title: Examination of neurological prognostic markers in patients with respiratory syncytial virus-associated encephalopathy.
abstract: No biomarker has been established as a prognostic indicator of acute encephalopathy associated with various etiological factors. In this study, we examined useful prognostic biomarkers in patients with acute encephalopathy associated with respiratory syncytial virus (RSV) infection. The subjects were 11 children with RSV-associated encephalopathy admitted to our hospital. We measured the levels of interleukin (IL)-6, brain-derived neurotrophic factor (BDNF) and nitrogen oxide (NO)xin cerebrospinal fluid collected on the day of admission. Using the pediatric cerebral performance categories (PCPC) score as a prognostic indicator, we evaluated the association between the biomarkers and neurologic prognosis. Concerning neurologic prognosis, sequelae were noted in more than 50% of the subjects. There was no association between prognosis and age/sex. Increases in the levels of all biomarkers were observed in all subjects. IL-6 and BDNF levels were correlated with PCPC score, but not with NOx. Of the biomarkers investigated, the IL-6 and BDNF levels in cerebrospinal fluid were shown to be correlated with neurologic prognosis. Because many patients with this disease had severe sequelae, assessment should be conducted by early evaluation of the biomarkers examined in this study with respect to the clinical course.
authors.affiliation: a Department of Pediatrics , Tokyo Medical University , Tokyo , Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Morichi
authors.affiliation: a Department of Pediatrics , Tokyo Medical University , Tokyo , Japan.
authors.forename: Natsumi
authors.initials: N
authors.lastname: Morishita
authors.affiliation: a Department of Pediatrics , Tokyo Medical University , Tokyo , Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Ishida
authors.affiliation: a Department of Pediatrics , Tokyo Medical University , Tokyo , Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Oana
authors.affiliation: a Department of Pediatrics , Tokyo Medical University , Tokyo , Japan.
authors.forename: Gaku
authors.initials: G
authors.lastname: Yamanaka
authors.affiliation: a Department of Pediatrics , Tokyo Medical University , Tokyo , Japan.
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Kashiwagi
authors.affiliation: a Department of Pediatrics , Tokyo Medical University , Tokyo , Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kawashima
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000134:cerebrospinal fluid; D019208:Brain-Derived Neurotrophic Factor / Q000134:cerebrospinal fluid*; D002648:Child; D002675:Child, Preschool; D018792:Encephalitis, Viral / Q000134:cerebrospinal fluid* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000134:cerebrospinal fluid*; D008297:Male; D009589:Nitrogen Oxides / Q000134:cerebrospinal fluid*; D011379:Prognosis; D018357:Respiratory Syncytial Virus Infections / Q000134:cerebrospinal fluid*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; C508600:IL6 protein, human; D015850:Interleukin-6; D009589:Nitrogen Oxides; C579455:BDNF protein, human
keywords: RS virus; acute encephalopathy; brain-derived neurotrophic factor (BDNF); interleukin-6; nitrogen oxide (NO); sequelae