title: Endobronchial ultrasound-guided transbronchial needle aspiration is useful as an initial procedure for the diagnosis of lymphoma.
abstract: BACKGROUND
  The usefulness of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for evaluating hilar, mediastinal and central parenchymal lesions has been well established. However, its utility for diagnosing lymphoma is controversial. The aim of this study was to evaluate the diagnostic utility of EBUS-TBNA for the definitive diagnosis of de novo lymphoma with subtype classification.
  
  
  METHODS
  Patients with lymphoma who underwent EBUS-TBNA for diagnostic purposes at a single institution between March 2004 and May 2013 were retrospectively reviewed.
  
  
  RESULTS
  Of the 971 patients who underwent EBUS-TBNA during the study period, 19 patients, who did not have a previous history of lymphoma, had a final diagnosis of lymphoma. EBUS-TBNA provided a diagnosis accompanied with subtype classification in 6 patients (32%), a suspicious but not definitive classification in 10 patients (53%), and a negative classification in 3 patients (16%). Immunohistochemical staining for definitive diagnosis was performed in 15 of 16 patients (94%), with suspicious results from routine hematoxylin and eosin staining. No procedure-related complications occurred.
  
  
  CONCLUSIONS
  EBUS-TBNA is a useful initial diagnostic procedure, aiding decisions for the management of patients with suspected lymphoma, even though the sensitivity of EBUS-TBNA for diagnosing lymphoma with subtype classification was lower than previously reported.
authors.affiliation: Department of Respiratory Medicine, Nagoya Medical Center, Nagoya, Japan; Respiratory Unit, Department of Medicine, Rajavithi Hospital, Bangkok, Thailand. Electronic address: potjanee_krr@yahoo.com.
authors.forename: Potjanee
authors.initials: P
authors.lastname: Korrungruang
authors.affiliation: Department of Respiratory Medicine, Nagoya Medical Center, Nagoya, Japan. Electronic address: masahideo@aol.com.
authors.forename: Masahide
authors.initials: M
authors.lastname: Oki
authors.affiliation: Department of Respiratory Medicine, Nagoya Medical Center, Nagoya, Japan. Electronic address: saka@med.nagoya-u.ac.jp.
authors.forename: Hideo
authors.initials: H
authors.lastname: Saka
authors.affiliation: Department of Respiratory Medicine, Nagoya Medical Center, Nagoya, Japan. Electronic address: yo-kogure@umin.ac.jp.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Kogure
authors.affiliation: Department of Respiratory Medicine, Nagoya Medical Center, Nagoya, Japan. Electronic address: riems215@hotmail.com.
authors.forename: Rie
authors.initials: R
authors.lastname: Tsuboi
authors.affiliation: Department of Respiratory Medicine, Nagoya Medical Center, Nagoya, Japan. Electronic address: saorioka.a@gmail.com.
authors.forename: Saori
authors.initials: S
authors.lastname: Oka
authors.affiliation: Department of Respiratory Medicine, Nagoya Medical Center, Nagoya, Japan. Electronic address: nakahtms1231@gmail.com.
authors.forename: Masashi
authors.initials: M
authors.lastname: Nakahata
authors.affiliation: Department of Respiratory Medicine, Nagoya Medical Center, Nagoya, Japan. Electronic address: flavored_coffee10@yahoo.co.jp.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Hori
authors.affiliation: Department of Respiratory Medicine, Nagoya Medical Center, Nagoya, Japan. Electronic address: konyasu222@gmail.com.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Murakami
authors.affiliation: Department of Respiratory Medicine, Nagoya Medical Center, Nagoya, Japan. Electronic address: yuko0525ise@hotmail.co.jp.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ise
authors.affiliation: Department of Respiratory Medicine, Nagoya Medical Center, Nagoya, Japan. Electronic address: drshaimaa76@gmail.com.
authors.forename: Shimaa Nour Moursi
authors.initials: SN
authors.lastname: Ahmed
authors.affiliation: Department of Respiratory Medicine, Nagoya Medical Center, Nagoya, Japan. Electronic address: kitagawc@nnh.hosp.go.jp.
authors.forename: Chiyoe
authors.initials: C
authors.lastname: Kitagawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle / Q000379:methods*; D001980:Bronchi / Q000473:pathology*; D005260:Female; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods*; D008223:Lymphoma / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D008875:Middle Aged; D012189:Retrospective Studies; D014463:Ultrasonography; D055815:Young Adult
keywords: Bronchoscopy; Endobronchial ultrasound-guided transbronchial needle aspiration; Lymphadenopathy; Lymphoma; Mediastinum