title: [THE ROLE OF NITRIC OXIDE AND BLOOD RHEOLOGICAL PROPERTIES IN THE MAINTENANCE OF A TEMPERATURE HOMEOSTASIS IN THE BRAIN TISSUE].
abstract: The problem of temperature regulation in the brain tissue in conditions of whole body hyperthermia was investigated in experiments on white rats. The received results revealed that the brain is provided with a highly efficient system for temperature autoregulation against the changes in environmental temperature. According to our data the upper limit of this autoregulation (for rats, at least) is about the 450C of environmental temperature. The important role in functioning of this autoregulatory system belongs to Nitric Oxide. It is revealed also that the increase in the index of red cells aggregability may significantly hinder (among other things) maintaining of the temperature homeostasis in the brain.
authors.affiliation: Tbilisi State Medical University, I. Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Jojua
authors.affiliation: Tbilisi State Medical University, I. Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Gongadze
authors.affiliation: Tbilisi State Medical University, I. Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Mitagvariya
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D004567:Electrodes, Implanted; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology*; D006979:Hyperthermia, Induced / Q000379:methods; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D051381:Rats; D013238:Stereotaxic Techniques; D013696:Temperature
chemical_list: D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester