title: The effects of ankaferd blood stopper and microporous polysaccharide hemospheres on epidural fibrosis in rat laminectomy model.
abstract: OBJECTIVE
  To investigate whether topically administered hemostatic agents ankaferd blood stopper and microporous polysaccharide hemospheres can decrease epidural fibrosis after laminectomy in rats.
  
  
  METHODS
  Eighteen adult male Sprague-Dawley rats were equally and randomly divided into three groups. In the treatment groups, ankaferd blood stopper and microporous polysaccharide hemospheres topically administrated upon duramater surface after laminectomy. Fibroblast count, epidural fibrosis and arachnoidal involvement were evaluated and graded histopathologically.
  
  
  RESULTS
  Our data revealed that the count of fibroblasts, the grading of epidural fibrosis and arachnoideal involvement in the rats treated with microporous polysaccharide hemospheres were significantly less than the control group. Although the arachnoideal involvement in ankaferd blood stopper group were significantly less than the control group, there were no statistical differences when comparing the grading of epidural fibrosis and the fibroblasts count between the treatment groups and the control group.
  
  
  CONCLUSIONS
  The ankaferd blood stopper and microporous polysaccharide hemospheres reduced epidural fibrosis and arachnoideal involvement after laminectomy in rats.
authors.affiliation: Ministry of Health Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Rafet
authors.initials: R
authors.lastname: Özay
authors.affiliation: Department of Orthopedics and Traumatology, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.
authors.forename: Osman Yüksel
authors.initials: OY
authors.lastname: Yavuz
authors.affiliation: Ministry of Health Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet Erhan
authors.initials: ME
authors.lastname: Türkoğlu
authors.affiliation: Department of Histology and Embryology, Faculty of Veterinary Medicine, Istanbul University, Turkey.
authors.forename: Abit
authors.initials: A
authors.lastname: Aktaş
authors.affiliation: Department of Histology and Embryology, Faculty of Veterinary Medicine, Istanbul University, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Yiğit
authors.affiliation: Orthopedics and Traumatology Clinic, Emsey Hospital, Istanbul, Turkey.
authors.forename: Hacı Mustafa
authors.initials: HM
authors.lastname: Özdemir
authors.affiliation: Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Zeki
authors.initials: Z
authors.lastname: Şekerci
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001099:Arachnoid / Q000473:pathology; D004824:Epidural Space; D005347:Fibroblasts / Q000473:pathology; D005355:Fibrosis / Q000473:pathology / Q000517:prevention & control; D006490:Hemostatics / Q000008:administration & dosage*; D007796:Laminectomy / Q000009:adverse effects; D008297:Male; D023421:Models, Animal; D010936:Plant Extracts / Q000008:administration & dosage*; D011134:Polysaccharides / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000473:pathology*; D011897:Random Allocation; D017207:Rats, Sprague-Dawley
chemical_list: D006490:Hemostatics; D010936:Plant Extracts; D011134:Polysaccharides; C539751:ankaferd blood stopper