title: Image processing in biodosimetry: A proposal of a generic free software platform.
abstract: The scoring of chromosome aberrations is the most reliable biological method for evaluating individual exposure to ionizing radiation. However, microscopic analyses of chromosome human metaphases, generally employed to identify aberrations mainly dicentrics (chromosome with two centromeres), is a laborious task. This method is time consuming and its application in biological dosimetry would be almost impossible in case of a large scale radiation incidents. In this project, a generic software was enhanced for automatic chromosome image processing from a framework originally developed for the Framework V project Simbio, of the European Union for applications in the area of source localization from electroencephalographic signals. The platforms capability is demonstrated by a study comparing automatic segmentation strategies of chromosomes from microscopic images.
authors.forename: Matthias
authors.initials: M
authors.lastname: Dumpelmann
authors.forename: Mariel
authors.initials: M
authors.lastname: Cadena da Matta
authors.forename: Marcela Maria
authors.initials: MM
authors.lastname: Pereira de Lemos Pinto
authors.forename: Thiago
authors.initials: T
authors.lastname: de Salazar E Fernandes
authors.forename: Edvane
authors.initials: E
authors.lastname: Borges da Silva
authors.forename: Ademir
authors.initials: A
authors.lastname: Amaral
mesh_terms: D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008214:Lymphocytes; D011874:Radiometry; D012984:Software