title: ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography for Evaluating the Response to Neoadjuvant Chemotherapy in Advanced Esophageal Cancer.
abstract: OBJECTIVE
  The purpose of the present study was to improve the diagnostic precision of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) after neoadjuvant chemotherapy (NAC) in patients with advanced esophageal cancer.
  
  
  METHODS
  Thirty patients underwent FDG-PET/CT before and after NAC. The maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) were measured. Patients were divided into two pathological response groups: "responders" (grades 1b-3) or "non-responders" (grades 0-1a).
  
  
  RESULTS
  Overall, 11 patients were responders. Significant differences were present for the post-NAC SUVmax (p=0.070), %decrease in SUVmax (p=0.017), post-NAC MTV (p=0.014), and %decrease in MTV (p=0.003).
  
  
  CONCLUSIONS
  Receiver operating characteristic curve analysis showed that the %decrease in MTV of the primary tumor was the best indicator of response to NAC. We are currently striving to improve the accuracy of this assessment method.
authors.affiliation: First Department of Surgery, Dokkyo Medical University, Shimotuga-gun, Tochigi, Japan yukiko-t@dokkyomed.ac.jp.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Tani
authors.affiliation: First Department of Surgery, Dokkyo Medical University, Shimotuga-gun, Tochigi, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Nakajima
authors.affiliation: First Department of Surgery, Dokkyo Medical University, Shimotuga-gun, Tochigi, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Kikuchi
authors.affiliation: First Department of Surgery, Dokkyo Medical University, Shimotuga-gun, Tochigi, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ihara
authors.affiliation: First Department of Surgery, Dokkyo Medical University, Shimotuga-gun, Tochigi, Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Muroi
authors.affiliation: First Department of Surgery, Dokkyo Medical University, Shimotuga-gun, Tochigi, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: First Department of Surgery, Dokkyo Medical University, Shimotuga-gun, Tochigi, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Domeki
authors.affiliation: First Department of Surgery, Dokkyo Medical University, Shimotuga-gun, Tochigi, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Okamoto
authors.affiliation: First Department of Surgery, Dokkyo Medical University, Shimotuga-gun, Tochigi, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamaguchi
authors.affiliation: First Department of Surgery, Dokkyo Medical University, Shimotuga-gun, Tochigi, Japan.
authors.forename: Kinro
authors.initials: K
authors.lastname: Sasaki
authors.affiliation: First Department of Surgery, Dokkyo Medical University, Shimotuga-gun, Tochigi, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tsuchioka
authors.affiliation: PET Center, Dokkyo Medical University, Shimotuga-gun, Tochigi, Japan.
authors.forename: Setsu
authors.initials: S
authors.lastname: Sakamoto
authors.affiliation: First Department of Surgery, Dokkyo Medical University, Shimotuga-gun, Tochigi, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods*; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Esophageal cancer; metabolic tumor volume; neoadjuvant chemotherapy; positron emission tomography