title: A Spinal Circuit for Mechanically-Evoked Itch.
abstract: A satisfactory neurobiological understanding of itch has proved difficult to reach. Bourane et al. have now uncovered a previously unrecognized spinal circuit for mechanically-induced itch and elucidated a mechanism that keeps it in check. Dysregulation of this circuit could contribute to chronic itch, suggesting a new strategy for itch relief.
authors.affiliation: Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address: steve.davidson@uc.edu.
authors.forename: Steve
authors.initials: S
authors.lastname: Davidson
mesh_terms: D000818:Animals; D007395:Interneurons / Q000502:physiology*; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D009433:Neural Inhibition; D011537:Pruritus / Q000503:physiopathology*; D013116:Spinal Cord / Q000502:physiology*; D009435:Synaptic Transmission
keywords: Itch; mechanoreceptor; pain; scratch; spinal; touch