title: [The Development of Luminescent Nano-probes on Hard X-ray Irradiation].
abstract: X-rays are widely used in imaging applications such as diffraction imaging of crystals and medical imaging. In particular, X-ray computed tomography (CT) is a critical tool for clinical and disease diagnostics. The principle of conventional CT is based on X-ray attenuation caused by photoelectric absorption and scattering. In addition to conventional CT, a number of novel methodologies are presently under development, including state-of-the-art instrument technologies and chemical probes to fulfill diagnosis criteria. Among these novel methodologies, we have utilized hard X-ray-excited optical luminescence (hXEOL) as a new methodology to enhance the contrast of the image. Herein, we explored the possibility of hXEOL via iridium-doped polymer nanoparticles and biomolecule-directed metal clusters and propose it as a potential platform for new X-ray imaging.
authors.affiliation: The Institute of Scientific and Industrial Research (ISIR), Osaka University.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Osakada
mesh_terms: D003952:Diagnostic Imaging / Q000379:methods* / Q000639:trends*; D049449:Luminescence; D053768:Metal Nanoparticles; D057054:Molecular Imaging / Q000379:methods*; D015335:Molecular Probes; D049329:Nanostructures; D012542:Scattering, Radiation; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D014965:X-Rays
chemical_list: D015335:Molecular Probes