title: [Aging and influence of inversion of the CD4:CD8 ratio in the incidence of co-morbidities and mortality in a cohort of patients infected with human immunodeficiency virus].
abstract: OBJECTIVE
  It has been postulated that the inversion of the CD4:CD8 ratio as a hallmark of immunosenescence can be an independent factor that can herald the risk of co-morbidities. We studied the influence of aging and inversion of the CD4:CD8 ratio in the incidence of comorbidities and mortality in the cohort of Hosptital Severo Ochoa.
  
  
  METHODS
  We analyzed the differences in the incidence rates of age-adjusted morbidities and evaluated the inversion of the CD4:CD8 ratio as predictor of mortality and development of comorbidities.
  
  
  RESULTS
  Age was associated with an increased incidence rate of diabetes mellitus, fractures, COPD and non-AIDS malignancies. We found an increased incidence rate of non-AIDS clinical events (OR 2.25; 95% CI 1.025-4.94) and AIDS events (OR 3.48; 95% CI 1.58-7.64) in individuals with CD4:CD8 ratio<0.7. Moreover, patients with a CD4:CD8 ratio<0.7 ratio had a higher risk of mortality (OR 5.96; 95% CI 0.73 to 48.40).
  
  
  CONCLUSIONS
  It is important to detect and prevent non-AIDS comorbidities in the presence of a CD4:CD8 ratio<0.7.
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario Severo Ochoa, Leganés, Madrid, España. Electronic address: mcerveroj@gmail.com.
authors.forename: Miguel
authors.initials: M
authors.lastname: Cervero
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario Severo Ochoa, Leganés, Madrid, España.
authors.forename: Rafael
authors.initials: R
authors.lastname: Torres
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario Severo Ochoa, Leganés, Madrid, España.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Agud
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario Severo Ochoa, Leganés, Madrid, España.
authors.forename: Susana
authors.initials: S
authors.lastname: Pastor
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario Severo Ochoa, Leganés, Madrid, España.
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Jusdado
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000276:immunology*; D016516:CD4-CD8 Ratio; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013030:Spain / Q000453:epidemiology; D055815:Young Adult
keywords: CD4:CD8 ratio; Cociente CD4/CD8; Envejecimiento prematuro; Human immunodeficiency virus; Morbidity; Morbilidad; Premature aging; Virus de inmunodeficiencia humana