title: Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems.
abstract: The synthesis of curcumin-cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic β-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate curcumin. Preliminary in vitro results showed that the resulting curcumin-CD/CNCx complexes exerted antiproliferative effect on colorectal and prostatic cancer cell lines, with IC50s lower than that of curcumin alone.
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Gautier M A
authors.initials: GMA
authors.lastname: Ndong Ntoutoume
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Robert
authors.initials: R
authors.lastname: Granet
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Mbakidi
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Brégier
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: David Y
authors.initials: DY
authors.lastname: Léger
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Chloë
authors.initials: C
authors.lastname: Fidanzi-Dugas
authors.affiliation: Université d'Artois, IUT de Béthune, 1230 rue de l'Université, 62408 Béthune Cedex, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Lequart
authors.affiliation: Université d'Artois, IUT de Béthune, 1230 rue de l'Université, 62408 Béthune Cedex, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Joly
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Liagre
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Chaleix
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France. Electronic address: vincent.sol@unilim.fr.
authors.forename: Vincent
authors.initials: V
authors.lastname: Sol
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002482:Cellulose / Q000737:chemistry*; D003474:Curcumin / Q000737:chemistry* / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry; D019073:HT29 Cells; D006801:Humans; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D047392:beta-Cyclodextrins; D002482:Cellulose; D003474:Curcumin; C031215:betadex
keywords: Cancer cells; Cellulose nanocrystals; Curcumin; Drug delivery; Nanoparticles