title: The Effects of the Organic Flame-Retardant 1,2-Dibromo-4-(1,2-dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines.
abstract: The effects of the organic flame retardant 1,2-Dibromo-4-(1,2-dibromoethyl) cyclohexane (TBECH) on androgen receptor target gene expression were examined in the human LNCaP prostate cancer cell line. While γ-/δ-TBECH alone led to a significant increase in prostate-specific antigen (PSA) mRNA accumulation, both the α-/-TBECH and γ-/δ-TBECH mixtures repressed androgen-inducible PSA mRNA and protein accumulation in human LNCaP cells. Thus, we hypothesize that isomeric mixtures of TBECH may act as partial agonists of the androgen receptor.
authors.affiliation: Department of Biological Sciences, Simon Fraser University, Burnaby, B.C. V5A 1S6, Canada.
authors.forename: Lilian I L
authors.initials: LI
authors.lastname: Wong
authors.affiliation: Department of Biological Sciences, Simon Fraser University, Burnaby, B.C. V5A 1S6, Canada.
authors.forename: Alexandra R
authors.initials: AR
authors.lastname: Reers
authors.affiliation: Department of Biological Sciences, Simon Fraser University, Burnaby, B.C. V5A 1S6, Canada.
authors.forename: Heidi A
authors.initials: HA
authors.lastname: Currier
authors.affiliation: Department of Biological Sciences, Simon Fraser University, Burnaby, B.C. V5A 1S6, Canada.
authors.forename: Tony D
authors.initials: TD
authors.lastname: Williams
authors.affiliation: The Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, B.C. V6H 3Z6, Canada.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Cox
authors.affiliation: Pacific Wildlife Research Center, Environment Canada, Delta, B.C. V4K 3N2, Canada.
authors.forename: John E
authors.initials: JE
authors.lastname: Elliott
authors.affiliation: Faculty of Health Sciences, Simon Fraser University, Burnaby, B.C. V5A 1S6, Canada. tvb@sfu.ca.
authors.forename: Timothy V
authors.initials: TV
authors.lastname: Beischlag
mesh_terms: D045744:Cell Line, Tumor; D003510:Cyclohexanes / Q000494:pharmacology*; D052244:Endocrine Disruptors / Q000494:pharmacology*; D004785:Environmental Pollutants / Q000494:pharmacology*; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005411:Flame Retardants / Q000494:pharmacology*; D005786:Gene Expression Regulation; D006801:Humans; D007610:Kallikreins / Q000235:genetics / Q000378:metabolism; D008297:Male; D011467:Prostate / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D017430:Prostate-Specific Antigen / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011944:Receptors, Androgen / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects* / Q000235:genetics; D013237:Stereoisomerism
chemical_list: C410798:AR protein, human; D003510:Cyclohexanes; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D005411:Flame Retardants; D012333:RNA, Messenger; D011944:Receptors, Androgen; C517232:1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane; C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen
keywords: Androgen Receptor; Endocrine Disruptor; LNCaP; Organic Flame Retardant