title: Diclocor is superior to diclofenac sodium and quercetin in normalizing biochemical parameters in rats with collagen-induced osteoarthritis.
abstract: OBJECTIVE
  The aim of the present study was to investigate anti-inflammatory activity of Diclocor in the setting of collagen-induced osteoarthritis in rats in comparison with its active monocomponents-diclofenac sodium and quercetin.
  
  
  METHODS
  The study was conducted on the model of collagen-induced osteoarthritis and included measurement of sialic acids, glycoproteins, C-reactive protein, prostaglandin E2, 6-keto-prostaglandin F1α, thromboxane B2, and leukotriene B4. Lastly, morphologic study with morphometry was also performed.
  
  
  RESULTS
  Diclocor is superior to quercetin and diclofenac sodium by the degree of pharmacological effect on some of the studied parameters. The differences between the values were statistically significant.
  
  
  CONCLUSIONS
  Diclocor is a promising corrector of inflammatory and destructive joint diseases. Owing to the presence of both diclofenac sodium and quercetin in its composition, Diclocor exhibits a complex mechanism of anti-inflammatory action affecting cyclooxygenase and lipoxygenase ways of arachidonic acid biotransformation.
authors.affiliation: National University of Pharmacy, 27 Pushkinska Str., Kharkiv, 61057, Ukraine.
authors.forename: I A
authors.initials: IA
authors.lastname: Zupanets
authors.affiliation: National University of Pharmacy, 27 Pushkinska Str., Kharkiv, 61057, Ukraine.
authors.forename: S K
authors.initials: SK
authors.lastname: Shebeko
authors.affiliation: National University of Pharmacy, 27 Pushkinska Str., Kharkiv, 61057, Ukraine. oleksii.s.popov@gmail.com.
authors.forename: O S
authors.initials: OS
authors.lastname: Popov
authors.affiliation: PJSC SIC "Borshchahivskiy CPP", Kyiv, Ukraine.
authors.forename: A S
authors.initials: AS
authors.lastname: Shalamay
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D003094:Collagen / Q000633:toxicity; D004008:Diclofenac / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D004338:Drug Combinations; D005260:Female; D008297:Male; D010003:Osteoarthritis / Q000188:drug therapy* / Q000503:physiopathology; D011794:Quercetin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D004008:Diclofenac; D003094:Collagen; D011794:Quercetin
keywords: Biochemical parameters; Collagen-induced osteoarthritis; Diclocor; Diclofenac sodium; Quercetin