title: Heat shock proteins and their association with major pediatric malignancies.
abstract: Heat shock proteins belong to a group of molecular chaperones responsible for the regulation of many intracellular processes. HSPs play a pivotal role in the survival of cells under stressful conditions. Over-expression of these proteins have been found in both healthy and a great number of cancer cells. HSPs may be involved in numerous carcinogenic and chemoresistant processes. Due to that fact, they may be referred to as diagnostic biomarkers of oncogenesis and potential targets for anticancer drugs. Thus, we decided to review the involvement of major HSPs in the most malignant childhood cancers.
authors.affiliation: Department of Medical Chemistry, Medical University of Gdansk, Gdansk 80-211, Debinki 1 Street, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Skora
authors.affiliation: Department of Medical Chemistry, Medical University of Gdansk, Gdansk 80-211, Debinki 1 Street, Poland, m.gorska@gumed.edu.pl.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Gorska
mesh_terms: D002648:Child; D006360:Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D011499:Protein Processing, Post-Translational
chemical_list: D006360:Heat-Shock Proteins