title: Cryogenic molecular separation system for radioactive (11)C ion acceleration.
abstract: A (11)C molecular production/separation system (CMPS) has been developed as part of an isotope separation on line system for simultaneous positron emission tomography imaging and heavy-ion cancer therapy using radioactive (11)C ion beams. In the ISOL system, (11)CH4 molecules will be produced by proton irradiation and separated from residual air impurities and impurities produced during the irradiation. The CMPS includes two cryogenic traps to separate specific molecules selectively from impurities by using vapor pressure differences among the molecular species. To investigate the fundamental performance of the CMPS, we performed separation experiments with non-radioactive (12)CH4 gases, which can simulate the chemical characteristics of (11)CH4 gases. We investigated the separation of CH4 molecules from impurities, which will be present as residual gases and are expected to be difficult to separate because the vapor pressure of air molecules is close to that of CH4. We determined the collection/separation efficiencies of the CMPS for various amounts of air impurities and found desirable operating conditions for the CMPS to be used as a molecular separation device in our ISOL system.
authors.affiliation: National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku Chiba 263-8555, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Katagiri
authors.affiliation: National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku Chiba 263-8555, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Noda
authors.affiliation: National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku Chiba 263-8555, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku Chiba 263-8555, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nagatsu
authors.affiliation: Joint Institute for Nuclear Research, Dubna 141980, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Boytsov
authors.affiliation: Joint Institute for Nuclear Research, Dubna 141980, Russia.
authors.forename: D E
authors.initials: DE
authors.lastname: Donets
authors.affiliation: Joint Institute for Nuclear Research, Dubna 141980, Russia.
authors.forename: E D
authors.initials: ED
authors.lastname: Donets
authors.affiliation: Joint Institute for Nuclear Research, Dubna 141980, Russia.
authors.forename: E E
authors.initials: EE
authors.lastname: Donets
authors.affiliation: Joint Institute for Nuclear Research, Dubna 141980, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Ramzdorf
authors.affiliation: National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku Chiba 263-8555, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakao
authors.affiliation: National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku Chiba 263-8555, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hojo
authors.affiliation: National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku Chiba 263-8555, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Wakui
authors.affiliation: National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku Chiba 263-8555, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Noda
mesh_terms: D002250:Carbon Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification*; D017357:Cyclotrons / Q000295:instrumentation*; D007477:Ions / Q000138:chemical synthesis / Q000302:isolation & purification; D007553:Isotope Labeling / Q000295:instrumentation* / Q000379:methods; D011876:Radionuclide Generators / Q000295:instrumentation*; D012034:Refrigeration / Q000295:instrumentation* / Q000379:methods
chemical_list: D002250:Carbon Radioisotopes; D007477:Ions