title: Analytical linear energy transfer model including secondary particles: calculations along the central axis of the proton pencil beam.
abstract: In proton therapy, the relative biological effectiveness (RBE) depends on various types of parameters such as linear energy transfer (LET). An analytical model for LET calculation exists (Wilkens' model), but secondary particles are not included in this model. In the present study, we propose a correction factor, L sec, for Wilkens' model in order to take into account the LET contributions of certain secondary particles. This study includes secondary protons and deuterons, since the effects of these two types of particles can be described by the same RBE-LET relationship. L sec was evaluated by Monte Carlo (MC) simulations using the GATE/GEANT4 platform and was defined by the ratio of the LET d distributions of all protons and deuterons and only primary protons. This method was applied to the innovative Pencil Beam Scanning (PBS) delivery systems and L sec was evaluated along the beam axis. This correction factor indicates the high contribution of secondary particles in the entrance region, with L sec values higher than 1.6 for a 220 MeV clinical pencil beam. MC simulations showed the impact of pencil beam parameters, such as mean initial energy, spot size, and depth in water, on L sec. The variation of L sec with these different parameters was integrated in a polynomial function of the L sec factor in order to obtain a model universally applicable to all PBS delivery systems. The validity of this correction factor applied to Wilkens' model was verified along the beam axis of various pencil beams in comparison with MC simulations. A good agreement was obtained between the corrected analytical model and the MC calculations, with mean-LET deviations along the beam axis less than 0.05 keV μm(-1). These results demonstrate the efficacy of our new correction of the existing LET model in order to take into account secondary protons and deuterons along the pencil beam axis.
authors.affiliation: Institut Curie, Centre de Protonthérapie d'Orsay, France. Institut Curie, Centre de Recherche, Plateforme de Radiothérapie Expérimentale, France.
authors.forename: F
authors.initials: F
authors.lastname: Marsolat
authors.forename: L
authors.initials: L
authors.lastname: De Marzi
authors.forename: F
authors.initials: F
authors.lastname: Pouzoulet
authors.forename: A
authors.initials: A
authors.lastname: Mazal
mesh_terms: D000465:Algorithms; D006801:Humans; D018499:Linear Energy Transfer; D008962:Models, Theoretical; D009010:Monte Carlo Method; D061766:Proton Therapy / Q000379:methods*; D011522:Protons; D012062:Relative Biological Effectiveness
chemical_list: D011522:Protons