title: [Clinical Values of Combined Detection of CRP and D-D for AL Patients Complicated with DIC].
abstract: OBJECTIVE
  To explore the clinical values of the combined detection of C-reactive protein (CRP) and D-dimer (D-D) for acute leukemia (AL) patients complicated with disseminated intravascular coagulation (DIC).
  
  
  METHODS
  Among 52 cases of AL, 20 cases of AL complicated with DIC were selected as AL+DIC group, 32 cases of AL were selected as AL group, 30 healthy volunteers were used as control group; the detected values of CRP and D-D in 3 groups were compared.
  
  
  RESULTS
  The CRP and D-D levels in AL+DIC group were significantly higher than those in AL and control groups (P < 0.05); the CRP and D-D levels in AL group were significatly higher than those in control group (P < 0.05). The D-D level and complicated DIC rate in patients with CRP < 10 mg/L were significantly lower than those in patients with CRP 10-100 and >100 mg/L (P <0.05), while the D-D level and complicated DIC rate in patients with 10-100 mg/L were significantly lower than those in patients with CRP > 100 mg/L (P <0.05). After treatment of patients, the CRP and D-D levels in AL and AL+DIC groups were obviously reduced as compared with levels of these 2 groups before treatment (P <0.05); the CRP and D-D levels in AL+DIC after treatment were significantly higher than those in AL group (P <0.05).
  
  
  CONCLUSIONS
  The combined detection of CRP and D-D possesses a higher reference value for diagnosis and differentiation of AL and AL complicated with DIC, thus also has an important role in evaluation of therapeutic efficacy of AL.
authors.affiliation: Department of Blood Transfusion, Lishui Municipal People's Hospital, Lishui 323000, Zhejiang Province, China. E-mail: 249629364@qq.com.
authors.forename: Xue-Hong
authors.initials: XH
authors.lastname: Ji
mesh_terms: D000208:Acute Disease; D002097:C-Reactive Protein; D004211:Disseminated Intravascular Coagulation; D005338:Fibrin Fibrinogen Degradation Products; D006801:Humans; D007938:Leukemia
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D002097:C-Reactive Protein