title: The effect of dietary curcumin and capsaicin on hepatic fetuin-A expression and fat accumulation in rats fed on a high-fat diet.
abstract: Effects of curcumin (turmeric) and capsaicin (red pepper) on hepatic fat accumulation and fetuin-A expression in rats fed high-fat diet (HFD) is aimed to be investigated. Male Sprague-Dawley rats received HFD (60% of total calories from fat) and 0.15 g capsaicin/kg HFD and/or 1.5 g curcumin/kg HFD for 16 weeks. Hepatic AMPK, p-AMPK and fetuin-A expressions were determined by western blotting, liver lipid levels were measured with colorimetric methods and serum fetuin-A, insulin, leptin and adiponectin levels were detected using commercial ELISA kits. HFD increased hepatic lipid levels, fetuin-A expression and serum leptin, insülin and fetuin-A levels. Curcumin and capsaicin treatments significantly reduced hepatic fat accumulation and leptin levels; liver fetuin-A expression was decreased significantly by the curcumin treatment. Curcumin and capsaicin treatments attenuated hepatic fat accumulation and increased leptin levels related to inflammation. The suppression of hepatic fetuin-A expression is observed to be especially sensitive to curcumin.
authors.affiliation: a Department of Biochemistry , Istanbul Faculty of Medicine, Istanbul University , Çapa , Istanbul , Turkey .
authors.forename: Muhammed
authors.initials: M
authors.lastname: Seyithanoğlu
authors.affiliation: a Department of Biochemistry , Istanbul Faculty of Medicine, Istanbul University , Çapa , Istanbul , Turkey .
authors.forename: Yıldız
authors.initials: Y
authors.lastname: Öner-İyidoğan
authors.affiliation: a Department of Biochemistry , Istanbul Faculty of Medicine, Istanbul University , Çapa , Istanbul , Turkey .
authors.forename: Semra
authors.initials: S
authors.lastname: Doğru-Abbasoğlu
authors.affiliation: b Department of Biochemistry , and.
authors.forename: Sevda
authors.initials: S
authors.lastname: Tanrıkulu-Küçük
authors.affiliation: b Department of Biochemistry , and.
authors.forename: Hikmet
authors.initials: H
authors.lastname: Koçak
authors.affiliation: c Department of Medical Biology and Genetic , Faculty of Medicine, Istanbul Bilim University , Esentepe , Istanbul , Turkey.
authors.forename: Şule
authors.initials: Ş
authors.lastname: Beyhan-Özdaş
authors.affiliation: a Department of Biochemistry , Istanbul Faculty of Medicine, Istanbul University , Çapa , Istanbul , Turkey .
authors.forename: Necla
authors.initials: N
authors.lastname: Koçak-Toker
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002211:Capsaicin / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism; D003474:Curcumin / Q000494:pharmacology*; D059305:Diet, High-Fat / Q000009:adverse effects*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010750:Phosphoproteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000378:metabolism; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D010750:Phosphoproteins; D014280:Triglycerides; D060749:alpha-2-HS-Glycoprotein; D002784:Cholesterol; D055372:AMP-Activated Protein Kinases; D003474:Curcumin; D002211:Capsaicin
keywords: Fatty liver; fatty diet; red pepper; turmeric; α2 Heremans–Schmid glycoprotein