title: Percutaneous Isolated Hepatic Perfusion for the Treatment of Unresectable Liver Malignancies.
abstract: Liver malignancies are a major burden of disease worldwide. The long-term prognosis for patients with unresectable tumors remains poor, despite advances in systemic chemotherapy, targeted agents, and minimally invasive therapies such as ablation, chemoembolization, and radioembolization. Thus, the demand for new and better treatments for malignant liver tumors remains high. Surgical isolated hepatic perfusion (IHP) has been shown to be effective in patients with various hepatic malignancies, but is complex, associated with high complication rates and not repeatable. Percutaneous isolated liver perfusion (PHP) is a novel minimally invasive, repeatable, and safer alternative to IHP. PHP is rapidly gaining interest and the number of procedures performed in Europe now exceeds 200. This review discusses the indications, technique and patient management of PHP and provides an overview of the available data.
authors.affiliation: Department of Radiology, Leiden University Medical Centre, Postal Zone C2-S, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. m.c.burgmans@lumc.nl.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Burgmans
authors.affiliation: Department of Surgery, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.
authors.forename: Eleonora M
authors.initials: EM
authors.lastname: de Leede
authors.affiliation: Department of Anesthesiology, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.
authors.forename: Christian H
authors.initials: CH
authors.lastname: Martini
authors.affiliation: Department of Medical Oncology, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.
authors.forename: Ellen
authors.initials: E
authors.lastname: Kapiteijn
authors.affiliation: Department of Surgery, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Vahrmeijer
authors.affiliation: Department of Radiology, Leiden University Medical Centre, Postal Zone C2-S, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.
authors.forename: Arian R
authors.initials: AR
authors.lastname: van Erkel
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*; D008558:Melphalan / Q000008:administration & dosage
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan
keywords: Interventional oncology; Liver/hepatic; Melphalan; Percutaneous hepatic perfusion