title: IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia patients.
abstract: Fibromyalgia (FM) is a chronic disease that has been linked to inflammatory reactions and changes in the systemic levels of proinflammatory cytokines that modulate responses in the sympathetic nervous system and hypothalamic-pituitary-adrenal axis. We found that concentrations of IL-6 and IL-8 were elevated in FM patients. Both cytokines correlated with clinical scores, suggesting that IL-6 and IL-8 have additive or synergistic effects in perpetuating the chronic pain in FM patients. These findings indicate that IL-6 and IL-8 are two of the most constant inflammatory mediators in FM and that their levels correlate significantly with the severity of symptoms.
authors.affiliation: Clinical Service, National Institute of Psychiatry "Ramón de la Fuente", Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico. Electronic address: danemend@hotmail.com.
authors.forename: Danelia
authors.initials: D
authors.lastname: Mendieta
authors.affiliation: Laboratory of Neuroimmunoendocrinology, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Avenida Insurgentes Sur 3877, La Fama, Tlalpan, 14269 Mexico City, DF, Mexico. Electronic address: cruza_dl@hotmail.com.
authors.forename: Dora Luz
authors.initials: DL
authors.lastname: De la Cruz-Aguilera
authors.affiliation: Clinical Service, National Institute of Psychiatry "Ramón de la Fuente", Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico. Electronic address: maribel_barrerav@yahoo.com.mx.
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: Barrera-Villalpando
authors.affiliation: Department of Psychoimmunology, National Institute of Psychiatry, "Ramón de la Fuente", Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico. Electronic address: lusenbeve@yahoo.com.
authors.forename: Enrique
authors.initials: E
authors.lastname: Becerril-Villanueva
authors.affiliation: Psychiatric Genetics Department, Clinical Research Branch, National Institute of Psychiatry, "Ramón de la Fuente", Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico. Electronic address: lahunsotz@yahoo.com.mx.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Arreola
authors.affiliation: Department of Psychoimmunology, National Institute of Psychiatry, "Ramón de la Fuente", Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico. Electronic address: erick.hdz.ferreira@gmail.com.
authors.forename: Erick
authors.initials: E
authors.lastname: Hernández-Ferreira
authors.affiliation: Unit of R&D in Bioprocesses (UDIBI), National School of Biological Sciences, National Polytechnic Institute, Mexico City, Mexico; Unit of Research, Development and Innovation in Medicine and Biotechnology/Transfer Factor Project (UDIMEB/PFT), National School of Biological Sciences, National Polytechnic Institute, Mexico City, Mexico. Electronic address: smpt.2011@hotmail.com.
authors.forename: Sonia Mayra
authors.initials: SM
authors.lastname: Pérez-Tapia
authors.affiliation: Department of Psychoimmunology, National Institute of Psychiatry, "Ramón de la Fuente", Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico. Electronic address: gipersanchez@hotmail.com.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Pérez-Sánchez
authors.affiliation: Department of Psychoimmunology, National Institute of Psychiatry, "Ramón de la Fuente", Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico; Unit of R&D in Bioprocesses (UDIBI), National School of Biological Sciences, National Polytechnic Institute, Mexico City, Mexico. Electronic address: me.garces.alvarez@live.com.mx.
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Garcés-Alvarez
authors.affiliation: Laboratory of Neuroimmunoendocrinology, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Avenida Insurgentes Sur 3877, La Fama, Tlalpan, 14269 Mexico City, DF, Mexico. Electronic address: mariluci_aguirre@hotmail.com.
authors.forename: Lucinda
authors.initials: L
authors.lastname: Aguirre-Cruz
authors.affiliation: School of Medicine, National Autonomous University of Mexico, Avenida Universidad 3000, Coyoacan, 04510 Mexico City, DF, Mexico. Electronic address: marcovelasco@unam.mx.
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Velasco-Velázquez
authors.affiliation: Department of Psychoimmunology, National Institute of Psychiatry, "Ramón de la Fuente", Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico. Electronic address: lkuriaki@imp.edu.mx.
authors.forename: Lenin
authors.initials: L
authors.lastname: Pavón
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D005356:Fibromyalgia / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D016209:Interleukin-8
keywords: FIQ; Fibromyalgia; IL-6; IL-8; Inflammation