title: Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease.
abstract: The aim of the study was to evaluate the relation between tricuspid regurgitation (TR) severity and liver stiffness (LS) in patients with TR. A total of 131 patients with various degrees of TR secondary to left-sided heart valve disease were enrolled. Severity of TR was quantitatively assessed by proximal isovelocity surface area-derived effective regurgitant orifice (ERO). Patients were divided into 2 groups: 48 with mild-moderate TR (ERO <0.4 cm(2)) and 83 with severe TR (ERO ≥0.4 cm(2)). Transient elastography was used to measure the level of LS, an established marker of liver fibrosis, with the threshold of significant LS set at ≥12.5 kPa. Patients with severe TR had a higher LS and prevalence of significant LS than those with mild-moderate TR. Furthermore, LS and significant LS independently correlated with TR-ERO, right atrial pressure and inferior vena cava (IVC) diameter. The presence of a large TR-ERO (≥0.4 cm(2)) and IVC diameter (>2.15 cm(2)) provided a high specificity of 78% for significant LS. In conclusion, the present study demonstrates that TR-ERO, right atrial pressure, and IVC diameter are important parameters associated with LS in patients with TR.
authors.affiliation: Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China; State Key Laboratory for Liver Research, Department of Medicine, The University of Hong Kong, Hong Kong, China.
authors.forename: Wai-Kay
authors.initials: WK
authors.lastname: Seto
authors.affiliation: School of Public Health, Department of Medicine, The University of Hong Kong, Hong Kong, China.
authors.forename: Lai-Ming
authors.initials: LM
authors.lastname: Ho
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China; State Key Laboratory for Liver Research, Department of Medicine, The University of Hong Kong, Hong Kong, China.
authors.forename: James
authors.initials: J
authors.lastname: Fung
authors.affiliation: Cardiac Medical Unit, Department of Medicine, Grantham Hospital, Hong Kong, China.
authors.forename: Man-Hong
authors.initials: MH
authors.lastname: Jim
authors.affiliation: Cardiac Medical Unit, Department of Medicine, Grantham Hospital, Hong Kong, China.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Yip
authors.affiliation: Cardiac Medical Unit, Department of Medicine, Grantham Hospital, Hong Kong, China.
authors.forename: Katherine
authors.initials: K
authors.lastname: Fan
authors.affiliation: Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhen
authors.affiliation: Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
authors.forename: Ju-Hua
authors.initials: JH
authors.lastname: Liu
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China; State Key Laboratory for Liver Research, Department of Medicine, The University of Hong Kong, Hong Kong, China.
authors.forename: Man-Fung
authors.initials: MF
authors.lastname: Yuen
authors.affiliation: Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
authors.forename: Chu-Pak
authors.initials: CP
authors.lastname: Lau
authors.affiliation: Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China; Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China. Electronic address: hftse@hku.hk.
authors.forename: Hung-Fat
authors.initials: HF
authors.lastname: Tse
authors.affiliation: Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China; Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China. Electronic address: khkyiu@hku.hk.
authors.forename: Kai-Hang
authors.initials: KH
authors.lastname: Yiu
mesh_terms: D000368:Aged; D018618:Echocardiography, Doppler, Color; D019560:Echocardiography, Three-Dimensional; D004548:Elasticity; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014261:Tricuspid Valve / Q000000981:diagnostic imaging*; D014262:Tricuspid Valve Insufficiency / Q000150:complications / Q000000981:diagnostic imaging*; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging*