title: Vitamin D Attenuates Left Atrial Volume Changes in African American Males with Obesity and Prediabetes.
abstract: Vitamin D deficiency is common among African Americans in the United States and is associated with increased cardiovascular disease risk. In this study, prediabetic African American males who were found to be vitamin D-deficient were randomized to vitamin D supplementation and assessed for changes in left atrial (LA) volume. Prediabetic African American males who were vitamin D-deficient (25(OH)D: 5.0-29 ng/mL) were randomized to high-dose ergocalciferol or placebo. Echocardiography was performed at baseline and at 1 year. Ejection fraction (EF), septal and posterior wall thickness, LA area, LA length, LA volume, E, A, septal and lateral e' and a', deceleration time, and isovolumetric relaxation time were collected. Eighty-one of 158 (51%) subjects received vitamin D2 . Baseline characteristics were similar among both groups. In the placebo group, left atrial volume significantly increased on follow-up (LA volume increased 6.3 mL, P = 0.0025). Compared with placebo group, the treatment group with ergocalciferol had attenuated increases in left atrial volume (LA volume increased 2.6 mL, P = 0.29). Changes in left atrial volume persisted when indexed to body surface area. There was no significant difference in other diastolic parameters and blood pressure between groups. In conclusion, vitamin D-deficient prediabetic African American males who were treated with high-dose vitamin D2 were found to have attenuated increases in left atrial volume compared with controls over 12-month follow-up.
authors.affiliation: Section of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.
authors.forename: Satish Jacob
authors.initials: SJ
authors.lastname: Chacko
authors.affiliation: Division of Cardiology, Department of Medicine, Advocate Christ Medical Center, Oak Lawn, Illinois.
authors.forename: Sunil
authors.initials: S
authors.lastname: Pauwaa
authors.affiliation: Section of Endocrinology, Department of Medicine, Jesse Brown VA Medical Center, Chicago, Illinois.|Division of Endocrinology and Metabolism, Department of Medicine, University of Illinois, Chicago, Illinois.
authors.forename: Elena
authors.initials: E
authors.lastname: Barengolts
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, University of Illinois, Chicago, Illinois.
authors.forename: Irina
authors.initials: I
authors.lastname: Ciubotaru
authors.affiliation: Section of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.|Division of Cardiology, Department of Medicine, Jesse Brown VA Medical Center, Chicago, Illinois.
authors.forename: Mayank M
authors.initials: MM
authors.lastname: Kansal
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D000368:Aged; D000369:Aged, 80 and over; D015984:Causality; D015897:Comorbidity; D019587:Dietary Supplements / Q000706:statistics & numerical data; D004452:Echocardiography / Q000706:statistics & numerical data; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000000981:diagnostic imaging / Q000208:ethnology*; D011236:Prediabetic State / Q000000981:diagnostic imaging / Q000208:ethnology*; D015995:Prevalence; D012307:Risk Factors; D016896:Treatment Outcome; D014481:United States; D014807:Vitamin D / Q000008:administration & dosage*; D014808:Vitamin D Deficiency / Q000000981:diagnostic imaging / Q000208:ethnology* / Q000517:prevention & control*
chemical_list: D014807:Vitamin D
keywords: diabetes; left atrium; supplementation; vitamin D