title: Noninvasive evaluation of the correlation between regional cerebral blood flow and intraventricular brain temperature in temporal lobe epilepsy.
abstract: BACKGROUND
  In temporal lobe epilepsy (TLE), an uncoupling of cerebral blood flow (CBF) and metabolism is indicated. The aim of this study was to clarify this relationship by investigating intraventricular brain temperature (BT) and CBF in TLE using a noninvasive MRI technique.
  
  
  METHODS
  We recruited 38 subjects with left TLE and 39 subjects with right TLE. All patients underwent an MRI examination including diffusion-weighted imaging (DWI) and pseudo-continuous arterial spin labeling (pCASL). Intraventricular BT was calculated by a DWI thermometric technique, and regional CBF was obtained from pCASL images, and we analyzed the relationship between them using the statistical parametric mapping 8 software (SPM8).
  
  
  RESULTS
  In only the left TLE group, there was a significant negative correlation between CBF and BT in the left inferior frontal gyrus. Positive correlations in the bilateral posterior poles were also found at the trend level in left TLE group. The patients with right TLE showed no significant correlation.
  
  
  CONCLUSIONS
  Our results may reflect a regional uncoupling of blood flow and metabolism in those brain areas, and they may indicate that TLE has different metabolic regulation systems in the brain.
authors.affiliation: Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan; Department of Neuropsychiatry, Graduate School of Medicine, the University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo 113-8654, Japan.
authors.forename: Daichi
authors.initials: D
authors.lastname: Sone
authors.affiliation: Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Ota
authors.affiliation: Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan.
authors.forename: Kota
authors.initials: K
authors.lastname: Yokoyama
authors.affiliation: Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sumida
authors.affiliation: Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kimura
authors.affiliation: Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Etsuko
authors.initials: E
authors.lastname: Imabayashi
authors.affiliation: Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuda
authors.affiliation: Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan. Electronic address: snoriko@ncnp.go.jp.
authors.forename: Noriko
authors.initials: N
authors.lastname: Sato
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation; D038524:Diffusion Magnetic Resonance Imaging; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging*; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012984:Software; D013113:Spin Labels; D013696:Temperature; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology
chemical_list: D013113:Spin Labels
keywords: Arterial spin labeling; Diffusion-weighted imaging thermometry; Intraventricular brain temperature; Regional blood flow; Temporal lobe epilepsy