title: Phosphaturic mesenchymal tumor of the brain without tumor-induced osteomalacia in an 8-year-old girl: case report.
abstract: Phosphaturic mesenchymal tumor (mixed connective tissue variant) (PMT-MCT) are tumors that may cause tumor-induced osteomalacia and rarely appear intracranially. The authors describe the case of an 8-year-old girl who was found to have PMT-MCT with involvement of the cerebellar hemisphere and a small tumor pedicle breaching the dura mater and involving the skull. This was removed surgically in gross-total fashion without further complication. Histologically the tumor was confirmed to be a PMT-MCT. There was no evidence of tumor-induced osteomalacia. At the 42-month follow-up, the patient is doing well, has no abnormalities, and is free of recurrence. PMT-MCTs are rare tumors that may involve the brain parenchyma. A gross-total resection may be effective to cure these lesions.
authors.affiliation: Division of Neurosurgery and 
authors.forename: Mark B
authors.initials: MB
authors.lastname: Ellis
authors.affiliation: Departments of 2 Radiology.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gridley
authors.affiliation: Pediatrics, and.
authors.forename: Suresh
authors.initials: S
authors.lastname: Lal
authors.affiliation: Pathology, The University of Arizona College of Medicine-Phoenix, Maricopa Medical Center, Phoenix, Arizona.
authors.forename: Geetha R
authors.initials: GR
authors.lastname: Nair
authors.affiliation: Division of Neurosurgery and 
authors.forename: Iman
authors.initials: I
authors.lastname: Feiz-Erfan
mesh_terms: D001259:Ataxia / Q000209:etiology*; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D002528:Cerebellar Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology / Q000601:surgery*; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000032:analysis* / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D017674:Hypophosphatemia / Q000209:etiology; D007015:Hypophosphatemia, Familial / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008637:Mesenchymoma / Q000737:chemistry / Q000150:complications / Q000473:pathology / Q000601:surgery*; D010018:Osteomalacia / Q000209:etiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012888:Skull Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23
keywords: ABC = aneurysmal bone cyst; PMT-MCT = phosphaturic mesenchymal tumor (mixed connective tissue variant); RT-PCR = reverse transcriptase polymerase chain reaction; TIO = tumor-induced osteomalacia; cerebellar tumor; fibroblast growth factor 23; oncology; pediatric brain tumor; phosphaturic mesenchymal tumor