title: Methicillin-susceptible strains responsible for postoperative orthopedic infection are not selected by the use of cefazolin in prophylaxis.
abstract: Comparison of methicillin-susceptible Staphylococcus aureus (MSSA) isolates responsible for bone and joint infection (BJI, n=73) and nasal colonization (n=57) revealed similar prevalence of β-lactamase (blaZ) type A production, associated with cefazolin hydrolysis, suggesting that blaZ type A-carrying MSSA isolates implicated in postoperative BJI are not selected by cefazolin prophylaxis.
authors.affiliation: Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Lyon, France; Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France. Electronic address: sophie.assant@chu-lyon.fr.
authors.forename: Sophie
authors.initials: S
authors.lastname: Trouillet-Assant
authors.affiliation: Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Lyon, France; Infectious Diseases Department, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Valour
authors.affiliation: Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Lyon, France; Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France.
authors.forename: William
authors.initials: W
authors.lastname: Mouton
authors.affiliation: Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Lyon, France; Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Martins-Simões
authors.affiliation: Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Lyon, France; Orthopedic Surgery Department, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lustig
authors.affiliation: Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Lyon, France; Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Laurent
authors.affiliation: Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Lyon, France; Infectious Diseases Department, Northern Hospital Group, Hospices Civils de Lyon, Lyon, France.
authors.forename: Tristan
authors.initials: T
authors.lastname: Ferry
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001170:Arthritis, Infectious / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology* / Q000517:prevention & control; D001850:Bone Diseases, Infectious / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D002437:Cefazolin / Q000627:therapeutic use*; D006801:Humans; D016106:Methicillin Resistance; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D019637:Orthopedic Procedures / Q000009:adverse effects*; D011183:Postoperative Complications
chemical_list: D000900:Anti-Bacterial Agents; D002437:Cefazolin
keywords: Bone and joint infection; Cefazolin; Prophylaxis; Staphylococcus aureus; β-Lactamase