title: TCC in Transplant Ureter--When and When Not to Preserve the Transplant Kidney.
abstract: We present four cases of transitional cell carcinoma of the transplant ureter (TCCtu). In three cases, localized tumor resection and a variety of reconstructive techniques were possible. Transplant nephrectomy with cystectomy was performed as a secondary treatment in one locally excised case. Transplant nephroureterectomy was performed as primary treatment in one case. The role of oncogenic viruses and genetic fingerprinting to determine the origin of TCCtu are described. Our cases and a systematic literature review illustrate the surgical, nephrological, and oncological challenges of this uncommon but important condition.
authors.affiliation: Department of Renal Transplantation and Pathology, Guy's Hospital, London, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Olsburgh
authors.affiliation: Department of Renal Transplantation and Pathology, Guy's Hospital, London, United Kingdom.
authors.forename: R H
authors.initials: RH
authors.lastname: Zakri
authors.affiliation: Department of Renal Transplantation and Pathology, Guy's Hospital, London, United Kingdom.
authors.forename: C
authors.initials: C
authors.lastname: Horsfield
authors.affiliation: Department of Renal Transplantation and Pathology, Guy's Hospital, London, United Kingdom.
authors.forename: R
authors.initials: R
authors.lastname: Collins
authors.affiliation: Department of Renal Transplantation and Pathology, Guy's Hospital, London, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Fairweather
authors.affiliation: Department of Renal Transplantation and Pathology, Guy's Hospital, London, United Kingdom.
authors.forename: P
authors.initials: P
authors.lastname: O'Donnell
authors.affiliation: Department of Renal Transplantation and Pathology, Guy's Hospital, London, United Kingdom.
authors.forename: G
authors.initials: G
authors.lastname: Koffman
mesh_terms: D000293:Adolescent; D000328:Adult; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D005919:Glomerular Filtration Rate; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D007677:Kidney Function Tests; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000209:etiology; D016030:Kidney Transplantation; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D011183:Postoperative Complications; D011379:Prognosis; D012307:Risk Factors; D019737:Transplants; D014513:Ureter / Q000601:surgery / Q000637:transplantation*; D055815:Young Adult
keywords: cancer/malignancy/neoplasia; clinical research/practice; kidney transplantation/nephrology; kidney disease: malignant