title: [Anesthetic effects of repeated dosing with propofol and vitamin C in mice].
abstract: OBJECTIVE
  To explore the anesthetic effects of repeated administration of propofol combined with vitamin C in mice.
  
  
  METHODS
  Forty mice were subjected to daily intraperitoneal injections of 80 mg/kg propofol (P80 group), 70 mg/kg propofol and 50 mg/kg vitamin C (P70+Vc50 group), 55 mg/kg propofol and 100 mg/kg vitamin C (P55+Vc100 group), or 50 mg/kg propofol and 200 mg/kg vitamin C (P50+Vc200 group) for 6 consecutive days, and the anesthesia induction time and anesthesia duration were recorded.
  
  
  RESULTS
  Compared with the P80 group, the mice in P55 + Vc100 group and P50 + Vc200 group showed significantly shorter anesthesia duration on the first 3 days (P<0.05). In all the groups, anesthesia duration was significantly shortened in the following days compared with that on day 1 (P<0.01); anesthesia duration was shorter on day 3 than on day 2 in P50 + Vc200 group (P<0.01), and was shorter on days 4, 5, and 6 than on day 2 in all the groups (P<0.01). In all the groups, the rate of loss of righting reflex (LORR) decreased gradually with time in a similar pattern.
  
  
  CONCLUSIONS
  Vitamin C can reduce the dose of propofol without obviously affecting the anesthetic effect to reduce the incidence of drug tolerance and potential dose-related side effects of propofol.
authors.affiliation: Anesthesia and Operation Center, General Hospital of PLA, Beijing 100853, China. E-mail: gmz_1125@163.com.
authors.forename: Mengzhuo
authors.initials: M
authors.lastname: Guo
authors.forename: Weiguang
authors.initials: W
authors.lastname: Li
authors.forename: Xu
authors.initials: X
authors.lastname: Liu
authors.forename: Zeguo
authors.initials: Z
authors.lastname: Feng
authors.forename: ChengGang
authors.initials: C
authors.lastname: Zhang
authors.forename: Fangyong
authors.initials: F
authors.lastname: Wu
authors.forename: Lianjun
authors.initials: L
authors.lastname: Huang
authors.forename: Yingqun
authors.initials: Y
authors.lastname: Yu
mesh_terms: D000758:Anesthesia; D000762:Anesthesia Recovery Period; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D004361:Drug Tolerance; D051379:Mice; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D018686:Anesthetics, Intravenous; D001205:Ascorbic Acid; D015742:Propofol