title: Tempol protects sleep-deprivation induced behavioral deficits in aggressive male Long-Evans rats.
abstract: Earlier, we reported that elevated anxiety-like behavior and high aggression in aged retired breeder Long-Evans (L-E) rats was associated with increased plasma corticosterone and elevated oxidative stress levels. In the present study, we examined how this aged aggressive and anxious rat strain responds to acute sleep deprivation (24h) and whether their behaviors can be modulated via antioxidant tempol treatment. Four groups of L-E rats were utilized: naïve control (NC), tempol treated control (T+NC), sleep deprived (SD), tempol treated and sleep deprived (T+SD). Thus, two groups were treated with tempol (1mM in drinking water for 2 weeks) while the other two were not. Two groups were subjected to acute sleep deprivation (24h) using the columns-in-water model while the other two were not. Sleep deprivation induced anxiety-like behavior, led to significant depression-like behavior and short-term memory impairment in SD rats. And, decision-making behavior also was compromised in SD rats. These behavioral and cognitive impairments were prevented with tempol treatment in T+SD rats. Tempol treatment also reduced SD-induced increase in corticosterone and oxidative stress levels in T+SD rats. These results suggest potential involvement of oxidative stress mechanisms in regulation of sleep deprivation induced behavioral and cognitive deficits in male aged-aggressive rats.
authors.affiliation: Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX-77204, United States.
authors.forename: Naimesh
authors.initials: N
authors.lastname: Solanki
authors.affiliation: Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX-77204, United States.
authors.forename: Fatin
authors.initials: F
authors.lastname: Atrooz
authors.affiliation: Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX-77204, United States.
authors.forename: Saman
authors.initials: S
authors.lastname: Asghar
authors.affiliation: Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX-77204, United States. Electronic address: ssalim@uh.edu.
authors.forename: Samina
authors.initials: S
authors.lastname: Salim
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000375:Aging / Q000523:psychology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001007:Anxiety / Q000517:prevention & control / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood; D003497:Cyclic N-Oxides / Q000494:pharmacology* / Q000627:therapeutic use; D003863:Depression / Q000517:prevention & control / Q000523:psychology; D028421:Isoprostanes / Q000097:blood; D008297:Male; D018782:Maze Learning; D057567:Memory, Long-Term / Q000187:drug effects; D008570:Memory, Short-Term / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D020318:Rats, Long-Evans; D012892:Sleep Deprivation; D013113:Spin Labels
chemical_list: D000975:Antioxidants; D003497:Cyclic N-Oxides; D028421:Isoprostanes; D013113:Spin Labels; C001803:tempol; D003345:Corticosterone
keywords: Anxiety; Cognition; Depression and antioxidant; Stress