title: Monoclonal gammopathy: The good, the bad and the ugly.
abstract: Monoclonal gammopathy of undetermined significance (MGUS) is a condition characterized by the presence of a monoclonal gammopathy (MG) in which the clonal mass has not reached a predefined state in which the condition is considered malignant. It is a precursor to conditions such as multiple myeloma or lymphoma at a rate of ~1%/year. Thus, from a hematologic standpoint, MGUS is a fairly benign condition. However, it is now recognized that organ damage resulting from just the MG without the need MM or lymphoma can occur. One of the most recognized is nephropathy secondary to monoclonal gammopathy of renal significance (MGRS). Other well-recognized conditions include neuropathies, oculopathies and dermopathies. Some conditions such as autoimmune diseases and coagulopathies are less common and recognized. Finally, systemic involvement of multiple organs is well described in several entities. In all of these conditions, the role of the MG is no longer insignificant. Thus, the term MGUS should be avoided when describing these entities.
authors.affiliation: Department of Hematology, National University of Ireland, Galway, Ireland.
authors.forename: Siobhan V
authors.initials: SV
authors.lastname: Glavey
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address: leung.nelson@mayo.edu.
authors.forename: Nelson
authors.initials: N
authors.lastname: Leung
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D018450:Disease Progression; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D009101:Multiple Myeloma / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D010265:Paraproteinemias / Q000150:complications / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D011379:Prognosis; D012871:Skin Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D016896:Treatment Outcome
keywords: Amyloid; Infection; Monoclonal gammopathy of renal significance (MGRS); Monoclonal gammopathy of uncertain significance (MGUS); Renal