title: Synthesis of Gold Nanoflowers Encapsulated with Poly(N-isopropylacrylamide-co-acrylic acid) Hydrogels.
abstract: In this work, hydrogel-coated gold nanoflowers (AuNFs@hydrogel) were facilely prepared. First, gold nanoflowers (AuNFs) were synthesized by reducing gold acid with ascorbic acid in the presence of chitosan biopolymers, and the chitosan-mediated AuNFs were subsequently conjugated with oleic acid with carboxylate groups. Finally, the olefin-conjugated AuNFs were encapsulated with P(NIPAM-co-AAC) hydrogels via a radical polymerization reaction with co-monomer ratio of [NIPAM:AAc = 91:9 wt%]. The encapsulated hydrogels had a lower critical solution temperature (LCST) slightly above the physiological temperature and demonstrated a thermo-sensitive variation of particle size. The hydrogel-coated AuNFs can be utilized as a promising thermo-responsive drug delivery system with a unique optical property. As-prepared samples were characterized by DLS, SEM, TEM, UV-vis and Zeta potential meter.
authors.forename: Saet-Byeol
authors.initials: SB
authors.lastname: Bae
authors.forename: Sang-Wha
authors.initials: SW
authors.lastname: Lee
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry; D001205:Ascorbic Acid / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D000178:Acrylamides; D000475:Alkenes; D020100:Hydrogels; C090629:N-isopropylacrylamide-acrylic acid copolymer; D011108:Polymers; D006046:Gold; D048271:Chitosan; D001205:Ascorbic Acid