title: A chiral porous organic cage for molecular recognition using gas chromatography.
abstract: Molecular organic cages as shape-persistent organic molecules with permanent and accessible cavities have attracted a lot of interest because of their importance as host-guest systems. Herein, we report a chiral porous organic cage (POC) CC9 diluted with a polysiloxane OV-1701 to fabricate a CC9-coated capillary column, which was used for the high-resolution gas chromatographic separation of organic compounds, including positional isomers and racemates. On the CC9-coated capillary column, a large number of racemic compounds such as chiral alcohols, esters, ethers and epoxides can be resolved without derivatization. By comparing the chiral recognition ability of the CC9-coated column with the commercially available β-DEX 120 column and the POC CC3-R coated column recently reported by our group, the CC9-coated column offered good resolution during the separation of some racemates, that were not separated using the β-DEX 120 column or POC CC3-R coated column. Therefore, the CC9-coated column can be complementary to the β-DEX 120 column and CC3-R coated column. The results indicated that the CC9-coated column exhibited great potential for application in the separation of positional isomers and enantiomers with great selectivity, high resolution and good reproducibility.
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming 650500, PR China.
authors.forename: Sheng-Ming
authors.initials: SM
authors.lastname: Xie
authors.affiliation: Department of Chemistry, East China Normal University, Shanghai 200241, PR China.
authors.forename: Jun-Hui
authors.initials: JH
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming 650500, PR China.
authors.forename: Nan
authors.initials: N
authors.lastname: Fu
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming 650500, PR China.
authors.forename: Bang-Jin
authors.initials: BJ
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming 650500, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming 650500, PR China. Electronic address: yuan_limingpd@126.com.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Yuan
keywords: Capillary column; Chiral separation; Chiral stationary phase; Gas chromatography; Porous organic cage