title: Migration and Tissue Tropism of Innate Lymphoid Cells.
abstract: Innate lymphoid cell (ILCs) subsets differentially populate various barrier and non-barrier tissues, where they play important roles in tissue homeostasis and tissue-specific responses to pathogen attack. Recent findings have provided insight into the molecular mechanisms that guide ILC migration into peripheral tissues, revealing common features among different ILC subsets as well as important distinctions. Recent studies have also highlighted the impact of tissue-specific cues on ILC migration, and the importance of the local immunological milieu. We review these findings here and discuss how the migratory patterns and tissue tropism of different ILC subsets relate to the development and differentiation of these cells, and to ILC-mediated tissue-specific regulation of innate and adaptive immune responses. In this context we outline open questions and important areas of future research.
authors.affiliation: Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA; Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. Electronic address: chkim@purdue.edu.
authors.forename: Chang H
authors.initials: CH
authors.lastname: Kim
authors.affiliation: Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Seika
authors.initials: S
authors.lastname: Hashimoto-Hill
authors.affiliation: Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Myunghoo
authors.initials: M
authors.lastname: Kim
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D060833:Cellular Microenvironment; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D008214:Lymphocytes / Q000502:physiology*; D009928:Organ Specificity; D016201:Receptors, Lymphocyte Homing / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D016201:Receptors, Lymphocyte Homing