title: Guajavadimer A, a Dimeric Caryophyllene-Derived Meroterpenoid with a New Carbon Skeleton from the Leaves of Psidium guajava.
abstract: Guajavadimer A (1), a dimeric sesquiterpene-based meroterpenoid which possessed an unprecedented two caryophyllenes, a benzylphlorogulcinol, and a flavonone-fused complicated stereochemical skeleton, was isolated from the leaves of Psidium guajava L. Its structure and absolute configuration were elucidated on the basis of spectroscopic data and X-ray crystallography. Guajavadimer A (1) showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 10005, China.
authors.forename: Chuang-Jun
authors.initials: CJ
authors.lastname: Li
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 10005, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 10005, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 10005, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , 1 Xian Nong Tan Street, Beijing 10005, China.
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Zhang
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology; D018360:Crystallography, X-Ray; D056945:Hep G2 Cells; D006801:Humans; D008099:Liver / Q000378:metabolism; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D031647:Psidium / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C000607876:guajavadimer A; D000082:Acetaminophen; C024714:caryophyllene