title: [Intra-uterine growth restriction impact on maternal serum concentration of PlGF (placental growth factor): A case control study].
abstract: OBJECTIVE
  Placental growth factor (PlGF) is a pro-angiogenic factor mainly assessed in preeclampsia in which its blood concentration is decreased. The aim of this study was to dose the blood concentration of PlGF in women with fetal intra-uterine growth restriction (IUGR) without associated preeclampsia at the time of diagnosis.
  
  
  METHODS
  Case/control study: IUGR was defined by a fetal biometry with abnormal uterine and/or umbilical doppler (n=23). This group was compared to a control group of fetuses (n=25) matched for gestational age at blood sampling for the dosage of maternal seric PlGF. Women with preeclampsia were not included.
  
  
  RESULTS
  The plasma PlGF concentration was 11pg/mL (IQR [11-42,8]) in the IUGR group vs 287pg/mL [135-439] in the control group (P<0.001) and this difference was available after adjustment for gestational age at the time of blood sampling (P<0.001). PlGF sensitivity and specificity for discrimination were respectively 87% (CI 95% [66-97]) and 88% (CI 95% [69-97]).
  
  
  CONCLUSIONS
  Maternal serum PlGF concentrations were very low in IUGR group compared with those of the control group.
authors.affiliation: Service de gynécologie-obstétrique, hôpital de la Croix-Rousse, hospices civils de Lyon, 103, Grande-Rue-de-la-Croix-Rousse, 69317 Lyon cedex 04, France.
authors.forename: A
authors.initials: A
authors.lastname: Margossian
authors.affiliation: Unité de biologie fœtomaternelle UF 34442, service maladies héréditaires du métabolisme et dépistage néonatal, centre de biologie et pathologie Est, groupement hospitalier Est, 59, boulevard Pinel, 69500 Bron, France.
authors.forename: C
authors.initials: C
authors.lastname: Boisson-Gaudin
authors.affiliation: Service de biostatistique, hospices civils de Lyon, 69003 Lyon, France; Université de Lyon, 69000 Lyon, France; Université Lyon 1, 69100 Villeurbanne, France; CNRS, UMR 5558, Laboratoire de biométrie et biologie évolutive, équipe biostatistique-santé, 69100 Villeurbanne, France.
authors.forename: F
authors.initials: F
authors.lastname: Subtil
authors.affiliation: Service de gynécologie-obstétrique, hôpital de la Croix-Rousse, hospices civils de Lyon, 103, Grande-Rue-de-la-Croix-Rousse, 69317 Lyon cedex 04, France; Université Claude-Bernard Lyon 1, U.E.R. Lyon-Est, 8, avenue Rockefeller, 69008 Lyon, France.
authors.forename: R-C
authors.initials: RC
authors.lastname: Rudigoz
authors.affiliation: Service de gynécologie-obstétrique, hôpital de la Croix-Rousse, hospices civils de Lyon, 103, Grande-Rue-de-la-Croix-Rousse, 69317 Lyon cedex 04, France; Université Claude-Bernard Lyon 1, U.E.R. Lyon-Est, 8, avenue Rockefeller, 69008 Lyon, France.
authors.forename: G
authors.initials: G
authors.lastname: Dubernard
authors.affiliation: Centre de pathologie Nord, hôpital de la Croix-Rousse, 103, Grande-Rue-de-la-Croix-Rousse, 69317 Lyon cedex 04, France.
authors.forename: F
authors.initials: F
authors.lastname: Allias
authors.affiliation: Service de gynécologie-obstétrique, hôpital de la Croix-Rousse, hospices civils de Lyon, 103, Grande-Rue-de-la-Croix-Rousse, 69317 Lyon cedex 04, France; Université Claude-Bernard Lyon 1, U.E.R. Lyon-Est, 8, avenue Rockefeller, 69008 Lyon, France; Inserm U846, Stem Cell and Brain Research Institute, 18, avenue Doyen-Lepine, 69500 Bron, France; Université de Lyon, Lyon 1, UMR-S 846, 69003 Lyon, France. Electronic address: cyril.huissoud@chu-lyon.fr.
authors.forename: C
authors.initials: C
authors.lastname: Huissoud
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D000072483:Placenta Growth Factor / Q000097:blood*; D011225:Pre-Eclampsia; D011247:Pregnancy; D012680:Sensitivity and Specificity
chemical_list: D000072483:Placenta Growth Factor
keywords: Biomarker; Diagnostic test; Intra-uterine growth restriction (IUGR); Marqueur biochimique; Placental Growth Factor (PlGF); Placental growth factor (PlGF); Retard de croissance intra-utérin (RCIU); Test diagnostique