title: Association between IL-10 gene polymorphisms and the risk of ischemic stroke in a Chinese population.
abstract: We investigated the possible association between two SNPs of IL-10 (IL-10 -1082A/G and -819T/C) and the susceptibility to ischemic stroke. Patients with proven ischemic stroke and control subjects were recruited between March 2013 and May 2015. The IL-10 -1082A/G and -819T/C polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Conditional logistic regression analyses revealed that the GA and the AA genotypes were associated with development of ischemic stroke, and the ORs (95% CI) for the GA and the AA genotypes of IL-10 -1082A/G were 1.49 (1.01-2.19) and 1.83 (1.02-3.29) compared with the GG genotype, respectively. In dominant model, the GA+AA genotype of IL-10 -1082G/A was correlated with increased risk of ischemic stroke compared to the GG genotype (OR=1.56, 95% CI=1.08-2.25). The GA+AA genotype was associated with moderately increased risk of ischemic stroke in smokers (OR=1.72, 95% CI=1.04-2.84). In conclusion, our study suggests that IL-10 gene polymorphisms contribute to the development of ischemic stroke, especially in tobacco smokers.
authors.affiliation: Department of Neurology, Bayannaoer Hospital Bayannaoer, China.
authors.forename: Wen
authors.initials: W
authors.lastname: He
authors.affiliation: Department of Neurology, Bayannaoer Hospital Bayannaoer, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Song
authors.affiliation: Department of Internal Medicine, Affiliated Hospital, Inner Mongolia Medical University Hohhot, China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Ding
authors.affiliation: Department of Biochemical and Molecular Biology, Inner Mongolia Medical University Hohhot, China.
authors.forename: Cunbao
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Anthropotomy, School of Basic Medicine, Inner Mongolia Medical University Hohhot, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Dai
authors.affiliation: Department of Anthropotomy, School of Basic Medicine, Inner Mongolia Medical University Hohhot, China.
authors.forename: Shang
authors.initials: S
authors.lastname: Gao
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D020521:Stroke / Q000209:etiology / Q000235:genetics*
chemical_list: D016753:Interleukin-10
keywords: IL-10; ischemic stroke; polymorphism