title: Functional-structural reorganisation of the neuronal network for auditory perception in subjects with unilateral hearing loss: Review of neuroimaging studies.
abstract: OBJECTIVE
  This paper aims to provide a review of studies using neuroimaging to measure functional-structural reorganisation of the neuronal network for auditory perception after unilateral hearing loss.
  
  
  METHODS
  A literature search was performed in PubMed. Search criterions were peer reviewed original research papers in English completed by the 11th of March 2015.
  
  
  METHODS
  Twelve studies were found to use neuroimaging in subjects with unilateral hearing loss. An additional five papers not identified by the literature search were provided by a reviewer. Thus, a total of 17 studies were included in the review.
  
  
  RESULTS
  Four different neuroimaging methods were used in these studies: Functional magnetic resonance imaging (fMRI) (n = 11), diffusion tensor imaging (DTI) (n = 4), T1/T2 volumetric images (n = 2), magnetic resonance spectroscopy (MRS) (n = 1). One study utilized two imaging methods (fMRI and T1 volumetric images).
  
  
  CONCLUSIONS
  Neuroimaging techniques could provide valuable information regarding the effects of unilateral hearing loss on both auditory and non-auditory performance. fMRI-studies showing a bilateral BOLD-response in patients with unilateral hearing loss have not yet been followed by DTI studies confirming their microstructural correlates. In addition, the review shows that an auditory modality-specific deficit could affect multi-modal brain regions and their connections.
authors.affiliation: Department of Clinical Medicine, Faculty of Medicine and Dentistry, University of Bergen, Jonas Lies Vei 87, 5021 Bergen, Norway; Department of Otolaryngology/Head and Neck Surgery, Haukeland University Hospital, PB 1400, 5021 Bergen, Norway. Electronic address: peder.heggdal@helse-bergen.no.
authors.forename: Peder O Laugen
authors.initials: POL
authors.lastname: Heggdal
authors.affiliation: Department of Clinical Science, Section of Logopedics, Phoniatrics and Audiology, Lund University, Box 117, 221 00 Lund, Sweden. Electronic address: jonas.brannstrom@med.lu.se.
authors.forename: Jonas
authors.initials: J
authors.lastname: Brännström
authors.affiliation: Department of Clinical Medicine, Faculty of Medicine and Dentistry, University of Bergen, Jonas Lies Vei 87, 5021 Bergen, Norway; Department of Otolaryngology/Head and Neck Surgery, Haukeland University Hospital, PB 1400, 5021 Bergen, Norway. Electronic address: hans.jorgen.aarstad@helse-bergen.no.
authors.forename: Hans Jørgen
authors.initials: HJ
authors.lastname: Aarstad
authors.affiliation: Department of Clinical Medicine, Faculty of Medicine and Dentistry, University of Bergen, Jonas Lies Vei 87, 5021 Bergen, Norway; Department of Otolaryngology/Head and Neck Surgery, Haukeland University Hospital, PB 1400, 5021 Bergen, Norway. Electronic address: flemming.slinning.vassbotn@helse-bergen.no.
authors.forename: Flemming S
authors.initials: FS
authors.lastname: Vassbotn
authors.affiliation: Department of Biological and Medical Psychology, University of Bergen, PB 7807, 5020 Bergen, Norway; Department of Clinical Engineering, Haukeland University Hospital, PB 1400, 5021 Bergen, Norway. Electronic address: karsten.specht@uib.no.
authors.forename: Karsten
authors.initials: K
authors.lastname: Specht
mesh_terms: D000161:Acoustic Stimulation; D000222:Adaptation, Physiological; D001307:Auditory Perception; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods*; D056324:Diffusion Tensor Imaging; D059907:Functional Neuroimaging; D046088:Hearing Loss, Unilateral / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009415:Nerve Net / Q000000981:diagnostic imaging* / Q000503:physiopathology; D009473:Neuronal Plasticity; D011237:Predictive Value of Tests
keywords: DTI; Neuroimaging; Plasticity; Single-sided deafness; Unilateral hearing loss; fMRI