title: Regional gastrointestinal transit times in severe ulcerative colitis.
abstract: BACKGROUND
  Gastrointestinal (GI) dysmotility may present secondary to inflammatory bowel disease. The main aim of this study was to investigate GI motility in ulcerative colitis (UC) patients during severe disease activity.
  
  
  METHODS
  Twenty patients with severe UC were studied with a novel telemetric capsule system (3D-Transit) designed for minimally invasive, ambulatory assessment of total and regional GI transit times. Ten patients were available for follow-up during remission. Data were compared to those of 20 healthy subjects (HS).
  
  
  RESULTS
  Total GI transit time was significantly longer in patients with severe UC (median 44.5 h [range 9.9-102.7 h]) than in HS (median 27.6 h [range 9.6-56.4 h]) (p = 0.032). Additionally, during severe UC, transit time was prolonged through the proximal colon (p = 0.003) and there were strong trends toward longer than normal small intestinal transit time (HS: median 4.9 h [range 3.4-8.3 h] vs severe UC patients: median 5.9 h [range 3.9-11.9 h]; p = 0.053) and colorectal transit times (HS: median 18.2 h [range 1.5-43.7] vs severe UC patients: median 34.9 h [range 0.4-90.9 h]; p = 0.056). Our data further indicate that total GI and colorectal transit times may be prolonged in UC during early remission.
  
  
  CONCLUSIONS
  Total GI transit times are significantly prolonged during severe UC.
authors.affiliation: Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: A M
authors.initials: AM
authors.lastname: Haase
authors.affiliation: Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Gregersen
authors.affiliation: Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: L A
authors.initials: LA
authors.lastname: Christensen
authors.affiliation: Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Agnholt
authors.affiliation: Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: J F
authors.initials: JF
authors.lastname: Dahlerup
authors.affiliation: Motilis Medica SA, Lausanne, Switzerland.
authors.forename: V
authors.initials: V
authors.lastname: Schlageter
authors.affiliation: Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Krogh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053704:Capsule Endoscopy / Q000379:methods; D003093:Colitis, Ulcerative; D005260:Female; D005762:Gastroenterology / Q000295:instrumentation / Q000379:methods; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D008875:Middle Aged; D013686:Telemetry / Q000295:instrumentation / Q000379:methods; D055815:Young Adult
keywords: capsule; gastrointestinal motility; transit times; ulcerative colitis