title: The Effectiveness of Additional Treatment Modalities after the Failure of Recanalization by Thrombectomy Alone in Acute Vertebrobasilar Arterial Occlusion.
abstract: OBJECTIVE
  Acute vertebrobasilar artery occlusion (AVBAO) is a devastating disease with a high mortality rate. One of the most important factors affecting favorable clinical outcome is early recanalization. Mechanical thrombectomy is an emerging treatment strategy for achieving a high recanalization rates. However, thrombectomy alone can be insufficient to complete recanalization, especially for acute stroke involving large artery atheromatous disease. The purpose of this study is to investigate the safety and efficacy of mechanical thrombectomy in AVBAO.
  
  
  METHODS
  Fourteen consecutive patients with AVBAO were treated with mechanical thrombectomy. Additional multimodal treatments were intra-arterial (IA) thrombolysis, balloon angioplasty, or permanent stent placement. Recanalization by thrombectomy alone and multimodal treatments were assessed by the Thrombolysis in Cerebral Infarction (TICI) score. Clinical outcome was determined using the National Institutes of Health Stroke Scale (NIHSS) at 7 days and the modified Rankin Scale (mRS) at 3 months.
  
  
  RESULTS
  Thrombectomy alone and multimodal treatments were performed in 10 patients (71.4%) and 4 patients (28.6%), respectively. Successful recanalization (TICI 2b-3) was achieved in 11 (78.6%). Among these 11 patients, 3 (27.3%) underwent multimodal treatment due to underlying atherosclerotic stenosis. Ten (71.4%) of the 14 showed NIHSS score improvement of >10. Overall mortality was 3 (21.4%) of 14.
  
  
  CONCLUSIONS
  We suggest that mechanical thrombectomy is safe and effective for improving recanalization rates in AVBAO, with low complication rates. Also, in carefully selected patients after the failure of recanalization by thrombectomy alone, additional multimodal treatment such as IA thrombolysis, balloons, or stents can be needed to achieve successful recanalization.
authors.affiliation: Department of Neurosurgery, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Seong Mook
authors.initials: SM
authors.lastname: Kim
authors.affiliation: Department of Neurology, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Sung-Il
authors.initials: SI
authors.lastname: Sohn
authors.affiliation: Department of Neurology, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Jeong-Ho
authors.initials: JH
authors.lastname: Hong
authors.affiliation: Department of Interventional Neuroradiology, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Hyuk-Won
authors.initials: HW
authors.lastname: Chang
authors.affiliation: Department of Neurosurgery, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Chang-Young
authors.initials: CY
authors.lastname: Lee
authors.affiliation: Department of Neurosurgery, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Kim
keywords: Mechanical thrombectomy; Multimodal treatment; Vertebrobasilar artery occlusion