title: Case report of Graves' disease manifesting with odynophagia and heartburn.
abstract: Graves' disease is an autoimmune disease, which can manifest with a variety of extrathyroidal clinical syndromes like ophthalmopathy, pretibial myxedema (dermopathy), acropathy, cardiomyopathy, and encephalopathy. Though quite rare, this disease can also manifest with gastrointestinal symptoms such as dysphagia, heartburn, nausea, vomiting and diarrhea. We report a clinical case of Graves' disease manifesting with dysfunction of the esophagus and heartburn in a 61-year-old man. In the muscular layer of the esophagus we found dystrophic changes led to its atony, which was documented by endoscopy and high-resolution manometry. The pathology features of esophageal symptoms were: focal proliferation of the basal cells, vascular distension, and dystrophy of the epithelial cells. Antithyroid treatment led to decrease of all clinical symptoms after 5 d of Thiamazole administration. Complete restoration of peristalsis in the esophagus, according to manometry, was observed in 1 mo after initiation of treatment.
authors.affiliation: Yulia Evsyutina, Alexander Trukhmanov, Vladimir Ivashkin, Olga Storonova, Department of Internal Disease Propaedeutics, Gastroenterology and Hepatology, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
authors.forename: Yulia
authors.initials: Y
authors.lastname: Evsyutina
authors.affiliation: Yulia Evsyutina, Alexander Trukhmanov, Vladimir Ivashkin, Olga Storonova, Department of Internal Disease Propaedeutics, Gastroenterology and Hepatology, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Trukhmanov
authors.affiliation: Yulia Evsyutina, Alexander Trukhmanov, Vladimir Ivashkin, Olga Storonova, Department of Internal Disease Propaedeutics, Gastroenterology and Hepatology, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Ivashkin
authors.affiliation: Yulia Evsyutina, Alexander Trukhmanov, Vladimir Ivashkin, Olga Storonova, Department of Internal Disease Propaedeutics, Gastroenterology and Hepatology, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Storonova
authors.affiliation: Yulia Evsyutina, Alexander Trukhmanov, Vladimir Ivashkin, Olga Storonova, Department of Internal Disease Propaedeutics, Gastroenterology and Hepatology, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
authors.forename: Elina
authors.initials: E
authors.lastname: Godjello
mesh_terms: D013956:Antithyroid Agents / Q000627:therapeutic use; D001706:Biopsy; D003679:Deglutition; D003680:Deglutition Disorders / Q000209:etiology* / Q000503:physiopathology; D004945:Esophagoscopy; D004947:Esophagus / Q000473:pathology / Q000503:physiopathology*; D006111:Graves Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006356:Heartburn / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D013956:Antithyroid Agents
keywords: Dysfunction; Esophagopathy; Graves’ disease; Heartburn; Odynophagia