title: Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells.
abstract: Previous studies have demonstrated that Homer1b/c plays an important pro-apoptotic role through classical mitochondrial apoptotic pathway. The present study was undertaken to determine the expression and functional significance of Homer1b/c in multiple myeloma (MM). We found that Homer1b/c was lowly expressed in MM cell apoptotic model induced by doxorubicin. The positive role of Homer1b/c in cell apoptosis was further confirmed by knocking down Homer1b/c. Further study confirmed that Homer1b/c was able to affect the CAM-DR via pro-apoptotic activity regulating the ability of cell adhesion. Collectively, these data indicate that Homer1b/c may represent a good candidate for pursuing clinical trial in MM.
authors.affiliation: Liyang People's Hospital, Liyang, Jiangsu 213300, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tang
authors.affiliation: Liyang People's Hospital, Liyang, Jiangsu 213300, P.R. China.
authors.forename: Hongxuan
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Liyang People's Hospital, Liyang, Jiangsu 213300, P.R. China.
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.affiliation: Liyang People's Hospital, Liyang, Jiangsu 213300, P.R. China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Fei
authors.affiliation: Liyang People's Hospital, Liyang, Jiangsu 213300, P.R. China.
authors.forename: Liqun
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Nantong University Cancer Hospital, Nantong, Jiangsu 226001, P.R. China.
authors.forename: Yuejiao
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, Jiangsu 226001, P.R. China.
authors.forename: Yunhua
authors.initials: Y
authors.lastname: He
authors.affiliation: Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, Jiangsu 226001, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, Jiangsu 226001, P.R. China.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Miao
authors.affiliation: Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, Jiangsu 226001, P.R. China.
authors.forename: Yaxun
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, Jiangsu 226001, P.R. China.
authors.forename: Yuchan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000235:genetics; D002448:Cell Adhesion / Q000235:genetics; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D000072233:Homer Scaffolding Proteins; D006801:Humans; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology
chemical_list: D002352:Carrier Proteins; D000072233:Homer Scaffolding Proteins; D004317:Doxorubicin