title: Effects of aripiprazole on the QTc: a case report.
abstract: The use of neuroleptics in the elderly has been a topic of debate since 2005 when the US Food and Drug Administration issued a black-box warning of increased risk of mortality in elderly patients with dementia-related psychosis. Antipsychotic alternatives such as divalproex are sometimes favored on an "off-label" basis to manage agitation in the demented elderly, and antipsychotic use is often clinically necessary to treat psychosis in older adults, with or without dementia. Concurrently, risk for iatrogenic corrected QT (QTc) prolongation on electrocardiogram (ECG) remains a concern with the use of many antipsychotic agents because of its associated potential for fatal arrhythmias.
authors.affiliation: 504 E 63rd St, Apt 25N, New York, NY 10065 karza@mskcc.org.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Karz
authors.forename: Daniel P
authors.initials: DP
authors.lastname: McGonigle
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Goldberg
authors.forename: Charles H
authors.initials: CH
authors.lastname: Kellner
authors.forename: Brandon S
authors.initials: BS
authors.lastname: Calenda
mesh_terms: D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000068180:Aripiprazole / Q000008:administration & dosage* / Q000009:adverse effects; D001714:Bipolar Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D014150:Antipsychotic Agents; D000068180:Aripiprazole