title: N6-Methylated Adenosine in RNA: From Bacteria to Humans.
abstract: N6-methyladenosine (m(6)A) is ubiquitously present in the RNA of living organisms from Escherichia coli to humans. Methyltransferases that catalyze adenosine methylation are drastically different in specificity from modification of single residues in bacterial ribosomal or transfer RNA to modification of thousands of residues spread among eukaryotic mRNA. Interactions that are formed by m(6)A residues range from RNA-RNA tertiary contacts to RNA-protein recognition. Consequences of the modification loss might vary from nearly negligible to complete reprogramming of regulatory pathways and lethality. In this review, we summarized current knowledge on enzymes that introduce m(6)A modification, ways to detect m(6)A presence in RNA and the functional role of this modification everywhere it is present, from bacteria to humans.
authors.affiliation: Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia. Electronic address: petya@genebee.msu.su.
authors.forename: Petr V
authors.initials: PV
authors.lastname: Sergiev
authors.affiliation: Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia.
authors.forename: Anna Ya
authors.initials: AY
authors.lastname: Golovina
authors.affiliation: Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia.
authors.forename: Ilya A
authors.initials: IA
authors.lastname: Osterman
authors.affiliation: Skolkovo Institute for Science and Technology, Moscow 143025, Russia.
authors.forename: Michail V
authors.initials: MV
authors.lastname: Nesterchuk
authors.affiliation: Skolkovo Institute for Science and Technology, Moscow 143025, Russia.
authors.forename: Olga V
authors.initials: OV
authors.lastname: Sergeeva
authors.affiliation: Skolkovo Institute for Science and Technology, Moscow 143025, Russia.
authors.forename: Anastasia A
authors.initials: AA
authors.lastname: Chugunova
authors.affiliation: Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia.
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Evfratov
authors.affiliation: Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia.
authors.forename: Ekaterina S
authors.initials: ES
authors.lastname: Andreianova
authors.affiliation: Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia.
authors.forename: Philipp I
authors.initials: PI
authors.lastname: Pletnev
authors.affiliation: Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia.
authors.forename: Ivan G
authors.initials: IG
authors.lastname: Laptev
authors.affiliation: Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia.
authors.forename: Kirill S
authors.initials: KS
authors.lastname: Petriukov
authors.affiliation: Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia.
authors.forename: Tsimafei I
authors.initials: TI
authors.lastname: Navalayeu
authors.affiliation: Skolkovo Institute for Science and Technology, Moscow 143025, Russia.
authors.forename: Victor E
authors.initials: VE
authors.lastname: Koteliansky
authors.affiliation: Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia.
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Bogdanov
authors.affiliation: Department of Chemistry, Department of Bioengineering and Bioinformatics and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia.
authors.forename: Olga A
authors.initials: OA
authors.lastname: Dontsova
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D008780:Methyltransferases / Q000378:metabolism; D012313:RNA / Q000378:metabolism*
chemical_list: D012313:RNA; C010223:N-methyladenosine; D008780:Methyltransferases; D000241:Adenosine
keywords: RNA modification; m(6)A; methyltransferase; rlmF; rlmJ