title: Genetic diversity of lactase persistence in East African populations.
abstract: BACKGROUND
  The expression of lactase which digests lactose from milk in humans is generally lost after weaning, but selected mutations influencing the promoter of the lactase gene have spread into the human populations. This is considered a classical example of gene-culture co-evolution, and several studies suggested that the lactase gene has been under strong directional evolutionary selective pressure in the past 5000 to 10,000 years.
  
  
  RESULTS
  In the present study we investigated the distribution of three gene variants leading to lactase persistence in 12 different East African populations as well as one European population. Our results show that with the exception of Copts and Nilotic populations who are fully lactose non-persistent, the majority of populations of East Africa show at least partly lactose persistence, with both ethnic and socio-economic aspects playing an important role in the distribution of genetic variants. In this study, the variants C/G-13907 and T/G-13915, which are the major variants among the nomadic Arabs in the Arabia and Beja of East Africa, showed remarkable frequencies in Sudanese populations, especially those of pastoralists, in line with the historical links and bidirectional migration of nomadic populations between Arabia and East Africa. The C/T-13910 variant, generally associated with European populations is uniquely present among the Fulani.
  
  
  CONCLUSIONS
  These data indicate that a combination of socio-economic, ethnic and evolutionary factors converged to shape the genetic structure of lactase persistence in East African populations.
authors.affiliation: Banoon ART and Cytogenetics Centre, Bahrain Defence Force Hospital, Manama, Kingdom of Bahrain. hisham.yousif@bdfmedical.org.
authors.forename: Hisham Y
authors.initials: HY
authors.lastname: Hassan
authors.affiliation: Department of Internal Medicine and Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. Anke.EM.vanErp@radboudumc.nl.
authors.forename: Anke
authors.initials: A
authors.lastname: van Erp
authors.affiliation: Department of Internal Medicine and Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. Martin.jaeger@radboudumc.nl.
authors.forename: Martin
authors.initials: M
authors.lastname: Jaeger
authors.affiliation: Sudan Medical and Scientific Research Institute, University of Medical Sciences and Technology, Khartoum, Sudan. hanantahi@gmail.com.
authors.forename: Hanan
authors.initials: H
authors.lastname: Tahir
authors.affiliation: Department of Internal Medicine and Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. Marije.Doppenberg-Oosting@radboudumc.nl.
authors.forename: Marije
authors.initials: M
authors.lastname: Oosting
authors.affiliation: Department of Internal Medicine and Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. Leo.Joosten@radboudumc.nl.
authors.forename: Leo A B
authors.initials: LA
authors.lastname: Joosten
authors.affiliation: Department of Internal Medicine (463), Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. m.netea@radboudumc.nl.
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
mesh_terms: D044383:Black People / Q000235:genetics*; D014644:Genetic Variation; D005843:Geography; D006239:Haplotypes / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D043322:Lactase / Q000235:genetics*; D008037:Linguistics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D018401:Sample Size
chemical_list: D043322:Lactase