title: Functional respiratory imaging (FRI) for optimizing therapy development and patient care.
abstract: Functional imaging techniques offer the possibility of improved visualization of anatomical structures such as; airways, lobe volumes and blood vessels. Computer-based flow simulations with a three-dimensional element add functionality to the images. By providing valuable detailed information about airway geometry, internal airflow distribution and inhalation profile, functional respiratory imaging can be of use routinely in the clinic. Three dimensional visualization allows for highly detailed follow-up in terms of disease progression or in assessing effects of interventions. Here, we explore the usefulness of functional respiratory imaging in different respiratory diseases. In patients with asthma and COPD, functional respiratory imaging has been used for phenotyping these patients, to predict the responder and non-responder phenotype and to evaluate different innovative therapeutic interventions.
authors.affiliation: a Department of Respiratory Medicine , University Hospital Antwerp , Edegem , Belgium.
authors.forename: Bita
authors.initials: B
authors.lastname: Hajian
authors.affiliation: b FLUIDDA nv , Kontich , Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: De Backer
authors.affiliation: b FLUIDDA nv , Kontich , Belgium.
authors.forename: Wim
authors.initials: W
authors.lastname: Vos
authors.affiliation: b FLUIDDA nv , Kontich , Belgium.
authors.forename: Cedric
authors.initials: C
authors.lastname: Van Holsbeke
authors.affiliation: a Department of Respiratory Medicine , University Hospital Antwerp , Edegem , Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: Clukers
authors.affiliation: a Department of Respiratory Medicine , University Hospital Antwerp , Edegem , Belgium.
authors.forename: Wilfried
authors.initials: W
authors.lastname: De Backer
mesh_terms: D000403:Airway Resistance; D001249:Asthma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000627:therapeutic use; D003198:Computer Simulation; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008168:Lung / Q000000981:diagnostic imaging*; D058988:Phosphodiesterase 4 Inhibitors / Q000627:therapeutic use; D011182:Postoperative Care; D057285:Precision Medicine; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D012119:Respiration; D014057:Tomography, X-Ray Computed
chemical_list: D001993:Bronchodilator Agents; D005938:Glucocorticoids; D058988:Phosphodiesterase 4 Inhibitors
keywords: COPD FRI; personalized treatment; phenotype