title: Plasma 8-isoPGF2α and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease.
abstract: OBJECTIVE
  F2α-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with minimal cognitive impairment (MCI) and Alzheimer-type dementia, we intended to demonstrate whether the measurement of these markers contributes to early diagnosis of Alzheimer disease (AD) in the MCI stage or not.
  
  
  METHODS
  Three groups (n = 63) were created: the AD group, MCI group, and control group. Serum melatonin levels were measured by radioimmunoassay method, and plasma total 8-isoPGF2α levels were measured by enzyme immunoassay method.
  
  
  RESULTS
  Significant differences were observed in the melatonin levels between the MCI group and AD group (P = 0.009), and in 8-isoPGF2α levels between the AD group and control group (P = 0.022). A negative correlation between mini-mental state examination (MMSE) scores and 8-isoPGF2a levels (r = -0.459, P < 0.001) and positive correlation between MMSE scores and melatonin levels (r = 0.317, P = 0.011) were found.
  
  
  CONCLUSIONS
  Although the plasma 8-isoPGF2α and serum melatonin levels in MCI were not found to be good early diagnostic markers to indicate risk of AD, results were found to support the role of oxidative stress in AD.
authors.forename: Fevziye Burcu
authors.initials: FB
authors.lastname: Sirin
authors.forename: Duygu
authors.initials: D
authors.lastname: Kumbul Doğuç
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Vural
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Eren
authors.forename: Ikbal
authors.initials: I
authors.lastname: Inanli
authors.forename: Recep
authors.initials: R
authors.lastname: Sütçü
authors.forename: Namik
authors.initials: N
authors.lastname: Delibaş
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000097:blood* / Q000175:diagnosis; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000097:blood*; D018384:Oxidative Stress
chemical_list: D015415:Biomarkers; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D008550:Melatonin