title: Response to immunization in children born to renal transplant recipients using immunosuppressive drugs during gestation.
abstract: The use of immunosuppressive drugs can impair vaccination responses. When used during pregnancy, they may interfere with the development of the fetus's immune system. However, little is known regarding their influence on infant's response to vaccinations. Twenty-seven children born to renal transplant mothers (Tx) taking immunosuppressive drugs and 31 healthy children had the humoral immune response and reactogenicity to tetanus, Haemophilus influenzae type b (Hib) and 7 pneumococcal serotypes evaluated. The evolution of BCG vaccine scar was also registered. Antibodies were measured by ELISA. Lymphocyte immunophenotyping was performed on cord blood and at 7-8 months of age. Among Tx neonates, 82.4% had low B lymphocyte numbers at birth, and 29.4% had also low numbers of other lymphocyte subpopulations. Nevertheless, all children developed protective antibodies with similar antibody concentrations to the control group. Vaccine reactogenicity was similar in both groups and BCG healing was uneventful.
authors.affiliation: Department of Pediatrics, Federal University of São Paulo, Division of Pediatric Infectious Diseases, Rua Pedro de Toledo, 781/9° andar São Paulo 04039-032, SP, Brazil.
authors.forename: Maria Isabel Saraiva
authors.initials: MIS
authors.lastname: Dinelli
authors.affiliation: Department of Pediatrics, Federal University of São Paulo, Division of Pediatric Infectious Diseases, Rua Pedro de Toledo, 781/9° andar São Paulo 04039-032, SP, Brazil.
authors.forename: Erika
authors.initials: E
authors.lastname: Ono
authors.affiliation: Department of Pediatrics, Federal University of São Paulo, Division of Pediatric Infectious Diseases, Rua Pedro de Toledo, 781/9° andar São Paulo 04039-032, SP, Brazil.
authors.forename: Patrícia Oliveira
authors.initials: PO
authors.lastname: Viana
authors.affiliation: Department of Pediatrics, Federal University of São Paulo, Division of Pediatric Infectious Diseases, Rua Pedro de Toledo, 781/9° andar São Paulo 04039-032, SP, Brazil.
authors.forename: Fernanda Garcia
authors.initials: FG
authors.lastname: Spina
authors.affiliation: Department of Pediatrics, Federal University of São Paulo, Division of Pediatric Infectious Diseases, Rua Pedro de Toledo, 781/9° andar São Paulo 04039-032, SP, Brazil.
authors.forename: Lily Yin
authors.initials: LY
authors.lastname: Weckx
authors.affiliation: Department of Pediatrics, Federal University of São Paulo, Division of Pediatric Infectious Diseases, Rua Pedro de Toledo, 781/9° andar São Paulo 04039-032, SP, Brazil.
authors.forename: Amélia Miyashiro Nunes
authors.initials: AMN
authors.lastname: Dos Santos
authors.affiliation: Department of Pediatrics, Federal University of São Paulo, Division of Pediatric Infectious Diseases, Rua Pedro de Toledo, 781/9° andar São Paulo 04039-032, SP, Brazil. Electronic address: m.isabelmp@uol.com.br.
authors.forename: Maria Isabel de
authors.initials: MI
authors.lastname: Moraes-Pinto
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D001402:B-Lymphocytes / Q000166:cytology; D016667:Bacterial Capsules; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D018073:Haemophilus Vaccines / Q000627:therapeutic use; D006801:Humans; D056724:Immunity, Humoral; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007223:Infant; D007231:Infant, Newborn; D016030:Kidney Transplantation; D009035:Mothers; D022242:Pneumococcal Vaccines / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology; D011446:Prospective Studies; D066027:Transplant Recipients; D014611:Vaccination; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D007166:Immunosuppressive Agents; D022242:Pneumococcal Vaccines
keywords: Gestation; Immunization; Immunosuppression; Solid organ transplantation; Vaccine