title: Post-Translational Modifications of Histones in Vertebrate Neurogenesis.
abstract: The process of neurogenesis, through which the entire nervous system of an organism is formed, has attracted immense scientific attention for decades. How can a single neural stem cell give rise to astrocytes, oligodendrocytes, and neurons? Furthermore, how is a neuron led to choose between the hundreds of different neuronal subtypes that the vertebrate CNS contains? Traditionally, niche signals and transcription factors have been on the spotlight. Recent research is increasingly demonstrating that the answer may partially lie in epigenetic regulation of gene expression. In this article, we comprehensively review the role of post-translational histone modifications in neurogenesis in both the embryonic and adult CNS.
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, University of Toronto Toronto, ON, Canada.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Mitrousis
authors.affiliation: Department of Cell and Systems Biology, Centre for the Analysis of Genome Evolution and Function, University of Toronto Toronto, ON, Canada.
authors.forename: Vincent
authors.initials: V
authors.lastname: Tropepe
authors.affiliation: Department of Neuroscience, Karolinska Institutet Stockholm, Sweden.
authors.forename: Ola
authors.initials: O
authors.lastname: Hermanson
keywords: chromatin; histone PTMs; histone acetylation; histone methylation; neural stem cell; neurogenesis