title: Evaluation of chitosan quaternary ammonium salt-modified resin denture base material.
abstract: Chitosan quaternary ammonium salt displays good antioxidant and antibacterial characteristics and it shows appreciable solubility in water. When added to the traditional denture material to form a resin base, it could promote good oral health by improving the oral environment. In this study, chitosan quaternary ammonium salt was added to the denture material following two different methods. After three months of immersion in artificial saliva, the specimens were tested for tensile strength and were scanned by electron microscope. The murine fibroblast cytotoxicity and antibacterial properties were also tested. The result showed no significant differences in the tensile strength and in the proliferation of murine L929 fibroblast cells. The two structures of chitosan quaternary ammonium salt-modified denture material had different degrees of corrosion resistance and antimicrobial properties. These results indicate that chitosan quaternary ammonium salt-modified resin denture base material has the potential to become a new generation oral denture composite material.
authors.affiliation: Prosthodontics of Harbin Medical University Stomatology Hospital, Harbin Medical University, No. 143 Yiman Street, Nangang District, Harbin 150001, China. Electronic address: songrong1977@126.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Song
authors.affiliation: Department of Pathogenic Microbiology, School of Basic Medical Sciences, Harbin Medical University, No. 157 Baojian Street, Nangang District, Harbin 150081, China.
authors.forename: Zhaohua
authors.initials: Z
authors.lastname: Zhong
authors.affiliation: Department of Pathogenic Microbiology, School of Basic Medical Sciences, Harbin Medical University, No. 157 Baojian Street, Nangang District, Harbin 150081, China.
authors.forename: Lexun
authors.initials: L
authors.lastname: Lin
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival; D048271:Chitosan / Q000737:chemistry*; D003819:Denture Bases; D005347:Fibroblasts; D008422:Materials Testing; D051379:Mice; D008826:Microbial Sensitivity Tests; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012117:Resins, Synthetic / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013291:Streptococcus / Q000187:drug effects; D013499:Surface Properties
chemical_list: D000890:Anti-Infective Agents; D000644:Quaternary Ammonium Compounds; D012117:Resins, Synthetic; D048271:Chitosan
keywords: Antibacterial; Chitosan quaternary ammonium salt; Resin denture base