title: Scedosporium prolificans Endocarditis: Case Report and Literature Review.
abstract: Scedosporium prolificans, a hyaline filamentous fungus, is widely distributed in the environment and is currently an emerging human pathogen, especially among immunocompromised patients. However, S. prolificans endocarditis is rare. We herein report a case of S. prolificans endocarditis in a 64-year-old patient with breast cancer in complete remission for 30 years after chemotherapy and radiation treatment who was not cured. Susceptibility testing showed resistance to all antifungal drugs, except echinocandin. A review of the literature revealed 10 cases of S. prolificans endocarditis; of these, only one involved an immunocompetent host with no risk factors and only two patients survived. In order to improve the mortality rate, it is necessary to establish rapid diagnostic methods and efficient therapeutic approaches.
authors.affiliation: Department of Infectious Diseases, The University of Tokyo, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Wakabayashi
authors.forename: Shu
authors.initials: S
authors.lastname: Okugawa
authors.forename: Keita
authors.initials: K
authors.lastname: Tatsuno
authors.forename: Mahoko
authors.initials: M
authors.lastname: Ikeda
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Misawa
authors.forename: Saho
authors.initials: S
authors.lastname: Koyano
authors.forename: Eiichi
authors.initials: E
authors.lastname: Tsuji
authors.forename: Shintaro
authors.initials: S
authors.lastname: Yanagimoto
authors.forename: Shuji
authors.initials: S
authors.lastname: Hatakeyama
authors.forename: Kyoji
authors.initials: K
authors.lastname: Moriya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yotsuyanagi
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000276:immunology*; D054714:Echinocandins / Q000008:administration & dosage*; D004696:Endocarditis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008875:Middle Aged; D009181:Mycoses / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D021681:Scedosporium / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins