title: Levels of hepatocyte growth factor in serum correlate with quality of life in hemodialysis patients.
abstract: OBJECTIVE
  Patients with end stage renal failure (ESRD) report low quality of life and inflammation may be one of the contributing factors. We studied if the hemodialysis induced inflammation correlates with the patients quality of life.
  
  
  METHODS
  Study was performed in 76 (35 males and 41 females) ESRD patients treated with hemodialysis. Effect of one dialysis session on blood concentration of Vascular Endothelial Growth Factor (VEGF), Hepatocyte Growth Factor (HGF), Interleukin 6 (IL6) and Monocyte Chemoattractant Protein-1 (MCP-1) was studied. Results were correlated with answers given by patients to a short questionnaire composed of questions from Kidney Disease Quality of Life Short Form (KDQoL-SF) questionnaire.
  
  
  RESULTS
  Hemodialysis induced increase of serum level of HGF (+117%) and IL-6 (+17%). Declared by patients health status correlated with their age, GFR, kt/V and hemodialysis induced change in serum IL6 and HGF level (R(2) = 0469, P < 0.001). Physical activity correlated with age, serum IL-6 and hemodialysis induced change in serum HGF and VEGF (R(2) = 0.362, P < 0.001). Presence of social/mental problems during previous 4 weeks correlated with age, serum HGF and hemodialysis induced changes in serum HGF and VEGF levels (R(2) = 0.333, P < 0.001). Interference of the kidney disease with daily life activities correlated with age, serum VEGF and hemodialysis induced change in serum HGF and IL6 levels (R(2) = 0.422, P < 0.001).
  
  
  CONCLUSIONS
  Inflammation correlates with reduced quality of life in ESRD. Low hemodialysis-induced release of the anti-inflammatory cytokine HGF correlates with impaired quality of life in that group of patients.
authors.affiliation: Department of Pathophysiology, PUMS Poland ; Department of Philosophy of Medicine and Bioethics, PUMS Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Baum
authors.affiliation: Department of Pathophysiology, PUMS Poland ; Department of Nephrology, PUMS Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Pawlaczyk
authors.affiliation: Department of Pathophysiology, PUMS Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Maćkowiak
authors.affiliation: Department of Pathophysiology, PUMS Poland.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Sosinska
authors.affiliation: Department of Pathophysiology, PUMS Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Matecka
authors.affiliation: Department of Pathophysiology, PUMS Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Kolodziejczak
authors.affiliation: Department of Pathophysiology, PUMS Poland ; Department of Philosophy of Medicine and Bioethics, PUMS Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Musielak
authors.affiliation: Department of Pathophysiology, PUMS Poland ; Higher Vocational State School Kalisz, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Breborowicz
mesh_terms: D000328:Adult; D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000209:etiology*; D015850:Interleukin-6 / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D006435:Renal Dialysis / Q000009:adverse effects*; D011795:Surveys and Questionnaires; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: C066855:HGF protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D017228:Hepatocyte Growth Factor
keywords: Uremia-hemodialysis; hepatocyte growth factor; inflammation; quality of life