title: Total Syntheses of (R)-Strongylodiols C and D.
abstract: The first total syntheses of two marine natural products, (R)-strongylodiols C and D, with 99% ee were achieved. The key steps of the strategy include the zipper reaction of an alkyne, the asymmetric alkynylation of an unsaturated aliphatic aldehyde catalyzed with Trost's ProPhenol ligand, and the Cadiot-Chodkiewicz cross-coupling reaction of a chiral propargylic alcohol with a bromoalkyne.
authors.affiliation: Department of Applied Chemistry, China Agricultural University , 2 West Yuanmingyuan Road, Beijing 100193, People's Republic of China.
authors.forename: Feipeng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Applied Chemistry, China Agricultural University , 2 West Yuanmingyuan Road, Beijing 100193, People's Republic of China.
authors.forename: Jiangchun
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Department of Applied Chemistry, China Agricultural University , 2 West Yuanmingyuan Road, Beijing 100193, People's Republic of China.
authors.forename: Shuoning
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Applied Chemistry, China Agricultural University , 2 West Yuanmingyuan Road, Beijing 100193, People's Republic of China.
authors.forename: Minyan
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Applied Chemistry, China Agricultural University , 2 West Yuanmingyuan Road, Beijing 100193, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Applied Chemistry, China Agricultural University , 2 West Yuanmingyuan Road, Beijing 100193, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Applied Chemistry, China Agricultural University , 2 West Yuanmingyuan Road, Beijing 100193, People's Republic of China.
authors.forename: Jianyou
authors.initials: J
authors.lastname: Mao
authors.affiliation: Department of Applied Chemistry, China Agricultural University , 2 West Yuanmingyuan Road, Beijing 100193, People's Republic of China.
authors.forename: Shikuo
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Applied Chemistry, China Agricultural University , 2 West Yuanmingyuan Road, Beijing 100193, People's Republic of China.
authors.forename: Bing
authors.initials: B
authors.lastname: Zheng
authors.affiliation: Department of Applied Chemistry, China Agricultural University , 2 West Yuanmingyuan Road, Beijing 100193, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Applied Chemistry, China Agricultural University , 2 West Yuanmingyuan Road, Beijing 100193, People's Republic of China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Bian
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D008024:Ligands; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000480:Alkynes; D001688:Biological Products; D008024:Ligands; D020005:Propanols; C000608593:strongylodiol C; C000608594:strongylodiol D; C028255:propargyl alcohol