title: MLL2 protein is a prognostic marker for gastrointestinal diffuse large B-cell lymphoma.
abstract: Mixed linage leukemia gene 2 (MLL2) is identified as a novel mutation gene in diffuse large B cell lymphoma (DLBCL). However, the significance of MLL2 protein expression for the prognosis of DLBCL is unclear. In this study, we detected MLL2 protein expression in primary gastrointestinal diffuse large B cell lymphoma (PGI-DLBCL) samples by using tissue microarray immunohistochemistry, and analyzed the correlation between MLL2 protein expression and tumor proliferation activity. In addition, we investigated clinical significance of MLL2 protein expression for PGI-DLBCL prognosis. We found that there was significant difference in MLL2 protein expression between PGI-DLBCL and reactive hyperplasia of lymph node. High expression of MLL2 protein indicated higher clinical stage. In older patients (>60 years) with PGI-DLBCL, MLL2 protein expression was positively correlated with Ki-67 expression and negatively correlated with patient survival. Our data suggest that MLL2 protein is overexpressed in PGI-DLBCL and appears as a prognostic factor for patients of PGI-DLBCL, especially for those older than 60 years old.
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, China.
authors.forename: Haige
authors.initials: H
authors.lastname: Ye
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Ge
authors.affiliation: Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, China.
authors.forename: Shenmeng
authors.initials: S
authors.lastname: Gao
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, China.
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liang
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Yu
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, China.
authors.forename: Kaiyan
authors.initials: K
authors.lastname: Yang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D004268:DNA-Binding Proteins / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis / Q000096:biosynthesis*; D011379:Prognosis; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; C120898:KMT2D protein, human; D009363:Neoplasm Proteins
keywords: MLL2 protein; Primary gastrointestinal lymphoma; immunohistochemistry; prognosis; tissue microarray