title: Degradable Molybdenum Oxide Nanosheets with Rapid Clearance and Efficient Tumor Homing Capabilities as a Therapeutic Nanoplatform.
abstract: Molybdenum oxide (MoOx) nanosheets with high near-infrared (NIR) absorbance and pH-dependent oxidative degradation properties were synthesized, functionalized with polyethylene glycol (PEG), and then used as a degradable photothermal agent and drug carrier. The nanosheets, which are relatively stable under acidic pH, could be degraded at physiological pH. Therefore, MoOx-PEG distributed in organs upon intravenous injection would be rapidly degraded and excreted without apparent in vivo toxicity. MoOx-PEG shows efficient accumulation in tumors, the acidic pH of which then leads to longer tumor retention of those nanosheets. Along with the capability of acting as a photothermal agent for effective tumor ablation, MoOx-PEG can load therapeutic molecules with high efficiencies. This concept of inorganic theranostic nanoagent should be relatively stable in tumors to allow imaging and treatment, while being readily degradable in normal organs to enable rapid excretion and avoid long-term retention/toxicity.
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University Suzhou, Jiangsu, 215123, China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Song
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University Suzhou, Jiangsu, 215123, China.
authors.forename: Jiali
authors.initials: J
authors.lastname: Hao
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University Suzhou, Jiangsu, 215123, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liang
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University Suzhou, Jiangsu, 215123, China.
authors.forename: Teng
authors.initials: T
authors.lastname: Liu
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University Suzhou, Jiangsu, 215123, China.
authors.forename: Min
authors.initials: M
authors.lastname: Gao
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University Suzhou, Jiangsu, 215123, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.affiliation: College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China. hu.junqing@dhu.edu.cn.
authors.forename: Junqing
authors.initials: J
authors.lastname: Hu
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University Suzhou, Jiangsu, 215123, China. zliu@suda.edu.cn.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D004337:Drug Carriers / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D005260:Female; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008807:Mice, Inbred BALB C; D008982:Molybdenum / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D049329:Nanostructures / Q000008:administration & dosage* / Q000032:analysis*; D010087:Oxides / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000493:pharmacokinetics; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D004337:Drug Carriers; D010087:Oxides; D011092:Polyethylene Glycols; D008982:Molybdenum
keywords: antitumor agents; molybdenum oxide; nanosheets; photothermal therapy; rapid clearance