title: Computer-aided diagnosis of plus disease in retinal fundus images of preterm infants via measurement of vessel tortuosity.
abstract: An increase in retinal vessel tortuosity can be indicative of the presence of various diseases including retinopathy of prematurity (ROP). Accurate detection and measurement of such changes could help in computer-aided diagnosis of plus disease, which warrants treatment of ROP. We present image processing methods for detection and segmentation of retinal vessels, quantification of vessel tortuosity, and diagnostic-decision-making criteria that incorporate the clinical definition of plus-diagnosis. The obtained results using 110 retinal fundus images of preterm infants (91 without plus and 19 with plus) provide high sensitivity = 0.89 (17/19) and excellent specificity = 0.95 (86/91) in the diagnosis of plus disease.
authors.forename: Faraz
authors.initials: F
authors.lastname: Oloumi
authors.forename: Rangaraj M
authors.initials: RM
authors.lastname: Rangayyan
authors.forename: Anna L
authors.initials: AL
authors.lastname: Ells
mesh_terms: D003936:Diagnosis, Computer-Assisted; D005654:Fundus Oculi; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D012171:Retinal Vessels; D012178:Retinopathy of Prematurity