title: Secondary neuroendocrine tumor after allogeneic bone marrow transplantation.
abstract: Here we report a case of aggressive neuroendocrine tumor (NET), which is an extremely rare secondary solid tumor that occurs after allogeneic hematopoietic cell transplantation (allo-HSCT). A patient with chronic active Epstein-Barr virus infection received allo-HSCT from an HLA-DR two allele-mismatched unrelated donor. Four years later, he developed NET with multiple metastases. He received thoraco-abdominal irradiation as a conditioning regimen, and developed repeated episodes of intestinal graft-versus-host disease, for which he received long-term immunosuppressive therapy. Although these factors may be potential contributing factors to the development of secondary NET, the exact pathogenesis remains unclear.
authors.affiliation: Department of Pediatrics, Matsushita Memorial Hospital.|Department of Pediatrics, Kyoto City Hospital.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Tamura
authors.affiliation: Department of Pediatrics, Matsushita Memorial Hospital.|Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ishida
authors.affiliation: Department of Pediatrics, Matsushita Memorial Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Naito
authors.affiliation: Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka.
authors.forename: Osamu
authors.initials: O
authors.lastname: Kondo
authors.affiliation: Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka.
authors.forename: Masami
authors.initials: M
authors.lastname: Inoue
authors.affiliation: Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka.
authors.forename: Keisei
authors.initials: K
authors.lastname: Kawa
authors.affiliation: Department of Pathology, Matsushita Memorial Hospital, Moriguchi.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kawabata
authors.affiliation: Department of Pathology and Diagnostic Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hojo
authors.affiliation: Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ouchi
authors.affiliation: Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Imamura
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D020031:Epstein-Barr Virus Infections / Q000601:surgery*; D017809:Fatal Outcome; D006086:Graft vs Host Disease / Q000150:complications*; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000209:etiology*; D014184:Transplantation, Homologous
keywords: allogeneic hematopoietic stem cell transplantation; chronic active Epstein-Barr virus infection; neuroendocrine tumor; secondary solid tumor