title: Secretory leukocyte protease inhibitor (SLPI), a multifunctional protein in the host defense response.
abstract: Secretory leukocyte protease inhibitor (SLPI), a ∼12kDa nonglycosylated cationic protein, is emerging as an important regulator of innate and adaptive immunity and as a component of tissue regenerative programs. First described as an inhibitor of serine proteases such as neutrophil elastase, this protein is increasingly recognized as a molecule that benefits the host via its anti-proteolytic, anti-microbial and immunomodulatory activities. Here, we discuss the diverse functions of SLPI. Moreover, we review several novel layers of SLPI-mediated control that protect the host from excessive/dysregulated inflammation typical of infectious, allergic and autoinflammatory diseases and that support healing responses through affecting cell proliferation, differentiation and apoptosis.
authors.affiliation: Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Majchrzak-Gorecka
authors.affiliation: Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Majewski
authors.affiliation: Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Grygier
authors.affiliation: Department of Computational Biophysics and Bioinformatics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Murzyn
authors.affiliation: Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland. Electronic address: Joanna.Cichy@uj.edu.pl.
authors.forename: Joanna
authors.initials: J
authors.lastname: Cichy
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D006801:Humans; D019272:Leukocyte Elastase / Q000276:immunology / Q000378:metabolism; D053481:Secretory Leukocyte Peptidase Inhibitor / Q000276:immunology* / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology
chemical_list: C506814:SLPI protein, human; D053481:Secretory Leukocyte Peptidase Inhibitor; D019272:Leukocyte Elastase
keywords: Allergy; Autoimmunity; Elastase; Inflammation; Protease