title: Platelet Transfusion and Thrombosis: More Questions than Answers.
abstract: Platelets perform a vital role in hemostasis and their role in inflammation is becoming increasingly evident. Blood transfusion is the most common procedure performed in hospitals and platelet transfusions comprise a significant proportion. Over the past few decades, retrospective studies and randomized clinical trials have demonstrated that blood transfusion is more harmful than previously thought and is associated with numerous complications, such as transfusion-associated lung injury, transfusion-associated cardiac overload, transfusion-associated immune modulation, and infectious diseases such as human immunodeficiency virus, hepatitis C virus, and hepatitis B virus. Recent data suggest an association between platelet transfusion and thrombosis. This review will highlight the mechanistic issues that may be relevant to the epidemiologic associations of platelet transfusion with thrombosis and mortality in critically ill patients.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Schmidt
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York.
authors.forename: Majed A
authors.initials: MA
authors.lastname: Refaai
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York.
authors.forename: Neil
authors.initials: N
authors.lastname: Blumberg
mesh_terms: D055371:Acute Lung Injury / Q000097:blood / Q000209:etiology; D017848:Blood-Borne Pathogens; D006801:Humans; D017713:Platelet Transfusion / Q000009:adverse effects*; D016032:Randomized Controlled Trials as Topic; D013927:Thrombosis / Q000097:blood / Q000209:etiology; D014777:Virus Diseases / Q000097:blood / Q000635:transmission