title: Design and characterization of chitosan/zeolite composite films--Effect of zeolite type and zeolite dose on the film properties.
abstract: Chitosan films can be used as wound dressings for the treatment of chronic wounds and severe burns. The antimicrobial properties of these films may be enhanced by the addition of silver. Despite the antimicrobial activity of silver, several studies have reported the cytotoxicity as a factor limiting its biomedical applications. This problem may, however, be circumvented by the provision of sustained release of silver. Silver zeolites can be used as drug delivery platforms to extend the release of silver. The objective of this study was to evaluate the addition of clinoptilolite and A-type zeolites in chitosan films. Sodium zeolites were initially subjected to ion-exchange in a batch reactor. Films were prepared by casting technique using a 2% w/w chitosan solution and two zeolite doses (0.1 or 0.2% w/w). Films were characterized by thermal analysis, color analysis, scanning electron microscopy, X-ray diffraction, and water vapor permeation. The results showed that films present potential for application as dressing. The water vapor permeability is one of the main properties in wound dressings, the best results were obtained for A-type zeolite/chitosan films, which presented a brief reduction of this property in relation to zeolite-free chitosan film. On the other hand, the films containing clinoptilolite showed lower water vapor permeation, which may be also explained by the best distribution of the particles into the polymer which also promoted greater thermal resistance.
authors.affiliation: Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Diadema, Brazil.
authors.forename: Gustavo P
authors.initials: GP
authors.lastname: Barbosa
authors.affiliation: Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Diadema, Brazil.
authors.forename: Henrique S
authors.initials: HS
authors.lastname: Debone
authors.affiliation: Universidade Tiradentes, Instituto de Tecnologia e Pesquisa, Aracaju, Brazil.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Severino
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal; Center for Neuroscience and Cell Biology & Institute for Biomedical Imaging and Life Sciences (CNC-IBILI), University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.
authors.forename: Eliana B
authors.initials: EB
authors.lastname: Souto
authors.affiliation: Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Diadema, Brazil. Electronic address: cfsilva@unifesp.br.
authors.forename: Classius F
authors.initials: CF
authors.lastname: da Silva
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D014961:X-Ray Diffraction; D017641:Zeolites / Q000737:chemistry*
chemical_list: D008567:Membranes, Artificial; D017641:Zeolites; D048271:Chitosan
keywords: Chitosan; Clinoptilolite; Dressings; Films; Silver; Type-A zeolite; Zeolite; Zeolites