title: Role of Kv4.3 in Vibration-Induced Muscle Pain in the Rat.
abstract: We hypothesized that changes in the expression of voltage-gated potassium channel (Kv) 4.3 contribute to the mechanical hyperalgesia induced by vibration injury, in a rodent model for hand-arm vibration syndrome in humans. Here we show that the exposure of the gastrocnemius muscle to vibration injury induces muscle hyperalgesia that is accompanied by a significant downregulation of Kv4.3 in affected sensory nerve fibers in dorsal root ganglia. We additionally show that the intrathecal administration of antisense oligonucleotides for Kv4.3 messenger RNA itself induces muscle hyperalgesia in the rat. Our results suggest that attenuation in the expression of Kv4.3 may contribute to neuropathic pain in people affected by hand-arm vibration syndrome.
  
  
  CONCLUSIONS
  Our findings establish Kv4.3 as a potential molecular target for the treatment of hand-arm vibration syndrome.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, California.
authors.forename: Lindsay B
authors.initials: LB
authors.lastname: Conner
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, California.
authors.forename: Pedro
authors.initials: P
authors.lastname: Alvarez
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, California.
authors.forename: Oliver
authors.initials: O
authors.lastname: Bogen
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, California; Department of Medicine, University of California San Francisco, San Francisco, California. Electronic address: Jon.Levine@ucsf.edu.
authors.forename: Jon D
authors.initials: JD
authors.lastname: Levine
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000502:physiology*; D005727:Ganglia, Spinal / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006930:Hyperalgesia / Q000378:metabolism; D037102:Lectins / Q000378:metabolism; D008297:Male; D063806:Myalgia / Q000209:etiology* / Q000378:metabolism*; D017288:Pain Threshold / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D051672:Shal Potassium Channels / Q000235:genetics* / Q000378:metabolism*; D053675:Versicans; D014732:Vibration / Q000009:adverse effects*
chemical_list: D006023:Glycoproteins; D037102:Lectins; D012333:RNA, Messenger; D051672:Shal Potassium Channels; C508324:Vcan protein, rat; D053675:Versicans
keywords: Hand–arm vibration syndrome; isolectin B4 binding nociceptors; muscle hyperalgesia; neuropathic pain; voltage-gated potassium channels