title: Nasal angiosarcoma metastatic to the larynx: Case report and systematic review of the literature.
abstract: BACKGROUND
  Laryngeal angiosarcoma is rare and the prognosis is poor. The purpose of this study was to describe the first case of cutaneous angiosarcoma metastatic to the larynx and systematically review all cases of laryngeal angiosarcoma.
  
  
  METHODS
  A 61-year-old man presented with an alar lesion diagnosed as angiosarcoma and was treated with wide local resection and radiation. Six years later, he presented with a laryngeal mass histologically similar to the initial tumor. A systematic review of reported cases of angiosarcoma of the larynx was performed.
  
  
  RESULTS
  Eighteen cases were identified. Mean age of presentation was 64.3 years. Men represented 66.7%. Mean follow-up was 34.1 months. Forty-seven percent died with disseminated disease at a mean of 18.4 months. Our patient did well with serial resection.
  
  
  CONCLUSIONS
  To the best of our knowledge, this case represents the first documented case of cutaneous angiosarcoma metastatic to the larynx and suggests that serial resection with long-term surveillance may be of benefit in some cases.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, University of Minnesota Medical School, Minneapolis, Minnesota.
authors.forename: Hannah E
authors.initials: HE
authors.lastname: Qualls
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Washington, Seattle, Washington.
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Mitchell
authors.affiliation: Department of Pathology, University of Washington, Seattle, Washington (retired).
authors.forename: Heike
authors.initials: H
authors.lastname: Deubner
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Washington, Seattle, Washington.
authors.forename: Kris S
authors.initials: KS
authors.lastname: Moe
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Washington, Seattle, Washington.
authors.forename: Maya
authors.initials: M
authors.lastname: Sardesai
mesh_terms: D006394:Hemangiosarcoma / Q000556:secondary*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000473:pathology*
keywords: angiosarcoma; laryngeal angiosarcoma; larynx; metastasis; systematic review