title: Fat suppression techniques for obtaining high resolution dynamic contrast enhanced bilateral breast MR images at 7T.
abstract: OBJECTIVE
  To compare water selective excitation (WSE) and Dixon fat suppression in the context of high-resolution dynamic contrast enhanced MRI of the breast at 7T.
  
  
  METHODS
  Ten healthy volunteers and one patient with a malignant breast lesion were scanned at 7T. The MRI protocol contained 3D T1-weighted gradient echo images obtained with both WSE fat suppression, multi echo Dixon fat suppression, and without fat suppression. Images were acquired at a (0.8mm)(3) or (0.7mm)(3) isotropic resolution with equal field of view and optimized such to obtain a maximal SNR. Image quality was scored qualitatively on overall image quality, sharpness of anatomical details, presence of artifacts, inhomogeneous fat suppression and the presence of water-fat shift. A quantitative scoring was obtained from the signal to noise ratio and contrast to noise ratio.
  
  
  RESULTS
  WSE scored significantly better in terms of overall image quality and the absence of artifacts. No significant difference in contrast to noise ratio was found between the two fat suppression methods.
  
  
  CONCLUSIONS
  When maximizing temporal and spatial resolution of high resolution DCE MRI of the breast, water selective excitation provides better image quality than multi echo Dixon at 7T.
authors.affiliation: University Medical Center Utrecht, Department of Radiology, Heidelberglaan 100, 3584CX, Utrecht, the Netherlands. Electronic address: T.A.vanderVelden@umcutrecht.nl.
authors.forename: Tijl A
authors.initials: TA
authors.lastname: van der Velden
authors.affiliation: University Medical Center Utrecht, Department of Radiology, Heidelberglaan 100, 3584CX, Utrecht, the Netherlands; University Medical Center Utrecht, Image Sciences Institute, Heidelberglaan 100, 3584CX, Utrecht, the Netherlands.
authors.forename: Alexander M Th
authors.initials: AM
authors.lastname: Schmitz
authors.affiliation: University Medical Center Utrecht, Department of Radiology, Heidelberglaan 100, 3584CX, Utrecht, the Netherlands; University Medical Center Utrecht, Image Sciences Institute, Heidelberglaan 100, 3584CX, Utrecht, the Netherlands.
authors.forename: Kenneth G A
authors.initials: KG
authors.lastname: Gilhuijs
authors.affiliation: University Medical Center Utrecht, Department of Radiology, Heidelberglaan 100, 3584CX, Utrecht, the Netherlands.
authors.forename: Wouter B
authors.initials: WB
authors.lastname: Veldhuis
authors.affiliation: University Medical Center Utrecht, Department of Radiology, Heidelberglaan 100, 3584CX, Utrecht, the Netherlands.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Luijten
authors.affiliation: Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Kettegaard Allé 30, DK-2650, Hvidovre, Denmark.
authors.forename: Vincent O
authors.initials: VO
authors.lastname: Boer
authors.affiliation: University Medical Center Utrecht, Department of Radiology, Heidelberglaan 100, 3584CX, Utrecht, the Netherlands.
authors.forename: Dennis W J
authors.initials: DW
authors.lastname: Klomp
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D000328:Adult; D016477:Artifacts; D001940:Breast / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging; D059629:Signal-To-Noise Ratio; D055815:Young Adult
chemical_list: D003287:Contrast Media
keywords: Breast; Cancer; Contrast sensitivity; Imaging; Magnetic resonance imaging