title: An Evaluation of Systemic Vancomycin Dosing in Obese Patients.
abstract: We retrospectively identified 67 patients with severe or morbid obesity (body mass index ≥35 kg/m(2)) who had received intravenous vancomycin at our institution. We observed that an initial dose of 45 to 65 mg/kg vancomycin per day based upon ideal body weight rather than actual body weight was more predictive of initial trough concentrations between 15 and 20 mcg/mL.
authors.affiliation: Brigham and Women's Hospital , Boston, Massachusetts.
authors.forename: David W
authors.initials: DW
authors.lastname: Kubiak
authors.affiliation: Brigham and Women's Hospital , Boston, Massachusetts.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Alquwaizani
authors.affiliation: Brigham and Women's Hospital , Boston, Massachusetts.
authors.forename: David
authors.initials: D
authors.lastname: Sansonetti
authors.affiliation: Brigham and Women's Hospital , Boston, Massachusetts.
authors.forename: Megan E
authors.initials: ME
authors.lastname: Barra
authors.affiliation: Brigham and Women's Hospital , Boston, Massachusetts.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Calderwood
keywords: obese; pharmacokinetics; vancomycin