title: Mycobacterium abscessus Complex - a Particular Challenge in the Setting of Lung Transplantation.
abstract: Mycobacterium abscessus complex is an emerging pathogen in lung transplant candidates and recipients. M. abscessus complex is widespread in the environment and can cause pulmonary, skin and soft tissue, and disseminated infection, particularly in lung transplant recipients. It is innately resistant to many antibiotics making it difficult to treat. Herein we describe the epidemiology, clinical manifestations, diagnosis and treatment of M. abscessus with an emphasis on lung transplant candidates and recipients. We also outline the areas where data are lacking and the areas where further research is urgently needed.
authors.affiliation: a Department of Infectious Diseases , Alfred Health and Monash University , Melbourne , Australia.
authors.forename: O
authors.initials: O
authors.lastname: Smibert
authors.affiliation: b Department of Allergy, Immunology and Respiratory Medicine , Alfred Health and Monash University , Melbourne , Australia.
authors.forename: G I
authors.initials: GI
authors.lastname: Snell
authors.affiliation: c Faculty of Medicine , Nursing and Health Sciences, Monash University , Clayton , Australia.
authors.forename: H
authors.initials: H
authors.lastname: Bills
authors.affiliation: b Department of Allergy, Immunology and Respiratory Medicine , Alfred Health and Monash University , Melbourne , Australia.
authors.forename: G P
authors.initials: GP
authors.lastname: Westall
authors.affiliation: a Department of Infectious Diseases , Alfred Health and Monash University , Melbourne , Australia.
authors.forename: C O
authors.initials: CO
authors.lastname: Morrissey
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004198:Disease Susceptibility; D024881:Drug Resistance, Bacterial; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D009170:Nontuberculous Mycobacteria / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Macrolides; Mycobacterium abscessus complex; Non tuberculous mycobacterium; diagnosis; infection; lung transplantation; treatment