title: Innate lymphoid cells: parallel checkpoints and coordinate interactions with T cells.
abstract: Protection of epithelial and mucosal surfaces is required for survival. The recent discovery of a diverse array of innate lymphoid cells that lie immediately beneath these surfaces has unexpectedly uncovered an entire defense system distinct from the adaptive system essential to protect these barriers. This multilayered design provides a robust system through coupling of two highly complementary networks to ensure immune protection. Here, we discuss the similarities in the hardwiring and diversification of innate lymphoid cells and T cells during mammalian immune responses.
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville 3010, Australia. Electronic address: huntington@wehi.edu.au.
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Huntington
authors.affiliation: MI-mAbs, Marseille 13288, France.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Carpentier
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University UM2, Inserm, U1104, CNRS UMR7280, Marseille 13288, France; Immunologie, Hôpital de la Conception, Assistance Publique - Hôpitaux de Marseille, Marseille 13385, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Vivier
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville 3010, Australia. Electronic address: belz@wehi.edu.au.
authors.forename: Gabrielle T
authors.initials: GT
authors.lastname: Belz
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000276:immunology; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000276:immunology; D050990:GATA3 Transcription Factor / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D019409:Interleukin-15 / Q000235:genetics / Q000276:immunology; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D009092:Mucous Membrane / Q000166:cytology / Q000276:immunology; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000235:genetics / Q000276:immunology; D051560:Proto-Oncogene Proteins c-bcl-6; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*
chemical_list: C084103:BCL6 protein, human; D004268:DNA-Binding Proteins; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human; C569274:IL15 protein, human; D019409:Interleukin-15; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D051560:Proto-Oncogene Proteins c-bcl-6; C539900:RORC protein, human