAIN; Long non-coding RNA; gene therapy; non-small cell lung cancer