title: Association of ATP-binding cassette transporter A1 gene polymorphisms with plasma lipid variability and coronary heart disease risk.
abstract: OBJECTIVE
  Our study aimed to investigate the association of ABCA1 polymorphisms with plasma lipid variability and CHD risk in the Chinese Han population.
  
  
  METHODS
  754 CHD patients and 760 controls were included in this case-control study. Three SNPs (rs363717, rs4149339, and rs4149338) in ABCA1 3'UTR and one nonsynonymous SNP (rs2230808) in ABCA1 exon 35 were selected and genotyped. The analysis of genetic data was performed using the SNPstats program and the SPSS17.0 software.
  
  
  RESULTS
  Significant associations were observed between SNP rs363717 and CHD risk under different genetic models before or after Bonferroni corrections (codominant model: OR = 0.70, P = 0.003 for AG vs. AA; dominant model: OR = 0.71, P = 0.003 for GG + AG vs. AA). The nonsynonymous SNP rs2230808 was associated with higher total cholesterol levels (P = 0.047). The GCC haplotype (consisting of alleles of SNPs rs363717, rs4149339, and rs4149338) was associated with a decreased risk of CHD (OR = 0.8, P = 0.027). Three ABCA1 SNPs interacted with high triglyceride levels to increase CHD risk (P values of interactions were 0.010 for rs363717, 0.010 for rs4149339, and 0.020 for rs4149338, respectively).
  
  
  CONCLUSIONS
  Our results suggest that ABCA1 polymorphisms influence plasma lipid variability and CHD risk. ABCA1 polymorphisms could also modify the effects of plasma lipids on CHD risk.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University Changchun 130021, China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University Changchun 130021, China.
authors.forename: Yawen
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University Changchun 130021, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, VA Medical Center/116A2 950 Campbell Avenue, West Haven, CT 06516, USA.
authors.forename: Huiping
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University Changchun 130021, China.
authors.forename: Mingxi
authors.initials: M
authors.lastname: Yu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University Changchun 130021, China.
authors.forename: Joseph Sam
authors.initials: JS
authors.lastname: Kanu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University Changchun 130021, China.
authors.forename: Yichun
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University Changchun 130021, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University Changchun 130021, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhen
authors.affiliation: The Cardiovascular Center, The First Hospital of Jilin University Changchun 130021, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D064286:ATP Binding Cassette Transporter 1 / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1; D008055:Lipids
keywords: ATP-binding cassette transporter A1 gene; coronary heart disease; plasma lipids; single nucleotide polymorphism