title: The Current Use of Mass Spectrometry in Combination with Oth er Separation Techniques in Drug Discovery Arena.
abstract: Mass spectrometry (LC-MS or LC-MS/MS) appears in all phases of drug discovery and drug development areas. Starting with the screening and identification of a therapeutic agent and further measuring its in vivo and in vitro properties include: absorption, distribution, metabolism, excretion and toxicity (ADMET) and also pharmacokinetic (PK) and pharmacodynamic (PD) quantitative parameters of drug candidate. Mass spectrometry also serves as a necessary tool also to confirm purity and stability of analyzed new chemical entities (NCEs)/new molecular entities (NMEs) as well as for the analysis of degradation products from the synthesis and following on every stages of drug discovery.
authors.affiliation: Department of Pharmaceutical Chemistry, Medical University of Gdansk, Gdansk 80-416, Poland. p99p@gumed.edu.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Kawczak
authors.forename: Tomasz
authors.initials: T
authors.lastname: Baczek
mesh_terms: D000818:Animals; D018938:Caco-2 Cells; D002853:Chromatography, Liquid / Q000379:methods*; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D010599:Pharmacokinetics; D066007:Toxicokinetics