title: New Iridoid Glycosides with Antidepressant Activity Isolated from Cyperus rotundus.
abstract: Based on bioactive screening results, two new iridoid glycosides, named rotunduside G (1) and rotunduside H (2), were isolated from the rhizomes of Cyperus rotundus, together with four known ones, negundoside (3), nishindaside (4), isooleuropein (5) and neonuezhenide (6). Their structures were elucidated on the basis of spectroscopic methods and from literature values. In mice models of despair, 1 and 2 showed significant antidepressant activity.
authors.affiliation: School of Chemistry and Chemical Engineering, Lingnan Normal University.
authors.forename: Zhong-Liu
authors.initials: ZL
authors.lastname: Zhou
authors.forename: Wen-Qing
authors.initials: WQ
authors.lastname: Yin
authors.forename: Ya-Mei
authors.initials: YM
authors.lastname: Yang
authors.forename: Chun-Hong
authors.initials: CH
authors.lastname: He
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Li
authors.forename: Cui-Ping
authors.initials: CP
authors.lastname: Zhou
authors.forename: Hong
authors.initials: H
authors.lastname: Guo
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D029786:Cyperus / Q000737:chemistry*; D019417:Hindlimb Suspension; D057889:Iridoid Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects*; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D057889:Iridoid Glycosides