title: Classical and lectin complement pathway activity in polyneuropathy associated with IgM monoclonal gammopathy.
abstract: Polyneuropathy associated with IgM monoclonal gammopathy (IgM-PNP) is a slowly progressive, sensorimotor neuropathy. It is assumed that complement activation contributes to IgM-PNP pathogenesis. We investigated whether innate differences in complement activity of the classical and mannose binding lectin (MBL) pathways are associated with IgM-PNP or its severity. We measured complement activity using ELISA and determined MBL serumc oncentrations and MBL gene polymorphisms in 83 patients and 83 healthy controls. We did not observe differences between IgM-PNP patients and healthy controls nor associations with different disease severities. Differences in innate complement activity are not likely to explain susceptibility to or severity of IgM-PNP.
authors.affiliation: UMC Utrecht, Rudolf Magnus Brain Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. Electronic address: J.Stork@nki.nl.
authors.forename: Abraham C J
authors.initials: AC
authors.lastname: Stork
authors.affiliation: UMC Utrecht, Rudolf Magnus Brain Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors.forename: Elisabeth A
authors.initials: EA
authors.lastname: Cats
authors.affiliation: UMC Utrecht, Rudolf Magnus Brain Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors.forename: Lotte
authors.initials: L
authors.lastname: Vlam
authors.affiliation: UMC Utrecht, Department of Medical Microbiology, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors.forename: Erik
authors.initials: E
authors.lastname: Heezius
authors.affiliation: UMC Utrecht, Department of Medical Microbiology, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors.forename: Suzan
authors.initials: S
authors.lastname: Rooijakkers
authors.affiliation: Regional Public Health Laboratory Kennemerland, Boerhaavelaan 26, 2035 RC Haarlem, The Netherlands.
authors.forename: Bjorn
authors.initials: B
authors.lastname: Herpers
authors.affiliation: Laboratory for Medical Microbiology and Immunology, Sint Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands.
authors.forename: Ben A W
authors.initials: BA
authors.lastname: de Jong
authors.affiliation: Laboratory for Medical Microbiology and Immunology, Sint Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands.
authors.forename: Ger
authors.initials: G
authors.lastname: Rijkers
authors.affiliation: UMC Utrecht, Department of Medical Microbiology, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors.forename: Jos
authors.initials: J
authors.lastname: van Strijp
authors.affiliation: UMC Utrecht, Rudolf Magnus Brain Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors.forename: Nicolette C
authors.initials: NC
authors.lastname: Notermans
authors.affiliation: UMC Utrecht, Rudolf Magnus Brain Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors.forename: Leonard H
authors.initials: LH
authors.lastname: van den Berg
authors.affiliation: UMC Utrecht, Rudolf Magnus Brain Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors.forename: W-Ludo
authors.initials: WL
authors.lastname: van der Pol
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D015331:Cohort Studies; D003167:Complement Activation / Q000502:physiology*; D037582:Complement Pathway, Mannose-Binding Lectin / Q000502:physiology*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D011115:Polyneuropathies / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D011446:Prospective Studies
chemical_list: D001323:Autoantibodies; D007075:Immunoglobulin M
keywords: Anti-MAG neuropathy; Complement; MBL; Monoclonal gammopathy; Polyneuropathy