title: Protein sorting gone wrong--VPS10P domain receptors in cardiovascular and metabolic diseases.
abstract: VPS10P domain receptors are a unique class of sorting receptors that direct intracellular transport of target proteins in neurons and that play central roles in neurodegenerative processes. Surprisingly, genome-wide association studies now implicate the very same receptors in cardiovascular and metabolic disturbances. In this review, we discuss current findings that uncovered some of the molecular mechanisms whereby sorting receptors, such as SORLA, sortilin, and SORCS1 control homeostasis in cardiovascular and metabolic tissues, and how they promote hypercholesterolemia, atherosclerosis, obesity, and diabetes, when being altered.
authors.affiliation: Max-Delbrueck-Center for Molecular Medicine, 13125 Berlin, Germany. Electronic address: vanessa.schmidt@mdc-berlin.de.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Schmidt
authors.affiliation: Max-Delbrueck-Center for Molecular Medicine, 13125 Berlin, Germany. Electronic address: willnow@mdc-berlin.de.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Willnow
mesh_terms: D002318:Cardiovascular Diseases / Q000235:genetics* / Q000378:metabolism; D055106:Genome-Wide Association Study; D006801:Humans; D008659:Metabolic Diseases / Q000235:genetics* / Q000378:metabolism; D021381:Protein Transport; D011956:Receptors, Cell Surface / Q000235:genetics*
chemical_list: D011956:Receptors, Cell Surface
keywords: Cholesterol metabolism; GWAS; Lipoprotein receptors; Mouse models; Protein sorting; Risk genes; VPS10P domain receptors