title: Rs5918ITGB3 Polymorphism, Smoking, and BMI as Risk Factors for Early Onset and Recurrence of DVT in Young Women.
abstract: OBJECTIVE
  To evaluate the contribution of rs5918ITGB3 on the incidence and recurrence of deep venous thrombosis (DVT) in women and the relationship with body mass index (BMI) and smoking and to compare with data in men.
  
  
  RESULTS
  Rs5918(C) polymorphism in ITGB3 gene was assessed in 224 patients diagnosed with DVT and 216 controls. Thrombophilic genetic variant rs5918(C) was significantly pronounced in women (χ2=7.565, P = .008) and total patients (χ2= 9.266, P = .002) but not in men. Women patients (<45 years) who were carriers of rs5918ITGB3 polymorphism had an early onset of DVT (34.5 vs 39.4 years, χ2= 7.027, P = .008) as analyzed by Kaplan-Meier and a higher risk of the recurrent event (χ2= 3.405, odds ratio = 2.581, P = .044). The period before recurrent venous thromboembolism event was related to smoking status and BMI in young female who were carriers of rs5918 polymorphism but not in the males.
  
  
  CONCLUSIONS
  Carriage of genetic variant rs5918(C) polymorphism in ITGB3 gene in women contributes to higher risk of single and recurrent DVT events at younger age.
authors.affiliation: 1 Department of Biochemistry, Medical University-Pleven, Pleven, Bulgaria.
authors.forename: Regina
authors.initials: R
authors.lastname: Komsa-Penkova
authors.affiliation: 1 Department of Biochemistry, Medical University-Pleven, Pleven, Bulgaria.
authors.forename: Georgi
authors.initials: G
authors.lastname: Golemanov
authors.affiliation: 2 Department of Surgery, University Hospital, Medical University-Pleven, Pleven, Bulgaria.
authors.forename: Boris
authors.initials: B
authors.lastname: Tsankov
authors.affiliation: 1 Department of Biochemistry, Medical University-Pleven, Pleven, Bulgaria.
authors.forename: Petar
authors.initials: P
authors.lastname: Ivanov
authors.affiliation: 2 Department of Surgery, University Hospital, Medical University-Pleven, Pleven, Bulgaria.
authors.forename: Lyubomir
authors.initials: L
authors.lastname: Beshev
authors.affiliation: 2 Department of Surgery, University Hospital, Medical University-Pleven, Pleven, Bulgaria.
authors.forename: Pencho
authors.initials: P
authors.lastname: Tonchev
mesh_terms: D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D005260:Female; D006801:Humans; D015994:Incidence; D039661:Integrin beta3 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012008:Recurrence; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking; D020246:Venous Thrombosis / Q000209:etiology*
chemical_list: C061248:ITGB3 protein, human; D039661:Integrin beta3
keywords: DVT; early onset; glycoprotein IIb/IIIa/integrin B3; recurrence; rs5918(C)/PlA1A2