title: Pentraxin-3 and nitric oxide as indicators of disease severity in alcoholic cirrhosis.
abstract: Recent studies have indicated that pentraxin-3 can be used as a marker to assess the severity of hepatic fibrosis in non-alcoholic steatohepatitis. The present study was designed to assess pentraxin-3, nitric oxide and tumour necrosis factor-α (TNFα) in alcoholic cirrhosis and their association with disease severity. We enrolled 47 alcoholic cirrhosis cases and 32 controls. Serum pentraxin-3, nitric oxide (NO) and TNFα levels were estimated in both groups. Serum pentraxin-3, NO and TNFα were significantly increased in alcoholic cirrhosis patients compared to controls. Pentraxin-3 had a significant positive correlation with TNFα (r=0.303, P=0.039), Child-Pugh score (r=0.394, P=0.006) and MELD score (r=0.291, P=0.047) in alcoholic cirrhosis cases. Also we found positive association between NO with Child-Pugh score (r=0.391, P=0.007) and MELD score (r=0.311, P=0.033) in these cases. Linear regression analysis shows significant association of pentraxin-3 and NO (β=0.375, r2=0.141, P=0.009). We conclude that elevated pentraxin-3 and NO levels are associated with severity of alcoholic cirrhosis.
authors.forename: H
authors.initials: H
authors.lastname: Nandeesha
authors.forename: M
authors.initials: M
authors.lastname: Rajappa
authors.forename: J
authors.initials: J
authors.lastname: Manjusha
authors.forename: P H
authors.initials: PH
authors.lastname: Ananthanarayanan
authors.forename: T
authors.initials: T
authors.lastname: Kadhiravan
authors.forename: K T
authors.initials: KT
authors.lastname: Harichandrakumar
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D003124:Colorimetry; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016014:Linear Models; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D012680:Sensitivity and Specificity; D000683:Serum Amyloid P-Component / Q000032:analysis*; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D009569:Nitric Oxide; D000683:Serum Amyloid P-Component; D014409:Tumor Necrosis Factor-alpha; D000099153:Pentraxins