title: Differences in morphological features and minimum apparent diffusion coefficient values among breast cancer subtypes using 3-tesla MRI.
abstract: OBJECTIVE
  To compare the morphology and minimum apparent diffusion coefficient (ADC) values among breast cancer subtypes.
  
  
  METHODS
  Ninety-three patients, who underwent breast MRI and collectively had 98 pathologically proven invasive carcinomas, were enrolled. Morphology was evaluated according to BIRADS-MRI. Minimum ADC was measured. Morphology and minimum ADC were compared among subtypes. Multivariate logistic regression analyses were used to identify the characteristics associated with different subtypes.
  
  
  RESULTS
  Oval/round shape was significantly associated with triple-negative (TN) cancer (TN vs. non-TN: 90.9% vs. 45.2%; p=0.0123). Rim enhancement was significantly less frequent in Luminal A (Luminal A vs. non-Luminal A: 34.2% vs. 76.1%; p=0.0003). The minimum ADC of Luminal A was significantly higher than that of Luminal B (HER2-negative) (834 vs. 748×10(-6)mm(2)/s; p<0.025). The minimum ADC of the TN-special type was significantly higher than that of TN-ductal (997 vs. 702×10(-6)mm(2)/s; p<0.025). On the multivariate analysis comparing the characteristics associated with Luminal A vs. Luminal B (HER2-negative), the internal enhancement characteristics of the mass and minimum ADC were significant factors.
  
  
  CONCLUSIONS
  Morphology and minimum ADC would be useful in distinguishing breast cancer subtypes.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, N14, W5, Kita-ku, Sapporo 060-8648, Japan. Electronic address: fumikato@med.hokudai.ac.jp.
authors.forename: Fumi
authors.initials: F
authors.lastname: Kato
authors.affiliation: Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, N14, W5, Kita-ku, Sapporo 060-8648, Japan. Electronic address: kkudo@huhp.hokudai.ac.jp.
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Kudo
authors.affiliation: Department of Breast Surgery, Hokkaido University Hospital, N14, W5, Kita-ku, Sapporo 060-8648, Japan. Electronic address: hirokoy@huhp.hokudai.ac.jp.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Yamashita
authors.affiliation: Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, N15, W7, Kita-ku, Sapporo 060-8638, Japan. Electronic address: jeff.wang@pop.med.hokudai.ac.jp.
authors.forename: Jeff
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Breast Surgery, Hokkaido University Hospital, N14, W5, Kita-ku, Sapporo 060-8648, Japan. Electronic address: hosodam@seagreen.ocn.ne.jp.
authors.forename: Mitsuchika
authors.initials: M
authors.lastname: Hosoda
authors.affiliation: Department of Surgical Pathology, Hokkaido University Hospital, N14, W5, Kita-ku, Sapporo 060-8648, Japan. Electronic address: kyanack@huhp.hokudai.ac.jp.
authors.forename: Kanako C
authors.initials: KC
authors.lastname: Hatanaka
authors.affiliation: Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, N14, W5, Kita-ku, Sapporo 060-8648, Japan. Electronic address: r_mimufam@huhp.hokudai.ac.jp.
authors.forename: Rie
authors.initials: R
authors.lastname: Mimura
authors.affiliation: Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, N14, W5, Kita-ku, Sapporo 060-8648, Japan. Electronic address: norikooyama@med.hokudai.ac.jp.
authors.forename: Noriko
authors.initials: N
authors.lastname: Oyama-Manabe
authors.affiliation: Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, N15, W7, Kita-ku, Sapporo 060-8638, Japan. Electronic address: shirato@med.hokudai.ac.jp.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shirato
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000097:blood / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000097:blood / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000097:blood*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen
keywords: Breast cancer subtypes; Diffusion weighed imaging; Ki-67; Magnetic resonance imaging