title: Absorption and excretion of Tetrabromobisphenol A in male Wistar rats following subchronic dermal exposure.
abstract: Tetrabromobisphenol A (TBBPA) is widely used as a flame retardant and frequently detected in environmental and biological samples. In this study, male Wistar rats were repeatedly exposed by dermal application to 20, 60, 200 and 600 mg TBBPA/kg body weight during 90 days. Concentrations of TBBPA in serum, urine and feces after dermal exposure were determined. TBBPA concentrations in serum ranged from 19.04 to 427.20 g/g lipids. The percentage of TBBPA dose recovered in serum on the 90th day varied from 0.002 ± 0.002% to 0.013 ± 0.008%, and the percentage of dose excreted in urine varied from 0.004 ± 0.002% to 0.072 ± 0.027%, while the percentage of dose recovered in feces were 3.30 ± 0.61% to 11.13 ± 3.16%. The results showed that about 3.31-11.21% TBBPA was absorbed dermally under different dosing regimens. TBBPA was excreted mainly in feces and small only amounts were recovered in urine.
authors.affiliation: State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China; Center for Environmental Health Research, South China Institute of Environmental Sciences, MEP, Guangzhou 510535, China. Electronic address: yuyunjiang@scies.org.
authors.forename: Yunjiang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China; Center for Environmental Health Research, South China Institute of Environmental Sciences, MEP, Guangzhou 510535, China.
authors.forename: Mingdeng
authors.initials: M
authors.lastname: Xiang
authors.affiliation: State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Ye
authors.affiliation: Institute of Environmental Health and Related Product Safety, China CDC, Beijing 100021, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Center for Environmental Health Research, South China Institute of Environmental Sciences, MEP, Guangzhou 510535, China.
authors.forename: Liangzhong
authors.initials: L
authors.lastname: Li
authors.affiliation: State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D005243:Feces / Q000737:chemistry*; D005411:Flame Retardants / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D011075:Polybrominated Biphenyls / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects*; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D004785:Environmental Pollutants; D005411:Flame Retardants; D011075:Polybrominated Biphenyls; C020806:tetrabromobisphenol A
keywords: Absorption; Dermal exposure; Tetrabromobisphenol A; Urinary and fecal excretion