title: Assessment of dehydrothermally cross-linked collagen membrane for guided bone regeneration around peri-implant dehiscence defects: a randomized single-blinded clinical trial.
abstract: OBJECTIVE
  The aim of this study was to determine the clinical feasibility of using dehydrothermally cross-linked collagen membrane (DCM) for bone regeneration around peri-implant dehiscence defects, and compare it with non-cross-linked native collagen membrane (NCM).
  
  
  METHODS
  Dehiscence defects were investigated in twenty-eight patients. Defect width and height were measured by periodontal probe immediately following implant placement (baseline) and 16 weeks afterward. Membrane manipulation and maintenance were clinically assessed by means of the visual analogue scale score at baseline. Changes in horizontal thickness at 1 mm, 2 mm, and 3 mm below the top of the implant platform and the average bone density were assessed by cone-beam computed tomography at 16 weeks. Degradation of membrane was histologically observed in the soft tissue around the implant prior to re-entry surgery.
  
  
  RESULTS
  Five defect sites (two sites in the NCM group and three sites in the DCM group) showed soft-tissue dehiscence defects and membrane exposure during the early healing period, but there were no symptoms or signs of severe complications during the experimental postoperative period. Significant clinical and radiological improvements were found in all parameters with both types of collagen membrane. Partially resorbed membrane leaflets were only observed histologically in the DCM group.
  
  
  CONCLUSIONS
  These findings suggest that, compared with NCM, DCM has a similar clinical expediency and possesses more stable maintenance properties. Therefore, it could be used effectively in guided bone regeneration around dehiscence-type defects.
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea .
authors.forename: Jae-Hong
authors.identifier: 0000-0002-2375-0141
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea .
authors.forename: Jung-Seok
authors.identifier: 0000-0003-1276-5978
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea .
authors.forename: Won-Sun
authors.identifier: 0000-0002-3427-4101
authors.initials: WS
authors.lastname: Baek
authors.affiliation: Department of Periodontology, Kyung Hee University School of Dentistry, Seoul, Korea .
authors.forename: Hyun-Chang
authors.identifier: 0000-0001-7695-1708
authors.initials: HC
authors.lastname: Lim
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea .
authors.forename: Jae-Kook
authors.identifier: 0000-0002-6906-7209
authors.initials: JK
authors.lastname: Cha
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea .
authors.forename: Seong-Ho
authors.identifier: 0000-0001-6704-6124
authors.initials: SH
authors.lastname: Choi
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea .
authors.forename: Ui-Won
authors.identifier: 0000-0001-6371-4172
authors.initials: UW
authors.lastname: Jung
keywords: Augment bone graft; Controlled clinical trial; Cross-linking; Membrane