title: [Management of periprosthetic infections of the knee].
abstract: Endoprosthetic replacement is one of the most successful operations in current medicine. As the implantation of knee prostheses increases, the number of periprosthetic infections is also rising. In case of painful or early loosening of the prosthesis an infection should be excluded by joint aspiration. Retention of the prosthesis with change of mobile parts is possible only in acute infections (< 4 weeks after surgery or duration of symptoms of <3 weeks in the case of hematogenous infection), if the prosthesis is stable, the soft tissue is intact, and no difficult-to-treat pathogens were found. In other cases a one- or two-stage prosthesis exchange should be performed. In a two-stage exchange, a short interval of 2-3 weeks is possible, if biofilm-active treatment is available. Rifampin should be used targeted (after isolation of the pathogen) and only in combination with another efficient antibiotic. In this article the current management concepts of periprosthetic infection of the knee are discussed.
authors.affiliation: Zentrum für septische Chirurgie, Centrum für Muskuloskeletale Chirurgie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.
authors.forename: N
authors.initials: N
authors.lastname: Renz
authors.affiliation: Zentrum für septische Chirurgie, Centrum für Muskuloskeletale Chirurgie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Perka
authors.affiliation: Zentrum für septische Chirurgie, Centrum für Muskuloskeletale Chirurgie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland. andrej.trampuz@charite.de.
authors.forename: A
authors.initials: A
authors.lastname: Trampuz
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D020878:Device Removal / Q000379:methods; D019317:Evidence-Based Medicine; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects*; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000209:etiology*; D012086:Reoperation / Q000379:methods; D012293:Rifampin / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D012293:Rifampin
keywords: Antibiotic treatment; Biofilm; Management; Periprosthetic joint infection