title: The Obesity Epidemic and Consequences for Rheumatoid Arthritis Care.
abstract: With the prevalence of obesity increasing dramatically worldwide over the past several decades, an increasing body of literature has examined the impact of obesity in the context of rheumatoid arthritis (RA). Epidemiologic studies suggest that obesity may be associated with a modestly increased risk for the development of RA, although these studies have shown conflicting results. Among patients with established RA, obesity has been observed to be associated with greater subjective measures of disease activity and poor treatment response, but also with a decreased risk of joint damage and lower mortality. A comprehensive evaluation of the influence of obesity on the measurement of disease, response to therapies, and long-term prognosis is critical in order to understand these observations. This review therefore focuses on recent observations, potential explanations for these findings, and implications for clinicians and investigators caring for and studying patients with RA.
authors.affiliation: Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA. michael.george@uphs.upenn.edu.
authors.forename: Michael D
authors.initials: MD
authors.lastname: George
authors.affiliation: Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA.|Philadelphia VA Medical Center, Philadelphia, PA, USA.|Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Joshua F
authors.initials: JF
authors.lastname: Baker
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D009765:Obesity / Q000150:complications* / Q000453:epidemiology*; D011379:Prognosis; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents
keywords: Adiposity; Obesity; Rheumatoid arthritis