title: Association between APOE polymorphism and metabolic syndrome in Uyghur ethnic men.
abstract: OBJECTIVE
  This study aimed to examine the association between apolipoprotein E (APOE) polymorphism and metabolic syndrome (MetS) among Uyghur ethnic men in Xinjiang, China.
  
  
  METHODS
  A total of 482 patients with MetS and 510 healthy sex-matched and age-matched controls were recruited from the Xinjiang Uyghur Autonomous Region of China. The participants were subjected to routine physical and blood biochemical tests, and APOE genotyping was performed.
  
  
  RESULTS
  The APOE ε3/3 was the predominant type, with a frequency of 71.8%, while ε2/2 was less common than ε4/4 in Uyghur males. The frequencies of the APOE2, E3 and E4 alleles in Uyghur males were 8.5%, 80.0% and 11.5%, respectively. However, the distribution of APOE genotypes was significantly different between the MetS and control groups (p<0.001). In the MetS group, the frequencies of the ε2 and ε4 alleles and the frequencies of the ε2/2, ε2/3 and ε2/4 genotypes were significantly lower than those of the control group. Those individuals without the ε2 and ε4 alleles had higher MetS prevalence than the other gene carriers, and the ORs of these individuals developing MetS were 1.5 and 1.27 compared to the gene carriers. Triglyceride, serum total cholesterol and low-density lipoprotein cholesterol levels were lower and serum high-density lipoprotein was higher in the ε2 carriers than the ε3 carriers, and the prevalence of MetS, central obesity, high blood pressure, hypercholesterolaemia and hypertriglyceridaemia was lower in the APOE2 group than in the APOE4 group. The risks of these individuals with ε4 allele carriers getting these changes were 1.327, 1.780, 1.888, 1.428 and 2.571 times greater than those of ε2 allele carriers.
  
  
  CONCLUSIONS
  APOE4 is associated with many individual components of MetS, whereas APOE2 was associated with a reduced risk of MetS at the univariate level in Uyghur ethnic men.
authors.affiliation: College of Basic Medical Science, Xinjiang Medical University, Xinjiang, China.
authors.forename: YuPing
authors.initials: Y
authors.lastname: Sun
authors.affiliation: The Fourth Affiliated Hospital, Xinjiang Medical University, Xinjiang, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Wei
authors.affiliation: Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: DanDan
authors.initials: D
authors.lastname: Yan
authors.affiliation: The Fourth Affiliated Hospital, Xinjiang Medical University, Xinjiang, China.
authors.forename: FeiLi
authors.initials: F
authors.lastname: Xu
authors.affiliation: The Key Laboratory of Metabolic Diseases, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, China.
authors.forename: XiaoJin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Basic Medical Science, Xinjiang Medical University, Xinjiang, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Zhang
authors.affiliation: College of Basic Medical Science, Xinjiang Medical University, Xinjiang, China.
authors.forename: Delixiati
authors.initials: D
authors.lastname: Yimiti
authors.affiliation: The Second Affiliated Hospital, Xinjiang Medical University, Urumqi, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Science and Technology, Xinjiang Medical University, Urumqi, China.
authors.forename: HongYan
authors.initials: H
authors.lastname: Sun
authors.affiliation: Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Hu
authors.affiliation: The Key Laboratory of Metabolic Diseases, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, China.
authors.forename: Li
authors.initials: L
authors.lastname: Luo
authors.affiliation: The Key Laboratory of Metabolic Diseases, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yao
mesh_terms: D000886:Anthropometry; D053329:Apolipoprotein E2 / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D050171:Dyslipidemias / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D015228:Hypertriglyceridemia / Q000235:genetics; D008297:Male; D024821:Metabolic Syndrome / Q000208:ethnology / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D053329:Apolipoprotein E2; D053327:Apolipoprotein E4
keywords: APOE; Gene polymorphism; Metabolic Syndrome; Uygur ethnic