title: Association of Common Variants in LOX with Keratoconus: A Meta-Analysis.
abstract: BACKGROUND
  Several case-control studies have been performed to examine the association of genetic variants in lysyl oxidase (LOX) with keratoconus. However, the results remained inconclusive and great heterogeneity might exist across populations.
  
  
  METHODS
  A comprehensive literature search for studies that published up to June 25, 2015 was performed. Summary odds ratios (OR) and 95% confidence intervals (CI) of each single nucleotide polymorphism (SNP) were estimated with fixed effects model when I2<50% in the test for heterogeneity or random effects model when I2>50%. Publication bias was evaluated using funnel plots and Egger's test.
  
  
  RESULTS
  A total of four studies including 1,467 keratoconus cases and 4,490 controls were involved in this meta-analysis. SNPs rs2956540 and rs10519694 showed significant association with keratoconus, with ORs of 0.71 (95% CI: 0.63-0.80, P = 1.43E-08) and 0.77 (95% CI: 0.61-0.97, P = 0.026), respectively. In contrast, our study lacked sufficient evidences to support the association of rs1800449/rs2288393 with keratoconus across populations.
  
  
  CONCLUSIONS
  This meta-analysis suggested that two LOX variants, rs2956540 and rs10519694, may affect individual susceptibility to keratoconus, while distinct heterogeneity existed within this locus. Larger-scale and multi-ethnic genetic studies on keratoconus are required to further validate the results.
authors.affiliation: Research Center, Eye & ENT Hospital of Fudan University, Key Laboratory of myopia, Ministry of Health, Shanghai, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Computer Science, City University of Hong Kong, Hong Kong, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology and Visual Science, Eye & ENT Hospital of Fudan University, Key Laboratory of myopia, Ministry of Health, Shanghai, China.|Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America.
authors.forename: Jiaxu
authors.initials: J
authors.lastname: Hong
authors.affiliation: Department of Ophthalmology and Visual Science, Eye & ENT Hospital of Fudan University, Key Laboratory of myopia, Ministry of Health, Shanghai, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Ophthalmology and Visual Science, Eye & ENT Hospital of Fudan University, Key Laboratory of myopia, Ministry of Health, Shanghai, China.
authors.forename: Jianjiang
authors.initials: J
authors.lastname: Xu
mesh_terms: D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007640:Keratoconus / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D008249:Protein-Lysine 6-Oxidase / Q000235:genetics*
chemical_list: D008249:Protein-Lysine 6-Oxidase