title: Identification of cCMP and cUMP Substrate Proteins and Cross Talk Between cNMPs.
abstract: cCMP and cUMP are pyrimidine cyclic nucleotides which are present in several types of cells. These molecules could exert diverse cellular functions and might act as second messengers. In the last years, diverse approaches were performed to analyze possible cellular substrates and signaling pathways of cCMP and cUMP. In this review these approaches are summarized, and probable cross talk of these signaling molecules is described. These analyses might lead to the (patho)physiological and pharmacological relevance of these noncanonical cyclic nucleotides.
authors.affiliation: Pharmacology and Toxicology, Institute of Pharmacy, University Regensburg, Universitätsstr. 31, D-93040, Regensburg, Germany. jens.schlossmann@chemie.uni-regensburg.de.
authors.forename: Jens
authors.initials: J
authors.lastname: Schlossmann
authors.affiliation: Pharmacology and Toxicology, Institute of Pharmacy, University Regensburg, Universitätsstr. 31, D-93040, Regensburg, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Wolfertstetter
mesh_terms: D000818:Animals; D001681:Biological Assay / Q000379:methods; D002478:Cells, Cultured; D003563:Cyclic CMP / Q000378:metabolism*; D006801:Humans; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D015290:Second Messenger Systems; D014542:Uridine Monophosphate / Q000378:metabolism*
chemical_list: D009712:Nucleotides, Cyclic; D003563:Cyclic CMP; C045338:cyclic 3',5'-uridine monophosphate; D014542:Uridine Monophosphate
keywords: Cross talk; Cyclic nucleotides; Kinases; Substrates; cCMP; cUMP