title: Antigen Presentation of Vacuolated Apicomplexans--Two Gateways to a Vaccine Antigen.
abstract: For parasites that sequester themselves within a vacuole, new rules governing antigen presentation are coming into focus. Components of the host's autophagy machinery and the parasite's membranous nanotubular network within the parasitophorous vacuole play a major role in determining antigenicity of Toxoplasma proteins. As such, both parasite and vaccinologist may exploit these pathways to regulate the ever important CD8 T cell response to apicomplexan parasites.
authors.affiliation: School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA. Electronic address: kjensen5@ucmerced.edu.
authors.forename: Kirk D C
authors.initials: KDC
authors.lastname: Jensen
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D016782:Apicomplexa / Q000276:immunology*; D001343:Autophagy; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D016052:Protozoan Vaccines
chemical_list: D000941:Antigens; D016052:Protozoan Vaccines