title: Initial Experience of Applying TWIST-Dixon With Flexible View Sharing in Breast DCE-MRI.
abstract: We developed a new fast imaging technique with flexible time-resolved angiography with stochastic trajectories (TWIST) view sharing to achieve variable temporal resolution and with flexible echo time Dixon to achieve robust fat suppression and to evaluate its application in breast dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI).
  
  
  
  The TWIST-Dixon technique was improved with more flexible view sharing and echo times (TWIST-Dixon-Flex). In a dynamic series, each measurement can be separately prescribed as "full," "partial," or "center-only." The spatial and temporal resolution can then be adjusted throughout the measurements to match the dynamic characteristics of contrast enhancement at different phases. The potential advantages of TWIST-Dixon-Flex were evaluated with 18 clinical breast DCE MRI cases. A mixed-effects analysis of variance (ANOVA) was performed to compare the image quality with that of the conventional images.
  
  
  
  The ANOVA showed that the quality of postcontrast TWIST-Dixon-Flex images was significantly higher than that of the conventional images. The TWIST-Dixon-Flex technique also provided the capability to detect differences in rapid contrast uptake from different regions of the breast tumor, which is not possible with conventional breast DCE-MRI.
  
  
  
  The new TWIST-Dixon-Flex technique provides potentially valuable information about early tumor enhancement, and maintains excellent image quality at peak and postcontrast enhancement. This technique could help overcome the compromise on spatial over temporal resolution in clinical breast imaging.
authors.affiliation: Department of Radiology and Imaging Science, Indiana University School of Medicine, Indianapolis, IN.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Le
authors.affiliation: Department of Radiology and Imaging Science, Indiana University School of Medicine, Indianapolis, IN.
authors.forename: Hal D
authors.initials: HD
authors.lastname: Kipfer
authors.affiliation: Siemens Healthcare, Erlangen, Germany.
authors.forename: Dominik M
authors.initials: DM
authors.lastname: Nickel
authors.affiliation: Siemens Healthcare, Erlangen, Germany.
authors.forename: Randall
authors.initials: R
authors.lastname: Kroeker
authors.affiliation: Siemens Healthcare, Erlangen, Germany.
authors.forename: Brian M
authors.initials: BM
authors.lastname: Dale
authors.affiliation: Department of Radiology and Imaging Science, Indiana University School of Medicine, Indianapolis, IN.
authors.forename: Stephanie P
authors.initials: SP
authors.lastname: Holz
authors.affiliation: Siemens Healthcare, Erlangen, Germany.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Weiland
authors.affiliation: Department of Radiology and Imaging Science, Indiana University School of Medicine, Indianapolis, IN. Electronic address: clin1@iupui.edu.
authors.forename: Chen
authors.initials: C
authors.lastname: Lin
mesh_terms: D000328:Adult; D000792:Angiography / Q000379:methods*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged
keywords: Accelerated acquisition; Breast cancer diagnosis; Dynamic contrast enhanced MRI; Improved fat suppression; Initial uptake slope; k-space view sharing