title: [Establishment of nude mouse model with ovarian carcinomaand the effect of Paris Phyllin VII combined with silica nano complex on the inhibition and the antioxidant ability of ovarian carcinoma in nude mice].
abstract: OBJECTIVE
  To establish the research model of ovarian carcinoma in nude mice, and to explore the effect of Paris Phyllin VII combined with silica nano complex on the inhibition and the antioxidant ability of ovarian carcinoma in nude mice.
  
  
  METHODS
  Nude mice models with ovarian carcinoma were established by axillary subcutaneous inoculation of human SKOV3/DDP resistant ovarian cancer cell 200 µl and were used in the experiment. Treating the nude mice with Paris Phyllin VII combined with silica nano complex by gavage for 15 days to observe the weight change of the nude mice, tumor inhibition effect and changes of serum antioxidant capacity.
  
  
  RESULTS
  Compared with the negative control group, tumor inhibition rate increased significantly in Paris Phyllin VII combined with silica nano complex treatment group, and was higher than that in both Paris Phyllin VII treatment only and silica nano composites treatment only group. The serum superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) level of Paris Phyllin VII combined with silica nano complex treatment group was significantly higher than that of control group, Paris Phyllin VII treatment only and silica nano composites treatment only group. The serum malonaldehyde (MDA) level of Paris Phyllin VII combined with silica nano complex treatment group was significantly lower than that of the negative control group.
  
  
  CONCLUSIONS
  Paris Phyllin VII combined with silica nano complex treatment can inhibit the ovarian carcinoma in nude mice, which may mediate by the enhancement of antioxidant capability in nude mice with ovarian cancer.
authors.affiliation: Department of Obstetrics and Gynecology, The Second of Jilin University, Changchun 130041, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Obstetrics and Gynecology, The Second of Jilin University, Changchun 130041, China.
authors.forename: Bihang
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, The Second of Jilin University, Changchun 130041, China.
authors.forename: Jialing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, The Second of Jilin University, Changchun 130041, China.
authors.forename: Ruiqi
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynecology, The Second of Jilin University, Changchun 130041, China; Email: fanlimei1971@126.com.
authors.forename: Limei
authors.initials: L
authors.lastname: Fan
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D049329:Nanostructures; D010051:Ovarian Neoplasms; D012822:Silicon Dioxide
chemical_list: D012822:Silicon Dioxide