title: [Diffuse large B-cell lymphoma of the testis relapsed 16 years after achieving complete response].
abstract: Testicular lymphoma is a rare disease, accounting for 1-2% of non-Hodgkin lymphoma and 5-9% of all testicular tumors, and has a high relapse rate with a poor prognosis. We report a patient with testicular diffuse large B-cell lymphoma (DLBCL) who relapsed after being in remission for 16 years. He had undergone orchiectomy of the right testis and was diagnosed as having DLBCL (stage IAE) at 49 years of age. After 3 cycles of CHOP, he achieved a complete remission. Orchiectomy was performed because of a left testicular tumor, and he was again diagnosed with DLBCL at the age of 65. VH3-21 was detected in lymphoma cells at the times of both the first diagnosis and the relapse based on analysis of the variable region of the immunoglobulin heavy chain. Accordingly, the lymphoma cells at relapse were confirmed to be the same clone as that which had been documented at the first diagnosis.
authors.forename: Isao
authors.initials: I
authors.lastname: Nagasaka
authors.forename: Takeki
authors.initials: T
authors.lastname: Mitsui
authors.forename: Takuma
authors.initials: T
authors.lastname: Ishizaki
authors.forename: Hiromi
authors.initials: H
authors.lastname: Koiso
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yokohama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Saitoh
authors.forename: Junko
authors.initials: J
authors.lastname: Hirato
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Igarashi
authors.forename: Masaru
authors.initials: M
authors.lastname: Kojima
authors.forename: Norifumi
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nojima
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Murakami
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Handa
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D012008:Recurrence; D012074:Remission Induction; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors