title: The Effectiveness of Porcine Dermal Collagen (Permacol(®)) on Wound Healing in the Rat Model.
abstract: Porcine acellular dermal collagen (PDC), which is a biological material derived from processing porcine dermis, has already been used for urologic, gynecologic, plastic, and general surgery procedures up to now. The aim of this study is to investigate the effectiveness of PDC on wound healing as a dermal substitute in the rat model. Twenty Wistar albino rats were divided into two groups. Standard full-thickness skin defects were created on the back of the rats. In the control group (Group 1), the dressings moisturized with saline were changed daily. In the study group (Group 2), porcine dermal collagen was implanted onto each wound and fixed with 4-0 polypropylene sutures. Contraction percentages of wound areas were calculated on the third, seventh, tenth, and fourteenth days by using the planimetric program. On fourteenth day, the wound areas were excised for histopathological examination, inflammatory scoring, and evaluation of collagen deposition. The study group was superior to the control group in terms of inflammatory scoring, type I/type III collagen ratio, and wound contraction rates. Porcine dermal collagen may be used effectively and safely on full-thickness wounds as a current dermal substitute.
authors.affiliation: General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Kalin
authors.affiliation: General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Kuru
authors.affiliation: General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey ; Genel Cerrahi Klinigi, Ulucanlar, S.B. Ankara Egitim ve Arastirma Hastanesi, Ankara, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Kismet
authors.affiliation: General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Aziz Mutlu
authors.initials: AM
authors.lastname: Barlas
authors.affiliation: General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Yusuf Akif
authors.initials: YA
authors.lastname: Akgun
authors.affiliation: Pathology Department, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Hesna Muzeyyen
authors.initials: HM
authors.lastname: Astarci
authors.affiliation: Pathology Department, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Ustun
authors.affiliation: General Surgery Department, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Ertas
keywords: Dermal substitutes; Natural biological materials; Porcine dermal collagen; Wound healing