title: [Effect of Immunotherapy of Dendritic Cells and Cytokine-Induced Killer Cells Combined with Chemotherapy on Secreting Function of T Lymphocytes in Patients with Multiple Myeloma].
abstract: OBJECTIVE
  To evaluate the treatment value of adoptive immunotherapy (dendritic cells and cytokine-induced killer cells, DC-CIK) combined with chemotherapy on patients with multiple myeloma (MM) and its effect on secreting function of T lymphocytes in MM patients.
  
  
  METHODS
  A total of 36 patients with MM were randomly divided into two groups, among them 28 patients in chemotherapy group were treated by chemotherapy only, 28 patients in combined therapy group were treated by adoptive immunotherapy (DC-CIK) combined with chemotherapy, and the clinical outcomes and the levels of IL-2, IFN-γ, IL-4, IL-10 secreted by T lymphocytes between two groups were compared.
  
  
  RESULTS
  After treatment, the quality of life, clinical index and survival in combined therapy group were better than those in chemotherapy group (P <0.05); the levels of IL-2 and IFN-γ in combined therapy group was higher than these in chemotherapy group (P <0.05), and the levels of IL-4 and IL-10 in combined therapy group were lower than those in chemotherapy group (P <0.05).
  
  
  CONCLUSIONS
  DC-CIK combined with chemotherapy can be an effective and promising treatment for patients with MM, and it maybe strengthen the anti-tumor action of bodies by regulating the balance between Th1 and Th2 reaction.
authors.affiliation: Department of Hematology, The Central Hospital of Shengli Oil Field, Dongying 257000, Shandong Province, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Hematology, The Central Hospital of Shengli Oil Field, Dongying 257000, Shandong Province, China. E-mail: dingmx2008@126.com.
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Ding
authors.affiliation: Department of Hematology, The Central Hospital of Shengli Oil Field, Dongying 257000, Shandong Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Hematology, The Central Hospital of Shengli Oil Field, Dongying 257000, Shandong Province, China.
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Liu
authors.affiliation: Department of Hematology, The Central Hospital of Shengli Oil Field, Dongying 257000, Shandong Province, China.
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Hematology, The Central Hospital of Shengli Oil Field, Dongying 257000, Shandong Province, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xing
authors.affiliation: Department of Hematology, The Central Hospital of Shengli Oil Field, Dongying 257000, Shandong Province, China.
authors.forename: Cai-Feng
authors.initials: CF
authors.lastname: Sun
mesh_terms: D055612:Cytokine-Induced Killer Cells; D003713:Dendritic Cells; D006801:Humans; D007167:Immunotherapy; D016219:Immunotherapy, Adoptive; D016753:Interleukin-10; D007376:Interleukin-2; D015847:Interleukin-4; D009101:Multiple Myeloma; D011788:Quality of Life; D013601:T-Lymphocytes
chemical_list: C508609:IL10 protein, human; C508594:IL2 protein, human; C508598:IL4 protein, human; D007376:Interleukin-2; D016753:Interleukin-10; D015847:Interleukin-4