title: A Systematic Review of the Molecular Mechanisms of Uranium -Induced Reproductive Toxicity.
abstract: Uranium is the heaviest metal known as nuclear fuel, and employed in the production of glass tinting compounds, ceramic glazes, gyroscope wheels, chemical catalysts and X-ray tube targets. Inhalation and ingestion are two of the most usual ways of exposure. Uranium may be released into drinking water through the mining leading to contamination. Uranium is able to damage the DNA by generation of free radicals and acting as a catalyst in the Fenton reactions causing oxidative stress. In fact, reproductive system contains high amount of polyunsaturated fatty acids, and therefore it is highly vulnerable to reactive oxygen species (ROS) and sensitive to uranium toxicity. Toxic effects of uranium are generally reported through different mechanisms of action including inflammation, degeneration of testis, vacuolization of Leydig cells, spermatocytes necrosis, and oocyte dysmorphism. The present article provides a comprehensive review of the recent findings mostly about the molecular and biochemical toxicity of uranium on the reproductive system.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Asghari
authors.forename: Soodabeh
authors.initials: S
authors.lastname: Saeidnia
authors.forename: Mohammad Amin
authors.initials: MA
authors.lastname: Rezvanfar
authors.affiliation: Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran. Mohammad@TUMS.Ac.Ir.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
mesh_terms: D000818:Animals; D004249:DNA Damage; D005260:Female; D000075322:Heavy Metal Poisoning; D006801:Humans; D007985:Leydig Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D008297:Male; D019216:Metals, Heavy / Q000378:metabolism; D009865:Oocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D018384:Oxidative Stress / Q000187:drug effects / Q000528:radiation effects; D011041:Poisoning / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D011832:Radiation Injuries / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D012098:Reproduction / Q000187:drug effects* / Q000528:radiation effects*; D018570:Risk Assessment; D012307:Risk Factors; D014501:Uranium / Q000633:toxicity*
chemical_list: D019216:Metals, Heavy; D014501:Uranium