title: MoS2-Gd Chelate Magnetic Nanomaterials with Core-Shell Structure Used as Contrast Agents in in Vivo Magnetic Resonance Imaging.
abstract: Despite their frequent usages as contrast agents for in vivo MRI imaging, paramagnetic molecules continue to suffer from low resolution, physicochemical instability, and high toxicity. Herein, we present a molybdenum disulfide and gadolinium complex, as an alternative core-shell magnetic nanomaterial that exhibits enhanced paramagnetic property; 4.5-times longer water proton spin-lattice relaxation time (T1) when compared to commercial gadolinium contrast agents; as well as lowered toxicity, extended blood circulation time, increased stability, and desirable excretion characteristic. Transmission electron microscopy (TEM) revealed smooth core-shell nanoparticles 100 nm in size with a shell width of approximately 10 nm. These findings suggest that the synthesized nanomaterial possesses high potential as a positive contrast agent for the enhancement of MRI imaging.
authors.affiliation: Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology , Taipei 106, Taiwan.
authors.forename: Rajeshkumar
authors.initials: R
authors.lastname: Anbazhagan
authors.affiliation: Institute Polymer Science and Engineering, National Taiwan University , Taipei 106, Taiwan.
authors.forename: Yu-An
authors.initials: YA
authors.lastname: Su
authors.affiliation: Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology , Taipei 106, Taiwan.
authors.forename: Hsieh-Chih
authors.initials: HC
authors.lastname: Tsai
authors.affiliation: Institute Polymer Science and Engineering, National Taiwan University , Taipei 106, Taiwan.
authors.forename: Ru-Jong
authors.initials: RJ
authors.lastname: Jeng
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000737:chemistry* / Q000494:pharmacology; D003287:Contrast Media / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry* / Q000494:pharmacology; D005260:Female; D005682:Gadolinium / Q000737:chemistry* / Q000494:pharmacology; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D060328:Magnetic Phenomena; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008813:Mice, Inbred ICR; D008982:Molybdenum / Q000737:chemistry* / Q000494:pharmacology; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D056951:Photoelectron Spectroscopy; D012815:Signal Processing, Computer-Assisted; D055672:Static Electricity; D013816:Thermodynamics
chemical_list: D002614:Chelating Agents; D003287:Contrast Media; D004220:Disulfides; D008982:Molybdenum; D005682:Gadolinium; C082964:molybdenum disulfide
keywords: contrast agents; core−shell structure; enhanced T1 value; in vivo imaging enhanced excretion; molybdenum disulfide nanoparticle