title: Immunosuppressant-Related Lower Eyelid Edema in Transplant Patients.
abstract: Solid organ transplantation is the preferred method of treatment for a number of advanced medical conditions, but it requires systemic immunosuppression to prevent transplant rejection. The authors report 2 unique cases of persistent eyelid edema following solid organ transplantation believed to be related to their systemic immunosuppression. The eyelid findings developed after initiation of the immunosuppressant sirolimus. In 1 patient, the eyelid edema has persisted despite discontinuation of the medication. In the second patient, the immunosuppression could not be altered; therefore, he underwent surgical excision of the edematous lower eyelid. Sirolimus associated eyelid edema is an important medication side effect for ophthalmic and eyelid specialists to consider when a patient with a history of organ transplantation presents with localized noninflamed eyelid edema. This edema can persist despite discontinuation of the medication. Surgical excision of the edematous eyelid can achieve good results.
authors.affiliation: Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, U.S.A.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Logan
authors.forename: Preeti J
authors.initials: PJ
authors.lastname: Thyparampil
authors.forename: Michael T
authors.initials: MT
authors.lastname: Yen
mesh_terms: D000328:Adult; D001706:Biopsy; D004487:Edema / Q000139:chemically induced* / Q000175:diagnosis; D005141:Eyelid Diseases / Q000139:chemically induced* / Q000175:diagnosis; D005143:Eyelids / Q000187:drug effects / Q000473:pathology; D006084:Graft Rejection / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D020123:Sirolimus / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus