title: Clinical characteristics, treatment and ocular complications of HLA-B27-related anterior uveitis and HLA-B27-non related anterior uveitis.
abstract: BACKGROUND
  Anterior uveitis is the most common type of intraocular inflammation. Those associated to HLA-B27 represent 18 to 32% of all anterior uveitis cases.
  
  
  OBJECTIVE
  To describe clinical characteristics, systemic treatment need, and frequency and type of ocular complications in a cohort of patients diagnosed with HLAB27-related anterior uveitis and in a cohort of patients diagnosed with HLA-B27 non-related anterior uveitis. To establish if statistically significant differences between both cohorts exist.
  
  
  METHODS
  We performed a retrospective cohort study including patients with non infectious anterior uveitis related and not related to the antigen HLA-B27.
  
  
  RESULTS
  162 patients were included, 58 diagnosed with HLA-B27-related anterior uveitis (cohort HLA-B27+1) and 104 diagnosed with HLA-B27- non related anterior uveitis (cohort HLA-B27-). No statistically significant differences were found regarding clinical characteristics between both cohorts with the exception of a higher frequency of recurrences in cohort HLA-B27+ and a higher frequency of chronic uveitis in cohort HLA-B27-. No differences were found regarding systemic treatment use nor development of ocular complications.
  
  
  CONCLUSIONS
  In contrast to previous studies, we neither found higher male gender predominance in the cohort of patients with HLA-B27-related anterior uveitis, Nor did we find differences regarding average age, laterality, development of complications nor use of systemic corticosteroids.
authors.affiliation: Sección de Reumatología, Hospital Universitari Doctor Peset, Valencia, España. Electronic address: elialtea@gmail.com.
authors.forename: Elia
authors.initials: E
authors.lastname: Valls Pascual
authors.affiliation: Servicio de Oftalmología, Hospital Universitari Doctor Peset, Valencia, España.
authors.forename: Pablo
authors.initials: P
authors.lastname: Fontanilla Ortega
authors.affiliation: Sección de Reumatología, Hospital Universitari Doctor Peset, Valencia, España.
authors.forename: Elvira
authors.initials: E
authors.lastname: Vicens Bernabeu
authors.affiliation: Servicio de Oftalmología, Hospital Universitari Doctor Peset, Valencia, España.
authors.forename: Lucía
authors.initials: L
authors.lastname: Martínez-Costa
authors.affiliation: Servicio de Reumatología, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, España.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Blanco Alonso
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D015796:HLA-B27 Antigen / Q000378:metabolism*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D014606:Uveitis, Anterior / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*
chemical_list: D015415:Biomarkers; D015796:HLA-B27 Antigen; D007166:Immunosuppressive Agents
keywords: Anterior uveitis; Complicaciones oculares; HLA-B27; Ocular complications; Uveítis anterior