title: TRPing on the pore phenomenon: what do we know about transient receptor potential ion channel-related pore dilation up to now?
abstract: Ion channels allow for rapid ion diffusion through the plasma membrane. In some conditions, ion channels induce changes in the critical plasma membrane permeability that permit 900-Da solutes to enter cells. This process is known as the pore phenomenon. Some transient receptor potential (TRP) channel subtypes have been highlighted such as the P2X7 receptor, plasma membrane VDAC-1 channel, and pannexin hemichannels. The TRP ion channels are considered multimodal transducers that respond to several kinds of stimuli. In addition, many TRP channel subtypes are involved in physiological and pathophysiological processes such as inflammation, pain, and cancer. The TRPA1, TRPM8, and TRPV1-4 subtypes have been shown to promote large-molecular-weight solute uptake, including impermeable fluorescent dyes, QX-314 hydrophilic lidocaine derivative, gabapentin, and antineoplastic drugs. This review discusses the current knowledge of TRP-associated pores and encourages scientists to study their features and explore them as novel therapeutic tools.
authors.affiliation: Laboratory of Inflammation, Oswaldo Cruz Institute, FIOCRUZ, Av. Brasil, n° 4365, Manguinhos, CEP 21045-900, Rio de Janeiro, Brazil. leonardobraga12@gmail.com.
authors.forename: L G B
authors.initials: LG
authors.lastname: Ferreira
authors.affiliation: Laboratory of Cellular Communication, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil, n° 4365, Manguinhos, CEP 21045-900, Rio de Janeiro, Brazil.
authors.forename: R X
authors.initials: RX
authors.lastname: Faria
mesh_terms: D000818:Animals; D002463:Cell Membrane Permeability; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D017136:Ion Transport; D058446:Ligand-Gated Ion Channels / Q000378:metabolism*; D008564:Membrane Potentials; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D010146:Pain / Q000188:drug therapy / Q000378:metabolism; D050994:Voltage-Dependent Anion Channels / Q000378:metabolism*
chemical_list: D058446:Ligand-Gated Ion Channels; D009363:Neoplasm Proteins; D050994:Voltage-Dependent Anion Channels
keywords: Dye uptake; Pore dilation; TRPA1; TRPM8; TRPV1; TRPV2; TRPV3; TRPV4; Transient receptor potential ion channels