title: [The Effect of the Antioxidant Drug U-74389G on Magnesium Levels During Hypoxia-Reoxygenation Injury in Rats].
abstract: OBJECTIVE
  The aim of this experimental study was to examine the effect of the antioxidant drug U-74389G in a rat model of hypoxia-reoxygenation using the previously established protocol. Effects of treatments were evaluated by magnesium (Mg2+) levels in blood.
  
  
  METHODS
  Non-randomized controlled study was performed. Mg2+ levels were determined in 60 min (groups A and C) and 120 min (groups B and D) after starting the reoxygenation. Groups A and B received no drugs, whereas rats from groups C and D were administered with U-74389G.
  
  
  RESULTS
  40 rats 16-18 weeks old of a mean weight of 2312 g were employed in the study. It is demonstrated that U-74389G administration did not alter the Mg2+ levels (decrease in Mg2+ concentration was 0.28±2.75%; p=0.917). Reoxygenation non-significantly increased the Mg2+ levels by 4.27±2.66% (p=0.107). Together, the U-74389G administration and reoxygenation non-significantly increased the Mg2+ levels by 0.36±1.64% (p=0.823).
  
  
  CONCLUSIONS
  U-74389G administration, alone or in concert with reoxygenation did not significantly affect Mg2+ level in blood after experimental hypoxia in rats.
authors.forename: C
authors.initials: C
authors.lastname: Tsompos
authors.forename: C
authors.initials: C
authors.lastname: Panoulis
authors.forename: K
authors.initials: K
authors.lastname: Toutouzas
authors.forename: G
authors.initials: G
authors.lastname: Zografos
authors.forename: A
authors.initials: A
authors.lastname: Papalois
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D000860:Hypoxia / Q000097:blood / Q000188:drug therapy*; D008274:Magnesium / Q000097:blood*; D011281:Pregnatrienes / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000097:blood / Q000188:drug therapy*
chemical_list: D000975:Antioxidants; D011281:Pregnatrienes; C074965:U 74389F; D008274:Magnesium