title: Molecular links between early energy metabolism alterations and Alzheimer's disease.
abstract: Recent studies suggest that the neurobiology of Alzheimer's disease (AD) pathology could not be explained solely by an increase in beta-amyloid levels. In fact, success with potential therapeutic drugs that inhibit the generation of beta amyloid has been low. Therefore, due to therapeutic failure in recent years, the scientists are looking for alternative hypotheses to explain the causes of the disease and the cognitive loss. Accordingly, alternative hypothesis propose a link between AD and peripheral metabolic alteration. Then, we review in depth changes related to insulin signalling and energy metabolism in the context of the APPSwe/PS1dE9 (APP/PS1) mice model of AD. We show an integrated view of the changes that occur in the early stages of the amyloidogenic process in the APP/PS1 double transgenic mice model. These early changes affect several key metabolic processes related to glucose uptake and insulin signalling, cellular energy homeostasis, mitochondrial biogenesis and increased Tau phosphorylation by kinase molecules like mTOR and Cdk5.
authors.affiliation: Unitats de Bioquimica i, i Ciencies de la Salut, Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, C./St. Llorenç 21 43201 Reus (Tarragona), Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Pedros
authors.affiliation: Unitats de Bioquimica i, i Ciencies de la Salut, Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, C./St. Llorenç 21 43201 Reus (Tarragona), Spain.
authors.forename: Ivan
authors.initials: I
authors.lastname: Patraca
authors.affiliation: Unitats de Bioquimica i, i Ciencies de la Salut, Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, C./St. Llorenç 21 43201 Reus (Tarragona), Spain.
authors.forename: Nohora
authors.initials: N
authors.lastname: Martinez
authors.affiliation: Unitat de Farmacologia i Farmacognosia Facultat de Farmacia, Institut de Biomedicina (IBUB), Centros de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat de Barcelona, Barcelona, Spain.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Petrov
authors.affiliation: Farmacologia, Facultat de Medicina i Ciencies de la Salut, Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, C./St. Llorenç 21 43201 Reus (Tarragona), Spain.
authors.forename: Francesc X
authors.initials: FX
authors.lastname: Sureda
authors.affiliation: Departament de Biologia Cellular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Carme
authors.initials: C
authors.lastname: Auladell
authors.affiliation: Departamento de Biologia Celular y Molecular, C.U.C.B.A., Universidad de Guadalajara and Division de Neurociencias, Centro de Investigacion Biomedica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Sierra Mojada 800, Col. Independencia.
authors.forename: Carlos
authors.initials: C
authors.lastname: Beas-Zarate
authors.affiliation: Unitats de Bioquimica i, Facultat de Medicina i Ciencies de la Salut, Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universitat Rovira i Virgili, C./ St. Llorenç 21 43201 Reus (Tarragona), Spain, jaume.folch@urv.cat.
authors.forename: Jaume
authors.initials: J
authors.lastname: Folch
mesh_terms: D054392:Adipokines / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D024821:Metabolic Syndrome / Q000378:metabolism*
chemical_list: D054392:Adipokines