title: Quantitative Imaging Analysis of FDG PET/CT Imaging for Detection of Central Neurolymphomatosis in a Case of Recurrent Diffuse B-Cell Lymphoma.
abstract: Neurolymphomatosis (NL) is a rare disease characterized by malignant lymphocytes infiltrating various structures of the nervous system. It typically manifests as a neuropathy involving the peripheral nerves, nerve roots, plexuses, or cranial nerves. It often presents as a complication of lymphoma, but it can be the presenting feature of recurrent lymphoma. It is essential to identify and initiate treatment early with chemotherapy and/or radiation therapy in all cases of nodal or visceral (including neural) involvement with lymphoma. There are various diagnostic tests that can be used for its detection, such as cerebrospinal spinal fluid (CSF) cytology, electromyography (EMG), magnetic resonance imaging (MRI), and positron-emission tomography/computed tomography (PET/CT). FDG-PET/CT is the standard of care in lymphoma staging, restaging, and therapy response assessment, but has an inherent limitation in the detection of disease involvement in the central nervous system. While that is mostly true for visual assessment, there are quantitative methods to measure variation in the metabolic activity in the brain, which in turn helps detect the occurrence of neurolymphomatosis.
authors.affiliation: Imaging Informatics, University of Pittsburgh Medical Center ; Molecular Imaging Physician, S&L Readings, LLC.
authors.forename: Faiq
authors.initials: F
authors.lastname: Shaikh
authors.affiliation: Department of Radiology, University of Iowa Hospitals and Clinics.
authors.forename: Derek
authors.initials: D
authors.lastname: Savells
authors.affiliation: Department of Radiology, Dartmouth Hitchcock Medical Center.
authors.forename: Omer
authors.initials: O
authors.lastname: Awan
authors.affiliation: Department of Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, N.Y., USA.
authors.forename: Faisal
authors.initials: F
authors.lastname: Inayat
authors.affiliation: Neuroradiology, Johns Hopkins University School of Medicine.
authors.forename: Ammar
authors.initials: A
authors.lastname: Chaudhry
authors.affiliation: Department of Neurosurgery, University of Iowa Hospitals and Clinics.
authors.forename: Nivedita
authors.initials: N
authors.lastname: Jerath
authors.affiliation: Department of Radiology, University of Iowa Hospitals and Clinics.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Graham
keywords: analysis; diffuse large b-cell lymphoma (dlbcl); fdg pet/ct; neurolymphomatosis; pneuro; quantitative