title: Naturally Occurring Major and Minor Capsid Protein Variants of Human Papillomavirus 45 (HPV45): Differential Recognition by Cross-Neutralizing Antibodies Generated by HPV Vaccines.
abstract: We investigated naturally occurring variation within the major (L1) and minor (L2) capsid proteins of human papillomavirus genotype 45 (HPV45). Pseudoviruses (PsVs) representing HPV45 sublineages A1, A2, A3, B1, and B2 exhibited comparable particle-to-infectivity ratios and morphologies but demonstrated both increased (A2, A3, and B1) and decreased (B2) sensitivities to cross-neutralization by HPV vaccine antibodies compared to that of the A1 sublineage. Mutant PsVs identified HI loop residue 357 as being critical for conferring this differential sensitivity.
authors.affiliation: Virus Reference Department, Public Health England, London, United Kingdom.
authors.forename: Anna
authors.initials: A
authors.lastname: Godi
authors.affiliation: Virus Reference Department, Public Health England, London, United Kingdom Department of Surgery and Translational Medicine, University of Milan-Bicocca, Monza, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Facchetti
authors.affiliation: Virus Reference Department, Public Health England, London, United Kingdom.
authors.forename: Sara L
authors.initials: SL
authors.lastname: Bissett
authors.affiliation: Department of Surgery and Translational Medicine, University of Milan-Bicocca, Monza, Italy.
authors.forename: Clementina
authors.initials: C
authors.lastname: Cocuzza
authors.affiliation: National Vaccine Evaluation Consortium, Public Health England, London, United Kingdom.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Miller
authors.affiliation: Virus Reference Department, Public Health England, London, United Kingdom simon.beddows@phe.gov.uk.
authors.forename: Simon
authors.initials: S
authors.lastname: Beddows
mesh_terms: D052685:Alphapapillomavirus / Q000235:genetics / Q000276:immunology*; D057134:Antibodies, Neutralizing / Q000097:blood / Q000276:immunology*; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D036022:Capsid Proteins / Q000235:genetics / Q000276:immunology*; D003429:Cross Reactions; D014644:Genetic Variation; D006801:Humans; D009500:Neutralization Tests; D053918:Papillomavirus Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D036022:Capsid Proteins; D053918:Papillomavirus Vaccines