title: The Role of Prostaglandin E(2) in Tumor-Associated Immunosuppression.
abstract: Tumor-associated inflammation can create an immunosuppressive microenvironment allowing tumor cells to escape immunosurveillance. Inhibiting immunosuppression remains one of the major challenges in cancer immunotherapy via checkpoint inhibitors. Recent preclinical data from the Reis e Sousa group may provide a strong rationale for developing new therapeutics to subvert tumor-induced immunosuppression via prostaglandin inhibition.
authors.affiliation: Laboratory for Inflammation and Cancer, the Biodesign Institute at Arizona State University, Tempe, AZ 85287, USA.
authors.forename: Dingzhi
authors.initials: D
authors.lastname: Wang
authors.affiliation: Laboratory for Inflammation and Cancer, the Biodesign Institute at Arizona State University, Tempe, AZ 85287, USA; Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA; Department of Research and Division of Gastroenterology, Mayo Clinic, Scottsdale, AZ 85259, USA. Electronic address: duboisrn@asu.edu.
authors.forename: Raymond N
authors.initials: RN
authors.lastname: DuBois
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000276:immunology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D019139:Tumor Escape
chemical_list: D011451:Prostaglandin-Endoperoxide Synthases