title: Sugar- and artificially sweetened beverages and intrahepatic fat: A randomized controlled trial.
abstract: OBJECTIVE
  To test the hypothesis that substituting artificially sweetened beverages (ASB) for sugar-sweetened beverages (SSB) decreases intrahepatocellular lipid concentrations (IHCL) in overweight subjects with high SSB consumption.
  
  
  METHODS
  About 31 healthy subjects with BMI greater than 25 kg/m(2) and a daily consumption of at least 660 ml SSB were randomized to a 12-week intervention in which they replaced SSBs with ASBs. Their IHCL (magnetic resonance spectroscopy), visceral adipose tissue volume (VAT; magnetic resonance imaging), food intake (2-day food records), and fasting blood concentrations of metabolic markers were measured after a 4-week run-in period and after a 12-week period with ASB or control (CTRL).
  
  
  RESULTS
  About 27 subjects completed the study. IHCL was reduced to 74% of the initial values with ASB (N = 14; P < 0.05) but did not change with CTRL. The decrease in IHCL attained with ASB was more important in subjects with IHCL greater than 60 mmol/l than in subjects with low IHCL. ALT decreased significantly with SSB only in subjects with IHCL greater than 60 mmol/l. There was otherwise no significant effect of ASB on body weight, VAT, or metabolic markers.
  
  
  CONCLUSIONS
  In subjects with overweight or obesity and a high SSB intake, replacing SSB with ASB decreased intrahepatic fat over a 12-week period.
authors.affiliation: Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Campos
authors.affiliation: Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
authors.forename: Camille
authors.initials: C
authors.lastname: Despland
authors.affiliation: Department of Clinical Research, University of Bern and Institute of Diagnostic Interventional and Pediatric Radiology, University Hospital, Bern, Switzerland.|Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
authors.forename: Vaclav
authors.initials: V
authors.lastname: Brandejsky
authors.affiliation: Department of Clinical Research, University of Bern and Institute of Diagnostic Interventional and Pediatric Radiology, University Hospital, Bern, Switzerland.
authors.forename: Roland
authors.initials: R
authors.lastname: Kreis
authors.affiliation: Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
authors.forename: Philippe
authors.initials: P
authors.lastname: Schneiter
authors.affiliation: Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital (CHUV), Lausanne, Switzerland.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Chiolero
authors.affiliation: Department of Clinical Research, University of Bern and Institute of Diagnostic Interventional and Pediatric Radiology, University Hospital, Bern, Switzerland.
authors.forename: Chris
authors.initials: C
authors.lastname: Boesch
authors.affiliation: Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
authors.forename: Luc
authors.initials: L
authors.lastname: Tappy
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000328:Adult; D001628:Beverages / Q000009:adverse effects; D001835:Body Weight / Q000187:drug effects; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000187:drug effects* / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000178:diet therapy / Q000378:metabolism; D050177:Overweight / Q000178:diet therapy / Q000378:metabolism; D013549:Sweetening Agents / Q000494:pharmacology*
chemical_list: D004040:Dietary Carbohydrates; D013549:Sweetening Agents