title: A one pot, two-step synthesis of 5-arylpyrrolo[2,3-d]pyrimidines and screening of their preliminary antibacterial properties.
abstract: A one pot two step methodology for the synthesis of ten derivatives of 5-arylpyrrolo[2,3-d]pyrimidine has been reported. The methodology exploits the strong reducing nature of alkaline Na2S2O4 solution coupled with favorability of Michael type addition reaction in alkaline medium. The methodology demands attraction as it is non-catalytic, quite general for wide range of nitrostyrenes and possesses comprehensive advantages over most of the earlier methods in terms of reaction time as well as yield. The methodology enjoys additional advantage of utilizing cheaper and easily available chemicals as reagent for the purpose. Some of the synthesized compounds are found to possess remarkable activity against some of the tested bacterial strains.
authors.affiliation: Department of Chemical Sciences, Tezpur University (A Central University), Tezpur, Napaam 784028, Assam, India; Department of Chemistry, Rajiv Gandhi University (A Central University), Rono-Hills, Doimukh 791112, Arunachal Pradesh, India.
authors.forename: Lakhinath
authors.initials: L
authors.lastname: Saikia
authors.affiliation: Department of Pharmaceutical Technology, Defence Research Laboratory, Tezpur, Post Bag No. 2, Solmara 784001, Assam, India.
authors.forename: P
authors.initials: P
authors.lastname: Roudragouda
authors.affiliation: Department of Chemical Sciences, Tezpur University (A Central University), Tezpur, Napaam 784028, Assam, India. Electronic address: ashim@tezu.ernet.in.
authors.forename: Ashim J
authors.initials: AJ
authors.lastname: Thakur
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D003500:Cyclization; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D011743:Pyrimidines; D011758:Pyrroles; C450639:Pyrrolo(2,3-d)pyrimidine
keywords: Michael type addition; Na(2)S(2)O(4); NaOH; Pyrrolo[2,3-d]pyrimidine; Reductive cyclization