title: Organocatalytic and enantioselective Michael reaction between α-nitroesters and nitroalkenes. Syn/anti-selectivity control using catalysts with the same absolute backbone chirality.
abstract: The asymmetric and catalytic Michael reaction between α-nitroesters and nitroalkenes has been studied in the presence of two bifunctional catalysts both containing the same absolute chirality at the carbon backbone. The reaction performed in similar conditions allows us to control the syn or anti selectivity of the Michael adduct obtaining good yields and high enantiocontrol in all cases.
authors.affiliation: Department of Organic Chemistry II, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain.
authors.forename: Jose I
authors.initials: JI
authors.lastname: Martínez
authors.affiliation: Department of Organic Chemistry II, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain.
authors.forename: Uxue
authors.initials: U
authors.lastname: Uria
authors.affiliation: Department of Organic Chemistry II, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Muñiz
authors.affiliation: Department of Organic Chemistry II, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain.
authors.forename: Efraím
authors.initials: E
authors.lastname: Reyes
authors.affiliation: Department of Organic Chemistry II, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain.
authors.forename: Luisa
authors.initials: L
authors.lastname: Carrillo
authors.affiliation: Department of Organic Chemistry II, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain.
authors.forename: Jose L
authors.initials: JL
authors.lastname: Vicario
keywords: Michael addition; asymmetric diastereodivergent; enantioselective; nitroalkenes; nitroesters; organocatalysis; squaramides