title: [Ultrasonographic Findings of Cervical Lymphadenopathy with Infectious Mononucleosis].
abstract: OBJECTIVE
  To evaluate the high-resolution and color Doppler ultrasonographic (US) characteristics of cervical lymphadenopathy in patients with infectious mononucleosis.
  
  
  METHODS
  High-resolution and color Doppler US were performed in 30 patients aged 2 to 30 years with a total of 59 palpable enlarged cervical lymph nodes due to infectious mononucleosis. The US characteristics of the nodes including shape,echotexture,hilum,border,matting,cystic necrosis,calcification and vascular pattern were assessed. Three patients received cervical lymph nodes biopsies.
  
  
  RESULTS
  The common US findings of cervical lymphadenopathy due to infectious mononucleosis were round shape (69.5%),bilateral distribution (96.7%),matting (83.3%) [even bilateral matting (66.6%)],indistinct margin (79.7%),absence of hilum (66.1%),heterogeneous echotecture (61.0%),and central hilar vascular pattern(89.8%). In 2 patients with absence of the echoic hilum,lymph nodes biopsies showed histological features including marked effacement of the normal architecture in the medullary region accompanied by a mixed proliferation of lymphocytes and histiocytes. In all infectious mononucleosis nodes with a hilum,85.0% had heterogeneously hypo/iso-echoic hila and indistinct demarcation to the cortex. One of them underwent lymph node biopsy and histological findings showed obvious dilation of the sinus oidal lumen and proliferation of histiocytes.
  
  
  CONCLUSIONS
  Although several ultrasonographic characteristics frequently present in the nodes of infectious mononucleosis are not specific,the combination of ultrasound findings may be valuable in differential diagnosis.
authors.forename: Xian-Shui
authors.initials: XS
authors.lastname: Fu
authors.affiliation: Department of Ultrasonography,Hainan Affilitated Hospital of Chinese PLA General Hospital,Sanya,Hainan 572013,China.
authors.forename: Liu-Qiong
authors.initials: LQ
authors.lastname: Ren
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Yang
authors.forename: Ke
authors.initials: K
authors.lastname: Lü
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Chen
authors.forename: Zhen-Cai
authors.initials: ZC
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D002114:Calcinosis; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D006801:Humans; D007244:Infectious Mononucleosis; D008206:Lymphatic Diseases / Q000000981:diagnostic imaging*; D009333:Neck; D014463:Ultrasonography; D055815:Young Adult