title: Clinicopathologic features of small cell glioblastomas.
abstract: Small cell glioblastoma (SCGBM) is a variant of glioblastomas characterized by a predominant population of small and monomorphic glial cells. The aim of the present study was to investigate clinical, neuroimaging, pathologic, and genetic features of SCGBM. The clinicopathologic and genetic features were evaluated in 14 patients with SCGBM. All cases were divided into multifocal and solitary type by MRI, and extent of microvascular proliferation, intratumoral necrosis, and perivascular lymphocytic accumulation were investigated. IDH1 mutations by immunohistochemistry (IDH1 R132H) and 1p 19q codeletion by fluorescence in situ hybridization were detected. Patients ranged from 23 to 92 years of age (median: 71 years), with three females and eleven males. The overall survival time of the patients ranged from 7 to 23 months (mean: 11 months). Nine patients (64%) were the multifocal type. Pathologic study revealed that the microvascular proliferation, necrosis, and lymphocytic infiltration were limited in SCGBM. Immunohistochemically, tumor cells were negative for IDH1 R132H in all patients. FISH analysis demonstrated that no SCGBM had 1p/19q codeletion in informative patients. Our investigation suggested that an elderly onset and multifocal lesions were characteristics of SCGBM associated with degradation of the immune response, infiltrative feature of tumor cells, and an unfavorable prognosis.
authors.affiliation: Department of Neurosurgery, University of Fukui, 23-3 Matsuoka-shimoaizuki, Eiheiji, Fukui, 910-1193, Japan. takeu@u-fukui.ac.jp.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takeuchi
authors.affiliation: Department of Neurosurgery, University of Fukui, 23-3 Matsuoka-shimoaizuki, Eiheiji, Fukui, 910-1193, Japan.
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Kitai
authors.affiliation: Department of Neurosurgery, University of Fukui, 23-3 Matsuoka-shimoaizuki, Eiheiji, Fukui, 910-1193, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hosoda
authors.affiliation: Department of Neurosurgery, University of Fukui, 23-3 Matsuoka-shimoaizuki, Eiheiji, Fukui, 910-1193, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Yamada
authors.affiliation: Department of Neurosurgery, University of Fukui, 23-3 Matsuoka-shimoaizuki, Eiheiji, Fukui, 910-1193, Japan.
authors.forename: Norichika
authors.initials: N
authors.lastname: Hashimoto
authors.affiliation: Department of Neurosurgery, University of Fukui, 23-3 Matsuoka-shimoaizuki, Eiheiji, Fukui, 910-1193, Japan.
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Kikuta
authors.affiliation: Department of Radiology, Tan-nan Regional Medical Center, 1-2-31, Sanroku-Cho, Sabae, Fukui, 916-8515, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Shimizu
authors.affiliation: Department of Radiology, Tan-nan Regional Medical Center, 1-2-31, Sanroku-Cho, Sabae, Fukui, 916-8515, Japan.|Department of Radiology, University of Fukui, 23-3 Matsuoka-shimoaizuki, Eiheiji, Fukui, 910-1193, Japan.
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Kimura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D017404:In Situ Hybridization, Fluorescence; D007521:Isocitrate Dehydrogenase / Q000235:genetics / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human
keywords: Immune response; MRI; Multifocal; Small cell glioblastoma