title: Bromotyrosine-derived metabolites from an Indonesian marine sponge in the family Aplysinellidae (Order Verongiida).
abstract: Seven new bromotyrosine-derived metabolites, purpuramine M-N (1-2), araplysillin VII-XI (3-7) and six known compounds (8-13) were isolated from an Indonesian sponge belonging to the family Aplysinellidae (Order Verongiida). The structures of the new compounds were determined by extensive NMR experiments and mass spectrometric measurements. These compounds were screened against BACE1 and five cancer cell lines.
authors.affiliation: Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, United States.
authors.forename: Jingqiu
authors.initials: J
authors.lastname: Dai
authors.affiliation: Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, United States.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Parrish
authors.affiliation: Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, United States.
authors.forename: Wesley Y
authors.initials: WY
authors.lastname: Yoshida
authors.affiliation: University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, United States.
authors.forename: M L Richard
authors.initials: MLR
authors.lastname: Yip
authors.affiliation: University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, United States.
authors.forename: James
authors.initials: J
authors.lastname: Turkson
authors.affiliation: Coasts and Oceans National Centre, National Institute of Water and Atmospheric Research, Auckland, New Zealand.
authors.forename: Michelle
authors.initials: M
authors.lastname: Kelly
authors.affiliation: Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, United States; University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, United States. Electronic address: philipwi@hawaii.edu.
authors.forename: Philip
authors.initials: P
authors.lastname: Williams
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007555:Isoxazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D041681:NIH 3T3 Cells; D010091:Oximes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D011480:Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D007555:Isoxazoles; D010091:Oximes; D011480:Protease Inhibitors; D014443:Tyrosine; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases
keywords: Aplysinellidae; BACE1 inhibitors; Bromotyrosine-derivatives; Cell viability; Verongiida