title: [PTTG1 enhances Hepatitis B Virus replication through P53].
abstract: OBJECTIVE
  To study the effect of pituitary tumor-transforming gene 1 (PTTG1) on Hepatitis B Virus (HBV) replication.
  
  
  METHODS
  The effect and mechanism of PTTG1 on HBV replication were examined by enzyme-linked immunosorbent assay (ELISA), immunoblot analysis, real-time PCR, dual-luciferase reporter assays and immunoblot analysis.
  
  
  RESULTS
  PTTG1 impairs the repression of P53 on HBV enhancer I and enhancer II through decreasing the protein level of P53, resulting in promotion of HBV replication.
  
  
  CONCLUSIONS
  PTTG1 enhances HBV replication through suppression of P53.
authors.forename: Shanxin
authors.initials: S
authors.lastname: Peng
authors.forename: Changfei
authors.initials: C
authors.lastname: Li
authors.forename: Lu
authors.initials: L
authors.lastname: Sun
authors.forename: Songdong
authors.initials: S
authors.lastname: Meng
mesh_terms: D056945:Hep G2 Cells; D006509:Hepatitis B / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D006515:Hepatitis B virus / Q000235:genetics / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D064249:Securin / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D064249:Securin; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C578002:pituitary tumor-transforming protein 1, human