title: Autoxidation/Aldol Tandem Reaction of 2-Oxindoles with Ketones: A Green Approach for the Synthesis of 3-Hydroxy-2-Oxindoles.
abstract: In the presence of tetrabutylammonium fluoride and molecular sieves (MS) 4 Å in DMF, an efficient autoxidation reaction of 2-oxindoles with ketones under air at room temperature has been developed. This approach may provide a green, practical, and metal-free protocol for a wide range of biologically important 3-hydroxy-3-(2-oxo-alkyl)-2-oxindoles.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P. R. China.
authors.forename: Qing-Bao
authors.initials: QB
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P. R. China.
authors.forename: Wen-Liang
authors.initials: WL
authors.lastname: Jia
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P. R. China.
authors.forename: Yong-Liang
authors.initials: YL
authors.lastname: Ban
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P. R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P. R. China. liuqiang@lzu.edu.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, P. R. China.
authors.forename: Li-Zhu
authors.initials: LZ
authors.lastname: Wu
mesh_terms: D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D010084:Oxidation-Reduction; D000078183:Oxindoles; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D007659:Ketones; D000078183:Oxindoles; D000644:Quaternary Ammonium Compounds; C022960:2-oxindole; C009405:tetrabutylammonium
keywords: C−H activation; autoxidation; oxindoles; oxygen; tetrabutylammonium fluoride