title: Calibration and optimization of 3D digital breast tomosynthesis guided near infrared spectral tomography.
abstract: Calibration of a three-dimensional multimodal digital breast tomosynthesis (DBT) x-ray and non-fiber based near infrared spectral tomography (NIRST) system is challenging but essential for clinical studies. Phantom imaging results yielded linear contrast recovery of total hemoglobin (HbT) concentration for cylindrical inclusions of 15 mm, 10 mm and 7 mm with a 3.5% decrease in the HbT estimate for each 1 cm increase in inclusion depth. A clinical exam of a patient's breast containing both benign and malignant lesions was successfully imaged, with greater HbT was found in the malignancy relative to the benign abnormality and fibroglandular regions (11 μM vs. 9.5 μM). Tools developed improved imaging system characterization and optimization of signal quality, which will ultimately improve patient selection and subsequent clinical trial results.
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
authors.forename: Kelly E
authors.initials: KE
authors.lastname: Michaelsen
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
authors.forename: Venkataramanan
authors.initials: V
authors.lastname: Krishnaswamy
authors.affiliation: Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA ; Currently at School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
authors.forename: Linxi
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Vedantham
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA ; Currently at Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Steven P
authors.initials: SP
authors.lastname: Poplack
authors.affiliation: Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Karellas
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
authors.forename: Brian W
authors.initials: BW
authors.lastname: Pogue
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
authors.forename: Keith D
authors.initials: KD
authors.lastname: Paulsen
keywords: (120.3890) Medical optics instrumentation; (170.0110) Imaging systems; (170.3830) Mammography