title: Notch Signaling in Pancreatic Development.
abstract: The Notch signaling pathway plays a significant role in embryonic cell fate determination and adult tissue homeostasis. Various studies have demonstrated the deep involvement of Notch signaling in the development of the pancreas and the lateral inhibition of Notch signaling in pancreatic progenitor differentiation and maintenance. The targeted inactivation of the Notch pathway components promotes premature differentiation of the endocrine pancreas. However, there is still the contrary opinion that Notch signaling specifies the endocrine lineage. Here, we review the current knowledge of the Notch signaling pathway in pancreatic development and its crosstalk with the Wingless and INT-1 (Wnt) and fibroblast growth factor (FGF) pathways.
authors.affiliation: College of Life Science, Northeast Forestry University, Harbin 150040, China. lxy0702@126.com.|College of Life Sciences, Agriculture and Forestry, Qiqihar University, Qiqihar 161006, China. lxy0702@126.com.
authors.forename: Xu-Yan
authors.initials: XY
authors.lastname: Li
authors.affiliation: College of Life Science, Northeast Forestry University, Harbin 150040, China. makawada@163.com.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Zhai
authors.affiliation: College of Life Science, Northeast Forestry University, Harbin 150040, China. chunboteng@nefu.edu.cn.
authors.forename: Chun-Bo
authors.initials: CB
authors.lastname: Teng
mesh_terms: D000818:Animals; D005346:Fibroblast Growth Factors; D006801:Humans; D010179:Pancreas / Q000196:embryology* / Q000378:metabolism; D051880:Receptors, Notch / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D051880:Receptors, Notch; D005346:Fibroblast Growth Factors
keywords: Notch signaling; differentiation; maintenance; pancreatic progenitor