title: Meta-Analysis on the Correlation Between APOM rs805296 Polymorphism and Risk of Coronary Artery Disease.
abstract: BACKGROUND
  The present meta-analysis aimed to summarize the inconsistent findings on the association of apolipoprotein M gene (ApoM) rs805296 polymorphism with the risk of coronary artery disease (CAD), and to obtain a more authentic result about this topic.
  
  
  METHODS
  A total of 7 available articles were identified through electronic databases--PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI)--and their useful data were carefully extracted. The relationship between ApoM rs805296 polymorphism and CAD risk was assessed by odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs), which were calculated using the fixed- or random-effects model, according to the degree of heterogeneity. Hardy-Weinberg equilibrium test, sensitivity test, and publication bias examination were also performed in this meta-analysis.
  
  
  RESULTS
  According to the pooled results, ApoM rs805296 polymorphism conferred an increased risk of CAD under all the genetic contrasts: CC versus TT, CC + TC versus TT, CC versus TT+TC, C versus T, and TC versus TT (OR=2.13, 95% CI=1.16-3.91; OR=1.80, 95% CI=1.50-2.17; OR=1.91, 95% CI=1.04-3.51; OR=1.72, 95% CI=1.45-2.04; OR=1.78, 95% CI=1.47-2.15).
  
  
  CONCLUSIONS
  ApoM rs805296 polymorphism may be a risk factor for developing CAD.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of PLA General Hospital, Beijing, China (mainland).
authors.forename: HongYan
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of PLA General Hospital, Beijing, China (mainland).
authors.forename: Dong
authors.initials: D
authors.lastname: Shen
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of PLA General Hospital, Beijing, China (mainland).
authors.forename: ChunHong
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of PLA General Hospital, Beijing, China (mainland).
authors.forename: DangSheng
authors.initials: D
authors.lastname: Huang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of PLA General Hospital, Beijing, China (mainland).
authors.forename: YuMei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of PLA General Hospital, Beijing, China (mainland).
authors.forename: LiWei
authors.initials: L
authors.lastname: Zhang
mesh_terms: D001053:Apolipoproteins / Q000235:genetics*; D000075243:Apolipoproteins M; D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D054834:Lipocalins / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: C400523:APOM protein, human; D001053:Apolipoproteins; D000075243:Apolipoproteins M; D054834:Lipocalins; D014280:Triglycerides