title: ABCE1 plays an essential role in lung cancer progression and metastasis.
abstract: ATP-binding cassette E1 (ABCE1) is a member of the ATP-binding cassette transporters and regulates a broad range of biological functions including viral infection, cell proliferation, and anti-apoptosis. We have previously shown that ABCE1 is a prognostic indicator for lung cancer, although the underlying mechanisms remain unclear. To investigate whether the ABCE1 gene contributes to the malignancy of lung tumors, we introduced ABCE1 into LTEP-a-2 lung adenocarcinoma cells. Ectopic ABCE1 expression promoted clonogenicity and anchorage-independent growth of LTEP-a-2 cells, while in a mouse xenograft tumor model, it had an augmentative effect on tumor growth and metastasis and reduced the expression of the tumor-suppressor gene growth arrest and DNA damage-inducible 45α (GADD45α). Moreover, apoptosis was not significantly influenced by ABCE1 in vitro. In summary, we have provided evidence that ABCE1 plays an essential role in the progression and metastasis of lung cancers and may represent a valuable therapeutic target for the management of lung tumor.
authors.affiliation: Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, 4 Chongshan East Road, Shenyang, 110032, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Molecular Oncology Department of Cancer Research Institute, the First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Shenyang, 110001, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Tian
authors.affiliation: Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, 4 Chongshan East Road, Shenyang, 110032, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, 4 Chongshan East Road, Shenyang, 110032, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, 4 Chongshan East Road, Shenyang, 110032, China.
authors.forename: Cheng-Yang
authors.initials: CY
authors.lastname: Song
authors.affiliation: Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, 4 Chongshan East Road, Shenyang, 110032, China.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Jiang
authors.affiliation: Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, 4 Chongshan East Road, Shenyang, 110032, China. ono1180@163.com.
authors.forename: Da-Li
authors.initials: DL
authors.lastname: Tian
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D015153:Blotting, Western; D018797:Cell Cycle Proteins / Q000235:genetics; D045744:Cell Line, Tumor; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D064593:Heterografts; D006801:Humans; D007053:Ice; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008807:Mice, Inbred BALB C; D009362:Neoplasm Metastasis / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D000097642:GADD45 Proteins
chemical_list: D018528:ATP-Binding Cassette Transporters; D018797:Cell Cycle Proteins; D007053:Ice; D009687:Nuclear Proteins; C501918:Abce1 protein, mouse; C499072:Gadd45a protein, mouse; D000097642:GADD45 Proteins
keywords: ABCE1; Lung cancer; Metastasis; Progression