title: Association of Lipopolysaccharide-Binding Protein With Aging-Related Adiposity Change and Prediabetes Among African Ancestry Men.
abstract: OBJECTIVE
  Cross-sectional studies suggest that lipopolysaccharide-binding protein (LBP) may be associated with obesity and metabolic disorders. However, prospective studies examining LBP are lacking. This prospective study investigated the association between LBP and metabolic abnormalities in 580 African ancestry men (mean age, 59.1 ± 10.5 years).
  
  
  METHODS
  We measured fasting serum LBP at baseline. Changes in adiposity and glucose homeostasis as well as case subjects with new type 2 diabetes and impaired fasting glucose (IFG) were assessed at a follow-up visit ~6 years later. Baseline LBP values were tested across quartiles for linear trend with metabolic measures. Multivariable logistic regression was used to determine the odds of new cases of IFG or diabetes per 1-SD greater baseline LBP.
  
  
  RESULTS
  LBP was significantly associated with baseline BMI, waist circumference, whole-body and trunk fat, skeletal muscle density, fasting serum insulin, and HOMA-insulin resistance (IR) (all P < 0.01). Greater baseline LBP was significantly associated with longitudinal increases in the percentage of trunk fat (P = 0.025) and HOMA-IR (P = 0.034), but only borderline so with a decrease in skeletal muscle density (P = 0.057). In men with normal glucose, baseline LBP was associated with increased odds of having IFG at follow-up after adjustment for age, baseline trunk fat, and lifestyle factors (odds ratio per 1-SD LBP: 1.51; 95% CI 1.02-2.21). This association was attenuated after additional adjustment for change in trunk fat (P = 0.067).
  
  
  CONCLUSIONS
  LBP may be a marker of prediabetes. Some of this association appears to be mediated through increased central and ectopic skeletal muscle adiposity.
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA cmt35@pitt.edu miljkovici@edc.pitt.edu.
authors.forename: Curtis M
authors.initials: CM
authors.lastname: Tilves
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Zmuda
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
authors.forename: Allison L
authors.initials: AL
authors.lastname: Kuipers
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
authors.forename: Cara S
authors.initials: CS
authors.lastname: Nestlerode
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
authors.forename: Rhobert W
authors.initials: RW
authors.lastname: Evans
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
authors.forename: Clareann H
authors.initials: CH
authors.lastname: Bunker
authors.affiliation: Tobago Health Studies Office, Scarborough, Tobago, Trinidad and Tobago, West Indies.
authors.forename: Alan L
authors.initials: AL
authors.lastname: Patrick
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA cmt35@pitt.edu miljkovici@edc.pitt.edu.
authors.forename: Iva
authors.initials: I
authors.lastname: Miljkovic
mesh_terms: D000209:Acute-Phase Proteins / Q000502:physiology; D050154:Adiposity / Q000502:physiology*; D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood / Q000502:physiology; D015415:Biomarkers / Q000097:blood; D044383:Black People; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D002352:Carrier Proteins / Q000097:blood* / Q000502:physiology; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood* / Q000502:physiology; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000503:physiopathology; D011236:Prediabetic State / Q000097:blood* / Q000503:physiopathology; D011446:Prospective Studies; D000099231:Lipopolysaccharide-Binding Protein
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D001786:Blood Glucose; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D000099231:Lipopolysaccharide-Binding Protein