title: Asymmetric synthesis of 3,3'-pyrrolidinyl-dispirooxindoles via a one-pot organocatalytic Mannich/deprotection/aza-Michael sequence.
abstract: A highly stereoselective synthesis of functionalized 3,3'-pyrrolidinyl-dispirooxindole derivatives with three stereogenic centers, including two contiguous spiro-stereocenters, has been achieved through an organocatalytic Mannich/Boc-deprotection/aza-Michael sequence. Employing the commercially available (DHQD)2PHAL as the catalyst, the scalable reaction occurs with good yields and excellent stereoselectivities, providing a short entry into a series of 3,3'-pyrrolidinyl-dispirooxindoles of potentially medical value.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany. enders@rwth-aachen.de.
authors.forename: Kun
authors.initials: K
authors.lastname: Zhao
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany. enders@rwth-aachen.de.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhi
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany. enders@rwth-aachen.de.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Chemistry, Nanoscience Center, University of Jyvaskyla, P.O. Box. 35, FI-40014, Finland.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Puttreddy
authors.affiliation: Department of Chemistry, Nanoscience Center, University of Jyvaskyla, P.O. Box. 35, FI-40014, Finland.
authors.forename: Kari
authors.initials: K
authors.lastname: Rissanen
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany. enders@rwth-aachen.de.
authors.forename: Dieter
authors.initials: D
authors.lastname: Enders