title: DNA Nanotechnology for Precise Control over Drug Delivery and Gene Therapy.
abstract: Nanomedicine has been growing exponentially due to its enhanced drug targeting and reduced drug toxicity. It uses the interactions where nanotechnological components and biological systems communicate with each other to facilitate the delivery performance. At this scale, the physiochemical properties of delivery systems strongly affect their capacities. Among current delivery systems, DNA nanotechnology shows many advantages because of its unprecedented engineering abilities. Through molecular recognition, DNA nanotechnology can be used to construct a variety of nanostructures with precisely controllable size, shape, and surface chemistry, which can be appreciated in the delivery process. In this review, different approaches that are currently used for the construction of DNA nanostructures are reported. Further, the utilization of these DNA nanostructures with the well-defined parameters for the precise control in drug delivery and gene therapy is discussed.
authors.affiliation: Department of NanoEngineering, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: Chava
authors.initials: C
authors.lastname: Angell
authors.affiliation: Department of NanoEngineering, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: Sibai
authors.initials: S
authors.lastname: Xie
authors.affiliation: Department of NanoEngineering, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: Liangfang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of NanoEngineering, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
mesh_terms: D004247:DNA / Q000737:chemistry*; D016503:Drug Delivery Systems; D015316:Genetic Therapy; D006801:Humans; D036103:Nanotechnology
chemical_list: D004247:DNA
keywords: DNA nanotechnology; drug delivery; gene therapy