title: Detrimental or beneficial: the role of TRPM2 in ischemia/reperfusion injury.
abstract: Ischemia/reperfusion (I/R) injury is the main cause of tissue damage and dysfunction. I/R injury is characterized by Ca(2+) overload and production of reactive oxygen species (ROS), which play critical roles in the process of I/R injury to the brain, heart and kidney, but the underlying mechanisms are largely elusive. Recent evidence demonstrates that TRPM2, a Ca(2+)-permeable cationic channel and ROS sensor, is involved in I/R injury, but whether TRPM2 plays a protective or detrimental role in this process remains controversial. In this review, we discuss the recent progress in understanding the role of TRPM2 in reperfusion process after brain, heart and kidney ischemia and the potential of targeting TRPM2 for the development of therapeutic drugs to treat I/R injury.
authors.affiliation: Department of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Collaborative Innovation Center for Brain Science, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Kai-yu
authors.initials: KY
authors.lastname: Zhan
authors.affiliation: Department of Toxicology, School of Public Health, Zhejiang University, Hangzhou 310058, China.
authors.forename: Pei-lin
authors.initials: PL
authors.lastname: Yu
authors.affiliation: Department of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Collaborative Innovation Center for Brain Science, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Chun-hui
authors.initials: CH
authors.lastname: Liu
authors.affiliation: Department of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Collaborative Innovation Center for Brain Science, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Jian-hong
authors.initials: JH
authors.lastname: Luo
authors.affiliation: Department of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Collaborative Innovation Center for Brain Science, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000098:blood supply; D015428:Myocardial Reperfusion Injury / Q000378:metabolism; D015427:Reperfusion Injury / Q000378:metabolism*; D050053:TRPM Cation Channels / Q000502:physiology*
chemical_list: D050053:TRPM Cation Channels