title: Hepatoprotective triterpenes from the gum resin of Boswellia carterii.
abstract: Ten tirucallane-type triterpenes named boscartene A-J and a nor-tetracyclic triterpene boscartene K, together with ten known compounds were isolated from the gum resin of Boswellia carterii Birdw. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis. In vitro assay, some of these compounds (10 μM) showed moderate hepatoprotective activities against d-galactosamine-induced HL-7702 cell damage.
authors.affiliation: Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing 100053, People's Republic of China. Electronic address: wangyg84@126.com.
authors.forename: Yan-Gai
authors.initials: YG
authors.lastname: Wang
authors.affiliation: College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyan 473061, People's Republic of China. Electronic address: maqinge2006@163.com.
authors.forename: Qin-Ge
authors.initials: QG
authors.lastname: Ma
authors.affiliation: College of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, People's Republic of China. Electronic address: pstianjin@126.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Tian
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: renjin5@163.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Ren
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: wangaiguo@imm.ac.cn.
authors.forename: Ai-Guo
authors.initials: AG
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: jitf@imm.ac.cn.
authors.forename: Teng-Fei
authors.initials: TF
authors.lastname: Ji
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: yjb@imm.ac.cn.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: suyalun@imm.ac.cn.
authors.forename: Ya-Lun
authors.initials: YL
authors.lastname: Su
mesh_terms: D029743:Boswellia / Q000737:chemistry*; D002460:Cell Line; D019610:Cytoprotection; D005688:Galactosamine / Q000009:adverse effects; D022781:Hepatocytes / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D012116:Resins, Plant / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D012116:Resins, Plant; D014315:Triterpenes; C514393:tirucallane; D005688:Galactosamine
keywords: Boscartene A–K; Boswellia carterii; Hepatoprotective activities; Tirucallane-type triterpenes