title: Anti-diabetic activities of Paecilomyces tenuipes N45 extract in alloxan-induced diabetic mice.
abstract: Due to the limitations of existing anti-diabetic drugs, the treatment of diabetes mellitus remains a significant challenge. The present study aimed to investigate the hypoglycemic, hypolipidemic and antioxidant effects of Paecilomyces tenuipes N45 extracts on alloxan-induced type I diabetes mellitus in mice. Diabetic Kunming mice were orally administered with water extract (WE) at doses of 2.50, 0.25 and 0.05 g/kg) or alcohol extract (AE) at doses of 2.00, 0.20 and 0.04 g/kg, for 3 weeks, following which the levels of factors associated with blood glucose, lipids and free radicals were determined. The anti-diabetic activities of AE and WE were further confirmed via an oral glucose tolerance test. Similar to the effects of metformin, Paecilomyces tenuipes N45 extracts led to a significant reduction in blood glucose levels, increase in serum insulin concentration and normalization in the densities of low-density lipoprotein cholesterol and high density lipoprotein cholesterol. The Paecilomyces tenuipes N45 extracts exerted antioxidative effects, indicated by regulation in the levels of superoxide dismutase, malondialdehyde and glutathione peroxidase. Taken together, the results of the present study demonstrated that Paecilomyces tenuipes N45 extract, a safe pharmaceutical agent, exerted anti-diabetic and anti-nephropathic activities and, thus, offers potential as a novel therapeutic agent in the treatment of diabetes.
authors.affiliation: School of Life Science, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Linna
authors.initials: L
authors.lastname: Du
authors.affiliation: School of Life Science, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Chungang
authors.initials: C
authors.lastname: Liu
authors.affiliation: School of Life Science, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Meiyu
authors.initials: M
authors.lastname: Teng
authors.affiliation: School of Life Science, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Qingfan
authors.initials: Q
authors.lastname: Meng
authors.affiliation: School of Life Science, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Lu
authors.affiliation: School of Life Science, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: School of Life Science, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Life Science, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Yingkun
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: School of Life Science, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.affiliation: School of Life Science, Jilin University, Changchun, Jilin 130012, P.R. China.
authors.forename: Lesheng
authors.initials: L
authors.lastname: Teng
mesh_terms: D000496:Alloxan; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D005951:Glucose Tolerance Test; D006003:Glycogen / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010143:Paecilomyces / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007328:Insulin; D010936:Plant Extracts; D000496:Alloxan; D006003:Glycogen