title: Depth selective acousto-optic flow measurement.
abstract: Optical based methods for non-invasive measurement of regional blood flow tend to incorrectly assess cerebral blood flow, due to contribution of extra-cerebral tissues to the obtained signal. We demonstrate that spectral analysis of phase-coded light signals, tagged by specific ultrasound patterns, enables differentiation of flow patterns at different depths. Validation of the model is conducted by Monte Carlo simulation. In-vitro experiments demonstrate good agreement with the simulations' results and provide a solid validation to depth discrimination ability. These results suggest that signal contamination originating from extra-cerebral tissue may be eliminated using spectral analysis of ultrasonically tagged light.
authors.affiliation: Ornim Medical Ltd, 15 Atir Yeda st. Kfar Saba, 4464312, Israel.
authors.forename: Adi
authors.initials: A
authors.lastname: Tsalach
authors.affiliation: Ornim Medical Ltd, 15 Atir Yeda st. Kfar Saba, 4464312, Israel.
authors.forename: Zeev
authors.initials: Z
authors.lastname: Schiffer
authors.affiliation: Ornim Medical Ltd, 15 Atir Yeda st. Kfar Saba, 4464312, Israel.
authors.forename: Eliahu
authors.initials: E
authors.lastname: Ratner
authors.affiliation: Ornim Medical Ltd, 15 Atir Yeda st. Kfar Saba, 4464312, Israel.
authors.forename: Ilan
authors.initials: I
authors.lastname: Breskin
authors.affiliation: Ornim Medical Ltd, 15 Atir Yeda st. Kfar Saba, 4464312, Israel.
authors.forename: Reuven
authors.initials: R
authors.lastname: Zeitak
authors.affiliation: Ornim Medical Ltd, 15 Atir Yeda st. Kfar Saba, 4464312, Israel.
authors.forename: Revital
authors.initials: R
authors.lastname: Shechter
authors.affiliation: Ornim Medical Ltd, 15 Atir Yeda st. Kfar Saba, 4464312, Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Balberg
keywords: (170.1065) Acousto-optics; (170.1470) Blood or tissue constituent monitoring; (170.3660) Light propagation in tissues; (170.4090) Modulation techniques; (170.7170) Ultrasound; (280.2490) Flow diagnostics