title: Serum Cystatin C and the Risk of Coronary Heart Disease in Ethnic Chinese Patients With Normal Renal Function.
abstract: BACKGROUND
  Cystatin C, a marker for early stage chronic kidney dysfunction, mediates the pathogenesis of cardiovascular diseases.
  
  
  OBJECTIVE
  To investigate whether serum cystatin C is an independent predictor of coronary heart disease (CHD) for patients without chronic kidney disease (CKD).
  
  
  METHODS
  In this cross-sectional study, we included 525 patients with CHD and 142 apparently healthy control individuals and acquired their demographic characteristics, medical histories, and listings of the concurrent medications they were taking. All patients with CHD underwent coronary angiography and other routine laboratory examinations. We quantified serum concentrations of cystatin C via particle-enhanced immunonephelometric assay.
  
  
  RESULTS
  Compared with controls, the patients with CHD had higher serum cystatin C levels (median: 1.17 mg/L, interquartile range [IQR]: 1.01 to 1.46 mg/L vs median: 0.98 mg/L, IQR: 0.80 to 1.06 mg/L, P <.001), lower levels of high-density lipoprotein cholesterol (P <.001), higher levels of low-density lipoprotein cholesterol (P <.001), triglyceride (P <.001), total cholesterol (P = .007) and high-sensitivity C-reactive protein (P <.001). No differences occurred in serum concentrations of creatinine or estimated glomerular filtration rate between CHD patients and healthy controls. Multivariate logistic regression indicated that levels of cystatin C (OR, 1.648; 95% confidence interval [CI], 1.454 to 1.868; P <.001) were most strongly correlated with CHD prevalence.
  
  
  CONCLUSIONS
  Elevated serum cystatin C is a potential biochemical marker for the prediction of CHD, which suggests that mild preclinical renal dysfunction may be associated with the pathogenesis of CHD.
authors.affiliation: Clinical Laboratory Department, Renmin Hospital of Wuhan University, Wuhan, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhao
authors.affiliation: Clinical Laboratory Department, Renmin Hospital of Wuhan University, Wuhan, China yanlitf1120@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Clinical Laboratory Department, Renmin Hospital of Wuhan University, Wuhan, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Dai
mesh_terms: D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000097:blood*; D003327:Coronary Disease / Q000175:diagnosis* / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D044967:Serum / Q000737:chemistry*
chemical_list: D015415:Biomarkers; D055316:Cystatin C
keywords: chronic kidney disease; coronary heart disease; cystatin C; glomerular filtration rate