title: Functional evaluation of secondary renal amyloidosis with diffusion-weighted MR imaging.
abstract: OBJECTIVE
  This study evaluated whether diffusion-weighted magnetic resonance imaging (DW-MRI) can be used to diagnose secondary renal amyloidosis looking specifically at the diagnostic efficacy of two apparent diffusion coefficient (ADC) measurement methods as they were used with DW-MRI.
  
  
  METHODS
  The study included 24 amyloid nephropathy (AN) patients, 20 chronic kidney disease (CKD) patients, and 20 healthy volunteers (HV). ADC values were measured using two different methods: 1) the method of the region of interest indicators (ROIs) and 2) the method of drawing whole renal parenchyma (WP). The correlation between the two methods was evaluated.
  
  
  RESULTS
  ROIs could differentiate AN-CKD (p = 0.007). ROIs and WP could differentiate AN-HV (p < 0.05). However, none of the methods could differentiate CKD-HV (p > 0.05). The sensitivity and specificity of the ROIs method in differentiating AN from CKD patients for 1.8 × 10(-3) cutoff ADC values were 79% and 60% and for AN-HV patients 79% and 70%. ADC values of AN patients with GFR > 60 mL/min were lower than that of HV (p < 0.01).
  
  
  CONCLUSIONS
  DW-MRI is a useful and non-invasive diagnostic tool in diagnosing secondary renal amyloidosis and differentiating renal amyloidosis from other CKDs. ROIs had the highest sensitivity and specificity for assessing the involvement of renal amyloidosis. MRI diagnosis of AN may obviate a renal biopsy for diagnosis.
authors.affiliation: a Ankara Numune Egitim Ve Arastirma Hastanesi , Ankara , Turkey.
authors.forename: Gunay
authors.initials: G
authors.lastname: Rona
authors.affiliation: a Ankara Numune Egitim Ve Arastirma Hastanesi , Ankara , Turkey.
authors.forename: Lale
authors.initials: L
authors.lastname: Pasaoglu
authors.affiliation: a Ankara Numune Egitim Ve Arastirma Hastanesi , Ankara , Turkey.
authors.forename: Nihal
authors.initials: N
authors.lastname: Ozkayar
authors.affiliation: a Ankara Numune Egitim Ve Arastirma Hastanesi , Ankara , Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Ciliz
authors.affiliation: a Ankara Numune Egitim Ve Arastirma Hastanesi , Ankara , Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Toprak
authors.affiliation: a Ankara Numune Egitim Ve Arastirma Hastanesi , Ankara , Turkey.
authors.forename: Tunca
authors.initials: T
authors.lastname: Kaya
authors.affiliation: a Ankara Numune Egitim Ve Arastirma Hastanesi , Ankara , Turkey.
authors.forename: Gizem
authors.initials: G
authors.lastname: Abat
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
keywords: Secondary amyloidosis; chronic kidney disease; diffusion-weighted imaging; kidney; magnetic resonance imaging