title: Synthesis, lipophilicity and antimicrobial activity evaluation of some new thiazolyl-oxadiazolines.
abstract: OBJECTIVE
  Synthesis of new potential antimicrobial agents and evaluation of their lipophilicity.
  
  
  METHODS
  Ten new thiazolyl-oxadiazoline derivatives were synthesized and their structures were validated by 1H-NMR and mass spectrometry. The lipophilicity of the compounds was evaluated using the principal component analysis (PCA) method. The necessary data for applying this method were obtained by reverse-phase thin-layer chromatography (RP-TLC). The antimicrobial activities were tested in vitro against four bacterial strains and one fungal strain.
  
  
  RESULTS
  The lipophilicity varied with the structure but could not be correlated with the antimicrobial activity, since this was modest.
  
  
  CONCLUSIONS
  We have synthesized ten new heterocyclic compounds. After their physical and chemical characterization, we determined their lipophilicity and screened their antimicrobial activity.
authors.affiliation: Therapeutical Chemistry Department, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Cristina Ioana
authors.initials: CI
authors.lastname: Stoica
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Ioana
authors.initials: I
authors.lastname: IonuȚ
authors.affiliation: Molecular and Biomolecular Physics Department, National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca, Romania.
authors.forename: Adrian
authors.initials: A
authors.lastname: Pîrnău
authors.affiliation: Food Science and Technology Department, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania.
authors.forename: Carmen
authors.initials: C
authors.lastname: Pop
authors.affiliation: Food Science and Technology Department, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania.
authors.forename: AncuȚa
authors.initials: A
authors.lastname: Rotar
authors.affiliation: Pharmaceutical Technology and Biopharmaceutics Department, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Laurian
authors.initials: L
authors.lastname: Vlase
authors.affiliation: Therapeutical Chemistry Department, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Smaranda
authors.initials: S
authors.lastname: Oniga
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Oniga
keywords: Candida albicans; antibacterial; lipophilicity; thiazolyl-oxadiazoline