title: [Co-infection of hepatitis C virus among newly diagnosed HIV-infected adults in Taizhou prefecture of Zhejiang province, China].
abstract: OBJECTIVE
  To examine the prevalence and correlates of hepatitis C virus (HCV) co-infection as well as plasma HCV viral load among newly diagnosed HIV-infected adults during 2009-2012 in Taizhou prefecture of Zhejiang province, China.
  
  
  METHODS
  Five hundred and seventy-two adults who were newly diagnosed as HIV-infection were screened for anti-HCV immunoglobulin G (IgG). Plasma HCV RNA was quantified if positive for HCV IgG.
  
  
  RESULTS
  Forty-two (7.3%) out of the 572 HIV-infected adults were tested positive for HCV IgG. HCV infection was more likely to occur among participants who were infected with HIV through blood transmission (OR = 49.46, 95% CI: 13.71-178.48). Otherwise, HCV infection was less likely to occur among participants who were under 46-86 years of age (OR = 0.12, 95% CI: 0.02-0.58), those with mode of homosexual transmission of HIV (OR = 0.11, 95% CI: 0.01-0.86), with education of high school or above (OR = 0.13, 95% CI: 0.02-0.78). Thirty-three (78.6%) of the total 42 HIV-HCV patients with coinfection had detectable plasma HCV RNA, whereas 9 (21.4%) had undetectable plasma HCV RNA (i.e., lower than 5.0 × 10² IU/ml) or known as relative HCV viral suppression. No significant associations were noticed on factors as: HCV viral suppression and demographics, HIV transmission route and CD4⁺T-cell counts according to univariate regression analyses.
  
  
  CONCLUSIONS
  Prevalence of HCV co-infection was relatively high among newly diagnosed HIV-infected adults in this study area. Majority of the HIV-HCV coinfected patients had detectable plasma HCV RNA, of which the long term impact on disease progression deserves called for further research.
authors.affiliation: Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Taizhou Prefecture Center for Disease Control and Prevention, Zhejiang Province.
authors.forename: Qionghai
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Taizhou Prefecture Center for Disease Control and Prevention, Zhejiang Province.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Shen
authors.affiliation: Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China.
authors.forename: Meiyang
authors.initials: M
authors.lastname: Gao
authors.affiliation: Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China; Taizhou Prefecture Center for Disease Control and Prevention, Zhejiang Province; Email: linhaijiang @ hotmail.com.
authors.forename: Haijiang
authors.initials: H
authors.lastname: Lin
authors.affiliation: Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China; Email: nhe@shmu.edu.cn.
authors.forename: Na
authors.initials: N
authors.lastname: He
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D060085:Coinfection / Q000453:epidemiology*; D018450:Disease Progression; D015658:HIV Infections / Q000453:epidemiology*; D016174:Hepacivirus; D006508:Hepatitis Antibodies / Q000097:blood; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology*; D018937:Hepatitis C Antibodies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D015995:Prevalence; D012698:Serologic Tests; D019562:Viral Load
chemical_list: D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies; D007074:Immunoglobulin G