title: [GENE POLYMORPHISM Gln27Glu β2-ADRENERGIC RECEPTORS IN PATIENTS WITH ISCHEMIC HEART DISEASE AS A FACTOR OF DEVELOPMENT AND PROGRESSION OF OBESITY].
abstract: Currently large numbers of genetic markers that are closely linked to the development of cardiovascular diseases and obesity are identified. The aim of our study was the study of polymorphism Gln27Glu β2-adrenergic receptor gene as a possible factor in the pathogenesis of obesity in patients with coronary heart disease. We conducted a comprehensive survey of 337 patients with coronary heart disease. All patients were divided into two groups according to the presence of obesity: the first group - patients with coronary artery disease with normal body weight (n=115), the second group - patients with coronary heart disease and obesity (n=222). The control group consisted of 35 healthy people. It was established that the presence of the G allele and genotype G/G Gln27Glu β2-adrenergic receptor gene are at risk of development and progression of obesity in patients with coronary heart disease.
authors.affiliation: Kharkiv National Medical University, Department of Internal Medicine №2 and Clinical Immunology and Allergology, Ukraine.
authors.forename: O
authors.initials: O
authors.lastname: Kadykova
authors.affiliation: Kharkiv National Medical University, Department of Internal Medicine №2 and Clinical Immunology and Allergology, Ukraine.
authors.forename: P
authors.initials: P
authors.lastname: Kravchun
authors.affiliation: Kharkiv National Medical University, Department of Internal Medicine №2 and Clinical Immunology and Allergology, Ukraine.
authors.forename: N
authors.initials: N
authors.lastname: Ryndina
authors.affiliation: Kharkiv National Medical University, Department of Internal Medicine №2 and Clinical Immunology and Allergology, Ukraine.
authors.forename: T
authors.initials: T
authors.lastname: Gabisoniya
authors.affiliation: Kharkiv National Medical University, Department of Internal Medicine №2 and Clinical Immunology and Allergology, Ukraine.
authors.forename: D
authors.initials: D
authors.lastname: Molotyagin
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D015870:Gene Expression; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D009765:Obesity / Q000175:diagnosis / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*
chemical_list: D018343:Receptors, Adrenergic, beta-2