title: Optimal cutoff points for HOMA-IR and QUICKI in the diagnosis of metabolic syndrome and non-alcoholic fatty liver disease: A population based study.
abstract: OBJECTIVE
  The present study was carried out to determine the optimal cutoff points for homeostatic model assessment (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) in the diagnosis of metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD).
  
  
  METHODS
  The baseline data of 5511 subjects aged ≥18years of a cohort study in northern Iran were utilized to analyze. Receiver operating characteristic (ROC) analysis was conducted to determine the discriminatory capability of HOMA-IR and QUICKI in the diagnosis of MetS and NAFLD. Youden index was utilized to determine the optimal cutoff points of HOMA-IR and QUICKI in the diagnosis of MetS and NAFLD.
  
  
  RESULTS
  The optimal cutoff points for HOMA-IR in the diagnosis of MetS and NAFLD were 2.0 [sensitivity=64.4%, specificity=66.8%] and 1.79 [sensitivity=66.2%, specificity=62.2%] in men and were 2.5 [sensitivity=57.6%, specificity=67.9%] and 1.95 [sensitivity=65.1%, specificity=54.7%] in women respectively. Furthermore, the optimal cutoff points for QUICKI in the diagnosis of MetS and NAFLD were 0.343 [sensitivity=63.7%, specificity=67.8%] and 0.347 [sensitivity=62.9%, specificity=65.0%] in men and were 0.331 [sensitivity=55.7%, specificity=70.7%] and 0.333 [sensitivity=53.2%, specificity=67.7%] in women respectively.
  
  
  CONCLUSIONS
  Not only the optimal cutoff points of HOMA-IR and QUICKI were different for MetS and NAFLD, but also different cutoff points were obtained for men and women for each of these two conditions.
authors.affiliation: Department of Social Medicine, Zanjan University of Medical Sciences, Gavazang Road, Zanjan, Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Motamed
authors.affiliation: Department of Cardiology, Hazrat Rasoul Hospital, Iran University of Medical Sciences, Niayesh St. Satarkhan Ave., 1445613131, Tehran, Iran.
authors.forename: Seyed Javad Haji
authors.initials: SJ
authors.lastname: Miresmail
authors.affiliation: Gastroenterology and Liver Disease Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Beh Afarin St., Karim Khan Zand Ave., 15900, Tehran, Iran.
authors.forename: Behnam
authors.initials: B
authors.lastname: Rabiee
authors.affiliation: Department of Virology, Tehran University of Medical Sciences, Poursina St, 16 Azar Ave, Keshavarz BLVD, Tehran, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Keyvani
authors.affiliation: Gastroenterology and Liver Disease Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Beh Afarin St., Karim Khan Zand Ave., 15900, Tehran, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Farahani
authors.affiliation: Gastroenterology and Liver Disease Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Beh Afarin St., Karim Khan Zand Ave., 15900, Tehran, Iran.
authors.forename: Mansooreh
authors.initials: M
authors.lastname: Maadi
authors.affiliation: Gastroenterology and Liver Disease Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Beh Afarin St., Karim Khan Zand Ave., 15900, Tehran, Iran. Electronic address: Zamani.Farhad@gmail.com.
authors.forename: Farhad
authors.initials: F
authors.lastname: Zamani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D015331:Cohort Studies; D003940:Diagnostic Techniques, Endocrine / Q000592:standards*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000378:metabolism; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis* / Q000378:metabolism; D012372:ROC Curve; D012016:Reference Values; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Diagnostic index; Homeostatic model assessment index; Metabolic syndrome; Non-alcoholic fatty liver disease; Quantitative insulin sensitivity check index