title: Long-Term Evaluation of MEK Inhibitor Retinal Toxicity With Multimodal Imaging.
abstract: MEK inhibitor chemotherapy, used in various malignancies, has been reported to be associated with serous retinal detachments. This study reports serial multimodal imaging focused primarily on infrared reflectance and spectral-domain optical coherence tomography (SD-OCT) in the monitoring of MEK inhibitor retinal toxicity. The benefit of OCT angiography in understanding the pathophysiology of MEK inhibitor toxicity is also shown.
authors.forename: Alan T
authors.initials: AT
authors.lastname: Sheyman
authors.forename: Fabio
authors.initials: F
authors.lastname: Scarinci
authors.forename: Amani A
authors.initials: AA
authors.lastname: Fawzi
authors.forename: Manjot K
authors.initials: MK
authors.lastname: Gill
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000633:toxicity*; D001562:Benzimidazoles / Q000008:administration & dosage; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D048369:MAP Kinase Kinase 1 / Q000037:antagonists & inhibitors*; D048370:MAP Kinase Kinase 2 / Q000037:antagonists & inhibitors*; D008875:Middle Aged; D064847:Multimodal Imaging; D061848:Optical Imaging; D010051:Ovarian Neoplasms / Q000188:drug therapy; D000081082:Phosphoinositide-3 Kinase Inhibitors; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D012163:Retinal Detachment / Q000139:chemically induced* / Q000175:diagnosis; D013844:Thiazoles / Q000008:administration & dosage; D041623:Tomography, Optical Coherence
chemical_list: D001562:Benzimidazoles; D000081082:Phosphoinositide-3 Kinase Inhibitors; D013844:Thiazoles; C585539:Alpelisib; C581313:binimetinib; D048369:MAP Kinase Kinase 1; D048370:MAP Kinase Kinase 2