title: Association analysis between genetic variants in interleukin genes among different populations with hyperuricemia in Xinjiang Autonomous Region.
abstract: To investigate whether functional variants of five interleukin genes (IL-1β, IL-10, IL-8, IL-18 and IL-18RAP) are associated with susceptibility to hyperuricemia among different nationalities (including Uygur, Kazak and Han populations) in the Xinjiang Autonomous Region of China. A total of 884 hyperuricemia patients and 1316 matched controls were recruited from the First Affiliated Hospital of Xinjiang Medical University in Urumqi. After genotyping of rs4073 in IL-8, rs16944 in IL-1, rs187238 in IL-18, rs1800871 in IL-10 and rs13015714 in IL-18RAP by TaqMan allele discrimination assays, an association analysis was performed using the χ(2) test as well as a genotype-phenotype analysis. For the Uygur population, IL-8 rs4073, IL-18 rs187238 and IL-18RAP rs130154 polymorphisms were all associated with hyperuricemia (P<0.001 by genotype and P=0.008, OR 0.802 by allele for IL-8; P=0.01 by genotype and P=0.006, OR 1.332 by allele for IL-18 rs187238; P=0.007 by genotype and P=0.005, OR 1.27 by allele for IL-18RAP rs130154). For the Kazak population, only IL-18 rs187238 showed statistical significance with hyperuricemia (P=0.002 by genotype and P=0.007, OR 1.823 by allele). However, no differences were found between the five SNPs and hyperuricemia among the Han population. This study demonstrated genetic polymorphisms of different interleukin genes related to hyperuricemia vary in different nationalities in the Xinjiang Autonomous Region because of different geographical environments. IL-8, IL-1RL1 and IL-18 might be involved in the development of hyperuricemia in the Uygur population, whereas only IL-18 might be involved in the Kazak population.
authors.affiliation: College of Fundamental, Xinjiang Medical University Xinjiang, China ; School of Public Health, Xinjiang Medical University Xinjiang, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Zhang
authors.affiliation: College of Fundamental, Xinjiang Medical University Xinjiang, China ; School of Public Health, Xinjiang Medical University Xinjiang, China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University Qingdao, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Fundamental, Xinjiang Medical University Xinjiang, China ; School of Public Health, Xinjiang Medical University Xinjiang, China.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Yu
authors.affiliation: School of Public Health, Xinjiang Medical University Xinjiang, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Wang
authors.affiliation: The Disease Prevention and Control Center of Tacheng Area Tacheng, Xinjiang, China.
authors.forename: He
authors.initials: H
authors.lastname: Xia
authors.affiliation: Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University Qingdao, China.
authors.forename: Changgui
authors.initials: C
authors.lastname: Li
authors.affiliation: Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University Qingdao, China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
authors.affiliation: State Key Laboratory Incubation Base of Xinjiang Major Diseases Research (2010DS890294), First Affiliated Hospital of Xinjiang Medical University Urumqi, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yao
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D002681:China; D005006:Ethnicity; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D033461:Hyperuricemia / Q000235:genetics*; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D007378:Interleukins
keywords: Hyperuricemia; interleukins; nationalities; susceptibility