title: Analysis of cellular signal transduction from an information theoretic approach.
abstract: Signal transduction processes the information of various cellular functions, including cell proliferation, differentiation, and death. The information for controlling cell fate is transmitted by concentrations of cellular signaling molecules. However, how much information is transmitted in signaling pathways has thus far not been investigated. Shannon's information theory paves the way to quantitatively analyze information transmission in signaling pathways. The theory has recently been applied to signal transduction, and mutual information of signal transduction has been determined to be a measure of information transmission. We review this work and provide an overview of how signal transduction transmits informational input and exerts biological output.
authors.affiliation: Division of Integrated Omics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: uda@bioreg.kyushu-u.ac.jp.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Uda
authors.affiliation: Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan; CREST, Japan Science and Technology Corporation, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: skuroda@bs.s.u-tokyo.ac.jp.
authors.forename: Shinya
authors.initials: S
authors.lastname: Kuroda
mesh_terms: D000465:Algorithms; D000818:Animals; D019295:Computational Biology; D019277:Entropy; D006801:Humans; D007257:Information Theory; D015398:Signal Transduction; D035501:Uncertainty
keywords: Cellular information transmission; Information theory; Mutual information; Signal transduction