title: High pressure assessment of bilayered electrospun vascular grafts by means of an Electroforce Biodynamic System®.
abstract: BACKGROUND
  Tissue engineering offers the possibility of developing a biological substitute material in vitro with the inherent properties required in vivo. However, the inadequate performance in vascular replacement of small diameter vascular grafts (VG) reduces considerably the current alternatives in this field. In this study, a bilayered tubular VG was produced, where its mechanical response was tested at high pressure ranges and compared to a native femoral artery.
  
  
  METHODS
  The VG was obtained using sequential electrospinning technique, by means of two blends of Poly(L-lactic acid) and segmented poly(ester urethane). Mechanical testing was performed in a biodynamic system and the pressure-strain relationship was used to determine the elastic modulus.
  
  
  RESULTS
  Elastic modulus assessed value of femoral artery at a high pressure range (33.02×106 dyn/cm(2)) was founded to be 36% the magnitude of VG modulus (91.47×106 dyn/cm(2)) at the same interval.
  
  
  CONCLUSIONS
  A new circulating mock in combination with scan laser micrometry have been employed for the mechanical evaluation of bioresorbable bilayered VGs. At same pressure levels, graft elasticity showed a purely "collagenic" behavior with respect to a femoral artery response.
authors.forename: Ricardo L
authors.initials: RL
authors.lastname: Armentano
authors.forename: Daniela
authors.initials: D
authors.lastname: Valdez Jasso
authors.forename: Leandro J
authors.initials: LJ
authors.lastname: Cymberknop
authors.forename: Florencia
authors.initials: F
authors.lastname: Montini Ballarin
authors.forename: Daniela
authors.initials: D
authors.lastname: Velez
authors.forename: Pablo C
authors.initials: PC
authors.lastname: Caracciolo
authors.forename: Gustavo
authors.initials: G
authors.lastname: Abraham
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D001807:Blood Vessel Prosthesis; D003094:Collagen; D055119:Elastic Modulus; D004548:Elasticity; D004867:Equipment Design; D005263:Femoral Artery / Q000637:transplantation; D019344:Lactic Acid / Q000737:chemistry; D008297:Male; D008422:Materials Testing / Q000295:instrumentation / Q000379:methods*; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry; D011312:Pressure; D034561:Sheep, Domestic; D023822:Tissue Engineering / Q000379:methods; D058017:Vascular Grafting / Q000295:instrumentation* / Q000379:methods
chemical_list: D011091:Polyesters; D011108:Polymers; D011140:Polyurethanes; C081821:microthane foam; D019344:Lactic Acid; C033616:poly(lactide); D003094:Collagen