title: Sudden Development of Thrombocytopenia After Reversal of Anticoagulation for Surgery.
abstract: Herein, we report a case of post-transfusion purpura after the reversal of anticoagulation for surgical purposes in a 66-year old ethnic Asian man who was undergoing long-term warfarin therapy for antiphospholipid syndrome. The patient experienced a sudden decrease in platelet count, from 308,000 per μL from the day of admission to 38,000 per μL the following day. Follow-up testing revealed unremarkable red blood cell (RBC) morphology, no evidence of platelet clumping, and negative heparin-induced antibody test results. Platelet antibody testing revealed anti-HPA15a antibodies.
authors.affiliation: Department of Pathology, The Queen's Medical Center, Honolulu, Hawaii mobeen@hawaii.edu.
authors.forename: Mobeen
authors.initials: M
authors.lastname: Rahman
authors.affiliation: Department of Pathology, The Queen's Medical Center, Honolulu, Hawaii.
authors.forename: Ana
authors.initials: A
authors.lastname: Ortega-Lopez
authors.affiliation: Department of Pathology, The Queen's Medical Center, Honolulu, Hawaii.
authors.forename: Amy
authors.initials: A
authors.lastname: Powers
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D016824:Antigens, Human Platelet / Q000276:immunology; D044466:Asian People; D001323:Autoantibodies / Q000097:blood*; D006801:Humans; D008297:Male; D011693:Purpura / Q000209:etiology* / Q000473:pathology*; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000473:pathology*; D065227:Transfusion Reaction; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D016824:Antigens, Human Platelet; D001323:Autoantibodies; D014859:Warfarin
keywords: anti-HPA, anti-HPA 15a; human platelet antibodies; human platelet antigens; post-transfusion purpura; thrombocytopenia; transfusion reaction