title: Clinicians' Reports in Electronic Health Records Versus Patients' Concerns in Social Media: A Pilot Study of Adverse Drug Reactions of Aspirin and Atorvastatin.
abstract: BACKGROUND
  Large databases of clinician reported (e.g., allergy repositories) and patient reported (e.g., social media) adverse drug reactions (ADRs) exist; however, whether patients and clinicians report the same concerns is not clear.
  
  
  OBJECTIVE
  Our objective was to compare electronic health record data and social media data to better understand differences and similarities between clinician-reported ADRs and patients' concerns regarding aspirin and atorvastatin.
  
  
  METHODS
  This pilot study explored a large repository of electronic health record data and social media data for clinician-reported ADRs and patients concerns for two common medications: aspirin (n = 31,817 ADRs accessible in clinical data; n = 19,186 potential ADRs accessible in social media data) and atorvastatin (n = 15,047 ADRs accessible in clinical data; n = 23,408 potential ADRs accessible in social media data).
  
  
  RESULTS
  We found that the most frequently reported ADRs matched the most frequent patients' concerns. However, several less frequently reported reactions were more prevalent on social media (i.e., aspirin-induced hypoglycemia was discussed only on social media). Overall, we found a relatively strong positive and statistically significant correlation between the frequency ranking of reactions and patients' concerns for atorvastatin (Pearson's r = 0.61, p < 0.001) but not for aspirin (Pearson's r = 0.1, p = 0.69).
  
  
  CONCLUSIONS
  Future studies should develop further natural language methods for a more detailed data analysis (i.e., identifying causality and temporal aspects in the social media data).
authors.affiliation: Brigham and Women's Hospital, Boston, MA, USA. mtopaz80@gmail.com.|Harvard Medical School, Boston, MA, USA. mtopaz80@gmail.com.|, 93 Worcester st., Wellesley Gateway, Suite 2030I, Wellesley, MA, 02481, USA. mtopaz80@gmail.com.
authors.forename: Maxim
authors.initials: M
authors.lastname: Topaz
authors.affiliation: Partners HealthCare System, Wellesley, MA, USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Lai
authors.affiliation: Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Neil
authors.initials: N
authors.lastname: Dhopeshwarkar
authors.affiliation: Brigham and Women's Hospital, Boston, MA, USA.|Partners HealthCare System, Wellesley, MA, USA.
authors.forename: Diane L
authors.initials: DL
authors.lastname: Seger
authors.affiliation: Treato Ltd., Or Yehuda, Israel.
authors.forename: Roee
authors.initials: R
authors.lastname: Sa'adon
authors.affiliation: University of Colorado, Aurora, CO, USA.
authors.forename: Foster
authors.initials: F
authors.lastname: Goss
authors.affiliation: Brigham and Women's Hospital, Boston, MA, USA.|Harvard Medical School, Boston, MA, USA.
authors.forename: Ronen
authors.initials: R
authors.lastname: Rozenblum
authors.affiliation: Brigham and Women's Hospital, Boston, MA, USA.|Harvard Medical School, Boston, MA, USA.|Partners HealthCare System, Wellesley, MA, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data*; D001241:Aspirin / Q000009:adverse effects*; D000069059:Atorvastatin / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis / Q000453:epidemiology; D057286:Electronic Health Records / Q000706:statistics & numerical data*; D005076:Exanthema / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D059352:Musculoskeletal Pain / Q000139:chemically induced / Q000453:epidemiology; D010819:Physician's Role; D010865:Pilot Projects; D061108:Social Media / Q000706:statistics & numerical data*
chemical_list: D000069059:Atorvastatin; D001241:Aspirin