title: Tailored Synthesis of Octopus-type Janus Nanoparticles for Synergistic Actively-Targeted and Chemo-Photothermal Therapy.
abstract: A facile, reproducible, and scalable method was explored to construct uniform Au@poly(acrylic acid) (PAA) Janus nanoparticles (JNPs). The as-prepared JNPs were used as templates to preferentially grow a mesoporous silica (mSiO2 ) shell and Au branches separately modified with methoxy-poly(ethylene glycol)-thiol (PEG) to improve their stability, and lactobionic acid (LA) for tumor-specific targeting. The obtained octopus-type PEG-Au-PAA/mSiO2 -LA Janus NPs (PEG-OJNP-LA) possess pH and NIR dual-responsive release properties. Moreover, DOX-loaded PEG-OJNP-LA, upon 808 nm NIR light irradiation, exhibit obviously higher toxicity at the cellular and animal levels compared with chemotherapy or photothermal therapy alone, indicating the PEG-OJNP-LA could be utilized as a multifunctional nanoplatform for in vitro and in vivo actively-targeted and chemo-photothermal cancer therapy.
authors.affiliation: Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin, 130024, P. R. China.
authors.forename: Lingyu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130021, P. R. China.
authors.forename: Yinyin
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, 609 Charles E. Yong Dr. E, Los Angeles, CA, 90095, USA.
authors.forename: Zilu
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin, 130024, P. R. China. lil106@nenu.edu.cn.
authors.forename: Lu
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, 609 Charles E. Yong Dr. E, Los Angeles, CA, 90095, USA.
authors.forename: Philippe
authors.initials: P
authors.lastname: Saint-Cricq
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130021, P. R. China. cxli@ciac.ac.cn.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Li
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130021, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin, 130024, P. R. China. wangcg925@nenu.edu.cn.
authors.forename: Chungang
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin, 130024, P. R. China.
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Su
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, 609 Charles E. Yong Dr. E, Los Angeles, CA, 90095, USA.
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Zink
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004187:Disaccharides / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D007259:Infrared Rays; D007834:Lasers; D051379:Mice; D008815:Mice, Inbred Strains; D053758:Nanoparticles / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D050607:Organogold Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology; D012822:Silicon Dioxide / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D004187:Disaccharides; D050607:Organogold Compounds; D011092:Polyethylene Glycols; C006903:carbopol 940; C005608:lactobionic acid; D012822:Silicon Dioxide
keywords: active targeting; chemo-photothermal therapy; dual-stimuli responsive release; octopus-type Janus nanoparticles