title: HDACi and Nrf2: not from alpha to omega but from acetylation to OA.
abstract: Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is probably the most important ubiquitously expressed little protein that you have never heard of. Discovered more than 20 years ago, it is now known as a master regulator of redox homeostasis, controlling a plethora of cytoprotective phase II anti-oxidant enzymes. Regulation of gene expression by histone acetyltransferases and histone deacetylases drives the etiology of many age-related human diseases, including osteoarthritis. In Arthritis Research & Therapy, Cai et al. explore systemic histone deacetylase inhibition as a strategy to prevent osteoarthritis and identify a role for Nrf2 in preventing cartilage degeneration.
authors.affiliation: Department of Orthopaedic Surgery, University Hospital RWTH Aachen, Pauwelsstraβe 30, 52074, Aachen, Germany. hjahr@ukaachen.de.
authors.forename: Holger
authors.initials: H
authors.lastname: Jahr
mesh_terms: D000107:Acetylation / Q000187:drug effects; D000818:Animals; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D051267:NF-E2-Related Factor 2 / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D010003:Osteoarthritis / Q000378:metabolism*
chemical_list: D056572:Histone Deacetylase Inhibitors; D051267:NF-E2-Related Factor 2; C495636:Nfe2l2 protein, mouse