title: Contemporary Strategies in the Prevention and Management of Fungal Infections.
abstract: Major patient groups at risk for invasive fungal infection are found in hematology, intensive care, and abdominal surgery units. The vast majority of invasive fungal infections are candidemia, pulmonary aspergillosis, and pulmonary or sinunasal mucormycosis, the latter typically in the context of diabetes. Clinical presentation is highly variable and depends on host, fungus, and organs involved. Symptoms are unspecific and, outside of fungemia, diagnosis is established by radiographic imaging combined with microbiological, serologic, and histopathological workup. Complex prevention and management strategies have been developed, and it is recommended to follow institutional pathways to standardize diagnostic and therapeutic strategies.
authors.affiliation: Department I of Internal Medicine, University Hospital of Cologne, Kerpener Str. 62, Cologne 50937, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Str. 26, Cologne 50931, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Koehler
authors.affiliation: Department I of Internal Medicine, University Hospital of Cologne, Kerpener Str. 62, Cologne 50937, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Str. 26, Cologne 50931, Germany; Clinical Trials Centre Cologne, ZKS Köln, Gleueler Str. 269, Cologne 50935, Germany; German Centre for Infection Research, Partner Site Bonn-Cologne, Kerpener Str. 62, Cologne 50937, Germany. Electronic address: oliver.cornely@uk-koeln.de.
authors.forename: Oliver A
authors.initials: OA
authors.lastname: Cornely
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D006801:Humans; D009181:Mycoses / Q000175:diagnosis / Q000382:microbiology / Q000517:prevention & control / Q000628:therapy*
chemical_list: D000935:Antifungal Agents
keywords: Empiric therapy; Invasive aspergillosis; Invasive candidiasis; Mucormycosis; Prophylaxis; Targeted therapy