title: Laparoscopic liver resection for hepatitis B and C virus-related hepatocellular carcinoma in patients with Child B or C cirrhosis.
abstract: BACKGROUND
  The aim of this study was to evaluate the clinical and oncological outcomes after laparoscopic liver resection (LLR) in patients with hepatitis B and C virus-related hepatocellular carcinoma (HCC) with Child B or C cirrhosis.
  
  
  METHODS
  Between January 2004 and December 2013, LLR was performed in 232 patients with HCC. Of these, 141 patients also had pathologically proven cirrhosis. Sixteen patients with hepatitis B and C virus-related HCC with Child B or C cirrhosis were included in the study. Thirteen (81.3%) patients had Child B disease and three (18.8%) patients had Child C disease.
  
  
  RESULTS
  The median operation time was 215 min, the median estimated blood loss was 350 mL, and the median hospital stay was eight days. Three patients (18.8%) experienced complications after surgery. There was no postoperative mortality or reoperation. The mean follow-up period was 51.6 months. HCC recurred in eight (50%) patients: seven intrahepatic recurrences and one extrahepatic recurrence. The treatments for recurrence were laparoscopic reoperation in one (6.3%) patient, trans-catheter arterial chemo-embolization (TACE) in one (6.3%) patient, radiofrequency ablation (RFA) in one (6.3%) patient, and combined TACE and RFA in four (25%) patients. The five-year postoperative overall survival (OS) and disease-free survival (DFS) were 84.4% and 41.7%, respectively.
  
  
  CONCLUSIONS
  This study demonstrates that LLR can be safely used in patients with hepatitis B and C virus-related HCC and Child B or C cirrhosis, with acceptable survival outcomes.
authors.affiliation: 1 Department of Hepatobiliary and Pancreatic Surgery, State Institution "Zaycev V.T. Institute of General and Urgent Surgery of National Academy of Medical Sciences of Ukraine", Ukraine ; 2 Department of General Surgery, Seoul National University Bundang Hospital, Seoul National University, Seoul, South Korea ; 3 Gastroenterology Surgical Centre, Department of Surgery, Mansoura University, Mansoura, Egypt.
authors.forename: Nataliya
authors.initials: N
authors.lastname: Brytska
authors.affiliation: 1 Department of Hepatobiliary and Pancreatic Surgery, State Institution "Zaycev V.T. Institute of General and Urgent Surgery of National Academy of Medical Sciences of Ukraine", Ukraine ; 2 Department of General Surgery, Seoul National University Bundang Hospital, Seoul National University, Seoul, South Korea ; 3 Gastroenterology Surgical Centre, Department of Surgery, Mansoura University, Mansoura, Egypt.
authors.forename: Ho-Seong
authors.initials: HS
authors.lastname: Han
authors.affiliation: 1 Department of Hepatobiliary and Pancreatic Surgery, State Institution "Zaycev V.T. Institute of General and Urgent Surgery of National Academy of Medical Sciences of Ukraine", Ukraine ; 2 Department of General Surgery, Seoul National University Bundang Hospital, Seoul National University, Seoul, South Korea ; 3 Gastroenterology Surgical Centre, Department of Surgery, Mansoura University, Mansoura, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Shehta
authors.affiliation: 1 Department of Hepatobiliary and Pancreatic Surgery, State Institution "Zaycev V.T. Institute of General and Urgent Surgery of National Academy of Medical Sciences of Ukraine", Ukraine ; 2 Department of General Surgery, Seoul National University Bundang Hospital, Seoul National University, Seoul, South Korea ; 3 Gastroenterology Surgical Centre, Department of Surgery, Mansoura University, Mansoura, Egypt.
authors.forename: Yoo-Seok
authors.initials: YS
authors.lastname: Yoon
authors.affiliation: 1 Department of Hepatobiliary and Pancreatic Surgery, State Institution "Zaycev V.T. Institute of General and Urgent Surgery of National Academy of Medical Sciences of Ukraine", Ukraine ; 2 Department of General Surgery, Seoul National University Bundang Hospital, Seoul National University, Seoul, South Korea ; 3 Gastroenterology Surgical Centre, Department of Surgery, Mansoura University, Mansoura, Egypt.
authors.forename: Jai Young
authors.initials: JY
authors.lastname: Cho
authors.affiliation: 1 Department of Hepatobiliary and Pancreatic Surgery, State Institution "Zaycev V.T. Institute of General and Urgent Surgery of National Academy of Medical Sciences of Ukraine", Ukraine ; 2 Department of General Surgery, Seoul National University Bundang Hospital, Seoul National University, Seoul, South Korea ; 3 Gastroenterology Surgical Centre, Department of Surgery, Mansoura University, Mansoura, Egypt.
authors.forename: YoungRok
authors.initials: Y
authors.lastname: Choi
keywords: Cirrhosis; hepatocellular carcinoma (HCC); laparoscopic liver resection (LLR); survival